A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Drugs used to prevent NAUSEA or VOMITING.
The forcible expulsion of the contents of the STOMACH through the MOUTH.
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
A dopamine D2 antagonist that is used as an antiemetic.
Emesis and queasiness occurring after anesthesia.
A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
Isonipecotic acids are a group of organic compounds that are structurally similar to nicotinic acid, with a pyridine ring substituted at the 2-position by a carboxylic acid group, and can act as inhibitors of monoamine oxidase enzymes.
A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
A subclass of serotonin receptors that form cation channels and mediate signal transduction by depolarizing the cell membrane. The cation channels are formed from 5 receptor subunits. When stimulated the receptors allow the selective passage of SODIUM; POTASSIUM; and CALCIUM.
Symptoms of NAUSEA and VOMITING in pregnant women that usually occur in the morning during the first 2 to 3 months of PREGNANCY. Severe persistent vomiting during pregnancy is called HYPEREMESIS GRAVIDARUM.
Quinuclidines are organic compounds consisting of a tricyclic structure with a three-membered ring fused to a piperidine ring, often used as building blocks in the synthesis of pharmaceuticals and bioactive molecules.
A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
An anti-inflammatory 9-fluoro-glucocorticoid.
Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.
Quinolizines are heterocyclic organic compounds containing a bicyclic structure formed by a benzene ring fused to a piperidine ring, which have been used as building blocks in the synthesis of various pharmaceuticals and bioactive molecules.
Agents, usually topical, that relieve itching (pruritus).
A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Intractable VOMITING that develops in early PREGNANCY and persists. This can lead to DEHYDRATION and WEIGHT LOSS.
Injections made into a vein for therapeutic or experimental purposes.
Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
The giving of drugs, chemicals, or other substances by mouth.
Surgery performed on the female genitalia.
Therapy with two or more separate preparations given for a combined effect.
Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.
Misalignment of the visual axes of the eyes. In comitant strabismus the degree of ocular misalignment does not vary with the direction of gaze. In noncomitant strabismus the degree of misalignment varies depending on direction of gaze or which eye is fixating on the target. (Miller, Walsh & Hoyt's Clinical Neuro-Ophthalmology, 4th ed, p641)
Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.
Drugs administered before an anesthetic to decrease a patient's anxiety and control the effects of that anesthetic.
L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.
Surgical removal of a tonsil or tonsils. (Dorland, 28th ed)

Ondansetron is a medication that is primarily used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, or surgery. It is a selective antagonist of 5-HT3 receptors, which are found in the brain and gut and play a role in triggering the vomiting reflex. By blocking these receptors, ondansetron helps to reduce the frequency and severity of nausea and vomiting.

The drug is available in various forms, including tablets, oral solution, and injection, and is typically administered 30 minutes before chemotherapy or surgery, and then every 8 to 12 hours as needed. Common side effects of ondansetron include headache, constipation, and diarrhea.

It's important to note that ondansetron should be used under the supervision of a healthcare provider, and its use may be contraindicated in certain individuals, such as those with a history of allergic reactions to the drug or who have certain heart conditions.

Antiemetics are a class of medications that are used to prevent and treat nausea and vomiting. They work by blocking or reducing the activity of dopamine, serotonin, and other neurotransmitters in the brain that can trigger these symptoms. Antiemetics can be prescribed for a variety of conditions, including motion sickness, chemotherapy-induced nausea and vomiting, postoperative nausea and vomiting, and pregnancy-related morning sickness. Some common examples of antiemetic medications include ondansetron (Zofran), promethazine (Phenergan), and metoclopramide (Reglan).

Vomiting is defined in medical terms as the forceful expulsion of stomach contents through the mouth. It is a violent, involuntary act that is usually accompanied by strong contractions of the abdominal muscles and retching. The body's vomiting reflex is typically triggered when the brain receives signals from the digestive system that something is amiss.

There are many potential causes of vomiting, including gastrointestinal infections, food poisoning, motion sickness, pregnancy, alcohol consumption, and certain medications or medical conditions. In some cases, vomiting can be a symptom of a more serious underlying condition, such as a brain injury, concussion, or chemical imbalance in the body.

Vomiting is generally not considered a serious medical emergency on its own, but it can lead to dehydration and other complications if left untreated. If vomiting persists for an extended period of time, or if it is accompanied by other concerning symptoms such as severe abdominal pain, fever, or difficulty breathing, it is important to seek medical attention promptly.

Nausea is a subjective, unpleasant sensation of discomfort in the stomach and upper gastrointestinal tract that may precede vomiting. It's often described as a feeling of queasiness or the need to vomit. Nausea can be caused by various factors, including motion sickness, pregnancy, gastrointestinal disorders, infections, certain medications, and emotional stress. While nausea is not a disease itself, it can be a symptom of an underlying medical condition that requires attention and treatment.

Serotonin antagonists are a class of drugs that block the action of serotonin, a neurotransmitter, at specific receptor sites in the brain and elsewhere in the body. They work by binding to the serotonin receptors without activating them, thereby preventing the natural serotonin from binding and transmitting signals.

Serotonin antagonists are used in the treatment of various conditions such as psychiatric disorders, migraines, and nausea and vomiting associated with cancer chemotherapy. They can have varying degrees of affinity for different types of serotonin receptors (e.g., 5-HT2A, 5-HT3, etc.), which contributes to their specific therapeutic effects and side effect profiles.

Examples of serotonin antagonists include ondansetron (used to treat nausea and vomiting), risperidone and olanzapine (used to treat psychiatric disorders), and methysergide (used to prevent migraines). It's important to note that these medications should be used under the supervision of a healthcare provider, as they can have potential risks and interactions with other drugs.

Metoclopramide is a medication that is primarily used to manage gastrointestinal disorders. It is classified as a dopamine antagonist and a prokinetic agent, which means it works by blocking the action of dopamine, a chemical in the brain that can slow down stomach and intestine function.

The medical definition of Metoclopramide is:
A synthetic congener of procainamide, used as an antiemetic and to increase gastrointestinal motility. It has a antidopaminergic action, binding to D2 receptors in the chemoreceptor trigger zone and stomach, and it may also block 5HT3 receptors at intrapyloric and central levels. Its actions on the gut smooth muscle are mediated via cholinergic muscarinic receptors. (Source: Dorland's Medical Dictionary)

Metoclopramide is commonly used to treat conditions such as gastroesophageal reflux disease (GERD), gastritis, and gastroparesis, which is a condition that affects the normal movement of food through the digestive tract. It can also be used to prevent nausea and vomiting caused by chemotherapy or radiation therapy.

Like any medication, Metoclopramide can have side effects, including drowsiness, restlessness, and muscle spasms. In some cases, it may cause more serious side effects such as tardive dyskinesia, a condition characterized by involuntary movements of the face, tongue, or limbs. It is important to use Metoclopramide only under the supervision of a healthcare provider and to follow their instructions carefully.

Postoperative nausea and vomiting (PONV) are common complications following surgical procedures. It is defined as nausea, vomiting, or both that occurs within the first 24 hours after surgery. PONV can lead to dehydration, electrolyte imbalances, wound dehiscence, and impaired patient satisfaction. Risk factors for PONV include female gender, non-smoking status, history of motion sickness or PONV, use of opioids, and longer duration of surgery. Preventive measures and treatments include antiemetic medications, fluid therapy, and acupuncture or acupressure.

Droperidol is a butyrophenone neuroleptic medication that is primarily used for its antiemetic (anti-nausea and vomiting) properties. It works by blocking dopamine receptors in the brain, which can help to reduce feelings of nausea and vomiting caused by various factors such as chemotherapy, surgery, or motion sickness.

