C22-unsaturated fatty acids found predominantly in FISH OILS.
A plant genus of the family MELIACEAE. Members contain azadirachtin A (a limonoid commonly referred to as azadirachtin) and other TRITERPENES. They have been used in PESTICIDES. The old name of Melia azadirachta is very similar to a related plant, MELIA AZEDARACH.
A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.
Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Oils high in unsaturated fats extracted from the bodies of fish or fish parts, especially the LIVER. Those from the liver are usually high in VITAMIN A. The oils are used as DIETARY SUPPLEMENTS. They are also used in soaps and detergents and as protective coatings.
FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.
A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
Aquatic invertebrates belonging to the phylum MOLLUSCA or the subphylum CRUSTACEA, and used as food.
Marine fish and shellfish used as food or suitable for food. (Webster, 3d ed) SHELLFISH and FISH PRODUCTS are more specific types of SEAFOOD.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Conversion into nitroso compounds. An example is the reaction of nitrites with amino compounds to form carcinogenic N-nitrosamines.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 1.11.1.9.
Hereditary, progressive degeneration of the neuroepithelium of the retina characterized by night blindness and progressive contraction of the visual field.
A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
Specialized PHOTOTRANSDUCTION neurons in the vertebrates, such as the RETINAL ROD CELLS and the RETINAL CONE CELLS. Non-visual photoreceptor neurons have been reported in the deep brain, the PINEAL GLAND and organs of the circadian system.
Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade.
Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Excision of the uterus.
Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.
A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.
Tumors or cancer of the human BREAST.
The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.
The period before MENOPAUSE. In premenopausal women, the climacteric transition from full sexual maturity to cessation of ovarian cycle takes place between the age of late thirty and early fifty.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Long chain organic acid molecules that must be obtained from the diet. Examples are LINOLEIC ACIDS and LINOLENIC ACIDS.
A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Drinking an excessive amount of ALCOHOLIC BEVERAGES in a short period of time.
A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).
An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
FATTY ACIDS which have the first unsaturated bond in the sixth position from the omega carbon. A typical American diet tends to contain substantially more omega-6 than OMEGA-3 FATTY ACIDS.
A fatty acid that is found in plants and involved in the formation of prostaglandins.
Fish of the genera ONCORHYNCHUS and Salmo in the family SALMONIDAE. They are anadromous game fish, frequenting the coastal waters of both the North Atlantic and Pacific. They are known for their gameness as a sport fish and for the quality of their flesh as a table fish. (Webster, 3d ed).
Food products manufactured from fish (e.g., FISH FLOUR, fish meal).
A publication issued at stated, more or less regular, intervals.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).

Effects of docosahexaenoic and eicosapentaenoic acid on lipid metabolism, eicosanoid production, platelet aggregation and atherosclerosis in hypercholesterolemic rats. (1/1678)

Exogenously hypercholesterolemic (ExHC) rats were fed on an atherogenic diet supplemented with 1% each of either ethyl ester docosahexaenoic acid [EE-DHA, 22:6(n-3)], ethyl ester eicosapentaenoic acid [EE-EPA, 20:5(n-3)] or safflower oil (SO) for 6 months. The rats fed on the diets containing EE-EPA or EE-DHA, compared with those fed on SO, had lower serum cholesterol and triacylglycerol levels, less aggregation of platelets and slower progress of intimal thickening in the ascending aorta. Relative to the SO-fed rats, both of the (n-3) fatty acid-fed rats had a significantly reduced proportion of arachidonic acid in the platelet and aortic phospholipids, and lower production of thromboxane A2 by platelets and of prostacyclin by the aorta. These results suggest that EPA and DHA are similarly involved in preventing atherosclerosis development by reducing hypercholesterolemia and modifying the platelet functions.  (+info)

Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats. (2/1678)

The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.  (+info)

Plasmalogen status influences docosahexaenoic acid levels in a macrophage cell line. Insights using ether lipid-deficient variants. (3/1678)

Previously, this laboratory reported the isolation of variants, RAW. 12 and RAW.108, from the macrophage-like cell line RAW 264.7 that are defective in plasmalogen biosynthesis [Zoeller, R.A. et al. 1992. J. Biol. Chem. 267: 8299-8306]. Fatty acid analysis showed significant changes in the mutants in the ethanolamine phospholipids (PE), the only phospholipid class in which the plasmalogen species, plasmenylethanolamine, contributes significantly. Within the PE fraction, docosapentaenoic (DPA; 22:5n-3) and docosahexaenoic (DHA; 22:6n-3) acids were reduced by approximately 50% in the variants while the levels of arachidonic acid (AA; 20:4n-6) remained unaffected. The decrease in DHA was accompanied by a 50% decrease in labeling PE with [3H]DHA over a 90-min period. Restoration of plasmenylethanolamine by supplementing the growth medium with sn -1-hexadecylglycerol (HG) completely reversed these changes in RAW. 108. Pre-existing pools of plasmenylethanolamine were not required for restoration of normal [3H]DHA labeling; addition of HG only during the labeling period was sufficient. Due to the loss of Delta1'-desaturase in RAW.12, HG supplementation resulted in the accumulation of plasmenylethanolamine's immediate biosynthetic precursor, plasmanylethanolamine. Even though this latter phospholipid contained only the ether functionality (lacking the vinyl ether double bond) it was sufficient to restore wild type-like fatty acid composition and DHA labeling of the ethanolamine phospholipids, identifying the ether bond as a structural determinant for this specificity. In summary, we have used these mutants to establish that the plasmalogen status of a cell can influence the levels of certain polyunsaturated fatty acids. These results support the notion that certain polyunsaturated fatty acids, such as DHA, can be selectively targeted to plasmalogens and that this targeting occurs during de novo biosynthesis, or shortly thereafter, through modification of nascent plasmalogen pools.  (+info)

Fish oil constituent docosahexa-enoic acid selectively inhibits growth of human papillomavirus immortalized keratinocytes. (4/1678)

The omega-3-fatty acids inhibit proliferation of breast cancer cells whereas omega-6-fatty acids stimulate growth. In this study, we examined effects of these fatty acids on human pre-cancerous cells. Cervical keratinocytes, immortalized with the oncogenic human papillomavirus (HPV) type 16, were treated with linoleic acid, an omega-6-fatty acid, and the omega-3-fatty acids, eicosapentaenoic and docosahexaenoic acids. Using both cell counts and bromodeoxyuridine incorporation, docosahexaenoic acid inhibited growth of these cells to a greater extent than eicosapenta-enoic acid. Linoleic acid had no effect. The effect of docosahexaenoic acid was dose dependent and caused growth arrest. Docosahexaenoic acid inhibited growth of HPV16 immortalized foreskin keratinocytes and laryngeal keratinocytes grown from explants of benign tumors caused by papillomavirus, but had no effect on normal foreskin and laryngeal keratinocytes. Docosahexaenoic acid inhibited growth in the presence of estradiol, a growth stimulator for these cells. Indomethacin, a cyclooxygenase inhibitor like docosahexaenoic acid, had only minimal effect on growth. Alpha-tocopherol, a peroxidation inhibitor, abrogated effects of docosahexaenoic acid implying that inhibitory effects were via lipid peroxidation.  (+info)

Effect of prostanoids and their precursors on the aggregation of rainbow trout thrombocytes. (5/1678)

The role of prostanoids and their precursor fatty acids in the aggregatory response of thrombocytes (platelet equivalents of fish) from the rainbow trout, Oncorhynchus mykiss, was studied. Aggregation of these cells was induced by the thromboxane mimetic U-46619 or arachidonic acid (AA) in the presence of human or trout fibrinogen. The production of TXB2/3 by thrombocytes in response to stimulation with AA was inhibited by aspirin, ibuprofen, and indomethacin. However, thrombocyte aggregation in response to AA stimulation was not significantly altered by these agents at the concentrations tested (10-100 microM), with the exception of indomethacin at 20 and 40 microM. Effects on cytosolic calcium concentration have been suggested as an alternative mechanism for the inhibitory action of indomethacin on human platelet aggregation. The present study, however, failed to identify this as a mechanism for the inhibition of U-46619-induced trout thrombocyte aggregation by indomethacin. The polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid both exhibited an inhibitory effect on U-46619-induced thrombocyte aggregation similar to that observed with mammalian platelets. Unlike the case in mammalian hemostasis, prostacyclin inhibited thrombocyte aggregation only at high concentrations (>5 microM). Prostaglandin E2, however, inhibited thrombocyte aggregation at much lower concentrations (>0.01 microM), suggesting that it may be the major inhibitory eicosanoid in trout.  (+info)

Activation of NADPH oxidase by docosahexaenoic acid hydroperoxide and its inhibition by a novel retinal pigment epithelial protein. (6/1678)

PURPOSE: In an earlier study, a novel retinal pigment epithelial protective protein (RPP) was described, which suppresses the superoxide generation of activated polymorphonuclear leukocytes (PMNs). In experimental autoimmune uveitis, docosahexaenoic acid hydroperoxide (22:6OOH) has been shown to be the major lipid peroxidation product in photoreceptors. This hydroperoxide was also found to be chemotactic to PMNs. This study was undertaken to evaluate the activation capability of 22:6OOH in resting PMNs and the possible inhibition of this activation by RPP. METHODS: The 22:6OOH was obtained from pure 22:6 and was purified by thin-layer and high-performance liquid chromatography. Intact rabbit peritoneal PMNs (7-8 X 10(5)) were coincubated with 0.5 microM formyl-methionyl-leucyl-phenylalanine (fMLP), 1.3 microM 22:6OOH, or 5.0 microM 22:6. These systems were coincubated with and without 0.25 microg/ml RPP. From PMN cell-free preparations, the reconstitutes each containing 21 microg plasma membranes and 276 microg cytosolic factors were coincubated with arachidonate, 22:6OOH, or 22:6, each at 100 microM. The inhibition of superoxide production was estimated by adding 0.20 microg/ml RPP. Superoxide generation was measured by superoxide dismutase-inhibitable cytochrome C reduction. RESULTS: In 30 minutes, 22:6OOH-activated PMNs produced 11.10 +/- 0.68 nanomoles superoxide, and production was suppressed 72% by RPP. Under the same conditions, fMLP induced production of 34.6 +/- 2.77 nanomoles superoxide, and RPP inhibited 60% of production. In the PMN cell-free systems, 100 microM 22:6OOH induced 74.7 nanomoles superoxide per milligram plasma membrane proteins per 5 minutes, and RPP suppressed 50% of production. These results were comparable with those generated by arachidonate, a known stimulator for this system. RPP was effective only when it was added before assembly of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. CONCLUSIONS: The inflammation-mediated retinal peroxidation product 22:6OOH significantly activates resting PMNs, either in intact cells or in cell-free preparations, to increase further the release of superoxide from PMNs, thus accelerating inflammation-mediated tissue damage. This profound amplification process seems to be effectively downregulated by an RPE-generated protein RPP.  (+info)

Concentration of serum lipids and aortic lesion size in female and male apo E-deficient mice fed docosahexaenoic acid. (7/1678)

Apolipoprotein (apo) E-deficient mice were fed an atherogenic diet with either 1% ethyl ester docosahexaenoic acid (DHA) or safflower oil (SO) as a source of linoleic acid for 8 week. Both genders fed DHA had higher proportions of eicosapentaenoic acid and DHA, and lower proportions of linoleic and arachidonic acids in the liver and serum phospholipids than those fed SO. Males fed DHA had greater liver weight and tended to have higher concentrations of serum lipids and liver cholesterol than those fed SO, and there were opposite trends in females. Dietary fats and gender led to no significant effect on lesion sizes in aortic arch and thoracic plus abdominal aorta. These results indicate that the interactive action of sex-related factor(s) with dietary polyunsaturated fatty acids is involved in metabolic changes of serum lipids in apoE-deficient mice, and addition of DHA, compared with addition of SO, is not effective to abolish the atherosclerosis in this animal model.  (+info)

Cytotoxic drugs efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. (8/1678)

Experimental studies indicated that long-chain polyunsaturated fatty acids may increase sensitivity of mammary tumours to several cytotoxic drugs. To evaluate this hypothesis in breast cancer, we have prospectively studied the association between levels of fatty acids stored in breast adipose tissue and the response of the tumour to chemotherapy in 56 patients with an initially localized breast carcinoma. Adipose breast tissue was obtained at the time of biopsy, and individual fatty acids were measured as a percentage of total fatty acids using capillary gas chromatography. Patients then received primary chemotherapy, combining mitoxantrone, vindesine, cyclophosphamide and 5-fluorouracil every 4 weeks. Tumour size was reassessed after three cycles of chemotherapy. Tumour response was evaluated according to World Health Organization criteria. Complete or partial response to chemotherapy was achieved in 26 patients (47%). Level of n-3 polyunsaturated fatty acids in adipose tissue was higher in the group of patients with complete or partial response to chemotherapy than in patients with no response or with tumour progression (P < 0.004). Among n-3 polyunsaturated, only docosahexaenoic acid (22:6n-3) was significantly associated with tumour response (P < 0.005). In a logistic regression analysis taking into account age, body mass index and tumour size, 22:6 n-3 level proved to be an independent predictor for chemosensitivity (P = 0.03). These results suggest that, in breast cancer, 22:6 n-3 may increase the response of the tumour to the cytotoxic agents used.  (+info)

