Dose glycemic control insulin long acting. Medical search

Glucagon-like peptide-1 (GLP-1) is secreted from the gut after meals ( 1 ) and enhances glucose-induced insulin secretion, inhibits glucagon secretion, and delays the gastric-emptying rate ( 1 ). (diabetesjournals.org)
Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are a class of incretin peptides that enhances glucose-stimulated insulin secretion and reduces food intake ( 6 ). (sciencemag.org)
Type 1 diabetes results from an absolute deficiency of insulin secretion due to cellular-mediated autoimmune destruction of the pancreatic ®-cells. (diabetesjournals.org)
Type 2 diabetes results from insulin resistance and inadequate insulin secretion. (diabetesjournals.org)
Monogenic defects in ®-cells result in impaired insulin secretion with minimal or no defects in insulin action ( 1 ). (diabetesjournals.org)
Besides reducing insulin secretion, sulfonylureas may also act via additional mechanisms. (medindia.net)
1 As insulin resistance increases and insulin secretion declines, increasing doses of insulin may be required to maintain even near euglycemia. (dovepress.com)
Disposition index (DI) was calculated using the product of insulin sensitivity and insulin secretion. (bmj.com)
This trend is likely to continue as new formulations are developed to more closely mimic physiologic insulin secretion and to provide patients who have diabetes with more convenient options for integrating this therapy into their lifestyle. (jaoa.org)
In patients with established T2DM, insulin secretion is reduced because of progressive loss of pancreatic β-cell function. (jaoa.org)
Among these physiologic effects, GLP-1 stimulates glucose-dependent insulin secretion from pancreatic islet cells (attenuated in the presence of a low plasma glucose concentration), suppresses secretion of the glucose-raising hormone glucagon from pancreatic islet alpha cells, delays gastric emptying, and suppresses appetite through mechanisms that may include binding to GLP-1 receptors in the arcuate nucleus, paraventricular nucleus, and dorsomedial nucleus of the hypothalamus. (acc.org)
Precise coupling between changes in portal vein glucose concentration and insulin secretion permits exquisite minute-to-minute glycemic regulation. (todaysveterinarypractice.com)
Incretins act at specific receptors on the beta cell membrane to augment glucose-stimulated insulin secretion. (todaysveterinarypractice.com)
The expression of GPR119 on the pancreatic B cells and intestinal L cells provides a unique opportunity for a single drug to promote insulin and GLP-1 secretion. (hindawi.com)
In patients with T2DM, depletion of glucose-stimulated insulin secretion (GSIS) is a representative feature and leads to postprandial hyperglycemia, especially in the early phase, [ 3 ]. (hindawi.com)
GLP-1 analogs increase glucose-dependent insulin secretion through the gastrointestinal mechanism, which GLP-1 release in pancreatic b cell and enteroendocrine L cell activated GPR119 [ 5 ]. (hindawi.com)
We specifically compared the effects of HD0471953 with the dipeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin, which also increases GLP-1 level in blood stream [ 8 ], on glycemic control and insulin secretion in several animal models. (hindawi.com)
Although there have been improvements in insulin therapy since it was first conceived, it is still far from mimicking the physiological secretion of pancreatic β-cells, and research to find new insulin formulations and new routes of administration continues. (hkmj.org)
Correlation of destruction of the pancreas with diabetes was observed in 1890 by von Mering and Minkowski, 3 but internal secretion from the pancreas being responsible for control of sugar was not identified. (hkmj.org)
Youth with T2DM tend to be obese with evidence of insulin resistance in the setting of insufficient insulin secretion. (renalandurologynews.com)
In North America in 2004, many endocrinologists prefer the term "flexible insulin therapy" (FIT) to "intensive therapy" and use it to refer to any method of replacing insulin that attempts to mimic the pattern of small continuous basal insulin secretion of a working pancreas combined with larger insulin secretions at mealtimes. (wikipedia.org)
This insulin is referred to as basal insulin secretion, and constitutes almost half the insulin produced by the normal pancreas. (wikipedia.org)
The basal secretion of insulin during the fasting state plays an essential role in maintaining an appropriate level of endogenous glucose production, and the additional secretion of the hormone after a meal is critical for the anabolism and storage of this energy source. (springer.com)
Individuals with type 1 diabetes, in whom insulin secretion is greatly impaired, must therefore supplement their endogenous insulin by a basal-bolus administration of exogenous hormone in order to mimic the physiological regulation of energy metabolism and improve glycaemic control. (springer.com)
Genetic abnormalities of intracellular metabolic pathways or membrane cation transport have been found in 30-50% of cases, which cause constant insulin secretion through abnormally stimulated ATP-sensitive potassium channels and voltage gated Ca2+-channels of the pancreatic ß-cell (1,2). (bestbets.org)
Sulphonylureas play a pivotal role in glycaemic control by stimulating insulin secretion, thereby suppressing glucose production and stimulating the utilisation of glucose. (bmj.com)

Patients following the full basal-bolus treatment regimen received NovoLog ® (insulin aspart [rDNA origin] injection) before each meal, in addition to taking a basal insulin, for the entire trial. (prnewswire.com)
NovoLog ® (insulin aspart [rDNA origin] injection) should generally be given immediately (within 5-10 minutes) prior to the start of a meal. (prnewswire.com)
The U.S. Food and Drug Administration today approved Tresiba (insulin degludec injection) and Ryzodeg 70/30 (insulin degludec/insulin aspart injection) to improve blood sugar (glucose) control in adults with diabetes mellitus. (news-medical.net)
Ryzodeg 70/30 is a mixture of insulin degludec, a long-acting insulin analog, and insulin aspart, a rapid-acting human insulin analog. (news-medical.net)
Insulin aspart was administered before each meal in both treatment arms. (centerwatch.com)
Insulin degludec/aspart (IDegAsp) is the first soluble insulin co-formulation, combining a long-acting insulin degludec (IDeg) and rapid-acting insulin aspart (IAsp). (springer.com)
http://www.springerlink.com/content/6lktug1r2exurq0j/?p=af5e2f613a0f4c6690f8fdc920f48bd6π=5, (2007) Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with Type 1 diabetes, Journal Diabetologia, volume 47, number 4 / April, 2004. (wikipedia.org)
Two injections of biphasic insulin aspart (70/30, is more effective then glargine. (diabetesincontrol.com)
In patients with type 2 diabetes poorly controlled on oral antidiabetic drugs, the use of biphasic insulin aspart (70/30 BIAsp) appears to be more effective than long-acting insulin glargine in achieving glycemic control. (diabetesincontrol.com)
BIAsp 70/30 (NovoLog Mix 70/30, Novo Nordisk) contains 30% soluble insulin aspart and 70% insulin aspart crystallized with protamine, which is used to control both fasting and postprandial hyperglycemia, , and his colleagues point out. (diabetesincontrol.com)
Insulin aspart (Novolog) is human insulin in which the proline at position 28 is substituted with aspartic acid, also inhibiting self-aggregation. (diabetesjournals.org)
Pharmacodynamically, lispro and aspart bind as well to insulin receptors as does human insulin, but lispro has a slightly elevated affinity for the Insulin-like Growth Factor 1 (IGF-1) receptor (156 ± 16% for lispro vs. 81 ± 9% for aspart). (diabetesjournals.org)
The preprandial insulin is either rapid-acting (lispro, aspart, or glulisine) or short-acting (regular). (medscape.com)
Insulin aspart may also be used to treat diabetic ketoacidosis (DKA), though this is not an FDA-approved indication. (statpearls.com)
(statpearls.com)
Insulin aspart, or any rapid or short-acting insulin, is a mainstay of therapy in type-1 diabetes. (statpearls.com)
Total daily insulin doses are usually between 0.4 to 1 units/kg per day, divided into long-acting insulin and rapid-acting insulin, such as insulin aspart. (statpearls.com)
In type-2 diabetes, insulin aspart may be added for further glycemic control in addition to oral medications or long-acting insulin. (statpearls.com)
If A1c is less than 8%, consider reducing basal insulin dose when adding insulin aspart with meals. (statpearls.com)
Insulin aspart is also available commercially in a combination product with insulin degludec (long-acting insulin) or insulin aspart protamine (intermediate action insulin). (statpearls.com)
Insulin degludec plus insulin aspart is dosed once or twice a day with the main meal. (statpearls.com)
Insulin-naive patients should start insulin degludec/insulin aspart at 0.2 to 0.4 units/kg per day. (statpearls.com)
Insulin aspart/insulin aspart protamine is 30% insulin aspart, 70% insulin aspart protamine. (statpearls.com)
Insulin aspart regulates the metabolism of glucose. (statpearls.com)
Insulin aspart also inhibits gluconeogenesis (hepatic glucose production), lipolysis (breakdown of fat/lipids to fatty acids), and proteolysis (breakdown of proteins into amino acids). (statpearls.com)
Insulin aspart is equipotent to regular insulin with faster onset and shorter duration of action. (statpearls.com)
Thus insulin aspart is preferred for mealtime insulin coverage as it can be administered up to every 4 hours. (statpearls.com)
Insulin aspart should be administered subcutaneously (SC) within 5 to 10 minutes before a meal, with 1 to 4 meals per day. (statpearls.com)
Insulin aspart may also be administered using a continuous subcutaneous infusion through an insulin pump or intravenously (IV) as a diluted solution with close monitoring of blood glucose and serum potassium. (statpearls.com)
Insulin aspart may be mixed with NPH insulin only, but may only be administered SC once mixed. (statpearls.com)
Insulin aspart is contraindicated in patients with documented hypersensitivity to the drug or component of the formulation. (statpearls.com)
NovoRapid (Insulin aspart) is a modern insulin with a rapid-acting effect. (lynchspharmacy.com)
Similar glycaemic control with less nocturnal hypoglycaemia in a 38-week trial comparing the IDegAsp co-formulation with insulin glargine U100 and insulin aspart in basal insulin-treated subjects with type 2 diabetes mellitus. (bioportfolio.com)
To confirm non-inferiority of insulin degludec/insulin aspart (IDegAsp) once-daily (OD) versus insulin glargine (IGlar) U100 OD+insulin aspart (IAsp) OD for HbA after 26 weeks, and compare efficacy an. (bioportfolio.com)
Today's launch also furthers our continued efforts to serve patients through the availability of a full portfolio of short- and long-acting insulins, which also includes our insulin aspart that we expect to launch next year. (salesandmarketingnetwork.com)
citation needed] Rapid-acting insulin analogs such as lispro (brand name Humalog, made by Eli Lilly and Company) and aspart (brand name Novolog/Novorapid, made by Novo Nordisk and Apidra made by Sanofi Aventis) are preferred by many clinicians over older regular insulin for meal coverage and high correction. (wikipedia.org)

