Metolazone: A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.Diuretics: Agents that promote the excretion of urine through their effects on kidney function.Sodium Chloride Symporters: A subclass of symporters found in KIDNEY TUBULES, DISTAL that are the major pathway for salt resorption. Inhibition of these symporters by BENZOTHIADIAZINES is the basis of action of some DIURETICS.Halogens: A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.KetonesSodium Chloride Symporter Inhibitors: Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.Chlorothiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)Indapamide: A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.Dizziness: An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.Alcoholic Beverages: Drinkable liquids containing ETHANOL.Protective Devices: Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.Urine Specimen Collection: Methods or procedures used to obtain samples of URINE.Diagnostic Techniques and Procedures: Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.Postural Orthostatic Tachycardia Syndrome: A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.Thoracic Outlet Syndrome: A neurovascular syndrome associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the superior thoracic outlet. This may result from a variety of anomalies such as a CERVICAL RIB, anomalous fascial bands, and abnormalities of the origin or insertion of the anterior or medial scalene muscles. Clinical features may include pain in the shoulder and neck region which radiates into the arm, PARESIS or PARALYSIS of brachial plexus innervated muscles, PARESTHESIA, loss of sensation, reduction of arterial pulses in the affected extremity, ISCHEMIA, and EDEMA. (Adams et al., Principles of Neurology, 6th ed, pp214-5).Cubital Tunnel Syndrome: Compression of the ULNAR NERVE in the cubital tunnel, which is formed by the two heads of the flexor carpi ulnaris muscle, humeral-ulnar aponeurosis, and medial ligaments of the elbow. This condition may follow trauma or occur in association with processes which produce nerve enlargement or narrowing of the canal. Manifestations include elbow pain and PARESTHESIA radiating distally, weakness of ulnar innervated intrinsic hand muscles, and loss of sensation over the hypothenar region, fifth finger, and ulnar aspect of the ring finger. (Joynt, Clinical Neurology, 1995, Ch51, p43)Ribs: A set of twelve curved bones which connect to the vertebral column posteriorly, and terminate anteriorly as costal cartilage. Together, they form a protective cage around the internal thoracic organs.Hyperventilation: A pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.Cervical Rib Syndrome: A condition associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the thoracic outlet and caused by a complete or incomplete anomalous CERVICAL RIB or fascial band connecting the tip of a cervical rib with the first thoracic rib. Clinical manifestations may include pain in the neck and shoulder which radiates into the upper extremity, PARESIS or PARALYSIS of brachial plexus innervated muscles; sensory loss; PARESTHESIAS; ISCHEMIA; and EDEMA. (Adams et al., Principles of Neurology, 6th ed, p214)Ulnar Nerve: A major nerve of the upper extremity. In humans, the fibers of the ulnar nerve originate in the lower cervical and upper thoracic spinal cord (usually C7 to T1), travel via the medial cord of the brachial plexus, and supply sensory and motor innervation to parts of the hand and forearm.Decompression, Surgical: A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)Saudi ArabiaBenzothiadiazines: Heterocyclic compounds of a ring with SULFUR and two NITROGEN atoms fused to a BENZENE ring. Members inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.Bendroflumethiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Blood Pressure Determination: Techniques for measuring blood pressure.Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Blood Pressure Monitoring, Ambulatory: Method in which repeated blood pressure readings are made while the patient undergoes normal daily activities. It allows quantitative analysis of the high blood pressure load over time, can help distinguish between types of HYPERTENSION, and can assess the effectiveness of antihypertensive therapy.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Heart: The hollow, muscular organ that maintains the circulation of the blood.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.Benzazepines: Compounds with BENZENE fused to AZEPINES.Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.Angiotensin-Converting Enzyme Inhibitors: A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Nasal Decongestants: Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)Medical Assistance: Financing of medical care provided to public assistance recipients.Colestipol: Highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels.Nonprescription Drugs: Medicines that can be sold legally without a DRUG PRESCRIPTION.Uncompensated Care: Medical services for which no payment is received. Uncompensated care includes charity care and bad debts.Beneficence: The state or quality of being kind, charitable, or beneficial. (from American Heritage Dictionary of the English Language, 4th ed). The ethical principle of BENEFICENCE requires producing net benefit over harm. (Bioethics Thesaurus)Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Therapeutic Equivalency: The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.Health Care Costs: The actual costs of providing services related to the delivery of health care, including the costs of procedures, therapies, and medications. It is differentiated from HEALTH EXPENDITURES, which refers to the amount of money paid for the services, and from fees, which refers to the amount charged, regardless of cost.Drug Costs: The amount that a health care institution or organization pays for its drugs. It is one component of the final price that is charged to the consumer (FEES, PHARMACEUTICAL or PRESCRIPTION FEES).