TY - JOUR. T1 - Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. AU - Song, Jin Hyang. AU - Miyazawa, Teruo. PY - 2001. Y1 - 2001. N2 - The effect of dietary docosahexaenoic acid (DHA, 22:6n-3) oil with different lipid types on lipid peroxidation was studied in rats. Each group of male Sprague-Dawley rats was pair fed 15% (w/w) of either DHA-triglycerides (DHA-TG), DHA-ethyl esters (DHA-EE) or DHA-phospholipids (DHA-PL) for up to 3 weeks. The palm oil (supplemented with 20% soybean oil) diet without DHA was fed as the control. Dietary DHA oils lowered plasma triglyceride concentrations in rats fed DHA-TG (by 30%), DHA-EE (by 45%) and DHA-PL (by 27%), compared to control. The incorporation of dietary DHA into plasma and liver phospholipids was more pronounced in the DHA-TG and DHA-EE group than in the DHA-PL group. However, DHA oil intake negatively influenced lipid peroxidation in both plasma and liver. ...
TY - JOUR. T1 - Effect of docosahexaenoic acid supplementation on inflammatory cytokine levels in infants at high genetic risk for type 1 diabetes. AU - The Type 1 Diabetes TrialNet Nutritional Intervention to Prevent (NIP) Type 1 Diabetes Study Group. AU - Chase, H. Peter. AU - Boulware, David. AU - Rodriguez, Henry. AU - Donaldson, David. AU - Chritton, Sonia. AU - Rafkin, Lisa. AU - Krischer, Jeffrey. AU - Skyler, Jay S. AU - Clare-Salzler, Michael. AU - Lescheck, E.. AU - Krause Steinrauf, H.. AU - Azare, S. M.. AU - Adams, S.. PY - 2015/6/1. Y1 - 2015/6/1. N2 - Objective: Type 1 diabetes (T1D) results from the inflammatory destruction of pancreatic β-cells. In this study, we investigated the effect of docosahexaenoic acid (DHA) supplementation on stimulated inflammatory cytokine production in white blood cells (WBC) from infants with a high genetic risk for T1D. Research design and methods: This was a multicenter, two-arm, randomized, double-blind pilot trial of DHA supplementation, ...
Patients with Uncontrolled Epilepsy Have Low Levels of Fatty Acids Omega-3 fatty acids are crucial to the proper development and function of cell membranes...
From what Ive read the only strain of Epilepsy which can cause sudden death is status epilepticus. Very rare. I dont know if it falls as high as 20...
The complexities of cell function in the central nervous system are sustained by intra- and intercellular signaling networks driven by synaptic activity, neurotrophins, gene programs and other factors. The molecular organization and functional contribution of cellular membranes are pivotal in the myriad of molecular circuitries of the CNS. Docosahexaenoic acid, an omega-3 fatty acid, is concentrated and avidly retained in membrane phospholipids of the nervous system, notably in photoreceptors and synapses. DHA is implicated in brain and retina function, aging, and neurological and psychiatric/behavioral illnesses. The discovery of neuroprotectin D1, the first docosanoid (a bioactive derivative of DHA), is allowing scientists to address fundamental questions concerning the biology of omega-3 fatty acids and their significance to brain function and the mechanisms of action in disease models such as stroke, epilepsy and neurodegeneration. The name neuroprotectin D1 was suggested based on the ...
Docosahexaenoic acid supplementation promotes erythrocyte antioxidant defense and reduces protein nitrosative damage in male athletes.
Protectin D1 also known as neuroprotectin D1 (when it acts in the nervous system) and abbreviated most commonly as PD1 or NPD1 is a member of the class of specialized proresolving mediators. Like other members of this class of polyunsaturated fatty acid metabolites, it possesses strong anti-inflammatory, anti-apoptotic and neuroprotective activity. PD1 is an aliphatic acyclic alkene 22 carbons in length with two hydroxyl groups at the 10 and 17 carbon positions and one carboxylic acid group at the one carbon position. Specifically, PD1 is an endogenous stereoselective lipid mediator classified as an autocoid protectin. Autacoids are enzymatically derived chemical mediators with distinct biological activities and molecular structures. Protectins are signaling molecules that are produced enzymatically from unsaturated fatty acids. Their molecular structure is characterized by the presence of a conjugated system of double bonds. PD1, like other protectins, is produced by the oxygenation of the ω-3 ...
OBJECTIVE To hypothesize that higher intake of docosahexaenoic acid, an n-3 long chain polyunsaturated fatty acid, would increase duration of gestation and birth weight in US women. METHODS This was a randomized, double-blind, controlled, clinical trial. Subjects were enrolled in an ambulatory clinic where they received prenatal care. This was a population-based sample. Most subjects received government assistance for medical care and most were black (73%). Subjects were enrolled between the 24th and 28th week of pregnancy and consumed docosahexaenoic acid (33 or 133 mg) from eggs until parturition. Gestational age and birth weight were the main study outcomes. Infant length and head circumference, preterm birth, and low birth weight were secondary outcomes. RESULTS Eighty-three percent of subjects completed the study (291 of 350 enrolled). No subject was discontinued for an adverse event. After controlling for important predefined risk factors and confounding variables, gestation increased by 6.0 +
TY - JOUR. T1 - Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients. AU - Kale, Anvita. AU - Joshi, Sadhana. AU - Naphade, Nilesh. AU - Sapkale, Swati. AU - Raju, M. S.V.K.. AU - Pillai, Anilkumar R. AU - Nasrallah, Henry. AU - Mahadik, Sahebarao P.. PY - 2008/1/1. Y1 - 2008/1/1. N2 - Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p = , 0.01) whereas higher in CSF (p = , 0.01) in male , female patients. This altered DHA ...
Low levels of the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) have been reported in the brains of patients with Alzheimers disease (AD), as has evidence for an AD protective effect of increased marine fish consumption, a main source of DHA. This week, Lim et al. test whether DHA has a direct effect on amyloid production in a mouse model of AD. The studies support a role for DHA in reducing amyloid burden even at a relatively late stage in this animal model.
article{75fb11cd-9b79-4275-9d9c-4adabc269474, abstract = {PURPOSE:: To examine the retinal inflammatory response to ischemia-reperfusion in nondiabetic and diabetic rats injected with either an omega-3-polyunsaturated fatty acid (docosahexaenoic acid [DHA]) or a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (pravastatin). METHODS:: Diabetes was induced by an intraperitoneal injection of streptozocin, and retinal ischemia was induced by ligation of the optic nerve and vessels, followed by reperfusion for 1 hour or 24 hours. Five minutes before surgery, an intravenous injection of DHA, pravastatin, or vehicle (ethanol) was administered. The mRNA expressions of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, caspase-1, IL-1beta, P-selectin, vascular cellular adhesion molecule (VCAM)-1, and intercellular adhesion molecule (ICAM)-1 were compared between ischemic and nonischemic retinas as well as diabetic and nondiabetic nonischemic retinas. RESULTS:: Ischemia induced increased ...
Effects of docosahexaenoic acid on large-conductance Ca2+-activated K+ channels and voltage-dependent K+ channels in rat coronary artery smooth muscle cells.: D
Marine oils are important to human nutrition as the major source of docosahexaenoic acid (DHA), a key omega-3 long-chain (≥C20) polyunsaturated fatty acid (n-3 LC-PUFA) that is low or lacking in terrestrial plant or animal oils. The inclusion of fish oil as main source of n-3 LC-PUFA in aquafeeds is mostly limited by the increasing price and decreasing availability. Fish oil replacement with cheaper terrestrial plant and animal oils has considerably reduced the content of n-3 LC-PUFA in flesh of farmed Atlantic salmon. Novel DHA-enriched oils with high alpha-linolenic acid (ALA) content will be available from transgenic oilseeds plants in the near future as an alternative for dietary fish oil replacement in aquafeeds. As a preliminary validation, we formulated an oil blend (TOFX) with high DHA and ALA content using tuna oil (TO) high in DHA and the flaxseed oil (FX) high in ALA, and assessed its ability to achieve fish oil-like n-3 LC-PUFA tissue composition in Atlantic salmon smolts. We ...
By a News Reporter-Staff News Editor at VerticalNews Science -- DURHAM, N.C. - Physicians and patients who are wary of addiction to pain medication and opioids may soon have a healthier and more natural alternative. A Duke University study revealed that a derivative of DHA (docosahexaenoic acid), a main ingredient of over-the-counter fish oil supplements, can sooth and prevent neuropathic pain caused by injuries to the sensory system. The results appear online in the Annals of Neurology. The research focused on a compound called neuroprotectin D1=protectin D1 (NPD1=PD1), a bioactive lipid produced by cells in response to external stimuli. NPD1=PD1 is present in human white blood cells, and was first identified based on its ability to resolve abdominal and brain inflammation. These compounds are derived from omega-3 fatty acids found in fish oil, but are 1,000 times more potent than their precursors in reducing inflammation, said Ru-Rong Ji, professor of anesthesiology and neurobiology at Duke ...
Some evidence shows that fetal development may be a critical for the development of allergies and asthma later in life, and that DHA may play a key role in the development of the immune system. This study aimed to investigate the effects of DHA supplementation during this time period on the incidence of allergies and asthma up to six years of age. Women in the KUDOS cohort were given 600 mg of DHA or a placebo during their second and third trimesters of pregnancy, and their offspring were followed up to six years of age. Two-hundred thirty infants were included. Their medical records were collected until six years of age or until their records could no longer be acquired if the infant dropped out before six years of age. All records were coded and allergic diagnoses were examined for this study. These diagnoses were grouped into three categories, skin allergies, wheeze/asthma, and other allergies. Associations and relative risks were calculated for each type of allergy diagnosis and no ...
Dendritic cells (DC) are professional antigen presenting cells which link innate and adaptive immunity through recognition and processing of pathogens, migration to secondary lymph nodes, presentation of antigens to naïve T cells and contribution to T cell proliferation and differentiation into various classes of effector T cells. N-3 fatty acids including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were reported to have protective anti-inflammatory effects in clinical studies and animal models of colitis, sepsis, and stroke. However, the mechanisms involved in the anti-inflammatory function of EPA and DHA are not elucidated. Recent studies, including our own, investigated the effect of n-3 fatty acids on dendritic cells, and reported that DHA reduced the capacity of human monocyte-derived DC (hMo-DC) and of murine bone marrow derived conventional DC (BMDC) to produce IL-12 and to stimulate CD4+ T cell proliferation. The objectives of this thesis were to provide a comprehensive ...
Uncoupling protein 3 (UCP3) is a mitochondrial membrane transporter that is expressed mainly in skeletal muscle where it plays an important role in energy expenditure and fat oxidation. In this study, we investigated the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on UCP3 gene expression in C2C12 muscle cells. EPA and DHA up-regulated UCP3 mRNA level in a dose-dependent manner and similarly increased UCP3 promoter activity in C2C12 muscle cells. To determine whether AMP-activated protein kinase (AMPK) signaling may also directly regulate UCP3 expression, 5′-amino-4-imidazolecarboxamide-ribonucleoside (AICAR), an AMP analog that activates AMPK, was treated in C2C12 muscle cells. AICAR showed additive effects with EPA or DHA on the UCP3 promoter activation. These results indicate that EPA and DHA directly regulate the gene expression of UCP3, potentially through AMPK-mediated pathway in C2C12 muscle cells.
Abstract: : Purpose: In a placebo-controlled trial to elevate blood-DHA levels in patients with XLRP, the goal was to assess the potential benefit of supplementation in altering disease progression. However, DHA (22:6w3) is a highly unsaturated long-chain fatty acid and is considered a target molecule for free-radical oxidative damage. Thus, nutritional provision of DHA in a treatment protocol for XLRP may be contra-indicated. Here, non-ocular adverse events as well as antioxidant and blood lipid profiles were assessed at the conclusion of a 4-year supplementation trial. Methods: Patients (n=44) were enrolled in a randomized, double-blind, clinical trial and provided either DHA (400mg/day) or a corn/soy oil placebo. Blood samples were collected every six months for the duration of the trial. Biological safety analysis included blood lipid fatty acid determination, plasma vitamin A & E levels, platelet aggregation, and plasma antioxidant capacity. Results: DHA supplementation elevated blood lipid ...
TY - JOUR. T1 - Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates. AU - Atwell, Kerryn. AU - Collins, Carmel. AU - Sullivan, Thomas. AU - Ryan, Philip. AU - Gibson, Robert. AU - Makrides, Maria. AU - McPhee, Andrew. PY - 2013/1. Y1 - 2013/1. N2 - Aim: To determine the effect of neonatal docosahexaenoic acid (DHA) supplementation in preterm infants on later respiratory-related hospitalisations. Methods We enrolled 657 infants in a multicentre, randomised, controlled trial designed to study the long-term efficacy of higher dose dietary DHA in infants born ,33 weeks gestation. Treatment was with high DHA (∼1%) compared with standard DHA (∼0.3%) in breast milk or formula, given from the first week of life to term equivalent. Parent-reported hospital admissions to 18 months corrected age were recorded. The proportion of children hospitalised for lower respiratory tract (LRT) conditions and the mean number of hospitalisations per infant were ...
TY - JOUR. T1 - Is the omega-3 index a valid marker of intestinal membrane phospholipid EPA+DHA content?. AU - Gurzell, Eric A.. AU - Wiesinger, Jason A.. AU - Morkam, Christina. AU - Hemmrich, Sophia. AU - Harris, William. AU - Fenton, Jenifer I.. PY - 2014. Y1 - 2014. N2 - Despite numerous studies investigating n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation and inflammatory bowel diseases (IBD), the extent to which dietary n-3 LCPUFAs incorporate in gastrointestinal (GI) tissues and correlate with red blood cell (RBC) n-3 LCPUFA content is unknown. In this study, mice were fed three diets with increasing percent of energy (%en) derived from eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA). Dietary levels reflected recommended intakes of fish/fish oil by the American Heart Association. We analyzed the FA composition of phospholipids extracted from RBCs, plasma, and GI tissues. We observed that the 0.1%en EPA+DHA diet was sufficient to significantly increase the omega-3 ...
Results Blood DHA increased in children supplemented with DHA (0.65%, 95% CI 0.30% to 1.10% for the DHA 250 mg group and 1.15%, 0.87% to 1.43% for the DHA 500 mg group). The odds of more severe versus less severe liver steatosis after treatment was lower in children treated with DHA 250 mg/day (OR = 0.01, 0.002 to 0.11, p ,0.001) and DHA 500 mg/day (OR = 0.04, 0.002 to 0.46, p = 0.01) as compared to placebo but there was no difference between the DHA groups (p = 0.4). Insulin sensitivity index increased and triglycerides decreased to a similar degree in both DHA groups as compared to placebo but there was no effect on alanine transaminase and body mass index.. ...
Changing dietary fatty acid composition in modern diet influences the prevalence of obesity. Increasing evidences suggest favorable effects of n-3 PUFA for protecting against obesity and the metabolic syndrome. However, the regulation of n-3 PUFA in adipose is still unclear. Thus, this study addressed metabolism of different dietary fats in the adipose tissue of porcine model. Eight-week-old cross-bred pigs were randomly assigned to three groups and fed a 2% fat diet for 30 days from either soybean oil (SBO), docosahexaenoic acid (DHA) or beef tallow. An in vitro experiment was conducted in which linoleic acid (LA), DHA or oleic acid (OA) were added to represent the major fatty acid in the SBO-, DHA- or BT- diets, respectively. Adipocytes size and lipid metabolism related genes were analyzed. Plasma triacylglycerol (TAG) was lower in DHA- than in BT-fed pigs, and the product of lipolysis, glycerol was highest in BT-fed pigs. In addition, expression of the lipolytic genes, adipose triglyceride lipase and
