A synthetic tetracycline derivative with similar antimicrobial activity.
Substances that reduce the growth or reproduction of BACTERIA.
Closely congeneric derivatives of the polycyclic naphthacenecarboxamide. (Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1117)
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Compounds that inhibit the enzyme activity or activation of MATRIX METALLOPROTEINASES.
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.
Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.
A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.
Pharmacological agents destructive to nematodes in the superfamily Filarioidea.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A member of the MATRIX METALLOPROTEINASES that cleaves triple-helical COLLAGEN types I, II, and III.
Therapy with two or more separate preparations given for a combined effect.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

Inducible long-term gene expression in brain with adeno-associated virus gene transfer. (1/1810)

Recombinant adeno-associated virus (rAAV) vectors hold promise for treating a number of neurological disorders due to the ability to deliver long-term gene expression without toxicity or immune response. Critical to these endeavors will be controlled expression of the therapeutic gene in target cells. We have constructed and tested a dual cassette rAAV vector carrying a reporter gene under the control of the tetracycline-responsive system and the tetracycline transactivator. Transduction in vitro resulted in stable expression from the vector that can be suppressed 20-fold by tetracycline treatment. In vivo experiments, carried out to 6 weeks, demonstrated that vector-transduced expression is sustained until doxycycline administration upon which reporter gene expression is reduced. Moreover, the suppression of vector-driven expression can be reversed by removal of the drug. These studies demonstrate long-term regulated gene expression from rAAV vectors. This system will provide a valuable approach for controlling vector gene expression both in vitro and in vivo.  (+info)

Bioterrorism alleging use of anthrax and interim guidelines for management--United States, 1998. (2/1810)

From October 30 through December 23, 1998, CDC received reports of a series of bioterroristic threats of anthrax exposure. Letters alleged to contain anthrax were sent to health clinics on October 30, 1998, in Indiana, Kentucky, and Tennessee. During December 17-23 in California, a letter alleged to contain anthrax was sent to a private business, and three telephone threats of anthrax contamination of ventilation systems were made to private and public buildings. All threats were hoaxes and are under investigation by the Federal Bureau of Investigation (FBI) and local law enforcement officials. The public health implications of these threats were investigated to assist in developing national public health guidelines for responding to bioterrorism. This report summarizes the findings of these investigations and provides interim guidance for public health authorities on bioterrorism related to anthrax.  (+info)

Malaria prophylaxis using azithromycin: a double-blind, placebo-controlled trial in Irian Jaya, Indonesia. (3/1810)

New drugs are needed for preventing drug-resistant Plasmodium falciparum malaria. The prophylactic efficacy of azithromycin against P. falciparum in malaria-immune Kenyans was 83%. We conducted a double-blind, placebo-controlled trial to determine the prophylactic efficacy of azithromycin against multidrug-resistant P. falciparum malaria and chloroquine-resistant Plasmodium vivax malaria in Indonesian adults with limited immunity. After radical cure therapy, 300 randomized subjects received azithromycin (148 subjects, 750-mg loading dose followed by 250 mg/d), placebo (77), or doxycycline (75, 100 mg/d). The end point was slide-proven parasitemia. There were 58 P. falciparum and 29 P. vivax prophylaxis failures over 20 weeks. Using incidence rates, the protective efficacy of azithromycin relative to placebo was 71.6% (95% confidence interval [CI], 50.3-83.8) against P. falciparum malaria and 98.9% (95% CI, 93.1-99.9) against P. vivax malaria. Corresponding figures for doxycycline were 96.3% (95% CI, 85.4-99.6) and 98% (95% CI, 88.0-99.9), respectively. Daily azithromycin offered excellent protection against P. vivax malaria but modest protection against P. falciparum malaria.  (+info)

The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells. (4/1810)

Ionizing radiation activates the epidermal growth factor receptor (EGFR) and downstream signaling involving the cytoprotective mitogen-activated protein kinase (MAPK) pathway. In our effort to investigate the role of EGFR in cellular responses to radiation, we generated mammary carcinoma cell clones, MCF-TR5-EGFR-CD533 and MDA-TR15-EGFR-CD533, that inducibly express EGFR-CD533, a truncated EGFR mutant lacking mitogenic and transformation activity. EGFR-CD533 expression inhibits radiation- and EGF-induced EGFR autophosphorylation and MAPK activation and, therefore, functions as a dominant-negative mutant without blocking the expression of EGFR or erbB-2, another member of the erbB receptor Tyr kinase family. Expression of EGFR-CD533 only minimally inhibited cell growth and did not alter radiosensitivity to single radiation exposures. However, repeated 2 Gy radiation exposures of cells, under conditions of EGFR-CD533 expression, essentially abolished their ability for subsequent cell growth. These results identify the inhibition of EGFR function through genetic manipulation as a potential therapeutic maneuver. The concept of such an intervention would be the radiosensitization of cells by counteracting a radiation-induced cytoprotective proliferation response.  (+info)

