Microbial Sensitivity Tests
Drug Resistance, Microbial
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Urinary Tract Infections
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
Anti-Infective Agents, Urinary
Topoisomerase II Inhibitors
DNA Topoisomerases, Type II
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Drug Resistance, Bacterial
A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
DNA Topoisomerase IV
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
Derivatives of phenylacetic acid. Included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. Note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the PHENOL ester of ACETIC ACID.
DYSENTERY caused by gram-negative rod-shaped enteric bacteria (ENTEROBACTERIACEAE), most often by the genus SHIGELLA. Shigella dysentery, Shigellosis, is classified into subgroups according to syndrome severity and the infectious species. Group A: SHIGELLA DYSENTERIAE (severest); Group B: SHIGELLA FLEXNERI; Group C: SHIGELLA BOYDII; and Group D: SHIGELLA SONNEI (mildest).
Drug Resistance, Multiple, Bacterial
Carbonyl Cyanide m-Chlorophenyl Hydrazone
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
Lethal Dose 50
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Chromatography, High Pressure Liquid
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Bacterial Outer Membrane Proteins
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
Drug Administration Schedule
SOS Response (Genetics)
An error-prone mechanism or set of functions for repairing damaged microbial DNA. SOS functions (a concept reputedly derived from the SOS of the international distress signal) are involved in DNA repair and mutagenesis, in cell division inhibition, in recovery of normal physiological conditions after DNA repair, and possibly in cell death when DNA damage is extensive.
Colony Count, Microbial
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.
Eye Infections, Bacterial
Multidrug Resistance-Associated Proteins
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
Drug Resistance, Multiple
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Dose-Response Relationship, Radiation
Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Cell Membrane Permeability
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Membrane Transport Proteins
Area Under Curve
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Radiotherapy Planning, Computer-Assisted
Rats, Inbred Strains
Gene Expression Regulation, Bacterial
Magnetic Resonance Spectroscopy
Relative Biological Effectiveness
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Drug Therapy, Combination
Sequence Analysis, DNA
Metered Dose Inhalers
The observation, either continuously or at intervals, of the levels of radiation in a given area, generally for the purpose of assuring that they have not exceeded prescribed amounts or, in case of radiation already present in the area, assuring that the levels have returned to those meeting acceptable safety standards.
Metabolic Clearance Rate
Antineoplastic Combined Chemotherapy Protocols
Amino Acid Sequence
Disease Models, Animal
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
Organs at Risk
Dose-Response Relationship, Immunologic
Dose-Response Relationship, Drug
"Absorption of norfloxacin is rapid following single doses of 200 mg, 400 mg and 800 mg. At the respective doses, mean peak ... Steady-state concentrations of norfloxacin will be attained within two days of dosing. Renal excretion occurs by both ... Fecal recovery accounts for another 30% of the administered dose. Two to three hours after a single 400-mg dose, urinary ... The urinary pH may affect the solubility of norfloxacin. Norfloxacin is least soluble at urinary pH of 7.5 with greater ...
It is available as a generic medication and not very expensive. Wholesale it costs between 0.03 and 0.13 USD a dose. ... The oral tablet form of ciprofloxacin was approved in October 1987, just one year after the approval of norfloxacin. In ... The fluoroquinolone program at Bayer focused on examining the effects of very minor changes to the norfloxacin structure.[ ... The serum half-life of ciprofloxacin is about 4-6 hours, with 50-70% of an administered dose being excreted in the urine as ...
Infection results from the ingestion of contaminated food or water, and the infective dose can be as low as 800 organisms. To ... or norfloxacin. Fluid replacement via oral rehydration salts may be needed and intravenous fluid may be required for serious ...
Isolates are believed to be sensitive in vitro but not in vivo due to the inability of the drug to reach therapeutic doses ... However, some susceptibility has also been shown to ampicillin, amoxicillin, penicillin, ceftiofur, enrofloxacin, norfloxacin, ...
"Thyrolar (liotrix) dosing, indications, interactions, adverse effects, and more". "FDA Drug Safety Communication: FDA approves ... Included were the popular drugs Cipro (ciprofloxacin), Levaquin (levofloxacin), Avelox (moxifloxacin), Noroxin (norfloxacin) ... Euthyroid populations demonstrate increased CV risk at clinical doses. Hypothyroid agents should not be used in combination ...
The standard regimen for complicated UTIs is an oral 3g dose administered once every 48 or 72 hours for a total of 3 doses or a ... A 2018 systematic review recommended the use of norfloxacin as it has the lowest rate of side effects with a comparable ... If intravenous therapy is chosen, single daily dosing with aminoglycosides is safe and effective. Fosfomycin can be used as an ... it is useful to initiate treatment with a single intravenous dose of a long-acting antibiotic such as ceftriaxone or an ...
Doses in excess of 1500 mg/kg orally and 250 mg/kg IV produced significant mortality in rodents. In the event of an acute ... which was a broader-spectrum conformationally locked analog of norfloxacin; both ofloxacin and levofloxaxin were synthesized ... More research is needed to determine the best dose and length of treatment. Overdosing experiments in animals showed loss of ... The use of non-steroidal anti-inflammatory drugs (NSAIDs) in combination with high dose fluoroquinolone therapy may lead to ...
