A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS.
The circulation in a portion of the body of one individual of blood supplied from another individual.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.
Contractile activity of the MYOCARDIUM.
Hard or soft soluble containers used for the oral administration of medicine.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Inorganic salts of phosphoric acid.
Unforeseen occurrences, especially injuries in the course of work-related activities.
Databases devoted to knowledge about specific chemicals.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.
Decreased salivary flow.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A group of compounds that are derivatives of oxo-pyrrolidines. A member of this group is 2-oxo pyrrolidine, which is an intermediate in the manufacture of polyvinylpyrrolidone. (From Merck Index, 11th ed)
The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Therapy with two or more separate preparations given for a combined effect.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Selection of a type of occupation or profession.
The Balanced Budget Act (BBA) of 1997 establishes a Medicare+Choice program under part C of Title XVIII, Section 4001, of the Social Security Act. Under this program, an eligible individual may elect to receive Medicare benefits through enrollment in a Medicare+Choice plan. Beneficiaries may choose to use private pay options, establish medical savings accounts, use managed care plans, or join provider-sponsored plans.
Facilities having programs intended to promote and maintain a state of physical well-being for optimal performance and health.
Organizations which assume the financial responsibility for the risks of policyholders.
Federal program, created by Public Law 89-97, Title XVIII-Health Insurance for the Aged, a 1965 amendment to the Social Security Act, that provides health insurance benefits to persons over the age of 65 and others eligible for Social Security benefits. It consists of two separate but coordinated programs: hospital insurance (MEDICARE PART A) and supplementary medical insurance (MEDICARE PART B). (Hospital Administration Terminology, AHA, 2d ed and A Discursive Dictionary of Health Care, US House of Representatives, 1976)
The different methods of scheduling patient visits, appointment systems, individual or group appointments, waiting times, waiting lists for hospitals, walk-in clinics, etc.
A stand-alone drug plan offered by insurers and other private companies to beneficiaries that receive their Medicare Part A and/or B benefits through the Original Medicare Plan. It includes Medicare Private Fee-for-Service Plans that do not offer prescription drug coverage and Medicare Cost Plans offering Medicare prescription drug coverage. The plan was enacted as the Medicare Prescription Drug, Improvement and Modernization Act of 2003 with coverage beginning January 1, 2006.

Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current. (1/169)

BACKGROUND: The electrical alternans shown on an ST segment, ST alternans, is known as one of the most important predictors of ventricular fibrillation (VF). It has also been reported that sodium channel inhibition changes action potential configuration, especially on the repolarization phase. Thus, the sodium channel blocker may produce ST alternans and trigger reentrant arrhythmia. METHODS AND RESULTS: A sodium channel blocker (disopyramide, lidocaine, or flecainide) was infused selectively into the left anterior descending coronary artery in anesthetized, open-chest dogs. Sixty unipolar electrograms were simultaneously recorded from the entire cardiac surface of the heart. The amplitude of ST alternans (STa) was determined as the difference in the ST-segment magnitude between 2 consecutive electrograms. We accepted the greatest STa among 60 leads for evaluation. High-dose flecainide (100 microg. kg-1. min-1) increased STa and evoked a spontaneous VF. The STa in high-dose flecainide loading (8.7+/-3.4 mV; mean+/-SEM) was significantly greater than that in disopyramide or lidocaine (0. 9+/-0.4 and 0.8+/-0.2 mV, P<0.05). Treatment of 4-aminopyridine (4-AP) suppressed the increase in STa and the occurrence of VF evoked by flecainide, while E4031 or verapamil did not inhibit those. CONCLUSIONS: Flecainide caused the ST alternans that was closely correlated to the occurrence of VF. Because the ST alternans was suppressed by 4-AP treatment, a 4-AP-sensitive current such as Ito or Isus may play an important role on this phenomenon.  (+info)

Disopyramide improves hypoxia in patients with tetralogy of Fallot through a negative inotropic action. (2/169)

