Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Relating to the size of solids.
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
Separation of molecules and particles by a simultaneous action of carrier liquid flow and focusing field forces (electrical, sedimentation, or thermal), without a stationary phase.
Nanometer-sized, hollow, spherically-shaped objects that can be utilized to encapsulate small amounts of pharmaceuticals, enzymes, or other catalysts (Glossary of Biotechnology and Nanobiotechnology, 4th ed).
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.
The branch of medicine concerned with the application of NANOTECHNOLOGY to the prevention and treatment of disease. It involves the monitoring, repair, construction, and control of human biological systems at the molecular level, using engineered nanodevices and NANOSTRUCTURES. (From Freitas Jr., Nanomedicine, vol 1, 1999).
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Tree-like, highly branched, polymeric compounds. They grow three-dimensionally by the addition of shells of branched molecules to a central core. The overall globular shape and presence of cavities gives potential as drug carriers and CONTRAST AGENTS.
A cellulose of varied carboxyl content retaining the fibrous structure. It is commonly used as a local hemostatic and as a matrix for normal blood coagulation.
A polyester used for absorbable sutures & surgical mesh, especially in ophthalmic surgery. 2-Hydroxy-propanoic acid polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with 1,4-dioxane-2,5-dione copolymer of molecular weight about 80,000 daltons.
A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Hard or soft soluble containers used for the oral administration of medicine.
Transport proteins that carry specific substances in the blood or across cell membranes.
Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
A group of inosine ribonucleotides in which the phosphate residues of each inosine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
Method of using a polycrystalline powder and Rietveld refinement (LEAST SQUARES ANALYSIS) of X-RAY DIFFRACTION or NEUTRON DIFFRACTION. It circumvents the difficulties of producing single large crystals.
Consists of a polypeptide chain and 4'-phosphopantetheine linked to a serine residue by a phosphodiester bond. Acyl groups are bound as thiol esters to the pantothenyl group. Acyl carrier protein is involved in every step of fatty acid synthesis by the cytoplasmic system.
Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.
A biocompatible polymer used as a surgical suture material.
Identification of genetic carriers for a given trait.
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
Characteristics or attributes of the outer boundaries of objects, including molecules.
Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
An individual having different alleles at one or more loci regarding a specific character.
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
A ubiquitously expressed folic acid transporter that functions via an antiporter mechanism which is coupled to the transport of organic phosphates.
The chemical and physical integrity of a pharmaceutical product.
Small encapsulated gas bubbles (diameters of micrometers) that can be used as CONTRAST MEDIA, and in other diagnostic and therapeutic applications. Upon exposure to sufficiently intense ultrasound, microbubbles will cavitate, rupture, disappear, release gas content. Such characteristics of the microbubbles can be used to enhance diagnostic tests, dissolve blood clots, and deliver drugs or genes for therapy.
Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.
A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
A cell line derived from cultured tumor cells.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
The application of suitable drug dosage forms to the skin for either local or systemic effects.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
The rate dynamics in chemical or physical systems.
Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.
Injections made into a vein for therapeutic or experimental purposes.
The giving of drugs, chemicals, or other substances by mouth.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)
The relationship between the dose of an administered drug and the response of the organism to the drug.
Elements of limited time intervals, contributing to particular results or situations.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.

U.S. Food and Drug Administration approval of AmBisome (liposomal amphotericin B) for treatment of visceral leishmaniasis. (1/3649)

In August 1997, AmBisome (liposomal amphotericin B, Nexstar, San Dimas, CA) was the first drug approved for the treatment of visceral leishmaniasis by the U.S. Food and Drug Administration. The growing recognition of emerging and reemerging infections warrants that safe and effective agents to treat such infections be readily available in the United States. The following discussion of the data submitted in support of the New Drug Application for AmBisome for the treatment of visceral leishmaniasis shows the breadth of data from clinical trials that can be appropriate to support approval for drugs to treat tropical diseases.  (+info)

Systemic candidiasis with candida vasculitis due to Candida kruzei in a patient with acute myeloid leukaemia. (2/3649)

Candida kruzei-related systemic infections are increasing in frequency, particularly in patients receiving prophylaxis with antifungal triazoles. A Caucasian male with newly diagnosed acute myeloid leukaemia (AML M1) developed severe and persistent fever associated with a micropustular eruption scattered over the trunk and limbs during induction chemotherapy. Blood cultures grew Candida kruzei, and biopsies of the skin lesions revealed a candida vasculitis. He responded to high doses of liposomal amphotericin B and was discharged well from hospital.  (+info)

In vitro and in vivo activities of NS-718, a new lipid nanosphere incorporating amphotericin B, against Aspergillus fumigatus. (3/3649)

We evaluated the in vitro and in vivo potencies of a new lipid nanosphere that incorporates amphotericin B (AmB), NS-718, against Aspergillus fumigatus. The in vitro activity of NS-718 (the MIC at which 90% of strains are inhibited [MIC90], 0.25 microgram/ml) against 18 isolates of A. fumigatus was similar to that of deoxycholate AmB (D-AmB; Fungizone; MIC90, 0.25 microgram/ml), but NS-718 was more potent than liposomal AmB (L-AmB; AmBi-some; MIC90, 1.0 microgram/ml). The in vivo efficacy of NS-718 in a rat model of invasive pulmonary aspergillosis was compared with those of D-AmB and L-AmB. A low dose (1 mg/kg of body weight) of L-AmB was ineffective (survival rate, 0%), although equivalent doses of D-AmB and NS-718 were more effective (survival rate, 17%). However, a higher dose of NS-718 (3 mg/kg) was more effective (survival rate, 100%) than equivalent doses of D-AmB and L-AmB (survival rate, 0%). To explain these differences, pharmacokinetic studies showed higher concentrations of AmB in the plasma of rats treated with NS-718 than in the plasma of those treated with D-AmB. Our results suggest that NS-718, a new preparation of AmB, is a promising antifungal agent with activity against pulmonary aspergillosis.  (+info)

Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey. (4/3649)

Liposomal aminoglycosides have been shown to have activity against intracellular infections, such as those caused by Mycobacterium avium. Amikacin in small, low-clearance liposomes (MiKasome) also has curative and prophylactic efficacies against Pseudomonas aeruginosa and Klebsiella pneumoniae. To develop appropriate dosing regimens for low-clearance liposomal amikacin, we studied the pharmacokinetics of liposomal amikacin in plasma, the level of exposure of plasma to free amikacin, and urinary excretion of amikacin after the administration of single-dose (20 mg/kg of body weight) and repeated-dose (20 mg/kg eight times at 48-h intervals) regimens in rhesus monkeys. The clearance of liposomal amikacin (single-dose regimen, 0.023 +/- 0.003 ml min-1 kg-1; repeated-dose regimen, 0.014 +/- 0.001 ml min-1 kg-1) was over 100-fold lower than the creatinine clearance (an estimate of conventional amikacin clearance). Half-lives in plasma were longer than those reported for other amikacin formulations and declined during the elimination phase following administration of the last dose (from 81.7 +/- 27 to 30.5 +/- 5 h). Peak and trough (48 h) levels after repeated dosing reached 728 +/- 72 and 418 +/- 60 micrograms/ml, respectively. The levels in plasma remained > 180 micrograms/ml for 6 days after the administration of the last dose. The free amikacin concentration in plasma never exceeded 17.4 +/- 1 micrograms/ml and fell rapidly (half-life, 1.47 to 1.85 h) after the administration of each dose of liposomal amikacin. This and the low volume of distribution (45 ml/kg) indicate that the amikacin in plasma largely remained sequestered in long-circulating liposomes. Less than half the amikacin was recovered in the urine, suggesting that the level of renal exposure to filtered free amikacin was reduced, possibly as a result of intracellular uptake or the metabolism of liposomal amikacin. Thus, low-clearance liposomal amikacin could be administered at prolonged (2- to 7-day) intervals to achieve high levels of exposure to liposomal amikacin with minimal exposure to free amikacin.  (+info)

Lactic acid polymers as biodegradable carriers of fluoroquinolones: an in vitro study. (5/3649)

A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described. Duration and peak of release were found to depend on the molecular weight of the polymer. Its characteristics make it promising for treating chronic bone infections.  (+info)

Incorporation rates, stabilities, cytotoxicities and release of liposomal tetracycline and doxycycline in human serum. (6/3649)

Tetracycline and doxycycline were encapsulated in cationic, anionic and neutral liposomes. The amounts of antibiotic encapsulated, the stability of each preparation at 4 degrees C for 4 weeks, and the kinetics of the release of entrapped drug into human sera were assessed by high-performance liquid chromatography. The toxicities of the liposome preparations on human erythrocytes and HeLa 229 cells were evaluated in vitro. The results showed that doxycycline was entrapped more efficiently than tetracycline, and that doxycycline-entrapped liposomes were more stable at 4 degrees C and in human sera, and less cytotoxic than tetracycline-entrapped liposomes.  (+info)

Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group. (7/3649)

BACKGROUND: In patients with persistent fever and neutropenia, amphotericin B is administered empirically for the early treatment and prevention of clinically occult invasive fungal infections. However, breakthrough fungal infections can develop despite treatment, and amphotericin B has substantial toxicity. METHODS: We conducted a randomized, double-blind, multicenter trial comparing liposomal amphotericin B with conventional amphotericin B as empirical antifungal therapy. RESULTS: The mean duration of therapy was 10.8 days for liposomal amphotericin B (343 patients) and 10.3 days for conventional amphotericin B (344 patients). The composite rates of successful treatment were similar (50 percent for liposomal amphotericin B and 49 percent for conventional amphotericin B) and were independent of the use of antifungal prophylaxis or colony-stimulating factors. The outcomes were similar with liposomal amphotericin B and conventional amphotericin B with respect to survival (93 percent and 90 percent, respectively), resolution of fever (58 percent and 58 percent), and discontinuation of the study drug because of toxic effects or lack of efficacy (14 percent and 19 percent). There were fewer proved breakthrough fungal infections among patients treated with liposomal amphotericin B (11 patients [3.2 percent]) than among those treated with conventional amphotericin B (27 patients [7.8 percent], P=0.009). With the liposomal preparation significantly fewer patients had infusion-related fever (17 percent vs. 44 percent), chills or rigors (18 percent vs. 54 percent), and other reactions, including hypotension, hypertension, and hypoxia. Nephrotoxic effects (defined by a serum creatinine level two times the upper limit of normal) were significantly less frequent among patients treated with liposomal amphotericin B (19 percent) than among those treated with conventional amphotericin B (34 percent, P<0.001). CONCLUSIONS: Liposomal amphotericin B is as effective as conventional amphotericin B for empirical antifungal therapy in patients with fever and neutropenia, and it is associated with fewer breakthrough fungal infections, less infusion-related toxicity, and less nephrotoxicity.  (+info)

Liposomes fuse with sperm cells and induce activation by delivery of impermeant agents. (8/3649)

Sperm cell activation is a critical step in fertilization. To directly investigate the cell signaling events leading to sperm activation it is necessary to deliver membrane impermeant agents into the cytoplasm. In this study, the use of liposomes as possible agent-loading vectors was examined using (1) the octadecylrhodamine B (R18) and NBD phosphatidylethanolamine (NBD DHPE)/rhodamine phosphatidylethanolamine (rhod DHPE) fusion assays in bulk samples, (2) membrane transfer of fluorescence from liposome membranes labeled with R18 and rhodamine-tagged phosphatidylethanolamine (TRITC DHPE), and (3) lumenal transfer of impermeant calcium ions from liposomes to sperm cells, a process that stimulated sperm cell activation. Intermediate-sized unilamellar liposomes (98.17+/-15.34 nm) were prepared by the detergent-removal technique using sodium cholate as the detergent and a phosphatidylcholine/phosphatidylethanolamine/cholesterol (2:1:1 mole ratio) lipid composition. In the R18 fusion assays, self-quenching increased logarithmically with increasing concentrations of R18 in the liposome membranes; addition of unlabeled sperm to R18-labeled liposomes lead to a rapid release of self-quenching. In the NBD DHPE/rhod DHPE resonance energy transfer (RET) fusion assay, RET was rapidly reduced under similar conditions. In addition, individual sperm became fluorescent when TRITC DHPE-labeled liposomes were incubated with unlabeled sperm cells. Incubation of sperm cells with empty liposomes did not significantly affect sperm cell activation and did not alter cell morphology. However, incubation with Ca (10 mM)-loaded liposomes resulted in a time-dependent increase in sperm cell activation (7.5-fold over controls after 15 min). We conclude that liposomes can be used for direct loading of membrane-impermeant agents into sea squirt sperm cell cytoplasm, and that delivery occurs via fusion and content intermixing.  (+info)

