Drive. Medical search

A state of internal activity of an organism that is a necessary condition before a given stimulus will elicit a class of responses; e.g., a certain level of hunger (drive) must be present before food will elicit an eating response.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

Neurons which activate MUSCLE CELLS.

ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.

Recording of the changes in electric potential of muscle by means of surface or needle electrodes.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

Elements of limited time intervals, contributing to particular results or situations.

Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.

The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.

The number of males per 100 females.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.

Part of the brain located in the MEDULLA OBLONGATA and PONS. It receives neural, chemical and hormonal signals, and controls the rate and depth of respiratory movements of the DIAPHRAGM and other respiratory muscles.

Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.

Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.

The tendency of a phenomenon to recur at regular intervals; in biological systems, the recurrence of certain activities (including hormonal, cellular, neural) may be annual, seasonal, monthly, daily, or more frequently (ultradian).

A type of CELL NUCLEUS division, occurring during maturation of the GERM CELLS. Two successive cell nucleus divisions following a single chromosome duplication (S PHASE) result in daughter cells with half the number of CHROMOSOMES as the parent cells.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

The act of BREATHING in.

The legal authority or formal permission from authorities to carry on certain activities which by law or regulation require such permission. It may be applied to licensure of institutions as well as individuals.

The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.

A species of fruit fly much used in genetics because of the large size of its chromosomes.

A cell line derived from cultured tumor cells.

Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Established cell cultures that have the potential to propagate indefinitely.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.

The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

The 12th cranial nerve. The hypoglossal nerve originates in the hypoglossal nucleus of the medulla and supplies motor innervation to all of the muscles of the tongue except the palatoglossus (which is supplied by the vagus). This nerve also contains proprioceptive afferents from the tongue muscles.

Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.

The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.

The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.

A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Use of electric potential or currents to elicit biological responses.

These include the muscles of the DIAPHRAGM and the INTERCOSTAL MUSCLES.

A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.

An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.

A transient absence of spontaneous respiration.

Computer-based representation of physical systems and phenomena such as chemical processes.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.

Neural tracts connecting one part of the nervous system with another.

A mechanism of communication with a physiological system for homeostasis, adaptation, etc. Physiological feedback is mediated through extensive feedback mechanisms that use physiological cues as feedback loop signals to control other systems.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.

The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.

Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

Proteins that are involved in or cause CELL MOVEMENT such as the rotary structures (flagellar motor) or the structures whose movement is directed along cytoskeletal filaments (MYOSIN; KINESIN; and DYNEIN motor families).

The function of opposing or restraining the excitation of neurons or their target excitable cells.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.

A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.

The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.

Nerve structures through which impulses are conducted from a nerve center toward a peripheral site. Such impulses are conducted via efferent neurons (NEURONS, EFFERENT), such as MOTOR NEURONS, autonomic neurons, and hypophyseal neurons.

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.

Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.

Refers to animals in the period of time just after birth.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.

The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.

The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.

The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.

Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

The pattern of any process, or the interrelationship of phenomena, which affects growth or change within a population.

A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.

The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

A microtubule-associated mechanical adenosine triphosphatase, that uses the energy of ATP hydrolysis to move organelles along microtubules toward the plus end of the microtubule. The protein is found in squid axoplasm, optic lobes, and in bovine brain. Bovine kinesin is a heterotetramer composed of two heavy (120 kDa) and two light (62 kDa) chains. EC 3.6.1.-.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

The lower portion of the BRAIN STEM. It is inferior to the PONS and anterior to the CEREBELLUM. Medulla oblongata serves as a relay station between the brain and the spinal cord, and contains centers for regulating respiratory, vasomotor, cardiac, and reflex activities.

A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

The functional hereditary units of INSECTS.

An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.

The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

The relationships of groups of organisms as reflected by their genetic makeup.

The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.

A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS.

Proteins which are involved in the phenomenon of light emission in living systems. Included are the "enzymatic" and "non-enzymatic" types of system with or without the presence of oxygen or co-factors.

The subfamily of myosin proteins that are commonly found in muscle fibers. Myosin II is also involved a diverse array of cellular functions including cell division, transport within the GOLGI APPARATUS, and maintaining MICROVILLI structure.

Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains.

The rate dynamics in chemical or physical systems.

Proteins found in any species of bacterium.

Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.

The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)

The observable response an animal makes to any situation.

A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.

The quality of surface form or outline of CELLS.

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

The splitting of an ancestral species into daughter species that coexist in time (King, Dictionary of Genetics, 6th ed). Causal factors may include geographic isolation, HABITAT geometry, migration, REPRODUCTIVE ISOLATION, random GENETIC DRIFT and MUTATION.

A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.

A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.

An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

The properties, processes, and behavior of biological systems under the action of mechanical forces.

Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.

The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.

Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Biological actions and events that support the functions of the RESPIRATORY SYSTEM.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Sexual activities of animals.

The spread of response if stimulation is prolonged. (Campbell's Psychiatric Dictionary, 8th ed.)

DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.

The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)

An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.

Genotypic differences observed among individuals in a population.

A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.

Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).

Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.

Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

A dynamic actin-rich extension of the surface of an animal cell used for locomotion or prehension of food.

The total process by which organisms produce offspring. (Stedman, 25th ed)

The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.

The assembly of the QUATERNARY PROTEIN STRUCTURE of multimeric proteins (MULTIPROTEIN COMPLEXES) from their composite PROTEIN SUBUNITS.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.

Changes in biological features that help an organism cope with its ENVIRONMENT. These changes include physiological (ADAPTATION, PHYSIOLOGICAL), phenotypic and genetic changes.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).

Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).

Transport proteins that carry specific substances in the blood or across cell membranes.

The processes whereby the internal environment of an organism tends to remain balanced and stable.

The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.

Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.

The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.

Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

A cell line generated from human embryonic kidney cells that were transformed with human adenovirus type 5.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.

The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.

Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.

Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.

A protein complex of actin and MYOSINS occurring in muscle. It is the essential contractile substance of muscle.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

A condition characterized by abnormal posturing of the limbs that is associated with injury to the brainstem. This may occur as a clinical manifestation or induced experimentally in animals. The extensor reflexes are exaggerated leading to rigid extension of the limbs accompanied by hyperreflexia and opisthotonus. This condition is usually caused by lesions which occur in the region of the brainstem that lies between the red nuclei and the vestibular nuclei. In contrast, decorticate rigidity is characterized by flexion of the elbows and wrists with extension of the legs and feet. The causative lesion for this condition is located above the red nuclei and usually consists of diffuse cerebral damage. (From Adams et al., Principles of Neurology, 6th ed, p358)

Nucleic acid sequences involved in regulating the expression of genes.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.

A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.

Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.

A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.

The genetic unit consisting of three structural genes, an operator and a regulatory gene. The regulatory gene controls the synthesis of the three structural genes: BETA-GALACTOSIDASE and beta-galactoside permease (involved with the metabolism of lactose), and beta-thiogalactoside acetyltransferase.

The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.

The capability of an organism to survive and reproduce. The phenotypic expression of the genotype in a particular environment determines how genetically fit an organism will be.

