Amantadine: An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.Rimantadine: An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.Adamantane: A tricyclo bridged hydrocarbon.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Dyskinesias: Abnormal involuntary movements which primarily affect the extremities, trunk, or jaw that occur as a manifestation of an underlying disease process. Conditions which feature recurrent or persistent episodes of dyskinesia as a primary manifestation of disease may be referred to as dyskinesia syndromes (see MOVEMENT DISORDERS). Dyskinesias are also a relatively common manifestation of BASAL GANGLIA DISEASES.Antiparkinson Agents: Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.Influenza A virus: The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.Viral Matrix Proteins: Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.Dopamine Agents: Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.Coma, Post-Head Injury: Prolonged unconsciousness from which the individual cannot be aroused, associated with traumatic injuries to the BRAIN. This may be defined as unconsciousness persisting for 6 hours or longer. Coma results from injury to both cerebral hemispheres or the RETICULAR FORMATION of the BRAIN STEM. Contributing mechanisms include DIFFUSE AXONAL INJURY and BRAIN EDEMA. (From J Neurotrauma 1997 Oct;14(10):699-713)Influenza, Human: An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.Zanamivir: A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.Memantine: AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent.1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.MPTP Poisoning: A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)Parkinson Disease, Secondary: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.Golf: A game whose object is to sink a ball into each of 9 or 18 successive holes on a golf course using as few strokes as possible.Contract Services: Outside services provided to an institution under a formal financial agreement.Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)Influenza A Virus, H1N1 Subtype: A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.Societies, Pharmaceutical: Societies whose membership is limited to pharmacists.Internship, Nonmedical: Advanced programs of training to meet certain professional requirements in fields other than medicine or dentistry, e.g., pharmacology, nutrition, nursing, etc.Reference Books, Medical: Books in the field of medicine intended primarily for consultation.Pharmacists: Those persons legally qualified by education and training to engage in the practice of pharmacy.Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.Arabinofuranosyluracil: A pyrimidine nucleoside formed in the body by the deamination of CYTARABINE.Herpesvirus 3, Human: The type species of VARICELLOVIRUS causing CHICKENPOX (varicella) and HERPES ZOSTER (shingles) in humans.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Herpes Zoster: An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Chickenpox: A highly contagious infectious disease caused by the varicella-zoster virus (HERPESVIRUS 3, HUMAN). It usually affects children, is spread by direct contact or respiratory route via droplet nuclei, and is characterized by the appearance on the skin and mucous membranes of successive crops of typical pruritic vesicular lesions that are easily broken and become scabbed. Chickenpox is relatively benign in children, but may be complicated by pneumonia and encephalitis in adults. (From Dorland, 27th ed)Ganciclovir: An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.Cytomegalovirus Retinitis: Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in AIDS patients and can cause blindness.Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.AIDS-Related Opportunistic Infections: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
  • CNS effects) may be minimized if daily dosage is given in 2 equally divided doses. (drugs.com)
  • So, medicine for verapamil dose of tramadol maximum dosage for acute pain score vas from prescribing tramadol er. (cleverlearn.com)
  • It is often safest to try reducing the dosage of drugs that could be causing the symptom to see whether the symptom abates before increasing the dose or adding other drugs. (medscape.com)
  • Study of Amantadine for Risperidone Consta or Paliperidone Treated Patients to Decrease Prolactin Elevation Alosetron: Moderate Alosetron, Buy Generic Accutane in USA the usual dosage for the management of fatigue in people with multiple sclerosis is 100 to 200 mg every day, taken in the morning or just after Amantadine Online no Prior Prescription the long-term efficacy of amantadine for the treatment of Huntington's chorea is unknown. (unionsentinel.com)
  • With a product like Amantadine, our syrup form is a much-needed alternative for children over one year of age and for adults who prefer good-tasting liquids to solid oral dosage forms. (news-medical.net)
  • The dose-response curve for d-amphetamine indicated that the 0.5 mg/kg dosage provided for optimal discrimination of SDR, while dosages of 1.0 mg/kg and 2.0 mg/kg proved to be disruptive. (tennessee.edu)
  • Analgesic properties of two aminoadamantanes, amantadine (20 mg/kg) and hemantane (20 mg/kg), which were uncompetitive NMDA receptor antagonists, were assessed in rodent models of pain induced by different pain stimuli (tail-flick test, acetic twitches test in mice and formalin test in rats). (scirp.org)