In order to improve drug entrapment efficiency and loading capacity, nanostructured lipid carriers consisting of solid lipid and liquid lipid as a new type of colloidal drug delivery system were prepared. The dispersions of oridonin-loaded solid lipid nanoparticles and nanostructured lipid carriers were successfully prepared by the emulsion-evaporation and low temperature-solidification technique using monostearin as the solid lipid, caprylic/capric triglycerides as the liquid lipid and oridonin as the model drug. Their physicochemical properties of oridonin-loaded nanostructured lipid carriers and release behaviours were investigated and compared with those of solid lipid nanoparticles. As a result, the mean particle size was similar to 200 nm with narrow polydispersity index lower than 0.4 for all developed formulations. Zeta potential values were in the range -35 mV similar to -50 mV, providing good physical stability of all formulations. The differential scanning calorimetry and X-ray ...
Nanostructured lipid carriers (NLC) are stable colloidal formulations with notable advantages for drug delivery systems. Thanks to their physicochemical stability, biocompatibility, biodegradability and controlled drug release, they have received increasing attention for the last several years. The aim of the study was to prepare and characterize nanostructured lipid carriers (NLC). Both, the effect of the process parameters and the effect of the preemulsion composition on the NLC properties were investigated. In the work, different type of surfactants (i.e. decyl glucoside, Poloxamer188, Tween 80, sodium cholate) and their combinations were used to stabilize NLC dispersions. Moreover, several kinds of solid lipids (modified beeswax, gliceryl behenate, cetyl palmitate and berry wax) and liquid lipids (caprilic/capric triglyceride and decyl oleate) were applied. An ultrasonication method using a probe type sonicator was used to obtain NLC, and the time and energy of the process were modified ...
The process for homogeneous distribution of a cellular suspension in a porous carrier material (3) for tissue engineering under using a molded body (1) with a chamber (2) having an opening for receiving the carrier material, comprises introducing the carrier material provided for colonization into the chamber. (contd)
Nanostructured lipid carriers (NLCs) are drug-delivery systems and they are made out of solid and fluid lipids as a core matrix. It was demonstrated that NLCs uncover a f..
Objective: Rizatriptan Benzoate is the 5H1 receptor agonist and used in treatment of migraine, cluster headache. The main objective is to develop ideal anti-migraine nasal mucoadhesive microparticles as local and systemic drug delivery system. Method: An attempt was made to formulate the nasal mucoadhesive microparticle of Rizatriptan Benzoate with excipients like mucoadhesive polymers i.e HPMC, ethyl cellulose etc., by using modified solvent evaporation method. And evaluated them for production yield, drug loading efficiency, surface morphology by SEM, drug content, particle size, In-vitro drug release studies. The release rates were studied using GRAPHPAD PRISM software. Result and discussion: The prepared microparticles of Rizatriptan Benzoateformulations were found to be satisfactory particle size i.e in the range of 36.96 to 53.28µm,mucoadhesion time of F5 found to be 370 min,drug content was found to be72.86 % to 81.80 % and drug release of the drug follow zero order kinetic model. Optimized
Page contains details about N-Arginine-N-octyl chitosan-coated nanostructured lipid carriers . It has composition images, properties, Characterization methods, synthesis, applications and reference articles :
Nanostructured lipid carriers (NLC) composed of solid and liquid lipids, and surfactants are potentially good colloidal drug carriers. Before NLC can be us
Pulmonary Drug Delivery Devices Market: Overview Read the full report: This report on pulmonary drug delivery devices
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Yet despite holding so much cargo, the fully loaded nanocarriers are less than the thickness of a sheet of flimsy notebook paper.. The silica shell keeps the nanocarriers watertight. In addition, they do not interfere with healthy tissue, as Zhangs team showed by injecting healthy mice with empty nanocarriers or nanocarriers loaded with drug cargo. Five days after injection, they checked vital organs in the mice for evidence of toxicity and found none. This would indicate that the nanocarriers themselves do not trigger an adverse reaction in the body, and that the loaded nanocarriers are keeping their toxic cargo shielded from the body, said Zhang.. The UW team also designed the nanocarriers to be easily disassembled once they reached a desired location. Gentle heating from low-level infrared light was sufficient to make the nanocarriers break apart and disgorge their cargo, which is something doctors could apply to the tumor site during treatment.. As their final test of the nanocarrier ...
Development of newer drug carrier systems by the researchers has resulted in numerous breakthroughs in the development and manufacturing of ocular products. The ocular bioavailability of drugs at the posterior segment of the eye is a challenging task in the present scenario. Naturally derived macromolecular carriers are widely used to increase the efficacy of ocular drugs. They provide enhanced corneal permeability and retention effect at the surface of cornea for a prolonged period of time. In this regimen the present review focuses towards the major ocular diseases and their prevalence and development of efficient drug carrier systems utilizing various naturally derived macromolecules for improved delivery of drugs to treat ocular diseases ...
Organic light emitting devices are comprised of an organic charge carrier layer formed from a charge carrier material that is capable of forming a stable glass due to the presence of a compound having
Recent Advances reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer,
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The officers of RCSS/SSA had captured a lot of Yaba, heroin, and tools of drugs with drug carriers included an abbot on a car that went from Kholum to Kunhing.
One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.
The major challenges for the current shock and kill approach to HIV cure include insufficient potency of single LRAs, low LRA concentration in the lymphatic tissues that harbor most latent reservoirs, and toxicity. Nanocarriers have shown great promise in delivering combination therapeutics to specific sites or cells and therefore could address these challenges. However, nanocarriers have not been tested in a rigorous fashion as a strategy to deliver LRAs for HIV cure. In a few reported studies, LRAs were evaluated in vitro (24, 26, 27) or in vivo through systemic administration without specific targeting (25). In addition, no studies have investigated the delivery of combination LRAs, which may be necessary to sufficiently stimulate HIV reactivation (13). In this study, we focused on using targeted nanocarriers to deliver mechanistically distinct LRAs in combination and to specifically act on CD4+ T cells in the LNs.. Our approach shows many advantages over conventional drug delivery systems ...
Of fundamental importance in the design of a therapeutic drug carrier system is a thorough understanding of the factors which control its fate in the living animal. The use of liposomes as a carrier system able to improve the therapeutic efficacy of a wide range of drugs, requires manipulation of it …
Formulation strategies of nano lipid carrier for effective brain targeting of anti-AD drugs. Curr Pharm Des. 2020 Feb 12;: Authors: Alexander A, Agrawal M, Saraf S, Saraf S, Ajazuddin, Chougule MB Abstract NLC is a next-generation lipid nanocarrier which holds many advantages over other colloidal lipid carrier system like higher drug loading, better and controlled release and...
Silica and Dysprosia Aerogels as Drug Carriers for Indomethacin and Paracetamol, Abstracts of Papers of the American Chemical Society, American Chemical Society (ACS), Aug 2011.. ...
The 2018 Gordon Research Conference on Drug Carriers in Medicine and Biology will be held in Waterville Valley, NH. Apply today to reserve your spot.
Page contains details about gemcitabine/doxorubicin-loaded PEG1900-S-S-PLA5800 polymersomes . It has composition images, properties, Characterization methods, synthesis, applications and reference articles :
Cambridge, MA-based Alnylam Pharmaceuticals (NASDAQ:]) has been working with Tekmira Pharmaceuticals (TSE:]) of Vancouver, BC, since at least 2006 on
The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the
Principal Investigator:ISHIDA Tatsuhiro, Project Period (FY):2012-04-01 - 2015-03-31, Research Category:Grant-in-Aid for Scientific Research (B), Section:一般, Research Field:Physical pharmacy
The physiological environment is a crucial factor in biomedical systems, which can be regulated with relative ease both in vitro and in vivo. Control of pH has emerged as a powerful strategy in cancer therapy because pH has a profound effect on the interaction of a polymeric-based drug delivery system with tumor ce
[122 Pages Report] Check for Discount on Global Solid Tumors Drugs Sales Market Report 2016 report by QYResearch Group. Notes: Sales, means the sales volume of Solid Tumors Drugs...
Drug nanocarriers are nano-objects that transport a diagnostic or therapeutic agent either on its surface, within this bulk structure or within an internal cavity.. ...
RENOLIT thermoplastic 3D films are ideal for the three-dimensional shaping and wrapping of furniture, design objects and shop fittings or wall or ceiling elements. RENOLIT 3D Thermolaminates can be shaped and cut to suit any carrier material and offer a wide range of surface and texture options. RENOLIT ALKOREN products offer a wide range of wood-effect, single-colour and patterned finishes. RENOLIT COVAREN boasts even more additional features. These films have deep embossing, a realistic feel and metallic effect. Selected décors can be produced using synchronous EIR (Embossed in Register) technology. The synchronous pore EIR method creates a natural wood finish in virtually any shade or colour tone. There is also a full range of single-colour options available in both high-gloss and metallic finishes.. ...
Strips or rolls of carrier material coated with single or double-sided adhesive flanked sometimes by removable liners. Tapes are used to attach or arrange materials to each other or in relation to each other.
Hi moms! I am looking for advice. I have a 9 week old baby who is about 10 pounds. I have the baby ktan which I bought after researching different carriers and thought it would be ideal. However, Im finding it to be super warm in there (I live in California) and also not that easy to get on and off....
To make a CDMA cell phone work with a different carrier the PRL file must be replaced. Generally there are 3 steps to this process. 1. Read or Know SPC: Thi
Description: Subject matter wherein the enzyme or microbial cell is bonded to the polymeric carrier through an intermediate compound which attaches to both the enzyme and the carrier ...
One way to find clinics for free drug screening is through Its also possible to visit a free or low-cost health care clinic and get screened for drugs....
Does anyone know of a website that I can get the specs to see what carrier systems are matched to achieve 12 seer. For instance with a 38YRA030 would I have to up size air handler to get 12 seers?
Does anyone know of a website that I can get the specs to see what carrier systems are matched to achieve 12 seer. For instance with a 38YRA030 would I have to up size air handler to get 12 seers?
Ketofin Free is a medicine available in a number of countries worldwide. A list of US medications equivalent to Ketofin Free is available on the website.
Plants are natures remedies and have been used by human beings on earth since ancient times for food and medicine. Today there are global movements towards finding of herbal medicaments in plants to bring them in market via a suitable drug delivery system for mankind. The basic thought behind it is treatment of each disease is hidden in nature. However, delivery of herbal drugs also requires modification with the purpose to achieve sustain release, to increase patient compliance etc. previously herbal drugs could not attract scientists towards the modifications of novel drug delivery systems due to processing, standardizing, extracting and identification difficulties. But now days with the advancement in the technology, novel drug delivery systems (NDDS) open the door towards the development of herbal novel drug delivery system. With use of advance techniques protection from toxicity, enhancement in stability, improved bioavailability of herbal formulations, protection from physical and ...
TY - JOUR. T1 - Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery. AU - Kakadia, Partibha. AU - Conway, Barbara. PY - 2014. Y1 - 2014. N2 - Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics. The ability to incorporate drugs into nanoparticles offers a new prototype in drug delivery thus realizing the dual goal of both controlled release and site-specific drug delivery. Drug delivery to the skin is widely used for local and systemic delivery and has potential to be improved by application of nanoparticulate formulations. If investigated appropriately, solid lipid nanoparticles may open new opportunities in therapy of complex diseases which is difficult to treat.. AB - Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. Due to their unique size dependent properties, lipid nanoparticles ...
TY - JOUR. T1 - Scalable manufacturing processes for solid lipid nanoparticles. AU - Anderluzzi, Giulia. AU - Lou Ramirez, Gustavo. AU - Su, Yang. AU - Perrie, Yvonne. PY - 2019/11/30. Y1 - 2019/11/30. N2 - Solid lipid nanoparticles offer a range of advantages as delivery systems, but they are limited by effective manufacturing processes. Within this study we outline a high-throughput and scalable manufacturing process for solid lipid nanoparticles. The solid lipid nanoparticles were formulated from a combination of Tristearin and 1,2-Distearoyl-phosphatidylethanolamine-methyl-polyethyleneglycol conjugate-2000 and manufactured using the M-110P Microfluidizer® processor (Microfluidics Inc, Westwood, Massachusetts, US). The manufacturing process was optimized in terms of the number of process cycles (1 to 5) and of process pressure change (20,000, 25,000 and 30,000 psi). The solid lipid nanoparticles were purified using tangential flow filtration, and they were characterized in terms of their ...
The latest market report published by Credence Research, Inc. Global Pulmonary Drug Delivery Devices Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025, the Pulmonary Drug Delivery Devices market was valued at USD 134.6 Bn in 2016, and is expected to reach USD 218.6 Bn by 2025, expanding at a CAGR of 5.4% from 2017 to 2025.. Browse the full report Pulmonary Drug Delivery Devices Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025 at Market Insights. Increasing demand for noninvasive drug administration for respiratory diseases through pulmonary route is expected to boost the market of such devices. According to market experts the efficiency of pulmonary drug delivery devices is high because lungs possess ability to provide large absorptive surface area (up to 100 m2 ) but extremely thin (0.1 µm - 0.2 µm) absorptive mucosal membrane and ample ...
Market experts suggest that, There is a continuous growth in the market of drug delivery systems and will continue to grow at an impressive rate in future also. The novel drug delivery technologies enable to formulate the novel drug delivery devices by incorporating the drug molecules into new delivery systems, thus providing numerous therapeutic and commercial advantages. It was observed that NDDS market was segmented on the basis of route of administration, type of carrier and geographical region. In route of administration segment, injectable drug delivery system was observed as the largest market in 2015 followed by oral drug delivery system. Injectable drug delivery system comprises of several benefits over other dosage forms in cases such as unconsciousness, nausea, in emergency clinical episodes. The injectable administration route is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. On the basis ...
