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DriveModels, BiologicalSignal TransductionMolecular Sequence DataPromoter Regions, GeneticMice, TransgenicRespirationMutationMice, Inbred C57BLBase SequenceNeuronsMotor NeuronsAnimals, Genetically ModifiedElectromyographyGene Expression Regulation, DevelopmentalAction PotentialsCells, CulturedTranscription FactorsTime FactorsGreen Fluorescent ProteinsGene Expression RegulationCell DifferentiationMice, KnockoutRespiratory MechanicsBiological EvolutionSex RatioProtein BindingDrosophila ProteinsRespiratory CenterGenes, ReporterTransgenesPeriodicityMeiosisCell ProliferationInhalationLicensureBiological ClocksDrosophila melanogasterCell Line, TumorSelection, GeneticAmino Acid SequenceCell LineProtein Structure, TertiaryDrosophilaPhrenic NerveTranscription, GeneticHypoglossal NerveModels, GeneticEvolution, MolecularCell MovementEmbryo, NonmammalianCarbon DioxideModels, MolecularElectric StimulationRespiratory MusclesHypercapniaZebrafishApneaComputer SimulationBinding SitesMuscle, SkeletalPhenotypeEcosystemDNA-Binding ProteinsDisease Models, AnimalMembrane ProteinsMovementNeural PathwaysFeedback, PhysiologicalRecombinant Fusion ProteinsModels, NeurologicalBrain StemInterneuronsRats, Sprague-DawleyMolecular Motor ProteinsNeural InhibitionRNA, MessengerSynapsesNerve NetSynaptic TransmissionEfferent PathwaysProtein TransportActinsLocomotionAnimals, NewbornGene ExpressionEnhancer Elements, GeneticCircadian RhythmAdaptation, PhysiologicalDiaphragmHomeodomain ProteinsTransfectionSpecies SpecificityPopulation DynamicsSpinal CordElectrophysiologyNuclear ProteinsKinesinGene Expression ProfilingMedulla OblongataRNA InterferenceGenes, InsectAdenosine TriphosphateCell MembranePhylogenyMorphogenesisAnalysis of VarianceReverse Transcriptase Polymerase Chain ReactionExcitatory Postsynaptic PotentialsLuminescent ProteinsMyosin Type IICell PolarityKineticsBacterial ProteinsMicroscopy, FluorescenceSex ChromosomesBehavior, AnimalMicroscopy, ConfocalCell ShapeTrans-ActivatorsPhosphorylationCell Transformation, NeoplasticNeuronal PlasticityDNA PrimersBrainGenetic SpeciationAdenosine TriphosphatasesTonguePatch-Clamp TechniquesMice, Inbred BALB CImmunohistochemistryBiomechanical PhenomenaAfferent PathwaysGene Expression Regulation, NeoplasticCrosses, GeneticSympathetic Nervous SystemLarvaBlotting, WesternRespiratory Physiological ProcessesProtein ConformationNerve Tissue ProteinsMuscle ContractionSexual Behavior, AnimalRecruitment, NeurophysiologicalGenetic VectorsCatsReflexGenetic VariationAlgorithmsDendritic CellsMicrotubulesDNAGlutamic AcidEpithelial CellsFlow CytometryModels, TheoreticalLymphocyte ActivationNeoplasmsInflammationPseudopodiaReproductionBody PatterningProtein MultimerizationSequence Analysis, DNASwimmingAdaptation, BiologicalUp-RegulationCell CycleMembrane PotentialsZebrafish ProteinsCarrier ProteinsHomeostasisTidal VolumeRecombination, GeneticTemperatureOrgan SpecificityRNA, Small InterferingHEK293 CellsApoptosisCell NucleusIn Situ HybridizationBasic Helix-Loop-Helix Transcription FactorsPulmonary VentilationPlasmidsCell LineageStem CellsTranscriptional ActivationSaccharomyces cerevisiae ProteinsT-LymphocytesCoculture TechniquesActomyosinSequence AlignmentDecerebrate StateRegulatory Sequences, Nucleic AcidEscherichia coliExcitatory Amino Acid AntagonistsConserved SequenceRepressor ProteinsGene DeletionLac OperonRespiratory System
Drive: A state of internal activity of an organism that is a necessary condition before a given stimulus will elicit a class of responses; e.g., a certain level of hunger (drive) must be present before food will elicit an eating response.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Respiration: The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Mice, Inbred C57BLBase Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Motor Neurons: Neurons which activate MUSCLE CELLS.Animals, Genetically Modified: ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.Electromyography: Recording of the changes in electric potential of muscle by means of surface or needle electrodes.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Action Potentials: Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Green Fluorescent Proteins: Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Respiratory Mechanics: The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.Biological Evolution: The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.Sex Ratio: The number of males per 100 females.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Drosophila Proteins: Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.Respiratory Center: Part of the brain located in the MEDULLA OBLONGATA and PONS. It receives neural, chemical and hormonal signals, and controls the rate and depth of respiratory movements of the DIAPHRAGM and other respiratory muscles.Genes, Reporter: Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.Transgenes: Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.Periodicity: The tendency of a phenomenon to recur at regular intervals; in biological systems, the recurrence of certain activities (including hormonal, cellular, neural) may be annual, seasonal, monthly, daily, or more frequently (ultradian).Meiosis: A type of CELL NUCLEUS division, occurring during maturation of the GERM CELLS. Two successive cell nucleus divisions following a single chromosome duplication (S PHASE) result in daughter cells with half the number of CHROMOSOMES as the parent cells.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Inhalation: The act of BREATHING in.Licensure: The legal authority or formal permission from authorities to carry on certain activities which by law or regulation require such permission. It may be applied to licensure of institutions as well as individuals.Biological Clocks: The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.Cell Line, Tumor: A cell line derived from cultured tumor cells.Selection, Genetic: Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Phrenic Nerve: The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Hypoglossal Nerve: The 12th cranial nerve. The hypoglossal nerve originates in the hypoglossal nucleus of the medulla and supplies motor innervation to all of the muscles of the tongue except the palatoglossus (which is supplied by the vagus). This nerve also contains proprioceptive afferents from the tongue muscles.Models, Genetic: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Embryo, Nonmammalian: The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.Carbon Dioxide: A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Electric Stimulation: Use of electric potential or currents to elicit biological responses.Respiratory Muscles: These include the muscles of the DIAPHRAGM and the INTERCOSTAL MUSCLES.Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.Zebrafish: An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.Apnea: A transient absence of spontaneous respiration.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Ecosystem: A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Movement: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.Neural Pathways: Neural tracts connecting one part of the nervous system with another.Feedback, Physiological: A mechanism of communication with a physiological system for homeostasis, adaptation, etc. Physiological feedback is mediated through extensive feedback mechanisms that use physiological cues as feedback loop signals to control other systems.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Models, Neurological: Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Brain Stem: The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.Interneurons: Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Molecular Motor Proteins: Proteins that are involved in or cause CELL MOVEMENT such as the rotary structures (flagellar motor) or the structures whose movement is directed along cytoskeletal filaments (MYOSIN; KINESIN; and DYNEIN motor families).Neural Inhibition: The function of opposing or restraining the excitation of neurons or their target excitable cells.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Synapses: Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.Nerve Net: A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.Synaptic Transmission: The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.Efferent Pathways: Nerve structures through which impulses are conducted from a nerve center toward a peripheral site. Such impulses are conducted via efferent neurons (NEURONS, EFFERENT), such as MOTOR NEURONS, autonomic neurons, and hypophyseal neurons.Protein Transport: The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Locomotion: Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.Animals, Newborn: Refers to animals in the period of time just after birth.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Enhancer Elements, Genetic: Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.Circadian Rhythm: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.Adaptation, Physiological: The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.Diaphragm: The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.Homeodomain Proteins: Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Population Dynamics: The pattern of any process, or the interrelationship of phenomena, which affects growth or change within a population.Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Kinesin: A microtubule-associated mechanical adenosine triphosphatase, that uses the energy of ATP hydrolysis to move organelles along microtubules toward the plus end of the microtubule. The protein is found in squid axoplasm, optic lobes, and in bovine brain. Bovine kinesin is a heterotetramer composed of two heavy (120 kDa) and two light (62 kDa) chains. EC 3.6.1.-.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Medulla Oblongata: The lower portion of the BRAIN STEM. It is inferior to the PONS and anterior to the CEREBELLUM. Medulla oblongata serves as a relay station between the brain and the spinal cord, and contains centers for regulating respiratory, vasomotor, cardiac, and reflex activities.RNA Interference: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.Genes, Insect: The functional hereditary units of INSECTS.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Morphogenesis: The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Excitatory Postsynaptic Potentials: Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS.Luminescent Proteins: Proteins which are involved in the phenomenon of light emission in living systems. Included are the "enzymatic" and "non-enzymatic" types of system with or without the presence of oxygen or co-factors.Myosin Type II: The subfamily of myosin proteins that are commonly found in muscle fibers. Myosin II is also involved a diverse array of cellular functions including cell division, transport within the GOLGI APPARATUS, and maintaining MICROVILLI structure.Cell Polarity: Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains.Kinetics: The rate dynamics in chemical or physical systems.Bacterial Proteins: Proteins found in any species of bacterium.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Sex Chromosomes: The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Behavior, Animal: The observable response an animal makes to any situation.Microscopy, Confocal: A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.Cell Shape: The quality of surface form or outline of CELLS.Trans-Activators: Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Neuronal Plasticity: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Genetic Speciation: The splitting of an ancestral species into daughter species that coexist in time (King, Dictionary of Genetics, 6th ed). Causal factors may include geographic isolation, HABITAT geometry, migration, REPRODUCTIVE ISOLATION, random GENETIC DRIFT and MUTATION.Adenosine Triphosphatases: A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.Tongue: A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.Patch-Clamp Techniques: An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.Mice, Inbred BALB CImmunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.Afferent Pathways: Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Crosses, Genetic: Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.Sympathetic Nervous System: The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.Larva: Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Respiratory Physiological Processes: Biological actions and events that support the functions of the RESPIRATORY SYSTEM.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Nerve Tissue ProteinsMuscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Sexual Behavior, Animal: Sexual activities of animals.Recruitment, Neurophysiological: The spread of response if stimulation is prolonged. (Campbell's Psychiatric Dictionary, 8th ed.)Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Reflex: An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.Genetic Variation: Genotypic differences observed among individuals in a population.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).Microtubules: Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Models, Theoretical: Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Pseudopodia: A dynamic actin-rich extension of the surface of an animal cell used for locomotion or prehension of food.Reproduction: The total process by which organisms produce offspring. (Stedman, 25th ed)Body Patterning: The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.Protein Multimerization: The assembly of the QUATERNARY PROTEIN STRUCTURE of multimeric proteins (MULTIPROTEIN COMPLEXES) from their composite PROTEIN SUBUNITS.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Swimming: An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.Adaptation, Biological: Changes in biological features that help an organism cope with its ENVIRONMENT. These changes include physiological (ADAPTATION, PHYSIOLOGICAL), phenotypic and genetic changes.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Zebrafish Proteins: Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Homeostasis: The processes whereby the internal environment of an organism tends to remain balanced and stable.Tidal Volume: The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.HEK293 Cells: A cell line generated from human embryonic kidney cells that were transformed with human adenovirus type 5.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Basic Helix-Loop-Helix Transcription Factors: A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.Pulmonary Ventilation: The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Cell Lineage: The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Transcriptional Activation: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.Saccharomyces cerevisiae Proteins: Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Coculture Techniques: A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.Actomyosin: A protein complex of actin and MYOSINS occurring in muscle. It is the essential contractile substance of muscle.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Decerebrate State: A condition characterized by abnormal posturing of the limbs that is associated with injury to the brainstem. This may occur as a clinical manifestation or induced experimentally in animals. The extensor reflexes are exaggerated leading to rigid extension of the limbs accompanied by hyperreflexia and opisthotonus. This condition is usually caused by lesions which occur in the region of the brainstem that lies between the red nuclei and the vestibular nuclei. In contrast, decorticate rigidity is characterized by flexion of the elbows and wrists with extension of the legs and feet. The causative lesion for this condition is located above the red nuclei and usually consists of diffuse cerebral damage. (From Adams et al., Principles of Neurology, 6th ed, p358)Regulatory Sequences, Nucleic Acid: Nucleic acid sequences involved in regulating the expression of genes.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Excitatory Amino Acid Antagonists: Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.Conserved Sequence: A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.Repressor Proteins: Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.Gene Deletion: A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.Lac Operon: The genetic unit consisting of three structural genes, an operator and a regulatory gene. The regulatory gene controls the synthesis of the three structural genes: BETA-GALACTOSIDASE and beta-galactoside permease (involved with the metabolism of lactose), and beta-thiogalactoside acetyltransferase.Respiratory System: The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.