Not to be confused with Metolazone, a diuretic.. Metaxalone (marketed by King Pharmaceuticals under the brand name Skelaxin) is ...
... (INN) is a diuretic, part of the class of low-ceiling sulfonamide diuretics. Fenquizone is used primarily in the ... Quinethazone Metolazone fenquizone - drug information from MIMS (Thailand). ...
These loop diuretics may be combined with thiazide diuretics such as oral metolazone or intravenous chlorothiazide for a ... In the absence of symptomatic low blood pressure intravenous nitroglycerin is often used in addition to diuretic therapy to ... Some heart failure patients on chronic diuretics can undergo excessive diuresis. In the case of diastolic dysfunction without ... However, people on long-standing diuretic regimens can become tolerant, and dosages must be progressively increased. If high ...
... such as chlorthalidone and metolazone. These agents are more properly termed thiazide-like diuretics. Thiazide diuretics also ... thiazide-like diuretics) are often considered as thiazide diuretics, although they are not thiazides from a chemical ... Thiazide (/ˈθaɪəzaɪd/) is a type of molecule and a class of diuretics often used to treat hypertension (high blood pressure) ... Zhu Z, Zhu S, Liu D, Cao T, Wang L, Tepel M (2005). "Thiazide-like diuretics attenuate agonist-induced vasoconstriction by ...
... metolazone, and indapamide, among others), loop diuretics (including furosemide, bumetanide, and torsemide), acetazolamide, ... The sulfonylureas and thiazide diuretics are newer drug groups based on the antibacterial sulfonamides. Allergies to ... The moiety is also present in other medications that are not antimicrobials, including thiazide diuretics (including ... Acetazolamide Bumetanide Chlorthalidone Clopamide Furosemide Hydrochlorothiazide Indapamide Mefruside Metolazone Xipamide ...
... indapamide chlorthalidone metolazone Potassium-sparing diuretics: amiloride triamterene spironolactone eplerenone In the United ... Diuretics help the kidneys eliminate excess salt and water from the body's tissues and blood. Loop diuretics: bumetanide ... The thiazide diuretics also deplete circulating potassium unless combined with a potassium-sparing diuretic or supplemental ... Thiazide diuretics are effective, recommended as the best first-line drug for hypertension by many experts, ...
... may be combined with other diuretics (typically loop diuretics) to treat diuretic resistance in CHF, chronic renal ... Metolazone is frequently prescribed in addition to the loop diuretic. Metolazone may be used for edema caused by liver ... metolazone or another diuretic may be used alone, or combined with other diuretics for moderate or severe heart failure. In ... Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is ...
Examples include metolazone. Some, such as indapamide are considered thiazide-like diuretics, but do not necessarily have the ... A thiazide-like diuretic is a sulfonamide diuretic that has similar physiological properties to a thiazide diuretic, but does ...
Low ceiling diuretics. The term "low ceiling diuretic" is used to indicate a diuretic has a rapidly flattening dose ... Loop diuretics have this ability, and are therefore often synonymous with high ceiling diuretics. Loop diuretics, such as ... The antihypertensive actions of some diuretics (thiazides and loop diuretics in particular) are independent of their diuretic ... High ceiling/loop diuretic. High ceiling diuretics may cause a substantial diuresis - up to 20% of the filtered load ...
... Diuretics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of ... C03BA02 Quinethazone C03BA03 Clopamide C03BA04 Chlortalidone C03BA05 Mefruside C03BA07 Clofenamide C03BA08 Metolazone C03BA09 ... C03EA06 Chlortalidone and potassium-sparing agents C03EA07 Cyclopenthiazide and potassium-sparing agents C03EA12 Metolazone and ...
Antihypertensives: diuretics (C03). Sulfonamides. (and etacrynic acid). CA inhibitors (at PT). *Acetazolamide ...
