Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Neoplasms containing cyst-like formations or producing mucin or serum.
Tumors or cancer of the SKIN.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancers of the KIDNEY.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the THYROID GLAND.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
DNA present in neoplastic tissue.
Tumors or cancer of the LUNG.
Tumors or cancer of the PAROTID GLAND.
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.
Tumors or cancer of the APPENDIX.
Tumors or cancer of the LIVER.
A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Tumors or cancer of the ENDOCRINE GLANDS.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.
Tumors or cancer of the EYE.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the NOSE.
Tumors or cancer of the SALIVARY GLANDS.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
A benign epithelial tumor with a glandular organization.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the UTERUS.
Tumors or cancer of the INTESTINES.
Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.
A general term for various neoplastic diseases of the lymphoid tissue.
Tumors or cancer located in bone tissue or specific BONES.
Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.
Neoplasms composed of more than one type of neoplastic tissue.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumors or cancer of the MANDIBLE.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Tumors or cancer of the BILE DUCTS.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the THYMUS GLAND.
Tumors or cancer of the SPLEEN.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)
Tumors or cancer of the COLON.
Cancer or tumors of the MAXILLA or upper jaw.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Tumors or cancer of the anal gland.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
Tumors or cancer of the DUODENUM.
Tumors or cancers of the ADRENAL CORTEX.
Tumors or cancer of the MOUTH.
Tumors or cancer of the MEDIASTINUM.
Tumors or cancer of the TONGUE.
Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).
Tumors or cancer of the STOMACH.
Tumors or cancer of the URINARY BLADDER.
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Tumors or cancer of the VAGINA.
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.
Experimentally induced tumors of the LIVER.
A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A malignant epithelial tumor with a glandular organization.
Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE DISORDERS.
Surgical removal of the pancreas. (Dorland, 28th ed)
Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)
Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.
Tumors or cancer of the PARANASAL SINUSES.
Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.
Tumors or cancer of the human BREAST.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
Neoplasms of the bony orbit and contents except the eyeball.
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc.
Tumors or cancer of the BRONCHI.
Tumors or cancer of the PERITONEUM.
Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of MACROPHAGES and DENDRITIC CELLS.
Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.
Neoplasms of the bony part of the skull.
Tumors or cancer of the VULVA.
Neoplasms composed of neuroepithelial cells, which have the capacity to differentiate into NEURONS, oligodendrocytes, and ASTROCYTES. The majority of craniospinal tumors are of neuroepithelial origin. (From Dev Biol 1998 Aug 1;200(1):1-5)
Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).
Tumors or cancer of the LIP.
A benign tumor of fibrous or fully developed connective tissue.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Tumors or cancer of the ADRENAL GLANDS.
Tumors or cancer of the pelvic region.
Tumors or cancer of the gallbladder.
The local implantation of tumor cells by contamination of instruments and surgical equipment during and after surgical resection, resulting in local growth of the cells and tumor formation.
Neoplasms composed of fibrous and epithelial tissue. The concept does not refer to neoplasms located in fibrous tissue or epithelium.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue.
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.
RNA present in neoplastic tissue.
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)
A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
Tumors or cancer of the CECUM.
A malignant disease of the B-LYMPHOCYTES in the bone marrow and/or blood.
A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
Tumors or cancer of the DIGESTIVE SYSTEM.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)
Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
Liquid material found in epithelial-lined closed cavities or sacs.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A benign epithelial tumor of the LIVER.
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.
A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption.
A condition characterized by poorly-circumscribed gelatinous masses filled with malignant mucin-secreting cells. Forty-five percent of pseudomyxomas arise from the ovary, usually in a mucinous cystadenocarcinoma (CYSTADENOCARCINOMA, MUCINOUS), which has prognostic significance. Pseudomyxoma peritonei must be differentiated from mucinous spillage into the peritoneum by a benign mucocele of the appendix. (Segen, Dictionary of Modern Medicine, 1992)
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Tumor or cancer of the MALE GENITALIA.
Intracranial tumors originating in the region of the brain inferior to the tentorium cerebelli, which contains the cerebellum, fourth ventricle, cerebellopontine angle, brain stem, and related structures. Primary tumors of this region are more frequent in children, and may present with ATAXIA; CRANIAL NERVE DISEASES; vomiting; HEADACHE; HYDROCEPHALUS; or other signs of neurologic dysfunction. Relatively frequent histologic subtypes include TERATOMA; MEDULLOBLASTOMA; GLIOBLASTOMA; ASTROCYTOMA; EPENDYMOMA; CRANIOPHARYNGIOMA; and choroid plexus papilloma (PAPILLOMA, CHOROID PLEXUS).
Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
Tumors of the iris characterized by increased pigmentation of melanocytes. Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. Malignant melanoma of the iris often originates from preexisting nevi.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Primary urethral carcinomas are rare and typically of squamous cells. Urethral carcinoma is the only urological malignancy that is more common in females than in males.
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
A family of mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. These cells do not have a normal anatomic homolog. (From Fletcher CDM, et. al., World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone, 2002).
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A mixed mesenchymal tumor composed of two or more mesodermal cellular elements not commonly associated, not counting fibrous tissue as one of the elements. Mesenchymomas are widely distributed in the body and about 75% are malignant. (Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
Tumors or cancer of the RECTUM.
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.
Tumors or cancer of the ESOPHAGUS.
Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A usually benign tumor made up predominantly of myoepithelial cells.
Tumors or cancer of the PROSTATE.
Tumors of cancer of the EYELIDS.
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Benign and malignant tumors of the HYPOTHALAMUS. Pilocytic astrocytomas and hamartomas are relatively frequent histologic types. Neoplasms of the hypothalamus frequently originate from adjacent structures, including the OPTIC CHIASM, optic nerve (see OPTIC NERVE NEOPLASMS), and pituitary gland (see PITUITARY NEOPLASMS). Relatively frequent clinical manifestations include visual loss, developmental delay, macrocephaly, and precocious puberty. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2051)
A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Tumors or cancer of the MAXILLARY SINUS. They represent the majority of paranasal neoplasms.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

The incorporation of 5-iodo-2'-deoxyuridine into the DNA of HeLa cells and the induction of alkaline phosphatase activity. (1/9730)

Inhibition of DNA synthesis during the period of exposure of HeLa cells to 5-iodo-2'-deoxyuridine (IUdR) inhibited the induction of alkaline phosphatase activity. This finding, taken together with previous findings that IUdR did not induce alkaline phosphatase activity in the presence of 2-fold molar excess thymidinemonstrated that IUdR incorporation into DNA is correlated with the increase in alkaline phosphatase activity. With the exception of an interim period described in the text, induction of alkaline phosphatase activity was linearly related to medium concentrations of IUdR of up to at least 3 muM. However, the extent of IUdR substitution in DNA did not appear to be related to the degree of enzyme induction. Alkaline phosphatase activity continued to increase at medium concentrations of IUdR from 1 to 3 muM, while little further substitution of DNA occurred.  (+info)

Action of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver. (2/9730)

The effects of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver were investigated. The enzyme was isolated from the nuclear fraction essentially according to the method of Baril et al.; it was characterized as the alpha polymerase on the basis of its response to synthetic templates and its inhibition with N-ethylmaleimide. Although polycytidylic acid had no effect on the DNA polymerase alpha either as a template or as an inhibitor, partially thiolated polycytidylic acid (MPC) was found to be a potent inhibitor, its activity being directly related to its extent of thiolation (percentage of 5-mercaptocytidylate units in the polymer). In comparison, the DNA polymerase beta which was purified from normal rat liver nuclear fraction, was much less sensitive to inhibition by MPC. Analysis of the inhibition of the alpha polymerase by the method of Lineweaver and Burk showed that the inhibitory action of MPC was competitively reversible with the DNA template, but the binding of the 7.2%-thiolated MPC to the enzyme was much stronger than that of the template (Ki/Km less than 0.03). Polyuridylic acid as such showed some inhibitory activity which increased on partial thiolation, but the 8.4%-thiolated polyuridylic acid was less active than the 7.2% MPC. When MPC was annealed with polyinosinic acid, it lost 80% of its inhibitory activity in the double-stranded configuration. However, 1 to 2%-thiolated DNA isolates were significantly more potent inhibitors than were comparable (1.2%-thiolated) MPC and showed competitive reversibility with the unmodified (but "activated") DNA template. These results indicate that the inhibitory activities of partially thiolated polynucleotides depend not only on the percentage of 5-mercapto groups but also on the configuration, base composition, and other specific structural properties.  (+info)

Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets. (3/9730)

A long-acting thymidine pellet consisting of 190 mg of cholesterol and 60 mg of thymidine has been developed for the study of thymidine metabolism and reutilization in vivo. Implantation of such a pellet s.c. in adult mice will maintain the blood plasma concentration of thymidine at levels between 40 and 8 X 10(-6) M, which are from 36 to 7 times those of normal mice, for periods up to 48 hr. During this period, in vivo uptake and reutilization of [125I]iododeoxyuridine, a thymidine analog, into intestinal and tumor DNA were almost completely suppressed. While iododeoxyuridine reutilization is not large in normal proliferative tissue even in the absence of pellet implants, reutilization of over 30% was measured in large, rapidly growing ascites tumors. The inhibition of iododeoxyuridine incorporation by elevated thymidine blood levels is directly proportional to serum concentration. This appears to be due to a thymidine pool in rapid equilibrium with blood thymidine. This pool is at least 10 times larger than the 4-nmole pool of extracellular thymidine.  (+info)

The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture. (4/9730)

We have established or characterized six lines of human breast cancer maintained in long-term tissue culture for at least 1 year and have examined these lines for estrogen responsiveness. One of these cell lines, MCF-7, shows marked stimulation of macromolecular synthesis and cell division with physiological concentrations of estradiol. Antiestrogens are strongly inhibitory, and at concentrations greater than 3 X 10(-7) M they kill cells. Antiestrogen effects are prevented by simultaneous treatment with estradiol or reversed by addition of estradiol to cells incubated in antiestrogen. Responsive cell lines contain high-affinity specific estradiol receptors. Antiestrogens compete with estradiol for these receptors but have a lower apparent affinity for the receptor than estrogens. Stimulation of cells by estrogens is biphasic, with inhibition and cell death at concentrations of 17beta-estradiol or diethylstilbestrol exceeding 10(-7) M. Killing by high concentrations of estrogen is probably a nonspecific effect in that we observe this response with 17alpha-estradiol at equivalent concentrations and in the otherwise unresponsive cells that contain no estrogen receptor sites.  (+info)

The effects of glucocorticoids and progesterone on hormone-responsive human breast cancer in long-term tissue culture. (5/9730)

Glucocorticoids, at physiological concentration, inhibit cell division and thymidine incorporation in three lines of human breast cancer maintained in long-term tissue culture. At steroid concentrations sufficient to inhibit thymidine incorporation 50%, little or no effect is seen on protein synthesis 48 hr after hormone addition. All three of these lines are shown to have glucocorticoid receptors demonstrable by competitive protein binding assays. Receptors are extensively characterized in one line by sucrose density gradient analysis and binding specificity studies. Good correlation between receptor-binding specificity and biological activity is found except for progesterone, which binds to glucocorticoid receptor but is noninhibitory. Cross-competition and quantification studies demonstrate a separate receptor for progesterone. This receptor has limited binding specificities restricted largely to progestational agents, whereas the glucocorticoid receptor bound both glucocorticoids and progesterone. Two other human breast cancer lines neither contain glucocorticoid receptor nor are inhibited by glucocorticoids. It is concluded that in some cases glucocorticoids can directly limit growth in human breast cancer in vitro without requiring alterations in other trophic hormones.  (+info)

The effects of androgens and antiandrogens on hormone-responsive human breast cancer in long-term tissue culture. (6/9730)

We have examined five human breast cancer cell lines in continuous tissue culture for androgen responsiveness. One of these cell lines shows a 2- to 4-fold stimulation of thymidine incorporation into DNA, apparent as early as 10 hr following androgen addition to cells incubated in serum-free medium. This stimulation is accompanied by an acceleration in cell replication. Antiandrogens [cyproterone acetate (6-chloro-17alpha-acetate-1,2alpha-methylene-4,6-pregnadiene-3,20-dione) and R2956 (17beta-hydroxy-2,2,17alpha-trimethoxyestra-4,9,11-triene-1-one)] inhibit both protein and DNA synthesis below control levels and block androgen-mediated stimulation. Prolonged incubation (greater than 72 hr) in antiandrogen is lethal. The MCF- cell line contains high-affinity receptors for androgenic steroids demonstrable by sucrose density gradients and competitive protein binding analysis. By cross-competition studies, androgen receptors are distinguishable from estrogen receptors also found in this cell line. Concentrations of steroid that saturate androgen receptor sites in vitro are about 1000 times lower than concentrations that maximally stimulate the cells. Changes in quantity and affinity of androgen binding to intact cells at 37 degrees as compared with usual binding techniques using cytosol preparation at 0 degrees do not explain this difference between dissociation of binding and effect. However, this difference can be explained by conversion of [3H]-5alpha-dihydrotestosterone to 5alpha-androstanediol and more polar metabolites at 37 degrees. An examination of incubation media, cytoplasmic extracts and crude nuclear pellets reveals probable conversion of [3H]testosterone to [3H]-5alpha-dihydrotestosterone. Our data provide compelling evidence that some human breast cancer, at least in vitro, may be androgen dependent.  (+info)

Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models. (7/9730)

In Sarcoma 180 and L1210 ascites tumor models, the initial rate of methotrexate accumulation in tumor cells in the peritoneal cavity and in small intestine (intracellularly) after s.c. doses up to 800 mg/kg, showed saturation kinetics. These results and the fact that initial uptake in these tissues within this dosage range was inhibited to the expected relative extent by the simultaneous administration of leucovorin suggest that carrier mediation and not passive diffusion is the major route of drug entry at these extremely high doses. Maximum accumulation of intracellular drug occurred within 2 hr and reached much higher levels in small intestine than in tumor cells at the higher dosages. At a 3-mg/kg dose of methotrexate s.c., intracellular exchangeable drug levels persisted more than four times longer in L1210 cells than in small intestine, but differences in persistence (L1210 cell versus gut) diminished markedly with increasing dosage. At 96 mg/kg, the difference in persistence was less than 2-fold. In small intestine and L1210 cells, theduration of inhibition of DNA synthesis at different dosages correlated with the extent to which exchangeable drug was retained. Toxic deaths occurred when inhibition in small intestine lasted longer than 25 to 30 hr. Recovery of synthesis in small intestine and L1210 cells occurred synchronously and only below dosages of 400 mg/kg. Within 24 hr after dosages of greater than 24 mg/kg, the rate of tumor cell loss increased to a point characterized by a single exponential (t1/2=8.5 hr). The total cell loss, but not the rate of cell loss, was dose dependent.  (+info)

Ambiguity of the thymidine index. (8/9730)

The observed thymidine indices of seven experimental tumor lines are compared as a function of duration of emulsion exposure. The effects of dose level of tritiated thymidine and background threshold are also evaluated. The results indicate that an arbitrary high background threshold discriminates against "lightly" labeled cells at short periods of exposure but that the chosen threshold becomes less critical with longer exposure. The observed thymidine index increases with increasing duration of emulsion exposure but appears to approach a plateau for all tumor systems. The "thymidine index curves" are significantly different for each tumor. There is an inverse relationship between the dose of tritiated thymidine and the duration of exposure required to recognize the same fraction of cells as labeled in a given tumor. Similar experimental conditions do not necessarily guarantee a valid basis for comparison of observed thymidine indices among tumors.  (+info)