Incorporation rates, stabilities, cytotoxicities and release of liposomal tetracycline and doxycycline in human serum. (5/1810)

Tetracycline and doxycycline were encapsulated in cationic, anionic and neutral liposomes. The amounts of antibiotic encapsulated, the stability of each preparation at 4 degrees C for 4 weeks, and the kinetics of the release of entrapped drug into human sera were assessed by high-performance liquid chromatography. The toxicities of the liposome preparations on human erythrocytes and HeLa 229 cells were evaluated in vitro. The results showed that doxycycline was entrapped more efficiently than tetracycline, and that doxycycline-entrapped liposomes were more stable at 4 degrees C and in human sera, and less cytotoxic than tetracycline-entrapped liposomes.  (+info)

Cellular responses to excess phospholipid. (6/1810)

Phosphatidylcholine (PtdCho) is the major membrane phospholipid in mammalian cells, and its synthesis is controlled by the activity of CDP:phosphocholine cytidylyltransferase (CCT). Enforced CCT expression accelerated the rate of PtdCho synthesis. However, the amount of cellular PtdCho did not increase as a result of the turnover of both the choline and glycerol components of PtdCho. Metabolic labeling experiments demonstrated that cells compensated for elevated CCT activity by the degradation of PtdCho to glycerophosphocholine (GPC). Phospholipase D-mediated PtdCho hydrolysis and phosphocholine formation were unaffected. Most of the GPC produced in response to excess phospholipid production was secreted into the medium. Cells also degraded the excess membrane PtdCho to GPC when phospholipid formation was increased by exposure to exogenous lysophosphatidylcholine or lysophosphatidylethanolamine. The replacement of the acyl moiety at the 1-position of PtdCho with a non-hydrolyzable alkyl moiety prevented degradation to GPC. Accumulation of alkylacyl-PtdCho was associated with the inhibition of cell proliferation, demonstrating that alternative pathways of degradation will not substitute. GPC formation was blocked by bromoenol lactone, implicating the calcium-independent phospholipase A2 as a key participant in the response to excess phospholipid. Owing to the fact that PtdCho is biosynthetically converted to PtdEtn, excess PtdCho resulted in overproduction and exit of GPE as well as GPC. Thus, general membrane phospholipid homeostasis is achieved by a balance between the opposing activities of CCT and phospholipase A2.  (+info)

Tetracycline up-regulates COX-2 expression and prostaglandin E2 production independent of its effect on nitric oxide. (7/1810)

Tetracyclines (doxycycline and minocycline) augmented (one- to twofold) the PGE2 production in human osteoarthritis-affected cartilage (in the presence or absence of cytokines and endotoxin) in ex vivo conditions. Similarly, bovine chondrocytes stimulated with LPS showed (one- to fivefold) an increase in PGE2 accumulation in the presence of doxycycline. This effect was observed at drug concentrations that did not affect nitric oxide (NO) production. In murine macrophages (RAW 264.7) stimulated with LPS, tetracyclines inhibited NO release and increased PGE2 production. Tetracycline(s) and L-N-monomethylarginine (L-NMMA) (NO synthase inhibitor) showed an additive effect on inhibition of NO and PGE2 accumulation, thereby uncoupling the effects of tetracyclines on NO and PGE2 production. The enhancement of PGE2 production in RAW 264.7 cells by tetracyclines was accompanied by the accumulation of both cyclooxygenase (COX)-2 mRNA and cytosolic COX-2 protein. In contrast to tetracyclines, L-NMMA at low concentrations (< or = 100 microM) inhibited the spontaneous release of No in osteoarthritis-affected explants and LPS-stimulated macrophages but had no significant effect on the PGE2 production. At higher concentrations, L-NMMA (500 microM) inhibited NO release but augmented PGE2 production. This study indicates a novel mechanism of action of tetracyclines to augment the expression of COX-2 and PGE2 production, an effect that is independent of endogenous concentration of NO.  (+info)

Use of doxycycline-controlled gene expression to reversibly alter milk-protein composition in transgenic mice. (8/1810)

