Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Cord Blood Stem Cell Transplantation: Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Exchange Transfusion, Whole Blood: Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.Blood DonorsTransplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Blood Transfusion: The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Fetal Blood: Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.Hematologic Neoplasms: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.Peripheral Blood Stem Cell Transplantation: Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.Transplantation Chimera: An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.Histocompatibility Testing: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.ABO Blood-Group System: The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Kidney Transplantation: The transference of a kidney from one human or animal to another.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Mesenchymal Stem Cell Transplantation: Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).Cell Transplantation: Transference of cells within an individual, between individuals of the same species, or between individuals of different species.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Blood: The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.Embryonic Stem Cells: Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.Heart Transplantation: The transference of a heart from one human or animal to another.Myeloablative Agonists: Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Living Donors: Non-cadaveric providers of organs for transplant to related or non-related recipients.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Recurrence: The return of a sign, symptom, or disease after a remission.Busulfan: An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.Adult Stem Cells: Cells with high proliferative and self renewal capacities derived from adults.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Whole-Body Irradiation: Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.Histocompatibility: The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Transplantation Immunology: A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.Hematopoietic Stem Cell Mobilization: The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.Transplantation: Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.Graft vs Leukemia Effect: Immunological rejection of leukemia cells following bone marrow transplantation.Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Pluripotent Stem Cells: Cells that can give rise to cells of the three different GERM LAYERS.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Vidarabine: A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.Neural Stem Cells: Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.Stem Cell Niche: A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Antigens, CD34: Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.Immunosuppression: Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Mesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Transplantation, Isogeneic: Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.Hepatic Veno-Occlusive Disease: Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Transplants: Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Chimerism: The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Graft vs Tumor Effect: Immunological rejection of tumor tissue/cells following bone marrow transplantation.Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.Siblings: Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)Induced Pluripotent Stem Cells: Cells from adult organisms that have been reprogrammed into a pluripotential state similar to that of EMBRYONIC STEM CELLS.Islets of Langerhans Transplantation: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.Hematologic Diseases: Disorders of the blood and blood forming tissues.Antilymphocyte Serum: Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.Lymphocyte Transfusion: The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Multipotent Stem Cells: Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)Granulocyte Colony-Stimulating Factor: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.Lymphocyte Depletion: Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Hematopoiesis: The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).Acute Disease: Disease having a short and relatively severe course.Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cell Lineage: The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.Fetal Stem Cells: Cells derived from a FETUS that retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.Transplantation Tolerance: An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.Immunocompromised Host: A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.Cytarabine: A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)Fetal Tissue Transplantation: Transference of fetal tissue between individuals of the same species or between individuals of different species.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Unrelated Donors: Providers of tissues for transplant to non-related individuals.Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Stem Cell Factor: A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Infection: Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Mice, Inbred C57BLLeukapheresis: The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.Lymphoproliferative Disorders: Disorders characterized by proliferation of lymphoid tissue, general or unspecified.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Severe Combined Immunodeficiency: Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)Neoplasm, Residual: Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)Transplantation, Heterologous: Transplantation between animals of different species.Regeneration: The physiological renewal, repair, or replacement of tissue.Transplantation, Heterotopic: Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.Minor Histocompatibility Antigens: Allelic alloantigens often responsible for weak graft rejection in cases when (major) histocompatibility has been established by standard tests. In the mouse they are coded by more than 500 genes at up to 30 minor histocompatibility loci. The most well-known minor histocompatibility antigen in mammals is the H-Y antigen.Donor Selection: The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.Cell SeparationThiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).Heart-Lung Transplantation: The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)Virus Activation: The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.Stem Cell Research: Experimentation on STEM CELLS and on the use of stem cells.Cell Culture Techniques: Methods for maintaining or growing CELLS in vitro.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Antineoplastic Agents, Alkylating: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)Blood Group Incompatibility: An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.Bone Marrow Purging: Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Waiting Lists: Prospective patient listings for appointments or treatments.Vincristine: An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)Bronchiolitis Obliterans: Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.Allografts: Tissues, cells, or organs transplanted between genetically different individuals of the same species.Mycophenolic Acid: An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Cell- and Tissue-Based Therapy: Therapies that involve the TRANSPLANTATION of CELLS or TISSUES developed for the purpose of restoring the function of diseased or dysfunctional cells or tissues.Cadaver: A dead body, usually a human body.Ganciclovir: An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.Spermatogonia: Euploid male germ cells of an early stage of SPERMATOGENESIS, derived from prespermatogonia. With the onset of puberty, spermatogonia at the basement membrane of the seminiferous tubule proliferate by mitotic then meiotic divisions and give rise to the haploid SPERMATOCYTES.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.MycosesStomatitis: INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Brain Tissue Transplantation: Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Liver Diseases: Pathological processes of the LIVER.Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.Antibodies, Monoclonal, Murine-Derived: Antibodies obtained from a single clone of cells grown in mice or rats.Plant Stems: Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)Immunophenotyping: Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Neoplastic Stem Cells: Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Mice, SCID: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.Directed Tissue Donation: Tissue, organ, or gamete donation intended for a designated recipient.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Leukocyte Transfusion: The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.Blood Component Removal: Any procedure in which blood is withdrawn from a donor, a portion is separated and retained and the remainder is returned to the donor.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.Aspergillosis: Infections with fungi of the genus ASPERGILLUS.Lymphocyte Count: The number of LYMPHOCYTES per unit volume of BLOOD.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Epstein-Barr Virus Infections: Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).Colony-Forming Units Assay: A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.Corneal Transplantation: Partial or total replacement of the CORNEA from one human or animal to another.Nuclear Family: A family composed of spouses and their children.Tissue Transplantation: Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.Blood Cells: The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Cell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Platelet Transfusion: The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.Tissue and Organ Harvesting: The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.Chimera: An individual that contains cell populations derived from different zygotes.Roseolovirus Infections: Infection with ROSEOLOVIRUS, the most common in humans being EXANTHEMA SUBITUM, a benign disease of infants and young children.Antibodies, Neoplasm: Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.Dexamethasone: An anti-inflammatory 9-fluoro-glucocorticoid.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Lymphoma, Follicular: Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.Lymphoma, Mantle-Cell: A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
Hematopoietic stem cell transplantation
... ex-vivo expansion of cord blood units or the use of two cord blood units from different donors allow cord blood transplants to ... "Peripheral blood stem cells for allogeneic transplantation: a review". Stem Cells. 19 (2): 108-17. doi:10.1634/stemcells.19-2- ... Peripheral blood stem cells are now the most common source of stem cells for HSCT. They are collected from the blood ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ...
Welsh Blood Service
It also operates a national panel of unrelated potential blood stem cell donors - the Welsh Bone Marrow Donor Registry. Medical ... the Welsh Transplantation & Immunogenetics Laboratory, providing direct support to local providers of Renal and Stem Cell ... with NHS Blood and Transplant, covering North Wales. The research and development activity within the Welsh Blood Service ... The Welsh Blood Service's roles include the collection of voluntary, non-remunerated blood, platelet and stem-cell donations ...
Bone Marrow Donors Worldwide
... such as search coordinators and transplant physicians from transplant centres, stem cell donor registries, and cord blood banks ... "Bone Marrow Transplantation 51: 675-679". 2015 - Gratwohl A, et al. One million hematopoietic stem-cell transplants: a ... These global hematopoietic cells from donors or cord blood units are used to transplant patients around the world with a ... fast preliminary search tool to find the best matched stem cell donor or cord blood unit for a patient in need of a transplant ...
Hematopoietic stem cell transplantation
... ex-vivo expansion of cord blood units or the use of two cord blood units from different donors allow cord blood transplants to ... Peripheral blood stem cells are now the most common source of stem cells for HSCT. They are collected from the blood through a ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... The red blood cells are returned to the donor. The peripheral stem cell yield is boosted with daily subcutaneous injections of ...
Donor lymphocyte infusion
Loren AW, Porter DL (2006). "Donor leukocyte infusions after unrelated donor hematopoietic stem cell transplantation". Current ... to augment an anti-tumor immune response or ensure that the donor stem cells remain engrafted. These donated white blood cells ... Formerly, the only treatment option that offered relapsed bone marrow transplant patients hope of a cure was another bone ... Donor leukocyte infusion is the infusion in which lymphocytes from the original stem cell donor are infused, after the ...
Total body irradiation
... preventing immunologic rejection of transplanted donor bone marrow or blood stem cells. Additionally, high doses of total body ... The number of pregnancies observed after hematopoietic stem cell transplantation involving such as procedure is lower than 2%. ... and allogeneic peripheral blood stem cell transplant". Bone Marrow Transplant. 40 (6): 573-8. doi:10.1038/sj.bmt.1705771. PMID ... Tichelli André, Rovó Alicia (2013). "Fertility Issues Following Hematopoietic Stem Cell Transplantation". Expert Rev Hematol. 6 ...
LifeSouth Community Blood Centers
... and stores umbilical cord blood for the purpose of clinical cures and basic research in the field of stem cell transplantation ... with the National Marrow Donor Program's Be The Match Registry and the Center for International Blood and Marrow Transplant ... hospitals were in critical need of volunteer blood donors after the FDA curtailed the practice of paying donors for blood ... LifeCord is a program of LifeSouth Community Blood Centers which performs community and donor education, cord blood collection ...
"Unrelated donor hematopoietic cell transplantation: Marrow or umbilical cord blood?". Blood. 101 (11): 4233-44. doi:10.1182/ ... GvHD is commonly associated with stem cell transplants such as those that occur with bone marrow transplants. GvHD also applies ... The T-cells of umbilical cord blood (UCB) have an inherent immunological immaturity, and the use of UCB stem cells in ... to other forms of transplanted tissues such as solid organ transplants. White blood cells of the donor's immune system which ...
Peripheral stem cell transplantation
"Stem Cell Transplant (Peripheral Blood, Bone Marrow, and Cord Blood Transplants)". Retrieved 4 March 2012. "Peripheral Blood ... PBSC donors are given a course of GCSF prior to PBSC collection, this ensures a better outcome, as stem cell proliferation ... Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood- ... "Peripheral blood stem cells for allogeneic transplantation: a review". Stem cells (Dayton, Ohio). 19 (2): 108-17. doi:10.1634/ ...
Under ReliCord S the stored cord blood stem cells can be used for haematopoetic stem cell transplantation for family members ... not only stores the stem cells but also tests and processes the same along with delivering the stem cells to the transplant ... ReliCord S is a program for sibling donors. This program is for a mother or a family that wants to process and bank the ... ReliCord A offer stem cell enriched cord blood repository services as well as stem cell enriched cord blood for transplantation ...
African-Caribbean Leukaemia Trust
... patients finding a stem cell match, receiving blood or receiving an organ through transplantation, though statistics as they ... to receive a lifesaving bone marrow transplant from an unrelated donor. In 2008 the development of the organisation into a ... Daniel's only hope of survival was to receive a stem cell transplant; stem cells have racially specific characteristics ... Today, a Black, Asian or ethnic minority who is in need of a stem cell transplant has less than a 20% chance of finding the ...
Transplantation of stem cells are taken from the bone marrow, peripheral blood or umbilical cord of healthy, matched donors. ... Similarly, in bone transplant, stem cells are able to find their way back through tracking mechanisms. Pannicke, Ulrich; Hönig ... Hematopoietic stem cells give rise to blood cells. Differentiation and proliferation of hematopoietic stem cells require a lot ... Stem cells are taken from an affected child's blood or bone marrow. Then in laboratory conditions the stem cells are ...
... appears after allogeneic hematopoietic stem cell transplantation (HSCT). The graft contains donor T cells (T lymphocytes) that ... treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: ... particularly in T-cell-depleted HLA-haploidentical HSCT. Graft-versus-host disease Hematopoietic stem cell transplantation ... "Graft-versus-leukemia effects of transplantation and donor lymphocytes". Blood. 112 (12): 4371-83. doi:10.1182/blood-2008-03- ...
June 2008). "Stem cell transplantation for primary immunodeficiencies". Bone Marrow Transplant. 41 Suppl 2: S83-6. doi:10.1038/ ... such as otherwise healthy blood donors) having a rate of 1:600. Other disorders are distinctly more uncommon, with incidences ... cell responses to mitogens and allogeneic cells, cytokine production by cells Tests for B cell function: antibodies to routine ... Virus-specific T-Lymphocytes (VST) therapy is used for patients who have received hematopoietic stem cell transplantation that ...
Healthcare Systems Bureau
Bill Young Cell Transplantation Program and National Cord Blood Inventory, HRSA helps make possible blood stem cell transplants ... Stem cells for transplant come from adult volunteer donors and umbilical cord blood units donated to public cord blood banks. ... "What you must know about umbilical cord stem cells". U.S. Government Accountability Office, Report to Committees: Drug Pricing ... The program recruits adult volunteer donors, helps member cord blood banks collect and list additional units, and supports ...
Updated: 16 December 2013 Why Perform a Stem Cell Transplant? *^ Bone Marrow Transplantation and Peripheral Blood Stem Cell ... It is this side effect of conventional chemotherapy strategies that the stem-cell transplant attempts to reverse; a donor's ... and such research involves adult stem cells, amniotic stem cells, and induced pluripotent stem cells. ... Healthy adult brains contain neural stem cells which divide to maintain general stem-cell numbers, or become progenitor cells. ...
"Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation". Blood. 117 (10): 2791-9. doi:10.1182/blood- ... the disease and mortality risk associated with stem cell transplants, and the difficulty of finding suitable donors. ... "Evidence for the cure of HIV infection by CCR532/32 stem cell transplantation". Blood. 117 (10): 2791-2799. doi:10.1182/blood- ... Stem cell based gene therapy. In the past 7 years, scientists have been using different approaches of stem cell based ...
Granulocyte colony-stimulating factor
... stem cells in the blood of the donor before collection by leukapheresis for use in hematopoietic stem cell transplantation. For ... Stem cell transplantsEdit. G-CSF may also be given to the receiver in hematopoietic stem cell transplantation, to compensate ... White blood cells. The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G- ... "G-CSF-primed bone marrow as a source of stem cells for allografting: revisiting the concept". Bone Marrow Transplantation. 50 ( ...
... bone marrow transplantation mice 2007 Comparison of efficiencies mobilizing stem cells into peripheral blood in healthy donors ... published in Biol Blood Marrow Transplant. 2008 Acute graft versus host disease in non-myeloablative allogeneic stem cell ... blood stem cell transplantation 2005 Establishment of a rhesus haploidentical hematopoietic stem cell and mesenchymal stem cell ... stem cell transplantation and mesenchymal stem cells 2013 Haploidentical nonmyeloablative allogeneic peripheral blood stem cell ...
... the charity then use this blood in their stem cell transplants. In 2012 Anthony Nolan became the first stem cell register in ... Anthony Nolan is a UK charity that works in the areas of leukaemia and hematopoietic stem cell transplantation. It manages and ... Today the trust register has over 500,000 potential donors on it. One of the charity's main aims is to recruit more male donors ... "NHS BLOOD AND TRANSPLANT SEPTEMBER 2013" (PDF). NHS Blood & Transplant. Retrieved 23 May 2014. "What we do". AnthonyNolan.org. ...
... hematopoietic cell transplantation stem cell transplantation (4th ed.). Oxford: Wiley-Blackwell. ISBN 9781444303537. Haller M J ... A cord blood bank may be private (i.e. the blood is stored for and the costs paid by donor families) or public (i.e. stored and ... The first successful cord blood transplant (CBT) was done in 1988 in a child with Fanconi anemia. Early efforts to use CBT in ... It contains red blood cells, white blood cells, plasma, platelets and is also rich in hematopoietic stem cells. There are ...
John Raymond Hobbs
Who pioneered the use of alternative donors (and stem cells from peripheral blood) in bone marrow transplantation? Arch. Dis. ... Hobbs J.R.., Letter to British Medical journal., 7 December 1998: Bone marrow stem cell transplants (from alternative donors) ... In 1970 the world's first successful intended stem cell transplant for a previously fatal human disease. In 1971 the first ... The team became so skilled that, of their last 56 transplants from matched family donors, all survived for over 100 days (a ...
An embryo can be tissue typed to ensure that the embryo implanted can be a cord-blood stem cell donor for a sick sibling. One ... in order to match genetically similar individuals in hopes of performing a tissue transplantation. In this technique a donor's ... www.stanford.edu/dept/HPS/transplant/html/tt_1.html http://www.healthlinkbc.ca/kb/content/medicaltest/hw40261.html. ... Lysis results in the cell taking up a dye (trypan blue). This allows identification of cell's MHC indirectly based on the ...
... in freezing of umbilical cord blood or placental blood cells for the use for unrelated donors to treat diseases like Leukemia ... Following the first sibling-donor cord blood transplant in 1988, the National Institute of Health (NIH) awarded a grant to ... an international cord blood banking system and has played a leading role in international cord blood transplantation. Earning ... in order to establish the inventory of stem cell units necessary to provide unrelated, matched grafts for patients. In 1993, ...
The Berlin Patient
"Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation". Blood. 117: 2791-2799. doi:10.1182/blood-2010 ... He received a stem cell transplant from a donor naturally immune to HIV and has remained off antiretroviral therapy since the ... Timothy received two stem cell transplants from one donor homozygous for the delta32 mutation: one in 2007 and one in 2008. ... Gero Hütter, at Charité Hospital in Berlin, arranged for him to receive a hematopoietic stem cell transplant from a donor with ...
Juvenile myelomonocytic leukemia
Only Hematopoietic Stem Cell Transplantation (HSCT), commonly referred to as a bone marrow or (umbilical) cord blood transplant ... Donor: Transplants from a matched family donor (MFD), matched unrelated donor (MUD), and matched unrelated umbilical cord blood ... high white blood cell count in blood), absolute monocytosis (high monocyte count in blood), anemia (low red blood cell count in ... The only treatment that has resulted in cures for JMML is stem cell transplantation, also known as a bone marrow transplant, ...
Human leukocyte antigen
... and liver transplantation. In some diseases requiring hematopoietic stem cell transplantation, preimplantation genetic ... In order to create a typing reagent, blood from animals or humans would be taken, the blood cells allowed to separate from the ... This is particularly important in the case of transplanted tissue, because it could lead to transplant rejection. Because of ... Donor-specific HLA antibodies have been found to be associated with graft failure in kidney, heart, lung, ...
Cord blood bank
... and blood disorders. On the possibility that cord blood stem cells could be used for other purposes, the World Marrow Donor ... needing a transplant The public in the United States has a general awareness of embryonic stem cells because of the stem cell ... Only nine cases involved giving cord blood back to the donor, a practice known as autologous transplantation and the chief ... However, cord blood stem cells (hematopoietic stem cells) are not embryonic stem cells (pluripotent stem cells). Cryo-Cell ...
Matched HLA between donor and recipient is not necessary. The stem cells are collected from donor's blood through a process ... which will be reinitiated by donor's stem cells soon after transplantation, and will play a role as recipient-versus-tumor (RVT ... will also accelerate functional recovery of recipient's hematopoietic stem cells, greatly reducing infections and transplant- ... effect combining donor cells' graft-versus-tumor (GVT) effect. Donor's stem cells, which have been processed, ...
T细胞 - 维基百科，自由的百科全书
T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation. Blood Cancer ... Is Associated With Donor-Specific T Cell Hyporesponsiveness and Fewer Late Acute Rejections After Liver Transplantation. ... Disappearance of T Cell-Mediated Rejection Despite Continued Antibody-Mediated Rejection in Late Kidney Transplant Recipients. ... doi:10.1182/blood-2010-05-283770.. *^ Belikov AV, Schraven B, Simeoni L. T cells and reactive oxygen species. Journal of ...