IBMs Watson computing system will help to sequence the DNA of cancer tumours in order to treat glioblastoma, the most common type of brain cancer in US adults.
Scans of cancerous tumors offer limited information on gene mutations and inhibit doctors ability to target treatments, according to a new study.
In a buyout that marks the latest endorsement for targeted cancer drugs---and, potentially, the increasing utility of broad cancer DNA tests---Roche this m
Principal Investigator:TAKIHARA Hiroshi, Project Period (FY):1992 - 1993, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Urology
This pack is the DNA and DNA ladder refill for the HNPCC: Detecting Inherited Forms of Cancer CarolinaBLU™ Kit (item #214820). Pack does not come with any additional instructions or support material. It is designed to be used in conjunction with the kit.
BONUS points: Use a program like Powerpoint, Word, Illustrator, Microsoft Paint, etc. to illustrate how primers bind to the cancer DNA template, and how Taq polymerases amplify the DNA. Screen-captures from the OpenPCR tutorial might be useful. Be sure to credit the source if you borrow images.) ...
BONUS points: Use a program like Powerpoint, Word, Illustrator, Microsoft Paint, etc. to illustrate how primers bind to the cancer DNA template, and how Taq polymerases amplify the DNA. Screen-captures from the OpenPCR tutorial might be useful. Be sure to credit the source if you borrow images.) ...
The detection of tumor-derived cell-free DNA in plasma is one of the most promising directions in cancer diagnosis. The major challenge in such approach is how to identify the tiny amount of tumor DNAs out of total cell-free DNAs in blood. Here we propose an ultrasensitive cancer detection method, termed CancerDetector, using the DNA methylation profiles of cell-free DNAs. The key of our method is to probabilistically model the joint methylation patterns of multiple adjacent CpG sites on an individual sequencing read, in order to exploit the pervasive nature of DNA methylation for signal amplification. Therefore, CancerDetector can sensitively identify a trace amount of tumor cfDNAs in plasma, at the level of individual reads. We evaluated CancerDetector on the simulated data, and showed a high concordance of the predicted and true tumor burden. Testing CancerDetector on real plasma data demonstrated its high sensitivity and specificity in detecting tumor DNAs. In addition, the predicted tumor ...
However, ASCO also acknowledges that emerging technologies, like genomic profiling for low penetrance genetic variants (markers of very low disease risk), may be appropriate for some patients who do not have a personal or family history that suggests a higher risk of cancer. People may undergo genetic testing using direct-to-consumer (DTC) tests, but they may ask their health care providers for help in interpreting the test results and obtaining follow-up care. For any genetic test, ASCO urges doctors and other health care providers to recommend follow-up care that is based on established cancer risk factors such as family history, behavioral factors, environmental exposures, and scientifically-validated tests for cancer risks.. ASCO further states that although the list of genes for cancer susceptibility syndromes continues to grow, the ever-changing nature of the field highlights the importance of getting genetic counseling both before and after doing genetic testing. Companies that offer DTC ...
Clinical experience has shown that mammary carcinomas can be classified according to their type of progression into slow-growing and fast-growing ones, where the terms
Vical was developing a DNA vaccine for therapy of prostate cancer. The vaccine was in preclinical development in the USA when the programme was discontinued.
Plasma DNA was found to be more sensitive than CEA for detecting cancer that cannot be removed through a surgical procedure (100 percent versus 40 percent) and was also more sensitive than CEA in detecting recurrent esophageal cancer (100 percent versus 33 percent). All patients with recurrent disease had elevated plasma DNA, and no patient with normal plasma DNA had recurrent disease (i.e., there were no false positives or false negatives for plasma DNA). Plasma DNA rose before there was clinical evidence of recurrence in 67 percent of patients, versus 17 percent of patients measured for CEA ...
A recent review in Oncogene discusses how fasting may help patients who have been diagnosed with cancer. This is interesting, because at the moment most people are advised to eat extra calories and proteins while undergoing cancer treatments. It turns out that in animals fasting changes the physiology of the body and this can help protect normal cells from the damaging effects of anti-cancer agents. The amazing thing is that cancer cells are abnormal and dont get the same protection, so fasting seems to be a way to help normal cells and not help the targets of the treatment. It More ,. ...
article{28d6110c-5d57-42d8-9243-f7ea1c6d6398, abstract = {This analysis of DNA-ploidy heterogeneity in advanced gastric carcinomas is consistent with the hypothesis of the emergence of a single aneuploid cell clone as a crucial mechanism in the progression from early gastric carcinoma to advanced gastric cancer. The prognostic value of DNA-ploidy in gastric cancers has been a matter of controversy. Tumour DNA-ploidy heterogeneity, the presence within the same tumour of multiple stemlines differing in DNA content, has been described in various tumours including gastric cancers. The occurrence of such heterogeneity has been accepted as an explanation for the divergent DNA-ploidy results in this type of tumours. A previous study of early gastric cancers suggested that in pure diploid superficial carcinomas, genetic instability might lead to a cell clone which has undergone a ploidy shift and is more aggressive. If so, this would initially result in DNA-ploidy heterogeneity. Proliferative dominance ...
Dive into the research topics of A multifaced DNA ploidy analysis to determine ovarian carcinoma aggressiveness. Together they form a unique fingerprint. ...
DNA vaccination holds great promise for the prevention and treatment of cancer and infectious diseases. However, the clinical ability of DNA vaccines is still controversial due to the limited immune response initially observed in humans. We hypothesized that electroporation of a plasmid encoding the HIV-1 Gag viral capsid protein would enhance cancer DNA vaccine potency. DNA electroporation used to deliver plasmids in vivo, induced type I interferons, thereby supporting the activation of innate immunity. The coadministration of ovalbumin (OVA) and HIV-1 Gag encoding plasmids modulated the adaptive immune response. This strategy favored antigen-specific Th1 immunity, delayed B16F10-OVA tumor growth and improved mouse survival in both prophylactic and therapeutic vaccination approaches. Similarly, a prophylactic DNA immunization against the melanoma-associated antigen gp100 was enhanced by the codelivery of the HIV-1 Gag plasmid. The adjuvant effect was not driven by the formation of HIV-1 Gag ...
Authors: Abad, Mar , Ciudad, Juana , Rincon, Manuel R. , Silva, Isabel , Paz‐Bouza, José I. , Lopez, Antonio , Alonso, Alberto G. , Bullon, Agustin , Orfao, Alberto Article Type: Research Article Abstract: In the present study the prognostic value of both DNA ploidy and the proliferative activity of tomour cells were studied in a series of 76 consecutive patients suffering from gastric tumours. DNA ploidy and the proliferative index (as measured by the percentage of S‐phase cells) were determined by flow cytometry using fresh tumour specimens. The presence of DNA aneuploid clones by flow cytometry was detected in 62% of the cases (mean DNA index of 1.63\pm 0.46 ; range 1.08-2.92), the mean proportion of S‐phase cells being of 18.4\pm 11.5\% . In comparison with diploid cases, aneuploid tumours …showed a higher proliferative activity (cases with more than 15% S‐phase cells: 18.4% versus 6.1%, p=0.0001 ) as well as a higher incidence of node involvement (95% versus 68%, p=0.001 ). By ...
The E.Z.N.A.® SQ Tissue DNA Kit provides a reliable method for the isolation of high molecular weight genomic DNA from various types of fresh or frozen tissue samples. This solution based system can process single or multiple samples simultaneously in less than 90 minutes. Samples are lysed with WTL Buffer/Protease and cellular proteins are removed by precipitation. High molecular genomic DNA remains in solution and is purified by isopropanol precipitation. DNA purified using the E.Z.N.A.® SQ Tissue DNA Kit is free of contaminants and enzyme inhibitors making it suitable for downstream applications such as PCR, Southern blotting and restriction enzyme digestion.. ...
TY - JOUR. T1 - IL VALORE PROGNOSTICO DELLA PLOIDIA, DELLINDICE PROLIFERATIVO E DEI RECETTORI PER LEPIDERMAL GROWTH FACTOR NEL CANCRO DELLO STOMACO OPERATO. ANALISI DI 130 CASI. AU - Santoro, E.. AU - Zupi, G.. AU - Vecchione, A.. AU - Carboni, M.. AU - Carlini, M.. AU - Catarci, M.. AU - Giannarelli, D.. AU - DAgnano, I.. AU - Santoro, R.. AU - Garofalo, A.. PY - 1995. Y1 - 1995. N2 - DNA ploidy, proliferative index (PI) and EGF-R espression of 130 gastric adenocarcinomas submitted to surgical treatment during the last ten years, were evaluated and related to the usual prognostic variables, such as TNM, stage, grading and histology of the tumor. DNA ploidy and PI were obtained through flow cytometry whereas EGF-R was evaluated with immunostaining. Diploid tumors were observed in 52% of cases and aneuploid in the remaining 48%. Low PI was present in 58% and high PI in 42% of cases. EGF-R was expressed in 69% of cases. All the three biologic variables were significantly related to T and ...
The usage of circulating tumor DNA (ctDNA) being a novel and noninvasive test for the diagnosis and surveillance of cancer is a rapidly growing market, with sequencing of ctDNA acting being a potential surrogate for tissue biopsy. the purpose of early recognition, prognostic information, individualized therapy options, and monitoring for level of resistance or recurrence, all Fulvestrant inhibitor database with fewer or no tissues biopsies. Provided the latest first-ever FDA acceptance of a water biopsy, its important for clinicians to understand the rapid improvements likely to provide these lab tests into our procedures soon. Right here we review the biology, scientific implications, and latest developments in circulating tumor DNA evaluation. = 0.005 and = 0.006, respectively) [20]. For these good reasons, circulating DNA size profiling has been examined for addition in a verification blood check for cancers, since it distinguishes Fulvestrant inhibitor database early from past due ...
Liquid Biopsies To Find Circulating Tumor DNA,Characterizing and monitoring tumor genomes with blood samples could achieve significant improvements in precision medicine
A new study shows that there are regions of non-coding DNA that may have a connection to cancer growth and progression if altered.
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Looking for online definition of DNA ploidy analysis in the Medical Dictionary? DNA ploidy analysis explanation free. What is DNA ploidy analysis? Meaning of DNA ploidy analysis medical term. What does DNA ploidy analysis mean?
Background: DNA polymerases (Pols) represent potential candidates for cancer genes because of their central functions in DNA metabolism. Defects of some DNA Pols have shown cancer associations, but data on DNA polymerase (Pol) ε is limited. Materials and Methods: Twenty-four human breast cancer DNA samples and four control DNA samples were examined for possible mutation in the entire coding region of the 55 kDa small subunit of the human DNA Pol ε gene using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis of the DNA and sequence analysis. In addition, 20 control DNAs were studied with PCR-SSCP for the end of intron 18 and exon 19 region. Results: An AATT deletion was found at one location in intron 18 in 2 out of the 24 breast cancer cases (8%), but in none of the control cases. In addition, a single base transition was found in the cancer DNAs in intron 14, but the same changes were also found in the control DNAs, suggesting polymorphism. Conclusion: ...
|i|Background|/i|: C-Myc, a well-known oncogene located on 8q24.12–q24.23, is often amplified and over-expressed in both primary and metastasizing colorectal cancer. In addition, PRL-3 (also known as PTP4A3), a tyrosine phosphatase located on 8q24.3, is amplified in colorectal cancer metastasis. Beside PRL-3 and c-myc, other oncogenes located on the 8q23–24 region might be involved in this process. Therefore, the present study aims to correlate DNA copy number status of a series of genes at 8q23–24 in colorectal cancer at high resolution in correlation to metastatic disease. |i|Materials and Methods|/i|: Thirty-two cases of colorectal cancer, 10 stage B1, 10 B2 and 12 D (Astler–Coller) with their corresponding liver metastasis and one colorectal cell line (colo205, previously analyzed by array-CGH), were included in this study. A chromosome 8 specific MLPA probe mixture was used to analyze the presence of DNA copy number changes. The probe mixture contained 29 probes covering
BACKGROUND: Wilms tumour (WT) is the most common solid tumour affecting young children. Its histological diversity leads to difficulties in predicting the outcome. MATERIALS AND METHODS: Image analysis cytometry and immunohistochemistry with a selected panel of antibodies were performed in 23 cases of WT considered of intermediate risk according to the revised International Society of Pediatric Oncology (SIOP) working classification of renal tumours of childhood. In this series, a tumour was considered aggressive according to its propensity for metastases or its recurrence. RESULTS: Out of the 14 non-aggressive WT, 4 were found to be diploid and 10 were aneuploid including 6 that were heterogeneous for DNA-ploidy. All the tumours presented a low proliferative index and were negative for p53 and p57(kip2) immunostaining. Out of the 9 aggressive tumours, all were aneuploid and 4 were found to be heterogeneous for DNA-ploidy. They all presented a high degree of cell proliferation and 7 w
Cialis tadalafil 20mg - Metolazone potent diuretic may cause the disorder is tadalafil cialis 20mg a reliable siterectal, bladder, or bowel. In females . Male-to-female ratio. Tumor cell dna content is very high. Although its use is the childs way of osmotic shifts between the icu is indicated.
Background: DNA ploidy has been shown to have prognostic significance in patients with breast cancer. Studies in the past have mainly utilized flow cytometry (FCM) for measuring DNA ploidy. However FCM has several disadvantages, the instrument cannot distinguish benign from malignant cells and it cannot be performed on small tumor samples. The relationship between DNA ploidy and biomarker expression in breast cancer has not been well studied. Recently, gene expression analysis has demonstrated distinct subtypes of breast cancer. Expression of ER, PR and Her2 by IHC has been used as a surrogate tool for the molecular classification of breast cancer. Aim: To determine the relationship between DNA ploidy, biomarkers (ER, PR, HER2, Ki67 and p53) expression and molecular subtypes of invasive breast cancer (IBCA) using image analysis.. Design: DNA analysis was performed on Feulgen stained sections from the same tumor block used for biomarker analysis. DNA indices and ploidy were analyzed using the ...
The flow acetone staining technique (FAST) allows one to concurrently study physical cell features revealed by light‐scatter analysis, surface/nuclear phenotypes, and cellular DNA content
In multistep schemes, hydrophobic charge-induction chromatography (HCIC) has been shown to contribute effectively to clearance of Chinese hamster ovary (CHO) host-cell proteins (CHOPs), DNA, and viruses. When used for capture chromatography, HCIC can provide better aggregate clearance than protein A sorbents can. Chen et al. enhanced clearance of aggregates, CHOPs, and product- related impurities by controlling HCIC based on both pH and the presence of binding-promoting salt in the wash and elution buffers used (1). Taken together with our findings…. ...
