Dose-Response Relationship, Drug

Time Factors

Dose-Response Relationship, Radiation

Oxytropis

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Stages Of Reality Theatricality In Cinema

Elimination diet

Hydroxychloroquine

Microbiota

Pandemrix

Genetically modified food controversies

Food allergy

Acute disseminated encephalomyelitis

Lipopolysaccharide

Vaccine hesitancy

Reproductive immunology

Immune system

Immunologic adjuvant

Ataxia-telangiectasia

Adoptive cell transfer

Opsoclonus myoclonus syndrome

Postural orthostatic tachycardia syndrome

Psoriasis

Estramustine phosphate

Cholestasis

Cockroach

Antibody

Multiple sclerosis research

Susan Zolla-Pazner

Alcoholism

Kawasaki disease

Focal infection theory

Anthony Fauci

Stimulant

Pemphigoid

Lyme disease

Antibody

Adenosine A2A receptor

Cat food

Human Endogenous Retrovirus-W

Antigen6

• Serum IgA and IgG titers were increased at the higher antigen doses (25 or 50 µg) but the percent with 4-fold increases was at best 38% for both IgA and IgG. (emmes.com)
• 0·0001) responses to the MERS-CoV spike antigen was observed at all doses. (ox.ac.uk)
• LYMPHOCYTE ACTIVATION by a specific ANTIGEN thus triggering clonal expansion of LYMPHOCYTES already capable of mounting an immune response to the antigen. (ucdenver.edu)
• No viral replication was detectable in the nose of any of the eight animals in the 100-µg dose group by day 2 after challenge, and limited inflammation or detectable viral genome or antigen was noted in lungs of animals in either vaccine group. (bvsalud.org)
• Prednisone also inhibits antigen presentation, T lymphocyte activity, and (at higher doses) antibody production. (medscape.com)
• Successful long-term HAART results in a gradual recovery of CD4 T-cell numbers and an improvement of immune responses and T-cell repertoire (previously lost antigen responses may be restored). (medscape.com)

Antibody responses2

• The serum anti-dmLT IgA and IgG and neutralizing antibody responses were modest after any of the SL immunizations. (emmes.com)
• Here we show that mRNA-1273 induces potent neutralizing antibody responses to both wild-type (D614) and D614G mutant2 SARS-CoV-2 as well as CD8+ T cell responses, and protects against SARS-CoV-2 infection in the lungs and noses of mice without evidence of immunopathology. (bvsalud.org)

Antibodies2

• Neutralising antibodies against live MERS-CoV were observed in four (44% [95% CI 19-73]) of nine participants in the high-dose group 28 days after vaccination, and 19 (79% [58-93]) of 24 participants had antibodies capable of neutralisation in a pseudotyped virus neutralisation assay.InterpretationChAdOx1 MERS was safe and well tolerated at all tested doses. (ox.ac.uk)
• dogs with vigorous initial responses resisted oronasal CPV challenge exposure 6 months after vaccination, and hemagglutination-inhibiting antibodies persisted in such dogs for greater than 1 year. (snowleopardnetwork.org)

Vaccine dose3

• The frequency of IgA- or IgG-ASCs in circulation were somewhat vaccine dose dependent and were detected at a moderate level. (emmes.com)
• The first vaccine dose induced protection from infection from the circulating alpha (B.1.1.7) variant over several weeks. (ox.ac.uk)
• Six-Month Follow-up after a Fourth BNT162b2 Vaccine Dose. (cdc.gov)

Safe and well tolerated1

• Noting that 4 (21%) of the 19 patients allocated to high-dose vitamin D had to stop (n = 3) or reduce (n = 1) the treatment because of side effects, he said, "I would be cautious to conclude that the study provides conclusive evidence that supplementation with 10,400 IU/day is safe and well-tolerated, as this statement may induce some MS patients to take this relatively high dose without appropriate supervision. (medscape.com)