Basal and premixed insulin have been widely used for insulin therapy of type 2 diabetes mellitus (T2DM) in China. (frontiersin.org)
CHICAGO , June 24, 2013 /PRNewswire/ -- Patients with type 2 diabetes, who are inadequately controlled on basal insulin plus oral anti-diabetic medications (OADs), obtained comparable reduction in A1c, whether they intensified with bolus insulin treatment step by step, or followed a full basal-bolus treatment with every meal from the start. (prnewswire.com)
To assess the effects of PF-05231023 in humans, we conducted a placebo-controlled, multiple ascending-dose study in overweight/obese subjects with type 2 diabetes. (mendeley.com)
Can insulin dosing be reduced without compromising glycemic control in type 2 diabetes mellitus (DM)? (medscape.com)
The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes. (medscape.com)
OBJECTIVE There is a dearth of published literature comparing glucose variability (GV) between different insulin regimens in type 2 diabetes. (diabetesjournals.org)
This cohort study compares GV using continuous glucose monitoring (CGM) in patients with well-controlled type 2 diabetes using four common insulin regimens: basal insulin + oral drugs (BO), basal insulin + glucagon-like peptide 1 receptor agonist (GLP-1 RA) (BGLP), premixed insulin (PM), and basal-bolus insulin (BB). (diabetesjournals.org)
RESEARCH DESIGN AND METHODS Consecutive patients from three endocrinology clinics who met study criteria-type 2 diabetes, age 18 to 80 years, BMI ≤ 45 kg/m 2 , stable insulin regimen for a minimum of 6 months, and stable A1C value ≤7.5% (58 mmol/mol) before study enrollment-underwent 6-day masked CGM. (diabetesjournals.org)
The duration of type 2 diabetes and the degree of glycemic control are major risk factors for microvascular and macrovascular complications ( 1 ). (diabetesjournals.org)
The majority of intervention trials in type 2 diabetes to date have focused on A1C as the primary measure of glycemic control. (diabetesjournals.org)
3.9mmol/L) in individuals with type 1 diabetes treated with ultra-Long acting insulin degludec during aerobic exercise with or without prior ingestion of a single oral fructose load. (clinicaltrials.gov)
Glycaemic control remains complex and demanding during exercise for type 1 diabetes (T1D) patients. (clinicaltrials.gov)
Long-acting insulins play an essential role in the treatment of patients with type-1 diabetes and in patients with type-2 diabetes with advanced disease,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in the FDA's Center for Drug Evaluation and Research. (news-medical.net)
The efficacy and safety of Tresiba used in combination with mealtime insulin for the treatment of patients with type-1 diabetes were evaluated in two 26-week and one 52-week active-controlled clinical trials involving 1,102 participants exposed to Tresiba. (news-medical.net)
The efficacy and safety of Tresiba used in combination with mealtime insulin or used as add-on to common background oral antidiabetic drugs for the treatment of patients with type-2 diabetes were evaluated in four 26-week and two 52-week active-controlled clinical trials involving 2,702 participants exposed to Tresiba. (news-medical.net)
In participants with type 1 and 2 diabetes who had inadequate blood sugar control at trial entry, treatment with Tresiba provided reductions in HbA1c (hemoglobin A1c or glycosylated hemoglobin, a measure of blood sugar control) in line with reductions achieved with other, previously approved long-acting insulin. (news-medical.net)
The efficacy and safety of Ryzodeg 70/30 used in combination with mealtime insulin for the treatment of patients with type 1 diabetes were evaluated in one 26-week active controlled clinical trial involving 362 participants exposed to Ryzodeg 70/30. (news-medical.net)
The efficacy and safety of Ryzodeg 70/30 administered once or twice daily for the treatment of patients with type 2 diabetes were evaluated in four active controlled 26-week clinical trials involving 998 participants exposed to Ryzodeg 70/30. (news-medical.net)
In participants with type 1 and 2 diabetes who had inadequate blood sugar control at trial entry, treatment with Ryzodeg 70/30 provided reductions in HbA1c equivalent to reductions achieved with other, previously approved long-acting or pre-mixed insulin. (news-medical.net)
Adding insulin to oral therapy in type 2 diabetes is essential when glycemic control is suboptimal. (renalandurologynews.com)
However, most patients eventually lose control of diabetes and require insulin. (renalandurologynews.com)
All patients with type 2 diabetes who have not achieved goal A1c and who are on maximal oral hypoglycemics and/or incretin therapy should be started on insulin. (renalandurologynews.com)
The recommended starting dose of Tresiba in insulin naïve patients with type I diabetes is approximately one-third to one-half of the total daily insulin dose. (centerwatch.com)
As a general rule, 0.2 to 0.4 units of insulin per kilogram of body weight can be used to calculate the initial total daily insulin dose in insulin naïve patients with type I diabetes. (centerwatch.com)
The recommended starting dose of Tresiba in insulin naïve patients with type II diabetes mellitus is 10 units once daily. (centerwatch.com)
Type I and Type II Diabetes Mellitus: Start Tresiba at the same unit dose as the total daily long or intermediate-acting insulin unit dose. (centerwatch.com)
The efficacy of Tresiba was evaluated in a 52-week randomized, open-label, multicenter trial that enrolled 1030 insulin naïve patients with type 2 diabetes mellitus inadequately controlled on one or more oral antidiabetic agents (OADs). (centerwatch.com)
Symlin is specifically indicated for the mealtime treatment of Type I and Type II diabetes in combination with standard insulin therapy, in patients who have failed to achieve adequate glucose control on insulin monotherapy. (centerwatch.com)
Recommended dosing varies depending on whether a patient has Type I or Type II diabetes: for Type I patients, initial recommended dosing is 15 mcg, which should be titrated at 15 mcg increments to a maintenance dose of 30 mcg or 60 mcg as tolerated. (centerwatch.com)
The drug was also investigated for the treatment of Type I diabetes in a dose titration study. (centerwatch.com)
Symlin was investigated for the treatment of Type II diabetes in a pair of long-term randomized, double-blind, placebo-controlled studies. (centerwatch.com)
Blunted insulin-stimulated endothelial function may be a mechanism for the development of atherothrombotic disease in type 2 diabetes, but it is unknown whether hypoglycemic drug therapy can modulate this abnormality. (diabetesjournals.org)
We studied patients with type 2 diabetes and stable ischemic heart disease ( n = 28) and lean, healthy control subjects ( n = 31). (diabetesjournals.org)
Hyperglycemia ( 2 ) and insulin resistance ( 3 ) are the characteristics of type 2 diabetes most often attributed a causal relation with atherosclerosis. (diabetesjournals.org)
However, these effects are blunted in patients with obesity-associated insulin resistance or type 2 diabetes ( 10 , 11 , 12 ). (diabetesjournals.org)
Insulin glargine injection (Basaglar), a long-acting human insulin analog, for improving glycemic control in adults with type 1 or type 2 diabetes. (acpinternist.org)
A considerable proportion of people with Type 2 diabetes are missing or mistiming their long-acting insulin,' said lead researcher and health psychologist Meryl Brod of The Brod Group. (drugstorenews.com)
Furthermore, in patients with uncontrolled type 2 diabetes previously treated with insulins, IDegAsp twice daily effectively improves glycated hemoglobin and FPG, with fewer hypoglycemic episodes versus premix insulins and basal bolus therapy. (springer.com)
In patients with type 1 diabetes mellitus, IDegAsp once daily with two doses of IAsp is a convenient, yet effective, regimen as compared to the conventional 4-5 injection-based basal bolus therapy. (springer.com)
IDegAsp is an appropriate and reasonable option for initiation of insulin therapy in both type 1 and type 2 diabetes. (springer.com)
Such a scenario is all too common in diabetes patients receiving PN and who face the unique challenges of maintaining glycemic control for the long haul. (todaysdietitian.com)
Given the dire consequences of poor glycemic control in these patients, it's imperative for RDs to understand the complexities of diabetes and PN management. (todaysdietitian.com)
Diabetes patients whose blood sugar is controlled experience many benefits from PN, ranging from fluid maintenance to improved immune function. (todaysdietitian.com)
Efforts to make diabetes care more manageable, and easier on the patient, have led to the introduction of insulin "analogs" - medicines that act similarly to ordinary insulin, but which are supposed to provide additional benefits. (medindia.net)
Recent research from Generex Biotechnology, a company focused on advanced insulin delivery and diabetes vaccine research, shows that the advantages of insulin analogs may be illusory. (medindia.net)
The year-long study examined 26 subjects with type 1 diabetes, which is normally treated with "basal" injected injection once or twice a day to provide baseline glycemic control, and additional insulin injections before meals. (medindia.net)
People with diabetes, and physicians treating them, have become excited in recent years by insulin analogs due to their rapid window of action. (medindia.net)
PDF] Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes. (semanticscholar.org)
Long-Acting Release Formulation of Exendin-4 Based on Biomimetic Mineralization for Type 2 Diabetes Therapy. (semanticscholar.org)
DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes. (semanticscholar.org)
Day-long subcutaneous infusion of exenatide lowers glycemia in patients with type 2 diabetes. (semanticscholar.org)
There is relatively little data from China on the efficacy and safety of adding prandial insulin to basal insulin plus oral antidiabetic drugs (OADs) in people with poorly controlled type 2 diabetes mellitus (T2DM). (springer.com)
Type 2 diabetes (T2D) accounts for most cases and is characterized by a state of insulin resistance and impaired ability to maintain glucose homeostasis. (sciencemag.org)
IN BRIEF Six million people with diabetes use insulin either alone or in combination with an oral medication. (diabetesjournals.org)
The management of diabetes occurs via nonpharmacological interventions, typically in conjunction with either monotherapy or a combination of insulin and oral medications. (diabetesjournals.org)
A 2012 survey examining the number of patients who use diabetes medications found that 2.9 million people with diabetes (14%) use insulin only, 3.1 million (14.7%) use a combination of insulin and oral medications, 11.9 million (56.9%) use oral medications only, and 3 million (14.4%) do not use any medications to manage their diabetes ( 2 ). (diabetesjournals.org)
Increased all-cause mortality and hospitalization have been linked to nonadherence to insulin therapy in patients with diabetes ( 4 ). (diabetesjournals.org)
Achieving glycemic control has been associated with a reduction in microvascular complications in both type 1 and type 2 diabetes and a reduction in all-cause mortality in type 1 diabetes ( 7 ). (diabetesjournals.org)
Although pharmacotherapy may be one part of obtaining glycemic control, diabetes self-management education, medical nutrition therapy, education regarding physical activity, and psychosocial care are also key to managing diabetes ( 8 ). (diabetesjournals.org)
Although there are many treatment options for patients with type 2 diabetes, insulin is the most effective therapy to reduce glucose levels. (diabetesjournals.org)
Insulin treatment, first used in 1922, is always indicated in autoimmune type 1 diabetes. (diabetesjournals.org)
The recommended starting dose of Lantus ® in patients with type 2 diabetes who are not currently treated with insulin is 0.2 Units/kg or up to 10 Units once daily, adjusted to patient's appropriate FPG target. (lantus.com)
Two breakthrough studies in nonpregnant diabetic patients demonstrated the effectiveness of intensified therapy: the Diabetes Control and Complications Trial 3 , 4 in type 1 diabetes and the U.K. Prospective Diabetes Study in type 2 diabetes. (diabetesjournals.org)
New pharmacological agents, such as insulin analogs (mainly lispro) and oral antidiabetic drugs (mainly glyburide), have profoundly altered the management of diabetes in pregnancy, producing outcomes comparable to those among the general population. (diabetesjournals.org)
Early and Aggressive Initiation of Insulin Therapy for Type 2 Diabetes: What Is the Evidence? (diabetesjournals.org)
Type 2 diabetes is a progressive disease in which b[beta symbol]-cell function continually declines and eventually fails, ultimately requiring nearly all patients to be placed on insulin therapy. (diabetesjournals.org)
4 - 7 However, type 2 diabetes is a progressive disease, and the need for increasing the intensity of treatment to maintain glycemic control is an indicator of that progression. (diabetesjournals.org)
13 , 15 , 16 Thus, glycemic control is the primary therapeutic goal in the management of type 2 diabetes. (diabetesjournals.org)
Diabetes In Control. (diabetesincontrol.com)
The introduction of new insulin analogs over the past few years should help primary practitioners and their patients with diabetes achieve physiological insulin replacement and near-normal glucose levels. (diabetesjournals.org)
This article reviews currently available insulins and replacement of insulin in a physiological manner for patients with type 1 or type 2 diabetes and provides examples of patients for whom insulin dosages changed over time. (diabetesjournals.org)
5 , 6 Education about insulin physiology and the use of insulin in patients with diabetes should enable primary care providers to come closer to physiological insulin replacement and return glucose levels to near-normal concentrations. (diabetesjournals.org)
Insulin use in diabetes is an integral component of the management of about 30-40% of the 10.3 million Americans diagnosed as having diabetes. (diabetesjournals.org)
7 This review is designed to help health care practitioners become familiar with the different types of insulin that are now available and how each should be used to optimize treatment for the large population of patients with diabetes. (diabetesjournals.org)
It has an onset of action 15-60 min after injection, a peak effect 2-4 h after injection, and a duration of action of ranging from 5 to 8 h. 14 For best results, the slow onset of regular insulin requires it to be administered 30-60 min before meals, which is certainly not a convenient way for busy or hungry people with diabetes to prepare for meals. (diabetesjournals.org)
However, the slow onset of action does not hold true for intravenous administration, making regular insulin appropriate for intravenous treatment of diabetes. (diabetesjournals.org)
Insulin resistance has been proposed as one of the causes of poor glycemic control in youth with type 1 diabetes who have excess weight or obesity. (diabetesincontrol.com)
Youth with type 1 diabetes (T1D) who have excess weight or obesity often have suboptimal glycemic control. (diabetesincontrol.com)
Randomized controlled trials with metformin in adolescents with type 2 diabetes (T2D) reported a decrease in fasting plasma glucose concentration [ 3 ]. (diabetesincontrol.com)
Glyset ® (miglitol) is indicated as monotherapy as an adjunct to diet and exercise to lower blood glucose in patients with type 2 diabetes whose hyperglycemia cannot be controlled by diet and exercise alone. (ndei.org)
effectiveness of insulin degludec versus insulin The outcome measure was the incremental cost- glargine U100 in patients with type 1 and type 2 effectiveness ratio (ICER) or cost per quality- diabetes mellitus in Serbia. (deepdyve.com)
Diabetes is a chronic metabolic dis- riers to insulin therapy include fear and risk of order characterised by high blood sugar levels hypoglycaemia, weight gain and restrictive (hyperglycaemia) and is a leading cause of treatment regimens [11, (deepdyve.com)
Oral hypoglycemic drugs or oral diabetic medications or diabetes pills are of several types drugs in each group act in a different way to bring about blood glucose control. (medindia.net)
Prevention of weight gain when starting insulin therapy in patients with type 2 diabetes. (trialregister.nl)
Prevention of insulin induced weight gain in type 2 diabetes: Cognitive behavioural therapy versus Liraglutide. (trialregister.nl)
Most people with type 2 diabetes on maximum oral glucose lowering drugs need insulin therapy to improve glycaemic control. (trialregister.nl)
In our study we compare the preventive effects on insulin induced weight gain of two different therapies that are associated with weight loss in patients with type 2 diabetes: Liraglutide and Cognitive Behavioral Therapy. (trialregister.nl)
To compare efficacy and safety of two fasting plasma glucose (FPG) titration targets [4.4-6.1 mmol/l (80-110 mg/dl) and 3.9-5.0 mmol/l (70-90 mg/dl)] using a patient-directed, treat-to-target algorithm for once-daily basal insulin in insulin-naïve subjects with type 2 diabetes suboptimally treated with oral antidiabetes drugs (OADs). (nih.gov)
(nih.gov)
Insulin therapy plays a critical role in the treatment of type 1 and type 2 diabetes mellitus. (dovepress.com)
The use of insulin is a mainstay of treatment for all individuals with type 1 diabetes mellitus (T1DM) and for many individuals with type 2 diabetes mellitus (T2DM). (dovepress.com)
The growing prevalence of type 2 diabetes (T2D), and factors such as increasing obesity, and greater life expectancy are driving the diabetes device market and creating greater opportunity for devices that automatically monitor blood glucose and deliver appropriate insulin doses. (endocrineweb.com)
A wearable and interactive blood glucose monitoring system-the Dexcom G6- is the first to gain Food and Drug Administration marketing approval for use with compatible diabetes management products, including insulin pumps and automatic dosing systems, and blood glucose meters. (endocrineweb.com)
Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
Most pediatric patients with diabetes have type 1 and a lifetime dependence on exogenous insulin. (medscape.com)
Blood glucose tests using capillary blood samples, reagent sticks, and blood glucose meters are the usual methods for monitoring day-to-day diabetes control. (medscape.com)
All children with type 1 diabetes mellitus require insulin therapy. (medscape.com)
Diabetes mellitus (DM) is a chronic metabolic disorder caused by an absolute or relative deficiency of insulin, an anabolic hormone. (medscape.com)
Type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus [NIDDM]) is a heterogeneous disorder. (medscape.com)
Most patients with type 2 diabetes mellitus have insulin resistance, and their beta cells lack the ability to overcome this resistance. (medscape.com)
dose of insulin glargine 100 U/mL in overweight or obese Chinese patients with type 2 diabetes: Results of a multicentre, open-label, randomized controlled trial (BEYOND VII). (tripdatabase.com)
All patients with type 1 diabetes should learn how to self-monitor and record their blood glucose levels with home analyzers and adjust their insulin doses accordingly. (medscape.com)
Patients with type 1 diabetes require lifelong insulin therapy. (medscape.com)
Type 2 diabetes mellitus is on the rise, yet glycemic control continues to elude patients-and their physicians. (jaoa.org)