Aneuploidy is a well recognised feature of human tumours, but the investigation of its biological and clinical significance has been hampered by technological constraints. Quantitative DNA analysis reflects the total chromosomal content of tumour cells and can now be determined rapidly and reliably using flow cytometry; this has resulted in renewed interest in its potential clinical applications. This article reviews the accumulating evidence that tumour ploidy reflects the biological behaviour of a large number of tumour types and that diploid tumours in particular have a relatively good prognosis. The measurement of tumour ploidy is likely to become a valuable adjunct to the clinical and histopathological assessment of cancers.. ...
Free Online Library: Rosiglitazone Role in the Expression of KLF6 Caco-2 Colon Cancer Cells/Rol de Rosiglitazona en la Expresion de KLF6 en Celulas Caco-2 de Cancer de Colon. by International Journal of Morphology; Biological sciences Antibodies Research Cancer research Cell differentiation Colon cancer DNA binding proteins Fluorescence microscopy Oncology, Experimental Thiazolidinediones Viral antibodies
Assay of cell-free DNA in blood offers an approach to assessment of tumor DNA. We sought to determine whether Epstein-Barr virus (EBV) DNA in cell-free blood is also a good surrogate for the presence of tumor DNA in children with Hodgkin lymphoma, as it is in adults, and whether it correlates with pediatric outcomes. Pediatric patients enrolled in a Childrens Oncology Group trial (AHOD0031) were studied at baseline and at 8 days after the initiation of treatment. At baseline, EBV DNA in cell-free blood correlated with the presence of EBV in tumor, and EBV DNA 8 days after the initiation of therapy predicted inferior event-free survival ...
16. Bu, D., C. M. Lewis, V. Sarode, M. Chen, X. Ma, A. M. Lazorwitz, R. Rao, M. Leitch, A. Moldrem, V. Andrews, A. Gazdar, and D. Euhus (2013). Identification of breast cancer DNA methylation markers optimized for fine-needle aspiration samples. eng. Cancer Epidemiol Biomarkers Prev 22(12), 2212-2221. PMID: 24089458. ...
16. Bu, D., C. M. Lewis, V. Sarode, M. Chen, X. Ma, A. M. Lazorwitz, R. Rao, M. Leitch, A. Moldrem, V. Andrews, A. Gazdar, and D. Euhus (2013). Identification of breast cancer DNA methylation markers optimized for fine-needle aspiration samples. eng. Cancer Epidemiol Biomarkers Prev 22(12), 2212-2221. PMID: 24089458. ...
Tissue DNA Extraction and Tissue RNA Isolation - Some animal and human tissues are the toughest samples to isolate high-quality DNA or RNA
Holden thinks more data will be required for a firm determination. The data need to go 15 years out to make recommendations confidently, and they dont, he says. Its an interim analysis and the task force is drawing its own conclusions. Most of its done with different kinds of health care systems and different types of populations and there are huge cultural differences.. For instance, he says, If you offer surveillance to a group of patients in Scandinavia for whatever criteria you think are appropriate for that recommendation, about 50 percent of them will take that option. In the United States, its about 9 percent.. New technology may ride to the rescue. For example, the PCF wants to see the development of a urine test resulting from specific prostate cancer DNA fusions in 2005 at the University of Michigan. The test detects two biomarkers prevalent in most prostate cancers.. PSA in the blood is not cancer-specific, but this new DNA diagnostic tool is, says Jonathan W. Simons, ...
The Diagnostic, Monitoring and Screening Test opportunities are explored. A revolution in cancer diagnostics is occurring using in vitro blood testing to identify cancer DNA. GRAIL, a new company with impressive backing, has announced a single blood test to detect all cancers. The technology is moving faster than the market. New technology that definitively identifies disease conditions from blood samples is poised to replace expensive invasive surgical biopsy procedures. The market is still in its infancy but has outstanding growth potential. The impact on the health care industry is enormous. The report forecasts the market size out to 2020. In addition, the report looks at potential market sizes by country, by cancer and by the three different opportunities: detection, management and screening. Use independent research that makes you the expert. Get our research team working for you by ordering all, or a portion, of this comprehensive report. Your credit card order sends the report to your ...
Mutant RAS has been identified in pancreas, colon, thyroid, bladder and ovarian cancers and is predictive of a very poor response to EGFR-inhibiting drugs.
Mutant RAS has been identified in pancreas, colon, thyroid, bladder and ovarian cancers and is predictive of a very poor response to EGFR-inhibiting drugs.
Uses of Flow Cytometry 1. Multicolour analysis Cell Cycle and Proliferation... 3 a. Analysis of Cellular DNA Content... 4 b. Cell Proliferation Assays Immunology Apoptosis... 7
High Molecular Weight DNA Markers from Invitrogen,High Molecular Weight DNA Markers are suitable for sizing linear double-stranded DNA from 9 to 48 kb on low-percentage agarose gels. The 13 bands consist of 8.3- to 48.5-kb fragments generated from restriction endonuclease digests of Lambda DNA (cIind1ts857 Sam7). Ethidium bromide staining causes t,biological,biology supply,biology supplies,biology product
|i|Background|/i|: the |i|ras|/i| oncogene mutations frequently occurred in acute myeloid leukemia (AML), but as a prognostic factor remains inconclusive. |i|Methods|/i|: The databases of PubMed, Web of Science, EMBASE, and the Cochrane. 22 eligible studies were included this study and analysis was conducted by Comprehensive Meta-Analysis Version 2 software program. All eligible studys quality assessment refers to the European Lung Cancer Party quality scale. |i|Results|/i|: Combined analysis showed that |i|ras|/i| oncogene mutation was a poor impact on survival in AML patients (Hazard ratios (HRs): 1.50, 1.19-1.89, |i|p|/i| |0.001). |i|Nras|/i| gene mutation was a worse survival marker in AML (HR: 1.97, 95% CI: 1.35-2.89, |i|p|/i| |0.001) and |i|Kras|/i| gene mutations was no significance (HR: 1.32, 95% CI: 0.83-2.09, |i|p|/i| =0.24) by stratified analysis. In the analysis of age bracket, adults with |i|ras|/i| gene mutation had an unfavorable survival (HR: 1.55, 95% CI: 1.19-2.21, |i|p|/i| =0.01) and
Flow cytometry is more and more widely used for investigations of cell death, predominantly in the study of DNA degradation in cells dying by apoptosis. There are different interpretations of changes observed in DNA histograms of these cells. We describe an approach based on extraction of chromatin degradation products from fixed cells and subsequent staining with DNA specific dyes. Apoptotic cells containing fragmented DNA are observed in , 2C DNA region of DNA histograms. DNA histograms of irradiated thymocytes dying in vitro and stained without extraction of fragmented DNA do not differ from control. Under the same staining conditions DNA histograms of lymphocytes dying in thymus of irradiated animals reveal fluorescent material in , 2C DNA region, most likely due to formation of apoptotic bodies (cell fragments, some of them contain fragments of nuclei). Similar changes are observed in thymocytes dying upon glucocorticoid treatment. Our present results and other data indicate that reduced ...
LOH and microsatellite alterations were observed in biopsy specimens from both current and former smokers, but no statistically significant differences were observed between the two groups. Among individuals with a history of smoking, 86% demonstrated LOH in one or more biopsy specimens, and 24% showed LOH in all biopsy specimens. About half of the histologically normal specimens from smokers showed LOH, but the frequency of LOH and the severity of histologic change did not correspond until the carcinoma in situ stage. A subset of biopsy specimens from smokers that exhibited either normal or preneoplastic histology showed LOH at multiple chromosomal sites, a phenomenon frequently observed in carcinoma in situ and invasive cancer. LOH on chromosomes 3p and 9p was more frequent than LOH on chromosomes 5q, 17p (17p13; TP53 gene), and 13q (13q14; retinoblastoma gene). Microsatellite alterations were detected in 64% of the smokers. No genetic alterations were detected in nonsmokers. Conclusions: ...
828 Small and large-scale chromosomal aberrations, including amplifications, deletions, and rearrangements, are commonly seen in solid tumors. In human colorectal cancer (CRC), amplification of chromosome regions 20q, 8q, 13q, 7p, 12p, and loss of 18q, 8p, 17p, 4p, and 15q are frequently observed. These regions harbor oncogenes, tumor suppressors, and DNA repair genes that are known to be involved in the etiology of the disease. A combined, high-resolution gene expression and DNA copy number approach has been applied to test the hypothesis that a more comprehensive measure of the genetic damage in CRC will reveal novel molecular targets. Here, microarrays consisting of ∼35,000 spotted oligonucleotides have been utilized to examine both gene expression and DNA copy number changes in primary colorectal tumors from patients with stage II-IV disease. A colorectal cancer tissue array containing approximately 100 CRC samples has been constructed for use in validation studies. To date, 50 primary CRC ...
TY - JOUR. T1 - Cell cycle analysis using flow cytometry. AU - Gray, J. W.. AU - Dolbeare, F.. AU - Pallavicini, M. G.. AU - Beisker, W.. AU - Waldman, F.. PY - 1986/1/1. Y1 - 1986/1/1. N2 - This manuscript reviews the utility of flow cytometry for the study of cell proliferation. The applications of univariate DNA distribution analysis to cytokinetic studies of asynchronous and perturbed cell populations are discussed briefly. The newly developed technique for simultaneous flow cytometric measurement of cellular DNA content and amount of incorporated bromodeoxyuridine is discussed in more detail. The cytochemistry required for this analysis is reviewed as are its applications to: (a) determination of the fractions of cells in the G1-, S- and G2 + M phases of the cell cycle; (b) determination of the G1-, S- and G2 + M phase durations and dispersions and growth fraction for asynchronous cells; (c) detection of ara-C resistant cells present at low frequency in an otherwise sensitive population; ...
iStat- Epigenetic IVD assay for cancer DNA methylation biomarkers. iStat is a Taiwan-based biotechnology company specialized in the development and manufacturing of high quality gene methylation assay products for the early detection of cervical, oral, and bladder cancers. The company provides innovative IVD products for use in the clinical laboratories and solutions for medication managements. The company is actively seeking distributors in Europe, Middle East, and Latin America, and is discussing licensing potentials with some of the global companies.
New revolutionary tests that can detect stray cancer cells in the blood are emerging as the latest and most innovative way to detect the presence of cancer much earlier than possible with previous mainstream testing.. Painful biopsies, visible signs of disease, mammogram, colonoscopy, and surgery have been the mainstay for screening and diagnosing cancer cells and determining treatment options. These methods have drawbacks, for example, the samples arent enough to identify the genes or pathways that command growth mechanisms and are often unavailable for an oncologist to examine between the time span of the test and the patients appointment.. Stanford University School of Medicine has developed the cancer personalized profiling by deep sequencing, CAPP-Seq, an new test for early detection that is unlike any other because it explores DNA to identify stray cancer cells as they float in the bloodstream. Remarkably, it can detect a single cancerous molecule of cancer DNA out of 10,000 healthy ...
The cell-free DNA (cfDNA) is always present in plasma, and it is biomarker of growing interest in prenatal diagnostics as well as in oncology and transplantology for therapy efficiency monitoring. But does this cfDNA have a physiological role? Here we show that cfDNA presence and clearance in plasma of healthy individuals plays an indispensable role in immune system regulation. We exposed THP1 cells to healthy individuals plasma with (NP) and without (TP) cfDNA. In cells treated with NP, we found elevated expression of genes whose products maintain immune system homeostasis. Exposure of cells to TP triggered an innate immune response (IIR), documented particularly by elevated expression of pro-inflammatory interleukin 8. The results of mass spectrometry showed a higher abundance of proteins associated with IIR activation due to the regulation of complement cascade in cells cultivated with TP. These expression profiles provide evidence that the presence of cfDNA and its clearance in plasma of healthy
In one case (#1251), SNV observed in the tumor DNA were not detected in plasma DNA. In another case (#1559), SNV were barely detectable (VAF of 0.5% for two variants). Of note, both cases displayed limited disease (stage I or II) and normal lactate dehydrogenase levels, indicating that the amount of tumor-specific circulating cfDNA is at least partially related to tumor burden. Despite a low amount of circulating DNA extracted from plasma for cases #1251 and #1559, we obtained adequate sequencing quality and depth (the overall number of reads sequenced with mutated targets was 4,685 and 51,195 respectively; Table 1), indicating that in some rare cases, tumor-specific cfDNA is absent or beneath the level of sensitivity of the NGS method used. Of note, in case #1631 characterized by limited stage I disease, SNV were detected with a mean VAF of 5.2% in plasma DNA, as compared to a mean VAF of 34.6% in the tumor DNA (Table 1). In contrast, cases #1639 and #1768 (both with stage IV disease and ...
Longitudinal multi-gene panel assessment of circulating tumor DNA revealed tumor burden and molecular characteristics along treatment course of non-small cell lung cancer
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This proposal is in response to NIDCR PAR-09-182 Small Grants for Data Analysis, to support research that involves secondary data analyses using existing oral h...
"DNA copy number losses in human neoplasms". The American Journal of Pathology. 155 (3): 683-94. doi:10.1016/S0002-9440(10)65166 ... Hofmann K (April 2009). "Ubiquitin-binding domains and their role in the DNA damage response". DNA Repair. 8 (4): 544-56. doi: ... Monoubiquitinated PCNA recruits polymerases that can carry out DNA synthesis with damaged DNA; but this is very error-prone, ... Ubiquitination of histone H2AX is involved in DNA damage recognition of DNA double-strand breaks. Lysine 63-linked ...
September 1999). "DNA copy number losses in human neoplasms". The American Journal of Pathology. 155 (3): 683-94. doi:10.1016/ ...
DNA binding. • protein dimerization activity. • transcription factor activity, sequence-specific DNA binding. • protein complex ... Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes. Ligand. Growth factors. ... Through its bHLH DNA-binding motif, Myc interacts with DNA, while the leucine zipper TF-binding motif allows the dimerization ... transcription, DNA-templated. • transcription from RNA polymerase II promoter. • G1/S transition of mitotic cell cycle. • ...
... transcribes viral RNA into the full length DNA complement. Rous P (September 1910). "A Transmissible Avian Neoplasm (Sarcoma of ... 4S RNA is the primer for RSV and 70S RNA serves as the template for DNA synthesis. Reverse transcriptase, an RNA-dependent DNA ... RSV is a class VI enveloped virus with a positive sense RNA genome having a DNA intermediate. RSV has four genes: gag - encodes ... Dahlberg JE, Sawyer RC, Taylor JM, Faras AJ, Levinson WE, Goodman HM, Bishop JM (May 1974). "Transcription of DNA from the 70S ...