Sex reassignment surgery
Further in the future, stem cell biotechnology may also make this possible, with no need for anti-rejection drugs. ... Nair, A.; Stega, J.; Smith, J. R.; Del Priore, G. (2008). "Uterus Transplant: Evidence and Ethics". Annals of the New York ... Other health conditions such as diabetes, abnormal blood clotting, ostomies, and obesity do not usually present a problem to ... Medical advances may eventually make childbearing possible by using a donor uterus long enough to carry a child to term as anti ...
A rare population of hematopoietic progenitor cells enter the thymus from the blood, and expands by cell division to generate a ... A thymus may be transplanted, however, this approach is problematic due to donor requirements and matching tissue with the ... derived from bone marrow resident hematopoietic stem cells). Developing T cells are referred to as thymocytes and are of ... The newly formed organ resembled a normal thymus histologically and molecularly, and upon transplantation it was able to ...
... showed that photoreceptor cells could be transplanted successfully in the mouse retina if donor cells were at a critical ... Successful photoreceptor transplantation, MIT Technology Review, November 2006. How stem cells might restore sight Technology ... The optic nerve carries the ganglion cell axons to the brain, and the blood vessels that supply the retina. The ganglion cells ... Cells. *Photoreceptor cells (Cone cell, Rod cell) → (Horizontal cell) → Bipolar cell → (Amacrine cell) → Retina ganglion cell ( ...
... cells that produce white and red blood cells) are destroyed, meaning allogenic or autologous bone marrow cell transplants are ... In chemotherapy as a conditioning regimen in hematopoietic stem cell transplantation, a study of patients conditioned with ... the source is a donor.) However, some patients still develop diseases because of this interference with bone marrow.[citation ... Chemotherapy drugs are also used in conditioning regimens prior to bone marow transplant (hematopoietic stem cell transplant). ...
Beating heart cadaver
Heart transplantation Organ donation Transplant surgery Brain stem death Non-heart-beating donation Legal death Clinical death ... There is a guideline for organ transplantation consisting of two parts. It states that organ donors must be dead before ... A beating heart cadaver requires a ventilator to provide oxygen to its blood, but the heart will continue to beat on its own ... The heart contains pacemaker cells that will cause the heart to continue beating even when a patient is brain-dead. Other ...
The living cells that can cause these movements are not living cells from the brain or brain stem, these cells come from the ... When mechanical ventilation is used to support the body of a brain dead organ donor pending a transplant into an organ ... Also, a radionuclide cerebral blood flow scan that shows complete absence of intracranial blood flow must be considered with ... Since the 1960s, laws on determining death have, therefore, been implemented in all countries with active organ transplantation ...
... alternative to the more traditional treatment with melphalan in people who are ill-suited for autologous stem cell transplant.[ ... "Immunosuppressive effect of cyclophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of Balb/c ... for donor T cells) has been used to enhance immunity in naïve hosts, and to enhance adoptive T cell immunotherapy regimens, as ... Bone Marrow Transplantation. 24 (12): 1367-8. doi:10.1038/sj.bmt.1702097. PMID 10627651.. ...
... from adult stem cells or progenitor cells would contribute to overcoming the shortage of donor organs for transplantation. The ... Hormones produced in the pancreatic islets are secreted directly into the blood flow by (at least) five types of cells. In rat ... which would offer an alternative to a complete pancreas transplant or artificial pancreas. Islet transplantation ... activates beta cells and inhibits alpha cells. *Glycogen/Glucagon: activates alpha cells which activates beta cells and delta ...
Limfocyty T regulatorowe, wolna encyklopedia
CD25+ T cells in the peripheral blood of lung transplant recipients: correlation with transplant outcome. „Transplantation". 77 ... Cytokine concentrations and regulatory T cells in living donor and deceased donor liver transplant recipients. „Pediatr ... immunoregulatory T cells for the control of graft-versus-host disease after allogeneic hematopoietic stem-cell transplantation ... Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. „Blood". 98 (9), s. 2736-2744, listopad 2001 ...
... in which a living or deceased donor's organ is transplanted into a person with a failing organ. The transplantation of larger ... Cardiovascular system: pumping and channeling blood to and from the body and lungs with heart, blood and blood vessels. ... In biology, tissue is a cellular organizational level between cells and complete organs. A tissue is an ensemble of similar ... For example, the liver evolved in the stem vertebrates more than 500 million years ago, while the gut and brain are even more ...
... porcine donors must be extensively screened before transplantation. Studies have also shown that some porcine transplant cells ... Donor stem cells are introduced into the bone marrow of the recipient, where they coexist with the recipient's stem cells. The ... Problems include their smaller body size, the infrequency of blood group O (the universal donor), their long gestation period, ... The existence of donor stem cells in the recipient's bone marrow causes donor reactive T cells to be considered self and ...
Bone marrow/Adult stem cell (living-donor and autograft). *Blood transfusion/Blood Parts Transfusion (living-donor and ... stem cells or healthy cells extracted from the donor site). Timeline of transplantsEdit. *1869: First skin autograft- ... Living donorEdit. In living donors, the donor remains alive and donates a renewable tissue, cell, or fluid (e.g., blood, skin ... The donor is her twin sister.. *2008: First transplant of a human windpipe using a patient's own stem cells, by Paolo ...
The marrow's hematopoietic stem cells-the reservoir of stem cells replenishing exhausted blood cells including white blood ... "Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation". Nature Medicine. 10 (11): 1227-33. doi: ... Marrow transplant. Bone marrow transplant can replace the transplant recipient's immune system with the donor's, and the ... Lymphocytes of specific immunity T cells-including the subclasses helper T cells and killer T cells-and B cells. ...
Human leukocyte antigen
In some diseases requiring hematopoietic stem cell transplantation, preimplantation genetic diagnosis may be used to give rise ... In order to create a typing reagent, blood from animals or humans would be taken, the blood cells allowed to separate from the ... This is particularly important in the case of transplanted tissue, because it could lead to transplant rejection. Because of ... Donor-specific HLA antibodies have been found to be associated with graft failure in kidney, heart, lung, and liver ...
Gift of Life Marrow Registry
The Collection Center primarily collects blood stem cells from donors for transplant into a patient. The stem cells are taken ... "The US National Marrow Donor Program role in unrelated donor hematopoietic cell transplantation". Bone Marrow Transplantation. ... Peripheral Blood Stem Cells (PBSC): It is possible to collect stem cells from the peripheral blood rather than the bone ... This mobilizes stem cells to travel from the bone marrow into the circulating blood. The stem cells are collected through a ...
Confusion arose as some thought that the blood of British blood donors voluntarily donating to NHS Blood and Transplant ... Blood plasma is a yellowish coloured liquid component of blood that normally holds the blood cells in whole blood in suspension ... "NHS Blood and Transplant Services.. *^ Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services ... Blood plasma is separated from the blood by spinning a tube of fresh blood containing an anticoagulant in a centrifuge until ...
Updated: 16 December 2013 Why Perform a Stem Cell Transplant? *^ Bone Marrow Transplantation and Peripheral Blood Stem Cell ... It is possible to collect amniotic stem cells for donors or for autologuous use: the first US amniotic stem cells bank  ... mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, dental pulp stem cell, etc.). Muse cells ( ... Stem cell division and differentiation A: stem cell; B: progenitor cell; C: differentiated cell; 1: symmetric stem cell ...
Diabetes mellitus type 1
In 2014 more mature beta cells were produced which released insulin in response to blood sugar when transplanted into mice. ... Stem cells. Pluripotent stem cells can be used to generate beta cells but previously these cells did not function as well ... Islet cell transplantation. Main article: Islet cell transplantation. Islet cell transplantation may be an option for ... some people with type 1 diabetes that is not well controlled with insulin. Difficulties include finding donors that are ...
National Marrow Donor Program. *NOD-Lb. *National Transplant Organization. *NHS Blood and Transplant ... Many recent advances in reducing complications due to tissue rejection stem from mouse heart transplant procedures. The ... A heart transplant, or a cardiac transplant, is a surgical transplant procedure performed on patients with end-stage heart ... "The Impact of Donor-Recipient Sex Matching on Survival After Orthotopic Heart Transplantation: Analysis of 18 000 Transplants ...
1999). «Autologous haematopoietic stem cell transplants for autoimmune disease--feasibility and transplant-related mortality. ... Autoimmune Disease and Lymphoma Working Parties of the European Group for Blood and Marrow Transplantation, the European League ... Den kan vere autolog (pasienten sine eigne stamceller) eller allogen (stamceller frå ein donor). Inngrepet høyrer til under ... Denne artikkelen bygger på «Hematopoietic stem cell transplantation» frå Wikipedia på engelsk, den 8. januar 2015. ...
T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation". Blood Cancer ... T-killer cells, killer T cells) destroy virus-infected cells and tumor cells, and are also implicated in transplant rejection. ... Is Associated With Donor-Specific T Cell Hyporesponsiveness and Fewer Late Acute Rejections After Liver Transplantation". ... Helper CD4+ T cellsEdit. T helper cells (TH cells) assist other lymphocytes, including maturation of B cells into plasma cells ...
2004).Effective treatment of alpha-mannosidosis by allogeneic hematopoietic stem cell transplantation. J Pediatr, 144:569-573. ... Identification of disease-causing mutations is achieved using DNA from peripheral blood cells, by polymerase chain reaction ( ... is that enzyme-producing donor cells repopulate the host tissue and transfer enzyme to nearby enzyme-deficient host cells. ... The benefits are greater in younger patients before complications have developed, and also transplant related complications are ...
Virus del Zika - Viquipèdia, l'enciclopèdia lliure
Cell Stem Cell, 2016 Nov 3; 19 (5), pàg. 663-671. DOI: 10.1016/j.stem.2016.07.019. PMC: 5144538. PMID: 27524440 [Consulta: 3 ... Saá P, Proctor M, Foster G, Krysztof D, et al «Investigational Testing for Zika Virus among U.S. Blood Donors» (en anglès). N ... Kotton, CN «Zika Virus and Solid Organ Transplantation: Significant Pathogen or Harbinger of Things to Come?» (en anglès). ... Am J Transplant, 2017 Abr 27, pàgs: 3. DOI: 10.1111/ajt.14334. PMID: 28452113 [Consulta: 2 maig 2017]. ...
Impact of pretransplant donor-specific anti-HLA antibodies on cord blood transplantation on behalf of the Transplant...
CBT with pretransplant anti-HLA antibodies using the database of Japan Society for Hematopoietic Cell Transplantation (JSHCT). ... donor-specific anti-HLA antibodies (DSA) was reported to be associated with an increased risk of GF after CBT, data are still ... remains a major complication of cord blood transplantation (CBT). Although the presence of pretransplant, ... Donor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantation. Blood. 2011; ...
Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with...
Bone Marrow Transplant. 2019 May 31. doi: 10.1038/s41409-019-0582-5. [Epub ahead of print] ... Medical Park, Stem Cell Transplant Unit, Antalya, Turkey.. 12. Erasmus MC Cancer Institute, University Medical Centre, ... Cord blood transplantation (UCBT) and non-T-cell-depleted stem cell transplantation from haploidentical donors (HAPLO) are both ... Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with ...
Donor Atorvastatin Treatment for Preventing Severe Acute Graft-Versus-Host Disease in Patients Undergoing Myeloablative...
Peripheral Blood Stem Cell Transplantation Undergo myeloablative allogeneic PBSC transplant. Other Names: *PBPC transplantation ... red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response ... Procedure: Allogeneic Hematopoietic Stem Cell Transplantation Drug: Atorvastatin Calcium Procedure: Peripheral Blood Stem Cell ... It may also prevent the patients immune system reject the donors stem cells. When the healthy stem cells from a donor are ...
Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood...
... cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors ... cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors ... cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors ... cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors ...
Frontiers | Is There Any Reason to Prefer Cord Blood Instead of Adult Donors for Hematopoietic Stem Cell Transplants? | Medicine
... the advantage and disadvantages of CB compared to adult stem cells within the context of stem cell biology and transplantation. ... Cord blood progenitor/stem cell content has been compared with adult stem cells revealing higher long-term repopulating ... Cord blood progenitor/stem cell content has been compared with adult stem cells revealing higher long-term repopulating ... the advantage and disadvantages of CB compared to adult stem cells within the context of stem cell biology and transplantation. ...
CRISPR/Cas9-modified hematopoietic stem cells-present and future perspectives for stem cell transplantation | Bone Marrow...
However, this approach has limitations related to lack of a suitable donor, graft-versus-host disease and infectious ... Allogeneic hematopoietic stem cell transplantation (HSCT) is a standard therapeutic intervention for hematological malignancies ... guidelines from the american society for blood and marrow transplantation. Biol Blood Marrow Transplant. 2015;21:1863-9. https ... CRISPR/Cas9-modified hematopoietic stem cells-present and future perspectives for stem cell transplantation. *Alberto Daniel- ...
Thrombasthenia Clinical Presentation: History, Physical, Causes
Successful unrelated donor cord blood transplantation for Glanzmanns thrombasthenia. Pediatr Transplant. 2011 May. 15(3):e42-6 ... Sustained engraftment and resolution of bleeding phenotype after unrelated cord blood hematopoietic stem cell transplantation ... Stem cell transplantation for children with Glanzmann thrombasthenia. Br J Haematol. 2008 Mar. 140(5):568-71. [Medline]. ... Bone marrow transplantation in severe Glanzmanns thrombasthenia with antiplatelet alloimmunization. Bone Marrow Transplant. ...
Definition of allogeneic stem cell transplantation - NCI Dictionary of Cancer Terms - National Cancer Institute
... cells from which all blood cells develop) from a genetically similar, but not identical, donor. This is often a sister or ... A procedure in which a person receives blood-forming stem cells ( ... Stem cell transplant (Step 3). The patient receives stem cells ... donor. This is often a sister or brother, but could be an unrelated donor. Enlarge Stem cell transplant (Step 1). Blood is ... A procedure in which a person receives blood-forming stem cells (cells from which all blood cells develop) from a genetically ...
Reduced-Intensity Hematopoietic Stem Cell Transplant for High Risk Lysosomal and Peroxisomal Disorders - Full Text View -...
The cell source may be marrow, peripheral blood or cord blood based on donor availability. ... Hematopoietic stem cell transplantation Patients will be transplanted using either a related or unrelated allograft. The cell ... Donor Availability. *Transplantation using sufficiently matched related donors (such as matched siblings) or unrelated donors ... Hematopoietic stem cell transplantation will be infused on Day 0. Post-transplant immunosuppression to follow: Mycophenolate ...
Young JH[au] - PubMed - NCBI
Infections after Transplantation of Bone Marrow or Peripheral Blood Stem Cells from Unrelated Donors. ... Blood and Marrow Transplant Clinical Trials Network Trial 0201.. Biol Blood Marrow Transplant. 2016 Feb;22(2):359-370. doi: ... Mixed vs full donor engraftment early after hematopoietic cell transplant: Impact on incidence and control of cytomegalovirus ... Toward revision of antimicrobial therapies in hematopoietic stem cell transplantation: target the pathogens, but protect the ...
LLS Search Results | Leukemia and Lymphoma Society
Frozen cord blood is a source of donor stem cells for transplantation to HLA-matched recipients. Most cord-blood transplants ... Stem Cells. Primitive marrow cells that mature into red blood cells, white blood cells, and blood platelets. Stem cells are ... Stem Cell Transplantation. See Allogeneic Stem Cell Transplantation; Autologous Stem Cell Transplantation. ... Blood Cells. There are three types of blood cells: red blood cells, which carry oxygen; white blood cells, which fight ...
CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation - Full Text View -...
... and young adults receiving an allogeneic peripheral blood stem cell transplant from a family member or unrelated adult donor ... CD34+ stem cells are selected from the donors peripheral blood stem cells. In doing this, T-cells are also removed. T-cells ... Requirement for CD34+ stem cell selection for a second infusion of stem cells following an allogeneic stem cell transplant from ... Peripheral blood stem cell transplantation. Non-malignant disease. Langerhans Cell Histiocytosis (LCH). Sickle Cell Disease. ...
Blood & Marrow Stem Cell Transplantation: Managing Complications after an Allogeneic Transplant | Memorial Sloan Kettering...
Learn about the complications that may happen after an allogeneic transplant and how MSK works to prevent, manage, and treat ... Sometimes, the donors stem cells fail to grow and replace the patients blood cells after the transplant. This is called graft ... Blood & Marrow Stem Cell Transplantation More About Blood & Marrow Stem Cell Transplantation ... can happen if white blood cells that have formed from the donors stem cells recognize the patients cells and tissues as ...
Mindy G. Schuster | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of...
Infections Following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. Biology of Blood and ... Blood and Marrow Transplant Clinical Trials Network Trial 0201: Infections after Transplantation of Bone Marrow or Peripheral ... Blood Stem Cells from Unrelated Donors. Biol Blood Marrow Transplant 22(2): 359-70, 2016.. Pappas PG, Kauffman CA, Andes DR, ... Epidemiology and Outcomes of Clostridium difficile Infection in Allogeneic Hematopoietic Stem Cell and Lung Transplant ...
Haematopoietic stem cell transplantation in children and adolescents with non hodgkin lymphoma: an analysis of the European...
Autologous or allogeneic stem cell transplant. • Allogeneic donor: sibling, family, unrelated or cord blood. • Matched or ... Haematopoietic stem cell transplantation in children and adolescents with non hodgkin lymphoma: an analysis of the European ... The purpose of this study is to examine the role of hematopoietic stem cell transplantation for patients aged ,=18y diagnosed ... 2018 The European Society for Blood and Marrow Transplantation. All rights reserved ...
Hematopoietic stem cell transplantation: a primer for the primary care physician | CMAJ
Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and ... Blood stem cell transplantation is accomplished by treating the donor with hematopoietic growth factors, which cause the stem ... Engraftment: stem cell function begins. Engraftment is the process whereby the donor cells begin to produce new blood ... Allogeneic transplantation represents 40% of all stem cell transplants performed annually in Canada and requires donor and ...
Peripheral Stem Cell Transplantation in Treating Patients With Metastatic or Recurrent Kidney Cancer
Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy and... ... the transplanted cells can be rejected by the bodys tissues. Mycophenolate mofetil, tacrolimus, and donor white blood cells ... RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy and ... RATIONALE: Peripheral stem cell or bone marrow transplantation may be able to replace immune cells that were destroyed by ...
Cancer Research and Treatments | American Society of Clinical Oncology | CancerCare
In an allogeneic hematopoietic stem cell transplant, the person receives blood-forming stem cells from a genetically similar ... ½ inhibitors could have on the timing of allogeneic hematopoietic stem cell transplant and their effect on post-transplantation ... donor.). Ongoing research is being conducted on the impact JAK ... allogeneic hematopoietic stem cell transplant remains the only ... JAK1/2 inhibitors being studied in the context of stem cell transplantation for patients with myelofibrosis. Since its FDA ...
Blood and Bone Marrow Stem Cell Transplantation - UChicago Medicine
We are recognized for our expertise in alternative donor transplantation; relapse prevention and treatment; transplantation for ... we offer the full range of blood and bone marrow stem cell transplantation options. ... Pediatric Stem Cell Transplant. For information about stem cell transplant for children and teens, visit the Pediatric Stem ... Blood and Bone Marrow Stem Cell Transplantation. Wendy Stock, MD, is an expert in leukemia and stem cell transplantation. ...
