HLA-DR3 Antigen: An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles.HLA-DR Antigens: A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.HLA-DR4 Antigen: An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.Histocompatibility Antigens Class II: Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.Antigens: Substances that are recognized by the immune system and induce an immune reaction.HLA-DR Serological Subtypes: HLA-DR antigen subtypes that have been classified according to their affinity to specific ANTIBODIES. The DNA sequence analyses of HLA-DR ALPHA-CHAINS and HLA-DR BETA-CHAINS has for the most part revealed the specific alleles that are responsible for each serological subtype.HLA-D Antigens: Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.Histocompatibility Testing: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)Genes, MHC Class II: Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and in the I region in mice.HLA-B Antigens: Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.HLA-DQ Antigens: A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.HLA-DRB1 Chains: A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.HLA-DR2 Antigen: A broad specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*01:15 and DRB1*01:16 alleles.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Lymphocyte Culture Test, Mixed: Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.HLA-DR7 Antigen: A HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*07 alleles.HLA-DQ beta-Chains: Transmembrane proteins that form the beta subunits of the HLA-DQ antigens.HLA-DR1 Antigen: An HLA-DR antigen associated with HLA-DRB1 CHAINS that are encoded by DRB1*01 alleles.Keratoconjunctivitis Sicca: Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Gold Sodium Thiomalate: A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.Epitopes: Sites on an antigen that interact with specific antibodies.HLA-A Antigens: Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.Antigens, Protozoan: Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.Antigens, Polyomavirus Transforming: Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.Haplotypes: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Antigens, Fungal: Substances of fungal origin that have antigenic activity.Epitopes, T-Lymphocyte: Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Antigens, Helminth: Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.H-2 Antigens: The major group of transplantation antigens in the mouse.Dichlororibofuranosylbenzimidazole: An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.HLA-DRB3 Chains: A subtype of HLA-DRB beta chains that includes over 50 allelic variants. The HLA-DRB3 beta-chain subtype is associated with HLA-DR52 serological subtype.Histocompatibility Antigens Class I: Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Antigens, Viral, Tumor: Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.Histocompatibility Antigens: A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.Receptors, Antigen, T-Cell: Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.HLA-A2 Antigen: A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Proliferating Cell Nuclear Antigen: Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.HLA-DRB4 Chains: A subtype of HLA-DRB beta chains that is associated with the HLA-DR53 serological subtype.Receptors, Antigen, B-Cell: IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.Prostate-Specific Antigen: A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.O Antigens: The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)HLA-C Antigens: Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).HLA-DRB5 Chains: A subtype of HLA-DRB beta chains that is associated with the HLA-DR51 serological subtype.Dipeptidyl Peptidase 4: A serine protease that catalyses the release of an N-terminal dipeptide. Several biologically-active peptides have been identified as dipeptidyl peptidase 4 substrates including INCRETINS; NEUROPEPTIDES; and CHEMOKINES. The protein is also found bound to ADENOSINE DEAMINASE on the T-CELL surface and is believed to play a role in T-cell activation.Antigens, CD8: Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Antigens, CD15: A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Antigens, Tumor-Associated, Carbohydrate: Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.HLA-DP beta-Chains: Transmembrane proteins that form the beta subunits of the HLA-DP antigens.Blood Group Antigens: Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.Antigens, CD3: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).Hepatitis B Surface Antigens: Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Mice, Inbred BALB CMajor Histocompatibility Complex: The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.DNA Probes, HLA: DNA probes specific for the human leukocyte antigen genes, which represent the major histocompatibility determinants in humans. The four known loci are designated as A, B, C, and D. Specific antigens are identified by a locus notation and number, e.g., HLA-A11. The inheritance of certain HLA alleles is associated with increased risk for certain diseases (e.g., insulin-dependent diabetes mellitus).Gene Frequency: The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.Antigens, CD4: 55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Antigens, CD45: High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Receptors, Antigen: Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Antigen-Antibody Reactions: The processes triggered by interactions of ANTIBODIES with their ANTIGENS.Hepatitis B Antigens: Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.T-Lymphocytes, Cytotoxic: Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.Antigens, CD1: Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.HLA-B44 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*44 allele family.Immune Sera: Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).HLA-A1 Antigen: A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*01 allele family.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Antigens, Differentiation: Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Antigens, Differentiation, T-Lymphocyte: Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.HLA-B7 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*07 allele family.HLA-B27 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.HLA-B8 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*08 allele family.Genes, MHC Class I: Genetic loci in the vertebrate major histocompatibility complex which encode polymorphic characteristics not related to immune responsiveness or complement activity, e.g., B loci (chicken), DLA (dog), GPLA (guinea pig), H-2 (mouse), RT-1 (rat), HLA-A, -B, and -C class I genes of man.HLA-DR5 Antigen: A broad-specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*11 and DRB1*12 alleles.
"Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps". Ann. Otol. Rhinol. Laryngol. ... Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (2006). "Association of HLA-DRB1*0901-DQB1*0303 haplotype with ... HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 ... Törn C, Gupta M, Sanjeevi CB, Aberg A, Frid A, Landin-Olsson M (2004). "Different HLA-DR-DQ and MHC class I chain-related gene ...
... (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of ... "HLA-DR antigens in pemphigus among Japanese". Tissue Antigens. 17 (2): 238-9. doi:10.1111/j.1399-0039.1981.tb00689.x. PMID ... derived from IMGT/HLA Roudier J (2006). "HLA-DRB1 genes and extraarticular rheumatoid arthritis". Arthritis Research & Therapy ... "HLA-DR specificities among Japanese with several autoimmune diseases". Tissue Antigens. 19 (2): 129-33. doi:10.1111/j.1399- ...
Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival ... The HLA-DRB4 locus encodes the HLA-DR53 specificity, has some variation, and is associated with certain HLA-DRB1 types. The HLA ... and at the HLA-DRB1 locus to a greater degree relative to HLA-DQB1 and HLA-DPB1. Most of the HLA alleles currently present in ... The complex of HLA-DR (Human Leukocyte Antigen - antigen D Related) and its ligand, a peptide of 9 amino acids in length or ...
"Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... "HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations". Tissue Antigens. 59 (5): 397-406. doi:10.1034/j.1399- ... HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 ... "HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity". Tissue Antigens ...
HLA class II histocompatibility antigen, DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene. HLA-DRA ... Thus there is the potential that any given individual can form 4 different HLA-DR isoforms (2 alleles of DRB1 and two alleles ... There are two different HLA-DRA chains in the human population coded by three different DRA alleles: HLA-DR ENSG00000206308, ... "Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain". Nucleic Acids Res ...
... leprosy HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups. HLA-DR2 HLA-DR15 - DRB1*15 HLA-DR16 ... HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5. DRB3, DRB4, and DRB5 are ... "Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 ... Gongora R, Figueroa F, Klein J (1996). "The HLA-DRB9 gene and the origin of HLA-DR haplotypes". Hum. Immunol. 51 (1): 23-31. ...
... (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA ... This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups. DR2 serotypes are associated ... DR2 is linked to the HLA-DR51. derived from IMGT/HLA Stewart G, McLeod J, Basten A, Bashir H (1981). "HLA family studies and ... Miyamori H, Kato Y, Kobayashi K, Hattori N (1983). "HLA antigens in Japanese patients with primary biliary cirrhosis and ...
Wang JF, Zhang D, Zhao JZ, Jia BX, Bi RM (2006). "A study on the relationship between HLA-DR, DQ antigen, and intracranial ... MuSK antibody-positive myasthenia gravis HLA-DR14-DQ5, probably DRB1*1402 : DQA1*0104 : DQB1*0503 (DR14-DQ5). DR1-DQ5 is ... HLA-DQ5 (DQ5) is a human leukocyte antigen serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the ... HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA ...
"HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and ... Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D (1995). "Association of HLA-DR5 (possibly DRB1*1201 ... HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes. With the ... "Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles". Arch Dermatol. 123 (9): 1188-91. doi: ...
Hirsch TJ, Enlow RW, Bias WB, Arnett FC (October 1981). "HLA-D related (DR) antigens in various kinds of myositis". Hum. ... "Meta-analysis of HLA-DRB1 and HLA-DQB1 polymorphisms in Latin American patients with systemic lupus erythematosus". Autoimmun ... Prior to refined typing for HLA-DQ and DR, the association with HLA-A1 and B8 was identified for coeliac disease in 1973 and ... "Correlation between acetylcholine receptor antibody titer and HLA-B8 and HLA-DRw3 antigens in myasthenia gravis". Trans Am ...
... (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA- ... "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". ... DQB1*0301 haplotype is associated with hepatitis B virus persistence HLA-DR11 is genetically linked to HLA-DR52 and HLA-DQ7(3) ... Chou HT, Chen CH, Chen JY, Chang KC (2007). "Association of HLA DRB1-DQA1-DQB1 haplotypes with rheumatic heart disease in ...
"HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity". Tissue Antigens ... HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. ... Jönsen A, Bengtsson A, Sturfelt G, Truedsson L (2004). "Analysis of HLA DR, HLA DQ, C4A, FcgammaRIIa, FcgammaRIIIa, MBL, and IL ... HLA-DR3-DQ2 is found in HLA A1-B8-DR3-DQ2 haplotype in Northern Europeans (including the British Ilse, Ireland, Iceland). HLA ...