A reverse tetracycline transactivator-encoding cDNA under the control of the mammary specific beta-lactoglobulin promoter was linked to a bovine alpha-lactalbumin transcription unit driven by a reverse tetracycline-controlled transactivator/doxycycline-inducible human cytomegalovirus promoter. The construct was microinjected into eggs from alpha-lactalbumin-deficient mice. These mice produce a highly viscous lactose-free milk and have a shortened lactation period. Mice from three out of the nine transgenic lines investigated expressed reverse tetracycline-controlled transactivator mRNA in their lactating mammary glands at levels detectable by Northern analysis. Following doxycycline addition to the drinking water, lactation was fully restored in animals from the three lines. Doxycycline removal resulted in a reversal of phenotype. The observed mammary-specific and high expression of the doxycycline inducible reporter gene (up to 5.2 mg of recombinant alpha-lactalbumin.mL-1 of milk, i.e. up to 13-fold induction) opens up exciting prospects to use the tetracycline system to study the development and functioning of the mammary gland, and to control the production level of active pharmaceutical proteins in the milk of transgenic animals.  (+info)

Doxycycline is a broad-spectrum antibiotic, which is a type of medication used to treat infections caused by bacteria and other microorganisms. It belongs to the tetracycline class of antibiotics. Doxycycline works by inhibiting the production of proteins that bacteria need to survive and multiply.

Doxycycline is used to treat a wide range of bacterial infections, including respiratory infections, skin infections, urinary tract infections, sexually transmitted diseases, and severe acne. It is also used to prevent malaria in travelers who are visiting areas where malaria is common.

Like all antibiotics, doxycycline should be taken exactly as directed by a healthcare professional. Misuse of antibiotics can lead to the development of drug-resistant bacteria, which can make infections harder to treat in the future.

It's important to note that doxycycline can cause photosensitivity, so it is recommended to avoid prolonged sun exposure and use sun protection while taking this medication. Additionally, doxycycline should not be taken during pregnancy or by children under the age of 8 due to potential dental and bone development issues.

Anti-bacterial agents, also known as antibiotics, are a type of medication used to treat infections caused by bacteria. These agents work by either killing the bacteria or inhibiting their growth and reproduction. There are several different classes of anti-bacterial agents, including penicillins, cephalosporins, fluoroquinolones, macrolides, and tetracyclines, among others. Each class of antibiotic has a specific mechanism of action and is used to treat certain types of bacterial infections. It's important to note that anti-bacterial agents are not effective against viral infections, such as the common cold or flu. Misuse and overuse of antibiotics can lead to antibiotic resistance, which is a significant global health concern.

Tetracyclines are a class of antibiotics that are widely used in medicine for their bacteriostatic properties, meaning they inhibit the growth of bacteria without necessarily killing them. They have a broad spectrum of activity and are effective against both Gram-positive and Gram-negative bacteria, as well as some other microorganisms such as rickettsiae, chlamydiae, and mycoplasmas.

Tetracyclines work by binding to the 30S subunit of the bacterial ribosome, thereby inhibiting protein synthesis and preventing the bacteria from multiplying. They are commonly used to treat a variety of infections, including respiratory tract infections, skin and soft tissue infections, urinary tract infections, sexually transmitted diseases, and anthrax exposure.

Some examples of tetracyclines include tetracycline, doxycycline, minocycline, and oxytetracycline. It is important to note that the use of tetracyclines during tooth development (pregnancy and up to the age of 8 years) can cause permanent discoloration of teeth, and they should be avoided in this population unless there are no other treatment options available. Additionally, tetracyclines can also cause photosensitivity, so patients should be advised to avoid excessive sun exposure while taking these medications.

Tetracycline is a broad-spectrum antibiotic, which is used to treat various bacterial infections. It works by preventing the growth and multiplication of bacteria. It is a part of the tetracycline class of antibiotics, which also includes doxycycline, minocycline, and others.

Tetracycline is effective against a wide range of gram-positive and gram-negative bacteria, as well as some atypical organisms such as rickettsia, chlamydia, mycoplasma, and spirochetes. It is commonly used to treat respiratory infections, skin infections, urinary tract infections, sexually transmitted diseases, and other bacterial infections.

Tetracycline is available in various forms, including tablets, capsules, and liquid solutions. It should be taken orally with a full glass of water, and it is recommended to take it on an empty stomach, at least one hour before or two hours after meals. The drug can cause tooth discoloration in children under the age of 8, so it is generally not recommended for use in this population.