This occurs through multiple mutations that affect the DNA-mismatch-repair pathways. As a consequence, DNA mutations during ... Paris classification of colorectal neoplasms. In colonoscopy, colorectal polyps can be classified by NICE (Narrow-band imaging ... The increased risk of cancer seen in patients with by the syndrome is associated with dysfunction of DNA repair mechanism. ... A neoplasm is a tissue whose cells have lost normal differentiation. They can be either benign growths or malignant growths. ...
DNA damage appears to be the primary underlying cause of cancer. If accurate DNA repair is deficient, DNA damages tend to ... Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms). Thus, CpG island hyper/hypo- ... and the insertion into a host DNA can produce DNA methylation and provoke a spreading into the Flanking DNA area. This ... Therefore, the DNA methylation can lead eventually to the noticeably loss of CpG sites in neighboring DNA. Previous studies ...
It can occur in small cell carcinomas and in some high-grade malignant neoplasms. The effect is well known in diagnostic ... Azzopardi was able to correctly characterize the effect as due to DNA; it had been thought previously but incorrectly to be ... Necrosis results in the release of cellular DNA, which adheres in patches to the walls of blood vessels, showing as intensely ... The Azzopardi phenomenon, or Azzopardi effect, is the presence of DNA in necrotic venules. ...
Sengupta K, Rao BJ (December 2002). "Translin binding to DNA: recruitment through DNA ends and consequent conformational ... These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Translin has been shown to ... Translin is a DNA-binding protein that in humans is encoded by the TSN gene. Together with translin-associated factor X, ... Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (January 2002). "DNA damage-dependent interaction of the nuclear matrix ...
Malignant neoplasms[edit]. DNA damage[edit]. The central role of DNA damage and epigenetic defects in DNA repair genes in ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... Deficiencies in DNA repair cause increased mutation rates.[34][35][36] A deficiency in DNA repair, itself, can allow DNA ... Bernstein C, Prasad AR, Nfonsam V, Bernstei H (2013). "DNA Damage, DNA Repair and Cancer". New Research Directions in DNA ...
Another component of the DNA repair machinery in the cell is the protein MLH1. Ablation of MLH1 in mice causes development of ... 1996). "Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice". Cancer Res. 56 (16): 3842-9. PMID 8706033 ... Thus, 8-OH-dG was increased, DNA repair protein ERCC1 was decreased, autophagy protein beclin-1 was increased and, in the stem ... Another gene involved in DNA mismatch repair is Msh6. Both the Msh6 and Msh2 mutant mice develop gastrointestinal cancer but ...
If accurate DNA repair is deficient, DNA damages tend to accumulate. Unrepaired DNA damage can increase mutational errors ... Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms). Thus, epigenetic downregulation or ... July 2007). "DNA damage, homology-directed repair, and DNA methylation". PLOS Genetics. 3 (7): e110. doi:10.1371/journal.pgen. ... Bernstein, C; Prasad, AR; Nfonsam, V; Bernstein, H. (2013). "Chapter 16: DNA Damage, DNA Repair and Cancer". In Chen, Clark (ed ...
Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms). Germ line mutations in DNA repair ... If DNA repair is deficient, DNA damage tends to accumulate. Such excess DNA damage can increase mutational errors during DNA ... Reduced DNA repair likely allows accumulation of DNA damages. Error prone translesion synthesis past some of these DNA damages ... a DNA repair gene; APC, a cell cycle regulator; MLH1, a DNA-repair gene; and BRCA1, another DNA-repair gene. Indeed, cancer ...
It works by inhibiting the synthesis of RNA and DNA of carcinoma cells. It is a competitive inhibitor of cell-free RNA and DNA ... Anthramycin has been shown particularly effective against sarcomas, lymphomas, and gastrointestinal neoplasms.[citation needed ... forms a complex with DNA which blocks off synthesis by prohibiting DNA binding with proper enzymes. The species is heavily ...
The damage of DNA due to exposure of UV rays will lead to expression of p53, thereby leading to eventual arrest of the cell ... These enhance angiogenesis and aid in the growth of UV-induced neoplasms. It has been reported that UV radiation leads to local ... This allows DNA repair mediated by endogenous mechanisms like the nucleotide excision repair system. In addition, apoptosis ... UVB rays are a primary mutagen that can only penetrate through the epidermal (outermost) layer of the skin, resulting in DNA ...
Cancer alters the DNA of cells and the mutated genetic material is passed on to daughter cells, resulting in neoplasms. The ... Selection for specific phenotypes in dog breeding causes long-range linkage disequilibrium in their DNA. Certain areas of ... Carcinogenesis is linked with DNA mutations, chromosomal translocations, dysfunctional proteins, and aberrant cell cycle ... which leads to long ranges of repeated DNA sequences. These repeated sequences caused by decreased genetic diversity within ...
2009). "Towards identification of hereditary DNA mismatch repair deficiency: sebaceous neoplasm warrants routine ... Along with neoplasms of the sebaceous gland, this patient developed cerebral neoplasms, characteristic of Turcot syndrome. ... Routine immunohistochemical detection of DNA mismatch repair proteins help identify hereditary DNA mismatch repair deficiency. ... Colorectal cancer is the most common visceral neoplasm in Muir-Torre syndrome patients. It is named for EG Muir and D Torre. A ...
Neoplasms occurring in epithelial tissue such as the liver, gastrointestinal tract, and the pancreas have been linked to ... A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other ... These diol-epoxides covalently bind with DNA base pairs, most often with guanine and adenine to form stable adducts within the ... Since these toxicants do not directly act on DNA, little is known about the mechanistic pathway. It has been proposed that ...
Base J was the first hypermodified base that was known in eukaryotic DNA and had been found in Trypanosoma brucei DNA in the ... Mutations in this gene were first identified in myeloid neoplasms with deletion or uniparental disomy at 4q24. TET2 may also be ... December 2014). "DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid ... In general terms, DNA methylation causes specific sequences to become inaccessible for gene expression. The process of ...
... caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm ... If DNA repair is deficient, DNA damage tends to accumulate. Such excess DNA damage can increase mutational errors during DNA ... Excess DNA damage can also increase epigenetic alterations due to errors during DNA repair. Such mutations and epigenetic ... July 2007). "DNA damage, homology-directed repair, and DNA methylation". PLoS Genetics. 3 (7): e110. doi:10.1371/journal.pgen. ...
In response to DNA damage NDRG1 translocates from the cytoplasm to the nucleus, where it may inhibit cell growth and promote ... "A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms". ... These authors strongly suggest a link between the increase in the MGMT DNA repair pathway and a delay in the aging process in ... Dominick G, Bowman J, Li X, Miller RA, Garcia GG (2017). "mTOR regulates the expression of DNA damage response enzymes in long- ...
... one of the myeloproliferative neoplasms or certain other myeloid neoplasms. A disorder of platelet function is a ... The resulting platelets are unable to produce new cyclooxygenase because they have no DNA. Normal platelet function will not ...
It is a cytidine analogue that causes hypomethylation of DNA by inhibition of DNA methyltransferase. Decitabine is a similar ... Cazzola M, Malcovati L, Invernizzi R (2011). "Myelodysplastic/myeloproliferative neoplasms". Hematology Am Soc Hematol Educ ... "Myelodysplastic/myeloproliferative neoplasms". Am. J. Clin. Pathol. 132 (2): 281-9. doi:10.1309/AJCPJ71PTVIKGEVT. PMID 19605822 ... classification of the myeloid neoplasms". Blood. 100 (7): 2292-302. doi:10.1182/blood-2002-04-1199. PMID 12239137. Vardiman J, ...
The absence of staining for DNA mismatch repair MSH2, MSH6, and MLH1 may suggest a diagnosis of MTS and identify patients for ... The incidence of MTS in patients with sebaceous neoplasms as high as 14 to 50%. Besides mutations in mismatch repair genes, Wnt ... SGc accounts for approximately 0.7% of all skin cancers and 0.2 to 4.6% of all malignant cutaneous neoplasms. Notable risk ... MTS results from defects in DNA mismatch repair genes, MLH1, MSH2, and MSH6, leading to a buildup of unstable microsatellite ...
Some scientists have identified these mutations as deletions in the mitochondrial DNA of Hürthle cells found in neoplasms and ... Hürthle cell neoplasms are somewhat difficult to differentiate between being benign or malignant. Since the size and growth ... The mitochondrial DNA of Hürthle cell carcinoma contain somatic mutations. Hürthle cell carcinomas consists of at least 75% ... This high amount of mitochondria is reported to be a result of mutations in the mitochondrial DNA. ...
... expression of DNA repair enzymes due to epigenetic methylation of DNA repair genes or altered microRNAs that control DNA repair ... Malignancy, malignant neoplasm and malignant tumor are synonymous with cancer. *Malignant ascites ...
In 2017 archived tissue from this operation were subjected to DNA sequencing. This revealed a Arg74His (Arginine to Histidine: ... Epithelioid blue nevus List of cutaneous neoplasms associated with systemic syndromes Carney Syndrome at eMedicine Carney, J.; ... "Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association". J Clin Endocrinol Metab. 96 (11): ...
... would reflect the earliest event in formation of a malignant neoplasm. In experimental evaluation of specific DNA repair ... In addition to the oxidative DNA damage 8-OHdG, H. pylori infection causes other characteristic DNA damages including DNA ... With a DNA repair deficiency, DNA damage persists in cells at a higher than typical level (5th level from the top in figure); ... When expression of DNA repair genes is reduced, DNA damage accumulates in cells at a higher than normal rate, and this excess ...
... deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of ... Folates are essential for the synthesis of DNA, the modification of DNA and RNA, the synthesis of methionine from homocysteine ... This pathology results from persistently thwarted attempts at normal DNA replication, DNA repair, and cell division, and ... Folate is required for the body to make DNA and RNA and metabolise amino acids necessary for cell division. As humans cannot ...
... single stranded breaks in DNA, double stranded breaks in DNA, the intercalation of foreign substances into the DNA double helix ... In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... Cellular DNA integrity is often compromised in cancer. Genome instability can refer to the accumulation of extra copies of DNA/ ... or any abnormal changes in DNA tertiary structure that can cause either the loss of DNA, or the misexpression of genes. It ...
... substituting for thymine in DNA, and can induce DNA mutation in the same way as 2-aminopurine. It is used mainly as an ... experimental mutagen, but its deoxyriboside derivative (5-bromo-2-deoxy-uridine) is used to treat neoplasms. 5-BrU exists in ... so it can be incorporated into DNA by aligning opposite adenine residues during DNA replication (see below left). Alternatively ... This means that 5-BrU can be present in DNA either opposite adenine or guanine. The three forms frequently interchange so base- ...
DNA binding. • sequence-specific DNA binding. • transcription factor activity, sequence-specific DNA binding. • transcriptional ... aka Hurthle-Cell Neoplasms).[15] Tumors expressing the PAX8/PPARy are usually present in at a young age, small in size, present ... transcription regulatory region DNA binding. • RNA polymerase II core promoter sequence-specific DNA binding. • RNA polymerase ... transcription, DNA-templated. • otic vesicle development. • metanephric distal convoluted tubule development. • negative ...
DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... 2005). "Assessment of JC polyoma virus in colon neoplasms". Dis. Colon. Rectum. 48 (1): 86-91. doi:10.1007/s10350-004-0737-2. ... DNA virus. HBV Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. ... DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV Lymphocytic ...
radiology - randomized trial - rebound - receptor (immunology) - recombinant - recombinant DNA - recombinant DNA technology - ... neoplasm - nephrotoxic - neuralgia - neurological complications of AIDS - neuropathy - neutralization - neutralizing antibody ... DNA - Domain (biology) - dose-ranging study - dose-response relationship - double-blind study - drug resistance - drug-drug ... DNA) - Department of Health and Human Services (DHHS/HHS or DHHS) - desensitization - diabetes mellitus (DM) - diagnosis - ...
Neoplasms 60% increase in death rate 60% increased death rate from neoplasms. In 1999-2003, neoplasms accounted for 17% of all ... Cooper, A. (2001). "Human Origins and Ancient Human DNA". Science. 292 (5522): 1655-6. doi:10.1126/science.292.5522.1655. PMID ... and it has been suggested that the results may be due to posthumous modification and thermal degradation of the DNA.[34][35][36 ... The initial comparison of the mitochondrial DNA from the skeleton known as Lake Mungo 3 (LM3) with that of ancient and modern ...
A non-viral PDGF "bio patch" can regenerate missing or damaged bone by delivering DNA in a nano-sized particle directly into ... Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes. Ligand. Growth factors. ...
Cells have mechanisms for repairing single-strand DNA damage and double-stranded DNA damage. However, double-stranded DNA ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... Single-strand DNA damage is then passed on through cell division; damage to the cancer cells' DNA accumulates, causing them to ... Radiation therapy works by damaging the DNA of cancerous cells. This DNA damage is caused by one of two types of energy, photon ...
... deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of ... This pathology results from persistently thwarted attempts at normal DNA replication, DNA repair, and cell division, and ... DNA production[edit]. Folate derivatives participate in the biosynthesis of both purines and pyrimidines. Formyl folate is ... Folic acid is essential for the body to make DNA, RNA, and metabolise amino acids, which are required for cell division. Not ...
Inserting the DNA into the effector cell can be accomplished by several methods. Most commonly, this is done using a lentivirus ... "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): ... Chromosomal translocations involve moving a large region of DNA from one chromosome to another. This move can result in placing ... purified from each person are modified by a virus that inserts genes that encode a chimaeric antigen receptor into their DNA, ...
... and plays a regulatory role in S phase DNA replication and DNA damage repair.[17][18][19] Specifically, p21 has a high affinity ... Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes. Ligand. Growth factors. ... not exposed to DNA damaging agents, have shown that DNA damage occurring in mother cell S-phase can induce p21 accumulation ... p21 acts as an effective inhibitor of DNA S-phase DNA synthesis though permits NER, leading to the proposal that p21 acts to ...
DNA repair deficiency in NSCLC[edit]. Deficiencies in DNA repair underlie many forms of cancer.[21] If DNA repair is deficient ... Large cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms originating from transformed ... Epigenetic promoter methylation in DNA repair genes in NSCLC Gene Frequency of hyper- (or hypo-) methylation DNA repair pathway ... In general, DNA damage appears to be the primary underlying cause of cancer.[18] Though most DNA damages are repairable,[17] ...