In Japan, two fixed dose combinations are available: Loxonin S Plus, with magnesium oxide, and Loxonin S Premium, with apronal ... should not be administered at the same time as second-generation quinolone antibiotics such as ciprofloxacin and norfloxacin, ...
Doses equivalent to 50 and 10 times the recommended maximum human dose of ofloxacin (based on mg/kg) were fetotoxic (i.e., ... Ofloxacin is a second-generation fluoroquinolone, being a broader-spectrum analog of norfloxacin, and was synthesized and ... "After multiple-dose administration of 200 mg and 300 mg doses, peak serum levels of 2.2 and 3.6 μg/ml, respectively, are ... Additional studies in rats with oral doses up to 360 mg/kg/day (five times the recommended maximum human dose based on mg/m2 or ...
Pharmacokinetics of newer fluoroquinolones following a single oral dose Drug. Dosagea. (mg). BA (%). Cmax. (μg/mL). tmax. ( ... norfloxacin , ofloxacin, levofloxacin, trovafloxacin, gatifloxacin, moxifloxacin. ...
"Zanaflex (tizanidine hydrochloride) dose, indications, adverse effects, interactions... from PDR.net". www.pdr.net. Retrieved ... or norfloxacin; blood pressure medications such as clonidine, guanabenz, guanfacine (Tenex), or methyldopa; heart rhythm ...
"Dose-dependent rate of nosocomial pulmonary infection in mechanically ventilated patients with brain oedema receiving ... "Effect of ionic strength on the stability of norfloxacin". Pharmazie. 43 (2): 134. PMID 3393584. AlphaV-beta3-Integrin ... "Mutagenicity of radiations at low doses". Hereditas. 91 (1): 111-5. doi:10.1111/j.1601-5223.1979.tb01649.x. PMID 387673. "The ...
Approximately 60% of an orally administered dose is excreted in the urine as unchanged drug within 24 hours. A small amount of ... ofloxacin and norfloxacin on theophylline disposition in humans". Eur. J. Clin. Pharmacol. 35 (2): 161-5. doi:10.1007/ ... Backhouse CI, Matthews JA (June 1989). "Single-dose enoxacin compared with 3-day treatment for urinary tract infection". ... compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim". Antimicrob. Agents Chemother. 24 (5 ...
Ophthalmic drug administration
Ciprofloxacin and norfloxacin are drugs that are normally used to treat bacterial infections of the eye. It is of utmost ... increasing the frequency of dosing used for topicals. This is one of the fundamental problem associated with using topicals to ... has shown that when using the molecular imprinting method for loading drugs such as ketotifen and norfloxacin into the contact ... Some drugs that have been successfully loaded via this method are: timolol, norfloxacin, ketotifen, polyvinlypyrrolidone, and ...
Treated with a normal dose of the enantiomeric mixture, these persons will experience blood levels five-times higher than those ... Lexinor (norfloxacin). *Merrem/Meronem (meropenem). *Paludrine (proguanil). *Savarine(proguanil/chloroquine). *Synagis ( ... While omeprazole is approved only at doses of up to 20 mg for the treatment of gastroesophageal reflux, esomeprazole is ... approved for doses up to 40 mg. In 2007, Marcia Angell, former editor-in-chief of the New England Journal of Medicine and a ...
Treated with a normal dose of the enantiomeric mixture, these persons will experience blood levels five-times higher than those ... Lexinor (norfloxacin). *Merrem/Meronem (meropenem). *Paludrine (proguanil). *Savarine(proguanil/chloroquine). *Synagis ( ... While omeprazole is approved only at doses of up to 20 mg for the treatment of gastroesophageal reflux, esomeprazole is ... pure S-omeprazole treatment would give higher dose efficiency and less variation between individuals. In March 2001, the ...
Hosomi J, Maeda A, Oomori Y, Irikura T, Yokota T (1988). "Mutagenicity of Norfloxacin and AM-833 in Bacteria and Mammalian ... It is eliminated within 168 hours post-dosing. However, studies concerning the calf liver showed additional unidentified ... residues, of which a new metabolite, ml, represented the major single metabolite 24 hours after the last dose and at all ...
Additionally, studies have shown when treated with etoposide derivatives there is an anti-leukemic dose response that differ ... The first member of the fluoroquinolone subclass, norfloxacin, was discovered by Koga and colleagues at the pharmaceutical ... Quinolones can be divided into four generations: First generation: nalidixic acid Second generation: cinoxacin, norfloxacin, ... However, with the selective dosage, etoposide treatment is dose limiting proposing toxic effects like myelosupression ( ...
... as a selectable marker can grow in presence of high dose of triclosan in growth media. In surgery, triclosan coated sutures ... had increased resistance against antibiotics tetracycline and norfloxacin when exposed to triclosan. Results from a study ...
"Effects of moderate-dose versus high-dose trimethoprim on serum creatinine and creatinine clearance and adverse reactions". ...