The Center for Business Intelligence (CBI) Summit on Novel Drug Delivery Strategies will convene industry leaders in the drug delivery, business development, lifecycle management and the commercialization arena to discuss the growing drug delivery market. The conference will examine the effects of incorporating a novel drug delivery system into the product lifecycle in early stages of development by assessing markets prior to commercialization.. Novel drug delivery systems are brought to the market through strategic alliances between pharmaceutical, biotech and drug delivery companies. Licensing agreements are an integral part of that process and their complexity varies with the value of the technology and the stage of development it is introduced. On Day 1 of the conference, Foley & Lardner LLP Associate Michael Yamauchi will lead the session, Analyzing Licensing Agreement Strategies through Interactive Mock Case Study Discussions. This executive exchange facilitates open discussion on key ...
TY - GEN. T1 - Synthesis of multi-stimuli responsive drug carriers for selective multiple drug release to tumor microenvironments. AU - Kim, Hyeon Ung. AU - Choi, Dae Gun. AU - Lee, Hyun Jee. AU - Shim, Min Suk. AU - Bong, Ki Wan. N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF-2016R1A5A1010148, ERC).. PY - 2020. Y1 - 2020. N2 - Multi-stimuli responsive drug carriers have been actively researched for controlled drug release in complex tumor microenvironments. In addition to the stimuli responsive drug release, combinatorial chemotherapy is essential to increase therapeutic effects. However, previous studies have shown limitation in the synthesis of multi-compartmental drug carriers that can encapsulate multiple drugs and release each drug in a controlled manner. Here, we report multi-stimuli responsive drug carriers containing pH- and redox-sensitive multicompartments. The drug carriers were created by stop flow lithography that can be used to ...
In this thesis, the method development and investigation of different liposomal formulations to incorporate and retain Camptothecin (CPT) is described. CPT is a potent anticancer drug that has shown to be active against a broad spectrum of cancers. However, due to its challenging physicochemical properties, like poor water solubility, severe toxic effects to normal tissues and instability, its clinical development has been limited for nearly 40 years. A strategy to overcome CPTs challenging properties is to use liposome-based carrier system. By taking advantage of this carrier system, we may solubilise CPT in the phospholipid bilayer of liposomes, protect it from blood proteins and achieve a selective drug accumulation in tumor tissues or tumor-associated cells by enhanced permeability and retention effect (EPR). A good liposome formulation of clinical utility must fulfil two important criteria. The liposomal drug carrier must incorporate CPT in the liposomal bilayer in a relevant therapeutic ...
The global novel drug delivery systems (NDDS) in cancer therapy market size was valued at USD 4.31 billion in 2016 and is projected to grow at a CAGR of 22.9% during the forecast period. Worldwide increasing incidence of cancer, availability of research funding, increase in awareness about alternative methods for treatment, and favorable reimbursement scenarios in developed nations are some of the key drivers of this market.
Novel Drug Delivery Systems Market Was Valued At USD 165.4 Bn In 2015, And Is Expected To Reach USD 202.5 Bn By 2022, Expanding At A CAGR Of 2.7% From 2016 To 2022
The utility of functional lipids in enhancing the dissolution and bioavailability of poorly water-soluble actives is well known. The use of lipid-based drug delivery systems in pharmaceutical product development is increasing due to the versatility of functional lipid excipients and the compatibility of these excipients with liquid, semi-solid, and solid pharmaceutical dosage forms.
Title:Chitosan and its Derivatives as Chemical Drug Delivery Carriers. VOLUME: 22 ISSUE: 7. Author(s):Lei Xing, Lina Du, Cheng-Qiong Luo, Tian-Jiao Zhou, Yong Zhu, Jia-Hui Gong, Yiguang Jin* and Hu-Lin Jiang*. Affiliation:State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing ...
In Vitro-In Vivo Characterization of Oleuropein loaded Nanostructured Lipid Carriers in the Treatment of Streptococcus pneumoniae induced Meningitis
TY - JOUR. T1 - Influence of chitosan coating on the liposomal surface on physicochemical properties and the release profile of nanocarrier systems. AU - Bang, S. H.. AU - Hwang, I. C.. AU - Yu, Y. M.. AU - Kwon, H. R.. AU - Kim, D. H.. AU - Park, H. J.. N1 - Funding Information: This study was supported by a grant from the Ministry of Agriculture and Forestry project, Republic of Korea.. PY - 2011/11. Y1 - 2011/11. N2 - Chitosan-coated nanoliposomes containing etofenprox or alpha-cypermethrin prepared by ultrasonic homogenization maintained a size distribution in the nanometre range. Nanoliposomes were constructed using different types and concentrations of chitosan to regulate the mean size and surface charge. As the chitosan concentration (0.10.5%, w/v) and the degree of deacetylation increased, surface charge also increased. The encapsulation efficiency and release profile were measured by gas chromatography. Encapsulation efficiency decreased slightly as chitosan concentration increased ...
PCS and AFM analyses were carried out in order to characterize size and size distribution, surface properties, and shape of nanoparticles. The analyses showed that the produced nanoparticles have almost spherical shape, and they are formed with desirable surface morphology (they have very smooth surface). In addition, it was turned out that egg albumin nanoparticles had a mean size of less than 100 nm. The simple coacervation method was considered an appropriate method for the production of this type of nanoparticles. Therefore, egg albumin nanoparticles can be considered very good candidates to be used as drug and food nano-carriers ...
Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation. Filed
Research in novel drug delivery systems is being explored competitively in order to attain maximum therapeutic effect while minimizing the adverse effects. Despite several advancements in pharmaceutical formulations, one of the major challenges still persisting is sustained drug release. Microencapsulation enacts as an intelligent approach with a strong therapeutic impact and is in demand globally in medical technology due to its specific and attractive properties, including biocompatibility, stability, target specificity, uniform encapsulation, better compliance, and controlled and sustained release patterns that are responsible for diminishing the toxicity and dosage frequency. Microparticles are successful delivery systems that encapsulate both water-insoluble and sparingly water-soluble agents to elicit their efficacy with a great potential attributed to their unique properties: particle size, shape, structure, drug loading, entrapment efficiency, porosity, and release profile. Several ...
Glycol chitosan (GC) and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules), and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy.
Niosomes are non-ionic surfactant based liposomes. Niosomes, the novel drug delivery system are self assembled vesicles primarily of synthetic surfactant incorporated with cholesterol as an excipient. They are the vesicles formed by hydrating the cholesterol and non-ionic surfactant. The main aim of niosome includes use of drug in efficient manner which includes reduced dose, reduced side effect, reduced dosage frequency, greater patient compliance and maximum concentration at the site of action so, that under exposure to the entire body. It includes higher therapeutic efficiency and reduced side effect. Niosomes are thought to be the better candidates drug delivery system due to the various factor like cost, stability, etc. various types of drug delivery is possible using niosomes like targetting drug action, ophthalmic, topical, parenteral, etc. Drug delivery potential of niosomes can be enhanced by using novel concept like proniosomes, discomes and aspasomes. Niosomes serves better aid in ...
Background: Recently, applications of albumin nanoparticles as drug delivery carriers have increased. Most toxicology studies have shown that surface chemistry and size of nanoparticles play an important role in biocompatibility and toxicity. Objective: The effect of desolvating agents with different chemical properties on the size of synthesized HSA NPs was investigated. Materials and Methods: Acetone, ethanol, methanol, and acetonitrile were used to synthesize HSA NPs with controllable size by desolvation method. Scanning electron microscopy (SEM), dynamic light scattering (DLS), and circular dichroism (CD) were employed to characterize produced particles. Finally, the toxicity of HSA NPs synthesized under different conditions was evaluated on PC-12 cells. Results: The sizes of synthesized particles differed according to the different solvents used. The sizes were 275.3 nm, 155.3 nm, 100.11 nm, and 66.2 nm for acetonitrile, ethanol, acetone, and methanol, respectively. CD showed that larger NPs had
Targeted delivery of drug molecules to tumor tissue is one of the most interesting and challenging endeavors faced in pharmaceutical field, due to the critical and pharmacokinetically specific environment that exists in tumor. Over these years, cancer targeting treatment has been greatly improved by new tools and approaches based on nanotechnology. The review firstly introduces the specific physical and chemical properties of a serial of nanomaterials, such as nanoparticles, micelles, dendrimers, carbon nanotubes, quantum dots, and nanofibers. It then places great emphasis on their application in the field of cancer therapy when they are used as nanocarrier systems. Based on the current status, the paper further discusses the unsolved problems and makes a perspective for the future prospects of the nanocarrier systems.
Low molecular weight heparin-modified isoliquiritigenin-loaded solid lipid nanoparticle (LMWH-ISL-SLN) was developed for injective application. The morphological observation, particle diameter and zeta potential of LMWH-ISL-SLN were characterized using transmission electron microscopy (TEM) and a Malvern Zetasizer. Its entrapment efficiency (EE) and drug loading (DL) were determined by ultracentrifuge. The in vitro release experiments were performed by dialysis technique. The cytotoxic effects of LMWH-ISL-SLN on Hep-G2 cell lines were determined using an MTT assay. Pharmacokinetic and tissue distribution studies were conducted in kunming mice after intravenous administration of LMWH-ISL-SLN. The average drug entrapment efficiency for LMWH-ISL-SLN was (99.80 ± 3.27) %, drug loading was (18.68 ± 1.51) %, mean particle size was (217.53 ± 4.86) nm and zeta potential was (-18.24 ± 2.47) mV. The in vitro release experiments demonstrated isoliquiritigenin release from LMWH-ISL-SLN was in line with Weibull
0035] It will be understood that the haptens of the current invention may be attached to the antigenicity-conferring carrier material (accm) via a crosslinking group. The crosslinking group may be any conventional cross linking group conventionally used in this field. The crosslinking group is ideally a functionalised linking group joining the accm to the hapten. The term crosslinking group as used herein is any bifunctional molecule able to covalently join the hapten element to an immunogenicity conferring carrier material. A suitable crosslinking group to link with alternative carrier materials is maleimide, or a maleimide derivative, for example when BTG-maleimide is used to conjugate with the hapten via a cysteine residue. Other cross-linking groups which could also couple this group on the cysteine include haloacetyls and pyridyldisulfides. Either Lys residue, or the Glu residue (C-terminal) may alternatively be used to conjugate to a carrier material, optionally via a cross-linking ...
Results: Optimized NLCs loaded with TA were exhibited spherical shape with particle size 286.1 nm, polydispersity index 0.317, zeta potential-21.9 mV and entrapment efficiency 86.19% respectively. The result of differential scanning calorimetry (DSC) showed that drug was dispersed in NLCs in a crystalline state. In vitro release studies revealed that drug release of optimized batch was 8.34 % and 88.84% at 1h and 8h respectively. The release kinetics of the optimized NLCs best fitted the peppas-korsmeyer model. Furthermore, morphological investigations by SEM showed that optimized batch exhibit a spherical shape and a smooth surface. ...
Liposomes which substantially avoid uptake into the mononuclear phagocyte system (MPS), termed Stealth liposomes, have recently been formulated (Allen, T.M. and Chonn, A., (1987) FEBS Lett. 223, 42-46). The pharmacokinetics of stealth liposomes as a function of liposome dose and a comparison to conv …
Formation of hollow microspheres by emulsion-solventdiffusion & evaporation process.Vol. 28, Iss. 2, Gastro-Retentive Floating Drug Delivery Systems: A Critical Review. ...
Formation of hollow microspheres by emulsion-solventdiffusion & evaporation process.Vol. 28, Iss. 2, Gastro-Retentive Floating Drug Delivery Systems: A Critical Review. ...
Formation of hollow microspheres by emulsion-solventdiffusion & evaporation process.Vol. 28, Iss. 2, Gastro-Retentive Floating Drug Delivery Systems: A Critical Review. ...
Drug carriers[edit]. This section needs expansion. You can help by adding to it. (August 2008) ... Hot melt extrusion has been shown to molecularly disperse poorly soluble drugs in a polymer carrier increasing dissolution ... The anti-cancer drug Doxorubicin in liposome delivery system is formulated by extrusion, for example. Hot melt extrusion is ... also utilized in pharmaceutical solid oral dose processing to enable delivery of drugs with poor solubility and bioavailability ...
Cheng, Y.; Xu, Z; Ma, M.; Xu, T. (2007). "Dendrimers as drug carriers: Applications in different routes of drug administration ... "Dendrimers as Potential Drug Carriers. Part I. Solubilization of Non-Steroidal Anti-Inflammatory Drugs in the Presence of ... D'Emanuele, A; Attwood, D (2005). "Dendrimer-drug interactions". Advanced Drug Delivery Reviews. 57 (15): 2147-2162. doi: ... for each drug in different environments. The data indicated that the binding stoichiometry of the drug with the membrane was 1: ...
Ajima, K; Yudasaka M; Murakami T; Maigné A; Shiba K; Iijima S (2005). "Carbon Nanohorns as Anticancer Drug Carriers". Mol. ... 2008). "Single wall carbon nanohorn as a drug carrier for controlled release". Chem. Phys. Lett. 461 (4-6): 189-192. Bibcode: ... 2008). "Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy". Nanomedicine. 3 (4): 453- ... 2005). "Carbon Nanohorns as Anticancer Drug Carriers". Molecular Pharmaceutics. 2 (6): 475-480. doi:10.1021/mp0500566. PMID ...
This useful structure allows them to act as drug carriers in the body, as long as the compounds to be delivered have compatible ... Cyclodextrin nanosponges were not discovered to have potential in being drug carriers until work done by Trotta and colleagues ... Trotta, Francesco; Zanetti, Marco; Cavalli, Roberta (2012-11-29). "Cyclodextrin-based nanosponges as drug carriers". Beilstein ... Although nanosponges are one three-thousandth the size of red blood cells, they each can carry thousands of drug molecules. ...
... is almost insoluble ... Spernath, A.; Aserin, A. (2006). "Microemulsions as carriers for drugs and nutraceuticals". ... Chopra's Indigenous Drugs of India (2nd ed.). Academic Publishers. pp. 178-179. ISBN 978-81-85086-80-4. Ashurst, Philip R. ( ...
