The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
The giving of drugs, chemicals, or other substances by mouth.
The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.
Elements of limited time intervals, contributing to particular results or situations.
The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.
Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Injections made into a vein for therapeutic or experimental purposes.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
The total amount of a chemical, metal or radioactive substance present at any time after absorption in the body of man or animal.
The use of a device composed of thermoluminescent material for measuring exposure to IONIZING RADIATION. The thermoluminescent material emits light when heated. The amount of light emitted is proportional to the amount of ionizing radiation to which the material has been exposed.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.
Therapy with two or more separate preparations given for a combined effect.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A small aerosol canister used to release a calibrated amount of medication for inhalation.
The observation, either continuously or at intervals, of the levels of radiation in a given area, generally for the purpose of assuring that they have not exceeded prescribed amounts or, in case of radiation already present in the area, assuring that the levels have returned to those meeting acceptable safety standards.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Organs which might be damaged during exposure to a toxin or to some form of therapy. It most frequently refers to healthy organs located in the radiation field during radiation therapy.
A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Antibodies produced by a single clone of cells.
The action of a drug in promoting or enhancing the effectiveness of another drug.
Measurement of radioactivity in the entire human body.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Proteins prepared by recombinant DNA technology.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
In statistics, a technique for numerically approximating the solution of a mathematical problem by studying the distribution of some random variable, often generated by a computer. The name alludes to the randomness characteristic of the games of chance played at the gambling casinos in Monte Carlo. (From Random House Unabridged Dictionary, 2d ed, 1993)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Schedule giving optimum times usually for primary and/or secondary immunization.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Use of a device (film badge) for measuring exposure of individuals to radiation. It is usually made of metal, plastic, or paper and loaded with one or more pieces of x-ray film.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Unstable isotopes of cesium that decay or disintegrate emitting radiation. Cs atoms with atomic weights of 123, 125-132, and 134-145 are radioactive cesium isotopes.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Tumors or cancer of the LUNG.
A decrease in the number of NEUTROPHILS found in the blood.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
The highest dosage administered that does not produce toxic effects.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Devices that cause a liquid or solid to be converted into an aerosol (spray) or a vapor. It is used in drug administration by inhalation, humidification of ambient air, and in certain analytical instruments.
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
The observable response an animal makes to any situation.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
A family of hexahydropyridines.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The rate dynamics in chemical or physical systems.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
Substances that reduce the growth or reproduction of BACTERIA.
Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The forcible expulsion of the contents of the STOMACH through the MOUTH.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Substances that reduce or suppress INFLAMMATION.
Penetrating electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the GAMMA RAYS wavelength range. The distinction between gamma rays and X-rays is based on their radiation source.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
The material that descends to the earth or water well beyond the site of a surface or subsurface nuclear explosion. (McGraw-Hill Dictionary of Chemical and Technical Terms, 4th ed)
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
Introduction of substances into the body using a needle and syringe.
A subnormal level of BLOOD PLATELETS.
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
The use of pre-treatment imaging modalities to position the patient, delineate the target, and align the beam of radiation to achieve optimal accuracy and reduce radiation damage to surrounding non-target tissues.
Drugs used to prevent SEIZURES or reduce their severity.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
An encapsulated lymphatic organ through which venous blood filters.
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.
The physical activity of a human or an animal as a behavioral phenomenon.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically.
Computer systems or programs used in accurate computations for providing radiation dosage treatment to patients.
Rhenium. A metal, atomic number 75, atomic weight 186.2, symbol Re. (Dorland, 28th ed)
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Uptake of substances through the lining of the INTESTINES.
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Injections into the cerebral ventricles.
A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Antimetabolites that are useful in cancer chemotherapy.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Computed tomography modalities which use a cone or pyramid-shaped beam of radiation.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
The return of a sign, symptom, or disease after a remission.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
OXIDOREDUCTASES which mediate vitamin K metabolism by converting inactive vitamin K 2,3-epoxide to active vitamin K.
Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.
A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Uncontrolled release of radioactive material from its containment. This either threatens to, or does, cause exposure to a radioactive hazard. Such an incident may occur accidentally or deliberately.
The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
The use of an external beam of PROTONS as radiotherapy.
The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.
Tumors or cancer of the human BREAST.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.
Unstable isotopes of iridium that decay or disintegrate emitting radiation. Ir atoms with atomic weights 182-190, 192, and 194-198 are radioactive iridium isotopes.
Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.
Warfare involving the use of NUCLEAR WEAPONS.
... dose, and/or dose rate, for example, for verifying that radiation protection equipment and procedures are effective on an ... In response to increased concern by the public over radiation doses and the ongoing progress of best practices, The Alliance ... The radiation dose received from DEXA scans is very low, much lower than projection radiography examinations.[citation needed] ... Radiation dose[edit]. The dosage of radiation applied in radiography varies by procedure. For example, the effective dosage of ...
The dose of the coagulant to be used can be determined via the Jar Test.[1][6] The jar test involves exposing same volume ... Jar test: Mixing different doses of coagulant with samples of the water to be treated ... Coagulation is affected by the type of coagulant used, its dose and mass; pH and initial turbidity of the water that is being ... Then the turbidity of the samples are measured and the dose with the lowest turbidity can be said to be optimum. ...
Trade names and dose form[edit]. For oral inhalation and for nebulizer use:[8] ... "NebuPent, Pentam (pentamidine) dosing, indications, interactions, adverse effects, and more". reference.medscape.com. Archived ... 45.31 a dose.[8] Since it was found useful for PCP pneumonia the price has been increased greater than ten times.[5] ... It is unclear if doses should be changed in those with kidney or liver problems.[1] Pentamidine is not recommended in early ...
Normal doses are safe during pregnancy.[10] The United States Institute of Medicine recommends against taking large doses.[3] ... Pauling popularized the concept of high dose vitamin C as prevention and treatment of the common cold in 1970. A few years ... Large doses[edit]. Further information: Vitamin C megadosage. Vitamin C megadosage is a term describing the consumption or ... However, at doses above 1,000 mg/day, absorption falls to less than 50%."[5] It is transported through the intestine via both ...
This is a radiation treatment in which the total dose of radiation is divided into large doses. Typical doses vary ... Side effects are dose- dependent; for example higher doses of head and neck radiation can be associated with cardiovascular ... It only occurs within the radiation field/s. Hair loss may be permanent with a single dose of 10 Gy, but if the dose is ... The planner will try to design a plan that delivers a uniform prescription dose to the tumor and minimizes dose to surrounding ...
Dosing regimen[edit]. Drug. Standard [R]-CHOP-14 or [R]-CHOP-21. [R]-Maxi-CHOP. Mode. Days ... R-Maxi-CHOP is used in mantle cell lymphoma and is given in 21-day intervals, alternating with R-HDAC (rituximab + high-dose ... Doses in that regimen were increased from cycle to cycle. This regimen was called [R]-MegaCHOEP. But again, such escalation ... Dose-escalated CHOEP for the treatment of young patients with aggressive non-Hodgkin's lymphoma: II. Results of the randomized ...
Larger doses and pack sizes still require a prescription. Dosing[edit]. For ulcer treatment, a night-time dose is especially ... Ranitidine enters breast milk, with peak concentrations seen at 5.5 hours after the dose in breast milk. Caution should be ... In addition, about 30% of the orally administered dose is collected in the urine as non-absorbed drug in 24 hours. ... Previously manufactured by Boehringer Ingleheim) In Australia and the UK, packs containing seven or 14 doses of the 150-mg ...
The radiation doses received from CT scans is variable. Compared to the lowest dose x-ray techniques, CT scans can have 100 to ... Scan dose[edit]. Examination Typical effective dose (mSv). to the whole body Typical absorbed dose (mGy). to the organ in ... The equivalent dose is the effective dose of a case, in which the whole body would actually absorb the same radiation dose, and ... with the highest-dose CT techniques. In general, the radiation dose associated with a routine abdominal CT has a radiation dose ...