Following an oral loading dose of 400 mg followed by 200 mg daily, mean concentrations of sparfloxacin (2.5 to 5 h after dosing ... The mean sparfloxacin concentration in maxillary sinus mucosa, 2-5 h after a single 400 mg dose, is 5.8 µg/g. ... Following a single 400 mg oral dose of sparfloxacin, the mean peak concentration in cantharides-induced inflammatory fluid is ... Following single oral doses of 100 or 200 mg, concentrations in skin of 0.56 and 0.82-1.31 lA-g per g, respectively, can be ...
In Russia as of 2016 a similar dose costs 231.25 RUB (approximately 4 USD). ...
2010s Haiti cholera outbreak
... the Haitian Ministry of Public Health and Population requested and received 1 million doses of the oral cholera vaccine, ... Fluoroquinolones: norfloxacin. Outbreaks. *Cholera pandemics: 1817-1824 cholera pandemic. *1826-1837 cholera pandemic ...
About 100 million bacteria must typically be ingested to cause cholera in a normal healthy adult. This dose, however, is ... The Zambian Ministry of Health implemented a reactive one-dose Oral Cholera Vaccine (OCV) campaign in April 2016 in three ... Fluoroquinolones: norfloxacin. Outbreaks. *Cholera pandemics: 1817-1824 cholera pandemic. *1826-1837 cholera pandemic ... that is effective as a single dose. ...
Pharmacokinetics of newer fluoroquinolones following a single oral dose Drug. Dosagea. (mg). BA (%). Cmax. (μg/mL). tmax. ( ... norfloxacin , ofloxacin, levofloxacin, trovafloxacin, gatifloxacin, moxifloxacin. ...
Norfloxacin Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Find patient medical information for Norfloxacin Oral on WebMD including its uses, side effects and safety, interactions, ... Missed Dose. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose ... How to use Norfloxacin Tablet. Read the Medication Guide provided by your pharmacist before you start taking norfloxacin and ... Take your next dose at the regular time. Do not double the dose to catch up. ...
Norfloxacin Dose For Uti - Norfloxacin 400 Mg Indications
Norfloxacin dose for uti: to cry out loudly against the unnatural mother who does not want to nurse her. norfloxacin 400 mg and ... Norfloxacin dose for uti: to cry out loudly against the unnatural mother who does not want to nurse her. norfloxacin 400 mg and ... norfloxacin and tinidazole tablets uses. '"'""' ''""■•'^''^ r-"'''^^- & ...
Norfloxacin Dose For Urinary Tract Infection - Noroxin Dosage For Pneumonia - Made in India
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Noroxin (Norfloxacin): Side Effects, Interactions, Warning, Dosage & Uses
Norfloxacin) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related ... Norfloxacin did not adversely affect the fertility of male and female mice at oral doses up to 30 times2 the usual human dose ( ... The oral administration of single doses of norfloxacin, 6 times2 the recommended human clinical dose (on a mg/kg basis), caused ... Unit Dose. Frequency. Duration. Daily Dose. Urinary Tract. Uncomplicated UTIs (cystitis) due to E. coli, K. pneumoniae, or P. ...
Norfloxacin ophthalmic Patient Assistance Program
Missed Dose. If you miss a dose, use it as soon as remembered; do not use it if it is near the time for the next dose, instead ... skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up. ... Since small amounts of norfloxacin are found in breast milk, consult your doctor before breast-feeding. ...
Noroxin 400 mg in Gijón ✜ Norfloxacin normal dose
Norfloxacin is given to treat urinary tract infections, such as cystitis and chronic prostatitis. Learn more about the ... Active Ingredients: Norfloxacin. Visit Pharmacy. Release form: pill Pack: 30 Function: Antibiotics Shipping around the world ... How to store norfloxacin Keep all medicines out of the reach and sight of children. Store in a cool, dry place, away from ... Data and doses, where given usually refer to adults as there are few data for children and neonates. Another set of guidelines ...
Degradation of norfloxacin in aqueous solution with UV/peroxydisulfate | Water Science and Technology | IWA Publishing
Effect of PDS dose. Listen The initial PDS dose is an important parameter in evaluating the practicability of UV/PDS technology ... Degradation of norfloxacin in aqueous solution with UV/peroxydisulfate Honghai Xue; Honghai Xue ... Figure 1 depicts that adding PDS efficiently accelerated the removal of NOR; the higher the dose of PDS, the faster the NOR ... Honghai Xue, Siyu Gao, Na Zheng, Ming Li, Xue Wen, Xindong Wei; Degradation of norfloxacin in aqueous solution with UV/ ...
Norfloxacin (Into the eye) | Drug Notes | Health Information | St. Luke's Hospital
If a dose is missed:. *If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for ... Norfloxacin (Into the eye). Norfloxacin (nor-FLOX-a-sin). Treats eye infections. This medicine is a quinolone antibiotic.. ... Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not ... You should not use this medicine if you have had an allergic reaction to norfloxacin or similar medicines (such as Ciloxan®, ...
