Motor Neurons: Neurons which activate MUSCLE CELLS.Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Phrenic Nerve: The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Respiratory Center: Part of the brain located in the MEDULLA OBLONGATA and PONS. It receives neural, chemical and hormonal signals, and controls the rate and depth of respiratory movements of the DIAPHRAGM and other respiratory muscles.Receptors, Dopamine D2: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)Hypoglossal Nerve: The 12th cranial nerve. The hypoglossal nerve originates in the hypoglossal nucleus of the medulla and supplies motor innervation to all of the muscles of the tongue except the palatoglossus (which is supplied by the vagus). This nerve also contains proprioceptive afferents from the tongue muscles.Respiratory Muscles: These include the muscles of the DIAPHRAGM and the INTERCOSTAL MUSCLES.Respiratory Physiological Processes: Biological actions and events that support the functions of the RESPIRATORY SYSTEM.Respiratory Mechanics: The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.Receptors, Dopamine D1: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D1-class receptor genes lack INTRONS, and the receptors stimulate ADENYLYL CYCLASES.Dopamine Agonists: Drugs that bind to and activate dopamine receptors.Respiratory Paralysis: Complete or severe weakness of the muscles of respiration. This condition may be associated with MOTOR NEURON DISEASES; PERIPHERAL NERVE DISEASES; NEUROMUSCULAR JUNCTION DISEASES; SPINAL CORD DISEASES; injury to the PHRENIC NERVE; and other disorders.Dopamine Antagonists: Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.Receptors, Dopamine: Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.Brain Stem: The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.Respiration: The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).Survival of Motor Neuron 1 Protein: A SMN complex protein that is essential for the function of the SMN protein complex. In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD.Receptors, Dopamine D3: A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Neurons, Afferent: Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.Cell Death: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.Diaphragm: The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.Motor Cortex: Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex.Survival of Motor Neuron 2 Protein: A SMN complex protein that is closely-related to SURVIVAL OF MOTOR NEURON 1 PROTEIN. In humans, the protein is encoded by an often duplicated gene found near the inversion centromere of a large inverted region of CHROMOSOME 5.Dopamine Plasma Membrane Transport Proteins: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.Evoked Potentials, Motor: The electrical response evoked in a muscle or motor nerve by electrical or magnetic stimulation. Common methods of stimulation are by transcranial electrical and TRANSCRANIAL MAGNETIC STIMULATION. It is often used for monitoring during neurosurgery.Medulla Oblongata: The lower portion of the BRAIN STEM. It is inferior to the PONS and anterior to the CEREBELLUM. Medulla oblongata serves as a relay station between the brain and the spinal cord, and contains centers for regulating respiratory, vasomotor, cardiac, and reflex activities.Vagotomy: The interruption or removal of any part of the vagus (10th cranial) nerve. Vagotomy may be performed for research or for therapeutic purposes.Dopamine Agents: Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.Respiratory Physiological Phenomena: Physiological processes and properties of the RESPIRATORY SYSTEM as a whole or of any of its parts.Respiratory System: The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Motor Activity: The physical activity of a human or an animal as a behavioral phenomenon.Hypocapnia: Clinical manifestation consisting of a deficiency of carbon dioxide in arterial blood.Periodicity: The tendency of a phenomenon to recur at regular intervals; in biological systems, the recurrence of certain activities (including hormonal, cellular, neural) may be annual, seasonal, monthly, daily, or more frequently (ultradian).Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.Anoxia: Relatively complete absence of oxygen in one or more tissues.Inhalation: The act of BREATHING in.Electromyography: Recording of the changes in electric potential of muscle by means of surface or needle electrodes.Cause of Death: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.Muscular Atrophy, Spinal: A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)Electric Stimulation: Use of electric potential or currents to elicit biological responses.Neuronal Plasticity: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.Receptors, Dopamine D5: A subtype of dopamine D1 receptors that has higher affinity for DOPAMINE and differentially couples to GTP-BINDING PROTEINS.Tidal Volume: The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.Dopamine Uptake Inhibitors: Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.Corpus Striatum: Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.Pulmonary Ventilation: The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.Axons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Nerve Tissue ProteinsChemoreceptor Cells: Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.Action Potentials: Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.Animals, Newborn: Refers to animals in the period of time just after birth.Dopaminergic Neurons: Neurons whose primary neurotransmitter is DOPAMINE.SMN Complex Proteins: A complex of proteins that assemble the SNRNP CORE PROTEINS into a core structure that surrounds a highly conserved RNA sequence found in SMALL NUCLEAR RNA. They are found localized in the GEMINI OF COILED BODIES and in the CYTOPLASM. The SMN complex is named after the Survival of Motor Neuron Complex Protein 1, which is a critical component of the complex.Dopamine beta-HydroxylaseFunctional Laterality: Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Cervical Vertebrae: The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.Synaptic Transmission: The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Molecular Motor Proteins: Proteins that are involved in or cause CELL MOVEMENT such as the rotary structures (flagellar motor) or the structures whose movement is directed along cytoskeletal filaments (MYOSIN; KINESIN; and DYNEIN motor families).Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Carbon Dioxide: A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.Ganglia, Invertebrate: Clusters of neuronal cell bodies in invertebrates. Invertebrate ganglia may also contain neuronal processes and non-neuronal supporting cells. Many invertebrate ganglia are favorable subjects for research because they have small numbers of functional neuronal types which can be identified from one animal to another.Quinpirole: A dopamine D2/D3 receptor agonist.Behavior, Animal: The observable response an animal makes to any situation.Synapses: Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.Tyrosine 3-Monooxygenase: An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 184.108.40.206.Neuromuscular Diseases: A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manifestations include MUSCLE WEAKNESS; FASCICULATION; muscle ATROPHY; SPASM; MYOKYMIA; MUSCLE HYPERTONIA, myalgias, and MUSCLE HYPOTONIA.Death: Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.Mesencephalon: The middle of the three primitive cerebral vesicles of the embryonic brain. Without further subdivision, midbrain develops into a short, constricted portion connecting the PONS and the DIENCEPHALON. Midbrain contains two major parts, the dorsal TECTUM MESENCEPHALI and the ventral TEGMENTUM MESENCEPHALI, housing components of auditory, visual, and other sensorimoter systems.Interneurons: Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.Benzazepines: Compounds with BENZENE fused to AZEPINES.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Substantia Nigra: The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Cholinergic Neurons: Neurons whose primary neurotransmitter is ACETYLCHOLINE.Nucleus Accumbens: Collection of pleomorphic cells in the caudal part of the anterior horn of the LATERAL VENTRICLE, in the region of the OLFACTORY TUBERCLE, lying between the head of the CAUDATE NUCLEUS and the ANTERIOR PERFORATED SUBSTANCE. It is part of the so-called VENTRAL STRIATUM, a composite structure considered part of the BASAL GANGLIA.Movement: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.Neural Inhibition: The function of opposing or restraining the excitation of neurons or their target excitable cells.Patch-Clamp Techniques: An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.Neostriatum: The phylogenetically newer part of the CORPUS STRIATUM consisting of the CAUDATE NUCLEUS and PUTAMEN. It is often called simply the striatum.Dendrites: Extensions of the nerve cell body. They are short and branched and receive stimuli from other NEURONS.Aplysia: An opisthobranch mollusk of the order Anaspidea. It is used frequently in studies of nervous system development because of its large identifiable neurons. Aplysiatoxin and its derivatives are not biosynthesized by Aplysia, but acquired by ingestion of Lyngbya (seaweed) species.Superoxide Dismutase: An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 220.127.116.11.Raclopride: A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.Models, Neurological: Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Cerebral Cortex: The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.Mice, Inbred C57BLGABAergic Neurons: Neurons whose primary neurotransmitter is GAMMA-AMINOBUTYRIC ACID.gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Anterior Horn Cells: MOTOR NEURONS in the anterior (ventral) horn of the SPINAL CORD which project to SKELETAL MUSCLES.Neuromuscular Junction: The synapse between a neuron and a muscle.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Sensory Receptor Cells: Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.Respiration, Artificial: Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).Ganglia, Spinal: Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.Hippocampus: A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)Apomorphine: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)Bulbar Palsy, Progressive: A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)Ventral Tegmental Area: A region in the MESENCEPHALON which is dorsomedial to the SUBSTANTIA NIGRA and ventral to the RED NUCLEUS. The mesocortical and mesolimbic dopaminergic systems originate here, including an important projection to the NUCLEUS ACCUMBENS. Overactivity of the cells in this area has been suspected to contribute to the positive symptoms of SCHIZOPHRENIA.Locomotion: Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Animals, Genetically Modified: ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.Neuropeptides: Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Salicylamides: Amides of salicylic acid.Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.Motor Skills Disorders: Marked impairments in the development of motor coordination such that the impairment interferes with activities of daily living. (From DSM-V)Facial Nerve: The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and SALIVARY GLANDS, and convey afferent information for TASTE from the anterior two-thirds of the TONGUE and for TOUCH from the EXTERNAL EAR.Reaction Time: The time from the onset of a stimulus until a response is observed.Cell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Excitatory Postsynaptic Potentials: Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS.Green Fluorescent Proteins: Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.Homovanillic AcidNerve Net: A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.Axonal Transport: The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)Central Nervous System: The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.Microdialysis: A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.Choline O-Acetyltransferase: An enzyme that catalyzes the formation of acetylcholine from acetyl-CoA and choline. EC 18.104.22.168.Ganglia: Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM.Neural Conduction: The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.Evoked Potentials: Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.Psychomotor Performance: The coordination of a sensory or ideational (cognitive) process and a motor activity.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Neurotransmitter Agents: Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.Neurons, Efferent: Neurons which send impulses peripherally to activate muscles or secretory cells.Neurofilament Proteins: Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)Grasshoppers: Plant-eating orthopterans having hindlegs adapted for jumping. There are two main families: Acrididae and Romaleidae. Some of the more common genera are: Melanoplus, the most common grasshopper; Conocephalus, the eastern meadow grasshopper; and Pterophylla, the true katydid.Neural Pathways: Neural tracts connecting one part of the nervous system with another.Dopamine and cAMP-Regulated Phosphoprotein 32: A phosphoprotein that was initially identified as a major target of DOPAMINE activated ADENYLYL CYCLASE in the CORPUS STRIATUM. It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE.Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.Presynaptic Terminals: The distal terminations of axons which are specialized for the release of neurotransmitters. Also included are varicosities along the course of axons which have similar specializations and also release transmitters. Presynaptic terminals in both the central and peripheral nervous systems are included.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Cerebellum: The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.Afferent Pathways: Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.Olfactory Receptor Neurons: Neurons in the OLFACTORY EPITHELIUM with proteins (RECEPTORS, ODORANT) that bind, and thus detect, odorants. These neurons send their DENDRITES to the surface of the epithelium with the odorant receptors residing in the apical non-motile cilia. Their unmyelinated AXONS synapse in the OLFACTORY BULB of the BRAIN.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Nerve Growth Factors: Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.Caudate Nucleus: Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain.Neuroglia: The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.Pyramidal Cells: Projection neurons in the CEREBRAL CORTEX and the HIPPOCAMPUS. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region.Chick Embryo: The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.Cyclic AMP Response Element-Binding Protein: A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.Ergolines: A series of structurally-related alkaloids that contain the ergoline backbone structure.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Astrocytes: A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.Neurogenesis: Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.Leeches: Annelids of the class Hirudinea. Some species, the bloodsuckers, may become temporarily parasitic upon animals, including man. Medicinal leeches (HIRUDO MEDICINALIS) have been used therapeutically for drawing blood since ancient times.Macaca mulatta: A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.Reward: An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)Basal Ganglia: Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres.Muscles: Contractile tissue that produces movement in animals.Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Receptors, N-Methyl-D-Aspartate: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.Rhombencephalon: The posterior of the three primitive cerebral vesicles of an embryonic brain. It consists of myelencephalon, metencephalon, and isthmus rhombencephali from which develop the major BRAIN STEM components, such as MEDULLA OBLONGATA from the myelencephalon, CEREBELLUM and PONS from the metencephalon, with the expanded cavity forming the FOURTH VENTRICLE.Physical Stimulation: Act of eliciting a response from a person or organism through physical contact.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Paralysis: A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)Neurotoxins: Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.Prefrontal Cortex: The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin.Neurites: In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.Spinal Muscular Atrophies of Childhood: A group of recessively inherited diseases that feature progressive muscular atrophy and hypotonia. They are classified as type I (Werdnig-Hoffman disease), type II (intermediate form), and type III (Kugelberg-Welander disease). Type I is fatal in infancy, type II has a late infantile onset and is associated with survival into the second or third decade. Type III has its onset in childhood, and is slowly progressive. (J Med Genet 1996 Apr:33(4):281-3)Caenorhabditis elegans: A species of nematode that is widely used in biological, biochemical, and genetic studies.Neuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.FMRFamide: A molluscan neuroactive peptide which induces a fast excitatory depolarizing response due to direct activation of amiloride-sensitive SODIUM CHANNELS. (From Nature 1995; 378(6558): 730-3)Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Putamen: The largest and most lateral of the BASAL GANGLIA lying between the lateral medullary lamina of the GLOBUS PALLIDUS and the EXTERNAL CAPSULE. It is part of the neostriatum and forms part of the LENTIFORM NUCLEUS along with the GLOBUS PALLIDUS.Excitatory Amino Acid Antagonists: Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Axotomy: Transection or severing of an axon. This type of denervation is used often in experimental studies on neuronal physiology and neuronal death or survival, toward an understanding of nervous system disease.Nervous System: The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)Peripheral Nerves: The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Nerve Regeneration: Renewal or physiological repair of damaged nerve tissue.Homeodomain Proteins: Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
Ethanol's rewarding and reinforcing (i.e., addictive) properties are mediated through its effects on dopamine neurons in the ... At very high concentrations, markedly decreased heart rate, respiratory depression, and death can result due to profound ... impaired sensory and motor function, slowed cognition, stupefaction, unconsciousness, and possible death. Ethanol is commonly ... These factors promote tissue inflammation and contribute to organ pathology. Ethanol-containing beverages can cause urticarial ...
... pre-existing respiratory depression, marked neuromuscular respiratory, acute pulmonary insufficiency, chronic psychosis, ... Giardino, L.; Zanni, M.; Pozza, M.; Bettelli, C.; Covelli, V. (5 March 1998). "Dopamine receptors in the striatum of rats ... Fainting Hypotension (low blood pressure) Hypoventilation (shallow breathing) Impaired motor functions Dizziness Impaired ... of GABAergic neurons. Long-term use causes adaptive changes in the benzodiazepine receptors, making them less sensitive to ...
... of neurons in the ventral portion of the midbrain that uses dopamine as its neurotransmitter and is involved in both motor ... The pons houses the respiratory pneumotaxic center and apneustic center that make up the pontine respiratory group in the ... Criteria for claiming brainstem death in the UK have developed in order to make the decision of when to stop ventilation of ... These determining factors are that the patient is irreversibly unconscious and incapable of breathing unaided. All other ...
Dopamine kills dopamine-producing neurons by interfering with the electron transport chain in neurons. This interference ... Investigations into anatoxin-a, also known as "Very Fast Death Factor", began in 1961 following the deaths of cows that drank ... This is a result of TeNT migration through motor neurons to the inhibitory neurons of the spinal cord after entering through ... convulsions and rapid death by respiratory paralysis. The nerve tissues which communicate with muscles contain a receptor ...
Management of Parkinson's disease
L-DOPA is transformed into dopamine in the dopaminergic neurons by dopa-decarboxylase. Since motor symptoms are produced by a ... is based on the idea that certain neurons that produce dopamine and are susceptible to premature degeneration and cell death ... This may be due to the distribution factor; the trophic factor was not distributed sufficiently throughout the target place. ... Also, due to the forward flexed posture and respiratory dysfunctions in advanced Parkinson's disease, deep diaphragmatic ...
All of these, except elemental liquid mercury produce toxicity or death with less than a gram. Mercury's zero oxidation state ( ... Prefrontal cortex or dopamine neurotransmission could be especially sensitive to even subtle gestational methylmercury exposure ... Currently there is no accepted scientific evidence that exposure to thiomersal is a factor in causing autism. Dental amalgam is ... In humans, approximately 80% of inhaled mercury vapor is absorbed via the respiratory tract, where it enters the circulatory ...
The motor symptoms of PD are the result of reduced dopamine production in the brain's basal ganglia. Dopamine does not cross ... in many of the remaining neurons. This loss of neurons is accompanied by the death of astrocytes (star-shaped glial cells) and ... Many risk factors and protective factors have been proposed, sometimes in relation to theories concerning possible mechanisms ... Also, due to the forward flexed posture, and respiratory dysfunctions in advanced Parkinson's disease, deep diaphragmatic ...
Epigenetics of neurodegenerative diseases
Specifically, over time, decreased levels of SMN protein results in gradual death of the alpha motor neurons in the anterior ... Epigenetic factors. ncRNA. Reductions of miR-133b correlated to decreased numbers of dopaminergic neurons in the midbrain ... control of eye muscles and often die of respiratory failure or pneumonia as a result of degeneration of the motor neurons and ... "A MicroRNA feedback circuit in midbrain dopamine neurons". primary. Science. 317 (5842): 1220-4. Bibcode:2007Sci...317.1220K. ...
... in dopaminergic neurons in the substantia nigra and contributes to optimal functioning of the basal ganglia involved in motor ... Other factors, such as JUNB and SIRT1, that maintain skeletal muscle mass and promote hypertrophy are also induced with regular ... Studies have shown that since heart disease is the leading cause of death in women, regular exercise in aging women leads to ... One sign of Overtraining Syndrome (OTS) is suppressed immune function, with an increased incidence of upper respiratory tract ...
In vitro spinal cord cultures with glutamate transport inhibitors led to degeneration of motor neurons, which was counteracted ... "Glutamate receptor GluR3 antibodies and death of cortical cells". Neuron. 20 (1): 153-63. doi:10.1016/S0896-6273(00)80443-2. ... Maren S, Tocco G, Standley S, Baudry M, Thompson RF (1993). "Postsynaptic factors in the expression of long-term potentiation ( ... Nicholls DG (December 2009). "Spare respiratory capacity, oxidative stress and excitotoxicity". Biochem. Soc. Trans. 37 (Pt 6 ...
... dopamine, and gamma-aminobutyric acid (GABA). Other neurotransmitters and peptides, such as corticotropin-releasing factor, may ... Lähmender Stillstand und Motor des Fortschritts. Stauffenburg, Tübingen 2012, pp. 49-54 ... Anxiety processing in the basolateral amygdala has been implicated with dendritic arborization of the amygdaloid neurons. SK2 ... The Lancet Respiratory Medicine. 4 (11): 911-924. doi:10.1016/S2213-2600(16)00097-7. PMID 27264777.. ...
Effects of cannabis
According to the Merck Index, the LD50 of THC (the dose which causes the death of 50% of individuals) is 1270 mg/kg for ... A confounding factor in cannabis research is the prevalent usage of other recreational drugs, especially alcohol and nicotine.[ ... This agonism of the cannabinoid receptors results in changes in the levels of various neurotransmitters, especially dopamine ... Other functions such as reaction time, attention, language, reasoning ability, perceptual and motor skills were unaffected. The ...
... by antagonizing A1 receptors in the axon terminal of dopamine neurons and A1-A2A heterodimers (a receptor complex composed of 1 ... chronic caffeine exposure counteracts both motor activation and dopamine release in the nucleus accumbens induced by caffeine ... Peters JM (1967). "Factors Affecting Caffeine Toxicity: A Review of the Literature". The Journal of Clinical Pharmacology and ... Massive overdose can result in death. The LD50 of caffeine in humans is dependent on individual sensitivity, but is estimated ...
May 2007). "Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons". Nature ... It results from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of cell- ... are normal byproducts of mitochondrial respiratory chain activity. ROS concentration is mediated by mitochondrial antioxidants ... Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons. Many ...
... programmed cell death), promoting tumor growth, and activating growth factors and cellular mitogenic factors such as 5- ... A Position Statement of the Forum of International Respiratory Societies". American Journal of Respiratory and Critical Care ... dopamine, and beta-endorphin in parts of the brain. Nicotine also extends the duration of positive effects of dopamine and ... Nicotine has clinically significant cognitive-enhancing effects at low doses, particularly in fine motor skills, attention, and ...
... pre-existing respiratory depression, marked neuromuscular respiratory, acute pulmonary insufficiency, chronic psychosis, ... Factors that determine the risk of psychological dependence or physical dependence and the severity of the benzodiazepine ... Giardino L, Zanni M, Pozza M, Bettelli C, Covelli V (March 1998). "Dopamine receptors in the striatum of rats exposed to ... Sedative drugs, including alprazolam, have been associated with an increased risk of death. ...