View list of generic drugs that are classified under Diuretics along with ICD Code. Find related prescribing information and ... Metolazone This medication is a quinazoline diuretic, prescribed for high blood pressure. ... loop diuretics - ICD Code -Y54.4 Furosemide This medication is a diuretic agent, prescribed for fluid retention in people with ... Thiazide Diuretic - ICD Code -Y54.5 Chlorothiazide. This medication is a thiazide diuretic, prescribed for high blood pressure ...
Metolazone. Antihypertensive Agents. Diuretics. Natriuretic Agents. Physiological Effects of Drugs. Sodium Chloride Symporter ... Fasting Study of Metolazone Tablets 10 mg and Zaroloxyn® Tablets 10 mg. The safety and scientific validity of this study is the ... Drug: Metolazone Tablets 10 mg Drug: Zaroloxyn® Tablets 10 mg Phase 1 ... The objective of this study was to investigate the bioequivalence of Mylan metolazone 10 mg tablets to Celltech Zaroxolyn® 10 ...
Some pills combine more than one type of diuretic or combine a diuretic with another blood pressure medication. ... Diuretics, sometimes called water pills, help rid your body of salt (sodium) and water. Most work by making your kidneys ... Metolazone. Examples of loop diuretics include:. *Bumetanide (Bumex). *Ethacrynic acid (Edecrin). *Furosemide (Lasix) ... Diuretics, sometimes called water pills, treat a variety of conditions, such as high blood pressure, glaucoma and edema. Find ...
Detailed drug Information for metolazone. Includes common brand names, drug descriptions, warnings, side effects and dosing ... Metolazone is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, ... Proper Use of metolazone. In addition to the use of metolazone, treatment for your high blood pressure may include weight ... Metolazone is available only with your doctors prescription .. Before Using metolazone. In deciding to use a medicine, the ...
Metolazone Tablets) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related ... Metolazone is a quinazoline diuretic, with properties generally similar to the thiazide diuretics. The actions of metolazone ... Metolazone Tablets, USP for oral administration contain 2.5 mg, 5 mg or 10 mg of metolazone, USP, a diuretic/saluretic/ ... Diuretics. Furosemide and probably other loop diuretics given concomitantly with metolazone can cause unusually large or ...
Not to be confused with Metolazone, a diuretic.. Metaxalone (marketed by King Pharmaceuticals under the brand name Skelaxin) is ...
Oval and has been identified as Metolazone 2.5 mg. It is supplied by Teva Pharmaceuticals USA. ... Metolazone is used in the treatment of edema; high blood pressure and belongs to the drug class thiazide diuretics. There is no ... Metolazone. Imprint:. 7215 9 3 Strength:. 2.5 mg. Color:. Pink. Shape:. Elliptical / Oval. Availability:. Prescription only. ... Thiazide diuretics. Pregnancy Category:. B - No proven risk in humans. CSA Schedule:. Not a controlled drug. Labeler / Supplier ...
Indications for thiazide diuretics (5). 1. chlorothiazide. 2. hydrochlorothiazide. 3. chlorthalidone. 4. metolazone. 5. ... IV loop diuretics are used for (left/right HF). Oral Loop diuretics are used for (left/right HF) ... Adverse affect of thiazide diuretics (6). 1. chlorothiazide. 2. hydrochlorothiazide. 3. chlorthalidone. 4. metolazone. 5. ... Pharm #6 - Diuretics Flashcards Preview PHARM/MHD - Exam #4 , Pharm #6 - Diuretics , Flashcards ...
metolazone. Zaroxolyn. How It Works. Diuretics cause the kidneys to remove more sodium and water from the body, which helps to ... Potassium-sparing diuretics might be used, along with other diuretics, if you have low potassium levels. footnote 1 ... Potassium-sparing diuretics, unlike most other diuretics, do not cause potassium levels to drop. Rather, they may lead to high ... Quinazoline diuretics are similar to the thiazide diuretics, but are used only in certain people such as those with kidney ...
Examples include metolazone. Some, such as indapamide are considered thiazide-like diuretics, but do not necessarily have the ... A thiazide-like diuretic is a sulfonamide diuretic that has similar physiological properties to a thiazide diuretic, but does ...
Diuretics to ↓ preload. • E.g. Furosemide and Metolazone. ↑ Cardiac Contractility • Vassopressors to ↑BP. • Dopamine, ...