The continued prevalence of the disorder, changes in prescribing patterns, and recent data indicating that only one third of patients with type 2 diabetes mellitus achieve glycemic control underscore the need for physicians to reevaluate the clinical management of this now common disorder. (jaoa.org)
Although potential barriers and complications to initiation exist, patients should understand that achieving and maintaining glycemic control reduces the risk of long-term complications as a result of type 2 diabetes mellitus. (jaoa.org)
1 Measurement of glycated hemoglobin A 1c (HbA 1c ) continues to be the criterion standard for evaluating glycemic control, 2 the ultimate goal of insulin therapy and a fundamental component of diabetes management. (jaoa.org)
3 The American Diabetes Association and the American Association of Clinical Endocrinologists (AACE) in conjunction with the American College of Endocrinology (ACE) have recently published recommendations for glycemic control, including goals for HbA 1c levels ( Table 1 ). (jaoa.org)
Insulin therapy has been the mainstay of therapy for patients with type 2 diabetes mellitus for the past 90 years. (jaoa.org)
When insulin replacement therapy was introduced more than 90 years ago, 2 it was a lifesaving option for patients with type 1 diabetes mellitus (T1DM), even though the formulations used were relatively crude. (jaoa.org)
Diabetes mellitus (DM) affects 7% of Americans, according to 2005 data from the Centers for Disease Control and Prevention. (racernm.com)
19 , 21 , 22 , 25 , 34 Physical exercise aids in diabetes remedy by improving glucose metabolism eight , 33 and insulin sensitivity, 36 and it can lessen the use of oral drugs and insulin. (racernm.com)
Although glycemic control is an essential component of treatment of type 2 diabetes, efforts to prevent macrovascular complications such as myocardial infarction, stroke, and peripheral vascular disease necessitate treatment of dyslipidemia, smoking cessation, blood pressure control, implementation of heart healthy dietary habits and regular physical activity, and possible treatment with aspirin and other medications. (acc.org)
Although there may be an expectation that treatments for hyperglycemia should also prevent macrovascular complications in type 2 diabetes, it is important to recognize that microvascular complications are most impacted by glycemic control, whereas macrovascular complications are most impacted by control of traditional cardiovascular risk factors. (acc.org)
PLAINSBORO, N.J., Jan. 26, 2016 -- (Healthcare Sales & Marketing Network) -- Novo Nordisk, a world leader in diabetes care, today announced the availability of its newest insulin, Tresiba (insulin degludec injection), a once-daily, long-acting basal insulin, at pharmacies nationwide. (salesandmarketingnetwork.com)
Adults with diabetes who require insulin therapy often must plan their schedules to accommodate the need to take insulin at the same time every day. (salesandmarketingnetwork.com)
With its long-acting blood glucose lowering effect, lasting for at least 42 hours, Tresiba is a shining example of that," said Camille Lee, senior vice president, diabetes Marketing, Novo Nordisk Inc. "We're proud to offer this new treatment for adults living with diabetes and are excited to see the impact it may have on management of their blood sugar. (salesandmarketingnetwork.com)
In type 1 diabetes (T1DM), a good metabolic control is important to reduce and/or postpone complications. (smw.ch)
The aims of this study were to determine the current level of metabolic control in T1DM patients on different treatment regimens, followed at the diabetes outpatient unit of the University Children's Hospital Bern, Switzerland, and to compare it with both the reported data from ten years ago (1998) and with the current guidelines of the ADA and ISPAD. (smw.ch)
Underlining these facts, the Diabetes Control and Complications Trial (DCCT) in 1993 followed by the Epidemiology of Diabetes Interventions and Complications (EDIC) study in 2003 unambiguously showed that improving glycaemic control in a population of 13-39 year old T1DM subjects reduced the risk for microvascular complications [4, (smw.ch)
A medically ill patient, on the other hand, will likely have a significantly impaired glucose tolerance that may change or revert to normal once no longer ill, thus follow-up monitoring and testing would be appropriate before the label of diabetes is given to a hospitalized inpatient. (clinicaladvisor.com)
Diabetes affects persons of all ages and races and arises from abnormalities of either decreased insulin production (Type 1) or decreased insulin sensitivity (Type 2). (clinicaladvisor.com)
Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia as a result of defects in insulin sensitivity [ 1 , 2 ]. (hindawi.com)
Documento de posicionamiento: evaluación y manejo de la hipoglucemia en el paciente con diabetes mellitus. (elsevier.es)
For most people with type 2 diabetes, achieving an HbA 1c between 7% and 8% will best balance long-term benefits with harms such as low blood sugar, medication burden, and costs," he added. (medscape.com)
But experts from the American Diabetes Association (ADA) and American Association of Clinical Endocrinologists (AACE) contacted by Medscape Medical News take issue with these higher glycemic control targets, which they argue don't consider, for example, the cardiovascular disease (CVD) benefits of newer therapies which often lower HbA 1c levels. (medscape.com)
These guidelines analyzed evidence from five large, long-term randomized trials of a "treat-to-target" strategy in type 2 diabetes: Action to Control Cardiovascular Risk in Diabetes (ACCORD), Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE), United Kingdom Prospective Diabetes Study (UKPDS) trials 33 and 34, and Veterans Affairs Diabetes Trial (VADT). (medscape.com)
In patients with type 1 diabetes, must use with a long-acting insulin. (scribd.com)
Multiple daily insulin injections have been a common regimen worldwide for the management of diabetes mellitus but involved potential safety and compliance problems. (sciencemag.org)
Optimal treatment of diabetes mellitus generally requires intensive insulin therapy to achieve effective glycemic control and to reduce late complications ( 1 ). (sciencemag.org)
An initial breakdown of 50% basal insulin, 50% rapid-acting insulin is a starting place for most patients with type-1 diabetes and adjusted based on blood glucose. (statpearls.com)
Type-2 diabetes patients often use more basal insulin than bolus insulin compared to type-1 diabetes patients. (statpearls.com)
Recommended starting doses for type-2 diabetes mellitus patients may be any of the following options: 4 units per meal, 0.1 units/kg per meal, or 10% of the basal dose. (statpearls.com)
We know there is a long-term trend in diabetes for diabetes growth over the next couple of years. (reachmd.com)
Pregnancy aggravates preexisting type 1 ( insulin -dependent) and type 2 (non- insulin -dependent) diabetes but does not appear to exacerbate diabetic retinopathy, nephropathy, or neuropathy ( 1 ). (merckmanuals.com)
Gestational diabetes (diabetes that begins during pregnancy [ 2 ]) can develop in overweight, hyperinsulinemic, insulin -resistant women or in thin, relatively insulin -deficient women. (merckmanuals.com)
Preconception counseling and optimal control of diabetes before, during, and after pregnancy minimize maternal and fetal risks, including congenital malformations. (merckmanuals.com)
Humalog ® is used to treat people with diabetes for the control of blood sugar. (humalog.com)
Humalog ® Mix75/25 ™ (75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog ® Mix50/50 ™ (50% insulin lispro protamine suspension and 50% insulin lispro injection) are used to treat adults with diabetes for the control of high blood sugar. (humalog.com)
Insulin is a key player in the control of hyperglycaemia for patients with type 1 diabetes mellitus and selected patients with type 2 diabetes mellitus. (hkmj.org)
Non-invasive delivery of insulin has long been a major goal for the treatment of diabetes mellitus. (hkmj.org)
This article reviews the emerging technologies, including insulin inhalers, insulin buccal spray, insulin pill, islet cell transplant, and stem cell therapy, as treatment options for diabetes mellitus. (hkmj.org)
2 Therapy with insulin is effective at lowering blood glucose in patients with diabetes. (hkmj.org)
hyperglycaemia in type 1 diabetes is a result of insulin deficiency and, in type 2 diabetes, it is due to both impaired tissue response to insulin and insulin deficiency. (hkmj.org)
The discovery of insulin has been hailed as one of the most dramatic events in the history of the treatment of diabetes. (hkmj.org)
Before the discovery of insulin, diabetes was a feared disease that led to death. (hkmj.org)
In patients with type 2 diabetes, the combination of insulin degludec and liraglutide in an injection pen has more disadvantages than advantages. (prescrire.org)
In patients with type 2 diabetes, when metformin does not provide satisfactory glycaemic control, there is no evidence that the combination of liraglutide with an insulin is of any benefit in preventing clinical complications of diabetes. (prescrire.org)
Insulin degludec + liraglutide (Xultophy°) in type 2 diabetes. (prescrire.org)
To summarize the available information on the use of insulin glargine (Trade Mark: Lantus) - a biosynthetic, long-acting human insulin analogue - to treat type 2 diabetes. (york.ac.uk)
Diabetes is a chronic condition that can present in two different ways type-1 insulin -dependent diabetes or the more common type-2 insulin non-dependent diabetes. (aspeneducationgroup.com)
Primary Objective: To compare LixiLan to insulin glargine in glycated hemoglobin (HbA1c) change from baseline to week 26 in patients with type 2 diabetes mellitus. (bioportfolio.com)
The purpose of this study is to test for superiority in improvements from baseline in patient reported outcomes in subjects with type 1 or type 2 diabetes when treated with insulin glargin. (bioportfolio.com)
A comparative effectiveness study of degludec and insulin glargine 300U/mL in insulin-naïve patients with type 2 diabetes. (bioportfolio.com)
To compare the real-world effectiveness of insulin degludec (degludec) and glargine 300 units/mL (glargine U300) in insulin-naïve adult patients with type 2 diabetes in routine US clinical practice. (bioportfolio.com)
In the DUAL (Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes) VII trial, IDegLira (a combination of insulin degludec and liraglutide) was compared with insulin glargine U100 plus in. (bioportfolio.com)
Weight loss in patients with type 2 diabetes (T2D) mellitus receiving once-weekly dulaglutide plus insulin lispro or insulin glargine plus insulin lispro: An AWARD-4 post-hoc analysis across baseline body mass index subgroups. (bioportfolio.com)
Effect of single dose of insulin glargine/lixisenatide fixed ratio combination (iGlarLixi) on postprandial glucodynamic response in Japanese patients with type 2 diabetes mellitus: A phase 1 randomized trial. (bioportfolio.com)
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). (bioportfolio.com)
Type II diabetes mellitus is no longer considered a disease exclusively found in adults. (bioportfolio.com)
However, because SGLT2 inhibitors have a mechanism of action that does not require the presence of endogenous insulin, these drugs should also be efficacious in type 1 diabetes where endogenous insulin production is greatly reduced or absent. (hindawi.com)
In addition, a reduction in glycemic variability has the potential to protect against the development of both the microvascular (retinopathy, nephropathy, and neuropathy) and the macrovascular (ischemic heart disease, peripheral vascular disease, and cerebrovascular disease) complications of type 1 diabetes [ 8 , 9 ]. (hindawi.com)
Unlike the other oral agents utilized in the treatment of diabetes SGLT2 inhibitors are not dependent upon the presence of endogenous insulin to be effective and because of this insulin-independent mode of action, the SGLT2 inhibitors have the potential to be effective in those type 1 diabetic patients who through resistance to the action of exogenous insulin have been unable to obtain adequate glycemic control. (hindawi.com)
In addition, many patients with type 1 diabetes through the achievement of excellent glycemic control will avoid microvascular complications but gain weight and develop insulin resistance and the metabolic syndrome which may increase the risk of macrovascular complications. (hindawi.com)
The paper points put that the 2015 National Diabetes Foot Care Audit found that many patients experienced long waits for specialist foot care. (iddt.org)
Glargine U100 was switched to degludec in those individuals with type 2 diabetes who achieved inadequate glycemic control or suffered from frequent hypoglycemic episodes or who required two injections per day, and changes in HbA1c level and frequency of hypoglycemic episodes during the 12-week period were compared. (iddt.org)
It was found that a greater difference in dose timing was related to a higher frequency of hypoglycemic episodes and overweight in persons with type 2 diabetes. (iddt.org)
The authors advise that fixed dose timing should be employed for basal insulin, because a larger difference in dose timing worsens diabetes-related factors. (iddt.org)
The approval of Apidra(R) for pediatric use is based upon FDA review of a 26-week, phase III, open-label, active control study of Apidra(R) in comparison with insulin lispro, in 572 children and adolescents (4 years and older) with type 1 diabetes. (redorbit.com)
Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to transport glucose (sugar) from the blood into the cells of the body for energy. (redorbit.com)
In type 1 diabetes, the immune system destroys the insulin-producing beta cells of the pancreas that regulate blood glucose. (redorbit.com)
Since the pancreas can no longer produce insulin, people with type 1 diabetes require daily injections of insulin for their entire lives. (redorbit.com)
Along with exercise, a basal insulin, and a proper meal plan, Apidra(R) is proven to help reduce A1C levels in adults and children (4 years and older) with type 1 diabetes and adults with type 2 diabetes. (redorbit.com)
When insulin is used in type 2 diabetes, a long-acting formulation is usually added initially, while continuing oral medications. (diabeteshelpcare.com)
UK-based AstraZeneca has reported results from its longest, randomised, head-to-head DURATION-3 trial of exenatide once-weekly, a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes in adult patients uncontrolled on oral antidiabetic drugs. (worldpharmatoday.com)
The trial compares a long-acting GLP-1 receptor agonist with basal insulin (insulin glargine) in type 2 diabetes patients with suboptimum glycaemic control despite maximum tolerated doses of metformin alone, or with a sulfonylurea. (worldpharmatoday.com)
Data from the trial published in the Lancet Diabetes and Endocrinology demonstrates that Bydureon (exenatide once-weekly injection) can achieve better glycaemic control with weight loss and less hypoglycaemia, compared with treatment from insulin glargine, over three years. (worldpharmatoday.com)
In addition, the ADA has added the elevation of HgbA1C (hemoglobin A1C, glycated hemoglobin, glycosylated hemoglobin) to greater than or equal to 6.5% done by standard assay (defined as National Glycohemoglobin Standardization Program certified and standardized to the Diabetes Control and Complications Trial assay), and this diagnostic testing is becoming more widely accepted (See Table I below). (renalandurologynews.com)
Dr. Thomas Blevins, M.D., lead investigator for the INSTRIDE clinical trials, said: "The availability of Semglee provides another quality treatment option for patients living with diabetes in the U.S. We rigorously compared Semglee (insulin glargine injection) to the reference insulin glargine in participants with Type 1 and 2 diabetes and found that Semglee yielded similar (non-inferior) glycemic results in both groups. (salesandmarketingnetwork.com)
Kiran Mazumdar-Shaw, Executive Chairperson, Biocon said: "The commercialization of our insulin glargine in the U.S. represents another milestone achievement for Biocon in making insulin-based therapy increasingly accessible for people with diabetes globally. (salesandmarketingnetwork.com)
In patients with type 1 diabetes , LEVEMIR® must be used in a regimen with rapid-acting or short-acting insulin. (rxlist.com)
The recommended starting dose of LEVEMIR® in patients with type 1 diabetes should be approximately one-third of the total daily insulin requirements. (rxlist.com)
The recommended starting dose of LEVEMIR® in patients with type 2 diabetes inadequately controlled on oral antidiabetic medications is 10 Units (or 0.1-0.2 Units/kg) given once daily in the evening or divided into a twice daily regimen. (rxlist.com)
The recommended starting dose of LEVEMIR® in patients with type 2 diabetes inadequately controlled on a GLP-1 receptor agonist is 10 Units given once daily in the evening. (rxlist.com)
However, some patients with type 2 diabetes may require more LEVEMIR® than NPH insulin, as observed in one trial [see Clinical Studies ]. (rxlist.com)
Should We Reconsider Treating Type 2 Diabetes with Insulin? (asweetlife.org)
Intensive insulin therapy or flexible insulin therapy is a therapeutic regimen for diabetes mellitus treatment. (wikipedia.org)
Long-term studies like the UK Prospective Diabetes Study (UKPDS) and the Diabetes control and complications trial (DCCT) showed that intensive insulinotherapy achieved blood glucose levels closer to non-diabetic people and that this was associated with reduced frequency and severity of blood vessel damage. (wikipedia.org)
A21Gly,B31Arg,B32Arg human insulin) on the day-to-day variability of fasting plasma glucose (FPG) levels in individuals with type 1 diabetes treated with basal-bolus insulin injections. (springer.com)
The effects of basal-bolus insulin therapy for 4 weeks with either IDeg or IGlar as the basal insulin in adult C-peptide-negative outpatients with type 1 diabetes were investigated in an open-label, multicentre, randomised, crossover trial. (springer.com)
IDeg yielded a lower FPG level and smaller day-to-day variability of FPG at a lower daily dose compared with IGlar in participants with type 1 diabetes. (springer.com)
IDeg serves as a good option for basal insulin in the treatment of type 1 diabetes. (springer.com)
In patients with type 1 diabetes who undergo basal-bolus insulin therapy with multiple daily injections, basal insulin is largely responsible for the stability of blood glucose levels in the fasting state. (springer.com)
1 2 Strict glycaemic control is critically important in people with type 2 diabetes. (bmj.com)
Patients with diabetes may require larger amounts of injectable insulin to keep blood glucose in an acceptable range. (veterinarypracticenews.com)
Objective To compare the effectiveness of insulin pumps with multiple daily injections for adults with type 1 diabetes, with both groups receiving equivalent training in flexible insulin treatment. (bmj.com)
Participants Adults with type 1 diabetes who were willing to undertake intensive insulin treatment, with no preference for pumps or multiple daily injections. (bmj.com)
Adding pump treatment to structured training in flexible intensive insulin treatment did not substantially enhance educational benefits on glycaemic control, hypoglycaemia, or psychosocial outcomes in adults with type 1 diabetes. (bmj.com)
People with type 1 diabetes mellitus require lifelong treatment with insulin to prevent diabetic ketoacidosis and to optimise blood glucose levels to minimise vascular complications. (bmj.com)

