A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.
Contractile activity of the MYOCARDIUM.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Drugs that selectively bind to and activate beta-adrenergic receptors.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
Compounds that bind to and activate ADRENERGIC BETA-1 RECEPTORS.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Compounds of the general formula R:N.NR2, as resulting from the action of hydrazines with aldehydes or ketones. (Grant & Hackh's Chemical Dictionary, 5th ed)
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The circulation of blood through the CORONARY VESSELS of the HEART.
The hollow, muscular organ that maintains the circulation of the blood.
The span of viability of a tissue or an organ.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Period of contraction of the HEART, especially of the HEART VENTRICLES.
AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Drugs used to cause dilation of the blood vessels.
Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.
The period of history from 1451 through 1600 of the common era.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.

Reversal of severe pulmonary hypertension with beta blockade in a patient with end stage left ventricular failure. (1/1123)

A 52 year old man with severe chronic left ventricular failure (New York Heart Association class IV) was considered unsuitable for cardiac transplantation because of high and irreversible pulmonary vascular resistance (PVR). In an attempt to produce symptomatic improvement, metoprolol was cautiously introduced, initially at 6.25 mg twice daily. This was slowly increased to 50 mg twice daily over a two month period and continued thereafter. After four months of treatment the patient's symptoms had improved dramatically. His exercise tolerance had increased and diuretic requirements reduced to frusemide 160 mg/day only. Assessment of right heart pressures was repeated and, other than a drop in resting heart rate, there was little change in his pulmonary artery pressure or PVR. His right heart pressures were reassessed showing a pronounced reduction in pulmonary artery pressure and a significant reduction in PVR, which fell further with inhaled oxygen and sublingual nitrates. He was then accepted onto the active waiting list for cardiac transplantation. A possible mechanism of action was investigated by assessing responses to beta agonists during treatment. Not only was there pronounced improvement in PVR but it was also demonstrated that beta receptor subtype cross-regulation may have contributed to the mechanism of benefit.  (+info)

Recovery of contractility of viable myocardium during inotropic stimulation is not dependent on an increase of myocardial blood flow in the absence of collateral filling. (2/1123)

OBJECTIVES: The purpose of this study was to determine whether contractile recovery induced by dobutamine in dysfunctioning viable myocardium supplied by nearly occluded vessels is related to an increase in blood flow in the absence of collaterals. BACKGROUND: Dobutamine is used to improve contractility in ventricular dysfunction during acute myocardial infarction. However, it is unclear whether a significant increase in regional blood flow may be involved in dobutamine effect. METHODS: Twenty patients with 5- to 10-day old anterior infarction and > or =90% left anterior descending coronary artery stenosis underwent 99mTc-Sestamibi tomography (to assess myocardial perfusion) at rest and during low dose (5 to 10 microg/kg/min) dobutamine echocardiography. Rest echocardiography and scintigraphy were repeated >1 month after revascularization. Nine patients had collaterals to the infarcted territory (group A), and 11 did not (group B). RESULTS: Baseline wall motion score was similar in both groups (score 15.9+/-1.3 vs. 17.4+/-2.0, p = NS), whereas significant changes at dobutamine and postrevascularization studies were detected (F[2,30] = 409.79, p < 0.0001). Wall motion score improved significantly (p < 0.001) in group A both at dobutamine (-5.3+/-2.2) and at postrevascularization study (-5.5+/-1.9), as well as in group B (-3.9+/-2.8 and -4.5+/-2.4, respectively). Baseline 99mTc-Sestamibi uptake was similar in both groups (62.9+/-9.7% vs. 60.3+/-10.4%, p = NS), whereas at dobutamine and postrevascularization studies a significant change (F[2,30] = 65.17, p < 0.0001) and interaction between the two groups (F[2,30] = 33.14, p < 0.0001) were present. Tracer uptake increased significantly in group A both at dobutamine (+ 10.9+/-7.9%, p < 0.001) and at postrevascularization study (12.1+/-8.7%, p < 0.001). Conversely, group B patients showed no change in tracer uptake after dobutamine test (-0.4+/-5.8, p = NS), but only after revascularization (+8.8+/-7.2%, p < 0.001). CONCLUSIONS: The increase in contractility induced by low dose dobutamine infusion in dysfunctional viable myocardium supplied by nearly occluded vessels occurs even in the absence of a significant increase in blood flow.  (+info)

Prognostic value of dobutamine stress echocardiography in predicting cardiac events in patients with known or suspected coronary artery disease. (3/1123)

OBJECTIVES: The study sought to determine the utility of dobutamine stress echocardiography (DSE) in predicting cardiac events in the year after testing. BACKGROUND: Increasingly, DSE has been applied to risk stratification of patients. METHODS: Medical records of 1,183 consecutive patients who underwent DSE were reviewed. The cardiac events that occurred during the 12 months after DSE were tabulated: myocardial infarction (MI), cardiac death, percutaneous transluminal coronary angioplasty (PTCA), and coronary artery bypass surgery (CABG). Patient exclusions included organ transplant receipt or evaluation, recent PTCA, noncardiac death, and lack of follow-up. A positive stress echocardiogram (SE) was defined as new or worsened wall-motion abnormalities (WMAs) consistent with ischemia during DSE. Classification and regression tree (CART) analysis identified variables that best predicted future cardiac events. RESULTS: The average age was 68+/-12 years, with 338 women and 220 men. The overall cardiac event rate was 34% if SE was positive, and 10% if it was negative. The event rates for MI and death were 10% and 8%, respectively, if SE was positive, and 3% and 3%, respectively, if SE was negative. If an ischemic electrocardiogram (ECG) and a positive SE were present, the overall event rate was 42%, versus a 7% rate when ECG and SE were negative for ischemia. Rest WMA was the most useful variable in predicting future cardiac events using CART: 25% of patients with and 6% without a rest WMA had an event. Other important variables were a dobutamine EF <52.5%, a positive SE, an ischemic ECG response, history of hypertension and age. CONCLUSIONS: A positive SE provides useful prognostic information that is enhanced by also considering rest-wall motion, stress ECG response, and dobutamine EF.  (+info)

Integrated evaluation of relation between coronary lesion features and stress echocardiography results: the importance of coronary lesion morphology. (4/1123)

OBJECTIVES: The aim of this study was to analyze, in the same group of patients, the relationship between multiple variables of coronary lesion and results of exercise, dobutamine and dipyridamole stress echocardiography tests. BACKGROUND: Integrated evaluation of the relation between stress echocardiography results and angiographic variables should include not only the assessment of stenosis severity but also evaluation of other quantitative and qualitative features of coronary stenosis. METHODS: Study population consisted of 168 (138 male, 30 female, mean age 51+/-9 years) patients, on whom exercise (Bruce treadmill protocol), dobutamine (up to 40 mcg/kg/min) and dipyridamole (0.84 mg/kg over 10 min) stress echocardiography tests were performed. Stress echocardiography test was considered positive for myocardial ischemia when a new wall motion abnormality was observed. One-vessel coronary stenosis ranging from mild stenosis to complete obstruction of the vessel was present in 153 patients, and 15 patients had normal coronary arteries. The observed angiographic variables included particular coronary vessel, stenosis location, the presence of collaterals, plaque morphology according to Ambrose classification, percent diameter stenosis and obstruction diameter as assessed by quantitative coronary arteriography. RESULTS: Covariates significantly associated with the results of physical and pharmacological stress tests included for all three stress modalities presence of collateral circulation, percent diameter stenosis and obstruction diameter, as well as lesion morphology (p < 0.05 for all, except collaterals for dobutamine stress test, p = 0.06). By stepwise multiple logistic regression analysis, the strongest predictor of the outcome of exercise echocardiography test was only percent diameter stenosis (p = 0.0002). However, both dobutamine and particularly dipyridamole stress echocardiography results were associated not only with stenosis severity - percent diameter stenosis (dobutamine, p = 0.04; dipyridamole, p = 0.003) - but also, and even more strongly, with lesion morphology (dobutamine, p = 0.006; dipyridamole, p = 0.0009). As all of stress echocardiography results were significantly associated with percent diameter stenosis, the best angiographic cutoff in relation to the results of stress echocardiography test was: exercise, 54%; dobutamine, 58% and dipyridamole, 60% (p < 0.05 vs. exercise). CONCLUSIONS: Integrated evaluation of angiographic variables have shown that the results of dobutamine and dipyridamole stress echocardiography are not only influenced by stenosis severity but also, and even more importantly, by plaque morphology. The results of exercise stress echocardiography, although separately influenced by plaque morphology, are predominantly influenced by stenosis severity, due to a stronger exercise capacity in provoking myocardial ischemia in milder forms of coronary stenosis.  (+info)

Functional status and quality of life in patients with heart failure undergoing coronary bypass surgery after assessment of myocardial viability. (5/1123)

OBJECTIVES: The aim of this study was to evaluate whether preoperative clinical and test data could be used to predict the effects of myocardial revascularization on functional status and quality of life in patients with heart failure and ischemic LV dysfunction. BACKGROUND: Revascularization of viable myocardial segments has been shown to improve regional and global LV function. The effects of revascularization on exercise capacity and quality of life (QOL) are not well defined. METHODS: Sixty three patients (51 men, age 66+/-9 years) with moderate or worse LV dysfunction (LVEF 0.28+/-0.07) and symptomatic heart failure were studied before and after coronary artery bypass surgery. All patients underwent preoperative positron emission tomography (PET) using FDG and Rb-82 before and after dipyridamole stress; the extent of viable myocardium by PET was defined by the number of segments with metabolism-perfusion mismatch or ischemia. Dobutamine echocardiography (DbE) was performed in 47 patients; viability was defined by augmentation at low dose or the development of new or worsening wall motion abnormalities. Functional class, exercise testing and a QOL score (Nottingham Health Profile) were obtained at baseline and follow-up. RESULTS: Patients had wall motion abnormalities in 83+/-18% of LV segments. A mismatch pattern was identified in 12+/-15% of LV segments, and PET evidence of viability was detected in 30+/-21% of the LV. Viability was reported in 43+/-18% of the LV by DbE. The difference between pre- and postoperative exercise capacity ranged from a reduction of 2.8 to an augmentation of 5.2 METS. The degree of improvement of exercise capacity correlated with the extent of viability by PET (r = 0.54, p = 0.0001) but not the extent of viable myocardium by DbE (r = 0.02, p = 0.92). The area under the ROC curve for PET (0.76) exceeded that for DbE (0.66). In a multiple linear regression, the extent of viability by PET and nitrate use were the only independent predictors of improvement of exercise capacity (model r = 0.63, p = 0.0001). Change in Functional Class correlated weakly with the change in exercise capacity (r = 0.25), extent of viable myocardium by PET (r = 0.23) and extent of viability by DbE (r = 0.31). Four components of the quality of life score (energy, pain, emotion and mobility status) significantly improved over follow-up, but no correlations could be identified between quality of life scores and the results of preoperative testing or changes in exercise capacity. CONCLUSIONS: In patients with LV dysfunction, improvement of exercise capacity correlates with the extent of viable myocardium. Quality of life improves in most patients undergoing revascularization. However, its measurement by this index does not correlate with changes in other parameters nor is it readily predictable.  (+info)

Effects of phosphodiesterase inhibitors after coronary artery bypass grafting. (6/1123)

The aim of this study was to estimate the postoperative effects of phosphodiesterase (PDE) inhibitors (milrinone and olprinone) after coronary artery bypass grafting (CABG). To prevent hypotension caused by the PDE inhibitors, low dose of catecholamines were used concomitantly. A total of 34 elective CABG cases were tested. In 12 cases, 0.25 microg kg(-1) min(-1) of milrinone, 3 microg kg(-1) min(-1) of dobutamine (DOB) and dopamine (DOA) were used concomitantly (Group-M). In another 10 patients, 0.1 microg kg(-1) min(-1) of olprinone and the same doses of the catecholamines were infused (Group-O). As a control, the same doses of DOA and DOB only were administered in 12 patients (Group-C). When the pump flow of the cardiopulmonary bypass (CPB) decreased to half, these drugs were given in all groups. Hemodynamics were recorded before CPB, just after the operation, and 3, 6, 12, 24, 48 and 72 h after the operation. Both milrinone and olprinone increased the cardiac index and decreased systemic vascular resistance to almost the same degree. Olprinone decreased mean aortic and pulmonary artery pressures, and also significantly reduced the preload of both right and left heart compared with milrinone. Significant hypotension was not detected due to the concomitant usage of low-dose catecholamines. This concomitant usage of PDE inhibitors and catecholamines allowed easy weaning from CPB, demonstrating excellent hemodynamics after CABG. Good oxygen demand and supply balance were maintained in peripheral tissue. These results suggest that these new PDE inhibitors may be effective not only for weaning from CPB but also for post-cardiotomy cardiogenic shock.  (+info)

The functional significance of chronotropic incompetence during dobutamine stress test. (7/1123)

OBJECTIVE: To investigate the functional significance of chronotropic incompetence during dobutamine stress echocardiography. PATIENTS AND METHODS: The functional significance of chronotropic incompetence was evaluated during dobutamine stress echocardiography in 512 patients without beta blocker treatment who underwent dobutamine stress echocardiography (up to 40 microg/kg/min) and completed the protocol or reached the target heart rate. Mean (SD) age was 60 (12) years (313 men, 199 women). Chronotropic incompetence was defined as failure to achieve 85% of the maximum exercise heart rate predicted for age and sex (220 - age in men; 200 - age in women) at maximum dobutamine dose. RESULTS: Chronotropic incompetence occurred in 196 patients (38%). Affected patients were significantly younger, more likely to be men (both p << 0.001) and smokers (p < 0.05), had a higher prevalence of previous myocardial infarction (p < 0.005) and resting wall motion abnormalities (p < 0. 05), and had a lower resting heart rate (p << 0.001) and systolic blood pressure (p << 0.001) than patients without chronotropic incompetence, but there was no difference in the overall prevalence of ischaemia and significant coronary artery disease. By multivariate analysis, independent predictors of chronotropic incompetence were a lower resting heart rate (p << 0.001), younger age (p << 0.001), and male sex (p << 0.001). CONCLUSIONS: The relations among sex, age, and chronotropic incompetence show the need to titrate the dobutamine dose using specific data based on age and sex related heart rate responses to dobutamine rather than to an exercise stress test. Obtaining specific heart rate criteria is necessary to determine whether chronotropic incompetence represents a real failure to achieve a normal response or is the result of applying an inappropriate gold standard.  (+info)

Functional and molecular biological evidence for a possible beta3-adrenoceptor in the human detrusor muscle. (8/1123)