Drug addiction as drive satisfaction ("antidrive") dysfunction. (1/52)

Drug addiction is a complex brain disorder, characterized by the loss of control over drug seeking and drug taking behavior, and by the risk of relapse, even after a prolonged period of abstinence. This disorder may have its source in a disturbed balance of drive-related behaviors, which control appetitive reactions aimed at seeking contact with an addictive substance. The act of consumption becomes more and more attractive, and the behavior takes on compulsive character. We suppose that drug addiction may involve a change in the mechanism of satisfaction of drives and states of satiation as well. To understand how the motivational processes are changed with the development of dependence, one must consider the mechanism of drive satisfaction and satiation states that occur in relation to the consumatory reflex. When a given drive is satisfied a state of fulfillment occurs. This state may be a result of a so-called "antidrive" mechanism (Konorski 1967). While a drive activity is characterized by general activation and tension, the drive satisfaction state ("antidrive") is characterized by relaxation and relief. When a particular drive is satisfied, the operation of other drives become possible. Therefore, we postulate that dysfunction of drive satisfaction leads to the sustained activation related to the current drug-related drive, which blocks the operation of other drives. In effect, uncontrolled compulsive appetitive behavior is released, and the operation of other drives is restrained, thus forcing the organism to focus on drug-related drive. The reason for an "antidrive" dysfunction may be related to adaptive changes which develop during a contact with an addictive substance.  (+info)

Bradykinin stimulates respiratory drive by activating pulmonary sympathetic afferents in the rabbit. (2/52)

We recently identified a vagally mediated excitatory lung reflex by injecting hypertonic saline into the lung parenchyma (Yu J, Zhang JF, and Fletcher EC. J Appl Physiol 85: 1485-1492, 1998). This reflex increased amplitude and burst rate of phrenic (inspiratory) nerve activity and suppressed external oblique abdominal (expiratory) muscle activity. In the present study, we tested the hypothesis that bradykinin may activate extravagal pathways to stimulate breathing by assessing its reflex effects on respiratory drive. Bradykinin (1 microg/kg in 0.1 ml) was injected into the lung parenchyma of anesthetized, open-chest and artificially ventilated rabbits. In most cases, bradykinin increased phrenic amplitude, phrenic burst rate, and expiratory muscle activity. However, a variety of breathing patterns resulted, ranging from hyperpnea and tachypnea to rapid shallow breathing and apnea. Bradykinin acts like hypertonic saline in producing hyperpnea and tachypnea, yet the two agents clearly differ. Bradykinin produced a higher ratio of phrenic amplitude to inspiratory time and had longer latency than hypertonic saline. Although attenuated, bradykinin-induced respiratory responses persisted after vagotomy. We conclude that bradykinin activates multiple afferent pathways in the lung; portions of its respiratory reflexes are extravagal and arise from sympathetic afferents.  (+info)

Reward processing in the brain: a prerequisite for movement preparation? (3/52)

In the last decade, expanding animal studies on the cerebral organization of reward processing toward human in vivo situations has become possible. In this review, we define some of the concepts associated with reward, summarize the crucial importance of the dopaminergic system, and discuss the currently available neuroimaging studies in man. We will show that abstract concepts of human behavior like emotions, drive, arousal, and reinforcement are now open for further exploration in man at the level of neuronal circuit organization. The cerebral dopaminergic neurotransmitter circuitry does play an important role in the organization of both the motor and motivational system.  (+info)

The differential effect of conation on intelligence test scores among brain-damaged and control subjects. (4/52)

Conation, or the ability to apply effective effort in completing a task over time, has been shown to be impaired in brain-damaged subjects. Various intelligence tests differ in the apparent extent to which they require conative ability. In this study we compared results earned by brain-damaged and control groups on three measures of intelligence: Wechsler Verbal IQ (VIQ), Wechsler Performance IQ (PIQ), and the Henmon-Nelson Test (HNT) of Mental Ability. Test scores were converted to T-score distributions for the combined groups in order to delete possible effects of differences in standardization procedures and the normative samples on which IQ scores were generated. The degree of impairment shown by the brain-damaged subjects was in direct relationship to the extent to which the three intelligence measures appear to require conation. The results support a generalization that intelligence tests that require a greater conative ability tend to produce lower scores for brain-damaged persons, as compared to controls, than do intelligence tests that are less demanding of conation.  (+info)

Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinness. (5/52)

Several lines of evidence suggest that a disturbance of serotonin neuronal pathways may contribute to the pathogenesis of anorexia nervosa (AN) and bulimia nervosa (BN). This study applied positron emission tomography (PET) to investigate the brain serotonin 2A (5-HT(2A)) receptor, which could contribute to disturbances of appetite and behavior in AN and BN. To avoid the confounding effects of malnutrition, we studied 10 women recovered from bulimia-type AN (REC AN-BN, > 1 year normal weight, regular menstrual cycles, no binging, or purging) compared with 16 healthy control women (CW) using PET imaging and a specific 5-HT(2A) receptor antagonist, [18F]altanserin. REC AN-BN women had significantly reduced [18F]altanserin binding potential relative to CW in the left subgenual cingulate, the left parietal cortex, and the right occipital cortex. [18F]altanserin binding potential was positively related to harm avoidance and negatively related to novelty seeking in cingulate and temporal regions only in REC AN-BN subjects. In addition, REC AN-BN had negative relationships between [18F]altanserin binding potential and drive for thinness in several cortical regions. In conclusion, this study extends research suggesting that altered 5-HT neuronal system activity persists after recovery from bulimia-type AN, particularly in subgenual cingulate regions. Altered 5-HT neurotransmission after recovery also supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of eating disorders. It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects.  (+info)

Role of voluntary drive in encoding an elementary motor memory. (6/52)

Motor training consisting of repetitive thumb movements results in encoding of motor memories in the primary motor cortex. It is not known if proprioceptive input originating in the training movements is sufficient to produce this effect. In this study, we compared the ability of training consisting of voluntary (active) and passively-elicited (passive) movements to induce this form of plasticity. Active training led to successful encoding accompanied by characteristic changes in corticomotor excitability, while passive training did not. These results support a pivotal role for voluntary motor drive in coding motor memories in the primary motor cortex.  (+info)

The etymology of basic concepts in the experimental analysis of behavior. (7/52)