Drug addiction as drive satisfaction ("antidrive") dysfunction. (1/52)

Drug addiction is a complex brain disorder, characterized by the loss of control over drug seeking and drug taking behavior, and by the risk of relapse, even after a prolonged period of abstinence. This disorder may have its source in a disturbed balance of drive-related behaviors, which control appetitive reactions aimed at seeking contact with an addictive substance. The act of consumption becomes more and more attractive, and the behavior takes on compulsive character. We suppose that drug addiction may involve a change in the mechanism of satisfaction of drives and states of satiation as well. To understand how the motivational processes are changed with the development of dependence, one must consider the mechanism of drive satisfaction and satiation states that occur in relation to the consumatory reflex. When a given drive is satisfied a state of fulfillment occurs. This state may be a result of a so-called "antidrive" mechanism (Konorski 1967). While a drive activity is characterized by general activation and tension, the drive satisfaction state ("antidrive") is characterized by relaxation and relief. When a particular drive is satisfied, the operation of other drives become possible. Therefore, we postulate that dysfunction of drive satisfaction leads to the sustained activation related to the current drug-related drive, which blocks the operation of other drives. In effect, uncontrolled compulsive appetitive behavior is released, and the operation of other drives is restrained, thus forcing the organism to focus on drug-related drive. The reason for an "antidrive" dysfunction may be related to adaptive changes which develop during a contact with an addictive substance. (+info)

Bradykinin stimulates respiratory drive by activating pulmonary sympathetic afferents in the rabbit. (2/52)

We recently identified a vagally mediated excitatory lung reflex by injecting hypertonic saline into the lung parenchyma (Yu J, Zhang JF, and Fletcher EC. J Appl Physiol 85: 1485-1492, 1998). This reflex increased amplitude and burst rate of phrenic (inspiratory) nerve activity and suppressed external oblique abdominal (expiratory) muscle activity. In the present study, we tested the hypothesis that bradykinin may activate extravagal pathways to stimulate breathing by assessing its reflex effects on respiratory drive. Bradykinin (1 microg/kg in 0.1 ml) was injected into the lung parenchyma of anesthetized, open-chest and artificially ventilated rabbits. In most cases, bradykinin increased phrenic amplitude, phrenic burst rate, and expiratory muscle activity. However, a variety of breathing patterns resulted, ranging from hyperpnea and tachypnea to rapid shallow breathing and apnea. Bradykinin acts like hypertonic saline in producing hyperpnea and tachypnea, yet the two agents clearly differ. Bradykinin produced a higher ratio of phrenic amplitude to inspiratory time and had longer latency than hypertonic saline. Although attenuated, bradykinin-induced respiratory responses persisted after vagotomy. We conclude that bradykinin activates multiple afferent pathways in the lung; portions of its respiratory reflexes are extravagal and arise from sympathetic afferents. (+info)

Reward processing in the brain: a prerequisite for movement preparation? (3/52)

In the last decade, expanding animal studies on the cerebral organization of reward processing toward human in vivo situations has become possible. In this review, we define some of the concepts associated with reward, summarize the crucial importance of the dopaminergic system, and discuss the currently available neuroimaging studies in man. We will show that abstract concepts of human behavior like emotions, drive, arousal, and reinforcement are now open for further exploration in man at the level of neuronal circuit organization. The cerebral dopaminergic neurotransmitter circuitry does play an important role in the organization of both the motor and motivational system. (+info)

The differential effect of conation on intelligence test scores among brain-damaged and control subjects. (4/52)

Conation, or the ability to apply effective effort in completing a task over time, has been shown to be impaired in brain-damaged subjects. Various intelligence tests differ in the apparent extent to which they require conative ability. In this study we compared results earned by brain-damaged and control groups on three measures of intelligence: Wechsler Verbal IQ (VIQ), Wechsler Performance IQ (PIQ), and the Henmon-Nelson Test (HNT) of Mental Ability. Test scores were converted to T-score distributions for the combined groups in order to delete possible effects of differences in standardization procedures and the normative samples on which IQ scores were generated. The degree of impairment shown by the brain-damaged subjects was in direct relationship to the extent to which the three intelligence measures appear to require conation. The results support a generalization that intelligence tests that require a greater conative ability tend to produce lower scores for brain-damaged persons, as compared to controls, than do intelligence tests that are less demanding of conation. (+info)

Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinness. (5/52)

Several lines of evidence suggest that a disturbance of serotonin neuronal pathways may contribute to the pathogenesis of anorexia nervosa (AN) and bulimia nervosa (BN). This study applied positron emission tomography (PET) to investigate the brain serotonin 2A (5-HT(2A)) receptor, which could contribute to disturbances of appetite and behavior in AN and BN. To avoid the confounding effects of malnutrition, we studied 10 women recovered from bulimia-type AN (REC AN-BN, > 1 year normal weight, regular menstrual cycles, no binging, or purging) compared with 16 healthy control women (CW) using PET imaging and a specific 5-HT(2A) receptor antagonist, [18F]altanserin. REC AN-BN women had significantly reduced [18F]altanserin binding potential relative to CW in the left subgenual cingulate, the left parietal cortex, and the right occipital cortex. [18F]altanserin binding potential was positively related to harm avoidance and negatively related to novelty seeking in cingulate and temporal regions only in REC AN-BN subjects. In addition, REC AN-BN had negative relationships between [18F]altanserin binding potential and drive for thinness in several cortical regions. In conclusion, this study extends research suggesting that altered 5-HT neuronal system activity persists after recovery from bulimia-type AN, particularly in subgenual cingulate regions. Altered 5-HT neurotransmission after recovery also supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of eating disorders. It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects. (+info)

Role of voluntary drive in encoding an elementary motor memory. (6/52)

Motor training consisting of repetitive thumb movements results in encoding of motor memories in the primary motor cortex. It is not known if proprioceptive input originating in the training movements is sufficient to produce this effect. In this study, we compared the ability of training consisting of voluntary (active) and passively-elicited (passive) movements to induce this form of plasticity. Active training led to successful encoding accompanied by characteristic changes in corticomotor excitability, while passive training did not. These results support a pivotal role for voluntary motor drive in coding motor memories in the primary motor cortex. (+info)

The etymology of basic concepts in the experimental analysis of behavior. (7/52)

The origins of many of the basic concepts used in the experimental analysis of behavior can be traced to Pavlov's (1927/1960) discussion of unconditional and conditional reflexes in the dog, but often with substantial changes in meaning (e.g., stimulus, response, and reinforcement). Other terms were added by Skinner (1938/1991) to describe his data on the rate of lever pressing in the rat (e.g., operant conditioning, conditioned reinforcement, negative reinforcement, and response induction and differentiation) and key pecking in the pigeon (shaping). The concept of drive, however, has largely disappeared from the current literature. (+info)

Perception of the consequences of self-action is temporally tuned and event driven. (8/52)

It has been proposed that in order to increase the salience of sensations with an external cause, sensations that are predictable based on one's own actions are attenuated [1 and 2]. This may explain why self-imposed tickle [3 and 4] or constant forces [5] are perceived as less intense than the same stimuli externally imposed. Here, subjects used their right index finger to tap a force sensor mounted above their left index finger. When a motor generated a tap on the left finger synchronously with the right tap, simulating contact between the fingers, the perception of force in the left finger was attenuated compared to the same tap experienced during rest. Attenuation gradually reduced as the left tap was either delayed or advanced relative to the active right tap. However, no attenuation was seen to left taps triggered by right-finger movements that stopped above or passed wide of the sensor. We conclude that there is a window of sensory attenuation that is broadly temporally tuned and centered on the time at which the fingers would normally make contact. That is, predictive tactile sensory attenuation is linked to specific external events arising from movement rather than to the movement per se. (+info)

CS1 maint: discouraged parameter (link) "Transurban to sue over tunnel 'flaws'". Drive. Fairfax Media. 22 January 2007. ...

https://en.wikipedia.org/wiki/Burnley_Tunnel

Morley, David (23 August 2006). "Ford Falcon BA". Drive. Retrieved 7 December 2006. "Used Car Review Ford Falcon BA". AutoWeb. ... Pettendy, Marton (30 September 2003). "First drive: Ford's tough Falcon RTV ute". GoAuto. Retrieved 18 March 2009. Doug, Bevan ... McKinnon, Bill (19 September 2003). "How to play the trade-in game". Drive. Retrieved 27 June 2007.. ...

https://en.wikipedia.org/wiki/Ford_Falcon_(BA)

She used 2006 as a year to gain experience in a rear-wheel drive rally car before moving into a front-wheel drive car and ... Barari, Aman (12 July 2011). "WRC's Only Female Drive Gears Up For Home Rally". Motor Ward. Retrieved 22 March 2013. Mckay, ... Ottley, Stephen (12 November 2010). "Rallying To The Cause". Drive.com (Sydney Morning Herald). Retrieved 22 March 2013. " ... McCowen, David (23 November 2016). "Molly Taylor wins Australian Rally Championship with Subaru". Drive. Retrieved 29 September ...