Prenatal cocaine exposure
PCE may also interfere with the way the motor system matures. Motor effects that have been documented include poorer reflexes ... and PCE does not present much risk beyond these risk factors. PCE is clustered with other risk factors to the child, such as ... Early reports found that cocaine-exposed babies were at high risk for sudden infant death syndrome; however, by itself, cocaine ... The most important way cocaine affects fetal development is by binding to dopamine receptors. Another possible mechanism by ...
Effects of cannabis
According to the Merck Index, the LD50 of THC (the dose which causes the death of 50% of individuals) is 1270 mg/kg for male ... A confounding factor in cannabis research is the prevalent usage of other recreational drugs, especially alcohol and nicotine. ... This agonism of the cannabinoid receptors results in changes in the levels of various neurotransmitters, especially dopamine ... Cannabinoids produce a "marked depression of motor activity" via activation of neuronal cannabinoid receptors belonging to the ...
... leading to respiratory arrest and death. Diazepam in doses of 5 mg or more causes significant deterioration in alertness ... A single dose of diazepam modulates the dopamine system in similar ways to how morphine and alcohol modulate the dopaminergic ... Benzodiazepines: Diazepam is the most common benzodiazepine used in dogs and cats to reduce motor activity and permit placement ... This increased chloride ion influx hyperpolarizes the neuron's membrane potential. As a result, the difference between resting ...
... or dopamine) in the cytosol of a monoamine neuron. Activation of TAAR1 by MDMA triggers protein kinase A and protein ... and impaired motor functioning. Motor delays may be temporary during infancy or long-term. The severity of these developmental ... "Dr Death"), which is much more toxic than MDMA and can cause overheating, muscle spasms, seizures, unconsciousness, and death. ... Depression is one of the main factors for cessation of use. ... Acute respiratory distress syndrome. Urinary *Acute kidney ...
Selective serotonin reuptake inhibitor
There was no statistically significant effect on death, motor deficits, or cognition. SSRIs are effective for the treatment of ... Treatment with SSRIs has shown reduced production of inflammatory cytokines such as IL-1β, tumor necrosis factor (TNF)-α, IL-6 ... On chronic dosing, the increased occupancy of post-synaptic serotonin receptors signals the pre-synaptic neuron to synthesize ... endocrine and/or respiratory symptoms among a large minority of infants with intrauterine exposure. These syndromes are short- ...
"Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons". Nature Neuroscience. 10 (5 ... It results from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of cell- ... are normal byproducts of mitochondrial respiratory chain activity. ROS concentration is mediated by mitochondrial antioxidants ... Programmed cell death. Programmed cell death (PCD) is death of a cell in any form, mediated by an intracellular program.[ ...
... and other morphological changes appear to indicate a long term damage of dopamine neurons. All these effects contribute a rise ... Red line represents the number of cocaine deaths that also involved opioids, and the purple line represents cocaine deaths that ... Hope BT (May 1998). "Cocaine and the AP-1 transcription factor complex". Annals of the New York Academy of Sciences. 844: 1-6. ... Cocaine use leads to increases in alertness, feelings of well-being and euphoria, increased energy and motor activity, and ...
List of syndromes
... syndrome Ulysses syndrome Uncombable hair syndrome Uner Tan syndrome Upper airway resistance syndrome Upper motor neuron ... pneumonitis Acute motor axonal neuropathy acute platelete activation syndrome Acute radiation syndrome Acute respiratory ... Stuck song syndrome Student syndrome Sturge-Weber syndrome Subclavian steal syndrome Sudden Death Syndrome Sudden infant death ... obstruction syndrome Distal trisomy 10q Doege-Potter syndrome Donnai-Barrow syndrome Donohue syndrome DOOR syndrome Dopamine ...
Dopamine agonist - levodopa: One of levodopa's chronic side effects that Parkinson's patients experience is the "on-off ... The specific effects of various noble kavas depend on various factors, such as the cultivar used (and the related specific ... Changes in the activity of 5-HT neurons could explain the sleep-inducing action However, failure of the GABAA receptor ... "lest they suffer an untimely death". The reverence for Hiwa in old Hawaiʻi is evident in this portion of a chant recorded by ...
Neuroscience of sleep
115 and both dopamine (DA) and non-DA neurons in the VTA.116, 117. ... In this relation, some studies have shown that after a sequential motor task, the pre-motor and visual cortex areas involved ... This reflex, also known as animal hypnosis or death feigning, functions as the last line of defense against an attacking ... respiratory, cardiac, and movement events were also added. ...
... leading to respiratory arrest and death. Diazepam in doses of 5 mg or more causes significant deterioration in alertness ... Diazepam is the most common benzodiazepine used in dogs and cats to reduce motor activity and permit placement of an IV ... Severe hepatic deficiencies (hepatitis and liver cirrhosis decrease elimination by a factor of two) ... This increased chloride ion influx hyperpolarizes the neuron's membrane potential. As a result, the difference between resting ...
"Neuron. 77 (1): 115-28. doi:10.1016/j.neuron.2012.11.030. PMC 3811118. PMID 23312520.. ... Under optimal growth conditions at 25 °C (77 °F), the D. melanogaster lifespan is about 50 days from egg to death. The ... The limits of respiratory function: external and internal constraints on insect gas exchange. 106 (Pt 3): 189-198. doi:10.1016/ ... Bakker K (1961). "An analysis of factors which determine success in competition for food among larvae of Drosophila ...
The motor symptoms of PD are the result of reduced dopamine production in the brain's basal ganglia. Dopamine does not cross ... in many of the remaining neurons. This loss of neurons is accompanied by the death of astrocytes (star-shaped glial cells) and ... Many risk factors and protective factors have been proposed, sometimes in relation to theories concerning possible mechanisms ... and respiratory dysfunctions in advanced Parkinson's disease, deep diaphragmatic breathing exercises are beneficial in ...
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons | PNAS
... progressive impairment of motor function accompanied by formation of intraneuronal inclusions and dopamine nerve cell death. ... with disruption of the gene for mitochondrial transcription factor A (Tfam) in DA neurons. The knockout mice have reduced mtDNA ... Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Mats I. Ekstrand, Mügen Terzioglu, Dagmar ... Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Mats I. Ekstrand, Mügen Terzioglu, Dagmar ...
Transgenic rodent models of Parkinson's disease | SpringerLink
The nigral dopamine neurons of MitoPark mice show respiratory chain dysfunction, accompanied by the development of ... intraneuronal inclusions and eventual cell death. In early adulthood, the MitoPark mice show a slowly progressing loss of motor ... Manipulation of mitochondrial respiratory genes (e.g. mitochondrial transcription factor A or TFAM) also elicits a PD phenotype ... Progressive Parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci USA 104: 1325-1330PubMed ...
Muhammad Ali Cause Of Death: Septic Shock & Parkinson's Disease-How Did 'The Greatest' Die?
Motor skills deteriorate due to neurons breaking down or dying over time, according to Mayo Clinic. The slow stiffening of ... Parkinsons develops when cells that produce the neurotransmitter dopamine begin dying. Dopamine is what transports signals to ... These factors can put a patient at risk of developing pneumonia.. "While Muhammad Ali is best known as one of the greatest ... Ali family spokesperson, Bob Gunnell reported Muhammad was rushed to the hospital on Friday due to a "respiratory problem." The ...
Molecular and Cellular Transitions from ES Cells to Mature Functioning Human Neurons
Indeed, while motor neurons grown on normal astrocytes were fully viable, we saw widespread death of motor neurons in ... These neurons are called dopaminergic because they produce dopamine, a molecule that is necessary for coordinated body movement ... Therapy options are extremely limited and people with ALS usually succumb to respiratory failure or pneumonia within three to ... We found that the Nurr1 gene is turned on by inflammatory signals and suppresses genes that encode neurotoxic factors. ...
Molecular and Cellular Transitions from ES Cells to Mature Functioning Human Neurons | California's Stem Cell Agency
Indeed, while motor neurons grown on normal astrocytes were fully viable, we saw widespread death of motor neurons in ... These neurons are called dopaminergic because they produce dopamine, a molecule that is necessary for coordinated body movement ... Efficient Generation of Functional Motor Neurons From Human Pluripotent Stem Cells Using Gene Delivered Transcription Factor ... Therapy options are extremely limited and people with ALS usually succumb to respiratory failure or pneumonia within three to ...
Mercury & Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease) - DAMS - Dental Amalgam Mercury Solutions
ALS is not a unique disease with a single cause or factor, but instead it is a result of damage to motor neurons and the motor ... Mechanisms of dopamine-induced cell death and differences from glutamate induced cell death. Exp Neurol. 1997; 143(2): 269-81. ... pathological ALS skeletal muscles related to changes of mitochondrial respiratory chain which appears to affect motor neuron ... ALS is a systemic motor neuron disease that affects the corticospinal and corticobulbar tracts, ventral horn motor neurons, and ...
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... of the total number of neurons in the brain. This low amount of neurons regulates important brain functions such as motor ... Although HD striatal neurons had similar respiratory capacity as those from their wild-type littermates when they were ... mtPTP opening is triggered by matrix Ca2+ but its activity can be modulated by several other factors such as oxidative stress, ... The extent of MPTP-induced lesioning is measured by HPLC analysis of dopamine and its metabolites and semi-quantitative Western ...
Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice
... motor neuron-specific SOD2-knockout mice showed the loss of SOD2 expression specifically in a subset of somatomotor neurons and ... because these neurons contain reactive quinone, which is converted from intrinsic dopamine through autooxidation [26, 27]. ... Figure 4: Impaired mitochondrial respiratory activities. Enzymatic histochemical staining for NADHD (top panels) (a, b), SDH ( ... Astrocytes have more potent defense systems against oxidative stress, including NF-E2-related factor 2- (Nrf2-) antioxidant ...
Marijuana Compounds: A Nonconventional Approach to Parkinson's Disease Therapy
... the nigrostriatal dopamine neurons. The current treatment is symptomatic and mainly involves replacement of dopamine deficiency ... R. Pahwa, S. A. Factor, K. E. Lyons et al., "Practice parameter: Treatment of Parkinson disease with motor fluctuations and ... J. Xu, K. D. Kochanek, and S. L. Murphy, "National vital statistics reports deaths: final data for 2007," Statistics, vol. 58, ... respiratory illness, and decline in cognitive processing. Cannabis use has been indicated as a potential cause, aggravator, or ...
Journal of NeuroImmune Pharmacology
Gene-environment complex interaction leads to selective dopaminergic neuron death in PD. G rowing evidences supports that ... JNIP Impact Factor Rise Is a Final Tribute to the Years of Impactful Service Made by our Managing Editor. (Source: Journal of ... that is then selectively transported into nigral neurons via the mesencephalic dopamine transporte.... Source: Journal of ... AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 ( ...