The most popular diuretic medications include chlorothiazide, or Diuril; hydrochlorothiazide; metolazone, or Zaroxolyn; ... Diuretics. Diuretics, also known as water pills, are medications that trigger the kidneys to excrete sodium and water. This ... These medications are generally prescribed with a diuretic in order to be more effective. The most popular medications in this ... According to MayoClinic.com, thiazide diuretic medications are often the initial therapy prescribed for individuals with high ...
... , Thiazide, Hydrochlorothiazide, Chlorothiazide, Chlorthalidone, Indapamide, Metolazone, Zaroxolyn. ... Thiazide Diuretic. search Thiazide Diuretic, Thiazide, Hydrochlorothiazide, Chlorothiazide, Chlorthalidone, Indapamide, ... Thiazide Diuretics are minimally effective when GFR falls below 30 ml/min ... Do not use Thiazide Diuretics in patients with a history of Hyponatremia ...
Metolazone is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, ... Information about this metolazone-oral-route. Pregnancy Category. Explanation. All Trimesters. B. Animal studies have revealed ... Metolazone is used to treat fluid retention (edema) and swelling that is caused by congestive heart failure, kidney disease, or ... Metolazone is also used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure ...
thiazide diuretics. *Lasix (furosemide) vs. Zaroxolyn (metolazone). *lisinopril (Zestril, Prinivil, Qbrelis) ACE Inhibitor ...
Serum levels of which substances are increased as a result of the effects of thiazide diuretics?. ...
Metolazone (Mykrox, Zaroxolyn). *Polythiazide (Renese). *Quinethazone (Hydromox). *Trichlormethiazide (Diurese, Metahydrin, ... Diuretics and zinc. S Afr Med J. 1982;62:373-375. 11. Shintani S, Murase H, Tsukagoshi H, et al. Glycyrrhizin (licorice)- ... Reportedly, thiazide diuretics can cause loss of zinc in the urine.10 Since zinc deficiency is relatively common, you should ... Thiazide diuretics cause a constant and significant loss of potassium. The classic treatment for this is to eat bananas and ...
Diuretics (acetazolamide, metolazone). *Ethambutol and isoniazid for tuberculosis. *Statins (atorvastatin) to lower blood ...
Metolazone: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Metolazone is in a class of medications called diuretics (water pills). It causes the kidneys to reduce the amount of water ... Metolazone comes as a tablet to take by mouth. It is usually taken once a day. Take metolazone at around the same time every ... Metolazone controls high blood pressure but does not cure it. Continue to take metolazone even if you feel well. Do not stop ...
Medications Included in Thiazide Diuretics:. *Indapamide (Lozol). *Chlorthiazide (Diuril). *Metolazone (Zaroxolyn). * ... For some, a diuretic is enough to lower blood pressure, but for others it is not. In these cases, a combination of diuretic and ... Diuretic Medications. Diuretics are used to help the kidneys remove salt, or sodium, and excess water. By doing this, the ... A doctor will decide what type of medication to combine with the diuretic. This decision is often made based on whether or not ...
Metolazone. 0.2 mg/kg/dose PO. Used with loop diuretic, may increase to bid ...
... shorter-acting formulation of metolazone in patients with mild to moderate hypertension. After base ... 0/Diuretics; 17560-51-9/Metolazone; 7440-09-7/Potassium From MEDLINE®/PubMed®, a database of the U.S. National Library of ... or 2.0 mg of the new formulation of metolazone or 2.5 mg of the older, long-acting metolazone in the other. Mean blood pressure ... Diuretics / administration & dosage*. Double-Blind Method. Female. Humans. Hypertension / blood, drug therapy*. Male. ...
thiazide diuretics (water pills; e.g., hydrochlorothiazide, indapamide, metolazone). *tolterodine. *tiotropium. *tramadol ...
Metolazone may be combined with other diuretics (typically loop diuretics) to treat diuretic resistance in CHF, chronic renal ... Metolazone is frequently prescribed in addition to the loop diuretic. Metolazone may be used for edema caused by liver ... metolazone or another diuretic may be used alone, or combined with other diuretics for moderate or severe heart failure. In ... Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is ...
ix) Diuretics: for example, furosemide, ethacrynic acid, chlorothiazide, chlorthalidone, metolazone, and indapamide. ...