Dosing[edit]. Filling an insulin pump reservoir. (Left to right) 1: Reservoir in sterile packaging. 2: Filling the reservoir. 3 ... a basal dose that is pumped continuously at an adjustable basal rate to deliver insulin needed between meals and at night. ... a bolus dose that is pumped to cover food eaten or to correct a high blood glucose level. ... By pumping with a "square wave" shape, the bolus avoids a high initial dose of insulin that may enter the blood and cause low ...
Dosing considerations[edit]. Intravenous vs oral administration[edit]. Vancomycin must be given intravenously (IV) for systemic ... Vancomycin is available as a generic medication.[5] The wholesale cost of an intravenous dose is about US$1.70 to 6.00.[10] In ... However, a dose- or serum level-effect relationship has not been established. ... Karam, CM; McKinnon, PS; Neuhauser, MM; Rybak, MJ (1999). "Outcome assessment of minimizing vancomycin monitoring and dosing ...
It is available in 2.5 mg, 5 mg, 10 mg, and 20 mg doses in round orange tablets. The normal starting dose is 10 mg[11] (roughly ... with a maximum dose frequency of once per day. In some territories, such as the UK, only certain doses may be available. ...
Dose[edit]. Ceritinib is available as a 150 mg capsule with a one-time daily dosing requirement of 450 mg with food.[10] ... "ZYKADIA® (ceritinib) Dosing & Administration , HCP". www.hcp.novartis.com. Retrieved 2019-04-28.. ...
The radiation doses received from CT scans is variable. Compared to the lowest dose x-ray techniques, CT scans can have 100 to ... Scan dose[edit]. Examination Typical effective dose (mSv). to the whole body Typical absorbed dose (mGy). to the organ in ... The equivalent dose is the effective dose of a case, in which the whole body would actually absorb the same radiation dose, and ... Rob, S.; Bryant, T.; Wilson, I.; Somani, B.K. (2017). "Ultra-low-dose, low-dose, and standard-dose CT of the kidney, ureters, ...
it has been shown that the repeated oral administration of NET at doses of 0.5 to 3.0 mg to fertile women caused a dose related ... The medication available in both low-dose and high-dose formulations and is used and formulated both alone and in combination ... Dose. Brand names. Use NET only. Low (e.g., 0.35 mg). Camila, Errin, Heather, Jencycla, Jolivette, Locilan, Micro-Novum, ... High-dose (10 mg/day) norethisterone has been associated with hepatic veno-occlusive disease, and because of this adverse ...
Side-effects of high doses and long-term use[edit]. Some of the side effects reportedly seen in previously healthy mature ... Some recent small clinical studies have shown that low-dose GH treatment for elderly patients with GH deficiency changes the ... effects of low-dose growth hormone replacement". Clinical Endocrinology. 54 (6): 709-17. doi:10.1046/j.1365-2265.2001.01275.x. ...
Dosing interval. Time between drug dose administrations.. τ. {\displaystyle \tau }. s. {\displaystyle \mathrm {s} }. Design ... after a single dose or in steady state). A. U. C. 0. −. ∞. {\displaystyle AUC_{0-\infty }}. M. ⋅. s. {\displaystyle \mathrm {M ... Peak trough fluctuation within one dosing interval at steady state.. %. P. T. F. {\displaystyle \%PTF}. %. {\displaystyle \%}. ... Dose. Amount of drug administered.. D. {\displaystyle D}. m. o. l. {\displaystyle \mathrm {mol} }. Design parameter 500 mmol ...
Time: Reducing the time of an exposure reduces the effective dose proportionally. An example of reducing radiation doses by ... Recommended limits on dose uptake[edit]. USA Dept of Energy 2010 dose chart in sieverts for a variety of situations and ... Factors in external dose uptake[edit]. Main article: sievert. There are three factors that control the amount, or dose, of ... The risk from a low level internal source is represented by the dose quantity committed dose, which has the same risk as the ...
750 million doses could be produced each year, whereas it is likely that each individual would need two doses of the vaccine in ... Dose-sparing technologies. Current U.S.-licensed vaccines stimulate an immune response based on the quantity of HA ( ... The US government purchased from Sanofi Pasteur and Chiron Corporation several million doses of vaccine meant to be used in ... Dose-sparing technologies. Current U.S.-licensed vaccines stimulate an immune response based on the quantity of HA ( ...
The abuse potential or drug-liking effects appears to be dose related, with low doses of benzodiazepines having limited drug ... As many as 30-50% of alcoholics are also benzodiazepine misusers.[14] Drug abusers often abuse high doses which makes serious ... Illicit users of benzodiazepines have been found to take higher methadone doses, as well as showing more HIV/HCV risk-taking ... A high degree of tolerance often occurs in chronic benzodiazepine abusers due to the typically high doses they consume which ...
... or dizziness at high doses.[8] ... Metered-dose inhaler (MDI). Gas. *Oxygen mask and Nasal cannula ...
An epinephrine autoinjector (or adrenaline autoinjector) is a medical device for injecting a measured dose or doses of ... A second dose is needed in 16-35% of episodes with more than two doses rarely required; in around 80% of the cases where a ... The devices contain a fixed dose of epinephrine and a spring-loaded needle (or, in the case of AuviQ, a CO2-driven needle) that ... In 2013, emergency physician Seth C. Hawkins and coauthors published a technique for obtaining multiple additional doses of ...
with a glucose tolerance test, two hours after the oral dose a plasma glucose ≥ 11.1 mmol/l (200 mg/dl) ... Doses are then increased to effect (blood sugar levels being well controlled).[25] When nightly insulin is insufficient, twice ... systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013". BMJ. 354: i3857. doi:10.1136/ ... although the benefit of self-monitoring in those not using multi-dose insulin is questionable.[25] In those who do not want to ...
... wears off quickly after dosing. Unboosted indinavir requires a very precise dosing of 400 mg every eight hours to ... Indinavir cost about $12 for a daily dose, which is 24% less than Invirase and 33% less than Norvir.[14] Because the company ...
Drug sensitization occurs in drug addiction, and is defined as an increased effect of drug following repeated doses (the ... tolerance - the diminishing effect of a drug resulting from repeated administration at a given dose ... exposure to sufficiently high doses of a drug for long periods of time can transform someone who has relatively lower genetic ... the escalating effect of a drug resulting from repeated administration at a given dose ...
The effectiveness of spironolactone for acne appears to be dose-dependent.[102] High-dose cyproterone acetate alone reportedly ... even at low doses, with several studies showing complete acne clearance.[112][121][122] In one study, flutamide decreased acne ... Brandstetter AJ, Maibach HI (August 2013). "Topical dose justification: benzoyl peroxide concentrations". The Journal of ... low-dose doxycycline is not FDA-approved for the treatment of acne.[92] Antibiotics applied to the skin are typically used for ...
... while requiring high doses of immunosuppressive agents in the early stages of treatment, these doses are less than for ... High-dose corticosteroids such as prednisone are a standard treatment; however this immuno-suppressive treatment often leads to ... Filgrastim is typically dosed in the 10 microgram/kg level for 4-5 days during the harvesting of stem cells. The documented ... p. 96, "Radiation doses were intense, being estimated at 205, 320, 410, 415, 422, and 433 rem. Of the six persons present, one ...
Alcohol is a depressant, which in low doses causes euphoria, reduces anxiety, and increases sociability. In higher doses, it ... Caton, S.J.; Ball, M; Ahern, A; Hetherington, M.M. (2004). "Dose-dependent effects of alcohol on appetite and food intake". ...
Too high a dose of levothyroxine causes hyperthyroidism.[18] Overdose can result in heart palpitations, abdominal pain, nausea ... Poor compliance in taking the medicine is the most common cause of elevated TSH levels in people receiving appropriate doses of ... Adverse events are generally caused by incorrect dosing. Long-term suppression of TSH values below normal values will ... Side effects from excessive doses include weight loss, trouble tolerating heat, sweating, anxiety, trouble sleeping, tremor, ...