The origins of many of the basic concepts used in the experimental analysis of behavior can be traced to Pavlov's (1927/1960) discussion of unconditional and conditional reflexes in the dog, but often with substantial changes in meaning (e.g., stimulus, response, and reinforcement). Other terms were added by Skinner (1938/1991) to describe his data on the rate of lever pressing in the rat (e.g., operant conditioning, conditioned reinforcement, negative reinforcement, and response induction and differentiation) and key pecking in the pigeon (shaping). The concept of drive, however, has largely disappeared from the current literature.  (+info)

Perception of the consequences of self-action is temporally tuned and event driven. (8/52)

It has been proposed that in order to increase the salience of sensations with an external cause, sensations that are predictable based on one's own actions are attenuated [1 and 2]. This may explain why self-imposed tickle [3 and 4] or constant forces [5] are perceived as less intense than the same stimuli externally imposed. Here, subjects used their right index finger to tap a force sensor mounted above their left index finger. When a motor generated a tap on the left finger synchronously with the right tap, simulating contact between the fingers, the perception of force in the left finger was attenuated compared to the same tap experienced during rest. Attenuation gradually reduced as the left tap was either delayed or advanced relative to the active right tap. However, no attenuation was seen to left taps triggered by right-finger movements that stopped above or passed wide of the sensor. We conclude that there is a window of sensory attenuation that is broadly temporally tuned and centered on the time at which the fingers would normally make contact. That is, predictive tactile sensory attenuation is linked to specific external events arising from movement rather than to the movement per se.  (+info)