... (DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the ... "The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/ ... colorectal cancer HLA-DR12 is genetically linked to DR52 and HLA-DQ7 serotypes. derived from IMGT/HLA DR8 - 2% Gao X, Barnardo ... Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. ...
... (DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the ... DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens. DR16 is associated with ... "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". ... HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes. derived from IMGT/HLA Cruz-Robles D, Reyes P, Monteón-Padilla ...
... (DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 ... serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens. Serotypes ... HLA-DR13 is genetically linked to HLA-DR52 and HLA-DQ5 (HLA-DQ1) serotypes. derived from IMGT/HLA DR1404 - 3% DR4 - 25% ... "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". ...
... (DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 ... serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens. Serotypes ... DRB1*1302:DQA1*0102:DQB1*0604 Early childhood myastenia gravis HLA-DR13 is genetically linked to DR52 and HLA-DQ6 (HLA-DQ1) ... Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. ...
... (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high ... DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens. Serotypes are unknown the ... "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". ... DQB1*0501 haplotype is associated with systemic lupus erythematosus HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA ...
Müller CR, Ehninger G, Goldmann SF (January 2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based ... HLA class II typing (HLA-DRB1, DQA1, and DQB1) of Sardinians revealed that they fell outside of the European cluster and tended ... March 2000). "HLA genes in Arabic-speaking Moroccans: close relatedness to Berbers and Iberians". Tissue Antigens. 55 (3): 239- ... 1997). "Distribution of HLA-A, B and DR genes and haplotypes in the Irish population". Exp. Clin. Immunogenet. 14 (4): 250-63. ...
Pollack MS, Gold J, Metroka CE, Safai B, Dupont B (1984). "HLA-A,B,C and DR antigen frequencies in acquired immunodeficiency ... It is also associated with Membranous glomerularnephritis DRB1*0301 (see HLA-DR17) DRB1*0302 (See HLA-DR18) DRB1*0304 is ... HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 ... Type 1 diabetes mellitus is strongly associated with HLA-DR3 or HLA-DR4. Some DR3 also react with HLA-DR17 and/or HLA-DR18. The ...
HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 ... HLA-DRB1 major histocompatibility complex, class II, DR beta 1". Gregersen PK, Silver J, Winchester RJ (Nov 1987). "The shared ... encodes the most prevalent beta subunit of HLA-DR. Several alleles of DRB1 (shared epitope alleles) are associated with an ... DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and ...
... (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. The serology for the most commom DR1 alleles is ... "HLA-DR antigens in rheumatoid arthritis. A Swiss collaborative study; final report. Swiss Federal Commission for the Rheumatic ... "Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome". ... 2005). "HLA-DRB1 alleles and Jk(a) immunization". Transfusion. 45 (6): 956-959. doi:10.1111/j.1537-2995.2005.04366.x. PMID ...
... (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in ... DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18. DR17 recognizes the DRB1*0301, * ... These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles. DRB1*0301 is ... The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome HLA-DR17 is genetically linked to DR52 and HLA-DQ2 ...
1994). "HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method". Tissue Antigens. ... HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain ... Olerup O, Olsson R, Hultcrantz R, Broome U (1995). "HLA-DR and HLA-DQ are not markers for rapid disease progression in primary ... 1992). "Association of HLA-B51 and lack of association of class II alleles with Behçet's disease". Tissue Antigens. 40 (1): 22- ...
DRB1*07 HLA-DR9 - DRB1*09 Gorski J, Rollini P, Mach B (1987). "Structural comparison of the genes of two HLA-DR supertypic ... Morita K, Moriuchi J, Inoko H, Tsuji K, Arimori S (1991). "HLA class II antigens and DNA restriction fragment length ... HLA-DR53 serotypes (HLA-DRB4) is linked to the following HLADR serotypes (HLA-DRB1) allele groups: HLA-DR4 - DRB1*04 HLA-DR7 - ... HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode ...
Gorski J, Mach B (1986). "Polymorphism of human Ia antigens: gene conversion between two DR beta loci results in a new HLA-D/DR ... DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and ... HLA-DR "Human PubMed Reference:". "Entrez Gene: HLA-DRB3 major histocompatibility complex, class II, DR beta 3". Germain RN ( ... HLA class II histocompatibility antigen, DRB3-1 beta chain is a protein that in humans is encoded by the HLA-DRB3 gene. The ...