Rifaximin Versus Norfloxacin in Spontaneous Bacterial Peritonitis - Full Text View - ClinicalTrials.gov
The Treatment arm will undergo rifaximin 1200 mg/day in 3 doses. ... Norfloxacin 400 mg/day in one dose. Drug: Norfloxacin ... Rifaximin Versus Norfloxacin in Spontaneous Bacterial Peritonitis. The safety and scientific validity of this study is the ... Rifaximin Versus Norfloxacin in the Primary Prophylaxis of Spontaneous Bacterial Peritonitis. Actual Study Start Date :. ... Norfloxacin. Anti-Bacterial Agents. Anti-Infective Agents. Gastrointestinal Agents. Topoisomerase II Inhibitors. Topoisomerase ...
Recurrent Urinary Tract Infections in Women: Diagnosis and Management - - American Family Physician
Buy Urodol 'Norfloxacin' Online Without Prescriptions. No Prescription Needed. Only $0.43. Order Urodol 'Norfloxacin' Online...
If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses ... Do not miss any dose. If you miss a dose of Noroxin, take it as soon as possible. ... Co norfloxacin, Constilax, Danilon, Diperflox, Effectsal, Epinor, Esclebin, Espeden, Firin, Flobarl, Flocidal, Flossac, Flox, ... Pharex norfloxacin, Pistofil, Quinabic, Renor, Renoxacin, Respexil, Rexacin, Ritromine, Sebercim, Senro, Setanol, Shinun, ...
Banned Fixed Dose Drug Combinations in India as of March 2016
Norfloxacin + Metronidazole + Zinc Acetate. 144. Zinc Carnosine + Oxetacaine. 145. Oxetacaine + Magaldrate + Famotidine. 146. ... Banned Fixed Dose Drug Combinations in India as of March 2016. The Central Drugs Standard Control Organization (CDSCO) in India ... Metronidazole + Norfloxacin. 73. Amoxicillin + Bromhexine 74. Ciprofloxacin + Fluticasone + Clotrimazole + Neomycin. 75. ... has banned the manufacture and sale of more than 300 fixed dose drug combination to prevent the misuse of drugs and to prevent ...
Ropinirole tablets - AHealthyMe - Blue Cross Blue Shield of Massachusetts
Noroxin Dosage Guide - Drugs.com
At this dosage, the urinary concentration exceeds the MICs for most urinary pathogens susceptible to norfloxacin, even when the ... Includes dose adjustments, warnings and precautions. ... The recommended daily dose of NOROXIN is as described in the ... should not be taken within 2 hours of administration of norfloxacin. Tablets NOROXIN should be taken with a glass of water. ...
Antibiotic treatment enhances the genome-wide mutation rate of target cells | PNAS
The norfloxacin doses applied (0, 12.5, 25, 37.5, 50, 62.5, 75, and 87.5 ng/mL) are orders of magnitude lower than peak ... 1983) Norfloxacin disposition after sequentially increasing oral doses. Antimicrob Agents Chemother 23(2):284-288. ... Comparisons of mutation rate responses to norfloxacin doses in wild-type lines with those of MMR− and DNA oxidative-damage ... A) Mutation rates of wild-type lines treated with different doses of norfloxacin. Regression of the mutation rate at fourfold ...
Fluoroquinolones | SpringerLink
Norfloxacin disposition after sequentially increasing oral doses. Antimicrob Agents Chemother 1983;23:284-8.PubMedGoogle ... Corrado ML, Strubble WE, Peter C, Hoogland V, Sabbaj J. Norfloxacin: Review of safety studies. Am J Med 1987;82(Suppl B):22-6. ... Patoia L, Guerciolini R, Menichetti F, Bucaneve G, Del Favero A. Norfloxacin and neutropenia. Ann Intern Med 1987;107:788-9. ...
Oral Urinary Tract Infection Treatments - Renal and Urology News
The chart includes the dosing and duration of therapy for each antibiotic. ... 750mg dose: 5 days. norfloxacin. Noroxin. tabs. 400mg. Uncomplicated UTI: 400mg every 12hrs. 3 days (E. coli, K. pneumoniae, or ... Max 1 dose/episode.. 1 dose. trimethoprim. -. tabs. 100mg, 200mg. Uncomplicated UTI: 100mg twice daily, or 200mg once daily. 10 ... Uncomplicated UTI: 1−2g once daily or in 2 divided doses Complicated UTI: 2g/day in 2 divided doses. ...
Propranolol 80 mg, 40 mg, 20 mg. Trusted Propranolol
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Comparison in the Treatment of Acute Cystitis Using Cephalosporin and Norfloxacin (CECI) - Full Text View - ClinicalTrials.gov
Chronic use of corticosteroids in a dose ≥ 5 mg/day of prednisone for over 30 days ... 130 research subjects on norfloxacin (test) 400 mg twice daily. Drug: Norfloxacin Norfloxacin Pills, 400 mg twice daily. ... Norfloxacin. Anti-Bacterial Agents. Anti-Infective Agents. Topoisomerase II Inhibitors. Topoisomerase Inhibitors. Enzyme ... Comparison in the Treatment of Acute Cystitis Using Cephalosporin and Norfloxacin (CECI) (CECI). This study has been withdrawn ...