PRIME PubMed | Total Body Irradiation-Based Myeloablative Haploidentical Stem Cell Transplantation Is a Safe and Effective...
Is a Safe and Effective Alternative to Unrelated Donor Transplantation in Patients Without Matched Sibling Donors. Download ... Total Body Irradiation-Based Myeloablative Haploidentical Stem Cell Transplantation ... Blood and Marrow Transplant Program, Northside Hospital, Atlanta, Georgia.. Sanacore M Blood and Marrow Transplant Program, ... Peripheral blood stem cells KW - Stem cell transplantation KW - Total body irradiation SP - 1299 EP - 307 JF - Biology of blood ...
Sirolimus, tacrolimus, and low-dose methotrexate as graft-versus-host disease prophylaxis in related and unrelated donor...
... prophylaxis in related and unrelated donor reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation ... Biol Blood Marrow Transplant. 2008 Aug; 14(8):920-6. View in: PubMed ... prophylaxis in related and unrelated donor reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation ... prophylaxis in related and unrelated donor reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation ...
MicroRNAs as biomarkers for graft-versus-host disease following allogeneic stem cell transplantation | SpringerLink
Allogeneic hematopoietic stem cell transplantation (HCT) is a well-established treatment for many malignant and non-malignant ... Allogeneic hematopoietic stem cell transplant using mismatched/haploidentical donors. Biol Blood Marrow Transplant 13(11):1249- ... Storb R (2004) History of pediatric stem cell transplantation. Pediatr Transplant 8(Suppl 5):5-11PubMedGoogle Scholar ... From stem cell to solid organ. Bone marrow, peripheral blood or umbilical cord blood as favorable source? Eur Rev Med Pharmacol ...
paroxysmal nocturnal hemoglobinuria (PNH) | Page 2 | Aplastic Anemia & MDS International Foundation
Hematopoietic stem cell transplantation; alternative donors transplant including umbilical cord blood, transplantation of ... Olsons clinical efforts focus on pediatric hematopoietic stem cell transplantation (HSCT), with a specific emphasis on HSCT ... Ron Paquette is a member of the Blood and Marrow Transplant Program at Cedars-Sinai. He is a physician and researcher who ...
Fanconi Anemia Treatment & Management: Approach Considerations, Supportive Care, Hematopoietic Stem Cell Transplantation and...
Alternative donor hematopoietic cell transplantation for Fanconi anemia. Blood. 2015 Jun 11. 125 (24):3798-804. [Medline]. ... Chromosomal Aberrations and Survival after Unrelated Donor Hematopoietic Stem Cell Transplant in Patients with Fanconi Anemia. ... Hematopoietic stem cell transplantation (bone marrow, cord blood, or peripheral blood stem cells) may cure aplastic anemia and ... the 1-year overall survival rate following unrelated-donor hematopoietic stem cell transplantation is poor in those with clonal ...
Peripheral blood transplants from donors may be more harmful than bone marrow transplants in pediatric leukemia patients
... from sibling donors may be more harmful than bone marrow in pediatric leukemia patients. ... A new study has shown for the first time that transplantation of peripheral blood stem cells (PBSC) ... or from an unrelated volunteer donor.Another approach is peripheral blood stem cell (PBSC) transplantation, in which these stem ... stem cells - immature cells found in the bone marrow that mature into red blood cells, white blood cells, and platelets.Doctors ...
Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant |...
CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors. Blood. ... transplant-related mortality (TRM), and/or overall survival (OS).1⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓ ... NOD2/CARD15 gene polymorphisms affect outcome in pediatric allogeneic stem cell transplantation. Blood. 2011;118(4):1181-1184. ... Toll-like receptor polymorphisms in allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2015;21(2):259 ...
Pediatric Blood Disorders Diagnosis | Memorial Sloan Kettering Cancer Center
Learn more about diagnosing pediatric blood disorders and how our team of experts can help you or your child only at Memorial ... or the replenishing of blood-forming stem cells from a donor. Our approach does not require total-body irradiation to destroy ... We also perform transplants without white blood cells known as T cells. A T-cell depleted transplant reduces the risk of graft- ... One of our approaches includes performing allogeneic hematopoietic stem cell transplantation (HSCT), ...
Co-transplantation of Hematopoietic Stem Cells and Cxcr4 Gene-Transduced Mesenchymal Stem Cells Promotes Hematopoiesis |...
Co-transplantation of MSCs and hematopoietic stem cells (HSCs) promotes successful engraftment and improves... ... Mesenchymal stem cells (MSCs) are a promising candidate for cellular therapies. ... Recovery of donor-derived peripheral blood leukocytes and platelets was accelerated when CXCR4-MSCs were co-transplanted with ... Co-transplantation of Hematopoietic Stem Cells and Cxcr4 Gene-Transduced Mesenchymal Stem Cells Promotes Hematopoiesis. ...
Shorter leukocyte telomere length is associated with higher risk of infections: a prospective study of 75,309 individuals from...
Risk factors for late infections after allogeneic hematopoietic stem cell transplantation from a matched related donor. Biol ... Blood Marrow Transplant. 2007; 13(11):1304-1312.. OpenUrlCrossRefPubMedWeb of Science ... Association between donor leukocyte telomere length and survival after unrelated allogeneic hematopoietic cell transplantation ... Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres. Blood. 2014 ...
Edwin Pascal Alyea III, M.D. | Harvard Catalyst Profiles | Harvard Catalyst
... comparison with unrelated peripheral blood stem cell transplantation. Biol Blood Marrow Transplant. 2012 Apr; 18(4):565-74. ... Donor-engrafted CHIP is common among stem cell transplant recipients with unexplained cytopenias. Blood. 2017 07 06; 130(1):91- ... Syngeneic donor hematopoietic stem cell transplantation is associated with high rates of engraftment syndrome. Biol Blood ... Reduced-intensity conditioning stem cell transplantation: comparison of double umbilical cord blood and unrelated donor grafts ...
Biol Blood Marrow TransplantHSCTChemotherapyOutcomesPatient'sRecipientsGVHDHematopoietic Stem Cell TranspHaploidenticalGraftComplicationsEngraftmentAcute leukemiaMarrow Transplant ProgramConditioning regimenMortalityAplasticRecipientPediatricLymphomaAutologous transplantationPost transplantTotal-body irradiCancerLeukemiaUmbilical cordClinicalUnrelated-donor hematopoietic stem cell transCancersBiology of Blood and Marrow TransplantationHematologicPBSCPlateletsEmbryonic stemCentersSurvivalOncologyAllogeneic transplantsCord blood transplantsInfusionDonor's stem cellsHaematopoieticChimerismCOMPATIBLE DONORImmuneDisordersRelapseRegistryMyeloablativeMalignancies2017Adult donorBone marrow donor
Biol Blood Marrow Transplant4
- Allogeneic hematopoietic stem cell transplantation (HSCT) is a standard therapeutic intervention for hematological malignancies and several monogenic diseases. (nature.com)
- Recombinant Zoster Vaccine Significantly Reduces the Impact on Quality of Life Caused by Herpes Zoster in Adult Autologous Hematopoietic Stem Cell Transplant Recipients: A Randomized Placebo-Controlled Trial (ZOE-HSCT). (nih.gov)
- One of our approaches includes performing allogeneic hematopoietic stem cell transplantation (HSCT), or the replenishing of blood-forming stem cells from a donor. (mskcc.org)
- Vaccination with autologous myeloblasts admixed with GM-K562 cells in patients with advanced MDS or AML after allogeneic HSCT. (harvard.edu)
- Transplantation of HSC (HSCT) is done in order to re-establish bone marrow and immune system function after being damaged and/or attacked by blood cancer. (thedailystar.net)
- The most common indications for HSCT are blood cancers, mainly acute leukaemia, cancers of the lymphatic tissues (lymphomas) and the antibody-forming blood cells (multiple myeloma). (thedailystar.net)
- HSCT can be broadly divided into autologous transplantation, where patients use their own blood stem cells, and allogeneic transplantation, where stem cells are obtained from a different person. (thedailystar.net)
- Due to the high rates of morbidity and mortality, hematopoietic stem cell transplant (HSCT) is the treatment of choice and leads to resolution of many of the disease complications ( 4 , 5 ). (frontiersin.org)
- Hematopoietic stem cell transplantation (HSCT) has been used in patients with mucopolysaccharidosis in order to correct the enzyme-deficiency. (news-medical.net)
- Matched unrelated donor (MUD) hematopoietic stem cell transplantation (HSCT) is a viable alternative for approximately 75% of patients who will not have an HLA (human leukocyte antigen)-identical sibling. (psychiatryadvisor.com)
- Indications for MUD-HSCT are generally the same as for HLA-matched sibling transplantation. (psychiatryadvisor.com)
- These infections are particularly frequent in patients with hematological malignancies who develop prolonged and severe neutropenia, such as patients with acute myeloid leukemia (AML) and in hematopoietic stem cell transplant (HSCT) recipients (1) . (scielo.br)
- The optimal dose of rabbit antithymocyte globulin (ATG, ImtixSangstat) minimizing infections without increasing graft-versus-host disease (GVHD) is unknown in T cell-replete, G-CSF-primed haploidentical hematopoietic stem cell transplantation (haplo-HSCT). (biomedcentral.com)
- Currently, the strategies for graft-versus-host disease (GVHD) prophylaxis mainly include ex vivo and in vivo T cell depletion (TCD) in haploidentical HSCT (haplo-HSCT) [ 4 , 5 ]. (biomedcentral.com)
- Early study results on a very small number of patients show some promise after non-myeloablative autologous haemopoietic stem-cell transplantation (HSCT) for those with severe disease. (umm.edu)
- Currently, JMML is curable only through hematopoietic stem cell transplantation (HSCT), in which healthy blood stem cells are extracted from a matched donor and intravenously transplanted into the patient. (ucsf.edu)
- Although hematopoietic stem cell transplantation (HSCT) has been considered to be the only way for potential cure of relapsed acute myeloid leukemia (AML), there has been no report on a third HSCT in patients with multiple relapsed AML. (hindawi.com)
- Although there is no available clinical data as references in performing the third allogeneic HSCT currently, this has been performed sporadically at experienced transplant centers as one of options for treatment of patients with multiple relapsed AML, because the HSCT is regarded as the best way to achieve potential cure for refractory or relapsed AML. (hindawi.com)
- A second HSCT was planned with cord blood as the graft source, because disease progression implied a need for an urgent care. (hindawi.com)
- A third HSCT using cord blood as the graft source was planned in non-CR status after treatment with a hypomethylating agent, azacitidine, [ 1 , 2 ] at the age of 53 again, because the patient had no significant comorbidities. (hindawi.com)
- Allogeneic haematopoietic stem cell transplantation (HSCT) offers a potential cure for a variety of malignant and non-malignant conditions. (pubmedcentralcanada.ca)
- However, regimen-related toxicity, graft-versus-host disease (GVHD), and opportunistic infections ( Kernan et al , 1993 ) still remain the major cause of morbidity and mortality after unrelated donor (URD) allogeneic HSCT. (pubmedcentralcanada.ca)
- In addition to identifying patients and transplant-related prognostic factors, identifying favourable factors in the donor may aid in donor selection and may improve outcomes after HSCT. (pubmedcentralcanada.ca)
- Data addressing this issue in the unrelated donor HSCT setting are scarce, however Keen et al (2004) have reported association of TNF-α and IL-10 genotypes with toxicity after unrelated donor transplant. (pubmedcentralcanada.ca)
- Taken together, these data suggest that non-HLA genetic variation influences risk of GVHD and HSCT mortality, and that it might be possible to predict HSCT outcome from a profile of donor or recipient risk factors, including cytokine polymorphisms. (pubmedcentralcanada.ca)
- The registry collects data from all hospitals in Australia and New Zealand in which haemopoietic stem cell transplantation (HSCT) is performed. (mja.com.au)
- Natural killer (NK) cells are one of the first cells to recover following allogeneic hematopoietic stem cell transplantation (HSCT), and are believed to play an important role in facilitating engraftment or preventing post-transplant infection and tumor recurrence. (jcancer.org)
- In particular, the ability of NK cells to reduce the risk of graft versus host disease (GVHD) and increase the graft versus leukemia effect (GVL) in the setting of human leukocyte antigen (HLA)-haploidentical HSCT highlights their clinical potentials. (jcancer.org)
- As one of the first lymphocyte populations to recover 5 , 6 , NK cells play an important role in immune reconstitution following HSCT. (jcancer.org)
- Hematopoietic stem cell transplantation (HSCT) has become an accepted and widely used treatment option for defined malignant and nonmalignant diseases. (wiley.com)
- Initially, given the considerable transplant-related mortality (TRM), which was partly associated with myeloablative conditioning (MAC), HSCT was restricted to younger patients. (wiley.com)
- Long-term control of recurrent or refractory viral infections after allogeneic HSCT with third-party virus-specific T cells. (edu.au)
- 14 - 17 Only allogeneic hematopoietic stem cell transplantation (HSCT), however, can cure the disease. (aappublications.org)
- Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at high risk of readmission for complications. (springer.com)
- Japanese Data Center for Hematopoietic Cell Transplantation (JDCHCT) collects and analyses recipient-, donor-, and outcome- information of the hematopoietic stem cell transplantation (HSCT) in Japan. (omicsonline.org)
- Our activities contribute to gain precise activity information of HSCT in Japan, which is useful for patients who are suffering from hematology-oncology or other diseases requiring HSCT and also for transplant centres. (omicsonline.org)
- The JDCHCT performs data collection, data management, and statistical analyses to promote clinical research in HSCT.HSCT recipient-, donor- and outcome- data are collected by using Transplant Registry Unified Management Program (TRUMP) in collaboration with Japan Society for Hematopoietic Cell Transplantation, Japan Society for Paediatric Hematology and Oncology, Japan Marrow Donor Program, Cord Blood Banks and Japanese Red Cross Society. (omicsonline.org)
- 1 Despite the remarkable improvements in medical therapy for hemoglobinopathies, 3 2 hematopoietic stem cell transplantation (HSCT) still remains the only available curative approach. (haematologica.org)
- 5 4 There are a number of possible reasons for this difference, including a lack of consensus about the indications and time point for HSCT in SCD, and the low chance of identifying an unrelated donor for SCD patients. (haematologica.org)
- Giving chemotherapy and total-body irradiation (TBI) before a donor PBSC transplant helps stop the growth of cancer cells. (clinicaltrials.gov)
- The patient receives chemotherapy to kill blood-forming cells. (cancer.gov)
- A type of chemotherapy used to kill cancer cells by interfering with cancer cell division. (lls.org)
- It uses high doses of chemotherapy and sometimes radiation to "turn off" a patient's immune system so that the donor cells are not rejected. (lls.org)
- Patients on this study will be given standard transplant therapy with either high doses of chemotherapy drugs or lower doses of chemotherapy drugs, depending on their disease. (clinicaltrials.gov)
- This may happen if the chemotherapy and radiation given before the transplant were not able to fully shut down the patient's immune system. (mskcc.org)
- In this condition, the cells that line the mouth and intestinal tract are destroyed by the high-dose chemotherapy or radiation therapy given before the transplant. (mskcc.org)
- Cancer can return if the chemotherapy and radiation given before the transplant did not get rid of all the cancer cells. (mskcc.org)
- PURPOSE: Phase II trial to study the effectiveness of chemotherapy followed by peripheral stem cell transplantation in treating patients who have metastatic or recurrent kidney cancer. (bioportfolio.com)
- RATIONALE: Giving low doses of chemotherapy, such as fludarabine, and radiation therapy before a donor bone marrow transplant helps stop the growth of cancer cells. (bioportfolio.com)
- In both types of transplantation, the patient's cancerous bone marrow is destroyed with high doses of chemotherapy or radiation. (news-medical.net)
- The rationale underlying autologous transplantation is to deliver high doses of chemotherapy (with or without radiotherapy). (thedailystar.net)
- Whereas anti-tumour effects rely solely on high-doses of chemotherapy in autologous transplants, allogeneic HSC may also have beneficial immune activity that kills tumour/leukaemia. (thedailystar.net)
- About mini allogeneic transplant This is an allogeneic transplants with reduced intensity conditioning, using less toxic doses of chemotherapy to prepare for the transplant. (lymphomation.org)
- Evaluating an experimental therapy, Dr. Symons is pairing donor lymphocytes (white blood cells that activate the body's immune system) with chemotherapy to determine if this combination will "awaken" patients' immune systems to the danger of existing cancer cells and, in turn, elicit an immune response. (hopkinsmedicine.org)
- But almost all patients have a half-matched donor: a parent, sibling, or child," adds Dr. Symons, who is examining ways to reduce BMT-related complications ordinarily associated with half-matched donors after ablative (high dose) chemotherapy. (hopkinsmedicine.org)
- A phase III trial in 405 adults with heavily pretreated B-cell precursor ALL found that treatment with blinatumomab (n = 271) resulted in significantly longer overall survival than treatment with chemotherapy (n = 134). (medscape.com)
- Giving chemotherapy before a donor peripheral blood stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. (cancer.gov)
- The primary modes of therapy are intensive chemotherapy, transfusion and antibiotic support for immunosuppression and hematopoietic stem cell transplantation. (hamiltonhealthsciences.ca)
- Patients who undergo chemotherapy or radiation treatment may also need a transplant of healthy stem cells to help heal and re-boost their immune system. (blood.ca)
- For AML with "good-risk" chromosome changes, additional chemotherapy or an autologous transplant is usually recommended. (bio-medicine.org)
- Complications of Bone Marrow or Hematopoietic stem cell transplantation include graft-versus-host disease, graft failure, increased susceptibility to infections and complications due to the chemotherapy and /or radiation used prior to the procedure. (medindia.net)
- Chemotherapy including immunosuppressive drugs and /or radiation used prior to transplantation often cause adverse effects like nausea, vomiting and skin redness. (medindia.net)
- Shortly before your child's stem cell transplant, your child will undergo chemotherapy and/or radiation. (stanford.edu)
- This was based on observations that donor derived cells posses the ability eliminate host cancer cells in conjunction with chemotherapy and radiation. (isracast.com)
- For his part, Dr. Gerson, an expert in stem cells and DNA repair, has identified a gene therapy that creates drug-resistant stem cells capable of selectively repopulating the recipient without the need for high-dose, toxic chemotherapy. (uhhospitals.org)
- Jeanine Walsh was recovering from chemotherapy this week, and will have another round of aggressive chemo to prepare for transplant. (cbslocal.com)
- RATIONALE: Drugs used in chemotherapy, such as treosulfan and fludarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. (drugpatentwatch.com)
- If your cancer is not responding to chemotherapy or radiation, you may receive bone marrow transplantation or peripheral stem cell transplantation. (doctors-hospital.net)
- For each of these therapies, chemotherapy drugs are given first to rid the body of the cancer cells. (doctors-hospital.net)
- The chemotherapy kills healthy cells as well. (doctors-hospital.net)
- For a stem cell transplant, stem cells from the peripheral blood or bone marrow are collected (harvested) and placed in frozen storage prior to treatment of the cancer with high-dose chemotherapy. (doctors-hospital.net)
- Conventional chemotherapy drugs kill cancer cells by working on the "machinery" inside of cells and causing the cells to die. (northside.com)
- Prior to CAR T-cell infusion, the patient receives disease-specific chemotherapy, which creates space within the immune system to allow the infused reprogrammed CAR T-cells to grow and multiply. (northside.com)
- Her first chemotherapy treatment put the cancer in remission, but her doctor at the time described her situation somewhat ominously: "One way the doctor explained it to me was that the chemo is just killing the tip of the iceberg of your leukemia cells," said Day, now 31. (fredhutch.org)
- Treatments for leukemia include chemotherapy (major treatment modality for leukemia), radiation therapy, biological therapy , targeted therapy, and stem cell transplant. (rxlist.com)
- Chemotherapy is the administration of drugs that kill rapidly dividing cells such as leukemia or other cancer cells. (rxlist.com)
- Some side effects from chemotherapy drugs include hair loss , nausea , vomiting, mouth sores , loss of appetite, tiredness, easy bruising or bleeding, and an increased chance of infection due to the destruction of white blood cells. (rxlist.com)
- At the time of transplant 12 patients (29%) were in complete remission, 18 had chemotherapy-sensitive disease, and 12 patients had chemotherapy-resistant disease. (unboundmedicine.com)