https://en.wikipedia.org/wiki/Molly_Taylor

Hall, Sam (30 May 2013). "First drive review: Holden VF Calais V V6". Drive. Archived from the original on 7 August 2013. ... Blackburn, Richard (30 May 2013). "First drive review: Holden VF Calais V V8". Drive. Archived from the original on 2 September ... McKay, Peter (30 May 2013). "First drive review: Holden VF Commodore Evoke". Drive. Archived from the original on 20 June 2013 ... MacLean, Andrew (30 May 2013). "First drive review: Holden VF Commodore SV6 Sportwagon LPG". Drive. Archived from the original ...

https://en.wikipedia.org/wiki/Holden_Commodore_(VF)

Attwood, Alan (3 December 2001). "Race marshal inquest opens today". Drive. Archived from the original on 6 May 2019. Retrieved ...

https://en.wikipedia.org/wiki/2001_Australian_Grand_Prix

... or all-wheel drive. This is a major departure from the V8 and rear wheel drive variants available on the previous generation ... moving to a front-wheel drive (FWD)/all-wheel drive (AWD) platform. On 10 December 2019, Holden announced that the Commodore ... Launched in 2006 after GM's 2003 abandonment of their last European rear-drive sedan, the Opel Omega, the VE is the first ... The 2018 Commodore was to be offered with four or six-cylinder engine options, as well as front-wheel drive (FWD) ...

https://en.wikipedia.org/wiki/Holden_Commodore

"2017 Holden Astra sedan first drive review". Drive.com.au. Pettendy, Marton (18 July 2011). "First look: Opel outs next Combo ... "The last Right-hand drive cars". canadianponcho.activeboard.com. "Car review - Holden Suburban 1500 LT 5-dr wagon". GoAuto. ... "Malibu drives down centre lane". 16 June 2013 - via www.nzherald.co.nz. "Holden Spark 2019 Range , Holden New Zealand". Holden. ... By 2020, Australia, New Zealand, and Thailand were the only GM right-hand-drive markets left. With Holden new-car sales in its ...

https://en.wikipedia.org/wiki/Holden_New_Zealand

Drive. "Seiichi Ikiuo Video Game Credits and Biography". MobyGames. Retrieved 13 April 2019. "Polyphony Digital - #24 Top Video ...

https://en.wikipedia.org/wiki/Polyphony_Digital

All models are only available with all-wheel drive (xDrive), and meet Euro 6 emission regulations. 2015 BMW X4 xDrive28i 2015 ... "BMW X4 xDrive20d review , Car review , RAC Drive". www.rac.co.uk. Retrieved 29 June 2018. "BMW X4 Estate (2014 - ) Features, ... Rae, Alex (6 March 2018). "Alpina reveals world's fastest diesel SUV - The world's fastest diesel SUV". Drive. Retrieved 15 ... It is available in left-hand drive markets only. Wilson, Kevin A. (29 May 2019). "The 2019 BMW X4 Proves That No Niche Is Too ...

https://en.wikipedia.org/wiki/BMW_X4

"Drive". ITV. 14 January 2016. Retrieved 15 January 2016. "Chopping Block". ITV Press Centre. ITV. 24 March 2016. Retrieved 29 ...

https://en.wikipedia.org/wiki/2016_in_British_television

London, Luxury (2020-02-04). "Espen Øino: Superyacht Designer Extraordinaire , Yachts & Jets , Drive". Luxury London. Retrieved ...

https://en.wikipedia.org/wiki/Kristian_Stensby

Kelby meanwhile sabotages the warp drive before Commander Tucker can physically stop him. Afterwards, Doctor Phlox determines ... Hines, Edward James (October 25, 2000). "Drive". TrekNation. Retrieved May 30, 2013. "The Darkness and the Light". TrekNation. ... "Drive", an episode Star Trek: Voyager, as Irina. William Lucking had appeared as a Bajoran called Furel in three episodes of ...

https://en.wikipedia.org/wiki/Bound_(Star_Trek:_Enterprise)

"Drive song Black Car: Sushant Singh Rajput, Jacqueline Fernandez go for a ride but fans ask why cars are red". Hindustan Times ... Other than this the duo has composed songs for Munna Michael, Julie 2, Jalebi and Drive. Besides the film, the duo has composed ... "Black Car , Drive , Sushant Singh Rajput & Jacqueline Fernandez , Javed-Mohsin , Suraj Chauhan, Shivi & Ariff Khan , Video ... Jalebi and Drive. Javed- Mohsin are the first cousins related from their maternal side. Javed Khan's father was a tabla player ...

https://en.wikipedia.org/wiki/Javed–Mohsin

The wheel was driven directly from the transmission, eliminating the drive chain and the oil and dirt associated with it. The ... The Vespa's enclosed, horizontally mounted 98 cc two-stroke engine acted directly on the rear drive wheel through a three-speed ... "Vespa Production Starts in Vietnam". Drive. 2017. Retrieved 23 October 2018. Doval, Pankaj (2012-01-08). "Auto Expo 2012: 13 ...

https://en.wikipedia.org/wiki/Vespa

Collie, Scott (4 June 2019). "Tesla Model X joins Victorian Highway Patrol fleet , Drive Car News". Drive. Retrieved 16 ... "Rent or test drive a Tesla in Australia l Electric car hire". Evee. Retrieved 3 January 2021. "Tesla Taxi , Car Club". Tesla ... Two of the world's largest right-hand-drive markets are intending to eliminate petrol and diesel vehicle sales by 2030. For ... "Cayenne". Drive. 7 April 2021. Retrieved 17 April 2021. "Raine One". Raine Electric Scooters. Retrieved 17 April 2021. Schmidt ...

https://en.wikipedia.org/wiki/Plug-in_electric_vehicles_in_Australia

McCowen, David (9 March 2017). "Exclusive: Behind the scenes with the new McLaren 720S". Drive. Retrieved 24 March 2017. " ...

https://en.wikipedia.org/wiki/Robert_Melville_(car_designer)

Sonnery, Marc (31 January 2020). "1969 Thomassima III". Drive. Retrieved 2020-04-19. "Meade'n Voyage". The Auto Channel. ...

https://en.wikipedia.org/wiki/Tom_Meade

Hagon, Toby (20 March 2008). "First drive: Pontiac G8". Drive. Archived from the original on 11 March 2012. Retrieved 12 ... In 2007, the same model was exported to the Middle East badged as the CSV CR8, albeit in left hand drive. In this instance, CSV ... "First drive: Holden VE Sportwagon". Herald Sun. 11 July 2007. Archived from the original on 28 March 2011. Retrieved 22 July ... The front-wheel drive Mitsubishi 380 also indirectly competed with the Holden Commodore, but was discontinued with the 2008 ...

https://en.wikipedia.org/wiki/Holden_Commodore_(VE)

"Hyundai Grand i10 review, test drive and video". Autocar India. Retrieved 2020-10-11. "Euro-spec next-gen 2020 Hyundai i10 ... The architecture supports electrified variants, and unlike the GB platform, the new platform supports an all-wheel-drive ... Hagon, Toby (2017-06-15). "Official: Hyundai Kona revealed - Official: Hyundai Kona revealed". Drive. Retrieved 2020-12-11. " ...

https://en.wikipedia.org/wiki/Hyundai-Kia_small_automobile_platforms

... all with rear-wheel drive; additionally there was the 250 L/LV Four featuring all-wheel drive and a turbocharged version of ... Alston, Josh (12 June 2019). "The time that Mazda and Holden released a hybrid vehicle , TMR". Drive. Retrieved 5 February 2020 ...

https://en.wikipedia.org/wiki/Nissan_Cedric

Information Retrieved from www.tseries.info on 28 November 2008 drive.com.au (4 October 2016). "Jaguar F-Type Project 7". Drive ... In the spring of 2009 the Peterborough site was closed and the work transferred to the Milton Keynes facility in Tanners Drive ...