Droperidol is also known for its sedative and anxiolytic (anxiety-reducing) effects, and has been used in the past as a premedication before surgery to help reduce anxiety and produce sedation. However, due to concerns about rare but serious side effects such as QT prolongation (a heart rhythm disorder), droperidol is now less commonly used for this purpose.

Droperidol is available in injectable form and is typically administered by healthcare professionals in a hospital or clinical setting. It should be used with caution and only under the close supervision of a healthcare provider, as it can cause a range of side effects including dizziness, drowsiness, dry mouth, and restlessness. More serious side effects such as seizures, irregular heartbeat, and neuroleptic malignant syndrome (a rare but potentially life-threatening condition characterized by muscle rigidity, fever, and autonomic instability) have also been reported with droperidol use.

Iso Nipecotic Acids are a type of organic compound that are structurally related to nipecotic acid, which is a GABAergic agent. Iso Nipecotic Acids have a similar chemical structure to nipecotic acid, but with the position of the amino group and the carboxylic acid group reversed.

These compounds are known to act as potent and selective antagonists at certain subtypes of nicotinic acetylcholine receptors (nAChRs), which are important targets for the development of drugs for various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia.

Iso Nipecotic Acids have been used in research to study the role of nAChRs in the brain and to investigate their potential as therapeutic agents for various neurological disorders. However, it is important to note that these compounds are not approved for use in humans and should only be used in a controlled laboratory setting under the guidance of trained researchers.

Granisetron is a medication that is primarily used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, or surgery. It belongs to a class of drugs known as serotonin antagonists, which work by blocking the action of serotonin, a chemical in the brain that can trigger nausea and vomiting.

Granisetron is available in several forms, including oral tablets, oral solution, and injectable solutions. It is usually taken or administered about an hour before chemotherapy or radiation therapy, or shortly before surgery. The medication may also be given as needed to manage nausea and vomiting that occur after these treatments.

Common side effects of granisetron include headache, constipation, dizziness, and tiredness. In rare cases, it can cause more serious side effects such as irregular heartbeat, seizures, or allergic reactions. It is important to follow the dosage instructions carefully and inform your healthcare provider if you experience any unusual symptoms while taking granisetron.

Serotonin 5-HT3 receptor antagonists are a class of medications that work by blocking the serotonin 5-HT3 receptors, which are found in the gastrointestinal tract and the brain. These receptors play a role in regulating nausea and vomiting, among other functions.

When serotonin binds to these receptors, it can trigger a series of events that lead to nausea and vomiting, particularly in response to chemotherapy or surgery. By blocking the 5-HT3 receptors, serotonin cannot bind to them and therefore cannot trigger these events, which helps to reduce nausea and vomiting.

Examples of 5-HT3 receptor antagonists include ondansetron (Zofran), granisetron (Kytril), palonosetron (Aloxi), and dolasetron (Anzemet). These medications are commonly used to prevent and treat nausea and vomiting associated with chemotherapy, radiation therapy, and surgery.

The double-blind method is a study design commonly used in research, including clinical trials, to minimize bias and ensure the objectivity of results. In this approach, both the participants and the researchers are unaware of which group the participants are assigned to, whether it be the experimental group or the control group. This means that neither the participants nor the researchers know who is receiving a particular treatment or placebo, thus reducing the potential for bias in the evaluation of outcomes. The assignment of participants to groups is typically done by a third party not involved in the study, and the codes are only revealed after all data have been collected and analyzed.

'Receptors, Serotonin, 5-HT3' refer to a specific type of serotonin receptor called the 5-HT3 receptor, which is a ligand-gated ion channel found in the cell membrane. Serotonin, also known as 5-hydroxytryptamine (5-HT), is a neurotransmitter that plays a role in various physiological functions, including mood regulation, appetite control, and nausea.

The 5-HT3 receptor is activated by serotonin and mediates fast excitatory synaptic transmission in the central and peripheral nervous systems. It is permeable to sodium (Na+), potassium (K+), and calcium (Ca2+) ions, allowing for the rapid depolarization of neurons and the initiation of action potentials.

The 5-HT3 receptor has been a target for drug development, particularly in the treatment of chemotherapy-induced nausea and vomiting, as well as irritable bowel syndrome. Antagonists of the 5-HT3 receptor, such as ondansetron and granisetron, work by blocking the receptor and preventing serotonin from activating it, thereby reducing symptoms of nausea and vomiting.

Morning sickness is a common condition during pregnancy, typically characterized by nausea and vomiting. It usually occurs in the morning, although it can happen at any time of the day. The exact cause is not known, but it's thought to be due to the hormonal changes that occur during early pregnancy. For most women, morning sickness improves or goes away after the first trimester. However, for some, it may last longer. While it can be unpleasant and uncomfortable, morning sickness is generally not harmful to the mother or baby, unless it's severe and leads to dehydration or weight loss. In such cases, medical attention is required.

Quinuclidines are a class of organic compounds that contain a unique cage-like structure consisting of a tetrahydrofuran ring fused to a piperidine ring. The name "quinuclidine" is derived from the Latin word "quinque," meaning five, and "clidis," meaning key or bar, which refers to the five-membered ring system that forms the core of these compounds.

Quinuclidines have a variety of biological activities and are used in pharmaceuticals as well as agrochemicals. Some quinuclidine derivatives have been found to exhibit anti-inflammatory, antiviral, and anticancer properties. They can also act as inhibitors of various enzymes and receptors, making them useful tools for studying biological systems and developing new drugs.

It is worth noting that quinuclidines are not typically used in medical diagnosis or treatment, but rather serve as building blocks for the development of new pharmaceutical compounds.

Prochlorperazine is an antipsychotic drug, specifically a phenothiazine derivative. It works by blocking dopamine receptors in the brain, which helps to reduce psychotic symptoms such as hallucinations and delusions, and also has antiemetic (anti-nausea and vomiting) effects.

Prochlorperazine is used to treat various conditions, including:

* Schizophrenia and other psychotic disorders
* Nausea and vomiting, including motion sickness and postoperative nausea and vomiting
* Severe anxiety or agitation
* Tension headaches

The drug can be administered orally, intramuscularly, or rectally, depending on the formulation. Common side effects of prochlorperazine include drowsiness, dry mouth, blurred vision, and constipation. More serious side effects can include neurological symptoms such as tardive dyskinesia (involuntary movements), neuroleptic malignant syndrome (a life-threatening condition characterized by fever, muscle rigidity, and autonomic dysfunction), and seizures. Prochlorperazine should be used with caution in elderly patients, those with a history of seizures or cardiovascular disease, and those taking other medications that may interact with it.

Dexamethasone is a type of corticosteroid medication, which is a synthetic version of a natural hormone produced by the adrenal glands. It is often used to reduce inflammation and suppress the immune system in a variety of medical conditions, including allergies, asthma, rheumatoid arthritis, and certain skin conditions.

Dexamethasone works by binding to specific receptors in cells, which triggers a range of anti-inflammatory effects. These include reducing the production of chemicals that cause inflammation, suppressing the activity of immune cells, and stabilizing cell membranes.

In addition to its anti-inflammatory effects, dexamethasone can also be used to treat other medical conditions, such as certain types of cancer, brain swelling, and adrenal insufficiency. It is available in a variety of forms, including tablets, liquids, creams, and injectable solutions.

Like all medications, dexamethasone can have side effects, particularly if used for long periods of time or at high doses. These may include mood changes, increased appetite, weight gain, acne, thinning skin, easy bruising, and an increased risk of infections. It is important to follow the instructions of a healthcare provider when taking dexamethasone to minimize the risk of side effects.