GRN 000046, gamma-cyclodextrin Uekama, Kaneto; Hirayama, Fumitoshi; Irie, Tetsumi (1998). "Cyclodextrin Drug Carrier Systems". ... Cyclodextrins were also shown to enhance mucosal penetration of drugs. β-cyclodextrins are used to produce stationary phase ... They are used in food, pharmaceutical, drug delivery, and chemical industries, as well as agriculture and environmental ... ISBN 978-3527306732.CS1 maint: uses authors parameter (link) Gu, Alice; Wheate, Nial (2021). "Macrocycles as drug-enhancing ...
"Puerto Rico Enlists Mail Carriers in Drug War". The Beaver County Times. June 23, 1993. Retrieved January 12, 2018. "DEA ... Though recreational drug use was uncommon in Puerto Rico in the 1950s, it had markedly increased in the 1960s. By the following ... 2005). Drugs and democracy in Latin America: The impact of U.S. policy. Lynne Rienner Publishers. pp. 324-328. ISBN ... A number of drug cartels discovered that Puerto Rico functioned as an efficient transfer point while trafficking contraband ...
Crit Rev Ther Drug Carrier Syst. 5 (1): 21-67. PMID 3293807.. ... Drug delivery is another application that utilizes BSM coatings ... The behavior of BSM and drugs is investigated to ensure that one element does not disrupt the function of the other. Coatings ... These compartments are composed of hydrophilic polymers that enable the release of a particular drug at a specified rate and ... Mucin interaction with the pharmaceutical product itself and other proteins encountered in the body is vital for the drug ...
Ulbrich K, Subr V (February 2010). "Structural and chemical aspects of HPMA copolymers as drug carriers". Adv. Drug Deliv. Rev ... The concept of using pHPMA as polymeric drug carriers has opened a new perspective in modern pharmaceutical science, and ... Thus, it is frequently used as macromolecular carrier for low molecular weight drugs (especially anti-cancer chemotherapeutic ... Drug Deliv. Rev. 62 (2): 122-49. doi:10.1016/j.addr.2009.10.004. PMC 2836498. PMID 19919846. Vasey PA, Kaye SB, Morrison R, ...
Critical Reviews in Therapeutic Drug Carrier Systems. 30 (1): 1-49. doi:10.1615/CritRevTherDrugCarrierSyst.2013005469. PMID ... "antiviral drug". Retrieved 2021-04-14. Dolgin, Elie (2021-04-14). "The race for antiviral drugs to beat ... Overall, the notion of virucide differs from an antiviral drug, such as Aciclovir, which inhibits the proliferation of the ... "Feasibility of a combined carrier test for disinfectants: studies with a mixture of five types of microorganisms". American ...
Khandare JJ, Minko T (2006). "Antibodies and peptides in cancer therapy". Critical Reviews in Therapeutic Drug Carrier Systems ... Technology Insight: cytotoxic drug immunoconjugates for cancer therapy. 2007 looks useful from the abstract. Targeted Therapy ... and to develop monoclonal antibody therapy as a targeted form of chemotherapy when they are often known as antibody-drug ...
Critical Reviews in Therapeutic Drug Carrier Systems. 17 (5): 47. doi:10.1615/CritRevTherDrugCarrierSyst.v17.i5.30. ISSN 0743- ... Hussain, Alamdar; Ahsan, Fakhrul (2005-03-21). "The vagina as a route for systemic drug delivery". Journal of Controlled ... Woolfson, A. David; Malcolm, R. Karl; Gallagher, Rory (2000-01-01). "Drug Delivery by the Intravaginal Route". ... "Why consider vaginal drug administration?". Fertility and Sterility. 82 (1): 1-12. doi:10.1016/j.fertnstert.2004.01.025. ISSN ...
Critical Reviews in Therapeutic Drug Carrier Systems. 21 (4): 257-317. doi:10.1615/CritRevTherDrugCarrierSyst.v21.i4.10. PMID ...
Impact of Therapeutic Carrier Systems and Gemcitabine's Drug Conjugates on Cancer Therapy". Critical Reviews in Therapeutic ... As of 2014, drug interactions had not been studied. Gemcitabine is a chemotherapy drug that works by killing any cells that are ... "Drug Formulary/Drugs/ gemcitabine - Provider Monograph". Cancer Care Ontario. Retrieved 6 December 2020. National Cancer ... Li Y, Li P, Li Y, Zhang R, Yu P, Ma Z, Kainov DE, de Man RA, Peppelenbosch MP, Pan Q (December 2020). "Drug screening ...
Critical Reviews in Therapeutic Drug Carrier Systems. 24 (6): 493-545. doi:10.1615/CritRevTherDrugCarrierSyst.v24.i6.10. PMID ... Risks for developing osteomyelitis include diabetes, intravenous drug use, prior removal of the spleen, and trauma to the area ... When adults are affected, it may be because of compromised host resistance due to debilitation, intravenous drug abuse, ... Local and sustained availability of drugs have proven to be more effective in achieving prophylactic and therapeutic outcomes. ...
... drug carriers are also able to target specific cells. This can be done by manufacturing a material to bond to ... Materials used in drug delivery in the past ten years have primarily been polymers. However, nanotechnology has opened the door ... Polymers also tend to swell in liquid which can cause an unwanted burst of drugs. The lack of swelling shown by most ceramics ... The large surface area to volume ratio of nanophase materials makes it possible for large amounts of drugs to be released over ...
These water-soluble can be applied into drug or gene carriers. There are two main advantages for polyrotaxanes applied to drug/ ... The drastic structural change can be used for programmed drug or gene delivery, in which the drug or gene can be released with ... The drastic structural change can be used for programmed drug or gene delivery, of which drug or gene can be released with the ... rotaxanes and capsulated drugs/genes and provides the carriers with other predetermined functions. As the network is further ...
Cevc, G (2004). "Lipid vesicles and other colloids as drug carriers on the skin". Advanced Drug Delivery Reviews. 56 (5): 675- ... In addition to gene and drug delivery applications, liposomes can be used as carriers for the delivery of dyes to textiles, ... The liposome can be used as a drug delivery vehicle for administration of nutrients and pharmaceutical drugs, such as lipid ... the drug will also be neutralized, allowing it to freely pass through a membrane. These liposomes work to deliver drug by ...
"Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers". Biopolymers. 88 (2): 115-21. doi: ... Tu RS, Tirrell M (September 2004). "Bottom-up design of biomimetic assemblies". Advanced Drug Delivery Reviews. 56 (11): 1537- ... and can be utilised to act as therapeutic agents to treat diseases by transporting drugs across membranes to specific sites. ... Self-Assembled Platform for Nanoscale Drug Delivery Applications". ACS Applied Bio Materials. 1 (6): 1830-41. doi:10.1021/ ...
Folkman J, Long DM (March 1964). "The use of silicone rubber as a carrier for prolonged drug therapy". The Journal of Surgical ... " Archived from the original on 1 January 2017. Retrieved 1 January 2017.. ... Drug interactions: Efavirenz appears to decrease etonogestrel levels[27] and increase rates of undesired pregnancy among ... Folkman and Long published the first study demonstrating that such a rod could be used to deliver drugs.[39] In 1966 Dziuk and ...
... in addition to carriers of anti-cancer drugs to diseased tissue and bone morphogenetic protein 2. She also demonstrated the ... Combining carrier erosion and hindered drug diffusion for predicting release kinetics". Acta Biomaterialia. 9 (9): 8346-8353. ... "Mechanism of erosion of nanostructured porous silicon drug carriers in neoplastic tissues". Nature Communications. 6 (1): 6208 ... Segal and her research team engineered porous silicon carriers containing nerve growth factor for delivery to the brain in ...
Gold nanoparticles are being investigated as carriers for drugs such as Paclitaxel. The administration of hydrophobic drugs ... Nanoparticle-mediated drug delivery is feasible only if the drug distribution is otherwise inadequate. These cases include drug ... Also, the drug release and particle disintegration can vary depending on the system (e.g. biodegradable polymers sensitive to ... Gratton SE, Pohlhaus PD, Lee J, Guo J, Cho MJ, Desimone JM (August 2007). "Nanofabricated particles for engineered drug ...
Therefore, drugs that are substrates of these carriers will have modified pharmacokinetics. Plasma concentration of sorafenib ... Retrieved 30 September 2018. "Sutent Approval History". Retrieved 30 September 2018.. ... In vitro protein binding is 99,5% for both drugs. The drugs are mainly metabolized in the liver by oxidative metabolism of ... Food and Drug Administration. Retrieved 20 September 2018. "CAPRELSA" (PDF). FDA. Food and Drug Administration. Retrieved 20 ...
"Cocaine carrier pigeons are the latest drug smuggling technique". British GQ. Retrieved 2017-05-25.. ... The German apothecary Julius Neubronner used carrier pigeons to deliver urgent medication.[28] In 1977 a similar carrier pigeon ... "Carrier pigeon" redirects here. For the breed of show pigeon, see English Carrier pigeon. ... "Carrier pigeons still serve; Even in modern war they do messenger duty". The New York Times. April 12, 1936. p. SM26.. ...
"Microemulsions as a surrogate carrier for dermal drug delivery". Drug Development and Industrial Pharmacy. 35 (5): 525-47. doi: ... News & Perspective Drugs & Diseases CME & Education Academy Consult, Drugs & Diseases > Pediatrics: General Medicine. ... Deepinder F, Braunstein GD (2012). "Drug-induced gynecomastia: an evidence-based review". Expert Opinion on Drug Safety. 11 (5 ... Burger A, Abraham DJ (20 February 2003). Burger's Medicinal Chemistry and Drug Discovery, Autocoids, Diagnostics, and Drugs ...
These hydrogel capsules can act as carrier vessels for confined drugs and act as microreactor reservoirs. For certain ... Drug Carriers, Sub‐compartmentalized Microreactors, Artificial Organelles". Small. 6 (20): 2201-2207. doi:10.1002/smll. ...
Therefore, a topical formulation based on specific drug carriers has been considered inevitable.[citation needed] Lpath Inc has ... MS Drug ONO-4641 Slows Brain Legions By 92% Xie, B.; Shen, J.; Dong, A.; Rashid, A.; Stoller, G.; Campochiaro, P. A. (2009). " ... ONO-4641 (a drug of Ono Pharmaceutical Co., Ltd.) is a sphingosine-1-phosphate (S1P) receptor agonist which keeps lymphocytes ... The drug fingolimod (FTY720), which agonizes the S1P receptor, prevents autoimmune lymphocytes from moving from the lymphoid ...
Lin (2009). "Periodic mesoporous silica and organosilica with controlled morphologies as carriers for drug release". ... Controlled drug release is another aspect in which PMOs have been shown promise. The hydrophobic nature of the PMO walls allow ... PMOs have potential applications as catalysts, adsorbents, trapping agents, drug delivery agents, stationary phases in ... "Novel wrinkled periodic mesoporous organosilica nanoparticles for hydrophobic anticancer drug delivery". Journal of Porous ...
... phylogenetic characterization of superfamilies of secondary carriers that include drug exporters". Membrane Transporters in ... The PPi carrier ANK is concerned with bone formation and remodeling. 2.A.66.6 - The Putative Exopolysaccharide Exporter (EPS-E ... These proteins are distantly related to MATE and PST family members and therefore are believed to be secondary carriers. The ... a cationic drug efflux pump in A. thaliana (i.e., AtDTX1 aka AT2G04040; TC# 2.A.66.1.8) and the functionally uncharacterized ...
De Smet, Peter A.G.M. (December 1997). "The Role of Plant-Derived Drugs and Herbal Medicines in Healthcare". Drugs. 54 (6): 801 ... insurance carriers, and hospital providers". American Journal of Health Promotion. 12 (2): 112-22. doi:10.4278/0890-1171-12.2. ... 2006). "Drug-related hepatotoxicity". New England Journal of Medicine. 354 (7): 731-39. doi:10.1056/NEJMra052270. PMID 16481640 ... The U.S. Food and Drug Administration (FDA), has issued online warnings for consumers about medication health fraud.[157] This ...
S. pneumoniae resides asymptomatically in healthy carriers typically colonizing the respiratory tract, sinuses, and nasal ... Koiuszko, S; Bialucha, A; Gospodarek, E (2007). "[The drug susceptibility of penicillin-resistant Streptococcus pneumoniae]". ... Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme enoyl-acyl carrier protein reductase, ( ... or drug-resistant Strepotococcus pneumomoniae (DRSP). Until the year 2000 out of 60,000 yearly cases 40% and out of the 30,000 ...
... drug occupancy at a purported site of action can be inferred indirectly by competition studies between unlabeled drug and ... because bombardment with a cyclotron to prepare the radioisotope destroys any organic carrier for it. Instead, the isotope must ... Pharmacokinetics: In pre-clinical trials, it is possible to radiolabel a new drug and inject it into animals. Such scans are ... The uptake of the drug, the tissues in which it concentrates, and its eventual elimination, can be monitored far more quickly ...
Carrier for flexible printed circuits.. *boPET film is often used as the diaphragm material in headphones, electrostatic ... To bridge control surface gaps on sailplanes (gliders), reducing profile drag. ScienceEdit. *Amateur and professional visual ...
"U.S. Food and Drug Administration (FDA).. *Ebola: What You Need to Know - Scientific American articles related to Ebola; note ... Fruit bats are believed to be the normal carrier in nature, able to spread the virus without being affected by it.[1] Other ... "U.S. Food and Drug Administration (FDA) (Press release). 14 October 2020. Retrieved 14 October 2020.. This article incorporates ... "U.S. Food and Drug Administration (FDA) (Press release). 20 December 2019. Retrieved 22 December 2019.. ...
Drugs-aspirin, fexofenadine, warfarin, clopidogrel, prasugrel, isotretinoin, desmopressin and others. *Envenomation by mambas, ... Murthy P, Nilssen EL, Rao S, McClymont LG (1999). "A randomised clinical trial of antiseptic nasal carrier cream and silver ... The drugs oxymetazoline or phenylephrine are widely available in over-the-counter nasal sprays for the treatment of allergic ...
JEL: L65 - Chemicals; Rubber; Drugs; Biotechnology. JEL: L66 - Food; Beverages; Cosmetics; Tobacco. JEL: L67 - Other Consumer ... JEL: L92 - Railroads and Other Surface Transportation: Autos, Buses, Trucks, and Water Carriers; Ports. JEL: L93 - Air ...
Drug resistance is increasingly more common and presents a serious problem in persons who are immunocompromised. Prophylactic ... The exact process by which Candida species switch from acting as normal oral commensals (saprophytic) state in the carrier to ... With more sensitive detection techniques, this figure is reported to rise to 90%. This candidal carrier state is not considered ... Oral candidiasis can be treated with topical anti-fungal drugs, such as nystatin, miconazole, Gentian violet or amphotericin B ...
Negatively charged carriers, such as the electrons (the charge carriers in metal wires and many other electronic circuit ... Is electrical brain stimulation used (like drugs) to produce pleasures in humans in other settings than scientific experiments? ... The net direction of flow of a particular type of charge carrier in a particular system at a particular moment is a well ... But there are also examples of flow of positive charge carriers (as has been mentioned by other editors here), and those cases ...
It has been used not only in the study of neuronal plasticity and information processing but also in drug and toxin effects on ... Some studies have suggested that these bursts represent information carriers, expression of memory, a means for the network to ...
"Infection and Drug Resistance. 8: 119-128. doi:10.2147/IDR.S66739. PMC 4440423. PMID 26028977.. ... The winter tick which has affected moose populations in the 21st century is not a carrier of Lyme.[281] ... A hexavalent (OspA) protein subunit-based vaccine candidate VLA15 was granted fast track designation by the U.S. Food and Drug ... disease-modifying antirheumatic drugs (DMARDs), or arthroscopic synovectomy.[30] Physical therapy is recommended for adults ...
The drug is relatively inexpensive, but the cost of the drug is still very high for many of those in West African states. Fluid ... Once the rat has become a carrier, it will excrete the virus throughout the rest of its lifetime through feces and urine ...
... an application of the model in the 1920s was to detect typhoid carriers in London, who were either arriving from zones with ... illegal drug addicts, people infected with HIV, etc.).[4] ... "Estimating the Number of People Who Inject Drugs in A Rural ...