Where hyperalgesia has been produced by chronic high doses of opioids, reducing the dose may result in improved pain management ... Long-term opioid (e.g. heroin, morphine) users and those on high-dose opioid medications for the treatment of chronic pain, may ... opioid-induced hyperalgesia is often compensated for by escalating the dose of opioid, potentially worsening the problem by ... "Improved opioid analgesic effect following opioid dose reduction". Pain Med. 9 (6): 724-7. doi:10.1111/j.1526-4637.2008.00501. ...
... in daily doses of about 0.5 to 2 grams, although there are side-effects.[219] Excessive ingestion of lithium causes drowsiness ... The median lethal dose (LD50) value for caesium chloride in mice is 2.3 g per kilogram, which is comparable to the LD50 values ... "Low-dose lithium uptake promotes longevity in humans and metazoans". European Journal of Nutrition. 50 (5): 387-9. doi:10.1007 ...
2006 by the Neurology Division a dose was permitted for continuing a study in patients with Alzheimer's disease, but that dose ... and are only active at very high doses of 1000 mg or more. CX-717 and CX-1739 are newer and more potent drugs in the same ... the risks of longer-term use at higher doses, such as for treatment of ADHD, will be shown to be less than the FDA had ...
In preliminary human studies, oral intake of quercetin in doses up to one gram per day over three months did not cause adverse ... "Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on ...
... in smaller doses - due to tropane alkaloid content and is used by Chilean machi (shamans) of the Mapuche-Huilliche people in ... for a long or short time depending on the dose. It is considered with great secretiveness. Padre Romualdo, a missionary in ... Toro describes the machi conducting the ceremony drinking doses of a Latua infusion at 20 -30 minute intervals in order to ...
A lower dose may be required in the elderly. Quazepam is more tolerable for elderly patients compared to flurazepam due to its ... Roth TG, Roehrs TA, Koshorek GL, Greenblatt DJ, Rosenthal LD (October 1997). "Hypnotic effects of low doses of quazepam in ... Roth T, Tietz EI, Kramer M, Kaffeman M (1979). "The effect of a single dose of quazepam (Sch-16134) on the sleep of chronic ... Kales A, Scharf MB, Bixler EO, Schweitzer PK, Jacoby JA, Soldatos CR (August 1981). "Dose-response studies of quazepam". Clin. ...
Abruptly stopping the medication can thus result in acute and potentially life-threatening adrenal insufficiency and the dose ... patients never recover sufficient levels of internal production and must continue taking glucocorticoids at physiological doses ...
At doses of person above 100 mg/kg, necrosis of myocardial fibres may occur and areas of myocardial fibrosis can be observed in ... The lethal dose is not known; the effect is different depending upon the animal species. Mice: non-fatal injury to the ... High doses cause acute respiratory syndrome (asphyxia), with death approximately 12 to 24 hours after consumption. Lactating ...
What is the purpose of dose reconstruction? Dose reconstructions are used to estimate the radiation doses to which an ... Dose Reconstruction. What is dose reconstruction? Dose reconstruction is the scientific process of estimating a workers past ... How long does it take to complete a dose reconstruction? There are many steps necessary to complete each dose reconstruction, ... Once the dose reconstruction is completed by NIOSH, the case is returned to DOL. The information from the dose reconstruction ...
Recurrent cold sores: 1,500 mg as a single dose. *Suppression of recurrent genital herpes: 250 mg twice daily. ... Cases of kidney failure have been reported when higher than recommended doses of famciclovir were administered to patients with ...
Co-worker models can be used to reconstruct doses for unmonitored workers if the data are from the highest exposure group or a ... Final Rule: Methods for Radiation Dose Reconstruction under the Act-42 CFR 82 (Section 82.14, page 22333) pdf icon[129 KB (23 ... We understand the claimant may also have information that can help us estimate radiation dose. Each claimant can speak with us ... In this case, data on similar workers exposure is used for the dose reconstruction. Co-workers are workers at a site ( ...
Weekly AM/PM compartments help you to easily plan and distribute your daily doses and holds up to 30 pills per compartment ( ... Ezy Dose® Weekly AM/PM Push-Button Pill Organizer Make pill organizing easy and painless. Try the Ezy Dose AM/PM push-button ...
If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose ... Missed Dose. If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. ... Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle ... If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. ...
If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose ... Missed Dose. If you are prescribed this drug on a regular schedule (not just "as needed") and you miss a dose, take it as soon ... use this medication at the lowest effective dose for the shortest possible length of time. Do not increase your dose or take it ... However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81- ...
... recall of five batches of its childrens cough syrups because some packages contain an oral dosing cup with incorrect dose ... Posted in Health Concerns, Pharmaceuticals, Recalled Drugs , Tagged Childrens Cough Syrup, dosing cup, incorrect dosing, OTC, ... Tag Archives: dosing cup. This page is having a slideshow that uses Javascript. Your browser either doesnt support Javascript ... Childrens Cough Syrups Recalled Because of Incorrect Dosing Cup. Posted on January 14, 2016 by F.A. Kelley ...
Single-dose, repeat-dosing, and infusion regimens to achieve sedation level of less than 2 (arouses slowly to consciousness, ... Dosing increases with decreasing age. A large single dose is associated with deep sedation, possible adverse effects, and ... A smaller initial dose of 0.25 and 0.275, 0.3, and 0.35 mg/kg followed by an infusion 2.5 and 2.75, 3, and 3.5 mg/kg per hour ( ... Dosing ketamine for pediatric procedural sedation in the emergency department.. Dallimore D1, Herd DW, Short T, Anderson BJ. ...
Topi-Click Topical Dosing Applicator is the Continental Breakfast and Mid-day Break Sponsor at IACPs Educational Conference ... and tactile dosing feedback features of the Topi-Click allow patients to easily dispense a metered dose in a matter of seconds ... Topi-Click Topical Dosing Applicator is the Continental Breakfast and Mid-day Break Sponsor at IACPs Educational Conference ... The patented Topi-Click topical dosing applicator (TDA) combines an easy metering system for topical creams and gels with an ...
Each bottle contains enough doses for six people with a jab each.. ... Each bottle contains enough doses for six people with a jab each. ... the third week of March and they will return for a second dose ...
If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose ... Missed Dose. If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. ... Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle ... Do not increase your dose, take it more frequently, or use it for a longer time than directed. Improper use (abuse) of this ...
As this phenomenon has received little attention in the literature, dose modification has rarely been considered. However, with ... Augmented renal clearance: implications for antibacterial dosing in the critically ill.. Udy AA1, Roberts JA, Boots RJ, ... Although measurable endpoints can be used to titrate doses for many drugs in this setting (such as sedatives), for those agents ... consideration of ARC and alternative dosing regimens is now mandatory, both to improve the likelihood of treatment success and ...
Long-term use of high doses of vitamin B6 and B12 supplements has been associated with an increased risk for lung cancer in men ... "These are doses that can only be obtained from taking high-dose B vitamin supplements, and these supplements are many times the ... "If massive doses of individual supplements of B6 and B12 do indeed promote cancer, this is not the first time that mega doses ... Men who were smokers and who were taking B6 at this high dose were three times as likely - and male smokers taking B12 at this ...
Previous research has suggested that a small dose of aspirin may help prevent cancer. A new study explains why this may be true ... They also point out that the impact aspirin has on blood platelets is just as effective in high doses as it is at low ones. As ... Low-dose aspirin may be 'safe and efficacious' in preventing cancer This is the first time that a study has shown the ... New research reinforces the idea that low-dose aspirin intake may also help to prevent cancer and inhibit the proliferation of ...
But if youre not used to high doses like that, it may produce unpleasant GI symptoms. ... The Optimal Carbohydrate Dose For Endurance. The fastest times occurred when the subject had some, but not too much, ... The graph shows pretty much exactly what they were expecting to find: a "curvilinear dose-response" relationship. In other ...
BrightInsight announced the launch of a web-based CE-marked Dosing Calculator for emicizumab, a drug which is prescribed by ... The calculator aids physicians in determining the correct loading and maintenance dose of emicizumab that should be ... BrightInsight Announces the Launch of a CE-marked Dosing Calculator for Emicizumab ... The Hemlibra Dosing Calculator is a CE-marked SaMD intended for use by Health Care Professionals in Europe. ...