... -3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA-Cw, HLA-DRB1 ... They are HLA-A, HLA-B, (both Class I MHCs) and HLA-DR (a Class II MHC).[5] If the two tissues have the same genes coding for ... HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system ... In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I. ...
... and to investigate the possible association of HLA-DRB1 alleles with disease severity in LN. HLA-DRB1 alleles were studied in ... HLA)-DRB1 alleles with systemic lupus erythematosus (SLE) and lupus nephritis (LN) in the Taiwanese population, ... To evaluate the association of human leukocyte antigen ( ... HLA-DR Antigens / genetics* * HLA-DR Antigens / immunology * ... and to investigate the possible association of HLA-DRB1 alleles with disease severity in LN. HLA-DRB1 alleles were studied in ...
We investigated, using data from 38 studies, whether the DR-DQ haplotypes and gen … ... The direct involvement of the human leukocyte antigen class II DR-DQ genes in type 1 diabetes (T1D) is well established, and ... The direct involvement of the human leukocyte antigen class II DR-DQ genes in type 1 diabetes (T1D) is well established, and ... with DRB1*0301 DQB1*0200 (DR3) being significantly less predisposing than DRB1*0402 and more than DRB1*0404. The predisposing ...
The HLA-DRB1 gene provides instructions for making a protein that plays a critical role in the immune system. Learn about this ... which is produced from the HLA-DRA gene. Together, they form a functional protein complex called the HLA-DR antigen-binding ... The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the ... medlineplus.gov/genetics/gene/hla-drb1/ HLA-DRB1 gene. major histocompatibility complex, class II, DR beta 1 ...
HLA class II histocompatibility antigen, DR alpha chain. *HLA class II histocompatibility antigen, DRB1-1 beta chain. *T-cell ... HLA class II histocompatibility antigen, DR alpha chain. *HLA class II histocompatibility antigen, DRB1-1 beta chain. *T-cell ... HLA class II histocompatibility antigen, DR alpha chain. *HLA class II histocompatibility antigen, DRB1-1 beta chain. *T-cell ... HLA class II histocompatibility antigen, DR alpha chain. *HLA class II histocompatibility antigen, DRB1-1 beta chain. *T-cell ...
... which is produced from the HLA-DRA gene. Together, they form a functional protein complex called the HLA-DR antigen-binding ... The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the ... A particular HLA-DRB1 gene variant called HLA-DRB1*04:04 is the most well-known risk factor for autoimmune Addison disease. ... It is not clear how HLA-DRB1*04:04 and other HLA-DRB1 variations are involved in the inappropriate immune response that causes ...
We studied the relationship between maternal-fetal HLA disparity and IBD course. METHODS: Women with IBD and childbirth wer ... 0/HLA-DQ Antigens; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen ... HLA-DQ Antigens / analysis*. HLA-DR Antigens / analysis*. Humans. Pregnancy. Pregnancy Complications / immunology*, ... Each mother/child pair was assigned an HLA disparity status (+/-) for HLA A, B, C, DRB1, and DQ loci. Odds ratios were ...
The phenotype frequency of DRB1*15 in the patients was significantly higher (0.316 vs. 0.112; p(c),10(-6); Odds Ratio (OR)=3.64 ... The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. ... 0/HLA Antigens; 0/HLA-DR Antigens; 0/HLA-DR15; 0/Histocompatibility Antigens Class I; 128338-86-3/HLA-DRB1 antigen ... HLA Antigens / analysis, genetics*. HLA-DR Antigens / analysis, genetics. Histocompatibility Antigens Class I / genetics. ...
Mouse monoclonal HLA Class II DRB1 antibody [TDR 31.1]. Validated in ELISA, RIA, Flow Cyt and tested in Human. Cited in 2 ... HLA class II histocompatibility antigen, DR-1 beta chain antibody. *HLA class II histocompatibility antigen, DRB1-15 beta chain ... Anti-HLA Class II DRB1 antibody [TDR 31.1]. See all HLA Class II DRB1 primary antibodies. ... Demonstration of two distinct light chains in HLA-DR-associated antigens by two-dimensional gel electrophoresis.. Eur J Immunol ...
Alleles, Base Sequence, DNA Primers, HLA-DR Antigens/*genetics, Humans, Microsatellite Repeats/*genetics, Polymorphism; Genetic ... We analyzed the origin of allelic diversity at the class II HLA-DRB1 locus, using a complex microsatellite located in intron 2 ... Tracing the origin of HLA-DRB1 alleles by microsatellite polymorphism.. Bergström, Tomas Uppsala universitet, Medicinska ... In all contemporary DRB1 allelic lineages, with the exception of the human *04 and the gorilla *08 lineages, the (GA)y repeat ...