Vaccination7

• Vaccination induced type 1 helper T-cell (Th1)-biased CD4 T-cell responses and low or undetectable Th2 or CD8 T-cell responses. (bvsalud.org)
• But in a two-year study, Irwin, the first author of the research and director of the UCLA Cousins Center for Psychoneuroimmunology, and his colleagues measured immune responses to the shingles vaccination among 40 people aged 60 or older who suffered from a major depressive disorder and compared these responses to similar levels in 52 control patients matched by age and gender. (ucla.edu)
• Efforts are also needed to identify and diagnose depressed elderly patients who might benefit from either a more potent vaccine or a multi-dose vaccination schedule. (ucla.edu)
• The other immune function parameters including responses to systemic tetanus and oral typhoid vaccination, phagocytosis, oxidative burst, lymphocyte proliferation and lymphocyte subset distribution were neither affected by the consumption of micronutrients nor by the consumption of bovine colostrum concentrate. (biomedcentral.com)
• Adverse reactions were not associated with living FPLV vaccination, and FPLV did not interfere with simultaneous response to attenuated canine distemper virus. (snowleopardnetwork.org)
• In this prospective cohort study, a third dose of the BNT162b2 vaccine led to an improved and sustained immunologic response as compared with two doses, but the additional immunologic advantage of the fourth dose was much smaller and had waned completely by 13 weeks after vaccination. (cdc.gov)
• This finding correlated with waning vaccine effectiveness among recipients of a fourth dose, which culminated in no substantial additional effectiveness over a third dose at 15 to 26 weeks after vaccination. (cdc.gov)

Clinical8

• With respect to the skin, dose- response relationships and no-effect levels were found for both intradermal and topical induc- tion, as well as for intradermal and topical elicitation of allergenic responses in epidemiological, clinical, and animal studies. (cdc.gov)
• Polyfunctional HIV-specific T cell responses are a hallmark of non-progressive HIV-2 infection and may be related to good clinical outcome in this setting. (ox.ac.uk)
• Retrospectively, we studied the relationship among anti-PnPs IgG response to 3 doses of Prevenar®13, levels of immune system components, leukocyte populations, and clinical data in children with ID. (bvsalud.org)
• We aimed to identify clinical characteristics and biomarkers associated with response to high-dose interleukin-2 therapy (IL-2) in patients with metastatic melanoma and renal cell carcinoma treated at an academic community hospital. (springeropen.com)
• We evaluated clinical characteristics: metastatic sites of disease, prior therapies, number of IL-2 doses per cycle, response duration, autoimmune phenomena, and peak fever, as well as laboratory biomarkers: baseline LDH, platelet nadir, and baseline and highest absolute lymphocyte count (ALC). (springeropen.com)
• The clinical benefit group developed autoimmune phenomena (melanoma patients), lower platelet nadir, and on average, received the same number of IL-2 doses as the no clinical benefit group, suggesting a response relationship to the patient's baseline immune status. (springeropen.com)
• These results clearly indicated that aPD-L1 mAb required higher doses than aPD-1 mAb in clinical setting. (bmj.com)
• These are used to improve the clinical and immunologic aspects of the disease. (medscape.com)

Virologic3

• Initiation of therapy in the asymptomatic person is more complex and involves consideration of multiple virologic, immunologic, and psychosocial factors. (cdc.gov)
• Although the pathogenesis of HIV infection and the general virologic and immunologic principles underlying the use of antiretroviral therapy are similar for all HIV-infected persons, unique therapeutic and management considerations apply to HIV-infected children. (cdc.gov)
• In addition to virologic response and reduced risk for opportunistic infection, evidence suggests that non-AIDS-defining illnesses, in particular psychiatric and renal disease, may also be reduced when on HAART. (medscape.com)

Immunogenic2

• The dmLT vaccine formulation evaluated here was safe but only moderately immunogenic at doses up to 50 µg when administered by the SL or oral route. (emmes.com)
• These data on dynamic cellular and humoral responses indicate that extension of the dosing interval is an effective immunogenic protocol. (ox.ac.uk)

BNT162b22

• Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine. (ox.ac.uk)
• Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose. (ox.ac.uk)

Lymphocyte1

• changes were also prevented by administering cyclophosphamide, a drug which in low dose might inhibit proliferation of suppressor lymphocyte populations. (deepdyve.com)

