C22-unsaturated fatty acids found predominantly in FISH OILS.
Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.
FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.
A fatty acid that is found in plants and involved in the formation of prostaglandins.
Oils high in unsaturated fats extracted from the bodies of fish or fish parts, especially the LIVER. Those from the liver are usually high in VITAMIN A. The oils are used as DIETARY SUPPLEMENTS. They are also used in soaps and detergents and as protective coatings.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
FATTY ACIDS which have the first unsaturated bond in the sixth position from the omega carbon. A typical American diet tends to contain substantially more omega-6 than OMEGA-3 FATTY ACIDS.
An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Unsaturated fats or oils used in foods or as a food.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
Long chain organic acid molecules that must be obtained from the diet. Examples are LINOLEIC ACIDS and LINOLENIC ACIDS.
A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)
Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.
The fixed oil obtained from the dried ripe seed of linseed, Linum usitatissimum (L. Linaceae). It is used as an emollient in liniments, pastes, and medicinal soaps, and in veterinary medicine as a laxative. It is also called flaxseed oil. (Dorland, 28th ed)
Oils derived from plants or plant products.
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
Marine fish and shellfish used as food or suitable for food. (Webster, 3d ed) SHELLFISH and FISH PRODUCTS are more specific types of SEAFOOD.
Regular course of eating and drinking adopted by a person or animal.
A family of enzymes that catalyze the stereoselective, regioselective, or chemoselective syn-dehydrogenation reactions. They function by a mechanism that is linked directly to reduction of molecular OXYGEN.
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
An oily liquid extracted from the seeds of the safflower, Carthamus tinctorius. It is used as a dietary supplement in the management of HYPERCHOLESTEROLEMIA. It is used also in cooking, as a salad oil, and as a vehicle for medicines, paints, varnishes, etc. (Dorland, 28th ed & Random House Unabridged Dictionary, 2d ed)
Common name for various species of large, vigorous ocean fishes in the family Scombridae.
A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Eighteen-carbon essential fatty acids that contain three double bonds.
Oil obtained from fresh livers of the cod family, Gadidae. It is a source of VITAMIN A and VITAMIN D.
Oil from soybean or soybean plant.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.
A common name (but used formally) for a group of organisms that are mostly kinds of algae including BACILLARIOPHYTA; OOMYCETES; PHAEOPHYCEAE; and CHRYSOPHYCEAE. They all contain CHLOROPLASTS that are thought to have been derived from the endosymbiosis of ancient RED ALGAE.
Food processed and manufactured for the nutritional health of children in their first year of life.
An early onset form of phytanic acid storage disease with clinical and biochemical signs different from those of REFSUM DISEASE. Features include MENTAL RETARDATION; SENSORINEURAL HEARING LOSS; OSTEOPOROSIS; and severe liver damage. It can be caused by mutation in a number of genes encoding proteins involving in the biogenesis or assembly of PEROXISOMES.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.
Liquid formulations for the nutrition of infants that can substitute for BREAST MILK.
Oil from ZEA MAYS or corn plant.
Food products manufactured from fish (e.g., FISH FLOUR, fish meal).
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Nutrition of a mother which affects the health of the FETUS and INFANT as well as herself.
A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.
Nutritional physiology of children from birth to 2 years of age.
A series of prostaglandin-like compounds that are produced by the attack of free-radical species on unsaturated fatty acids, especially ARACHIDONIC ACID, of cellular MEMBRANES. Once cleaved from the lipid membrane by the action of phospholipases they can circulate into various bodily fluids and eventually be excreted. Although these compounds resemble enzymatically synthesized prostaglandins their stereoisometric arrangement is usually different than the "naturally occurring" compounds.
GLYCEROPHOSPHOLIPIDS in which one of the two acyl chains is attached to glycerol with an ether alkenyl linkage instead of an ester as with the other glycerophospholipids.
An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed)
An enzyme that catalyzes the syn-dehydrogenation of linoleol-CoA gamma-linolenoyl-CoA. It was formerly characterized as EC
Eighteen-carbon essential fatty acids that contain two double bonds.
An autosomal recessive disorder due to defects in PEROXISOME biogenesis which involves more than 13 genes encoding peroxin proteins of the peroxisomal membrane and matrix. Zellweger syndrome is typically seen in the neonatal period with features such as dysmorphic skull; MUSCLE HYPOTONIA; SENSORINEURAL HEARING LOSS; visual compromise; SEIZURES; progressive degeneration of the KIDNEYS and the LIVER. Zellweger-like syndrome refers to phenotypes resembling the neonatal Zellweger syndrome but seen in children or adults with apparently intact peroxisome biogenesis.
A class of compounds named after and generally derived from C20 fatty acids (EICOSANOIC ACIDS) that includes PROSTAGLANDINS; LEUKOTRIENES; THROMBOXANES, and HYDROXYEICOSATETRAENOIC ACIDS. They have hormone-like effects mediated by specialized receptors (RECEPTORS, EICOSANOID).
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Nutrition of FEMALE during PREGNANCY.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Food and dietary formulations including elemental (chemically defined formula) diets, synthetic and semisynthetic diets, space diets, weight-reduction formulas, tube-feeding diets, complete liquid diets, and supplemental liquid and solid diets.
A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
Derivatives of phosphatidic acid in which the hydrophobic regions are composed of two fatty acids and a polar alcohol is joined to the C-3 position of glycerol through a phosphodiester bond. They are named according to their polar head groups, such as phosphatidylcholine and phosphatidylethanolamine.
Compounds that inhibit or block the activity of a PHOSPHOLIPASE A2 enzyme.
An enzyme of the oxidoreductase class primarily found in PLANTS. It catalyzes reactions between linoleate and other fatty acids and oxygen to form hydroperoxy-fatty acid derivatives.
The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.
The portion of a retinal rod cell situated between the ROD INNER SEGMENT and the RETINAL PIGMENT EPITHELIUM. It contains a stack of photosensitive disk membranes laden with RHODOPSIN.
Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.
The amounts of various substances in food needed by an organism to sustain healthy life.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5,8,11,13-eicosatetraenoate (15-HETE). The 15-hydroperoxides are preferentially formed in NEUTROPHILS and LYMPHOCYTES.
Inorganic compounds that contain ruthenium as an integral part of the molecule.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Any food that has been supplemented with essential nutrients either in quantities that are greater than those present normally, or which are not present in the food normally. Fortified food includes also food to which various nutrients have been added to compensate for those removed by refinement or processing. (From Segen, Dictionary of Modern Medicine, 1992)
A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids. (Stedman, 25th ed)
Compounds in which one or more of the ketone groups on the pyrimidine ring of barbituric acid are replaced by thione groups.
An order of pelagic, shrimplike CRUSTACEA. Many consume ZOOPLANKTON and a few are predacious. Many antarctic species, such as Euphausia superba, constitute the chief food of other animals.
FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form.
Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.

Effects of docosahexaenoic and eicosapentaenoic acid on lipid metabolism, eicosanoid production, platelet aggregation and atherosclerosis in hypercholesterolemic rats. (1/1678)

Exogenously hypercholesterolemic (ExHC) rats were fed on an atherogenic diet supplemented with 1% each of either ethyl ester docosahexaenoic acid [EE-DHA, 22:6(n-3)], ethyl ester eicosapentaenoic acid [EE-EPA, 20:5(n-3)] or safflower oil (SO) for 6 months. The rats fed on the diets containing EE-EPA or EE-DHA, compared with those fed on SO, had lower serum cholesterol and triacylglycerol levels, less aggregation of platelets and slower progress of intimal thickening in the ascending aorta. Relative to the SO-fed rats, both of the (n-3) fatty acid-fed rats had a significantly reduced proportion of arachidonic acid in the platelet and aortic phospholipids, and lower production of thromboxane A2 by platelets and of prostacyclin by the aorta. These results suggest that EPA and DHA are similarly involved in preventing atherosclerosis development by reducing hypercholesterolemia and modifying the platelet functions.  (+info)

Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats. (2/1678)

The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.  (+info)

Plasmalogen status influences docosahexaenoic acid levels in a macrophage cell line. Insights using ether lipid-deficient variants. (3/1678)

Previously, this laboratory reported the isolation of variants, RAW. 12 and RAW.108, from the macrophage-like cell line RAW 264.7 that are defective in plasmalogen biosynthesis [Zoeller, R.A. et al. 1992. J. Biol. Chem. 267: 8299-8306]. Fatty acid analysis showed significant changes in the mutants in the ethanolamine phospholipids (PE), the only phospholipid class in which the plasmalogen species, plasmenylethanolamine, contributes significantly. Within the PE fraction, docosapentaenoic (DPA; 22:5n-3) and docosahexaenoic (DHA; 22:6n-3) acids were reduced by approximately 50% in the variants while the levels of arachidonic acid (AA; 20:4n-6) remained unaffected. The decrease in DHA was accompanied by a 50% decrease in labeling PE with [3H]DHA over a 90-min period. Restoration of plasmenylethanolamine by supplementing the growth medium with sn -1-hexadecylglycerol (HG) completely reversed these changes in RAW. 108. Pre-existing pools of plasmenylethanolamine were not required for restoration of normal [3H]DHA labeling; addition of HG only during the labeling period was sufficient. Due to the loss of Delta1'-desaturase in RAW.12, HG supplementation resulted in the accumulation of plasmenylethanolamine's immediate biosynthetic precursor, plasmanylethanolamine. Even though this latter phospholipid contained only the ether functionality (lacking the vinyl ether double bond) it was sufficient to restore wild type-like fatty acid composition and DHA labeling of the ethanolamine phospholipids, identifying the ether bond as a structural determinant for this specificity. In summary, we have used these mutants to establish that the plasmalogen status of a cell can influence the levels of certain polyunsaturated fatty acids. These results support the notion that certain polyunsaturated fatty acids, such as DHA, can be selectively targeted to plasmalogens and that this targeting occurs during de novo biosynthesis, or shortly thereafter, through modification of nascent plasmalogen pools.  (+info)

Fish oil constituent docosahexa-enoic acid selectively inhibits growth of human papillomavirus immortalized keratinocytes. (4/1678)

The omega-3-fatty acids inhibit proliferation of breast cancer cells whereas omega-6-fatty acids stimulate growth. In this study, we examined effects of these fatty acids on human pre-cancerous cells. Cervical keratinocytes, immortalized with the oncogenic human papillomavirus (HPV) type 16, were treated with linoleic acid, an omega-6-fatty acid, and the omega-3-fatty acids, eicosapentaenoic and docosahexaenoic acids. Using both cell counts and bromodeoxyuridine incorporation, docosahexaenoic acid inhibited growth of these cells to a greater extent than eicosapenta-enoic acid. Linoleic acid had no effect. The effect of docosahexaenoic acid was dose dependent and caused growth arrest. Docosahexaenoic acid inhibited growth of HPV16 immortalized foreskin keratinocytes and laryngeal keratinocytes grown from explants of benign tumors caused by papillomavirus, but had no effect on normal foreskin and laryngeal keratinocytes. Docosahexaenoic acid inhibited growth in the presence of estradiol, a growth stimulator for these cells. Indomethacin, a cyclooxygenase inhibitor like docosahexaenoic acid, had only minimal effect on growth. Alpha-tocopherol, a peroxidation inhibitor, abrogated effects of docosahexaenoic acid implying that inhibitory effects were via lipid peroxidation.  (+info)

Effect of prostanoids and their precursors on the aggregation of rainbow trout thrombocytes. (5/1678)

The role of prostanoids and their precursor fatty acids in the aggregatory response of thrombocytes (platelet equivalents of fish) from the rainbow trout, Oncorhynchus mykiss, was studied. Aggregation of these cells was induced by the thromboxane mimetic U-46619 or arachidonic acid (AA) in the presence of human or trout fibrinogen. The production of TXB2/3 by thrombocytes in response to stimulation with AA was inhibited by aspirin, ibuprofen, and indomethacin. However, thrombocyte aggregation in response to AA stimulation was not significantly altered by these agents at the concentrations tested (10-100 microM), with the exception of indomethacin at 20 and 40 microM. Effects on cytosolic calcium concentration have been suggested as an alternative mechanism for the inhibitory action of indomethacin on human platelet aggregation. The present study, however, failed to identify this as a mechanism for the inhibition of U-46619-induced trout thrombocyte aggregation by indomethacin. The polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid both exhibited an inhibitory effect on U-46619-induced thrombocyte aggregation similar to that observed with mammalian platelets. Unlike the case in mammalian hemostasis, prostacyclin inhibited thrombocyte aggregation only at high concentrations (>5 microM). Prostaglandin E2, however, inhibited thrombocyte aggregation at much lower concentrations (>0.01 microM), suggesting that it may be the major inhibitory eicosanoid in trout.  (+info)

Activation of NADPH oxidase by docosahexaenoic acid hydroperoxide and its inhibition by a novel retinal pigment epithelial protein. (6/1678)