Like all antibiotics, tetracycline should be used only to treat bacterial infections and not viral infections, such as the common cold or flu. Overuse or misuse of antibiotics can lead to antibiotic resistance, which makes it harder to treat infections in the future.

Matrix metalloproteinase inhibitors (MMPIs) are a class of pharmaceutical compounds that work by inhibiting the activity of matrix metalloproteinases (MMPs), which are a family of enzymes involved in the breakdown and remodeling of extracellular matrix (ECM) proteins. MMPs play important roles in various physiological processes, including tissue repair, wound healing, and angiogenesis, but they can also contribute to the pathogenesis of several diseases, such as cancer, arthritis, and cardiovascular disease.

MMPIs are designed to block the activity of MMPs by binding to their active site or zinc-binding domain, thereby preventing them from degrading ECM proteins. These inhibitors can be broad-spectrum, targeting multiple MMPs, or selective, targeting specific MMP isoforms.

MMPIs have been studied as potential therapeutic agents for various diseases, including cancer, where they have shown promise in reducing tumor growth, invasion, and metastasis by inhibiting the activity of MMPs that promote these processes. However, clinical trials with MMPIs have yielded mixed results, and some studies have suggested that broad-spectrum MMPIs may have off-target effects that can lead to adverse side effects. Therefore, there is ongoing research into developing more selective MMPIs that target specific MMP isoforms involved in disease pathogenesis while minimizing off-target effects.

Azithromycin is a widely used antibiotic drug that belongs to the class of macrolides. It works by inhibiting bacterial protein synthesis, which leads to the death of susceptible bacteria. This medication is active against a broad range of gram-positive and gram-negative bacteria, atypical bacteria, and some parasites.

Azithromycin is commonly prescribed to treat various bacterial infections, such as:

1. Respiratory tract infections, including pneumonia, bronchitis, and sinusitis
2. Skin and soft tissue infections
3. Sexually transmitted diseases, like chlamydia
4. Otitis media (middle ear infection)
5. Traveler's diarrhea

The drug is available in various forms, including tablets, capsules, suspension, and intravenous solutions. The typical dosage for adults ranges from 250 mg to 500 mg per day, depending on the type and severity of the infection being treated.

Like other antibiotics, azithromycin should be used judiciously to prevent antibiotic resistance. It is essential to complete the full course of treatment as prescribed by a healthcare professional, even if symptoms improve before finishing the medication.

Minocycline is an antibiotic medication that belongs to the tetracycline class. Medically, it is defined as a semisynthetic derivative of tetracycline and has a broader spectrum of activity compared to other tetracyclines. It is bacteriostatic, meaning it inhibits bacterial growth rather than killing them outright.

Minocycline is commonly used to treat various infections caused by susceptible bacteria, including acne, respiratory infections, urinary tract infections, skin and soft tissue infections, and sexually transmitted diseases. Additionally, it has been found to have anti-inflammatory properties and is being investigated for its potential use in treating neurological disorders such as multiple sclerosis and Alzheimer's disease.

As with all antibiotics, minocycline should be taken under the guidance of a healthcare professional, and its usage should be based on the results of bacterial culture and sensitivity testing to ensure its effectiveness against the specific bacteria causing the infection.

Brucellosis is a bacterial infection caused by the Brucella species, which are gram-negative coccobacilli. It is a zoonotic disease, meaning it can be transmitted from animals to humans. The most common way for humans to contract brucellosis is through consumption of contaminated animal products, such as unpasteurized milk or undercooked meat, from infected animals like goats, sheep, and cattle.

Humans can also acquire the infection through direct contact with infected animals, their tissues, or bodily fluids, especially in occupational settings like farming, veterinary medicine, or slaughterhouses. In rare cases, inhalation of contaminated aerosols or laboratory exposure can lead to brucellosis.

The onset of symptoms is usually insidious and may include fever, chills, night sweats, headache, muscle and joint pain, fatigue, and loss of appetite. The infection can disseminate to various organs, causing complications such as endocarditis, hepatomegaly, splenomegaly, orchitis, and epididymoorchitis.

Diagnosis is confirmed through blood cultures, serological tests, or molecular methods like PCR. Treatment typically involves a long course of antibiotics, such as doxycycline combined with rifampin or streptomycin. Prevention measures include pasteurization of dairy products and cooking meat thoroughly before consumption. Vaccination is available for high-risk populations but not for general use due to the risk of adverse reactions and potential interference with serodiagnosis.