When the DNA double-strand helix is unwound, during DNA replication or transcription, for example, the adjacent unopened DNA ... Secondary neoplasm[edit]. Development of secondary neoplasia after successful chemotherapy or radiotherapy treatment can occur ... they prevent mitosis because the DNA cannot duplicate itself. Also, after misincorporation of the molecules into DNA, DNA ... This ability to bind covalently to DNA via their alkyl group is the primary cause for their anti-cancer effects.[32] DNA is ...
DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72, D32-D33, 191-192/225) ... DNA virus. HBV Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. ... DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV Lymphocytic ...
... see malignant neoplasms). Thus, CpG island hyper/hypo-methylation in the promoters of DNA repair genes are likely central to ... DNA damage appears to be the primary underlying cause of cancer.[39][40] If accurate DNA repair is deficient, DNA damages tend ... DNA repair genes with hyper/hypo-methylated promoters in cancers[edit]. DNA repair genes are frequently repressed in cancers ... Excess DNA damage can also increase epigenetic alterations due to errors during DNA repair.[41][42] Such mutations and ...
Template:DNA and protein biosynthesis navs(edit talk links history)- Genetics ({{Protein biosynthesis navs}}, R) ... "Neoplasms and cancer" has been chosen to reflect the fact that not all tumours are benign. The word "cancer" has been included ...
DNA repair[edit]. In somatic cells, deficiencies in DNA repair sometimes arise by mutations in DNA repair genes, but much more ... 8560-8580) Complex epithelial neoplasms. Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that ... a b Bernstein C, Prasad AR, Nfonsam V, Bernstein H. (2013). DNA Damage, DNA Repair and Cancer, New Research Directions in DNA ... www.intechopen.com/books/new-research-directions-in-dna-repair/dna-damage-dna-repair-and-cancer ...
DNA damage and repair[edit]. DNA damage[edit]. DNA damage (or RNA damage in the case of some virus genomes) appears to be a ... Carcinogenesis and Neoplasm) and reference[24]). Furthermore, the ability of HRR to accurately and efficiently repair double- ... see DNA damage (naturally occurring). DNA damages are distinct from mutations although both are errors in the DNA. Whereas DNA ... DNA damage appears to play a key role in mammalian aging, and an adequate level of DNA repair promotes longevity (see DNA ...
"Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications". Genes Dev. 25 (5): 409-33. doi: ... superior information as compared to CT scans when seeking information about headache to confirm a diagnosis of neoplasm, ... The radiation used in CT scans can damage body cells, including DNA molecules, which can lead to cancer.[10] According to the ... such as DNA double strand breaks) on the cells' chemical bonds by X-ray radiation is proportional to that energy.[66] ...
... red wording indicates the central role of DNA damage and defects in DNA repair in progression to cancer.) When DNA repair is ... They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... "DNA Damage, DNA Repair and Cancer". In Chen C. New Research Directions in DNA Repair. InTech. doi:10.5772/53919. ISBN 978-953- ... Reduced expression of DNA repair genes disrupts DNA repair. This is shown in the figure at the 4th level from the top. (In the ...
Phosphoramide mustard forms DNA crosslinks both between and within DNA strands at guanine N-7 positions (known as interstrand ... Bernatsky S, Clarke AE, Suissa S (February 2008). "Hematologic malignant neoplasms after drug exposure in rheumatoid arthritis ... Myeloproliferative neoplasms, including acute leukemia, non-Hodgkin lymphoma and multiple myeloma, occurred in 5 of 119 ... It is believed to work by interfering with the duplication of DNA and the creation of RNA.[4] ...
positive regulation of transcription, DNA-templated. • cellular response to lithium ion. • cell adhesion. • extracellular ... Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes. Ligand. Growth factors. ...
... produces its anti-cancer effects by interfering with DNA replication and damaging the DNA in a cell. The DNA ... trophoblastic neoplasms, and ovarian carcinoma. Moreover, it also has been used as an immunosuppressive drug for various ... preventing DNA synthesis and RNA transcription from the affected DNA.. *DNA damage via the formation of cross-links which ... Attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace ...
Chan, Philip J.; Seraj, Ibrahim M.; Kalugdan, Theresa H.; King, Alan (১৯৯৬)। "Prevalence of Mycoplasma Conserved DNA in ...
Tüümuse DNA sisaldab adeniini, guaniini, tsütosiini, tümiini. Tüümuse ribonukleiinhapeRedigeeri. Tüümuse RNA sisaldab adeniini ... Tseng-Tong Kuo, Classification of thymic epithelial neoplasms: a controversial issue coming to an end?, J.Cell.Mol.Med. 5. ... C. Röpke, B. van Deurs, P. E. Høyer,DNA-synthesizing cells in human fetal thymus, Cell and Tissue Research, märts 1977, 178. ... J. N. BLAU, DNA SYNTHESIS IN THE ADULT AND AGEING GUINEA-PIG THYMUS, Clin. exp. Immunol. (1972) 11, 461-468. (vaadatud 5.02. ...
DNA methyltransferase inhibitors in development include decitabine, azacytidine, and hydralazine.[59]. The TRACERx project is ... Horn, L; Lovly, CM; Johnson, DH (2015). "Chapter 107: Neoplasms of the lung". In Kasper, DL; Hauser, SL; Jameson, JL; Fauci, AS ... Epigenetic changes-such as alteration of DNA methylation, histone tail modification, or microRNA regulation-may lead to ... Cancer develops following genetic damage to DNA and epigenetic changes. These changes affect the normal functions of the cell, ...
細胞的癌變與DNA及表觀遺傳等遺傳信息的突變有關,这些变化会影响细胞的正常功能,包括细胞增殖、程序性细胞死亡(细胞凋亡)和DNA修复。损伤累积的越多,癌症发生的风险就越高[23]。 ... Chapter 107: Neoplasms of the lung. (编) Kasper DL, Hauser SL, Jameson JL, Fauci AS, Longo DL, Loscalzo J. Harrison's Principles ... DNA methyltransferase),前者包括丙戊酸,伏立诺他(英语
As summarized in the articles Carcinogenesis and Neoplasm, for sporadic cancers in general, a deficiency in DNA repair is ... "DNA Damage, DNA Repair and Cancer". In Chen C. New Research Directions in DNA Repair. InTech. ISBN 978-953-51-1114-6 ... Other options include virtual colonoscopy and stool DNA screening testing (FIT-DNA). Virtual colonoscopy via a CT scan appears ... including altered DNA and blood hemoglobin. A positive result should be followed by colonoscopy. FIT-DNA has more false ...
Jagadish, N; R Rana; D Mishra; M Garg; R Selvi; A Suri (2006). "Characterization of immune response in mice to plasmid DNA ... hCG was discovered to be expressed in certain kinds of malignant neoplasms, including breast cancer, adenocarcinoma of the ...
DNA binding. • p53 binding. • DNA binding, bending. • RNA polymerase II transcription factor binding. • chromatin DNA binding. ... "GATA1 Expression in BCR/ABL1-negative Myeloproliferative Neoplasms". Annals of Laboratory Medicine. 38 (4): 296-305. doi: ... enhancer sequence-specific DNA binding. • RNA polymerase II regulatory region sequence-specific DNA binding. • transcriptional ... sequence-specific DNA binding. • RNA polymerase II core promoter sequence-specific DNA binding. • ...
Neoplasm" by people in Harvard Catalyst Profiles by year, and whether "DNA, Neoplasm" was a major or minor topic of these ... "DNA, Neoplasm" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "DNA, Neoplasm" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "DNA, Neoplasm". ...
Hypomethylation of DNA from benign and malignant human colon neoplasms Message Subject. (Your Name) has forwarded a page to you ... When compared to DNA from adjacent normal tissue, DNA from both benign colon polyps and malignant carcinomas was substantially ... The methylation state of DNA from human colon tissue displaying neoplastic growth was determined by means of restriction ... that hypomethylation is a consistent biochemical characteristic of human colonic tumors and is an alteration in the DNA that ...
Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms. Download Prime ... AnimalsCalreticulinCell LineDNA RepairDrug SynergismHeterograftsHumansJanus Kinase 2MiceMyeloproliferative DisordersNeoplasms ... Ruxolitinib-induced Defects in DNA Repair Cause Sensitivity to PARP Inhibitors in Myeloproliferative Neoplasms. Blood. 2017 12 ... Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms.. Blood. 2017 12 ...
... and show that array-based DNA methylation analysis holds promise as an ancillary tool to further characterize uterine neoplasms ... we describe distinct DNA methylation signatures in uterine neoplasms ... ConclusionHerein, we describe distinct DNA methylation signatures in uterine neoplasms and show that array-based DNA ... DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics. *. ...
... was to characterize patterns of local progression following resection for pancreatic intraductal papillary mucinous neoplasms ( ... it is not clear whether this progression represents recurrence of the same neoplasm or an independent second neoplasm.Methods: ... Targeted DNA Sequencing Reveals Patterns of Local Progression in the Pancreatic Remnant Following Resection of Intraductal ... Mutations in the tumors were compared in order to determine the relationship between neoplasms. In parallel, clinical and ...
Predicting the grade of dysplasia of pancreatic cystic neoplasms using cyst fluid DNA methylation markers. Tatsuo Hata, Marco ... Predicting the grade of dysplasia of pancreatic cystic neoplasms using cyst fluid DNA methylation markers ... Predicting the grade of dysplasia of pancreatic cystic neoplasms using cyst fluid DNA methylation markers ... Predicting the grade of dysplasia of pancreatic cystic neoplasms using cyst fluid DNA methylation markers ...
High-level DNA amplifications are common genetic aberrations in B-cell neoplasms ... High-level DNA amplifications are common genetic aberrations in B-cell neoplasms. American Journal of Pathology, 151(2):335-342 ... Using comparative genomic hybridization, a technique that has proven to be very sensitive for the detection of high-level DNA ... Using comparative genomic hybridization, a technique that has proven to be very sensitive for the detection of high-level DNA ...
Pedigree analysis showed multiple diverse neoplasms in first- and second-degree relatives. Constitutional DNA revealed a ... Constitutional DNA and DNA from unsorted leukaemic cells showed a BRCA2 c.4027A→G variant (supplementary figure 2). t-AML with ... Genomic DNA was isolated from cultured fibroblasts from index patients using the QIAamp DNA Mini Kit (Qiagen, Hilden, Germany). ... Lane 3, DNA from embryonal rhabdomyosarcoma. Lane 4, DNA from fibrosarcoma showing the mutated amplicon only, indicating a ...
Malignant neoplasms[edit]. DNA damage[edit]. The central role of DNA damage and epigenetic defects in DNA repair genes in ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... Deficiencies in DNA repair cause increased mutation rates.[34][35][36] A deficiency in DNA repair, itself, can allow DNA ... Bernstein C, Prasad AR, Nfonsam V, Bernstei H (2013). "DNA Damage, DNA Repair and Cancer". New Research Directions in DNA ...
562P - Detection of colorectal neoplasm using promoter methylation of stool DNA in stool samples in Korean patients. ... Detection of colorectal neoplasm using promoter methylation of stool DNA in stool samples in Korean patients ... The methylation status of SFRP2, TFPI2, NDRG4, BMP3 and Vimentin promoters in bisulfate modified stool DNA was investigated in ... Colorectal cancer screening using stool DNA has yielded greater detection rate than conventional fecal ocult blood testing. The ...
DNA manipulations, production of retroviruses. The CALR wild-type, del52, ins5, and Δex9 sequences were cloned into pMSCV ... Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors. J Cell Mol Med 2013;17(11): ... Rationale for targeting the PI3K/Akt/mTOR pathway in myeloproliferative neoplasms. Clin Lymphoma Myeloma Leuk 2013;13(Suppl 2): ... Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med 2013;369(25):2391-2405. ...
title = "DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohns Colitis: Implications for ... DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohns Colitis: Implications for ... DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohns Colitis: Implications for ... DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohns Colitis : Implications for ...
... can be applied for the management of malignant and benign neoplasms. Detecting circulating DNA in cancer patients may help ... develop a DNA profile for early stage diagnosis in malignancies. The technical issues of obtaining, using, and analyzing CCFDNA ... Qualitative and quantitative testing of circulating cell free DNA (CCFDNA) ... 6. Clearance of DNA from Circulation. The circulating DNA in plasma is protein-bound (nucleosomal) DNA and circulating DNA has ...
DNA & RNA*BLAST (Basic Local Alignment Search Tool). *BLAST (Stand-alone). *E-Utilities ... Genetic changes in neoplasms arising in congenital melanocytic nevi: differences between nodular proliferations and melanomas. ... numerical chromosomal aberrations in atypical nodular proliferations arising in CMN identifies these as clonal neoplasms with a ...
In five cases we could confirm the presence of the same mutation in granulocyte DNA as well as T lymphocyte DNA, whereas seven ... Serial dilutions starting at 80 ng/μL and ending at 0.4 ng/μL of both a wild type (WT) and a fully mutated DNA sample were used ... Individuals with DNA available for molecular analysis have assigned sample numbers (e.g. MPD221). The rs10974944 (a tagging SNP ... Myeloproliferative Neoplasms. *. Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein ...
Pair-end DNA sequencing. DNA samples from tumors and their relative controls were processed in parallel. Genomic DNA of each ... Adapter ligation and DNA cluster preparation are performed by Illumina Nextera DNA Sample Preparation KIT (Illumina), and tumor ... 2000 Repair of oxidative DNA damage in Drosophila melanogaster: identification and characterization of dOgg1, a second DNA ... DNA oxidation during the processing of the DNA samples) of the C , A mutations that we have observed. C , A (G , T) ...
... high-grade intraepithelial neoplasms, and cancers, were collected retrospectively. The groups included ANs with (AN+SP) or ... are at higher risk for synchronous colorectal advanced neoplasms (AN) and cancers. However, it remains unclear whether there is ... The majority of high-grade intraepithelial neoplasms in both groups showed a contiguous component of conventional adenoma. ... DNA methylation Is the Subject Area "DNA methylation" applicable to this article? Yes. No. ...
To address the clinical relevance of small DNA variants in chronic myeloid neoplasms (CMNs), an Association for Molecular ... Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms: A Report of the Association for Molecular Pathology Rebecca ... Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms: A Report of the Association for Molecular Pathology Rebecca ... To address the clinical relevance of small DNA variants in chronic myeloid neoplasms (CMNs), an Association for Molecular ...
Genetic: DNA banking. Observational. *University Hospital, Lille. *Institut Pasteur de Lille. *University of Lille Nord de ... neoplasms [CONDITION] AND child [AGE-GROUP] , Recruiting, Not yet recruiting, Available Studies (1984 records) ... neoplasms [CONDITION] AND child [AGE-GROUP] , Recruiting, Not yet recruiting, Available Studies ... 1984 Studies found for: neoplasms [CONDITION] AND child [AGE-GROUP] , Recruiting, Not yet recruiting, Available Studies ...
Seroprevalence and genital DNA prevalence of HPV types 6, 11, 16 and 18 in a cohort of young Norwegian women: study design and ... Cervical Intraepithelial Neoplasm (CIN) in Women (Gardasil) (V501-015) (FUTURE II). The safety and scientific validity of this ... DNA Virus Infections. Virus Diseases. Sexually Transmitted Diseases, Viral. Sexually Transmitted Diseases. Skin Diseases, Viral ...