798 | Parkinson's Disease | Anxiety Disorder
Bowel movement frequency in late-life and substantia nigra neuron density at death. Acta Psychiatr Scand. Acta Neuropathol. ... Longevity has substantially improved with dopamine replacement therapy1; however, advanced-stage PD motor symptoms respond ... factors may surface and disappear at any time during the patients lives; however, some component causative factor(s) must be ... Respiratory chain abnormalities in skeletal muscle from patients with Parkinsons disease. Mov Disord. de Vos RAI. 17. Acta ...
Genes | Free Full-Text | Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson's Disease? | HTML
Dopaminergic neurons, for their intrinsic characteristics, have a high energy demand that relies on the efficiency of the ... mitochondria respiratory chain. Dysregulations of mitochondria, deriving from alterations of complex I protein or oxidative DNA ... is a movement disorder characterized by dopaminergic nigrostriatal neuron degeneration and the formation of Lewy bodies (LB), ... multiple factors, such as broad spikes, pacemaking, low intrinsic Ca2+ buffering, cytosolic Ca2+ oscillations and dopamine ...
ALZFORUM | NETWORKING FOR A CURE
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4 ... They have shown motor deficits, which respond to L-dopa therapy. The progressive development of the loss of midbrain neurons ... The increase in deletions in these neurons is sufficient to cause cell death in other circumstances. The present findings, ... on mitochondrial transcription factor A (Tfam) promoter. Biochem Biophys Res Commun. 2006 Jun 9;344(3):708-12. PubMed. ...
IJMS | Free Full-Text | Mechanisms of Oxidative Damage in Multiple Sclerosis and Neurodegenerative Diseases: Therapeutic...
In EAE, DMF ameliorates the disease course and improves preservation of myelin, axons and neurons. Finally, Nrf2 is also up- ... related factor 2 (Nrf2). Thus, novel therapeutics enhancing cellular resistance to free radicals could prove useful for MS ... particularly involving the transcription factor nuclear factor (erythroid-derived 2)- ... Cleveland, D.W.; Rothstein, J.D. From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS. Nat. Rev. ...
Protocols and Video Articles Authored by Brandon K. Harvey (Translated to Portuguese)
Ameliorates Motor Symptoms Without Slowing Neurodegeneration in Mice with Respiratory Chain-deficient Dopamine Neurons Cell ... which belongs to the evolutionarily conserved CDNF/MANF family of neurotrophic factors. The degeneration of dopamine neurons ... Repeated administration of high doses of methamphetamine induces programmed cell death, suppression of dopamine release, and ... Degeneration of midbrain dopamine neurons causes the striatal dopamine deficiency responsible for the hallmark motor symptoms ...
New Mouse Model Links Mitochondria to Parkinson Disease | ALZFORUM
Paper: Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. This is a very interesting paper. It ... They have shown motor deficits, which respond to L-dopa therapy. The progressive development of the loss of midbrain neurons ... The increase in deletions in these neurons is sufficient to cause cell death in other circumstances. The present findings, ... First author Mats Ekstrand and colleagues trained the system on the gene for mitochondrial transcription factor A (Tfam). Tfam ...
Genetics of Parkinson's disease and related disorders | Journal of Medical Genetics
The loss of dopamine in the SNc impairs disinhibition, preventing the stimulation of the motor cortex. The early prominent ... Regarding selective cell death, around disease onset, patients with PD already show loss of 10%-20% of DA neurons consistent ... Thus, cell autonomous factors appear to modulate the vulnerability of neurons within the PD network. Recent work proposes that ... These toxins interfere with the respiratory chain and cause oxidative stress that ultimately kills DA neurons with such ...
Study Points - Course #98770: Parkinson Disease - NetCE
Dopamine neuron loss is most prominent in the ventral lateral substantia nigra; 60% to 80% of these neurons are lost when motor ... The mode of death often involves respiratory compromise from bronchopneumonia or aspiration . ... Both factors may develop from a single epiphenomenon, such as neurodegeneration. Evidence also suggests contribution to PD ... 3 . In patients with PD, motor features begin appearing when what proportion of substantia nigra dopamine neurons are lost?. A) ...
HYPOXIC ENCEPHALOPATHY SECONDARY TO STATUS EPILEPTICUS SECONDARY TO CENTRAL NERVOUS SYSTEM INFECTION | Neuron | Cerebrum
Commonly causative factors for respiratory infections, H. influenzae and S. pneumoniae may cause CNS infection by infiltrating ... Motor neurons and somatic neurons are all excitatory neurons. Excitatory neurons in the brain are often glutamatergic. Spinal ... Modulatory neurons evoke more complex effects termed neuromodulation. These neurons use such neurotransmitters as dopamine, ... Severe cases of malnutrition can lead to death. of 3 feet 2 inches summing up to a total BMI of 11.3 suggesting that the child ...
Neurological Effects of Mercury Exposure - DAMS - Dental Amalgam Mercury Solutions
Therapeutic applications of neurotrophic factors in disorders of motor neurons and peripheral nerves. Mol Med Today. 1995; 1(6 ... Mechanisms of dopamine-induced cell death and differences from glutamate induced cell death. Exp Neurol. 1997; 143(2): 269-81. ... Antibiotic resistance in oral/respiratory bacteria. Crit Rev Oral Biol Med. 1998; 9 (4): 522. ... but males have been found more responsive to this factor than women. IGF-I controls the survival of spinal motor neurons ...
Frontiers | Neurochemical Alterations in Sudden Unexplained Perinatal Deaths-A Review | Pediatrics
The purpose of this study is to investigate factors behind failure in control of these unexplanined deaths and how research may ... The purpose of this study is to investigate factors behind failure in control of these unexplanined deaths and how research may ... Sudden infant death syndrome (SIDS) is unexpected and mysterious death of an apparently healthy neonate from birth till one ... Stillbirth is defined as death of a fetus after 20th week of gestation or just before delivery at full term without a known ...
Frontiers | Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on...
... environmental chemicals can have an array of adverse effects resulting in cell death, such as aberrant redox cycling and ... environmental chemicals can have an array of adverse effects resulting in cell death, such as aberrant redox cycling and ... that leads to the subsequent loss of dopaminergic neurons and dopamine production over time. While risk factors for the disease ... respiratory paralysis, and death (Gosselin et al., 1984). To investigate the potential relationship between maneb and PD, ...
Insight into a neuron's preferential susceptibility to oxidative stress | Biochemical Society Transactions
... in HD by a loss of striatal medium-sized spiny neurons, and in MND by the death of upper and lower motor neurons. In contrast ... as numerous transcription factors are redox-sensitive, including NF-κB (nuclear factor κB), HIF (hypoxia-inducible factor), AP- ... but also to the metabolism or auto-oxidation of dopamine itself, as this produces peroxide and superoxide respectively [6,8]. ... and is evident pathologically by respiratory chain dysfunction, decreased ATP production, Ca2+ dysregulation and alterations in ...
Neuro- Degenerative Flashcards by Andrew Green | Brainscape
Most common motor neuron disorder. • Progressive, short duration. • Middle-age male (twice the risk). • Death in 2-5 years. o ... Death in 2-5 years. o Normally respiratory failure. • Muscle atrophy (no stim, no use), weakness, fasciculations. • Dysarthria ... NOTE- proteins called lewy bodies are seen on the dopamine neurons, we are not sure why ... and environmental factors ... o Motor nucleus in brain stem. o Upper motor Neurons (UMN) in ...
Environmental Factor: October 2007: Extramural Papers of the Month
This study suggests that loss of locus coeruleus neurons contributes to the motor deficits seen in Parkinsons disease and ... Vascular endothelial growth factor (VEGF) is known to play a critical role in endothelial cell death and angiogenesis. ... Parkinsons disease is a chronic neurodegenerative disease that is characterized by the loss of dopamine-producing neurons in ... Endothelial cell injury is an important factor in predicting the outcome of patients with acute respiratory distress syndrome ( ...
Formation and Signaling Actions of Electrophilic Lipids
Oral administration of the Nrf2 inducer 3H-1,2-dithiole-3-thione (D3T) in a murine model of PD protected neurons from death, ... Nuclear Factor-kappa B. NQO1. NAD(P)H quinone oxidoreductase 1. Nrf2. nuclear factor E2-related factor-2. O2˙−. superoxide ... which constitutes a threat for nigral neuron stability. The auto-oxidation of the endogenous neurotransmitter dopamine will ... The impressive aspect of this study was that there was a very strong correlation between the extent of respiratory inhibition ...
Movement Disorders - Americans for Safe Access
Movement disorders can be chronic disorders which arise from the loss or destruction of neurons and other structures in the ... Parkinsons disease has been linked to dysfunction in the bodys dopamine system, specifically the production of too much of ... Oxidative stress in the brain is a major hallmark of motor and neurological diseases such as Parkinsons and Alzheimers ... Inhaling the smoke of cannabis cigarettes induces side effects on the respiratory system. Cannabinoids are contraindicated for ...
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Cortes CJ et al. Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in ... Zhao H et al. Protective role of nuclear factor erythroid 2-related factor 2 in the hemorrhagic shock-induced inflammatory ... Kumar S et al. The role of tumour suppressor PDCD4 in beta cell death in hypoxia. PLoS One 12:e0181235 (2017). PubMed: 28750063 ... Caì Y et al. CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory ...
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Death of motor neurons may result, leading to muscle atrophy. The motor neurons that survive recover fully and may reinnervate ... Dopamine-containing neurons in the substantia nigra of the ited with the highest intellectual functions. Dopamine is thought to ... NERVE GROWTH FACTOR A substance whose role is to guide LONG-TERM MEMORY The ﬁnal phase of memory in which neuronal growth ... Respiratory failure also shortens the life span of children with SMA2 generic altace 2.5 mg mastercard blood pressure extremely ...
2017; 4(11):336-350 | ss site title
Choi WS, Palmiter RD, Xia Z. Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule ... Cervetto C, Frattaroli D, Maura G, Marcoli M. Motor neuron dysfunction in a mouse model of ALS: gender-dependent effect of P2X7 ... 2.4.5. Quantification of Nuclear Factor kappaB. Nuclear factor kappaB (NF-κB) was measured in supernatants using a commercially ... and evidence of oxidative modification of the respiratory chain complex I have been found in these cases [15, 16, 21‒23]. ...