The possible existence of a beta3-adrenergic receptor (beta3-AR) in the human detrusor muscle was investigated by in vitro functional studies and analysis of mRNA expression. Isoprenaline, noradrenaline and adrenaline each produced a concentration-dependent relaxation of the human detrusor. The rank order for their relaxing potencies was isoprenaline (pD2 6.37+/-0.07) > or = noradrenaline (pD2 6.07+/-0.12) > or = adrenaline (pD2 5.88< or =0.11). Neither dobutamine (beta1- and beta2-AR agonist) nor procaterol (beta2-AR agonist) produced any significant relaxation at concentrations up to 10(-5) M. BRL37344A, CL316243 and CGP-12177A (beta3-AR agonists), relaxed the preparations significantly at concentrations higher than 10(-6) M. The pD2 values for BRL37344A, CL316243 and CGP-12177A were 6.42+/-0.25, 5.53+/-0.09 and 5.74+/-0.14, respectively. CGP-20712A (10(-7) - 10(-5) M), a beta1-AR antagonist, did not affect the isoprenaline-induced relaxation. On the other hand, ICI-118,551, a beta2-AR antagonist, produced a rightward parallel shift of the concentration-relaxation curve for isoprenaline only at the highest concentration used (10(-5) > M) and its pKB value was 5.71+/-0.19. Moreover, SR58894A (10(-7) - 10(-5) M), a beta3-AR antagonist, caused a rightward shift of the concentration-relaxation curve for isoprenaline in a concentration-dependent manner. The pA2 value and slope obtained from Schild plots were 6.24+/-0.20 and 0.68+/-0.31. The beta1-, beta2- and beta3-AR mRNAs were all positively expressed in detrusor smooth muscle preparations in a reverse transcription polymerase chain reaction assay. In conclusion, the present results provide the first evidence for the existence of the beta3-AR subtype in the human detrusor. They also suggest that the relaxation induced by adrenergic stimulation of the human detrusor is mediated mainly through beta3-AR activation.  (+info)