1989 Sexually Transmitted Diseases Treatment Guidelines
The dose is 100,000 units/kg divided by ay given in 2 equal doses (4 equal doses per day for infants more than 1 week old). The ... Quinolones, such as ciprofloxacin and norfloxacin, are contraindicated during pregnancy and in children 16 years of age or ... may be utilized in appropriate doses. Recommended Regimen B Clindamycin IV 900 mg every 8 hours plus Gentamicin loading dose IV ... Some authorities prefer a dose of 125 mg ceftriaxone IM because it is less expensive and can be given in a volume of only 0.5 ...
Urekolin (Norfloxacin) Grunenthal
Meningitis | Lab Manual | Antimicrobial Susceptibility Testing | CDC
If the diameter around the disk of norfloxacin (5 ug) is less than 10 mm and/or if the MIC is , 16 µg/ml, there is a high risk ... 10The breakpoints for levofloxacin relate to high dose therapy.. 11Inducible clindamycin resistance can be detected only in the ... 9The norfloxacin disk diffusion test can be used to screen for fluoroquinolone resistance. Isolates categorized as susceptible ... 1Rx: Use of penicillin in meningitis requires therapy with maximum doses of intravenous penicillin (e.g., at least 3 million ...
Basaglar - Uses, Side Effects, Interactions - MedBroadcast.com
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Drug Delivery Letters, Volume 6 - Number 2
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- 0. Alters structure of bacterial DNA gyrase, thus promoting double-stranded DNA breakage, interfering with synthesis of bacterial protein and blocking bacterial survival Purchase Norfloxacin from BuyOvertheCounterUK. (underthemeso.com)
- In 1993, CDC recommended single-dose, oral therapy with ciprofloxacin (500 mg) or ofloxacin (400 mg) as two of the primary regimens for the treatment of uncomplicated gonorrhea (2) . (cdc.gov)
- The failure of infections to respond to single-dose therapy with 500 mg ciprofloxacin or 400 mg ofloxacin has been reported in the United Kingdom, Australia, Canada, Hong Kong, and the United States ( 3 - 7 , 12 ). (cdc.gov)
- Most members of the class including ciprofloxacin, enoxacin, ofloxacin, and norfloxacin have been implicated. (tga.gov.au)
- Quinolone antibiotics (including norfloxacin ) may cause serious and possibly permanent tendon damage (such as tendonitis , tendon rupture), nerve problems in the arms and legs ( peripheral neuropathy ), and nervous system problems. (webmd.com)
- Norfloxacin belongs to a group of antibiotics called fluoroquinolones, which work by killing the bacteria that cause the infections. (rxwiki.com)
- The death is out of your use in gonorrhea cipro dose specifically a coadministered antibiotics, but the patients can linger on for it' trials and not first show up for neuromuscular drugs, in some legs. (pizzalaprovencale.com)
- Tremors producing precautions of c. whether you sign up for the unfair muscle or choose to stop by for a home, gonorrhea cipro dose we offer antibiotics for symptoms and anesthetics. (pizzalaprovencale.com)
- You should not use this medication if you have ever had swelling or tearing of a tendon caused by taking norfloxacin or similar antibiotics. (medypharma.com)
- Finally, since antibiotic therapy is the third cornerstone of treatment, it is important to consider the appropriate selection, dosing, and duration of antibiotics. (uspharmacist.com)
- But what about nonlethal doses of antibiotics, the researchers wondered. (ubc.ca)
- To find out, the group treated Escherichia coli bacteria with low levels of the antibiotics norfloxacin, ampicillin, and kanamycin. (ubc.ca)
- In otherwise healthy women with uncomplicated infections, a single-dose or 3-day course of antibiotics is sufficient and associated with far fewer side effects and lower costs than longer courses of treatment. (healthcentral.com)
- Levaquin belongs to a group of medications known as fluoroquinolones or Quinolone Antibiotics (opens in new page), sometimes known just as "quinolones" for short, that also includes the antibiotics Cipro, Ciprofloxacin, Levofloxacin, Norfloxacin, and Avelox. (tendonitisexpert.com)
- Norfloxacin, sold under the brand name Noroxin among others, is an antibiotic that belongs to the class of fluoroquinolone antibiotics. (wikipedia.org)
- Who should not take Norfloxacin Tablet? (webmd.com)
- What conditions does Norfloxacin Tablet treat? (webmd.com)
- The half tablet dose was too much for me. (cnn.com)
- Take Norfloxacin 400 MG Tablet one hour before or two hours after the food. (medypharma.com)
- Do not stop taking Norfloxacin 400 MG Tablet before completion of course. (medypharma.com)
- Tendinitis and tendon rupture - Use of Norfloxacin 400 MG Tablet will increase the risk to develop tendinitis or tendon rupture during the treatment or several months after treatment. (medypharma.com)
- Drug-resistance - Usage of Norfloxacin 400 MG Tablet without sufficient proof or suspicion of a bacterial infection should be avoided. (medypharma.com)
- Pediatric use - The safety and effectiveness of Norfloxacin 400 MG Tablet have not been established in children and adolescents less than 18 years of age. (medypharma.com)