The hemodynamic and right ventricular volumetric effects of disopyramide were investigated in patients with tetralogy of Fallot (TF). Intracardiac pressure and oxygen saturation were measured, before and after intravenous administration of disopyramide (2 mg/kg) in 7 patients who had not had previous surgery. Right ventricular volume and the diameter of its outflow tract were analyzed in these 7 and in a further 4 patients with a previous shunt. Aortic oxygen saturation increased from 90.4+/-7.5 (mean+/-SD) to 94.1+/-5.5% (p<0.05) with an increase in pulmonary blood flow and pressure. The systolic pressure gradient between the main pulmonary artery and the right ventricle decreased from 59+/-8 to 42+/-9 mmHg (p<0.01). Aortic pressure fell from 77+/-5 to 67+/-4 mmHg (p<0.05). Systemic vascular resistance increased from 15.3+/-2.2 to 19.4+/-3.3 u x m2 (p<0.05). Pulmonary vascular resistance remained unchanged. The diastolic and systolic diameter indices of the right ventricular outflow tract increased from 17.8+/-3.8 to 20.5+/-3.4 and from 6.5+/-3.0 to 10.4+/-2.2 mm/m2, respectively (p<0.01), whereas the right ventricular ejection fraction decreased. Disopyramide improves systemic oxygen saturation in patients with TF through its negative inotropic action on the right ventricle.  (+info)

Serum alpha 1-acid glycoprotein, sialic acid, and protein binding of disopyramide in normal subjects and cardiac patients. (3/169)

AIM: To study influence of congestive heart failure (CHF) and acute myocardial infarction (AMI) on alpha 1-acid glycoprotein (AGP) and sialic acid (SA) concentration, and binding of AGP to disopyramide (Dis). METHODS: Sera from 85 healthy subjects, 6 patients with CHF, and 6 patients with AMI were determined by immunochemistry for AGP, by HPLC method for sialic acid (SA), and by ultrafiltration and HPLC for the free fraction of Dis. RESULTS: Serum AGP concentrations (g.L-1) were 0.74 +/- 0.16 (healthy), 1.18 +/- 0.40 (d 1, CHF) and 0.90 +/- 0.24 (d 14, CHF), 1.53 +/- 0.26 (d 5, AMI) and 1.08 (d 14, AMI). The free Dis were 1.76 +/- 0.62 (d 1) and 2.14 +/- 0.48 (d 14), in CHF patients, 1.66 +/- 0.52 (d 5) and 1.77 (d 14) in AMI patients. The changes of serum SA and AGP concentrations showed the same tendency. CONCLUSION: The free Dis in serum was affected by the change of AGP binding in CHF and AMI patients.  (+info)

Hypoglycemia induced by interaction between clarithromycin and disopyramide. (4/169)

A 59-year-old man receiving hemodialysis was hospitalized due to severe hypoglycemic attack. The patient had been treated with disopyramide (50 mg/day) because of paroxysmal atrial fibrillation. Hypoglycemia occurred after taking clarithromycin (CAM, 600 mg/day), a macrolide antibiotic. The serum disopyramide concentration reached 8.0 micrograms/ml (23.6 microM) in the presence of CAM, while it was 1.5 micrograms/ml before the addition of CAM. A 75 g oral glucose tolerance test and daily profiles of blood glucose value showed that blood glucose levels were significantly lower in the presence of CAM and disopyramide compared to that in the absence of these drugs. The Turner index in the presence of CAM and disopyramide was significantly higher than that in the absence of these drugs, suggesting that a toxic concentration of disopyramide enhanced insulin secretion, resulting in the induction of hypoglycemic attacks, in which the inhibitory effects of CAM on the hepatic chytochrome P-450 might be involved. QT and QTc intervals were prolonged in the presence of CAM and disopyramide, but torsades de points were not observed in this patient receiving nicorandil (15 mg/day). Thus, it should be taken into account that life-threatening hypoglycemia may result from the interaction between clarithromycin and disopyramide.  (+info)

Mechanism of transient outward K(+) channel block by disopyramide. (5/169)

The block of the transient outward K(+) current (I(to)) by disopyramide was studied in isolated rat right ventricular myocytes using whole cell patch-clamp techniques. Disopyramide at a concentration of 10 to 1000 microM reduced peak I(to) and accelerated the apparent rate of current inactivation. The onset of block was assessed using a double pulse protocol with steps from -70 to +50 mV. As the duration of the first (conditioning) pulse was increased from 1 to 50 ms, block was increased. Further prolongation of the conditioning pulse resulted in relief of block, which was nearly complete with a 1-s conditioning pulse. In the absence of drug, the recovery from inactivation of I(to) at -70 mV was fast and best fit with a single exponential function having a time constant of 33 +/- 13 ms. In contrast, in the presence of 100 microM disopyramide, recovery from apparent inactivation was biexponential with time constants of 35 +/- 13 ms and 7.16 +/- 1.5 s. The time course of the slow component was used to estimate recovery of channels from block by disopyramide. Recovery from block was voltage-dependent, suggesting that disopyramide was trapped by the open channel. Taken together, these results suggest that disopyramide rapidly blocks channels in the open state and that unblock occurs from the inactivated state.  (+info)