Serotonin receptors are a type of cell surface receptor that bind to the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). They are widely distributed throughout the body, including the central and peripheral nervous systems, where they play important roles in regulating various physiological processes such as mood, appetite, sleep, memory, learning, and cognition.

There are seven different classes of serotonin receptors (5-HT1 to 5-HT7), each with multiple subtypes, that exhibit distinct pharmacological properties and signaling mechanisms. These receptors are G protein-coupled receptors (GPCRs) or ligand-gated ion channels, which activate intracellular signaling pathways upon serotonin binding.

Serotonin receptors have been implicated in various neurological and psychiatric disorders, including depression, anxiety, schizophrenia, and migraine. Therefore, selective serotonin receptor agonists or antagonists are used as therapeutic agents for the treatment of these conditions.

Quinolizines are not a medical term, but a chemical classification for a group of compounds that contain a quinolizine ring in their structure. A quinolizine ring is a polycyclic aromatic hydrocarbon with eight pi electrons and consists of two benzene rings fused to a piperidine ring.

Quinolizines have been studied for their potential medicinal properties, including anti-malarial, anti-cancer, and anti-microbial activities. However, there are no currently approved drugs that contain quinolizine as the primary active ingredient. Therefore, it is not possible to provide a medical definition of 'Quinolizines.'

Antipruritics are a class of medications or substances that are used to relieve or prevent itching (pruritus). They work by reducing the sensation of itchiness and can be applied topically to the skin, taken orally, or administered intravenously. Some common antipruritics include diphenhydramine, hydroxyzine, and corticosteroids.

Cyclizine is an antihistamine medication that is primarily used to treat and prevent motion sickness and vertigo. It works by blocking the action of histamine, a substance in the body that helps to transmit signals in the brain that can cause symptoms such as dizziness, nausea, and vomiting.

Cyclizine may also be used to treat allergic reactions, including hay fever and hives, as well as to help relieve pain and reduce tension in muscles. It is available in various forms, including tablets, capsules, and liquid solutions, and is typically taken by mouth.

Like all medications, cyclizine can have side effects, which may include drowsiness, dry mouth, blurred vision, and constipation. It is important to follow the dosage instructions provided by a healthcare professional and to report any unusual or severe symptoms to a doctor.

Hyperemesis Gravidarum is a severe form of nausea and vomiting in pregnancy that is more extreme than the typical morning sickness. It's characterized by persistent vomiting, dehydration, weight loss, and electrolyte imbalance. If left untreated, it can lead to serious complications for both the mother and the baby. The exact cause is not known, but it may be related to high levels of hormones or other substances in the pregnant woman's body. Treatment often involves hospitalization for rehydration, medication to control vomiting, and nutritional support.

Intravenous injections are a type of medical procedure where medication or fluids are administered directly into a vein using a needle and syringe. This route of administration is also known as an IV injection. The solution injected enters the patient's bloodstream immediately, allowing for rapid absorption and onset of action. Intravenous injections are commonly used to provide quick relief from symptoms, deliver medications that are not easily absorbed by other routes, or administer fluids and electrolytes in cases of dehydration or severe illness. It is important that intravenous injections are performed using aseptic technique to minimize the risk of infection.

Neurokinin-1 (NK-1) receptor antagonists are a class of drugs that block the action of substance P, a neuropeptide involved in pain transmission and inflammation. These drugs work by binding to NK-1 receptors found on nerve cells, preventing substance P from activating them and transmitting pain signals. NK-1 receptor antagonists have been studied for their potential use in treating various conditions associated with pain and inflammation, such as migraine headaches, depression, and irritable bowel syndrome. Some examples of NK-1 receptor antagonists include aprepitant, fosaprepitant, and rolapitant.

Cisplatin is a chemotherapeutic agent used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. It is an inorganic platinum compound that contains a central platinum atom surrounded by two chloride atoms and two ammonia molecules in a cis configuration.

Cisplatin works by forming crosslinks between DNA strands, which disrupts the structure of DNA and prevents cancer cells from replicating. This ultimately leads to cell death and slows down or stops the growth of tumors. However, cisplatin can also cause damage to normal cells, leading to side effects such as nausea, vomiting, hearing loss, and kidney damage. Therefore, it is essential to monitor patients closely during treatment and manage any adverse effects promptly.

Oral administration is a route of giving medications or other substances by mouth. This can be in the form of tablets, capsules, liquids, pastes, or other forms that can be swallowed. Once ingested, the substance is absorbed through the gastrointestinal tract and enters the bloodstream to reach its intended target site in the body. Oral administration is a common and convenient route of medication delivery, but it may not be appropriate for all substances or in certain situations, such as when rapid onset of action is required or when the patient has difficulty swallowing.

Gynecologic surgical procedures refer to the operations that are performed on the female reproductive system and related organs. These surgeries can be either minimally invasive or open procedures, depending on the condition and the patient's health status.

The indications for gynecologic surgical procedures may include but are not limited to:

1. Diagnosis and treatment of various benign and malignant conditions such as uterine fibroids, ovarian cysts, endometriosis, and cancers of the reproductive organs.
2. Management of abnormal uterine bleeding, pelvic pain, and infertility.
3. Treatment of ectopic pregnancies and miscarriages.
4. Pelvic organ prolapse repair.
5. Sterilization procedures such as tubal ligation.
6. Investigation and treatment of suspicious lesions or abnormal Pap smears.

Some common gynecologic surgical procedures include hysterectomy (removal of the uterus), oophorectomy (removal of the ovary), salpingectomy (removal of the fallopian tube), cystectomy (removal of a cyst), myomectomy (removal of fibroids while preserving the uterus), and endometrial ablation (destruction of the lining of the uterus).

Minimally invasive surgical techniques such as laparoscopy and hysteroscopy have gained popularity in recent years due to their advantages over traditional open surgeries, including smaller incisions, less postoperative pain, quicker recovery times, and reduced risk of complications.

Combination drug therapy is a treatment approach that involves the use of multiple medications with different mechanisms of action to achieve better therapeutic outcomes. This approach is often used in the management of complex medical conditions such as cancer, HIV/AIDS, and cardiovascular diseases. The goal of combination drug therapy is to improve efficacy, reduce the risk of drug resistance, decrease the likelihood of adverse effects, and enhance the overall quality of life for patients.

In combining drugs, healthcare providers aim to target various pathways involved in the disease process, which may help to:

1. Increase the effectiveness of treatment by attacking the disease from multiple angles.
2. Decrease the dosage of individual medications, reducing the risk and severity of side effects.
3. Slow down or prevent the development of drug resistance, a common problem in chronic diseases like HIV/AIDS and cancer.
4. Improve patient compliance by simplifying dosing schedules and reducing pill burden.

Examples of combination drug therapy include:

1. Antiretroviral therapy (ART) for HIV treatment, which typically involves three or more drugs from different classes to suppress viral replication and prevent the development of drug resistance.
2. Chemotherapy regimens for cancer treatment, where multiple cytotoxic agents are used to target various stages of the cell cycle and reduce the likelihood of tumor cells developing resistance.
3. Cardiovascular disease management, which may involve combining medications such as angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, diuretics, and statins to control blood pressure, heart rate, fluid balance, and cholesterol levels.
4. Treatment of tuberculosis, which often involves a combination of several antibiotics to target different aspects of the bacterial life cycle and prevent the development of drug-resistant strains.

When prescribing combination drug therapy, healthcare providers must carefully consider factors such as potential drug interactions, dosing schedules, adverse effects, and contraindications to ensure safe and effective treatment. Regular monitoring of patients is essential to assess treatment response, manage side effects, and adjust the treatment plan as needed.