dose adjustments to short-acting insulin may be needed during transition periods. (drugs.com)
The remainder of the total daily insulin dose should be administered as a short-acting insulin and divided between each daily meal. (centerwatch.com)
Dr. Raskin, of the University of Texas, Dallas stated that, 'You can do better with two injections of a mix of intermediate and short acting insulin than you can with a single dose of glargine, a long-acting insulin,' particularly when baseline HbA1c values are high. (diabetesincontrol.com)
Regular insulin is the prototype of short-acting insulin, which is, unfortunately, an inappropriate description. (diabetesjournals.org)
Intravenous rapid-acting or short-acting insulin is the preferred treatment for this condition. (rxlist.com)
Why Do Long and Short Acting Insulin Pens Look Nearly Identical? (asweetlife.org)
She is on a slightly unusual regimen taking a short acting insulin preparation three times per day, with an intermediate acting preparation twice a day - at lunchtime and before bed. (2aida.org)
This 35 year old insulin-dependent diabetic man recently switched to using an insulin pen, injecting three 'shots' of short-acting insulin before breakfast, lunch and supper and taking a single dose of long-acting insulin before going to bed. (2aida.org)

RESULTS A total of 160 patients with comparable baseline characteristics formed four equal insulin regimen cohorts. (diabetesjournals.org)
In a basal-bolus regimen, insulin glargine (basal insulin) provides approximately one-third to one-half of the total daily insulin requirement while pre-meal insulin (i.e., short-acting [bolus] insulin) should be used to satisfy the remainder of the daily insulin requirement. (drugs.com)
Using a flexible dose regimen of insulin, the study enrolled Type I diabetics unable to achieve glycemic control on insulin alone. (centerwatch.com)
The addition of Symlin to this regimen significantly reduced mean HbA1c levels (-0.18%) and body weight (-3.0 kg) at 6 months, and reduced total, short-acting, and long-acting insulin (-12.0 +/- 1.36, -21.7 +/- 2.81, and -0.4 +/- 1.59 %, respectively), all relative to baseline. (centerwatch.com)
The trial enrolled 166 patients, who received 120 mcg Symlin in addition to a standard flexible-dose insulin regimen. (centerwatch.com)
It can be used once daily, twice daily, or as part of a thrice daily regimen (one IDegAsp and two IAsp doses). (springer.com)
At the end of the study all three measures were found to be consistently and significantly lower in the group that received the human insulin regimen that included the Oral-lyn product before meals. (medindia.net)
However, for individuals who cannot achieve HbA1c targets with basal insulin and OADs, questions may arise regarding other treatment options and how to introduce a further-intensified regimen. (springer.com)
Modify insulin regimen cautiously and only under medical supervision. (lantus.com)
All participants employed a self-directed treat-to-target insulin regimen based on a titration algorithm of (-2)-0-(+2) units to adjust their long-acting insulin dose every 3rd day from -3 mo through +9 mo to maintain fasting plasma glucose (FPG) between 90-120 mg/dL (5.0-6.7 mmol/L). Pubertal maturation was determined by Tanner stage. (diabetesincontrol.com)
Make changes to a patient's insulin regimen (e.g., insulin strength, manufacturer, type, injection site or method of administration) under close medical supervision with increased frequency of blood glucose monitoring. (dtg41r.com)
The majority of the patients received insulin glargine as part of their basal-prandial regimen (69.7% and 72% in the Apidra(R) and insulin lispro treated groups, respectively). (redorbit.com)
He or she will work with you to ensure that your dental self-care regimen is maximized to prevent or control your dental disease. (diabeteshelpcare.com)
These three components of the insulin regimen are commonly referred to as basal insulin, bolus insulin, and high glucose correction insulin. (wikipedia.org)
In an MDI regimen, long-acting insulins are preferred for basal use. (wikipedia.org)
He is currently on a regimen of combined short and / or intermediate acting insulin preparations four times per day. (2aida.org)
See if you can adjust his insulin regimen so that his blood sugars don't run quite so low in the morning. (2aida.org)