Transverse conduction capabilities of the crista terminalis in patients with atrial flutter and atrial fibrillation. (6/169)

OBJECTIVES: In this study, the transverse conduction capabilities of the crista terminalis (CT) were determined during pacing in sinus rhythm in patients with atrial flutter and atrial fibrillation. BACKGROUND: It has been demonstrated that the CT is a barrier to transverse conduction during typical atrial flutter. Mapping studies in animal models provide evidence that this is functional. The influence of transverse conduction capabilities of the CT on the development of atrial flutter remains unclear. METHODS: The CT was identified by intracardiac echocardiography. The atrial activation at the CT was determined during programmed stimulation with one extrastimulus at five pacing sites anteriorly to the CT in 10 patients with atrial flutter and 10 patients with atrial fibrillation before and after intravenous administration of 2 mg/kg disopyramide. Subsequently, atrial arrhythmias were reinduced. RESULTS: At baseline, pacing with longer coupling intervals resulted in a transverse pulse propagation across the CT. During shorter coupling intervals, split electrograms and a marked alteration of the activation sequence of its second component were found, indicating a functional conduction block. In patients with atrial flutter, the longest coupling interval that resulted in a complete transverse conduction block at the CT was significantly longer than that in patients with atrial fibrillation (285 +/- 49 ms vs. 221 +/- 28 ms; p < 0.05). After disopyramide administration, a transverse conduction block occurred at longer coupling intervals as compared with baseline (287 +/- 68 ms vs. 250 +/- 52 ms; p < 0.05). Subsequently, a sustained atrial arrhythmia was inducible in 15 of 20 patients. This was atrial flutter in three patients with previously documented atrial fibrillation and in eight patients with history of atrial flutter. Mapping revealed a conduction block at the CT in all of these patients. CONCLUSIONS: It was found that the CT provides transverse conduction capabilities and that the conduction block during atrial flutter is functional. Limited transverse conduction capabilities of the CT seem to contribute to the development of atrial flutter.  (+info)

Chronotropic, inotropic, dromotropic and coronary vasodilator effects of bisaramil, a new class I antiarrhythmic drug, assessed using canine isolated, blood-perfused heart preparations. (7/169)

The cardiovascular effects of a new class I antiarrhythmic drug, bisaramil, were examined using canine isolated, blood-perfused heart preparations. Bisaramil exerted negative chronotropic, inotropic and dromotropic effects as well as coronary vasodilator action, which are qualitatively the same as those of classical class I drugs. The selectivity of bisaramil for the intraventricular conduction vs the other cardiac variables was compared with that of disopyramide and flecainide. Bisaramil was the most selective for intraventricular conduction, while it was the least selective for ventricular muscle contraction. We conclude that bisaramil may become a useful antiarrhythmic drug with less cardiac adverse effects.  (+info)

Dynamic outflow obstruction due to the transient extensive left ventricular wall motion abnormalities caused by acute myocarditis in a patient with hypertrophic cardiomyopathy: reduction in ventricular afterload by disopyramide. (8/169)

A 65-year-old woman was admitted to the coronary care unit because of acute pulmonary edema. Immediate 2-dimensional and Doppler echocardiograms revealed extensive left ventricular wall motion abnormalities and left ventricular hypertrophy with extreme outflow obstruction. Although an ECG showed ST-segment elevation in the anterolateral leads, a coronary arteriogram revealed normal epicardial arteries. Heart failure was relieved after diminishing the dynamic outflow obstruction with disopyramide administration. An endomyocardial biopsy from the right ventricle on the 8th hospital day showed borderline myocarditis. Wall motion abnormalities gradually normalized within 2 weeks. It is speculated that her pulmonary edema would not have been relieved so readily without the immediate reduction in ventricular afterload by disopyramide. These clinical changes over time were observed with serial echo-Doppler examinations.  (+info)