https://en.wikipedia.org/wiki/Tickford

... the Chevrolet Camaro 2SS coupe and Chevrolet Silverado 2500HD pick-up truck from left-hand-drive to right-hand-drive to GM's ... In HSV models, this engine was used with a higher than standard 3.91:1 final drive ratio. Power: 215 kW (292 PS; 288 hp) at ... Avalanche The HSV Avalanche is an all-wheel drive crossover SUV that was produced from 2003 to 2005. Based on the Holden ... In 2004, the GTS was discontinued and the all-wheel drive Coupé4 introduced. Limited edition models included the GTO LE (2003 ...

https://en.wikipedia.org/wiki/Holden_Special_Vehicles

All-wheel drive By far the biggest highlight of the TJ Series 2 was the introduction of the sedan-only Magna/Verada AWD range, ... Pettendy, Marton (25 June 2004). "First drive: Magna VR-X gets a grip on AWD". GoAuto. Retrieved 27 April 2016. "Magna and ... The third and final iteration Magna/Verada launched in 1996, adding all-wheel-drive (AWD) from 2002, and receiving a ... Mitsubishi developed the Magna as a replacement for the rear-wheel drive (RWD) Sigma. Previously, Mitsubishi had a larger ...

https://en.wikipedia.org/wiki/Mitsubishi_Magna

The production Cruze had standard front-wheel drive, with all-wheel drive optional. Chevrolet pursued a marketing strategy that ... This multimedia system integrates satellite navigation, the CD and DVD players, and a 10 GB internal hard disk drive. In mid- ... Prime Minister Julia Gillard attended the February launch to drive the first example off Holden's production line before full- ... Toby, Hagon (May 19, 2009). "Holden set to abandon Astra". Drive. Archived from the original on July 22, 2011. Retrieved July ...

https://en.wikipedia.org/wiki/Chevrolet_Cruze

"Bob Harper BMW E65". Drive. Retrieved 19 February 2018. "BMW E65 - Drive". drive-my.com. Retrieved 3 June 2017. "BMW 7er, ... "BMW 760Li - First Drive Review". caranddriver.com. Retrieved 18 May 2017. "An Interview with BMW's Chief Designer". Bloomberg L ... "2004 745 New Car Test Drive". autoblog.com. Retrieved 13 June 2017. "2003 BMW 760Li vs. M-B S600 - Comparison Tests". ...

https://en.wikipedia.org/wiki/BMW_7_Series_(E65)

Morley, David (27 February 1999). "Fast Movers with a Soft Touch". Drive. Fairfax Media. Retrieved 22 March 2009. Wright (1998 ... with a 3.45 or 3.23 Final Drive ratio with a Limited-Slip version available as an option. This was taller than the ratio ...

https://en.wikipedia.org/wiki/Holden_Commodore_(VL)

"Drive Car of the Year". Drive. Retrieved 5 December 2020. China Car Awards. http://www.ccoty.cn/china-car-award/ "GERMAN CAR OF ... 60 automotive journalists from the US and Canada Drive Car of the Year (Australia) Wheels magazine's Car of the Year (Australia ...

https://en.wikipedia.org/wiki/Car_of_the_Year

The initial four-speed automatics suffered poor reliability with loss of drive common within the first 100,000 km (62,000 mi). ... Wright, John (26 February 1999). "Used car test - Ford Fairlane". Drive. Archived from the original on 6 July 2011. Retrieved ... it would retain the traditional Falcon hallmarks of width and rear-wheel drive. This proved to be the correct move as sales of ...

https://en.wikipedia.org/wiki/Ford_Falcon_(EA)

All 70 kWh cars can be had with rear-wheel drive or all wheel drive. The 60 was re-introduced in 2016 as a software-limited 75 ... In the P85D, the high-power rear-drive unit is retained, while the additional front-drive motor boosts the total power by about ... On October 9, 2014, Tesla announced the introduction of "Dual Drive" all-wheel drive (AWD) versions of the Model S 60, 85, and ... in part due to the improved traction of the all-wheel drive powertrain. The Model S P85D, a dual-motor all-wheel-drive vehicle ...

https://en.wikipedia.org/wiki/Tesla_Model_S

In 2011, Eaton raced a rear wheel drive Mazda MX-5 Cup car. After a tough season missing several rounds due to a lack of budget ... In 2017, Eaton began with a year out, and was then offered a one off drive for the 2017 Blancpain GT Series in a Ferrari 488 ... In the Mercedes, Eaton says "Right, here we go" to herself, before starting the lap and completing the test drive silently. ... she appareaed [sic] on ITV's Drive in 2015, coaching rapper Professor Green in a variety of racing challenges over the course ...

https://en.wikipedia.org/wiki/Abbie_Eaton

Get started with Drive for free. Go to Google Drive Download Google Drive Download Google Drive Go to Google Drive ... Go to Google Drive Download Google Drive Download Google Drive Go to Google Drive ... With Drive Enterprise, businesses only pay for the storage employees use. It comes with Google Docs, Sheets, and Slides - and ... Your files in Drive can be reached from any smartphone, tablet, or computer. So wherever you go, your files follow. ...

https://www.google.com/drive/

Want a 1TB optical drive? Call/Recall me. Backwards compatible with Blu-ray. By Chris Mellor 28 May 2008 at 13:58 ... The use of pretty standard components apart from the lens and recording layer should make for a more affordable drive than ... Call/Recall has announced it is developing a 1TB optical drive and disk, backwards compatible with Blu-ray, in partnership with ... The I/O rate is said to be around 100MB/sec, five times faster than InPhases holographic drives. ...

http://www.theregister.co.uk/2008/05/28/call_recall_optical_drive/

This staff member is a UQ Expert for media in the following fields: Relationships, Child and family issues, Psychology, Psychiatry, Behaviour, Mental health, Behavioural medicine, Psychonutrition They are happy to lend their expertise to your articles or broadcasts and share their research discoveries and insights with the community via media channels. For additional assistance with story ideas, general advice and information or help with seeking further experts, please email the UQ Media Team or telephone (07) 3365 1120. ...

http://researchers.uq.edu.au/researcher/986

... is the Convenor of the 2012 ACMA Gala Dinner with 250+ attendants at Crystal Palace Sydney (Raised in excess of ... Dr. Jenson Mak always says, Aim far, dream further, achieve the best! ... AUD$25000 for 2 organizations delivering services for children with disabilities - Northcott and Woodbury). Dr. Jenson Mak ... Dr. Jenson Mak speaks fluently in English, Can… Read More. Outside of his medical practice, Dr. Jenson Mak is the Convenor of ...

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Dr Bernard M Corfe BSc PhD. Senior Lecturer in Oncology. Principal Investigator in Molecular Gastroenterology. Fellow of ...

https://www.sheffield.ac.uk/oncology-metabolism/staff/corfe

Pfizers Dr. Freda Lewis-Hall explains how, with medical advances, pregnancy can be reality for women with Rheumatoid Arthritis ... Have a Story Dr. Phil Wont Believe? Want to appear on Dr. Phil? Text PHIL to 88500 ... Dr Phils Advice. Dr Phils Advice. *Post-Traumatic Stress Disorder: The Symptoms ... Dr. Phil To Guests Who Claim Their Sons Are Out Of Control: I Need You To Stop Sabotaging These Boys ...

https://www.drphil.com/videos/dr-freda-lewis-hall-on-medical-advances-that-can-make-pregnancy-a-reality-for-women-with-rheumatoid-arthritis/

I am going to implement the protocol Dr. Eisen outlined and time will tell. Also Dr. Eisens dog didnt just live "longer", the ... To me what Dr Eisen says makes sense. I have changed my dogs diet and just that alone helped her with a month long gastro ... The fact that Dr. Eisens made up claims about it "make sense" to you just means that you share his biases, not that there is ... Dr. Eisen makes stuff up. If the difference isnt clear to you, that is more a reflection of your own ideology than of the fact ...

http://skeptvet.com/Blog/2012/07/dog-cancer-expert-steven-eisen-bad-advice-from-an-unreliable-source-revised/

... I Suture Testiomonial Dr. Plummer Associate Professor, University of Florida Diplomate, American College of Veterinary ... Dr. Caryn Plummer is a board-certified veterinary ophthalmologist working in academic medicine at Florida State University in ... KRUUSE I Suture Testiomonial Dr. Plummer Associate Professor, University of Florida Diplomate, American College of Veterinary ...