Insulin regimens should be modified cautiously and only under medical supervision. (news-medical.net)
In addition to maintained standard insulin regimens, subjects received an initial dose of 15 mcg Symlin or placebo, which was titrated in 15 mcg intervals to 30 mcg or 60 mcg, based on whether subjects experienced significant nausea. (centerwatch.com)
Patients received Symlin or placebo, in addition to the patients existing regimens of fixed dose insulin with or without metformin and/or sulfonylurea. (centerwatch.com)
This update covers a warning that differences in dosing regimens between the 2 oral formulations of posaconazole (Noxafil) have resulted in dosing errors. (acpinternist.org)
Until pharmacological advancements create easier, more acceptable insulin regimens, it is imperative to involve patients in shared decision-making. (diabetesjournals.org)
Many people on MDI regimens carry insulin pens to inject their rapid-acting insulins instead of traditional syringes. (wikipedia.org)

The use of insulin is usually postponed and patients experience a prolonged period of hyperglycemia. (renalandurologynews.com)
Insulin should be added as soon as there is a trend towards hyperglycemia. (renalandurologynews.com)
The choice of insulin depends on the type of hyperglycemia experienced by the patient. (renalandurologynews.com)
Patients with mostly post-prandial hyperglycemia will not be adequately controlled with basal insulin alone, and will require prandial insulin. (renalandurologynews.com)
History of previous glycemic control should be reviewed and control should be improved in symptomatic and asymptomatic patients with sustained hyperglycemia, reflected by a fasting blood glucose (FBG) level higher than 200 mg/dL, high HbA1c values (>10%), or both. (diabetesindia.com)
Elevated blood sugar (hyperglycemia) can have long-term detrimental effects on the heart, blood vessels, eyes, kidneys, and nerves. (ptcommunity.com)
Reduced beta cell mass and/or insulin resistance is associated with relative or absolute hypoinsulinemia and relative hyperglucagonemia-conditions that promote excessive glucose output from the liver, resulting in hyperglycemia. (todaysveterinarypractice.com)
In addition, any increase in glucose that occurs during the absorptive phase of digestion cannot be blunted by insulin release, which contributes to postprandial hyperglycemia. (todaysveterinarypractice.com)
Endogenous hormones produced in response to infection can cause insulin resistance and hyperglycemia. (veterinarypracticenews.com)

At 6 months, subjects receiving Symlin plus insulin achieved similar reductions in mean HbA1C levels, compared to subjects receiving placebo-plus-insulin (-0.47 +/- 0.07 % vs. -0.49 +/- 0.07 %, respectively), while using a significantly lower total and fast-acting insulin dose (-11.7%, -22.8% from baseline). (centerwatch.com)
Symlin was found to produce significantly superior improvements in reduction in HbA1c levels (-.57 %), placebo-subtracted HbA1c levels (-0.40 %), body weight (-1.5 kg), placebo-subtracted body weight (-1.7 kg), % change in rapid-acting insulin dose (-3.0 %), and % change in long-acting insulin dose (-0.2 %), at 6 months. (centerwatch.com)
At week 12, 110 study subjects achieved FBG ≤6.5 mmol/L, of whom 66 did not achieve HbA1c ≤7% and therefore initiated prandial insulin. (springer.com)
Measurement of HbA1c levels is the best method for medium-term to long-term diabetic control monitoring. (medscape.com)
To confirm the observed reduction in HbA1c for the 2.5 mg dose in EASE-3 by modelling and simulation analyses.Independent of data from EASE-3 that tested 2.5 mg, we simulated the effect of a 2.5 mg dose through patient-level, exposure-response modelling in the EASE-2 clinical study. (tripdatabase.com)
insulin dose adjustments made after treatment initiation that potentially limited HbA1c reductions. (tripdatabase.com)
The model was informed by pharmacokinetic, insulin dose , mean daily glucose and HbA1c data, and was verified by comparing the simulations with the observed HbA1c change in EASE-3. (tripdatabase.com)
23 For form 2 diabetics with a poorly controlled HbA1c, the exercising program should begin steadily. (racernm.com)
This was an observational, cross-sectional study and involved assessment of HbA1c levels as a surrogate marker of the metabolic control in all patients seen during a regular four month interval at our outpatient clinic. (smw.ch)
The study compared the efficacy of Apidra(R) to insulin lispro in terms of change in glycohemoglobin (HBA1c), which is the amount of sugar bound to hemoglobin in the blood. (redorbit.com)
The change in HBA1c from baseline to endpoint for Apidra(R) and insulin lispro were similar. (redorbit.com)
Conclusions Both groups showed clinically relevant and long lasting decreases in HbA1c, rates of severe hypoglycaemia, and improved psychological measures, although few participants achieved glucose levels currently recommended by national and international guidelines. (bmj.com)

Glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) in particular also have effects on gastric motility and satiety that provide significant benefits for postprandial glycemic excursions ( 11 ). (diabetesjournals.org)
These drugs are used to control postprandial high glucose levels, that is, high glucose levels after a meal. (medindia.net)
In this context, a single integrated microneedle patch (IMP) with multiple release kinetics is demonstrated to provide better physiologic insulin coverage for postprandial glycemic excursion in a convenient and pain-free manner. (sciencemag.org)
Postprandial glycemic control, as assessed by the self-monitored blood glucose values and blood glucose excursions, was similar in both treatment groups at endpoint. (redorbit.com)

Insulin analogs can cost up to three times as much as insulin, however, which can place serious financial strains on families that pay for their own insulin. (medindia.net)
Even families with comprehensive drug coverage will find that plans charge a significantly higher co-pay for insulin analogs than for "regular" human insulin. (medindia.net)
Claims that analogs provide superior convenience do have some merit when these agents are compared with insulin injected before meals. (medindia.net)
New insulin analogs more closely mimic the kinetic profile of endogenous insulin and allow for flexible dosing in pen devices that are generally well received by patients. (diabetesjournals.org)
Clinical outcome data, together with the safety and convenience of insulin analogs and newer insulin-delivery devices, may make early initiation of insulin therapy more attractive. (diabetesjournals.org)
1 - 4 With the recent introduction of two new insulin analogs, it seems appropriate to review insulin therapy for primary practitioners. (diabetesjournals.org)
Insulin analogs provide flexibility in the delivery of insulin therapy for this population. (jaoa.org)

In this study there was a forced titration of insulin, based on two preceding fasting blood glucose levels. (renalandurologynews.com)
This class of injectable drugs decreases fasting blood glucose levels and improves long-term glycemic control while inducing mild to moderate weight loss in most patients ( 7 ). (sciencemag.org)
Optimal diabetic control requires frequent self-monitoring of blood glucose levels, which allows rational adjustments in insulin doses. (medscape.com)
Most patients with T2DM eventually require insulin if other medications fail to control their blood glucose levels adequately. (jaoa.org)
Rapid-acting insulin products target-controlling, after-meal, blood glucose levels, or reducing blood glucose in response to an elevated blood glucose measurement, as in a correctional scale. (statpearls.com)
As pregnancy progresses, the placenta also produces insulin-blocking hormones, which might result in a woman's blood-glucose levels becoming elevated if there isn't enough insulin to counter this effect. (diabeteshelpcare.com)
She wants to start a family, but consistently has had quite high blood glucose levels in the early afternoon, despite numerous attempts to normalise her control in anticipation of becoming pregnant. (2aida.org)
However, he hasn't quite yet got full control of his blood sugars, still tending towards high blood glucose levels overnight. (2aida.org)

During clinical trials, patients receiving insulin glargine U-300 required 17.5% greater dose than patients treated with insulin glargine U-100. (drugs.com)

Treatment beyond lifestyle changes generally begins with oral antidiabetic agents, but these medicines only have transitory benefit, and the progressive nature of T2D requires therapeutic intensification to include insulin within 5 to 10 years for many patients ( 2 - 4 ). (sciencemag.org)
Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in insulin dose or an adjustment in concomitant oral antidiabetic treatment. (lantus.com)

The percent reduction in daily insulin dose was positively correlated with β-cell function at baseline, and two patients discontinued insulin treatment. (diabetesjournals.org)
Primary endpoints were change from baseline to year four in A1C, and long-term safety and tolerability. (drugs.com)
These imbalances can occur in diabetic and non-diabetic patients and involve a complex relationship between patient factors such as baseline glucose control and underlying comorbidities and surgical/operative factors such as procedure complexity and type of anesthesia. (oncologynurseadvisor.com)
Assess baseline glycemic control. (oncologynurseadvisor.com)
270 mg/dL (15 mmol/L)) on stable baseline therapy (insulin alone or insulin combined with metformin, with insulin at doses of ≥20 and ≤150 units per day total) for at least eight weeks at the time of screening. (clinicaltrials.gov)
The analysis will be performed on the Full analysis Set (FAS) consisting of randomised subjects who received at least 1 randomised investigational product dose and had at least 1 non-missing baseline and 1 post-baseline efficacy assessment. (clinicaltrials.gov)
If someone is insulin deficient -- and a T2 can be both hyperinsulinemic at baseline and GSIS-impaired -- low carbers should not be so hostile towards those who use it. (blogspot.com)

and if these fail, then to start anti-diabetic agents at or soon after the diagnose and/or insulin therapy ( 3 , 4 ). (frontiersin.org)
Adding a basal insulin to oral hypoglycemic therapy is relatively simple and has the advantage of easing a patient into insulin therapy slowly. (renalandurologynews.com)
It is critical that insulin therapy not be delayed. (renalandurologynews.com)
Patients with high fasting blood sugars are good candidates for adding basal insulin therapy to their oral agents. (renalandurologynews.com)
The addition of basal insulin therapy to oral hypoglycemic treatment is relatively simple. (renalandurologynews.com)
However, basal insulin therapy added to oral hypoglycemic agents results in good glycemic control in only a small proportion of patients. (renalandurologynews.com)
In this study, oral hypoglycemic therapy was continued, but insulin was added in the form of either glargine or NPH. (renalandurologynews.com)
NOTE: Initiation of Symlin therapy may require adjustments to insulin dosing schedules, and should be performed under the close supervision of a healthcare professional. (centerwatch.com)
Symlin was also investigated in an open-label clinical practice study in the treatment of Type II diabetics whose disease was inadequately controlled by insulin therapy. (centerwatch.com)
We hypothesized that the beneficial effect of insulin therapy in the DIGAMI trial was due to an improvement of vascular endothelial function. (diabetesjournals.org)
Intensified therapy is an approach to achieving established levels of glycemic control. (diabetesjournals.org)
This empowers patients to take charge of their glycemic control and provides feedback on the timing and dose of pharmacological therapy (insulin and/or oral agents). (diabetesjournals.org)
SMBG and intensified therapy assist the gravida to achieve glycemic control and enhance perinatal outcome at a lower cost than conventional management. (diabetesjournals.org)
Herein, evidence in favor of early insulin therapy on disease progression and long-term outcomes will be reviewed and placed into clinical context. (diabetesjournals.org)
Ultimately, most patients will require insulin therapy, although insulin is still all too often thought of as "last resort" or "end-stage" therapy. (diabetesjournals.org)
This and other misperceptions frequently limit the early initiation of insulin therapy, even among patients for whom oral agents are no longer adequate. (diabetesjournals.org)
The main drawback of these studies was the small sample size and lack of reporting on long-term benefit and safety of adjunctive therapy in many of them. (diabetesincontrol.com)
To address this question, we conducted a 12-month clinical trial consisting of a 3-month run-in-phase and a 9-month randomized, double-blind, placebo-controlled interventional period to determine the role of adjunctive metformin therapy on glycemic control in youth with T1D who have excess weight or obesity. (diabetesincontrol.com)
The interventions are 26 weeks liraglutide or 26 weeks cognitive behavioral therapy added to insulin therapy and usual care. (trialregister.nl)
Therefore, insulin therapy associated weight gain should be prevented. (trialregister.nl)
Insulin may be the desired therapy in individuals with T2DM with critical beta-cell failure with significant glucotoxicity, intolerance to or failure of oral anti-hyperglycemic therapy, or patient preference. (dovepress.com)
The present article reviews how the role of insulin continues to evolve, from its earlier use in the treatment paradigm (even at first diagnosis) to its role in combination therapy with incretin-based therapies, as well as new formulations that provide more-convenient forms of insulin replacement therapy. (jaoa.org)
As a result of improvements in health care and increases in longevity, patients are more likely to require insulin therapy at some point during the progression of T2DM. (jaoa.org)
With advances in insulin therapy still occurring, it is well worth keeping up to date on trends in the use of this powerful glucose-lowering agent. (jaoa.org)
1 Insulin replacement therapy lets patients know that a key component of their natural glucose-regulating system is being restored. (jaoa.org)
2 The present review article discusses initiation of insulin replacement therapy at the time of diagnosis, basal insulin therapy used in combination with incretin therapy, and second-generation basal insulin analog therapy, using a case study to demonstrate clinical application. (jaoa.org)
Intensive insulin therapy (IIT) has been shown to decrease post-operative infection rates and improve mortality in cardiac surgery patients. (oncologynurseadvisor.com)
These invasiveness and discomfort, in a sense, directed exploitations in insulin therapy to alternative nonparenteral delivery systems that are less invasive and lack of pain ( 4 ). (sciencemag.org)
They benefited from lipid-control therapy with pravastatin started some months after the event. (practicalpointers.org)
The Lantus dose is not that substantial and imposes a much higher burden for administration and monitoring than oral therapy. (meded101.com)
Actually, it is very common for us to continue glipizide when we add insulin-ie BIDS therapy (bedtime insulin daytime sulfonylurea), here we are using the SFU to get additional prandial coverage. (meded101.com)
The major drawback of insulin therapy is its invasive nature. (hkmj.org)
Apidra(R) can also be used in insulin infusion pump therapy for blood sugar control. (redorbit.com)
Intensive or flexible therapy involves supplying a continual supply of insulin to serve as the basal insulin, supplying meal insulin in doses proportional to nutritional load of the meals, and supplying extra insulin when needed to correct high glucose levels. (wikipedia.org)
The other method of intensive/flexible insulin therapy is an insulin pump. (wikipedia.org)
A21Gly,B31Arg,B32Arg human insulin) is a long-acting insulin analogue that is widely administered as a basal insulin in basal-bolus therapy. (springer.com)

To characterize the pharmacologic effects of FGF21, we administered a long-acting FGF21 analog, PF-05231023, to obese cynomolgus monkeys. (mendeley.com)
Tresiba (insulin degludec) is a long-acting human insulin analog. (centerwatch.com)
The control study group received insulin glargine (an insulin analog) once a day as their basal dose, and a faster-acting insulin analog before meals. (medindia.net)
Insulin lispro (Humalog) is an insulin analog that differs from human insulin in amino acid sequence but binds to insulin receptors and thus functions in a manner similar to human insulin. (diabetesjournals.org)
Concentrated formulations appear to behave as separate molecular entities when compared with earlier U100 insulin analog compounds. (dovepress.com)
Over the long term, we expect this addition to our portfolio to play an increasingly important role within our global biosimilars and insulin analog franchise as well as our efforts to advance access to complex medicines. (salesandmarketingnetwork.com)
LEVEMIR® is a recombinant human insulin analog for once- or twice-daily subcutaneous administration. (rxlist.com)