PURPOSE: In an earlier study, a novel retinal pigment epithelial protective protein (RPP) was described, which suppresses the superoxide generation of activated polymorphonuclear leukocytes (PMNs). In experimental autoimmune uveitis, docosahexaenoic acid hydroperoxide (22:6OOH) has been shown to be the major lipid peroxidation product in photoreceptors. This hydroperoxide was also found to be chemotactic to PMNs. This study was undertaken to evaluate the activation capability of 22:6OOH in resting PMNs and the possible inhibition of this activation by RPP. METHODS: The 22:6OOH was obtained from pure 22:6 and was purified by thin-layer and high-performance liquid chromatography. Intact rabbit peritoneal PMNs (7-8 X 10(5)) were coincubated with 0.5 microM formyl-methionyl-leucyl-phenylalanine (fMLP), 1.3 microM 22:6OOH, or 5.0 microM 22:6. These systems were coincubated with and without 0.25 microg/ml RPP. From PMN cell-free preparations, the reconstitutes each containing 21 microg plasma membranes and 276 microg cytosolic factors were coincubated with arachidonate, 22:6OOH, or 22:6, each at 100 microM. The inhibition of superoxide production was estimated by adding 0.20 microg/ml RPP. Superoxide generation was measured by superoxide dismutase-inhibitable cytochrome C reduction. RESULTS: In 30 minutes, 22:6OOH-activated PMNs produced 11.10 +/- 0.68 nanomoles superoxide, and production was suppressed 72% by RPP. Under the same conditions, fMLP induced production of 34.6 +/- 2.77 nanomoles superoxide, and RPP inhibited 60% of production. In the PMN cell-free systems, 100 microM 22:6OOH induced 74.7 nanomoles superoxide per milligram plasma membrane proteins per 5 minutes, and RPP suppressed 50% of production. These results were comparable with those generated by arachidonate, a known stimulator for this system. RPP was effective only when it was added before assembly of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. CONCLUSIONS: The inflammation-mediated retinal peroxidation product 22:6OOH significantly activates resting PMNs, either in intact cells or in cell-free preparations, to increase further the release of superoxide from PMNs, thus accelerating inflammation-mediated tissue damage. This profound amplification process seems to be effectively downregulated by an RPE-generated protein RPP.  (+info)

Concentration of serum lipids and aortic lesion size in female and male apo E-deficient mice fed docosahexaenoic acid. (7/1678)

Apolipoprotein (apo) E-deficient mice were fed an atherogenic diet with either 1% ethyl ester docosahexaenoic acid (DHA) or safflower oil (SO) as a source of linoleic acid for 8 week. Both genders fed DHA had higher proportions of eicosapentaenoic acid and DHA, and lower proportions of linoleic and arachidonic acids in the liver and serum phospholipids than those fed SO. Males fed DHA had greater liver weight and tended to have higher concentrations of serum lipids and liver cholesterol than those fed SO, and there were opposite trends in females. Dietary fats and gender led to no significant effect on lesion sizes in aortic arch and thoracic plus abdominal aorta. These results indicate that the interactive action of sex-related factor(s) with dietary polyunsaturated fatty acids is involved in metabolic changes of serum lipids in apoE-deficient mice, and addition of DHA, compared with addition of SO, is not effective to abolish the atherosclerosis in this animal model.  (+info)

Cytotoxic drugs efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. (8/1678)

Experimental studies indicated that long-chain polyunsaturated fatty acids may increase sensitivity of mammary tumours to several cytotoxic drugs. To evaluate this hypothesis in breast cancer, we have prospectively studied the association between levels of fatty acids stored in breast adipose tissue and the response of the tumour to chemotherapy in 56 patients with an initially localized breast carcinoma. Adipose breast tissue was obtained at the time of biopsy, and individual fatty acids were measured as a percentage of total fatty acids using capillary gas chromatography. Patients then received primary chemotherapy, combining mitoxantrone, vindesine, cyclophosphamide and 5-fluorouracil every 4 weeks. Tumour size was reassessed after three cycles of chemotherapy. Tumour response was evaluated according to World Health Organization criteria. Complete or partial response to chemotherapy was achieved in 26 patients (47%). Level of n-3 polyunsaturated fatty acids in adipose tissue was higher in the group of patients with complete or partial response to chemotherapy than in patients with no response or with tumour progression (P < 0.004). Among n-3 polyunsaturated, only docosahexaenoic acid (22:6n-3) was significantly associated with tumour response (P < 0.005). In a logistic regression analysis taking into account age, body mass index and tumour size, 22:6 n-3 level proved to be an independent predictor for chemosensitivity (P = 0.03). These results suggest that, in breast cancer, 22:6 n-3 may increase the response of the tumour to the cytotoxic agents used.  (+info)