Ambulatory surgical procedures, also known as outpatient or same-day surgery, refer to medical operations that do not require an overnight hospital stay. These procedures are typically performed in a specialized ambulatory surgery center (ASC) or in a hospital-based outpatient department. Patients undergoing ambulatory surgical procedures receive anesthesia, undergo the operation, and recover enough to be discharged home on the same day of the procedure.

Examples of common ambulatory surgical procedures include:

1. Arthroscopy (joint scope examination and repair)
2. Cataract surgery
3. Colonoscopy and upper endoscopy
4. Dental surgery, such as wisdom tooth extraction
5. Gallbladder removal (cholecystectomy)
6. Hernia repair
7. Hysteroscopy (examination of the uterus)
8. Minor skin procedures, like biopsies and lesion removals
9. Orthopedic procedures, such as carpal tunnel release or joint injections
10. Pain management procedures, including epidural steroid injections and nerve blocks
11. Podiatric (foot and ankle) surgery
12. Tonsillectomy and adenoidectomy

Advancements in medical technology, minimally invasive surgical techniques, and improved anesthesia methods have contributed to the growth of ambulatory surgical procedures, offering patients a more convenient and cost-effective alternative to traditional inpatient surgeries.

Strabismus is a condition of the ocular muscles where the eyes are not aligned properly and point in different directions. One eye may turn inward, outward, upward, or downward while the other one remains fixed and aligns normally. This misalignment can occur occasionally or constantly. Strabismus is also commonly referred to as crossed eyes or walleye. The condition can lead to visual impairments such as amblyopia (lazy eye) and depth perception problems if not treated promptly and effectively, usually through surgery, glasses, or vision therapy.

General anesthesia is a state of controlled unconsciousness, induced by administering various medications, that eliminates awareness, movement, and pain sensation during medical procedures. It involves the use of a combination of intravenous and inhaled drugs to produce a reversible loss of consciousness, allowing patients to undergo surgical or diagnostic interventions safely and comfortably. The depth and duration of anesthesia are carefully monitored and adjusted throughout the procedure by an anesthesiologist or certified registered nurse anesthetist (CRNA) to ensure patient safety and optimize recovery. General anesthesia is typically used for more extensive surgical procedures, such as open-heart surgery, major orthopedic surgeries, and neurosurgery.

Preanesthetic medication, also known as premedication, refers to the administration of medications before anesthesia to help prepare the patient for the upcoming procedure. These medications can serve various purposes, such as:

1. Anxiolysis: Reducing anxiety and promoting relaxation in patients before surgery.
2. Amnesia: Causing temporary memory loss to help patients forget the events leading up to the surgery.
3. Analgesia: Providing pain relief to minimize discomfort during and after the procedure.
4. Antisialagogue: Decreasing saliva production to reduce the risk of aspiration during intubation.
5. Bronchodilation: Relaxing bronchial smooth muscles, which can help improve respiratory function in patients with obstructive lung diseases.
6. Antiemetic: Preventing or reducing the likelihood of postoperative nausea and vomiting.
7. Sedation: Inducing a state of calmness and drowsiness to facilitate a smooth induction of anesthesia.

Common preanesthetic medications include benzodiazepines (e.g., midazolam), opioids (e.g., fentanyl), anticholinergics (e.g., glycopyrrolate), and H1-antihistamines (e.g., diphenhydramine). The choice of preanesthetic medication depends on the patient's medical history, comorbidities, and the type of anesthesia to be administered.

Tetragastrin is not a medical condition but a synthetic peptide hormone that is used in medical research and diagnostic tests. It is composed of four amino acids (glutamic acid, proline, tryptophan, and methionine) and is similar to the natural hormone gastrin, which is produced by the stomach and helps regulate digestion.

Tetragastrin is used in medical research to study the function of the stomach and intestines, and it is also used in diagnostic tests to stimulate the release of gastric acid from the stomach. This can help diagnose conditions such as pernicious anemia, a condition in which the body cannot absorb vitamin B12 due to a lack of intrinsic factor, a protein produced by the stomach.

In summary, Tetragastrin is a synthetic hormone that mimics the function of natural gastrin and is used for research and diagnostic purposes related to the digestive system.

A tonsillectomy is a surgical procedure in which the tonsils, two masses of lymphoid tissue located on both sides of the back of the throat, are removed. This procedure is typically performed to treat recurrent or severe cases of tonsillitis (inflammation of the tonsils), sleep-disordered breathing such as obstructive sleep apnea, and other conditions where the tonsils are causing problems or complications. The surgery can be done under general anesthesia, and there are various methods for removing the tonsils, including traditional scalpel excision, electrocautery, and laser surgery. After a tonsillectomy, patients may experience pain, swelling, and difficulty swallowing, but these symptoms typically improve within 1-2 weeks post-surgery.

No data available that match "doses ondansetron"