- When used to treat cancers such as non-Hodgkin's lymphoma and multiple myeloma, high-dose chemotherapy also destroys normal cells such as the HSCs and HPCs in the bone marrow. (nih.gov)
- To replenish the lost cells, HSCs and HPCs are routinely harvested from a donor's or patient's blood, and then transplanted back into the patient at the conclusion of the chemotherapy procedure to repopulate the bone marrow. (nih.gov)
- The success of this approach depends on several factors including underlying disease and its sensitivity to GVT induction, disease burden, timing of relapse in relation to SCT, presence of comorbid disease, donor availability and whether DLI is preceded by chemotherapy. (renalandurologynews.com)
- Alternative treatment options for relapse after SCT are very limited and poorly studied but include second SCT from the same or different donor, disease specific chemotherapy agents alone, or the testing of novel agents. (renalandurologynews.com)
- This agent offers improved tolerability compared to conventional chemotherapy, and may increase the immunogenicity of malignant cells. (renalandurologynews.com)
- We studied the clinical outcomes of 171 adults with hematologic malignancies who received unrelated cord blood transplantation (CBT) as a primary unrelated stem-cell source (n = 100), or bone marrow transplant (BMT) or peripheral blood stem-cell transplant (PBSCT) from related donors (n = 71, 55 BMT and 16 PBSCT). (elsevier.com)
- Early E. casseliflavus gut colonization and outcomes of allogeneic hematopoietic cell transplantation. (nih.gov)
- Epidemiology and Outcomes of Clostridium difficile Infection in Allogeneic Hematopoietic Stem Cell and Lung Transplant Recipients Transplant Infectious Disease In press 2017. (upenn.edu)
- Ongoing advances in stem cell transplant are expanding its availability and improving outcomes for patients, young and old. (uchospitals.edu)
- Outcomes appear at least equivalent to those seen in contemporaneous patients who underwent transplantation from MUD. (unboundmedicine.com)
- Eapen and her colleagues compared the outcomes of 143 PBSC and 630 bone marrow transplants in patients with acute leukemia aged 8-20 years who were transplanted between 1995 and 2000.This analysis was performed with data reported to the International Bone Marrow Transplant Registry (IBMTR). (news-medical.net)
- Overall mortality was also higher after PBSC transplants - 57%, versus 44% after bone marrow transplants.The risk of leukemia recurrence after transplantation did not differ.These results persisted after controlling for relevant risk factors that may affect outcomes after transplantation. (news-medical.net)
- Candidate SNP associations with survival outcomes after URD transplant are most likely false-positive findings. (bloodjournal.org)
- Multiple candidate gene-association studies of non-HLA single-nucleotide polymorphisms (SNPs) and outcomes after blood or marrow transplant (BMT) have been conducted. (bloodjournal.org)
- For over a decade, researchers have conducted candidate gene-association studies of patient survival outcomes after allogeneic blood or marrow transplant (BMT). (bloodjournal.org)
- Incidence, Predictors, and Outcomes of Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation. (harvard.edu)
- HLA-C antigen-mismatched unrelated PBSC donors were associated with worse outcomes compared with 8/8 HLA-matched donors. (lymphomation.org)
- Outcomes of measurable residual disease in pediatric acute myeloid leukemia pre- and post-hematopoietic stem cell transplant: validation of difference from normal flow cytometry with chimerism studies and Wilms tumor 1 gene expression. (stembook.org)
- An Analysis of the Effect of Race, Socioeconomic Status and Center Size on Unrelated NMDP Donor Outcomes: Donor Toxicities are More Common at Low Volume Bone Marrow Collection Centers. (stembook.org)
- Transplant outcomes from MUDs have improved over time and, with fully matched donors, outcomes are now comparable to matched sibling transplantation. (psychiatryadvisor.com)
- There he developed new therapy models to be used for improving bone marrow transplantation outcomes. (isracast.com)
- Mayo Clinic doctors and scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
- In fact, the comparison of 190 patients receiving cord-blood transplants with 123 patients receiving transplants from the "gold standard" of matched sibling donors showed no difference in survival outcomes between these two approaches, with significantly fewer complications due to chronic graft-versus-host disease in patients receiving transplants from cord blood. (brightsurf.com)
- This means the UH pediatric bone marrow transplant program exceeds national standards in patient care, laboratory practices and patient outcomes. (uhhospitals.org)
- The bone marrow transplant program offers extraordinary outcomes. (uhhospitals.org)
- In this review, we summarize the recent advances related to the mechanisms, functions, and future clinical prospects of NK cells that can impact post-transplant outcomes. (jcancer.org)
- The researchers reviewed outcomes for 582 patients who'd received stem cell transplants at the Hutch from 2006, when the institute's Cord Blood Program launched, to 2014. (fredhutch.org)
- Patients going into transplant with minimal residual disease, they have very dismal outcomes," said Fred Hutch transplantation researcher Dr. Filippo Milano , lead author of the NEJM paper. (fredhutch.org)
- But this study showed that such patients who received a cord blood transplant had better outcomes and a lower relapse rate than those who received stem cells from an adult unrelated donor, Milano said. (fredhutch.org)
- For the other two-thirds of the patients, those with no minimal residual disease, cord blood transplants and traditional transplants had very similar outcomes. (fredhutch.org)
- Limited studies have reported on outcomes for lymphoid malignancy patients receiving alternative donor allogeneic stem cell transplants. (unboundmedicine.com)
- Predictors and impact of thirty-day readmission on patient outcomes and health care costs after reduced-toxicity conditioning allogeneic hematopoietic cell transplantation. (springer.com)
- each play an important role in society by reporting the number and outcomes of transplantations and contributing new findings obtained from studies on individual topics. (omicsonline.org)
- These observations are highlighted in a large study by the European Group for Blood and Marrow Transplant, which reported outcomes of 399 patients with relapsed AML after SCT who received (n=171) and did not receive (n=228) DLI. (renalandurologynews.com)
- The use of hematopoietic stem cell transplantation has been increasing, and outcomes today have substantially improved compared with the past three decades. (haematologica.org)
- We are excited about the potential of ORENCIA to improve outcomes for patients receiving unrelated stem cell transplants. (pipelinereview.com)
- It may also prevent the patient's immune system reject the donor's stem cells. (clinicaltrials.gov)
- When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. (clinicaltrials.gov)
- A treatment that uses healthy donor stem cells to restore a patient's marrow and blood cells. (lls.org)
- Graft-versus-host disease (GVHD) can happen if white blood cells that have formed from the donor's stem cells recognize the patient's cells and tissues as foreign and attack them. (mskcc.org)
- Sometimes, the donor's stem cells fail to grow and replace the patient's blood cells after the transplant. (mskcc.org)
- The most common cause is that the patient's immune system recognizes the donor's cells as foreign and attacks them. (mskcc.org)
- Complications come up during the time before a patient's blood cell production returns to normal. (mskcc.org)
- This section describes the 4 components of allogeneic transplantation - conditioning, transplantation, engraftment and immunoreconstitution ( Fig. 2 ) - and provides information about the patient's hospital stay and the risks associated with this type of transplantation. (cmaj.ca)
- Our patients see physicians who are experts not only in transplantation but also in the patient's specific cancer or blood disease, such as leukemia, lymphoma and multiple myeloma. (uchospitals.edu)
- It is important to note that the current study addresses transplants from donors only, not "autologous" PBSC transplants, in which stem cells are taken from the patient's own blood.This approach has been proven safe among adults and children, and is widely used. (news-medical.net)
- A T-cell depleted transplant reduces the risk of graft-versus-host disease , in which the transplanted cells recognize the patient's own cells as foreign and produce an inflammatory reaction. (mskcc.org)
- The reinfusion of the patient's own stem cells acts to rescue the bone marrow from toxicity. (thedailystar.net)
- In the case of allogeneic transplant, the patient's donor will also have to undergo an assessment. (thedailystar.net)
- Using living cells to replace, regenerate or enhance a healing process in the patient's body is facilitated in large part by UH Seidman Cancer Center's Cellular Therapy Service. (uhhospitals.org)
- Stem cell transplantation for Hodgkin's disease usually involves harvesting the patient's stem cells, from the bone marrow or blood, rather than from a donor. (doctors-hospital.net)
- Current transplantation therapies rely on the infusion of donor stem cells into a patient's bone marrow to generate new, healthy blood cells without disease. (scienceblog.com)
- One means of circumventing this immune rejection problem would be to generate hematopoietic stem cells, or HSCs, using the patient's own precursor cells. (scienceblog.com)
- In addition to showing a decrease in the chance of graft-versus-host disease, which develops when a transplanted blood system attacks a patient's tissues, the study shows a slightly lower rate of relapse in these patients undergoing transplant with cord blood. (brightsurf.com)
- Umbilical cord blood, which is banked for public use at designated centers around the world, is rich in stem cells, which can repopulate a patient's blood system. (brightsurf.com)
- For the treatment of congenital diseases, the patient's own cord blood cannot be used because the same disease also affects the stem cells located there. (womenfitness.net)
- Autologous transplantation, where the patient's own cord blood stem cells are used in treatment. (womenfitness.net)
- All of these diseases have been treated with allogeneic cord blood transplants--cases where blood has been collected from a familial or unrelated donor, as opposed to autologous transplants, in which the patient's own blood is utilized. (scientificamerican.com)
- Treatment will typically depend upon the type of leukemia, the patient's age and health status, as well as whether or not the leukemia cells have spread to the cerebrospinal fluid. (rxlist.com)
- GvHD occurs when the donor T-cells also recognize the patient's healthy cells as foreign and start attacking healthy tissues and organs. (pipelinereview.com)
- Thus, we conducted a retrospective analysis of recipients of single-unit CBT with pretransplant anti-HLA antibodies using the database of Japan Society for Hematopoietic Cell Transplantation (JSHCT). (nature.com)
- Infections in Hematopoietic Cell Transplant Recipients: Results From the Organ Transplant Infection Project, a Multicenter, Prospective, Cohort Study Open Forum Infect Dis 4(2), March 2017. (upenn.edu)
- Recipients of stem cell transplants may be severely immunocompromised for many months after transplantation, especially if they are still taking immunosuppressive drugs. (cmaj.ca)
- In this article we aim to familiarize primary care practitioners with some of the basics of allogeneic and autologous transplantation, as well as issues relevant to the care of transplant recipients over the short and the long term. (cmaj.ca)
- Replication and validation of these SNP associations were performed using DISCOVeRY-BMT (Determining the Influence of Susceptibility COnveying Variants Related to one-Year mortality after BMT), a well-powered genome-wide association study consisting of 2 cohorts, totaling 2888 BMT recipients with acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndrome, and their HLA-matched unrelated donors, reported to the Center for International Blood and Marrow Transplant Research. (bloodjournal.org)
- Surprisingly, the rate of early engraftment of donor-derived BM cells in recipients co-transplanted with CXCR4-MSCs was slightly lower than in the absence of MSCs on day 7. (springer.com)
- In a recent study of allogeneic hematopoietic cell transplantation for severe aplastic anemia, long donor leukocyte telomere length was associated with improved survival in the recipients. (haematologica.org)
- Further studies are needed to determine whether risk of infections in allogeneic hematopoietic cell transplantation recipients can be reduced by considering donor leukocyte telomere length when selecting donors. (haematologica.org)
- The program includes a stem cell collection center for transplant recipients and for Canadian Blood Services donors. (hamiltonhealthsciences.ca)
- The study protocol was approved by the local ethics committee review board, and written informed consent was obtained from the donors and recipients in accordance with the Declaration of Helsinki before the initiation of the study. (biomedcentral.com)
- Enhanced antiviral immunity was also seen in WT transplant recipients engrafted with VIP-KO hematopoietic cells, indicating that VIP synthesized by neuronal cells did not suppress immune responses. (jimmunol.org)
- A non-bone marrow ablative regimen consisting of total lymphoid irradiation (TLI) and anti-thymocyte globulin (ATG) will be used to condition the recipients for transplantation. (clinicaltrials.gov)
- This relates directly to cell dose, which is calculated on the recipients' weight. (mja.com.au)
- The group included 1,243 adult-donor transplant recipients and 101 unrelated cord blood transplant recipients. (fredhutch.org)
- They identified 19 cases of HHV-6-PALE that occurred in 10 percent of the cord blood transplant recipients and 0.7 percent of adult-donor transplant recipients. (fredhutch.org)
- None of the adult-donor transplant recipients died from the syndrome. (fredhutch.org)
- Pulmonary Cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: implications for the diagnosis of CMV pneumonia. (stembook.org)
- Validation of a multivariable prediction model for post-engraftment invasive fungal disease in 465 adult allogeneic hematopoietic stem cell transplant recipients. (stembook.org)
- Middleton et al (1998) showed that the homozygous d3 genotype of the tumour necrosis factor (TNF)-α microsatellite, and the presence of IL10 alleles with greater numbers of dinucleotide repeats were preferentially associated with grade III/IV GVHD in sibling transplant recipients. (pubmedcentralcanada.ca)
- In studies of 993 recipients of matched sibling donor transplant, Lin et al ( 2003 , 2005 showed that interleukin 10 (IL-10) genotype of the recipient and IL-10 receptor genotype of the donor modified the risk of GVHD. (pubmedcentralcanada.ca)
- 2,3 Furthermore, recipients have a higher nonrelapse mortality if CMV reactivation occurs less than 100 days after transplantation. (hematology.org)
- Despite these advances, several studies have shown that recipients who are CMV-seropositive remain at risk for worse OS and increased transplant-related mortality. (hematology.org)
- Graft-versus-host disease prophylaxis with tacrolimus and mycophenolate mofetil in HLA-matched nonmyeloablative transplant recipients is associated with very low incidence of GVHD and nonrelapse mortality. (springer.com)
- The core activities of JSHCT are consisted of organizing annual congress, publishing quarterly JSHCT Letters, managing the data centres for transplant patient and donor registration, publishing Annual Report of Nationwide Survey for transplant recipients, promoting more than 20 working groups, steering more than 10 committees and publishing multiple guidelines for hematopoietic stem cell transplantation. (omicsonline.org)
- This phase II trial studies donor atorvastatin treatment for the prevention of severe acute graft-versus-host disease (GVHD) in patients undergoing myeloablative peripheral blood stem cell (PBSC) transplantation. (clinicaltrials.gov)
- I. To assess whether 2 weeks of donor statin treatment reduces the risk of severe acute GVHD. (clinicaltrials.gov)
- We analyzed the hematologic recovery, and risks of graft-versus-host disease (GVHD), transplantation-related mortality (TRM) and relapse, and disease-free survival (DFS) using Cox proportional hazards models. (elsevier.com)
- Risk factors for acute GVHD and survival after hematopoietic cell transplantation. (nature.com)
- Graft-versus-host disease (GVHD) is a condition that results from a reaction of transplanted donor T-lymphocytes against the body and organs of the patient receiving the transplanted cells. (clinicaltrials.gov)
- GVHD can make patients very sick, and have GVHD can make it more likely that patients will not survive their transplant. (clinicaltrials.gov)
- In this study, the investigators are offering to treat the donor peripheral blood stem cells in the hope that it will make it less likely for the patient who receives them from having GVHD. (clinicaltrials.gov)
- Patients on this study are being offered an experimental treatment involving the use of the CliniMACS® Reagent System (Miltenyi Biotec, Germany), a CD34+ selection device to remove T-cells from the peripheral blood stem cell transplant in order to decrease the risk of acute and chronic GVHD. (clinicaltrials.gov)
- T-cells are the cells which are responsible for graft versus host disease (GVHD). (clinicaltrials.gov)
- Factors such as the age and gender of the patient and the donor and the intensity of the treatments that the patient has before transplantation also determine the risk of GVHD. (mskcc.org)
- Patients maintaining a mixed chimerism with no evidence of grade III or IV GVHD receive donor lymphocyte infusions (DLI) on days 60, 90, and 120. (bioportfolio.com)
- Grade II to IV acute GVHD was seen less often after haplo compared with MUD transplantation (43% versus 63%, P = .049), as was moderate-to-severe chronic GVHD (22% versus 58%, P = .003). (unboundmedicine.com)
- Disease relapse and graft- versus -host disease (GVHD) impact the length and quality of life after allogeneic hematopoietic cell transplantation (HCT). (haematologica.org)
- Removing T-cells may help stop a side effect called Graft-Versus-Host Disease (GVHD). (bioportfolio.com)
- Accurate determination of immune system compatibility is vital to minimise graft failure and lethal attack from donor cells against recipient's normal tissues (graft-versus-host disease or GvHD). (thedailystar.net)
- However, the higher T cell content of PBSC may also lead to increased incidence and severity of acute and chronic graft-versus-host disease (GVHD). (knowcancer.com)
- This is because there is tolerance for HLA disparity, postulated to be due to the relative immunological naivety of UCB, which results in less graft versus host disease (GVHD), a major limitation of transplanting unrelated donor cells. (mja.com.au)
- Graft versus host disease (GvHD) remains a major complication after allogeneic hematopoietic stem cell transplantation and is the main cause of transplant-related mortality. (wiley.com)
- Both hematopoietic cells and cells that form the hematopoietic stem and progenitor cell niche have been identified as targets of GvHD. (wiley.com)
- GvHD is mediated by alloreactive donor lymphocytes that reside in the graft and target nonmalignant host tissues. (wiley.com)
- There appear to be several advantages to using stem cells from umbilical cord blood, including rapid availability, potential to expand the ethnic diversity of the donor pool (minorities are vastly underrepresented in bone marrow donor pools), no donor risk, less likelihood of viral contamination and less risk of graft-versus-host disorder (GVHD). (scientificamerican.com)
- GVHD is a significant consideration because stem cells from a donor's bone marrow often recognize the host as foreign, resulting in complications after transplantation. (scientificamerican.com)
- Cord blood stem cells are potentially less immunologically active and may pose less risk of GVHD than stem cells from bone marrow. (scientificamerican.com)
- All patients received fludarabine/melphalan/antithymocyte globulin conditioning regimen and post-transplant graft-versus-host disease (GVHD) prophylaxis with tacrolimus and mycophenolate mofetil. (unboundmedicine.com)
- PRINCETON, NJ, USA I December 04, 2019 I Bristol-Myers Squibb Company (NYSE: BMY) today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation for ORENCIA ® (abatacept) for the prevention of moderate to severe acute graft-versus-host disease (GvHD) in hematopoietic stem cell transplants from unrelated donors. (pipelinereview.com)
- There are no approved therapies for the prevention of acute GvHD, a potentially life-threatening medical complication that can impact patients receiving such transplants for the treatment of certain genetic diseases and hematologic cancers. (pipelinereview.com)
- However, some of their benefit is offset by the occurrence of severe acute GvHD, which impacts up to 40 percent of patients receiving stem cell transplants from unrelated donors with a mismatch in genes called human leukocyte antigens (HLA). (pipelinereview.com)
- 2 These transplants are associated with a high rate of transplant-related mortality stemming largely from severe acute GvHD. (pipelinereview.com)
- A therapy that lowers the risk of GvHD in unrelated stem cell transplants would potentially allow more patients to receive a transplant, which typically is the last option to treat hematologic cancers after other therapies have been used unsuccessfully. (pipelinereview.com)