RISHON supply vegetarian Algae docosahexaenoic acid powder, also known as Algal Docosahexaenoic acid Powder, is a free flowing fine powder manufactured by the microencapsulation technology. Algae Docosahexaenoic acid Powder is made fromRead More…. ...
Facebook Dr. Anil Home page AutismItsGutStupid Wall Street Journal Best Seller Dr. Ms Seven-X Plan for Digestive Health Polyunsaturated fatty acids like arachidonic acid (ARA) and docosahexaenoic acid (DHA) are believed to play a critical role in growth and development of brain including the signal messaging system in the brain. Docosahexaenoic Acid supplementation is frequently used to treat kids with autism. Dr. Voigt and colleagues recently conducted a randomized placebo controlled trial in 48 kids. Half of them received 200 mg DHA every day while the rest received placebo. Clinical Global Impressions-Improvement (CGI-I) scales was used. At the end of 6 months, although the DHA group showed a 431% increase in DHA levels, the investigators found that DHA did not have beneficial impact on core behavior of autistic kids as compared to those on placebo. However, Voigt and colleagues conceded that the negative results may have been as a result...
Read Docosahexaenoic acid (DHA) enhances the therapeutic potential of neonatal neural stem cell transplantation post-Traumatic brain injury, Behavioural Brain Research on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
ABSTRACTResolution of inflammation in the periphery was once thought to be a passive process, but new research now suggests it is an active process mediated by specialized pro-resolving lipid mediators (SPM) derived from omega-3 polyunsaturated fatty acids (n-3 PUFA). However, this has yet to be ill
The omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are considered essential because they cant be produced by your body. They must be taken in through diet. A study published in Neurology, the medical journal of the American Academy of Neurology, suggests that a diet lacking omega-3s might lead to faster brain aging, potentially…
Dietary balance of long-chain fatty acids may influence processes involving leukocyte-endothelial interactions, such as atherogenesis and inflammation, that involve increased endothelial expression of leukocyte adhesion molecules, or endothelial activation. We compared the ability of various saturated, monounsaturated, and polyunsaturated fatty acids to modulate endothelial activation. Consumption of the n-3 fatty acid docosahexaenoic acid (DHA; 22:6n-3) reduced endothelial expression of vascular cell adhesion molecule 1 (VCAM-1), E-selectin, intercellular adhesion molecule 1 (ICAM-1), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4, tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration (IC(50)) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations. The magnitude of this effect paralleled its incorporation into cellular phospholipids. DHA also reduced the adhesion of human monocytes and monocytic U937 cells to ...
Neuroscience. 2009 Mar 3;159(1):296-307. doi: 10.1016/j.neuroscience.2008.12.006. Epub 2008 Dec 14. Research Support, Non-U.S. Govt
Fu YQ, Zheng JS, Yang B, Li D. Effect of individual omega-3 fatty acids on the risk of prostate cancer: a systematic review and dose-response meta-analysis of prospective cohort studies. Am J Clin Nutr 1995;62:761-8. 1990;40(6):700-704. What precautions should you take while using Docosahexaenoic Acid? View abstract. Developmental & Reproductive Toxicity . Lopez-Alarcon, M., Furuya-Meguro, M. M., Garcia-Zuniga, P. A., and Tadeo-Pulido, I. Development of visual acuity in relation to plasma and erythrocyte omega-6 and omega-3 fatty acids in healthy term gestation infants. Here are 12 science-backed health benefits of DHA. However, some research shows that taking DHA might improve memory of events and visual and spatial learning in people with age-related mental decline. Lauritzen L, Hoppe C, Straarup EM, Michaelsen KF. Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, sperm, testicles and retina.It can be ...
J:234197 Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR, Silver DL, Mfsd2a Is a Transporter for the Essential omega-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. J Biol Chem. 2016 May 13;291(20):10501-14 ...
A study was recently conducted to determine the effect of supplementing the diet of dairy cows with several levels of an algal product high in the long chain fatty acid docosahexaenoic acid (DHA).
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject-specific sections.
Aim: The purpose of this study was to investigate the influence of docosahexaenoic acid (DHA) on muscle damage and inflammation following an acute eccentric exercise bout. Methods: A double-blind placebo-controlled, study was performed using 41 healthy, untrained males aged 18-28 y who consumed either 2 g/d DHA or placebo (PL, corn oil) for 32 days. Supplements were consumed for 28 days prior to exercise. Participants completed an eccentric exercise procedure of the elbow flexors at 140% of 1-RM (6 sets x 10 repetitions). The time under tension (TUT) for each set of eccentric contractions was recorded manually from the investigators voice commands. Fasted blood samples for prostaglandin E2 (PGE2), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL1-ra), C-reactive protein and creatine kinase (CK) were assessed on days 1, 2 and 4. Fasted serum DHA was measured at baseline (day -28) and on day 1. Peak isometric strength of the elbow flexors, delayed-onset muscle soreness, and range of ...
Polyunsaturated phospholipids are known to be important with regard to the biological functions of essential fatty acids, for example, involving neural tissues such as the brain and retina. Here we have employed two complementary structural methods for the study of polyunsaturated bilayer lipids, viz. deuterium ((2)H) NMR spectroscopy and molecular dynamics (MD) computer simulations. Our research constitutes one of the first applications of all-atom MD simulations to polyunsaturated lipids containing docosahexaenoic acid (DHA; 22:6 cis-Delta(4,7,10,13,16,19)). Structural features of the highly unsaturated, mixed-chain phospholipid, 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine (PDPC), have been studied in the liquid-crystalline (L(alpha)) state and compared to the less unsaturated homolog, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). The (2)H NMR spectra of polyunsaturated bilayers are dramatically different from those of less unsaturated phospholipid bilayers. We show ...
Yang B, Fritsche KL, Beversdorf DQ, Gu Z, Lee JC, Folk WR, Greenlief CM, Sun GY. (2019). Yin-Yang Mechanisms Regulating Lipid Peroxidation of Docosahexaenoic Acid and Arachidonic Acid in the Central Nervous System. Front Neurol. 10:642. doi: 10.3389/fneur.2019.00642. eCollection 2019. Review. [PubMed]. Yang B, Li R, Woo T, Browning JD Jr, Song H, Gu Z, Cui J, Lee JC, Fritsche KL, Beversdorf DQ, Sun GY, Greenlief CM. (2019). Maternal Dietary Docosahexaenoic Acid Alters Lipid Peroxidation Products and (n-3)/(n-6) Fatty Acid Balance in Offspring Mice. Metabolites. 9(3). doi: 10.3390/metabo9030040. [PubMed]. Sun GY, Li R, Yang B, Fritsche KL, Beversdorf DQ, Lubahn DB, Geng X, Lee JC, Greenlief CM. (2019). Quercetin Potentiates Docosahexaenoic Acid to Suppress Lipopolysaccharide-induced Oxidative/Inflammatory Responses, Alter Lipid Peroxidation Products, and Enhance the Adaptive Stress Pathways in BV-2 Microglial Cells. Int J Mol Sci. 20(4). doi: 10.3390/ijms20040932. [PubMed]. Teng T, Ridgley DM, ...
Supplementation With Highly Purified Docosahexaenoic Acid Ethyl Ester Was Associated With Enhancement of Hepatic Fatty Acid Oxidation and Greater Apparent Absorption of Docosahexaenoic Acid in Rats
Organelle remodeling processes are evolutionarily conserved and involved in cell functions during development, aging, and cell death. Some endogenous and exogenous molecules can modulate these processes. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has mainly been considered as a modulator of plasma membrane fluidity in brain development and aging, while DHAs role in organelle remodeling in specific neural cell types at the ultrastructural level remains largely unexplored. DHA is notably incorporated into dynamic organelles named lipid bodies (LBs). We hypothesized that DHA could attenuate the inflammatory response in lipopolysaccharide (LPS)-activated microglia by remodeling LBs and altering their functional interplay with mitochondria and other associated organelles. We used electron microscopy to analyze at high spatial resolution organelle changes in N9 microglial cells exposed to the proinflammogen LPS, with or without DHA supplementation. Our results revealed that DHA
DHA has been tested in clinical trials by itself and as part of other food-supplement formulations.. In 2000, Karolinska University Hospital began the OmegAD trial, which evaluated a six-month course of treatment with a DHA-containing fish oil formulation called EPAX 1050 TG in 204 people with mild to moderate AD, of whom 174 completed the study. The treatment and placebo groups did not differ on either of the main outcome measures, decline on the MMSE and ADAS-cog, or on neuropsychiatric symptoms overall. However, analysis of a small subgroup of the 32 mildest cases did suggest less decline on the MMSE, though not ADAS-cog, and a similar slowing of decline appeared to occur in the placebo group once switched to DHA after six months (Freund-Levi et al., 2006; see news and commentary; Freund-Levi et al., 2008). Substudies suggested that DHA treatment increased CSF levels of DHA and other fatty acids and decreased levels of tau, as well as changing expression of inflammation-related genes and ...
Dha Docosahexaenoic Acid list and information including what is Dha Docosahexaenoic Acid, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
Dha Docosahexaenoic Acid list and information including what is Dha Docosahexaenoic Acid, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
Docosahexaenoic acid (DHA) and arachidonic acid (ARA) are major components of the cerebral cortex and visual system, where they play a critical role in neural development. We quantitatively mapped fatty acids in 26 regions of the four-week-old breastfed baboon CNS, and studied the influence of dietary DHA and ARA supplementation and prematurity on CNS DHA and ARA concentrations. Baboons were randomized into a breastfed (B) and four formula-fed groups: term, no DHA/ARA (T-); term, DHA/ARA supplemented (T+); preterm, no DHA/ARA (P-); preterm and DHA/ARA supplemented (P+). At four weeks adjusted age, brains were dissected and total fatty acids analyzed by gas chromatography and mass spectrometry. DHA and ARA are rich in many more structures than previously reported. They are most concentrated in structures local to the brain stem and diencephalon, particularly the basal ganglia, limbic regions, thalamus and midbrain, and comparatively lower in white matter. Dietary supplementation increased DHA in all
Novel DHA-enriched oils with high α-linolenic acid (ALA) content will be available in the near future as an alternative for dietary fish oil replacement in aquafeeds. As preliminary validation, we 1) assessed the ability of a diet containing a formulated oil blend (tuna oil + flaxseed oil, TOFX) with high DHA and ALA content to achieve fish oil-like omega-3 long-chain (≥C20) polyunsaturated fatty acids (n-3 LC-PUFA) tissue composition in Atlantic salmon smolts, and 2) applied liver proteomics as exploratory approach to understand the consequent nutritional changes. Comparisons were made on fish fed a fish oil-based diet (FO) and a commercial-like oil blend diet (fish oil + poultry oil, FOPO) over 89 days. Growth and feed efficiency ratio were lower on the TOFX diet. Fish tissue concentration of n-3 LC-PUFA and the n-3:n-6 ratio were significantly higher for TOFX than for FOPO, but not higher than for FO, while tissue retention efficiency of n-3 LC-PUFA was promoted by TOFX relative to FO. Proteomics
Animals given both the DHA infusion and the DHA-enriched diet recovered motor function faster than those given just the DHA infusion. However, the difference in scores did not reach statistical significance, possibly because of the variability in scores and the relatively small differences between the two DHA-treated groups. The investigators noted that in spite of the lack of significant differences, animals given both the DHA-rich diet and the DHA infusion fared better than the DHA-infused animals. Providing DHA only in the diet without the infusion did not improve the animals recovery.. In addition to the benefits of DHA on functional recovery, the investigators reported that DHA infusion plus the DHA-enriched diet was associated with fewer nerve cells lost and less damage to the nerve cell axons. The investigators noted that provision of DHA immediately following the injury was essential for protecting the nerve cells and for functional improvement. A DHA-enriched diet alone was ...
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Welcome to Fats of Life. This is a hub for health on the benefits of EPA and DHA omega-3s intended only for medical practitioners.. If you are a patient researching omega-3s please visit our consumer website alwaysomega3s.com. ...
Docosahexanoic acid + folic acid + methylcobalamin is used in the treatment of .get complete information about docosahexanoic acid + folic acid + methylcobalamin including usage, side effects, drug interaction, expert advice along with medicines associated with docosahexanoic acid + folic acid + methylcobalamin at 1mg.com
As is known to all, the intracellular Rhodamine123 concentrations in MDR cells were extremely lower than sensitive cells. Meanwhile, the molecular mechanism of MDR is not fully clarification. It is well known that formation of MDR is complicated process and involves multiple factors, including increased drug efflux, alteration the apoptotic response, and change of DNA damage repair capacity in drug resistance tumor cells [16]. Among these factors, the most important reason is the drug efflux resulting from enhancement of drug transporter activity. These transporters originated from ATP-binding cassette (ABC) transporters super family such as P-gp, MRP1, MRP2, BCRP and LRP [17]. Accumulated evidences have indicated that over expression of P-gp directly contributes to MDR, and blocking P-gp drug pump functions and suppressing its expression might enhance the effects of chemotherapeutic drugs on MDR cancer cells [18]. Giada has reported that they reverse MDR in colon cancer cells by inhibiting the ...
5-year-old children whose mothers received modest DHA supplementation for the first 4mos of breastfeeding performed better on a test of sustained attention.
A high intake of the omega-3 fatty acid docosahexaenoate [docosahexaenoic acid (DHA)] has been associated with systemic antiinflammatory effects and cardiovascular protection. Cyclooxygenase (COX)-2 is responsible for the overproduction of prostaglandins (PG) at inflammatory sites, and its expression is increased in atheroma. We studied the effects of DHA on COX-2 expression and activity in human saphenous vein endothelial cells challenged with proinflammatory stimuli. A ≥24-h exposure to DHA reduced COX-2 expression and activity induced by IL-1, without affecting COX-1 expression. DHA effect depended on the NF-κB-binding site in the COX-2 promoter. EMSAs confirmed that DHA attenuated NF-κB activation. Because MAPK, PKC, and NAD(P)H oxidase all participate in IL-1-mediated COX-2 expression, we also tested whether these enzymes were involved in DHA effects. Western blots showed that DHA blocked nuclear p65 NF-κB subunit translocation by decreasing cytokine-stimulated reactive oxygen species ...
The company's products include the omega-3 fatty acid docosahexaenoic acid (DHA) and arachidonic acid (ARA), an omega-6 fatty ... docosahexaenoic acid), and a fungus (Mortierella alpina) that yields ARA (arachidonic acid), another essential fatty acid. ... Docosahexaenoic acid (DHA). Retrieved 8 December 2020. Martinez, M., Tissue levels of polyunsaturated fatty acids during early ... Koletzko, B.; Carlson, S.E.; van Goudoever, J.B. Should infant formula provide both omega-3 DHA and omega-6 arachidonic acid? ...