... is a controlled drug for the purpose of the Misuse of Drugs Act 1977 and Schedule 1 of the Misuse of Drugs Regulations ... Carrier, Neil C. M. (2007). Kenyan Khat: The Social Life of a Stimulant. Leiden: BRILL. ISBN 978-90-04-15659-3.. ... Khat drug profile The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) ... "ADF - Alcohol & Drug Foundation. Retrieved 2017-10-03.. *^ "Import restrictions: Kava and Khat , Office of Drug Control". www. ...
Unlike most other Brahmic scripts, it does not have separate independent vowel characters, instead of using a vowel carrier ...
Example of drugs that contain such compounds include topotecan, SN-38 (topoisomerase I), doxorubicin, and mitoxantrone ( ... Carriers with shorter TATA box sequences may produce lower levels of PG2 serum. ... Pharmaceutical companies have been designing cancer therapy drugs to target DNA in traditional methods over the years, and have ... which may cause carriers to have a disease phenotype. ... the toxicity of these drugs have pushed scientists to explore ...
Also used in carrier-to-noise-density ratio (not to be confused with carrier-to-noise ratio, in dB).. dBov or dBO. dB(overload ... dB drag racing. *Decade (log scale). *Loudness. *One-third octave § Base 10 ... relative to carrier - in telecommunications, this indicates the relative levels of noise or sideband power, compared with the ... relative to carrier - in telecommunications, this indicates the relative levels of noise or sideband power, compared with the ...
Warfarin is an anticoagulant that was approved as a drug for human use in 1954 and is much safer to use near humans and other ... The original carrier for the plague-infected fleas thought to be responsible for the Black Death was the black rat, and it has ... "Systematic overview of warfarin and its drug and food interactions". Arch. Intern. Med. 165 (10): 1095-106. doi:10.1001/ ... is commonly endemic in only a few rodent species and is usually transmitted zoonotically by rat fleas-common carrier rodents ...
Fifteen American aircraft carriers had assembled at the Ulithi atoll, preparatory to making a series of raids against the home ... This had the added benefit of eliminating the weight and considerable drag of the large and bulky floats, which in turn ... On 17 August they would launch their six Seirans before daybreak on a kamikaze mission against the American carriers. The ... They were submarine aircraft carriers able to carry three Aichi M6A Seiran aircraft underwater to their destinations. They were ...
2003: Mile High, British television series features a group of flight attendants working for the fictitious low-cost carrier " ... repeatedly crawled into the smoked filled and burning cabin to drag a number of passengers to safety, and were subsequently ... Western Airlines (1928) and Pan American World Airways (Pan Am) (1929) were the first US carriers to employ stewards to serve ... It is not limited to the air carrier at which the attendant is employed (although some initial documents showed the airlines ...
His mother is often a carrier; i.e., she has one abnormal and one normal IDS gene, and she passes along the abnormal gene to ... also was approved in Korea by the Ministry of Food and Drug Safety. For more information of Idursulfase beta, which is sold ... In this second case, the mother is not a carrier and the risk of a spontaneous mutation occurring again in the future sibling ... underwent clinical trial in 2006 and was subsequently approved by the United States Food and Drug Administration as an enzyme ...
The weapon purchase permit as well as the weapon carrier permit are required for the purchase of such weapons. In 2009, the ... For those with asthma, taking other drugs, or subject to restraining techniques that restrict the breathing passages, there is ... individuals convicted of narcotic/drug addiction, individuals convicted of assault, and individuals convicted of misusing ...
GnRH agonists are pregnancy category X drugs. Side effects[edit]. Side effects of the GnRH agonists are signs and symptoms of ... These drugs can be both peptides and small-molecules. They are modeled after the hypothalamic neurohormone GnRH, which ... Gestational carrier. *In vitro maturation. *Intracytoplasmic sperm injection. *Oocyte selection. *Ovarian hyperstimulation ...
Staff (29 January 2013) FDA approves new orphan drug Kynamro to treat inherited cholesterol disorder U.S. Food and Drug ... one or several of whom was a carrier of the mutation. The Afrikaner, French Canadians, Lebanese Christians, and Finns have high ... Pollack, Andrew (29 January 2013) F.D.A. Approves Genetic Drug to Treat Rare Disease The New York Times, Retrieved 31 January ... Statins effectively lower cholesterol and LDL levels, although sometimes add-on therapy with other drugs is required, such as ...
... is brought into the mitochondria through carrier proteins, and the absence of these carriers prevents the drug from ... "Drugs@FDA: FDA Approved Drug Products". Archived from the original on 2014-08-13. Retrieved 2016-11-07. ... Drug interactions[edit]. The additional or sequential use of other nephrotoxic drugs like aminoglycosides, amphotericin B, ... "Pentamidine Use During Pregnancy ,". Archived from the original on 2016-11-09. Retrieved 2016-11-10.. ...
U.S. Food and Drug Administration. (1993). Everything Added to Food in the United States. Boca Raton, Florida: C.K. Smoley (c/o ... They also act as vitamin carriers. Food proteins[edit]. Main article: Protein (nutrient) ... by the United States Food and Drug Administration. ... a key factor in the creation of the United States Food and Drug ...
On 24 February 1966, American troops drag the body of a Viet Cong fighter behind their M113 Armored Personnel Carrier for ...
It occurs at 5 percent among Hungarians,[152] although the carriers might be of Romani origin.[153] Among non Roma-speaking ... or after administering drugs.[182][183] ...
Churchland is here referring to the effects of drugs and brain damage on reasoning, the emotions, and consciousness. But the ... Also Richard Carrier has written in response to this argument.. ,ref,{{cite web,title=Arguments against Dualism,url=http://spot ...
Presence of a unique immunoglobulin as a carrier of reaginic activity". Journal of Immunology. 97 (1): 75-85. PMID 4162440. ... Food and Drug Administration) կողմից ճանաչվել է 0.1kU/l սահմանաչափով քանակական որոշման մեթոդ։ ... "Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects". The Journal of ...
The ability of lipid carriers to enhance solubility, absorption and thereby the bioavailability of poorly soluble molecules by ... and nanostructured lipid carriers (NLC): Their benefits as colloidal drug carrier systems. Pharmazie 61:375-386Google Scholar ... and nanostructured lipid carriers (NLC): Their benefits as colloidal drug carrier systems. Pharmazie 61(5):375-386Google ... Lipid carriers Drug delivery Solid lipid nanoparticles Liposomes Phytosome Gene delivery Abbreviations. BCS. Biopharmaceutics ...
Disadvantages associated with using liposomes as drug carriers involve poor control over drug release. Drugs which have high ... and/or safety of drug administration. Drug carriers are primarily used to control the release of a drug into systemic ... A drug carrier is any substrate used in the process of drug delivery which serves to improve the selectivity, effectiveness, ... Different types of drug carrier utilize different methods of attachment, and some carriers can even implement a variety of ...
Microspheres are too large to act as drug carriers into cells or tissue on their own; however, the team believes the ... where they are testing new forms of drug carriers. (Date of Image: 2006) [Image 1 of 4 related images. See Image 2.]. More ... nanoparticles are considered a promising drug carrier. Their tiny size lets them slip through cracks between cells and ... If localized drug delivery is an important goal, then nanospheres will fail.. While these results are discouraging, Eniola- ...
Purchase Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs - 1st Edition. Print Book & E-Book. ISBN ... of both microsized and nanosized drug carriers and NSAIDs before discussing the formulation aspects of these drug carriers that ... Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs 1st Edition. Formulation Challenges and Potential ... Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits ...
... Xiaojiao Yu,1 Ian Trase,1 Muqing Ren,2 Kayla Duval,1 Xing Guo ... "Design of Nanoparticle-Based Carriers for Targeted Drug Delivery," Journal of Nanomaterials, vol. 2016, Article ID 1087250, 15 ...
The use of ULVs as drug carriers has been the subject of extensive investigation. The lack of stability of lecithin liposomes ... These proteoliposomes are stable and have usefulness as carriers of various compounds including drugs for in vivo ... compounds added to increase stability in vivo have limited the usefulness of liposomes as carriers for administration of drugs ... Accordingly, one object of the present invention is to provide more stable large proteoliposomes capable of carrying drugs. ...
Here, advances on polyester dendrimers as smart carriers for drug delivery applications have been surveyed. Both covalent and ... Compared to traditional polymeric drug vehicles, these biodegradable dendrimers show excellent advantages especially as drug ... smart carriers; drug delivery pathways; polymersomes polyester dendrimers; biocompatibility; drug delivery; smart carriers; ... Polyester Dendrimers: Smart Carriers for Drug Delivery. Jean-dAmour K. Twibanire 1,2,* and T. Bruce Grindley 1,* ...
Liposomes as injectable drug carriers have been extensively investigated due to their biocompatibility and effective drug ... Liposomes as drug carriers Liposomes as injectable drug carriers have been extensively investigated due to their ... biocompatibility and effective drug encapsulating property. However, liposomes that are administered through intravenous ...
Elan, Wyeth Study Finds Alzheimers Drug Works in ApoE4 Non-Carriers. Jul 02, 2008 ... Home » Elan, Wyeth Study Finds Alzheimers Drug Works in ApoE4 Non-Carriers ... for the investigational Alzheimers drug bapineuzumab that shows the drug may be beneficial in patients who are non-carriers of ...
E-mail a copy of Rubius Aims To Turn Red Blood Cells Into Engineered Drug Carriers to a friend. ...
15,000 in bribes to intercept and deliver packages of illegal drugs. ... Federal prosecutors say Gresham was a mail carrier based at a postal facility in Newark. From October 2014 through September ... 15,000 in bribes to intercept and deliver packages of illegal drugs. ... 2017, he accepted bribes from two people who were getting parcels containing illegal drugs through the mail. ...
Alnylam has filed patents on new carrier particles for RNAi drugs, listing Alnylam scientists as the inventors, according to ... While these drugs hold promise because of their ability to specifically target genes in ways other drugs cant, the new RNA ... Tekmira has a lot at stake in this case, given how much of its future revenue depends on income from its drug-delivery ... Tekmira, for example, provides the carrier particles (a.k.a lipid nanoparticles) that Alnylam uses for its key experimental ...
A letter carrier is headed to prison for five years after delivering drugs through the mail, U.S. Atty. Ed Stantons office ...
The journal serves researchers from academia and industry, and will publish articles ranging from basic biology of drug and ... Articles describing drug dosage forms will be considered. ... Journal of Drug Delivery is a peer-reviewed, Open Access ... Carbon Nanotubes: An Emerging Drug Carrier for Targeting Cancer Cells. Vaibhav Rastogi,1 Pragya Yadav,1 Shiv Sankar ... During recent years carbon nanotubes (CNTs) have been attracted by many researchers as a drug delivery carrier. CNTs are the ...
In this review, we summarize several organic and inorganic PS carriers that have been studied to enhance the efficacy of ... Drug Carrier for Photodynamic Cancer Therapy by Tilahun Ayane Debele 1, Sydney Peng 2 and Hsieh-Chih Tsai 1,* ... Debele, T.A.; Peng, S.; Tsai, H.-C. Drug Carrier for Photodynamic Cancer Therapy. Int. J. Mol. Sci. 2015, 16, 22094-22136. ... Debele TA, Peng S, Tsai H-C. Drug Carrier for Photodynamic Cancer Therapy. International Journal of Molecular Sciences. 2015; ...
Regulations concerning drug testing laboratories are found in 49 CFR Part 40 Subpart F, Subpart Q and Subpart R and Appendices ... Drug testing laboratories must be certified by the Department of Health and Human Services. These laboratories receive, analyze ... Drug Testing Laboratories. Drug testing laboratories must be certified by the Department of Health and Human Services. These ... Regulations concerning drug testing laboratories are found in 49 CFR Part 40 Subpart F, Subpart Q and Subpart R and Appendices ...
The 2018 Gordon Research Conference on Drug Carriers in Medicine and Biology will be held in West Dover, VT. Apply today to ... Drug Carriers for Oncology Targets and Oncology Micro-Environmental Factors Discussion Leader: Paula Hammond (Massachusetts ... This GRC will be held in conjunction with the "Drug Carriers in Medicine and Biology (GRS)" Gordon Research Seminar (GRS). ... The 2018 Gordon Conference on Drug Carriers in Medicine and Biology builds on a rich tradition encompassing chemical, ...
... loading protein drugs, gene drugs, and anticancer chemical drugs, and via various routes of administration including oral, ... Chitosan nanoparticles are good drug carriers because of their good biocompatibility and biodegradability, and can be readily ... As a new drug delivery system, they have attracted increasing attention for their wide applications in, for example, ... Recent advances of chitosan nanoparticles as drug carriers Jun Jie Wang1, Zhao Wu Zeng1,2, Ren Zhong Xiao1, Tian Xie1, Guang ...
The 2020 Gordon Research Conference on Drug Carriers in Medicine and Biology will be held in West Dover, VT. Apply today to ... Conference History Drug Carriers in Medicine and Biology (GRS) Contribute Financially to This Conference Conference Fees ... This GRC will be held in conjunction with the "Drug Carriers in Medicine and Biology (GRS)" Gordon Research Seminar (GRS). ...
pH-sensitive unimolecular polymeric micelles: synthesis of a novel drug carrier.. Jones MC1, Ranger M, Leroux JC. ... The pH rise was associated with an increase in the in vitro release rate of progesterone, which was used as hydrophobic drug ... Since, the polymers were designed as potential delivery systems for the oral administration of hydrophobic drugs, they were ...
... certified ESD drag chains and plastic cable carriers, designed to prevent static shock and ignitable discharges. ... ESD, or Electrocstatic discharge, is a key component in several igus® cable carriers.. ESD ...
When I was searching for rehab centers I didnt realize how bad Carrier Clinic Inpatient Rehab drug rehab was. Scam-O-rama ... carrier clinic inpatient rehab drug rehab, carrier clinic inpatient rehab drug review, carrier clinic inpatient review, contact ... Carrier Clinic Inpatient Rehab drug rehab review When I was searching for rehab centers I didnt realize how bad Carrier Clinic ... Carrier Clinic Inpatient Rehab drug rehab with a primary focus on Mental health services and drug rehab. Specializing in ...
Alcohol & Drugs (Motor Carriers). DOT adds four opioids to testing program 11/14/2017. National. ... ...
... there are more than 30 drug delivery systems. Todays due to lacking the target specificity, the present scenario about drug ... Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications: 10.4018/978-1-5225-1762-7.ch018: In this pharma ... Red blood cells have strong and targeted potential carrier capabilities for varieties of drugs. Drug-loaded carrier ... and spleen of the body and hence drugs also. Resealed erythrocytes method of drugs delivery is secure and effective for drugs ...