- This Phase 2 trial assessed the impact of ORENCIA on the prevention of severe acute GvHD, when added to a standard GvHD prophylactic regimen administered to patients with hematologic malignancies receiving a stem cell transplant from an unrelated, HLA-matched or mismatched donor. (pipelinereview.com)
- GvHD after a hematopoietic stem cell transplant occurs when transplanted donor T-cells recognize antigenic differences between the donor and the recipient and attack the recipient's healthy tissue and organs. (pipelinereview.com)
- 1 Acute GvHD impacts up to 40 percent of patients who receive stem cell transplants from unrelated and HLA-mismatched donors. (pipelinereview.com)
Hematopoietic Stem Cell Transp3
- Is There Any Reason to Prefer Cord Blood Instead of Adult Donors for Hematopoietic Stem Cell Transplants? (frontiersin.org)
- The EBV-driven lymphoproliferative disease along with the infection history in the brother led to the diagnosis of DOCK8 deficiency and curative hematopoietic stem cell transplants. (frontiersin.org)
- One million hematopoietic stem-cell transplants: a retrospective observational study. (springer.com)
- High risk of graft failure in patients with anti-HLA antibodies undergoing haploidentical stem-cell transplantation. (nature.com)
- Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with secondary acute myeloid leu. (nih.gov)
- Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with secondary acute myeloid leukemia, a comparative study from Eurocord and the ALWP EBMT. (nih.gov)
- Cord blood transplantation (UCBT) and non-T-cell-depleted stem cell transplantation from haploidentical donors (HAPLO) are both strategies that have shown encouraging results in patients who do not have an human leukocyte antigen (HLA)-matched sibling or unrelated donor. (nih.gov)
- These results indicate that HAPLO is associated with better GRFS and lower aGvHD compared to UCBT in patients with sAML and that UCBT can be a valid alternative for sAML patients who lack a matched sibling, a proper haploidentical or an unrelated donor. (nih.gov)
- Selection of optimal alternative graft source: mismatched unrelated donor, umbilical cord blood, or haploidentical transplant. (nature.com)
- Options for individuals lacking a related donor include haplo-cord transplants -- a combination of donated umbilical cord blood stem cells and half-matched (haploidentical) cells from a related donor. (uchospitals.edu)
- We enrolled 30 patients on a prospective phase II trial utilizing a total body irradiation (TBI)-based myeloablative preparative regimen (fludarabine 30 mg/m2/day × 3 days and TBI 150 cGy twice per day on day -4 to -1 [total dose 1200 cGy]) followed by infusion of unmanipulated peripheral blood stem cells from a haploidentical family donor (haplo). (unboundmedicine.com)
- Improved survival with inhibitory Killer Immunoglobulin Receptor (KIR) gene mismatches and KIR haplotype B donors after nonmyeloablative, HLA-haploidentical bone marrow transplantation. (hopkinsmedicine.org)
- Determine the safety and efficacy of non-T-cell depleted, HLA-haploidentical related donor hematopoietic stem cell transplantation after a reduced-intensity conditioning regimen comprising busulfan, fludarabine phosphate, anti-thymocyte globulin, and methylprednisolone in patients with hematologic cancer, recurrent or metastatic solid tumors, or other diseases. (knowcancer.com)
- Comparison of transfusion requirements in adult patients undergoing haploidentical or single unit umbilical cord blood stem cell transplantation. (stembook.org)
- We have previously described combining CD34-selected haploidentical grafts with umbilical cord blood (haplo-cord) to accelerate neutrophil and platelet engraftment. (unboundmedicine.com)
- It can be used after related, unrelated and haploidentical transplants but is not available after unrelated umbilical cord transplants. (renalandurologynews.com)
- Graft failure (GF) remains a major complication of cord blood transplantation (CBT). (nature.com)
- Ozdemir ZN, Civriz Bozdag S. Graft failure after allogeneic hematopoietic stem cell transplantation. (nature.com)
- Long-term follow-up of patients who experienced graft failure postallogeneic progenitor cell transplantation. (nature.com)
- Peripheral blood as a preferable source of stem cells for salvage transplantation in patients with graft failure after cord blood transplantation: a retrospective analysis of the registry data of the Japanese Society for Hematopoietic Cell Transplantation. (nature.com)
- Complement-binding donor-specific anti-HLA antibodies and risk of primary graft failure in hematopoietic stem cell transplantation. (nature.com)
- Efforts to increase stem cell content or engraftment rate of the graft by ex vivo expansion, modulation by molecules such as fucose, prostaglandin E2 derivative, complement CD26 inhibitors, or CXCR4/CXCL12 axis have been able to accelerate engraftment speed and rate. (frontiersin.org)
- However, this approach has limitations related to lack of a suitable donor, graft-versus-host disease and infectious complications due to immune suppression. (nature.com)
- The risk of graft failure generally lasts about two to four weeks after the transplant. (mskcc.org)
- If there is a graft failure, doctors may recommend transplanting more donor stem cells, if they are available. (mskcc.org)
- In the allogeneic setting, graft-versus-host disease may also develop, making post-transplant management complex. (cmaj.ca)
- Sirolimus, tacrolimus, and low-dose methotrexate as graft-versus-host disease prophylaxis in related and unrelated donor reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation. (harvard.edu)
- It is critical that this question be carefully studied by prospectively identifying the patients, diseases, and clinical settings in which clinical benefit is likely to be observed.Until then, patients and families need to be informed about the risks of transplant-related morbidity, including chronic graft-versus-host disease and higher risk of mortality. (news-medical.net)
- Comparison of Tacrolimus and Sirolimus (Tac/Sir) versus Tacrolimus, Sirolimus, and mini-methotrexate (Tac/Sir/MTX) as acute graft-versus-host disease prophylaxis after reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation. (harvard.edu)
- A Bortezomib-Based Regimen Offers Promising Survival and Graft-versus-Host Disease Prophylaxis in Myeloablative HLA-Mismatched and Unrelated Donor Transplantation: A Phase II Trial. (harvard.edu)
- We previously reported that bone marrow grafts from matched sibling donors resulted in best graft- versus -host disease-free, relapse-free survival at 1-year post allogeneic hematopoietic cell transplantation. (haematologica.org)
- In adults, bone marrow from matched sibling donors (n=123) had best graft- versus -host disease-free, relapse-free survival at 1- and 2-years, compared with peripheral blood stem cell from matched sibling donors (n=540) or other graft/donor types. (haematologica.org)
- In multivariate analysis, peripheral blood stem cells from matched sibling donors resulted in a 50% increased risk of events contributing to graft- versus -host disease-free, relapse-free survival at 1- and 2-years than bone marrow from matched sibling donors. (haematologica.org)
- With limited numbers of peripheral blood stem cell grafts in pediatric patients (n=12), graft- versus -host disease-free, relapse-free survival did not differ between bone marrow and peripheral blood stem cell graft from any donor. (haematologica.org)
- While not all patients have a matched sibling donor, graft- versus -host disease-free, relapse-free survival may be improved by the preferential use of bone marrow for adults with malignant diseases. (haematologica.org)
- Alternatively, novel graft- versus -host disease prophylaxis regimens are needed to substantially impact graft- versus -host disease-free, relapse-free survival with the use of peripheral blood stem cell. (haematologica.org)
- The incidence of graft-versus-host disease in unrelated stem cell transplantation is recorded. (bioportfolio.com)
- In the case of transplants using HSC derived from other people, the conditioning therapy also helps reduce the risk of the recipient's body killing or rejecting the incoming donor stem cells (graft rejection). (thedailystar.net)
- adoptive immunotherapy', because the donor immune cells act against the disease - a graft versus lymphoma affect. (lymphomation.org)
- This approach shifts tumor eradication to the graft-vs-host immune response directed against minor histocompatibility antigens expressed on tumor cells. (lymphomation.org)
- Graft-versus-host disease occurs due to a reaction between the white blood cells of the donor bone marrow and the recipient s cells. (medindia.net)
- When the graft fails to take up in the donor and produce new blood cells, it results in graft failure. (medindia.net)
- The extent of donor mismatch will often influence the timing of a MUD transplant, particularly in patients with nonmalignant disease who cannot benefit from the compensatory increase in graft-versus-malignancy effect arising from the mismatch. (psychiatryadvisor.com)
- Also, there is a greater risk of graft rejection in mismatched unrelated donor transplants for non-malignant indications such as severe aplastic anemia in which patients are often allo-immunized. (psychiatryadvisor.com)
- The trial will include evaluation of patient and donor quality of life, composition of the graft, and immune reconstitution. (knowcancer.com)
- In a mouse model of allogeneic BM transplantation, DC that were differentiated in the presence of VIP, and then transplanted along with BM cells and splenic T cells, induced the generation of regulatory T cells and protected mice from acute graft versus host disease ( 12 ). (jimmunol.org)
- We also have one of the largest apheresis facilities in the country (performing removal of stem cells for harvesting and transplantation), and one of the strongest photophoresis programs-a therapy to treat complications after transplant, such as graft-versus-host disease (a complication in which immune cells from the donor attack tissues of the recipient, causing inflammation and other symptoms). (hackensackumc.org)
- The mycophenolate mofetil will be stopped at approximately 1 month post-transplantation and the cyclosporine will be tapered beginning at 2 months post-transplantation and discontinued by 6 months in the presence of stable blood chimerism and the absence of graft-versus-host disease. (clinicaltrials.gov)
- In 1986 the first transplants were done by the removal of the bone marrow components which caused significant graft-versus-host complications. (isracast.com)
- Advantages of UCB include no risk to the donor, reduced risk of viral contamination of the graft, rapid donor identification, and faster availability ( Box 3 ). (mja.com.au)
- The main disadvantage of UCB is the inferior speed of haematopoietic cell recovery and higher graft failure rates compared with bone marrow. (mja.com.au)
- She was treated with a toxicity reduced conditioning regimen and received direct intrabone cord blood transplantation (CBT) using a single unit of 5/6 HLA-matched cord blood as a graft source. (hindawi.com)
- The graft is haematological peripheral blood stem cell. (drugpatentwatch.com)
- But that procedure is often risky and can result in fatal complications, due in part to "graft-versus-host disease," in which transplanted cells react against foreign tissues of the recipient. (scienceblog.com)
- Especially with younger, fitter patients who we can hit harder in the transplant process, we have strong hints here that cord blood may be actively better in terms of reducing both graft-versus-host disease and relapse," Gutman says. (brightsurf.com)
- We think there are important advantages of cord blood, especially with respect to graft-versus-host disease," Gutman says. (brightsurf.com)
- Chronic graft-versus-host-disease (cGVHD) is the leading cause of later non-relapse mortality and morbidity after allo-hematopoietic stem cell transplantation (HCT). (renalandurologynews.com)
- Graft source: Peripheral blood stem cells are associated with higher incidence of cGVHD, compared to bone marrow. (renalandurologynews.com)
- High graft CD34+ cell count. (renalandurologynews.com)
- Because there is diminished risk of graft-versus-host disease after transplantation of cord stem cells using matched related donors, the use of less-than-completely matched HLA cord blood stem cells may incur less risk of graft-versus-host disease than mismatched cells from either a related or unrelated "walking" donor, although this remains to be proven. (aappublications.org)
- Graft Transit Time Has No Effect on Outcome of Unrelated Donor Haematopoietic Cell Transplants Performed in Australia and New Zealand: a Study From the Australasian Bone Marrow Transplant Recipient Registry. (edu.au)
- It is predominately used to treat and prevent relapse after SCT by exploiting the graft-versus-tumor effect (GVT) of donor derived T cells. (renalandurologynews.com)
- It is also used to maximize donor chimerism and treat graft rejection. (renalandurologynews.com)
- A number of complications might happen after an allogeneic transplant. (mskcc.org)
- 5 transplants with only partial matching for HLA antigens are associated with a higher risk of post-transplant complications. (cmaj.ca)
- Lucy Godley, MD, PhD, talks about what stem cell transplants are like for the patient receiving the transplant, potential complications associated with the procedure, and the long-term prognosis after transplant. (uchospitals.edu)
- Our scientists are developing new approaches to lower your risk of treatment-related complications and to reduce the chance that your cancer will come back after transplantation. (nyp.org)
- Allogeneic transplants have been shown to be very effective for many AML patients with aggressive disease, but such transplants are often associated with serious side effects and complications. (bio-medicine.org)
- Loss of hair, reduced blood counts, liver damage and pneumonia are the other complications that could occur with treatment. (medindia.net)
- Many studies of allogeneic marrow transplantation have shown that a higher dose of marrow cells correlates with more robust hematopoietic engraftment and lower mortality from infectious complications. (knowcancer.com)
- Your Child will remain in the hospital until their blood counts recover and they have no other complications related to the transplant. (stanford.edu)
- Our research has a strong focus on reducing the complications of transplantation and also lowering the risk of recurrence. (hackensackumc.org)
- As one of Hadassah University's senior scientists, Prof. Or continues to conduct research on various clinical topics, including the prevention of liver complications following bone marrow transplantation and immunotherapy using donor derived lymphocytes (immune cells) for the eradication of malignant diseases that would otherwise prove fatal. (isracast.com)
- In brief, MSCs, also known as marrow stromal cells [ 11 ] or mesenchymal progenitor cells, are considered the most heavily utilized stem cells in the field of regenerative medicine and tissue engineering [ 12 , 13 ] to overcome the complications and limitations of gene-based therapies. (hindawi.com)
- If we could generate healthy HSCs from patients and transplant them back into their own bone marrow, it would eliminate many complications," said David Traver, an assistant professor of biology who headed the research team. (scienceblog.com)
- According to the team's principal investigator, Dr. Guy Sauvageau, this new synthetic molecule could "multiply by 10 the number of units of cord blood available for transplantation in humans" and would also substantially reduce complications associated with stem cell transplant. (cmaj.ca)
- Impact of total body irradiation on successful neutrophil engraftment in unrelated bone marrow or cord blood transplantation. (nature.com)
- How to Improve Cord Blood Transplantation: By Enhancing Cell Counts or Engraftment? (frontiersin.org)
- This study is designed to test the ability to achieve donor hematopoietic engraftment while maintaining low rates of transplant-related mortality (TRM) in patients with high-risk lysosomal and peroxisomal disorders using a novel conditioning regimen for hematopoietic cell transplantation (HCT). (clinicaltrials.gov)
- Mixed vs full donor engraftment early after hematopoietic cell transplant: Impact on incidence and control of cytomegalovirus infection. (nih.gov)
- 7 The use of blood stem cells is associated with faster recovery of neutrophils and platelets after transplantation (engraftment) than is the case with bone marrow stem cells. (cmaj.ca)
- The study, which involved 130 patients, also found that adding fludarabine to conditioning caused three-fold enhancement of hematopoietic cell engraftment. (medscape.com)
- Co-transplantation of MSCs and hematopoietic stem cells (HSCs) promotes successful engraftment and improves hematopoietic recovery. (springer.com)
- 2004). CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells. (springer.com)
- The terms stem cell transplant , infusion , rescue , engraftment , or support may be used interchangeably and essentially have the same meaning. (lymphomation.org)
- Non-myeloablative ', because the conditioning therapy does not fully ablate (kill off) the bone marrow myeloid cells prior to the engraftment or transplant phase of therapy. (lymphomation.org)
- The concept of utilizing enhanced immunosuppression rather than myeloablative cytotoxic conditioning has allowed the engraftment (acceptance) of allogeneic stem cells from related and unrelated donors with lower early transplant-related mortality (TRM) and morbidity. (lymphomation.org)
- Patients will be clinically assessed and evaluated for engraftment of donor cells and disease response. (clinicaltrials.gov)
- Thus, while most UCB units contain sufficient cells for rapid engraftment of young children, it may be difficult to identify a suitably matched UCB unit with acceptable cell content for older children and adults. (mja.com.au)
- For this reason, iron overload is becoming an important issue also in the engraftment period post-transplantThe aim of this review is to update consolidated knowledge about the role of iron overload/iron toxicity in the HCT setting in non-malignant and in malignant diseases introducing the concept of exposition of free toxic iron forms and related cellular damage in the different stage of transplant. (medworm.com)
- Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. (nature.com)
- Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia. (nature.com)
- Myeloablative unrelated cord blood transplantation in adolescents and young adults with acute leukemia. (stembook.org)
- Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia. (brightsurf.com)
- Acute leukemia needs to be treated when it is diagnosed, with the goal of inducing a remission (absence of leukemia cells in the body). (rxlist.com)
Marrow Transplant Program3
- Dr. Ron Paquette is a member of the Blood and Marrow Transplant Program at Cedars-Sinai. (aamds.org)
- Learn more about research in the Bone Marrow Transplant Program . (mayoclinic.org)
- An affiliate of the National Marrow Donor Program , our bone marrow transplant program is among the most accomplished and respected in the nation. (uhhospitals.org)
- After a reduced-intensity conditioning regimen using volumetric-modulated arc therapy (VMAT)-delivered low-dose total body irradiation (TBI) with highly conformal marrow boosting, patients will be transplanted using either a related or unrelated allograft. (clinicaltrials.gov)
- Conditioning Regimen and the Transplantation of Unrelated Donor Umbilical Cord Blood in Patients With Hematologic Malignancies. (aamds.org)
- Furthermore, introduction of reduced intensity conditioning protocols, better HLA matching, and recognition of the importance of HLA-C have improved CB transplants success by decreasing transplant-related mortality. (frontiersin.org)
- The higher rates of mortality observed after PBSC transplantation compared to bone marrow transplantation should serve as a cautionary note, and underscore the urgent need for a properly designed clinical trial to define the role, if any, of donor peripheral blood stem cell transplantation in children. (news-medical.net)
- We identified 70 publications reporting 45 SNPs in 36 genes significantly associated with disease-related mortality, progression-free survival, transplant-related mortality, and/or overall survival after BMT. (bloodjournal.org)
- Malignancy is frequent in DOCK8 deficiency, predominantly, lymphoma and squamous cell carcinomas, and often leads to early mortality. (frontiersin.org)
- These observations led to the hypothesis that transplantation of PBSC would lead to lower mortality compared to transplantation of marrow. (knowcancer.com)
- A previous single institution study showed that the presence of at least one IL1A T allele in the donor was associated with improved survival after unrelated donor haematopoietic stem cell transplant and lower transplant-related mortality if the donor and recipient each possessed the IL1A T allele. (pubmedcentralcanada.ca)
- An increase in the use of non-related donors, a growing role for umbilical cord blood, a trend towards decreasing treatment-related mortality, and results broadly similar to those from overseas: these are some of the findings in a report from the Australasian Bone Marrow Transplant Recipient Registry. (mja.com.au)
- NK cells also mediate anti-viral protection, in particular against cytomegalovirus (CMV), an infection that causes significant morbidity and mortality following transplant. (jcancer.org)
- Reduced mortality after allogeneic hematopoietic-cell transplantation. (springer.com)
- Reduced mortality of cytomegalovirus pneumonia after hematopoietic cell transplantation due to antiviral therapy and changes in transplantation practices. (springer.com)