Antiretroviral agents are presently administered to adults in standard fixed doses. However, the same dose does not produce the ... Alternative Dosing Strategy for Anti-HIV Drugs. The safety and scientific validity of this study is the responsibility of the ... Anti-HIV drugs are usually given to patients at fixed, standardized doses. This study will investigate alternative ways of ... Recent research has shown that adjusting the doses of antiretroviral agents to achieve target concentrations in plasma is ...
... new research has found that kids and young adults starting on high doses of antidepressants are at especially high risk, ... Antidepressants & self-harm: For those under 24, initial dose matters Years after the Food and Drug Administration warned that ... It might also be that those started on high-dose SSRIs are more likely to discontinue their therapy and to suffer from " ... Given that antidepressants appear to be less effective in young people than in older patients, and that higher doses do not ...
When the total dose of radiation is divided into several, smaller doses over a period of several days, there are fewer toxic ... When the total dose of radiation is divided into several, smaller doses over a period of several days, there are fewer toxic ... dose. In the graph to the right, called a cell survival curve, the dose vs. surviving fraction have been drawn for a ... They have also found that if the radiation is fractionated into smaller doses, with one or more rest periods in between, fewer ...
2009 March nutraingredients news vitamin D vitamin_D dose doses dosing dosage winter nutrition supplements supplementation ... prevention mechanism UCTV University of California nutrition presentation lecture dosing dosage dose-response doses mechanisms ... 1 prevention nutrition dose-response dosing dosage diagnosis treatment list links ... 2009 July study review humans Vieth vitamin_D cancer dosage dosing UL risk assessment safety toxicity 25ohd calcidiol ...
Small doses of electricity delivered through a clothespin-like device clipped to a patients ear is being tested as a way to ... Lupus patients to get dose of electricity in Feinstein Institute test. A device clipped to a persons ear will deliver small ... Medical investigators there theorize that infinitesimal doses of electricity can be used to correct a vast number of medical ... Using electrical stimuli in tiny doses has already helped mitigate the pain and swelling associated with rheumatoid arthritis ...
Once-daily Gentamicin Dosing in Newborn Infants Faye S. Lundergan, BCNSP*‡§; Gregory F. Glasscock, Eun H. Kim, Ronald S. Cohen ...
Dosing The appropriate dose of graviola depends on several factors such as the users age, health, and several other conditions ... At this time there is not enough scientific information to determine an appropriate range of doses for graviola. Keep in mind ...
Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose ... Take your next dose at the regular time. Do not double the dose to catch up. ... To prevent motion sickness, take the first dose one hour before starting activity such as travel. ... Do not increase your dose or take this medication more often than directed. ...
Missed Dose If you miss a dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch ... Your dose may need to be gradually decreased.. A very serious high blood pressure reaction may rarely occur if you eat a large ... Do not increase your dose or take it more often than prescribed. Your condition will not improve any faster, and your risk of ... The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs. ...
If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose ... Missed Dose If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. ... Some liquid products need to be shaken before each dose. Some products that contain vitamin B12 need to be placed under the ... If you are taking a liquid product, use a medication-measuring device to carefully measure the dose. Do not use a household ...
Dosing The appropriate dose of caralluma depends on several factors such as the users age, health, and several other ... At this time there is not enough scientific information to determine an appropriate range of doses for caralluma. Keep in mind ...
Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose ... Take your next dose at the regular time. Do not double the dose to catch up. ... your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctors ... Ask your doctor or pharmacist how long to wait between doses and when you should take your medications. ...
Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose ... Take your next dose at the regular time. Do not double the dose to catch up. ... Buspirone may come in a tablet that can be split to get the correct dose for you. Follow the manufacturers Patient Instruction ... Buspirone will not prevent withdrawal symptoms from other medications, and your dose may need to be lowered slowly when you ...
If it is late in the afternoon or near the time of the next dose, skip the missed dose. Take your next dose at the regular time ... The first dose is usually taken when you wake up in the morning. If more doses are prescribed, take them as directed by your ... Missed Dose If you miss a dose, take it as soon as you remember in the morning hours. ... Your doctor may adjust your dose to find the dose that is best for you. Follow your doctors instructions carefully. ...
Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose ... Your doctor will start this medication at a low dose and gradually increase your dose. Any time your dose is increased or if ... Take your next dose at the regular time. Do not double the dose to catch up. See also How to Use section. ... If you miss taking terazosin for a few days, you may need to restart treatment at the low dose and gradually increase your dose ...
Dosing The appropriate dose of catuaba depends on several factors such as the users age, health, and several other conditions ... At this time there is not enough scientific information to determine an appropriate range of doses for catuaba. Keep in mind ...
If your dose is interrupted or stopped, contact your doctor right away to establish a new dosing schedule. ...
Dosing The appropriate dose of mallow depends on several factors such as the users age, health, and several other conditions. ... At this time there is not enough scientific information to determine an appropriate range of doses for mallow. Keep in mind ...
Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose ... Take your next dose at the regular time. Do not double the dose to catch up. ... Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for ... If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not ...
Missed Dose For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If ... you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule. ... These effects can occur during treatment with ipilimumab, but can also occur months after the last dose of this medication. ...
If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose ... Missed Dose If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. ... Place each dose on the tongue and allow to dissolve completely, then swallow it with saliva or with water. ... Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle ...
Missed Dose If you miss a dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch ... If the doses are not equal, take the larger dose at bedtime. ... If you miss 2 or more doses in a row, contact your doctor right ... your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctors ... The risk is greater if you have used this drug for a long time or in high doses, or if you are also taking a beta blocker (such ...
Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose ... Take your next dose at the regular time. Do not double the dose to catch up. ...
If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose ... Missed Dose If you are taking this product on a prescribed schedule and miss a dose, take it as soon as you remember. ... Ask your doctor or pharmacist about how long you should wait between doses and for help finding a dosing schedule that will ...
If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose ... Missed Dose If you are taking this product on a prescribed schedule and miss a dose, take it as soon as you remember. ... Ask your doctor or pharmacist about how long you should wait between doses and for help finding a dosing schedule that will ...
Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose ... Take your next dose at the regular time. Do not double the dose to catch up. ... Do not increase your dose or take it more often than prescribed. Do not stop taking this medication without your doctors ...
If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Do not double the dose to catch up. ... Missed Dose It is important to get each dose of this medication as scheduled. ... Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury ... Childrens dose is also based on weight. Follow your doctors instructions carefully. ...
The dose may need to be repeated in 5 to 10 minutes. This medication is for use in the eye only. Do not take by mouth or inject ... Repeat these steps if your dose is for more than 1 drop or for your other eye if so directed. ...
Dosing The appropriate dose of Pinellia ternata depends on several factors such as the users age, health, and several other ... At this time there is not enough scientific information to determine an appropriate range of doses for Pinellia ternata. Keep ...
Ten Doses of the Rebbes Vision The Divine Image of Man Meditations on Bitachon ... Subscribe and get your dose daily. To order Rabbi Freemans latest book, Wisdom to Heal the Earth, click here. ... Inspiration & Entertainment Daily Dose of Wisdom Wisdom To Heal the Earth Help From Within ...
Ten Doses of the Rebbes Vision The Divine Image of Man Meditations on Bitachon ... Subscribe and get your dose daily. To order Rabbi Freemans latest book, Wisdom to Heal the Earth, click here. ... Inspiration & Entertainment Daily Dose of Wisdom Wisdom To Heal the Earth Inner Wisdom ...
If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose ... Missed Dose If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. ... Place each dose on the tongue and allow to dissolve completely, then swallow it with saliva or with water. ... Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle ...
If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose ... Missed Dose If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. ... Some liquid products need to be shaken before each dose. Some products that contain vitamin B12 need to be placed under the ... If you are taking a liquid product, use a medication-measuring device to carefully measure the dose. Do not use a household ...
Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose ... Take your next dose at the regular time. Do not double the dose to catch up. ... For powder forms of this medication, measure each dose according to the directions on the product label. Mix in a full glass of ... Do not increase your dose or take this drug more often than directed. ...
  • Following staff nurse Susan Inglis inoculating her with her second dose of the Oxford/AstraZeneca vaccine, she celebrated being double vaccinated and urged people ensure they attend their appointments for second doses. (heraldscotland.com)
  • The SNP leader had her first dose of the Oxford/AstraZeneca vaccine at the same vaccination centre in on April 15. (heraldscotland.com)
  • MARTIN: The vaccines from Pfizer, Moderna and Johnson & Johnson will be in addition to the 60 million doses of the AstraZeneca vaccine promised once the FDA clears it for use. (npr.org)
  • The announcement comes on top of the Biden's administration's prior commitment to share about 60 million doses of the AstraZeneca vaccine, which is not yet authorized for use in the U.S., by the end of June. (nbcwashington.com)
  • The AstraZeneca doses will be available to ship once they clear a safety review by the Food and Drug Administration. (nbcwashington.com)
  • To date, the U.S. has shared about 4.5 million doses of AstraZeneca vaccine with Canada and Mexico. (nbcwashington.com)
  • In laboratory tests, blood from several dozen people given their first dose of the Pfizer or AstraZeneca vaccines "barely inhibited" the delta variant, the team reported in the journal Nature. (yahoo.com)
  • One dose of the Oxford-AstraZeneca vaccine provides sustained protection against Covid-19 for at least three months and cuts transmission of the virus by two-thirds. (irishtimes.com)
  • Japan recently announced the donation, through the COVAX facility, of 616,000 doses of the AstraZeneca vaccine manufactured in Japan for the people of Laos. (thestar.com.my)
  • PHE said the analysis was the first of its kind on the effectiveness of two doses of AstraZeneca in a real-world setting. (hindustantimes.com)
  • Two doses of the Oxford/AstraZeneca Covid-19 vaccine are around 85% to 90% effective against symptomatic disease, Public Health England (PHE) said on Thursday, citing an analysis of real-world data from the rollout of the shot. (hindustantimes.com)
  • This new data highlights the incredible impact that both doses of the vaccine can have, with a second dose of the Oxford/AstraZeneca vaccine providing up to 90% protection," vaccines minister Nadhim Zahawi said. (hindustantimes.com)
  • PHE said the analysis was the first of its kind on the effectiveness of two doses of AstraZeneca in a real-world setting but was not yet published in a journal, adding more data would boost its confidence in the finding. (hindustantimes.com)
  • Procurement Minister Anita Anand said Canada had so far received 29 million doses from Pfizer, Moderna Inc and AstraZeneca Plc. (financialpost.com)
  • The appropriate dose of graviola depends on several factors such as the user's age, health, and several other conditions. (webmd.com)
  • The appropriate dose of caralluma depends on several factors such as the user's age, health, and several other conditions. (webmd.com)
  • The appropriate dose of mallow depends on several factors such as the user's age, health, and several other conditions. (webmd.com)
  • As part of the deal, the Palestinian Authority will receive up to 1.4 million doses of the Pfizer-BioNTech vaccines that would have expired if left unused. (forbes.com)
  • From June 15 to 21 there were 1,228 Nunavummiut between the ages of 12 and 17 that received their first dose of Pfizer-BioNTech vaccine. (nunatsiaq.com)
  • France's health authority says people under 55 who received a first dose of AstraZeneca's vaccine should get the Pfizer/BioNTech or Moderna product for their second. (medpagetoday.com)
  • Julia Lorenti, 13, gets a dose of the Pfizer-BioNTech COVID-19 vaccine from Dr. Gary Bloch at a clinic for people with Indigenous ancestry in Toronto on May 25. (cbc.ca)
  • The plan to add the third dose of the vaccine comes after a report by the U.K.'s Medicines & Healthcare products Regulatory Agency (MHRA) reported that as of June 23, 2021, since the rollout of the vaccines in December, there have been 439 cases reported "suspected adverse reactions (ADRs) to the Pfizer/BioNTech vaccine in which the patient died shortly after vaccination. (lifesitenews.com)
  • The CDC tally includes two-dose vaccines from Moderna and Pfizer/BioNTech , as well as Johnson & Johnson's one-shot vaccine as of 6:00 a.m. (financialpost.com)
  • On Tuesday, PeaceHealth Southwest received 4,000 doses of the Pfizer-BioNTech COVID-19 vaccine. (columbian.com)
  • Youth are only eligible for doses of the Pfizer-BioNTech vaccine. (yahoo.com)
  • North Macedonia received another shipment of more than 100,000 doses of Pfizer-BioNTech vaccines through the COVAX system on Saturday. (wtrf.com)
  • Johnson & Johnson Covid-19 vaccine, Laos previously received a shipment of 132,000 doses of the Astra Zeneca-Oxford vaccines in March and a shipment of 100,620 doses of the Pfizer BioNTech vaccine in early June. (thestar.com.my)
  • By the end of September it expected to have received 51 million doses of the Pfizer/BioNTech vaccine alone, she added. (financialpost.com)
  • So far, 3,630,589 people in Scotland have received the first dose of a Covid-19 vaccination and 2,571,637 have received their second dose. (heraldscotland.com)
  • COVID-19 continues its swift decline in Haldimand-Norfolk, but first doses of the vaccine appear to have stalled. (yahoo.com)
  • New Delhi [India], July 20 (ANI): India administered more than 31.79 lakh COVID vaccine doses on Tuesday, taking the cumulative vaccination coverage to nearly 41.52 crores. (yahoo.com)
  • Madhya Pradesh, Maharashtra and Uttar Pradesh have administered more than 1 crore cumulative doses of COVID-19 Vaccine in the age group 18-44 years. (yahoo.com)
  • MANILA, Philippines - A batch of 1.5 million doses of the COVID-19 vaccine made by Chinese drugmaker Sinovac Biotech arrived in the country on Thursday morning. (philstar.com)
  • On Wednesday night, a shipment carrying 562,770 new doses of Pfizer's COVID-19 vaccine arrived in the country. (philstar.com)
  • Home ■ Health ■ COVID ■ Is a quarter-dose of Moderna vaccine enough? (cosmosmagazine.com)
  • According to a preprint study , two shots of the Moderna COVID-19 vaccine, each containing only one-quarter of the standard dose, generated neutralising antibodies and T cells comparable to natural infection. (cosmosmagazine.com)
  • President Joe Biden said Monday that the U.S. will share an additional 20 million doses of COVID-19 vaccines with the world in the coming six weeks as domestic demand for shots drops and global disparities in distribution have grown more evident. (nbcwashington.com)
  • Biden also tapped COVID-19 coordinator Jeff Zients to lead the administration's efforts to share doses with the world. (nbcwashington.com)
  • While wealthy countries continue ramping up vaccinations, less than 1 percent of COVID-19 vaccine doses globally have been administered to people in low-income countries," said Tom Hart the acting CEO of the ONE Campaign. (nbcwashington.com)
  • More than 157 million Americans have received at least one dose of a COVID-19 vaccine, and 123 million are full vaccinated against the virus. (nbcwashington.com)
  • Pfizer is about to seek U.S. authorization for a third dose of its COVID-19 vaccine, saying Thursday that another shot within 12 months could dramatically boost immunity and maybe help ward off the latest worrisome coronavirus mutant. (yahoo.com)
  • Israel on Friday reached an agreement to send between 1 to 1.4 million Covid-19 vaccine doses to the Palestinian Authority to help speed up vaccinations in the occupied West Bank and Gaza, a move that comes after Israel faced criticism for failing to offer equitable vaccine access to Palestinians living in the territories. (forbes.com)
  • Britain is on course to hit 15million first vaccine dose target by Valentine's Day as a further 494,163 Covid jabs are given. (dailymail.co.uk)
  • SINGAPORE - As of 4 March, more than 350,000 Singapore residents have received their first dose of the COVID-19 vaccine, said Health Minister Gan Kim Yong in Parliament on Friday (5 March). (yahoo.com)
  • Nunavut's COVID-19 vaccination campaign continues, having added 1,093 new first-doses in the past week. (nunatsiaq.com)
  • According to Government of Canada data, Nunavut still ranks last in the country for the percentage of the total population who have received at least one dose of a COVID-19 vaccine. (nunatsiaq.com)
  • But other experts say it's a confluence of factors that put Canada on track to become world leader in percentage of population with at least one dose of COVID-19 vaccine. (cbc.ca)