FurosemideHydrochlorothiazideChlorthalidoneSpironolactoneCongestive heart fHypertensionExcretionUric acidWater pillSodiumPeople try thiazide diureticsHypokalemiaReabsorptionPotassium levelsDoseAntihypertensiveInhibitorsSide effects of metolazoneMedicationTypes of diureticsInteract with metolazoneFormulation of metolazoneQuinazolineMechanismTabletsTake metolazoneOsmotic diureticsCalciumWeak diureticUrinate more oftenPatientsDosageSulfonamide diureticHigh blood prExamplesBeta-blockersDiastolic blood pr
- Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities. (wikipedia.org)
- Loop diuretics, such as furosemide (starting at 1-2 mg/kg/d), may improve edema. (medscape.com)
- Metolazone may be beneficial in combination with furosemide for resistant edema. (medscape.com)
- Furosemide is a potent diuretic which increases dramatically urine output in most patients. (healthtap.com)
- See: http://en.wikipedia.org/wiki/ Furosemide regarding discovery of use of furosemide for race horses. (healthtap.com)
- Lasix ( furosemide ) is a powerful diuretic meant to remove excess fluid and sodium from the body. (healthtap.com)
- However, GFR is rarely normal in heart failure patients, hence the maximal effective diuretic dose is higher, with recommended absolute maximal iv boluses (given over 30 minutes) as: 160-200 mg of furosemide, 4 8 mg of bumetanide, 100-200 mg of torsemide 8 . (bcs.com)
- The cornerstone of diuretic therapy in reducing congestive symptoms are sulphonamide-based loop diuretics i.e. furosemide, bumetanide and torsemide. (bcs.com)
- Hydrochlorothiazide, chlorthalidone, metolazone. (brainscape.com)
- Metolazone is around ten times as potent as hydrochlorothiazide. (wikipedia.org)
- Hydrochlorothiazide belongs to a class of drugs called thiazide diuretics. (healthline.com)
- Although it is not a true thiazide, metolazone is chemically related to the thiazide class of diuretics (for example, chlorthalidone [Hygroton], hydrochlorothiazide ), and works in a similar manner. (medicinenet.com)
- Tell your doctor if you are taking a diuretic (water pill), such as chlorothiazide, hydrochlorothiazide (HCTZ), or metolazone. (umm.edu)
- This combination medication contains diuretics, prescribed for hypertension and congestive heart failure. (medindia.net)
- This combination medication contains diuretics, prescribed for congestive heart failure and fluid retention. (medindia.net)
- This medication is a diuretic agent, prescribed for fluid retention in people with congestive heart failure, liver disease or kidney disorder. (medindia.net)
- One of the primary uses of metolazone is for treating edema (fluid retention) associated with congestive heart failure (CHF). (wikipedia.org)
- Loop diuretics are used to treat edema in congestive heart failure as well as kidney and liver disease. (verywellhealth.com)
- Metolazone is used to treat fluid retention (edema) in people with congestive heart failure, or a kidney disorder such as nephrotic syndrome. (cigna.com)
- Metolazone is a diuretic that primarily used to treat congestive heart failure and high blood pressure. (selleckchem.com)
- This combination medication contains potassium-sparing diuretic and thiazide diuretic, prescribed for essential hypertension and fluid retention caused by various conditions, including heart disease. (medindia.net)
- This medication is a diuretic, prescribed for fluid retention and hypertension. (medindia.net)
- Metolazone is also used alone or together with other medicines to treat high blood pressure (hypertension). (drugs.com)
- Metolazone tablets are also indicated for the treatment of hypertension , alone or in combination with other antihypertensive drugs of a different class. (rxlist.com)
- Mykrox tablets, a more rapidly available form of metolazone, are intended for the treatment of new patients with mild to moderate hypertension. (rxlist.com)
- Thiazide diuretics are commonly used to treat hypertension . (epnet.com)
- Clinical studies of a new, low-dose formulation of metolazone for the treatment of hypertension. (biomedsearch.com)
- Two multicenter, double-blind, randomized studies were performed to determine the antihypertensive efficacy and effects on laboratory values of a new, shorter-acting formulation of metolazone in patients with mild to moderate hypertension. (biomedsearch.com)
- Diuretics are commonly known as 'water pills' and they treat several conditions, including hypertension (high blood pressure), heart failure , and kidney problems. (verywellhealth.com)
- To protect your health, you should be aware of several things about taking diuretics to control your hypertension. (verywellhealth.com)
- Metolazone is also used to treat high blood pressure (hypertension). (cigna.com)