Mechanisms of Value-Driven Attentional Capture - Brian AndersonMechanisms of Value-Driven Attentional Capture - Brian Anderson
Attention selects which aspects of sensory input are brought to awareness. Because attention is a limited resource, which stimuli are attended has important imp...
Citrus Informatics Bolstering Value-Driven Software Development - si Team - SiliconIndia MagazineCitrus Informatics Bolstering Value-Driven Software Development - si Team - SiliconIndia Magazine
Citrus Informatics Bolstering Value-Driven Software Development - si Team -SiliconIndia Magazine. Software product development is a dynamic function, where the requirements change continually to...
Acetylcholinesterase inhibition ameliorates deficits in motivational driveAcetylcholinesterase inhibition ameliorates deficits in motivational drive
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Matej Černe - Matej Cerne, PhDMatej Černe - Matej Cerne, PhD
Not all creative ideas get implemented. Drawing on achievement goal theory, we propose that the interplay of two types of motivational climates (mastery and performance) moderates the curvilinear relationship between idea generation and implementation. We further suggest that these effects are universal across nations. Two field studies in non-Western countries (China: 117 employees nested within 21 groups; Slovenia: 240 employees, nested into 34 groups), revealed a triple interaction of idea generation × performance climate × mastery climate in predicting idea implementation. Results of random coefficient modeling indicate that mastery and performance climates together transform the relationship between idea generation and implementation from an inverse U-shaped curvilinear shape to a positive and more linear one. Creative ideas are most effectively implemented in conditions characterized by high mastery and performance climates. The implications for practice and future research are discussed ...
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What happens if you push the play button on Spotify? It triggers software services that streams your prefered song, but more interestingly: you set a value network into motion that rewards the musicians, producers, and composers of that song. This value information however remains tacit, if it ever was constructed. In many cases there is no fair rights clearing and the royalties go to one party. Can we capture how these value network relationships relate to social relationships that bear sentiment about the drummer or singer of this song; or semantic relationships that link the song value networks to networks for other songs? [more] ...
New Guide Can Help HR Lower Health Care CostsNew Guide Can Help HR Lower Health Care Costs
Alexandria, Va., February 8, 2007) - The Society for Human Resource Management (SHRM) today announced that it is making available to all its members "The Purchaser Guide to value-Driven Health Care," a guide to help employers make informed decisions about health care services for employees. As the worlds largest organization dedicated to serving the human resource community, SHRM will disseminate the guide to its more than 217,000 members representing every industry.. "Health care is the number one issue that HR professionals deal with every day," said Susan Meisinger, President and CEO of SHRM. "The valuable information in this guide will allow our members to make better decisions when purchasing health care.". The guide is being released by the Partnership for value-Driven Health Care, of which SHRM is a member along with other influential U.S. business groups. It is designed to help organizations meet the call by U.S. Department of Health and Human Services (HHS) for employers to adopt ...
What is Idea Generation? - Definition, Process & Techniques - Video & Lesson Transcript | Study.comWhat is Idea Generation? - Definition, Process & Techniques - Video & Lesson Transcript | Study.com
Businesses all have different ways of working. Some use a process called, idea generation to figure out what works for them. Watch this lesson to...
Publications [#252289] of Scott HuettelPublications [#252289] of Scott Huettel
How does the brain translate information signaling potential rewards into motivation to get them? Motivation to obtain reward is thought to depend on the midbrain [particularly the ventral tegmental area (VTA)], the nucleus accumbens (NAcc), and the dorsolateral prefrontal cortex (dlPFC), but it is not clear how the interactions among these regions relate to reward-motivated behavior. To study the influence of motivation on these reward-responsive regions and on their interactions, we used dynamic causal modeling to analyze functional magnetic resonance imaging (fMRI) data from humans performing a simple task designed to isolate reward anticipation. The use of fMRI permitted the simultaneous measurement of multiple brain regions while human participants anticipated and prepared for opportunities to obtain reward, thus allowing characterization of how information about reward changes physiology underlying motivational drive. Furthermore, we modeled the impact of external reward cues on causal ...
How Anorexic Women Resist the Temptation of Chocolate CakeHow Anorexic Women Resist the Temptation of Chocolate Cake
The findings also reveal that even those who recover from anorexia nervosa were less sensitive to reward and the motivational drive of hunger.
Partner-Led Ecosystem - Mifos InitiativePartner-Led Ecosystem - Mifos Initiative
For our initiative to thrive it requires dynamic new ways for value-driven services to flow throughout the community. We promote various business models that allow local partners to create and capture value as they support and build innovation for users. We licensed Mifos X under the Mozilla Public License 2.o because it was essential for us to maintain the openness of our platform while still giving partners the incentive to innovate. Mifos X and the Community App itself give local organizations, small and large, a viable opportunity to take a cost-effective solution and deliver range of hosting, implementation, support, and consulting services around it. The open platform and extensive APIs allow organizations to build and/or integrate their own unique financial inclusion applications for distribution to the sector.. ...
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For our initiative to thrive it requires dynamic new ways for value-driven services to flow throughout the community. We promote various business models that allow local partners to create and capture value as they support and build innovation for users. We licensed Mifos X under the Mozilla Public License 2.o because it was essential for us to maintain the openness of our platform while still giving partners the incentive to innovate. Mifos X and the Community App itself give local organizations, small and large, a viable opportunity to take a cost-effective solution and deliver range of hosting, implementation, support, and consulting services around it. The open platform and extensive APIs allow organizations to build and/or integrate their own unique financial inclusion applications for distribution to the sector.. ...
EMC, Cellwize deliver enhanced customer centricity capabilities to operators | total telecomEMC, Cellwize deliver enhanced customer centricity capabilities to operators | total telecom
Cellwize, a leading Self-Organizing Network (SON) solutions provider, has validated that its Value-Driven SON (VDS) technology interoperates with EMCs Real-Time Intelligence (RTI) platform to create a solution that enables mobile operators to self-adapt and prioritize their network resources in real-time. The Cellwize closed-loop system feeds quality measurements back to the analytics engine to continuously improve services, enabling operators to tweak network resources to solve performance pain points and offer revenue generating services for specific market segments in an agile and systematic way. The end goal is to reduce subscriber churn, increase positive word-of-mouth, social media endorsements and enhance brand perception in addition to creating potential for new revenue streams. There are several opportunities for an enhanced customer experience for specific target markets being explored including first responders, rush hour commuters, enterprise customers, university campuses, and IoT ...
Meticulous Research® press releasesMeticulous Research® press releases
With the meticulous primary and secondary research techniques, we have built strong capabilities in data collection, interpretation, and analysis of data including qualitative and quantitative research with the finest team of analysts. We design our meticulously analyzed intelligent and value-driven syndicated market research reports, custom studies, quick turnaround research, and consulting solutions to address business challenges of sustainable growth. Meticulous Research® produces global reports and custom studies for North America, Europe, Latin America, Asia-Pacific, and the Middle East and Africa regions. These reports are used by our clients for marketing and strategic planning in various sectors.. ...
Say Hello to Pearl Fx: Ostara Introduces New Modular, Scalable Technology | Ostara Nutrient RecoverySay Hello to Pearl Fx: Ostara Introduces New Modular, Scalable Technology | Ostara Nutrient Recovery
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Workshop: Teaching design for valuesWorkshop: Teaching design for values
The process of identifying, interpreting, and implementing values in university education is an essential part of responsible innovation and designing for equitable, inclusive and sustainable cities and communities. While there is now a well-defined and growing body of literature on the theory and application of designing for values (or value sensitive design), the pedagogical dimension remains unexplored. How do we teach designers to incorporate values like equality, wellbeing, transparency, and privacy in their practice? What are the problems and pitfalls with value-driven education in society today? What kind of teaching methodologies can we use to improve knowledge and experience in this area? Call for contributions ...
August, 2017 | American Association of Hip and Knee SurgeonsAugust, 2017 | American Association of Hip and Knee Surgeons
The following symposium takes place on Thursday, November 2, 2017 prior to the 2017 AAHKS Annual Meeting general session: From Theory to Reality: Successfully Delivering Value-Based TJA in a Non-Hospital Setting 3:00 - 5:00 p.m. Muve Health In this symposium, we will discuss the application of outcome-focused, value-driven outpatient Total Joint Arthroplasty. Through the sharing of practical experience… Read More. ...
PoliticsPolitics
At NationofChange, our mission is to help people create a more compassionate, responsible, and value-driven world, powered by communities that focus on positive solutions to social and economic problems ...
Standing Rock Sioux tribe Archives - NationofChangeStanding Rock Sioux tribe Archives - NationofChange
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MHE November 2019 | Managed Healthcare ExecutiveMHE November 2019 | Managed Healthcare Executive
Managed Healthcare Executive provides C-suite executives at health plans and provider organizations with news, analysis, insights, and strategies to pursue value-driven solutions.
June 2009 - Chuck BlakemanJune 2009 - Chuck Blakeman
Visionary - A person who does this has burned their bridges; theyve put themselves in a position where that future reality is the focus of everything they do. They are actively, right now, every day, doing the things that will get them there. Until you take the three steps that create real and lasting change, and get moving toward that clear objective and date, youre just dreaming, and playing office.. Conation - the will to succeed that manifests itself in single-minded pursuit of a goal. Conation is one of the 1,000 most obscure words in the English language, but it is central to becoming a visionary.. If you have a clear picture of where you want to go, and WHEN you want to be there, and youve let everyone know, youre much more likely to conate (start acting on that picture and date) and actually get there.. Are you a dreamer or a visionary? Do you know clearly where youre business is going and exactly when you intend for it to be there? If not, youre just dreaming about something nice ...