  • Amantadine is an antiglutamatergic drug with NMDA receptor antagonistic properties. (frontiersin.org)
  • Amantadine and related drugs are also potent antagonists at the N-methyl-D-aspartate (NMDA) receptor. (neurology.org)
  • In this regard, amantadine derivatives, which are potent NMDA antagonists, are protective of neurons in experimental models of excitotoxicity. (neurology.org)
  • The analgesic activity of amantadine administered intraperitoneally was more pronounced in the case of acute thermal pain in mice compared to hemantane, and only amantadine had a significant analgesic effect on the acute early phase of formalin pain in rats induced by the effect of the algogen on the primary sensory afferents. (scirp.org)
  • In order to meet the increase in demand for Amantadine resulting from the flu vaccine shortage, Morton Grove Pharmaceuticals immediately responded to a request by the Food and Drug Administration by making emergency arrangements to obtain raw materials from Europe to increase production of their Amantadine HCl Syrup, USP 50 mg/mL. (news-medical.net)
  • Patients with a history of CHF or peripheral edema should be followed closely as there are patients who developed congestive heart failure while receiving amantadine. (pediatriconcall.com)
  • The dose of amantadine may need careful adjustment in patients with congestive heart failure, peripheral edema, or orthostatic hypotension. (healthyplace.com)
  • all randomized subjects who received ≥ 1 dose of study drug and provided ≥ 1 postbaseline efficacy assessment (121) were included in the Modified Intent-to-Treat (MITT) population (58 placebo, 63 ADS-5102). (clinicaltrials.gov)
  • In this study, we compared the efficacy of triple therapy (interferon alfa, ribavirin, and amantadine) with standard therapy (interferon alfa and ribavirin) in treatment naïve patients with chronic hepatitis C virus (HCV). (bmj.com)
  • The safety and efficacy of use of amantadine in infants less than 1 year old have not been established. (healthyplace.com)
  • This statement discusses the presently available medical-control measures, immunoprophylaxis with vaccines, and prophylaxis or therapy with the antiviral drug, amantadine. (cdc.gov)
  • We will explain the pharmacology of amantadine and the potential side effects of a single dose before we obtain consent. (clinicaltrials.gov)
  • Subjects will be informed that side effects from this drug ingestion are highly unlikely because only a single dose will be administered. (clinicaltrials.gov)
  • However, these are the side effects associated with chronic ingestion of amantadine and are highly unlikely to occur with ingestion of a single dose. (clinicaltrials.gov)
  • 300 mg of anhydrous caffeine PO as a single dose may be effective for the treatment of post-dural puncture headache (PDPH) in some patients, although the data are limited. (pdr.net)
  • max single dose: 150mg (give 400mg/day as 100mg 4 times daily at least 4hrs apart). (empr.com)
  • PO 200 mg/day as single dose or 100 mg twice daily. (drugster.info)
  • To help with nausea and vomiting, administer trimethobenzamide (Tigan) 300 mg PO TID or a similar antiemetic, started 3 days prior to the initial dose of apomorphine and continued at least during the first two months of therapy. (brainscape.com)
  • In your case, if your nausea and tiredness are a part of anxiety or depression , it may help, at a standard dose. (healthtap.com)
  • They found that amantadine prevented 61% (95% confidence interval, 35-76) of influenza A cases and 25% (95% CI, 13-36) of cases of influenza-like illness, but caused nausea (odds ratio 2.56, 1.37-4.79), insomnia and hallucinations (OR 2.54, 1.50-4.31), as well as withdrawals due to adverse events (OR 2.54, 1.60-4.06). (medpagetoday.com)
  • A small number of suicidal attempts, some of which have been fatal, have been reported in patients treated with amantadine. (pediatriconcall.com)
  • Amantadine, 200 mg, or placebo was each administered for 6 weeks (12 weeks total) to patients who were recruited consecutively. (nih.gov)
  • Patients over 65 years old may have a stronger reaction and need a smaller dose. (nationwidechildrens.org)
  • Maximum dose: 400 mg/day, given as 200 mg twice daily, for patients not responding to 300 mg/day. (nih.gov)
  • It is important for physicians to assess patients for constipation, particularly within four to five days of initial dosing or after a dose increase. (prnewswire.com)
  • Chronic therapy with amantadine annulled differences in CSP duration between controls and patients, possibly through restoration of more physiological levels of intracortical inhibition in the motor cortex. (hindawi.com)
  • The usefulness of amantadine as an anti-parkinsonian drug is somewhat limited by the need to screen patients for a history of seizures and psychiatric symptoms. (wikipedia.org)
  • Rare cases of severe skin rashes, such as Stevens-Johnson syndrome, and of suicidal ideation have also been reported in patients treated with amantadine. (wikipedia.org)
  • Patients treated with amantadine can experience intense urges (sexual, gambling, spending money uncontrollably). (rxwiki.com)
  • In a provocative, randomised, controlled study of 60 patients who had failed interferon monotherapy, Brillianti and colleagues 6 claimed sustained viral clearance in 19 of 40 patients (48%) with triple therapy of interferon alfa-2b, ribavirin, and amantadine compared with only 1 of 20 patients (5%) who received a combination of interferon alfa 2b and ribavirin. (bmj.com)