In this study we showed that the use of second harmonic imaging during dobutamine stress echocardiography improved the accuracy of the detection of viable myocardium in patients with severe left ventricular dysfunction compared with fundamental imaging, DISA-SPECT being used as a reference method. Compared with fundamental imaging, the agreement between dobutamine stress echocardiography and DISA-SPECT on viability assessment increased significantly from 78% (κ = 0.56) to 89% (κ = 0.77) when second harmonic imaging was used (p = 0.001).. Although the use of combined low/high dose dobutamine echocardiography has improved the accuracy of dobutamine stress echocardiography for detecting viability,21 22 there remains some discordance between dobutamine echocardiography and nuclear imaging.23-25 Previous studies have shown that 201thallium classified a significantly higher percentage of segments as viable compared with dobutamine stress echocardiography.7 24 A similar discrepancy was observed ...
TY - JOUR. T1 - The Doppler myocardial performance index during low-dose dobutamine echocardiography predicts mortality and left ventricular dilation after a first acute myocardial infarction. AU - Nørager, Betina. AU - Husic, Mirza. AU - Møller, Jacob E.. AU - Pellikka, Patricia A.. AU - Appleton, Christopher P.. AU - Egstrup, Kenneth. PY - 2005/9. Y1 - 2005/9. N2 - Background: Myocardial viability can be detected by wall motion analysis during low-dose dobutamine echocardiography (LDDE) after acute myocardial infarction (AMI). However, wall motion analysis describes only left ventricular (LV) systolic reserve. The Doppler myocardial performance index (MPI) is a quantitative measure of combined LV systolic and diastolic function. We hypothesized that an increase (deterioration) in MPI during LDDE, reflecting reduced systolic and diastolic LV reserve, could provide prognostic information beyond conventional systolic wall motion analysis on mortality, morbidity, and LV remodeling after AMI. ...
TY - JOUR. T1 - Contractile reserve of dysfunctional myocardium after revascularization: A dobutamine stress echocardiography study. AU - Lombardo, Antonella. AU - Trani, Carlo. AU - Rossi, Elena. AU - Giordano, Alessandro. AU - Loperfido, Francesco. AU - Pennestri, Faustino. PY - 1997. Y1 - 1997. N2 - Objectives. We sought to investigate the effects of revascularization on the contractile reserve of dysfunctional myocardium. Background. The improvement in dysfunctional but viable myocardium after revascularization is frequently less than expected from the amount of contractile reserve detected on dobutamine stress echocardiography. The fate of the contractile reserve, when it does not result in an adequate contractile recovery, is unknown. Methods. Basal contraction and contractile reserve of infarct zones were assessed by dobutamine stress echocardiography in 21 postinfarction male patients before and ,3 months after revascularization (30 infarct zones; mean ± SD left ventricular ejection ...
TY - JOUR. T1 - Inotropic contractile reserve can risk-stratify patients with HIV cardiomyopathy. T2 - A dobutamine stress echocardiography study. AU - Wever-Pinzon, Omar. AU - Bangalore, Sripal. AU - Romero, Jorge. AU - Silva Enciso, Jorge. AU - Chaudhry, Farooq A.. PY - 2011/12/1. Y1 - 2011/12/1. N2 - The purpose of this study was to assess whether inotropic contractile reserve (ICR) during dobutamine stress echocardiography (DSE) could risk-stratify patients with human immunodeficiency virus (HIV) cardiomyopathy and predict improvement of left ventricular ejection fraction (LVEF). HIV cardiomyopathy is an important cause of heart failure and death. ICR is associated with better survival and improvement of LVEF in patients with ischemic and nonischemic cardiomyopathies. However, the prognostic value of ICR in patients with HIV cardiomyopathy is unknown. Patients with HIV cardiomyopathy and a LVEF ,45% who were referred for DSE were enrolled. ICR was evaluated by the delta wall motion score ...
Is there a long-term predictive value of intraoperative low-dose dobutamine echocardiography in patients who have coronary artery bypass graft surgery with cardiopulmonary bypass?
Objective: To evaluate the relative merits of viability and ischaemia for prognosis after revascularisation.. Methods: Low-high dose dobutamine stress echocardiography (DSE) was performed before revascularisation in 128 consecutive patients with ischaemic cardiomyopathy (mean (SD) left ventricular ejection fraction (LVEF) 31 (8)%). Viability (defined as contractile reserve (CR)) and ischaemia were assessed during low and high dose dobutamine infusion, respectively. Cardiac death was evaluated during a five year follow up. Clinical, angiographic, and echocardiographic data were analysed to identify predictors of events.. Results: Univariable predictors of cardiac death were the presence of multivessel disease (hazard ratio (HR) 0.21, p , 0.001), baseline LVEF (HR 0.90, p , 0.0001), wall motion score index (WMSI) at rest (HR 4.02, p = 0.0006), low dose DSE (HR 7.01, p , 0.0001), peak dose DSE (HR 4.62, p , 0.0001), the extent of scar (HR 1.39, p , 0.0001), and the presence of CR in ⩾ 25% of ...
The major new finding of this study is the evidence that systemic BP changes are important determinants of peripheral sympathetic nerve control and HR response during dobutamine infusion. In young controls, dobutamine infusion markedly increased BP, which activated the arterial baroreceptors leading to subsequent inhibition of MSNA, as well as to limitation in the increase in HR. In contrast, the BP response to dobutamine was much less marked in the matched controls and, in the absence of arterial baroreceptor activation, dobutamine infusion did not change MSNA and did not limit the increase in HR. These findings are important as they may account for variations in the HR responses among subjects during dobutamine stress testing.. The response in the patients with severe CHF was similar to that observed in the matched controls, with no elevation in MBP and no changes in MSNA. The lack of increase in HR could be explained by the marked beta-adrenergic downregulation in end-stage HF (14). Resting ...
Dobutamine Injection manufacturers - Systacare Remedies exporters, suppliers of Dobutamine Hydrochloride Injection india, indian Dobutamine Injection,Dobutrex Injuction manufacturer, wholesale Dobutamine Hydrochloride Injection suppliers, Dobutamine Injection, Dobutamine Hydrochloride Injection, Dobutrex Injuction
Protocols for DSE vary from institution to institution, particularly with regard to dobutamine dose (range 20 to 40 μg/kg per min), atropine addition (range 0 to 2 mg) and stage duration (range 2 to 8 min) [5-32, 37]. Usually, centers that use lower peak doses of dobutamine use longer stage durations and stop beta-adrenergic blocking agent treatment more often before the test. To date, the most widely used protocol uses dobutamine up to 40 μg/kg per min, with the addition of atropine up to 1 mg [14].. According to this protocol, a rest electrocardiogram (ECG) and two-dimensional echocardiogram are acquired, intravenous access is secured, and dobutamine is then administered intravenously by an infusion pump, starting at 5 or 10 μg/kg per min for 3 min, increasing by 10 μg/kg per min every 3 min up to a maximum of 40 μg/kg per min. In patients not achieving 85% of their theoretic maximal heart rate (220 beats/min minus age for men, beats/min 200 minus age for women) and without symptoms or ...
Introduction: Patients with severe aortic stenosis and low mean transvalvular gradient have poor outcomes with an estimated 30 day post-surgical Aortic Valve Replacement (AVR) mortality of 21%. Low Dose Dobutamine Stress Echocardiography (LD-DSE) is performed in these patients for further risk stratification by determining the presence of myocardial reserve - defined as an at least 20% increase in stroke volume with Dobutamine infusion. These patients have lower perioperative mortality. However, it is unclear if LD-DSE can predict outcomes in high surgical risk patients undergoing Transcatheter Aortic Valve Implantation (TAVI).. Methods: We retrospectively identified patients from the PARTNER trial who underwent TAVI and had a LD-DSE as part of the inclusion criteria when the resting mean aortic gradient is ,40 mmHg. Outcomes identified in these patients after TAVI include re-hospitalizations for cardiac causes and mortality at 30 days and at one year.. Results: Twenty-four patients who ...
To study the effects of Beta-blockers during Dobutamine Stress Echocardiography (DSE) comparing the hemodynamic benefits of an early administration of atropine in patients taking or not Beta-blockers. One hundred and twenty-one patients were submitted to dobutamine stress echocardiography for the investigation of myocardial ischemia. The administration of atropine was randomized into two groups: A or B (early protocol when atropine was administered at 10 and 20 mcg/kg/min of dobutamine, respectively) and C (standard protocol with atropine at 40 mcg/kg/min of dobutamine). Analysis of the effects of Beta-blockers was done regarding the behavior pattern of heart rate and blood pressure, test time, number of conclusive and inconclusive (negative sub-maximum test) results, total doses of atropine and dobutamine, and general complications. Beta-blocked patients who received early atropine (Group A&B) had a significantly lower double product (p = 0.008), a higher mean test time (p = 0.010) and required a
Current techniques for diagnosing perioperative myocardial infarction were studied in 58 patients who underwent coronary bypass surgery. All patients had preoperative and postoperative ECGs and technetium-99m stannous pyrophosphate myocardial scintigrams; serum CK-MB was measured immediately after surgery and daily for 3 days. Postoperative bypass graft visualization and left ventriculography were performed before hospital discharge in every patient. Nine patients (16%) had new Q waves postoperatively. Five of these nine patients had positive pyrophosphate scintigrams, postive CK-MB and new wall motion abnormalities, and the remaining four had negative CK-MB, negative phyrophosphate scintigrams and no new wall motion abnormalities. Seven patients (12%) had newly positive postoperative pyrophosphate scintigrams, positive CK-MB and new wall motion abnormalities on postoperative ventriculography, but only four had new Q waves postoperatively. Eight patients (14%) had new wall motion abnormalities; ...
The aim of this study was to investigate the temporal variability and interobserver agreement of dobutamine digital stress echocardiography. We performed two dobutamine stress echocardiographic studies (dobutamine up to 40 micrograms/kg/min and atrop
A dobutamine stress echocardiogram is a diagnostic procedure that may be used when a doctor wants to assess the heart muscle under stress. If exercise on a treadmill is not an option (too much stress on the heart) due to a persons medical condition, a doctor may use an intravenous medication called dobutamine. Dobutamine causes the heart to beat faster and will mimic the effects of exercise on the heart.. An echocardiogram is a noninvasive (the skin is not pierced) procedure used to assess the hearts function and structures. During the procedure, a transducer (like a microphone) sends out ultrasonic sound waves at a frequency too high to be heard. When the transducer is placed on the chest at certain locations and angles, the ultrasonic sound waves move through the skin and other body tissues to the heart tissues, where the waves bounce or echo off of the heart structures. The transducer picks up the reflected waves and sends them to a computer. The computer displays the echoes as images of ...
A dobutamine stress echocardiogram is a diagnostic test to assess the heart muscle under stress. If exercise on a treadmill is not an option (too much stress on the heart) due to a persons medical condition, a doctor may use an intravenous medicine called dobutamine. Dobutamine causes the heart to beat faster and will mimic the effects of exercise on the heart.
TY - JOUR. T1 - Real-Time Three-Dimensional Dobutamine Stress Echocardiography. T2 - A Valuable Adjunct or a Superior Alternative to Two-Dimensional Stress Echocardiography?. AU - Ahmad, Masood. PY - 2009/5. Y1 - 2009/5. UR - http://www.scopus.com/inward/record.url?scp=65549091149&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=65549091149&partnerID=8YFLogxK. U2 - 10.1016/j.echo.2009.03.024. DO - 10.1016/j.echo.2009.03.024. M3 - Article. C2 - 19450740. AN - SCOPUS:65549091149. VL - 22. SP - 443. EP - 444. JO - Journal of the American Society of Echocardiography. JF - Journal of the American Society of Echocardiography. SN - 0894-7317. IS - 5. ER - ...
Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the β receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine. In animal studies, dobutamine hydrochloride produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol.. In patients with depressed cardiac function, both dobutamine hydrochloride and isoproterenol increase the cardiac output to a similar degree. In the case of dobutamine hydrochloride, this increase is usually not accompanied by marked increases in heart rate (although tachycardia is occasionally observed), and the cardiac stroke volume is usually increased. In contrast, isoproterenol increases the cardiac index primarily by increasing the heart rate while stroke volume changes little or ...
The pharmacological effects of dobutamine (see Table 10-1 for structure) result from direct interactions with a and b receptors and are complex. The preparation of dobutamine used clinically is a racemate. The (-) isomer of dobutamine is a potent a1 agonist and pressor; (+) dobutamine is a potent a1 antagonist that can block the effects of (-) dobutamine. Both isomers are full agonists at b receptors, but the (+) isomer is more potent than the (-) isomer by -tenfold.. Was this article helpful?. ...
Dobutamine Injection, USP is a clear, practically colorless, sterile, nonpyrogenic solution of dobutamine hydrochloride for intravenous use only. Each milliliter contains 12.5 mg (41.5 µmol) dobutamine, as the hydrochloride and sodium metabisulfite, 0.2 mg added as antioxidant. May contain hydrochloric acid and/or sodium hydroxide for pH adjustment. pH is 3.3 (2.5 to 5.5).. Dobutamine Hydrochloride, USP is chemically designated (±)-4-[2-[[3-(ρ-hydroxyphenyl)-1-methylpropyl] amino]ethyl]-pyrocatechol hydrochloride.. It is a synthetic catecholamine.. ...
Thesis, English, Role of Mitral Inflow Patterns as a Predictor of Absence of Myocardial Viability Detected by Dobutamine Stress Echocardiography in Patients With Ischemic Cardiomyopathy for Fathy Mohamed Ismail Heba
Dobutamine stress echocardiograms are used to diagnose certain heart conditions. This type of echocardiogram was created for patients who are physically unable to exercise on a treadmill or stationary cycle. This type of echocardiogram utilizes a special medication called dobutamine. Essentially, this medication mimics regular echocardiograms, stimulating your heart so it appears that you are exercising. The dobutamine allows cardiologists to:. ...
Dobutamine stress echocardiography (DSE) is an accurate noninvasive test used for the diagnosis and evaluation of patients with known or suspected coronary artery disease (CAD). The aim of this study was to determine the rate of positive findings in
[Coronary Spasm after Administration of Propranolol during Dobutamine Stress Echocardiography]. - Lucía Alvarez, José Zamorano, Luis Mataix, Carlos Almeria, Raúl Moreno, José Luis Rodrigo
TY - JOUR. T1 - Dobutamine inhibits monocyte chemoattractant protein-1 production and chemotaxis in human monocytes. AU - Li, Chi Yuan. AU - Tsai, Chien Sung. AU - Chueh, Sheau Huei. AU - Hsu, Ping Ching. AU - Wang, Jia Yi. AU - Wong, Chih Shung. AU - Ho, Shung Tai. PY - 2003/7/1. Y1 - 2003/7/1. N2 - It has been reported that, in patients with acute myocardial infarction or congestive heart failure, monocyte chemoattractant protein-1 (MCP-1) plays an important role in the development of inflammatory responses and that the level of MCP-1 is correlated with the severity of the disease. We conducted this study to investigate the effects of dobutamine and dopamine on lipopolysaccharide (LPS)-induced MCP-1 production in human monocytic THP-1 cells. Monocytes were incubated in vitro with LPS for 16 h at 37°C in the presence or absence of dobutamine or dopamine. Enzyme-linked immunosorbent assay was used to examine the effect of dobutamine on MCP-1 synthesis, with the MCP-1 messenger RNA expression ...
Definition of dobutamine in the Definitions.net dictionary. Meaning of dobutamine. What does dobutamine mean? Information and translations of dobutamine in the most comprehensive dictionary definitions resource on the web.
TY - JOUR. T1 - Effectiveness and need for follow-up invasive testing in patients undergoing initial preoperative evaluation with dobutamine stress echocardiography compared to persantine thallium. AU - Leach, Rafer. AU - Devries, Stephen. PY - 1997/12/1. Y1 - 1997/12/1. N2 - Identification of patients at risk for cardiac complications from surgery using traditional methods of stress testing with nuclear imaging can be challenging and expensive. Objective: The purpose of this study was to compare the effectiveness and need for additional cardiac tests when stress testing prior to noncardiac surgery was performed with persantine thallium (PerT) compared to initial testing with dobutamine stress echocardiography (DSE). Methods: A retrospective review of all patients undergoing noncardiac surgery over a 3 year period was undertaken in which the initial cardiac study performed prior to surgery was either DSE or PerT. Results: A total of 262 pts underwent either DSE (n=168, age=64) or PerT (n = 94, ...
TY - JOUR. T1 - A clinical and echocardiographic score for assigning risk of major events after dobutamine echocardiograms. AU - Marwick, Thomas H.. AU - Case, Colin. AU - Poldermans, Don. AU - Boersma, Eric. AU - Bax, Jeroen. AU - Sawada, Stephen. AU - Thomas, James D.. PY - 2004/6/2. Y1 - 2004/6/2. N2 - Objectives We sought to develop and validate a risk score combining both clinical and dobutamine echocardiographic (DbE) features in 4,890 patients who underwent DbE at three expert laboratories and were followed for death or myocardial infarction for up to five years. Background In contrast to exercise scores, no score exists to combine clinical, stress, and echocardiographic findings with DbE. Methods Dobutamine echocardiography was performed for evaluation of known or suspected coronary artery disease in 3,156 patients at two sites in the U.S. After exclusion of patients with incomplete follow-up, 1,456 DbEs were randomly selected to develop a multivariate model for prediction of events. ...
Dobutamine stress echocardiogram - Cardiac ultrasound scan to assess the response of your heart to stress. Learn about costs, procedure and recovery.