- Wonderfull great site http://www.marcata.net/walkmen/ albendazole 400 mg tablet If a DUR override is being submitted, an entry in Field 441-E6, DUR Outcome Code, is.norfloxacin and metronidazole syrup metronidazole 500mg tablets in philippines. (2p2e.tk)
- Each tablet contains: Norfloxacin 400 mg. (mims.com)
- Selective intestinal decontamination with norfloxacin, a quinolone with relatively poor gastrointestinal absorption and with antibacterial activity against GNB, is the most commonly used regimen, but several concerns have been recently raised in this regard. (clinicaltrials.gov)
- There are three contraindications found within the 2008 package insert: "Noroxin (norfloxacin) is contraindicated in persons with a history of hypersensitivity, tendinitis, or tendon rupture associated with the use of norfloxacin or any member of the quinolone group of antimicrobial agents. (wikipedia.org)
- Patients hypersensitive to Norfloxacin or quinolone compound. (mims.com)
- Oral multivitamin and mineral supplements containing divalent or trivalent cations such as iron or zinc may interfere with oral absorption of norfloxacin resulting in decreased serum and urine concentrations of the quinolone. (mims.com)
- NORFLOXACIN is a quinolone antibiotic. (mydiscountpill.com)
- Norfloxacin fights bacteria in the body After considering the citizen petition and reviewing Agency records and based on the information we have at this time, FDA has determined under § 314. (underthemeso.com)
- Norfloxacin fights bacteria in the body NOROXIN is available in 400-mg tablets. (underthemeso.com)
- Norfloxacin works by killing some types of bacteria that can cause these infections. (medbroadcast.com)
- Norfloxacin fights bacteria in the body. (medypharma.com)
- Ideally a doctor will test and identify what bacteria seem to be the problem and pick the best antibiotic, instead of just seeing an infection and Levaquin dosing and hoping that that will do the job. (tendonitisexpert.com)
- In ophthalmology, Norfloxacin licensed use is limited to the treatment of conjunctival infections caused by susceptible bacteria. (wikipedia.org)
- Norfloxacin, a fluoroquinolone, is 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. (rxlist.com)
- Norfloxacin, a fluoroquinolone, differs from non-fluorinated quinolones by having a fluorine atom at the 6 position and a piperazine moiety at the 7 position. (rxlist.com)
- In this study, the degradation kinetics and mechanisms of norfloxacin (NOR), a typical fluoroquinolone pharmaceutical, by the UV/peroxydisulfate (PDS) was investigated. (iwaponline.com)
- With hundreds of Escherichia coli cell lines evolving in a near-neutral scenario under exposure to the fluoroquinolone norfloxacin, this study reveals a significant linear relationship between the mutation rate and antibiotic concentration, while also demonstrating that antibiotic treatment compromises the efficiency of DNA oxidative-damage repair and postreplicative mismatch repair. (pnas.org)
- 161 that NOROXIN (norfloxacin) tablets, 400 mg, was not withdrawn for reasons of safety or effectiveness Jan 07, 2014 · Norfloxacin is a first generation fluoroquinolone that is typically used to treated urinary tract infections and prostatitis. (underthemeso.com)
- and these suggested doses are not a substitute for clinical judgment Noroxin (norfloxacin) is a fluoroquinolone antibiotic used to treat bacterial infections of the prostate and urinary tract. (underthemeso.com)
- JANACIN (Norfloxacin) is a fluoroquinolone derivative, which has a broad spectrum bactericidal activity. (mims.com)
- This study is to assess if the efficacy of cephalosporin is similar to the efficacy of norfloxacin in the acute cystitis treatment. (clinicaltrials.gov)
- For acute asthma exacerbations, the National Asthma Education and Prevention Program (NAEPP) Expert Panel recommends 4 to 8 puffs every 20 minutes for 3 doses, then 4 to 8 puffs every 1 to 4 hours as needed. (pdr.net)
- Taking into account the convenience of taking a single dose we conclude that fosfomycin trometamol is a reasonable alternative to 7 days nitrofurantoin 50 mg four times a day in the treatment of women with symptoms of acute uncomplicated urinary tract infections in general practice. (springer.com)
- Trimethoprim-sulfamethoxazole for acute dysuria in women: a single-dose or 10-day course. (springer.com)
- Gossius G, Vorland L. A randomised comparison of single-dose vs. three-day and ten-day therapy with trimethoprim-sulfamethoxazole for acute cystitis in women. (springer.com)
- These are poorly soluble insulin dose is particularly common cause acute form of a functional kidney. (musicaenlamochila.net)
- CHMP had concluded that the marketing authorizations for norfloxacin, when used in the treatment of acute or chronic complicated pyelonephritis, should be withdrawn because the benefits do not outweigh their risks in this indication. (wikipedia.org)
- If acute overdosage of norfloxacin occurs, the stomach should be emptied by inducing emesis or by gastric lavage. (mims.com)
Possible side effects of norfloxacin2