... leprosy HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups. HLA-DR2 HLA-DR15 - DRB1*15 HLA-DR16 ... HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5. DRB3, DRB4, and DRB5 are ... "Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 ... Gongora R, Figueroa F, Klein J (1996). "The HLA-DRB9 gene and the origin of HLA-DR haplotypes". Hum. Immunol. 51 (1): 23-31. ...
"Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... "HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations". Tissue Antigens. 59 (5): 397-406. doi:10.1034/j.1399- ... HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 ... "HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity". Tissue Antigens ...
Mouse monoclonal Ovine MHC Class II DR antibody [37.68] validated for IP, IHC, Flow Cyt and tested in Human, Shp, Goat and Cow ... HLA class II histocompatibility antigen antibody. *HLA DRA antibody. *HLA DRB1 antibody ... Class-II-positive cells (antigen-presenting cells) can take up antigens from outside by endocytosis, degrade them into small ... Several class II antigens are also associated with disease states. The extremely high polymorphism of MHC class II ...
Related donor matched at 5 or 6 HLA antigens (A, B, DR). - Unrelated donor fully matched by molecular analysis at A, B, DRB1, ... Single antigen mismatch at C allowed. - Cord blood that is 4, 5, or 6 match with recipient HLA antigens (A, B, DR) NOTE:. No ...
HLA-DR Antigens. en. dc.subject. HLA-DRB1 Chains. en. dc.subject. Humans. en. ... Adult human leukocyte antigen (HLA)-matched MSC have been used in cellular therapies of bone disorders such as osteogenesis ...
MHC class II antigen (Fragment). GORGO. 80. MHC class II DR beta (Fragment). western gorilla ... tr,I6M557,I6M557_HUMAN MHC class II antigen (Fragment) OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=4 SV=1 ... MHC class II antigenImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>, ...
Shop a large selection of products and learn more about HLA-DR Mouse anti-Human, FITC, Clone: LN3, eBioscience :: 25 Tests; ... HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, ... Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney ... HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial ...
13] This was associated with a human leukocyte antigen (HLA)-DR restriction, and with increased frequency of HLA-DRB1*13 and ... Mold-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ. Allergy. 2010 Nov. 65(11):1367- ... HLA-DRB1*03. A decreased frequency of HLA-DQB1*03 was noted in Alternaria -sensitive moderate-to-severe asthma, suggesting HLA- ...
HLA-DRB1, Human Leukocyte Antigen - Major Histocompatibility Complex, Class II, DR beta 1 gene; IL-6, Interleukin-6 gene; IL-8 ... Payen and colleagues [49] found an association between the presence of 4 human leukocyte antigen-DR-beta (HLA-DRB) alleles and ... A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA ...
HLA) region located on the short arm...For many years HLA polymorphisms were typed by serological respons...,The,Past,,Present, ... and,Future,of,HLA,Typing,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest ... there appear to be 300+ alleles in the HLA-B or DRB1 loci. A clear understanding of the differences between HLA polymorphisms ... are expressed by the HLA DR, -DQ and DP loci. Each locus is highly polymorphic; for example, ...
HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-1 BETA CHAIN. B. 190. Homo sapiens. Mutation(s): 0 Gene Names: HLA-DRB1. ... SEH interacts with high affinity through a zinc ion with the beta1 chain of HLA-DR1 and also with the peptide presented by HLA- ... HLA-DR1) has been determined by X-ray crystallography to 2.6 A resolution (1HXY). The superantigen binds on top of HLA-DR1 in a ... HLA-DR1) has been determined by X-ray crystallography to 2.6 A resolution (1HXY). ... ...
HLA-DR Monoclonal Antibody, Qdot® 655 conjugate from Invitrogen for Flow Cytometry applications. This antibody reacts with ... histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen, DR ... Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney ... Cite HLA-DR Monoclonal Antibody (Tü36), Qdot 655. The following antibody was used in this experiment: HLA-DR Monoclonal ...
Mouse Monoclonal Anti-HLA DRB1 Antibody (DA2) [DyLight 488]. Validated: WB, ELISA, Flow, IHC, IHC-Fr. Tested Reactivity: Human ... HLA class II antigen beta chain. *HLA class II histocompatibility antigen, DR-1 beta chain ... Home » HLA DRB1 » HLA DRB1 Antibodies » HLA DRB1 Antibody (DA2) [DyLight 488] ... Reviews for HLA DRB1 Antibody (NB100-2705G) (0) There are no reviews for HLA DRB1 Antibody (NB100-2705G). By submitting a ...
INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS II MOLECULE, HLA-DR1 ... HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-1 BETA CHAIN. B. ... Gene Names: HLA-DRB1. Find proteins for P01911 (Homo sapiens). Go to Gene View: HLA-DRB1 ... TCR gene usage in the response to HA/HLA-DR appears to conserve charged interactions between three lysines of the peptide and ... An alphabeta T-cell receptor (alphabetaTCR)/hemagglutinin (HA) peptide/human leukocyte antigen (HLA)-DR1 complex was stabilized ...
Genotyping of HLA-DRB1 alleles was performed by polymerase chain reaction and hybridization with sequence-specific ... Thirty percent of RA patients were carrying at least one copy of the HLA-DRB1 shared epitope (SE) compared to 10% and 14% of ... and to determine the prevalence of HLA-DRB1 shared epitope alleles (SE) in African patients with rheumatoid arthritis (RA). ... These studies included a limited number of patients and mainly referred to HLA-DR antigens detected by serological typing or by ...
Keywords: Alleles, Animals, Evolution, Molecular, HLA-DR Antigens, HLA-DRB1 Chains, Humans, Phylogeny, Polymorphism, Genetic, ... for most of the alleles at the HLA-DRB1 locus. Sites encoding for amino acids involved in antigen binding [antigen recognizing ... The HLA region harbors some of the most polymorphic loci in the human genome. Among them is the class II locus HLA-DRB1, with ... HLA-DRB1*11 (major histocompatibility complex, class II, DR beta 1 allele 11 ) ...
  • DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. (fishersci.com)
  • Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. (fishersci.com)
  • TCR gene usage in the response to HA/HLA-DR appears to conserve charged interactions between three lysines of the peptide and acidic residues on the TCR. (rcsb.org)
  • SEH interacts with high affinity through a zinc ion with the beta1 chain of HLA-DR1 and also with the peptide presented by HLA-DR1. (rcsb.org)
  • An effective and effecient peptide binding prediction approach for a broad set of HLA-DR molecules based on ordered weighted averaging of binding pocket profiles. (ebi.ac.uk)
  • We then established peptide-specific T-cell clones for five of these six peptides and demonstrated that the T-cell clone specific for the PSMA 459 epitope (NYTLRVDCTPLMYSL) can recognize processed antigens from recombinant PSMA proteins. (aacrjournals.org)
  • These peptide epitopes bind to HLA-class II molecules, and subsequently the complex of HLA-class II and TSHR-ECD epitope is presented to CD4+ T cells. (frontiersin.org)
  • TSHR peptide epitopes bound to HLA-class II are presented by antigen-presenting cells (APCs) to CD4+ T cells (Figure 2 ). (frontiersin.org)
  • Anticitrullinated peptide antibody-positive rheumatoid arthritis (RA) in Indigenous North American populations was independently associated with HLA-DRB1 *14:02. (antibodies-online.com)
  • The identification of class II binding peptide epitopes from autoimmune disease-related antigens is an essential step in the development of antigen-specific immune modulation therapy. (ox.ac.uk)
  • The presentation of these two T cell epitopes in the islets of DRB1*0401 individuals who are at risk for type 1 diabetes may allow for antigen-specific recruitment of regulatory cells to the islets following peptide immunization. (ox.ac.uk)
  • With JIA-OP, we identified a set of single AA SFs, and SFs in which they occur, particularly pockets of the peptide binding site, that account for the major disease risk attributable to HLA DRB1. (pubmedcentralcanada.ca)
  • Disclosed herein is a reductionistic system incorporating known participants of MHC class II antigen processing in solution to generate peptide pools from antigens, including those for which no immunodominant epitope has yet been identified, that are highly enriched for proteolytic fragments containing their immunodominant epitopes. (freepatentsonline.com)
  • Editing of the HLA-DR-peptide repertoire by HLA-DM," The EMBO Journal, 15(22):6144-6154 (1996). (freepatentsonline.com)
  • Persistent central memory phenotype of circulating Fel d 1 peptide/DRB1*0101 tetramer-binding CD4+ T cells. (ox.ac.uk)
  • HLA-peptide-tetrameric complexes allow the tracking of antigen-specific T-cell populations based on the presence of specific T-cell receptors and when combined with functional assays allow a closer assessment of the potential roles of T-cell anergy and clonotype evolution. (ox.ac.uk)
  • Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). (abcam.co.jp)
  • The HLA-DRB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
  • The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