Treatment - diet, oral hypoglycemic agents (OHA) or insulin. (diabetesindia.com)
Oral hypoglycemic agents, insulin, and exercise are the primary methods of treatment. (thefreedictionary.com)
Both result in fewer hypoglycemic episodes compared to regular insulin. (diabetesjournals.org)
This review highlights the published reports of the pharmacokinetic (PK) and glucodynamic properties of concentrated insulins: Humulin-R U500, insulin degludec U200, and insulin glargine U300, describes the clinical efficacy, risk of hypoglycemic, and metabolic changes observed, and finally, discusses observations about the complexity of introducing a new generation of concentrated insulins to the therapeutic market. (dovepress.com)
Patients who have adequate glycemic control and minimal hypoglycemic events with NPH insulin will likely not derive additional benefit from insulin glargine (in most studies, insulin glargine did not significantly reduce fasting blood glucose, fasting plasma glucose, or hemoglobin A1c compared to NPH insulin). (york.ac.uk)

Apidra(R) is a rapid-acting insulin that can be administered using an insulin infusion pump, vial and syringe, the OptiClik(R) reusable insulin pen, or intravenously under proper medical supervision in a clinical setting. (redorbit.com)
An insulin pump can be programmed to infuse a steady amount of rapid-acting insulin under the skin. (wikipedia.org)

The aim of this study is to compare the sustained efficacy of basal and premixed insulin therapies in T2DM outpatients with insulin monotherapy. (frontiersin.org)
A total of 49,119 T2DM outpatients on basal ( n = 11,967) or premixed insulin ( n = 37,152) monotherapy were included in the final analyses. (frontiersin.org)
7.0%) than basal insulin monotherapy for Chinese T2DM outpatients in daily. (frontiersin.org)
This study assessed the efficacy and safety of basal insulin dose optimization followed by the addition of prandial insulin in Chinese people with T2DM achieving suboptimal glycemic control with basal insulin and OADs. (springer.com)
In this open-label, single-arm study, adults with T2DM receiving basal insulin plus OADs underwent insulin dose optimization for 12 weeks. (springer.com)
However, due to the chronic and progressive nature of T2DM, achieving glycemic control becomes increasingly difficult as the disease advances. (springer.com)
Patients with T2DM are insulin resistant, have relatively low insulin production, or have both characteristics. (jaoa.org)
Insulin is instrumental in managing T2DM, which is a complex, multihormonal, and progressive chronic disease. (jaoa.org)

The addition of insulin can result in better glycemic control, as evidenced by a decline in glycated hemoglobin levels. (renalandurologynews.com)

Three laboratory measures are recommended to gauge the level of glycemic control attained by individual patients ( Table 1 ). (diabetesjournals.org)

Dose adjustments may be needed with changes in physical activity, changes in meal patterns, during acute illness, or with changes in renal or hepatic function. (drugs.com)
Frequent adjustments of dietary intake and insulin dosage are required. (thefreedictionary.com)
Capillary blood glucose monitoring provides the feedback for suitable adjustments to the timing and dose of insulin administration. (diabetesjournals.org)
Appropriate patient selection, careful patient instruction, and insulin dose adjustments are critical elements for reducing the risk. (ndei.org)
15 , 27 Guidelines are available to estimate carbohydrate desires and insulin adjustments for athletes. (racernm.com)
Adjustments to medications, which includes doses of insulin, also could be necessary, but this must be carried out below the supervision of your physician. (racernm.com)
Blood glucose monitoring and insulin dose adjustments are recommended to achieve optimal glycaemic control. (lynchspharmacy.com)

All C-peptide-positive patients were treated with liraglutide plus insulin, whereas C-peptide-negative patients were randomly assigned to liraglutide plus insulin or insulin monotherapy. (diabetesjournals.org)
0.01) in C-peptide-negative patients treated with liraglutide but did not change with insulin monotherapy. (diabetesjournals.org)

Miglitol may also be used in combination with a sulfonylurea when diet and exercise plus either miglitol or a sulfonylurea alone does not result in adequate glycemic control. (ndei.org)

Conversely, ongoing chronic infection affects the body's ability to maintain glycemic control. (veterinarypracticenews.com)

Not surprisingly, poor glycemic control further adds to this risk. (diabeteshelpcare.com)

Previous works associated with insulin-based MN systems mainly focused on bolus insulin delivery without delaying or prolonging the dissolution or absorption of insulin ( 7 ). (sciencemag.org)
Nevertheless, the sustained or kinetically controlled delivery is more preferable than bolus insulin delivery and is essential to fulfill the full potential of transdermal delivery for maintaining drug concentrations within a therapeutic range over a predetermined period of time ( 8 ). (sciencemag.org)
Bolus insulin is produced during the digestion of meals. (wikipedia.org)

In the patients and 10 healthy control subjects, ACh was repeated after intrabrachial infusion of insulin. (diabetesjournals.org)
Insulin infusion raised venous serum insulin in the forearm to high physiological levels (133 ± 14.6 mU/l in patients) with a minor increase in systemic venous serum insulin. (diabetesjournals.org)
Do not administer HUMULIN 70/30 intravenously or intramuscularly and do not use HUMULIN 70/30 in an insulin infusion pump. (rxlist.com)
Currently available insulin delivery systems include insulin syringes, infusion pumps, jet injectors, and pens. (hkmj.org)
This steady infusion is termed the basal rate and is designed to supply the background insulin needs. (wikipedia.org)

OBJECTIVE To investigate the effect of 4 weeks of treatment with liraglutide on insulin dose and glycemic control in type 1 diabetic patients with and without residual β-cell function. (diabetesjournals.org)
CONCLUSIONS Treatment with liraglutide in type 1 diabetic patients reduces insulin dose with improved or unaltered glycemic control. (diabetesjournals.org)
For Type II patients, initial dose should be 60 mcg, with a single increment increase to 120 mcg as tolerated. (centerwatch.com)
Approval of Symlin was supported by a number of clinical trials, investigating the drug in both Type I and Type II diabetic in both short- and long-term controlled trials, long term uncontrolled trials, and an open label study. (centerwatch.com)
Symlin was evaluated for the treatment of Type I diabetics (n=1717) in 3 long-term randomized, double-blind, placebo-controlled studies. (centerwatch.com)
Metformin when used for patients with type 2 has been found to significantly reduce blood sugars and help to help to lose weight and to prevent weight gain when using insulin. (diabetesincontrol.com)
Know the type and strength of insulin you take. (salesandmarketingnetwork.com)
Metabolic control of type 1 diabetic patients followed at the University Children's Hospital in Berne: Have we reached the goal? (smw.ch)
Metabolic control of type 1 diabetic patients followed at the University Children's Hospital in Bern: Have we reached the goal? (smw.ch)
Always make sure that you receive the correct type of insulin from the pharmacy. (humalog.com)
In a small phase II placebo-controlled trial the SGLT2 inhibitor dapagliflozin improved glycemic control and reduced insulin needs in type 1 diabetic subjects [ 1 ]. (hindawi.com)
The genes identified so far in people with type 2 include many that affect the insulin-producing beta cells of the pancreas, says Craig Hanis, PhD, a professor at the Human Genetics Center at the University of Texas Health Science Center in Houston. (diabeteshelpcare.com)
Main outcome measures Associations between sulphonylurea dose, renal impairment, type of sulphonylurea used, and risk of hypoglycaemia, were determined using Cox proportional hazard models. (bmj.com)
This man is a relatively newly diagnosed insulin-dependent (type 1) diabetic patient. (2aida.org)
This overweight 58 year old insulin-dependent (type 1) diabetic patient has had major problems losing weight. (2aida.org)

Infusions of IV dextrose can worsen glucose control, which can increase the demand on already dysfunctional pancreatic islet cells. (todaysdietitian.com)
Sulfonylureas are insulin secretogogues acting to stimulate pancreatic beta-cell insulin production. (racernm.com)
Insulin is released from pancreatic beta cells, and is the principal hormone responsible for lowering blood glucose. (todaysveterinarypractice.com)
There have been many advances in insulin drug delivery from its first administration as a crude pancreatic extract till today. (hkmj.org)
To carry on with the experiments in a larger number of animals, a substantial quantity of insulin was needed so pancreatic extract from cows started being used. (hkmj.org)

It also considered the effects of ultra-long-acting insulin (insulin degludec) in this context. (iddt.org)
Des(B30)LysB29(γ-Glu Nε-hexadecandioyl) human insulin) is a novel ultra-long-acting insulin analogue that was first launched in the UK in January 2013 and is now available in several European and Asian countries including Japan. (springer.com)

At the end of study (n = 866), 11.0% patients treated with the 0.3 U/kg starting insulin dose experienced overall confirmed hypoglycaemia versus 8.6% of patients treated with 0.2 U/kg (estimated difference 2.1%, 95% confidence interval - 1.68, 5.89). (tripdatabase.com)
Secondary endpoints included serum glycoalbumin level, daily dose of insulin, intraday glycaemic variability and frequency of severe hypoglycaemia. (springer.com)
We wondered whether nifedipine could be used safely as long term treatment to counter hypoglycaemia in persistent hyperinsulemic hypoglycaemia of infancy (PHHI)? (bestbets.org)
The risk of hypoglycaemia was also significantly higher in patients with a high sulphonylurea dose (3.12, 2.68 to 3.62) and in current users of glibenclamide (7.48, 4.89 to 11.44). (bmj.com)
Secondary outcomes included body weight, insulin dose, and episodes of moderate and severe hypoglycaemia. (bmj.com)
Glycaemic control and rates of severe hypoglycaemia improved in both groups. (bmj.com)

Traditional treatment guidelines for exercise emphasizing the reduction of insulin doses and/or ingestion of additional carbohydrates are of limited applicability for patients treated with ultra-long acting basal insulin analogues. (clinicaltrials.gov)
Genzyme's clinical development program for the Lemtrada included two phase-3 studies in which results for Lemtrada were superior to Rebif (high dose subcutaneous interferon beta-1a) on clinical and imaging endpoints, including a reduction in relapse rate. (drugstorenews.com)
Reduction in risk of myocardial infarction was of borderline significance with intensive glycemic control ( P = 0.052). (diabetesjournals.org)
Furthermore, discontinuation or dose reduction of ACTOS ® , ACTO plus met ® , or duet act™ must be considered. (ndei.org)
A reduction in the Lantus ® dose may be required in patients with renal or hepatic impairment. (lantus.com)
One major problem with these drugs is in case of a high dose, they can bring about an excessive reduction in blood glucose, which may give rise to symptoms like fainting. (medindia.net)
Insulin-treated patients with T2D and obesity are challenged achieving body weight stability or reduction, in addition to glycemic control. (bioportfolio.com)