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Technorati Tags: hair restoration, Hair Transplant, Dr. Richard Keller, Coalition of Independent Hair Restoration Physicians, ... This month, we are proud to present Coalition member, Dr. Richard Keller of Deerfield, Illinois. ... Dr. Keller lives in the suburbs with his wife and two dogs. He also has two grown children in graduate school that he calls his ... Dr. Keller promotes the concept of one patient focus per day to provide the one on one care that his patients deserve. He ...

http://www.regrowhair.com/hair-loss-blog/physician-spotlight-hair-transplant-surgeon-dr-richard-keller/

Save a life by donating blood at Whole Foods Market. Make your appointment online with the South Texas Blood & Tissue Center [1]. All presenting donors will receive a t-shirt and a gift card to Whole Foods Market.. ...

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"Hard drive" redirects here. For other uses, see Hard drive (disambiguation).. Hard disk drive. Internals of a 2.5-inch SATA ... RAID subsystems are multiple drives that appear to be one drive or more drives to the user, but provide fault tolerance. Most ... In drive arrays, one drives failure significantly increases the short-term risk of a second drive failing. ... "Portable" drives are packaged in smaller and lighter enclosures than the "desktop" drives; additionally, "portable" drives use ...

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Drive enables teams to quickly and securely share and exchange large files and directories directly from the desktop. ... Aspera Drive allows remote browsing of projects and Shares directly from the desktop in Microsoft Windows Explorer and Apple ... IBM® Aspera® Drive handles extremely large files and data sets easily-including entire directory structures. It transfers and ... Aspera Drive combines authorization and access control for multilayered security, and provides security for data access and ...

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... for first year drives to over 8.6% for three-year-old drives.[17] A similar 2007 study at CMU on enterprise drives showed that ... Some hard disk drives simply fail because of worn out parts,[1][clarification needed] others fail prematurely. Drive ... Signs of drive failure[edit]. Failure of a hard disk drive can be catastrophic or gradual. The former typically presents as a ... Some early drives even had a table attached to a drives case on which bad sectors were to be listed as they appeared.[12] ...

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Dr. Kam Kalantar. Dr. Kalantar. Kamyar Kalantar-Zadeh, MD, MPH, PhD,. FAAP, FACP, FASN, FAHA, FNKF. Professor of Medicine and ... Click Here to see Dr. Kalantars major publications. If you have a kidney disease, call. Dr. Kalantar (pronounced as Calendar) ... Click Here to see Dr. Kalantars major publications. Dr. Kalantar. KAMYAR KALANTARZADEH, M.D., M.P.H., Ph.D.. F.A.C.P., F.A.A.P ... Dr. Kalantars publications listed in Medline (PubMed). Harbor-UCLA Medical Center Los Angeles Biomedical Research Institute. ...

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4. The ZIP drive. There are at least five or six versions of the Iomega ZIP 100 drive. The Iomega page for these drives is at ... The copy going to the hard drive was only 50 seconds. The copy from the hard drive to the Zip drive was only 40 seconds. ... The copy to the C drive was 1:55 seconds. From the hard drive to the Zip drive was 1 minute flat. This compares to 7:15 and 7: ... 8.9 Can PPA be used with Iomegas parallel port tape drives ? No. Those drives are floppy-tape drives. There is no SCSI ...

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http://www.finaldrivemotors.com/ We sell replacement excavator final drive motors at wholesale prices, with free Continental U. ... We sell replacement excavator final drive motors at wholesale prices, with free Continental U.S shipping and our industry first ...

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IBM TS1150 Tape Drive. 降低大數據、雲端、行動和社群環境的長期

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Brazil is trying to get more women to breastfeed their babies with a high-profile publicity drive. But parts of the campaign ... "The tone of this campaign makes some women feel persecuted," says Dr Leonardo Posternak, a 30-year veteran of child medicine. " ... "Its a social and economic problem," declares Dr Leilia Cardamone, a specialist in child nutrition. "Rich, educated Brazilians ... The Brazilian scientific community is broadly supportive of the publicity drive, although aspects of the campaign are proving ...

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Flash drives up to 2TB have been tested. GPS and WiFi capable.. ... can also record and playback video from your PCs hard drive.. ...

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All donations for Dr. Jones, made through this sites PayPal account, a credit card, or by US postal mail, are sent to him ... This website is dedicated to Dr. Charles Ray Jones and his precious kids. ... directly and are considered charitable gifts. Dr. Jones and his angles in the office thank you so much for the gifts they ...

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... sometimes called a micro drive rear hub, sprockets as small as 8 teeth may be used. The advantage of micro drive is that it ... Micro drive is a type of bicycle drivetrain, mostly BMX and MTB, that uses smaller than standard-sized sprockets. The smallest ... The disadvantage is increased stresses on the drive train, leading to increased wear and even premature failure. As the front ... "Suntour Components Catalog 1992: MD (Micro Drive Design)" (PDF). The Bicycle Info Project. Retrieved 2011-08-18. Smallest rings ...

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The Governors Drive is also home to many known places and landmarks. Such malls like SM City Dasmariñas, SM City Trece ... Governors Drive towards the provincial boundary with Laguna starts near SM City Dasmariñas at the Pala-pala intersection with ... Governors Drive toward Ternate starts also at the intersection with Aguinaldo Highway at Pala-Pala, near Robinsons Place ... Road, formerly and still referred to as Governors Drive, is a two-to-nine lane, 58.3-kilometer (36.2 mi) network of primary, ...

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Kyle Berkshire, World Long Drive Champion - 2019 Maurice Allen, World Long Drive Champion - 2018 Justin James, World Long Drive ... drive (lost Long Drive contest to Jamie Sadlowski) Alan Shepard, "Miles and miles and miles." Apollo 14, February 5, 1971. ( ... "World Long Drive Association Announces Rule Change". World Long Drive. 18 November 2016. Retrieved 6 June 2017. "The Longest ... Monte Scheinblum, 1992 U.S. National and World Long Drive Champion. Jason Zuback ("Golfzilla"), World Long Drive Champion 1996 ...

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If you are shopping in this segment, and want to buy a domestic product, the Durango should be on your must-test-drive list.. ... Standard on four-wheel-drive models is the carryover 4.7-liter V8 with 230 horses and 290 lb-ft. For maximum towing and hauling ... The standard power plant for two-wheel-drive Durangos is a 3.7-liter V6 that supplies 210 horsepower and 235 pound-feet of ... As before, four-wheel-drive Durangos come with dual-range transfer cases for serious off-roading.. Four-wheel antilock disc ...

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The Red Cross will conduct a Blood Drive at Caltech. Monday, September 23 from 8:00 AM - 8:00 PM in the Winnett Quad. Look for ... On Tuesday, September 24 the Red Cross Blood Drive will be held in the Winnett Lounge (above the Bookstore Bldg. #51 on the ...