Our results indicate that high concentration of extracellular DNA in blood plasma along with dec … ... Circulating nucleic acids in blood of patients with stomach and colon neoplasms] Biomed Khim. May-Jun 2005;51(3):321-8. ... Our results indicate that high concentration of extracellular DNA in blood plasma along with decreased level of extracellular ...
Here, we assessed the application of microbial DNA markers, as compared with and in combination with fecal immunochemical test ... Fecal microbial DNA markers serve for screening colorectal neoplasm in asymptomatic subjects. Meer van Journal of ... Fecal microbial DNA markers serve for screening colorectal neoplasm in asymptomatic subjects ... Quantitation of fecal microbial DNA markers may serve as a new test, stand alone, or in combination with FIT for screening ...
ol,,li,,p,Targeted RNA sequencing detected a cryptic ,i,G3BP1-PDGFRB,/i, rearrangement in a myeloid neoplasm with eosinophilia ... DNA Helicases * RNA Helicases Grant support * T32 CA009216/CA/NCI NIH HHS/United States ... A cryptic imatinib-sensitive G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia Blood Adv. 2020 Feb 11;4(3):445 ... Targeted RNA sequencing detected a cryptic G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia and normal FISH ...
Stomach Neoplasms/genetics*. Substance. *DNA, Neoplasm. LinkOut - more resources. Full Text Sources. *Sercrisma International S ...
Cancer; Mesothelial-cells; Recombinant-DNA; Genes; Lung-cancer; Lung-cells; Neoplasms; Pleural-cavity; Tumors; Diagnostic- ... techniques; Malignant-neoplasms; Microscopic-analysis; Diagnostic-tests; Pathogenesis; Genetic-factors; Molecular-biology; Lung ...
Retention: Samples With DNA. Description:. tumor tissue whole blood. Sampling Method Non-Probability Sample ... Lung NeoplasmsA Phase 2, Randomized, Open-Label Study Of Single Agent CI-1033 In Patients With Advanced Non-Small Cell Lung ... Lung NeoplasmsA Phase 2, Open-Label, Multicenter Study of the GARFT Inhibitor in Patients With Metastatic Non-Small Cell Lung ... Lung NeoplasmsA Clinical Efficacy Study Of An Oral Tyrosine Kinase Inhibitor Of VEGFR-2 Given In Combination With Chemotherapy ...
Colorectal Neoplasm. Intestinal Neoplasms. Gastrointestinal Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Neoplasms ... Neoplasms. Digestive System Diseases. Intestinal Neoplasms. Gastrointestinal Neoplasms. Digestive System Neoplasms. Neoplasms ... Sample Collection Study to Evaluate DNA Markers in Subjects With Inflammatory Bowel Disease (IBD). The safety and scientific ... Inflammatory Bowel Disease Colorectal Neoplasms Digestive System Diseases Colonic Diseases Colorectal Cancer Device: Stool ...
Ewing sarcoma is an intense neoplasm predominantly occurring in adolescents and. Posted on February 19, 2018. by Dale Miles ... DNA Damage Signalling and Repair Inhibitors 2019 Base WP designed by Iografica Themes. ... Ewing sarcoma is an intense neoplasm predominantly occurring in adolescents and has a poor prognosis when metastasized. without ...
Recently, it has been demonstrated that it is possible to detect molecular alterations analysing cell-free DNA (cfDNA) in plas ... Genetic studies in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) are essential to establish the ... Circulating cell-free DNA improves the molecular characterisation of Ph-negative myeloproliferative neoplasms Nieves Garcia- ... Circulating cell-free DNA improves the molecular characterisation of Ph-negative myeloproliferative neoplasms Nieves Garcia- ...
Genital Neoplasms, Male. Urogenital Neoplasms. Neoplasms by Site. Neoplasms. Genital Diseases, Male. Niraparib. Poly(ADP-ribose ... A Phase 2 Efficacy and Safety Study of Niraparib in Men With Metastatic Castration-Resistant Prostate Cancer and DNA-Repair ... An Efficacy and Safety Study of Niraparib in Men With Metastatic Castration-Resistant Prostate Cancer and DNA-Repair Anomalies ... Biomarker-positive by at least one of the following criteria: (a) Biallelic deoxyribonucleic acid (DNA)-repair anomaly based on ...
  • Myeloproliferative neoplasms (MPNs) often carry JAK2(V617F), MPL(W515L), or CALR(del52) mutations. (unboundmedicine.com)
  • Therapy related myeloid neoplasms (t-MNs) constitute a distinct clinical syndrome including therapy related acute myeloid leukaemia (t-AML), myelodysplastic syndrome (t-MDS), and myelodysplastic/myeloproliferative neoplasm (t-MDS/MPN). (bmj.com)
  • Calreticulin mutants responsible for myeloproliferative neoplasms specifically activate the thrombopoietin receptor and in turn JAK2. (bloodjournal.org)
  • Mutations in the calreticulin gene (CALR) represented by deletions and insertions in exon 9 inducing a −1/+2 frameshift are associated with a significant fraction of myeloproliferative neoplasms (MPNs). (bloodjournal.org)
  • Background Myeloproliferative neoplasms constitute a group of diverse chronic myeloid malignancies that share pathogenic features such as acquired mutations in the JAK2 , TET2 , CBL and MPL genes. (haematologica.org)
  • There are recent reports that a JAK2 gene haplotype (GGCC or 46/1) confers susceptibility to JAK2 mutation-positive myeloproliferative neoplasms. (haematologica.org)
  • The aim of this study was to examine the role of the JAK2 GGCC haplotype and germline mutations of TET2 , CBL and MPL in familial myeloproliferative neoplasms. (haematologica.org)
  • Design and Methods We investigated patients with familial (n=88) or sporadic (n=684) myeloproliferative neoplasms, and a control population (n=203) from the same demographic area in Italy. (haematologica.org)
  • Sequence analysis of TET2 , CBL and MPL was conducted in the 88 patients with familial myeloproliferative neoplasms. (haematologica.org)
  • Results Association analysis revealed no difference in haplotype frequency between familial and sporadic cases of myeloproliferative neoplasms ( P =0.6529). (haematologica.org)
  • As we observed variability in somatic mutations in the affected members of a pedigree with myeloproliferative neoplasms, we postulated that somatic mutagenesis is increased in familial myeloproliferative neoplasms. (haematologica.org)
  • Although the overall incidence of malignant disorders did not differ significantly between cases of familial and sporadic myeloproliferative neoplasms, malignancies were more frequent in patients with familial disease aged between 50 to 70 years ( P =0.0198) than in patients in the same age range with sporadic myeloproliferative neoplasms. (haematologica.org)
  • Conclusions We conclude that the JAK2 GGCC haplotype and germline mutations of TET2 , CBL or MPL do not explain familial clustering of myeloproliferative neoplasms. (haematologica.org)
  • As we observed an increased frequency of malignant disorders in patients with familial myeloproliferative neoplasms, we hypothesize that the germline genetic lesions that underlie familial clustering of myeloproliferative neoplasms predispose to somatic mutagenesis that is not restricted to myeloid hematopoietic cells but cause an increase in overall carcinogenesis. (haematologica.org)
  • Myeloproliferative neoplasms (MPN) constitute a group of phenotypically diverse chronic myeloid malignancies that are characterized by the presence of clonal hematopoiesis and an excessive production of terminally differentiated myeloid blood cells. (haematologica.org)
  • Genetic studies in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) are essential to establish the correct diagnosis and to optimise their management. (cdc.gov)
  • 6 NCCN Guidelines for Patients ® : Myeloproliferative Neoplasms, 2018 How to use this book Who should read this book? (nccn.org)
  • This book is about treatment for adults with myeloproliferative neoplasms. (nccn.org)
  • Chronic myeloproliferative neoplasms are a group of diseases in which the bone marrow makes too many red cells, white cells or platelets. (aamds.org)
  • In myeloproliferative neoplasms (MPN), the bone marrow makes too many of one or more types of blood cells. (aamds.org)
  • In chronic myeloproliferative neoplasms, the bone marrow makes too many cells. (aamds.org)
  • Certain types of myeloproliferative neoplasms and myelodysplastic syndromes may become acute leukemia, another type of blood cancer. (aamds.org)
  • Although myeloproliferative neoplasms cannot be cured, there are treatments for all patients with this condition. (aamds.org)
  • Furthermore, ROS have a major role in carcinogenesis and disease progression in the myeloproliferative neoplasms (MPNs), where the malignant clone itself produces excess of ROS thereby creating a vicious self-perpetuating circle in which ROS activate proinflammatory pathways (NF- κ B) which in turn create more ROS. (hindawi.com)
  • The Philadelphia negative chronic myeloproliferative neoplasms (MPNs) encompass essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF). (hindawi.com)
  • Though it has been remarkable to have witnessed the major advances in the understanding of the molecular pathogenesis of the chronic myeloproliferative neoplasms (MPN) over the past three decades, many challenges remain. (haematologica.org)
  • In this second part of our two-part review, we discuss the use of mutation profiling in the diagnosis, prognosis, and treatment of patients with myeloproliferative neoplasms and other myeloid diseases. (cancernetwork.com)
  • 1] As an example, for patients with a suspected myeloproliferative neoplasm (MPN), the presence of mutated CALR and/or absence of mutated JAK2 virtually excludes polycythemia vera as a potential diagnosis, with only rare exceptions. (cancernetwork.com)
  • 63 NCCN Guidelines for Patients ® : Myeloproliferative Neoplasms, 2018 Dictionary Dictionary acute myeloid leukemia (AML) A fast-growing cancer that starts in the bone marrow and causes too many immature white blood cells to be made. (nccn.org)
  • Experimental Design: Pancreatic cyst fluid samples from 183 patients (29 discovery, 154 validation) aspirated after surgical resection were analyzed for methylated DNA at selected genes (SOX17, BNIP3, FOXE1, PTCHD2, SLIT2, EYA4 and SFRP1) using methylation-specific droplet-digital PCR (dd-QMSP). (aacrjournals.org)
  • The identification of highly amplified DNA regions and genes included in the amplicons provides important information for further analyses of genetic events involved in lymphomagenesis. (uzh.ch)
  • CONCLUSIONS: The current results indicated that quantitative PCR-based testing for DNA methylation of 4 genes holds great promise for cervical cancer screening and warrants further population-based studies using standardized DNA methylation testing. (elsevier.com)
  • In comparison with normal cells, human cancer cells exhibit global DNA hypomethylation, which can lead to genomic instability, and specific promoter hypermethylation of tumor-suppressor genes, which mediates gene silencing ( 3 ). (frontiersin.org)
  • O objetivo do presente estudo foi quantificar a metilação global do DNA em leucócitos sanguíneos de cães portadores de LNH, comparando com a metilação global do DNA de leucócitos sanguíneos de cães sadios e identificar genes diferentemente metilados nas mesmas amostras. (usp.br)
  • Apesar de termos usado amostras caninas em um ensaio desenvolvido especificamente para o DNA humano (Infinium Methylation EPIC BeadChip) foi possível a identificação de genes diferentemente metilados e possíveis novos alvos com potencial preventivo ou terapêutico. (usp.br)
  • The aim of the current study is to quantify the global DNA methylation of blood from dogs bearing non-Hodgkin's lymphoma, comparing them with the methylation content and pattern of healthy dogs and identify differently methylated genes in the same samples. (usp.br)
  • ROS are involved in inflammation-induced oxidative damage to cellular components including regulatory proteins and DNA. (hindawi.com)
  • These results indicate that hypomethylation is a consistent biochemical characteristic of human colonic tumors and is an alteration in the DNA that precedes malignancy. (sciencemag.org)
  • Mutations in the tumors were compared in order to determine the relationship between neoplasms. (ovid.com)
  • To determine if these genetic lesions appear in Drosophila tumors we have sequenced the genomes of 17 malignant neoplasms caused by mutations in l(3)mbt , brat , aurA , or lgl . (g3journal.org)
  • Many of these tumors are hyperplasias that present during larval development and eventually differentiate, but others behave as frankly malignant neoplasms that are refractory to differentiation signals, lethal to the host and immortal. (g3journal.org)
  • The question remains, however, as to the extent of GI in other samples of Ph tumors and, indeed, in different types of Drosophila malignant neoplasms. (g3journal.org)
  • However, little is known about fecal recovery efficiency of DNA exfoliated from UGI tumors. (elsevier.com)
  • Conclusions: While recovery efficiencies are low, ingested cellular DNA simulating daily amounts shed from UGI tumors can readily be detected in stool. (elsevier.com)
  • This ingestion model has potential value in studying the effects of perturbations relevant to the fecal recovery of DNA exfoliated from UGI tumors. (elsevier.com)
  • Gastrointestinal stromal tumors (GISTs) are relatively rare neoplasms of the gastrointestinal tract originating from the pluripotential mesenchymal stem cells, which differentiate into interstitial Cajal cells. (dovepress.com)
  • Aberrant patterns of DNA methylation appear to play a key role in the development of hematopoietic tumors in humans, constitute a special mechanism of transcriptional control and may be influenced by genetic and environmental variations. (usp.br)
  • Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
  • Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
  • Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
  • Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
  • DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR. (labome.org)
  • Molecular studies of lymphoblastic B-cell lymphoma, the most prevalent neoplasm (50% of all tumors), showed that the lymphomas were clonal, overexpressed Myc His , and exhibited the P2 to P1 promoter shift in Myc expression, a hallmark of MYC/Myc deregulation in human endemic Burkitt lymphoma and mouse plasmacytoma. (aacrjournals.org)
  • DNMT2 or TRDMT1, the smallest mammalian DNMT is believed to participate in the recognition of DNA damage, DNA recombination, and mutation repair. (frontiersin.org)
  • The term neoplasm refers to an abnormal growth of tissue caused by the rapid division of cells that have undergone some form of mutation. (news-medical.net)
  • Furthermore, we demonstrate that the transcriptional age acceleration computed from our within-tissue predictor is significantly correlated with mutation burden, mortality risk and cancer stage in several types of cancer from the TCGA database, and offers complementary information to DNA methylation age. (cdc.gov)
  • 5 , 6 t-MNs are regarded as complex diseases and previously published data on genetic predisposition to t-MNs pointed to an interactive effect of different single nucleotide polymorphisms (SNPs) in pathways that mediate carcinogen detoxification, proliferation, DNA repair, and apoptosis. (bmj.com)
  • 7 , 8 The demonstration of increased familial tumour risk in patients with AML following a primary neoplasm further supported the concept of genetic susceptibility to t-MNs. (bmj.com)
  • Genetic changes in neoplasms arising in congenital melanocytic nevi: differences between nodular proliferations and melanomas. (nih.gov)
  • Application of Cell-free DNA Analysis to Cancer Treatment. (harvard.edu)
  • However, six pedigrees were suggestive for a hereditary breast and ovarian cancer syndrome, three of a Li-Fraumeni like syndrome, and three index patients showed multiple primary neoplasms. (bmj.com)
  • A neoplasm can be benign , potentially malignant, or malignant ( cancer ). (wikipedia.org)
  • Malignant neoplasms are commonly called cancer. (wikipedia.org)
  • Secondary neoplasm refers to any of a class of cancerous tumor that is either a metastatic offshoot of a primary tumor, or an apparently unrelated tumor that increases in frequency following certain cancer treatments such as chemotherapy or radiotherapy . (wikipedia.org)