  • Canada has become a world leader when it comes to share of population with at least one dose of the COVID-19 vaccine. (cbc.ca)
  • But other experts note it's actually a confluence of factors that has put Canada on track to become the world leader when it comes to the share of its population inoculated with at least one dose of the COVID-19 vaccine. (cbc.ca)
  • Canada now among top countries for 1st doses of COVID-19 vaccines. (cbc.ca)
  • Third 'booster' dose will be offered in the UK this fall to 'prolong' the effect of the COVID vaccines, health authorities said. (lifesitenews.com)
  • The United States has administered 339,102,867 doses of COVID-19 vaccines in the country as of Wednesday morning and distributed 391,248,955 doses, the U.S. Centers for Disease Control and Prevention said. (financialpost.com)
  • TORONTO - Ontario youth aged 12 to 17 can move up their second COVID-19 vaccine doses next week as the province eyes the return to classrooms in September. (yahoo.com)
  • Toronto is launching a multi-pronged campaign to get the last 35 per cent of residents vaccinated against COVID-19, and to start getting second doses into those already partially protected. (thestar.com)
  • LONDON - Two doses of Pfizer or AstraZeneca's COVID-19 vaccine are nearly as effective against the highly transmissible Delta coronavirus variant as they are against the previously dominant Alpha variant, a study published on Wednesday showed. (inquirer.net)
  • Even as the Delhi government awaits the supply of extra doses to rollout the centralised vaccination drive in the Capital, citizens aged between 45 and 60 have been administered the most number of COVID vaccine doses in the city so far. (thehindu.com)
  • Healthcare workers, at almost 7%, were given the least number of COVID doses in the city followed by front-line workers who constitute around 11% of the total beneficiaries. (thehindu.com)
  • Almost 17% of the 18-44 age group, over 62% of the 45+ beneficiaries, over 82% of healthcare workers and over 72% of the population of front-line workers in the city have received at least one dose of COVID vaccination. (thehindu.com)
  • About 556,100 doses of COVID-19 vaccines have been administered to the public, with about 478,900 people receiving their first dose and about 77,200 people getting their second dose. (gov.hk)
  • Around 3,800 people received their first dose of the Sinovac vaccine under the COVID-19 Vaccination Programme today. (gov.hk)
  • Some Maryland hospitals have told officials they aren't getting enough second doses of the new COVID-19 vaccine. (wypr.org)
  • BELTON, Texas (KWTX) - Administration of second doses of the Pfizer COVID-19 vaccine in Bell County is expected to begin on Feb. 3 at a drive-thru site at the Bell County Expo Center, which will be open from 9 a.m. to 7 p.m. Monday to Thursday, health officials announced Thursday. (kwtx.com)
  • Residents must certify they received the first dose at one of the two county vaccination centers and must show their COVID-19 Vaccination Record when they arrive for their appointments. (kwtx.com)
  • VIENTIANE, July 17 (Vientiane Times/ANN): More than one million doses of the Johnson & Johnson Covid-19 vaccine donated by the government of the United States arrived in Vientiane late Friday evening (July 16). (thestar.com.my)
  • As of July 13, a total of 1,030,461 people in Laos had received the first dose of a Covid-19 vaccine, accounting for 14 percent of the population. (thestar.com.my)
  • The delivery of the vaccines comes after US President Joe Biden announced in June that the United States would purchase and donate 500 million doses of Covid-19 vaccines to 92 countries, including Laos. (thestar.com.my)
  • OTTAWA - Canada has negotiated an option with Pfizer Inc for an extra 3 million doses of its COVID-19 vaccine for delivery in September, Prime Minister Justin Trudeau told a briefing on Friday. (financialpost.com)
  • Fractionation of vaccine doses is a potential solution to this global shortage of vaccines that has not been given sufficient attention and consideration," they wrote. (cosmosmagazine.com)
  • On Wednesday, Tamil Nadu became 11th state in India to say it will opt for global tenders to get vaccines, even as officials in states said it wasn't clear by when they could receive doses. (hindustantimes.com)
  • With the unavailability of adequate vaccine doses from the Central government, the TMC has planned to buy the vaccines from the global markets. (hindustantimes.com)
  • The doses will come from existing production of Pfizer, Moderna or Johnson & Johnson vaccine stocks, marking the first time that U.S.-controlled doses of vaccines authorized for use in the country will be shared overseas. (nbcwashington.com)
  • He added that, compared to other countries like Russia and China that have sought to leverage their domestically produced doses, "we will not use our vaccines to secure favors from other countries. (nbcwashington.com)
  • Two doses of most vaccines are critical to develop high levels of virus-fighting antibodies against all versions of the coronavirus, not just the delta variant -- and most of the world still is desperate to get those initial protective doses as the pandemic continues to rage. (yahoo.com)
  • The Palestinians would then reciprocate by sending the same number of doses to Israel in September and October when they receive their share of the vaccines from the WHO's Covax initiative. (forbes.com)
  • CDPHE said they're expecting 45,500 doses of Janssen vaccines by Friday, but they treat all orders as estimates until they arrive. (koaa.com)
  • The Janssen vaccine requires only one dose, unlike the two-dose Moderna and Pfizer vaccines. (koaa.com)
  • The latest order of 500 000 doses of Sinopharm vaccines is now expected to arrive on Saturday, taking total deliveries of bought and donated vaccines to 2,26 million doses with more commercial orders already in the pipeline allowing a stepped-up vaccination programme. (zimbabwesituation.com)
  • Treasury set aside US$100 million for the procurement of vaccines and so far, 1,2 million Sinovac doses have been bought from China to add to 400 000 Sinopharm doses donated by China and the 100 000 Sinopharm doses from the from the Chinese People's Liberation Army for the Zimbabwe Defence Forces. (zimbabwesituation.com)
  • SKOPJE, North Macedonia (AP) - North Macedonia on Sunday received a shipment of 500,000 doses of Chinese Sinovac vaccines that will allow authorities to continue mass immunization in the country, which has slowed over the past two weeks because of vaccine shortages. (wtrf.com)
  • Health Minister Christian Dubé tweeted that the province's public health department still recommends people to wait eight weeks between doses of any of the three vaccines approved. (montrealgazette.com)
  • However, anyone who wishes to get the second dose early, must go to a walk-in clinic to do so, and must keep in mind the vaccines may not be as effective. (montrealgazette.com)
  • Among those receiving the first dose of vaccines, about 327,500 people have received the Sinovac jab and about 151,400 people have received the BioNTech one. (gov.hk)
  • Both vaccines available in the United States require two doses to be effective, and they need to be given either three or four weeks apart, depending on which vaccine it is. (wypr.org)
  • Criticising the Centre for 'not providing' enough vaccine doses to the state, the Chief Minister said, "We have no vaccines for which we are only administering the second dose now. (siasat.com)
  • The plane carrying 1.5 million doses for Sinovac arrived in the country on Thursday morning. (philstar.com)
  • It added that another one million doses of Sinovac will arrive at the Ninoy Aquino International Airport on Friday. (philstar.com)
  • For the second dose, about 76,600 people have received the Sinovac vaccine while about 600 people have been administered the BioNTech jab. (gov.hk)
  • Around 7,600 people received their second dose of the Sinovac vaccine today, including about 6,800 people vaccinated at CVCs and about 800 people through private doctors and clinics. (gov.hk)
  • As of 8pm, about 2,300 people had reserved their first and second doses of the Sinovac vaccine online, while about 15,900 had reserved their first and second doses of the BioNTech vaccine. (gov.hk)
  • Please roll up your sleeve for both doses as soon as you are invited for an appointment - every single one of us who gets fully vaccinated is a step back to normality for all of us. (heraldscotland.com)
  • To date, 16,116 have received two doses and are either fully vaccinated or soon will be. (nunatsiaq.com)
  • The agency said 186,819,440 people had received at least one dose while 161,895,045 people are fully vaccinated as of Wednesday. (financialpost.com)
  • The province says 77 per cent of adults have received at least one dose and more than 42 per cent are fully vaccinated. (yahoo.com)