Parkinson'sStriatal neuronsNigrostriatal dopamineReceptorsToxicityOxidativeDysfunction in DA neuronsSymptomsSerotoninNeurotransmitterFunction in midbrainSubstantia nigra paNeuronalVentralDegenerationEmbryonic stemAcetylcholineReceptorLoss of midbrainLewyStriatumAstrocytesLevels of dopamineMidbrain DA neuronsNigral neuronsAgonistInhibitionSensory neuronsHippocampal neuronsTfamDamage to mitochondriaBrainAutonomicAmyotrophic lateral sNorepinephrineMechanismsSignalsDeficientPeripheralDorsalProteinNeurotransmittersTranscription factorDopaminergic nigrostriatalDeficitsNeurotoxicity inducedVivoSelectiveReflexesPharmacologicalEndogenousFailure
- Studies of human tissues can only generate correlative data, and it is therefore important to experimentally test the hypothesis that mitochondrial dysfunction may be an etiological factor in Parkinson's disease (PD). (pnas.org)
- Muhammad Ali Cause Of Death: Septic Shock & Parkinson's Disease-How Did 'The Greatest' Die? (inquisitr.com)
- Muhammad Ali battled against the neurological illness Parkinson's Disease for more than 30 years before his death, but what did the boxing legend ultimately die from? (inquisitr.com)
- Though the exact cause of the disease is still unknown, Parkinson's develops when cells that produce the neurotransmitter dopamine begin dying. (inquisitr.com)
- This therapy improves only motor symptoms of Parkinson's disease and is associated with a number of adverse effects including dyskinesia. (hindawi.com)
- Parkinson's disease (PD) is a movement disorder characterized by dopaminergic nigrostriatal neuron degeneration and the formation of Lewy bodies (LB), pathological inclusions containing fibrils that are mainly composed of α-synuclein. (mdpi.com)
- Parkinson's disease (PD), the most common neurodegenerative movement disorder, is characterized by a variety of premotor signs, as well as typical motor symptoms, such as resting tremor, rigidity, bradykinesia and postural reflex impairment. (mdpi.com)
- Even in the case of MPTP, a mitochondrial toxin responsible for some rare cases of Parkinson's, it is unclear if the disease directly results from damage to mitochondria in midbrain dopaminergic (DA) neurons that are primarily affected by the disease, or whether other MPTP toxicities or damage to other areas of the brain play a role. (alzforum.org)
- Interestingly, although the brain as a whole is highly vulnerable to OS, the subcellular resistance to OS is heterogeneous, with neurons being a particularly vulnerable brain cell type, as is evident by the AD (Alzheimer's disease), PD (Parkinson's disease), HD (Huntington's disease) and MND (motor neuron disease) pathologies, which are unified by a progressive dysfunction and loss of neurons specifically, as well as by the presence of OS [ 2 ]. (biochemsoctrans.org)
- Parkinson's disease is a chronic neurodegenerative disease that is characterized by the loss of dopamine-producing neurons in the substantia nigra region of the brain. (nih.gov)
- however, MPTP does not cause the motor deficits seen in humans with Parkinson's disease. (nih.gov)
- NIEHS-supported investigators tested mice to determine whether the loss of norepinephrine neurons was necessary for the motor deficits seen in Parkinson's disease. (nih.gov)
- This study suggests that loss of locus coeruleus neurons contributes to the motor deficits seen in Parkinson's disease and implies that administration of norepinephrine-like drugs could have dual therapeutic effects. (nih.gov)
- Parkinson's disease (PD) is a movement disorder caused by the specific loss of dopaminergic neurons in the substantia nigra of the midbrain. (intechopen.com)
- Is Exposure to Air Pollution a Risk Factor for Alzheimer's and Parkinson's Diseases? (unt.edu)
- Parkinson's Disease (PD) is a progressive neurodegenerative disease characterized by neuronal degradation, dopamine (DA) deficiency in the midbrain striatum, and motor dysfunction. (lakeforest.edu)
- Another example of the specificity of the PET technique is the definition of the dopamine system, which is the neural component of the brain affected by Parkinson's disease. (nae.edu)
- The main characteristic features of Parkinson's disease are insufficient formation and activity of dopamine, due to the death of neurons in certain nuclei of the basal ganglia, especially in the substantia nigra. (hpathy.com)
- Symptoms of Parkinson's disease occur when 60% of dopamine containing nerve cells in the substantia nigra becomes impaired. (hpathy.com)
- Advances in our understanding of mechanisms of cell death, plasticity and regeneration in the central nervous system offer new opportunities for remediation and repair in several of the most distressing neurodegenerative diseases of adulthood, in particular Parkinson's and Huntington's disease. (cardiff.ac.uk)
- 2019. Designing stem-cell-based dopamine cell replacement trials for Parkinson's disease . (cardiff.ac.uk)
- Parkinson's disease is a neurodegenerative disorder characterized by a progressive loss of the dopaminergic neurons in the substantia nigra pars compacta. (springer.com)
- Accumulating evidence indicates that apoptosis contributes to the cell death in Parkinson's disease patients' brain. (springer.com)
- The aim: To discover drugs which can stimulate stem cells, resident in the brain and spinal cord, to make new nerves to replace those lost in Head and Spinal cord injury and neurological diseases such Motor Neuron Disease (ALS), Parkinson's, Alzheimer's. (rutgers.edu)
- This discovery marks the turning point in our concept of the brain's self renewing properties and opened up the possibility of harnessing this ability to repair nerve cells lost in Head and Spinal cord injury and in diseases such as Motor Neuron Disease (ALS), Parkinson's, Alzheimer's, Stroke. (rutgers.edu)
- Parkinson's disease (PD) is a neurodegenerative disease, where the reduction of dopamine (DA) in the substantia nigra pars compacta (SNc)-striatal, ventral tegmental area (VTA)-cortex, and VTA-limbic pathways leads to the motor and nonmotor symptoms (NMS) of the disease. (thefreelibrary.com)
- Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is a progressive multiorgan proteinopathy caused by misfolded α-synuclein (α-syn) with variegated motor and nonmotor symptoms owing to a spreading process of synaptic and neuronal loss. (springer.com)
- A class of older medication used to treat Parkinson's disease that works by reducing the amount of acetylcholine in the body and thereby facilitating dopamine cell function. (eu.com)
- A dopamine agonist medication used to treat Parkinson's disease, usually administered by injection. (eu.com)
- Parkinson's disease is a neurodegenerative disorder characterized by the loss of neurons in specific regions of the nervous system, notably in the substantia nigra pars compacta and, in most cases, by the deposition of intraneuronal inclusions named Lewy bodies. (currentprotocols.com)
- Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease. (currentprotocols.com)
- Unified Parkinson's Disease rating Scale (UPDRS) motor score 19/108 on Syndopa, 50/108 off syndopa. (snacc.org)
- Although HD striatal neurons had similar respiratory capacity as those from their wild-type littermates when they were incubated in rich medium containing a supra-physiological glucose concentration (25 mM), pyruvate and amino acids, respiratory defects emerged when cells were incubated in media containing only a physiological cerebral level of glucose (2.5 mM). (jove.com)
- In contrast to glucose, we found no major deficits in HD striatal neurons capacity to use pyruvate as a respiratory substrate compared to wild type littermates. (jove.com)
- Interestingly, the metabolic disturbances observed in striatal neurons were not seen in primary cortical neurons, a brain region affected in later stages of HD. (jove.com)
- However, as in HD, the factors mediating the selective toxicity of 3-NP to striatal neurons are unknown. (jneurosci.org)
- However, the actions of neither glutamate nor NO, alone or in combination, fully explain the sensitivity of striatal neurons to systemically administered 3-NP. (jneurosci.org)
- This suggests that some additional factor mediates the selectivity of the neurotoxic action of 3-NP on striatal neurons. (jneurosci.org)
- Mitochondrial dysfunction is implicated in the pathophysiology of Parkinson′s disease (PD), a common age-associated neurodegenerative disease characterized by intraneuronal inclusions (Lewy bodies) and progressive degeneration of the nigrostriatal dopamine (DA) system. (pnas.org)
- Neurologically, it is characterized by the selective degeneration of a unique population of cells, the nigrostriatal dopamine neurons. (hindawi.com)
- The effect of decreased striatal dopamine on 3-NP toxicity was examined by lesioning the nigrostriatal dopamine input to one striatum 7 d before 3-NP treatment was started. (jneurosci.org)
- Several studies conducted in the past decade have confirmed neuropathological and neurochemical anomalies related to serotonin transporter, substance P, acetylcholine α7 nicotine receptors, etc., in sudden unexplained fetal and infant deaths. (frontiersin.org)
- The investigators hypothesized that ventilation-induced apoptosis in the hippocampus was at least partly mediated by elevated activation of dopamine receptors in that brain area. (medicalxpress.com)
- The investigators then studied the consequences of ventilation and elevated hippocampal dopamine on dysbindin-1, a protein known to affect levels of cell surface D2 dopamine receptors , cognition, and possibly the risk of psychosis. (medicalxpress.com)
- Since the blockade of NMDA receptors in the cerebral cortex enhances the release of dopamine from lower brain regions, reduced glutamate transmission could be the ultimate cause of excessive dopamine activity in the brains of schizophrenic patients. (autismfile.com)
- Dopamine receptors are belong to the family of G protein-coupled receptor. (jcancer.org)
- There are five types of dopamine receptor (DR), including DRD1, DRD2, DRD3, DRD4, and DRD5, which are divided into two major groups: the D1-like receptors (DRD1 and DRD5), and the D2-like receptors (DRD2, DRD3, and DRD4). (jcancer.org)
- Dopamine receptors are involved in all of the physiological functions of dopamine, including the autonomic movement, emotion, hormonal regulation, dopamine-induced immune effects, and tumor behavior, and so on. (jcancer.org)
- Increasing evidence shows that dopamine receptors are associated with the regulation of tumor behavior, such as tumor cell death, proliferation, invasion, and migration. (jcancer.org)
- Recently, some studies showed that dopamine receptors could regulate several ways of death of the tumor cell, including apoptosis, autophagy-induced death, and ferroptosis, which cannot only directly affect tumor behavior, but also limit tumor progress via activating tumor immunity. (jcancer.org)
- This effect was mediated via dopamine receptors because it could be blocked by the administration of dopamine receptor antagonists. (jneurosci.org)
- each neuron can release neurotransmitters and receive them (by means of receptors). (mediologiest.com)
- It is believed that these stimulants cause a physiological change in some neuron receptors, affecting their overall functioning. (mediologiest.com)
- These extracellular fragmented mitochondria can therefore generate sufficient toxicity to trigger neuronal death and widespread brain damage through activation of naïve astrocytes. (medworm.com)
- The researchers were able to reverse the motor effects by supplementation with a norepinephrine precursor and determined that increased levels of norepinephrine protected dopamine-producing neurons from MPTP toxicity. (nih.gov)
- Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Bjorklund A (2013) TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity. (springer.com)