TY - JOUR. T1 - Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. AU - Song, Jin Hyang. AU - Miyazawa, Teruo. PY - 2001. Y1 - 2001. N2 - The effect of dietary docosahexaenoic acid (DHA, 22:6n-3) oil with different lipid types on lipid peroxidation was studied in rats. Each group of male Sprague-Dawley rats was pair fed 15% (w/w) of either DHA-triglycerides (DHA-TG), DHA-ethyl esters (DHA-EE) or DHA-phospholipids (DHA-PL) for up to 3 weeks. The palm oil (supplemented with 20% soybean oil) diet without DHA was fed as the control. Dietary DHA oils lowered plasma triglyceride concentrations in rats fed DHA-TG (by 30%), DHA-EE (by 45%) and DHA-PL (by 27%), compared to control. The incorporation of dietary DHA into plasma and liver phospholipids was more pronounced in the DHA-TG and DHA-EE group than in the DHA-PL group. However, DHA oil intake negatively influenced lipid peroxidation in both plasma and liver. ...
TY - JOUR. T1 - Effect of docosahexaenoic acid supplementation on inflammatory cytokine levels in infants at high genetic risk for type 1 diabetes. AU - The Type 1 Diabetes TrialNet Nutritional Intervention to Prevent (NIP) Type 1 Diabetes Study Group. AU - Chase, H. Peter. AU - Boulware, David. AU - Rodriguez, Henry. AU - Donaldson, David. AU - Chritton, Sonia. AU - Rafkin, Lisa. AU - Krischer, Jeffrey. AU - Skyler, Jay S. AU - Clare-Salzler, Michael. AU - Lescheck, E.. AU - Krause Steinrauf, H.. AU - Azare, S. M.. AU - Adams, S.. PY - 2015/6/1. Y1 - 2015/6/1. N2 - Objective: Type 1 diabetes (T1D) results from the inflammatory destruction of pancreatic β-cells. In this study, we investigated the effect of docosahexaenoic acid (DHA) supplementation on stimulated inflammatory cytokine production in white blood cells (WBC) from infants with a high genetic risk for T1D. Research design and methods: This was a multicenter, two-arm, randomized, double-blind pilot trial of DHA supplementation, ...
Patients with Uncontrolled Epilepsy Have Low Levels of Fatty Acids Omega-3 fatty acids are crucial to the proper development and function of cell membranes...
From what Ive read the only strain of Epilepsy which can cause sudden death is status epilepticus. Very rare. I dont know if it falls as high as 20...
The complexities of cell function in the central nervous system are sustained by intra- and intercellular signaling networks driven by synaptic activity, neurotrophins, gene programs and other factors. The molecular organization and functional contribution of cellular membranes are pivotal in the myriad of molecular circuitries of the CNS. Docosahexaenoic acid, an omega-3 fatty acid, is concentrated and avidly retained in membrane phospholipids of the nervous system, notably in photoreceptors and synapses. DHA is implicated in brain and retina function, aging, and neurological and psychiatric/behavioral illnesses. The discovery of neuroprotectin D1, the first docosanoid (a bioactive derivative of DHA), is allowing scientists to address fundamental questions concerning the biology of omega-3 fatty acids and their significance to brain function and the mechanisms of action in disease models such as stroke, epilepsy and neurodegeneration. The name neuroprotectin D1 was suggested based on the ...
Docosahexaenoic acid supplementation promotes erythrocyte antioxidant defense and reduces protein nitrosative damage in male athletes.
Protectin D1 also known as neuroprotectin D1 (when it acts in the nervous system) and abbreviated most commonly as PD1 or NPD1 is a member of the class of specialized proresolving mediators. Like other members of this class of polyunsaturated fatty acid metabolites, it possesses strong anti-inflammatory, anti-apoptotic and neuroprotective activity. PD1 is an aliphatic acyclic alkene 22 carbons in length with two hydroxyl groups at the 10 and 17 carbon positions and one carboxylic acid group at the one carbon position. Specifically, PD1 is an endogenous stereoselective lipid mediator classified as an autocoid protectin. Autacoids are enzymatically derived chemical mediators with distinct biological activities and molecular structures. Protectins are signaling molecules that are produced enzymatically from unsaturated fatty acids. Their molecular structure is characterized by the presence of a conjugated system of double bonds. PD1, like other protectins, is produced by the oxygenation of the ω-3 ...
OBJECTIVE To hypothesize that higher intake of docosahexaenoic acid, an n-3 long chain polyunsaturated fatty acid, would increase duration of gestation and birth weight in US women. METHODS This was a randomized, double-blind, controlled, clinical trial. Subjects were enrolled in an ambulatory clinic where they received prenatal care. This was a population-based sample. Most subjects received government assistance for medical care and most were black (73%). Subjects were enrolled between the 24th and 28th week of pregnancy and consumed docosahexaenoic acid (33 or 133 mg) from eggs until parturition. Gestational age and birth weight were the main study outcomes. Infant length and head circumference, preterm birth, and low birth weight were secondary outcomes. RESULTS Eighty-three percent of subjects completed the study (291 of 350 enrolled). No subject was discontinued for an adverse event. After controlling for important predefined risk factors and confounding variables, gestation increased by 6.0 +
TY - JOUR. T1 - Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients. AU - Kale, Anvita. AU - Joshi, Sadhana. AU - Naphade, Nilesh. AU - Sapkale, Swati. AU - Raju, M. S.V.K.. AU - Pillai, Anilkumar R. AU - Nasrallah, Henry. AU - Mahadik, Sahebarao P.. PY - 2008/1/1. Y1 - 2008/1/1. N2 - Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p = , 0.01) whereas higher in CSF (p = , 0.01) in male , female patients. This altered DHA ...
Low levels of the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) have been reported in the brains of patients with Alzheimers disease (AD), as has evidence for an AD protective effect of increased marine fish consumption, a main source of DHA. This week, Lim et al. test whether DHA has a direct effect on amyloid production in a mouse model of AD. The studies support a role for DHA in reducing amyloid burden even at a relatively late stage in this animal model.
article{75fb11cd-9b79-4275-9d9c-4adabc269474, abstract = {PURPOSE:: To examine the retinal inflammatory response to ischemia-reperfusion in nondiabetic and diabetic rats injected with either an omega-3-polyunsaturated fatty acid (docosahexaenoic acid [DHA]) or a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (pravastatin). METHODS:: Diabetes was induced by an intraperitoneal injection of streptozocin, and retinal ischemia was induced by ligation of the optic nerve and vessels, followed by reperfusion for 1 hour or 24 hours. Five minutes before surgery, an intravenous injection of DHA, pravastatin, or vehicle (ethanol) was administered. The mRNA expressions of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, caspase-1, IL-1beta, P-selectin, vascular cellular adhesion molecule (VCAM)-1, and intercellular adhesion molecule (ICAM)-1 were compared between ischemic and nonischemic retinas as well as diabetic and nondiabetic nonischemic retinas. RESULTS:: Ischemia induced increased ...
Effects of docosahexaenoic acid on large-conductance Ca2+-activated K+ channels and voltage-dependent K+ channels in rat coronary artery smooth muscle cells.: D
Marine oils are important to human nutrition as the major source of docosahexaenoic acid (DHA), a key omega-3 long-chain (≥C20) polyunsaturated fatty acid (n-3 LC-PUFA) that is low or lacking in terrestrial plant or animal oils. The inclusion of fish oil as main source of n-3 LC-PUFA in aquafeeds is mostly limited by the increasing price and decreasing availability. Fish oil replacement with cheaper terrestrial plant and animal oils has considerably reduced the content of n-3 LC-PUFA in flesh of farmed Atlantic salmon. Novel DHA-enriched oils with high alpha-linolenic acid (ALA) content will be available from transgenic oilseeds plants in the near future as an alternative for dietary fish oil replacement in aquafeeds. As a preliminary validation, we formulated an oil blend (TOFX) with high DHA and ALA content using tuna oil (TO) high in DHA and the flaxseed oil (FX) high in ALA, and assessed its ability to achieve fish oil-like n-3 LC-PUFA tissue composition in Atlantic salmon smolts. We ...
By a News Reporter-Staff News Editor at VerticalNews Science -- DURHAM, N.C. - Physicians and patients who are wary of addiction to pain medication and opioids may soon have a healthier and more natural alternative. A Duke University study revealed that a derivative of DHA (docosahexaenoic acid), a main ingredient of over-the-counter fish oil supplements, can sooth and prevent neuropathic pain caused by injuries to the sensory system. The results appear online in the Annals of Neurology. The research focused on a compound called neuroprotectin D1=protectin D1 (NPD1=PD1), a bioactive lipid produced by cells in response to external stimuli. NPD1=PD1 is present in human white blood cells, and was first identified based on its ability to resolve abdominal and brain inflammation. These compounds are derived from omega-3 fatty acids found in fish oil, but are 1,000 times more potent than their precursors in reducing inflammation, said Ru-Rong Ji, professor of anesthesiology and neurobiology at Duke ...
Some evidence shows that fetal development may be a critical for the development of allergies and asthma later in life, and that DHA may play a key role in the development of the immune system. This study aimed to investigate the effects of DHA supplementation during this time period on the incidence of allergies and asthma up to six years of age. Women in the KUDOS cohort were given 600 mg of DHA or a placebo during their second and third trimesters of pregnancy, and their offspring were followed up to six years of age. Two-hundred thirty infants were included. Their medical records were collected until six years of age or until their records could no longer be acquired if the infant dropped out before six years of age. All records were coded and allergic diagnoses were examined for this study. These diagnoses were grouped into three categories, skin allergies, wheeze/asthma, and other allergies. Associations and relative risks were calculated for each type of allergy diagnosis and no ...
Dendritic cells (DC) are professional antigen presenting cells which link innate and adaptive immunity through recognition and processing of pathogens, migration to secondary lymph nodes, presentation of antigens to naïve T cells and contribution to T cell proliferation and differentiation into various classes of effector T cells. N-3 fatty acids including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were reported to have protective anti-inflammatory effects in clinical studies and animal models of colitis, sepsis, and stroke. However, the mechanisms involved in the anti-inflammatory function of EPA and DHA are not elucidated. Recent studies, including our own, investigated the effect of n-3 fatty acids on dendritic cells, and reported that DHA reduced the capacity of human monocyte-derived DC (hMo-DC) and of murine bone marrow derived conventional DC (BMDC) to produce IL-12 and to stimulate CD4+ T cell proliferation. The objectives of this thesis were to provide a comprehensive ...
Uncoupling protein 3 (UCP3) is a mitochondrial membrane transporter that is expressed mainly in skeletal muscle where it plays an important role in energy expenditure and fat oxidation. In this study, we investigated the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on UCP3 gene expression in C2C12 muscle cells. EPA and DHA up-regulated UCP3 mRNA level in a dose-dependent manner and similarly increased UCP3 promoter activity in C2C12 muscle cells. To determine whether AMP-activated protein kinase (AMPK) signaling may also directly regulate UCP3 expression, 5′-amino-4-imidazolecarboxamide-ribonucleoside (AICAR), an AMP analog that activates AMPK, was treated in C2C12 muscle cells. AICAR showed additive effects with EPA or DHA on the UCP3 promoter activation. These results indicate that EPA and DHA directly regulate the gene expression of UCP3, potentially through AMPK-mediated pathway in C2C12 muscle cells.
Abstract: : Purpose: In a placebo-controlled trial to elevate blood-DHA levels in patients with XLRP, the goal was to assess the potential benefit of supplementation in altering disease progression. However, DHA (22:6w3) is a highly unsaturated long-chain fatty acid and is considered a target molecule for free-radical oxidative damage. Thus, nutritional provision of DHA in a treatment protocol for XLRP may be contra-indicated. Here, non-ocular adverse events as well as antioxidant and blood lipid profiles were assessed at the conclusion of a 4-year supplementation trial. Methods: Patients (n=44) were enrolled in a randomized, double-blind, clinical trial and provided either DHA (400mg/day) or a corn/soy oil placebo. Blood samples were collected every six months for the duration of the trial. Biological safety analysis included blood lipid fatty acid determination, plasma vitamin A & E levels, platelet aggregation, and plasma antioxidant capacity. Results: DHA supplementation elevated blood lipid ...
TY - JOUR. T1 - Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates. AU - Atwell, Kerryn. AU - Collins, Carmel. AU - Sullivan, Thomas. AU - Ryan, Philip. AU - Gibson, Robert. AU - Makrides, Maria. AU - McPhee, Andrew. PY - 2013/1. Y1 - 2013/1. N2 - Aim: To determine the effect of neonatal docosahexaenoic acid (DHA) supplementation in preterm infants on later respiratory-related hospitalisations. Methods We enrolled 657 infants in a multicentre, randomised, controlled trial designed to study the long-term efficacy of higher dose dietary DHA in infants born ,33 weeks gestation. Treatment was with high DHA (∼1%) compared with standard DHA (∼0.3%) in breast milk or formula, given from the first week of life to term equivalent. Parent-reported hospital admissions to 18 months corrected age were recorded. The proportion of children hospitalised for lower respiratory tract (LRT) conditions and the mean number of hospitalisations per infant were ...
Platinum 100% Omega Fish Oil delivers ultra-pure fish oils, which are an excellent source of the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Fish oils help speed up recovery time, burn body fat and promote muscle growth.. Platinum 100% Omega Fish Oil is designed for everyone, from active men and women and fitness enthusiasts to high-performance athletes, powerlifters, crossfitters, bodybuilders, endurance athletes and anyone looking to boost their daily fish oil intake to support general good health.. ...
TY - JOUR. T1 - Is the omega-3 index a valid marker of intestinal membrane phospholipid EPA+DHA content?. AU - Gurzell, Eric A.. AU - Wiesinger, Jason A.. AU - Morkam, Christina. AU - Hemmrich, Sophia. AU - Harris, William. AU - Fenton, Jenifer I.. PY - 2014. Y1 - 2014. N2 - Despite numerous studies investigating n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation and inflammatory bowel diseases (IBD), the extent to which dietary n-3 LCPUFAs incorporate in gastrointestinal (GI) tissues and correlate with red blood cell (RBC) n-3 LCPUFA content is unknown. In this study, mice were fed three diets with increasing percent of energy (%en) derived from eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA). Dietary levels reflected recommended intakes of fish/fish oil by the American Heart Association. We analyzed the FA composition of phospholipids extracted from RBCs, plasma, and GI tissues. We observed that the 0.1%en EPA+DHA diet was sufficient to significantly increase the omega-3 ...
Results Blood DHA increased in children supplemented with DHA (0.65%, 95% CI 0.30% to 1.10% for the DHA 250 mg group and 1.15%, 0.87% to 1.43% for the DHA 500 mg group). The odds of more severe versus less severe liver steatosis after treatment was lower in children treated with DHA 250 mg/day (OR = 0.01, 0.002 to 0.11, p ,0.001) and DHA 500 mg/day (OR = 0.04, 0.002 to 0.46, p = 0.01) as compared to placebo but there was no difference between the DHA groups (p = 0.4). Insulin sensitivity index increased and triglycerides decreased to a similar degree in both DHA groups as compared to placebo but there was no effect on alanine transaminase and body mass index.. ...