In T1DM, basal insulin in combination with rapid-acting mealtime insulin provides a close but imperfect substitute for endogenous physiologic insulin production. (dovepress.com)

There is a beneficial carryover effect on glycemic levels later in the day, resulting in a lowering of glycated hemoglobin. (renalandurologynews.com)

These insulins start working faster than other insulins that contain regular human insulin. (humalog.com)

Commonly used insulin secretagogues include the sulfonylureas (glyburide, glipizide, gliclazide and glimepiride), repaglinide and nateglinide. (medindia.net)
Specifically, I look at the use of sulfonylureas with long acting insulin. (meded101.com)
With an A1C value reported at 6.1 and an already substantial dose of Lantus, this is a classic example where you could look at discontinuing the low dose sulfonylurea (remember that sulfonylureas stimulate insulin release) and monitor the A1C and accuchecks going forward. (meded101.com)

It is caused by destruction of islet cells (the cells in the pancreas that make insulin) as well as a decrease in sensitivity of the liver and muscles to the actions of insulin. (thefreedictionary.com)
Metformin is a biguanide, which acts principally by increasing insulin sensitivity in the liver by inhibiting hepatic gluconeogenesis and thereby reducing hepatic glucose output. (diabetesincontrol.com)
Increase in sensitivity of tissues to insulin. (medindia.net)
Insulin sensitivity was derived from the Quantitative Insulin Sensitivity Check Index (QUICKI), Oral Glucose Insulin Sensitivity Index (OGIS) in OGTT and surrogate index of SI from the minimal model (calculated SI, CSI). (bmj.com)
Conclusions Asian YT2DM showed similar GLP-1 response to oral glucose as controls but reduced incretin effect, BC and insulin sensitivity. (bmj.com)
6.0%, both insulin sensitivity and ß-cell function decrease markedly. (glycosmedia.com)

It is designed to mimic the activity of the naturally occurring hormone amylin, which is secreted together with insulin and is involved in post-prandial glucose control. (centerwatch.com)
Higher readings generally indicate less-effective glucose control. (medindia.net)
However, despite their unique mechanism of action and solid clinical track record, even GLP-1RAs are not entirely sufficient for chronic glucose control in patients with T2D, and the weight loss induced by these drugs rarely corrects obesity. (sciencemag.org)
Surgery and general anesthesia frequently lead to imbalances in glucose control, both intra-operatively and in the peri-operative period. (oncologynurseadvisor.com)
In the pre-operative clinic the Hospitalist must assess the surgical suitability of patients with disorders of glucose control. (oncologynurseadvisor.com)
Also in the pre-operative setting, the Hospitalist is expected to formulate a plan for management of glucose control in the days leading up to surgery. (oncologynurseadvisor.com)
Structure a plan for peri-operative glucose control that is tailored to the individual patient setting with attention to patient, operative, anesthetic and anticipated post-operative factors. (oncologynurseadvisor.com)
Thus, a major challenge for veterinarians caring for established diabetics in the hospital is to provide needed care while avoiding significant disruption of glucose control. (todaysveterinarypractice.com)

Independent adjustment of the basal or prandial dose is not possible when using a premixed insulin. (rxlist.com)
Three patients discontinued prandial insulin due to dissatisfaction with treatment outcome ( n = 1), accidental injury ( n = 1), or personal reasons ( n = 1). (springer.com)
it uses a long-acting basal insulin to control FBG and a short-acting prandial insulin bolus to control PBG. (springer.com)
This meal-associated (prandial) insulin production is roughly proportional to the amount of carbohydrate in the meal. (wikipedia.org)

We expected treatment effect to be smallest in the C-peptide-negative group, and because eligible C-peptide-positive patients are difficult to recruit, we only included C-peptide-negative patients as control subjects. (diabetesjournals.org)
PF-05231023 treatment led to dose-dependent changes in multiple markers of bone formation and resorption and elevated insulin-like growth factor 1. (mendeley.com)
The tolerability of BYDUREON also improved over time with long-term treatment," said Christian Weyer, M.D., senior vice president, research and development, Amylin Pharmaceuticals. (drugs.com)
We show that once-weekly dual-agonist treatment of diabetic mice results in potent weight-reducing effects and enhanced glycemic control that are not observed with either agonist alone. (sciencemag.org)
The advent of GLP-1RAs has added a notable dimension to T2D management, allowing a greater number of patients to reach their glycemic targets than was previously achieved with conventional medicines ( 7 ), and these agents are now recommended before insulin for treatment of T2D ( 8 ). (sciencemag.org)
Several treatment options including various insulin preparations are available, but glycemic control remains suboptimal. (naceonline.com)
Both groups continued treatment with insulin sensitizers. (diabetesincontrol.com)
All patients should be monitored for symptom worsening or suicidality, especially at treatment initiation or after dose changes. (pdr.net)
Glycemic control in diabetic dogs and cats may be jeopardized by hospitalization for treatment of diabetic or nondiabetic disorders or routine health care interventions, such as minor surgical procedures or dental prophylaxis. (todaysveterinarypractice.com)
The combination of insulin degludec and liraglutide in a single pen does not allow the dosage of each substance to be adjusted independently, in particular at the start of treatment or in the case of an adverse effect. (prescrire.org)
These patients received concomitant treatment with insulin glargine once daily or NPH twice daily as basal insulin. (redorbit.com)
Doses and timing of concurrent rapid-acting or short-acting insulins or other concomitant antidiabetic treatment may need to be adjusted. (rxlist.com)
Initially, high doses of glucose infusions are required to establish euglucaemia, traditionally followed by a treatment with either diazoxide or long acting somatostatin (octreotide), sometimes combined with dietary measures (high in starch, glucose or protein) (5). (bestbets.org)
Participants were allocated a place on established group training courses that taught flexible intensive insulin treatment ("dose adjustment for normal eating," DAFNE). (bmj.com)

Dose reductions may require two to three days for modern basal insulin analogues in order to achieve an adapted steady state, hereby increasing the risk of inadequate insulin-following exercise. (clinicaltrials.gov)
As a consequence for patients treated with modern basal insulin analogues, it seems more adequate not to modify insulin doses but to apply alternative strategies for recreational exercise. (clinicaltrials.gov)
The presence of two distinct insulin analogues as a soluble co-formulation of a basal component with an ultra-long duration of action makes IDegAsp an advance over earlier premix insulins. (springer.com)
Our results clearly show that over the course of a year-long study the advantage of these analogues is equaled or improved upon by the use of Oral-lyn. (medindia.net)
When Oral-lyn is absorbed through the buccal mucosa its rapid entry into the blood stream mimics and improves upon the rapid acting analogues. (medindia.net)

Although premixed insulin is one option to avoid some of these barriers, in clinical practice not all patients using premixed insulin can achieve adequate control of blood glucose due to limited doses and the fixed insulin component. (springer.com)
This report describes novel clinical data assessing pharmacodynamics of insulin glargine/lixisenatide (iGlarLixi) compared with placebo and insulin glargine alone, to determine pharmacokinetics of lix. (bioportfolio.com)

Anatomy10

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Phenomena and Processes34

Anthropology, Education, Sociology and Social Phenomena3

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Insulin detemir

Intensive insulin therapy

Minimed Paradigm

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Insulin (medication)

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Saxagliptin

Insulin analog

Diabetes mellitus type 1

Insulin pump

Diabetic retinopathy

Anti-diabetic medication

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Diabetes mellitus

Insulin

Injector pen

AIDA interactive educational freeware diabetes simulator

Obesogen

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Mark Mattson

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Glossary of diabetes

Diabetes

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Acne

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Type 2 diabetes

Diabetes mellitus type 2

Gestational diabetes

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Chromium(III) picolinate

Frontiers | Comparison of the Effect of Glycemic Control in Type 2 Diabetes Outpatients Treated With Premixed and Basal Insulin...

Four Weeks of Treatment With Liraglutide Reduces Insulin Dose Without Loss of Glycemic Control in Type 1 Diabetic Patients With...

Patients with type 2 diabetes who intensify with bolus insulin step by step obtain the same glycemic control as patients...

A long-acting FGF21 molecule, PF-... preview & related info | Mendeley

BYDUREON Was Associated with Significant and Sustained Glycemic Control at Four Years - Drugs.com MedNews

Can insulin dosing be reduced without compromising glycemic control in type 2 diabetes mellitus (DM)?

Lowest Glucose Variability and Hypoglycemia Are Observed With the Combination of a GLP-1 Receptor Agonist and Basal Insulin ...

Insulin Glargine Dosage Guide with Precautions - Drugs.com

Lantus, Toujeo (insulin glargine) dosing, indications, interactions, adverse effects, and more

Fructose in Exercising Individuals With Type 1 Diabetes Using Insulin Degludec - Full Text View - ClinicalTrials.gov

Tresiba and Ryzodeg approved to improve blood sugar control in adults with diabetes mellitus

Early Insulin Usage in the Outpatient Setting - Renal and Urology News

Tresiba New FDA Drug Approval | CenterWatch

AP-05-002 A Safety and Efficacy Study of Oral Danazol (a Previously Approved Drug)in the Treatment of Diabetic Macular Edema -...

Symlin New FDA Drug Approval | CenterWatch

Insulin Therapy Improves Insulin-Stimulated Endothelial Function in Patients With Type 2 Diabetes and Ischemic Heart Disease |...

Warning about different doses for 2 forms of posaconazole | ACP Internist

Global study reveals correlation between insulin dosing irregularities, hypoglycemia - Drug Store News

Multinational Consensus: Insulin Initiation with Insulin Degludec/Aspart (IDegAsp) | SpringerLink

Humulin 70-30 (Insulin (Human Recombinant)): Side Effects, Interactions, Warning, Dosage & Uses

Parenteral Feeding in Diabetes Patients - RDs Can Play a Pivotal Role in Glycemic Control

Novo Nordisk's New Ultra-Long-Acting Insulin Degludec Shows Lower Rate of Hypoglycemia

Insulin Analogs No Better Than the Real Deal

PDF] Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in...

Diabetes India - Diabetes and Surgery

Adding Prandial Insulin to Basal Insulin Plus Oral Antidiabetic Drugs in Chinese Patients with Poorly Controlled Type 2...

FDA: REMS No Longer Needed for Inhaled Insulin Afrezza - MPR

FDA: REMS No Longer Needed for Inhaled Insulin Afrezza - MPR

DM | definition of DM by Medical dictionary

Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia |...

Improve glycemic control15

Secretion26

Aspart36

Diabetes199

Short-acting8

Regimen17

Regimens6

Hyperglycemia9

HbA1c12

Postprandial4

Analogs7

Blood glucose levels8

Treated with insulin glargine1

Oral antidiabetic2