- This is one of the ABs that can be catabolic to gains if used at high doses for long periods of time, but it is generally not a problem. (anabolicminds.com)
- They have a tendency toward pseudomembranous colitis (severe diarrhea) when used at high doses for too long. (anabolicminds.com)
- Not teratogenic in animals but causes embryonic loss at high doses. (safefetus.com)
- At high doses, B1 selectivity can be lost and some B2 effects can be seen. (flashcardmachine.com)
- Antimicrobial agents used in high doses for short periods of time to treat gonorrhea may mask or delay the symptoms of incubating syphilis. (wikipedia.org)
- Crystalluria has occurred with high doses. (mims.com)
Spontaneous Bacterial P2
- Norfloxacin prevents spontaneous bacterial peritonitis recurrence in cirrhosis: results of a double-blind, placebo-controlled trial. (medscape.com)
- Norfloxacin is used for prevention of spontaneous bacterial peritonitis in cirrhotic patients who have a low ascites fluid protein level, impaired renal function, severe liver disease, have had a prior episode of spontaneous bacterial peritonitis, or esophageal variceal bleeding. (wikipedia.org)
- Norfloxacin is used to treat a variety of bacterial infections . (webmd.com)
- Therapy with norfloxacin at 400 mg orally twice per day for 7 days can reduce serious bacterial infection in patients with cirrhosis who have GI bleeding. (medscape.com)
- One study noted that the 37% incidence of serious bacterial infection was reduced to 10% when treatment with norfloxacin was instituted. (medscape.com)
- Norfloxacin prevents bacterial infection in cirrhotics with gastrointestinal hemorrhage. (medscape.com)
- Norfloxacin treats certain bacterial infections. (rxwiki.com)
- Norfloxacin is a prescription medication used to treat certain bacterial infections including urinary tract and prostate infections. (rxwiki.com)
- Norfloxacin is used to treat different bacterial infections of the prostate or urinary tract (bladder and kidneys). (medypharma.com)
- Using a simple procedure to estimate the number of mutations occurring in a cell culture, the team found that higher ROS levels led to higher mutation rates in the bacterial genomes-up to an eightfold rise in the case of norfloxacin. (ubc.ca)
- Norfloxacin Attar et a,l 1999 400 mg b.i.d. 10 GI surgery or intestinal stasis 30% Amoxicillin-clavulanic acid Attar et al 1999 500 mg t.i.d. 10 GI surgery or.Bacterial translocation in cirrhosis: consequences. (2p2e.tk)
- As noted above, under licensed use, norfloxacin is also now considered to be contraindicated for the treatment of certain sexually transmitted diseases by some experts due to bacterial resistance. (wikipedia.org)
- Norfloxacin inhibits DNA topoisomerase (ATP-hydrolyzing), a type II DNA topoisomerase commonly referred to as DNA-gyrase, in susceptible organisms, DNA-gyrase is necessary for bacterial DNA replication and some aspects of transcription, repair, recombination and transposition. (mims.com)
Allergic to norfloxacin1
- Do not take norfloxacin if you are allergic to norfloxacin, other quinolones (e.g., ciprofloxacin, nalidixic acid), or any other ingredients of the medication. (medbroadcast.com)
Absorption of norfloxacin1
- The simultaneous application of antacids containing aluminum hydroxide or magnesium hydroxide, drugs containing iron, zinc and sucralfate reduces the absorption of norfloxacin (the time interval between their appointment must be at least 2-4 hours). (jcenonline.com)
Treatment with norfloxacin1
- Participants 253 women with uncomplicated lower UTI were randomly assigned 1:1 to symptomatic treatment with the NSAID diclofenac (n=133) or antibiotic treatment with norfloxacin (n=120). (bmj.com)
Prophylaxis with norfloxacin3
- A 2012 guideline from the American Association for the Study of Liver Diseases recommends that adult cirrhotic patients who have survived an episode of SBP should receive long-term prophylaxis with norfloxacin or trimethoprim-sulfamethoxazole. (medscape.com)
- effects of prophylaxis with norfloxacin (400 mg/day) 0 10 20 30 40 50 60 70 4 8 12 16 20 Placebo Norfloxacin.NORFLOXACINA ABC Active Ingredient Norfloxacin 400 mg capasules - 14 capsules: VISIT ABC FARMACEUTICI GROUP WEB SITES: HOME: COMPANY PROFILE: PRODUCTS: ABC PARTNERS.Moduretic (moduretic tablets side effects). (2p2e.tk)
- Medscape The 2006 guidelines on the management of ascites in cirrhosis recommend prophylaxis with norfloxacin 400 mg.This happens because of xerotes cardizem 60 mg lowest price blood. (2p2e.tk)
Ciprofloxacin and Norfloxacin2
- Common norfloxacin side-effects What can I do if I experience this? (irse-itc.net)
- If the headaches continue, let your doctor know Feeling dizzy Do not drive and do not use tools or machines until you feel well again Rash If this is severe, let your doctor know Important: there are also a number of less common but more serious side-effects which have been associated with norfloxacin. (irse-itc.net)
- Common side effects of norfloxacin include dizziness, nausea, and diarrhea. (rxwiki.com)
- Norfloxacin can cause side effects that may be serious. (rxwiki.com)
- Norfloxacin and other medicines can affect each other causing side effects. (rxwiki.com)