- If diuretics are not able to lower your blood pressure, then your doctor may recommend additional hypertension medications to lower your blood pressure. (healthy-ojas.com)
- The British Hypertension Society recommends thiazide-type diuretic or calcium channel blocker as the first-line therapy in patients over 55 years. (healthy-ojas.com)
- Various studies suggest low dose thiazide-type diuretic as the first-line therapy for hypertension patients. (healthy-ojas.com)
- Because of the effectiveness of thiazide diuretics as an antihypertensive, they are the first-line of treatment for most patients with hypertension. (healthy-ojas.com)
- However, in another review of the placebo-controlled hypertension trials with diuretics, there was only about 1% increase in new-onset diabetes compared with placebo. (healthy-ojas.com)
- If you have never had gout and using diuretics for hypertension treatment, you are at risk of developing gout. (healthy-ojas.com)
- The thiazides and thiazide-like diuretics reduce the risk of death, stroke, heart attack, and heart failure due to hypertension. (wikipedia.org)
- However, the recent 2011 UK National Institute for Health and Clinical Excellence (NICE) guideline on the management of primary hypertension in adults (CG127) recommend calcium channel blockers (CCBs) as first line agents in hypertension and advise that thiazide-like diuretics should only be used first line if CCBs are not suitable or if the patient has oedema or has a high risk of developing heart failure. (wikipedia.org)
- Diuretics are most commonly used to treat hypertension and heart failure by lowering the blood pressure and removing excess fluid. (baptist-health.com)
- This medication is an osmotic diuretic, prescribed for increased intracranial pressure, eye pressure, to maintain urine flow in kidney failure patients, and promotion of urinary excretion of toxic materials. (medindia.net)
- Steroids (for example, hydrocortisone) and nonsteroidal anti-inflammatory agents ( NSAIDs ) such as ibuprofen ( Motrin ), naproxen ( Naprosyn ), and nabumetone (Relafen) can reduce the effectiveness of metolazone by interfering with the excretion of salt and water. (medicinenet.com)
- Diuretics enhance the SELECTIVE excretion of various electrolytes and water by affecting renal mechanisms for ______ secretion and reabsorption. (cueflash.com)
- Potassium-losing diuretics (increase, decrease) lithium excretion and may cause toxicity. (cueflash.com)
- A role for the DCT and TZR in magnesium homeostasis was suggested by earlier studies that demonstrated an increase in urinary excretion of Mg after acute administration of a thiazide diuretic ( 4 , 5 , 6 ). (asnjournals.org)
- This review could not provide a valid estimate of short-term harms from all thiazide diuretics because there was incomplete reporting of metabolic effects (serum potassium, uric acid, creatinine, glucose, total cholesterol, low-density cholesterol and triglycerides) and the number of participants who dropped out of the trials due to adverse drug effects. (cochrane.org)
- Thiazide diuretics , which are chemically related to metolazone, are known to increase the amount of uric acid in the blood. (medicinenet.com)
- Metolazone is a thiazide diuretic (water pill). (drugs.com)
- This medication is a "water pill" (diuretic) that decreases the amount of water in the body by increasing urination. (patientassistance.com)
- Metolazone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. (cigna.com)
- Metolazone is a diuretic ('water pill') used in the treatment of high blood pressure and fluid accumulation. (medicinenet.com)
- Diuretics, sometimes called water pills, help rid your body of salt (sodium) and water. (mayoclinic.org)
- The primary target of all thiazide diuretics, including metolazone, is the distal convoluted tubule, part of the nephron in the kidney, where they inhibit the sodium-chloride symporter. (wikipedia.org)
- Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. (wikipedia.org)
- Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule, thiazide diuretics have limited effects on water balance and on electrolyte levels. (wikipedia.org)
- In addition to preventing fluid buildup, the use of metolazone may allow the patient to relax the amount of sodium restriction that is required. (wikipedia.org)
- Diuretics also called water or fluid pills, because it helps the body remove excess sodium and water, which help control blood pressure. (healthy-ojas.com)
- Renal reabsorption of sodium occurs in the distal convoluted tubule (DCT) in part via a Na-Cl symporter ( 1 ), which is the pharmacologic receptor for thiazide-type diuretic drugs (TZR) ( 2 ). (asnjournals.org)