Fish are high in vitamin D. Fish also contain docosahexaenoic acid (DHA), which help with a variety of neurological ... Horrocks LA, Yeo YK (September 1999). "Health benefits of docosahexaenoic acid (DHA)". Pharmacological Research. 40 (3): 211-25 ...
Capric acid,[1] n-Capric acid, n-Decanoic acid, Decylic acid, n-Decylic acid, C10:0 (Lipid numbers) ... Decanoic acid (capric acid, C10:0) is a saturated fatty acid. Its formula is CH3(CH2)8COOH. Salts and esters of decanoic acid ... Two other acids are named after goats: caproic (a C6:0 fatty acid) and caprylic (a C8:0 fatty acid). Along with decanoic acid, ... Nonanoic acid, a medium-chain fatty acid, also with antiseizure activity. References[edit]. *^ a b c d n-Decanoic acid in ...
... is the first fatty acid produced during fatty acid synthesis and is the precursor to longer fatty acids. As a ... Palmitic acid, or hexadecanoic acid in IUPAC nomenclature, is the most common saturated fatty acid found in animals, plants and ... Palmitic acid strongly boosts metastasis in mouse models of human oral cancer cells. Among all fatty acids, it has the ... Aluminium salts of palmitic acid and naphthenic acid were combined during World War II to produce napalm. The word "napalm" is ...
Horrocks, Lloyd A.; Yeo, Young K. (September 1999). "Health Benefits of Docosahexaenoic Acid (DHA)". Pharmacological Research. ... Fish also contain docosahexaenoic acid (DHA), which help with a variety of neurological dysfunctions.[59] ...
There is docosahexaenoic acid along with saxitoxin. Lilly, E. L.; Halanych, K. M.; Anderson, D. M. (2007). "Species boundaries ...
Heinemann, K.M.; Bauer, J.E. (2006). "Docosahexaenoic acid and neurologic development in animals". Journal of the American ... and retinal functions in healthy puppies fed foods fortified with docosahexaenoic acid-rich fish oil from 8 to 52 weeks of age ... DHA is the main n-3 fatty acid and can be obtained as DHA itself from dietary sources such as fish and fish oils, or as the DHA ... Adequate intake and recommended allowance levels of 85g/kg (DM) of total fat (8.5%), and 0.5g/kg (DM) of omega 3 fatty acids ( ...
Sakayori, Nobuyuki; Osumi, Noriko (2017). "The role of docosahexaenoic acid in brain development". Vitamins. The Vitamin ... OSUMI, Noriko (2011). "Polyunsaturated Fatty Acids and Fatty Acid Binding Protein Involvements in Neurogenesis". Oleoscience. ... Osumi, Noriko (2016). "Functional analysis of fatty acid signals in brain development". Reports of Research Assisted by the ... Sakayori, Nobuyuki; Osumi, Noriko (2018). "The role of essential fatty acids in brain development". Journal of Lipid Nutrition ...
It likewise metabolizes docosahexaenoic acid to epoxydocosapentaenoic acids (EDPs; primarily 19,20-epoxy-eicosapentaenoic acid ... vernolic acid (also termed leukotoxin) and coronaric acid (also termed isoleukotoxin); these linoleic acid epoxides cause ... see 20-Hydroxyeicosatetraenoic acid, epoxyeicosatetraenoic acid, and epoxydocosapentaenoic acid sections on activities and ... In particular, CYP2C9 metabolizes arachidonic acid to the following eicosatrienoic acid epoxide (EETs) stereoisomer sets: 5R,6S ...
2007). "Neurofurans: Novel indices of oxidant stress derived from docosahexaenoic acid". J Biol Chem. 283 (1): 6-16. doi: ... Neurofurans are 22-carbon compounds formed nonenzymatically by free radical mediated peroxidation of docosahexaenoic acid (DHA ... an ω-3 essential fatty acid. The neurofurans are similar to the isofurans and are formed under similar conditions of oxidative ...
Salem N, Litman B, Kim HY, Gawrisch K (September 2001). "Mechanisms of action of docosahexaenoic acid in the nervous system". ... Guesnet P, Alessandri JM (January 2011). "Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - ... DHA omega-3 is a major structural fatty acid in the brain and retina, and is naturally found in breast milk. It is important ... "Folic acid in diet: MedlinePlus Medical Encyclopedia". www.nlm.nih.gov. Archived from the original on 17 November 2015. ...
C. cohnii can acclimate a higher docosahexaenoic acid to polyunsaturated fatty acids ratio, however current studies are trying ... Jiang, Y; Chen, F (1999-12-01). "Effects of salinity on cell growth and docosahexaenoic acid content of the heterotrophic ... It is used industrially in the production of docosahexaenoic acid. Crypthecodinium cohnii is a heterotrophic non-photosynthetic ... "Production potential of docosahexaenoic acid by the heterotrophic marine dinoflagellate Crypthecodinium cohnii". Process ...
Salem N, Litman B, Kim HY, Gawrisch K (September 2001). "Mechanisms of action of docosahexaenoic acid in the nervous system". ... "Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations". ... "Folic acid, iron and pregnancy - Canada.ca". www.canada.ca. Archived from the original on 7 August 2017. Retrieved 25 August ... "Folic acid in diet: MedlinePlus Medical Encyclopedia". www.nlm.nih.gov. Archived from the original on 17 November 2015. ...
... -dependent neuroprotective signaling promoted by docosahexaenoic acid. Prostagl Leukot Essent Fatty Acids. ... Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proc Natl Acad Sci USA. 2005;102:10858-10863 ... Novel metabolism of docosahexaenoic acid in neural cells. J Biol Chem. 2007;282:18661-18665. [PubMed] [Google Scholar] 6. Kim ... Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3): Role of phosphatidylserine in antiapoptotic effect. J Biol ...
In addition, scientists argue that the Homo species was also able to obtain nutrients like docosahexaenoic acid from algae that ... Bradbury, Joanne (10 May 2011). "Docosahexaenoic Acid (DHA): An Ancient Nutrient for the Modern Human Brain". Nutrients. 3 (5 ... The site has been dated through radiocarbon dating to be between 110,000 BP and 61,000 BP through amino-acid racemization. Fire ...
Certain species produce large amounts of docosahexaenoic acid (DHA) and are grown commercially for production of this oil for ... "Expressed sequence tag analysis of marine fungus Schizochytrium producing docosahexaenoic acid". Journal of Biotechnology. 138 ... Yue Jiang; King-Wai Fan; Raymond Tsz-Yeung Wong & Feng Chen (2004). "Fatty acid composition and squalene content of the marine ... DHA synthesis in Schizochytrium does not involve membrane-bound desaturases or fatty acid elongation enzymes such as those ...
... docosahexaenoic acid (DHA, i.e. 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid), b) α-Linolenic acid (ALA, i.e. 9Z,12Z,15Z- ... 19Z-docosahexaenoic acid (10R,17S-diHDHA); 8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid (8S,15S-diHETE); 9S,16S-10E,12Z ... 10S,17S-Dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid. This compound is the 13Z cis-trans isomer of 10-epi-protectin D ( ... A maresin termed MaR isomer or 7-epi-MaR1, i.e. 7S,14S-dihydroxy-4Z,8E,10Z,12E,16Z,19Z-docosahexaenoic acid (see specialized ...
"Pharmacokinetics and Oxidation Parameters in Volunteers Supplemented with Microencapsulated Docosahexaenoic Acid". ... al Acids and acid esters Torularhodin 3',4'-Didehydro-β,γ-caroten-16'-oic acid Torularhodin methyl ester Methyl 3',4'-didehydro ... carotenedioic acid Crocetinsemialdehyde 8'-Oxo-8,8'-diapo-8-carotenoic acid Crocin Digentiobiosyl 8,8'-diapo-8,8'- ... Plants are known to use two different pathways for IPP production: the cytosolic mevalonic acid pathway (MVA) and the plastidic ...
Morita, Eiko; Kumon, Yasuyuki; Nakahara, Toro; Kagiwada, Satoshi; Noguchi, Tetsuko (2006). "Docosahexaenoic Acid Production and ... culture of the microalgae Schizochytrium limacinum on biodiesel-derived crude glycerol for producing docosahexaenoic acid". ...
... eicosapentaenoic acid and docosahexaenoic acid. The distinction between the omega-6 and omega-3 fatty acid substrates is ... Adrenic acid or 7(Z),10(Z),13(Z),16(Z)-docosatetraenoic acid, an abundant fatty acid in the adrenal gland, kidney, vasculature ... However, the CYP epoxygenases also metabolize other omega-6 fatty acids such as linoleic acid and the omega-3 fatty acids, ... see epoxyeicosatetraenoic acid). 4(Z),7(Z),10(Z),13(Z),16(Z),19(Z)-docosahexaenoic acid (DHA) is metabolized by the same CYP ...
RvD's are metabolites of the 22-carbon ω-3 fatty acid docosahexaenoic acid; see Specialized pro-resolving mediators#DHA-derived ... Eicosapentaenoic acid (EPA), i.e.i.e. 5Z, 8Z,11Z,14Z,17Z-eicosapentaenoic acid is an ω-3 fatty acid with five cis double bonds ... Mead acid, i.e. 5Z,8Z,11Z-eicosatrienoic acid, is an ω-9 fatty acid containing three cis double bonds, each located between ... Dihomo-gamma-linolenic acid (DGLA), 8Z, 11Z,14Z-eicosatrienoic acid is an ω-6 fatty acid with three cis double bonds, each ...
"Docosahexaenoic Acid (DHA): An Ancient Nutrient for the Modern Human Brain". Nutrients. 3 (5): 529-554. doi:10.3390/nu3050529. ... Docosahexaenoic acid) from algae that were especially beneficial and critical for brain evolution and, as mentioned in the ... The site has been dated through radiocarbon dating to be at 110,000 BP and 61,000 BP through amino acid racemization.[14] ...
There is broad scientific consensus that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) found in seafood are ... Harris, W S; Baack, M L (30 October 2014). "Beyond building better brains: bridging the docosahexaenoic acid (DHA) gap of ... Fish is a highly perishable product: the "fishy" smell of dead fish is due to the breakdown of amino acids into biogenic amines ... amino acid profiles and some physico-chemical properties". Food Chemistry. 71 (4): 475-482. doi:10.1016/S0308-8146(00)00175-8 ...
... blood docosahexaenoic acid and chronic diseases in Chinese rural populations". Comparative Biochemistry and Physiology A. 136 ( ...
Omega-3 fatty acids include docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). These two fatty acids have been shown ... Linoleic acid is a polyunsaturated fatty acid that is classified as an omega 6-fatty acid. Linoleic acid plays an important ... Omega 6-fatty acids can also have a slight anti-imflammatory role. Good sources of linoleic acid to look for in senior dog ... To ensure good health, it is important to provide dogs with the 22 amino acids which they require. Of these 22 amino acids, 12 ...
Bailes JE, Mills JD, Hadley K (January 2011). "Dietary Supplementation with the Omega-3 Fatty Acid Docosahexaenoic Acid in ... Bailes JE, Mills JD (September 2010). "Docosahexaenoic acid reduces traumatic axonal injury in a rodent head injury model". ... Tranexamic acid within three hours of a head injury decreases the risk of death. Certain facilities are equipped to handle TBI ... Mills JD, Bailes JE, Sedney CL, Hutchins H, Sears B (January 2011). "Omega-3 fatty acid supplementation and reduction of ...
Arterburn, LM (July 2008). "Algal-Oil Capsules and Cooked Salmon: Nutritionally Equivalent Sources of Docosahexaenoic Acid". ... In one study nitrogen deprivation for 72 hours caused the total fatty acid content (on a per cell basis) to increase by 2.4- ... Algal oil is used as a source of fatty acid supplementation in food products, as it contains mono- and polyunsaturated fats, in ... The unique composition of fatty acids of each species influences the quality of the resulting biodiesel and thus must be taken ...
... especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This characteristic is therefore widely used to feed ... Eicosapentaenoic and Docosahexaenoic Acids". Journal of Agricultural and Food Chemistry. 51 (8): 2237-41. doi:10.1021/jf025952y ... D.lutheri is capable of producing a large amount of polyunsaturated fatty acids, ...
... eicosapentaenoic acid which is metabolized to the Resolvin E's; docosahexaenoic acid which is metabolized to the resolvin D's, ... Specialized pro-resolving mediators are cell-derived metabolites of certain polyunsaturated fatty acids viz.: arachidonic acid ... n-3 docosapentaenoic acid which is metabolized to the n-3 docosapentaenoic acid-derived resolvins and n-3 docosapentaenoic acid ... Shinohara M, Serhan CN (2016). "Novel Endogenous Proresolving Molecules:Essential Fatty Acid-Derived and Gaseous Mediators in ...
"MYRISTIC ACID". ChemicalLand21.com. AroKor Holdings Inc. ശേഖരിച്ചത്: 17 June 2014.. *↑ Playfair, Lyon (2009). "XX. On a new fat ... 7.0 7.1 7.2 7.3 Tetradecanoic acid in Linstrom, P.J.; Mallard, W.G. (eds.) NIST Chemistry WebBook, NIST Standard Reference ... Docosahexaenoic (22:6). *9,12,15,18,21-Tetracosapentaenoic (24:5). *6,9,12,15,18,21-Tetracosahexaenoic (24:6) ... വിക്കിമീഡിയ കോമൺസിലെ Myristic acid എന്ന വർഗ്ഗത്തിൽ ഇതുമായി ബന്ധപ്പെട്ട കൂടുതൽ പ്രമാണങ്ങൾ ലഭ്യമാണ്. ...
... , also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication primarily ... 2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid ... Jones H, Blanc D, Cunliffe WJ (November 1980). "13-cis retinoic acid and acne". Lancet. 2 (8203): 1048-9. doi:10.1016/S0140- ... Lambert RW, Smith RE (March 1989). "Effects of 13-cis-retinoic acid on the hamster meibomian gland". The Journal of ...
... is inactivated by glucuronidation in the liver.[72] Lamotrigine is metabolized predominantly by glucuronic acid ... At high concentrations, it had no effect on spontaneous or potassium evoked amino acid release.[45] ... Early studies of lamotrigine's mechanism of action examined its effects on the release of endogenous amino acids from rat ... γ-aminobutyric acid (GABA) A receptor-mediated neurotransmission in rat amygdala, suggest that a GABAergic mechanism may also ...
... (TTA) is a synthetic fatty acid used as a nutritional supplement. ... Docosahexaenoic (22:6). *9,12,15,18,21-Tetracosapentaenoic (24:5). *6,9,12,15,18,21-Tetracosahexaenoic (24:6) ... 2002). "Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance". Journal of Lipid Research. ... One Phase I study showed no significant changes in the blood lipids or free fatty acids[4] and another showed that TTA ...
"A Long Lipid, a Long Name: Docosahexaenoic Acid". The Lipid Chronicles (2011-12-02). ... "Dietary trans fatty acids: review of recent human studies and food industry responses". Lipids 41 (11): 967-92. November 2006. ... "Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system". Sub-Cellular Biochemistry. Subcellular Biochemistry ...
... and docosahexaenoic acid (DHA). Vegetarian diets may also have a high ratio of omega-6 fatty acids to O3FAs, which inhibits the ... omega-6 fatty acids, dietary fibre, carotenoids, folic acid, vitamin C, vitamin E, potassium and magnesium. They are possibly ... Omega-3 fatty acidsEdit. Flaxseeds are a rich source of ALA, but contains negligible amounts of DHA and EPA, the long-chain ... Sanders, Thomas A.B. (2009). "DHA status of vegetarians". Prostaglandins, Leukotrienes and Essential Fatty Acids. 81 (2-3): 137 ...
... human placenta and its roles in placental preferential transfer of critically important nutrients such as docosahexaenoic acid, ... "Prostaglandins Leukotrienes and Essential Fatty Acids. Retrieved 19 July 2016.. *^ "Editorial Team". Nutrients. Retrieved 5 ... Duttaroy, Asim K.; Spener, Friedrich (October 2017). Cellular Proteins and Their Fatty Acids in Health and Disease. Wiley-VCH, ... Duttaroy, A (2009). "Transport of fatty acids across the human placenta: A review". Progress in Lipid Research. 48 (1): 52-61. ...
Docosahexaenoic acidEdit. ALOX5 acts in series with ALOX15 to metabolize the omega 3 fatty acid, docosahexaenoic acid (DHA, i.e ... Arachidonic acidEdit. ALOX5 metabolizes the omega-6 fatty acid, Arachidonic acid (AA, i.e. 5Z,8Z,11Z,15Z-eicosatrienoic acid), ... Eicosapentaenoic acidEdit. ALOX5 metabolizes the omega-3 fatty acid, Eicosapentaenoic acid (EPA, i.e. 4Z,8Z,11Z,14Z,17Z- ... Mead acidEdit. Mead acid (i.e. 5Z,8Z,11Z-eicosatrienoic acid) is identical to AA except that has a single rather than double ...
3.0 3.1 3.2 3.3 Tridecanoic acid in Linstrom, P.J.; Mallard, W.G. (eds.) NIST Chemistry WebBook, NIST Standard Reference ... Docosahexaenoic (22:6). *9,12,15,18,21-Tetracosapentaenoic (24:5). *6,9,12,15,18,21-Tetracosahexaenoic (24:6) ... 5.0 5.1 5.2 5.3 Sigma-Aldrich Co., Tridecanoic acid. Retrieved on 2014-06-17. ... "MSDS of n-Tridecanoic acid". http://www.fishersci.ca. Fisher Scientific. ശേഖരിച്ചത് 2014-06-17.. External link in ,website=. ( ...
... profile of common foods; Esterified fatty acids as percentage of total fat[10] Food. Lauric acid. Myristic acid. ... polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol". European Food Safety Authority. ... Some researchers have indicated that serum myristic acid[68][69] and palmitic acid[69] and dietary myristic[70] and palmitic[70 ... Butyric acid with 4 carbon atoms (contained in butter). *Lauric acid with 12 carbon atoms (contained in coconut oil, palm ...