We studied the interaction of disopyramide, quinidine, and procainamide with cardiac muscarinic receptors. In electrophysiological experiments, the effects of disopyramide, quinidine, procainamide, and atropine were determined on spontaneously depolarizing guinea pig right atria (GPRA) both in the presence and absence of pharmacologically induced (physostigmine) cholinergic stimulation. All four agents demonstrated a concentration-dependent antagonism of the negative chronotropic effects of physostigmine. The order of anticholinergic potency was atropine greater than disopyramide greater than quinidine greater than procainamide. The ability of disopyramide to antagonize the physostigmine induced slowing was stereoselective, (+)disopyramide greater than (-)disopyramide. In contrast, the ability of quinidine to antagonize the negative chronotropic effects of physostigmine was non-stereoselective, quinidine = quinine. In parallel experiments, we studied the ability of disopyramide, quinidine, ...
Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication used in the treatment of ventricular tachycardia. It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agent. Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. Disopyramide also has an anticholinergic effect on the heart which accounts for many adverse side effects. Disopyramide is available in both oral and intravenous forms, and has a low degree of toxicity. Disopyramides Class 1a activity is similar to that of quinidine in that it targets sodium channels to inhibit conduction. Disopyramide depresses the increase in sodium permeability of the cardiac myocyte during Phase 0 of the cardiac action potential, in turn decreasing the inward sodium current. This results in an increased threshold for excitation and a decreased upstroke velocity. Disopyramide prolongs the PR interval by lengthening both the QRS and ...
The isolated blood-perfused preparations of canine atrium were suspended in a bath and perfused with arterial blood led from the carotid artery of the heparinized donor dog. Disopyramide caused dose-related negative chronotropic and inotropic effects in a dose range of 30-1000 microgram when injected directly into the cannulated sinus node artery of the isolated atrium. The order of potencies for inducing the negative chronotropic effect in isolated atrium preparations was verapamil greater than propranolol greater than lidocaine = quinidine greater than phenytoin greater than or equal to disopyramide greater than procainamide. On the other hand, the order of potencies for inducing the negative inotropic effect was verapamil = propranolol greater than lidocaine greater than or equal to phenytoin greater than disopyramide greater than procainamide greater than or equal to quinidine. When disopyramide (1 mg/kg or 3 mg/kg) was administered i.v. into the jugular vein of the donor dog, the systemic ...
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Disopyramide phosphate | C21H32N3O5P | CID 30928 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Since disopyramide was introduced 5 years ago, the therapeutic spectrum of this drug in treating patients with ventricular and atrial arrhythmias has been found to be similar to that of the other type I antiarrhythmic drugs, quinidine and procainamide. Disopyramide has the potential to suppress sinus node function and, therefore, must be used cautiously in patients with the sick sinus syndrome. The available data indicate that it can be used safely in patients with bundle branch block and firstdegree or type I second-degree atrioventricular block. Disopyramide has been found at times to precipitate ventricular tachycardia or ventricular fibrillation. Because this drug often causes decompensation in patients with congestive heart failure, it must be used very cautiously, if at all, in such patients. ...
1 The effects of rifampicin, phenytoin, and disopyramide treatments on the metabolism of disopyramide were studied in patients and volunteers. 2 Rifampicin treatment markedly increased the metabolism of disopyramide. 3 Phenytoin had effects similar to those of rifampicin. The effect subsided in 2 we …
DESCRIPTION Norpace (disopyramide phosphate) is an antiarrhythmic drug available for oral administration in immediate-release and controlled-release capsules containing 100 mg or 150 mg of disopyramide base, present as the phosphate. The ...
Added November 1, 2014; Updated November 30, 2014; January 1, 2015; January 31, 2015; May 8, 2015; May 15, 2015; May 29, 2015; June 12, 2015; June 20, 2015; July 17, 2015; August 5, 2015; September 17, 2015; October 19, 2015; November 4, 2015; December 7, 2015; December 31, 2015. ...
Common side effects of Disopyramide includes dry mouth and eyes, blurred vision, constipation. If you experience any of these, inform your Cardiologist.