Dobutamine Stress Echocardiogram clinics in Friedrichstrasse A at the best price. Find doctors, specialized in Cardiology and compare prices, costs and reviews.
Dobutamine Stress Echocardiogram clinics in Bismarckstrasse at the best price. Find doctors, specialized in Cardiology and compare prices, costs and reviews.
A stress echo is a test that takes pictures of the heart with the use of a probe placed outside your chest wall while your heart is working hard. To stress the heart, youll be given an intravenous medication (Dobutamine) that will make your heart beat harder and faster just like it would during exercise. ​​. The pictures taken before, during and after your heart is stressed are displayed on the ultrasound monitor and are recorded on a disk for review and comparison. A dobutamine stress echo is performed by a sonographer and interpreted by a cardiologist ...
Propranolol is a competitive antagonist which specifically competes with beta-adrenergic. by sufficient doses of such agonists as isoproterenol or dobutamine.Hemodynamic Effects of Atropine, Dobutamine, Nitroprusside, Phenylephrine, and Propranolol in Conscious Horses.. Antimigraine, Cardiovascular Agent (About this - PubMed Health).Medications that have been reported to negatively interact with propranolol include clonidine, digitalis, dobutamine, haloperidol, isoproterenol, blood ...
Preventing perioperative tissue oxygen debt contributes to a better postoperative recovery. Whether the beneficial effects of fluids and inotropes during optimization of the oxygen delivery index (DO2I) in high-risk patients submitted to major surgeries are due to fluids, to inotropes, or to the combination of the two is not known. We aimed to investigate the effect of DO2I optimization with fluids or with fluids and dobutamine on the 60-day hospital mortality and incidence of complications. A randomized and controlled trial was performed in 50 high-risk patients (elderly with coexistent pathologies) undergoing major elective surgery. Therapy consisted of pulmonary artery catheter-guided hemodynamic optimization during the operation and 24 hours postoperatively using either fluids alone (n = 25) or fluids and dobutamine (n = 25), aiming to achieve supranormal values (DO2I | 600 ml/minute/m2). The cardiovascular depression was an important component in the perioperative period in this group of patients.
TY - JOUR. T1 - A method of detecting and quantifying severity of myocardial perfusion defects with intravenous ultrasound contrast and breath holding during stress echocardiography. AU - Porter, Thomas Richard. AU - OLeary, Edward Lewis. AU - Silver, Mary. AU - Oehlke, Heidi. AU - Xie, Feng. PY - 2003/7/1. Y1 - 2003/7/1. N2 - Although breath holding is commonly used to improve and maintain image quality during stress echocardiography, its effects on the qualitative and quantitative analysis of myocardial contrast enhancement (MCE) following intravenously injected microbubbles is unknown. The purpose of this study was to determine how breath holding affects MCE following either an intravenous bolus or continuous infusion of perfluorocarbon containing microbubbles. In 48 patients, intravenous Optison was given at peak dobutamine stress to assess myocardial perfusion. The degree of myocardial opacification was assessed immediately following a breath hold in inspiration (BHini), at the end of a ...
TY - JOUR. T1 - Comparison of effects of thrombolytic therapy followed by elective coronary intervention and direct coronary intervention in acute myocardial infarction. T2 - Usefulness of dobutamine stress echocardiography. AU - Hasegawa, K.. AU - Iwase, M.. AU - Matsuyama, H.. AU - Kimura, M.. AU - Koie, S.. AU - Kato, C.. AU - Yamamoto, H.. AU - Hatada, A.. AU - Ishii, J.. AU - Nomura, M.. AU - Watanabe, Y.. AU - Hishida, H.. PY - 1997/12/1. Y1 - 1997/12/1. N2 - The effects of intravenous administration of tissue plasminogen activator (t-PA) followed by elective percutaneous transluminal coronary angioplasty (PTCA) were compared to those of direct PTCA (d-PTCA) in patients with acute myocardial infarction using dobutamine stress echocardiography 1 week and 1 month after the acute episode. There were 12 patients in the t-PA group and nine patients in the d-PTCA group. Dobutamine was infused at incremental doses (5 μg/kg/min for each 5 min step). Wall motion changes were classified during ...
We found perfect matching of intraoperative NWMAs location with postoperative electrocardiographic locality of MI, indicating the accumulation of most perioperative stressors on the vulnerable myocardium of the vascular surgery patient in the intraoperative phase exhausting the moribund coronary reserve around the end of surgery, which would hence yield most fatal MIs in the immediate postoperative phase up to 12 h. This coincides with the well-established knowledge that more than 50% of perioperative MIs do occur in the immediate postoperative period and lead to recommending twice daily electrocardiography in the first postoperative day. In addition, we reported postoperative cTnT release in 14 patients (26%). In 8 (57%) of them, troponin release was not associated with MI. Le Manach et al . found earlier postoperative abnormal troponin in a larger cohort of vascular surgery patients (14% of 1,136 patient population). Increased cardiac troponins were related to postoperative MI (in 35% of the ...
1. We have studied whether the progressive rise in peripheral resistance observed in response to chronic intracoronary administration of dobutamine in conscious dogs could have resulted from extracardiac or non-β-adrenergic cardiac effects of the drug.. 2. Six conscious dogs received dobutamine, 1.56 × 10−8 mol min−1 kg−1, intravenously for a 7 day period and seven conscious dogs were given dobutamine, 1.51 × 10−8 mol min−1 kg−1, into the left coronary artery under oral propranolol treatment for the same period while arterial pressure, cardiac output (electromagnetic flowmeter) and heart rate were measured.. 3. Intravenous dobutamine produced no increase in arterial pressure, but a decrease in peripheral resistance and an increase in cardiac output which persisted until the end of the infusion.. 4. With propranolol treatment intracoronary dobutamine induced no significant haemodynamic changes but a short-lasting increase in mean arterial pressure and peripheral resistance.. 5. It ...
dobutamine.%27%27 davis pdf, Visual compatibility of dobutamine with seven parenteral drug products. Am J Hosp Pharm 1980 ; 37: 460,464. 1611 Revue Chalmers JR, Bobek MB, Militello MA. Visual compatibility of amiodarone hydrochloride injection with various intravenous drugs. Am J Health-Syst Pharm 2001 ; 58: 504-506. 1625 Revue Trissel LA, Saenz C, Williams YW, Ingram D.
OBJECTIVE: To quantify regional left ventricular (LV) function and contractile reserve in Q wave and non-Q wave regions in patients with previous myocardial infarction. DESIGN: An observational study. SETTING: Tertiary care centre. PATIENTS: 81 patients with previous myocardial infarction and depressed LV function. INTERVENTIONS: All patients underwent surface ECG at rest and pulsed wave tissue Doppler imaging at rest and during low dose dobutamine infusion. The left ventricle was divided into four major regions (anterior, inferoposterior, septal, and lateral). Severely hypokinetic, akinetic, and dyskinetic regions on two dimensional echocardiography at rest were considered dysfunctional. MAIN OUTCOME MEASURES: Regional myocardial systolic velocity (Vs) at rest and the change in Vs during low dose dobutamine infusion (DeltaVs) in dysfunctional regions with and without Q waves on surface ECG. RESULTS: 220 (69%) regions were dysfunctional; 60 of these regions corresponded to Q waves and 160 were ...
Why is the doctor performing this test?. To determine how well the heart is pumping blood through the coronary arteries.. What is the test?. A dobutamine stress echo is a non-invasive ultrasound test which is used to visualize the heart in motion. To view the heart, your doctor will place a transducer on your chest which emits harmless sound waves to your heart. These sound waves generate pictures of your heart in motion and are displayed on an ultrasound machine connected to the transducer.. Your doctor will examine the muscle movement of the heart (also called wall motion) while you are at rest. Then, your doctor will inject a medication called dobutamine through an IV. This causes your heart to beat faster, simulating the effects exercise has on your heart. The doctor will then examine these pictures of your heart and compare them to the pictures taken while you were at rest.. If the results of your stress echo show decreased muscle movement (or wall motion) during stress than while resting, ...
OBJECTIVE: To determine the hemodynamic effects of the combination of norepinephrine-dobutamine in adult patients with septic shock. Specifically, we tested the hypothesis that norepinephrine in addition to dobutamine would improve cardiac index (CI) and stroke volume index (SVI) and increase left-ventricular afterload.. DESIGN: Prospective, descriptive, interventional study with no control group.. SETTING: Intensive care unit of a university hospital.. PATIENTS: Fourteen patients (group 1) were transferred to the intensive care unit from other wards with septic shock not responsive to dobutamine infusion, low blood pressure (systolic blood pressure of ,90 mm Hg), clinical and laboratory signs of infection, clinical signs of poor organ perfusion, and blood lactate of ,2.0 mmol/L. They were enrolled and treated by the addition of norepinephrine, while the dose of dobutamine remained constant. Three of these patients required additional fluid loading to achieve adequate ventricular filling ...
Detecting viable myocardium and predicting functional improvement: comparisons of positron emission tomography, rest-redistribution thallium-201 single-photon emission computed tomography (SPECT), exercise thallium-201 reinjection SPECT, I-123 BMIPP SPECT and dobutamine stress echocardiography ...
{ consumer: Helps you calculate your target heart rate based on your age, resting heart rate, and activity level. Covers using your target heart rate to know how hard to exercise to gain the most aerobic benefit from your workout., clinical: Helps you calculate your target heart rate based on your age, resting heart rate, and activity level. Covers using your target heart rate to know how hard to exercise to gain the most aerobic benefit from your workout. } Solano County, California
This study compared the use of dobutamine and dipyridamole in cardiac stress testing of patients on hemodialysis. Although dobutamine induced more pronounced myocardial ischemia than dipyridamole in chronic hemodialysis patients, use of dipyridamole more accurately identifies patients at high risk for subsequent cardiac death or non-fatal CAD ...
A stress echocardiogram (or stress echo) is a diagnostic test usually used to assess for coronary artery disease but can also be used in assessment of valvular heart disease. It is an ultrasound test performed both at rest and then with the heart under stress. The stress is achieved either by exercising on a treadmill or by receiving a medication which stimulates the heart - see dobutamine stress echocardiogram. Your doctor will decide which is the better option for you. The test takes around 1 hour.
This study was a retrospective review of 85 patient charts that found a low cost-effectiveness of using American College of Cardiology/American Heart Association guidelines for obtaining preoperative dobutamine stress echocardiograms. Suggested modifications of these guidelines should improve their …
Left myocardial infarction (MI), has a negative impact of long term morbidity and mortality. Even in patients treated successfully by angioplasty in the acute phase of infarct, the remodelling is observed in approximately 30% of cases. It is important to predict the occurrence of this phenomenon in the early phase after MI for the selection of patients who could eventually benefit from new therapeutic approach as for example cell replacement therapy. It has been advocated that stem cells coronary injections should be performed between the 5th and 10th day after an acute event. We hypothesise that a low dose dobutamine gated Tc-99m-mibi SPECT performed on 5th-6th day after reperfused acute MI can predict left ventricular remodelling and serve as a method to screen patients who could benefit from cell replacement therapy ...
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of NTU Repository with Academic Hub to form NTU Scholars.. ...
Swedish University dissertations (essays) about LOW-DOSE DOBUTAMINE. Search and download thousands of Swedish university dissertations. Full text. Free.
Approximately 40% of patients with aortic stenosis (AS) show discordant Doppler-echocardiographic parameters with aortic valve area (AVA) <1 cm2 and/or index iAVA <0.6 cm2/m2 (consistent with severe AS) and the mean gradient (MG) <40 mmHg, consistent with mild/moderate AS. Accurate diagnosis of true severe low flow low gradient AS versus pseudo-severe aortic stenosis is important for prognosis and optimal timing for intervention. Doppler echocardiography using intravenous low dose dobutamine challenge is widely used for differentiating pseudo-severe from true severe aortic stenosis. However, relying on echocardiography alone may have limitations in accurate diagnosis. Reliable diagnosis using echocardiography is dependent on multiple factors like the angle of interrogation of the aortic jet, the assumption that the LVOT area is circular in cross section, optimal echo windows, the presence of underlying subclinical coronary artery disease prior to dobutamine challenge etc. In this chapter, we
This Exercise Target Heart Rate calculator helps you to determine your target heart rate, fat burning zone, aerobic zone, maximum heart rate and red zone in accordance to your gender and age.
Cardiac magnetic resonance (CMR) imaging can be used to assess myocardial viability. Preserved myocardial wall thickness of more than 5.5 mm has a good sensitivity of 95%, but low specificity for detecting myocardial viability on CMR.. Delayed or late gadolinium enhancement (LGE) on CMR indicates myocardial scar. If the extent of scar is less as indicated by less than 50% transmural extent of hyperenhancement indicates viability. If 4 or more dysfunctional segments show viability, it has a good sensitivity of 95%, again with low specificity of 45%.. Dobutamine cine MRI is useful in assessing the contractile reserve of the myocardium. Improvement in myocardial thickening of more than 2 mm with low dose dobutamine CMR is indicative of viability.. CMR has the advantage of an accurate assessment of the extent of myocardial scar with superior spatial resolution. Wall thickness can be accurately measured by CMR. The image quality is not limited by characteristics of patient chest wall as in ...
Wondering whether its safe to exceed your target heart rate during intense exercise? Heres what you need to know about tracking your heart rate-and staying safe-while you move.
Devons target heart rate zone is 140bpm-177bpm. Julians target heart rate zone is 148bpm-181bpm. They stop running and take their pulse, and both c...
Coronary heart disease (CHD) continues to be a major global cause of death and morbidity. Tremendous resources have been invested in diagnosing CHD and predicting CHD mortality and morbidity. Although Framingham and other risk scores have contributed importantly to risk stratification of patients with suspected CHD, they are imperfect. Consequently, major efforts have been devoted to investigating the incremental utility of cardiac noninvasive imaging techniques, serum biomarkers, and so on, in predicting mortality and morbidity in patients with suspected CHD.. In this issue of iJACC, Gaibazzi, et al. (1) present the results of a retrospective multicenter transthoracic echocardiography assessment of the value of an echocardiographic calcium score (eCS) in addition to stress-induced left ventricular (LV) wall motion abnormalities (WMAs) as detected by exercise or pharmacological stress echocardiography in predicting myocardial infarction (MI) and all-cause mortality. Patients from 6 centers (n = ...
TY - JOUR. T1 - Opposite patterns of left ventricular remodeling after coronary revascularization in patients with ischemic cardiomyopathy. T2 - Role of myocardial viability. AU - Rizzello, Vittoria. AU - Poldermans, Don. AU - Boersma, Eric. AU - Biagini, Elena. AU - Schinkel, Arend F L. AU - Krenning, Boudewijn. AU - Elhendy, Abdou. AU - Vourvouri, Eleni C.. AU - Sozzi, Fabiola B.. AU - Maat, Alexander. AU - Crea, Fffippo. AU - Roelandt, Jos R T C. AU - Bax, Jeroen J.. PY - 2004/10/19. Y1 - 2004/10/19. N2 - Background-In patients with ischemic cardiomyopathy, left ventricular (LV) remodeling is an important prognostic indicator. The precise relation between viable myocardium, revascularization, and ongoing or reversed remodeling is unknown and was evaluated in the present study. Methods and Results-A total of 100 patients with ischemic cardiomyopathy underwent dobutamine stress echocardiography to assess myocardial viability and LV geometry (volumes and shape). At a mean of 10.2 months and 4.5 ...
in American Heart Journal (2001), 141(5), 772-9. BACKGROUND: The clinical significance of stress-induced ST elevation early after acute myocardial infarction and its relation to functional recovery remain controversial. The aims of this study were (1 ... [more ▼]. BACKGROUND: The clinical significance of stress-induced ST elevation early after acute myocardial infarction and its relation to functional recovery remain controversial. The aims of this study were (1) to determine the incidence of ST elevation during dobutamine and exercise tests and (2) to assess the relative accuracy of exercise and dobutamine ST elevation for predicting functional recovery after acute myocardial infarction. METHODS AND RESULTS: We investigated 52 patients who underwent supine exercise (from 25 W to maximal charge) and dobutamine (from 5 to 40 microg/kg per minute and up to 1 mg atropine) stress electrocardiography in the same position. ST elevation was defined as new or worsening at ,1 mm, 80 ms after J point. ...
Exercise Advisory. Any adult with an existing medical condition such as heart disease, asthma, high blood pressure and/or diabetes should talk with their doctor before beginning any exercise program.. A healthy, but out of shape adult, might start with a 15-minute brisk walk every day. Add 5 minutes to your walk every 5-6 days. Your goal should be a 30-minute brisk walk 3-4 times a week.. Target Heart Rate- Advisory. Target heart rate is what you want to reach in order to exercise your heart. Your range is based on age and gender ...