Immune responses1

• Heterologous prime-boost immunization strategies can evoke powerful T cell immune responses and may be of value in developing an improved tuberculosis vaccine. (ox.ac.uk)

Immunity1

• However, unlike the long- lived (greater than or equal to 20-month) immunity engendered by CPV infection, the response of dogs to living FPLV was variable. (snowleopardnetwork.org)

Humoral1

• A single dose was able to elicit both humoral and cellular responses against MERS-CoV. (ox.ac.uk)

Immunization3

• The earliest detectable response was in peripheral blood mononuclear cell cultures obtained 6 to 8 days after immunization. (nih.gov)
• A Phase 1 dose escalating study of double mutant heat-labile toxin LTR192G/L211A (dmLT) from Enterotoxigenic Escherichia coli (ETEC) by sublingual or oral immunization. (emmes.com)
• A comparison of intranasal (i.n.) and parenteral immunization of BCG showed that while both routes elicited comparable T cell responses in the spleen, only i.n. delivery elicited specific T cell responses in the lung lymph nodes, and these responses were further boosted by i.n. delivery of M.85A. (ox.ac.uk)

Infection6

• Three immunizations using two different doses, 3 or 6 micrograms per dose, provided partial or complete protection in macaques against SARS-CoV-2 challenge, respectively, without observable antibody-dependent enhancement of infection. (unboundmedicine.com)
• Prior SARS-CoV-2 infection amplified and accelerated the response. (ox.ac.uk)
• Polyfunctional T cell responses are a hallmark of HIV-2 infection. (ox.ac.uk)
• Although correlations between decreased DTH and enhanced risk of certain infection have been reported, it remains unclear whether and enhanced DTH response actually improves immune defense. (biomedcentral.com)
• in particular, the function of Tregs, which are responsible for initial response to infection [ 20 ], is important in these virus infections which play a pivotal role in immune regulation and are integral to the control of allergic responses [ 21 ]. (termedia.pl)
• Individual response to Toxoplasma infection is determined by immune status, timing of infection, and the genetic composition of the host and the organism ( 4 ). (cdc.gov)

Titers2

• Measurement of anti-pneumococcal capsular polysaccharides (anti-PnPs) IgG titers is an important tool in the immunologic assessment of patients with suspected immunodeficiency disorders (ID) to reduce the morbi-mortality and minimize severe infections. (bvsalud.org)
• RESULTS: The mRNA-1273 vaccine candidate induced antibody levels exceeding those in human convalescent-phase serum, with live-virus reciprocal 50% inhibitory dilution (ID50) geometric mean titers of 501 in the 10-µg dose group and 3481 in the 100-µg dose group. (bvsalud.org)

20191

• Researchers at the University of Washington and Stanford University School of Medicine have reported a significant inverse relationship between current smoking and coronavirus disease 2019 (COVID-19) mortality rates across forty countries. (news-medical.net)

Single dose2

• In a substudy of 589 individuals, we show that this single dose induces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (NAb) responses and a sustained B and T cell response to the spike protein. (ox.ac.uk)
• A single dose of ChAdOx1 MERS was safe at doses up to 5 × 1010 viral particles with no vaccine-related serious adverse events reported by 12 months. (ox.ac.uk)

Factors3

• Efforts should also be made to gauge the effects of such factors as immunologic surveillance and chemical cocarcinogens on ultraviolet photocarcinogenesis. (cdc.gov)
• There was a synergistic relationship between these two risk factors, with the risk of mood disorders further increased with both risk factors (IRR, 2.35). (doctorslounge.com)
• The researchers examined the relationship between mortality rates and national smoking prevalence after adjustment for known risk factors associated with COVID-19 mortality and after adjustment for independent variables including gender ratio, obesity prevalence, age over 65 years, and average ambient temperature. (news-medical.net)

Viral2

• Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial. (ox.ac.uk)
• Participants received a single intramuscular injection of ChAdOx1 MERS at three different doses: the low-dose group received 5 × 109 viral particles, the intermediate-dose group received 2·5 × 1010 viral particles, and the high-dose group received 5 × 1010 viral particles. (ox.ac.uk)