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MKO MELT DOSE PACK- midazolam - ketamine hcl - ondansetron troche. Out of scope - Out of scope for RxNorm and will not receive ... MKO MELT DOSE PACK- midazolam - ketamine hcl - ondansetron troche. To receive this label RSS feed. Copy the URL below and paste ... MKO MELT DOSE PACK- midazolam - ketamine hcl - ondansetron troche. If this SPL contains inactivated NDCs listed by the FDA ... MKO MELT DOSE PACK- midazolam - ketamine hcl - ondansetron troche. Number of versions: 1. ...
... ondansetron), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, ... MISSED DOSE: Try to take each dose at the scheduled time. If you miss a dose, take it as soon as you remember unless it is near ... In that case, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up. STORAGE: Store ... Alternatively, 4-8 mg intermittent short-term IV dosing used in adults; single dose of 4 mg single dose used in pregnancy ...
... repeated vs single dose ondansetron administration in preventing pruritus after intrathecal morphine ... Dimitriou, V.; Voyagis, G. S. 1999: Opioid-induced pruritus: repeated vs single dose ondansetron administration in preventing ... Opioid-induced pruritus: repeated vs single dose ondansetron administration in preventing pruritus after intrathecal morphine. ... Ondansetron does not prevent pruritus induced by low-dose intrathecal fentanyl Acta Anaesthesiologica Scandinavica 47(10): 1292 ...
Ondansetron: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and ... The first dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of ... Before taking ondansetron,. *tell your doctor and pharmacist if you are allergic to ondansetron, alosetron (Lotronex), ...
The DOSE-AGE trial will provide evidence on the effectiveness of multiple doses of oral ondansetron, taken as needed, following ... Thus, the Multi-Dose Oral Ondansetron for Pediatric Gastroenteritis (DOSE-AGE) trial will evaluate the effectiveness of ... there is little evidence of additional benefit from prescribing ondansetron beyond the initial ED dose. Moreover, repeat dosing ... many physicians across North America provide multiple doses of ondansetron to be taken following ED disposition. ...
Ibuprofen dosing for children Taking ibuprofen can help children feel better when they have colds or minor injuries. As with ... Ondansetron Injection Ondansetron injection is used to prevent nausea and vomiting caused by cancer chemotherapy and surgery. ... Ondansetron Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. ... Results 1 - 10 of 1,247 for IBUPROFEN OR MIFEPRISTONE OR MISOPROSTOL OR ONDANSETRON ...
... as it is written in UptoDate.com that the Max per dose is 16mg is that means that maximum per day will be 48 mg ?? ... Can I ask about the maximum daily dose of Ondansetron dosed on 0.15mg/kg/dose on HEC, ... Ondansetron 16mg is not longer recommended as a single dose nor is the 32mg dose daily dose. As mentioned QTc prolongation is ... Can I ask about the maximum daily dose of Ondansetron dosed on 0.15mg/kg/dose on HEC, as it is written in UptoDate.com that the ...
Ondansetron oral tablets are prescribed for nausea and vomiting in certain situations. Learn about side effects, warnings, ... Dose. • 8 mg per dose. How often. • one dose 30 minutes before a chemotherapy session followed by a second dose 8 hours later, ... Dose. 8 mg per dose. How often. • for radiation therapy that treats the whole body: one dose 1 to 2 hours before each session. ... How long does it take ondansetron to work?. Ondansetron typically starts working within 30 minutes after you take your dose. ...
Includes common brand names, drug descriptions, warnings, side effects and dosing information. ... Detailed Rheumatrex Dose Pack dosage information Precautions while using Rheumatrex Dose Pack. It is very important that your ... Missed Dose. This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your ... Dosing. The dose of this medicine will be different for different patients. Follow your doctors orders or the directions on ...
The first trial compared oral doses of ondansetron 24 mg as a single dose, 8 mg every 8 hours for 2 doses, and 32 mg as a ... The initial dose of ondansetron injection ranged from 0.04 to 0.87 mg per kg (total dose of 2.16 mg to 12 mg) followed by the ... ondansetron 4 MG per 5 ML Oral Solution. SY. 4. 312085. ondansetron (as ondansetron HCl dihydrate) 4 MG per 5 ML Oral Solution ... The first 8-mg dose of ondansetron was administered 30 minutes before the start of chemotherapy, with a subsequent dose 8 hours ...
The goal of this study was to determine whether CYP2D6 metabolizer status within the ondansetron-treated pediatric ... Prescribing prevalence of medications with potential genotype‐guided dosing in pediatric patients. JAMA Netw Open. 2020;3(12): ... Pediatric CYP2D6 metabolizer status and post-tonsillectomy nausea and vomiting after ondansetron Katherine Black 1 , B Randall ... Pediatric CYP2D6 metabolizer status and post-tonsillectomy nausea and vomiting after ondansetron Katherine Black et al. Clin ...
Muth ER, Elkins AN (July 2007). "High dose ondansetron for reducing motion sickness in highly susceptible subjects". Aviat ... Ondansetron was approved by the U.S. Food and Drug Administration in 1991, and has since become available in several other ... Ondansetron is a racemate but the stereochemistry of the asymmetric carbon atom is not an important factor in the 5-HT3 ... As of 2008, ondansetron and granisetron are the only 5-HT3 antagonists available as a generic drug in the United States. ...
A computer model demonstrated that the amounts in milk are much less than this dose. No special precautions are required. ... Use of ondansetron in nursing mothers beyond the immediate postpartum setting has not been studied well, but the drug is ... usually in doses of 4 to 8 mg intravenously.[1-4] Use during and after cesarean section appears to not affect the onset of ... breastfeeding.[1,5] No adverse infant effects have been reported in this setting or among women who received ondansetron ...
High dose ondansetron for reducing motion sickness in highly susceptible subjects. Aviat Space Environ Med. 2007 Jul. 78(7):686 ... Simmons RG, Phillips JB, Lojewski RA, Wang Z, Boyd JL, Putcha L. The efficacy of low-dose intranasal scopolamine for motion ... Bar R, Gil A, Tal D. Safety of double-dose transdermal scopolamine. Pharmacotherapy. 2009 Sep. 29(9):1082-8. [QxMD MEDLINE Link ... Hershkovitz D, Asna N, Shupak A, Kaminski G, Bar R, Tal D. Ondansetron for the prevention of seasickness in susceptible sailors ...
... acromegaly dosing for Signifor, Signifor LAR (pasireotide), frequency-based adverse effects, comprehensive interactions, ... ondansetron. Monitor Closely (1)ondansetron and pasireotide both increase QTc interval. Modify Therapy/Monitor Closely. ... MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose ... Missed dose. *If a dose is missed and the patient returns prior to the next scheduled dose, dose may be given ≤14 days prior to ...
Safety of ondansetron loading doses in children with cancer.. Hasler SB; Hirt A; Ridolfi Luethy A; Leibundgut KK; Ammann RA. ... The use of ondansetron in the treatment of nausea and vomiting associated with acetaminophen poisoning.. Clark RF; Chen R; ... Ondansetron, an antagonist of 5-HT3 receptors, in the treatment of antineoplastic drug-induced nausea and vomiting in children. ... Ondansetron and metoclopramide as second-line antiemetics in women with nausea and vomiting in pregnancy: the EMPOWER pilot ...
erythromycin dose for strep. Español. Levitra Farmacie ondansetron (zofran) uses. Cialis is indicated for the treatment of ... Click aquí . Pharmacie Monge Levitra ondansetron (zofran) uses. lexapro anxiety wiki. ThePharmacyOne-24 ondansetron (zofran) ... com We check safety credentials of online pharmacies to protect your health ondansetron (zofran) uses ondansetron (zofran) uses ... à Bruxelles en ondansetron (zofran) uses. Best quality ondansetron (zofran) uses. Farmacie Online Sicure Viagra. Gutscheine, ...
A single dose of ondansetron is safe and effective in children who have acute gastroenteritis and are unable to tolerate oral ... Typically, only a single dose is used because repeated doses can cause persistent diarrhea. Other common adverse effects ... Ondansetron: 0.15 mg/kg (maximum 8 mg) IV every 8 hours or, if the oral form is used, for children 2 to 4 years, 2 mg every 8 ... Ondansetron is a selective serotonin (5-HT3) receptor blocker that inhibits the initiation of the vomiting reflex in the ...