Find information on Disopyramide (Norpace) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
As this eMedTV page explains, a doctor may prescribe 100 mg of generic disopyramide capsules to treat certain heart rhythm problems. This article takes a brief look at the generic versions of this medication and offers a link to more detailed information.
The side effect profile ofhas been well established. Anticholinergic symptoms are most common, but cardiac toxicity is of greatest concern. In particular, the negative inotropic activity and proarrhythmic potential of disopyramide limits its use in s
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
Visit your doctor or health care professional for regular checks on your progress.. Check your heart rate and blood pressure regularly while you are taking this medicine. Ask your doctor or health care professional what your heart rate and blood pressure should be, and when you should contact him or her. Your doctor or health care professional also may schedule regular tests to check your progress.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.. This medicine may cause dry eyes and blurred vision. If you wear contact lenses ...
Check your heart rate and blood pressure regularly while you are taking this medicine. Ask your doctor or health care professional what your heart rate and blood pressure should be, and when you should contact him or her. Your doctor or health care professional also may schedule regular tests to check your progress.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.. This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the ...
Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations. ...
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (Multum) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multums drug information does not endorse drugs, diagnose patients or recommend therapy. Multums drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug ...
Avoid ivabradine; disopyramide (within 48hrs before or 24hrs after verapamil); quinidine in cardiomyopathy. Limit simvastatin dose to 10mg/day or lovastatin to 40mg/day; may need to reduce initial and maintenance dose for other CYP3A4 substrates (eg, atorvastatin). Potentiates alcohol, β-blockers (monitor closely), other antihypertensives (monitor), theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine, doxorubicin. Consider reducing concomitant digoxin dose; monitor periodically; discontinue if toxicity suspected. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir), grapefruit juice. Antagonized by CYP3A4 inducers (eg, rifampin, phenobarbital). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor lithium levels. Monitor heart rate when concomitant clonidine. Concomitant mTOR inhibitors (eg, sirolimus, temsirolimus, everolimus): consider dose reductions of both drugs. ...
Make sure your doctor knows if you are using digoxin (Digitek®, Lanoxin®), guanethidine (Ismelin®), reserpine, medicine to treat depression (such as fluoxetine, paroxetine, Paxil®, or Prozac®), medicine for heart rhythm problems (such as disopyramide, propafenone, quinidine, Norpace®, or Rhythmol®), or other blood pressure medicine (such as clonidine, diltiazem, verapamil, Calan®, Cardizem®, Cartia®, Catapres®, Isoptin®, Tiazac®, or Verelan®). Tell your doctor if you are also using numbing medicines (such as cyclopropane, ether, or trichloroethylene) or insulin or diabetes medicine that you take by mouth (such as glyburide, metformin, Actos®, or Glucotrol ...
Make sure your doctor knows if you are using digoxin (Digitek®, Lanoxin®), guanethidine (Ismelin®), reserpine, medicine to treat depression (such as fluoxetine, paroxetine, Paxil®, or Prozac®), medicine for heart rhythm problems (such as disopyramide, propafenone, quinidine, Norpace®, or Rhythmol®), or other blood pressure medicine (such as clonidine, diltiazem, verapamil, Calan®, Cardizem®, Cartia®, Catapres®, Isoptin®, Tiazac®, or Verelan®). Tell your doctor if you are also using numbing medicines (such as cyclopropane, ether, or trichloroethylene) or insulin or diabetes medicine that you take by mouth (such as glyburide, metformin, Actos®, or Glucotrol ...
Cytokinetics Announces Cohort 3 of REDWOOD-HCM is Open to EnrollmentNext Cohort to Enroll Patients on Background Therapy of Disopyramide - read this article along with other careers information, tips and advice on BioSpace
Vitamins and medications are chemical compounds that affect the bodys metabolic function. Just as medications may have toxic interactions when taken together, they may also have toxic interactions when taken with vitamins. While many patients discuss their prescribed medications with their doctors, vitamin supplements sold over the counter often are not considered. Patients are…