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Media in category "Friction drive". The following 17 files are in this category, out of 17 total. ... 1906 Lambert chassis with disk drive transmission.png 2,828 × 2,116; 5.08 MB. ... Friction drive (en) mechanical power transmission by friction between components (en) ... Retrieved from "https://commons.wikimedia.org/w/index.php?title=Category:Friction_drive&oldid=334433372" ...

https://commons.wikimedia.org/wiki/Category:Friction_drive

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What can I do to counteract stress and improve my sex drive? (medicinenet.com)
Is there anything I can eat to improve my sex drive? (medicinenet.com)

Starting on July 10, 2019 , Google Photos will no longer sync to Google Drive . (linux.org)
From that date forward, if you add or delete files in Photos, they won't be automatically added or deleted in Drive .Jun 12, 2019 and. (linux.org)

Search for google drive alternatives. (linux.org)
Google just announced five small updates to Google Drive: search by person, view Google Earth map files, create new folders while organizing files, drag and drop folders in Chrome, and search includes your trash. (thenextweb.com)
Takeda officials presented the doll to Orlando scientists, including Dr. Steven Smith (left) and Dr. Daniel Kelly (middle), who will be collaborating with the Japanese drugmaker in search of a new obesity drug. (latimes.com)

GREENVILLE, S.C. - The Greenville Drive, in conjunction with Major League Baseball, Minor League Baseball, and the South Atlantic League today announced that the 2020 season has been cancelled due to the continuing COVID-19 pandemic that has swept across the world. (milb.com)
While the Drive have continued to prepare for a rescheduled Opening Night, including revising and updating health and safety protocols, the complexity of the issues created by the COVID 19 virus were simply too great to overcome for minor league baseball to have its 2020 season. (milb.com)

As a product, Drive replaces Docs and Google launched the product for its Enterprise suite users as well. (zdnet.com)
Evan is a Docs & Drive expert and author of this help page. (google.com)
The latest versions of Google Drive, Docs, Sheets, Slides, and Forms are compatible with the following operating systems and browsers. (google.com)
Google Drive, Docs, Sheets, Slides, and Forms work with the 2 most recent versions of the following browsers (unless specified otherwise). (google.com)

Drive Activity API v1 has reached the end of its deprecation period and is shutting down as announced in December 2018. (google.com)

Dr. O'Neill thanked the officials from the New York City Department of Health and Mental Hygiene for hosting the first day of the meeting, and welcomed Dr. Steve Solomon, Director of Centers for Disease Control and Prevention (CDC) Coordinating Center for Health Information and Service (CCHIS), who attended as a guest. (cdc.gov)
Dr. Solomon said that the NCHS BSC will be a model for BSC's being created in the other CCHIS centers. (cdc.gov)

This year, the industry experienced another leap in capacity with the introduction of 1-terabyte desktop hard drives like the Hitachi Deskstar 7K1000 . (techspot.com)
For maximum data processing, hard drive manufacturers offer drives with up to 32MB of cache today, as it is the case with the terabyte drive. (techspot.com)

Suntour Components Catalog 1992: MD (Micro Drive Design)" (PDF). (wikipedia.org)
Dr. Frankel has been working in the field of acute stroke research since 1992. (emory.edu)
A selection of clocks from the Dr. Hugh Grant Rowell Collection, along with books, letters, and other horological materials, was exhibited in the corridor windows of Baker Library from 1 May to 2I June 1992. (dartmouth.edu)

The air filters on today's drives equalize the atmospheric pressure and moisture between the drive enclosure and its outside environment. (wikipedia.org)
With 3.0Gb/s SATA drives becoming common in today's systems, serious players are pushing the envelope even further. (techspot.com)
Hard drives typically used in today's business applications offer 8MB of cache. (techspot.com)
The Greenville Drive are devastated by today's unprecedented announcement," stated Drive Owner and President, Craig Brown. (milb.com)

Over the last few years, Serial-ATA (SATA) technology has quickly replaced the earlier Parallel-ATA (PATA) specification as the preferred interface for high-performance hard drives. (techspot.com)

For other uses, see Hard drive (disambiguation) . (wikipedia.org)
List of screw drives, a screw drive Variable-frequency drive, a type of adjustable-speed drive Drive (charity), a campaign to collect items, usually other than money Driver (disambiguation) All pages with titles beginning with Drive All pages with titles containing Drive This disambiguation page lists articles associated with the title Drive. (wikipedia.org)

The shortage is not entirely bad news for the disk-drive business, especially for those companies whose facilities were not damaged, such as Seagate , which has a factory high and dry on a plateau in northeastern Thailand. (cnbc.com)
Nonetheless and despite this devasting news which impacts us on so many levels you can be sure that the Drive will remain as committed as ever investing in the economic health and vitality of our region and insuring the Upstate remains a wonderful place to live, work and raise a family. (milb.com)
Peter has contributed enormously to the station's achievements over the years, and as his current editor on Drive , I'm hugely grateful that he continues to play a big part in our news service. (bbc.co.uk)

London, 24 March 1999 (RFE/RL) -- The UN's World Health Organization (WHO) has launched a drive aimed at sharply reducing the incidence of malaria in Azerbaijan, and to prevent it from spreading to neighboring Caucasus and Central Asian countries. (rferl.org)

Noise is reduced in a disk drive enclosure by using vibration damping materials on the inside surface of the enclosure. (google.com)
These materials and their placement on the inside surface of the enclosure reduce noise without thermally insulating the disk drive. (google.com)
The connection between the disk drive and the external connector of the disk drive enclosure is made more reliable by using a printed circuit board instead of a cable. (google.com)
Also, errors in manufacturing of the disk drive enclosure can be reduced. (google.com)
To facilitate the use of the disk drive in a stripe set, the disk drive enclosure has a set of mechanical interlocks that permit the enclosures to be stacked vertically. (google.com)
The rack mount also may be provided with a quick-release mechanism that interacts with the mechanical interlocks to hold the disk drive enclosure in the rack mount. (google.com)
2. The disk drive enclosure of claim 1 , wherein the top portion has top face and the bottom portion has a bottom face such that the top face of the top portion of a first mechanical interlock supports the bottom face of the bottom portion of a second mechanical interlock when enclosures on which the first and second mechanical interlocks are attached are vertically aligned and stacked. (google.com)

On your computer, go to drive.google.com . (google.com)
You can use Google Drive on the web at drive.google.com . (google.com)

The use of pretty standard components apart from the lens and recording layer should make for a more affordable drive than InPhase's Tapestry drive which is priced around $12,000. (theregister.co.uk)
[2] These are calculated by constantly running samples of the drive for a short amount of time, analyzing the resultant wear and tear upon the physical components of the drive, and extrapolating to provide a reasonable estimate of its lifespan. (wikipedia.org)

These exhibit nearly all the warning signs of quackery , and Dr. Eisen doesn't provide any evidence beyond his own opinion and the usual unreliable miracle stories for his claim that he has a simple, safe, effective therapy that scientific medicine either doesn't know about or doesn't want you to know about. (skeptvet.com)

The Red Cross will conduct a Blood Drive at Caltech. (caltech.edu)
On Tuesday, September 24 the Red Cross Blood Drive will be held in the Winnett Lounge (above the Bookstore Bldg. #51 on the campus map)from 12pm - 6pm. (caltech.edu)
Wheaton VFW Post 2164 is hosting a blood drive on May 11 in honor of Armed Forces Day. (chicagotribune.com)
Please bring ID with you on the day of the blood drive. (chicagotribune.com)
The Harrisburg Senators are teaming up with the Central PA Blood Bank for a Blood Drive in the Senators home clubhouse at FNB Field on Friday, November 13 from 9am - 5pm. (milb.com)
Archie McPhee announces their 18th Annual Blood Drive and, of course, it's on Halloween. (seattlepi.com)

Apps will be unable to build until removing the Drive Android API dependency, but existing builds will be unaffected. (google.com)
Download apps from the Chrome Web Store to edit images and video, fax and sign documents, create flow charts, and more in Google Drive. (google.com)
After you add Google Drive apps from the Chrome Web Store, you can use them with Google Drive on the web. (google.com)
Not all Google Drive apps will be able to create files in Drive. (google.com)
Many Google Drive apps are made by companies that have their own terms of use and privacy policies. (google.com)
When you open files with Google Drive apps, some apps may ask permission to view some or all files in your Google Drive. (google.com)

Dr. Lorna Thorpe, Deputy Commissioner, Division of Epidemiology, NYC DOHMH discussed how New York City uses Federal data and uses models to apply to local level. (cdc.gov)

Flash memory has a growing share of the market for secondary storage, in the form of solid-state drives (SSDs). (wikipedia.org)
It enables background synchronization to ensure that the local Drive content mirrors the content in the remote project Share. (ibm.com)

we recommend using Storage Access Framework (SAF) which accesses the Drive Android app's content provider. (google.com)

Small files made up of a single stripe reside on a single drive while larger files - made up of several stripes - get divided among the various drives in the array. (techspot.com)

The problem is, the app asked me if I wanted to sync my drive. (linux.org)
All Drive Android API clients receive a local database with automated metadata sync for free. (google.com)