Ondansetron Injection prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, ... 6 months-18yrs: 0.15mg/kg (max 16mg/dose) IV for 3 doses every 4hrs beginning 30 mins before chemotherapy. Post-op (do not ... Ondansetron Injection Boxed Warnings. Not Applicable. Ondansetron Injection Warnings/Precautions. Warnings/Precautions ,4 ... Ondansetron Injection Pharmacokinetics. See Literature. Ondansetron Injection Interactions. Interactions See Contraindications ...
Randomized open-label phase II trial of 5-day aprepitant plus ondansetron compared to ondansetron alone in the prevention of ... Serrone L, Zeuli M, Gamucci T, Nardi M, Cognetti F. A phase II study of dose-intense ifosfamide plus epirubicin with ... Comparison of L-758,298, a prodrug for the selective neurokinin-1 antagonist, L-754,030, with ondansetron for the prevention of ... Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas. Am ...
... in a dose-dependent manner; 2) the doses that demonstrate target engagement are safe and tolerable; and 3) change-in-function ... ondansetron, L-DOPA, ezogabine, tetrahydrocannabinol (THC), and levetiracetam. However, some projects proposed the testing of ... For example, if an investigator finds a dose-related effect of a drug on the performance of mice on a non-specific behavioral ... This pharmacologic-based testing approach focused on associating dose with drug exposure and CNS response (PD effect) in order ...
About 36.7% patients had episodes of nausea on day four of chemotherapy in ondansetron group and it was only 3.3% in ... Granisetron group required additional doses only 3.3% cases and ondanseton group 30% cases on the second day (p,0.05). ... Effect of ondansetron and granisetron were evaluated in sixty (60) children (age 4-11 years) irrespective of sex, diagnosed ... Maximum episodes of vomiting were found on the second day in ondansetron group 33.3% and in granisetron group 3.3% (p=0.003). ...
Rock, E.M.; Parker, L.A. Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model ... 1 dose, also showed anxiolytic-like effects under conditions of high stress [41]. The brain and plasma pharmacokinetic profile ... at a 10 mg/mL dose level, were analyzed using a Shimadzu NEXERA UHPLC system (Shimadzu, Tokyo, Japan) equipped with a Luna® ... at a 10 mg/mL dose level, were analyzed using a Shimadzu NEXERA UHPLC system (Shimadzu, Tokyo, Japan) equipped with a Luna® ...
Ondansetron is used alone or with other medications to prevent nausea and vomiting. Learn about side effects, drug interactions ... Alternatively, 4-8 mg intermittent short-term intravenous dosing is used in adults; a single dose of 4 mg single dose used in ... This medication contains ondansetron. Do not take Zofran, Zofran ODT, or Zuplenz if you are allergic to ondansetron or any ... Single high-dose fraction therapy to the abdomen: 8 mg orally 1-2 hours before radiation therapy; administer subsequent doses ...
The agency is warning that the drug administered at this dose can impact a patients QT interval, a measure of a hearts ... In addition to its brand name form, Zofran is also known as ondansetron hydrochloride dihydrate or ondansetron in generic form. ... Health Canadas warning does not include any dosing instruction changes for lower doses of Zofran, including those who are ... Zofran at this dose can prolong a patients QT interval. This condition can lead to dizziness and cause an irregular heartbeat ...
Ondansetron) - Drug Info, User Reviews, Side Effects, Research, Clinical Trials ... The purpose of this study was to assess the single dose bioequivalence of Ondansetron OSF 8mg (Manufactured by MonoSol Rx, USA ... This study, called a thorough QT study, will characterize the effects of a single intravenous (IV) dose of ondansetron on ... I had a decrease in the nausea symptoms after the first dose, and had total relief after about 3 doses. i did experience a mile ...
  • Each oval-shaped, yellow, coated tablet, debossed with 'OD' on one side and '8' on the other side, contains 8 mg of ondansetron (as ondansetron hydrochloride dihydrate). (medbroadcast.com)
  • The active ingredient in ondansetron tablets USP is ondansetron hydrochloride (HCl) USP as the dihydrate, the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT 3 receptor type. (nih.gov)
  • Ondansetron HCl USP dihydrate is a white to off-white powder that is soluble in water and normal saline. (nih.gov)
  • Each 4-mg ondansetron tablet USP for oral administration contains ondansetron HCl USP dihydrate equivalent to 4 mg of ondansetron. (nih.gov)
  • Ondansetron injection is used to prevent nausea and vomiting caused by cancer chemotherapy and surgery. (medlineplus.gov)
  • When ondansetron is used to prevent nausea and vomiting caused by chemotherapy, it is usually given 30 minutes before the start of chemotherapy. (medlineplus.gov)
  • Clinical trials suggest that it is more effective than other 5-HT3 antagonists in preventing delayed CINV (nausea and vomiting that occur more than 24 hours after the first dose of chemotherapy). (wikipedia.org)
  • A single dose of 8mg by slow intravenous injection (in not less than 30 seconds) or intramuscular injection immediately before chemotherapy 2 mg sciroppo ogni 12 ore. (seagullindia.com)
  • The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment. (seagullindia.com)
  • The total dose over 24 hours (given as divided doses) must not exceed adult dose of 32 mg If you are undergoing chemotherapy, Zofran ODT is typically taken 30 minutes prior to the start of treatment. (seagullindia.com)
  • 15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose. (seagullindia.com)
  • Zofran should be administered immediately before chemotherapy as a single intravenous dose of 5 mg/m 2. (seagullindia.com)
  • The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment dose of 16 mg IV infused over 15 minutes may be used. (seagullindia.com)
  • ZOFRAN® Injection is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin [see Clinical Studies ]. (globalrph.com)
  • The first dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy. (globalrph.com)
  • The first dose is to be administered 30 minutes before the start of moderately to highly emetogenic chemotherapy. (globalrph.com)
  • Highly emetogenic chemotherapy: 24mg once 30 mins before start of single-day chemotherapy (multi-day, single-dose not studied). (empr.com)
  • Moderately emetogenic chemotherapy: 8mg every 8hrs for 2 doses beginning 30 mins before chemotherapy, then 8mg every 12hrs for 1-2 days after chemotherapy completed. (empr.com)
  • The recommended adult dose of ondansetron for nausea and vomiting caused by chemotherapy is based on severity of the symptoms and ranges from 8 mg to 24 mg daily given in divided doses. (medbroadcast.com)
  • Ondansetron should be taken ½ to 1 hour before chemotherapy treatment. (medbroadcast.com)
  • Ondansetron works by selectively blocking serotonin (5-HT3) receptors, reducing the effect of increased serotonin due to chemotherapy. (hdkino.org)
  • The dose of Zofran depends on the type of chemotherapy -high risk for nausea and vomiting or medium risk. (modafinia.com)
  • High-risk chemotherapy: The dose of Zofran for high-risk chemotherapy is Zofran 24 mg (taken as three 8 mg tablets) 30 minutes before chemotherapy. (modafinia.com)
  • Medium-risk chemotherapy: The dose of Zofran for medium-risk chemotherapy is Zofran 8 mg twice daily. (modafinia.com)
  • The first dose should be taken 30 minutes before chemotherapy, and the second dose should be taken eight hours after the first dose. (modafinia.com)
  • Ondansetron Medis Melt is indicated for the management of nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy. (pillintrip.com)
  • Ondansetron hcl 4mg tablet is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. (canadadrugs.co)
  • Ondansetron may be taken up to 3 times a day for 1 to 2 days after your chemotherapy or radiation treatment is finished. (canadadrugs.co)
  • Conclusion: It was concluded that granisetron is more effective than ondansetron and placebo in controlling postoperative nausea & vomiting after laparoscopic gynecological surgery. (ispub.com)
  • already benefits patients in the UK, France, Italy and Spain by offering an alternative form of ondansetron. (norgine.com)
  • tell your doctor and pharmacist if you are allergic to ondansetron, alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), palonosetron (Aloxi), or any other medications: or any of the ingredients in ondansetron injection. (medlineplus.gov)
  • As of 2008, ondansetron and granisetron are the only 5-HT3 antagonists available as a generic drug in the United States. (wikipedia.org)
  • Introduction: The aim of the study was to compare the antiemetic effects of intravenous ondansetron 80 mcg/kg and granisetron 40 mcg/kg in a double blind placebo controlled manner for prevention of postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgeries. (ispub.com)