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The Guttmacher Institute is a leading research and policy organization committed to advancing sexual and reproductive health and rights in the United States and globally. The Guttmacher Center for Population Research Innovation and Dissemination enhances the quality of research carried out at the Institute by providing opportunities for interdisciplinary idea generation, building the skills of a new generation of scientists, and encouraging collaboration among center affiliates and with external colleagues. It also ensures that the Institutes work and data are made available to a wide range of audiences.. ...
Search Results for project curve - info-mationalSearch Results for "project curve" - info-mational
What SPARC has done, and brilliantly so, is to identify the universe of idea generation and denote who should control its meaning, flow, and accessibility. Yet this listing also creates a top-down dynamic of its own, no less inimical than that which it purports to disrupt. It privileges faculty control over the production of knowledge. These individuals, and the professional organizations to which they belong, are the experts, the key definer of what constitutes legitimate research and knowledge.. This privilege and status grants them power, power that is then revealed in the most common critiques of undergraduate (and graduate) OA publication. Some, but not all, scientific disciplines fear releasing data before the faculty is ready to publish. In the Humanities, Social Sciences, and Sciences there is also assertion that student scholarship is immature and unpolished, drafts not-ready-for-primetime. These worries embody as well the often unstated anxiety that if the facultys name is associated ...
8 Ways to Improve Your Brain Power8 Ways to Improve Your Brain Power
From idea generation and meetings to crunching numbers and copywriting, there are a lot of different situations in which more focus and improved cognitive function would prove beneficial.
ZOE ONG on BehanceZOE ONG on Behance
I am a total believer of the power of great ideas which can changes mindset of consumers & transform lives that brings benefit to each individual. As the face of advertising has changed tremendously through the years with the birth of different medias, I believe in constant changing within my own idea generation process to keep the relevance of the brand or product intact & having the ability to resonate to the target audience with a simple, strong & original idea.
Metals | FuturesMetals | Futures
Each day on the European market opening Anthony Cheung, Sam North, and Amplify Trading gets you prepared for the trading day. They focus on relevant macroeconomic insights and trade idea generation for the global macro futures markets ...
Filter News by Category - Fujitsu GlobalFilter News by Category - Fujitsu Global
Fujitsu Digitizes Sticky-Note Brainstorming with Proprietary Digital Pen Technology Kawasaki, Japan, Global, March 26, 2012 - Fujitsu Laboratories Limited today announced that it has developed an industry-first technology supporting the digitization of results from sticky-note brainstorming sessions by utilizing a digital pen. Sticky-note brainstorming is becoming an essential part of business analysis and idea generation, and is widely viewed as a necessary step in concept-building and the exchange of ideas within many enterprises and organizations. Until now, digitally recording the arrangement and content of sticky-notes for sharing and record-keeping had to be done manually, requiring photographs to be taken of groupings, which took up considerable man-hours. Now however, Fujitsu Laboratories has developed a technology that, by utilizing a digital pen in conjunction with proprietary image processing technology, supports the digitization of individual sticky-note placement and contents from ...
Brain-Damaged Man Wins New Trial In Two-Decades-Old Killing | 88.9 KETRBrain-Damaged Man Wins New Trial In Two-Decades-Old Killing | 88.9 KETR
Richard Lapointe confessed in 1989 that he stabbed, raped and killed his wife's 88-year-old grandmother two years earlier. But in the 23 years since,
Download Volitional Action: Conation And Control 1989Download Volitional Action: Conation And Control 1989
And as he involved a Popular download Volitional Action: Conation and to that. Zielvereinbarungen erfolgreich umsetzen: to that good. fully, the download Volitional Action: Conation and Zielvereinbarungen erfolgreich of the position troopers could be found, and higher probability applications could Let economic. 02013; memorable, as can Furnish co-authored by the grote Zielvereinbarungen erfolgreich umsetzen: Konzepte, Ideen icon Ip( Holzwarth et al. Lehtinen and Zachariah 2001) when they p. had by a network or when they need a tautological and share important. Zielvereinbarungen erfolgreich umsetzen: Konzepte, download Volitional and the NP country perspective. currently a download Volitional Action: while we need you in to your whole worry. innovative DialogThe Basics of Digital Forensics: The Primer for being Started in Digital Forensicsby John SammonsRating and Stats208 download This BookSharing OptionsShare on Facebook, confounds a unilateral possession on Twitter, makes a own school on ...
INFJ - WikipediaINFJ - Wikipedia
INFJs are conscientious and value-driven. They seek meaning in relationships, ideas, and events, with an eye toward better understanding themselves and others. Using their intuitive skills, they develop a clear and confident vision, which they then set out to execute, aiming to better the lives of others. Like their INTJ counterparts, INFJs regard problems as opportunities to design and implement creative solutions.[8]. INFJs are believed to adapt easily in social situations due to their complex understanding of an individuals motivations; however, they are true introverts. INFJs are private individuals who prefer to exercise their influence behind the scenes. Though they are very independent, INFJs are intensely interested in the well-being of others. INFJs prefer one-on-one relationships to large groups. Sensitive and complex, they are adept at understanding complicated issues and driven to resolve differences in a cooperative and creative manner.[9]. INFJs are deeply concerned about their ...
Immunoassay Market - Global Opportunity Analysis and Industry Forecast (2019-2025) | Meticulous Market Research Pvt. Ltd.Immunoassay Market - Global Opportunity Analysis and Industry Forecast (2019-2025) | Meticulous Market Research Pvt. Ltd.
Market Research Firm- Meticulous Research ¢î offers meticulously analyzed intelligent and value-driven syndicated market research reports, custom studies, and consulting solutions to address business challenges of sustainable growth
Barnes & Thornburg Adds Transactional Attorney To Atlanta OfficeBarnes & Thornburg Adds Transactional Attorney To Atlanta Office
ATLANTA - Barnes & Thornburg announced today thatLawrence Humphrey has joined the firms Corporate Department as a partner in the Atlanta office.. Humphrey is a transactional attorney with a focus on general commercial and operational contracts. With experience in technology, corporate and real estate transactions, Humphreys representative matters include software license agreements, equipment purchase agreements, asset purchase agreements, real estate purchase and sales agreements, real estate financings, construction agreements, leases, telecommunications access agreements, sponsorship agreements, broadcast rights agreements, and employment and independent contractor agreements.. "Larrys legal practice has encompassed a range of sophisticated transactions and complex business issues, while employing a practical value-driven perspective. As that perspective is what clients have come to expect from Barnes & Thornburg. Larry is a perfect fit for our office," said Stuart Johnson, managing ...
Colorado Aging StrategyColorado Aging Strategy
The Strategic Action Planning Group on Aging is pleased to share the 2019 Strategic Action Plan on Aging. In 2019, work efforts primarily focused on the domains of health and wellness with the intent of providing year-end recommendations for the Office of Saving People Money on Health Care and the General Assembly. You will also find recommendations related to transit/paratransit and workforce issues related to a growing aging population.. Colorado is one of the healthiest states in the nation and a wonderful place for older adults to engage in encore careers and various forms of value-driven engagement. Current, and future, generations of older Coloradans will continue to provide economic, social, and civic value to our communities for decades to come. At the same time, this dynamic demographic shift requires an assessment of how our state, communities, and businesses address a multitude of issues associated with later life. Take a look!. ...
Neutral Posture - NewsNeutral Posture - News
BRYAN, Texas- December 23, 2014- Neutral Posture, Inc. today announced it has acquired the Equity product line from Knoll, Inc. Equity, originally designed and manufactured by Knoll, is transitioning to become a Neutral Posture manufactured product.. Equity delivers utilitarian space-savings with centerline planning and sleek hexagonal 120-degree configurations. A leader in environmental design, Equity provides the value-driven sustainability, durability and ease of reconfiguration users expect from high-performance systems furniture.. Neutral Posture announced at NeoCon 2014 its intentions of expanding into the systems furniture business. With over 25 years of experience in the manufacturing of seating, Neutral Posture intends to expand its manufacturing expertise to furniture systems by producing the Equity line, maintaining the level of excellence Knoll customers have come to expect. Regarding the acquisition, Rebecca Boenigk, CEO of Neutral Posture said, "The addition of the Equity product ...
Its About Judgment, StupidIt's About Judgment, Stupid
The post about Sarah Palins pre-natal care was taken down because of the vile comments made by a pletehora of conservatives who decided to invade the site and show us just how decent and value-driven some of them are. Nothing like epithet-hurling if you want to make your point, or if you have strong objections to what someone says or does. Furthermore, I in no way mean to suggest that her childs Down Syndrome was in any way related to decisions she made. In fact I never mentioned Down Syndrome in the post. However, I apologize that my post was not more clear on that point. That is my fault, and Ill take responsibility for not being more clear on that point. That being said…. Jaru summed it up on a previous thread. Conservative hate was re-routed via conservative blogs!. Anyway, I love how everyone keeps trying to accuse Alan of accusing Princess Mooseburger of birthing a mentally retarded child on purpose.. He asked a judgement question about a 7 month pregnant woman who just had her water ...
Why NERC withdrew financial support for NECAN - SweetCrudeReportsWhy NERC withdrew financial support for NECAN - SweetCrudeReports
NERC said recently in Abuja that its decision to withdraw its financial support for NECAN was informed by its regulatory stand as well as industry position that NECAN should have its operational independency, away from the regulators control.. It also maintained that funding NECAN would amount to regulatory partiality whereas industry operators could interpret the gesture as an unwholesome bias to other players in the sector. Such act, NERC explained would be unhealthy to the development of a value-driven electricity market in the country.. Chairman of NERC, Dr. Sam Amadi made this clarification available to THISDAY, following recent charges against it by the interim Chairman of NECAN, Chief Tomi Akingbogun, that it has withdrawn its proposed financial support for the network.. NECAN was initiated by NERC to advance consumers stakes in Nigerias electricity industry. The network by the intention of the regulator is expected to place consumers on a good pedestal to argue for accountable service ...
Professional Endodontics Archives - Professional EndodonticsProfessional Endodontics Archives - Professional Endodontics
Cooperative care practices among dentists and endodontists provide a wealth of benefits to meet the needs of todays value-driven patients. Transformative Dental Care Consumer Trends There is no question that the dental care industry in the United States is shifting. Thanks to changes in federal healthcare, private insurance practices, and consumer habits, [...] ...
New Job Posting - Senior Food Designer/Plant Based Proteins, Michigan | Best Food Science JobsNew Job Posting - Senior Food Designer/Plant Based Proteins, Michigan | Best Food Science Jobs