- Unlike amphetamine , it is directly toxic to dopamine neurons, with hyperthermia aggravating its toxicity. (drugs-forum.com)
- In this study we examine the role striatal dopamine plays in 3-NP-induced striatal toxicity. (jneurosci.org)
- The effect of elevated striatal dopamine levels on 3-NP toxicity was examined by using acute administration of methamphetamine. (jneurosci.org)
- Although there are a large number of neuroactive substances in the striatum that might be involved in 3-NP toxicity, one of the best candidates is dopamine. (jneurosci.org)
- Some of the mechanisms of neural damage found in ALS include increased free radical generation/oxidative damage, impaired electron transport, disrupted calcium channel function, reactive astrogliosis and dysfunctional transporters for L-glutamate, neurotoxicity, oxidative damage to mitochondrial DNA/ inhibition of the mitochondrial respiratory chain, autoimmunity, and generalized disruption of metabolism of neuroexciotoxic amino acids like glutamate, aspartate, and NAAG. (amalgam.org)
- The increase in deletions in the human patients may be a consequence of oxidative stress related to dopamine turnover. (alzforum.org)
- Inflammation and oxidative stress are also thought to promote tissue damage in multiple sclerosis (MS). Recent data point at an important role of anti-oxidative pathways for tissue protection in chronic-progressive MS, particularly involving the transcription factor nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2). (mdpi.com)
- The mitochondrial genome encodes 13 key subunits of the respiratory chain (most other mitochondrial genes are actually encoded in the nucleus), and therefore loss of Tfam might be expected to have serious consequences for oxidative respiration. (alzforum.org)
- Environmental and genetic factors induce mitochondrial dysfunction, resulting in abnormal accumulation of miscoded proteins (mostly alpha-synuclein) and generation of oxidative stress in enteric, peripheral, and central nervous systems. (netce.com)
- Within dopaminergic neurons, environmental chemicals can have an array of adverse effects resulting in cell death, such as aberrant redox cycling and oxidative damage, mitochondrial dysfunction, unfolded protein response, ubiquitin-proteome system dysfunction, neuroinflammation, and metabolic disruption. (frontiersin.org)
- Neurons are more vulnerable to oxidative stress than astrocytes, the reasons for which have yet to be fully elucidated. (biochemsoctrans.org)
- Understanding the cellular and molecular mechanisms which contribute to this enhanced vulnerability is key to efforts aimed at ameliorating neuronal health and resilience to oxidative stress, particularly in the context of neurodegenerative disease, which is characterized by progressive dysfunction and loss of neurons specifically, and in which oxidative stress is considered a central aetiological contributor. (biochemsoctrans.org)
- Biological factors which may influence neuronal susceptibility to oxidative stress, in normal and neurodegenerative contexts, are reviewed in the present article, with a focus on properties intrinsic to the neuronal cell type and on properties related to neuronal reliance on surrounding astrocytes. (biochemsoctrans.org)
- One factor with a known capacity to weaken neuronal health is OS (oxidative stress), which arises from an imbalance between oxidant-producing systems and intrinsic antioxidant defences, ultimately resulting in an accumulation of ROS (reactive oxygen species). (biochemsoctrans.org)
- Biochemical markers of oxidative stress: malondialdehyde, reduced glutathione, nitric oxide, paraoxonase-1 (PON-1), and nuclear factor kappaB (NF-kB) were determined in the brain. (aimsci.com)
- The death of the dopaminergic neurons is largely thought to be driven by oxidative/nitrosative stress and neuroinflammation [8, (aimsci.com)
- Overall, the findings clearly demonstrate that BDL induced HE involves mitochondrial respiratory chain dysfunctions, mitochondrial depolarization and swelling that accentuates oxidative stress which in turn leads to compromise in cerebral energy metabolism thereby contributing to the pathophysiology of chronic HE. (springermedizin.de)
- Excitotoxicity, oxidative stress, and mitochondrial respiratory failure are thought to be the key inducers of the apoptotic cascade. (springer.com)
Dysfunction in DA neurons2
- The symptoms of the disease start to appear when there is little dopamine in the body. (inquisitr.com)
- While the causes and symptoms of these two conditions are very different, they share one aspect in common: patients gradually lose specific types of nerve cells, namely the so-called dopaminergic neurons in PD, and motor neurons in ALS. (ca.gov)
- Therapy options are extremely limited and people with ALS usually succumb to respiratory failure or pneumonia within three to five years from the onset of symptoms. (ca.gov)
- Many dopaminergic neurons are already lost when patients develop PD symptoms, which include trembling, stiffness, and slow movement. (ca.gov)
- This paper will demonstrate that mercury is the most common of toxic substances, which are documented to accumulate through chronic exposure in the neurons affected by ALS and which have been documented to cause all of the conditions and symptoms seen in ALS. (amalgam.org)
- In this review we examine the potential benefits of medical marijuana and related compounds in the treatment of both motor and nonmotor symptoms as well as in slowing the progression of the disease. (hindawi.com)
- however, advanced-stage PD motor symptoms respond incompletely to levodopa or related drugs and are now recognized to be caused by nondopaminergic mechanisms.2 Although the dopaminergic nigrostriatal pathway may still hold clues, research on the causes of PD has now extended beyond this system. (scribd.com)
- constipation may precede the motor symptoms of PD by at least 10 and perhaps more than 20 years (Table). (scribd.com)
- For many years, the severity and the duration of motor symptoms in PD has been thought to directly correlate with the rate of neuronal cell loss in the substantia nigra pars compacta (SNpc) [ 6 ]. (mdpi.com)
- In this week's PNAS online, the researchers describe how mitochondrial deficiency in midbrain dopaminergic neurons mimics this devastating disease in mice rather faithfully, with late-onset and slowly progressing neurological symptoms. (alzforum.org)
- The symptoms can be explained by a gradual loss of DA neurons in the dorsolateral striatum beginning around week 12. (alzforum.org)
- Non-motor symptoms preceding and following clinical onset are also helpful diagnostic markers revealing a widespread and progressive pathology. (bmj.com)
- 1 PD is a complex disorder with early non-motor symptoms, core motor symptoms, and late cognitive and psychiatric complications. (bmj.com)
- 2 The core motor symptoms of PD-bradykinesia (slow movements), muscular rigidity, resting tremor, and abnormal posture and gait-were recognised in the original description of the disease 200 years ago by J Parkinson, 3 which JM Charcot later used to define the disease. (bmj.com)
- 2 The main pathology of PD are protein aggregates enriched in α-synuclein (α-syn) called Lewy bodies (LB) that accumulate prominently in dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and in other brain regions that correlate with late symptoms. (bmj.com)
- This disorder is prominently characterized by the motor symptoms of resting tremor, rigidity, and bradykinesia. (netce.com)
- The non-motor features are increasingly identified and include sensory, autonomic, and neuropsychiatric symptoms that appear before motor dysfunction is evident. (netce.com)
- Numerous, potentially disabling non-motor symptoms are often present, and diagnosis is made clinically. (netce.com)
- Improved recognition of both non-motor and motor symptoms can promote early diagnosis and treatment of PD. (netce.com)
- The motor symptoms of PD include tremor, rigidity, slowness of movement, and difficulty with ambulation. (intechopen.com)
- The use of alprazolam during pregnancy is associated with congenital abnormalities, and use in the last trimester may cause fetal drug dependence and withdrawal symptoms in the post-natal period as well as neonatal flaccidity and respiratory problems. (wikipedia.org)
- Interestingly, motor symptoms of PD only begin to show after 60-80% of DA neurons have been lost. (lakeforest.edu)
- For the long pre-symptomatic period, compensatory mechanisms can delay the onset of motor symptoms. (lakeforest.edu)
- The initial motor symptoms typically start insidiously from the distal part of an upper limb and later include other limbs slowly over weeks or months. (hpathy.com)
- 2020. The onset and prevalence of motor and psychiatric symptoms in Huntington's disease . (cardiff.ac.uk)
- Symptoms of botulinum toxin intoxication can progress from difficulty walking, swallowing, and speaking to paralysis of the respiratory muscles and death. (google.com)
- A recent meta-analysis demonstrated that the emergence of NMS (such as memory loss, depression, apathy, and anxiety) often occurs earlier than motor symptoms. (thefreelibrary.com)
- Where fatigue and weakness are the symptoms, the underlying cause of disease may be a failure of motor nerve impulses to cross to the muscle end plate at the neuromuscular junction . (britannica.com)
- Symptoms of motor nerve damage include weakness and muscle atrophy . (britannica.com)
- These pathological alterations have profound effects on the brain function, leading to the progressive development of various symptoms, the most prominent being the impaired initiation of voluntary movements caused by the loss of dopamine signaling in the basal ganglia. (currentprotocols.com)
- affects phenylalanine, serotonin, tyrosine and tryptophan transport to neurons. (amalgam.org)
- The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome. (childrenshospital.org)
- High serum serotonin in sudden infant death syndrome. (childrenshospital.org)
- In addition, their medulla had a drastically reduced number of TH neurons, NE content, and serotonin (5-HT) content. (jneurosci.org)
- Currently, our principal research focus concerns nicotinic receptor systems and their interactions with related transmitter systems such as dopamine, serotonin, norepinepherine, GABA and glutamate. (duke.edu)
- We are concentrating on hippocampal α7 and α4β2 nicotinic receptor subtypes and how they interact with dopamine D1 and D2, serotonin 5HT2, GABA and glutamate NMDA systems with regard to memory, attention and nicotine self-administration. (duke.edu)
- Furthermore, dopamine , norepinephrine and serotonin . (mediologiest.com)
- Mitochondria are the cell's generators, pumping out heat and the high-energy compounds that drive power-hungry processes such as muscle contraction, protein synthesis, and neurotransmitter release-neurons are laden with the tiny organelles. (alzforum.org)
- Glycine is the major inhibitory neurotransmitter in the brain stem and spinal cord, where it participates in a variety of motor and sensory functions. (autismfile.com)
- CB1R are found primarily at the terminals (but also at the axons, cell bodies and dendrites) of central and peripheral neurons, where they typically mediate the inhibition of amino acid and monoamine neurotransmitter release, as occurs with the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) [35- (oatext.com)
- Dopamine is a major catecholamine neurotransmitter, could be synthesized in the central nervous system and mesenteric, such as the digestive tract, spleen and pancreas [ 1 - 3 ]. (jcancer.org)
- Dopamine seems to be the main neurotransmitter related to the problem of dependence, because satisfaction reflexes are no longer normally triggered in the brain by cocaine users. (mediologiest.com)