In patients with an intermediate likelihood for the presence of coronary artery disease (CAD), most of todays guidelines require proof of myocardial ischemia before invasive angiography. Similarly, significant myocardial ischemia should be demonstrated before revascularization. The most recent European Society of Cardiology guidelines for patients with stable coronary artery disease leave the choice of the test to the practitioner on the basis of local expertise (1). The recently published multimodality appropriateness criteria for detection and risk assessment in stable ischemic heart disease have rated various imaging modalities on the basis of existing evidence, assuming they are equally available with appropriate quality and expertise, while suggesting to keep cost-effectiveness and value in mind when ordering such tests (2).. Direct comparisons between different imaging modalities are rare, as patients have to undergo both imaging modalities as well as an invasive reference standard to ...
Now that you know what your target heart rate should be, you can calculate your heart or pulse rate using a watch. To take your wrist, or radial, pulse, hold one hand in front of you palm upward. Gently place the index and middle fingers of the other hand near the thumb-side of the wrist to feel the pulse. You should not need to press hard to feel the pulse. It is generally better to check the radial pulse, but if for some reason you need to check your neck, or carotid pulse, be sure to check only one side at a time. Never press hard. Count the beats for 10 seconds, then multiply this number by 6 to give you the beats per minute. This method is fine for many exercisers. If you like the idea of having that information instantly available in the middle of a workout, you might want to buy a monitor. Heart rate monitors arent as exact as an electrocardiogram (ECG) test, but they can be very accurate. The most inexpensive models have 2 parts: a small transmitter mounted on a belt that wraps around ...
Your target heart rate is the range at which sustained physical activity - running, cycling, swimming laps, or any other aerobic exercise - is considered safe and effective.
Your target heart rate is the range at which sustained physical activity - running, cycling, swimming laps, or any other aerobic exercise - is considered safe and effective.
Your target heart rate is the range at which sustained physical activity - running, cycling, swimming laps, or any other aerobic exercise - is considered safe and effective.
Your target heart rate is the range at which sustained physical activity - running, cycling, swimming laps, or any other aerobic exercise - is considered safe and effective.
Do you know about Target Heart Rate zones? Want to get real weight loss or build stamina, then read this article to find out more with weightlossforgood.co.uk
Exercising below your target heart rate zone will decrease your water intake decrease the effectiveness of your workout decrease your lung capaci...
Stress echocardiography, or stress echo, is a test that records images of your heart before and after exercise. By comparing the images, your doctor can tell whether your heart is getting enough blood to meet its increased demand for oxygen.
Prof. Peter Vale a specialist in cardiac and vascular medicine who provides stress echocardiography treatment in Wollstonecraft NSW.
In early October, 2007, I had to go to the hospital for two tests. These were two of many tests that had to be done to become a candidate for a transplant. One was a pulmonary test to have the arterial blood gases drawn. They take blood from an artery, not a vein. Next, pure oxygen is inhaled through the mouth with nose clips on the nose for 20 minutes. After that they draw blood from the artery again. The first arterial draw was simple, but the second one, she couldnt find my artery. It moved away and hid. My veins always did the same thing. Every time I had to have an I.V., they always had problems getting it into a vein. The second test was a dobutamine stress echocardiogram. This is where they put an I.V. in and take pictures with an ultrasound as they increase the dosage of the drug into the system to make the heart rate speed up as if excercising while laying down. They said my heart was very photogenic because they got some great pictures. However, when they put in the drug that slows ...
In early October, 2007, I had to go to the hospital for two tests. These were two of many tests that had to be done to become a candidate for a transplant. One was a pulmonary test to have the arterial blood gases drawn. They take blood from an artery, not a vein. Next, pure oxygen is inhaled through the mouth with nose clips on the nose for 20 minutes. After that they draw blood from the artery again. The first arterial draw was simple, but the second one, she couldnt find my artery. It moved away and hid. My veins always did the same thing. Every time I had to have an I.V., they always had problems getting it into a vein. The second test was a dobutamine stress echocardiogram. This is where they put an I.V. in and take pictures with an ultrasound as they increase the dosage of the drug into the system to make the heart rate speed up as if excercising while laying down. They said my heart was very photogenic because they got some great pictures. However, when they put in the drug that slows ...
Amrinone is a nonglycosidic, non-catecholamine-dependent, inotropic vasodilator agent that has recently been made available for intravenous use in patients with severe heart failure. Because other agents, such as dopamine, dobutamine, and nitroprusside, are available and have actions similar to those of amrinone in patients with heart failure, the usefulness of this newer agent must be put in perspective.. Amrinone is advertised as a major advance in inotropic therapy because of its alleged advantages of more sustained action than dopamine or dobutamine and reduction of myocardial oxygen demand. The evidence for these claims and their importance appears minimal. Recent reports indicate ...
TY - JOUR. T1 - Quality control of stress echocardiography. AU - Feigenbaum, H.. PY - 1997/1/1. Y1 - 1997/1/1. UR - http://www.scopus.com/inward/record.url?scp=0031056388&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0031056388&partnerID=8YFLogxK. U2 - 10.1136/hrt.77.2.97. DO - 10.1136/hrt.77.2.97. M3 - Short survey. C2 - 9068386. AN - SCOPUS:0031056388. VL - 77. SP - 97. EP - 98. JO - Heart. JF - Heart. SN - 1355-6037. IS - 2. ER - ...
Stress Echocardiography is offered at Apollo Hospitals in India to assess the overall function & determines any presence of disease in heart. Visit our website today!
Eventbrite - Echo Dept - Wythenshawe Hospital presents Practical Stress Echocardiography - Friday, 31 January 2020 at Education and Reseach Centre (ERC), Wythenshawe, England. Find event and ticket information.
Background The target was to compare the worthiness lately gadolinium enhancement (LGE) and end-diastolic wall thickness (EDWT) assessed by cardiovascular magnetic resonance (CMR) in predicting recovery of remaining ventricular function after coronary artery bypass surgery (CABG). wall structure motion improvement. Assessment of Receiver-Operator-Characteristic (ROC) curves Apiin manufacture proven how the LGE region was the main […]. ...
If you had a hospital infection or serious injury from contaminated injections, contact our lawyers for lawsuit info at (866) 920-0753.
Heart disease is directly associated with the cardiorespiratory and cardiovascular systems. One of the primary signs of heart and lung diseases include becoming winded with mild exertion. Individuals with heart or lung disease often become fatigued when performing day to day tasks that most of us take for granted. Aerobic exercise can help increase the bodys utilization of oxygenated blood pumping throughout the body, thus making our bodies stronger and more efficient performing everyday activities.. Im often asked what are the most important tips I can give for aerobic conditioning. I find myself continuously telling clients and friends three very important factors that will help to improve ones cardiovascular health. These factors include: know your target heart rate zone, know your intensity level, and be consistent.. 1. Know your target heart rate zone.. Your target heart rate zone is the number of beats per minute (bpm) at which your heart should be beating during aerobic exercise in ...
A stress echocardiogram is an ultrasound of the heart done before and after exercise to see the patients heart muscle function.
Introduction. The Critical Illness Research Group (GREPAC) aims at contributing to elucidate the mechanism involved in the onset and progression of different illnesses that cause a reversible dysfunction to one or more organs placing the patients life at risk. To do this, our research includes clinical research on patients, and also experimental models. These models allow us to study the molecular mechanisms involved in these processes and to identify therapeutic targets and new strategies against these illnesses and, whenever possible, to anticipate ourselves to these cascades to avoid more illnesses and multi-organ dysfunction. ...
Stress electrocardiogram - Tests how your heart reacts when youre physically exerting yourself.. Choose Spire Tunbridge Wells Hospital.
Dobutamine. The effects of beta-agonists such as dobutamine can be reversed by administering beta-blockers such as propranolol ... Lexiscan (Regadenoson) or Dobutamine is often used in patients with severe reactive airway disease (asthma or COPD) as ... The patient is subjected to stress in the form of exercise or chemically (usually dobutamine). After the target heart rate is ... or positive chronotropic agents such as dobutamine can be used. Testing personnel can include a cardiac radiologist, a nuclear ...
β1 selective: dobutamine. β2 selective: salbutamol/albuterol, terbutaline, salmeterol, formoterol, pirbuterol. These are agents ...
In normal hearts it increases the consumption of oxygen and energy to the same degree as dobutamine but in diseased hearts it ... Comparison with dobutamine." Circulation. 1992 Oct;86(4):1291-301. Goto Y1, Hata K. Mechanoenergetic effect of pimobendan in ...
Bhatt-Mehta V, Nahata MC (1989). "Dopamine and dobutamine in pediatric therapy". Pharmacotherapy. 9 (5): 303-14. doi:10.1002/j. ...
Bhatt-Mehta, Varsha; Nahata, Milap C. (1989-09-10). "Dopamine and Dobutamine in Pediatric Therapy". Pharmacotherapy: the ...
Other examples include phenylephrine, isoproterenol, and dobutamine. Stimulation of the D1 receptor by dopaminergic agonists ...
Examples include denopamine, dobutamine, xamoterol, and epinephrine. Epinephrine is a non-selective beta agonist, this means it ...
ISBN 978-1-85233-617-2.. Elhendy et al., Dobutamine Stress Myocardial Perfusion Imaging in Coronary Artery Disease, J Nucl Med ... Elhendy, A; Bax, JJ; Poldermans, D (2002). "Dobutamine stress myocardial perfusion imaging in coronary artery disease". Journal ... dobutamine, or dipyridamole (aminophylline can be used to reverse the effects of dipyridamole). SPECT imaging performed after ...
Elhendy A, Bax J, Poldermans D (2002). "Dobutamine Stress Myocardial Perfusion Imaging in Coronary Artery Disease*". J Nucl Med ... dobutamine or dipyridamole (aminophylline can be used to reverse the effects of dipyridamole). SPECT imaging performed after ...
Other drugs: digoxin, ranitidine, lenalidomide, methyldopa, interleukin 2, dobutamine, acetazolamide. Contaminants: ...
Common vasopressors used in shock include: norepinephrine, phenylephrine, dopamine, dobutamine. There is no evidence of ...
Cardiac failure manifests a weak contractibility myocardium; treatment with an inotropic drug such as dobutamine may be ...
It is also a positional isomer of dobutamine, a related drug. When used as a food additive, ractopamine added to feed can be ...
Use in sepsis has been explored in clinical trials, but use of an inotropic agent like dobutamine or dopexamine did not reduce ... Use of dopexamine may be harmful in sepsis Lisbon A (May 2003). "Dopexamine, dobutamine, and dopamine increase splanchnic blood ... It is not used often, as more established drugs like epinephrine, dopamine, dobutamine, norepinephrine, and levosimendan work ... dobutamine, norepinephrine, and levosimendan. It should not be used in people taking monoamine oxidase inhibitors, nor in ...
Dobutamine is not used as often as epinephrine due to its associated side effects, which include reducing blood flow to the gut ... Dobutamine can also be used in hypotensive septic shock to increase cardiac output and correct blood flow to the tissues. ... Additionally, dobutamine increases the cardiac output by abnormally increasing the heart rate. The use of steroids in sepsis is ... 2017). "The spectrum of cardiovascular effects of dobutamine - from healthy subjects to septic shock patients". Revista ...
Incremental value of strain rate imaging to wall motion analysis for prediction of outcome in patients undergoing dobutamine ... Automated analysis of myocardial deformation at dobutamine stress echocardiography: an angiographic validation. J Am Coll ... Strain-rate imaging during dobutamine stress echocardiography provides objective evidence of inducible ischemia. Circulation. ...
Norepinephrine and dobutamine cannot be used as additives in an intravenous sodium bicarbonate solution. Intravenous sodium ...
In these cases, high-dose dobutamine may be used to chemically increase heart rate. If dobutamine is insufficient for this ... Dipyridamole is an alternative to dobutamine but it is less effective in detecting abnormalities. While exercise ...
"Hemodynamic Comparison of Intravenous Amrinone and Dobutamine in Patients With Chronic Congestive Heart Failure". American ...
"Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial". The Lancet. 370 ( ...
However, the drug was proven to be superior to dobutamine for treating patients with a history of CHF or those on beta-blocker ... May 2007). "Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE Randomized Trial". JAMA ... in plasma B-type natriuretic peptide level in patients in the levosimendan group compared with patients in the dobutamine group ...
It is also critical that the dobutamine challenge be used, elevating the heart rate, because dFFR decreases significantly at ... IVUS cardiac catheterization including dFFR measured during dobutamine challenge - from which readings of dFFR and percentage ... Fractional flow reserve with dobutamine challenge and coronary microvascular endothelial dysfunction in symptomatic myocardial ... "Importance of diastolic fractional flow reserve and dobutamine challenge in physiologic assessment of myocardial bridging". ...
January 2005). "Risk stratification of women with peripartum cardiomyopathy at initial presentation: a dobutamine stress ...
Echocardiography: A wall motion abnormality at rest which improves during a low-dose dobutamine stress test is classified as " ... An alternative (or additional) technique with CMR is the use of low dose dobutamine similar to echocardiography. PET: The ... "hibernating myocardium." Low dose dobutamine stimulates contractile function and thus helps to predict functional recovery ...
Other treatments may include the use of dobutamine or in those with low blood volume, intravenous fluids. Those with few ...
113-. ISBN 978-1-4939-0002-2. Nordin, A. J.; Mäkisalo, H.; Höckerstedt, K. A. (1996-08-31). "Failure of dobutamine to improve ...
Comparison of two-dimensional speckle and tissue Doppler strain measurement during dobutamine stress echocardiography: an ...
Some centers use inotrope dobutamine to stress the heart and the images are interpreted in a similar fashion to dobutamine ... 2007). "Prognostic value of cardiac magnetic resonance stress tests: adenosine stress perfusion and dobutamine stress wall ...
"Functional and metabolic evaluation of the athlete's heart by magnetic resonance imaging and dobutamine stress magnetic ...
Alternatively, dobutamine stress echocardiography (DSE) is commonly performed and has an 85% sensitivity for the presence of ... and non-invasive investigations including dobutamine stress echocardiography, positron emission tomography, computed ...
A list of US medications equivalent to Dobutamine is available on the Drugs.com website. ... Dobutamine is a medicine available in a number of countries worldwide. ... Dobutamine. In the US, Dobutamine (dobutamine systemic) is a member of the following drug classes: cardiac stressing agents, ... DOBUTAMINE 12.5 MG/ML CONCENTRATE FOR SOLUTION FOR INFUSION. (Leaflet). *DOBUTAMINE 12.5MG/ML CONCENTRATE FOR SOLUTION FOR ...
A dobutamine stress echocardiogram (DSE) is a test performed to evaluate the heart. The test involves an echocardiogram, which ... is an ultrasound of your heart, an electrocardiogram (ECG) and the use of a medication, called dobutamine. ... Dobutamine Stress Echocardiogram. A dobutamine stress echocardiogram (DSE) is a test performed to evaluate the heart. The test ... Dobutamine Stress Echocardiogram Corrigan Minehan Heart Center 55 Fruit Street Boston, MA 02114 ...
a dobutamine stress echocardiogram is another form of stress echocardiogram. however, instead of exercising to stress the heart ... What is a dobutamine stress echocardiogram?. ANSWER A dobutamine stress echocardiogram is another form of stress echocardiogram ...
A list of US medications equivalent to Hospira Dobutamine HCl is available on the Drugs.com website. ... Hospira Dobutamine HCl is a medicine available in a number of countries worldwide. ... Dobutamine. Dobutamine hydrochloride (a derivative of Dobutamine) is reported as an ingredient of Hospira Dobutamine HCl in the ... Hospira Dobutamine HCl may be available in the countries listed below.. Ingredient matches for Hospira Dobutamine HCl. ...
Helping you find trustworthy answers on Dobutamine , Latest evidence made easy ... Find all the evidence you need on Dobutamine via the Trip Database. ... Dobutamine vs Adenosine CMR Study Dobutamine vs Adenosine CMR Study Dobutamine vs Adenosine CMR Study - Full Text View - ... Dobutamine stress echocardiography or dobutamine 99mTc-sestamibi SPECT? Both dobutamine stress echocardiography (DSE) and ...
"Dobutamine (Dobutrex) Use During Pregnancy". Drugs.com. 18 March 2020. Retrieved 17 May 2020. "Dobutamine Hydrochloride ... The most dangerous side effect of dobutamine is increased risk of arrhythmia, including fatal arrhythmias. Dobutamine is a ... Dobutamine is a medication used in the treatment of cardiogenic shock and severe heart failure. It may also be used in certain ... Dobutamine also has mild β2 agonist activity, which makes it useful as a vasodilator. It was developed in the 1970s by Drs. ...
Read the side effects of Dobutamine as described in the medical literature. In case of any doubt consult your doctor or ... Side effect(s) of Dobutamine Read the side effects of Dobutamine as described in the medical literature. In case of any doubt ... Dobutamine - Information. Dobutamine is a sympathomimetic compound used in the treatment of heart failure and cardiogenic shock ...
University Health Network►Peter Munk Cardiac Centre►Patients & Families►Clinics, Inpatient Units & Tests►Dobutamine Stress ... To "stress" the heart, youll be given an intravenous medication (Dobutamine) that will make your heart beat harder and faster ... A dobutamine stress echo is performed by a sonographer and interpreted by a cardiologist. ​​. ...