- Patients with the following types of non-malignant diseases can participate in this study: Bone marrow failure syndromes (including Severe Aplastic Anemia, Severe Congenital Neutropenia, Amegakaryocytic Thrombocytopenia (Kostmann's Syndrome), Diamond-Blackfan Anemia, Schwachman Diamond Syndrome, Primary Immunodeficiency Syndromes, Acquired Immunodeficiency Syndromes, and Histiocytic Disorders) and Hemoglobinopathies (including Sickle Cell Anemia and Sickle/Beta Thalassemia). (clinicaltrials.gov)
- Bone marrow transplantation was first attempted, albeit unsuccessfully, in 1939, when human bone marrow cells were injected intravenously to treat a patient with aplastic anemia. (cmaj.ca)
- Hematopoietic stem cell transplantation (bone marrow, cord blood, or peripheral blood stem cells) may cure aplastic anemia and prevent myelodysplastic syndrome or leukemia. (medscape.com)
- Memorial Sloan Kettering experts are leaders in diagnosing and treating pediatric blood disorders, including inherited bone marrow failure syndromes , acquired aplastic anemia , and hemoglobinopathies . (mskcc.org)
- NewYork-Presbyterian offers bone marrow and stem cell transplantation for people with hematological malignancies (e.g., leukemia, lymphoma, multiple myeloma, myelodysplastic syndromes (MDS)) for myeloproliferative disorders such as myelofibrosis, for AL-amyloidosis, and for non-malignant blood disorders such as severe aplastic anemia and sickle cell anemia (SCA). (nyp.org)
- Aplastic anemia (the lack of normal blood cell production). (blood.ca)
- Transplantation with blood-forming stem cells can help save the lives of people with blood cancers or diseases like aplastic anemia. (blood.ca)
- Partial T-cell depleted peripheral blood stem cell transplantation from HLA-identical sibling donors for patients with severe aplastic anemia. (stembook.org)
- These global hematopoietic cells from donors or cord blood units are used to transplant patients around the world with a variety of with life-threatening blood disorders such as leukemia, lymphoma, aplastic anemia, as well as certain immune system and metabolic disorders. (wikipedia.org)
- The usual odds ratio is 1 out of 100 CBUs that meet donor-recipient eligibility/match criteria and are transplanted. (frontiersin.org)
- Once a transplant recipient is discharged from hospital and returns to his or her local community, the primary care physician can play an important role in care. (cmaj.ca)
- Allogeneic transplantation represents 40% of all stem cell transplants performed annually in Canada and requires donor and recipient matching for major histocompatibility (HLA) antigens. (cmaj.ca)
- The frequency of c-kit + Sca + Lin − HSCs was higher in recipient BM following co-transplantation of CXCR4-MSCs compared with the EGFP-MSC control and the BMT only groups. (springer.com)
- Chimerism , a term used often in connection with mini-transplants, means the coexistence of donor and recipient cells. (lymphomation.org)
- If the procedure works, the donated cells begin to multiply and produce all the enzymes they produced in the donor - including the one that the transplant recipient was lacking. (news-medical.net)
- The transplant center will enter details of the recipient HLA type and, often after several rounds of HLA testing, the best matched unrelated donor will be selected from the registry. (psychiatryadvisor.com)
- This NIHR Blood Transplant Research Unit project aims to identify and validate donor-specific biomarkers which are predictive of recipient outcome following hematopoietic stem cell transplantation. (ucl.ac.uk)
- This concern is especially serious when the donor is unrelated to the recipient. (knowcancer.com)
- For these transplants to be successful, the donor must be very carefully matched with the recipient. (blood.ca)
- Donor-recipient compatibility is determined by matching for specific human leukocyte antigens (HLAs). (mja.com.au)
- The Vaccine and Infectious Disease Division's Dr. Joshua Hill is the recipient of the Biology of Blood and Marrow Transplantation's 2012 George Santos Award for best clinical science article by a new investigator. (fredhutch.org)
- Donor recipient pairs were categorised into four groups according to the presence or absence of an IL1A T allele in the donor and recipient. (pubmedcentralcanada.ca)
- We did not observe an association with IL-1α genotype in donor and/or recipient and transplant-outcome. (pubmedcentralcanada.ca)
- Donor: Female gender, especially parous female donor and male recipient. (renalandurologynews.com)
- Can the negative effect of being a CMV-seropositive transplant recipient be overcome? (hematology.org)
- Moreover, it is not necessary that the immunological compatibility between donor and recipient is perfect, unlike a bone marrow transplant. (cmaj.ca)
- High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. (springer.com)
- The previous experience among pediatric patients have now expanded to adults, and the number of CB transplants has reached 30,000. (frontiersin.org)
- For information about stem cell transplant for children and teens, visit the Pediatric Stem Cell Transplant page on the University of Chicago Comer Children's Hospital website. (uchospitals.edu)
- Storb R (2004) History of pediatric stem cell transplantation. (springer.com)
- A new study has shown for the first time that transplantation of peripheral blood stem cells (PBSC) from sibling donors may be more harmful than bone marrow in pediatric leukemia patients. (news-medical.net)
- Researchers from the International Bone Marrow Transplant Registry (IBMTR) found that patients undergoing PBSC transplants were more likely to die of transplant-related causes than those who underwent bone marrow transplants.It is estimated that nearly 30% of transplants from sibling donors in pediatric patients now use peripheral blood stem cells. (news-medical.net)
- In adults, peripheral blood collection has become increasingly common in recent years, because it allows donors to avoid the difficulties of bone marrow collection, such as surgery and anesthesia.Since peripheral blood transplantation has been shown to be as safe and effective as bone marrow transplantation in adults, some doctors have begun recommending use of peripheral blood transplants in pediatric patients. (news-medical.net)
- An accompanying editorial by Donna A. Wall, MD, of the Texas Transplant Institute in San Antonio, underscored the need for a prospective study designed to assess PBSC and bone marrow transplantation in pediatric patients. (news-medical.net)
- This is an unsettling finding, given that nearly 30% of transplants from sibling donors in pediatric patients now use peripheral blood grafts," Dr. Wall said. (news-medical.net)
- It very well may be that peripheral blood stem cells do not offer a benefit over bone marrow in pediatric patients. (news-medical.net)
- To better define this outcome in adults and pediatric patients at 1- and 2-years post- allogeneic hematopoietic cell transplantation, we pooled data from the University of Minnesota and the Hôpital Saint-Louis in Paris, France (n=1901). (haematologica.org)
- Comprehensive Prognostication in Critically Ill Pediatric Hematopoietic Cell Transplant Patients: Results from Merging the Center for International Blood and Marrow Transplant Research (CIBMTR) and Virtual Pediatric Systems (VPS) Registries. (stembook.org)
- Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ. (brightsurf.com)
- Our pediatric bone marrow transplant experts at University Hospitals Rainbow Babies & Children's provide highly personalized care to young patients who require the most advanced diagnostic tools and treatment approaches. (uhhospitals.org)
- With an experienced and multidisciplinary team, we have received accreditation from the Foundation for the Accreditation of Cellular Therapy , membership of the National Pediatric Blood and Marrow Transplant Consortium and national designation as a Center of Excellence. (uhhospitals.org)
- Consistently ranked among the best children's hospitals in the nation by U.S. News & World Report, UH Rainbow Babies & Children's Hospital provides compassionate, comprehensive care for patients of all ages with a pediatric cancer or blood disease diagnosis. (uhhospitals.org)
- Research led by St. Jude Children's Research Hospital has identified three genetic alterations to help identify high-risk pediatric patients with acute megakaryoblastic leukemia (AMKL) who may benefit from allogeneic stem cell transplants. (stjude.org)
- Because long-term survival for pediatric AMKL patients without Down syndrome is poor, just 14 to 34 percent, the standard recommendation by many pediatric oncologists has been to treat all patients with allogeneic stem cell transplantation during their first remission," said senior and co-corresponding author Tanja Gruber, M.D., Ph.D. , an associate member of the St. Jude Department of Oncology . (stjude.org)
- In recent years, umbilical cord blood, which contains a rich source of hematopoietic stem and progenitor cells, has been used successfully as an alternative allogeneic donor source to treat a variety of pediatric genetic, hematologic, immunologic, and oncologic disorders. (aappublications.org)
- thus, the majority of transplants have been pediatric cases. (scientificamerican.com)
- Transplantation diagnosis included acute myelogenous leukemia (n = 16), acute lymphoblastic leukemia (n = 6), chronic myelogenous leukemia (n = 5), myelodysplastic syndrome (n = 1), and non-Hodgkin's lymphoma (n = 2). (unboundmedicine.com)
- This is a phase II, single-center study to evaluate the efficacy of a novel cytoreductive regimen followed by CD34+E- selected T cell depleted allogeneic stem cell (or soybean agglutinated and E-rosetted BM) transplant as treatment for patients with acute and chronic leukemias, lymphoma and myelodysplstic syndrome/PNH. (bioportfolio.com)
- Dr Colin Phipps Diong, Parkway Cancer Centre's new consultant specialising in lymphoma and blood cancers, and haematopoietic stem cell transplantation, explains haematopoietic stem cell transplantation. (thedailystar.net)
- Various types of blood cancers such as leukemia, lymphoma or myeloma. (blood.ca)
- Northside Hospital Cancer Institute (NHCI) Immunotherapy Program is part of our nationally recognized treatment center for leukemia, lymphoma, myeloma, and blood and marrow transplant. (northside.com)
- When no compatible donor can be found, stem cells from umbilical cords are transplanted to treat blood diseases such as leukemia, myeloma and lymphoma. (cmaj.ca)
- We analyzed 42 lymphoma and chronic lymphoblastic leukemia (CLL) patients who underwent haplo-cord allogeneic stem cell transplantation. (unboundmedicine.com)
- Patients underwent transplant for Hodgkin lymphoma (n = 9, 21%), CLL (n = 5, 12%) and non-Hodgkin lymphomas (n = 28, 67%), including 13 T cell lymphomas. (unboundmedicine.com)
- day + 180 post-transplant. (aamds.org)
- You may have the opportunity to participate in a clinical trial evaluating new approaches to enhancing post-transplant care. (hackensackumc.org)
- In the pre-transplant and post-transplant setting, patients will be evaluated by an integrated team of Rheumatology and BMT physicians. (clinicaltrials.gov)
- Less commonly, it is used to enhance immune reconstitution, to treat severe infectious illness and to treat post-transplant lymphoproliferative disorder (PTLD). (renalandurologynews.com)
- Patients require regular blood transfusion therefore they develop iron overload causing organ damage and hematopoietic cell transplantation (HCT) is a consolidated reliably curative option.In this category of patients an important issue for transplant outcome is the iron burden before transplant and in the long-life post-transplant. (medworm.com)
- A study by MacMillan et al reported that alternative donor hematopoietic cell transplantation had a high success rate in patients with Fanconi anemia who did not have a history of opportunistic infections or transfusions and who underwent conditioning with single fraction total body irradiation 300 cGy, cyclophosphamide, fludarabine, and antithymocyte globulin. (medscape.com)
- Our approach does not require total-body irradiation to destroy the body's damaged stem cells prior to the transplant . (mskcc.org)
- This study also monitors the activity and toxicity of total body irradiation and cyclosphosphamide followed by stem cell transplantation from matched unrelated donors. (bioportfolio.com)
- Thus the study population included 426 patients older than 18 years with chronic myeloid leukaemia (CML), transplanted in first chronic phase and receiving a total body irradiation and cyclophosphamide preparative regimen. (pubmedcentralcanada.ca)
- Preventing Measles in Immunosuppressed Cancer and Hematopoietic Cell Transplantation Patients: A Position Statement by the American Society for Transplantation and Cellular Therapy. (nih.gov)
- For some people, there is a chance that their cancer can come back after a stem cell transplant. (mskcc.org)
- In rare instances, people who have had a transplant may get a secondary cancer such as leukemia or a myelodysplastic syndrome . (mskcc.org)
- cancer cells. (bioportfolio.com)
- Relapse remains the biggest challenge for cancer patients who have undergone stem cell transplantation. (uchospitals.edu)
- Studying stem cells may help explain how serious conditions such as birth defects and cancer come about. (medlineplus.gov)
- Our transplantation experts are closely integrated with our world-class teams of blood cancer experts and transplantation immunologists. (nyp.org)
- Our Bone Marrow and Hematopoietic Stem Cell Transplantation Program is a Center of Excellence in stem cell transplantation, as designated by the National Cancer Institute and accredited by FACT (Foundation for the Accreditation of Cellular Therapy). (nyp.org)
- The basis of her work stems from the theory that cancer patients' immune systems should recognize tumor cells as foreign and destroy them. (hopkinsmedicine.org)
- This doesn't happen, theorizes Dr. Symons, because the immune system attacks only those cells it perceives as dangerous-not cancer cells, which it sees simply as foreign. (hopkinsmedicine.org)
- In a separate yet equally compelling research endeavor, Dr. Symons is working to increase the availability of donors for children whose cancer requires bone marrow transplants (BMTs) as a potentially lifesaving treatment. (hopkinsmedicine.org)
- Blood Cancer J . 2017 Sep 8. (medscape.com)
- In these anxious times, Jason Chiasson is counting on an anonymous donor to help him beat blood cancer. (blood.ca)
- High-Dose Cancer Therapy : Pharmacology, Hematopoietins, Stem Cells. (worldcat.org)
- I thought you might be interested in this item at http://www.worldcat.org/oclc/913799496 Title: High-Dose Cancer Therapy : Pharmacology, Hematopoietins, Stem Cells. (worldcat.org)
- Hematopoietic stem cell transplant and cancer immunotherapy. (hopkinsmedicine.org)
- For more than 25 years, physicians in the Adult Blood and Marrow Stem Cell Transplantation Program at John Theurer Cancer Center, part of Hackensack University Medical Center in New Jersey, have provided this lifesaving therapy. (hackensackumc.org)
- For example, we are the first team in the world to combine checkpoint inhibitors (drugs that work by inhibiting the proteins cancer cells use to evade detection by the immune system) after transplantation, at a time where the newly reset immune system has the best opportunity to eliminate residual cancer cells. (hackensackumc.org)
- JMML is an aggressive and rare type of blood cancer, which develops in the bone marrow and is characterized by an overproduction of white blood cells. (ucsf.edu)
- In our cancer patients with weakened immune systems who receive a stem cell transplant, it is particularly problematic and can cause a fatal central nervous system infection in up to 5 percent of certain patient groups. (fredhutch.org)
- University Hospitals Seidman Cancer Center is at the forefront of cell therapy, with multiple clinical trials available to patients that will ultimately lead to new treatments. (uhhospitals.org)
- The Cellular Therapy Laboratory manufactures large numbers of cells for physicians who use them in clinical trials targeting cancer, as well as conditions such as multiple sclerosis and cystic fibrosis. (uhhospitals.org)
- UH Seidman Cancer Center has long been a leader in stem cell therapy. (uhhospitals.org)
- Researchers here have built on more than 30 years of groundbreaking work using stem cells to treat cancer and other diseases. (uhhospitals.org)
- Dr. Lazarus and his colleagues have done pioneering work in bone marrow and stem cell transplantation and have developed new treatment approaches to help patients battle their cancer more successfully than ever before. (uhhospitals.org)
- He has developed clinical trials on using MSCs as a therapeutic infusion for blood stem cell transplantation and for the correction of genetic disorders, as well as inhibitors of DNA repair to improve the efficacy of anti-cancer agents. (uhhospitals.org)
- These studies may predict stem cell diseases of aging and cancer. (uhhospitals.org)
- Joseph Baar , MD, PhD, is piloting a new approach for select women with metastatic breast cancer - a vaccine targeting tumor blood supply. (uhhospitals.org)
- Attempts to develop a breast cancer vaccine have repeatedly met with failure because the cancer cells evade immune cells, either by changing or not expressing the molecular targets that the immune cells seek. (uhhospitals.org)
- Stem cells can mature into blood cells (white blood cells, red blood cells, and platelets), which are often damaged by cancer. (doctors-hospital.net)
- Hodgkin's disease rarely affects the bone marrow, so cells from the patient are usually cancer-free. (doctors-hospital.net)
- When a cancer patient needs a bone marrow transplant, there are four common donor sources: A matched related donor (sibling), a matched unrelated donor (from a donor database), a half-matched donor, or umbilical cord blood. (brightsurf.com)
- Our program at CU Cancer Center is somewhat unique in its emphasis on cord blood as a donor source for stem cell transplants and this study is an affirmation of why we do what we do here," says Jonathan Gutman, MD, CU Cancer Center investigator and director of the allogeneic stem cell transplantation program at UCHealth University of Colorado Hospital. (brightsurf.com)
- Also, research at CU Cancer Center and elsewhere is developing techniques to expand small samples of banked cord blood to the volume needed for transplant. (brightsurf.com)
- AMKL is a cancer of megakaryocytes, which are blood cells that produce the platelets that help blood clot. (stjude.org)
- Such genes can lead to abnormal proteins that drive the unchecked cell division and other hallmarks of cancer. (stjude.org)
- Northside Hospital has been doing cancer immunotherapy for decades in the form of allogeneic stem cell transplantation, in which a donor's bone marrow or blood is transplanted into a patient to cure aggressive blood cancers. (northside.com)
- Such transplants represented the first definitive proof of the human immune system's capacity to cure cancer. (northside.com)
- However, the immune system has trouble eliminating cancer cells because of the way cancer cells have evolved, with the ability to hide and trick the immune system in order to survive. (northside.com)
- These are biologic agents, or proteins, given via IV, that attach to both immune cells and cancer cells and bring them together in proximity, helping the immune system's ability to fight cancer. (northside.com)
- With immunotherapy, instead of directly targeting cancer cells themselves, we indirectly stimulate or boost one's immune system to fight the cancer. (northside.com)
- Northside is among select centers in the country to offer chimeric antigen receptor (CAR) T-cell therapy, one of the most promising cell-based cancer immunotherapies available. (northside.com)
- This enables the T-cells to better recognize and kill cancer cells. (northside.com)
- Infusing CAR T-cell product back to the patient to target and kill malignant cancer cells. (northside.com)
- Our Immunotherapy Program physicians are experts in administering CAR T-cell therapy and other immunotherapy cancer treatments, and Northside is one of only a handful of facilities in the Southeast (two in Georgia) that has the capacity and facilities to manage the toxicity of immunotherapy agents. (northside.com)
- The main concern of DKMS is the continued expansion of the registry to give as many blood cancer patients as possible a new chance at life. (parentsguidecordblood.org)
- Activated Leukocyte Cell Adhesion Molecule (CD166): An "Inert" Cancer Stem Cell Marker for Non-Small Cell Lung Cancer? (wiley.com)
- This innovative project will help solve the challenges of treatment for people in Ukraine with onco-haematological disease (blood cancer). (parentsguidecordblood.org)
- He also has an appointment with the Division of Blood and Marrow Transplantation at the Markey Cancer Center. (scientificamerican.com)
- Crystal Day, diagnosed with acute myeloid leukemia at 26, received a cord blood transplant two years ago for recurrent disease and has been cancer-free ever since. (fredhutch.org)
- She went to urgent care that day, and a blood test soon revealed the cancer overtaking her blood cells. (fredhutch.org)
- This time, her oncologist at Seattle Cancer Care Alliance , Fred Hutch's clinical care partner, told Day her only option for a cure was a stem cell transplant. (fredhutch.org)
- But even with this lifesaving procedure, some patients can relapse - especially if doctors aren't able to put the cancer into complete remission prior to transplant. (fredhutch.org)
- Lacking a matched donor in her family or the national bone marrow registry, Day received a transplant two years ago using cells from umbilical cord blood, and it worked - she's been cancer-free ever since. (fredhutch.org)