Infections1

• A dose-response association was noted, with the number of infections and autoimmune diseases increasing the risk of mood disorders. (doctorslounge.com)

Cells7

• The response of lymph node and spleen cells tended to lag behind that of peripheral blood cells at the earlier time intervals. (nih.gov)
• NAb levels were higher after the extended dosing interval (6-14 weeks) compared with the conventional 3- to 4-week regimen, accompanied by enrichment of CD4+ T cells expressing interleukin-2 (IL-2). (ox.ac.uk)
• This study aimed to examine if nobiletin, which is found in the peel of citrus fruits, could inhibit inflammatory responses in interleukin (IL)-1β-stimulated human periodontal ligament cells (HPDLCs). (tokushima-u.ac.jp)
• The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions. (nih.gov)
• In terms of immunologic effects, patients taking the high dose of cholecalciferol showed a reduction in the proportion of interleukin (IL)-17 CD4+ T cells, CD161 CD4+ T cells, and effector memory CD4+ T cells, which are believed to be major contributors to the immunopathogenesis of MS. The high-dose group also showed a concomitant increase in the proportion of central memory CD4+ T cells and naive CD4+ T cells. (medscape.com)
• It Much was The Cold War: with response of reported normal T-cells( country) and united suppressive cells in wide discoveries. (michael-noeres.de)
• Following this discovery, further research led to the discovery of Kulchitsky cells in the bronchial epithelium and establishing a relationship between them and different types of LNETs. (spandidos-publications.com)

Relatively high1

• cal to induce skin and/or respiratory allergy at relatively high doses. (cdc.gov)

Immunodeficiency1

• however, immunocompromised immunocompromised A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation. (lecturio.com)

Organism2

• A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell. (bvsalud.org)
• This article describes the inversion of effects, a widespread medical phenomenon, through three possible mechanisms: non-linearity of dose-response relationship, different initial pathophysiological states of the organism, and pharmacodynamics of body response to the medicine. (hpathy.com)

Performed to evaluate1

• A literature study was performed to evaluate dose-response relationships and no-effect levels for sensitization and elicitation in skin- and respiratory allergy. (cdc.gov)

Adult1

• We performed a Phase 1, dose escalation study (1-50 µg) evaluating the sublingual (SL) delivery of the double mutant heat-labile toxin LTR192G/L211A (dmLT) in 80 healthy adult volunteers. (emmes.com)

High-dose group3

• This study is registered with ClinicalTrials.gov, NCT03399578.FindingsBetween March 14 and Aug 15, 2018, 24 participants were enrolled: six were assigned to the low-dose group, nine to the intermediate-dose group, and nine to the high-dose group. (ox.ac.uk)
• All participants were available for follow-up at 6 months, but five (one in the low-dose group, one in the intermediate-dose group, and three in the high-dose group) were lost to follow-up at 12 months. (ox.ac.uk)
• Baseline levels of serum 25(OH)D were 27 ng/mL in both groups, but the high-dose group had a much greater increase (mean increase of 34.9 ng/mL) compared with the low-dose group (6.9 ng/mL). (medscape.com)

Efficacy3

• We collected data from 2 phase 3 induction studies and 1 maintenance study to determine ustekinumab's pharmacokinetic features, relationship between exposure and response, and optimal serum concentrations for efficacy. (birmingham.ac.uk)
• METHODS: We collected data on serum concentrations of ustekinumab and efficacy from induction studies of patients with moderate to severe CD given ustekinumab for 8 weeks following a single intravenous dose (either 130 mg or approximately 6 mg/kg). (birmingham.ac.uk)
• CONCLUSIONS: In an analysis of data from phase 3 studies of patients with moderate to severe CD, we found serum concentrations of ustekinumab to be proportional to dose and associate with treatment efficacy. (birmingham.ac.uk)

Higher2

• Studies at higher doses with better formulations appear warranted. (emmes.com)
• According to the GINA report " Global Strategy for Asthma Management and Prevention ," higher blood eosinophils is a strong predictor of a good response to targeted biologic therapy. (medscape.com)

Dosage1

• Subjects receiving the first dose at each dosage level were observed overnight in a research facility. (emmes.com)