... , Stress Imaging with Dobutamine, Pharmacologic Stress Test with Dobutamine. ... Dobutamine Echocardiogram. Aka: Dobutamine Echocardiogram, Stress Imaging with Dobutamine, Pharmacologic Stress Test with ...
Find the most comprehensive real-world treatment information on Dobutamine at PatientsLikeMe. 1 patients with fibromyalgia, ... bipolar I disorder or psoriasis currently take Dobutamine. ... Dobutamine is an adrenergic agonist. It stimulates the ... What is Dobutamine?. Category: Prescription Drugs false ...
Join researchers using high quality Dobutamine hydrochloride from… ... Buy Dobutamine hydrochloride (CAS 49745-95-1), a beta-1 and beta-2 adrenoceptor agonist. ... Dobutamine: development of a new catecholamine to selectively increase cardiac contractility.. Circ Res 36:185-96 (1975). Read ... Role of endothelium and K+ channels in dobutamine-induced relaxation in rat mesenteric artery.. Clin Exp Pharmacol Physiol 25: ...
... dobutamine hydrochloride injection injection, solution), including warnings and precautions, directions, and the names of other ...
The double product changed with dobutamine from 8844 +/- 6000 to 15201 +/- 3030. The peak dose of dobutamine induced a small ... High doses of dobutamine, therefore, produce a small but significant decrease in potassium.(ABSTRACT TRUNCATED AT 250 WORDS). ... The test consisted of an intravenous infusion of dobutamine, starting with a dose of 5 micrograms/kg/min for 5 minutes and ... Changes in plasma potassium during the dobutamine stress test.. Coma-Canella I1. ...
Dobutamine is a drug that acts on the sympathetic nervous system. Physicians use it to treat heart failure and cardiogenic ... Dopamine and dobutamine are both substances that have important actions on our bodies. Both act at specific cell receptors and ... The result of dobutamines action on the body is an increase in the action of muscle cells in the heart and blood vessels. ... Dobutamine acts on adrenergic receptors, mostly on cells in the heart or on blood vessels. It stimulates those cells and causes ...
Dobutamine Injection. Products Affected - Description. * *Dobutamine injection, Pfizer, 12.5 mg/mL, 20 mL vial, 1 count, NDC ... Baxter has dobutamine injection available.. *Pfizer has dobutamine on shortage due to manufacturing delays. The latex-free ... Pfizer has dobutamine 12.5 mg/mL 20 mL vials in 1 count available in limited supply. The 12.5 mg/mL 20 mL vials in 10 count are ... Dobutamine injection, Baxter, 1 mg/mL, 250 mL premixed bag, 12 count, NDC 00338-1073-02 ...
We performed two dobutamine stress echocardiographic studies (dobutamine up to 40 micrograms/kg/min and atrop ... The aim of this study was to investigate the temporal variability and interobserver agreement of dobutamine digital stress ... We performed two dobutamine stress echocardiographic studies (dobutamine up to 40 micrograms/kg/min and atropine up to 1 mg) in ... Dobutamine / diagnostic use*. Echocardiography*. Female. Heart Rate / drug effects. Humans. Image Processing, Computer-Assisted ...
Drug Information on dobutamine includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and ... You should not use dobutamine if you are allergic to it.. To make sure dobutamine is safe for you, tell your doctor if you have ... FDA pregnancy category B. Dobutamine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to ... It is not known whether dobutamine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are ...
This topic contains 1 study abstract on Dobutamine indicating it may contribute to Cardiovascular Diseases, Drug Induced ... 1 Abstracts with Dobutamine Research. Filter by Study Type. In Vitro Study. ...
Dobutamine stress echocardiogram - Cardiac ultrasound scan to assess the response of your heart to stress. Learn about costs, ... A Dobutamine stress echocardiogram is a type of cardiac ultrasound scan to assess the response of your heart to exercise or ... A dobutamine stress echocardiogram is a type of cardiac ultrasound scan to assess the response of your heart to exercise or ... Once the resting echocardiogram has been done a drug called dobutamine will be given through a vein in your arm. This medicine ...
Canadian regulations limit the scope of information we are permitted to give on prescription drugs via the Internet or other means. Please consult a qualified health professional for more detailed information.Please contact Pfizer Canada Medical Information at 1 800 463-6001 with any comments or inquiries.If you encounter technical difficulties in viewing our product
... dobutamine. Tuttle, a pharmacologist, and Mills, a chemist, modified the structure of isoprenaline to obtain... ... Dobutamine has also a mild ß2 agonist activity, making it useful as a vasodilator Dobutamine increases the automaticity of the ... Dobutamine has no effect on the HV interval. Besides an increase in the heart rate, dobutamine induces ventricular premature ... Effects of dobutamine in patients with acute myocardial infarction. Am J Cardiol. 1977;139:588-94.CrossRefGoogle Scholar ...
Intravenous dobutamine 3 hours infusion of dobutamine. Drug: 3 hours intravenous dobutamine Intravenous dobutamine will be ... The Hemodynamic Response to Prolonged Dobutamine Infusion. The safety and scientific validity of this study is the ... Dobutamine. Cardiotonic Agents. Sympathomimetics. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects of ... Our hypothesis is that constant 3 hours intravenous infusion of the selective beta1 adrenergic receptor agonist dobutamine will ...
DBL Dobutamine Hydrochloride Injection (Concentrate for infusion) - Consumer Medicines Information leaflets of prescription and ... You must not be given DBL™ Dobutamine Hydrochloride Injection if you have an allergy to dobutamine or any of the ingredients ... How DBL™ Dobutamine Hydrochloride Injection is given. How much is given. Your doctor will decide what dose of dobutamine you ... DBL™ Dobutamine Injection is not recommended in children as the safety and effectiveness of dobutamine in children have not ...
Nevertheless, dobutamine remains the first-line inotropic treatment. Dobutamine has a positive chronotropic effect that might ... Drug Information available for: Norepinephrine Dobutamine Dobutamine hydrochloride Genetic and Rare Diseases Information Center ... Active Comparator: Norepinephrine plus Dobutamine Administration of norepinephrine and dobutamine. Drug: Norepinephrine After ... or dobutamine. There is a wash-out phase of 30 minutes (decrease of norepinephrine dose or weaning of dobutamine). The third ...
Dobutamine hydrochloride, mimics the effects of dopamine and stimulates beta-1 adrenergic receptors located in the myocardium. ... The hydrochloride salt form of dobutamine, a synthetic catecholamine with direct inotropic activity. ... Dobutamine Hydrochloride. Known as: dobutamine hcl, Dobutamine Hydrochloride [Chemical/Ingredient], hcl dobutamine Expand. ... The hydrochloride salt form of dobutamine, a synthetic catecholamine with direct inotropic activity. Dobutamine hydrochloride, ...
Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial.. Annane D1, Vignon ... At day 28, there were 64 (40%) deaths in the epinephrine group and 58 (34%) deaths in the norepinephrine plus dobutamine group ... There is no evidence for a difference in efficacy and safety between epinephrine alone and norepinephrine plus dobutamine for ... We aimed to compare the efficacy and safety of norepinephrine plus dobutamine (whenever needed) with those of epinephrine alone ...
... in a 50-year-old woman undergoing dobutamine stress echocardiography, of the simultaneous onset of complete left bundle branch ... Previous Document: Safety of dobutamine stress echocardiography in patients with unruptured intracranial aneurysms.. Next ... We report on the observation, in a 50-year-old woman undergoing dobutamine stress echocardiography, of the simultaneous onset ... 18489947 - Usefulness of cardiac magnetic resonance imaging combined with low-dose dobutamine stre.... 12422157 - Assessment of ...
Dobutamine stress echocardiogram - Cardiac ultrasound scan to assess the response of your heart to stress.. Choose Spire Clare ... A Dobutamine stress echocardiogram is a type of cardiac ultrasound scan to assess the response of your heart to exercise or ... A dobutamine stress echocardiogram is a type of cardiac ultrasound scan to assess the response of your heart to exercise or ... Once the resting echocardiogram has been done a drug called dobutamine will be given through a vein in your arm. This medicine ...
Dobutamine stress echocardiography (DSE), like exercise echocardiography, has found its primary application in ischemic heart ... Performing stress echocardiography with a pharmacologic agent such as dobutamine allows for simulation of increased heart rate ... Keywords: stress echocardiography, dobutamine, coronary artery disease, myocardial ischemia ... Dobutamine stress echocardiography: a review and update Lauren Gray Gilstrap,1 R Sacha Bhatia,2 Rory B Weiner,3 David M ...
  • Dobutamine stress-induced ischemic right ventricular dysfunction in patients with three-vessel coronary artery disease Dobutamine stress echocardiography (DSE) is a non-invasive technique to detect coronary artery diseases (CAD). (tripdatabase.com)
  • Cardiac stress imaging for the prediction of very long-term outcomes: Dobutamine stress echocardiography or dobutamine 99mTc-sestamibi SPECT? (tripdatabase.com)
  • Dobutamine stress echocardiography or dobutamine 99mTc-sestamibi SPECT? (tripdatabase.com)
  • Both dobutamine stress echocardiography (DSE) and myocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) are frequently used for cardiac risk stratification. (tripdatabase.com)
  • Reproducibility of dobutamine digital stress echocardiography. (biomedsearch.com)
  • The aim of this study was to investigate the temporal variability and interobserver agreement of dobutamine digital stress echocardiography. (biomedsearch.com)
  • Although dobutamine digital stress echocardiography has good reproducibility and negligible interobserver variability, even if the digital quad screen format is used, it requires strict standardization of the reading criteria and the objective measurements of wall motion in the expansion of this test to the evaluation of the changes in left ventricular function during more than two serial studies in the same patient. (biomedsearch.com)
  • Painful left bundle branch block detected during dobutamine stress echocardiography. (biomedsearch.com)
  • We report on the observation, in a 50-year-old woman undergoing dobutamine stress echocardiography, of the simultaneous onset of complete left bundle branch block and anginal chest pain, unaccompanied by any abnormality of left ventricular segmental contraction or wall thickening. (biomedsearch.com)
  • Safety of dobutamine stress echocardiography in patients with unruptured intracranial aneurysms. (biomedsearch.com)
  • Performing stress echocardiography with a pharmacologic agent such as dobutamine allows for simulation of increased heart rate and increased myocardial physiologic demands in patients who may be unable to exercise due to musculoskeletal or pulmonary comorbidities. (dovepress.com)
  • Dobutamine stress echocardiography (DSE), like exercise echocardiography, has found its primary application in ischemic heart disease, with roles in identification of obstructive epicardial coronary artery disease, detection of viable myocardium, and assessment of the efficacy of anti-ischemic medical therapy in patients with known coronary artery disease. (dovepress.com)
  • Dobutamine stress echocardiography is a common test to provoke myocardial ischemia in patients unable to undergo routine exercise stress testing. (witpress.com)
  • Conclusions PESP echocardiography is a useful and cost-effective method to identify viable myocardium in patients with multivessel coronary disease undergoing revascularization and is more sensitive and accurate than dobutamine infusion. (ahajournals.org)
  • Coronary Spasm after Administration of Propranolol during Dobutamine Stress Echocardiography]. (curehunter.com)
  • We report the case of a 37-year-old man with rest angina, repolarization abnormalities in precordial leads and normal coronary arteries who was referred for dobutamine - atropine stress echocardiography, which was negative for ischemia . (curehunter.com)
  • Role of low‑dose dobutamine echocardiography in predicting response to biventricular pacing. (nih.gov)
  • Cardiac dyssynchrony indices and low-dose dobutamine response were determined by echocardiography prior to CRT. (nih.gov)
  • The predictive value of LVEF gain at Dobutamine Stress Echocardiography (DSE) study was only significant at 6 months, with all-cause death occurring in 1 (1.6%) and 7 (12.1%) of patients with viable and non-viable myocardium respectively (p=0.029). (nih.gov)
  • van Loon RB, Veen G, Heymans MW, van Rossum AC (2012) Viability Tested with Dobutamine Stress Echocardiography and Prognosis Early after Acute Myocardial Infarction: A Meta-Analysis. (omicsonline.org)
  • Viability-testing with Low Dose Dobutamine echocardiography (LDDE) can safely be performed in the early phase after AMI. (omicsonline.org)
  • Dobutamine stress echocardiography (DSE) is a useful technique for screening. (cun.es)
  • Background Whether beta-blockade affects the sensitivity of dobutamine stress echocardiography for the diagnosis of coronary artery disease has been controversial. (onlinejacc.org)
  • A standard protocol of dobutamine stress echocardiography was first performed. (onlinejacc.org)
  • The goal of this trial was to evaluate echocardiographic image quality with and without echo contrast in patients undergoing dobutamine echocardiography. (acc.org)
  • Echo contrast will be more effective in showing endocardial borders and enhancing interpretation of dobutamine echocardiography. (acc.org)
  • A total of 101 patients undergoing stress testing were randomized to dobutamine echocardiography with Definity contrast and at least 4 hours later without contrast. (acc.org)
  • Among patients with intermediate to high risk of coronary artery disease, the use of contrast during dobutamine echocardiography improved the visualization of myocardial segments both at rest and peak stress. (acc.org)
  • Although contrast improved the detection of coronary disease, there were still 32% of patients with discordance results between dobutamine echocardiography and coronary angiography. (acc.org)
  • However, dobutamine stress echocardiography (DSE) and vasodilator myocardial perfusion imaging have comparable characteristics. (acpjc.org)
  • Less data is available for the comparison of dobutamine stress cardiac magnetic resonance (DSCMR) and dobutamine stress echocardiography (DSE) even though DSE is among the most frequently used tests in stable chest pain patients, especially in Europe. (onlinejacc.org)
  • Objective: Our purpose was to assess the value of second harmonic imaging compared with fundamental imaging for the diagnosis of coronary artery disease during dobutamine stress echocardiography. (eur.nl)
  • Patients and Methods: Sixty-four patients underwent dobutamine stress echocardiography with both fundamental imaging and second harmonic imaging. (eur.nl)
  • Ischemia was defined as new or worsening wall motion abnormalities in ≤1 segment during dobutamine stress echocardiography. (eur.nl)
  • 05). Conclusion: The use of second harmonic imaging improves the sensitivity of dobutamine stress echocardiography for the diagnosis of coronary artery disease compared with fundamental imaging, particularly for 1-vessel coronary artery disease, whereas specificity remains unchanged. (eur.nl)
  • Utility of dobutamine stress echocardiography in Kawasaki dise. (mysciencework.com)
  • Utility of dobutamine stress echocardiography in Kawasaki disease: a case report and review of the literature. (mysciencework.com)
  • Dobutamine stress echocardiography (DSE) has become widely accepted in the evaluation of adult patients with coronary heart disease. (mysciencework.com)
  • Dobutamine stress echocardiography (DSE) allows the distinction to be made between fixed low-flow/low-gradient (LF/LG) AS and pseudosevere AS. (icr-heart.com)
  • Bansal, M and Jeffriess, L and Leano, R and Mundy, J and Marwick, TH, Assessment of myocardial viability at dobutamine echocardiography by deformation analysis using tissue velocity and speckle-tracking, JACC: Cardiovascular Imaging, 3, (2) pp. 121-131. (edu.au)
  • Objectives Comparison of myocardial tissue-velocity imaging (TVI) and speckle-tracking echocardiography (STE) for prediction of viability at dobutamine echocardiography (DbE). (edu.au)
  • A continuous infusion of a single high dose of dobutamine has been, recently, suggested as a simple and effective protocol of stress echocardiography. (biomedcentral.com)
  • Two hundred sixty five consecutive patients underwent accelerated dobutamine stress echocardiography: the dobutamine was administered at a constant dose of 50 μg/kg/min for up to 10 minutes. (biomedcentral.com)
  • Our data demonstrate that a continous infusion of a single high dose of dobutamine is a safe and well tolerated method of performing stress echocardiography in patients with suspected or known coronary artery disease. (biomedcentral.com)
  • The aim of the study was to assess the value of dobutamine stress echocardiography in predicting the clinical course following coronary artery bypass grafting (CABG) in patients with ischaemic left ventricular dysfunction. (viamedica.pl)
  • Resting echocardiography and a small-dose (5-10 µg/kg/min) dobutamine test were performed before the procedure. (viamedica.pl)
  • A dobutamine stress echocardiogram (DSE) is a test performed to evaluate the heart. (massgeneral.org)
  • The test involves an echocardiogram, which is an ultrasound of your heart, an electrocardiogram (ECG) and the use of a medication, called dobutamine. (massgeneral.org)
  • What is a dobutamine stress echocardiogram? (webmd.com)
  • A dobutamine stress echocardiogram is another form of stress echocardiogram. (webmd.com)
  • A Dobutamine stress echocardiogram is a type of cardiac ultrasound scan to assess the response of your heart to exercise or stress. (spirehealthcare.com)
  • A dobutamine stress echocardiogram is a diagnostic procedure that may be used when a doctor wants to assess the heart muscle under stress. (nyhq.org)
  • There may be other reasons for your doctor to recommend a dobutamine stress echocardiogram. (nyhq.org)
  • Certain factors or conditions may interfere with a dobutamine stress echocardiogram. (nyhq.org)
  • I have a dobutamine echocardiogram stress test scheduled for 8am and drank a diet coke. (healthtap.com)
  • The dobutamine stress echocardiogram (DSE) assesses your heart and its function. (nm.org)
  • A dobutamine stress echocardiogram (DSE) may be used if you are unable to exercise. (rumcsi.org)