Your files in Drive can be reached from any smartphone, tablet, or computer. (google.com)
IBM® Aspera® Drive handles extremely large files and data sets easily-including entire directory structures. (ibm.com)
Aspera Drive combines authorization and access control for multilayered security, and provides security for data access and operations such as browsing, uploading, downloading, making new directories, renaming or deleting files and directories. (ibm.com)
Category for files regarding friction drives . (wikimedia.org)
To ease client migration efforts, a sample app has been provided which demonstrates how to create, modify, and query for a user's Drive files via the REST API. (google.com)
The sample app demonstrates how to create, modify, and query for Drive files using the REST API Java wrappers. (google.com)
if your application needs to read or modify Drive files that were not created by your application, you will need to enable a sensitive scope and submit your application to Google for review. (google.com)
Next up, you can now open, preview, and interact with Google Earth files (.kml and .kmz) right inside Google Drive on the Web. (thenextweb.com)
When you select files in your Drive list, in addition to adding them to an existing folder, you can add them directly to a new folder. (thenextweb.com)
In such cases, data files are divided and stored on each of the drives. (techspot.com)
With multiple drives simultaneously accessing the data files, performance is enhanced. (techspot.com)

VGrive is a client (back-end and front-end) for Google Drive made in Vala. (linux.org)
Earrings made from recycled computer hard drives connectors and beads. (etsy.com)
The programme was made by an independent producer, Made in Manchester Productions , so the Drive team takes no credit for this one. (bbc.co.uk)

These, in addition to platter damage, will quickly render a drive useless. (wikipedia.org)
For "certain" CD drives manufactured by LG, this command overwrites the firmware and renders the drive useless. (theregister.co.uk)

Dr. Cohn's lab site. (sickkids.ca)
I wasn't willing to support the promotion of this nonsense by buying the book, but Dr. Eisen does offer some glimpses of his ideas on his web site and in a number of free videos. (skeptvet.com)

With Drive Enterprise, businesses only pay for the storage employees use. (google.com)

Hard drive" redirects here. (wikipedia.org)
A hard disk drive ( HDD ), hard disk , hard drive or fixed disk [b] is a data storage device that uses magnetic storage to store and retrieve digital information using one or more rigid rapidly rotating disks ( platters ) coated with magnetic material. (wikipedia.org)
The hard disk drive was initially developed as data storage for the IBM 305 RAMAC computer system. (wikipedia.org)
A hard disk drive failure occurs when a hard disk drive malfunctions and the stored information cannot be accessed with a properly configured computer. (wikipedia.org)
Hard drives may also be rendered inoperable through data corruption , disruption or destruction of the hard drive's master boot record , or through malware deliberately destroying the disk's contents. (wikipedia.org)
Some hard disk drives simply fail because of worn out parts, [1] [ clarification needed ] others fail prematurely. (wikipedia.org)
Hard disk drive failures tend to follow the concept of the bathtub curve . (wikipedia.org)
Failure of a hard disk drive can be catastrophic or gradual. (wikipedia.org)
Gradual hard-drive failure can be harder to diagnose, because its symptoms, such as corrupted data and slowing down of the PC (caused by gradually failing areas of the hard drive requiring repeated read attempts before successful access), can be caused by many other computer issues, such as malware . (wikipedia.org)
A cyclical repetitive pattern of seek activity such as rapid or slower seek-to-end noises ( click of death ) can be indicative of hard drive problems. (wikipedia.org)
If you screw it up somehow, you still have a good bootable system on the hard drive. (faqs.org)
Now it's simple to not only view all of your cameras from one centralized application, but you can also record and playback video from your PC's hard drive. (google.com)
Seagate has introduced a new high-speed, eco-friendly hard drive for low-power personal computers. (pcworld.com)
Consumers worldwide could see increases of at least 10 percent in the price of external hard drives because of the flooding, according to Fang Zhang, an analyst at IHS iSuppli, a market research company. (cnbc.com)
The world's biggest names in hard-drive manufacturing, for example, operate from Thailand, where suppliers and customers come together. (cnbc.com)
Until the floodwaters came, a single facility in Bang Pa-In owned by Western Digital produced one-quarter of the world's supply of "sliders," an integral part of hard-disk drives. (cnbc.com)
He estimated it would take a full year for hard-drive production to return to preflood levels. (cnbc.com)
Make sure you also read our interview with Shiv Shivaji, Hitachi GST's Director for 3.5-inch (Hard Drive) Commercial and Consumer products , that was also posted today. (techspot.com)
Often Overlooked, the Hard Drive Plays a Critical Role in Overall Gaming System Capacity and Performance. (techspot.com)
But if you want a real edge in your next encounter, you must also give careful consideration to the hard drive and the hard drive configuration you employ. (techspot.com)
While often overlooked, the hard drive plays an important role in the system's overall capacity and performance which can be vital in ensuring a smooth-running, glitch-free experience. (techspot.com)
If data bogs down at the hard drive, you won't have a chance in Zanzibar to experience the full power of your system, no matter how much processing power you're packing. (techspot.com)
Hard drives can differ in capacity and performance. (techspot.com)
Over the last several years, advancements in technology have pushed the envelope in these two these areas and an understanding of each will help you chose the best hard drive for your needs. (techspot.com)
Over the last decade, the storage capacity for standard 3.5-inch hard drives has more than tripled in size. (techspot.com)
To reach maximum capacity, many gamers hook up multiple hard drives in a RAID configuration. (techspot.com)
The performance of a hard drive can also vary greatly from unit to unit. (techspot.com)
In order to take full advantage of fast seek times and cached data, the hard drive must deliver collected information as fast as possible and that's where the unit's interface technology takes over. (techspot.com)
Some cutting-edge hard drives on the market today offer another performance differentiator called Native Command Queuing (NCQ). (techspot.com)
This advancement allows the hard drive to automatically reorder requests for data in a manner that maximizes speed. (techspot.com)
In much the same way that RAM is essential in providing lightning-fast access to commonly used CPU data, hard drives use a cache system to speed up performance. (techspot.com)
And if you think he's good at asking the hard question on air, let me tell you that every Drive producer will be familiar with Peter approaching them about an upcoming interview to quiz them on their understanding of the story with a very direct: "Why are we doing this? (bbc.co.uk)

Check out the mental health treatment programs that have assisted Dr. Phil guests. (drphil.com)
Have a Story Dr. Phil Won't Believe? (drphil.com)
Want to appear on Dr. Phil? (drphil.com)

Prior to his career in teaching, Dr. Galit was a Chiropractor for almost 19 years, and was also a Brain research scientist at Rockefeller University in NYC for almost 2 years! (google.com)

The most notorious cause of drive failure is a head crash , where the internal read-and-write head of the device, usually just hovering above the surface, touches a platter , or scratches the magnetic data-storage surface. (wikipedia.org)
Clients who require access to Drive data will still be able to do so via the Drive REST API and its Java wrappers . (google.com)
Support for storing and syncing in the app data folder will likely be removed from Drive in the future. (google.com)
Clients requiring app data storage are strongly encouraged to migrate to a non-Drive solution such as Cloud Firestore . (google.com)
For user-visible data (e.g. that found in 'My Drive'), the REST API provides Java wrappers which seamlessly replicate the Android API's functionality. (google.com)
The existing documentation for these products is unaffected when used for Drive data obtained via the REST API. (google.com)
most Drive Android API clients which require an offline-first model are storing app data. (google.com)
App data support is likely to be removed from Drive in the future, and you should switch to a non-Drive solution (e.g. (google.com)
The 4K Advanced Format standard allows disk makers to not only pack more data on drives, but to support strong error correction. (pcworld.com)
The rate of data transfer to and from the drive and its data cache can all play an important role in the overall performance of your gaming system. (techspot.com)
Dr. Thomas Frieden, Commissioner of the NYC DOHMH discussed how New York City uses epidemiological data for public health action within the City. (cdc.gov)
Discussion with Dr. Frieden -- Dr. Frieden said he wished he could access more data from the clinical system and lamented the barriers to data sharing, specifically his frustration with the lack of Medicaid data. (cdc.gov)
ASUS internal DVD drives provide you with flexible and efficient multimedia data access and storage, plus M-DISC™ support to save your precious memories for a millennium. (asus.com)