n-Dodecanoic acid, Dodecylic acid, Dodecoic acid, Laurostearic acid, Vulvic acid, 1-Undecanecarboxylic acid, Duodecylic acid, ... Docosahexaenoic (22:6). *9,12,15,18,21-Tetracosapentaenoic (24:5). *6,9,12,15,18,21-Tetracosahexaenoic (24:6) ... 6.0 6.1 6.2 Dodecanoic acid in Linstrom, P.J.; Mallard, W.G. (eds.) NIST Chemistry WebBook, NIST Standard Reference Database ... 2005). Fatty Acids and Atherosclerotic Risk. In Arnold von Eckardstein (Ed.) Atherosclerosis: Diet and Drugs. Springer. pp. 171 ...
CUNNANE, S., PLOURDE, M., STEWART, K., CRAWFORD, M. Docosahexaenoic Acid and Shore-Based Diets in Hominin Encephalization: A ... CARLSON, B. A.; KINGSTON, J. D. Docosahexaenoic acid biosynthesis and dietary contingency: Encephalization without aquatic ... Evidence for the unique function of docosahexanoic acid (DHA) during the evolution of the modern hominid brain. Lipids. 2000, ... CRAWFORD, M. A. Long-Chain Polyunsaturated Fatty Acids in Human Brain Evolution. In: CUNNANE, S.; STEWART, K. Environmental ...
Capric acid[1]. n-Capric acid. n-Decanoic acid. Decylic acid. n-Decylic acid. C10:0 (Lipid numbers) ... కాప్రిక్ ఆమ్లం (Decanoic acid, or capric acid) ఒక సంతృప్త కొవ్వు ఆమ్లం. దీని రసాయన ఫార్ములా : CH3 (CH2) 8COOH. ఈ ఆమ్లపు లవణాలు ...
e.g. docosa-hexaenoic acid (a pejoration of dyoicosa-hexanoic). (e)icosidyakis-. (e)icosidiplo-. (e)icosidyad-. eicostodeutero- ... e.g. eicosapenta-enoic acid. (e)icosipentakis-. (e)icosipentaplo-. (e)icosipentad-. eicostopempto-. - ...
High levels of docosahexaenoic acid (DHA), however, the most abundant omega-3 polyunsaturated fatty acid in erythrocyte (red ... Omega-3 fatty acids have a double bond three carbons away from the methyl carbon, whereas omega-6 fatty acids have a double ... "Omega-3 fatty acids, fish oil, alpha-linolenic acid". Mayo Clinic. 2017. Retrieved 24 May 2017.. ... The illustration below shows the omega-6 fatty acid, linoleic acid. While it is the nutritional aspects of polyunsaturated fats ...
Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence?. Prostaglandins, ... Folic Acid with or without Vitamin B12 for the Prevention and Treatment of Healthy Elderly and Demented people. The Cochrane ... Effect of Folic Acid, with or without other B vitamins, on Cognitive Decline: Meta-analysis of Randomized trials. The American ... Leukotrienes, and Essential Fatty Acids. januar 2013;88(1):61-70. doi:10.1016/j.plefa.2012.04.006. PMID 22575581. ...
... of the stearidonic acid to increase the production of docosahexaenoic acid and the 15-LOX-1 metabolites of docosahexaenoic acid ... Z-octadecadienoic acid, 10-hydroxy-8E,12Z-octadecadienoic acid, and 12-hydroxy-9Z-13-E-octadecadienoic acid.[19] 4- ... linoleic acid, over arachidonic acid, converting it to 13-hydroperoxy-9Z,11E-octadecadienoic acid (13-HpODE).[1][2] The enzyme ... E-octadecadienoic acid, 9-hydroxy-10E,12-Z-octadecadienoic acid, and 11-hydroxy-9Z,12Z-octadecaenoic acid while singlet oxygen ...
"Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans". The American Journal of ...
... under study for possible effects on mood elevation and stabilization include eicosapentaenoic acid and docosahexaenoic acid, ... Fatty acids such as conjugated linoleic acid, catalpic acid, eleostearic acid and punicic acid, in addition to providing energy ... Essential fatty acids[edit]. Main article: Essential fatty acids. Most fatty acids are non-essential, meaning the body can ... As there is no protein or amino acid storage provision, amino acids must be present in the diet. Excess amino acids are ...
... in combination with docosahexaenoic acid (DHA).[13] Mitomycin C worsens post-surgical dry eye.[14] ... Adjuvant polyunsaturated fatty acids (PUFAs) with high Omega-3 content before and after surgery improves sicca, possibly due to ...
... linoleic acid (LA), stearidonic acid (SDA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA). ... Fatty acids[edit]. Plant-based, or vegetarian, sources of Omega 3 fatty acids include soy, walnuts, pumpkin seeds, canola oil, ... Plant foods can provide alpha-linolenic acid which the human body uses to synthesize the long-chain n-3 fatty acids EPA and DHA ... However, certain algae such as spirulina are good sources of gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), ...
Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol). *Unsorted benzodiazepine site positive ... Valproic acid and valnoctamide both inhibit microsomal epoxide hydrolase (MEH), the enzyme responsible for the breakdown of ... and valproic acid.[12] Drugs that decrease the metabolism of carbamazepine or otherwise increase its levels include ... carbamazepine-10,11 epoxide into inactive metabolites.[22] By inhibiting MEH, valproic acid and valnoctamide cause a build-up ...
... or GLA (γ-linolenic acid), (INN and USAN gamolenic acid) is a fatty acid found primarily in seed oils. ... This article is about gamma-Linolenic acid. For α-Linolenic acid, see alpha-Linolenic acid. For linoleic acid (no "n"), see ... It is an isomer of α-linolenic acid, which is a polyunsaturated n−3 (omega-3) fatty acid, found in rapeseed canola oil, ... Although GLA is an n−6 fatty acid, a type of acid that is, in general, pro-inflammatory, it has anti-inflammatory properties. ( ...
"A Long Lipid, a Long Name: Docosahexaenoic Acid". 》The Lipid Chronicles》. ... "Prostaglandins, Leukotrienes, and Essential Fatty Acids》 79 (3-5): 147-52. doi:10.1016/j.plefa.2008.09.008. PMC 2639783. PMID ... Riediger ND, Othman RA, Suh M, Moghadasian MH (April 2009). "A systemic review of the roles of n-3 fatty acids in health and ... Malinauskas T (March 2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". 》Lipids》 43 (3 ...
2005 Hee Young Kim from NIAAA on essentiality of docosahexaenoic acid in the brain ... to the n-6 highly unsaturated fatty acid (n-6HUFA), arachidonic acid (20:4n-6), competitively displaces n-3 HUFA from tissue ... "Prostaglandins Leukot Essent Fatty Acids. 99: 19-23. doi:10.1016/j.plefa.2015.04.005. PMID 26002802.. ... The effect of essential fatty acids on formation of hormones is documented in his book, "Fish, Omega-3 and Human Health" and in ...
2010). «Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys ... Lucas M, Asselin G, Mérette C, Poulin MJ, Dodin S (2009). «Ethyl-eicosapentaenoic acid for the treatment of psychological ...
... and docosahexaenoic acid (DHA). EPA and DHA protect against heart disease and possibly diabetes. The replacement of a ... are the only significant direct dietary sources of two important types of the omega-3 fatty acids called eicosapentaenoic acid ... of the omega-3 fatty acids through a subsistence diet. Tepas, also called stinkheads, stink heads, stinky heads, are fermented ...
... that have been studied most for mood elevation and stabilization include eicosapentaenoic acid and docosahexaenoic acid (each ... The human body contains chemical compounds such as water, carbohydrates, amino acids (found in proteins), fatty acids (found in ... Other essential nutrients not classed as vitamins include essential amino acids (see above), essential fatty acids (see above ... fatty acids) and proteins (amino acids). In the 1860s Claude Bernard discovered that body fat can be synthesized from ...
DHA-clozapine List of omega-3 fatty acids Polyunsaturated fatty acids Guesnet P, Alessandri JM (2011). "Docosahexaenoic acid ( ... 19-hexa-enoic acid, and its shorthand name is 22:6(n−3) in the nomenclature of fatty acids. Most of the docosahexaenoic acid ( ... Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex ... 2007). "Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients ...
... is an omega-3 fatty acid that is important for health. This is a detailed review of DHA and its health effects. ... Docosahexaenoic acid (DHA) is a long-chain omega-3 fatty acid.. Its 22 carbons long, has 6 double bonds and is mainly found in ... Docosahexaenoic acid (DHA) is one of the most important omega-3 fatty acids. ... Technically, it can be synthesized from another plant-based omega-3 fatty acid called alpha-linolenic acid (ALA). However, this ...
Name: Docosahexaenoic acid (DHA) Synonyms: Omega 3 fatty acid. Therapy Type: Supplement, Dietary (timeline). Target Type: Other ... Docosahexaenoic acid (DHA) is one of the most abundant polyunsaturated fatty acids in the human brain. Epidemiological research ... Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the ... A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J ...
... is the main polyunsaturated fatty acid of blood and vascular cells and it has been recognized as the precursor of numerous ... Docosahexaenoic Acid Human Platelet Prostaglandin Endoperoxide Lipoxygenase Product Polyenoic Acid These keywords were added by ... Aveldano, M. and Sprecher, H. Synthesis of hydroxy fatty acids from 4,7,10,13,16,19-[1-14C]-docosahexaenoic acid by human ... In Vitro Studies on Docosahexaenoic Acid in Human Platelets. In: Galli C., Simopoulos A.P. (eds) Dietary ω3 and ω6 Fatty Acids ...
... user ratings and products that contain Docosahexaenoic Acid (Dha) ... Learn more about Docosahexaenoic Acid (Dha) uses, effectiveness ... Fish Oil Fatty Acid, N-3 Fatty Acid, Neuromins, Omega 3, Oméga 3, Omega 3 Fatty Acids, Omega-3 Fatty Acids, W-3 Fatty Acid.,br ... Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable ... Dose-dependent effects of docosahexaenoic acid-rich fish oil on erythrocyte docosahexaenoic acid and blood lipid levels. Br J ...
Docosahexaenoic Acid) uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain ... Fish Oil Fatty Acid, N-3 Fatty Acid, Neuromins, Omega 3, Oméga 3, Omega 3 Fatty Acids, Omega-3 Fatty Acids, W-3 Fatty Acid.,br ... Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable ... Effect of formula supplemented with docosahexaenoic acid and gamma-linolenic acid on fatty acid status and visual acuity in ...
... is one of the beneficial omega-3 fatty acids found most abundantly in fish oils, certain organ meats, and eggs. ... Docosahexaenoic Acid. Docosahexaenoic acid (DHA) is one of the beneficial omega-3 fatty acids found most abundantly in fish ... Among the fatty acids present in the human body, DHA is one of the least saturated and is concentrated in the brain and the ...
It is also the primary dietary source for two n-3 (also called omega-3) long-chain polyunsaturated fatty acids (n-3 PUFA): ... Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An ... eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA is a precursor of DHA and metabolized to DHA in the liver. ... Fish consumption and docosahexaenoic acid (DHA) supplementation in pregnancy. Author. Emily Oken, MD, MPH. Emily Oken, MD, MPH ...
Mechanisms of action of docosahexaenoic acid in the nervous system.. Salem N Jr1, Litman B, Kim HY, Gawrisch K. ... Brief consideration is given to actions of DHA as a nonesterified fatty acid and as a docosanoid or other bioactive molecule. ... Docosahexaenoic Acids/chemistry. *Docosahexaenoic Acids/metabolism*. *Docosahexaenoic Acids/pharmacology*. *Fatty Acids, Omega- ...
... defense and reduces protein nitrosative damage in male ... The aim of this study was to determine the influence of long-term docosahexaenoic acid (DHA) dietary supplementation on the ... Docosahexaenoic acid supplementation promotes erythrocyte antioxidant defense and reduces protein nitrosative damage in male ... Docosahexaenoic acid supplementation promotes erythrocyte antioxidant defense and reduces protein nitrosative damage in male ...
... polyunsaturated fatty acid (PUFA) found in the brain and can affect neurological function by modulating signal transduction ... Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) ... Docosahexaenoic Acid and Cognition throughout the Lifespan by ... Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid (PUFA) found in the brain and can affect ... Weiser, M.J.; Butt, C.M.; Mohajeri, M.H. Docosahexaenoic Acid and Cognition throughout the Lifespan. Nutrients 2016, 8, 99. ...
... a natural fatty acid) and paclitaxel (an anticancer drug) being studied in the treatment of cancer. It is a type of mitotic ... Pentacarboxylic acids and derivatives / N-benzylbenzamides / Beta amino acids and derivatives / Benzoic acid esters / Benzoyl ... A prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti- ... Paclitaxel docosahexaenoic acid. Accession Number. DB05297. Type. Small Molecule. Groups. Investigational. Description. A ...
It represents the extreme example of a class of important human health promoting agents known as omega-3 fatty acids. DHA is ... is the longest and most unsaturated fatty acid commonly found in membranes. ... With 22 carbons and 6 double bonds docosahexaenoic acid (DHA) ... Docosahexaenoic acid affects cell signaling by altering lipid ... With 22 carbons and 6 double bonds docosahexaenoic acid (DHA) is the longest and most unsaturated fatty acid commonly found in ...
Agonist Docosahexaenoic Acid. Clayton Johnson,1,2 Roslyn Williams,3 Jeanne Y. Wei,1 and Gouri Ranganathan1,3 ... R. J. Deckelbaum, T. S. Worgall, and T. Seo, "n-3 fatty acids and gene expression," American Journal of Clinical Nutrition, vol ... R. C. Valentine and D. L. Valentine, "Omega-3 fatty acids in cellular membranes: a unified concept," Progress in Lipid Research ... M. Itoh, T. Suganami, N. Satoh et al., "Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent ...
We have previously demonstrated that docosahexaenoic acid (DHA, 22:6n-3) positively modulates PS biosynthe ... We have previously demonstrated that docosahexaenoic acid (DHA, 22:6n-3) positively modulates PS biosynthesis and accumulation ... Previous Document: Role of liver and plasma lipoproteins in selective transport of n-3 fatty acids to tissues: a compar.... ...
Incorporation of docosahexaenoic acid (DHA) enhances nanodelivery of antiretroviral across the blood-brain barrier for ... we investigated the potential benefits of incorporating docosahexaenoic acid (DHA), an omega-3 fatty acid essential for brain ... Incorporation of docosahexaenoic acid (DHA) enhances nanodelivery of antiretroviral across the blood-brain barrier for ... Incorporation of docosahexaenoic acid (DHA) enhances nanodelivery of antiretroviral across the blood-brain barrier for ...
The omega-3 fatty acid family member docosahexaenoic acid (DHA), which is enriched in these cells, is the precursor of ... Docosahexaenoic Acids / metabolism*. Humans. Nerve Degeneration / metabolism. Oxidative Stress. Photoreceptor Cells / cytology ...
Experimental: Arm I (docosahexaenoic acid) Patients receive docosahexaenoic acid PO BID for 12 weeks. ... Docosahexaenoic Acid in Preventing Recurrence in Breast Cancer Survivors. This study is ongoing, but not recruiting ... I. To determine whether treatment with docosahexaenoic acid (DHA) for 12 weeks at 1000 mg twice daily as compared to placebo ... A Multicenter Phase II Study of Docosahexaenoic Acid (DHA) in Patients With a History of Breast Cancer, Premalignant Lesions, ...
... Nutr Neurosci. 2018 Apr;21(3): ... to date no study exists using low-dose docosahexaenoic acid (DHA) alone as an adjunctive treatment in patients with mild to ... Overview: Whilst the majority of evidence supports the adjunctive use of eicosapentaenoic acid (EPA) in improving mood, ... Docosahexaenoic Acids / administration & dosage * Docosahexaenoic Acids / adverse effects * Docosahexaenoic Acids / therapeutic ...
We hypothesized that maternal supplementation with docosahexaenoic acid (DHA), a PPAR,i,γ,/i, agonist, would normalize IUGR ... such as the long chain fatty acid (FA) docosahexaenoic acid (DHA), improve metabolic disease in both human and animal models ... Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition,. Journal of ... We hypothesized that maternal supplementation with docosahexaenoic acid (DHA), a PPARγ agonist, would normalize IUGR adipose ...
Paula Begoun is the best-selling author of 20 books about skincare and makeup. She is known worldwide as The Cosmetics Cop and creator of Paulas Choice Skincare. Paulas expertise has led to hundreds of appearances on national and international radio, print, and television including:. ...
The DHA (Docosahexaenoic Acid) Oxford Learning and Behaviour (DOLAB) Study (DOLAB). The safety and scientific validity of this ... Dietary Supplement: DHA (docosahexaenoic acid) 3 x 500 mg capsules per day orally, each capsule providing 200 mg of DHA as a ... Dietary Supplement: DHA (docosahexaenoic acid) Dietary Supplement: Sunflower oil capsules Phase 2 ... Richardson AJ, Burton JR, Sewell RP, Spreckelsen TF, Montgomery P. Docosahexaenoic acid for reading, cognition and behavior in ...