... there are more than 30 drug delivery systems. Todays due to lacking the target specificity, the present scenario about drug ... Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications: 10.4018/978-1-5225-0754-3.ch012: In this pharma ... Red blood cells have strong and targeted potential carrier capabilities for varieties of drugs. Drug-loaded carrier ... "Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications." In Recent Advances in Drug Delivery Technology, ed. ...
... more effective way to deliver drugs to the colon than conventional drug-carriers, according to chemists at the University of ... more effective way to deliver drugs to the colon than conventional drug-carriers, according to chemists at the University of ... Researchers have tried to circumvent this problem by inserting the drugs into carrier molecules that resist breakdown in the ... Drug delivery to the colon is an ongoing challenge to physicians. Many drugs are destroyed by stomach acids before theyve had ...
Let us begin by discussing the fundamentals of nanoparticles and understand why they are being developed as drug carriers. ... In this video the basic principles of targeted drug delivery will be described and a method to evaluate biodistribution using ... Now that we understand the basics of nanoparticle drug delivery, lets see a demonstration that uses high-resolution imaging to ... You should now know the basic principles of nanodrug carriers, how to detect nanocarriers in tissue samples using high- ...
Homopolymer vesicles with a gradient bilayer membrane as drug carriers Lang Fan,a Hang Lu,a Kaidian Zou,a Jing Chena and ... Homopolymer vesicles with a gradient bilayer membrane as drug carriers L. Fan, H. Lu, K. Zou, J. Chen and J. Du, Chem. Commun. ... exhibiting thermo-responsive zeta potential and dispersibility and showing potential applications for anti-cancer drug delivery ...
... a finding that could change the way these nanomaterials are made and how they target their drug release. ... A new study from American and Israeli researchers has shown that nanostructures used to deliver cancer drugs act differently ... Diagram showing the degradation of silicon drug carriers over time--Courtesy of ATS. ... when the silicon carrier breaks down, the drugs are free to act upon the tumor. ...
  • This chapter will explain the different method of drug loading for resealed erythrocytes, their characterization, and applications in various therapies and associated health benefits. (
  • This study illustrates the development and characterization of metal‐drug coordination NPs with high drug content and variable external functionalizations. (
  • 9. Kataoka K, Haraha A, Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. (
  • DIGITAL.CSIC: Fluorescence characterization of drugs carriers systems formed by drug-silver nanoparticles complexes loaded on nanostructured PBS polymer. (
  • Fluorescence characterization of drugs carriers systems formed by drug-silver nanoparticles complexes loaded on nanostructured PBS polymer. (
  • Publications] T.Ooya,K.Arizono,N.Yui: 'Synthesis and characterization of an oligopeptide-terminated polyrotaxane as a drug carrier'Polym.Adv.Tech.. 11(8-12). (
  • FTIR and XPS characterization of the PSI materials after carrier-added F-18/F-19-radiolabeling reveals that depending on the material the F-18-labeling is likely to be accomplished either by substitution for surface silyl hydrogen or silyl fluoride or by nucleophilic attack of F-18(-) to Si-O-Si bridges. (
  • Characterization of different vitamin E carriers intended for pulmonary drug delivery. (
  • Some of the more popular types of drug carriers include liposomes, polymeric micelles, microspheres, and nanoparticles. (
  • Polymeric micelles are drug carriers formed by the aggregation of some amphiphilic molecule with an amphiphilic block copolymer. (
  • These carriers are comparable to liposomes, however the lack of an aqueous core makes polymeric micelles less accommodating to a wide variety of drugs. (
  • Microspheres are hollow, micron-sized carriers often formed via self-assembly of polymeric compounds which are most often used to encapsulate the active drug for delivery. (
  • Compared to traditional polymeric drug vehicles, these biodegradable dendrimers show excellent advantages especially as drug delivery systems because they are non-toxic. (
  • pH-sensitive unimolecular polymeric micelles: synthesis of a novel drug carrier. (
  • When porous polymeric drug delivery system is placed in contact with appropriate dissolution medium, release of drug to medium must be preceded by the drug dissolution in the water filled pores or from surface and by diffusion through the water filled channels. (
  • Various drug delivery systems, such as liposomes, micelles, emulsions, polymeric micro/nanoparticles have been showing great promise in controlled and targeted drug delivery. (
  • When a porous hydrophobic polymeric drug delivery system is placed in contact with the appropriate dissolution medium, release of drug to medium must be preceded by the drug dissolution in the water filled pores or from surface and by diffusion through the water filled channels [ 18 ]. (
  • 12. Liu H, Farrell S, Uhrich K. Drug release characteristics of unimolecular polymeric micelles. (
  • SLN have been presented as an alternate carrier scheme to emulsions, liposomes and polymeric nanoparticles. (
  • These drug delivery systems are essentially divided into two groups: polymeric nanoparticles and lipid nanoparticles [ 19 - 25 ]. (
  • A magnetic polymeric carrier, composed of biodegradable poly(d,l-lactide) microspheres, maghemite nanoparticles and anti-cancer drug (paclitaxel) was successfully prepared in dichloromethane using high-speed homogenization. (
  • Tekmira, for example, provides the carrier particles (a.k.a lipid nanoparticles) that Alnylam uses for its key experimental drugs for liver cancer (ALN-VSP) and TTR-mediated amyloidosis (ALN-TTR). (
  • Alnylam has filed patents on new carrier particles for RNAi drugs, listing Alnylam scientists as the inventors, according to Alan Carr, a biotech analyst at Needham & Company, who covers Alnylam's stock. (
  • Presumably, if these patents are awarded, Alnylam wouldn't have to pay Tekmira to develop drugs with particles invented by Alnylam scientists. (
  • Where the particles end up in the body, called their biodistribution, is an important parameter used to evaluate safety, optimize dosing and improve drug targeting. (
  • According to the present concept, drug particles are delivered to the lung together with the functional carrier particle that facilitates both the drug transport into the lungs and the penetration of deposited particles through the mucus. (
  • They have been used as stabilizers of functional carrier particles. (
  • Preliminary examination of the required properties of these particles confirms their potential as functional carriers for pulmonary drug delivery. (
  • Results obtained with surface-modified polystyrene particles as model carriers and parenteral fat emulsions are discussed as examples. (
  • The measured surface hydrophobicities of particles and fat emulsions were well in agreement with the in vivo organ distribution data obtained after i. v. injection of the carriers. (
  • Much of the current research involving liposomes is focused on improving the delivery of anticancer drugs such as doxorubicin and paclitaxel. (
  • This review attempts to highlight all aspects of CNTs which render them as an effective anticancer drug carrier and imaging agent. (
  • Also the potential application of CNT in targeting metastatic cancer cells by entrapping biomolecules and anticancer drugs has been covered in this review. (
  • As a new drug delivery system, they have attracted increasing attention for their wide applications in, for example, loading protein drugs, gene drugs, and anticancer chemical drugs, and via various routes of administration including oral, nasal, intravenous, and ocular. (
  • Their further functional studies using HP-a as an anticancer drug carrier demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry. (
  • c) utilization of CLPs as delivery vehicles for the hydrophobic anticancer drug ellipticine (EPT). (
  • Methotrexate (MTX) is widely used as an anticancer and anti-inflammtory drug for treating various types of cancer and autoimmune diseases. (
  • Nanostructured lipid carriers have attracted expanding scientific and commercial vigilance in the last couple of years as alternate carriers for the pharmaceutical consignment, particularly anticancer pharmaceuticals. (
  • It is foreseen that, in the beside future, nanostructured lipid carriers will be further advanced to consign cytotoxic anticancer compounds in a more efficient, exact and protected manner. (
  • Liposomes as injectable drug carriers have been extensively investigated due to their biocompatibility and effective drug encapsulating property. (
  • Owing to their high carrying capacity, biocompatibility, and specificity to cells, various cancer cells have been explored with CNTs for evaluation of pharmacokinetic parameters, cell viability, cytotoxicty, and drug delivery in tumor cells. (
  • Chitosan nanoparticles are good drug carriers because of their good biocompatibility and biodegradability, and can be readily modified. (
  • Resealed erythrocyte have advantage over several drug carrier models like biocompatibility, biodegradability without toxic products, inert intracellular environment, entrapping potential for a variety of chemicals, protection of the organism against toxic effects of the drug, able to circulate throughout the body, ideal zero-order drug-release kinetics, no undesired immune response against encapsulated drug etc. (
  • These dendrimers increase the biocompatibility and increase the tolerance concentration during drug-dendrimer formulations. (
  • Resealed erythrocytes have been explored in various dimensions of drug delivery, owing to their high biocompatibility and inability to initiate immune response. (
  • Because of its biocompatibility and ability to accommodate a variety of payloads from poorly soluble drugs to biomolecules, porous silicon (PSi) is a lucrative material for the development of carriers for particle-mediated drug delivery. (
  • Authors: Alexander A, Agrawal M, Saraf S, Saraf S, Ajazuddin, Chougule MB Abstract NLC is a next-generation lipid nanocarrier which holds many advantages over other colloidal lipid carrier system like higher drug loading, better and controlled release and enhanced stability. (
  • Graphical abstract Morphology and porous characteristics of nanoporous [email protected](ethyleneimine)s xerogel determined its controlled drug release effect. (
  • The ability of lipid carriers to enhance solubility, absorption and thereby the bioavailability of poorly soluble molecules by selective mechanism makes these systems a unique delivery option for certain classes of drugs. (
  • In this chapter, focus will be on different lipid-based carrier systems, their role in nano delivery and the advantages offered in improvement of solubility, absorption, and bioavailability with relevant case studies. (
  • Amidon GL, Lennernäs H, Shah VP, Crison JR (1995) A Theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. (
  • Drug carriers are also used to improve the pharmacokinetic properties, specifically the bioavailability, of many drugs with poor water solubility and/or membrane permeability. (
  • The porous carriers are used to improve the oral bioavailability of poorly water soluble drugs, to increase the dissolution of relatively insoluble powders and conversion of crystalline state to amorphous state. (
  • Low bioavailability often limits the use of promising drug candidates and as a result drugs are potentially used in too high doses. (
  • Lipids being biocompatible and possessing diverse physicochemical properties have tremendous potential to enhance oral bioavailability of water insoluble drugs. (
  • SLN are spherical nanoparticles with a drug-containing solid lipid core stabilized with surfactants and formulated mainly to improve bioavailability of the drug molecules. (
  • The study revealed that KF NPs were capable of releasing the drug for a prolonged period of time and increasing the ocular bioavailability. (
  • Low corneal bioavailability and low efficiency of drug penetration to the posterior segment of ocular tissue are some of the serious drawbacks of these systems. (
  • Decreasing the particle size of drugs has been an effective and valid manner for modifying the bioavailability of insoluble drugs. (
  • But this drug is light sensitive and poorly soluble in water and it affects its bioavailability. (
  • Poor water solubility and insufficient bioavailability of the new drug substances are very widespread issues encountered. (
  • It was demonstrated that NLCs uncover a few points of interest for medication treatment conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, prolonged half-life, reduced adverse effect, and tissue-targeted delivery. (
  • As drug delivery systems, SLNs can enhance bioavailability, protect sensitive drugs from a rigorous environment, and control drug-release attributes [ 32 - 35 ]. (
  • Araújo J, Garcia ML, Mallandrich M, Souto EB, Calpena AC (2012) Release profile and transscleral permeation of triamcinolone acetonide loaded nanostructured lipid carriers (TA-NLC): in vitro and ex vivo studies. (
  • Drugs which have high membrane-permeability can readily 'leak' from the carrier, while optimization of in vivo stability can cause drug release by diffusion to be a slow and inefficient process. (
  • A novel method of delivering a hydrophobic (water-insoluble) drug, in which the compound effectively acts as its own carrier, has shown comparable efficacy both in vitro and in vivo to the same drug formulated in a conventional delivery vehicle. (
  • Emulsions are now not only well established as drug delivery systems of poorly water-soluble drugs, but are also used increasingly as a means of controlling the drugs' kinetics and distribution in vivo. (
  • The purpose of this study was to prepare and characterize nanoporous [email protected](ethyleneimine)s ([email protected]) xerogel and methanol modified [email protected] xerogel synthesized with biomimetic method, and investigate controlled release behavior of propranolol hydrochloride (PNH) loaded carrier materials in vitro and in vivo. (
  • In vivo pharmacokinetic study demonstrated that release of PNH was delayed due to the PNH incorporated inside carrier materials and controlled release effect was in accordance with in vitro results. (
  • We report a successful direct one-step F-18-radiolabeling of three types of PSi microparticles, thermally hydrocarbonized THCPSi, thermally oxidized TOPSi, and thermally carbonized TCPSi for the investigation of their biodistribution in vivo with positron emission tomography as part of their evaluation as carriers for particle-mediated drug delivery. (
  • Finally, a preliminary evaluation of F-18-THCPSi microparticle biodistribution in the rat gastrointestinal tract after oral administration is reported, illustrating the utility of using F-18-radiolabeled PSi as imaging probes for PSi-based drug delivery carrier distribution in vivo. (
  • On the contrary, it is essential to use 2-D PAGE to establish the correlation between adsorbed proteins and carrier behavior in vivo. (
  • Disadvantages associated with using liposomes as drug carriers involve poor control over drug release. (
  • Physical properties and biological interactions of liposomes developed as a drug carrier in the field of regenerative medicine. (
  • Liposomes additionally may extend half-live period of drugs and protect them against the elimination in different ways, such as phagocytosis, enzymatic cleavage or exclusion by detoxification. (
  • The size and charge of liposomes play an important role in drug distribution and absorption into the cell. (
  • Liposomes, niosomes, transferosomes and ethosomes also have been reported to enhance permeability of drug through the stratum corneum barrier. (
  • Drug release is often achieved by diffusion through pores in the microsphere structure or by degradation of the microsphere shell. (
  • Researchers have known for some time that fructans, which are polymers of fructose, are resistant to acid degradation and theorized that they might be a useful drug delivery vehicle. (