- Now, a new study from researchers at Fred Hutchinson Cancer Research Center published Wednesday in The New England Journal of Medicine describes results from Day and others like her - patients who have received stem cell transplants from cord blood or from unrelated adult donors at Fred Hutch. (fredhutch.org)
- These patients, who make up about a third of those facing a stem cell transplant, have what is known as "minimal residual disease" - the chemo required before transplant isn't completely successful at putting their cancer into remission, and small amounts of the disease remain. (fredhutch.org)
- Only about a third of patients with detectable cancer in their blood at the time of transplant will still be alive three years later , a 2013 Hutch study found, as compared to nearly three-quarters of those without such residual disease. (fredhutch.org)
- In fact, the patients in their study with minimal residual disease - about one-third of the 582 patients in the study - who were transplanted with cord blood cells were no more likely to relapse or die than patients without the detectable cancer cells who'd also received a cord blood transplant, the researchers found. (fredhutch.org)
- Those who'd received a traditional transplant from an unrelated donor were on average more than three times as likely to relapse if they had minimal residual disease than those without detectable cancer cells in their blood, and they were more than twice as likely to die. (fredhutch.org)
- A team of researchers from the Institute for Research in Immunology and Cancer (IRIC) at the Université de Montréal have discovered a new molecule, UM171, that can be used to increase the number of stem cells found in umbilical cord blood. (cmaj.ca)
- An aggressive blood cancer usually diagnosed in patients younger than 5, JMML accounts for 1 to 2 percent of all childhood leukemia cases. (ucsf.edu)
- The most striking aspect of our findings was that the treatment helped the mice not by making the cancer cells go away, but by forcing them to act like normal cells, despite their mutation," said first author Natalya Lyubynska, MD, an internal medicine resident at the University of Michigan. (ucsf.edu)
- While ideally we prefer using fully matched transplants from a sibling for the treatment of hematologic cancers, only the minority of patients have such a sibling," said study lead investigator Leslie Kean, M.D., Director of the Stem Cell Transplantation Program, Dana Farber/Boston Children's Cancer and Blood Disorders Center. (pipelinereview.com)
- Stem cell transplant infusions include donor T-cells, a type of white blood cell that recognizes and destroys foreign invaders in the recipient's body including cancer cells. (pipelinereview.com)
- Wendy Stock, MD, is an expert in leukemia and stem cell transplantation. (uchospitals.edu)
- Kanate AS, Pasquini MC, Hari PN, Hamadani M (2014) Allogeneic hematopoietic cell transplant for acute myeloid leukemia: Current state in 2013 and future directions. (springer.com)
- BOSTON--A stem cell transplant (SCT) from a compatible donor early in the course of disease is the best approach for the majority of young and middle-aged adult patients with acute myeloid leukemia (AML), according to a new analysis of two dozen clinical studies. (bio-medicine.org)
- Animation and slides providing graphic explanation of Bone Marrow Transplantation (BMT)/Stem Cell Transplantation that is done for leukemia and other blood-related disorders. (medindia.net)
- In addition, PBSC grafts have a higher T cell content, predicting a possibly more powerful anti-leukemia effect. (knowcancer.com)
- PBSC transplantation with bone marrow transplantation from HLA-compatible unrelated donors for patients with leukemia, myelodysplastic or myeloproliferative syndromes. (knowcancer.com)
- Others are using those precious cord blood samples for fundamental research that may one day lead to better therapies for acute myeloid leukemia or other diseases. (blood.ca)
- Your transplant team features doctors with decades of experience in stem cell and bone marrow transplantation, including specialists who focus on specific diseases such as leukemia and multiple myeloma. (hackensackumc.org)
- Outcome of patients with abnl(17p) acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation. (stembook.org)
- His team developed the use of stem cells from umbilical cords to treat leukemia and also discovered a new type of stem cell, mesenchymal (MSCs). (uhhospitals.org)
- When leukemia comes back, as it has in this case, there is zero chance for a cure without a transplant," he said. (cbslocal.com)
- The chemo is what wipes out the leukemia cells in the bone marrow, and then the stem cells restore the bone marrow - which is essential for life. (cbslocal.com)
- Giving treosulfan and fludarabine together with a donor bone marrow transplant or a peripheral stem cell transplant may be an effective treatment for acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndrome. (drugpatentwatch.com)
- PURPOSE: This phase II trial is studying giving treosulfan together with fludarabine to see how well it works in treating patients who are undergoing a donor stem cell transplant for acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndrome. (drugpatentwatch.com)
- CAR T-cell infusion occurs on the Northside Hospital Inpatient Blood and Marrow Transplant, Leukemia and Immunotherapy Unit. (northside.com)
- Thus, cord blood is utilized for the treatment of many diseases--such as leukemia, sickle cell anemia and Hodgkin's disease--that are typically remedied by bone marrow transplants ( see table ). (scientificamerican.com)
- There's no way to actually tell how deep the leukemia cells are in your marrow. (fredhutch.org)
- For those like Day, patients with leukemia and other blood cancers, blood stem cell transplants often offer the best hope of a cure. (fredhutch.org)
- The study found that such transplants may have advantages beyond offering an alternative stem cell source for patients without a traditional donor match - they seem to perform better against leukemia and the related bone marrow disorder, myelodysplastic syndrome, in patients at high risk of relapse after transplant. (fredhutch.org)
- The genetic changes or specific characteristics of the leukemia cells as determined in the laboratory can also determine the type of treatment that may be most appropriate. (rxlist.com)
- Some people with chronic leukemia may be candidates for stem cell transplantation, which does offer a chance for cure. (rxlist.com)
- Human clinical trials are set to start in December to test an innovative approach to treating life-threatening blood diseases, such as leukemia. (cmaj.ca)
- This microscopic image shows blood cells of mice treated in a study that focused on a rare form of leukemia called juvenile myelomonocytic leukemia or JMML. (ucsf.edu)
- 8 , 9 Umbilical cord blood harvested at the time of delivery is also used for this purpose. (cmaj.ca)
- Bone marrow, peripheral blood or umbilical cord blood as favorable source? (springer.com)
- alternative donors transplant including umbilical cord blood, transplantation of malignant and non-malignant disease. (aamds.org)
- Scientists at the Stowers Institute for Medical Research, and the University of Kansas Medical Center, have identified a way to expand blood-forming adult hematopoietic stem cells (HSCs) from human umbilical cord blood (hUCB), without differentiating the cells into mature blood cells. (genengnews.com)
- Using a short hairpin RNA (shRNA) to block YTHDF2 in human umbilical cord HSPCs similarly led to significantly increased levels of ex vivo HSC self-renewal and expansion, resulting in eight times as many functional HSCs when compared with HSC self-renewal in control cells. (genengnews.com)
- Umbilical Cord Blood Transplants -using stem cells from the umbilical cord of a newborn. (nyp.org)
- In many cases, we use umbilical cord blood donors for these partially matched transplants. (nyp.org)
- Another type of HSC source is cord blood cells that are used in umbilical cord blood transplants. (thedailystar.net)
- For patients who are unable to find a suitably-matched sibling or unrelated donor, umbilical cord blood that is available as an "off the shelf" source of frozen HSC can be used. (thedailystar.net)
- With a stem cell transplant, the stem cells ** obtained from bone marrow, peripheral blood, or umbilical cord blood are given back to the patient following high dose treatment, which can damage or ablate (kill off) these vital cells. (lymphomation.org)
- Blood in the umbilical cord also contains hematopoietic stem cells. (lymphomation.org)
- Umbilical cord blood - rich lifesaving stem cells - are collected from the umbilical cord and placenta after the safe delivery of a baby. (blood.ca)
- Throughout pregnancy, the umbilical cord nourishes the unborn baby with blood rich in nutrients and oxygen. (blood.ca)
- After birth, placental and umbilical cord blood can be collected, stored and used as a source of stem cells for transplantation. (lls.org)
- The department uses stem cells from various sources including bone marrow, peripheral blood, umbilical cord blood and the placenta. (isracast.com)
- Moreover, Prof. Or serves as the Medical Director of the Volunteer Bone Marrow Bank and also as the Medical Director of the Israeli National Public Umbilical Cord Blood Bank. (isracast.com)
- In December 2008 Prof. Or received the Menachem Begin Prize for his extensive medical and research work and for the establishment of two essential and life saving national projects: The unrelated volunteer bone marrow donor registry and the national public umbilical cord blood bank. (isracast.com)
- O nce considered a biological waste product, umbilical cord blood (UCB) has emerged as a viable source of haematopoietic stem cells for transplantation. (mja.com.au)
- Umbilical cord blood contains one-tenth of the number of stem cells found in bone marrow. (mja.com.au)
- Although the application of various types of stem cells, such as bone marrow-derived mesenchymal stem cells (BM-MSCs), adipose tissue-derived mesenchymal stem cells (AT-MSCs), and umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), has promising potential to improve the health of different species, it is crucial that the benefits and drawbacks are completely evaluated before use. (hindawi.com)
- Infections of the Central Nervous System Following Unrelated Donor Umbilical Cord Blood Transplantation or HLA-Matched Sibling Transplantation. (stembook.org)
- Because these umbilical cord stem cells are more "basic" than adult blood cells, they require a lower degree of match than blood cells from an adult donor. (brightsurf.com)
- CGVHD is less common in adults after double umbilical cord blood transplantation (26% at 2 years), compared to sibling or URD transplant. (renalandurologynews.com)
- When a baby is born, his or her umbilical cord is filled with a small amount of blood. (womenfitness.net)
- Put simply, the blood from your child's umbilical cord could save a human life. (womenfitness.net)
- Unlike embryonic stem cells, umbilical cord blood is a non-controversial source of stem cells. (womenfitness.net)
- Cord blood stem cells not only occur in higher concentration than bone marrow stem cells, but they also have a higher capacity to replicate since they are harvested from the umbilical cord blood when they are very young, and, due to preservation, they do not age, hence their vitality is preserved. (womenfitness.net)
- What are the Umbilical Cord Blood Stem Cells Used For? (womenfitness.net)
- To get these stem cells, your doctor will draw blood from the umbilical cord at the time of your baby's birth . (womenfitness.net)
- He is chief executive of the European umbilical cord blood bank network FamiCord Group and co-founder of a public cord blood bank in Poland created in early 2011. (parentsguidecordblood.org)
- To begin, we want to donate 100 samples of umbilical cord blood hematopoietic stem cells. (parentsguidecordblood.org)
- Over the past decade, unrelated-donor, banked umbilical cord blood has been shown to contain sufficient numbers of stem cells for successful transplantation between unrelated, partially HLA-mismatched individuals. (aappublications.org)
- Recently, it was shown that umbilical cord blood contains a sufficient number of hematopoietic stem cells to be used for transplantation. (aappublications.org)
- For which diseases or conditions is umbilical cord blood stem-cell therapy most effective? (scientificamerican.com)
- Blood that remains in the human umbilical cord and placenta after birth supplies doctors with a rich source of hematopoietic progenitor cells (stem cells), the precursors of all other blood cells. (scientificamerican.com)
- The future holds great promise for the use of umbilical cord blood stem cells. (scientificamerican.com)
- However, the number of stem cells obtained from a unit of blood from an umbilical cord is usually too low to treat an adult. (cmaj.ca)
- The blood of a newborn's umbilical cord is a rich source of hematopoietic stem cells for transplantation. (cmaj.ca)
- Barriga F, Ramírez P, Wietstruck A, Rojas N. Hematopoietic stem cell transplantation: clinical use and perspectives. (nature.com)
- This study is a clinical trial for patients diagnosed with a non-malignant disease who will receive a peripheral blood stem cell transplant. (clinicaltrials.gov)
- Early Clinical Predictors of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Myeloablative Stem Cell Transplantation. (harvard.edu)
- Absolute lymphocyte count recovery after allogeneic hematopoietic stem cell transplantation predicts clinical outcome. (harvard.edu)
- White blood cell recovery after allogeneic hematopoietic cell transplantation predicts clinical outcome. (harvard.edu)
- If the technique can be translated into a clinical setting, it could make cord blood HSC transplants more readily available to eligible patients with blood cancers, and immune and genetic disorders, for whom a suitable bone marrow donor can't be found. (genengnews.com)
- You may have the opportunity to participate in a clinical trial studying new, safer methods of preparing for, receiving, and recovering from a bone marrow transplant. (nyp.org)
- In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies Companies in our database. (bioportfolio.com)
- They found that over the long term, patients with poor- and intermediate-risk AML who received allogeneic stem cell transplants in first clinical remission were more likely to be alive than those who received alternative therapies, and were less likely to suffer disease relapse. (bio-medicine.org)
- This prospective, randomized, multicenter clinical trial of unrelated donor transplantation will test the hypothesis that transplantation of PBSC leads to similar patient survival compared to transplantation of marrow. (knowcancer.com)
- The NMDP's cord blood programis a clinical trial developed in1998 under an Investigational NewDrug application (IND) with the USFood and Drug Administration (FDA).The NMDP continues to work withexisting cord blood banks to establishnew contacts and list more cord bloodunits in the NMDP Registry. (cancernetwork.com)
- By providing cord blood products to Canadian researchers, the Cord Blood for Research Program has the potential to generate improvements in cord blood banking and (or) transplant processes that would increase the clinical utility of cord blood. (blood.ca)
- This review focuses on the benefits and current limitations of UCB, clinical results in paediatric and adult patients undergoing unrelated UCB transplant, strategies to improve results, and future direction and use of cord blood. (mja.com.au)
- Pioneering innovations in stem cell research have been accomplished by the collaboration of clinical and veterinary scientists. (hindawi.com)
- The editors of the journal, a publication of the American Society for Blood and Marrow Transplantation, selected Hill, a senior fellow in VIDD's Clinical Research Program, for his article 'Cord-Blood Hematopoietic Stem-Cell Transplantation Confers an Increased Risk for Human Herpesvirus-6-Associated Acute Limbic Encephalitis: A Cohort Analysis. (fredhutch.org)
- Transfusion of ABO non-identical platelets does not influence the clinical outcome of patients undergoing autologous haematopoietic stem cell transplantation. (stembook.org)
- The clinical benefit of instituting a prospective clinical community-acquired respiratory virus surveillance program in allogeneic hematopoietic stem cell transplantation. (stembook.org)
- Together, they produced publications and patents related to MSCs and then oversaw four first clinical trials using these cells. (uhhospitals.org)
- Our findings are an important step toward this goal because they provide a better understanding of how HSCs, the cell type responsible for the clinical benefits of bone marrow transplants, are first specified during development," he said. (scienceblog.com)
- Our young patients also benefit from the latest clinical research and advanced medicine for bone marrow transplantation. (uhhospitals.org)
- Palmer JM, Rajasekaran K, Thakar MS, Malarkannan S. Clinical Relevance of Natural Killer Cells Following Hematopoietic Stem Cell Transplantation. (jcancer.org)
- 19 - 23 With advances in the clinical practice of cord blood transplantation, most patients unable to find a fully matched adult donor can identify a partially matched cord blood donor. (aappublications.org)
- In the transplantation discipline, collection of data from clinical trials will continue to improve knowledge, thereby helping to increase survival rates. (scientificamerican.com)
- However, only a few controlled trials have been reported, and decisions on patient selection for hematopoietic stem cell transplantation and transplant management remain principally dependent on data from retrospective analyses and on the clinical experience of the transplant centers. (haematologica.org)
Unrelated-donor hematopoietic stem cell trans1
- A study by Wang et al suggested that in patients with Fanconi anemia, the 1-year overall survival rate following unrelated-donor hematopoietic stem cell transplantation is poor in those with clonal or complete copy gains in the q arm of chromosome 3 or with abnormalities in three or more chromosomes. (medscape.com)
- Stem cell transplant (also known as bone marrow transplant or BMT) is an established treatment for many cancers and blood diseases once considered incurable. (uchospitals.edu)
- Sequential infusion of donor-derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation. (harvard.edu)
- Bone marrow and stem cell transplantation have evolved into the standard of care for many people with hematologic cancers and other blood disorders, and their use is expected to grow by 20 percent over the next decade. (nyp.org)
- Advances in hematopoietic stem cell transplantation have made this approach an option for more people with hematologic cancers and benign blood disorders, including older patients and those with multiple medical issues. (hackensackumc.org)
- Haematopoietic stem cell transplantation (see Box 2 for glossary of terms) is an accepted therapy for many cancers or inherited disorders that originate or manifest as primary abnormalities of the blood or bone marrow. (mja.com.au)
- Thanks to ongoing medical research, bone marrow transplants have become an effective therapeutic approach to treat certain cancers and blood disorders. (uhhospitals.org)
- NK cells protect against a variety of cancers and infections 1 . (jcancer.org)
Biology of Blood and Marrow Transplantation3
- Biology of Blood and Marrow Transplantation in press, 2015. (upenn.edu)
- Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, vol. 21, no. 7, 2015, pp. 1299-307. (unboundmedicine.com)
- Biology of Blood and Marrow Transplantation , 23(1), 147-152. (edu.au)
- Management of Infectious Diseases in Stem Cell Transplantation and Hematologic Malignancy. (nih.gov)
- HEMATOPOIETIC STEM CELL TRANSPLANTATION has been used for many years to treat various malignant and nonmalignant hematologic conditions. (cmaj.ca)
- Myeloablative haplo transplantation using this regimen is a valid option for patients with advanced hematologic malignancies who lack timely access to a conventional donor. (unboundmedicine.com)
- One of Dr. Symons' research pursuits focuses on using a novel immunotherapy approach to treating both solid tumors and hematologic (blood-borne) malignancies. (hopkinsmedicine.org)
- Tolar J, Sodani P, Symons, H. Alternative donor transplant of benign primary hematologic disorders. (hopkinsmedicine.org)
- This phase I trial studies the side effects of zoledronic acid given after genetically modified donor stem cell transplant in treating younger patients with hematologic malignancies or high risk tumors that have returned after a period of improvement (relapsed) or do not respond to treatment (refractory). (cancer.gov)
- Long-term Survival after Transplantation of Unrelated Donor Peripheral Blood or Bone Marrow Hematopoietic Cells for Hematologic Malignancy. (stembook.org)
- I. To assess whether 2 weeks of statin treatment of normal PBSC donors is feasible, tolerable and safe. (clinicaltrials.gov)
- The Effect of Aging and Pre-Donation Comorbidities on the Related PBSC Donor Experience: A Report from the Related Donor Safety Study (RDSafe). (stembook.org)
- The objective of the trial is to test the null hypothesis that there is no difference in overall survival after PBSC versus marrow transplants from HLA compatible unrelated donors. (knowcancer.com)
- The NMDP performs thistask by maintaining a registry of morethan 4.9 million volunteer donors ofmarrow and peripheral blood stemcells (PBSC) and 12 cord blood bankscontaining more than 25,000 units ofumbilical cord blood. (cancernetwork.com)
- single-donor platelets are preferred to reduce the frequency of antibody formation. (medscape.com)
- Recovery of donor-derived peripheral blood leukocytes and platelets was accelerated when CXCR4-MSCs were co-transplanted with BM cells. (springer.com)