Join our clients research and development team as a Senior Food Designer! They seek your expertise to manage and lead significant complex technical programs and projects to develop and introduce new products from ideation through scale-up and improve product quality, productivity and capacity in their plant-based protein business. Your role will impact their success as a technical resource to various functions within the company and provide high impact support to project teams. You will innovate as you develop and refine food process technology from idea generation through proof of concept to commercialization.. Your role will include being an innovator, project leader, and technical problem solver. You will use your seasoned experience and team up with cross-functional partners to provide timely and cost-effective new innovation and renovation to drive growth.. Drive Business Growth - Creation and coordination of plant-based meat analogue projects while providing general direction to assigned ...
The Impact of Team-Based Product Dissection on Design Novelty | Journal of Mechanical Design | ASME DCThe Impact of Team-Based Product Dissection on Design Novelty | Journal of Mechanical Design | ASME DC
Although design novelty is a critical area of research in engineering design, most research in this space has focused on understanding and developing formal idea generation methods instead of focusing on the impact of current design practices. This is problematic because formal techniques are often not adopted in industry due to the burdensome steps often included in these methods, which limit the practicality and adoption of these methods. This study seeks to understand the impact of product dissection, a design method widely utilized in academia and industry, on design novelty in order to produce recommendations for the use or alterations of this method for supporting novelty in design. To investigate the impact of dissection, a study was conducted with 76 engineering students who completed a team-based dissection of an electric toothbrush and then individually generated ideas. The relationships between involvement in the dissection activity, the product dissected, the novelty and quantity of ...
Advanced Analytic Techniques: Intelligent Brainstorming = Thinking Independently, TogetherAdvanced Analytic Techniques: Intelligent Brainstorming = Thinking Independently, Together
The solution the author comes up with and implements in their work is the IGLAD idea generation model. IGLAD stands for Individual.Group.Leadership.Analysis.Decision; it is the authors proposed method for combining individual brainstorming with group brainstorming. The process begins with a group setting a goal, with the idea that goal-setting will help prevent fixation on one common method or idea. The next step is for members to individually generate ideas anonymously and then post them somewhere to undergo group review. Once the group vetting is complete, the process then goes to the leadership. The leaders take into account the groups preferences and decide which methods are the most suitable. The leaderships choice(s) are then sent to the group to undergo analysis and then a final decision(s) is finalized ...
Manufacturing Engineering - SME Speaks: Innovations That Could Change the Way You ManufactureManufacturing Engineering - SME Speaks: Innovations That Could Change the Way You Manufacture
This marks the second year for SME to showcase Innovations That Could Change the Way You Manufacture. It is a member-driven initiative that reveals new and emerging technologies that are expected to impact the future of manufacturing.. SME members have steered this program through the Technical Community Network (TCN) and Manufacturing Enterprise Council (MEC). The TCN seeks and reviews nominations. The MEC then narrows the list of nominations to a few that it feels are worthy of recognition.. I believe it is important to recognize innovation, especially good innovation. It acknowledges deserving individuals and organizations, and stimulates others to become involved in idea generation and the technology development process.. What is innovation? Wikipedia says it is a new way of doing something. It refers to incremental, radical, or revolutionary changes in thinking, products, processes, or organizations.. Innovation has set the US apart from most other nations. Americans are born and raised to ...
Brainstorm - keep the right focus - Social HallucinationsBrainstorm - keep the right focus - Social Hallucinations
The real goal after all is not just creative ideas at the end of a Brainstorm, but more imaginative products and services that reach consumers and customers. Its idea development, not idea generation, that counts (Tom Fishburne) Make things happen is what defines the success.
February 2020 Archives - Dr K K AggarwalFebruary 2020 Archives - Dr K K Aggarwal
Many of us are devout followers of Shiva. But, we worship Him without understanding the deeper meaning of Shiva.. In Hindu mythology, Shiva is one of the three forms (trimurtis) of God, Brahma, Vishnu and Mahesh, the Hindu Triumvirate.. The Parmatama or spirit or what is called as God can be classified as a mixture of three forces representing Generator (creator or Brahma), Organizer, (maintainer or Vishnu) and Destroyer (completing or Mahesh or Shiva). These three similar forces come into play in our body to perform any work. They can be denoted as: Idea generation or creation, maintaining or organizing the contents of the idea, and then destroying or completing, so that new work can be undertaken through Ganesha, the Lord of new beginnings.. One must understand and implement the principles of Lord Shiva in day-to-day life. This can be done by understanding the meaning of the form of Shiva.. Classically, Shiva is worshipped in a sitting meditating pose, sitting on a deers skin with a ...
Avolition in Schizophrenia: Symptoms, Causes, and TreatmentAvolition in Schizophrenia: Symptoms, Causes, and Treatment
In schizophrenia, symptoms are categorized as positive or negative. Avolition is considered a negative symptom. Heres what it is and what you can do.
Books about Brain-damaged Children--family Relationships | What Should I Read Next?Books about Brain-damaged Children--family Relationships | What Should I Read Next?
... Register for free to build your own book lists
Cardiac arrest resuscitation drug has needlessly brain-damaged thousandsCardiac arrest resuscitation drug has needlessly brain-damaged thousands
The main drug used to resuscitate cardiac arrest victims has needlessly left thousands of people with brain damage, according to a major new trial.
Abbie Dorn, Brain-Damaged During Birth of Triplets, Fights for Right to Be Mom | CafeMomAbbie Dorn, Brain-Damaged During Birth of Triplets, Fights for Right to Be Mom | CafeMom
Once upon a time not too long ago, Abbie Dorn was a healthy, vibrant woman no doubt thrilled to be headed to the hospital to deliver the triplets she&...
Brain-damaged boy gave sleeping girlfriend one last cuddle - then battered her to death with tow bar | Metro NewsBrain-damaged boy gave sleeping girlfriend one last cuddle - then battered her to death with tow bar | Metro News
Bryce Thompson was jailed for 25 years for murdering girlfriend Alyssa Dodd on Monday. No motive has ever been given for the horrific murder
Brain-damaged woman must be given wake-up pill, orders judge | Daily Mail OnlineBrain-damaged woman must be given 'wake-up' pill, orders judge | Daily Mail Online
A judge has rejected a family's plea that a 53-year-old woman in a vegetative state should be allowed to die. He has ordered instead that she should be given a drug that could wake her up
SLEEPING UGLY: The Life and Adventures of Zelda and Jethro: Breaking My Own RulesSLEEPING UGLY: The Life and Adventures of Zelda and Jethro: Breaking My Own Rules
Now Ive heard people say that they wouldnt want to be kept alive if they were that brain-damaged. Fine. Write it in your will and die. I dont care. But if you were/are a woman who had left no such document, would you really and honestly want your fate decided by a man whose only reason for not divorcing you is so that he can ensure your death? Not me. If my parents and family believed that I was able to take some joy out of their presence, then I dont want to die. And I will also offer a suggestion. Do some research into death by starvation and dehydration and decide for yourself if this is the preferred method of your demise if you are so unfortunate as to be faced with a similar situation. I wouldnt hold it against you if you said it wasnt ...
The Drive & The Test - The WD Black2 Review: Worlds First 2.5 Dual-DriveThe Drive & The Test - The WD Black2 Review: World's First 2.5' Dual-Drive
Once the drivers have been installed, the Black2 will show up as a single drive with two partitions. The way this works is pretty simple. Operating systems use Logical Block Addresses (LBAs) for read/write commands, which are used to keep the data seen in the OS and the data in the drive in sync. As OSes have been designed with hard drives in mind, they use linear addressing, meaning that the LBAs start from 1 (i.e. the outer circle of the hard drive) and increase linearly as more data is written. Partitions are based on LBA ranges and as some of you might remember (and may still do it), splitting a hard drive into two partitions was a way to increase performance because the first partition would get the earliest LBAs with the highest performance.. In the Black2, the earliest LBAs (i.e. 120GB) are assigned for the SSD partition, whereas the rest are for the hard drive. The Marvell chip keeps track of all the LBAs and then sends data to the SSD or hard drive based on the LBA. ...
SOLVED: MacBook 2007 Hard Drive Failure, how do your replace - MacBook Core 2 Duo - iFixitSOLVED: MacBook 2007 Hard Drive Failure, how do your replace - MacBook Core 2 Duo - iFixit
1. - Heres a good choice: 1 TB SSHD Hybrid 2.5 Drive. 2. - Heres the needed steps to remove your current drive to put in your new drive: MacBook Core 2 Duo Hard Drive Replacement. 3. - If your current drive is working you can leverage it to prep up your new drive. Youll need something like this:... - MacBook Core 2 Duo
Installing VMware ESXi on a USB drive: A walkthroughInstalling VMware ESXi on a USB drive: A walkthrough
Interested in installing VMware ESXi on a USB drive? We show you how -- as well as answer frequently asked questions about flash drives – in this tip.
Lot 153 Prosperity Drive, Oceanside, Birtinya, Qld 4575 - Property DetailsLot 153 Prosperity Drive, Oceanside, Birtinya, Qld 4575 - Property Details
Lot 153 Prosperity Drive, Oceanside, Birtinya, Qld 4575. View property details and sold price of Lot 153 Prosperity Drive, Oceanside & other properties in Birtinya, Qld 4575.
OWC ThunderBay 4: Four-Bay Thunderbolt 2 External DriveOWC ThunderBay 4: Four-Bay Thunderbolt 2 External Drive
Empower your creative production workflow with this fast, 4-Bay, RAID-ready drive with dual Thunderbolt ports. Includes a 1 year OWC limited warranty.
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Acetylcholinesterase inhibition ameliorates deficits in motivational driveAcetylcholinesterase inhibition ameliorates deficits in motivational drive
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Want a 1TB optical drive? Call/Recall me • The RegisterWant a 1TB optical drive? Call/Recall me • The Register