  • The protein produced from the HLA-DRB1 gene, called the beta chain, attaches (binds) to another protein called the alpha chain, which is produced from the HLA-DRA gene. (medlineplus.gov)
  • Researchers have identified hundreds of different versions (alleles) of the HLA-DRB1 gene, each of which is given a particular number (such as HLA-DRB1 *04:01). (medlineplus.gov)
  • Certain variations in the HLA-DRB1 gene have been linked to an increased risk of developing an autoimmune disorder called autoimmune Addison disease. (medlineplus.gov)
  • A particular HLA-DRB1 gene variant called HLA-DRB1*04:04 is the most well-known risk factor for autoimmune Addison disease. (medlineplus.gov)
  • Variations in the HLA-DRB1 gene have been associated with an increased risk of developing multiple sclerosis. (medlineplus.gov)
  • One variant of this gene, called HLA-DRB1*15:01 , is the most strongly linked genetic factor for the risk of multiple sclerosis. (medlineplus.gov)
  • Because the HLA-DRB1 gene is involved in the immune system, changes in it might be related to the autoimmune response and inflammation that damage nerves and the protective coating surrounding them (the myelin sheath), leading to the signs and symptoms of multiple sclerosis. (nih.gov)
  • HLA-DRB1*15, low infant sibling exposure, and multiple sclerosis gene-environment interaction. (ox.ac.uk)
  • The HLA DRB1 gene analysis showed increase of DRB1*07 in aplastic anaemia patients compared to normal population (P = 0.02). (cdc.gov)
  • For all patients with RA recruited to the study, HLA-DR beta1 gene status was recorded as was the erythrocyte sedimentation rate (ESR) at the first ever clinic visit. (uws.ac.uk)
  • The association between HLA-DRB1 gene and severity of rheumatoid arthritis (RA) has been documented in various reports. (bvsalud.org)
  • Compared with slower progressors, rapid progressors had a higher frequency of positivity for multiple (≥2) autoantibodies and had higher titres of ICA, IAA and IA-2A at seroconversion, and there was a higher prevalence of the secretor genotype in the FUT2 gene among those carrying the high-risk HLA genotype. (springer.com)
  • Compared with autoantibody-positive non-progressors, rapid progressors were younger, were more likely to carry the high-risk HLA genotype and a predisposing SNP in the PTPN22 gene, had higher frequency of ICA, IAA, GADA and IA-2A positivity and multipositivity, and had higher titres of all four autoantibodies at seroconversion. (springer.com)
  • Tonnelle, DeMars, Long: DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression. (antibodies-online.com)
  • The immune response HLA class II DRB1 gene provides the major genetic contribution to Juvenile Idiopathic Arthritis (JIA), with a hierarchy of predisposing through intermediate to protective effects. (pubmedcentralcanada.ca)
  • Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis. (naver.com)
  • Although each person has a limited repertoire of HLA-coded proteins based on Mendelian inheritance (two alleles of each major Class I and Class II gene), resistance to foreign antigens is maximized at the population level via allelic diversity 18,19 . (jneurology.com)
  • The frequency of the HLA class II alleles DRB1*0301 (Odds ratio [OR] = 2.01, 95% confidence interval [CI] = 1.31-3.10, Pc = 0.02) and DRB1*1501 (OR = 2.06, 95% CI = 1.36-3.13, Pc = 0.01) were both increased in SLE patients, compared to healthy controls. (nih.gov)
  • Interestingly, the patients with DRB1*1501 or 0404 had more crescent formation in glomeruli than those without the two alleles (p=0.021). (cdc.gov)
  • The RPEs test also showed a significant increased frequency of DRB1*0404 in anti-GBM disease (p=0.037). (cdc.gov)
  • Murine models of GD and HLA-transgenic mice have played a pivotal role in elucidating the immunological mechanisms. (frontiersin.org)
  • HLA-DR3 transgenic mice had significantly elevated eosinophil counts, Interleukin-4 and Interleukin-13 levels in the BAL fluid but not interferron gamma-γ. (elsevier.com)
  • DRB1*0405 typing has been performed by the sequence based typing method (SBT), that is a difficult and expensive method. (bvsalud.org)
  • We performed the HLA-DRB1*0405 typing using PCR-SSP technique with sequence specific primers of 3 pair in 298 Koreans. (bvsalud.org)
  • Of 298 samples typed with the high resolution SBT method, 60 samples were HLA-DRB1*04 positive and showed 9 subgroups of HLA-DRB1*04 and 26 samples were HLA- DRB1*0405 positive. (bvsalud.org)
  • Using PCR-SSP method to type HLA-DRB1*0405 is a very useful tools for studying the association between rheumatoid arthritis and HLA-DRB1*0405 from a practical and economic view. (bvsalud.org)
  • abstract = "We and others have reported that HLA-DRB1*03 is associated with childhood asthma. (elsevier.com)