- and platelets , which help the blood to clot. (lymphomation.org)
- Bone marrow failure is usually diagnosed by the low number of circulating blood cells including red blood cells, white blood cells, and platelets. (rarediseases.org)
- Our blood contains red cells, platelets and white cells suspended in plasma, the liquid part of our blood. (lls.org)
- Platelets are small cells (one-tenth the size of red cells) that help stop bleeding at the site of an injury. (lls.org)
- Platelets stick to the vessel's torn surface, clump together and plug up the bleeding site with the help of blood-clotting proteins such as fibrin and electrolytes such as calcium. (lls.org)
- Platelets also release growth factors that stimulate wound repair and new blood vessel formation. (lls.org)
- Unlike red cells and platelets, phagocytes can leave the blood and enter the tissues, where they can attack invading organisms and help combat infection. (lls.org)
- Blood passes through the marrow and picks up fully developed and functional red cells, white cells and platelets for circulation in the body. (lls.org)
- Stem cells produce red blood cells, white blood cells, and platelets. (lahey.org)
- If the transplant is successful, new bone marrow cells will produce healthy red blood cells, white blood cells, and platelets. (lahey.org)
- Thus, CB has many features resembling fetal or even embryonic stem cells. (frontiersin.org)
- There are two main types of stem cells: embryonic stem cells and adult stem cells. (medlineplus.gov)
- Blood stem cells are not embryonic stem cells. (blood.ca)
- Researchers at Lund University in Sweden have developed a faster method to generate functional brain cells, called astrocytes, from embryonic stem cells. (brightsurf.com)
- A graphic representation of theNMDP network is shown in Figure 1.The national coordinating center of theNMDP, located in Minneapolis, Minnesota,houses the computerized NMDPregistry of unrelated stem cell donors,including data on the inventories ofNMDP-affiliated cord blood banks.Searches of the NMDP Registry forHLA-matched donors or umbilicalcord blood units are accomplishedthrough secure electronic communicationsbetween the NMDP and itsnetwork of donor centers, apheresiscenters, collection centers, transplantcenters, and HLA laboratories. (cancernetwork.com)
- In total there are four transplantation centers in the state, however, during all the time of independence, no transplants from an unrelated donor have been performed. (parentsguidecordblood.org)
- Today, most centers use quantitative polymerase chain reaction (PCR) on blood samples to monitor patients and guide the use of antiviral therapy. (hematology.org)
- The survival rate after transplantation from alternative donors is improving, depending on the completeness of the HLA-matching. (medscape.com)
- Use of matched unrelated donors compared with matched related donors is associated with lower relapse and superior progression-free survival after reduced-intensity conditioning hematopoietic stem cell transplantation. (harvard.edu)
- HLA-C mismatch is associated with inferior survival after unrelated donor non-myeloablative hematopoietic stem cell transplantation. (harvard.edu)
- Donor chimerism early after reduced-intensity conditioning hematopoietic stem cell transplantation predicts relapse and survival. (harvard.edu)
- For all AML patients other than the minority with "good-risk" disease, SCT from a compatible donor significantly improves survival, making it the preferred approach, the authors state. (bio-medicine.org)
- Speed is important, particularly in high-risk malignancies and congenital neurodegenerative disorders, when time to transplant can affect survival and neurological outcome. (mja.com.au)
- Our 100-day patient survival rate for bone marrow transplant patients exceeds 96 percent. (uhhospitals.org)
- The 1-year survival may be as high as 75% to 90% after sibling HLA-matched cord blood donor stem cell transplantation 21 , 24 , 29 and 40% to 80% after unrelated cord blood stem cell transplantation. (aappublications.org)
- Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis. (edu.au)
- The hematopoietic niche of the bone marrow supports the survival and self-renewal of HSCs and HPCs, yet prevents the ill-timed release of these cells into the circulation. (nih.gov)
- Spring L, Li S, Soiffer RJ, Antin JH, Alyea III, Glotzbecker B. Risk factors for readmission after allogeneic hematopoietic stem cell transplantation and impact on overall survival. (springer.com)
- Recognizing the distinct needs of this population, we've assembled a multidisciplinary team of stem cell transplant and geriatric oncology experts to design a care program tailored specifically for patients over 60. (uchospitals.edu)
- Many of our nurses have achieved certification in oncology and bone marrow transplantation. (hackensackumc.org)
- Prof. Reuven Or, the director of the Center for Stem Cell Ttransplantation, Research, and Development, completed his fellowship in hematology/oncology at the Hadassah University Medical Center where he specialized in bone marrow transplantation. (isracast.com)
- Recent research led by Professor G.V. Shivashankar of the Mechanobiology Institute at the National University of Singapore and the FIRC Institute of Molecular Oncology in Italy, has revealed that mature cells can be reprogrammed into re-deployable stem cells without direct genetic modification -- by confining them to a defined geometric space for an extended period of time. (brightsurf.com)
- Our care teams perform more than 200 stem cell transplants a year and we perform more allogeneic transplants (transplants using bone marrow or stem cells from donors) for older adults than any other center in the tri-state area. (nyp.org)
- Approximately half of all allogeneic transplants in the USA are performed from unrelated donors. (psychiatryadvisor.com)
- Allogeneic transplants use blood-producing stem cells from a genetically matched donor. (stjude.org)
Cord blood transplants4
- Hill found that patients who receive unrelated cord-blood transplants are at particularly high risk for reactivation of human herpesvirus-6. (fredhutch.org)
- Death from HHV-6-PALE occurred in 50 percent of affected patients who underwent cord blood transplants. (fredhutch.org)
- Including Day, 140 of those patients received cord blood transplants. (fredhutch.org)
- Cord blood transplants have been used worldwide at an increasing rate since the late 1990s, but only 5% of adults can be treated efficiently this way, according to Roy. (cmaj.ca)
- The actual transplantation of the cells is a simple process involving intravenous infusion of a liquid stem cell product through a large-bore central venous catheter over 1 to 2 hours. (cmaj.ca)
- The treatment that immediately precedes infusion of HSC is called conditioning therapy and is given to help kill tumour cells, "wipe out the memory" of the recipient's immune system, and create "space" within the bone marrow for the incoming stem cells to grow. (thedailystar.net)
- Patients will be treated for two weeks to prepare them for the infusion of blood stem cells that are obtained from their HLA-matched donor. (clinicaltrials.gov)
- Patients will be admitted to the in-patient service for the first 5 days of the transplant preparative regimen while receiving the ATG infusion. (clinicaltrials.gov)
- Patients will start immunosuppressive treatment with cyclosporine and mycophenolate mofetil prior to the infusion of mobilized peripheral blood stem cells. (clinicaltrials.gov)
- The process is similar to receiving a blood product infusion. (northside.com)
- Donor lymphocyte infusion. (renalandurologynews.com)
- the infusion of stem cells is similar to receiving a blood transfusion. (scientificamerican.com)
- Donor leukocyte infusion (DLI) has several indications after both myeloablative and non-myeloablative allogeneic stem cell transplantation (SCT). (renalandurologynews.com)
Donor's stem cells2
- Which is more important for the selection of cord blood units for haematopoietic cell transplantation: the number of CD34-positive cells or total nucleated cells? (nature.com)
- The term haematopoietic stem cell (HSC) refers to cells made in the blood factory or bone marrow that have the potential to grow into almost any type of blood cell. (thedailystar.net)
- 1 During the 1970s, it was recognised that UCB contains haematopoietic progenitor cells. (mja.com.au)
- Nevertheless, because of certain biological properties of UCB compared with bone marrow, UCB cells will grow or "engraft" in most patients and result in reconstitution of the haematopoietic and immune cells. (mja.com.au)
- or allogeneic SCT (in which compatible donor cells are transplanted). (bio-medicine.org)
- If enough stem cells are harvested from a compatible donor, they can be transplanted to the patient. (lls.org)
- 8 The likelihood of finding a compatible donor is even less for ethnic minority groups, which are poorly represented in the registries. (mja.com.au)
- Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. (clinicaltrials.gov)
- Here, microRNAs (miRs) represent an interesting tool since miRs have been recently reported to be an important regulator of various cells, including immune cells such as T cells. (springer.com)
- In the general population, older age is associated with short telomere length in peripheral blood leukocytes and with high risk of infections, 5 - 7 but it is currently unknown whether short leukocyte telomere length is a cause of impaired immune competence. (haematologica.org)
- We have advanced, dedicated bone marrow transplant units offering personal monitoring and special airflow systems for patients with weakened immune systems. (nyp.org)
- Stem cells collected from the donor will be processed using a new device called CliniMACS CD34 Reagent System which marks the blood cells collected from the donor with a special protein called "antibody" that tags only the donor stem cells, sorting out other cells of the blood and immune system. (bioportfolio.com)
- It relies instead on the killing action of the donor s immune cells to eradicate the remaining disease. (lymphomation.org)
- Giving zoledronic acid after the transplant may help strengthen the immune system and make the immune cells work better. (cancer.gov)
- Without stem cells, the body cannot make the blood cells needed for the immune system to function. (blood.ca)
- Czechowicz A and Weissman I. Purified Hematopoietic Stem Cell Transplantation - The Next Generation of Blood and Immune Replacement. (medindia.net)
- Subsequently, he's honing in on immunotherapy-a method of treatment that focuses on triggering the body's immune system to recognize and respond to cancerous cells. (hopkinsmedicine.org)
- Vasoactive intestinal peptide (VIP) induces regulatory dendritic cells (DC) in vitro that inhibit cellular immune responses. (jimmunol.org)
- We tested the role of physiological levels of VIP on immune responses to murine CMV (mCMV) using VIP-knockout (VIP-KO) mice and radiation chimeras engrafted with syngenic VIP-KO hematopoietic cells. (jimmunol.org)
- mCMV-immune VIP-KO mice had enhanced ability to clear mCMV peptide-pulsed target cells in vivo. (jimmunol.org)
- Because the absence of VIP in immune cells increased innate and adaptive antiviral immunity by altering costimulatory and coinhibitory pathways, selective targeting of VIP signaling represents an attractive therapeutic target to enhance antiviral immunity. (jimmunol.org)
- Vasoactive intestinal peptide (VIP) is a multifunctional endogenous polypeptide that modulates both innate and adaptive immunity at multiple levels of immune cell differentiation and activation ( 1 ). (jimmunol.org)
- In adaptive immune responses, VIP polarizes CD4 + T cells to an immunosuppressive Th2 response while suppressing the Th1 responses ( 9 ). (jimmunol.org)
- The goal of this study is to replace the abnormal immune cells of the SLE affected patient that causes the disease with normal immune cells that are generated from the transplant blood stem cells from the healthy donor. (clinicaltrials.gov)
- There he focused on the role of the immune system's cells and their activation mechanism via intra- cellular signals. (isracast.com)
- In 1991, Prof. Or established a research laboratory at Hadassah medical center to study immune reconstitution following bone marrow transplantation. (isracast.com)
- These experiences proved that cells from a donor's immune system have a strong biological ability to attack cancerous cells which remain in the patient following the transplant. (isracast.com)
- On that basis, a new immune cell therapy was developed and used to treat severe cases which were previously considered untreatable. (isracast.com)
- In 1993, the first Australian UCB transplant was performed at Sydney Children's Hospital, Randwick, in a child with an immune deficiency. (mja.com.au)
- The UCSD researchers also documented the stepwise formation of HSCs from "hemogenic" aortic endothelium and showed, by expressing a permanent fluorescent marker in these cells, that all adult blood and immune cell types derive from aortic endothelium of the early embryo. (scienceblog.com)
- Immune cells are taken directly from a patient and genetically modified to be better tumor-fighting immune cells. (northside.com)
- Removing immune system T-cells from the blood stream. (northside.com)
- Effector functions of NK cells include direct natural cytotoxicity, antibody-dependent cellular cytotoxicity (ADCC), as well as secretion of inflammatory cytokines and chemokines that indirectly regulate the functions of other immune cells 2 , 3 . (jcancer.org)
- NK cells both modulate the immune system as well as mediate direct killing of malignant or infected cells. (jcancer.org)
- Because the donor newborn's immune system is still immature, the stem cells are less likely to induce an adverse immune reaction in the receiver. (cmaj.ca)
- 2 This activation of T-cells can result in severe immune-mediated tissue damage to the host, with the skin, liver and gastrointestinal tract being the most common targets. (pipelinereview.com)
- Allogeneic hematopoietic stem cell transplantation (HCT) is a well-established treatment for many malignant and non-malignant hematological disorders. (springer.com)
- Though many inherited blood disorders themselves cannot be cured, our team of experts has designed a treatment approach that can effectively cure the bone marrow failure associated with many of these disorders. (mskcc.org)
- (1) We have also performed dozens of transplants for people with the inherited blood disorders beta-thalassemia and sickle cell disease. (mskcc.org)
- Only about 30% of patients with blood disorders will have a compatible bone marrow donor in their families. (genengnews.com)
- Alternative-Donor Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide for Nonmalignant Disorders. (hopkinsmedicine.org)
- As in human medicine, adult mesenchymal stem cells (MSCs) play an important role in veterinary medicine for the treatment of acute injury and chronic disorders. (hindawi.com)
- It is hoped and expected that, in the future, cord blood stem cells will be used to treat many other disorders, including Alzheimer's disease, diabetes , heart disease, liver disease, muscular dystrophy, Parkinson's disease (a neurological illness), spinal cord injury and stroke. (womenfitness.net)
- Gene-therapy research involving modification of autologous cord blood stem cells for the treatment of childhood genetic disorders, although experimental at the present time, may prove to be of value. (aappublications.org)
- 5 - 7 The condition is characterized typically by an early onset of hepatosplenomegaly, fever, neurologic symptoms, blood coagulation disorders, and the infiltration of many organs, including the central nervous system (CNS), by polyclonally activated CD8 T lymphocytes and activated macrophages. (aappublications.org)
- Abstract Thalassemia syndromes are a group of inherited blood disorders caused by limitation or absence of alpha or beta- globin chain synthesis resulting in ineffective erythropoiesis and chronic hemolytic anemia. (medworm.com)
- Relapse of AML was diagnosed 14 months after the transplantation. (hindawi.com)
- Bone marrow transplantation is most effective when started soon after relapse. (doctors-hospital.net)
- Still, nearly half of patients relapse after undergoing a transplant, and others are not candidates for transplantation because of advanced illness or the lack of a suitable donor, Braun said. (ucsf.edu)
- HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry. (nature.com)
- Because only 25% of patients have a suitable sibling donor, an International Unrelated Donor Registry of over 7 million healthy volunteers has been created. (cmaj.ca)
- People can join the Be The Match Registry the world s largest listing of potential marrow donors and donated cord blood units contribute financially and volunteer. (lymphomation.org)
- You could be a hero to a patient in need by joining Canada's national stem cell registry or, if you're an expectant mother, consenting to donate cord blood. (blood.ca)
- Learn about Canadian Blood Services Stem Cell Registry, donor eligibility, important registration information, how stem cell donation works and more. (blood.ca)
- We need more healthy Canadians between 17 and 35 years of age to join our stem cell registry. (blood.ca)
- A current list of allogeneic transplantation indications and timing for referral can be found in The National Marrow Donor Program's ''Be The Match"' Donor Registry (see references). (psychiatryadvisor.com)
- Within the NMDP registry, the probability of identifying at least one antigen level-matched (HLA-A and -B) and potential allele level-matched (HLA-DRB1) donor depends upon race/ethnicity. (psychiatryadvisor.com)
- Most donors in the registry are partially matched at HLA A and B. The HapLogic algorithm in the NMDP utilizes extended HLA typing for haplotype analysis to predict the donor's DRB1 type and narrow the list of potential unrelated donors. (psychiatryadvisor.com)
- The NMDP Registry is thelargest, most diverse registry of potentialhematopoietic stem cell donorsin the world. (cancernetwork.com)
- Toprovide patients of every ethnic communitya better chance at finding amatched donor, the NMDP has ongoingrecruitment programs to bringmore African-American, AmericanIndian/Alaska Native, Asian/PacificIslander, and Hispanic donors to theNMDP Registry. (cancernetwork.com)
- All cord blood unitsat NMDP cord blood banks are listedin the NMDP Registry and are automaticallyincluded in every patientsearch. (cancernetwork.com)
- Even with a registry of diverse donors like Canadian Blood Services' OneMatch , which has connections to millions of donors worldwide, many Canadian patients are not able to find a suitable stem cell donor. (blood.ca)
- No members of Walsh's family were a match for her, but a willing donor was found through the national registry. (cbslocal.com)
- With over 3.8 million registered donors, DKMS is the world's largest stem cell registry. (parentsguidecordblood.org)
- However, in Ukraine, there is no access to a donor registry. (parentsguidecordblood.org)
- 2 , 6 , 11 There are more than 7 million potential unrelated volunteer adult donors registered in the National Marrow Donor Program registry. (aappublications.org)
- JSHCT played a central role in developing the 'Transplant Registry Unified Management Program (TRUMP)' to enable transplantation institutes to manage patient information with emphases on convenience to institutes, safety of patient information, and quality of data management. (omicsonline.org)
- The BMDW Editorial Board consists of one representative of each stem cell donor registry or cord blood bank participating in BMDW, and meets twice a year to discuss achievements and necessary improvements. (wikipedia.org)
- Joining BMDW database requires a registry to be fully operational, and must have at least 50 HLA-typed unrelated stem cell donors or cord blood units. (wikipedia.org)
- For further details on the number of Donors/Cord Blood Units (CBU) per registry within the BMDW database click here. (wikipedia.org)
- It also operates a national panel of unrelated potential blood stem cell donors - the Welsh Bone Marrow Donor Registry. (wikipedia.org)
- Reduced-intensity versus myeloablative conditioning in cord blood transplantation for AML (40-60 years) across highly mismatched HLA barriers - On behalf of Eurocord and the Cellular Therapy & Immunobiology Working Party (CTIWP) of EBMT. (stembook.org)
- Risk factors for 30-day hospital readmission following myeloablative allogeneic hematopoietic cell transplantation (allo-HCT). (springer.com)
- Baron F, Storb R (2004) Allogeneic hematopoietic cell transplantation as treatment for hematological malignancies: a review. (springer.com)
- Here, we examine the outcome of patients with lymphoid malignancies undergoing haplo-cord transplantation at the University of Chicago and Weill Cornell Medical College. (unboundmedicine.com)
- In conclusion, haplo-cord transplantation offers a transplant alternative for patients with recurrent or refractory lymphoid malignancies who lack matching donors. (unboundmedicine.com)
- Stem cell transplants have been shown to be an effective treatment for aggressive leukemias and other hematological malignancies, often representing the only therapeutic option for cure. (pipelinereview.com)
- On 21 September 2017, the first public (donor) bank of cord blood, founded by the Bank of Life Charitable Foundation, started its work in Ukraine. (parentsguidecordblood.org)
- On 1st January 2017 BMDW merged with NetCord and has become a service of the World Marrow Donor Association (WMDA). (wikipedia.org)
- In 2017 the Welsh Blood Service published its Research and Development Strategy, (available in Welsh, Gwasanaeth Gwaed Cymru Strategaeth Ymchwil a Datblygu) which details its planned expansion of activity into collaborative work and engaging in regenerative and personalised medicine fields. (wikipedia.org)