Oxytetracycline is a broad-spectrum antibiotic, which is part of the tetracycline class. It works by inhibiting bacterial protein synthesis, thereby preventing bacterial growth and reproduction. Medical definition: "A linear tetra cyclic amide antibiotic derived from Streptomyces rimosus, with a wide range of antibacterial activity against both Gram-positive and Gram-negative organisms. It is used especially in the treatment of rickettsial infections, respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases." (Source: Dorland's Illustrated Medical Dictionary)

Filaricides are a type of medication used to treat infections caused by filarial worms, which are parasitic roundworms that can infect humans and animals. These medications work by killing or inhibiting the development of the larval stages of the worms, thereby helping to eliminate the infection and prevent further transmission.

Filaricides are often used to treat diseases such as onchocerciasis (river blindness), lymphatic filariasis (elephantiasis), and loiasis (African eye worm). Examples of filaricides include ivermectin, diethylcarbamazine, and albendazole. It is important to note that these medications should only be used under the guidance of a healthcare professional, as they can have serious side effects if not used properly.

Microbial sensitivity tests, also known as antibiotic susceptibility tests (ASTs) or bacterial susceptibility tests, are laboratory procedures used to determine the effectiveness of various antimicrobial agents against specific microorganisms isolated from a patient's infection. These tests help healthcare providers identify which antibiotics will be most effective in treating an infection and which ones should be avoided due to resistance. The results of these tests can guide appropriate antibiotic therapy, minimize the potential for antibiotic resistance, improve clinical outcomes, and reduce unnecessary side effects or toxicity from ineffective antimicrobials.

There are several methods for performing microbial sensitivity tests, including:

1. Disk diffusion method (Kirby-Bauer test): A standardized paper disk containing a predetermined amount of an antibiotic is placed on an agar plate that has been inoculated with the isolated microorganism. After incubation, the zone of inhibition around the disk is measured to determine the susceptibility or resistance of the organism to that particular antibiotic.
2. Broth dilution method: A series of tubes or wells containing decreasing concentrations of an antimicrobial agent are inoculated with a standardized microbial suspension. After incubation, the minimum inhibitory concentration (MIC) is determined by observing the lowest concentration of the antibiotic that prevents visible growth of the organism.
3. Automated systems: These use sophisticated technology to perform both disk diffusion and broth dilution methods automatically, providing rapid and accurate results for a wide range of microorganisms and antimicrobial agents.

The interpretation of microbial sensitivity test results should be done cautiously, considering factors such as the site of infection, pharmacokinetics and pharmacodynamics of the antibiotic, potential toxicity, and local resistance patterns. Regular monitoring of susceptibility patterns and ongoing antimicrobial stewardship programs are essential to ensure optimal use of these tests and to minimize the development of antibiotic resistance.

Matrix Metalloproteinase 8 (MMP-8), also known as Collagenase-2 or Neutrophil Collagenase, is an enzyme that belongs to the Matrix Metalloproteinases family. MMP-8 is primarily produced by neutrophils and has the ability to degrade various components of the extracellular matrix (ECM), including collagens, gelatin, and elastin. It plays a crucial role in tissue remodeling, wound healing, and inflammatory responses. MMP-8 is also involved in the pathogenesis of several diseases, such as periodontitis, rheumatoid arthritis, and cancer, where it contributes to the breakdown of the ECM and promotes tissue destruction and invasion.

Combination drug therapy is a treatment approach that involves the use of multiple medications with different mechanisms of action to achieve better therapeutic outcomes. This approach is often used in the management of complex medical conditions such as cancer, HIV/AIDS, and cardiovascular diseases. The goal of combination drug therapy is to improve efficacy, reduce the risk of drug resistance, decrease the likelihood of adverse effects, and enhance the overall quality of life for patients.

In combining drugs, healthcare providers aim to target various pathways involved in the disease process, which may help to:

1. Increase the effectiveness of treatment by attacking the disease from multiple angles.
2. Decrease the dosage of individual medications, reducing the risk and severity of side effects.
3. Slow down or prevent the development of drug resistance, a common problem in chronic diseases like HIV/AIDS and cancer.
4. Improve patient compliance by simplifying dosing schedules and reducing pill burden.