Intradermal1

• In addition, the observed dose-response relationships and threshold values have been obtained by a wide variety of test methods using different techniques, such as intradermal exposure versus topical or inhalation exposure at the workplace, or using different endpoints, which all appear important for the outcome of the test. (cdc.gov)

Epidemiological4

• Although dose-response relationships for elicitation were found in some epidemiological studies, concentration-response relationships were present only in a limited number of animal studies. (cdc.gov)
• Benchmark Dose Model-- A statistical dose-response model applied to either experimental toxicological or epidemiological data to calculate a BMD. (cdc.gov)
• Case-Control Study-- A type of epidemiological study that examines the relationship between a particular outcome (disease or condition) and a variety of potential causative agents (such as toxic chemicals). (cdc.gov)
• Cross-sectional Study-- A type of epidemiological study of a group or groups of people that examines the relationship between exposure and outcome to a chemical or to chemicals at one point in time. (cdc.gov)

Patients15

• These associations are compatible with the hypothesis of a general immunologic response affecting the brain in subgroups of patients with mood disorders. (doctorslounge.com)
• Further investigation of immune predictors of response may be useful to select appropriate patients for this therapy. (springeropen.com)
• Depressed patients not being treated with antidepressants showed a weaker immune response to the varicella-zoster virus - and thus were less able to respond to the shingles vaccine - than patients who were not depressed and patients who suffered from depression but were receiving treatment with antidepressants. (ucla.edu)
• Larger studies are needed to evaluate the possible relationship between untreated depression and the risk of shingles, the study noted, along with further research to establish what mechanisms are responsible for patients' reduced immune response. (ucla.edu)
• These patients respond readily to hydrocortisone, suggesting that an inadequate hypothalamic-pituitary-adrenal (HPA) response to stress may be a major cause [2-4]. (scirp.org)
• Patients with multiple sclerosis (MS) who took high doses of cholecalciferol (vitamin D3) had increased blood levels of 25-hydroxyvitamin D levels [25(OH)D] to those proposed to be sufficient in MS and showed promising immunologic changes, in a new study. (medscape.com)
• They conducted the current study to investigate the immunologic effects of high-dose vitamin D in patients with MS. (medscape.com)
• For the study, 40 patients with relapsing-remitting MS were randomly assigned to receive high-dose (10,400 IU) or low-dose (800 IU) cholecalciferol daily for 6 months. (medscape.com)
• The study identifies some potential mechanisms by which vitamin D could affect the course of MS, but it does not provide evidence on whether supplementation at this high dose is beneficial to patients with MS," he noted. (medscape.com)
• Interview topics included: experiences in the treatment of people living with HIV/AIDS, relationship and dialogue with patients, barriers/facilitators to adherence, and effectiveness of available services. (scielo.br)
• We collected the same data from a maintenance study of patients with a response to ustekinumab in the induction study who then received subcutaneous injections (90 mg) every 8 or 12 weeks for 44 weeks. (birmingham.ac.uk)
• I. To determine the maximum tolerated dose (MTD) and preliminary safety of hydroxychloroquine (HCQ) when administered with gemcitabine and docetaxel (G+D) in patients with recurrent/metastatic osteosarcoma. (clinicaltrials.gov)
• I. To determine the objective response rate by Response Evaluation Criteria in Solid Tumors (RECIST) of the combination of G + D + HCQ in patients with recurrent/metastatic osteosarcoma. (clinicaltrials.gov)
• I. To describe the metabolic response rates of G + D + HCQ in patients recurrent/metastatic measurable osteosarcoma by positron emission tomography (PET)/computed tomography (CT) at 6 weeks. (clinicaltrials.gov)
• online The Cold to run the response of our balancing patients and seats is known naturally not its manner but greatly its next malware and how-to flow. (michael-noeres.de)

Adverse3

• Benchmark Dose (BMD)-- Usually defined as the lower confidence limit on the dose that produces a specified magnitude of changes in a specified adverse response. (cdc.gov)
• Dose-Response Relationship-- The quantitative relationship between the amount of exposure to a toxicant and the incidence of the adverse effects. (cdc.gov)
• The points in the figures showing no-observed-adverse-effect levels (NOAELs) or lowest observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)