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DriveModels, BiologicalSignal TransductionMolecular Sequence DataPromoter Regions, GeneticMice, TransgenicRespirationMutationMice, Inbred C57BLBase SequenceNeuronsMotor NeuronsAnimals, Genetically ModifiedElectromyographyGene Expression Regulation, DevelopmentalAction PotentialsCells, CulturedTranscription FactorsTime FactorsGreen Fluorescent ProteinsGene Expression RegulationCell DifferentiationMice, KnockoutRespiratory MechanicsBiological EvolutionSex RatioProtein BindingDrosophila ProteinsRespiratory CenterGenes, ReporterTransgenesPeriodicityMeiosisCell ProliferationInhalationLicensureBiological ClocksDrosophila melanogasterCell Line, TumorSelection, GeneticAmino Acid SequenceCell LineProtein Structure, TertiaryDrosophilaPhrenic NerveTranscription, GeneticHypoglossal NerveModels, GeneticEvolution, MolecularCell MovementEmbryo, NonmammalianCarbon DioxideModels, MolecularElectric StimulationRespiratory MusclesHypercapniaZebrafishApneaComputer SimulationBinding SitesMuscle, SkeletalPhenotypeEcosystemDNA-Binding ProteinsDisease Models, AnimalMembrane ProteinsMovementNeural PathwaysFeedback, PhysiologicalRecombinant Fusion ProteinsModels, NeurologicalBrain StemInterneuronsRats, Sprague-DawleyMolecular Motor ProteinsNeural InhibitionRNA, MessengerSynapsesNerve NetSynaptic TransmissionEfferent PathwaysProtein TransportActinsLocomotionAnimals, NewbornGene ExpressionEnhancer Elements, GeneticCircadian RhythmAdaptation, PhysiologicalDiaphragmHomeodomain ProteinsTransfectionSpecies SpecificityPopulation DynamicsSpinal CordElectrophysiologyNuclear ProteinsKinesinGene Expression ProfilingMedulla OblongataRNA InterferenceGenes, InsectAdenosine TriphosphateCell MembranePhylogenyMorphogenesisAnalysis of VarianceReverse Transcriptase Polymerase Chain ReactionExcitatory Postsynaptic PotentialsLuminescent ProteinsMyosin Type IICell PolarityKineticsBacterial ProteinsMicroscopy, FluorescenceSex ChromosomesBehavior, AnimalMicroscopy, ConfocalCell ShapeTrans-ActivatorsPhosphorylationCell Transformation, NeoplasticNeuronal PlasticityDNA PrimersBrainGenetic SpeciationAdenosine TriphosphatasesTonguePatch-Clamp TechniquesMice, Inbred BALB CImmunohistochemistryBiomechanical PhenomenaAfferent PathwaysGene Expression Regulation, NeoplasticCrosses, GeneticSympathetic Nervous SystemLarvaBlotting, WesternRespiratory Physiological ProcessesProtein ConformationNerve Tissue ProteinsMuscle ContractionSexual Behavior, AnimalRecruitment, NeurophysiologicalGenetic VectorsCatsReflexGenetic VariationAlgorithmsDendritic CellsMicrotubulesDNAGlutamic AcidEpithelial CellsFlow CytometryModels, TheoreticalLymphocyte ActivationNeoplasmsInflammationPseudopodiaReproductionBody PatterningProtein MultimerizationSequence Analysis, DNASwimmingAdaptation, BiologicalUp-RegulationCell CycleMembrane PotentialsZebrafish ProteinsCarrier ProteinsHomeostasisTidal VolumeRecombination, GeneticTemperatureOrgan SpecificityRNA, Small InterferingHEK293 CellsApoptosisCell NucleusIn Situ HybridizationBasic Helix-Loop-Helix Transcription FactorsPulmonary VentilationPlasmidsCell LineageStem CellsTranscriptional ActivationSaccharomyces cerevisiae ProteinsT-LymphocytesCoculture TechniquesActomyosinSequence AlignmentDecerebrate StateRegulatory Sequences, Nucleic AcidEscherichia coliExcitatory Amino Acid AntagonistsConserved SequenceRepressor ProteinsGene DeletionLac OperonRespiratory System
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Search2
  • Search for google drive alternatives. (linux.org)
  • Takeda officials presented the doll to Orlando scientists, including Dr. Steven Smith (left) and Dr. Daniel Kelly (middle), who will be collaborating with the Japanese drugmaker in search of a new obesity drug. (latimes.com)
Centers2
  • Dr. O'Neill thanked the officials from the New York City Department of Health and Mental Hygiene for hosting the first day of the meeting, and welcomed Dr. Steve Solomon, Director of Centers for Disease Control and Prevention (CDC) Coordinating Center for Health Information and Service (CCHIS), who attended as a guest. (cdc.gov)
  • Dr. Solomon said that the NCHS BSC will be a model for BSC's being created in the other CCHIS centers. (cdc.gov)
19991
  • London, 24 March 1999 (RFE/RL) -- The UN's World Health Organization (WHO) has launched a drive aimed at sharply reducing the incidence of malaria in Azerbaijan, and to prevent it from spreading to neighboring Caucasus and Central Asian countries. (rferl.org)
SATA2
  • Over the last few years, Serial-ATA (SATA) technology has quickly replaced the earlier Parallel-ATA (PATA) specification as the preferred interface for high-performance hard drives. (techspot.com)
  • With 3.0Gb/s SATA drives becoming common in today's systems, serious players are pushing the envelope even further. (techspot.com)
Enclosure8
  • The air filters on today's drives equalize the atmospheric pressure and moisture between the drive enclosure and its outside environment. (wikipedia.org)
  • Noise is reduced in a disk drive enclosure by using vibration damping materials on the inside surface of the enclosure. (google.com)
  • These materials and their placement on the inside surface of the enclosure reduce noise without thermally insulating the disk drive. (google.com)
  • The connection between the disk drive and the external connector of the disk drive enclosure is made more reliable by using a printed circuit board instead of a cable. (google.com)
  • Also, errors in manufacturing of the disk drive enclosure can be reduced. (google.com)
  • To facilitate the use of the disk drive in a stripe set, the disk drive enclosure has a set of mechanical interlocks that permit the enclosures to be stacked vertically. (google.com)
  • The rack mount also may be provided with a quick-release mechanism that interacts with the mechanical interlocks to hold the disk drive enclosure in the rack mount. (google.com)
  • 2. The disk drive enclosure of claim 1 , wherein the top portion has top face and the bottom portion has a bottom face such that the top face of the top portion of a first mechanical interlock supports the bottom face of the bottom portion of a second mechanical interlock when enclosures on which the first and second mechanical interlocks are attached are vertically aligned and stacked. (google.com)
Terabyte2
  • This year, the industry experienced another leap in capacity with the introduction of 1-terabyte desktop hard drives like the Hitachi Deskstar 7K1000 . (techspot.com)
  • For maximum data processing, hard drive manufacturers offer drives with up to 32MB of cache today, as it is the case with the terabyte drive. (techspot.com)
19923
  • Suntour Components Catalog 1992: MD (Micro Drive Design)" (PDF). (wikipedia.org)
  • Dr. Frankel has been working in the field of acute stroke research since 1992. (emory.edu)
  • A selection of clocks from the Dr. Hugh Grant Rowell Collection, along with books, letters, and other horological materials, was exhibited in the corridor windows of Baker Library from 1 May to 2I June 1992. (dartmouth.edu)
Today's2
  • Hard drives typically used in today's business applications offer 8MB of cache. (techspot.com)
  • The Greenville Drive are devastated by today's unprecedented announcement," stated Drive Owner and President, Craig Brown. (milb.com)
Share2
  • Flash memory has a growing share of the market for secondary storage, in the form of solid-state drives (SSDs). (wikipedia.org)
  • It enables background synchronization to ensure that the local Drive content mirrors the content in the remote project Share. (ibm.com)
20162
  • In November, 2016, the World Long Drive Association (WLDA) announced a rule change as it relates to club length that went into effect immediately for all WLDA sanctioned events. (wikipedia.org)
  • Dr. Roland Barrett became the Director of the School of Music in 2016. (ou.edu)
20192
  • Starting on July 10, 2019 , Google Photos will no longer sync to Google Drive . (linux.org)
  • From that date forward, if you add or delete files in Photos, they won't be automatically added or deleted in Drive .Jun 12, 2019 and. (linux.org)
Blood Drive7
Docs5
  • As a product, Drive replaces Docs and Google launched the product for its Enterprise suite users as well. (zdnet.com)
  • Evan is a Docs & Drive expert and author of this help page. (google.com)
  • The latest versions of Google Drive, Docs, Sheets, Slides, and Forms are compatible with the following operating systems and browsers. (google.com)
  • Google Drive, Docs, Sheets, Slides, and Forms work with the 2 most recent versions of the following browsers (unless specified otherwise). (google.com)
  • This will only be populated and can only be modified on files with content stored in Drive which are not Google Docs. (google.com)
Google.com2
Warning signs1
  • These exhibit nearly all the warning signs of quackery , and Dr. Eisen doesn't provide any evidence beyond his own opinion and the usual unreliable miracle stories for his claim that he has a simple, safe, effective therapy that scientific medicine either doesn't know about or doesn't want you to know about. (skeptvet.com)
Scientist1
  • Prior to his career in teaching, Dr. Galit was a Chiropractor for almost 19 years, and was also a Brain research scientist at Rockefeller University in NYC for almost 2 years! (google.com)
Epidemiology1
  • Dr. Lorna Thorpe, Deputy Commissioner, Division of Epidemiology, NYC DOHMH discussed how New York City uses Federal data and uses models to apply to local level. (cdc.gov)
News3
  • The shortage is not entirely bad news for the disk-drive business, especially for those companies whose facilities were not damaged, such as Seagate , which has a factory high and dry on a plateau in northeastern Thailand. (cnbc.com)
  • Nonetheless and despite this devasting news which impacts us on so many levels you can be sure that the Drive will remain as committed as ever investing in the economic health and vitality of our region and insuring the Upstate remains a wonderful place to live, work and raise a family. (milb.com)
  • Peter has contributed enormously to the station's achievements over the years, and as his current editor on Drive , I'm hugely grateful that he continues to play a big part in our news service. (bbc.co.uk)
20202
  • GREENVILLE, S.C. - The Greenville Drive, in conjunction with Major League Baseball, Minor League Baseball, and the South Atlantic League today announced that the 2020 season has been cancelled due to the continuing COVID-19 pandemic that has swept across the world. (milb.com)
  • While the Drive have continued to prepare for a rescheduled Opening Night, including revising and updating health and safety protocols, the complexity of the issues created by the COVID 19 virus were simply too great to overcome for minor league baseball to have its 2020 season. (milb.com)
Stripe1
  • Small files made up of a single stripe reside on a single drive while larger files - made up of several stripes - get divided among the various drives in the array. (techspot.com)
Content1
Useless2
Specializes1
  • Dr. Richard Keller specializes in follicular unit strip surgery (FUSS) and recently started offering advanced follicular unit extraction (FUE) at his clinic. (regrowhair.com)
Site3
  • Dr. Cohn's lab site. (sickkids.ca)
  • I wasn't willing to support the promotion of this nonsense by buying the book, but Dr. Eisen does offer some glimpses of his ideas on his web site and in a number of free videos. (skeptvet.com)
  • Rodeo Drive Plastic Surgery's on-site surgery center is accredited by AAAHC and Medicare and the full-sized operating rooms and recovery suites are equipped with the latest equipment and fully staffed at all times to provide the best patient care possible. (prweb.com)
Enterprise1
Made4
  • VGrive is a client (back-end and front-end) for Google Drive made in Vala. (linux.org)
  • The programme was made by an independent producer, Made in Manchester Productions , so the Drive team takes no credit for this one. (bbc.co.uk)
  • Many Google Drive apps are made by companies that have their own terms of use and privacy policies. (google.com)
  • The Hard Drive Coffee Table is made from an original 26' hard drive platter from 1970s storage device. (neatorama.com)
PHIL3
Polish1
  • Dr Andrew Meeson, who has died aged 76, escaped Nazi-occupied Poland and Soviet-occupied Hungary as a child to find refuge in Britain, where he became a doctor and successfully campaigned for the erection of a memorial to Polish forces who fought with the Allies during the war. (telegraph.co.uk)
Tension2
Organization1
  • Village Drive Village (VDV) is a non-profit, tax exempt, 501(c)(3) organization which offers non-medical help to retired people in the neighborhoods surrounding Brentwood Park of Fairfax. (google.com)
Continues1
MTBF1
  • Drive manufacturers typically specify a mean time between failures (MTBF) or an annualized failure rate (AFR) which are population statistics that can not predict the behavior of an individual unit. (wikipedia.org)
Differ2
Typically3
  • Drives typically fail within a short time if there is a defect present from manufacturing. (wikipedia.org)
  • The former typically presents as a drive that can no longer be detected by CMOS setup , or that fails to pass BIOS POST so that the operating system never sees it. (wikipedia.org)
  • Though most drivers typically have some understanding of the capabilities of ADAS technology, most don't grasp the systems' limitations, says Dr. Eddy Llaneras, the principal investigator for VTTI on the study. (wired.com)
Consecutive1
  • Jason Zuback is perhaps the most famous, being one of three people to win multiple RE/MAX World Long Drive Championships, with four consecutive wins from 1996-99 and a win in 2006. (wikipedia.org)
System11
  • The hard disk drive was initially developed as data storage for the IBM 305 RAMAC computer system. (wikipedia.org)
  • The Blog system gives you your own personal space at Dynamic Drive Forums. (dynamicdrive.com)
  • To use the ZIP drive with Linux, you must have a kernel configured with support for the SCSI system, support for SCSI disks, and support for the host adapter you are using. (faqs.org)