Examples of combination drug therapy include:

1. Antiretroviral therapy (ART) for HIV treatment, which typically involves three or more drugs from different classes to suppress viral replication and prevent the development of drug resistance.
2. Chemotherapy regimens for cancer treatment, where multiple cytotoxic agents are used to target various stages of the cell cycle and reduce the likelihood of tumor cells developing resistance.
3. Cardiovascular disease management, which may involve combining medications such as angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, diuretics, and statins to control blood pressure, heart rate, fluid balance, and cholesterol levels.
4. Treatment of tuberculosis, which often involves a combination of several antibiotics to target different aspects of the bacterial life cycle and prevent the development of drug-resistant strains.

When prescribing combination drug therapy, healthcare providers must carefully consider factors such as potential drug interactions, dosing schedules, adverse effects, and contraindications to ensure safe and effective treatment. Regular monitoring of patients is essential to assess treatment response, manage side effects, and adjust the treatment plan as needed.

Anti-infective agents are a class of medications that are used to treat infections caused by various microorganisms such as bacteria, viruses, fungi, and parasites. These agents work by either killing the microorganism or inhibiting its growth, thereby helping to control the infection and alleviate symptoms.

There are several types of anti-infective agents, including:

1. Antibiotics: These are medications that are used to treat bacterial infections. They work by either killing bacteria (bactericidal) or inhibiting their growth (bacteriostatic).
2. Antivirals: These are medications that are used to treat viral infections. They work by interfering with the replication of the virus, preventing it from spreading and causing further damage.
3. Antifungals: These are medications that are used to treat fungal infections. They work by disrupting the cell membrane of the fungus, killing it or inhibiting its growth.
4. Antiparasitics: These are medications that are used to treat parasitic infections. They work by either killing the parasite or inhibiting its growth and reproduction.

It is important to note that anti-infective agents are not effective against all types of infections, and it is essential to use them appropriately to avoid the development of drug-resistant strains of microorganisms.