The Iomega ZIP drive is a popular, removable media disk drive. (faqs.org)
Because a printed circuit board has a fixed location and fixed layout, variability among disk drive enclosures can be minimized. (google.com)

Drive manufacturers typically specify a mean time between failures (MTBF) or an annualized failure rate (AFR) which are population statistics that can not predict the behavior of an individual unit. (wikipedia.org)

[3] Drives typically fail within a short time if there is a defect present from manufacturing. (wikipedia.org)
The former typically presents as a drive that can no longer be detected by CMOS setup , or that fails to pass BIOS POST so that the operating system never sees it. (wikipedia.org)
Though most drivers typically have some understanding of the capabilities of ADAS technology, most don't grasp the systems' limitations, says Dr. Eddy Llaneras, the principal investigator for VTTI on the study. (wired.com)

Key features in Google Drive were conceptualized and developed in India, a feather in the hat of India's capabilities in software development story. (zdnet.com)
Google Drive has three paid tiers and the Billing Systems for this have been done India. (zdnet.com)
1. A brief biographical sketch of Dr. Shriniwas Kashalikar Early childhood: Dr. Shriniwas Janardan Kashalikar was born on March 4, 1951 in Savantwadi (district: Sindhudurga) of Maharashtra state in India. (slideshare.net)

If either the drive or the media is dirty, users may experience the buzz of death when attempting to access the drive. (wikipedia.org)
If you do this, be sure to load scsi.o, then sd.o and finally the driver for your host adapter, before you try to access the ZIP drive. (faqs.org)
Clients must configure their app to request access to the Drive API in the Google Cloud Console similarly to the existing Drive Android API authentication process. (google.com)
For most projects with Drive Android API access enabled, no changes will be required to your existing project configuration. (google.com)
Windows only: Free application DropboxPortable makes the popular file-syncing application thumb-drive friendly, so you can access your synced bucket from your thumb drive no matter what computer you're using. (lifehacker.com)

The hypothalamus is the brain area responsible for releasing hormones that regulate a variety of bodily functions, including body temperature, appetite, sex drive, thirst, sleep, and mood. (medicalnewstoday.com)

A drive also includes controller electronics, which occasionally fail. (wikipedia.org)
If you already have a SCSI disk in your system, and you are connecting the ZIP drive to the same controller, there is no additional kernel configuration required. (faqs.org)

Understanding Nichia is simple: it co-developed blue-violet laser diodes in conjunction with Sony and they are used in Blu-ray drives. (theregister.co.uk)

Drive platters are coated with an extremely thin layer of non- electrostatic lubricant, so that the read-and-write head will simply glance off the surface of the platter should a collision occur. (wikipedia.org)

The Blog system gives you your own personal space at Dynamic Drive Forums. (dynamicdrive.com)
To use the ZIP drive with Linux, you must have a kernel configured with support for the SCSI system, support for SCSI disks, and support for the host adapter you are using. (faqs.org)
Apple today unveiled a new cloud-based storage system called iCloud Drive. (thenextweb.com)

Outside of his medical practice, Dr. Jenson Mak is the Convenor of the 2012 ACMA Gala Dinner with 250+ attendants at Crystal Palace Sydney (Raised in excess of AUD$25000 for 2 organizations delivering services for children with disabilities - Northcott and Woodbury). (behance.net)
After plenty of practice, give your teen a chance to drive with more passengers in the car. (kidshealth.org)

Dr. Michael Frankel is professor of neurology, Emory University School of Medicine, and chief of neurology and director of the Marcus Stroke and Neuroscience Center at Grady Memorial Hospital. (emory.edu)
Dr. Jimmy Kildare is back at work at Blair General hospital, though several people admit that he is not himself since suffering his loss. (imdb.com)
Dr. James Kildare has just completed his internship at Blair General Hospital and is assigned to work with his mentor, Dr. Leonard Gillespie. (imdb.com)

Dr. Keller promotes the concept of one patient focus per day to provide the one on one care that his patients deserve. (regrowhair.com)
The Drive and its West End Events team have taken the "Greater Greenville Pledge" and are continuing to implement best-practices for cleanliness and sanitization of the park, including continuing to add health and safety measures that will provide all Fluor Field visitors with the safest and healthiest experience possible. (milb.com)

After passing Trece Martires, Governor's Drive continues westward on a slightly winding route toward Naic. (wikipedia.org)

Both biological and psychological factors strongly influence sexual drive. (sparknotes.com)

Dr. Galit has also been teaching at local colleges for the past 14 years (Anatomy and physiology, Microbiology, and also General Biology)! (google.com)
A coalition of Michigan education groups has launched a petition drive to pressure the legislature to vote on a guaranteed annual funding increase for schools and colleges. (edweek.org)

Dr. Richard Keller completed his General Surgery training at University of Illinois and has been a practicing physician for over 20 years. (regrowhair.com)
Therefore, even if a drive is subjected to several years of heavy daily use, it may not show any notable signs of wear unless closely inspected. (wikipedia.org)
This is Dr. Galit's 13th year in public education, having taught 11 years at Maiden Middle School, and now this is his second year at Grandview! (google.com)
Dr. Margaret Rutherford is a clinical psychologist who has been practicing for over 20 years in Fayetteville, Arkansas. (huffingtonpost.com)
The official party line on the anticorruption campaign, spelled out in a People's Daily commentary April 22, is that the drive "to rectify the party's work style" would continue for two more years. (washingtonpost.com)
Dr. Fredrik Hiebert, archaeologist and curator, has traced ancient trade routes overland and across the seas for more than 20 years. (nga.gov)

Anatomy45

Organisms15

Diseases8

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Psychiatry and Psychology9

Phenomena and Processes109

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena3

Information Science7

Health Care6

Drug addiction as drive satisfaction ("antidrive") dysfunction. (1/52)

Bradykinin stimulates respiratory drive by activating pulmonary sympathetic afferents in the rabbit. (2/52)

Reward processing in the brain: a prerequisite for movement preparation? (3/52)

The differential effect of conation on intelligence test scores among brain-damaged and control subjects. (4/52)

Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinness. (5/52)

Role of voluntary drive in encoding an elementary motor memory. (6/52)

The etymology of basic concepts in the experimental analysis of behavior. (7/52)

Perception of the consequences of self-action is temporally tuned and event driven. (8/52)

Drive

Models, Biological

Signal Transduction

Molecular Sequence Data

Promoter Regions, Genetic

Mice, Transgenic

Respiration

Mutation

Mice, Inbred C57BL

Base Sequence

Neurons

Motor Neurons

Animals, Genetically Modified

Electromyography

Gene Expression Regulation, Developmental

Action Potentials

Cells, Cultured

Transcription Factors

Time Factors

Green Fluorescent Proteins

Gene Expression Regulation

Cell Differentiation

Mice, Knockout

Respiratory Mechanics

Biological Evolution

Sex Ratio

Protein Binding

Drosophila Proteins

Respiratory Center

Genes, Reporter

Transgenes

Periodicity

Meiosis

Cell Proliferation

Inhalation

Licensure

Biological Clocks

Drosophila melanogaster

Cell Line, Tumor

Selection, Genetic

Amino Acid Sequence

Cell Line

Protein Structure, Tertiary

Drosophila

Phrenic Nerve

Transcription, Genetic

Hypoglossal Nerve

Models, Genetic

Evolution, Molecular

Cell Movement

Embryo, Nonmammalian

Carbon Dioxide

Models, Molecular

Electric Stimulation

Respiratory Muscles

Hypercapnia

Zebrafish

Apnea

Computer Simulation

Binding Sites

Muscle, Skeletal

Phenotype

Ecosystem

DNA-Binding Proteins

Disease Models, Animal

Membrane Proteins

Movement

Neural Pathways

Feedback, Physiological

Recombinant Fusion Proteins

Models, Neurological

Brain Stem

Interneurons

Rats, Sprague-Dawley

Molecular Motor Proteins

Neural Inhibition

RNA, Messenger

Synapses

Nerve Net

Synaptic Transmission