- Your doctor also may need to change the doses of your medications or monitor you carefully for side effects. (medlineplus.gov)
- Patients often stop taking the higher dose because of its strong side effects such as vomiting. (cnn.com)
- Side-effects were reported at day 4 by 43% of the women receiving single-dose treatment, compared with 25% of the women in the seven-day treatment group, a significant difference. (springer.com)
- You'll notice that Norfloxacin side effects are the same as Levaquin side effects. (tendonitisexpert.com)
- Children A 1998 retrospective survey found that numerous side effects have been recorded in reference to the unapproved use of norfloxacin in the pediatric population. (wikipedia.org)
- If you have gonorrhea, prostatitis, or a urinary tract infection, your healthcare provider may prescribe norfloxacin. (emedtv.com)
- Single-dose therapy with trimethoprim-sulfa-methoxazole for urinary tract infection in women. (springer.com)
- Gossius G. Single-dose nitrofurantoin therapy for urinary tract infections in women. (springer.com)
- Single-dose antibiotic treatment for uncomplicated urinary tract infections. (springer.com)
- Single-dose antibiotic treatment for symptomatic urinary tract infections in women: a meta-analysis of randomized trials. (springer.com)
- Norfloxacin is generally well tolerated at dosage used in the treatment of urinary tract infections. (mims.com)
- Antibiotic treatment (norfloxacin). (clinicaltrials.gov)
- The European Medicines Agency, also in 2008, had recommended restricting the use of oral norfloxacin to treat urinary infections. (wikipedia.org)
- CHMP stated that doctors should not prescribe oral norfloxacin for complicated pyelonephritis and should consider switching patients already taking oral norfloxacin for this type of infection to an alternative antibiotic. (wikipedia.org)
- Antacids containing magnesium hydroxide or aluminum hydroxide may decrease absorption of oral norfloxacin. (mims.com)
- [ 18 ] In this study, Pande et al found over a 28-month period that 110 patients who were randomized to either norfloxacin 400 mg with probiotics or placebo did not have improved efficacy in primary or secondary prophylaxis or in reducing mortality in cirrhotic patients with ascites. (medscape.com)
- These data indicate that short-course therapy with either norfloxacin or TMP-SMX can be effectively used to treat shigellosis in adults in developing countries. (ajtmh.org)
- Fluoroquinolones including norfloxacin are considered contraindicated in pregnancy. (safefetus.com)
- Pregnancy Norfloxacin has been reported to rapidly cross the blood-placenta and blood-milk barrier, and is extensively distributed into the fetal tissues. (wikipedia.org)
- For this reason norfloxacin and other fluoroquinolones are contraindicated during pregnancy due to the risk of spontaneous abortions and birth defects. (wikipedia.org)
- As safer alternatives are generally available norfloxacin is contraindicated during pregnancy, especially during the first trimester. (wikipedia.org)
- The manufacturer only recommends use of norfloxacin during pregnancy when benefit outweighs risk. (wikipedia.org)
- During pregnancy, it is possible if the expected effect of therapy in the mother outweighs the potential risk to the fetus (adequate and strictly controlled studies of the safety of using norfloxacin in pregnant women have not been carried out, including for local use in the form of drops). (jcenonline.com)
- Norfloxacin should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus. (mims.com)
- In some countries, gonococcal infections have been treated with a single, orally administered dose of 250 mg ciprofloxacin (8) . (cdc.gov)
- Norfloxacin has been restricted in the Republic of Ireland due to the risks of C. difficile super infections and permanent nerve as well as tendon injuries. (wikipedia.org)
- Dr. James Lah, director of the cognitive neurology program at Emory University's Department of Neurology, regularly prescribes Aricept to patients, but doesn't prescribe the 23-milligram dose. (cnn.com)
- In patients with moderate renal impairment, the daily dose should be reduced. (mims.com)
- Women better than 40 years were significantly less first to be cured with either treatment psychosis and with single-dose therapy. (irse-itc.net)
- In this study the efficacy and tolerability of a single dose of 3 g fosfomycin trometamol and the conventional treatment with nitrofurantoin 50 mg four times daily for seven days were compared. (springer.com)
- Following oral administration of 800 mg single dose in healthy, fasting adults, peak serum concentration average 2.4 μg/ml. (mims.com)
- The recommended dose of norfloxacin for gonorrhea is 800 mg (two 400-mg tablets) as a single, one-time dose. (emedtv.com)
- Norfloxacin may be used to treat gonorrhea. (rxwiki.com)
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- Norfloxacin is also used to treat gonorrhea. (medypharma.com)
- Enoxacin (400 mg), lomefloxacin (400 mg), and norfloxacin (800 mg) were recommended among alternative regimens (2) . (cdc.gov)