  • They chemically modified the fructan compound to allow drugs to be encapsulated, making the drugs resistant to degradation in the digestive system. (
  • The drug can be protected against degradation and its transport at the biological barrier can be altered. (
  • From in vitro degradation tests, it was found that drug-immobilized α-CDs are completely released by hydrolysis of the terminal peptide linkages in the polyrotaxane without any steric hindrance. (
  • One approach to minimizing enzymatic degradation in the GI tract is to target drugs to the apparently less proteolytically active colon. (
  • Employers should submit hair test failures to the Drug and Alcohol Clearinghouse so that drug abusers do not operate commercial trucks on U.S. highways. (
  • The Federal Motor Carrier Safety Administration (FMCSA), in consultation with the Federal Transit Administration (FTA), has issued new guidance via their website (dated Dec. 13, 2019) related to participation in the FMCSA's Drug and Alcohol Clearinghouse by motor carriers and their drivers that provide service subsidized by the FTA. (
  • The U.S. Department of Transportation's (DOT) Federal Motor Carrier Safety Administration (FMCSA) today announced a final rule that establishes a national drug and alcohol clearinghouse for commercial truck and bus drivers. (
  • The drug and alcohol clearinghouse final rule annual net benefits are an estimated $42 million, with crash reductions resulting from annual and pre-employment queries by FMCSA-regulated motor carriers. (
  • Congress directed FMCSA to establish a national drug and alcohol clearinghouse as mandated by the Moving Ahead for Progress in the 21st Century Act (MAP-21). (
  • The national drug and alcohol clearinghouse Final Rule goes into effect in January 2020, three years after its effective date. (
  • To view the drug and alcohol clearinghouse Final Rule, click this link . (
  • To learn more about the drug and alcohol clearinghouse, click on this link . (
  • By my signature below, I hereby provide consent to the United States Postal Service (Postal Service) to conduct the required annual limited queries of the FMCSA Commercial Driver's License Drug and Alcohol Clearinghouse (Clearinghouse) to determine whether drug or alcohol violation information about me exists in the Clearinghouse. (
  • This hydrophobic/hydrophilic composition is particularly useful for drug delivery as these carriers can accommodate a number of drugs of varying lipophilicity. (
  • Since, the polymers were designed as potential delivery systems for the oral administration of hydrophobic drugs, they were titrated to evaluate the degree of ionization as a function of pH. (
  • The pH rise was associated with an increase in the in vitro release rate of progesterone, which was used as hydrophobic drug model. (
  • US researchers from the University of Buffalo (UB) and the Roswell Park Cancer Institute (RPCI) believe the technique, which could move swiftly into clinical trials, offers significant cost and toxicity advantages over the surfactant or other carrier vehicles commonly used to ensure the stable dispersion of hydrophobic agents into aqueous systems. (
  • Both drugs are hydrophobic, meaning they dislike water and shy away from it. (
  • The present research was designed to evaluate the drug delivery potential of erythrocytes by loading a hydrophobic anti-malarial drug, Artemether. (
  • Overall, the study revealed a potential application of erythrocytes in delivery of hydrophobic drugs using hypotonic treatment as compared to other methods. (
  • Hydrophobic interaction chromatography (HIC) is presented as a suitable method to determine the surface hydrophobicity of colloidal drug carriers. (
  • Different types of delivery systems that include liposome, solid lipid nanoparticles, nanostructured lipid carriers, lipid-polymer hybrid nanoparticles, lipoplexes, and phytosomes can be produced depending on the lipids/excipients used and the formulation technique employed. (
  • Aditya NP, Macedo AS, Doktorovova S et al (2014) Development and evaluation of lipid nanocarriers for quercetin delivery: a comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE). (
  • Two examples of innovative lipid-based nanoparticle drug delivery technologies are solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). (
  • In recent years, two lipid based nanoparticles, namely solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are widely explored. (
  • Contrasted to SLN, NLC show a higher loading capability for hardworking compounds by conceiving a less organized solid lipid matrix, i.e. by blending a fluid lipid with the solid lipid, a higher element drug stacking can be achieved. (
  • The team, led by Ester Segal of the Technion-Israel Institute of Technology with members from MIT, has used silicon nanocarriers to carry and release chemotherapy drugs for several years now, according to an American Technion Society release. (
  • During recent years, novel carriers for the delivery of targeted drugs, chemotherapy drugs and RNAs are under development, which is believed to be beneficial for patients. (
  • By ensuring anti-cancer drugs reach their target in controlled, coordinated doses, nanodaisies could cut down on the side effects of traditional chemotherapy. (
  • The available therapeutic options, such as chemotherapy and radiotherapy, need skilled personnel to lead to better results from the target-specificity of the drug(s) in question. (
  • Pramod Kumar, Kaisar Raza, Lokesh Kaushik, Ruchi Malik, Shweta Arora and Om Prakash Katare, "Role of Colloidal Drug Delivery Carriers in Taxane-mediated Chemotherapy: A Review", Current Pharmaceutical Design (2016) 22: 5127. (
  • 8. Kabanov A, Batrakova E, Alakhov V. Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery. (
  • With reduced branching, it represents an ideal precursor for targeting ligand conjugation in design of oral colon-specific nanoparticulate drug carrier. (
  • Drug delivery systems would allow more precise targeting of diseased tissue, thus making medicines more effective and requiring lower doses with fewer side effects. (
  • In this pharma innovative world, there are more than 30 drug delivery systems. (
  • Today's due to lacking the target specificity, the present scenario about drug delivery is emphasizing towards targeted drug delivery systems. (
  • Owing to wide range of useful properties porous carriers have been used in pharmaceuticals for many purposes including development of floating drug delivery systems, sustained drug delivery systems. (
  • Owing to wide range of useful properties, porous carriers have been used in pharmaceuticals for many purposes including development of novel drug delivery systems such as floating drug delivery system, sustained drug delivery system and improvement of solubility of poorly soluble drugs [ 9 - 14 ]. (
  • The report covers the currently available drug delivery technologies and recent advances in the field, with granular analyses of the different types of delivery systems, their advantages, disadvantages and opportunities for future development. (
  • Key factors promoting growth include the rapidly expanding injectables market, the growing incidence of chronic diseases and the expected significant increase in the use of complex biologic drugs that necessitate novel delivery systems. (
  • Effective and compound-sparing methods to evaluate promising drug delivery systems are a prerequisite for successful selection of formulations in early development stages. (
  • The method is a valuable addition to the current ones, allowing for fast and effective evaluation of advanced drug delivery systems. (
  • Drug Targeting and Stimuli Sensitive Drug Delivery Systems. (
  • In this paper, we have made a coordinated effort to show the potential of novel drug delivery systems by achieving effective and target-specific delivery of methotrexate. (
  • The traditional drug delivery systems earned popularity due to their economic, simple, and user-friendly approach, but recently developed specific drug-delivery systems, such as lipid-polymer hybrid nanoparticles ( 1 ), have drawn attention due to their target-specificity, effectiveness, and fewer adverse effects. (
  • Despite initial obstacles to the use of novel drug-delivery systems (NDDS), the nanotechnology helps in achieving maximum drug therapeutics. (
  • The most prominent advantage of nanoscaled drug carriers over conventional drug delivery systems is the option to improve selective delivery of drugs to the site of action, so-called drug targeting which can be classified into the active and passive targeting approaches. (
  • The use of lipid-based drug delivery systems in pharmaceutical product development is increasing due to the versatility of functional lipid excipients and the compatibility of these excipients with liquid, semi-solid, and solid pharmaceutical dosage forms. (
  • 2-5 Although the applications of functional lipids as excipients and drug delivery systems for the pharmaceutical industry has been understood for quite some time, novel features of functional lipids continue to be discovered and employed in ever-emerging drug delivery systems. (
  • SLN and NLC formulations maintain the enhanced solubility benefits of traditional liquid colloidal carrier drug delivery systems, but provide several additional benefits, such as increased chemical stability for the Active Pharmaceutical Ingredient (API), potential for sustained release, targeted delivery, and lymphatic delivery, which allows for the avoidance of first-pass metabolism as well as lymphatic targeting. (
  • He has extensive experience in the development of solid oral dosage forms, including the development of multiple direct compression, drug delivery systems, and formulations. (
  • However, there have been several attempts to develop toxic solvent free taxane formulations, especially employing novel drug delivery systems (NDDS). (
  • 2, Gastro-Retentive Floating Drug Delivery Systems: A Critical Review. (
  • Nanostructured lipid carriers (NLCs) are drug-delivery systems and they are made out of solid and fluid lipids as a core matrix. (
  • A promising way to deal with beating this issue is the improvement of feasible drug-delivery systems. (
  • Microemulsions are excellent candidates as potential drug delivery systems because of their improved drug solubilization, long shelf life, and ease of preparation and administration. (
  • Certain trucking companies are being randomly selected by the Federal Motor Carrier Safety Administration to submit their 2016 U.S. DOT drug testing results to the agency. (
  • Methods used in study of ethics of infection control measures for carriers of antimicrobial-resistant organisms, the Netherlands, January 1, 2008-January 16, 2016. (
  • One J-15 crashed during a land-based carrier landing test in April 2016 due to flight control system failures, and a pilot sustained grave injuries and later died as he tried to regain control of the aircraft and only ejected at the last minute. (
  • Some of the research currently being done uses advanced assembly techniques, such as precision particle fabrication (PPF), to create microspheres capable of sustained control over drug release. (
  • The tequila compounds, a class of polysaccharides known as fructans, were developed by the scientists in Mexico into tiny microspheres that are capable of carrying existing drugs that are used to treat colon diseases. (
  • The researchers then prepared microspheres of the compounds and filled them with ibuprofen as a model of drug delivery to the colon. (
  • The following research papers from IUPAC are in pdf format: Biodegradable hydrogels for bone regeneration through growth factor release Development of acid-sensitive copolymer micelles for drug delivery Svenson, Sönke (2004). (
  • 11. Liu M, Kono K, Frechet J. Water-soluble dendritic unimolecular micelles: their potential as drug delivery agents. (
  • 13. Kwon G, Naito M, Yokoyama M, Okano T, Sakurai Y, Kataoka K. Block copolymer micelles for drug delivery: loading and release of doxorubicin. (
  • The Department of Health and Human Services (HHS) was given one year to deliver testing guidelines to DOT, so that motor carriers could quickly utilize hair testing rather than the less effective urine test in their truck driver hiring protocols. (
  • Additionally, motor carriers will be required to annually search the clearinghouse for current employees, and during the pre-employment process for prospective employees, to determine whether a driver violated drug or alcohol testing requirements with a different employer that would prohibit them from operating a CMV. (
  • Motor carriers are prohibited from allowing employees to perform safety-sensitive functions, which include operating a CMV, if the employee tests positive on a DOT drug or alcohol test. (
  • A wide variety of drug carrier systems have been developed and studied, each of which has unique advantages and disadvantages. (
  • What Are the Various Advantages, Limitations & Applications of the Currently Available Drug Carriers? (
  • Two major benefits of fibrous shape have been identified for pulmonary administration, promising advantages over conventional drug carriers. (
  • Despite several advantages of SLNs, their major drawbacks include limited drug loading, drug leakage, and crystallization during storage. (
  • Nanosuspension has appeared as an efficient and favorable tactic for delivery of insoluble drugs due to its distinctive advantages such as simple improving, procedure flexibility, targeting abilities, and changed pharmacokinetic profile. (
  • New surface hydroxylated and internally quaternised poly(propylene imine) dendrimers as efficient biocompatible drug carriers of norfloxacin. (
  • This study intended to describe the development of two novel, biocompatible and potential surface hydroxylated quaternary ammonium chloride based poly(propylene imine) (PPI) dendrimers for effective delivery of the drug Norfloxacin (NFN). (
  • These results indicate that the QPPI-OH (G2) and QPPI-OH (G3) dendrimers might be considered as potential biocompatible drug carriers of fluoroquinolines under suitable conditions. (
  • Our results suggest that DNA origami has immense potential as an efficient, biocompatible drug carrier and delivery vehicle in the treatment of cancer. (
  • The biocompatible hydrogel alginate, degrading as a function of the phosphate concentration, was utilized in order to form the backbone of the carrier system. (
  • NLC disclosed some benefits contrasted to the other colloidal carrier schemes. (
  • From October 2014 through September 2017, he accepted bribes from two people who were getting parcels containing illegal drugs through the mail. (
  • The 2018 Gordon Conference on Drug Carriers in Medicine and Biology builds on a rich tradition encompassing chemical, biological, physical and engineering principles through clinical application. (
  • Here we present a novel drug carrier system based on self-assembled, spatially addressable DNA origami nanostructures that confronts these limitations. (
  • A novel drug carrier and gene vector PEG-PEI-Pt was constructed successfully. (
  • In this review, we summarize several organic and inorganic PS carriers that have been studied to enhance the efficacy of photodynamic therapy against cancer. (
  • Anti-bacterial studies showed that the efficacy of the drug was increased in the presence of dendrimer carriers. (
  • To promote chemotherapeutic efficacy, a dynamic drug delivery system was prepared, which remained stealthy and stable in blood vessels, improved drug penetration and retention in response to extracellular stimuli, enhanced membrane permeability through unique functional groups, and then achieved rapid drug release to improve toxicity to tumor cells in response to intracellular stimuli. (
  • We confirmed drug efficacy by measuring the uptake of control markers for the pathways involved by flow cytometry and fluorescence microscopy. (
  • The aim of achieving the utmost therapeutic efficacy with the fewest drug hazards is always a priority for any pharmaceutical researcher. (
  • Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits provides a unique and complete overview of novel formulation strategies for improvement of the delivery of NSAIDs via encapsulation in microsized and nanosized carriers composed of different materials of natural and synthetic origin. (
  • This book presents the latest research on advances and limitations of both microsized and nanosized drug carriers and NSAIDs before discussing the formulation aspects of these drug carriers that are intended for oral, dermal, and transdermal administration of NSAIDs. (
  • Formulation strategies of nano lipid carrier for effective brain targeting of anti-AD drugs. (
  • The mechanism of drug release for best formulation was found to be fickian diffusion mechanism. (
  • Recent advances in solid dispersions and the formulation of poorly absorbed drugs. (
  • Drug carriers are primarily used to control the release of a drug into systemic circulation. (
  • This can be accomplished either by slow release of the drug over a long period of time (typically diffusion) or by triggered release at the drug's target by some stimulus, such as changes in pH, application of heat, and activation by light. (
  • A new study from American and Israeli researchers has shown that nanostructures used to deliver cancer drugs act differently within the local area of a tumor than they do in healthy cells, a finding that could change the way these nanomaterials are made and how they target their drug release. (
  • Various types of pores like open, closed, transport and blind pores in the porous solid allow them to adsorb drugs and release them in a more reproducible and predictable manner. (
  • Delivery of drugs by means of controlled release technology began in the 1970s and has continued to expand rapidly [ 2 ]. (
  • These features allow them to adsorb drugs and release them in a more reproducible and predictable manner. (
  • Drug release from the porous carrier may be complete within 10 min or be incomplete after several hours or days. (
  • Solvent polarity and surface properties play an important role in the adsorption and release from the porous carriers [ 19 , 20 ]. (
  • The potential of these dendrimers were examined as drug carrier for NFN, by carrying out solubility, in vitro release, cytotoxicity and anti-bacterial studies. (
  • The aim of the study was to develop a small-scale in situ method to determine drug release and supersaturation in highly concentrated suspensions of enabling formulations. (
  • The μDiss Profiler was used to study the drug release from MMC in fasted-state simulated intestinal fluid. (
  • Three types of release experiments were conducted for each compound: micronized crystalline drug with MMC present, drug-loaded MMC, and drug-loaded MMC with 0.01% w / w hydroxypropyl methyl cellulose. (
  • and (iv) sensitivity to tumoral intracellular pH following dissolution or further swelling for rapid drug release. (
  • Once injected into the bloodstream, millions of these "nanodaisies" sneak inside cancer cells and release a cocktail of drugs to destroy them from within. (
  • The design of the nanodaisy also ensures that the two cancer drugs release at complementary speeds as their carrier comes apart inside the cancer cell. (
  • Drug release was studied for 8 h which showed more than 80% release within 3-7 h from erythrocytes treated with different hypotonic methods. (
  • Modulation of drug release was added advantage with NLC formulations. (
  • Ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtaining controlled release to improve the anti-inflammatory drug delivery. (
  • Drug release for all formulations after 24 hr was between 65.51% and 88.82% indicating effective controlled release property of KF. (
  • on the contrary, nanoparticles containing low polymer concentration (1:7.5) were able to give a more sustained release of the drug and thus a slower KF permeation through the cornea. (
  • The three methods show a release of the drug but one is preferred. (
  • Based on this characteristic, we have introduced a model drug (theophylline) into the α-CDs in the polyrotaxane to examine drug release via the supramolecular dissociatio … More n. (
  • ConclusionResults confirm that NLC structure is an appropriate alternative for the delivery of ceftriaxone drug with a controlled release behavior. (
  • PNH loaded carrier materials displayed controlled release, and release effect was related with pore size of materials and PEIs scaffold ability. (
  • These nanoparticles were subjected to size, zeta potential, morphology, drug content and in vitro drug release analysis. (
  • The nanoparticles prepared from resistant starch demonstrated similar drug release as those of native starch in spite of the resistant starch had a lower molecular weight. (
  • The resistant starch is envisaged to be resistant to the digestive action of amylase in intestinal tract without the formed nanoparticles exhibiting excessively fast drug release in comparison to native starch. (
  • In this review the benefits, types, drug release modulations, steadiness and output techniques of NLCs are discussed. (
  • This carrier scheme should be free of toxicity, have an adequate pharmaceutical loading capability and the possibility of pharmaceutical targeting and controlled release characteristics. (
  • These ethosomes permeates inside the skin and fuse with cell membrane lipids and release the drug. (
  • Alternating movement of the nanoparticles, stimulated by magnetic force, resulting in deterioration of the mechanical properties of polymer matrix was likely to be the main reason for the enhancement in drug release. (
  • The targeted release of drugs intended for pulmonary delivery is a research field which has been so far rather unexploited but is currently becoming increasingly attractive. (
  • CHICAGO, March 27 -- Compounds derived from the blue agave, a fruit used to make tequila, shows promise in early laboratory studies as a natural, more effective way to deliver drugs to the colon than conventional drug-carriers, according to chemists at the University of Guadalajara in Mexico. (
  • Since conventional carrier systems are not formed within precisely defined templates, such as the track-etched membranes with cylindrical pores used herein, the geometry is less defined. (
  • Despite their largely irregular shape, conventional carriers are described as spherical. (
  • Incorporation of a drug in lipid carriers is a smart approach to overcome problems related with conventional oral therapy. (
  • In conventional ophthalmic dosage forms, water soluble drugs are delivered in aqueous solution while water insoluble drugs are formulated as suspensions or ointments. (
  • Considering issues of drug nano-formulations in bloodstream, such as nano-toxicity and rapid clearance by mononuclear phagocyte system, exosomes derived from either patient's cells or bodyfluids, seem to be an optimal option. (
  • 5. Valenta C, Wanka M, Heidlas J. Evaluation of novel soyalecithin formulations for dermal use containing ketoprofen as a model drug. (
  • Most of these concerns are ascribable to the presence of toxic solvents in these commercial formulations, which are used to solubilize these drug(s). (
  • Overwhelming purposes behind this disappointment are the deficient drug concentration in the body as a result of quick metabolism system, the high medication poisonous quality as a result of extensive distribution, poor drug dissolvability in formulations, and high change or inter subject variability of plasma medication or drug levels [ 1 - 11 ]. (
  • Get Nanostructures for Drug Delivery now with O'Reilly online learning. (
  • Core-Shell Nanostructures for Drug Delivery and Theranostics. (
  • By using one nanocarrier to contain two different drugs, we can potentially reduce their dose and toxicity," said Dr. Zhen Gu, assistant professor in the Joint Department of Biomedical Engineering at NC State and UNC-Chapel Hill. (
  • Nanoparticles take advantage of unique characteristics, such as the enhanced permeation and retention (EPR) effect, a large surface-to-volume ratio, extended residence time in circulation, biodegradability, low toxicity, and small size in the range of 10-500 nm, thus conferring sustained and targeted drug delivery ( 9 , 10 ). (
  • Vesicular system is one of the most controversial methods for transdermal delivery of active substances in that ethosome are the ethanolic phospholipids vesicles which are used mainly for transdermal delivery of drugs. (
  • Different methods of attaching the drug to the carrier have been implemented, including adsorption, integration into the bulk structure, encapsulation, and covalent bonding. (
  • Thanks to their high surface area and their high pore volume, it is possible to load a large quantity of drug inside the pores via adsorption. (
  • Researchers have tried to circumvent this problem by inserting the drugs into carrier molecules that resist breakdown in the stomach but have had difficulty finding a suitable carrier compound. (
  • Selected drug molecules with Lewis base functions can be assembled into coordinative nanoparticles (NPs) by linking them with suitable metal ions. (
  • The metal‐drug NP core is assembled in a bottom‐up approach by coordinative interactions between zirconium (IV) ions and PMX molecules. (
  • This survey depicts developments in drug delivery utilizing NLCs procedures. (
  • The related licenses of NLCs for drug delivery are additionally checked on. (
  • At the turn of the thousand years, nanostructured lipid carriers (NLCs) were designed to resolve, at times, the issues raised by SLNs. (
  • In this review we might want to demonstrate the present development of NLCs for drug delivery and the focusing on application. (
  • Random carriers are being selected by FMCSA to participate in the agency's annual Drug and Alcohol Information Survey. (
  • In December, FMCSA announced it would keep the random drug testing rate for drivers at 25 percent based on information provided in last year's survey. (
  • The agency requested that DOT's Federal Motor Carrier Safety Administration (FMCSA) "gather data on the prevalence of commercial motor vehicle driver use of impairing substances and to consider alternative drug testing methods. (
  • Despite the authority Congress gave DOT, FMCSA will not today disqualify a truck driver for failing a hair test for drug use. (
  • As a general rule, a carrier and its drivers that operate service funded under 49 USC 5307, 5309 or 5311 are subject to the FTA's drug and alcohol testing requirements and are not subject to the similar requirements of the FMCSA. (
  • The Federal Drug Testing Custody and Control Form (CCF) specifies the DOT agency requesting the test, and employers may only report to the Clearinghouse a positive result when FMCSA is the agency designated on the CCF. (
  • Carriers must make an annual query of the Clearinghouse database for any driver that performed any FMCSA-regulated work in the previous year. (
  • Earlier this summer, MVS announced a National Dispute on the Postal Service's unilateral implementation of Federal Motor Carrier Safety Administration (FMCSA) Clearinghouse Consent Form and Program. (
  • The effects of the ASMs on percutaneous permeation of nonsteroidal anti-inflammatory drugs (NSAIDs) across full thickness, hairless mouse skin were evaluated in vitro using modified Franz diffusion cells. (
  • Moreover, the surface of NLC can be easily modified with target-specific ligands, proteins, peptides, etc. which makes it a potential candidate for brain targeting of CNS acting drugs. (
  • There is a growing interest in the use of cell-penetrating peptides (CPPs) as carriers for transepithelial drug delivery. (
  • The physiological conditions in the peripheral lung with scarce lining fluid, acting as the solvent, and low enzymatic activity of the fragile tissue largely restrict the selection of compounds for the design of pulmonary carriers. (
  • The past decade has seen enormous activity in research on drug delivery and targeting using emulsions. (
  • By enabling more selective delivery to particular organs or tissues, emulsions are promising to improve the therapeutic index of drugs. (
  • New Scientist - DNA Origami Trojan horse was used delivered a dose of the drug that proved lethal to human breast-cancer cells, even though they had developed resistance to doxorubicin. (
  • Doxorubicin, a well-known anti-cancer drug, was non-covalently attached to DNA origami nanostructures through intercalation. (
  • A high level of drug loading efficiency was achieved, and the complex exhibited prominent cytotoxicity not only to regular human breast adenocarcinoma cancer cells (MCF 7), but more importantly to doxorubicin-resistant cancer cells, inducing a remarkable reversal of phenotype resistance. (
  • With the DNA origami drug delivery vehicles, the cellular internalization of doxorubicin was increased, which contributed to the significant enhancement of cell-killing activity to doxorubicin-resistant MCF 7 cells. (
  • Presumably, the activity of doxorubicin-loaded DNA origami inhibits lysosomal acidification, resulting in cellular redistribution of the drug to action sites. (
  • A second drug, doxorubicin, also floats in solution around the PEG. (
  • Now that we understand the basics of nanoparticle drug delivery, let's see a demonstration that uses high-resolution imaging to determine the biodistribution of metallic nanoparticles in a mouse model. (
  • Such nanomaterials exhibit a high material economy due to high drug contents and minor amounts of inactive additives. (
  • Manufacturing methods of different carrier systems will be elaborated with a brief overview of scale up feasibility. (
  • BERKELEY, Calif.--(BUSINESS WIRE)--DSM, a global leader in biomedical materials, and Svelte® Medical Systems, Inc., a privately held company developing next generation endovascular therapies, today announced they have entered into a license and supply agreement granting Svelte the right to use DSM's proprietary bioerodible amino acid based drug carrier in the design of a non-thrombogenic, non-inflammatory drug-eluting stent. (
  • Production of collagen micro- and nanofibers for potential drug-carrier systems. (
  • In the past decades, a few methodologies have been studied to develop or create nanosized drug- carrier systems [ 12 - 18 ]. (
  • In this article, we present an examination of microemulsions as drug carrier systems, starting with general information and moving to a thorough review of the microemulsion literature, with a special section devoted to microemulsion-based gels. (
  • Novel mechanisms and devices to enable successful transdermal drug delivery. (
  • Transdermal drug delivery system is a type of convenient drug delivery system where drug goes to the systemic circulation through the protective barrier i.e. (
  • Skin acts as a major target as well as a principal barrier for topical / transdermal drug delivery. (
  • Transdermal drug delivery generated tremendous excitement and interest amongst major pharmaceutical companies in the 1980s and 90s. (
  • By the mid to late 1990s, the trend of transdermal drug delivery system merged into larger organizations. (
  • Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications. (
  • The goal of any drug delivery system is to provide the therapeutic amounts of drug to the proper site in the body to achieve promptly and to maintain the desired drug concentration [ 1 ]. (
  • Colloidal carriers allow one to improve delivery of drugs to the site of action and appear promising to overcome this general therapeutic drawback. (
  • Only 1-5% of the utilized drug penetrates into the cornea and achieves therapeutic concentra-tions in intraocular tissues. (
  • With the purpose of improving the therapeutic index of $[^3H]$ acyclovir (ACV) in the treatment of chronic hepatitis B infection, asialofetuin (AF) which after selective interaction with Ashwell's receptor specifically enters into hepatocytes, was chosen as a carrier system for hepatic targeting. (

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