Changing dietary fatty acid composition in modern diet influences the prevalence of obesity. Increasing evidences suggest favorable effects of n-3 PUFA for protecting against obesity and the metabolic syndrome. However, the regulation of n-3 PUFA in adipose is still unclear. Thus, this study addressed metabolism of different dietary fats in the adipose tissue of porcine model. Eight-week-old cross-bred pigs were randomly assigned to three groups and fed a 2% fat diet for 30 days from either soybean oil (SBO), docosahexaenoic acid (DHA) or beef tallow. An in vitro experiment was conducted in which linoleic acid (LA), DHA or oleic acid (OA) were added to represent the major fatty acid in the SBO-, DHA- or BT- diets, respectively. Adipocytes size and lipid metabolism related genes were analyzed. Plasma triacylglycerol (TAG) was lower in DHA- than in BT-fed pigs, and the product of lipolysis, glycerol was highest in BT-fed pigs. In addition, expression of the lipolytic genes, adipose triglyceride lipase and
RISHON supply vegetarian Algae docosahexaenoic acid powder, also known as Algal Docosahexaenoic acid Powder, is a free flowing fine powder manufactured by the microencapsulation technology. Algae Docosahexaenoic acid Powder is made fromRead More…. ...
Facebook Dr. Anil Home page AutismItsGutStupid Wall Street Journal Best Seller Dr. Ms Seven-X Plan for Digestive Health Polyunsaturated fatty acids like arachidonic acid (ARA) and docosahexaenoic acid (DHA) are believed to play a critical role in growth and development of brain including the signal messaging system in the brain. Docosahexaenoic Acid supplementation is frequently used to treat kids with autism. Dr. Voigt and colleagues recently conducted a randomized placebo controlled trial in 48 kids. Half of them received 200 mg DHA every day while the rest received placebo. Clinical Global Impressions-Improvement (CGI-I) scales was used. At the end of 6 months, although the DHA group showed a 431% increase in DHA levels, the investigators found that DHA did not have beneficial impact on core behavior of autistic kids as compared to those on placebo. However, Voigt and colleagues conceded that the negative results may have been as a result...
Read Docosahexaenoic acid (DHA) enhances the therapeutic potential of neonatal neural stem cell transplantation post-Traumatic brain injury, Behavioural Brain Research on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
ABSTRACTResolution of inflammation in the periphery was once thought to be a passive process, but new research now suggests it is an active process mediated by specialized pro-resolving lipid mediators (SPM) derived from omega-3 polyunsaturated fatty acids (n-3 PUFA). However, this has yet to be ill
The omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are considered essential because they cant be produced by your body. They must be taken in through diet. A study published in Neurology, the medical journal of the American Academy of Neurology, suggests that a diet lacking omega-3s might lead to faster brain aging, potentially…
Dietary balance of long-chain fatty acids may influence processes involving leukocyte-endothelial interactions, such as atherogenesis and inflammation, that involve increased endothelial expression of leukocyte adhesion molecules, or endothelial activation. We compared the ability of various saturated, monounsaturated, and polyunsaturated fatty acids to modulate endothelial activation. Consumption of the n-3 fatty acid docosahexaenoic acid (DHA; 22:6n-3) reduced endothelial expression of vascular cell adhesion molecule 1 (VCAM-1), E-selectin, intercellular adhesion molecule 1 (ICAM-1), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4, tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration (IC(50)) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations. The magnitude of this effect paralleled its incorporation into cellular phospholipids. DHA also reduced the adhesion of human monocytes and monocytic U937 cells to ...
Neuroscience. 2009 Mar 3;159(1):296-307. doi: 10.1016/j.neuroscience.2008.12.006. Epub 2008 Dec 14. Research Support, Non-U.S. Govt
Fu YQ, Zheng JS, Yang B, Li D. Effect of individual omega-3 fatty acids on the risk of prostate cancer: a systematic review and dose-response meta-analysis of prospective cohort studies. Am J Clin Nutr 1995;62:761-8. 1990;40(6):700-704. What precautions should you take while using Docosahexaenoic Acid? View abstract. Developmental & Reproductive Toxicity . Lopez-Alarcon, M., Furuya-Meguro, M. M., Garcia-Zuniga, P. A., and Tadeo-Pulido, I. Development of visual acuity in relation to plasma and erythrocyte omega-6 and omega-3 fatty acids in healthy term gestation infants. Here are 12 science-backed health benefits of DHA. However, some research shows that taking DHA might improve memory of events and visual and spatial learning in people with age-related mental decline. Lauritzen L, Hoppe C, Straarup EM, Michaelsen KF. Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, sperm, testicles and retina.It can be ...
J:234197 Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR, Silver DL, Mfsd2a Is a Transporter for the Essential omega-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. J Biol Chem. 2016 May 13;291(20):10501-14 ...
A study was recently conducted to determine the effect of supplementing the diet of dairy cows with several levels of an algal product high in the long chain fatty acid docosahexaenoic acid (DHA).
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject-specific sections.
Aim: The purpose of this study was to investigate the influence of docosahexaenoic acid (DHA) on muscle damage and inflammation following an acute eccentric exercise bout. Methods: A double-blind placebo-controlled, study was performed using 41 healthy, untrained males aged 18-28 y who consumed either 2 g/d DHA or placebo (PL, corn oil) for 32 days. Supplements were consumed for 28 days prior to exercise. Participants completed an eccentric exercise procedure of the elbow flexors at 140% of 1-RM (6 sets x 10 repetitions). The time under tension (TUT) for each set of eccentric contractions was recorded manually from the investigators voice commands. Fasted blood samples for prostaglandin E2 (PGE2), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL1-ra), C-reactive protein and creatine kinase (CK) were assessed on days 1, 2 and 4. Fasted serum DHA was measured at baseline (day -28) and on day 1. Peak isometric strength of the elbow flexors, delayed-onset muscle soreness, and range of ...
It has been recommended that pregnant females increase their dietary docosahexaenoic acid (DHA) intakes. These Australian researchers examined whether increasing DHA intake during pregnancy affects depression and enhances their children s subsequent neurodevelopment. They performed a double- blind, multicenter, randomized controlled trial (DHA to Optimize Mother Infant Outcome {DOMInO} trial) in 5 Australian hospitals, enrolling 2399 women with singleton pregnancies at less than 21 weeks gestation. Docosahexaenoic acid-rich fish oil capsules (containing 800 mg/d of DHA) or matched vegetable oil capsules (no DHA) were administered until birth ...
Polyunsaturated phospholipids are known to be important with regard to the biological functions of essential fatty acids, for example, involving neural tissues such as the brain and retina. Here we have employed two complementary structural methods for the study of polyunsaturated bilayer lipids, viz. deuterium ((2)H) NMR spectroscopy and molecular dynamics (MD) computer simulations. Our research constitutes one of the first applications of all-atom MD simulations to polyunsaturated lipids containing docosahexaenoic acid (DHA; 22:6 cis-Delta(4,7,10,13,16,19)). Structural features of the highly unsaturated, mixed-chain phospholipid, 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine (PDPC), have been studied in the liquid-crystalline (L(alpha)) state and compared to the less unsaturated homolog, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). The (2)H NMR spectra of polyunsaturated bilayers are dramatically different from those of less unsaturated phospholipid bilayers. We show ...
Yang B, Fritsche KL, Beversdorf DQ, Gu Z, Lee JC, Folk WR, Greenlief CM, Sun GY. (2019). Yin-Yang Mechanisms Regulating Lipid Peroxidation of Docosahexaenoic Acid and Arachidonic Acid in the Central Nervous System. Front Neurol. 10:642. doi: 10.3389/fneur.2019.00642. eCollection 2019. Review. [PubMed]. Yang B, Li R, Woo T, Browning JD Jr, Song H, Gu Z, Cui J, Lee JC, Fritsche KL, Beversdorf DQ, Sun GY, Greenlief CM. (2019). Maternal Dietary Docosahexaenoic Acid Alters Lipid Peroxidation Products and (n-3)/(n-6) Fatty Acid Balance in Offspring Mice. Metabolites. 9(3). doi: 10.3390/metabo9030040. [PubMed]. Sun GY, Li R, Yang B, Fritsche KL, Beversdorf DQ, Lubahn DB, Geng X, Lee JC, Greenlief CM. (2019). Quercetin Potentiates Docosahexaenoic Acid to Suppress Lipopolysaccharide-induced Oxidative/Inflammatory Responses, Alter Lipid Peroxidation Products, and Enhance the Adaptive Stress Pathways in BV-2 Microglial Cells. Int J Mol Sci. 20(4). doi: 10.3390/ijms20040932. [PubMed]. Teng T, Ridgley DM, ...
Supplementation With Highly Purified Docosahexaenoic Acid Ethyl Ester Was Associated With Enhancement of Hepatic Fatty Acid Oxidation and Greater Apparent Absorption of Docosahexaenoic Acid in Rats
Organelle remodeling processes are evolutionarily conserved and involved in cell functions during development, aging, and cell death. Some endogenous and exogenous molecules can modulate these processes. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has mainly been considered as a modulator of plasma membrane fluidity in brain development and aging, while DHAs role in organelle remodeling in specific neural cell types at the ultrastructural level remains largely unexplored. DHA is notably incorporated into dynamic organelles named lipid bodies (LBs). We hypothesized that DHA could attenuate the inflammatory response in lipopolysaccharide (LPS)-activated microglia by remodeling LBs and altering their functional interplay with mitochondria and other associated organelles. We used electron microscopy to analyze at high spatial resolution organelle changes in N9 microglial cells exposed to the proinflammogen LPS, with or without DHA supplementation. Our results revealed that DHA
DHA has been tested in clinical trials by itself and as part of other food-supplement formulations.. In 2000, Karolinska University Hospital began the OmegAD trial, which evaluated a six-month course of treatment with a DHA-containing fish oil formulation called EPAX 1050 TG in 204 people with mild to moderate AD, of whom 174 completed the study. The treatment and placebo groups did not differ on either of the main outcome measures, decline on the MMSE and ADAS-cog, or on neuropsychiatric symptoms overall. However, analysis of a small subgroup of the 32 mildest cases did suggest less decline on the MMSE, though not ADAS-cog, and a similar slowing of decline appeared to occur in the placebo group once switched to DHA after six months (Freund-Levi et al., 2006; see news and commentary; Freund-Levi et al., 2008). Substudies suggested that DHA treatment increased CSF levels of DHA and other fatty acids and decreased levels of tau, as well as changing expression of inflammation-related genes and ...
Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid that is particularly abundant in the brain and retina. DHA is associated with supporting brain health. Lower levels of DHA have been associated with smaller hippocampal volumes, accumulation of amyloid plaques, and overall lower cognitive function.. DHA is largely derived from marine sources, and it has been correlated with a lower risk of dementia and Alzheimers disease (AD) in a dose-response meta-analysis that aggregated 21 studies with more than 180,000 participants. DHA may also provide protective effects on dopaminergic neurons, and it may be associated with a lower risk of Parkinsons disease. DHA is often paired in supplementation and research with eicosapentaenoic acid (EPA), another omega-3 fatty acid. Both DHA and EPA have been shown to promote synaptic plasticity and the inhibition of synaptic loss, and to support anti-oxidation processes.. The brain-supportive effects of DHA may be dose-dependent. A randomized ...
Dha Docosahexaenoic Acid list and information including what is Dha Docosahexaenoic Acid, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
Dha Docosahexaenoic Acid list and information including what is Dha Docosahexaenoic Acid, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
Docosahexaenoic acid (DHA) and arachidonic acid (ARA) are major components of the cerebral cortex and visual system, where they play a critical role in neural development. We quantitatively mapped fatty acids in 26 regions of the four-week-old breastfed baboon CNS, and studied the influence of dietary DHA and ARA supplementation and prematurity on CNS DHA and ARA concentrations. Baboons were randomized into a breastfed (B) and four formula-fed groups: term, no DHA/ARA (T-); term, DHA/ARA supplemented (T+); preterm, no DHA/ARA (P-); preterm and DHA/ARA supplemented (P+). At four weeks adjusted age, brains were dissected and total fatty acids analyzed by gas chromatography and mass spectrometry. DHA and ARA are rich in many more structures than previously reported. They are most concentrated in structures local to the brain stem and diencephalon, particularly the basal ganglia, limbic regions, thalamus and midbrain, and comparatively lower in white matter. Dietary supplementation increased DHA in all
Novel DHA-enriched oils with high α-linolenic acid (ALA) content will be available in the near future as an alternative for dietary fish oil replacement in aquafeeds. As preliminary validation, we 1) assessed the ability of a diet containing a formulated oil blend (tuna oil + flaxseed oil, TOFX) with high DHA and ALA content to achieve fish oil-like omega-3 long-chain (≥C20) polyunsaturated fatty acids (n-3 LC-PUFA) tissue composition in Atlantic salmon smolts, and 2) applied liver proteomics as exploratory approach to understand the consequent nutritional changes. Comparisons were made on fish fed a fish oil-based diet (FO) and a commercial-like oil blend diet (fish oil + poultry oil, FOPO) over 89 days. Growth and feed efficiency ratio were lower on the TOFX diet. Fish tissue concentration of n-3 LC-PUFA and the n-3:n-6 ratio were significantly higher for TOFX than for FOPO, but not higher than for FO, while tissue retention efficiency of n-3 LC-PUFA was promoted by TOFX relative to FO. Proteomics
Animals given both the DHA infusion and the DHA-enriched diet recovered motor function faster than those given just the DHA infusion. However, the difference in scores did not reach statistical significance, possibly because of the variability in scores and the relatively small differences between the two DHA-treated groups. The investigators noted that in spite of the lack of significant differences, animals given both the DHA-rich diet and the DHA infusion fared better than the DHA-infused animals. Providing DHA only in the diet without the infusion did not improve the animals recovery.. In addition to the benefits of DHA on functional recovery, the investigators reported that DHA infusion plus the DHA-enriched diet was associated with fewer nerve cells lost and less damage to the nerve cell axons. The investigators noted that provision of DHA immediately following the injury was essential for protecting the nerve cells and for functional improvement. A DHA-enriched diet alone was ...
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Welcome to Fats of Life. This is a hub for health on the benefits of EPA and DHA omega-3s intended only for medical practitioners.. If you are a patient researching omega-3s please visit our consumer website alwaysomega3s.com. ...
Docosahexanoic acid + folic acid + methylcobalamin is used in the treatment of .get complete information about docosahexanoic acid + folic acid + methylcobalamin including usage, side effects, drug interaction, expert advice along with medicines associated with docosahexanoic acid + folic acid + methylcobalamin at 1mg.com
DHA-clozapine List of omega-3 fatty acids Polyunsaturated fatty acids Guesnet P, Alessandri JM (2011). "Docosahexaenoic acid ( ... 19-hexa-enoic acid, and its shorthand name is 22:6(n−3) in the nomenclature of fatty acids. Most of the docosahexaenoic acid in ... Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex ... 2007). "Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients ...