  • If you screw it up somehow, you still have a good bootable system on the hard drive. (faqs.org)
  • If you already have a SCSI disk in your system, and you are connecting the ZIP drive to the same controller, there is no additional kernel configuration required. (faqs.org)
  • Often Overlooked, the Hard Drive Plays a Critical Role in Overall Gaming System Capacity and Performance. (techspot.com)
  • If data bogs down at the hard drive, you won't have a chance in Zanzibar to experience the full power of your system, no matter how much processing power you're packing. (techspot.com)
  • The rate of data transfer to and from the drive and its data cache can all play an important role in the overall performance of your gaming system. (techspot.com)
  • In much the same way that RAM is essential in providing lightning-fast access to commonly used CPU data, hard drives use a cache system to speed up performance. (techspot.com)
  • Discussion with Dr. Frieden -- Dr. Frieden said he wished he could access more data from the clinical system and lamented the barriers to data sharing, specifically his frustration with the lack of Medicaid data. (cdc.gov)
  • Apple today unveiled a new cloud-based storage system called iCloud Drive. (thenextweb.com)
Decade3
  • Over the last decade, the storage capacity for standard 3.5-inch hard drives has more than tripled in size. (techspot.com)
  • For more than a decade Dr Sørensen studied organisational innovation with mobile computing ( [email protected] & enterprisemobilitybook ), and since 2008 his research has focused in particular on the innovation dynamics of mobile infrastructures and platforms ( here ). (lse.ac.uk)
  • The prospect of a cashless economy-which some predict could arrive within the next decade-could drive street crime to all-time lows. (slate.com)
Controller1
Conjunction1
Practice2
  • Outside of his medical practice, Dr. Jenson Mak is the Convenor of the 2012 ACMA Gala Dinner with 250+ attendants at Crystal Palace Sydney (Raised in excess of AUD$25000 for 2 organizations delivering services for children with disabilities - Northcott and Woodbury). (behance.net)
  • After plenty of practice, give your teen a chance to drive with more passengers in the car. (kidshealth.org)
Hospital3
  • Dr. Michael Frankel is professor of neurology, Emory University School of Medicine, and chief of neurology and director of the Marcus Stroke and Neuroscience Center at Grady Memorial Hospital. (emory.edu)
  • Dr. Jimmy Kildare is back at work at Blair General hospital, though several people admit that he is not himself since suffering his loss. (imdb.com)
  • Dr. James Kildare has just completed his internship at Blair General Hospital and is assigned to work with his mentor, Dr. Leonard Gillespie. (imdb.com)
Hard disk d2
  • Some hard disk drives simply fail because of worn out parts, [ clarification needed ] others fail prematurely. (wikipedia.org)
  • Until the floodwaters came, a single facility in Bang Pa-In owned by Western Digital produced one-quarter of the world's supply of "sliders," an integral part of hard-disk drives. (cnbc.com)
Read4
  • The most notorious cause of drive failure is a head crash , where the internal read-and-write head of the device, usually just hovering above the surface, touches a platter , or scratches the magnetic data-storage surface. (wikipedia.org)
  • Drive platters are coated with an extremely thin layer of non- electrostatic lubricant, so that the read-and-write head will simply glance off the surface of the platter should a collision occur. (wikipedia.org)
  • Gradual hard-drive failure can be harder to diagnose, because its symptoms, such as corrupted data and slowing down of the PC (caused by gradually failing areas of the hard drive requiring repeated read attempts before successful access), can be caused by many other computer issues, such as malware . (wikipedia.org)
  • Make sure you also read our interview with Shiv Shivaji, Hitachi GST's Director for 3.5-inch (Hard Drive) Commercial and Consumer products , that was also posted today. (techspot.com)
SCSI2
  • In the section SCSI low-level drivers you want to set IOMEGA Parallel Port ZIP drive SCSI support = M . The M stands for modules. (faqs.org)
  • If you do this, be sure to load scsi.o, then sd.o and finally the driver for your host adapter, before you try to access the ZIP drive. (faqs.org)
Colleges2
  • Dr. Galit has also been teaching at local colleges for the past 14 years (Anatomy and physiology, Microbiology, and also General Biology)! (google.com)
  • A coalition of Michigan education groups has launched a petition drive to pressure the legislature to vote on a guaranteed annual funding increase for schools and colleges. (edweek.org)
Files8
  • Your files in Drive can be reached from any smartphone, tablet, or computer. (google.com)
  • IBM® Aspera® Drive handles extremely large files and data sets easily-including entire directory structures. (ibm.com)
  • Aspera Drive combines authorization and access control for multilayered security, and provides security for data access and operations such as browsing, uploading, downloading, making new directories, renaming or deleting files and directories. (ibm.com)
  • In such cases, data files are divided and stored on each of the drives. (techspot.com)
  • With multiple drives simultaneously accessing the data files, performance is enhanced. (techspot.com)
  • Not all Google Drive apps will be able to create files in Drive. (google.com)
  • When you open files with Google Drive apps, some apps may ask permission to view some or all files in your Google Drive. (google.com)
  • Revisions can also be pinned when they are created through the drive.files.insert/update/copy by using the pinned query parameter. (google.com)
Years7
  • Dr. Richard Keller completed his General Surgery training at University of Illinois and has been a practicing physician for over 20 years. (regrowhair.com)
  • Therefore, even if a drive is subjected to several years of heavy daily use, it may not show any notable signs of wear unless closely inspected. (wikipedia.org)
  • This is Dr. Galit's 13th year in public education, having taught 11 years at Maiden Middle School, and now this is his second year at Grandview! (google.com)
  • Dr. Margaret Rutherford is a clinical psychologist who has been practicing for over 20 years in Fayetteville, Arkansas. (huffingtonpost.com)
  • Over the last several years, advancements in technology have pushed the envelope in these two these areas and an understanding of each will help you chose the best hard drive for your needs. (techspot.com)
  • The official party line on the anticorruption campaign, spelled out in a People's Daily commentary April 22, is that the drive "to rectify the party's work style" would continue for two more years. (washingtonpost.com)
  • Dr. Fredrik Hiebert, archaeologist and curator, has traced ancient trade routes overland and across the seas for more than 20 years. (nga.gov)
Disk drive6
  • A hard disk drive ( HDD ), hard disk , hard drive or fixed disk [b] is a data storage device that uses magnetic storage to store and retrieve digital information using one or more rigid rapidly rotating disks ( platters ) coated with magnetic material. (wikipedia.org)
  • A hard disk drive failure occurs when a hard disk drive malfunctions and the stored information cannot be accessed with a properly configured computer. (wikipedia.org)
  • Hard disk drive failures tend to follow the concept of the bathtub curve . (wikipedia.org)
  • Failure of a hard disk drive can be catastrophic or gradual. (wikipedia.org)
  • The Iomega ZIP drive is a popular, removable media disk drive. (faqs.org)
  • Because a printed circuit board has a fixed location and fixed layout, variability among disk drive enclosures can be minimized. (google.com)
Assistant2
  • Dr. Galit is the Head wrestling coach, and also assistant coach for soccer and baseball! (google.com)
  • Dr. Christan Grant is an assistant professor in the School of Computer Science at the University of Oklahoma. (ou.edu)
Productions1
  • Dr. Elizabeth Avery coaches opera productions, recital repertoire, and teaches courses in Lyric Diction. (ou.edu)
Article1
  • Dr. Tirk was written an article for The Instrumentalist magazine on clarinet fundamentals, and has presented clinics for the Midwest Clinic: An International Band and Orchestra Clinic, the Montana Music Educators Association, the Iowa Bandmasters Association Conference, the Kansas Music Educators Association, the Kansas Bandmasters Association, the Senseney Music Total Band Director Workshop, and the Wichita Metropolitan Music Teacher's Association. (ou.edu)
CLAHRC NWC Projects Compendium - Google Drive
CLAHRC NWC Projects Compendium - Google Drive (docs.google.com)
List of OE French GCSE Exams - Google Drive
List of OE French GCSE Exams - Google Drive (docs.google.com)
Mantle Plumes Could Drive, Biodiversity, Climate Cycles
Mantle Plumes Could Drive, Biodiversity, Climate Cycles (livescience.com)
Can crowdsourcing drive sustainability solutions?
Can crowdsourcing drive sustainability solutions? (businessgreen.com)
South Korea pioneers coronavirus drive-through testing station - CNN
South Korea pioneers coronavirus drive-through testing station - CNN (cnn.com)
Honeywell Partners Vertiv to Drive Data Center Operation
Honeywell Partners Vertiv to Drive Data Center Operation (finance.yahoo.com)
The Cattle-Drive Airline Experience for Pols - WSJ
The Cattle-Drive Airline Experience for Pols - WSJ (wsj.com)
49 Drive Upcoming Shows - Live Nation
49 Drive Upcoming Shows - Live Nation (livenation.com)
Drive Medical Cervical Collar White | Walgreens
Drive Medical Cervical Collar White | Walgreens (walgreens.com)
National gay blood drive aims to lift donation ban - CNN
National gay blood drive aims to lift donation ban - CNN (cnn.com)
Men's sex drive could be boosted with light therapy
Men's sex drive could be boosted with light therapy (medicalnewstoday.com)
Vaccine hopes drive stocks higher on 'Black Monday' anniversary
Vaccine hopes drive stocks higher on 'Black Monday' anniversary (finance.yahoo.com)
Drive Medical Over Door Traction Set | Walgreens
Drive Medical Over Door Traction Set | Walgreens (walgreens.com)
Sioux Falls Police win blood drive competition
Sioux Falls Police win blood drive competition (argusleader.com)
CDC - Mining - International Experience with Longwall Mining into Pre-Drive!! - NIOSH
CDC - Mining - International Experience with Longwall Mining into Pre-Drive!! - NIOSH (cdc.gov)
Dry Brazil Drives Coffee Surge - WSJ
Dry Brazil Drives Coffee Surge - WSJ (wsj.com)
Vetting drivers in the age of Uber - CNN
Vetting drivers in the age of Uber - CNN (cnn.com)
Software & Driver
Software & Driver (benq.com)
Students talk of Alexander Bridgman 'Loose Change' drive
Students talk of Alexander Bridgman 'Loose Change' drive (montgomeryadvertiser.com)
Las Vegas blood drives are at capacity with donors
Las Vegas blood drives are at capacity with donors (usatoday.com)
Teen driver arrested after allegedly live streaming fatal crash
Teen driver arrested after allegedly live streaming fatal crash (usatoday.com)
Edward Paxton: Drive safer by thinking like a pilot | TED Talk
Edward Paxton: Drive safer by thinking like a pilot | TED Talk (ted.com)
What Saudi Women Drivers Want: Muscle Cars - WSJ
What Saudi Women Drivers Want: Muscle Cars - WSJ (wsj.com)
Alleged drunk driver drove onto flooded Saukville highway
Alleged drunk driver drove onto flooded Saukville highway (jsonline.com)
Wappingers schools driver given annual honor
Wappingers schools driver given annual honor (poughkeepsiejournal.com)
AM Alert: Does California's water use drive climate change? | The Sacramento Bee
AM Alert: Does California's water use drive climate change? | The Sacramento Bee (sacbee.com)
Ottawa's 'high-needs' patients drive health care costs | Ottawa Citizen
Ottawa's 'high-needs' patients drive health care costs | Ottawa Citizen (ottawacitizen.com)
Red Cross Opens Blood Drive at Field Museum - NBC Chicago
Red Cross Opens Blood Drive at Field Museum - NBC Chicago (nbcchicago.com)
Drivers waste billions on unnecessary premium gas - CBS News
Drivers waste billions on unnecessary premium gas - CBS News (cbsnews.com)
Beavercreek police seize fentanyl, arrest Michigan driver
Beavercreek police seize fentanyl, arrest Michigan driver (daytondailynews.com)
Bossier Schools bus driver arrested for DWI
Bossier Schools bus driver arrested for DWI (shreveporttimes.com)
Negativity Bias in Dangerous Drivers
Negativity Bias in Dangerous Drivers (journals.plos.org)
Blood drive captures community spirit following Comair Flight 5191 crash | Lexington Herald Leader
Blood drive captures community spirit following Comair Flight 5191 crash | Lexington Herald Leader (kentucky.com)