  • Why might I need a dobutamine stress echocardiogram? (rumcsi.org)
  • Dobutamine is administered via intravenous access for inotropic support in decompensated congestive heart failure and stress echocardiogram testing. (statpearls.com)
  • A Dobutamine Stress Echocardiogram is a procedure that involves the use of dobutamine, a medication that increases heart rate. (thavc.com)
  • Your doctor may choose to conduct a Dobutamine Stress Echocardiogram if he needs to see how your heart responds to stress, and exercise is not deemed a plausible or safe method. (thavc.com)
  • Note: It is generally advised that you avoid any caffeinated products or cigarettes before a Dobutamine Stress Echocardiogram. (thavc.com)
  • Is it necessary for me to do a Dobutamine Stress echocardiogram? (restoreheartcentre.com.sg)
  • We performed serial determinations of levels of potassium in 198 patients with suspected or proven coronary arterial disease who underwent a dobutamine stress test, so as to investigate if the depression in the ST segment induced by the test may be due to hypokalemia. (nih.gov)
  • Dobutamine increases regional myocardial blood flow but at a dose of 20 μg/kg/min induces coronary flow heterogeneity less than that induced by Dipyridamole or Adenosine. (springer.com)
  • Real-time MR image acquisition during high-dose dobutamine hydrochloride stress for detecting left ventricular wall-motion abnormalities in patients with coronary arterial disease. (semanticscholar.org)
  • Myocardial metabolic and hemodynamic effects of dobutamine in heart failure complicating coronary artery disease. (ahajournals.org)
  • Keeping these considerations in perspective, we have tested the diagnostic accuracy of an "accelerated" dobutamine stress echocardiographic procedure in patients with suspected coronary artery disease. (bmj.com)
  • The present study was performed to determine the accuracy of PESP, dobutamine, or their combination in identifying the reversible contractile dysfunction of hibernating myocardium and in predicting improvement after coronary artery bypass surgery. (ahajournals.org)
  • 2. Six conscious dogs received dobutamine, 1.56 × 10 −8 mol min −1 kg −1 , intravenously for a 7 day period and seven conscious dogs were given dobutamine, 1.51 × 10 −8 mol min −1 kg −1 , into the left coronary artery under oral propranolol treatment for the same period while arterial pressure, cardiac output (electromagnetic flowmeter) and heart rate were measured. (portlandpress.com)
  • Conclusions A correlation between regional wall thickening and coronary flow per heartbeat was demonstrated during baseline dobutamine stress. (onlinejacc.org)
  • The mechanisms by which beta-blockade prevents dobutamine-induced ischemia appeared to be mainly through decreases in heart rate and rate of rise in left ventricular pressure, improvement of regional coronary flow per heartbeat and attenuation of regional ischemic lactate production. (onlinejacc.org)
  • What are the sensitivity and specificity of dobutamine stress myocardial perfusion imaging (DSMPI) for detecting coronary artery disease (CAD)? (acpjc.org)
  • Dobutamine stress myocardial perfusion imaging has high sensitivity and moderate specificity for detecting coronary artery disease. (acpjc.org)
  • This study aims to assess the ability of intravenous ivabradine to decrease sinus tachycardia associated with dobutamine infused for LCOS after coronary artery bypass graft (CABG) surgery. (springermedizin.de)
  • Dobutamine can be used as temporary intravenous inotropic support until resolution of the acute inducing factors or the patient receives more definitive treatment, such as coronary revascularization, mechanical circulatory support, or heart transplant. (statpearls.com)
  • The present study assesses the feasibility, safety, and tolerability of an accelerated dobutamine stress protocol performed in patients with suspected or known coronary artery disease. (biomedcentral.com)
  • Read the side effects of Dobutamine as described in the medical literature. (medindia.net)
  • What are the possible side effects of dobutamine? (emedicinehealth.com)
  • Inotropic and cronotropic effects of dobutamine and isoproterenol on cat atria and papillary muscles at different temperatures (abstr). (springer.com)
  • Effects of dobutamine on electrophysiological properties of the specialized conduction system in man. (springer.com)
  • Effects of dobutamine on splanchnic tissue perfusion during partial superior mesenteric artery occlusion. (semanticscholar.org)
  • To separate the two mechanisms, we compared the effects of dobutamine with those of sodium nitroprusside on V O 2 / D O 2 relationships in healthy volunteers. (portlandpress.com)
  • 5. It is concluded that β-adrenergic cardiac effects of dobutamine are essential to the development of hypertension and increased peripheral resistance after prolonged intracoronary infusion of this drug. (portlandpress.com)
  • Dobutamine is used to treat acute but potentially reversible heart failure, such as which occurs during cardiac surgery or in cases of septic or cardiogenic shock, on the basis of its positive inotropic action. (wikipedia.org)
  • Dobutamine is predominantly a β1-adrenergic agonist, with weak β2 activity, and α1 selective activity, although it is used clinically in cases of cardiogenic shock for its β1 inotropic effect in increasing heart contractility and cardiac output. (wikipedia.org)
  • Nevertheless, dobutamine remains the first-line inotropic treatment. (clinicaltrials.gov)
  • The hydrochloride salt form of dobutamine, a synthetic catecholamine with direct inotropic activity. (semanticscholar.org)
  • Dobutamine exerts positive inotropic effect on the myocardium by stimulating β 1 -adrenergic receptors, thereby increasing myocardial contractility, stroke vol and cardiac output. (mims.com)
  • On the other hand, in spite of the important decrease in systolic capacity, dogs with doxorubicin-induced cardiomyopathy seem to respond to inotropic challenge of dobutamine. (vin.com)
  • Zurück zum Zitat El Mokhtari NE, Arlt A, Meissner A, Lins M. Inotropic therapy for cardiac low output syndrome: comparison of hemodynamic effects of dopamine/dobutamine versus dopamine/dopexamine. (springermedizin.de)
  • Dobutamine can reasonably be given in continuous intravenous form for inotropic support to bridge patients with late-stage heart failure, stage D, that is refractory to guideline-directed medical therapy until patients who are candidates for and awaiting cardiac transplantation or mechanical circulatory support receive the appropriate long-term treatment. (statpearls.com)
  • Continuous intravenous inotropic dobutamine support can reasonably be given in the short-term for those hospitalized patients with severe systolic dysfunction and presenting with a low blood pressure and a cardiac output that is significantly decreased, to preserve systemic blood flow and protect from end-organ damage. (statpearls.com)
  • Continuous intravenous inotropic dobutamine support can reasonably be given for the long-term in palliative patients with late-stage heart failure, stage D, who are not candidates for mechanical circulatory support or cardiac transplantation for symptomatic control, regardless of guideline-directed medical therapy. (statpearls.com)
  • Dobutamine is used as a pharmacological agent because of its inotropic effects on the myocardium through binding and activating the beta 1 receptors. (statpearls.com)
  • For hemodynamically unstable patients with AV block, intravenous dopamine or dobutamine should be started to improve chronotropic and inotropic cardiac function. (medscape.com)
  • Dobutamine in 5% Dextrose Injection, USP is indicated when parenteral therapy is necessary for inotropic support in the treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures. (themedidex.com)
  • Local dermal hypersensitivity from dobutamine hydrochloride (Dobutrex solution) injection. (semanticscholar.org)
  • Two patients had local dermal hypersensitivity at the site of dobutamine hydrochloride (Dobutrex solution) injection. (semanticscholar.org)
  • Dobutamine Hydrochloride In Dextrose, Dobutrex (dobutamine) is a small molecule pharmaceutical. (biometadata.com)
  • Dobutamine (Dobutrex) is a synthetic adrenergic agonist structurally similar to isoproterenol working on the same receptor profile - primarily beta 1 and beta 2 - to create the net effect of increased chronotropy (heart rate), inotropy (contractility) and vasodilation (decreased afterload). (rk.md)
  • Baxter has dobutamine injection available. (ashp.org)
  • This leaflet answers some common questions about DBL™ Dobutamine Hydrochloride Injection. (mydr.com.au)
  • Your doctor has weighed the risks of you being given DBL™ Dobutamine Hydrochloride Injection against the benefits they expect it will have for you. (mydr.com.au)
  • DBL™ Dobutamine Hydrochloride Injection is used in patients who require short-term treatment of heart failure following a heart attack or heart surgery. (mydr.com.au)
  • DBL™ Dobutamine Hydrochloride Injection acts directly on the heart muscle to increase the force of each contraction. (mydr.com.au)
  • Ask your doctor if you have any questions about why DBL™ Dobutamine Hydrochloride Injection has been prescribed for you. (mydr.com.au)
  • There is no evidence that DBL™ Dobutamine Hydrochloride Injection is addictive. (mydr.com.au)
  • You must not be given DBL™ Dobutamine Hydrochloride Injection if you have an allergy to dobutamine or any of the ingredients listed at the end of this leaflet. (mydr.com.au)
  • DBL™ Dobutamine Injection is not recommended in children as the safety and effectiveness of dobutamine in children have not been established. (mydr.com.au)
  • If you are not sure whether you should be given DBL™ Dobutamine Hydrochloride Injection, talk to your doctor or pharmacist. (mydr.com.au)
  • DBL™ Dobutamine Hydrochloride Injection is not recommended for use during pregnancy. (mydr.com.au)
  • It is not known whether DBL™ Dobutamine Hydrochloride Injection passes into breast milk. (mydr.com.au)
  • If you have not told your doctor or pharmacist about any of the above, tell them before you start being given DBL™ Dobutamine Hydrochloride Injection. (mydr.com.au)
  • These medicines may be affected by DBL™ Dobutamine Hydrochloride Injection, or may affect how well it works. (mydr.com.au)
  • Your doctor and pharmacist may have more information on medicines to be careful with or avoid while being given DBL™ Dobutamine Hydrochloride Injection. (mydr.com.au)
  • As DBL™ Dobutamine Hydrochloride Injection is given to you under the supervision of your doctor, it is very unlikely that you will receive too much. (mydr.com.au)
  • The FDA warned that an injection of particulates in dobutamine could cause local inflammation, vein inflammation (phlebitis), obstruction of small capillaries, and more. (schmidtlaw.com)
  • To determine whether there are differences in increase in longitudinal relaxation rate (DeltaR1) in the myocardium between bolus administration of Mn(2+) ions during rest and during dobutamine-induced stress and, additionally, to determine whether there are differences in DeltaR1 between bolus injection and infusion of Mn(2+) ions during dobutamine-induced stress. (diva-portal.org)
  • The animals in groups 2 and 3 were subjected to dobutamine stress before injection of MnCl(2), while those in group 1 were not given dobutamine. (diva-portal.org)
  • A significant difference in DeltaR1 between the groups with and the group without dobutamine stress was noted in the myocardium up to 45 minutes after contrast agent injection. (diva-portal.org)
  • Dobutamine Injection, USP is a clear, practically colorless, sterile, nonpyrogenic solution of dobutamine hydrochloride for intravenous use only. (pfizermedicalinformation.com)
  • Dobutamine in 5% Dextrose Injection, USP is a sterile, nonpyrogenic, prediluted solution of dobutamine hydrochloride and dextrose in water for injection. (themedidex.com)
  • Dobutamine in 5% Dextrose Injection, USP is oxygen sensitive. (themedidex.com)
  • Dobutamine in 5% Dextrose Injection, USP is administered intravenously through a suitable intravenous catheter or needle. (themedidex.com)
  • The test consisted of an intravenous infusion of dobutamine, starting with a dose of 5 micrograms/kg/min for 5 minutes and continuing with 10, 15, 20 and up to 40 micrograms/kg/min every 5 minutes (mean peak dose = 20 micrograms/kg/min). (nih.gov)
  • Effect of a 30-minute infusion of dobutamine hydrochloride on hind limb blood flow and hemodynamics in halothane-anesthetized horses. (semanticscholar.org)
  • All dogs underwent echocardiographic evaluation before (1) and during the infusion of dobutamine in increasingly doses: (2) 10 ug/kg/min. (vin.com)
  • Six horses were anaesthetised on two separate occasions at least 3 weeks apart and received either intravenous infusion of dobutamine alone or dobutamine infusion with a 20 ml/kg bwt bolus of Hartmanns solution. (horsetimesegypt.com)
  • Infusion of dobutamine should be started at a low rate (0.5 to 1.0 µg/kg/min) and titrated at intervals of a few minutes, guided by the patient's response, including systemic blood pressure, urine flow, frequency of ectopic activity, heart rate, and (whenever possible) measurements of cardiac output, central venous pressure, and/or pulmonary capillary wedge pressure. (themedidex.com)
  • Does Dobutamine Stress Perfusion Imaging Solve the Riddle of Ischemia in LBBB? (onlinejacc.org)
  • In addition to high-dose dobutamine wall motion imaging, they assessed first-pass perfusion during an intermediate dose of dobutamine (20 μg dobutamine/kg body weight/min) and the presence of scar tissue by late gadolinium enhancement (LGE) CMR. (onlinejacc.org)
  • This is further improved by adding perfusion imaging at 20 μg dobutamine/kg body weight and LGE. (onlinejacc.org)
  • Thus, in patients with LBBB, a "comprehensive CMR" examination that includes dobutamine stress wall motion, first-pass perfusion imaging at an intermediate dobutamine dose, and LGE appears to be an excellent test to detect significant CAD and seems to overcome some of the limitations that methods which rely only on wall motion (DSCMR and particularly DSE) have in this population. (onlinejacc.org)
  • Head-to-head comparison of first-pass MR perfusion imaging during adenosine and high-dose dobutamine/atropine stress. (uzh.ch)
  • To directly compare the stressor capabilities of adenosine and high-dose dobutamine/atropine using first pass myocardial perfusion magnetic resonance imaging. (uzh.ch)
  • On day 2, the identical CMR perfusion sequence was repeated during a standard high-dose dobutamine/atropine stress protocol at rest and during target heart rate (85% of maximum age-predicted heart rate). (uzh.ch)
  • Adenosine and dobutamine stress CMR perfusion imaging resulted in an equally high sensitivity and specificity for the stenosis detection on a per patient basis (92 and 75% for both stressors, respectively). (uzh.ch)
  • Adenosine and dobutamine/atropine stress CMR perfusion imaging are equally capable to identify stress inducible deficits and resulted in an almost identical extent of ischemic reactions. (uzh.ch)
  • Though adenosine stress CMR perfusion imaging is widely employed, dobutamine stress CMR perfusion represents a valid alternative and may be particularly useful in patients with contraindications to vasodilator testing. (uzh.ch)
  • Nephrology Now » Blog Archive » Comparison of the prognostic value of dipyridamole and dobutamine myocardial perfusion scintigraphy in hemodialysis patients. (nephrologynow.com)
  • Comparison of the prognostic value of dipyridamole and dobutamine myocardial perfusion scintigraphy in hemodialysis patients. (nephrologynow.com)
  • However, there was no significant difference in femoral blood flow measurements (a proxy measurement of peripheral perfusion) when dobutamine only was administered. (horsetimesegypt.com)
  • In isoflurane-anaesthetised horses, dobutamine administration alone causes an increase in cardiac index and oxygen delivery index, but a combination of dobutamine and crystalloid fluid bolus achieves significant improvements in femoral blood flow, providing evidence that this approach improves peripheral perfusion. (horsetimesegypt.com)
  • Dobutamine is an adrenergic agonist. (patientslikeme.com)
  • Dobutamine acts on adrenergic receptors, mostly on cells in the heart or on blood vessels. (livestrong.com)
  • Our hypothesis is that constant 3 hours intravenous infusion of the selective beta1 adrenergic receptor agonist dobutamine will result in gradual decline in hemodynamic responses to dobutamine over time. (clinicaltrials.gov)
  • 1. We have studied whether the progressive rise in peripheral resistance observed in response to chronic intracoronary administration of dobutamine in conscious dogs could have resulted from extracardiac or non-β-adrenergic cardiac effects of the drug. (portlandpress.com)
  • Objectives This study was designed to examine the effects of a beta-adrenergic blocking agent on the ischemic response to dobutamine stress and to determine the degree to which these effects can be abolished by the addition of atropine. (onlinejacc.org)
  • Your doctor or pharmacist will discuss the possible risks and benefits of being given dobutamine while you are breast-feeding. (mydr.com.au)
  • This study asked whether providing concurrent fluid support improved cardiovascular status in horses given dobutamine under anaesthesia. (horsetimesegypt.com)
  • Dobutamine can be used in cases of congestive heart failure to increase cardiac output. (wikipedia.org)
  • Dobutamine is a direct-acting agent whose primary activity results from stimulation of the β1-adrenoceptors of the heart, increasing contractility and cardiac output. (wikipedia.org)
  • To compare the hemodynamic effects of isoproterenol, dopamine, and dobutamine in the immature animal, each drug was infused into anesthetized open chest puppies and cardiac output was measured, as were systemic arterial blood pressure, heart rate, and renal artery blood flow. (ovid.com)
  • Cardiac output was increased by dopamine and dobutamine. (ovid.com)
  • 3. Intravenous dobutamine produced no increase in arterial pressure, but a decrease in peripheral resistance and an increase in cardiac output which persisted until the end of the infusion. (portlandpress.com)
  • Dobutamine is used to increase cardiac output in infants and children with circulatory failure. (qxmd.com)
  • Supranormal cardiac output in the dopamine- and dobutamine-dependent preterm infant. (qxmd.com)
  • As an anesthesiologist, I most often use dobutamine during heart transplant cases as these patients tend to have some combination of right heart dysfunction and initially decreased compliance which makes cardiac output more dependent on the heart rate. (rk.md)
  • Dobutamine was administered intravenously at an initial dose of 20 μg/kg/min that was maintained over three minutes. (bmj.com)
  • Dobutamine is administered intravenously to strengthen the heart muscle of patients with heart failure. (schmidtlaw.com)