3 fatty acids involved in human physiology are α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid ( ... Omega−3 fatty acids, also called Omega-3 oils, ω−3 fatty acids or n−3 fatty acids, are polyunsaturated fatty acids (PUFAs) ... α-linolenic acid (18:3, n-3; ALA), eicosapentaenoic acid (20:5, n-3; EPA), and docosahexaenoic acid (22:6, n-3; DHA). These ... 3 fatty acid medicines containing a combination of an ethyl ester of eicosapentaenoic acid and docosahexaenoic acid at a dose ...
Fish are high in vitamin D. Fish also contain docosahexaenoic acid (DHA), which help with a variety of neurological ... Horrocks LA, Yeo YK (September 1999). "Health benefits of docosahexaenoic acid (DHA)". Pharmacological Research. 40 (3): 211-25 ... 5-HTP (an amino acid that helps to produce serotonin, and is often used to help those with depression) has also been suggested ...
There is docosahexaenoic acid along with saxitoxin. Lilly, E. L.; Halanych, K. M.; Anderson, D. M. (2007). "Species boundaries ...
... docosapentaenoic acid → 9,12,15,18,21-tetracosapentaenoic acid → 6,9,12,15,18,21-tetracosahexaenoic aciddocosahexaenoic acid ... fatty acid. It is an isomer of gamma-linolenic acid (GLA), an 18:3 (n−6) fatty acid (i.e., a polyunsaturated omega-6 fatty acid ... For the acid C18H32O2 I suggest the name "linolic acid"; for the acid C18H30O2 [I suggest] the name "linolenic acid".) ... Eicosapentaenoic acid (EPA; 20:5, n−3) and docosahexaenoic acid (DHA; 22:6, n−3) are readily available from fish and algae oil ...
... docosahexaenoic acid or DHA (22:6n-3) ω-6 fatty acids: gamma-linolenic acid or GLA (18:3n-6) dihomo-gamma-linolenic acid or ... examples include docosahexaenoic acid (an omega-3 fatty acid) and gamma-linolenic acid (an omega-6 fatty acid). Whitney Ellie; ... ω-3 fatty acid: α-linolenic acid or ALA (18:3n-3) ω-6 fatty acid: linoleic acid or LA (18:2n-6) These two fatty acids cannot be ... Only two fatty acids are known to be essential for humans: alpha-linolenic acid (an omega-3 fatty acid) and linoleic acid (an ...
Heinemann, K.M.; Bauer, J.E. (2006). "Docosahexaenoic acid and neurologic development in animals". Journal of the American ... and retinal functions in healthy puppies fed foods fortified with docosahexaenoic acid-rich fish oil from 8 to 52 weeks of age ... DHA is the main n-3 fatty acid and can be obtained as DHA itself from dietary sources such as fish and fish oils, or as the DHA ... Adequate intake and recommended allowance levels of 85g/kg (DM) of total fat (8.5%), and 0.5g/kg (DM) of omega 3 fatty acids ( ...
... docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), which are essential fatty acids for the growth and reproduction of ... docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) which are essential for marine crustaceans. Their main ... Soybean Oil Enhanced with Conjugated Linoleic Acids, Menhaden Fish Oil, or an Algal Docosahexaenoic Acid Supplement on Channel ... "Optimization of Docosahexaenoic Acid (DHA) Production and Improvement of Astaxanthin Content in a Mutant Schizochytrium ...
13-epoxides isomers termed coronaric acids or isoleukotoxins. They metabolize the omega-3 fatty acid, docosahexaenoic acid, ... dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular ... see 20-Hydroxyeicosatetraenoic acid), i.e. 19-hydroxyhydroxyeicosatetraenoic acid and/or 20-hydroxyeicosatetranoic acid, take ... They metabolize the omega-6 fatty acids arachidonic acid, which possess four double bonds, to 8 different epoxide isomers which ...
... are metabolites of the 22-carbon straight-chain omega-3 fatty acid, docosahexaenoic acid (DHA). Cell types that express certain ... see 20-Hydroxyeicosatetraenoic acid), i.e. 19-hydroxyeicosatetraenoic acid and/or 20-hydroxyeicosatetranoic acid, take on ... Epoxide docosapentaenoic acids (epoxydocosapentaenoic acids, EDPs, or EpDPEs) ... "Metabolism of eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450". Archives of Biochemistry and ...
... eicosapentaenoic acid and docosahexaenoic acid. The distinction between the omega-6 and omega-3 fatty acid substrates is ... Adrenic acid or 7(Z),10(Z),13(Z),16(Z)-docosatetraenoic acid, an abundant fatty acid in the adrenal gland, kidney, vasculature ... However, the CYP epoxygenases also metabolize other omega-6 fatty acids such as linoleic acid and the omega-3 fatty acids, ... see epoxyeicosatetraenoic acid). 4(Z),7(Z),10(Z),13(Z),16(Z),19(Z)-docosahexaenoic acid (DHA) is metabolized by the same CYP ...
... is one of the most abundant fatty acids in the brain, and is present in similar quantities to docosahexaenoic ... Arachidonic acid is also a precursor to anandamide. Some arachidonic acid is converted into hydroxyeicosatetraenoic acids ( ... it is uncertain if humans can in fact convert linoleic acid to arachidonic acid. Since little or no arachidonic acid is found ... Arachidonic acid is not one of the essential fatty acids. However, it does become essential if a deficiency in linoleic acid ...
RvD's are metabolites of the 22-carbon ω-3 fatty acid docosahexaenoic acid; see Specialized pro-resolving mediators#DHA-derived ... Eicosapentaenoic acid (EPA), i.e.i.e. 5Z, 8Z,11Z,14Z,17Z-eicosapentaenoic acid is an ω-3 fatty acid with five cis double bonds ... Mead acid, i.e. 5Z,8Z,11Z-eicosatrienoic acid, is an ω-9 fatty acid containing three cis double bonds, each located between ... Dihomo-gamma-linolenic acid (DGLA), 8Z, 11Z,14Z-eicosatrienoic acid is an ω-6 fatty acid with three cis double bonds, each ...
Sakayori, Nobuyuki; Osumi, Noriko (2017). "The role of docosahexaenoic acid in brain development". Vitamins. The Vitamin ... OSUMI, Noriko (2011). "Polyunsaturated Fatty Acids and Fatty Acid Binding Protein Involvements in Neurogenesis". Oleoscience. ... Osumi, Noriko (2016). "Functional analysis of fatty acid signals in brain development". Reports of Research Assisted by the ... Sakayori, Nobuyuki; Osumi, Noriko (2018). "The role of essential fatty acids in brain development". Journal of Lipid Nutrition ...
... especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This characteristic is therefore widely used to feed ... Eicosapentaenoic and Docosahexaenoic Acids". Journal of Agricultural and Food Chemistry. 51 (8): 2237-41. doi:10.1021/jf025952y ... D.lutheri is capable of producing a large amount of polyunsaturated fatty acids, ...
It likewise metabolizes docosahexaenoic acid to epoxydocosapentaenoic acids (EDPs; primarily 19,20-epoxy-eicosapentaenoic acid ... vernolic acid (also termed leukotoxin) and coronaric acid (also termed isoleukotoxin); these linoleic acid epoxides cause ... see 20-Hydroxyeicosatetraenoic acid, epoxyeicosatetraenoic acid, and epoxydocosapentaenoic acid sections on activities and ... In particular, CYP2C9 metabolizes arachidonic acid to the following eicosatrienoic acid epoxide (EETs) stereoisomer sets: 5R,6S ...
nov.: psychrophilic Antarctic species with the ability to synthesize docosahexaenoic acid (22: 63)". International Journal of ...
... acids are derived from fish oil and are a purified mixture of the polyunsaturated free fatty acids docosahexaenoic acid (DHA) ... It appears that both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) lower triglycerides. However, DHA appears to ... Omega-3 carboxylic acids, like other omega-3 fatty acid based drugs, appears to reduce production of triglycerides in the liver ... In addition, as with other omega-3 fatty acids, taking omega-3 carboxylic acids puts people who are on anticoagulants at risk ...
"Effects of eicosapentaenoic acid and docosahexaenoic acid versus α-linolenic acid supplementation on cardiometabolic risk ... Vazhappilly R, Chen F (1998). "Eicosapentaenoic acid and docosahexaenoic acid production potential of microalgae and their ... AbuMweis, S; Jew, S; Tayyem, R; Agraib, L (February 2018). "Eicosapentaenoic acid and docosahexaenoic acid containing ... Eicosapentaenoic acid (EPA; also icosapentaenoic acid) is an omega-3 fatty acid. In physiological literature, it is given the ...
MRI evidence that docosahexaenoic acid DHA ethyl ester improves myelination in generalized peroxisomal disorders. Demyelination ... Martinez, Manuela; Vazquez, Elida (1 July 1998). "MRI evidence that docosahexaenoic acid ethyl ester improves myelination in ...
... is a psychrophilic Antarctic bacterial species with the ability to synthesize docosahexaenoic acid. It is ... nov.: psychrophilic Antarctic species with the ability to synthesize docosahexaenoic acid (22: 63)". International Journal of ...
2007). "Neurofurans: Novel indices of oxidant stress derived from docosahexaenoic acid". J Biol Chem. 283 (1): 6-16. doi: ... Neurofurans are 22-carbon compounds formed nonenzymatically by free radical mediated peroxidation of docosahexaenoic acid (DHA ... an ω-3 essential fatty acid. The neurofurans are similar to the isofurans and are formed under similar conditions of oxidative ...
C. cohnii can acclimate a higher docosahexaenoic acid to polyunsaturated fatty acids ratio, however current studies are trying ... Jiang, Y; Chen, F (1999-12-01). "Effects of salinity on cell growth and docosahexaenoic acid content of the heterotrophic ... It is used industrially in the production of docosahexaenoic acid. Crypthecodinium cohnii is a heterotrophic non-photosynthetic ... Jiang, Yue; Chen, Feng; Liang, Shi-Zhong (September 1999). "Production potential of docosahexaenoic acid by the heterotrophic ...
SPM are metabolites of arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or n-3 DPA (i.e. 7,10Z, ... 19Z-docosahexaenoic acid and 8-cysteinylglycinyl,7,17-dihydroxy-4Z,9,11,13Z,15E,19Z-docosahexaenoic acid) have been shown to be ... 19Z-docosahexaenoic acid and 16-cysteinylglycinyl,17-hydroxy-4Z,7Z,10,12,14,19Z-docosahexaenoic acid) form in vitro, accelerate ... 16Z-docosapentaenoic acid or osbond acid) is an isomer of n-3 DPA (clupanodonic acid) differing form the latter fatty acid only ...
Kim, Hee-Yong (2007-06-29). "Novel metabolism of docosahexaenoic acid in neural cells". Journal of Biological Chemistry. 282 ( ... Akbar, Mohammed; Calderon, Frances; Wen, Zhiming; Kim, Hee-Yong (2005-08-02). "Docosahexaenoic acid: a positive modulator of ... "Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3): Role of phosphatidylserine in antiapoptotic effect". ... "Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid". Prostaglandins, Leukotrienes and ...
In addition, scientists argue that the Homo species was also able to obtain nutrients like docosahexaenoic acid from algae that ... Bradbury, Joanne (10 May 2011). "Docosahexaenoic Acid (DHA): An Ancient Nutrient for the Modern Human Brain". Nutrients. 3 (5 ... The site has been dated through radiocarbon dating to between 110,000 BP and 61,000 BP through amino-acid racemization. Fire ...
Certain species produce large amounts of docosahexaenoic acid (DHA) and are grown commercially for production of this oil for ... "Expressed sequence tag analysis of marine fungus Schizochytrium producing docosahexaenoic acid". Journal of Biotechnology. 138 ... Yue Jiang; King-Wai Fan; Raymond Tsz-Yeung Wong & Feng Chen (2004). "Fatty acid composition and squalene content of the marine ... DHA synthesis in Schizochytrium does not involve membrane-bound desaturases or fatty acid elongation enzymes such as those ...
... docosahexaenoic acid (DHA, i.e. 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid), b) α-Linolenic acid (ALA, i.e. 9Z,12Z,15Z- ... 19Z-docosahexaenoic acid (10R,17S-diHDHA); 8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid (8S,15S-diHETE); 9S,16S-10E,12Z ... 10S,17S-Dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid. This compound is the 13Z cis-trans isomer of 10-epi-protectin D ( ... A maresin termed MaR isomer or 7-epi-MaR1, i.e. 7S,14S-dihydroxy-4Z,8E,10Z,12E,16Z,19Z-docosahexaenoic acid (see specialized ...
"Pharmacokinetics and Oxidation Parameters in Volunteers Supplemented with Microencapsulated Docosahexaenoic Acid". ... al Acids and acid esters Torularhodin 3',4'-Didehydro-β,γ-caroten-16'-oic acid Torularhodin methyl ester Methyl 3',4'-didehydro ... carotenedioic acid Crocetinsemialdehyde 8'-Oxo-8,8'-diapo-8-carotenoic acid Crocin Digentiobiosyl 8,8'-diapo-8,8'- ... Plants are known to use two different pathways for IPP production: the cytosolic mevalonic acid pathway (MVA) and the plastidic ...
Morita, Eiko; Kumon, Yasuyuki; Nakahara, Toro; Kagiwada, Satoshi; Noguchi, Tetsuko (2006). "Docosahexaenoic Acid Production and ... culture of the microalgae Schizochytrium limacinum on biodiesel-derived crude glycerol for producing docosahexaenoic acid". ...
... finding that PUFA like arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid all occurred at significantly lower ... De Vriese, S. R.; Christophe, A. B.; Maes, M. (2004). "In humans, the seasonal variation in poly-unsaturated fatty acids is ... Another study focused on the association between depression, suicide, and the amount of polyunsaturated fatty acids (PUFA). ... They state that "depression is accompanied by a depletion of n-3 poly-unsaturated fatty acids". Their methodology involved ...
Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients. J Ren Nutr, 17(5), 296-304, 2007 Ikizler ... Recombinant human growth hormone improves muscle amino acid uptake and whole-body protein metabolism in chronic hemodialysis ... Does hemodialysis increase protein breakdown? Dissociation between whole-body amino acid turnover and regional muscle kinetics ...
... composition for this application because of its high content of polyunsaturated fatty acids such as docosahexaenoic acid (DHA ... stearidonic acid and alpha-linolenic acid. T. lutea contain betain lipids and phospholipids. Bendif, El Mahdi; Probert, Ian; ... total lipid content and fatty acid composition of recently isolated tropical microalgae Isochrysis sp., Nitzschia closterium, ...
"Docosahexaenoic acid-derived fatty acid esters of hydroxy fatty acids (FAHFAs) with anti-inflammatory properties". Diabetes. 65 ... Docosahexaenoic acid ester of hydroxy-linoleic acid (DHAHLA) exert anti-inflammatory and pro-resolving properties. ... Palmitic acid esters of hydroxy-stearic acids (PAHSAs) are among the most bioactive members able to activate G-protein coupled ... fatty acid esters of hydroxy fatty acids) are formed in adipose tissue, improve glucose tolerance and also reduce adipose ...
The taste of powdered euglena is described as dried sardine flakes, and contains minerals, vitamins and docosahexaenoic, an ... Nucleic Acids Research. 33 (9): 2781-91. doi:10.1093/nar/gki574. PMC 1126904. PMID 15894796. Margulis, Lynn (2007). "Power to ... omega-3 acid. The powder is used as ingredient in other foods. Kemin Industries sells a euglena nutraceutical supplement ...
... gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid when presented not only as free acids ... By metabolizing the ω-3 polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, into 17-HpDHA, 17-HDHA, ... By metabolizing ω-3 polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, into lipoxins and resolvins, ... 19Z-docosahexaenoic acid (17S-HpDHA) and 17S-hydroxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid (17S-HDHA). One or both of ...
The most notable fatty acids found in human breast milk are docosahexaenoic acid and arachidonic acid, which have been shown to ... Gynoid fat is mainly composed of long-chain polyunsaturated fatty acids. It is proposed that babies which are breast-fed are ... This is because it contains long-chain polyunsaturated fatty acids (PUFAs), which are important in the development of fetuses. ... "Long-chain polyunsaturated fatty acids in human milk". Acta Paediatrica. 88 (430): 68-71. doi:10.1111/j.1651-2227.1999.tb01303. ...
... is a very long chain polyunsaturated omega-3 fatty acid, similar to docosahexaenoic acid (DHA). The lipid name is ... It is not well studied, but polyunsaturated fatty acids even longer than DHA, nisinic acid included, may hold scientific ... and other methylene-interrupted very long chain polyunsaturated fatty acids". In Paige L. Gilmore (ed.). Lipids: Categories, ... Fatty acids, All stub articles, Organic compound stubs). ... promise.[vague] Vyssotski, M. (2011). "Nisinic acid, 24: 6n-3, ...