Evidence that brain edema and aquaporin-4 (AQP4) water channels have roles in experimental binge ethanol-induced neurodegeneration has stimulated interest in swelling/edema-linked neuroinflammatory pathways leading to oxidative stress. We report here that neurotoxic binge ethanol exposure produces comparable significant effects in vivo and in vitro on adult rat brain levels of AQP4 as well as neuroinflammation-linked enzymes: key phospholipase A2 (PLA2) family members and poly (ADP-ribose) polymerase-1 (PARP-1). In adult male rats, repetitive ethanol intoxication (3 gavages/d for 4 d, ∼9 g/kg/d, achieving blood ethanol levels ∼375 mg/dl;
Docosahexaenoic Acid (DHA) and Infant Vision.. *Dr. Packs Summary #164. *"A Docosahexaenoic Acid-Functional Food During ... the retinal tissues accumulate docosapentaenoic acid from omega-6 fatty acid instead of docosahexaenoic acid. This changes the ... Docosahexaenoic acid (DHA) is a structural component for retinal photoreceptors and brain gray matter. DHA deficiency results ...
Biorganic Omega-3 information about active ingredients, pharmaceutical forms and doses by Gisand, Biorganic Omega-3 indications, usages and related health products lists
Purification and analysis of the factor by mass spectrometry revealed that it is docosahexaenoic acid (DHA), a long-chain ... Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain ... Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain ... Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain ...
Alpha-Linolenic acidArachidonic acidBody mass indexDocosahexaenoic acidDocosapentaenoic acidEicosapentaenoic acidEuropean ... Alzheimers diseaseDietary supplementDocosahexaenoic acidFatty acidFish oilhealthLow-density lipoproteinOmega-3 fatty acid ... Docosahexaenoic acidFish oilNewcastle UniversityOmega-3 fatty acidOrganic milkThe New York TimesUnited KingdomUnited States ... Alzheimers diseaseB vitaminsDocosahexaenoic acidFatty acidfoodLow-density lipoproteinMemory and agingMild cognitive impairment ...
Objective: We tested the hypothesis that 600 mg/d of the omega-3 LCPUFA docosahexaenoic acid (DHA) compared to placebo in ... Background: Long chain polyunsaturated fatty acids (LCPUFAs) have been shown to reduce blood pressure (BP) while they are being ...
Fish intake, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and in some cases alpha-linolenic acid (ALA) have been ... Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD.. ... The association between n-3 fatty acids in plasma lipids and the progression of coronary artery atherosclerosis was assessed ...
Deficiency in docosahexaenoic acid (DHA), a brain-essential omega-3 fatty acid, is associated with cognitive decline. Here we ... A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J. ... Docosahexaenoic acid (DHA), a dietary essential omega-3 fatty acid concentrated in membrane phospholipids at synapses and in ... Cognitive deficits in docosahexaenoic acid-deficient rats. Behav. Neurosci. 2002. 116:1022-1031. View this article via: PubMed ...
  • Arachidonic acid (5,8,11,14-20:4 or 20:4 w 6) is the main polyunsaturated fatty acid of blood and vascular cells and it has been recognized as the precursor of numerous oxygenated derivatives exhibiting a variety of biological activities (1 - 3). (springer.com)
  • Pro-resolution lipid mediators include four classes derived from cell membrane arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid (DHA) which comprise the lipoxins, protectins, resolvins and maresins (MaR) 14 . (nature.com)
  • Tokyo, Japan, Nov 11, 2005 - (JCNN) - Suntory, a leading Japanese beverage manufacturer, announced on November 10 that it has discovered that arachidonic acid and docosahexaenoic acid (DHA) help improve brain functions. (thefreedictionary.com)
  • As such DHA [6] is a key component of neuronal membranes together with arachidonic acid [7] (a major opposing omega-6 fatty acid), making up 15-20% of the brain's dry mass. (glutenfreeworks.com)
  • The primary precursor is arachidonic acid (20:4, n-6), which is enzymatically transformed into inflammatory prostaglandins or leukotrienes that contain two and four double bonds, respectively. (nap.edu)
  • In contrast, combining DHA with n-6 fatty acids, either arachidonic acid or docosapentaenoic acid (DPAn-6), diminished the efficacy of DHA over a 12 month period. (jneurosci.org)
  • DHA-rich diets have been shown to support neurons via healthy gene expression, cell cycle function, and arachidonic acid metabolism. (ovitaminpro.com)
  • We hypothesized that an imbalance between arachidonic acid (AA)- and DHA-derived products could contribute to the chronic pulmonary inflammation observed in CF subjects. (frontiersin.org)
  • FADS1 and FADS2 encode the rate-limiting enzymes responsible for arachidonic acid (ARA) and docosahexaenoic acid (DHA) synthesis. (ku.edu)
  • Others have theorized that phospholipase A2 becomes activated during mild ischemia, arachidonic acid is released, and arachidonic acid cascade modulates cell signaling for protection. (arvojournals.org)
  • Yui K, Koshiba M, Nakamura S, Kobayashim Y, Ohnishi M (2011) Efficacy of Adding Large Doses of Arachidonic Acid to Docosahexaenoic Acid against Restricted Repetitive Behaviors in Individuals with Autism Spectrum Disorders: A Placebo-Controlled Trial. (omicsonline.org)
  • The physiological roles of highly unsaturated fatty acids (HUFA), mainly arachidonic acid (AA, 20:4ω6) and docosahexaenoic acid (DHA, 22:6ω3), are not completely understood. (illinois.edu)
  • Phospholipids in the central nervous system are enriched in n-3 and n-6 polyunsaturated fatty acids (PUFA), especially docosahexaenoic acid (DHA) and arachidonic acid (ARA). (biomedcentral.com)
  • By administering PUFA solutions of DHA, alpha-linolenic acid (ALA, 18:3n-3), arachidonic acid (ARA, 20:4n-6), and linoleic acid (LA, 18:2n-6) directly into the neural tube of in vivo chick embryos, the effects that these different PUFAs have on the NSCs of the neural tube compared to a vehicle control (bovine albumin serum) have been examined. (gvsu.edu)
  • We hypothesized that maternal supplementation with docosahexaenoic acid (DHA), a PPAR γ agonist, would normalize IUGR adipose deposition in association with increased PPAR γ , adiponectin, and adiponectin receptor expression in subcutaneous adipose. (hindawi.com)
  • This study evaluates the effectiveness of maternal supplementation with Docosahexaenoic acid (DHA) early in pregnancy to reduce the incidence of deep placentation disorders: preterm birth, preterm labor, preterm premature rupture of membranes, preeclampsia and fetal growth restriction. (clinicaltrials.gov)
  • Here we show that dietary supplementation with docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, in the 3xTg-AD mouse model of AD reduced the intraneuronal accumulation of both amyloid-β (Aβ) and tau. (jneurosci.org)
  • 2.The effect of supplementation with docosahexaenoic acid (DHA) in (n-3) deficient rats on learning ability was also studied in a model of learning, active avoidance test, after wearing. (nii.ac.jp)
  • Objective To investigate whether dietary supplementation with docosahexaenoic acid (DHA) decreases liver fat content in children with non-alcoholic fatty liver disease (NAFLD). (bmj.com)
  • Lagarde, M. Metabolism of fatty acids by platelets and the functions of various metabolites in mediating platelet function. (springer.com)
  • Croset, M. and Lagarde, M. In vitro incorporation and metabolism of icosapentaenoic and docosahexaenoic acids in human platelets. (springer.com)
  • Weber,P.C. Uptake, release and metabolism of docosahexaenoic acid (DHA, C22:6w3) in human platelets and neutrophils. (springer.com)
  • Limited amounts of eicosapentaenoic and docosapentaenoic acids are possible products of α-linolenic acid metabolism in young women and men. (wikipedia.org)
  • Adiponectin translation is increased by the PPAR γ agonists pioglitazone and ω -3 fatty acids," American Journal of Physiology-Endocrinology and Metabolism , vol. 296, no. 3, pp. (hindawi.com)
  • 4 These differences may play an important role in the utilization and metabolism of the 2 fatty acids. (ahajournals.org)
  • In the present study, the effects of DHA on lipid and fatty acid compositions, and the metabolism of [1-14C]18:3n-3 were investigated in EPC-EFAD cells in comparison with EPC cells. (stir.ac.uk)
  • Understanding how HUFA maintain tissue homeostasis will help in the development of treatments for diseases that result from an altered essential fatty acid metabolism. (illinois.edu)
  • As parameters of lipid metabolism and apparent absorption of DHA-EE, serum and liver lipid contents, fecal EE excretion, lipid-metabolizing enzyme activities, and organ fatty acid composition were measured. (ccsenet.org)
  • Effects of intermittent dietary supplementation with conjugated linoleic acid and fish oil (EPA/DHA) on body metabolism and mitochondrial energetics in mice. (semanticscholar.org)
  • Abstract -Animal studies suggest that the 2 major ω3 fatty acids found in fish, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may have differential effects on blood pressure (BP) and heart rate (HR). The aim of this study was to determine whether there were significant differences in the effects of purified EPA or DHA on ambulatory BP and HR in humans. (ahajournals.org)
  • ABSTRACT: Background: Dietary fatty acids have important homeostatic functions in regulating the immune response and may exert beneficial effects on immune alterations during obesity. (scirp.org)
  • article{d654a6a5-cec8-4cfd-aff5-3485b7f62b71, abstract = {Background There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, could prevent Crohn's disease (CD). (lu.se)
  • Among the fatty acids present in the human body, DHA is one of the least saturated and is concentrated in the brain and the membrane lipids of rods in the eyes. (fsu.edu)
  • A working group from the International Society for the Study of Fatty Acids and Lipids recommended 300 mg/day of DHA for pregnant and lactating women, whereas the average consumption was between 45 mg and 115 mg per day of the women in the study, similar to a Canadian study. (wikipedia.org)
  • The association between n-3 fatty acids in plasma lipids and the progression of coronary artery atherosclerosis was assessed among women with established coronary artery disease (CAD). (nih.gov)
  • Gawrisch, "Mechanisms of action of docosahexaenoic acid in the nervous system," Lipids, vol. (thefreedictionary.com)
  • Dose-Dependent Effects of Docosahexaenoic Acid Supplementation on Blood Lipids in Statin-Treated Hyperlipidaemic Subjects," Lipids 42(2), 109-115 (2007). (thefreedictionary.com)
  • In a previous study, we found that the extent of dietary n -3 docosahexaenoic acid (DHA)-stimulated tissue lipid peroxidation was less than expected from the relative peroxidizability index of the total tissue lipids in rats with adequate vitamin E nutritional status. (cambridge.org)
  • Woodman RJ, Mori TA, Burke V, Puddey IB, Watts GF, Beilin LJ: Effects of purified eicosapentaenoic acid and docosahexaenoic acid on glycemic control, blood pressure and serum lipids in treated-hypertensive type 2 diabetic patients. (diabetesjournals.org)
  • As with most lipid studies, the fatty acid composition of the whole body lipids generally reflected that of the diets. (stir.ac.uk)
  • D6D is a key enzyme in synthesizing HUFA from the precursor dietary essential fatty acids, linoleic acid (LA, 18:2ω6) or α-linolenic acid (ALA, 18:3ω3). (illinois.edu)
  • Although infants can convert shorter-chain n-3 fatty acids to DHA to a greater extent than adults, it is not known whether such conversion is adequate for the developing brain in the absence of adequate maternal DHA intake [ 5-7 ]. (uptodate.com)
  • Fish intake, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and in some cases alpha-linolenic acid (ALA) have been associated with reduced risk of cardiovascular events and death. (nih.gov)
  • The researchers found that an average daily intake of 250 mg of eicosapentaenoic acid and docosahexaenoic acid , which can be gained from eating just one 3-oz portion of farmed salmon or one 6-oz portion of wild salmon per week, was sufficient for optimum protection against heart attacks. (thefreedictionary.com)
  • In the present study, we tested whether elderly with a high dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) would have higher cognitive test scores and greater brain volume than those with low dietary intake of these fatty acids. (springer.com)
  • 2006 ), a low intake of these omega-3 polyunsaturated fatty acids may contribute to cognitive aging in elderly. (springer.com)
  • However, there are also negative findings demonstrating that the dietary intake of omega-3 fatty acids does not affect the rate of cognitive decline and the risk to develop dementia among elderly (Engelhart et al. (springer.com)
  • 2009 ). For instance, in the Rotterdam Study which initially included 5,395 participants (age, ≥55 years) who were free of dementia, a follow-up investigation ten years later revealed that the dietary intake of omega-3 fatty acids did not appear to be associated with long-term dementia risk (Devore et al. (springer.com)
  • To add further support to self-report measures of food intake, the plasma fatty acid composition was also determined. (springer.com)
  • More than 80 percent of dietary polyunsaturated fatty acids consumed in the United States consist of the 18-carbon, 2 double bond, n-6 (18:2, n-6) linoleic acid, with an average intake of about 17 g/day (IOM, 2005). (nap.edu)
  • Background Dietary intake of marine n-3 fatty acids in Japanese in Japan is about 10 times as high as that in the US, e.g. 1.0 g/day vs. 0.1 g/day, respectively. (ahajournals.org)
  • Dietary intake of total n-3 PUFA, including EPA, docosapentaenoic acid (DPA) and DHA, was assessed. (unboundmedicine.com)
  • odds ratios (ORs) were calculated for quintiles of DHA intake, adjusted for total energy intake, smoking, other dietary fatty acids, dietary vitamin D and body mass index. (lu.se)
  • Using plasma phospholipid fatty acid profiles as a biomarker of intake, the authors assessed the validity of an interviewer-administered food frequency questionnaire (FFQ) to estimate intakes of 2 marine-based omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), among 273 community-dwelling adults aged ≥60 years participating in the Nutrition, Aging, and Memory in Elders Study (Boston, Massachusetts, 2002-2008). (pubmedcentralcanada.ca)
  • Intake of alpha-linolenic, but not of docosahexaenoic acid (DHA) correlates positively with DHA content and with parameters for fertilisation potential of human spermatozoa. (ugent.be)
  • Effects of increasing docosahexaenoic acid intake in human healthy volunteers on lymphocyte activation and monocyte apoptosis. (inserm.fr)
  • Beneficial effects of docosahexaenoic acid (DHA) intake in the prevention of cardiovascular diseases are known, and platelets play a crucial role in cardiovascular complications. (inserm.fr)
  • It is also the primary dietary source for two n-3 (also called omega-3) long-chain polyunsaturated fatty acids (n-3 PUFA): eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). (uptodate.com)
  • See 'Long-chain polyunsaturated fatty acids (LCPUFA) for preterm and term infants' . (uptodate.com)
  • Various marine γ-proteobacteria produce ω-3 long chain polyunsaturated fatty acids (PUFAs). (frontiersin.org)
  • Docosahexaenoic acid (DHA) is an essential fatty acid of the family of long chain polyunsaturated fatty acids (LC-PUFAs) or omega-3 fatty acids. (clinicaltrials.gov)
  • Long-chain polyunsaturated fatty acids are important structural components in cell membrane phospholipid bilayers, with EPA and DHA concentrated in synaptic membranes in the brain and in the retina (Dyall and Michael-Titus, 2008). (nap.edu)
  • Long chain polyunsaturated fatty acids play many essential roles in mediating inflammatory reactions, brain myelination, and cognitive function. (nutrition.org)
  • Dietary interventions with long-chain polyunsaturated fatty acids (PUFAs) profoundly influence both physiological processes as well as inflammatory diseases ( 13 , 14 ). (jimmunol.org)
  • Glencross B, Tocher DR, Matthew C & Bell JG (2014) Interactions between dietary docosahexaenoic acid and other long-chain polyunsaturated fatty acids on performance and fatty acid retention in post-smolt Atlantic salmon (Salmo salar), Fish Physiology and Biochemistry, 40 (4), pp. 1213-1227. (stir.ac.uk)
  • An additional treatment with both EPA and DHA included at 5 g kg-1 (total of 10 g kg-1 long-chain polyunsaturated fatty acids, LC-PUFA) was also included. (stir.ac.uk)