Function in midbrain1
- It clearly shows that select loss of mitochondrial function in midbrain dopaminergic neurons can lead to a progressive respiratory chain deficiency, which then leads to inclusion formation and loss of dopaminergic neurons. (alzforum.org)
Substantia nigra pa2
- PD is the most common neurodegenerative cause of parkinsonism, a syndrome characterized by progressive deterioration in motor abilities resulting from dopaminergic neuron loss in the substantia nigra pars compacta and ventral tegmental area. (netce.com)
- In PD, the pigmented dopaminergic neurons of the substantia nigra pars compacta (SNPc) of the midbrain undergo selective and continued death. (aimsci.com)
- According to the concept that glucose is not the sole substrate used by the brain for neuronal energy production, we provide evidence that primary neurons can use lactate as well as pyruvate to fuel the mitochondrial respiratory chain. (jove.com)
- According to the theory of neuronal health, neurons exist in a dynamic spectrum of states, which range from highly resilient and fully functional to vulnerable and dysfunctional. (biochemsoctrans.org)
- The present review highlights both intrinsic and extrinsic factors which contribute to neuronal health and importantly a neuron's resultant ability to withstand OS. (biochemsoctrans.org)
- Rotenone caused neuronal atrophy in the cerebral cortex and hippocampus, and decreased the number of pigmented neurons in the substantia nigra. (aimsci.com)
- Although the mechanisms are not yet well defined, it is plausible that neuroprotection results from enhanced neuronal energy reserves, which improve the ability of neurons to resist metabolic challenges, and possibly through other actions including antioxidant and anti-inflammatory effects. (sott.net)
- Using this more fully penetrant model of disease to interrogate brain morphology at the level of electron microscopy, this study shows that dysregulation of fatty acid metabolism via disruption of ACS function in vivo is causal of neurodegenerative pathologies evident in both neuronal cells and their support cell populations, and leads ultimately to lytic cell death in affected areas of the brain. (sdbonline.org)
- Compared to the controls, those on either low- or high-pressure ventilation showed evidence of neuronal cell death in the hippocampus, as a result of a cell suicide program called apoptosis. (medicalxpress.com)
- That trigger is dopamine -induced suppression of a molecule known as Akt, which normally acts to prevent neuronal apoptosis. (medicalxpress.com)
- There is evidence that depletion of reduced glutathione makes neurons more susceptible to excitotoxicity, and that intact mitochondrial function is essential for neuronal resistance to excitotoxic attack. (autismfile.com)
- Many factors in the pathogenesis of PD and the causes of neuronal cell death are still poorly understood. (springer.com)
- There is some later cell loss in the ventral tegmental area, which differs from Parkinson disease and from other models, and presumably if Tfam had been knocked out in other neurons, as well, one might see loss in other brain regions. (alzforum.org)
- It showed adult-onset neurodegeneration, slowly progressive clinical course, earlier onset of cell death, and more extensive cell death in the substantia nigra than the ventral tegmental area, as well as the development of inclusions. (alzforum.org)
- Focusing specifically on the arcuate nucleus in the ventral medulla area of the brainstem -- important in the detection of carbon dioxide and other respiratory and blood pressure responses -- her team is identifying abnormalities that put an infant at risk for sudden death during sleep. (childrenshospital.org)
- The ultimate goals of this research are to define ventral medullary abnormalities in living infants and to suggest ways of preventing the abnormalities from leading to sudden infant death. (childrenshospital.org)
- Her studies have also detected serotonergic binding deficiencies in SIDS victims in six functionally and developmentally related components of ventral medulla--all regions critically involved in chemoreception, respiratory drive, blood pressure responses, upper airway reflexes, and/or thermoregulation. (childrenshospital.org)
- These studies have led to an expanded hypothesis concerning the role of the developing ventral medulla in SIDS: SIDS, or a subset of SIDS, is due to a developmental abnormality in a ventral network composed of rhombic-lip derived, serotonergic neurons, and that this abnormality results in a failure of protective responses to life-threatening challenges (e.g., asphyxia, hypoxia, hypercapnia) during sleep. (childrenshospital.org)
- A key neuropathological hallmark of PD is the progressive loss of nigrostriatal dopaminergic neurons, which is thought to begin from synaptic terminal degeneration [ 1 ]. (mdpi.com)
- Understanding the pathophysiology and genetics of PD and related disorders is a critical step to gain insight into the mechanism of DA neuron degeneration and design definitive disease-modifying therapies that will eliminate the burden of these common and dreadful conditions. (bmj.com)
- Numerous inherited abnormalities, such as morphological substrates for SIDS-sudden intrauterine unexplained death syndrome (SIUDS), were detected, mainly represented by variations of cardiac conduction system just like accessory pathway, abnormal resorptive degeneration, and hypoplasia/agenesis of the vital brainstem structures. (frontiersin.org)
- PD is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the midbrain. (intechopen.com)
- Morphological features of PD are degeneration of the dopaminergic striatonigral system, responsible for the core motor deficits, and a multifocal involvement of the central, peripheral, and autonomic nervous system and other organs associated with widespread occurrence of Lewy bodies in neurons and dystrophic Lewy neurites in cell processes. (springer.com)
- Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease. (springer.com)
- Pharmacological approaches targeting dopamine signaling and toxins leading to selective degeneration of nigral neurons are used to validate symptomatic treatments that aim at restoring effective dopaminergic function for motor control. (currentprotocols.com)
- Although genetic models have most often failed to induce overt degeneration of nigral dopaminergic neurons, they provide essential tools to explore the multifactorial etiology of this complex neurodegenerative disorder. (currentprotocols.com)
- In the past two years, our lab has developed robust procedures to generate these two classes of neurons from human embryonic stem cells and we have been studying the molecular changes that govern their specialization. (ca.gov)
- The efficient derivation of mature (Hb9+) motor neurons from embryonic stem cells is a sought-after goal in the understanding, and potential treatment, of motor neuron diseases. (biomedcentral.com)
- Conditions that promote the robust generation of motor neuron progenitors from embryonic stem cells and that promote the survival of differentiated motor neurons ex vivo are likely, therefore, to be critical in future biological/therapeutic/screening approaches. (biomedcentral.com)
- The effect of astrocyte-conditioned medium, moreover, is specific to motor neurons: we find that interneurons generated from mouse embryonic stem cells are unaffected by conditioned media from any type of astrocyte. (biomedcentral.com)
- Our study indicates that conditioned medium derived from wild type astrocytes enhances the efficient generation of motor neurons from mouse embryonic stem cells by enhancing motor neuron progenitors. (biomedcentral.com)
- The resulting rise in dopamine increases the strength of dopamine receptor activation in the hippocampus. (medicalxpress.com)
- This was confirmed by showing that pretreatment of mice with type 2 (D2) dopamine receptor blockers injected into the ventricles of the brain significantly reduced ventilation-induced apoptosis in the hippocampus. (medicalxpress.com)
- Dopamine alone had similar effects on dysbindin-1C in hippocampal slice preparations, effects that were inhibited by D2 receptor blockers. (medicalxpress.com)
- In this review, we focus mainly on the function of the dopamine receptor on Bio-behavior of tumor as a potential therapeutic target. (jcancer.org)
- The genetic structure of two type dopamine receptor could be also different. (jcancer.org)
Loss of midbrain2
- There is a progressive loss of midbrain DA neurons during normal aging ( 11 ), and the observed accumulation of somatic mtDNA mutations may cause a respiratory chain deficiency that contributes to this cell loss ( 7 ). (pnas.org)
- The progressive development of the loss of midbrain neurons had several of the key features of PD. (alzforum.org)
- Extrapolation from series of postmortem brains with Lewy body pathology in the substantia nigra predicted a preclinical stage of approximately 5 years.3 Similarly, striatal fludeoxyglucose 18 dopamine positron emission tomography studies4-6 estimated a 6-year preclinical phase. (scribd.com)
- These did not contain α-synuclein, a major component of the Lewy bodies found in the neurons of people with PD. (alzforum.org)
- The other features are microglial proliferation and the accumulation of an insoluble protein -alpha-synuclein, called "Lewy bodies" inside the surviving neurons. (hpathy.com)
- Importantly.7 2001 Savica et al.14 2007 Stiasny-Kolster et al.17 Patients with isolated RBD have reduced dopamine in the striatum. (scribd.com)
- The result is profound dopamine deficiency in the SNPc and striatum with emergence of the motor manifestations of the disease, i.e., bradykinesia, muscular rigidity, and hand tremor [6, (aimsci.com)
- cortex, hippocampus, striatum and cerebellum of BDL rats had impaired activity of mitochondrial respiratory chain enzymes. (springermedizin.de)
- Removal of the dopamine input protected the denervated striatum from the neurotoxic effects of systemic 3-NP but did not prevent the formation of lesions in the intact striatum. (jneurosci.org)
- however, the mechanism underlying the selective loss of neurons from the striatum is not well understood. (jneurosci.org)
- We found that increased striatal dopamine release potentiated the formation of striatal 3-NP lesions and that decreased dopamine levels prevented lesion formation in the striatum. (jneurosci.org)
- To test this idea, we introduced the mutated form of the SOD1 gene into astrocytes - cells that provide metabolic and structural support to neurons - and cultured our stem cell-derived motor neurons along with these SOD1-mutant astrocytes. (ca.gov)
- Indeed, while motor neurons grown on 'normal' astrocytes were fully viable, we saw widespread death of motor neurons in cocultures with 'mutant' astrocytes, along with elevated levels of free radicals. (ca.gov)
- We think that this is due to our mutant astrocytes being causing inflammation, and so our future efforts are focused on understanding the role of the immune system, specifically the function of microglia - the resident immune cells of the brain and spinal cord - in our co-cultures with human motor neurons. (ca.gov)
- Previous studies have shown that astrocytes have a protective effect on differentiated motor neurons ( in vivo and ex vivo ), but it remains unclear whether astrocytes also play a beneficial role in the support of motor neuron progenitors. (biomedcentral.com)
Levels of dopamine2
- The pleasurable effects of alcohol ingestion are the result of increased levels of dopamine and endogenous opioids in the reward pathways of the brain. (wikipedia.org)
- Akt suppression was clearly evident in the hippocampus of the ventilated mice and was associated with a hyperdopaminergic state (increased levels of dopamine) in that brain area. (medicalxpress.com)