Omega-3-acid ethyl esters are a mixture of ethyl eicosapentaenoic acid and ethyl docosahexaenoic acid, which are ethyl esters ... of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in fish oil. Together with dietary ... After ingestion, omega-3-acid ethyl esters are metabolized mostly in the liver like other dietary fatty acids. Omega-3-acid ... eicosapentaenoic acid ethyl ester (460 mg) and docosahexaenoic acid ethyl ester (380 mg). Pronova BioPharma ASA had its roots ...
... are docosanoid metabolites of the omega 3 fatty acid, docosahexaenoic acid (DHA) while resolvins of the E series (RvD1, RvD2, ... are eicosanoid metabolites of the omega 3 fatty acid, eicosapentaenoic acid (EPA). These metabolites, which are made by the ... Aoyama K, Matsumura N, Watabe M, Wang F, Kikuchi-Utsumi K, Nakaki T (2011). "Caffeine and uric acid mediate glutathione ... Fish oil: This contains n-3 polyunsaturated fatty acids that are known to offset oxidative stress and mitochondrial dysfunction ...
Mallick, Rahul; Basak, Sanjay; Duttaroy, Asim K. (2019-12-01). "Docosahexaenoic acid, 22:6n‐3: Its roles in the structure and ... Basak, Sanjay; Mallick, Rahul; Duttaroy, Asim K. (2020-11-25). "Maternal Docosahexaenoic Acid Status during Pregnancy and Its ... "Maternal Supply of Both Arachidonic and Docosahexaenoic Acids Is Required for Optimal Neurodevelopment". Nutrients. 13 (6): ... Another area of his research has been the investigation of the fatty acid transport system in human placenta and its roles in ...
... as products of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid, the EDP and EEQ metabolites contribute ... see 20-Hydroxyeicosatetraenoic acid) but also has epoxygenase activity in that it metabolizes docosahexaenoic acid to epoxides ... see 20-Hydroxyeicosatetraenoic acid). The EDP (see Epoxydocosapentaenoic acid) and EEQ (see epoxyeicosatetraenoic acid) ... Jaiswal AK, Nebert DW, Gonzalez FJ (Aug 1986). "Human P3(450): cDNA and complete amino acid sequence". Nucleic Acids Research. ...
... compounds and polyunsaturated fatty acids affect progeny performance and levels of selenium and docosahexaenoic acid in the ... G.N Schrauzer, who has written two papers about selenomethionine, claims it should be an essential amino acid, and that the ... Total selenium in selenium yeast can be reliably determined using open acid digestion to extract selenium from the yeast matrix ... In some products, the added selenium is structurally substituted for sulfur in the amino acid methionine, thus forming an ...
Seal oil is a source of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Dried fish is ... "Associations of very high intakes of eicosapentaenoic and docosahexaenoic acids with biomarkers of chronic disease risk among ... Alaska subsistence communities are noted to obtain up to 97% of the omega-3 fatty acids through a subsistence diet. The ...
Docosahexaenoic acid, a 22:6 omega-3 fatty acid Dehydroandrosterone, an endogenous androgenic steroid Dehydroascorbic acid, an ... oxidized form of ascorbic acid Dehydroacetic acid, a pyrone derivative used as a plasticiser, as a fungicide, as a bactericide ... an uncommon unsaturated α-amino acid Defence Housing Australia, a provider of family housing for members of the Australian ...
Salmon is a fish with high fat content and smoked salmon is a good source of omega-3 fatty acids including docosahexaenoic acid ... Cooking low-acid food items in a retortable pouch is a relatively new process, with the first commercial use of such retort ... DHA) and eicosapentaenoic acid (EPA). Smoked salmon has a high sodium content due to the salt added during brining and curing. ... heat processing of all other smoked salmon products yet still maintains its quality as a good source of omega-3 fatty acids. ...
... eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Alpha-linoleic acid is an essential fatty acid, and is the form ... Other amino acids such as cysteine, arginine, histidine, and aspartic acid have been known to decrease in availability due to ... L-Carnitine is an amino acid that plays a key role in energy production, and facilitates the transport of fatty acids into the ... Omega-3 fatty acids are polyunsaturated fatty acids (PUFAs) that are essential for proper brain and cognitive development. They ...
... of the Q/R site can effect inhibition of the channel by membrane fatty acids such as arachidonic acid and docosahexaenoic acid ... "Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids". J. Gen. Physiol. 132 (1): 85- ... Editing results in a change in amino acid in the second membrane domain of the receptor. The editing site is found within the ... For Kainate receptors with only edited isforms, these are strongly inhibited by these fatty acids. However, inclusion of just ...
T. anax produces many different bioactive compounds such as arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. ... and have anti-inflammatory properties Specifically arachidonic acid promotes blood clotting and wound healing. This is why many ...
... docosa-hexaenoic acid (a shortening of dyoicosa-hexanoic) e.g. (e)icositetragon e.g. eicosapenta-enoic acid e.g. ...
... docosahexaenoic acid) or C20:4 ω-6 (arachidonic acid), (both are polyunsaturated acids). Plasmalogens are classified according ... They treated these tissue sections with acid or mercuric chloride as part of a method to stain the nucleus. This resulted in ... In turn, the latter reacted with a fuchsine-sulfurous acid stain used in this nuclear staining method and gave rise to colored ... During inflammation, neutrophil-derived myeloperoxidase produces Hypochlorous acid, which causes oxidative chlorination of ...
"Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor ... "Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid". Nature. 509 (7501): 503-506. Bibcode: ... MFSD2a has been shown to transport LPC-bound polyunsaturated fatty acids, including DHA and EPA, across the blood-brain and ... Lysophosphatidylcholines are produced within cells mainly by the enzyme phospholipase A2, which removes one of the fatty acid ...
The polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic acid, DHA, and eicosapentaenoic acid ... An important function is the production and control of bile acids. Too much bile acid can be toxic to cells and its synthesis ... A change in the plasma pH gives an acid-base imbalance. In acid-base homeostasis there are two mechanisms that can help ... It is only the lactate and the waste products of the citric acid cycle that are returned to the blood. The liver can take up ...
... including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). They are present in amounts comparable to Atlantic salmon ... People who suffer from gout or high uric acid in the blood should avoid eating such foods. Most importantly, sprats contain ... The sprats contain about 1.43 g/100 g of these polyunsaturated fatty acids that have been found to help prevent mental, neural ... "Content of essential polyunsaturated fatty acids in three canned fish species." International Journal of Food Sciences & ...
McCann, JC; Ames, BN (2005). "Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development ... Burr, George O.; Burr, Mildred M. (1930-04-01). "On The Nature And Rôle Of The Fatty Acids Essential In Nutrition". The Journal ... Stoll, A.L.; Locke, C.A.; Marangell, L.B.; Severus, W.E. (1999). "Omega-3 fatty acids and bipolar disorder: A review". ... Ruderman, Neil B.; Toews, CJ; Shafrir, E (1969). "Role of Free Fatty Acids in Glucose Homeostasis". Archives of Internal ...
DHA is an essential fatty acid (FA) since it, or its short chain precursor, alpha-linolenic acid (LnA, 18:3 n-3), have to be ... is the major polyunsaturated fatty acid (PUFA) in the adult mammalian brain. ... Docosahexaenoic acid (DHA, 22:6 n-3) is the major polyunsaturated fatty acid (PUFA) in the adult mammalian brain. DHA is an ... Mechanisms of docosahexaenoic acid accretion in the fetal brain J Neurosci Res. 1998 Apr 15;52(2):129-36. doi: 10.1002/(SICI) ...
... an essential fatty acid, or lipid) that has many effects in the body, including the development of the eyes and brain. ... Docosahexaenoic acid, or DHA, is a nutritional compound ( ... Docosahexaenoic acid levels play an important role in infant ... Docosahexaenoic acid, or "DHA," is a nutritional compound (an essential fatty acid, or lipid) that has many effects in the body ... We suggest that future research attempt to produce changes in maternal DHA by supplementing with the fatty acid during ...
This publication focuses on the production of docosahexaenoic acid (DHA; 22:6), an ω-3 polyunsaturated fatty acid with ... described in this book was to identify relevant process parameters for the large-scale production of docosahexaenoic acid (DHA ... Other polyunsaturated fatty acids represent less than 1% of the C. cohnii-derived oil. The aim of the research ...
A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model. ... the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of ... fatty acids, are crucial components of the diet. Docosahexanoic acid (DHA) is an n-3 polyunsaturated fatty acid (PUFA) found ... Fatty acid analysis also revealed compensatory increases in another C22 fatty acid, docosapentanoic acid (DPAn-6), a phenomenon ...
Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active ... acids. Conference Paper * Direct quantitation of omega-3 fatty acid intake of Canadian residents of a long-term care facility ... Effect of a Novel Omega-3 and Omega-6 Fatty Acid Supplement on Dry Eye Disease: A 3-month Randomized Controlled Trial Academic ... Effect of n-3 fatty acids from fish oil on hemostasis, blood pressure, and lipid profile of dialysis patients Academic Article ...
Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an ... N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, ... Many of these compounds belong to the fatty acid amides, conjugates of fatty acids with biogenic amines. Conjugates of DHA with ... may be an additional member of the group of immune-modulating n-3 fatty acid-derived lipid mediators. ...
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that falls into the larger category of polyunsaturated fatty acids (PUFAs ... research shows omega-3 fatty acids, including DHA, are essential in the prevention and treatment of numerous diseases. DHA has ... Although many chronic conditions are associated with excessive intake of dietary saturated and trans fatty acids (including ...
High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-β and tau ... N-3 fatty acids reduced trans fatty acids retention and increased docosahexaenoic acid levels in the brain. *J. Lavandera, J. ... A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model. *G. ... Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving ...
... Salmo salar) in seawater; effects on performance, tissue fatty acid composition, and fillet quality. ...
A Meta-Analysis Shows That Docosahexaenoic Acid from Algal Oil Reduces Serum Triglycerides and Increases HDL-Cholesterol and ... "A Meta-Analysis Shows That Docosahexaenoic Acid from Algal Oil Reduces Serum Triglycerides and Increases HDL-Cholesterol and ... Certain algae contain the (n-3) fatty acid DHA, yet the relation between algal oil supplementation and cardiovascular disease ... fatty acids not extracted from fish, may reduce serum TG and increase HDL-C and LDL-C in persons without coronary heart disease ...
19-Docosahexaenoic Acid-[21,21,22,22,22-d5] Methyl Ester Home / Products / Fatty Acids / cis-4,7,10,13,16,19-Docosahexaenoic ... cis-4,7,10,13,16,19-Docosahexaenoic Acid-[21,21,22,22,22-d5] Methyl Ester. Deuterium Size. ... 19-Docosahexaenoic Acid View Details * Preview Catalog: 9036 CAS: 1197205-71-2 cis-4,7,10,13,16,19-Docosahexaenoic Acid-[21,21, ...
All you need to know about Docosahexaenoic acid, its properties and its uses in skin care and cosmetics ... Docosahexaenoic acid. DOCOSAHEXANOIC ACID. INCI: Docosahexaenoic acid. What is Docosahexaenoic acid?. Docosahexaenoic acid is ... Docosahexaenoic acid is similar to other PUFA, is very important for skin point of view. Any skin related issues especially ... Docosahexaenoic acid is found in capsules, serum and in some lotions and creams. ...
Treatment with the ω-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) exerts ... N2 - Treatment with the ω-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) ... AB - Treatment with the ω-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) ... abstract = "Treatment with the ω-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid ( ...
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid. ... Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid. ... triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid. Clin Sci (Lond). 2021 01 15; 135(1):19-34. ...
... long-chain polyunsaturated fatty acid (LCPUFA) relevant for brain function. It has largely been explored as a potential ... DHA docosahexaenoic acid, DiHDoHE 10S,17S-dihydroxy-docosa-4Z,7Z,11E,13Z,15E,19Z-hexaenoic acid, ERK extracellular-regulated ... From: Role of docosahexaenoic acid in the modulation of glial cells in Alzheimers disease ... Docosahexaenoic acid (DHA) is an omega-3 (ω-3) ...
... fibrosis in rats. ... Fish oil containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has been reported to exert beneficial health ... Substances : DHA (Docosahexaenoic Acid) : CK(1117) : AC(204). Diseases : Chemically-Induced Liver Damage : CK(1565) : AC(721), ... Docosahexaenoic acid attenuates carbon tetrachloride-induced hepatic fibrosis in rats. - GreenMedInfo Summary ...
T1 - High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri (Tanzania) ... 2005). High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri ( ... High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri (Tanzania): ... High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri (Tanzania): ...
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Brain Supplements Docosahexaenoic Acid. What You Need To Know. An honest article about Nootropics and how they work. Read it ... Brain Supplements Docosahexaenoic Acid. What are the Brain Supplements Docosahexaenoic Acid. The human brain has lots of ... Brain Supplements Docosahexaenoic Acid. The very best cognitive enhancers (smart drugs) offer a natural assistance to what you ... Brain Supplements Docosahexaenoic Acid. With the improvement of science and research, all age groups can optimize their ...
... we investigated the therapeutic role of docosahexaenoic acid (DHA), a single n-3 PUFA, in lung fibrosis. Intratracheal DHA or ... Since n-3 polyunsaturated fatty acids (n-3 PUFAs) may beneficially modulate immune responses in a variety of inflammatory ... These results suggest that further investigations regarding the role of n-3 polyunsaturated fatty acids in fibrotic lung injury ... As n-3 polyunsaturated fatty acids, such as DHA (docosahexaenoic acid), have the capacity to modulate immune responses with ...
Preliminary evidence suggests that docosahexaenoic acid (DHA), an omega-3 fatty acid, has been found to inhibit cancer cell ... Nutritional supplementations, such as omega-3 (n-3) polyunsaturated fatty acids (PUFAs), have been known to lower the chances ...
N2 - This paper presents the positional distribution of fatty acids in docosahexaenoic acid (22:6n-3)-rich fish oil triacyl-sn- ... AB - This paper presents the positional distribution of fatty acids in docosahexaenoic acid (22:6n-3)-rich fish oil triacyl-sn- ... This paper presents the positional distribution of fatty acids in docosahexaenoic acid (22:6n-3)-rich fish oil triacyl-sn- ... keywords = "Bonito, docosahexaenoic acid, fatty acid, fish oil, positional distribution, sardine, seal, stereospecific analysis ...
A Rabbit polyclonal antibody against Pan-species Docosahexaenoic Acid (DHA). This antibody is labeled with Cy3. ... Docosahexaenoic Acid (DHA) Polyclonal Antibody (Pan-species), Cy3. Der Lieferant: Cloud-Clone. 0 ... Docosahexaenoic Acid (DHA) Polyclonal Antibody (Pan-species), APC Der Lieferant:Cloud-Clone ... A Rabbit polyclonal antibody against Pan-species Docosahexaenoic Acid (DHA). This antibody is labeled with Cy3. ...
Docosahexaenoic Acid extracts and nutritional supplements have benefits and are used by cancer patients. Beneficial for which ... Tags: can Docosahexaenoic Acid help fight cancer , Docosahexaenoic Acid , Docosahexaenoic Acid benefits , Docosahexaenoic Acid ... Docosahexaenoic Acid cancer , Docosahexaenoic Acid extracts , Docosahexaenoic Acid foods , Docosahexaenoic Acid for cancer ... Docosahexaenoic Acid supplement , Docosahexaenoic Acid supplement side effects , is Docosahexaenoic Acid good for cancer ...