  • Betancor M, Howarth FJE, Glencross B & Tocher DR (2014) Influence of dietary docosahexaenoic acid in combination with other long-chain polyunsaturated fatty acids on expression of biosynthesis genes and phospholipid fatty acid compositions in tissues of post-smolt Atlantic salmon (Salmo salar), Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 172-173, pp. 74-89. (stir.ac.uk)
  • Hajarine, M. and Lagarde, M. Studies on polyenoic acid incorporation into human platelet lipid stores:interactions with linoleic and arachidonic acids. (springer.com)
  • Linoleic acid has recently been shown to be glucuronidated in vitro by human liver and intestinal microsomes and recombinant UGT2B7. (aspetjournals.org)
  • No effects of dietary treatment were noted on the retention of either linolenic (18:3n-3) or linoleic (18:2n-6) acids. (stir.ac.uk)
  • 1 Most studies that assessed the potential cardiovascular benefits of ω3 fatty acids have focused largely on the importance of eicosapentaenoic acid (EPA), with little attention given to the relative effect of docosahexaenoic acid (DHA). (ahajournals.org)
  • Effect of docosahexaenoic acid on the senile dementia of dogs. (nii.ac.jp)
  • Soni NK, Ross AB, Scheers N, Savolainen OI, Nookaew I, Gabrielsson BG, Sandberg A-S. Eicosapentaenoic and Docosahexaenoic Acid-Enriched High Fat Diet Delays Skeletal Muscle Degradation in Mice. (mdpi.com)
  • Espinosa A, Valenzuela R, González-Mañán D, D'Espessailles A, Guillermo Gormaz J, Barrera C, Tapia G. Prevention of liver steatosis through fish oil supplementation: correlation of oxidative stress with insulin resistance and liver fatty acid content. (glutenfreeworks.com)
  • In humans, DHA is either obtained from the diet or may be converted in small amounts from eicosapentaenoic acid (EPA, 20:5, ω-3) via docosapentaenoic acid (DPA, 22:5 ω-3) as an intermediate. (wikipedia.org)
  • If the fetus does not get sufficient DHA, the retinal tissues accumulate docosapentaenoic acid from omega-6 fatty acid instead of docosahexaenoic acid. (rainbow.coop)
  • Serum total marine n-3 fatty acids were defined as the sum of EPA, DHA, and docosapentaenoic acid. (ahajournals.org)
  • Docosapentaenoic acid is converted to docosahexaenoic acid in the retinas of normal and prcd-affected miniature poodle dogs. (arvojournals.org)
  • Docosahexaenoic acid (DHA) is the predominant omega-3 ( n -3) polyunsaturated fatty acid (PUFA) found in the brain and can affect neurological function by modulating signal transduction pathways, neurotransmission, neurogenesis, myelination, membrane receptor function, synaptic plasticity, neuroinflammation, membrane integrity and membrane organization. (mdpi.com)
  • Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid (LC-PUFA), highly enriched in the central nervous system, is critical for brain development and function. (pnas.org)
  • The bacterial PUFA biosynthesis system differs from the eukaryotic system wherein PUFAs are produced from a pre-existing fatty acid, e.g., α-linolenic acid [namely (all- Z ) octadeca-9,12,15-trienoic acid], by the alternating actions of multiple elongases and desaturases ( Metherel and Bazinet, 2019 ). (frontiersin.org)
  • Docosahexanoic acid (DHA) is an omega n-3 polyunsaturated fatty acid (PUFA) found in fish and certain algae. (jneurosci.org)
  • Resolution of inflammation in the periphery was once thought to be a passive process, but new research now suggests it is an active process mediated by specialized pro-resolving lipid mediators (SPM) derived from omega-3 polyunsaturated fatty acids (n-3 PUFA). (ovid.com)
  • n -3 Polyunsaturated fatty acids ( n -3 PUFA) have been recognized to have anticancer properties for over 20 years. (aacrjournals.org)
  • 20:5n-3), total n-3 polyunsaturated fatty acids (PUFA), total PUFA and saturated fatty acids in total lipid and total polar lipid in both cell lines. (stir.ac.uk)
  • Docosahexaenoic acid (DHA, 22:6n-3) must be consumed in the diet or synthesized from n-3 polyunsaturated fatty acid (PUFA) precursors. (uwaterloo.ca)
  • However, there were notable exceptions to this, and these implicate some interactions among the different LC-PUFA in terms of the fatty acid bio- chemistry in this species. (stir.ac.uk)
  • The liver, brain, head kidney and gill were collected at the conclusion of the trial, and lipid and fatty acid compositions were determined as well as expression of genes of LC-PUFA biosynthesis. (stir.ac.uk)
  • The brain showed the most conserved composition and gene expression profile, with increased dietary LC-PUFA resulting in only minor changes in PL fatty acids. (stir.ac.uk)
  • Dietary LC-PUFA significantly affected the expression of Δ6 and Δ5 desaturases, Elovl 2, 4 and 5, and SREBPs although this varied between tissues with greatest effects observed in the liver followed by the head kidney, similar to PL fatty acid compositions. (stir.ac.uk)
  • Docosahexaenoic acid (DHA, 22:6n-3), a predominant, omega-3 (n-3) structural polyunsaturated fatty acid (PUFA) in the brain, has been shown to play an important role in the development and function of neural cells, and is obtained from dietary sources. (gvsu.edu)
  • Ahmed, A.A. and Holub, B.J. Alterations and recovery of bleeding times, platelet aggregation and fatty acid composition of individual phospholipids in platelets of human subjects receiving a supplement of cod liver oil. (springer.com)
  • DHA is a major fatty acid in brain phospholipids and the retina. (wikipedia.org)
  • There is some potential storage of these acids in the phospholipids of muscle tissue and adipose tissue. (cabi.org)
  • The present paper describes an alterative cholinergic strategy to memory enhancement by the exogenous introduction of highly enriched docosahexaenoic acid (DHA) - containing molecular species of highly pure phospholipids and highly pure ether phospholipids based brain DHA transporters to promote survival of aged basal forebrain cholinergic neurons (BFCNs) through reversing abnormal levels of neural membrane DHA aminophospholipids. (eurekaselect.com)
  • The peroxidative stability of docosahexaenoic acid (DHA)-containing oils (DHA at 10.7 mol% of the total fatty acids), in the form of phospholipids (PL), triacylglycerols (TG), and ethyl esters (EE) with the same constituent fatty acids, was investigated in the dark at 25°C in a bulk phase, and compared with that of control palm oil (supplemented with 20% soybean oil). (go.jp)
  • In fact, DHA makes up over 90% of the omega-3 fatty acids in your brain and up to 25% of its total fat content ( 3 , 5 ). (healthline.com)
  • DHA is an omega-3 fatty acid that is vital for your skin, eyes and brain. (healthline.com)
  • Brain levels of other omega-3 fatty acids , such as EPA, are typically 250-300 times lower ( 3 , 4 , 18 ). (healthline.com)
  • Docosahexaenoic acid (DHA) is one of the most abundant polyunsaturated fatty acids in the human brain. (alzforum.org)
  • Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. (wikipedia.org)
  • DHA is the most abundant omega-3 fatty acid in the brain and retina. (wikipedia.org)
  • DHA comprises 40% of the polyunsaturated fatty acids (PUFAs) in the brain and 60% of the PUFAs in the retina. (wikipedia.org)
  • A major structural component of the mammalian central nervous system, DHA is the most abundant omega−3 fatty acid in the brain and retina. (wikipedia.org)
  • Incorporation of docosahexaenoic acid (DHA) enhances nanodelivery of antiretroviral across the blood-brain barrier for treatment of HIV reservoir in brain. (greenmedinfo.com)
  • In this study, we investigated the potential benefits of incorporating docosahexaenoic acid (DHA), an omega-3 fatty acid essential for brain development, in lipid nanocarriers for facilitating the BBB passage of an ARV darunavir. (greenmedinfo.com)
  • Docosahexaenoic acid (DHA) is a structural component for retinal photoreceptors and brain gray matter. (rainbow.coop)
  • Purification and analysis of the factor by mass spectrometry revealed that it is docosahexaenoic acid (DHA), a long-chain polyunsaturated fatty acid that is highly enriched in the adult mammalian brain. (sciencemag.org)
  • DHA, found in fish oil, is an essential omega-3 fatty acid and is vital for proper brain function. (qualitycounts.com)
  • Odwalla Inc., Half Moon Bay, Calif., launches three flavors of Odwalla Soymilk, combining organic soybeans, soluble fiber inulin and Martek Biosciences' docosahexaenoic acid (DHA), a proprietary vegetarian source of this important brain nutrient. (thefreedictionary.com)
  • D ocosahexaenoic acid ( DHA [6] ) is an essential omega-3 fatty acid that is abundant in the brain, being crucial in brain structure. (glutenfreeworks.com)
  • Brain arachidonic and docosahexaenoic acid [6] cascades are selectively altered by drugs, diet and disease. (glutenfreeworks.com)
  • There are various models that explain the transportation of fatty acids through the blood-brain barrier, most of them involving complexes with albumin and circulating lipoproteins. (nap.edu)
  • Because DHA makes up such a large proportion of the fatty acids in the brain, and plays roles in neuronal excitability, it is possible that DHA reduction contributes to memory impairments in AD. (jneurosci.org)
  • DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) work to support the brain by promoting better cognitive functioning. (ovitaminpro.com)
  • Brain and lung expression of fatty acid transporters were measured in offspring from dams consuming a diet containing 10% corn oil. (nutrition.org)
  • Both genotypes had increasing concentrations of DHA in the brain from day 3 to 28 in the face of decreasing expression of fatty acid transporters. (nutrition.org)
  • Importantly, the concentrations of DHA in the brain appears to be diet-dependent, and independent of fatty acid transporter expression. (nutrition.org)
  • In a commentary on this article , Mazzocchi and Agostoni, agree that the data presented by Yakah and colleagues indicate that diet may be the major determinant of w-3 long chain fatty acids in the brain throughout development. (nutrition.org)
  • Developmental accretion of docosahexaenoic acid is independent of fatty acid transporter expression in brain and lung tissues of C57BL/6 and Fat1 mice. (nutrition.org)
  • Because critical tissues levels, such as those in the brain, appear to be dependent on diet content of the preformed long chain w-3 fatty acids, Mazzocchi and Agostoni suggest the need for further work to focus on digestion and absorption of these fatty acids, and determine whether there may be temporal differences in those processes. (nutrition.org)
  • The purpose of this study was to measure resolution of neuroinflammation and to test whether increasing brain docosahexaenoic acid (DHA) affects the resolution of neuroinflammation. (ovid.com)
  • Increased brain docosahexaenoic acid did not increase resolution of neuroinflammation. (ovid.com)
  • The polyunsaturated fatty acids, arachidonicacid (ARA) and docosahexaenoic acid (DHA) play key roles in the maturation of the brain network. (omicsonline.org)
  • GROUND: Docosahexaenoic acid (DHA), present in high concentrations in the brain and retina, has a role in visual development. (experts123.com)
  • This investigation was carried out to examine the characteristic changes in aged dogs, and the physiological role of docosahexaenoic acid to brain function in animal models. (nii.ac.jp)
  • These results suggest that chronic consumption of a (n-3) fatty acid deficient diet could modify the biosynthesis of catecholamine in the brain, and might induce the behavioral disturbances. (nii.ac.jp)
  • Docosahexaenoic acid (DHA) is an omega-3 (ω-3) long-chain polyunsaturated fatty acid (LCPUFA) relevant for brain function. (biomedcentral.com)
  • Omega-3 fatty acids are crucial to the proper development and function of cell membranes in the brain. (coping-with-epilepsy.com)
  • By determining a deficiency in the red blood cell membranes in these patients, we infer that brain cell membranes are also depleted of this normal fatty acid,' says Dr. Henry. (coping-with-epilepsy.com)
  • In humans, these fatty acids can be produced by enzymatic elongation and desaturation of their precursor α-linolenic acid (ALA, C18:3n-3). (springer.com)
  • The results of this study suggest that DHA is the principal ω3 fatty acid in fish and fish oils that is responsible for their BP- and HR-lowering effects in humans. (ahajournals.org)
  • Fish oil supplementation in humans results in substantial increases in plasma and tissue ω3 fatty acids, particularly EPA and DHA, but with variable incorporation in different phospholipid classes in different tissues. (ahajournals.org)
  • Mori TA, Bao DQ, Burke V, Puddey IB, Beilin LJ: Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. (diabetesjournals.org)
  • This study demonstrated that butyrate and docosahexaenoic acid have antifibrogenic effects on keloid fibroblasts and that these may exert therapeutic effects for keloid. (sigmaaldrich.com)
  • The therapeutic efficacy of individual components of fish oils (FOs) in various human inflammatory diseases still remains unresolved, possibly due to low levels of n-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or lower ratio of DHA to EPA. (jimmunol.org)
  • Docosahexaenoic acid (DHA) enhances the therapeutic potential of neonatal neural stem cell. (deepdyve.com)
  • DHA can be metabolized into DHA-derived specialized pro-resolving mediators (SPMs), DHA epoxides, electrophilic oxo-derivatives (EFOX) of DHA, neuroprostanes, ethanolamines, acylglycerols, docosahexaenoyl amides of amino acids or neurotransmitters, and branched DHA esters of hydroxy fatty acids, among others. (wikipedia.org)
  • Objective: We tested the hypothesis that 600 mg/d of the omega-3 LCPUFA docosahexaenoic acid (DHA) compared to placebo in pregnancy can reduce offspring BP at 7 and 8 years of age. (ku.edu)
  • Docosahexaenoic acid (DHA), an omega-3 (ω-3) long-chain polyunsaturated fatty acid (LCPUFA), is involved in a wide range of cellular processes in mammalian cells. (biomedcentral.com)
  • I. To determine whether treatment with docosahexaenoic acid (DHA) for 12 weeks at 1000 mg twice daily as compared to placebo reduces normal breast tissue levels of tumor necrosis factor-alpha (TNF-alpha) in overweight and obese patients with a history of stage I-III invasive breast cancer, ductal carcinoma in situ (DCIS), Paget's disease, lobular carcinoma in situ (LCIS), or proliferative benign breast disease. (clinicaltrials.gov)
  • PARIS -- Children whose mothers received docosahexaenoic acid supplements for 4 months post partum performed better on standardized tests of sustained attention at 5 years of age compared with those whose mothers received placebo, Craig Jensen, M.D., said at the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. (thefreedictionary.com)
  • Methodology: investigators will conduct a randomized, placebo controlled, double blind, clinical trial of maternal supplementation with DHA (Docosahexaenoic acid) to prevent deep placentation disorders. (clinicaltrials.gov)
  • Moreover, based on the results predicted by the model, six amino acids were shown to improve DHA production by experiment. (biomedcentral.com)
  • The reconstructed GSMM, i CY1170_DHA, could be used to elucidate the mechanism by which DHA is synthesized in S. limacinum and predict the requirements of abundant acetyl-CoA and NADPH for DHA production as well as the enhanced yields achieved via supplementation with six amino acids, malate, and citrate. (biomedcentral.com)
  • The omega-3 fatty acid family member docosahexaenoic acid (DHA), which is enriched in these cells, is the precursor of neuroprotectin D1 (NPD1). (biomedsearch.com)
  • Polyunsaturated fatty acids serve as the precursor molecules for eicosanoids. (nap.edu)
  • Several reports have indicated the presence of specific fatty acid (FA) alterations in CF patients, most notably decreased levels of plasmatic and tissue docosahexaenoic acid (DHA), the precursor of Specialized Pro-resolving Mediators (SPMs). (frontiersin.org)
  • A Docosahexaenoic Acid-Functional Food During Pregnancy Benefits Infant Visual Acuity at Four but not Six Months of Age. (rainbow.coop)
  • Hypothesis: investigators propose that Docosahexaenoic acid (DHA) supplementation, early in pregnancy, reduces the incidence of deep placentation disorders (preterm birth, preterm labor, preterm premature rupture of membranes, preeclampsia and fetal growth restriction), by improving deep placentation physiology: invasion and transformation of spiral arteries by trophoblast. (clinicaltrials.gov)