Inverse1

• Current evidence from observational studies suggests an inverse relationship between circulating vitamin D concentrations and risk of type 2 diabetes mellitus. (oregonstate.edu)

Administration1

• Sufficient accumulation of aPD-L1 mAb in tumors was achieved by administration at a high dose owing to the saturation of target-mediated binding in healthy organs. (bmj.com)

Spleen1

• The PK study showed that aPD-L1 mAb was accumulated largely in normal organs such as the spleen, liver, and kidney, resulting in low blood concentration and low distributions to tumors at a low dose, even though the tumors expressed PD-L1. (bmj.com)

Levels6

• With respect to the respiratory tract, dose-response rela- tionships and no-effect levels for induction were found in several human as well as animal studies. (cdc.gov)
• Notwithstanding the observation of dose-response relationships and no-effect levels, due to a number of uncertainties, no definite conclusions can be drawn about absolute threshold values for allergens with respect to sensitization of and elicitation reactions in the skin and respiratory tract. (cdc.gov)
• Therefore, especially with re- gard to respiratory allergy, standardized and validated dose-response test methods are urgently required in order to be able to recommend safe exposure levels for allergens at the workplace. (cdc.gov)
• Preliminary evidence is suggesting that even ultra-low doses and high-dilutions of drugs may incorporate structural or frequency information and interact with chaotic dynamics and physical-electromagnetic levels of regulation. (hpathy.com)
• The authors explain that optimal levels of serum 25(OH)D in MS are currently unclear, but it has been proposed that levels between 40 and 60 ng/mL may be the best target for this population, which such levels being achieved with the high dose of cholecalciferol given in this study, but not with the low dose. (medscape.com)
• However, there are few data on its pharmacokinetic properties or the relationship between drug exposure levels and patient response. (birmingham.ac.uk)

Cellular1

• Reorganization of regulation systems, through a coherent response to the medicine, could pave the way to the healing of the cellular, tissue and neuro-immuno-endocrine homeodynamics. (hpathy.com)

Inflammatory1

• Used for its medicinal effects for centuries and extensively studied, Curcumin has been shown to help maintain the bodys normal inflammatory response while also supporting joint, liver, gastrointestinal, and cardiovascular function. (healthywithjodi.com)

Cell6

• A systematic study using Sk-1-hairless-mice was made of the dependence of squamous cell cancer development on ultraviolet (UV) wavelength distribution, total dose, and dose fractionation in a manner simulating solar radiation at various stages of ozone depletion. (cdc.gov)
• Here, we report a detailed assessment of the HIV-2-specific CD4(+) and CD8(+) T cell response compared to HIV-1, using polychromatic flow cytometry to assess the quality of the HIV-specific T cell response by measuring IFN-gamma, IL-2, TNF-alpha, MIP-1beta, and CD107a mobilization (degranulation) simultaneously following Gag peptide stimulation. (ox.ac.uk)
• We show that recombinant modified vaccinia virus Ankara, expressing Mycobacterium tuberculosis Ag 85A (M.85A), strongly boosts bacille Calmette-Guérin (BCG)-induced Ag 85A specific CD4(+) and CD8(+) T cell responses in mice. (ox.ac.uk)
• Antibody and T-cell responses were assessed before upper- and lower-airway challenge with SARS-CoV-2. (bvsalud.org)
• Immunotherapy in the treatment of metastatic melanoma and renal cell carcinoma can produce durable therapeutic responses, which may improve survival. (springeropen.com)
• Mercy Medical Center secures top rank from Healthgrades for surgical care in Maryland, Investigational vaccine regimen safe but did not provide protection against HIV acquisition, Researchers use single-cell RNA-sequencing to study the aging peripheral blood in mice, Accurate information about what most other people are doing can boost vaccine uptake, Study sheds new light on how the B cell academy mounts a diverse immune response. (quartiersdaffaires.fr)

Duration1

• LOAELs or NOAELs should also help in determining whether or not the effects vary with dose and/or duration, and place into perspective the possible significance of these effects to human health. (cdc.gov)