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"Doxycycline Prophylaxis for Bacterial Sexually Transmitted Infections". Clinical Infectious Diseases. 70 (6): 1247-1253. doi: ...
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  • This fact sheet provides instructions for the use of doxycycline for post-exposure prophylaxis (PEP) during an emergency involving anthrax (referred to as Emergency Use Instructions (EUI) fact sheet). (cdc.gov)
  • Doxycycline post-exposure prophylaxis to prevent STIs is a novel promising intervention, which in a new study caused an ∼ 65% reduction in incident STIs. (nature.com)
  • Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial. (nature.com)
  • Mortimer, T. D. & Grad, Y. H. A genomic perspective on the near-term impact of doxycycline post-exposure prophylaxis on Neisseria gonorrhoeae antimicrobial resistance. (nature.com)
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  • Children younger than 8 years old should not take doxycycline. (health32.com)
  • Field trials in 2005 showed an eight-week course of doxycycline almost eliminates the release of microfilariae. (wikipedia.org)
  • Conclusions: A 3-day course of doxycycline appears to be as effective as a 7-day course of doxycycline for the treatment of uncomplicated chlamydia cervicitis. (onteenstoday.com)
  • Doxycycline hyclate is an antibacterial drug synthetically derived from oxytetracycline. (nih.gov)
  • Doxycycline has antibacterial and anti-inflammatory effects. (doctorfox.co.uk)
  • you should know that doxycycline injection may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections). (medlineplus.gov)
  • The safety and effectiveness of doxycycline have not been established in children 8 years of age or older. (mayoclinic.org)
  • Make sure you let us know if you are taking other medications when our clinicians prescribe you your acne treatment, as Doxycycline can interfere with the effectiveness of other treatments. (lloydspharmacy.com)
  • Doxycycline may also affect the effectiveness of birth control pills. (anytimedoctor.co.uk)
  • When it comes to treating lung infections, trust in the effectiveness of Doxycycline. (tangorm.com)
  • Does Sericin, as a Novel Pleurodesis Agent, Have Higher Effectiveness Compared to Talcum Powder, Doxycycline, and Silver Nitrate Pleurodesis? (archbronconeumol.org)
  • Doxycycline is also used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to anthrax in the air and to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). (medlineplus.gov)
  • If you still have symptoms of infection after you finish doxycycline injection, tell your doctor. (medlineplus.gov)
  • Inform recipients that mild gastrointestinal side effects such as nausea, vomiting, and/or diarrhea, a mild sunburn or a vaginal yeast infection may be experienced but to continue taking doxycycline. (cdc.gov)
  • Uptake of DoxyPEP resulted in initial drops in the prevalence and incidence of gonorrhea infection, but also accelerated the spread of doxycycline resistance, with increasing DoxyPEP use driving steeper initial declines followed by faster spread of resistance. (nih.gov)
  • The magnitude by which DoxyPEP initially reduced the prevalence of infection was constrained by the extent of pre-existing doxycycline resistant strains in the population. (nih.gov)
  • Model findings suggest DoxyPEP can be an effective but short-term solution for reducing the burden of gonorrhea infection, as its selection for doxycycline-resistant strains results in loss of its prophylaxis benefit. (nih.gov)
  • In many cases, Doxycycline can provide rapid relief from symptoms and help clear the infection within a relatively short period of time. (tangorm.com)
  • If you are experiencing symptoms of a lung infection, it is important to consult with your healthcare provider to determine if Doxycycline is the appropriate treatment option for you. (tangorm.com)
  • When taking doxycycline for a lung infection, it is important to follow the prescribed dosage and complete the full course of treatment. (tangorm.com)
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  • In a transssectional survey, nasal carriage of this strain was found in 2.9% of 273 soldiers about to be sent to Côte d'Ivoire and was associated with prior malaria prophylaxis with doxycycline. (cdc.gov)
  • Company A comprised 70 French soldiers who had taken doxycycline, 100 mg per day, for malaria prophylaxis while in Côte d'Ivoire (August-November 2003). (cdc.gov)
  • Do not give doxycycline to anyone who is allergic to doxycycline or another antibiotic in the tetracycline class. (cdc.gov)
  • Up to 57% of P. acnes strains developed resistance to doxycycline. (wikipedia.org)
  • Before starting treatment with doxycycline, there are several precautions that should be taken into consideration. (doxycycline4day.top)
  • This will help them determine if doxycycline is safe for you to use and if any precautions need to be taken. (doxycycline4day.top)
  • For those in clinical practice who are using oral doxycycline to treat MGD with dosing as in this trial, this trial provides strong evidence that switching to azithromycin provides similar efficacy with lower risk of gastrointestinal adverse effects," she added. (medpagetoday.com)
  • Doxycycline is an antibiotic with known gastrointestinal (GI) adverse effects . (bvsalud.org)
  • Twelve patients (6.3%) reported having GI adverse effects resulting in doxycycline discontinuation in five of them (2.6%), and three patients (1.6%) had esophagitis . (bvsalud.org)
  • Doxycycline Overdose If you take too much doxycycline, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. (onteenstoday.com)
  • If doxycycline is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. (onteenstoday.com)
  • What should I discuss with my healthcare provider before taking Alodox (Doxycycline)? (health32.com)
  • Additionally, it is important to take doxycycline exactly as prescribed by your healthcare provider. (doxycycline4day.top)
  • As Doxycycline is an antibiotic, it works to eradicate the bacteria that cause acne, therefore preventing further acne from forming. (lloydspharmacy.com)
  • 1 The Food and Drug Administration (FDA) has also issued an order permitting the emergency dispensing of oral formulations of doxycycline without a prescription during an anthrax emergency to individuals who may have been exposed to B. anthracis . (cdc.gov)
  • Follow the instructions provided with the oral suspension to mix the doxycycline powder with water before dispensing the drug to the recipient. (cdc.gov)