- Possible side effects of diuretics include low sodium in your blood (hyponatremia), dizziness, headaches, increased thirst, and muscle cramps. (baptist-health.com)
- Diuretics can also affect blood potassium levels. (mayoclinic.org)
- Potassium-sparing diuretics , unlike most other diuretics, do not cause potassium levels to drop. (cigna.com)
- Potassium-sparing diuretics might be used, along with other diuretics, if you have low potassium levels. (cigna.com)
- This can occur when a diuretic leads to low potassium levels. (verywellhealth.com)
- Therapy with metolazone tablets should be titrated to gain an initial therapeutic response and to determine the minimal dose possible to maintain the desired therapeutic response. (rxlist.com)
- Your doctor will probably start you on a low dose of metolazone and gradually increase your dose, depending on your response to this medication. (medlineplus.gov)
- However, since greatly increased calcium levels in the body can cause side effects such as calcium deposits, if you are using thiazide diuretics you should consult with your physician on the proper dose of calcium and vitamin D for you. (medicalcityhospital.com)
- If your diuretic is on a twice-a-day schedule, the last dose should be taken no later than 3 p.m. (hoag.org)
- We included 60 randomized , double- blind trials that evaluated the dose-related trough blood pressure-lowering efficacy of six different thiazide diuretics in 11,282 participants treated for a mean duration of eight weeks. (cochrane.org)
- Encouraging patient self-monitoring with weight diary and modulation of diuretic dose is empowering for the patients themselves but may not be achievable in all, where supervision from specialist in-hospital and community support may be required. (bcs.com)
- Prolonged high-dose thiazide diuretic therapy can cause glucose intolerance and may occasionally lead to diabetes mellitus. (healthy-ojas.com)
- This medication is a quinazoline diuretic, prescribed for high blood pressure. (medindia.net)
- This medication is a diuretic, prescribed for bloating, puffiness and other signs of water weight gain related to menstrual symptoms with acetaminophen. (medindia.net)
- Some pills combine more than one type of diuretic or combine a diuretic with another blood pressure medication. (mayoclinic.org)
- Many diuretic drugs contain sulfa, so tell your doctor if you have an allergy to sulfa (or any medication). (verywellhealth.com)
- Metolazone may also be used for purposes not listed in this medication guide. (cigna.com)
- After baseline placebo-control periods, 105 patients were randomly assigned to receive single daily doses of either placebo or 0.5, 1.0, or 2.0 mg of the new formulation of metolazone for six weeks in one study, and 164 patients were randomized to receive 0.5, 1.0, or 2.0 mg of the new formulation of metolazone or 2.5 mg of the older, long-acting metolazone in the other. (biomedsearch.com)
- Quinazoline diuretics are similar to the thiazide diuretics, but are used only in certain people such as those with kidney problems and when other diuretics have not worked. (cigna.com)
- Metolazone is a quinazoline, a derivative of the similar diuretic quinethazone, as well as a sulfonamide. (wikipedia.org)
- Take metolazone at around the same time every day. (medlineplus.gov)
- Take metolazone exactly as directed. (medlineplus.gov)
- Continue to take metolazone even if you feel well. (medlineplus.gov)
- Your doctor will probably tell you not to take metolazone. (medlineplus.gov)
- How should I take metolazone? (cigna.com)
- Blood pressures of 51% to 58% of patients in the 0.5-mg metolazone group were controlled (diastolic blood pressure less than 90 or a fall of greater than or equal to 10 mmHg from baseline). (biomedsearch.com)
- In some cases, doctors recommend a daily potassium supplement for their patients on diuretics. (verywellhealth.com)
- Further, refractory oedema, diuretic resistance and cardio-renal syndrome may develop and pose additional challenges in the long-term management of these patients. (bcs.com)
- Consider transjugular portosystemic shunt (TIPS) placement in patients with Child's A/B cirrhosis with a low MELD score, if frequent paracentesis required despite dietary and diuretic compliance. (neurologyadvisor.com)
- Recent evidence suggests that β -adrenergic blocking agents may have a greater role in patients on dialysis and that thiazide diuretics may have a greater role in patients with advanced CKD. (asnjournals.org)
- Since magnesium deficiency is common anyway, if you take thiazide diuretics it would certainly make sense to take magnesium supplements at the US Dietary Reference Intake dosage. (epnet.com)
- What is the dosage for metolazone? (medicinenet.com)
- reduce diuretic dosage or hold if pre-renal failure develops. (neurologyadvisor.com)