It is a fatty acid called docosahexaenoic acid.. Fear not if its name looks incomprehensible, it is a name invented by organic ... A Long Name, a Long Lipid: Docosahexaenoic Acid Tweet. It is often difficult to get a handle on what molecules are and what ... But humans have a problem; we cannot make this fatty acid. It is nothing to panic about as we can get much of what we need from ... It is given the trivial name cevronic acid. Whatever we choose to call it, there is evidence that without it, several of our ...
Docosahexaenoic acid (DHA22:6n3), the principal n3-polyunsaturated fatty acid (PUFA) in the retina, has been shown to have a ... Docosahexaenoic acid (DHA22:6n3), the principal n3-polyunsaturated fatty acid (PUFA) in the retina, has been shown to have a ... Docosahexaenoic acid (DHA22:6n3), the principal n3-polyunsaturated fatty acid (PUFA) in the retina, has been shown to have a ... Docosahexaenoic acid (DHA22:6n3), the principal n3-polyunsaturated fatty acid (PUFA) in the retina, has been shown to have a ...
T1 - Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm ... Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm ... Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm ... Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm ...
Docosahexaenoic Acid: Properties, Functions and Health Effects UK ed. Edition. June 28, 2018. ...
The present report is a risk assessment of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid ( ... Risk Assessment of "Other Substances" -Eicosapentaenoic Acid, Docosapentaenoic Acid and Docosahexaenoic Acid. en_US. ... Risk Assessment of "Other Substances" -Eicosapentaenoic Acid, Docosapentaenoic Acid and Docosahexaenoic Acid. European Journal ... EPA, DPA and DHA are long chain n-3 polyunsaturated fatty acids (n-3 LCPUFA) and in food these fatty acids are incorporated in ...
Abbreviations: ApoA-I, Apolipoprotein A-I; ApoB, Apolipoprotein B; BMI, body mass index; DHA, docosahexaenoic acid; EGG, Early ... fatty acids and amino acids, producing metabolic clues that prime the liver for NAFLD and increase susceptibility to NASH.[5] ... polyunsaturated fatty acids; SD, standard deviation; SFA, saturated fatty acids; WC, waist circumference; WHR, waist-to-hip ... Omega-3 fatty acids. met-d-Omega_3. 114 999. European. 1-SD. ... Mediator: fatty acids. SFA. met-d-SFA. 114 999. European. 1-SD ...
  • Diradylglycerol formation is altered by n-3 highly unsaturated fatty acids, with differences between eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. (mcmaster.ca)
  • The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters. (mcmaster.ca)
  • Treatment with the ω-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) exerts cardioprotective effects, and suppresses Ca 2+ -induced opening of the mitochondrial permeability transition pore (MPTP). (elsevier.com)
  • Fish oil containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has been reported to exert beneficial health effects, including hepatoprotection. (greenmedinfo.com)
  • The present report is a risk assessment of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) in food supplements, and is based on previous risk assessments and a literature search. (who.int)
  • Omega-3 fatty acids , especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may have beneficial effects on COVID-19. (medicalnewstoday.com)
  • The other is called eicosapentaenoic acid or EPA. (psychologytoday.com)
  • EPA (eicosapentaenoic acid) (min. (anaheimfeed.com)
  • Dietary a-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid were also inversely associated with breast cancer risk, with adjusted ORs (95% confidence intervals) of 0.51 (0.38-0.70), 0.68 (0.55-0.84), 0.68 (0.55-0.85), and 0.76 (0.61-0.94), respectively. (qualitycounts.com)
  • A 6-ounce serving of canned oysters supplies 358 milligrams eicosapentaenoic acid, or EPA, and 388 milligrams of docosahexaenoic acid. (healthfully.com)
  • ALA (alpha-linolenic acid), EPA (eicosapentaenoic acid), and DHA (docosahexaenoic acid). (masalamonk.com)
  • Marine oils contain Omega-3 fatty acids that include docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). (toptrendz.net)
  • Omega-3 is made up of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DPA). (hypogalblog.com)
  • a rich source of Omega-3, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). (226ers.com)
  • The best known are alpha-linolenic acid (ALA) and the fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). (floridahealthnews.com)
  • Omega-3 contains three fatty acids, EPA Eicosapentaenoic Acid, ALA Alpha-lipoic acid and DHA Docosahexaenoic Acid. (siraj.co)
  • In contrast, Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found in marine animals and fatty fish. (awebfind.biz)
  • Like salmon, tuna is an excellent source of omega-3 fatty acids, in the form of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA). (foodfornet.com)
  • Omega 3 is an essential Fatty Acid sourced from Fish Oil, which is rich in EPA (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid). (fitmuscleonline.com)
  • The researchers used a technique called gas chromatography to measure the concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in red blood cells. (najjarcafe.com)
  • Fish oil is composed of two important omega-3 fatty acids called docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and are used during the development of a fetus's nervous system. (premom.com)
  • Krill oil is rich in the long-chain omega-3s eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and more than 80 percent of these two fatty acids are bound to phospholipids, predominantly phosphatidylcholine. (uschinahpa.org)
  • These effects are associated with increased DHA and EPA, and lower arachidonic acid (ARA) in cardiac phospholipids. (elsevier.com)
  • High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri (Tanzania): targets for infant formulae close to our ancient diet? (rug.nl)
  • Current recommendations for arachidonic (AA) and docosahexaenoic (DHA) acids in infant formulae are based on milk of Western mothers. (rug.nl)
  • It is believed that the beneficial effects of n-3 PUFAs are due in part to the replacement of arachidonic acid in the membrane phospholipids of inflammatory cells with the n-3 PUFAs thus leading to a reduced capacity of immune cells to synthesize LTs and PGs [ 36 , 37 ]. (biomedcentral.com)
  • This omega-3-fatty-acid-rich diet led to reduced arachidonic acid levels in the blood, enhanced macrophage recruitment, and increased the production of the DHA-derived SPM Resolvin D1 (RvD1) in the lung following HDE exposure. (cdc.gov)
  • Docosahexaenoic acid (DHA) and arachidonic acid (ARA) long chain polyunsaturated fatty acids (LCPUFAs) play a central role in the development and function of the brain, eyes and immune system during infancy. (dsm.com)
  • Should Arachidonic acid (ARA) be added to infant formulas when Docosahexaenoic acid (DHA) is added? (dsm.com)
  • What causes cellular inflammation is an increase in the omega-6 fatty acid known as arachidonic acid (AA). (psychologytoday.com)
  • Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. (bvsalud.org)
  • Certain algae contain the (n-3) fatty acid DHA, yet the relation between algal oil supplementation and cardiovascular disease risk factors has not been systematically examined. (harvard.edu)
  • We compared the effects of dietary supplementation with the ω-3 PUFAs DHA and EPA on cardiac mitochondrial phospholipid fatty acid composition and Ca 2+ -induced MPTP opening. (elsevier.com)
  • In summary, dietary supplementation with DHA but not EPA, profoundly altered mitochondrial phospholipid fatty acid composition and delayed Ca 2+ -induced MPTP opening. (elsevier.com)
  • Humans have a limited capacity to synthesise EPA, DPA and subsequently DHA from the precursor alpha-linolenic acid (ALA), and this endogenous production is negligible in comparison to the doses used in supplementation studies. (who.int)
  • 1995). Regular consumption of or supplementation with omega-3 polyunsaturated fatty acids can have beneficial effects on long-term cardiovascular health due to anti-inflammatory and possibly antiarrhythmic effects (Kang, et al. (cdc.gov)
  • In order to test whether hyperlipidaemia and glycaemic control can be improved among diabetes patients by dietary supplementation with purified omega-3 fatty acids, we carried out a double-blind, placebo-controlled trial on 50 type 2 diabetes patients randomized to 2 g/day purified omega-3 fatty acids or placebo for 10 weeks. (who.int)
  • There are three commonly available natural sources of Omega-3 fatty acid supplementation that are used for mental health: krill oil, n-3 docosahexaenoic acid (DHA) and a few types of fish oils. (socalsendy.com)
  • Although many chronic conditions are associated with excessive intake of dietary saturated and trans fatty acids (including obesity, insulin resistance, coronary heart disease, and some forms of cancer), research shows omega-3 fatty acids, including DHA, are essential in the prevention and treatment of numerous diseases. (altmedrev.com)
  • Dietary sources are fatty fish, cod liver-, seal-, whale-, fish- and krill oils and human milk, containing various ratios of these fatty acids in combination. (who.int)
  • 1998). The dietary content of saturated, monounsaturated, and polyunsaturated fatty acids influence the concentration of cholesterol in low-density and high-density lipoproteins, and consequently the development of atherosclerosis (O'Keefe, et al. (cdc.gov)
  • Over the past few decades, the cardiovascular benefits of a high dietary intake of long-chain polyunsaturated fatty acids (PUFAs), like docosahexaenoic acid (DHA), have been extensively studied. (repositoriosaludmadrid.es)
  • Association of dietary intake of n-3 polyunsaturated fatty acids with breast cancer risk in pre- and postmenopausal Chinese women - Menopause 2022 Jul 26 - 'Higher intake of marine n-3 PUFAs and total n-3 PUFAs was associated with lower risk of breast cancer, with adjusted OR quartile 4 v.1 (95% confidence intervals) of 0.68 (0.55-0.84) and 0.56 (0.42-0.75), respectively. (qualitycounts.com)
  • These omega-3 fatty acids might lower your risk for heart disease when you average a total combined intake of at least 250 milligrams per day, according to the 2010 Dietary Guidelines from the U.S. Department of Health and Human Services. (healthfully.com)
  • As humans are incapable of synthesising Omega 3, it is essential that we consume them via dietary sources.There are several types of Omega 3 fatty acids. (fitmuscleonline.com)
  • 1998). Long-chain polyunsaturated fatty acids are essential for normal development (Hamosh, et al. (cdc.gov)
  • DHA is an essential fatty acid (FA) since it, or its short chain precursor, alpha-linolenic acid (LnA, 18:3 n-3), have to be obtained in the diet. (nih.gov)
  • It can be synthesized from alpha-linolenic acid. (lesielle.com)
  • the most common one is Alpha-linolenic acid (ALA). ALA is mostly found in plant foods such as nuts, oils, and leafy vegetables. (awebfind.biz)
  • Docosahexaenoic acid, or "DHA," is a nutritional compound (an essential fatty acid, or lipid) that has many effects in the body, including the development of the eyes and brain. (news-medical.net)
  • Taken together, our data suggest that DHDA, a potentially endogenous endocannabinoid, may be an additional member of the group of immune-modulating n-3 fatty acid-derived lipid mediators. (wur.nl)
  • Conclusion: The oral administration of docosahexaenoic acid to pregnant mice during pregnancy can induce dipalmitoyl phosphatidylcholine production and secretion, which is the major lipid component of surfactant. (utmb.edu)
  • Docosahexaenoic acid (DHA) lessens adipose tissue lipid deposition partly by inducing adipocyte apoptosis in grass carp , but the underlying mechanism remains unclear. (bvsalud.org)
  • Omega-3 fatty acids had no significant effect on serum lipid levels, ApoA-I, glucose, insulin and HbA1c. (who.int)
  • In fact, the intake of both phospholipids and omega-3 fatty acids has been shown to influence the lipid composition in the skin, favorably shifting the balance between water loss and water content in the skin ( Vet Res Commun , 2011.35(8):501-9). (uschinahpa.org)
  • [ 5 ] In addition, there are impairments in amino acid metabolism associated with insulin resistance, as well as alterations in fatty acids and intact lipids, which are partially because of altered de novo liver lipogenesis, lipolysis rate and very low-density lipoprotein metabolism in NAFLD. (medscape.com)
  • Fish oil, a complex mixture of polyunsaturated fatty acids as well as a range of other unsaturated and saturated fatty acids, has been deemed beneficial in a wide variety of human chronic ailments [ 11 - 16 ]. (biomedcentral.com)
  • The takeaway being - cancer, genomics, treatments and other personalized factors will influence decision making to questions like: Are extracts or nutritional supplements Docosahexaenoic Acid beneficial and should not be taken? (addon.life)
  • There is strong evidence that omega-3 fatty acids have a beneficial effect in bipolar disorder. (greenmedinfo.com)
  • A comprehensive wellness supplement such as Platinum Performance® Canine that provides omega-3 fatty acids, antioxidants, vitamins and minerals can be very beneficial to make sure dogs receive all the essential nutrients they require to stay healthy as they age. (platinumperformance.com)
  • Omega-3 fatty acids are so beneficial to the development of strong, healthy eyes that many baby formula companies add it to their formula (6). (hypogalblog.com)
  • Docosahexaenoic acid is a beneficial replacement treatment for spinocerebellar ataxia 38. (cdc.gov)
  • The analysis of individual plasma or serum fatty acids is important in the recognition of essential fatty acid deficiency (Siguel E. 1998) and in the differential diagnosis of inborn errors of metabolism, such as mitochondrial fatty acid oxidation disorders (Costa, et al. (cdc.gov)
  • Universal Nutrition Animal Omega contains a well-balanced and ultra-concentrated essential fatty acid (EFA) blend consisting of omega-3's and 6's that your body not only needs, but requires in order to build lean muscle mass and maintain overall health. (allstarhealth.com)
  • Use Animal Omega as you would your regular essential fatty acid (EFA) supplement. (allstarhealth.com)
  • The #1-selling omega-3 in the U.S. ♦ , Ultimate Omega offers concentrated levels of omega-3s for high-intensity essential fatty acid support. (organicbasicfood.com)
  • ALA is an essential fatty acid. (floridahealthnews.com)
  • But, why is omega-3 considered an essential fatty acid? (findyourhealthyplace.com)
  • Epidemiological studies suggest that increased intake of the omega-3 (n-3) polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of Alzheimer's disease (AD). (jneurosci.org)
  • Public health recommendations advise increasing or decreasing the intake of various classes of fatty acids (saturated, monounsaturated, polyunsaturated) but relatively little fatty acid biomarker data exist to support these recommendations and reference range data are scarce. (cdc.gov)
  • Nutritional intake of omega-3 fatty acids may affect the rate of decline of visual acuity (see Diet), although further clinical trials must be done to determine DHA benefit. (medscape.com)
  • An Ohio study on the effect of Omega-3 on cytokine production in the brain yielded a surprising side effect of the intake of Omega-3 fatty acids by a group of medical students. (hypogalblog.com)
  • A regular intake of Omega-3 fatty acids strengthen the cell membranes, which in turn boosts the performance of Serotonin which prevents anxiety (5). (hypogalblog.com)
  • While battling infertility is a complicated and often expensive process, one thing that you can do to help is to increase your daily intake of Omega-3 fatty acids. (hypogalblog.com)
  • This is supported by research on supplements with fish fatty acids, which shows that an intake of 1 gram per day of EPA and DHA reduces the risk of mortality from heart disease by about 10% in people with (a high risk of) cardiovascular disease. (floridahealthnews.com)
  • Grab some Oregon's Wild Harvest Evening Primrose Oil to get your daily intake of omega-6 fatty acids or Barlean's Seriously Delicious Total Omega Orange Creme when you want to add all three omega 3-6-9 fatty acids to your wellness regimen. (findyourhealthyplace.com)