  • By Sunday night 435 668 people had been fully vaccinated with both doses, and with another 267 397 people having had their first dose and now awaiting their second dose. (zimbabwesituation.com)
  • Prime Minister Boris Johnson's government announced in a press release on June 30, 2021, that they have "welcomed the interim advice" of the Joint Committee on Vaccination and Immunisation (JCVI) and will prepare to roll out a booster dose of the vaccine this fall. (lifesitenews.com)
  • The civic body has a budget of ₹ 50 crore for the buying of these five lakh vaccine doses. (hindustantimes.com)
  • This is very important in India since around 17-18 crore people have received only one dose, while around 4 crore people have received two doses," he said. (assamtribune.com)
  • Speaking to the media, Banerjee said, "We have administered 2.17 crore vaccine doses so far of which 18 lakh vials worth Rs 59 crore have been procured by the state government directly from the manufacturers. (siasat.com)
  • We have received 1.99 crore doses from the Centre of which 1.90 core have been administered. (siasat.com)
  • Uttar Pradesh has received 3.15 crore doses, Maharashtra has got 3.17 crore doses, but we have been left out. (siasat.com)
  • The population of residents in the 18-44 category is estimated at 92 lakh among which 17,91,758 doses have been administered. (thehindu.com)
  • The population of citizens in the 45-plus category - including beneficiaries falling in both the 45-60 and 60-plus age groups - is estimated at 57 lakh among whom 36,59,191 doses have been administered. (thehindu.com)
  • In fact, for those who received Moderna and Pfizer for their first dose, they only have to wait a minimum of 21 days, because that is the minimum wait times subscribed by the province's vaccination committee. (montrealgazette.com)
  • The First Minister became one of the more than two million Scots to have two doses, on being vaccinated at the NHS Louisa Jordan vaccination centre at the SSE Hydro in Glasgow on Monday. (heraldscotland.com)
  • The April 19 decision allowed vaccine manufacturers in India to supply 50% of monthly output to states and private hospitals after keeping 50% of doses for the Centre. (hindustantimes.com)
  • While the Delhi government blamed the Centre for not providing adequate doses to the city for the universal vaccine drive, former North Corporation Mayor Jai Prakash, at a vaccination centre on the premises of the Bara Hindu Rao Hospital welcomed walk-in vaccine beneficiaries with a band and refreshments. (thehindu.com)
  • West Bengal Chief Minister Mamata Banerjee on Wednesday took a jibe at the Centre over the suspended supply of vaccine doses to the state, alleging that when other states are getting more vials, Bengal is being overlooked though the state has performed exceptionally in implementing the vaccine scheme. (siasat.com)
  • It also makes it look like the hospitals did not use all of their assigned first doses because they did not administer as many first doses as the state was expecting. (wypr.org)
  • While those numbers include vaccinations given to non-residents, such as rotational workers, the Government of Nunavut has not identified the number of those doses. (nunatsiaq.com)
  • His frequent praise for Canada can be found on Twitter, including a recent tweet lauding the country for 'pulling away, setting a new pace and ceiling for 1st dose vaccinations of major countries. (cbc.ca)
  • When NTAGI took this decision, we also decided that India will establish a vaccine tracking platform - to assess not only the impact of vaccination programme, but also type of vaccine and interval between doses, and what happens when someone is fully/ partially immunized. (assamtribune.com)
  • Last week, Britain cut the gap between doses down to 8 weeks for the over 50s, aiming to give maximum protection to more vulnerable people in light of concern about the B.1.617.2 variant first found in India. (hindustantimes.com)
  • President Biden announced yesterday the planned shipment of 20 million doses of coronavirus vaccine abroad to countries in need. (npr.org)
  • An Indian woman is injected with a dose of COVAXIN as she gets vaccinated against the coronavirus in Gauhati, Assam. (hindustantimes.com)
  • The 1,008,000 doses of Johnson & Johnson's Janssen vaccine will be used by the Lao government to provide protection against the Coronavirus to more than one million people, representing about 14 percent of the total population, as it only requires only a single dose. (thestar.com.my)
  • Israel is to bolster the Palestinian vaccination drive, trading a million doses. (forbes.com)
  • Do not increase your dose or take this medication more often than directed. (webmd.com)
  • If you are taking a liquid product, use a medication-measuring device to carefully measure the dose. (webmd.com)
  • To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. (webmd.com)
  • If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. (webmd.com)
  • Your doctor will start this medication at a low dose and gradually increase your dose. (webmd.com)
  • These effects can occur during treatment with ipilimumab, but can also occur months after the last dose of this medication. (webmd.com)
  • For powder forms of this medication, measure each dose according to the directions on the product label. (webmd.com)
  • If you vomit within 2 hours of taking this medication, contact your doctor to ask if you need to repeat the dose. (webmd.com)
  • I take Citalopram and when i started out (@ 20mg), i had debilitating depression, after taking the medication for 3 weeks my doctor ordered a dose increase (to 40mg) and i felt better almost immediately. (drugs.com)
  • Dr. Adam Kassam, president of the association, said he was encouraged by the news of expanded access to a shortened interval between doses for youth. (yahoo.com)
  • Some countries like the UK went for a dose interval of 12 weeks when they introduced the vaccine in December 2020, he said. (assamtribune.com)
  • The sooner the US and other wealthy countries develop a coordinated strategy for sharing vaccine doses with the world's most vulnerable, the faster we will end the global pandemic for all. (nbcwashington.com)
  • We have older scanners in my office - 4-slice, 8-slice, and so on - and I didn't want to spend the $90,000 to $100,000 on technology with low-dose characteristics built in," said Robins, who is also IHS's heart imaging medical director. (diagnosticimaging.com)
  • Norfolk EMS chief and vaccine task force lead Sarah Page said appointments at all clinics continue to fill up "quite rapidly," pointing out some people under 40 only recently became eligible for their first dose. (yahoo.com)
  • Some people do better on a lower dose. (drugs.com)
  • A vaccine dose-reduction approach was successfully adopted in 2016 when limited supplies of a vaccine that took a minimum of 6 months to manufacture left millions of people in Africa and South America vulnerable to an epidemic of yellow fever. (cosmosmagazine.com)
  • Giving another dose would be "a huge effort while we are at the moment striving to get people the first dose. (yahoo.com)
  • 8%. That's the percentage of people living in the Palestinian territories who have received at least one dose of the vaccine so far, according to Reuters' global vaccination tracker . (forbes.com)
  • More than 21,000 people in Nunavut have received at least one vaccine dose, Premier Joe Savikataaq announced on Twitter on Monday. (nunatsiaq.com)
  • By that date, an average of 188,000 people were receiving a dose every day in Canada: a figure that is now at 375,000, or one per cent of the country's population, he said. (cbc.ca)
  • Nearly 25% of the country's 2.1 million people have been vaccinated with at least one dose so far. (wtrf.com)
  • He said people "would be lucky" to receive a vaccination in this way, as centres are managing their doses efficiently to allow for those who do not attend. (broadsheet.ie)
  • Dr. Eileen de Villa, Toronto's public health chief, noted about 20 per cent of people aged 80 and older still have not received their first dose, adding that number could drop if the province makes vaccine more widely available through physicians' offices. (thestar.com)
  • The people who got their first doses four weeks ago were primarily frontline healthcare workers, in the state's Phase 1A. (wypr.org)
  • The health department is in touch with the people who have taken the fake doses and the government will vaccinate them again. (siasat.com)
  • Some 647,872 people have got two doses, equal to 8 percent of the population. (thestar.com.my)
  • Clinical trials aiming to confirm the efficacy of reduced vaccine doses are ongoing. (cosmosmagazine.com)
  • There are several studies comparing low dosing with high/standard dosing, and they all pretty much have the same efficacy and remission rates, of course with the lower dosage there are far fewer nasty side effects. (healthboards.com)