  • This is exemplified by the association of DRB1*04:01 with either DRB4*01:01:101 or DRB4*01:03:101 (as in the cell lines BOLETH and SUD). (dorak.info)
  • Molecular identification of tumor rejection antigen has helped define several classes of antigen. (oncotarget.com)
  • Sorensen AL, Nagai S, Houen G, Andersen P, Andersen AB (1995) Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis . (springer.com)
  • Genotyping of HLA-DRB1 alleles was performed by polymerase chain reaction and hybridization with sequence-specific oligonucleotide probes on microbeads arrays. (biomedcentral.com)
  • More recently, detection of nucleotide sequence polymorphisms in the HLA class II region has become feasible with the advent of polymerase chain reaction (PCR) technique. (springer.com)
  • The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. (biomedsearch.com)
  • To identify candidates for the postulated sarcoidosis-specific antigen, lung cells from 16 HLA-DRB1*0301pos patients were obtained by bronchoalveolar lavage. (nih.gov)
  • HLA class II alleles in systemic sclerosis patients with anti-RNA polymerase I/III antibody: associations with subunit reactivities. (cdc.gov)
  • But the distribution of HLA-DRB1 alleles in Chinese patients with anti-GBM disease and their association with clinical characteristics of anti-GBM disease are to be determined. (cdc.gov)
  • The present study analyzed the HLA-DRB1 alleles by sequence based typing in 44 Chinese patients with anti-GBM disease and 200 healthy controls. (cdc.gov)
  • The research team led by Dr. John Hansen, head of the Program in Human Immunogentics at the Hutchinson Center, compared overall survival of 300 patients who received unrelated marrow transplants for chronic myeloid leukemia (CML) between 1985 and 1998. (fredhutch.org)
  • This may be useful in predicting early surgery in patients who do not carry two disease associated HLA-DR beta1 alleles. (uws.ac.uk)
  • Relationship between human leukocyte antigen DRB1 and psoriasis in Iraqi patients. (beds.ac.uk)
  • The increased use of DNA-based typing techniques has improved the accuracy and reliability of HLA types assigned to patients requiring an allogeneic bone marrow transplant and their potential donors, facilitating better donor selection. (meta.org)
  • Avoiding HLA-DR mismatching appears to be beneficial in pediatric kidney transplant patients, however the likelihood of finding a matching donor must be considered against the wait time for a possible donation, according to a report in the July issue of Archives of Surgery, one of the JAMA/Archives journals. (redorbit.com)
  • cell surface antigens that regulate host cell responses to transplanted cells] antigen mismatching has been shown to benefit long-term graft survival, it has raised concerns about disadvantaging minority groups, particularly black patients, and pediatric patients, who have severe growth retardation and other problems when dialysis is prolonged before transplantation," the authors write as background information in the article. (redorbit.com)
  • To examine the relationship between HLA-DR mismatching and rejection, graft survival and sensitization in pediatric kidney transplant patients, Lan T. Vu, M.D., and colleagues from the University of California at San Francisco, conducted a retrospective cohort study of 178 pediatric patients who underwent primary kidney transplantation with daclizumab induction therapy (to prevent organ rejection) at the University of California, San Francisco between 1997 and 2006. (redorbit.com)
  • Patients with 1- or 2-HLA-DRB1 mismatches had 1.7 times greater odds of rejection than patients with no HLA-DRB1 mismatches. (redorbit.com)
  • HLA-DRhigh/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus. (naver.com)
  • In a case-control association study, HLA-Cw*06 phenotype frequencies were compared between patients with PsA (n = 480), psoriasis alone (n = 611) and healthy controls (n = 166). (nih.gov)
  • The HLA-Cw*06 phenotype was associated with type I psoriasis (OR 6.9, 95% CI 4.4, 11.1, p = 2.2 x 10(-21)) and with patients with PsA having type I psoriasis (OR 5.0, 95% CI 3.2, 7.9, p = 4.39 x 10(-13)), but not with patients with PsA having type II psoriasis (age of onset >40 years). (nih.gov)
  • HLA-Cw*06 and HLA-DRB1*07 are associated with patients with PsA having type I psoriasis, suggesting that the primary association is with age of onset of psoriasis. (nih.gov)
  • However, the association with HLA-Cw*06 was confined to the subgroup of patients with PsA with type I psoriasis (OR 5.0, 95% CI 3.2, 7.9, p = 4.39×10−13) and was not observed in patients with PsA with type II psoriasis (OR 1.1, 95% CI 0.6, 2.1, p = 0.76). (nih.gov)