  • According to a new study, increasing the intake of omega-3 fatty acids helps maintain brain health and improve cognition in middle age. (najjarcafe.com)
  • For people with the Alzheimer's disease-associated APOE4 gene, omega-3 fatty acid intake was associated with greater hippocampal volume and less small vessel disease. (najjarcafe.com)
  • Docosahexaenoic acid is found in capsules, serum and in some lotions and creams. (lesielle.com)
  • 2001), total fatty acids are hexane-extracted from the matrix (100uL serum or plasma) along with an internal standard solution containing eighteen stable isotopically-labeled fatty acids to account for recovery. (cdc.gov)
  • Fetal and neonatal serum concentrations of docosahexaenoic acid (DHA) are 150 μM, or ≃ 50-fold higher than in the adult. (elsevier.com)
  • abstract = "Objective: Our purpose was to determine whether docosahexaenoic acid increased surfactant production, as reflected by increased dipalmitoyl phosphatidylcholine, in mouse fetal lung and amniotic fluid. (utmb.edu)
  • abstract = "This is a review of randomized controlled trials using docosahexaenoic acid (DHA) interventions in the first 1000 days of life with assessments of behavioral functioning in childhood. (sahmri.org.au)
  • Docosahexaenoic acid (DHA) is an omega-3 fatty acid that falls into the larger category of polyunsaturated fatty acids (PUFAs). (altmedrev.com)
  • Since n-3 polyunsaturated fatty acids (n-3 PUFAs) may beneficially modulate immune responses in a variety of inflammatory disorders, we investigated the therapeutic role of docosahexaenoic acid (DHA), a single n-3 PUFA, in lung fibrosis. (biomedcentral.com)
  • Nutritional supplementations, such as omega-3 (n-3) polyunsaturated fatty acids (PUFAs), have been known to lower the chances of developing cancer, especially in breast cancer. (unr.edu)
  • Human milk fatty acid relationships from our historical worldwide database and the literature revealed that disparities between the Doromoni diet and the presumed ancient diet (i.e. higher carbohydrate and linoleic acid intakes) are unlikely to affect milk AA and DHA contents. (rug.nl)
  • This includes alpha-linoleic acid, or ALA, the plant-based version of omega-3 fatty acids. (foodfornet.com)
  • Most of the fats in chia seeds are healthy fats, such as alpha-linoleic acid . (foodfornet.com)
  • Navy beans, soybeans, and kidney beans are good vegetable sources of omega-3 fatty acid, alpha-linoleic acid. (foodfornet.com)
  • thus, we must consume foods rich in omega-3 fatty acids. (masalamonk.com)
  • Chia seeds are packed with minerals and vitamins, and they're rich in omega-3 fatty acids. (foodfornet.com)
  • Beans are known for being rich in both fiber and protein, but they're surprisingly rich in omega-3 fatty acids, too. (foodfornet.com)
  • But what happens when the levels of omega-3 fatty acids are low in the brain? (psychologytoday.com)
  • Flaxseed is what's used to feed all those chickens that are laying eggs with higher levels of omega-3 fatty acids. (sozailink.com)
  • Low plasma concentrations of docosahexaenoic acid (DHA) are reported in unsupplemented cystic fibrosis (CF) patients. (unime.it)
  • The team looked at the relationship between omega-3 fatty acid concentrations in red blood cells, MRI, and cognitive markers of brain aging. (najjarcafe.com)
  • Docosahexaenoic acid (DHA, 22:6 n-3) is the major polyunsaturated fatty acid (PUFA) in the adult mammalian brain. (nih.gov)
  • Docosahexanoic acid (DHA) is an n-3 polyunsaturated fatty acid (PUFA) found predominantly in marine fish and algae. (jneurosci.org)
  • Docosahexaenoic acid is an omega-3 fatty acid or long-chain PUFA (polyunsaturated fatty acid) found in fish oils. (lesielle.com)
  • Docosahexaenoic acid is similar to other PUFA, is very important for skin point of view. (lesielle.com)
  • Thus, investigating a single, pure polyunsaturated fatty acid (PUFA) is pivotal in understanding its role in diseases. (biomedcentral.com)
  • Docosahexaenoic acid (DHA 22:6n3 ), the principal n3-polyunsaturated fatty acid (PUFA) in the retina, has been shown to have a pronounced anti-inflammatory effect in numerous in vivo and in vitro studies. (elsevier.com)
  • Folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B 12 is deficient. (nih.gov)
  • Folic acid in doses above 1.0 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations progress. (nih.gov)
  • Allergic sensitization has been reported following both oral and parenteral administration of folic acid. (nih.gov)
  • During pregnancy, iron is a woman's best friend, and the liver is fully loaded with these key nutrients such as folic acid [ 4 ]. (carnivorestyle.com)
  • When the mother eats healthily according to the Disc of Five, the child gets enough omega-3 fatty acids during pregnancy and breastfeeding. (floridahealthnews.com)
  • Babies born prematurely don't produce enough omega-3 fatty acids themselves. (floridahealthnews.com)
  • Then make sure you're consuming enough omega-3 fatty acids to help you do just that. (findyourhealthyplace.com)
  • The reality is, most US adults don't get enough omega-3 fatty acids through their diet. (findyourhealthyplace.com)
  • Your joints will thank you for consuming enough omega-3 fatty acids! (findyourhealthyplace.com)
  • It is a fatty acid called docosahexaenoic acid. (samuelfurse.com)
  • Omega-3 fatty acids may help alleviate depression but only when a particular type of fatty acid called DHA is used in the right ratio with another fatty acid known as EPA, a new study suggests. (yourfibrodoctor.com)
  • EPA, DPA and DHA are long chain n-3 polyunsaturated fatty acids (n-3 LCPUFA) and in food these fatty acids are incorporated in triacylglycerols (TAGs) and phospholipids (PLs). (who.int)
  • Esterified fatty acids are hydrolyzed primarily from triglycerides, phospholipids and cholesteryl esters using sequential treatment with mineral acid and base in the presence of heat. (cdc.gov)
  • Nutritional supplements and extracts like Docosahexaenoic Acid have benefits and are used by cancer patients and those at-genetic risk of cancer. (addon.life)
  • Taking Docosahexaenoic Acid extracts or nutritional supplements may benefit Primary Penile Squamous Cell Carcinoma patients on Cisplatin treatment over Lemon Peel nutritional supplements. (addon.life)
  • Similarly, taking nutritional supplements Docosahexaenoic Acid may benefit healthy individuals who are at genetic risk of cancer due to mutation of gene CDH1 over Perilla. (addon.life)
  • But avoid nutritional supplements Docosahexaenoic Acid when at genetic risk of cancer due to mutation of gene FGFR2. (addon.life)
  • Under the agreement, DSM Nutritional Products becomes Lonza's supplier for its Schizochytrium-based DHA (docosahexaenoic acid) omega-3 oil. (nutraingredients.com)
  • B5 (pantothenic acid) is known to help fight acne, so it's not smart to hinder your ability to absorb and utilize it. (draxe.com)
  • Image analysis of brain sections with an antibody against Aβ (amino acids 1-13) revealed that overall plaque burden was significantly reduced by 40.3%, with the largest reductions (40-50%) in the hippocampus and parietal cortex. (jneurosci.org)
  • Fatty acid composition of food, plasma, and brain tissues was determined. (frontiersin.org)
  • So when the brain becomes inflamed, its only protection is adequate levels of anti-inflammatory omega-3 fatty acids. (psychologytoday.com)
  • There are two omega-3 fatty acids in the brain. (psychologytoday.com)
  • This is the primary anti-inflammatory omega-3 fatty acid for the brain. (psychologytoday.com)
  • It is also the most abundant omega-3 fatty acid found in tissues, especially the brain and retina. (energyfirst.com)
  • Long-chain omega-3 fatty acids are crucial for the eye and brain development of the fetus. (masalamonk.com)
  • These acids play an important role in brain functioning and eliminate the risk of cardiovascular disease. (toptrendz.net)
  • Eating fish and the fish fatty acid docosahexaenoic acid (DHA) during pregnancy and breastfeeding is important for the development of the brain and retina of the child. (floridahealthnews.com)
  • If you're one of the 90%, taking a supplement like Solgar Omega-3 Fish Oil Concentrate is a great way to ensure you consume an optimal amount of these essential fatty acids each day to support your heart, brain, and more. (findyourhealthyplace.com)
  • Consuming cold-water fish and other sources of omega-3 fatty acids may preserve brain health and improve cognition in middle age, new evidence shows. (najjarcafe.com)
  • The new contribution here is that even at a younger age, if you have a diet that includes omega-3 fatty acids, you are already protecting your brain for most of the indicators of brain aging that we see in middle age" , said Claudia. (najjarcafe.com)
  • Omega-3 fatty acids such as EPA and DHA are key micronutrients that enhance and protect the brain," said study co-author Debora Melo van Lent, PhD, postdoctoral researcher at the Biggs Institute. (najjarcafe.com)
  • Omega-3 Fatty Acids Omega-3 fatty acids (EPA and DHA) are required for proper brain development and development of the nervous system and are essential for normal brain signaling, best sarms in uk. (socalsendy.com)
  • Omega-3 fatty acids, amino acids and antioxidants can help support the health of your senior dog. (platinumperformance.com)
  • Omega-3 fatty acids, antioxidants, vitamins and minerals provided in Platinum Performance® Canine CJ complement any canine diet and work synergistically to supply aging cells with the support needed to repair, maintain and thrive. (platinumperformance.com)
  • Many experts agree that vitamins (A, B, C and E), minerals (chromium, copper and zinc), herbs/botanicals, fatty acids and antioxidants are key ingredients to achieving great skin health. (uschinahpa.org)
  • Plasma Amino Acid Abnormalities in Chronic Heart Failure. (mdpi.com)
  • Phenylalanine is a well-known amino acid. (nfsmi.org)
  • Hemp seeds contain a good amount of arginine, a vital amino acid for the healthy heart of mom and baby. (masalamonk.com)
  • Glutamine is the most abundant Amino Acid within muscle tissue, however when you train, Glutamine levels can be significantly reduced as muscle tissue breaks down - even more so with the bodybuilding style of training. (fitmuscleonline.com)
  • This amino-acid-like molecule is a critical component of the complex transporting system that brings fat into the mitochondria, where it is finally burned away for good. (bodybuildingfocus.com)
  • High quality protein made with wild caught salmon and zero grains, designed for all life stages, optimal amino acid. (petdogexpert.com)
  • This study demonstrates FABP5 deficiency and impaired DHA transport at the BBB are associated with increased vulnerability to cognitive deficits in mice fed an n‐3 fatty acid‐depleted diet, in line with previous studies demonstrating a crucial role of FABp5 in BBB transport of DHA and cognitive function. (semanticscholar.org)
  • Veterinarians recommend DHA (docosahexaenoic acid) to support a healthy skin and coat, cognitive function and cardiovascular health. (platinumperformance.com)
  • Effects of a normolipidic diet containing trans fatty acids during perinatal period on the growth, hippocampus fatty acid profile, and memory of young rats according to sex. (semanticscholar.org)
  • The endoplasmic reticulum stress and B cell lymphoma-2 related ovarian killer participate in docosahexaenoic acid-induced adipocyte apoptosis in grass carp (Ctenopharyngodon idellus). (bvsalud.org)
  • However, the ER stress inhibitor, 4-phenylbutyric acid (4-PBA), effectively suppressed DHA-induced apoptosis (P adipocyte apoptosis . (bvsalud.org)
  • This study showed that docosahexaenoic acid (DHA) induces apoptosis in grass carp adipocytes through endoplasmic reticulum (ER) stress and unfolded protein response (UPR). (bvsalud.org)
  • The actual Ω-3 fatty acid docosahexaenoic acid precisely causes apoptosis throughout tumor-derived tissues along with curb tumor increase in stomach cancer. (prbookmarkingwebsites.com)
  • According to information from the NFSA, EPA, DPA and DHA are food supplement ingredients in Norway, and NFSA has requested a risk assessment of these fatty acids in the following doses in food supplements: EPA: 1500, 1750 and 1825 mg/day DPA: 100, 125 and 150 mg/day DHA: 1050 and 1290 mg/day Children below 10 years were not included in the terms of reference. (who.int)
  • C22-unsaturated fatty acids found predominantly in FISH OILS . (bvsalud.org)
  • For Which Cancer Types Should I Avoid Docosahexaenoic Acid (DHA) Supplement? (addon.life)
  • Hence a different and new approach is needed to find out for which cancers you should not take Docosahexaenoic Acid supplement and why should not take them? (addon.life)
  • Chronic effects of omega-3 fatty acids (fish oil) in a rat 5/6 renal ablation model. (mcmaster.ca)
  • This paper presents the positional distribution of fatty acids in docosahexaenoic acid (22:6n-3)-rich fish oil triacyl-sn-glycerols (TG). (elsevier.com)
  • It is emphasised that this risk assessment concerns the single fatty acids EPA, DPA or DHA separately and not mixtures of these as found in e.g. fish oil/cod liver oil. (who.int)
  • Oily fish is a high source of omega-3 fatty acids. (medicalnewstoday.com)
  • Platinum DHA Oil is a very palatable vegetarian-based source of long chain omega-3 fatty acids that can be used in place of fish-based DHA oils. (platinumperformance.com)
  • EPA and DHA are mainly known as fish fatty acids. (floridahealthnews.com)
  • EPA and DHA are known as fish fatty acids but can also be obtained from other foods. (floridahealthnews.com)
  • White (lean) fish also contains fish fatty acids. (floridahealthnews.com)
  • Solgar Omega-3 Fish Oil Concentrate delivers your daily dose of essential fatty acids in a potent, easily-absorbed softgel! (findyourhealthyplace.com)
  • Fish oil contains omega 3 fatty acids, which have a number of health benefits. (foodfornet.com)
  • The best foods for omega 3 fatty acids range from cold-water fish such as salmon and mackerel to vegetables like spinach, broccoli, and okra. (foodfornet.com)
  • Tuna and other fatty fish provide omega-3 fatty acids and protein. (foodfornet.com)
  • During pregnancy, it is strongly advised to consume meat, mainly fish, to obtain the precious long omega-3 fatty acids, such as docosahexaenoic acid (DHA), which are also present in red meat though in smaller quantities. (carnivorestyle.com)
  • Preliminary evidence suggests that docosahexaenoic acid (DHA), an omega-3 fatty acid, has been found to inhibit cancer cell growth and alters the phosphorylation status of Myc. (unr.edu)
  • A high docosahexaenoic acid diet alters the lung inflammatory response to acute dust exposure. (cdc.gov)
  • Docosahexaenoic acid attenuates carbon tetrachloride-induced hepatic fibrosis in rats. (greenmedinfo.com)
  • Evidence in humans and non-human primates suggests that intrauterine growth restriction may lead to persistent changes in insulin sensitivity and hepatic metabolism of glucose, fatty acids and amino acids, producing metabolic clues that prime the liver for NAFLD and increase susceptibility to NASH. (medscape.com)
  • Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study. (ox.ac.uk)
  • Is it okay to take Docosahexaenoic Acid extracts or supplements for all cancer indications and any chemotherapy treatment? (addon.life)
  • But Docosahexaenoic Acid supplements or Docosahexaenoic Acid extracts offer less benefit if on Radiation treatment for Primary Pleomorphic xanthoastrocytoma compared to Cinnamon. (addon.life)
  • Should you take supplements Docosahexaenoic Acid? (addon.life)
  • In one case documented in the Archives of Internal Medicine, the use of Omega-3 fatty acid supplements in patients with anxiety and depression improved symptoms associated with depression by approximately 75% at the 12-week mark, best sarms stack. (socalsendy.com)
  • Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. (wur.nl)
  • Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid. (umassmed.edu)
  • A diet intervention using the omega-3 fatty acid docosahexaenoic acid (DHA) has been shown to be an effective therapeutic approach for alleviating a dust-induced inflammatory response. (cdc.gov)
  • From this fatty acid comes a wide range of inflammatory hormones known as eicosanoids that are the usual suspects when it comes to inflammation. (psychologytoday.com)