  • Buy Amantadine no Prescription In published studies, amantadine reduced serum prolactin levels and the symptoms of galactorrhea in patients taking neuroleptic drugs. (unionsentinel.com)
  • Patients hypersensitive to amantadine should not be given the drug. (healthyplace.com)
  • Amantadine can exacerbate mental problems in patients with a history of psychiatric disorders or substance abuse. (healthyplace.com)
  • Because of the possibility of serious adverse effects, caution should be observed when prescribing amantadine to patients being treated with drugs having CNS effects, or for whom the potential risks outweigh the benefit of treatment. (healthyplace.com)
  • Because some patients have attempted suicide by overdosing with amantadine, prescriptions should be written for the smallest quantity consistent with good patient management. (healthyplace.com)
  • The dose of amantadine should be reduced in patients with renal impairment and in patients who are 65 years of age or older. (healthyplace.com)
  • Care should be exercised when administering amantadine to patients with liver disease, a history of recurrent eczematoid rash, or to patients with psychosis or severe psychoneurosis not controlled by chemotherapeutic agents. (healthyplace.com)
  • Patients were assigned to receive placebo or one of three dose levels of ADS-5102. (cnbc.com)
  • Patients may also experience symptoms of their disease upon waking, prior to the first dose of levodopa taking effect. (cnbc.com)
  • Amantadine-treated patients (n = 250) were similar to the patients not treated with amantadine (n = 586) in terms of age, gender, type of parkinsonism, Hoehn and Yahr stage and dementia status at initial neurological visit. (neurology.org)
  • Although most patients experience symptomatic improvement with amantadine, the mechanism for this response is uncertain. (neurology.org)
  • On the basis of the clinical studies, the recommended dose for patients over the age of 65 years is 20 mg per day (20mg once a day) as described above. (medicines.org.uk)
  • In patients with mildly impaired renal function (creatinine clearance 50 80 ml/min) no dose adjustment is required. (medicines.org.uk)
  • In patients with moderate renal impairment (creatinine clearance 30 49 ml/min) daily dose should be 10 mg per day. (medicines.org.uk)
  • Short courses of corticosteroids (total daily dose of 30 mg/day for 12 weeks), followed by a taper, showed improvement versus placebo in patients (n = 23) with early or acute CRPS. (uspharmacist.com)
  • 20 to 60 mg/kg/day PO or 900 mg/m2/day PO, given in divided doses every 6 hours. (pdr.net)
  • up to 300 mg/day may be given in divided doses. (drugster.info)
  • The main finding is that on every single behavioral domain measured, we had a higher incidence of recovery in the amantadine group than in the placebo group," said Dr. Giacino, who is now at Harvard's Spaulding Rehabilitation Hospital . (nytimes.com)
  • At the end of treatment, HCV RNA clearance was seen in 32.9% of the amantadine group and 38.4% of the placebo group (p = 0.3). (bmj.com)
  • In treatment, amantadine significantly shortened duration of fever compared with placebo (by 0.99 days, -1.26 to -0.71), but had no effect on nasal shedding of influenza A viruses (0.93, 0.71-1.21)," the authors wrote. (medpagetoday.com)
  • Although a few early reports 4 claimed a good response to amantadine monotherapy, subsequent studies have failed to confirm these observations. (bmj.com)
  • In conjunction with the vaccine, administer amantadine for 2 to 3 wk after vaccination. (drugster.info)
  • HHS Secretary Tommy G. Thompson said today that about 60 million doses of influenza vaccine combined with an ample supply of antiviral medicines -- potentially enough for more than 40 million people during the flu season -- puts America in a strong position to keep people safe during the upcoming flu season. (archives.gov)
  • Secretary Thompson said the nation's cache of vaccine and medicines includes an additional 2.6 million doses of influenza vaccine that Aventis said today it will make available in January. (archives.gov)
  • In addition to the 60 million doses of influenza vaccine, we have healthy supplies of antiviral medicines to help keep you safe from the flu,' Secretary Thompson said. (archives.gov)
  • In addition, about 24 million doses of this influenza vaccine supply has yet to be distributed and will be steered toward the people and places who need it the most. (archives.gov)
  • We are still in the early stages of the flu season, and millions more doses of the vaccine will be shipped in coming weeks, so there is still time to get vaccinated,' Secretary Thompson said. (archives.gov)
  • The Secretary said the supply of 60 million doses of influenza vaccine includes about 58 million doses of Aventis vaccine and 2 million doses of FluMist nasal spray, and there is some potential more doses may be secured from other sources. (archives.gov)
  • If you are even few hours late with the low dose pill, your estrogen levels can drop to a level you can ovulate which can result in pregnancy . (healthtap.com)
  • Amantadine Cheap Online no Prescription Du er her: Best Places to Buy Amantadine Online This medicine may be prescribed to treat glaucoma - a disease of the eye that increases intraocular pressure and produces defects in the field of vision. (unionsentinel.com)
  • Verapamil therapy was continued to treat his hypertension, but the hydrochlorothiazide, duloxetine, ziprasidone, and amantadine therapies were withheld. (mdmag.com)