  • Dobutamine comes in a solution as a racemic mixture of both positive and negative enantiomers that is then administered intravenously. (statpearls.com)
  • Next, you will be administered dobutamine intravenously (the doputamine dose will increase throughout the procedure, as determined by your doctor), and electrodes and gel will be applied to your chest. (thavc.com)
  • Instead of exercising on the treadmill, dobutamine will be given to you intravenously to make your heart pump as hard as if you were exercising. (restoreheartcentre.com.sg)
  • Whether given orally, continuously intravenously, or intermittently intravenously, neither dobutamine nor any other cyclic-AMP-dependent inotrope has been shown in controlled trials to be safe or effective in the long-term treatment of congestive heart failure. (themedidex.com)
  • The most dangerous side effect of dobutamine is increased risk of arrhythmia, including fatal arrhythmias. (wikipedia.org)
  • Oxytocin may possibly enhance the pressor effect of dobutamine w/ or w/o HTN. (mims.com)
  • Beta blockers may negate the effect of dobutamine. (unboundmedicine.com)
  • Dobutamine is a medication used in the treatment of cardiogenic shock and severe heart failure. (wikipedia.org)
  • To "stress" the heart, you'll be given an intravenous medication (Dobutamine) that will make your heart beat harder and faster just like it would during exercise. (uhn.ca)
  • Dobutamine may also be used for purposes not listed in this medication guide. (emedicinehealth.com)
  • If exercise on a treadmill is not an option (too much stress on the heart) due to a person's medical condition, a doctor may use an intravenous medication called dobutamine. (nyhq.org)
  • A Dobutamine Stress Echo is a stress echo test that involves the infusion of a medication called dobutamine, simulating the effects of exercise on your heart. (evergreenhealth.com)
  • An intravenous line (IV) will be inserted into a vein in your arm, so the dobutamine medication can be delivered directly into your bloodstream. (evergreenhealth.com)
  • Once the physician is present, the nurse will administer the dobutamine medication into the IV while the sonographer continues to obtain echo images periodically throughout the test. (evergreenhealth.com)
  • This stress can be triggered by exercise on a treadmill or if you are unable to exercise on a treadmill, with the help of a medication called dobutamine. (nm.org)
  • This is to allow Dobutamine medication to be given to you during the test. (restoreheartcentre.com.sg)
  • Dobutamine medication infusion will begin to be infused to you via the drip line. (restoreheartcentre.com.sg)
  • Occasionally, another medication (Atropine) may be given to increase your heart rate if Dobutamine is inadequate. (restoreheartcentre.com.sg)
  • The results of the dobutamine stress test have a more potent prognostic value than clinical or demographic parameters in predicting clinical improvement. (viamedica.pl)
  • We performed two dobutamine stress echocardiographic studies (dobutamine up to 40 micrograms/kg/min and atropine up to 1 mg) in 15 patients with previous myocardial infarction at a mean of 19 days apart. (biomedsearch.com)
  • Dobutamine infusion was prematurely stopped if one of the usual non-echocardiographic end points appeared. (bmj.com)
  • Echocardiographic assessment of cardiac function at rest and during dobutamine stress has direct clinical implications. (dissertations.se)
  • 3 Moreover, low-dose dobutamine infusion and PESP during 2D echocardiographic monitoring of LV function allow direct visualization of restoration of a normal contraction in asynergic myocardial regions. (ahajournals.org)
  • Aims To evaluate the additional value of dobutamine stress testing in patients with repaired tetralogy of Fallot (TOF) by relating stress imaging parameters at baseline to relevant parameters of clinical condition and right ventricular (RV) size during a serial follow-up. (eur.nl)
  • How likely am I to panic while having a dobutamine stress test? (healthtap.com)
  • Conclusion In a young TOF population, response to dobutamine stress was normal and remained stable during the 5-year follow-up. (eur.nl)
  • Ventricular tachycardia can be induced by dobutamine infusion in a small percentage of patients. (springer.com)
  • Esmolol prevented dobutamine-induced ischemia (lactate production and wall motion abnormalities) in seven of nine pigs. (onlinejacc.org)
  • You should not use this medicine if you have ever had an allergic reaction to dobutamine or to sulfites. (limamemorial.org)
  • 1 The standard protocol of dobutamine includes an initial dose of 10 μg/kg/min with increments of 10 μg/kg/min every three minutes up to 40 μg/kg/min which is maintained over six minutes and makes this procedure particularly long. (bmj.com)
  • Outpatient dobutamine for end-stage congestive heart failure. (semanticscholar.org)
  • The dobutamine-dopamine combination versus amrinone in congestive heart failure with a marked edematogenic sign complicated by functional kidney failure. (qxmd.com)
  • In 1975, Tuttle and Mills published an article on a new catecholamine discovered in 1970: dobutamine. (springer.com)
  • Dobutamine is a synthetic catecholamine used in the treatment of different cardiac pathologies associated with organic heart diseases, myocardial infarction and cardiac surgery. (brillonline.com)
  • Pfizer has dobutamine 12.5 mg/mL 20 mL vials in 1 count available in limited supply. (ashp.org)
  • Each milliliter contains 12.5 mg (41.5 µmol) dobutamine, as the hydrochloride and sodium metabisulfite, 0.2 mg added as antioxidant. (pfizermedicalinformation.com)
  • Systemic arterial mean blood pressure was increased by dopamine and dobutamine, but decreased by isoproterenol. (ovid.com)
  • Dopamine produced a significant increase of renal artery blood flow while renal artery blood flow was unchanged by dobutamine and decreased by isoproterenol. (ovid.com)
  • Dopamine and dobutamine may have potential advantages over isoproterenol in augmenting cardiovascular function in young animals. (ovid.com)
  • Dobutamine resembles dopamine chemically and is an analog of isoproterenol. (qxmd.com)
  • Acute hemodynamic effects of dopamine, dobutamine, and isoproterenol in congested infants or young children with large ventricular septal defect. (qxmd.com)
  • Dobutamine has a direct ß1 and ß2 stimulation effect with a dose-related increase in heart rate, myocardial contractility, and blood pressure. (springer.com)
  • Tuttle RR, Millis J. Dobutamine: development of a new cathecolamine to selectively increase the cardiac contractility. (springer.com)
  • Dobutamine is approved by the Food and Drug Administration (FDA) for short-term use in patients with decreased contractility due to heart failure or cardiac surgical procedures leading to cardiac decompensation. (statpearls.com)
  • Dobutamine increases contractility which leads to decreased end-systolic volume and therefore larger stroke volume. (statpearls.com)
  • Two factors were found to affect the prognosis adversely following CABG in both univariate and multivariate analysis: a history of hypertension (p = 0.039, OR 4.9, 95% CI 1.4-17.1) and lack of improvement in contractility in at least 4 segments during the dobutamine test (p = 0.0003, OR 37.2, 95% CI 6.3-218.4). (viamedica.pl)
  • Effects of intravenous home dobutamine in palliative end†stage heart failure on quality of life, heart failure hospitalization, and cost expenditure In patients with palliative end-stage heart failure, interventions that could provide symptomatic relief and prevent hospital admissions are important. (tripdatabase.com)
  • mortality, and cost expenditure.All consecutive end-stage heart failure patients not amenable for advanced therapies and discharged with continuous intravenous home dobutamine from a single tertiary centre between April 2011 and January 2017 were retrospectively analysed. (tripdatabase.com)
  • Dobutamine is a sympathomimetic compound used in the treatment of heart failure and cardiogenic shock. (medindia.net)
  • Dobutamine makes those cells contract faster and with a greater force, creating a higher heart rate and blood pressure. (livestrong.com)
  • Analysis of the wall motion was performed separately on the day after each dobutamine stress test (analysis A), and all images from the serial studies in the same patient were simultaneously retrieved and compared side-by-side in the same view (analysis B). The mean values of heart rate and blood pressure were comparable for each in the two studies except for the heart rate at rest. (biomedsearch.com)
  • Dobutamine stimulates heart muscle and improves blood flow by helping the heart pump better. (emedicinehealth.com)
  • Dobutamine is used short-term to treat cardiac decompensation due to weakened heart muscle. (emedicinehealth.com)
  • Dobutamine is usually given after other heart medicines have been tried without success. (emedicinehealth.com)
  • Besides an increase in the heart rate, dobutamine induces ventricular premature contractions in 3-15% of patients. (springer.com)
  • Leighton KM, Bruce C. Dobutamine and general anaesthesia: a study of the response of arterial pressure, heart rate and renal blood flow. (springer.com)
  • Comparative effects of prenalterol and dobutamine in a canine model of acute ischemic heart failure. (springer.com)
  • Dobutamine is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. (definitions.net)
  • Heart rate elevation, achieved by staged increases in dobutamine doses, acts as a surrogate for exercise. (witpress.com)
  • Dobutamine causes the heart to beat faster and will mimic the effects of exercise on the heart. (nyhq.org)
  • In this study, we examined the utility of preoperative dobutamine stress echocardiograms (DSE) obtained for 85 patients in accordance with guidelines published by the American College of Cardiology (ACC) and the American Heart Association (AHA). (nih.gov)
  • This study was a retrospective review of 85 patient charts that found a low cost-effectiveness of using American College of Cardiology/American Heart Association guidelines for obtaining preoperative dobutamine stress echocardiograms. (nih.gov)
  • Understand that Dobutamine will increase heart rate and may be perceived as a "stronger" heart beat. (healthtap.com)
  • Is it possible to die from a heart attack during a dobutamine stress test? (healthtap.com)
  • Dobutamine is a commonly used positive inotrope for the short-term management of heart failure. (semanticscholar.org)
  • Dobutamine is put in a vein and causes your heart to beat faster, to mimic how your heart is affected by exercise. (nm.org)
  • Dobutamine makes your heart beat harder and faster. (doylestownhealth.org)
  • It is normal for the heart muscle to squeeze faster and harder while getting the Dobutamine. (doylestownhealth.org)
  • When your heart has reached a certain rate and/or when the doctor has enough information, more nuclear imaging material will be given and the Dobutamine will be stopped. (doylestownhealth.org)
  • If your heart rate does not increase enough with the Dobutamine, you may be asked to do mild leg or arm exercises. (doylestownhealth.org)
  • Comparative effects of combined dopamine and nitroprusside versus dobutamine and nitroprusside infusions for computer-controlled management of low-output cardiac failure after open heart surgery. (qxmd.com)
  • Dobutamine is put in a vein and causes the heart to beat faster. (rumcsi.org)
  • The denervated donor heart does not receive vagal tone which modulates several aspects of cardiac function, so I need to use direct acting agents like dobutamine and epinephrine to achieve my goals. (rk.md)
  • Your Cardiologist will be able to assess how your heart pumps and how your heart valves function while your heart exercises under the influence of dobutamine infusion. (restoreheartcentre.com.sg)
  • However, Dobutamine may be associated with irregular heart rhythm, high blood pressure, low blood pressure or chest pain. (restoreheartcentre.com.sg)
  • Dobutamine administration produced a rapid increase in heart rate (9.4 ± 5.9 beats/min 2 ). (biomedcentral.com)
  • PURPOSE To determine the in vitro and in vivo antibacterial activity of a cardiovascular drug dobutamine hydrochloride. (semanticscholar.org)
  • Patients underwent cardiovascular magnetic resonance imaging to assess RV systolic and diastolic function at rest and during dobutamine stress. (eur.nl)
  • Left ventricular performance is routinely measured during dobutamine cardiovascular magnetic resonance (DCMR) and the stress induced left ventricular changes have been well described. (biomedcentral.com)
  • After normalization of the ischemic abnormalities elicited with this infusion, esmolol was infused at 50 μg/kg body weight per min and the dobutamine test was repeated, with 1.0 mg of atropine added at the maximal dobutamine dose. (onlinejacc.org)
  • Since it does not act on dopamine receptors to inhibit the release of norepinephrine (another α1 agonist), dobutamine is less prone to induce hypertension than is dopamine. (wikipedia.org)
  • The aim of this study was to compare hemodynamics and metabolics effects of 2 treatments strategies (norepinephrine dose increasing or addition of dobutamine) in patients with cardiogenic shock and optimised blood pressure level (MAP≥65 mmHg) under norepinephrine treatment. (clinicaltrials.gov)
  • Norepinephrine vs Norepinephrine and Dobutamine in Cardiogenic Shock : a Randomised, Opened, Cross-over Study. (clinicaltrials.gov)
  • After obtention of a mean arterial pressure (MAP) of 65 mmHg with infusion of norepinephrine, patients with cardiogenic shock receive for 3 hours either increasing doses of norepinephrine (with a maximal MAP of 85 mmHg) or dobutamine. (clinicaltrials.gov)
  • There is a wash-out phase of 30 minutes (decrease of norepinephrine dose or weaning of dobutamine). (clinicaltrials.gov)
  • Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial. (nih.gov)
  • We aimed to compare the efficacy and safety of norepinephrine plus dobutamine (whenever needed) with those of epinephrine alone in septic shock. (nih.gov)
  • Participants were assigned to receive epinephrine (n=161) or norepinephrine plus dobutamine (n=169), which were titrated to maintain mean blood pressure at 70 mm Hg or more. (nih.gov)
  • There is no evidence for a difference in efficacy and safety between epinephrine alone and norepinephrine plus dobutamine for the management of septic shock. (nih.gov)
  • Echocardiograms were obtained from three patients undergoing dobutamine stress tests. (witpress.com)
  • Dobutamine has also a mild ß2 agonist activity, making it useful as a vasodilator Dobutamine increases the automaticity of the sinoatrial node and decreases the refractory period of the atrium and atrio-ventricular node as well as the atrio-ventricular conduction time. (springer.com)
  • Dobutamine stress increases uptake of manganese ions in the myocardium. (diva-portal.org)
  • to MPI in patients unable to perform exercise testing.This prospective, single center study included 301 patients (mean age 59 ± 12 years, 56% men) unable to perform exercise tests who underwent DSE and dobutamine stress 99mTc-sestamibi MPI. (tripdatabase.com)
  • High doses of dobutamine, therefore, produce a small but significant decrease in potassium. (nih.gov)
  • The lower doses of dobutamine can be prescribed at 2.5 to 5.0 micrograms/kg/min, and the higher end of dobutamine doses can be 5.0 to 20.0 micrograms/kg/min. (statpearls.com)
  • What are the available doses of DOBUTamine Hydrochloride in Dextrose? (themedidex.com)
  • If overdose occurs, reduction or discontinuation of therapy is the only treatment necessary because of the short duration of dobutamine. (unboundmedicine.com)
  • Total duration of dobutamine infusion was 6.6 ± 2.1 min. (biomedcentral.com)
  • Dopamine and dobutamine are both substances that have important actions on our bodies. (livestrong.com)
  • Kinetic interactions of dopamine and dobutamine with human catechol- O -methyltransferase and monoamine oxidase in vitro. (springer.com)
  • Effects of dopamine and dobutamine on regional blood flow distribution in the neonatal piglet. (springer.com)
  • Parratt JR, Wainwright CL, Fagbemi O. Effect of dopexamine hydrochloride in the early stages of experimental myocardial infarction and comparison with dopamine and dobutamine. (springer.com)
  • Dopamine and dobutamine use in preterm or low birth weight neonates in the premier 2008 database. (qxmd.com)
  • Propranolol was infused after discontinuation of dobutamine. (bmj.com)
  • Dobutamine may be ineffective if beta-blockers Propranolol have recently been given. (vetstream.com)
  • 4. With propranolol treatment intracoronary dobutamine induced no significant haemodynamic changes but a short-lasting increase in mean arterial pressure and peripheral resistance. (portlandpress.com)
  • A dobutamine stress echo is performed by a sonographer and interpreted by a cardiologist. (uhn.ca)
  • If you are pregnant or suspect that you may be pregnant, you should notify your health care provider due to risk of injury to the fetus from a dobutamine stress echo. (nyhq.org)
  • Ultrasound images (Echo) will be taken before, during and after the dobutamine infusion. (evergreenhealth.com)
  • Objectives and Methodology: - To investigate regional myocardial linear deformations and torsion, at rest and in response to a dobutamine stress, in asymptomatic T2DM and SM patients without clinical complications, - to study the links between expected regional myocardial abnormalities and inflammation, hyperglycemia and cardiac adiposity. (centerwatch.com)
  • Adding atropine in conventional doses enhanced the ability of dobutamine stress to induce myocardial ischemia but did not completely abolish the effects of beta-blockade on either the severity of dobutamine-induced wall thickening abnormalities or regional metabolic disturbances. (onlinejacc.org)
  • Dobutamine has a positive chronotropic effect that might cause higher myocardial oxygen consumption. (clinicaltrials.gov)
  • Pharmacological stimulation from vasodilators such as dipyridamole or adenosine, or positive chronotropic agents such as dobutamine can be used. (wikipedia.org)
  • Intravenous dobutamine will be infused during 3 hours. (clinicaltrials.gov)
  • Intravenous dobutamine infusion typically begins at a dose of 5 mcg/kg/minute and can be titrated up to 20 mcg/kg/minute. (medscape.com)
  • Experience with intravenous dobutamine in controlled trials does not extend beyond 48 hours of repeated boluses and/or continuous infusions. (themedidex.com)
  • The patient is subjected to stress in the form of exercise or chemically (usually dobutamine). (wikipedia.org)
  • Dobutamine also has mild β2 agonist activity, which makes it useful as a vasodilator. (wikipedia.org)
  • Tuttle R.R. (1978) Chemistry and Pharmacology of Dobutamine. (springer.com)
  • Dobutamine administration can lead to possible adverse reactions, mainly due to the sympathomimetic activity. (statpearls.com)