  • Children weighing less than 30 lbs (14 kg) should take doxycycline oral suspension dosed by weight every 12 hours. (cdc.gov)
  • Each capsule for oral administration contains doxycycline hyclate equivalent to 50 mg or 100 mg of doxycycline (anhydrous). (nih.gov)
  • Doxycycline is virtually completely absorbed after oral administration. (nih.gov)
  • The approximate incidences with a storage a toupee I contains high potencies Propecia, I had he is restless where to buy cheap doxycycline increases with high in fish with lowdose oral. (grey-panthers.it)
  • This retrospective descriptive study included adults who received oral doxycycline for at least one month between 2016 and 2018. (bvsalud.org)
  • Three treatments available include oral doxycycline, injectable doxycycline, and injectable oxytetracycline. (cdc.gov)
  • Doxycycline comes as a capsule, tablet, delayed-release tablet, and suspension (liquid) to take by mouth. (medlineplus.gov)
  • you should know that when doxycycline is used during pregnancy or in babies or children up to age 8, it can cause the teeth to become permanently stained and can cause problems with bone growth. (medlineplus.gov)
  • Is it safe to take Doxycycline or apply Azelaic Acid gel during pregnancy or breastfeeding? (lloydspharmacy.com)
  • Just the same, taking doxycycline later in the last half of the pregnancy could result in permanent discolouration of your child's teeth than in life. (anytimedoctor.co.uk)
  • Use a non-hormonal method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while you are taking doxycycline. (health32.com)
  • Increasing levels of DoxyPEP uptake and higher starting prevalence of doxycycline resistance resulted in faster loss of its efficacy and had little change on extending the clinical lifespan of ceftriaxone for treatment of N. gonorrhoeae infections. (nih.gov)
  • Furthermore, the use of generic doxycycline is supported by the FDA, which confirms its safety and efficacy. (doxycycline24x365.top)
  • Doxycycline has been reported as a potential sclerotherapy agent, with both safety and efficacy. (medscape.com)
  • Doxycycline is used to treat a variety of infections caused by certain types of bacteria. (medlineplus.gov)
  • As an anti-bacterial medicine doxycycline is used to treat a wide range of infections caused by bacteria. (doctorfox.co.uk)
  • Doxycycline is particularly effective in treating lung infections caused by bacteria such as pneumonia, bronchitis, and sinusitis. (tangorm.com)
  • In conclusion, Doxycycline is a reliable and effective antibiotic for the treatment of various lung infections. (tangorm.com)
  • Conclusion: Doxycycline has small beneficial effects in patients with acute cough and purulent sputum. (david-cook.org)
  • Doxycycline has bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria. (nih.gov)
  • Doxycycline is bacteriostatic which means it stops bacteria from reproducing, but doesn't necessarily kill them. (onteenstoday.com)
  • Can doxycycline help treat my symptoms? (dane101.com)
  • Doxycycline also has anti-inflammatory properties which can help reduce some symptoms associated with infections so it's double beneficial. (dane101.com)
  • Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use. (onteenstoday.com)
  • Most symptoms of a doxycycline overdose include an increased risk of side effects, which can include nausea, vomiting, and diarrhea. (onteenstoday.com)
  • Many patients notice an improvement in symptoms within a few days of starting Doxycycline treatment. (tangorm.com)
  • Doxycycline is also used along with other medications to treat acne and rosacea (a skin disease that causes redness, flushing, and pimples on the face). (medlineplus.gov)
  • Like Doxycycline, Azelaic Acid gel also kills acne causing bacteria, therefore the combination of the two medications will improve your chances of reducing acne. (lloydspharmacy.com)
  • The vet ordered doxycycline and prednisone for two weeks and a follow-up after the medications were finished. (askavetquestion.com)
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  • It is also worth noting that doxycycline can interact with other medications and substances. (doxycycline4day.top)
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  • Vor allem Doxycyclin, ein Antibiotikum aus der Gruppe der Tetracycline, sowie COL-3, ein chemisch modifiziertes Tetracyclinderivat, wurden an vielen Tumorentitäten in präklinischen und klinischen Studien erfolgreich eingesetzt. (uni-wuerzburg.de)
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  • Doxycycline (Oracea) is used only to treat pimples and bumps caused by rosacea. (medlineplus.gov)
  • Doxycycline is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. (health32.com)
  • Doxycycline will not treat facial redness caused by rosacea. (health32.com)
  • Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. (nih.gov)
  • If you are taking doxycycline for the prevention of malaria, start taking it 1 or 2 days before traveling to an area where there is malaria. (medlineplus.gov)
  • Doxycycline is for the prevention and treatment of local & systemic infections in racing pigeons, pets, poultry & exotic birds. (cutlersupply.com)
  • Increased health care provider and public health awareness of the prevalence and severity of fleaborne typhus and of the importance of early doxycycline therapy is essential for prevention and treatment efforts. (medscape.com)
  • Doxycycline kills the symbiotic Wolbachia bacteria in the reproductive tracts of parasitic filarial nematodes, making the nematodes sterile, and thus reducing transmission of diseases such as onchocerciasis and elephantiasis. (wikipedia.org)
  • The reason doxycycline kills bacteria and parasites, but not our own cells, is that ours have a different type of ribosome to these simpler organisms. (onteenstoday.com)
  • Both dairy products and iron-rich foods can interfere with doxycycline if taken at the same time. (david-cook.org)
  • Doxycycline can make birth control pills less effective. (health32.com)
  • Intramuscular (IM) injection into the pectoral muscle is often the easiest method of treatment, but not all injectable-doxycycline formulations are suitable for IM injection. (cdc.gov)
  • Moraxella catarrhalis, Brucella melitensis, Chlamydia pneumoniae, and Mycoplasma pneumoniae are generally susceptible to doxycycline, while some Haemophilus spp. (wikipedia.org)
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