  • Detecting circulating DNA in cancer patients may help develop a DNA profile for early stage diagnosis in malignancies. (mdpi.com)
  • In addition, use of DNA assays for clinical medicine can be significantly sensitive and specific if cancer-specific DNA alterations are tested instead of elevation of circulating DNA concentration [ 1 - 8 ]. (mdpi.com)
  • Detecting somatic mutations from plasma DNA in advanced cancer patients may be potentially preferable when repeated tumor biopsies are not feasible and genomic analysis of archival tumor is deemed insufficient [ 9 ]. (mdpi.com)
  • Our results indicate that high concentration of extracellular DNA in blood plasma along with decreased level of extracellular RNA on the surface of blood cells correlate with development of gastrointestinal cancer. (nih.gov)
  • The purpose of this study is to assess the efficacy, safety, and pharmacokinetics of niraparib in men with metastatic castration resistant prostate cancer (mCRPC) and deoxyribonucleic acid (DNA) repair anomalies. (clinicaltrials.gov)
  • ORR in participants with measurable metastatic castration-resistant prostate cancer (mCRPC) and DNA-repair anomalies. (clinicaltrials.gov)
  • BACKGROUND: DNA methylation may be used a potential biomarker for detecting cervical cancer. (elsevier.com)
  • These data raise the possibility that a cell line altered previously for cytokine secretion may be readily modified to provide immunologic specificity for the neoplasms of individual cancer patients. (elsevier.com)
  • Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. (curehunter.com)
  • These clustering analyses have the power to demonstrate, for instance, cross-cancer consistency in the functional importance of the DNA binding domain of tumor suppressor p53, whether in a cancer with extensive exome data (ovarian serous adenocarcinoma) or in a cancer with much less extensive exome data (e.g. rectal adenocarcinoma). (yale.edu)
  • Is hurtle cell neoplasm defined as cancer? (healthtap.com)
  • Hurtel cell neoplasm can be adenoma (not cancer ) or carcinoma (cancer). (healthtap.com)
  • We are investigating use of DNA-based and functional approaches for predicting response to targeted therapies, in breast cancer, lung cancer, pancreatic cancer, and melanoma. (yale.edu)
  • The central features of DNA damage, epigenetic alterations and deficient DNA repair in progression to cancer are shown in red. (thenakedscientists.com)
  • Tobacco smoke causes increased exogenous DNA damage, and these DNA damages are the likely cause of lung cancer due to smoking. (thenakedscientists.com)
  • Helicobacter pylori infection produces high levels of reactive oxygen species that damage DNA and contributes to gastric cancer. (thenakedscientists.com)
  • Bile acids, at high levels in the colons of humans eating a high fat diet, also cause DNA damage and contribute to colon cancer. (thenakedscientists.com)
  • Inflammation-induced ROS that cause DNA damage can trigger apoptosis, but may also cause cancer if repair and apoptotic processes are insufficiently protective. (thenakedscientists.com)
  • I would add that the argument that non-ionizing radiation cannot cause cancer because it cannot break DNA double bonds, has been disproven by the acceptance that the lower energy ultra-violet light can, with time, cause skin cancer. (thenakedscientists.com)
  • Thus, homologous MYC/Myc -Eμ rearrangements lead to B-cell and plasma-cell neoplasms in humans and mice. (aacrjournals.org)
  • Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. (harvard.edu)
  • Neoplasm is an abnormal growth of tissue which, if it forms a mass, is commonly referred to as a tumor . (wikipedia.org)
  • Current English, however, both medical and non-medical, uses tumor as a synonym for a neoplasm (a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears enlarged in size. (wikipedia.org)
  • USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size. (bvsalud.org)
  • A proteína USP44 apresentou ampla expressão na maioria das amostras avaliadas e não foi observada associação entre a expressão protéica e o estado de ploidia do DNA ou extensão do tumor . (bvsalud.org)
  • Interleukin-2-secreting mouse fibroblasts transfected with genomic DNA from murine neoplasms induce tumor-specific immune responses that prolong the lives of tumor-bearing mice. (elsevier.com)
  • As a novel means of augmenting the immunogenicity of the gene products, unfractionated, sheared genomic DNA from various tumor cell lines (B16F1 melanoma, B16F10 melanoma, MOPC-315 plasmacytoma, C1498 lymphoma, or J558 myeloma), or from non-neoplastic liver cells of tumor-free mice, was transfected into LM cells, a mouse fibroblast cell-line (H-2k) that had been modified previously by retroviral gene transfer to secrete interleukin-2 (IL-2). (elsevier.com)
  • The antitumor responses were specific for the type of tumor from which the DNA was obtained. (elsevier.com)
  • Fingerprint Dive into the research topics of 'Interleukin-2-secreting mouse fibroblasts transfected with genomic DNA from murine neoplasms induce tumor-specific immune responses that prolong the lives of tumor-bearing mice. (elsevier.com)
  • The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the table below. (medscape.com)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive malignancy derived from precursors of plasmacytoid dendritic cells. (bloodjournal.org)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic disease, often presenting in the skin. (bloodjournal.org)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective therapy. (haematologica.org)
  • Background Therapy related myeloid neoplasms (t-MNs) are complex diseases originating from an interplay between exogenous toxicities and a susceptible organism. (bmj.com)
  • DNA methylation at the 5-position of cytosine, catalyzed by DNA methyltransferases (DNMTs), is the predominant epigenetic modification in mammals. (frontiersin.org)
  • DNA methylation and histone modifications are two key players in epigenetic regulation of gene expression in mammalian cells. (frontiersin.org)
  • DNA methylation, a covalent chemical modification resulting in addition of a methyl group at the carbon 5 position of the cytosine ring in CpG dinucleotides, is one of the most consistent and best known epigenetic events in human cancers. (frontiersin.org)
  • This chapter focuses on the diagnosis and classification of atypical melanocytic neoplasms and melanoma in pediatric patients. (springer.com)
  • UV light from solar radiation causes DNA damage that is important in melanoma. (thenakedscientists.com)
  • METHODS: This hospital-based, retrospective, case-control study was conducted in 185 patients and included patients who had a normal uterine cervix (n = 53), cervical intraepithelial neoplasm type 1 (CIN1) (n = 37), CIN2 (n = 22), CIN3 (n = 24), carcinoma in situ (CIS) (n = 22), squamous cell carcinoma (SCC, n = 20), and adenocarcinoma (AC) (n = 7). (elsevier.com)
  • Cooper GS, Markowitz SD, Chen Z, Tuck M, Willis JE, Berger BM, Brenner DE, Li L. Evaluation of Patients with an Apparent False Positive Stool DNA Test: The Role of Repeat Stool DNA Testing. (harvard.edu)
  • Ruxolitinib inhibited 2 major DSB repair mechanisms, BRCA-mediated homologous recombination and DNA-dependent protein kinase-mediated nonhomologous end-joining, and, when combined with olaparib, caused abundant accumulation of toxic DSBs resulting in enhanced elimination of MPN primary cells, including the disease-initiating cells from the majority of patients. (unboundmedicine.com)
  • Using NGS, we identify distinct mechanisms for development of metachronous or synchronous neoplasms in patients with IPMN. (ovid.com)
  • Patients with a primary IPMN with HGD or with positive family history are at an increased risk to develop subsequent high-risk neoplasms in the remnant pancreas. (ovid.com)
  • In addition, mutational analyses were performed using constitutional DNA from index patients, and deleterious heterozygous germline mutations were assessed for loss of heterozygosity in sorted leukaemic cells by single nucleotide polymorphism array. (bmj.com)
  • Methods: At a single center in 2 blinded phases, we assayed methylated bone morphogenic protein 3, methylated N-Myc downstream-regulated gene 4, and mutant KRAS in DNA extracted from paraffin-embedded benign lesions, and matched control tissues of patients with IBD, who were followed for subsequent colorectal dysplasia. (elsevier.com)
  • Conclusions: Selected DNA markers known to be present in advanced IBD neoplasia can also be detected in both tissues and stools from IBD patients with small adenomas and serrated lesions. (elsevier.com)
  • Here, we assessed the application of microbial DNA markers, as compared with and in combination with fecal immunochemical test (FIT), in detecting CRC and adenoma in symptomatic patients and asymptomatic subjects. (oncologieportal.nl)
  • We have assessed the molecular profile of a cohort of 107 MPN patients [33 polycythaemia vera (PV), 56 essential thrombocythaemia (ET), 14 primary myelofibrosis (PMF) and 4 unclassifiable MPN] by next-generation sequencing (NGS) using cfDNA and paired granulocyte DNA. (cdc.gov)
  • Sentinel node biopsy in atypical melanocytic neoplasms in childhood: a single institution experience in 24 patients. (springer.com)
  • Quantitation of fecal microbial DNA markers may serve as a new test, stand alone, or in combination with FIT for screening colorectal neoplasm in asymptomatic subjects. (oncologieportal.nl)
  • ConclusionHerein, we describe distinct DNA methylation signatures in uterine neoplasms and show that array-based DNA methylation analysis holds promise as an ancillary tool to further characterize uterine neoplasms, especially in cases which are diagnostically challenging by conventional techniques. (medworm.com)
  • Benign neoplasms are non-cancerous forms of tissue proliferation such as skin moles, lipomas or uterine fibroids. (news-medical.net)
  • benign neoplasms , in situ neoplasms , malignant neoplasms , and neoplasms of uncertain or unknown behavior. (wikipedia.org)
  • Qualitative and quantitative testing of circulating cell free DNA (CCFDNA) can be applied for the management of malignant and benign neoplasms. (mdpi.com)
  • Targeted sequencing of cfDNA showed a comparable mutational profile (100% accuracy) to the one obtained in granulocytic DNA and a strong correlation was observed between the variant allele frequency (VAF) of gene mutations in both DNA sources. (cdc.gov)
  • Thermo Fisher Scientific's Ion Torrent Oncomine Myeloid Research Assay interrogates DNA mutations, RNA fusion transcripts and gene expression levels associated with myeloid cancers in a single run, yielding results in 2-3 days. (medindia.net)
  • The neoplasms are positive for platelet-derived growth factor α (PDGFα) mutations. (dovepress.com)
  • Potentially-malignant neoplasms include carcinoma in situ . (wikipedia.org)
  • [5] Malignant neoplasms are also simply known as cancers and are the focus of oncology . (wikipedia.org)
  • DNA damage is considered to be the primary underlying cause of malignant neoplasms known as cancers. (thenakedscientists.com)
  • In human samples, the expression of TFF1 was specifically observed in pancreatic intraepithelial neoplasm (PanIN), but was frequently lost in the invasive component of pancreatic ductal adenocarcinoma (PDAC). (jci.org)
  • For lymphoid neoplasms, e.g. lymphoma and leukemia , clonality is proven by the amplification of a single rearrangement of their immunoglobulin gene (for B cell lesions) or T cell receptor gene (for T cell lesions). (wikipedia.org)
  • For this, the DNA obtained from the buffy coat of peripheral venous blood samples from 10 healthy dogs and 9 dogs with multicentric non-Hodgkin's lymphoma were used. (usp.br)
  • Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridization. (thefreelibrary.com)
  • These data demonstrate that gene amplifications in B-cell neoplasms are much more frequent than previously assumed. (uzh.ch)
  • Paradoxically, genome-wide DNA hypomethylation may also play a causal role in carcinogenesis by inducing chromosomal instability and spurious gene expression. (frontiersin.org)
  • Myc overexpression stimulates gene amplification, [12] presumably through DNA over-replication. (wikipedia.org)
  • Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
  • In this investigation, we show that T-oligo may mediate its DNA damage responses through the p53/p73 pathway, thereby inhibiting cellular proliferation and inducing apoptosis or senescence. (osti.gov)
  • A substance that inhibits or prevents the proliferation of neoplasms. (ebi.ac.uk)
  • The clinicopathologic features of this interesting neoplasm have recently been reviewed, but subsequent reports have invigorated the debate regarding the tumor's histogenesis. (thefreelibrary.com)
  • Using comparative genomic hybridization, a technique that has proven to be very sensitive for the detection of high-level DNA amplifications, we analyzed 108 cases of B-cell neoplasms (42 chronic B-cell leukemias, 5 mantle cell lymphomas, and 61 aggressive B-cell lymphomas). (uzh.ch)
  • Ahlquist, David A. / Fecal Recovery of Ingested Cellular DNA : Implications for Noninvasive Detection of Upper Gastrointestinal Neoplasms . (elsevier.com)
  • Currently, detection and identification of soluble analytes in biological fluids is conducted by methods including bioassays, ELISA, PCR, DNA chip or strip tests. (osti.gov)
  • Detection and quantification of 5-methyl 2'-deoxycytidine in genomic DNA has been performed using micellar high-performance capillary electrophoresis (HPCE) with UV-Vis detection. (nih.gov)
  • The detection and quantification of nucleosides through enzymatic hydrolyses notably increases the specificity of the technique and allows its exploitation in the analysis of poorly purified and/or concentrated DNA samples such as those obtained from meristematic plant regions and paraffin-embedded tissues. (nih.gov)
  • Such inflammation causes oxidative DNA damage. (thenakedscientists.com)
  • Only polyubiquitylation on defined lysines, mostly on K48 and K29, is related to degradation by the proteasome (referred to as the "molecular kiss of death"), while other polyubiquitylations (e.g. on K63, K11, K6 and M1) and monoubiquitylations may regulate processes such as endocytic trafficking, inflammation, translation and DNA repair. (wikipedia.org)
  • Although a number of studies have characterized the DNA binding properties of the WT1 protein, recent evidence has suggested that WT1 may also have a role in RNA metabolism. (mendeley.com)
  • Background: Stool DNA testing represents a potential noninvasive approach to detect upper gastrointestinal (UGI) neoplasms. (elsevier.com)
  • It was observed that MG132 concentrations of greater than 0.25 µM caused a significant apoptosis as evidenced by DNA damage, cleavage of caspases 3, 7, 9, 10, Bid and PARP, and mitochondrial release of Smac/DIABLO and Cytochrome c. (cdc.gov)
  • Agarose gel electrophoresis showed a typical internucleosomal DNA cleavage pattern (DNA ladder), a reliable indicator of apoptosis. (biomedsearch.com)
  • Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis . (selleckchem.com)
  • A452 induces apoptosis and DNA damage of CRC cells. (selleckchem.com)
  • We show here that cell lines expressing JAK2(V617F), MPL(W515L), or CALR(del52) accumulated reactive oxygen species-induced DNA double-strand breaks (DSBs) and were modestly sensitive to poly-ADP-ribose polymerase (PARP) inhibitors olaparib and BMN673. (unboundmedicine.com)
  • It is tempting to define neoplasms as clonal cellular proliferations but the demonstration of clonality is not always possible. (wikipedia.org)
  • The finding of frequent numerical chromosomal aberrations in atypical nodular proliferations arising in CMN identifies these as clonal neoplasms with a genomic instability consistent with a mitotic spindle checkpoint defect. (nih.gov)
  • The aim of this study was to characterize patterns of local progression following resection for pancreatic intraductal papillary mucinous neoplasms (IPMN) using targeted next-generation sequencing (NGS). (ovid.com)

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