Midbrain DA neurons4
- It has recently been demonstrated that midbrain DA neurons of PD patients and elderly humans contain high levels of somatic mtDNA mutations, which may impair respiratory chain function. (pnas.org)
- Additional support comes from experimental studies with toxins that inhibit complex I of the mitochondrial respiratory chain and cause death of midbrain DA neurons ( 6 ). (pnas.org)
- The somatic mtDNA mutation levels in midbrain DA neurons were much higher than these levels in other types of neurons ( 7 ). (pnas.org)
- The resulting MitoPark mouse strain has a homozygous disruption of Tfam in midbrain DA neurons and an unhealthy loss of cytochrome c oxidase (Cox) to boot. (alzforum.org)
- However, compound F05 does affect microtubule dynamics in cultured hippocampal neurons, suggesting a potential mechanism through which regeneration could be affected. (rutgers.edu)
- That possibility applies to ICU cases given the additional finding by the authors that total dysbindin-1 was increased in hippocampal neurons of ventilated compared to non-ventilated humans who died in the ICU. (medicalxpress.com)
- First author Mats Ekstrand and colleagues trained the system on the gene for mitochondrial transcription factor A (Tfam). (alzforum.org)
- Tfam is essential for healthy mitochondria because it not only controls the amount of DNA made in each organelle, but, as a master transcription factor, it also controls expression of mitochondrial genes. (alzforum.org)
Damage to mitochondria1
- Dopamine is what transports signals to the parts of the brain that control movement. (inquisitr.com)
- PD is the second most common neurodegenerative disease and develops when neurons in the brain, and in particular, in a part of the brain known as the substantia nigra die. (ca.gov)
- The exact causes for neuron death in PD are unknown but among others inflammation in the affected brain area may play a role in disease progression. (ca.gov)
- It would have been interesting to determine if the same thing occurs in other neurons, or with a more generalized mitochondrial dysfunction of brain, and whether this would result in a relatively selective vulnerability of dopaminergic neurons. (alzforum.org)
- Effects of this condition may lead to brain death or a persistent vegetative state. (scribd.com)
- Brain inflammation has also been found to be a factor in autism. (amalgam.org)
- 785 words - 4 pages It is surprising that music is not used in more medical treatments, there are many things that we as a public are uninformed of, and one is that music can really improve our heath.Music is wired to the motor areas of the brain. (ostatic.com)
- The motor is the same part of the brain that helps us move. (ostatic.com)
- 378 words - 2 pages Write a 350- to 700-word response to the following: Explain the communication process of neurons in the brain. (ostatic.com)
- and arcuate nucleus, are considered derivatives of the rhombic lip and five of the six regions contain serotonergic neurons in the developing human brain. (childrenshospital.org)
- This review summarizes the experimental, epidemiological and clinical evidence indicating that the ketogenic diet could have beneficial effects in a broad range of brain disorders characterized by the death of neurons. (sott.net)
- Studies in these neurodegenerative disorders have led to the hypothesis that the ketogenic diet may not only provide symptomatic benefit, but could have beneficial disease-modifying activity applicable to a broad range of brain disorders characterized by the death of neurons. (sott.net)
- The neurons are smaller and more densely packed, resulting in a reduced brain volume. (ptglab.com)
- The common predisposing factors are cerebral trauma, degenerative lesions and brain tumor (glioma) at the basal ganglia. (hpathy.com)
- The resulting neurohormonal cascade leads, in many cases, to the death of neurons in the brain, and in the central and peripheral nervous systems. (autismfile.com)
- CB1R are highly expressed in regions of the brain, such as the cortex, limbic system, hippocampus, cerebellum, brainstem and several nuclei in the basal ganglia (associated with emotion, cognition, memory, motor and executive function) . (oatext.com)
- Animal experiments have shown that investigated ENPs (metallic nanoparticles, quantum dots, carbon nanotubes) can translocate to the brain from different entry points (skin, blood, respiratory pathways). (biomedcentral.com)
- Although translocation to the brain via respiratory organs and the circulation appears to be very low, there remains a possibility that chronic exposures, and/or biopersistent ENPs, can influence processes within the brain that are triggering or aggravating pathological processes. (biomedcentral.com)
- The purpose of the present review is to give a short overview of how engineered nanoparticles (ENPs) can translocate from the respiratory tract to the circulation, pass the blood-brain-barrier (BBB), affect the brain, and to discuss possible adverse health effects and associated risks. (biomedcentral.com)
- Since the 1992 discovery, many groups have shown that stem cells in the brain (they are found throughout the nervous system) of all mammals, including humans, continually produce neurons in the olfactory bulb (smell centre) and the hippocampus (organ responsible for short term memory). (rutgers.edu)
- More remarkably, they have also shown that the production of new neurons may be central to vital brain functions such as short-term memory formation. (rutgers.edu)
- However, just some limited reviews have sufficiently analyzed the neurological substrates, albeit even subtle anomalies of the autonomic nervous system can measure the dysfunctions in the fundamental functions, prompting sudden and unexpected death ( 3 , 4 ). (frontiersin.org)
- Dr. Kinney and colleagues are testing the idea that SIDS, or a subset of SIDS, is due to a developmental brainstem defect in autonomic and/or respiratory control during sleep. (childrenshospital.org)
- The PHOX2B gene codes for a transcriptional factor responsible for regulating expression of genes involved with the development of the autonomic nervous system, such as dopamine-β-hydroxylase (DBH), PHOX2A, and TLX-2. (medscape.com)
Amyotrophic lateral s3
- Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease characterized by the formation of protein inclusion and progressive loss of motor neurons, finally leading to muscle weakness and respiratory failure. (springer.com)
- Motor neurons (MNs) are selectively depleted, or diminished, in motor neuron diseases such as amyotrophic lateral sclerosis (ALS). (biomedcentral.com)
- ALS) Amyotrophic Lateral Sclerosis or (MND) Motor Neurone Disease are referred to as ALS/MND. (goulburn.net.au)
- Since last year, we have been using neurons to elucidate the molecular mechanisms that underlie the demise of these cells. (ca.gov)
- Animal models and physiological data demonstrate that sleep, arousal, and cardiorespiratory malfunctioning are abnormal mechanisms in SIUDS risk factors or in newborn children who subsequently die from SIDS. (frontiersin.org)
- There is need to focus more on research in this area to unveil the major curtain to neuroprotection by underlying mechanisms leading to such deaths. (frontiersin.org)
- The chapter will review the evidence suggesting that some agents - and dopamine agonists in particular - are neuroprotective and the possible mechanisms whereby these effects might occur. (springer.com)
- Although the mechanisms underlying this disease are still unclear, PD is widely believed to be caused by multiple factors. (thefreelibrary.com)
- We found that the Nurr1 gene is turned on by inflammatory signals and suppresses genes that encode neurotoxic factors. (ca.gov)
- We found that the major CNS inhibiting substrates including chondroitin sulfate proteoglycans (CSPG) could inactivate protein kinase B (Akt) and activate GSK-3β signals in neurons. (rutgers.edu)
- The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds. (google.com)
- The hypothesis that mitochondrial dysfunction may be of etiological importance in PD has recently gained renewed attention because it has been shown that PD patients have an increased fraction of respiratory chain deficient DA neurons ( 7 ). (pnas.org)
- The same study reported ≈3% COX deficient DA neurons in the midbrain of PD patients, whereas the levels were much lower in age-matched controls ( 7 ). (pnas.org)
- This transport system is critical to allow peripheral neurons to repair themselves after injury and may be absent or deficient in neurons within the central nervous system (CNS). (mcponline.org)
- DRG neurons possess two axonal branches: a peripheral axon that regenerates when injured and a centrally projecting axon that does not regenerate following injury. (mcponline.org)
- The botulinum toxin can apparently pass unattenuated through the lining of the gut and attack peripheral motor neurons. (google.com)
- The ANS is a visceral and largely involuntary motor/effector system that is traditionally divided into sympathetic (thoracolumbar) and parasympathetic (craniosacral) divisions, each with a central and a peripheral component. (aappublications.org)
- Diffuse disease affecting the peripheral nerves may have a greater impact on either motor or sensory fibres, or it may affect both to an equal degree. (britannica.com)
- A midline lesion of the medulla oblongata is likely to involve the pyramidal tracts (the descending motor pathway) and the medial lemnisci (the ascending tracts relaying sensory impulses from the dorsal columns of the spinal cord). (britannica.com)
- This lesion may produce signs of an upper motor-neuron lesion and dorsal column-type sensory loss at all levels below the medulla. (britannica.com)
- In a joint effort with the laboratories of Christopher Glass and Michael Rosenfeld at the University of California, San Diego, we showed using animal experiments that a protein called Nurr1 is crucial for the development and survival of dopaminergic neurons. (ca.gov)
- Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. (nih.gov)
- Prognosis an increased affinity for opioid dependence given daily for d in the feet proportionately to the catheter may slip during dressing or tubing changes, or the factor viii protein. (bac.edu)
- MeCP2 is a nuclear protein that is expressed widely in different tissues but is most abundant in the neurons of a mature nervous system (1, Figure 1). (ptglab.com)
- They have shown motor deficits, which respond to L-dopa therapy. (alzforum.org)
- The failure of central nervous system (CNS) neurons to regenerate following spinal cord injury (SCI) leads to irreversible paralysis and sensory deficits. (rutgers.edu)
- The resulting striatal dopamine deficiency and other complex biochemical deficits cause the heterogeneous clinical picture of the disease. (springer.com)
- Table 1.9 factors affecting midline incisional hernia following 2,145 open hysterectomies- defining indications and opportunities for its selective action, the long run, one aims at providing safe withdrawal to make them easily legible in normal subjects and can aggravate a-v conduction in the kidneys, it is better to use canes, crutches, walkers, or wheelchairs. (yogachicago.com)
- For example, injury to the cord at mid-thoracic levels spares the arms, which are innervated by fibres originating from higher segments, but it causes characteristic signs (abnormal posture, spastic tone, weakness, increased deep reflexes, and abnormal plantar reflexes) of damage to motor neurons originating below that level-as well as the loss of bladder and bowel control. (britannica.com)
- It is normally released by neurons to activate reflexes of satisfaction and reward. (mediologiest.com)