  • According to the FDA, the single-dose vaccine has an efficacy rate of around 72% in the U.S., and an efficacy rate of around 86% when it comes to preventing severe forms of the disease. (koaa.com)
  • He also cited that the increase in gap between two doses was based on studies that showed higher efficacy with increase in gap. (assamtribune.com)
  • On the protection from single dose versus two doses, Dr Arora explained how emerging evidence and reports regarding efficacy of partial versus full immunization were being considered by NTAGI. (assamtribune.com)
  • Britain extended the gap between doses to 12 weeks, though Pfizer warned there was a lack of evidence of its efficacy outside the three-week gap used in trials. (hindustantimes.com)
  • One dose, I would say, is going to very likely massively change the epidemiological situation in the country,' said one expert in response to the Conservative's now-deleted tweet. (globalnews.ca)
  • Boris Johnson is on course to hit his target of 15 million first vaccine doses by Valentine's Day. (dailymail.co.uk)
  • So far, there is no meltdown.The city of Cincinnati administered 1,000 doses of Johnson & Johnson this past Sunday. (wlwt.com)
  • Nothing else with that vaccine was scheduled for the rest of the week.The city is using either Pfizer or Moderna at the Duke Energy Convention Center and has had comparatively little Johnson & Johnson.According to the health department, there were a total of 55,475 Pfizer doses administered so far along with 7,890 Moderna doses and 1,712 Johnson & Johnson vaccine.TriHealth has pulled its doses of Johnson & Johnson as well. (wlwt.com)
  • Additional doses of the Pfizer vaccine manufactured in the U.S. have begun to be exported as the company has met its initial contract commitments to the federal government. (nbcwashington.com)
  • In a later study , Moderna scientists found that two half-dose jabs elicited an immune response as good as the standard dose. (cosmosmagazine.com)
  • If you miss taking terazosin for a few days, you may need to restart treatment at the low dose and gradually increase your dose again. (webmd.com)
  • Do not increase your dose or take this drug more often than directed. (webmd.com)
  • The dose of your warfarin (Coumadin) might need to be changed. (medicinenet.com)
  • Some 200 million doses will be delivered by the end of this year and the remaining 300 million will be delivered in the first half of 2022. (thestar.com.my)
  • Buspirone may come in a tablet that can be split to get the correct dose for you. (webmd.com)
  • Do not use a household spoon because you may not get the correct dose. (webmd.com)
  • It's up to the CarnoSyn brand partners to formulate their supplements with the correct dose of the ingredient. (nutritionaloutlook.com)
  • The Palestinians have so far received vaccine doses from Israel, Russia, China, the United Arab Emirates and the Covax initiative. (forbes.com)
  • The advice on the forum was very valuable, and after learning the recommended guinea pig bactrim dosage, I was able to weigh him, figure his dose, and he got all better. (guinealynx.com)
  • Your dose may need to be gradually decreased. (webmd.com)
  • To prevent any reactions while you are stopping treatment with this drug, your doctor may reduce your dose gradually. (webmd.com)
  • When you reduced your doses do you do it gradually or just go down 10 mg and you are ok? (drugs.com)
  • Follow the manufacturer's Patient Instruction Sheet or ask your pharmacist how to split the tablet to get your dose. (webmd.com)
  • While before it might have taken you several days to produce a few product variants, with aseptic dosing it can be done in a single day. (tetrapak.com)
  • The large share of North America can be attributed to factors such as the stringent legislative and accreditation requirements regarding the reporting and optimization of radiation doses, high adoption of HCIT technologies, and the presence of stringent regulatory requirements regarding patient safety. (marketsandmarkets.com)
  • This is pushing for a level of scanning protocol optimization and dose personalization that we have not seen before.While most CT scanners do a good job of reporting the amount of energy they emit, it often takes sophisticated analysis to determine what this means at a personalized level to each patient. (appliedradiology.com)
  • The full study published on Wednesday found that one dose of Pfizer's shot was 36% effective, and one dose of AstraZeneca's vaccine was around 30% effective. (inquirer.net)
  • Is 20mg too high of a dose for some? (drugs.com)
  • He wanted to start me off at 70mg, but all of the literature states that that's WAY too high of a dose. (healthboards.com)
  • I've been taking 20mg daily and still experiencing some flushing of my cheeks etc. 70mg would have been way too high of a dose for me. (healthboards.com)
  • Officials hope to deliver as many as 100 doses an hour. (kwtx.com)
  • We offer dosing equipment for inline continuous processing, which permits greater flexibility than batch systems. (tetrapak.com)
  • But, again, I think our finding is when we talk to our partners in the G-7, when we talk to other partners around the world, there is a real desire and commitment to sharing more doses. (npr.org)
  • Our center made a commitment a few years back to offer the lowest dose CT scans we could. (diagnosticimaging.com)
  • The growth in this market is attributed to the increasing use of medical imaging modalities due to the rising incidence of chronic diseases, increasing concerns over radiation dose exposure, growth in the installed base of radiology equipment, and growing awareness on radiation dose management. (marketsandmarkets.com)
  • On the basis of product & service, the radiation dose management market is segmented into radiation dose management solutions and radiation dose management services. (marketsandmarkets.com)
  • The large share of this segment can be attributed to the increasing adoption of radiation dose management solutions by healthcare providers owing to the growing regulations regarding ionizing radiation across the globe. (marketsandmarkets.com)
  • Based on application, the radiation dose management market is segmented into oncology, cardiology, orthopaedic application and other application. (marketsandmarkets.com)
  • This has resulted in the rising adoption of imaging techniques for cancer detection and treatment planning, thus driving the demand for radiation dose management software as well. (marketsandmarkets.com)
  • Based on end users, the radiation dose management market is segmented into hospitals, ambulatory care settings, and other end users. (marketsandmarkets.com)
  • The rising patient population, growing awareness about the benefits of early disease diagnosis, technological advancements in imaging modalities, and the increasing awareness of the harmful effects of radiation exposure are some of the major factors responsible for the high demand for radiation dose management solutions in hospitals. (marketsandmarkets.com)
  • The radiation dose management market is segmented into four major regional segments, namely, North America, Europe, Asia Pacific, and the Rest of the World. (marketsandmarkets.com)
  • In 2018, North America accounted for the largest share of the radiation dose management market. (marketsandmarkets.com)
  • The major players in the radiation dose management market are Bayer AG (Germany), GE Healthcare (US), PACSHealth, LLC (US), and Sectra Medical Systems (Sweden). (marketsandmarkets.com)
  • Don t miss out on business opportunities in Radiation Dose Management Market. (marketsandmarkets.com)
  • While the trajectory in the growth of CT volume is not as steep as the double-digit growth experienced in the 2000s, the continued upward trend in usage and the direct correlation to increased risk of cancer opens up CT radiation dose management to many opportunities to find the perfect balance between the acceptance of the risks associated with radiation versus the benefits to be gained from the use of radiation. (appliedradiology.com)
  • While the ultimate goal is a personalized approach to radiation dose management, we have to start with the basics. (appliedradiology.com)
  • While airport scanners are worthy catalysts for debate on radiation dose management, the reality is that these are, in the larger scheme of things, quite harmless. (appliedradiology.com)
  • This kind of study helps scientists determine the dose that triggers the best immune response with the lowest side effects. (cosmosmagazine.com)
  • Have read a post on here back in 2009 from LowTane (tried to connect with him, but not sure how yet) who had what sounds to be a more severe form of rosacea than I, but he had excellent results taking low dose accutane (beginning at 20mg/day) and eventually getting down to 10mg/week. (healthboards.com)