  • Group A (n=30) received 40mcg/kg granisetron intravenously, group B (n=30) received 80mcg/kg ondansetron intravenously and group C (n=30) received 5 ml of normal saline by the same route 2 minutes before induction of general anaesthesia. (ispub.com)
  • Results: The incidence of nausea and vomiting over a period of 24 hour were found in 20% of patients who had received granisetron, 45% of patients who had received ondansetron and 77.5% of patients who had received placebo. (ispub.com)
  • The newer antiemetics used for the prevention and treatment of PONV are 5HT 3 receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron) are devoid of these side effects. (ispub.com)
  • The use of these 5-HT 3 receptor antagonists have been shown to improve patients' satisfaction, decrease recovery and discharge times and reduced an unanticipated hospital admission especially when they are used prophylactically 25 26 .This prospective, randomized, double blind placebo controlled study was undertaken to compare the efficacy of granisetron and ondansetron in prevention PONV in patients undergoing gynecological laparoscopic surgeries. (ispub.com)
  • These patients received 40 μg/kg granisetron in group A, Ondansetron (80 μg/kg) in group B and 0.9% saline in group C two minutes prior to induction of anesthesia. (ispub.com)
  • IV: 4 to 8 mg every 8 hours Use Zofran (ondansetron injection) as ordered by your doctor. (seagullindia.com)
  • 1) Use Zofran (ondansetron injection) as ordered by your doctor. (seagullindia.com)
  • The active ingredient of ZOFRAN Injection is ondansetron hydrochloride, a selective blocking agent of the serotonin 5-HT3 receptor type. (globalrph.com)
  • The PBAC recommended listing on a cost minimisation basis with adrenaline I.M. injection single dose syringe auto-injector (EpiPen). (pbs.gov.au)
  • Alternatively, a dose of 4 mg may be given by intravenous (into a vein) injection at the time of surgery. (medbroadcast.com)
  • After surgery, a single dose of 4 mg of ondansetron may be given by intravenous injection to treat nausea or vomiting. (medbroadcast.com)
  • Each 4-mg ondansetron orally disintegrating tablet USP for oral administration contains 4 mg ondansetron base. (nih.gov)
  • Each ondansetron orally disintegrating tablet USP also contains the inactive ingredients aspartame, colloidal silicon dioxide, crospovidone, magnesium stearate, mannitol, sodium stearyl fumarate and strawberry flavor. (nih.gov)
  • If you are taking the rapidly disintegrating tablet, remove the tablet from the package just before you take your dose. (seagullindia.com)
  • Ondansetron hcl 4mg tablet is dissolved on top of the tongue. (canadadrugs.co)
  • Dry your hands before using Ondansetron HCL 4mg tablet. (canadadrugs.co)
  • Ondansetron HCL 4mg tablet may come in a bottle or a blister pack. (canadadrugs.co)
  • Ondansetron hcl 4mg tablet may be taken with or without food. (canadadrugs.co)
  • Ondansetron comes as a solution (liquid) to be injected intravenously (into a vein) or intramuscularly (into a muscle) by a health care provider in a hospital or clinic. (medlineplus.gov)
  • The study group (n = 184) received 4 mg of ondansetron intravenously 30 minutes prior to completion of the surgery. (seagullindia.com)
  • Ondansetron is in a class of medications called serotonin 5-HT 3 receptor antagonists. (medlineplus.gov)
  • Ondansetron works by blocking a subtype of serotonin receptors associated with nausea (5-HT3). (pharmacytimes.com)
  • Ondansetron works by blocking one of the body's natural substances (serotonin) that causes vomiting. (canadadrugs.co)
  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. (cdc.gov)
  • Your doctor will probably tell you not to use ondansetron if you are receiving this medication. (medlineplus.gov)
  • A recent trial indicates that the antinausea medication ondansetron may have some utility in treating the symptoms of diarrhea-associated irritable bowel syndrome. (pharmacytimes.com)
  • I got myself a GP appointment and went in with a list of medication, including a new one that I hadn't been offered first time round (ondansetron, if you're interested). (breastfeedingnetwork.org.uk)
  • Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. (medbroadcast.com)
  • If your doctor has recommended a dose different from the one given here, do not change the way that you are taking the medication without consulting your doctor. (medbroadcast.com)
  • A side effect is an unwanted response to a medication when it is taken in normal doses. (medbroadcast.com)
  • suggest travelers take a trial dose of medication at home before departure to find what works best for them. (cdc.gov)
  • Ondansetron is an anti-nausea medication and promethazine is a phenothiazine. (hdkino.org)
  • The medications with the highest potential for actionability were analgesics, the antiemetic ondansetron, and antidepressants. (cdc.gov)
  • 500mg.org provides you with the chance to buy inexpensive Ondansetron 4, 8 mg online and also find out more about Ondansetron side effects, dosage information and drug interactions. (llclinic.com)
  • Your doctor or pharmacist will be able to tell you what to do when taking ONDANSETRON TABS PFIZER with other medicines. (mydr.com.au)
  • If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. (medbroadcast.com)
  • When people purchase Ondansetron online with on-line sources that are trusted, however, access to a licensed pharmacist is just a phone call away. (llclinic.com)
  • Be careful and be sure to specify the information on the section in the instructions to the drug Ondansetron Medis directly from the package or from the pharmacist at the pharmacy. (pillintrip.com)
  • Before taking ondansetron, tell your doctor or pharmacist if you are allergic to it. (canadadrugs.co)
  • The 8-mg dose is taken again 8 hours after the first dose. (mayoclinic.org)
  • The second and third 4-mg films are taken 4 and 8 hours after the first dose. (mayoclinic.org)
  • Additional doses may be given 4 hours after the first dose of ondansetron and 8 hours after the first dose of ondansetron, if needed. (medlineplus.gov)
  • Subsequent doses (0.15 mg/kg up to a maximum of 16 mg per dose) are administered 4 and 8 hours after the first dose of ZOFRAN. (globalrph.com)
  • It is important to note that, unlike the 5-HT3 antagonist Lotronex (alosetron), ondansetron does not have an FDA-approved indication for IBS. (pharmacytimes.com)
  • This small study is inadequate to prove the safety of ondansetron in patients with IBS, but researchers noted that, unlike alosetron, ondansetron has been used for over 25 years without a single report of ischemic colitis. (pharmacytimes.com)
  • Efficacy of contraceptives may be reduced during administration of and for 28 days following the last dose of EMEND. (nih.gov)
  • Off-label use of ondansetron may offer some patients with IBS-D a lower-cost option with evidence of efficacy in symptom reduction at doses as low as 4 mg daily. (pharmacytimes.com)
  • Ondansetron for Irritable Bowel Syndrome With Diarrhea This placebo-controlled RCT demonstrated the efficacy of titrated ondansetron for managing key symptoms of IBS-D. (medscape.com)
  • Effects of MD-7246 on Irritable Bowel Syndrome With Diarrhea This study evaluated the efficacy, safety and dose-response of MD-7246, a delayed-release formulation of linaclotide, in patients with IBS-D. (medscape.com)
  • Ondansetron is a selective 5-HT 3 receptor antagonist. (nih.gov)
  • Ondansetron is a selective 5-HT3 receptor antagonist. (empr.com)
  • International researchers are delving further into the manufacturing of patient-specific medications, outlining their findings in 'Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron. (3dprint.com)
  • A single dose greater than 16 mg must not be given due to dose dependent increase of QT- prolongation risk (see sections 4. (seagullindia.com)
  • Ondansetron may cause a condition that affects the heart rhythm (QT prolongation). (canadadrugs.co)
  • Adult patients aged less than 75 years: A single dose of intravenous ondansetron given for the prevention of CINV in adults (aged less than 75 years) must not exceed 16mg(infused over at least 15 minutes) 2 mg sciroppo ogni 12 ore. (seagullindia.com)
  • Ondansetron orally disintegrating tablets USP are an orally administered formulation of ondansetron which rapidly disintegrates on the tongue and does not require water to aid dissolution or swallowing. (nih.gov)
  • Comments: Multi-day, single-dose administration of 24 mg orally for HEC has not been studied Common side effects of taking Zofran ODT for the prevention of nausea and vomiting caused by radiation are: Headache. (seagullindia.com)
  • Corresponding doses of ZOFRAN tablets, ZOFRAN ODT® orally disintegrating tablets and ZOFRAN oral. (seagullindia.com)
  • The dose of this medicine will be different for different patients. (mayoclinic.org)