  • The major purpose of this study is to examine the effect of two sources of dietary omega-3 fatty acids, each given at two doses, on potential health benefits related to cardiovascular dise. (bioportfolio.com)
  • Current evidence from epidemiological studies, clinical trials, and experimental animal studies suggests that ω3 fatty acids of marine origin may be protective against cardiovascular disease. (ahajournals.org)
  • Methods A population-based sample of 940 randomly selected Japanese men aged 40-79 years without clinical cardiovascular disease from Kusatsu, Shiga, Japan, were examined for CAC, cardiovascular risk factors and serum fatty acids including eicosapentaenoic (EPA) and docosaxehaenoic acids (DHA) during 2005 to 2008. (ahajournals.org)
  • Large-scale epidemiologic studies and randomised controlled trials provided evidence that ω-3 fatty acids (eicosapentaenoic acid, docosahexaenoic acid (DHA) and α-linolenic acid) significantly reduce the occurrence of cardiovascular disease events in patients with coronary artery disease [ 13 ]. (ersjournals.com)
  • Omega-3 fatty acids, in particular docosahexaenoic acid (DHA), have been extensively studied for many decades for their health benefitting properties in pre-natal development, cardiovascular and Alzheimer diseases and enhancing the inflammatory immune response system. (bl.uk)
  • Recent literature data suggest beneficial effects of dietary fats in patients with cancers, in particular polyunsaturated fatty acids (PUFAs). (bioportfolio.com)
  • Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which belong to the same class of long chain ω-3 polyunsaturated fatty acids (PUFAs), are present in marine γ-proteobacteria. (frontiersin.org)
  • Human tumor cells differ in their sensitivity to n -3 PUFAs, which cannot be explained simply by differences in fatty acid uptake ( 13 ) but may be related to the level of expression of antioxidant enzymes ( 14 ). (aacrjournals.org)
  • Early evidence suggests that dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve mitochondrial function. (semanticscholar.org)
  • Omega−3 fatty acids, also called Omega-3 oils, ω−3 fatty acids or n−3 fatty acids, are polyunsaturated fatty acids (PUFAs) characterized by the presence of a double bond, three atoms away from the terminal methyl group in their chemical structure. (wikipedia.org)
  • Technically, it can be synthesized from another plant-based omega-3 fatty acid called alpha-linolenic acid (ALA). However, this process is very inefficient, and only 0.1-0.5% of ALA is converted into DHA in your body ( 6 , 7 , 8 , 9 , 10 ). (healthline.com)
  • It can be synthesized from alpha-linolenic acid or obtained directly from maternal milk (breast milk), fish oil, or algae oil. (wikipedia.org)
  • The major dietary n-3 fatty acid is alpha-linolenic acid (ALA) (18:3, n-3), which is derived from certain nuts and vegetable oils (Kris-Etherton et al. (nap.edu)
  • 7R,14S-dihydroxy-docosa-4Z,8E,10E,12Z,16Z,19Z-hexaenoic acid) is a pro-resolution lipid mediator derived from the docosahexaenoic acid, which presents anti-inflammatory and pro-resolution effects. (nature.com)
  • Butyrate, a short-chain fatty acid, and docosahexaenoic acid (DHA), a ω-3 polyunsaturated fatty acid, play multiple anti-inflammatory and anticancer roles via their respective mechanisms of action. (sigmaaldrich.com)
  • The ω-3 (n-3) FAs eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) exert anti-inflammatory effects in various diseases, including inflammatory bowel disease and rheumatoid arthritis ( 13 ). (jimmunol.org)
  • Levels of conjugated diene, chemiluminescence emission and thiobarbituric acid (TBA)-reactive substance in the liver, kidney, and testis were determined as indicators of lipid peroxidation. (cambridge.org)
  • Lipid peroxidation was greater following DHA treatment of the sensitive DHL-4 cells than in the resistant SiHa cells, as assessed by thiobarbituric acid reactive substance generation. (aacrjournals.org)
  • We have investigated if glaucoma patients have abnormal blood fatty acid composition. (unboundmedicine.com)
  • Using omega 3 fatty acids to treat Alzheimer's and other diseases? (qualitycounts.com)
  • Docosahexaenoic acid ( DHA ) is one of the beneficial omega-3 fatty acids found most abundantly in fish oils, certain organ meats, and eggs. (fsu.edu)
  • Research by Efamol into fatty acid-based supplements found low levels of these nutrients, in particular docosahexaenoic acid (DHA), can be a factor in illnesses like depression. (thefreedictionary.com)
  • Liu, J. Physiological and Biochemical Changes Reveal Differential Patterns of Docosahexaenoic Acid Partitioning in Two Marine Algal Strains of Isochrysis . (mdpi.com)
  • We have previously demonstrated that docosahexaenoic acid (DHA, 22:6n-3) positively modulates PS biosynthesis and accumulation in neuronal cells, promoting survival. (biomedsearch.com)
  • Dietary docosahexaenoic acid (DHA) modulates atherosclerosis and hypertension, possibly via an inflammatory mechanism. (whiterose.ac.uk)
  • Koelsch, Jenna, "The Effects of the Common Prenatal Supplement Docosahexaenoic Acid on Neurogenesis in the Developing Embryo" (2016). (gvsu.edu)
  • Sixty percent of the fatty acids that make up neuronal cell membranes consist of DHA, and it is particularly concentrated in synaptic membranes ( Bazan and Scott, 1990 ) and in myelin sheaths ( Ansari and Shoeman, 1990 ). (jneurosci.org)
  • This fraction is not a good substrate for lipoprotein lipase, which is the enzyme in the mammary gland that removes fatty acids from the circulation for incorporation into milk fat. (cabi.org)
  • DHL-4 cells treated with DHA for 20 hours showed a 3.5-fold increase in thiobarbituric acid reactive substances, whereas SiHa cells showed no increase. (aacrjournals.org)
  • Neuronal specific increase of phosphatidylserine by docosahexaenoic acid. (biomedsearch.com)
  • It is possible that the EPA and DHA present in the milk arise from de novo synthesis of these acids from LNA in the mammary gland. (cabi.org)
  • After the feeding period, 2H5-ALA and 13C20-eicosapentaenoic acid (EPA, 20:5n-3) were co-infused and blood was collected over 3 h for determination of whole-body synthesis-secretion kinetics. (uwaterloo.ca)
  • Similarly to conventional fatty acid synthesis, the biosynthesis of DHA via PKS requires abundant acetyl-CoA and NADPH. (biomedcentral.com)
  • Effects of docosahexaenoic acid on some megakaryocytic cell gene expression of some enzymes controlling prostanoid synthesis. (inserm.fr)
  • Docosahexaenoic acid (DHA) is a long-chain omega-3 fatty acid. (healthline.com)
  • Croset, M., Guichardant, M. and Lagarde, M. Different metabolic behavior of long chain n-3 polyunsaturated fatty acids in human platelets. (springer.com)
  • PPAR γ agonists, such as the long chain fatty acid (FA) docosahexaenoic acid (DHA), improve metabolic disease in both human and animal models and increase PPAR γ mediated transcription of targets such as adiponectin [ 11 , 13 , 14 ]. (hindawi.com)
  • We recently reported that both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the two major dietary long-chain n-3 fatty acids, significantly reduced triglycerides and increased HDL 2 cholesterol without changing total, LDL, or HDL cholesterol in a group of type 2 diabetic subjects ( 1 ). (diabetesjournals.org)
  • 2000). Although the long-chain n-3 fatty acids eicosapentaenoic acid (EPA) (20:5, n-3) and docosahexaenoic acid (DHA) (22:6, n-3) can be synthesized from linolenic acid, the efficiency (yield) of the enzymatic reactions involved is rather low (Jones and Kubow, 2006). (nap.edu)
  • Mazzocchi A, Agostoni C. Long-chain w-3 polyunsaturated fatty acids: Do genetic steps match metabolic needs? (nutrition.org)
  • Issues related to the health effects of fish and these supplements in the general population are reviewed separately (see 'Fish oil and marine omega-3 fatty acids' ). (uptodate.com)
  • The company produces life'sDHA, a sustainable and vegetarian source of the omega-3 fatty acid DHA ( docosahexaenoic acid ), for use in foods, beverages, infant formula, and supplements. (thefreedictionary.com)
  • In people with advanced cancer and cachexia, omega−3 fatty acids supplements may be of benefit, improving appetite, weight, and quality of life. (wikipedia.org)
  • Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells" Neuroscience, vol. (thefreedictionary.com)
  • Schizochytrium limacinum SR21 is a potential industrial strain for docosahexaenoic acid (DHA) production that contains more than 30-40 % DHA among its total fatty acids. (biomedcentral.com)
  • The dry cell weight, lipid content, and DHA percentage of the total fatty acids are three important parameters for evaluating fermentations. (biomedcentral.com)
  • Dyerberg, J. Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. (springer.com)
  • Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD. (nih.gov)
  • Omega-3 fatty acids found in fish oil have some smaller components: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). (thefreedictionary.com)
  • Importantly, n-3 polyunsaturated fatty acids selectively inhibit tumor cell proliferation and are significantly less toxic towards normal cells ( 21 , 22 ). (aacrjournals.org)
  • We recently reported that daily fish meals that provide 3.65 g/d of ω3 fatty acids significantly reduced blood pressure (BP) in overweight, treated hypertensives. (ahajournals.org)
  • We have previously reported that serum levels of marine n-3 fatty acids were modestly and non-significantly associated with coronary artery calcification (CAC) among Japanese men aged 40-49 years. (ahajournals.org)
  • After DHA supplementation, not only DHA/AA ratio and highly unsaturated fatty acid (HUFA) index were significantly increased (p (frontiersin.org)
  • In both tissues increasing dietary DHA led to significantly increased DHA in PL and inclusion of EPA or ARA led to higher levels of these fatty acids. (stir.ac.uk)
  • Docosahexaenoic acid (DHA) is one of the most important omega-3 fatty acids . (healthline.com)
  • What's more, the conversion also relies on adequate levels of other vitamins and minerals, as well as the amount of omega-6 fatty acids in your diet ( 11 , 12 , 13 ). (healthline.com)
  • These are being marketed in different formulations of DHA, or DHA mixed with other omega-3 fatty acids such as eicosapentaenoic acid (EPA). (alzforum.org)
  • DHA (docosahexaenoic acid) is an omega-3 fatty acid. (webmd.com)
  • In organisms that do not eat algae containing DHA nor animal products containing DHA, DHA is instead produced internally from α-linolenic acid, a shorter omega-3 fatty acid manufactured by plants (and also occurring in animal products as obtained from plants). (wikipedia.org)
  • Foods high in omega-3 fatty acids may be recommended to women who want to become pregnant or when nursing. (wikipedia.org)
  • A prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. (drugbank.ca)
  • It represents the extreme example of a class of important human health promoting agents known as omega-3 fatty acids. (nih.gov)
  • Science Daily, 7/18/17 - 'Docosahexaenoic acid (DHA), a key essential Omega-3 fatty acid, produces signaling molecules called docosanoids in response to disruptions in the state of equilibrium within cells caused by injury or disease. (qualitycounts.com)
  • Eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), also known as omega-3 fatty acids, are polyunsaturated fatty acids that are mainly found in fish and food of marine origin. (springer.com)
  • The importance of omega-3 fatty acids for behavior, cognition, and mood. (glutenfreeworks.com)
  • Polyunsaturated fatty acids are classified as n-3 (omega-3) or n-6 (omega-6) depending on whether their first double bond is located on the third or sixth carbon from the terminal methyl group (Jones and Kubow, 2006). (nap.edu)
  • Omega-3 fatty acids are essential to the overall health of people of all ages. (ovitaminpro.com)
  • DHA Ultimate is an omega-3 essential fatty acid dietary supplement that supports neural and cognitive function. (ovitaminpro.com)
  • The omega-3 essential fatty acid DHA is well recognized for its ability to support neural and cognitive function. (ovitaminpro.com)
  • Learning and memory depend on dendritic spine actin assembly and docosahexaenoic acid (DHA), an essential n-3 (omega-3) polyunsaturated fatty acid (PFA). (pubmedcentralcanada.ca)
  • However, due to fish oil and fish meal supplies currently facing many challenges (e.g. heavy metal contamination, environmental impacts, etc.), the demand for alternative sources of omega-3 fatty acids (FA) is predicted to rise in the near future. (bl.uk)
  • Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation? (semanticscholar.org)
  • The three types of omega−3 fatty acids involved in human physiology are α-linolenic acid (ALA), found in plant oils, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both commonly found in marine oils. (wikipedia.org)
  • Marine algae and phytoplankton are primary sources of omega−3 fatty acids. (wikipedia.org)
  • Mammals are unable to synthesize the essential omega−3 fatty acid ALA and can only obtain it through diet. (wikipedia.org)
  • The ability to make the longer-chain omega−3 fatty acids from ALA may be impaired in aging. (wikipedia.org)
  • Dietary supplementation with omega−3 fatty acids does not appear to affect the risk of death, cancer or heart disease. (wikipedia.org)
  • The terms ω-3 ("omega-3") fatty acid and n-3 fatty acid are derived from organic nomenclature. (wikipedia.org)
  • Thus, in omega-3 fatty acids in particular, there is a double bond located at the carbon numbered 3, starting from the methyl end of the fatty acid chain. (wikipedia.org)
  • For instance, in an omega-3 fatty acid with 18 carbon atoms (see illustration), where the methyl end is at location 18 from the carboxyl end, n (or ω) represents the number 18, and the notation n-3 (or ω-3) represents the subtraction 18-3 = 15, where 15 is the locant of the double bond which is closest to the methyl end, counted from the carboxyl end of the chain. (wikipedia.org)
  • Although n and ω (omega) are synonymous, the IUPAC recommends that n be used to identify the highest carbon number of a fatty acid. (wikipedia.org)
  • Nevertheless, the more common name - omega-3 fatty acid - is used in both the lay media and scientific literature. (wikipedia.org)
  • Hence, it is an omega-3 fatty acid. (wikipedia.org)
  • With the possible exception of breast cancer, there is insufficient evidence that supplementation with omega−3 fatty acids has an effect on different cancers. (wikipedia.org)
  • Dietary strategies for increasing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) concentrations in bovine milk: a review. (cabi.org)
  • Samples were collected from the pups at days 3, 14 and 28 to determine gene expression and fatty acid concentrations. (nutrition.org)
  • Lung concentrations of DHA were not different at the 3 time points for both genotypes, even though the expression of some fatty acid transporters were elevated in the mice. (nutrition.org)
  • As compared to COPD patients, CF subjects showed increased concentrations of leukotriene B4 (LTB4), prostaglandin E2 (PGE2), and 15-hydroxyeicosatetraenoic acid (15-HETE), while the concentrations of DHA metabolites were not different in the two groups. (frontiersin.org)
  • DHA is an unsaturated fatty acid with 6 double bonds. (healthline.com)
  • With 22 carbons and 6 double bonds docosahexaenoic acid (DHA) is the longest and most unsaturated fatty acid commonly found in membranes. (nih.gov)
  • Prostaglandins and leukotrienes synthesized from n-3 fatty acids contain three and five double bonds, respectively, and are less biologically active (Jones and Kubow, 2006). (nap.edu)
  • illustration) is an 18-carbon chain having three double bonds, the first being located at the third carbon from the methyl end of the fatty acid chain. (wikipedia.org)
  • α-Linolenic acid is polyunsaturated (containing more than one double bond) and is also described by a lipid number, 18:3, meaning that there are 18 carbon atoms and 3 double bonds. (wikipedia.org)
  • Peroxisome assembly disorders are genetic disorders characterized by biochemical abnormalities, including low docosahexaenoic acid (DHA). (kennedykrieger.org)
  • In the present study, the dietary fatty acids (FA), phytanic acid (PA), and docosahexaenoic acid (DHA) have been used as substrates for human UDP-glucuronosyltransferases (UGTs). (aspetjournals.org)
  • There were no associations with the other dietary fatty acids studied. (lu.se)