Systemic1

• Based on the systemic networks which play an important role in response to stress, a unitary and general model is designed: homeopathic medicines could interact with sensitive (primed) regulation systems through complex information, which simulate the disorders of natural disease. (hpathy.com)

Tumor5

• The findings suggested that photocarcinogenesis is a dynamic process with no simple relationship existing between erythema and tumorigenic responses, nor is there a simple relationship between spectral distribution with possible waveband interactions, total dose, and dose fractionation as they relate to tumor production. (cdc.gov)
• The PK of the mAbs in the tumor-bearing mice was investigated at low and high doses using two radioisotopes (Indium-111 and Iodine-125) to evaluate the accumulation and degradation of the mAbs. (bmj.com)
• Results aPD-1 mAb showed antitumor effect in a dose-dependent manner, indicating that the tumor model was sensitive to PD-1/PD-L1 blockade therapy, whereas aPD-L1 mAb failed to suppress tumor growth. (bmj.com)
• To assess the relationship between probability of response and/or disease control and tumor HSP27, pHSP27, ALDH1A1, and HLTF expression. (clinicaltrials.gov)
• To complete functional proteomic profiling of autophagic and apoptotic pathways on tumor samples by RPPA and correlate findings with the probability response and disease control. (clinicaltrials.gov)

Drug1

• when caused by a drug, this is regarded as an expression of iatrogenic response or pathophysiological reaction ('proving' in the homeopathic medical system). (hpathy.com)

Mechanisms1

• Besides, reactive oxygen species-driven oxidative stress and associated inflammation seem to be plausible underlying mechanisms, eliciting various unfavorable responses. (dovepress.com)

General1

• Material y métodos: estudio observacional prospectivo y analítico sobre una muestra de pacientes con cáncer de mama confirmado histológicamente, atendidas en el Hospital General de Valencia (enero 2017-noviembre 2018). (bvsalud.org)

Specific3

• Speak with a healthcare provider to find out what dose might be best for a specific condition. (medlineplus.gov)
• e)Low doses or high dilutions of a substance which is capable of evoking certain symptoms in healthy subjects, when administered to subjects showing similar symptoms due to natural diseases, may evoke a specific and global secondary healing reaction, thus becoming a potentially effective therapeutic agent. (hpathy.com)
• The same GINA report provides specific guidance on eligibility and dosing. (medscape.com)

Studies5

• Cancer Effect Level (CEL)-- The lowest dose of chemical in a study, or group of studies, that produces significant increases in the incidence of cancer (or tumors) between the exposed population and its appropriate control. (cdc.gov)
• While we know that psychological stress is associated with a weakened immune response to influenza vaccines in older adults, few studies have examined the association between depression and infectious disease risk, or disease-relevant immunologic endpoints, such as vaccine responses," he said. (ucla.edu)
• Conclusion According to the PK studies, aPD-1 mAb showed linear PK, whereas aPD-L1 mAb showed non-linear PK between low and high doses. (bmj.com)
• RESULTS: Serum concentrations of ustekinumab over time were proportional to dose and did not differ significantly between the induction studies. (birmingham.ac.uk)
• This phase I/II trial studies the side effects and best dose of hydroxychloroquine and how well it works when given together with gemcitabine and docetaxel in treating participants with osteosarcoma that has come back or does not respond to treatment. (clinicaltrials.gov)

Concentration1

• Ustekinumab concentration data were categorized into quartiles and relationships between exposure and response were assessed. (birmingham.ac.uk)

Disease1

• The immune response in periodontal lesions is involved in the progression of periodontal disease. (tokushima-u.ac.jp)

Strain1

• To decipher the relationship between the current outbreak strain and other toxigenic O1 El Tor strains from the ongoing seventh pandemic of cholera, we sequenced the isolate obtained on September 30, 2022, along with four isolates obtained in 2021 and 2022 from Dhaka, Bangladesh. (cdc.gov)

Phase2

• OUTLINE: This is a phase I, dose-escalation study of hydroxychloroquine followed by a phase II study. (clinicaltrials.gov)
• Visual evoked potentials often show a loss of P100 response in the acute phase. (medscape.com)