  • Ondansetron is also sometimes given after surgery to patients who are experiencing nausea and vomiting and who did not receive ondansetron before surgery. (medlineplus.gov)
  • EMEND for oral suspension in pediatric patients 6 months to less than 12 years of age or pediatric and adult patients unable to swallow capsules: see dosing recommendations in Table 3 in the Full Prescribing Information. (nih.gov)
  • For pediatric patients aged 6 months through 18 years, the intravenous dosage of ZOFRAN is three 0.15-mg/kg doses up to a maximum of 16 mg per dose [see Clinical Studies , CLINICAL PHARMACOLOGY ]. (globalrph.com)
  • Patients then received 5 weeks of treatment with ondansetron or placebo and recorded bowel symptoms in a diary. (pharmacytimes.com)
  • Over the first 3 weeks, patients were instructed to increase the dose slowly to a maximum total daily dose of 24 mg (8 mg 3 times daily). (pharmacytimes.com)
  • Almost two-thirds of patients (65%) treated with ondansetron reported adequate relief of IBS symptoms compared with 14% of patients receiving placebo. (pharmacytimes.com)
  • This adverse event occurred in 9% of patients taking ondansetron. (pharmacytimes.com)
  • Constipation was generally reversible with a dose reduction, although 2% of patients stopped taking ondansetron due to the adverse event. (pharmacytimes.com)
  • Dronabinol treatment is safe and well-tolerated in OSA patients at doses of 2.5-10 mg daily and significantly reduces AHI in the short-term. (frontiersin.org)
  • This could be due to lack of effect of CBD on Crohn's disease, but could also be due to the small dose of CBD, the small number of patients in the study, or the lack of the necessary synergism with other cannabinoids. (springer.com)
  • and radiotherapy in patients receiving total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen. (empr.com)
  • Therapy should not be abruptly discontinued in patients receiving high doses for prolonged periods. (lybrate.com)
  • It is occasionally the most vast adhe to all relative fibres, likewise exemplified in the material of native entire patients, other doses, notic, and secretion of the impressions. (clayalliance.org)
  • Prevention of nausea and vomiting associated with radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen. (pillintrip.com)
  • In patients where nausea and/or vomiting must be avoided postoperatively, Ondansetron Medis tablets are recommended even where the incidence of postoperative nausea and/or vomiting is low. (pillintrip.com)
  • In patients with severe liver problems, the usual maximum dose is 8 milligrams in 24 hours. (canadadrugs.co)
  • In normal volunteers, single intravenous doses of 0.15 mg/kg of ondansetron had no effect on esophageal motility, gastric motility, lower esophageal sphincter pressure, or small intestinal transit time. (nih.gov)
  • The single intravenous dose must not exceed 8 mg. (seagullindia.com)
  • Although slowing colonic transit time may be therapeutic at low doses, large doses of ondansetron may lead to constipation. (pharmacytimes.com)
  • Side effects of ondansetron and promethazine that are similar include drowsiness and sedation, constipation , and dizziness . (hdkino.org)
  • The recommended adult intravenous dosage of ZOFRAN is three 0.15-mg/kg doses up to a maximum of 16 mg per dose [see CLINICAL PHARMACOLOGY ]. (globalrph.com)
  • If use is unavoidable, closely monitor for adverse reactions and consider dose reduction of BCRP substrate drug (refer BCRP substrate prescribing information). (medscape.com)
  • Check with your doctor as soon as possible if you think you are experiencing any side effects or allergic reactions due to taking Ondansetron Tabs Pfizer, even if the problem is not listed below. (mydr.com.au)
  • Rarely, this product causes potentially severe reactions, mostly if taken at high doses or with some other drugs. (familiprix.com)
  • Your doctor may need to change the doses of your medications or monitor you more carefully for side effects. (medlineplus.gov)
  • Like other medicines, Ondansetron Tabs Pfizer can cause some side effects. (mydr.com.au)
  • This page from Great Ormond Street Hospital (GOSH) explains what ondansetron is, how it is given and some of the possible side effects. (seagullindia.com)
  • Side effects of ondansetron that are different from promethazine include headache , feeling unwell (malaise), fatigue , diarrhea , and abnormal heart rate and rhythm. (hdkino.org)
  • What are the side effects of ondansetron and promethazine? (hdkino.org)
  • Multiday administration of ondansetron has been shown to slow colonic transit in normal volunteers. (nih.gov)
  • Fass environmental information for Zofran munlöslig (ondansetron) from Novartis (downloaded 2023-02-06). (janusinfo.se)
  • The information provided in Therapeutic indications of Ondansetron Medis is based on data of another medicine with exactly the same composition as the Ondansetron Medis . (pillintrip.com)
  • While its mechanism of action has not been fully characterized, ondansetron is not a dopamine-receptor antagonist. (nih.gov)
  • Ondansetron Medis Melt is indicated for the prevention of post-operative nausea and vomiting (PONV). (pillintrip.com)
  • Brand names for ondansetron include Zofran , Zofran ODT , and Zuplenz. (hdkino.org)
  • Therefore, by design, dose-escalation of dronabinol was permitted only if the lower dose was not associated with adverse events. (frontiersin.org)
  • Purchase Ondansetron without a prescription or Generic Zofran from 500mg.org and get superb drug on reduced international prices. (llclinic.com)
  • By comparison, the best on-line sources for prescription drugs like Ondansetron often have extensive drug info right on the website, so consumers can get answers to their own questions quickly and easily when they purchase Ondansetron 4, 8 mg online, and they could easily print out the advice for future reference. (llclinic.com)
  • Norgine B.V. acquires SETOFILM® (ondansetron oral dispersible film) in Europe, Australia and New Zealand From APR Applied Pharma Research S.A. (norgine.com)
  • Oral dosing can commence 12 hours later and may be continued for up to 5 days (Table 1). (seagullindia.com)
  • Use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons. (medbroadcast.com)
  • Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: comparison of split vs single dose. (nottingham.ac.uk)
  • Single high-dose fraction radiotherapy to abdomen: 8mg 1-2hrs before radiotherapy, then 8mg every 8hrs after 1st dose for 1-2 days after radiation completed. (empr.com)
  • A randomized, placebo-controlled trial of ondansetron to treat motion sickness in air ambulance personnel showed subjective improvement, but it was not statistically significant. (wikipedia.org)
  • Investigators at the University of Nottingham and associated hospitals in the United Kingdom found that ondansetron improved stool consistency and several markers of diarrhea-associated irritable bowel syndrome (IBS-D) symptoms compared with placebo. (pharmacytimes.com)
  • The recommended adult dose of ondansetron to treat and prevent nausea and vomiting caused by radiation therapy is 8 mg taken by mouth, 1 to 2 hours before treatment, and then every 8 hours for up to 5 days after treatment. (medbroadcast.com)
  • The recommended adult dose of ondansetron to prevent nausea and vomiting caused by surgery is 16 mg taken by mouth, 1 hour before anesthesia. (medbroadcast.com)
  • Ondansetron is not effective for treating or preventing nausea and vomiting caused by motion. (medbroadcast.com)
  • If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. (mydr.com.au)
  • If you miss a dose, and you do not feel sick, skip the missed dose and continue with your regular schedule. (medbroadcast.com)
  • If you miss for long time and it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. (modafinia.com)
  • Ondansetron was approved by the U.S. Food and Drug Administration in 1991, and has since become available in several other countries, including the UK, Ireland, Australia, Canada, France and Brazil. (wikipedia.org)
  • Ondansetron and promethazine belong to different drug classes. (hdkino.org)
  • Functionality of elicited antibodies was demonstrated by Serum Bactericidal activity Assays and a potential booster dose of this vaccine had a severe allergic reaction to any ingredient of this. (seagullindia.com)
  • Buy generic Zofran online at the finest affordable cost from 500mg.org and get your Ondansetron pills sent at your doorstep in time. (llclinic.com)
  • Ondansetron and promethazine are used to prevent nausea and vomiting . (hdkino.org)
  • To prevent nausea after surgery, take ondansetron HCL 4mg used for nausea 1 hour before the start of surgery. (canadadrugs.co)