Effects of antiarrhythmic drugs on HCN4 channel currents in HEK293 cells Effects of type Ia antiarrhythmic drugs, quinidine, disopyramide, and cibenzoline, on the HCN4 channel current were examined in HEK293 cells. Quinidine developed a simple reduction of the HCN4 channel current at a concentration of 30 uM. The assessed IC50 value of quinidine for inhibiting the HCN4 channel current purchase Celecoxib was 78. 3 uM, which was greater than the therapeutic concentration of quinidine. Cibenzoline and disopyramide also inhibited the HCN4 channel current weakly, with calculated IC50 values of 46. 249 and 8 uM, respectively, which were both more than the therapeutic concentrations. Ramifications of class Ib anti-arrhythmic medications, aprindine, and lidocaine, mexiletine, to the HCN4 channel current were also examined in HEK293 cells. Lidocaine at a concentration Organism of 30 uM inhibited the HCN4 channel current, specially at hyperpolarizing currents below 100 mV. The inhibitory effect of ...
The antiarrhythmic, electrophysiologic and hemodynamic effects of a new antiarrhythmic agent, ACC-9358, were evaluated. In anesthetized dogs, ACC-9358 converted ouabain-induced ventricular tachycardia to normal sinus rhythm at a cumulative dose equal to encainide or flecainide and less than disopyramide. In 24-hr coronary artery ligated dogs, ACC-9358 suppressed spontaneous ventricular arrhythmias for up to 6 hr after oral or i.v. administration. The antiarrhythmic effect and plasma concentrations of ACC-9358 correlated well for both oral (r = 0.88) and i.v. (r = 0.87) administration. ACC-9358, flecainide and disopyramide were equieffective in converting crush-stimulation-induced atrial flutter in anesthetized dogs to normal sinus rhythm. In alpha-chloralose-anesthetized, closed-chest dogs, ACC-9358 slowed impulse conduction through the atria, atrioventricular node, His-Purkinje system and ventricles and prolonged atrial functional refractory period. In conscious dogs, ACC-9358 increased heart ...
The cardiovascular effects of a new class I antiarrhythmic drug, bisaramil, were examined using canine isolated, blood-perfused heart preparations. Bisaramil exerted negative chronotropic, inotropic and dromotropic effects as well as coronary vasodilator action, which are qualitatively the same as those of classical class I drugs. The selectivity of bisaramil for the intraventricular conduction vs the other cardiac variables was compared with that of disopyramide and flecainide. Bisaramil was the most selective for intraventricular conduction, while it was the least selective for ventricular muscle contraction. We conclude that bisaramil may become a useful antiarrhythmic drug with less cardiac adverse effects.. ...
Three hundred fifty-eight of 429 (83%) consecutive patients with acute myocardial infarction (MI) and a normal PR interval received various antiarrhythmic drugs (AD), including lidocaine and/or procainamide, quinidine, digoxin, propranolol or disopyramide. There was no significant difference in the incidence of progression to any degree of atrioventricular (AV) block or to higher degrees of AV block (Mobitz II or third-degree AV block) between those treated and not treated with AD: 38 of 358 (11%) and six of 358 (1.7%) with AD vs 11 of 71 (15%) and two of 71 (2.8%) in the untreated group, respectively. Similarly, there was no significant difference in progression between treated and untreated patients with anterior MI, 14 of 144 (10%) vs five of 32 (16%); inferior MI, 21 of 111 (19%) vs five of 26 (19%), or subendocardial MI, three of 103 (3%) vs one of 12 (8%). Bundle branch block (BBB) (without AV block) was initially present in 89 of 249 (21%). The incidence of AV block (seven of 24, 30%) was ...
AIMS: Short QT syndrome (SQTS) is an inherited disorder associated with abnormally abbreviated QT intervals and an increased incidence of atrial and ventricular arrhythmias. SQT1 variant (linked to the rapid delayed rectifier potassium channel current, IKr) of SQTS, results from an inactivation-attenuated, gain-of-function mutation (N588K) in the KCNH2-encoded potassium channels. Pro-arrhythmogenic effects of SQT1 have been well characterized, but less is known about the possible pharmacological antiarrhythmic treatment of SQT1. Therefore, this study aimed to assess the potential effects of E-4031, disopyramide and quinidine on SQT1 using a mathematical model of human ventricular electrophysiology. METHODS: The ten Tusscher et al. biophysically detailed model of the human ventricular action potential (AP) was modified to incorporate IKr Markov chain (MC) formulations based on experimental data of the kinetics of the N588K mutation of the KCNH2-encoded subunit of the IKr channels. The modified ...
bromocriptine was shown to cure pituitary. (10 mg/kg/day) nor desipramine (10 mg. receptor agonist, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane.Bromocriptine or for. Discount coupon does lower prolactin dostinex 0 5mg tablets dostinex product information and thc. 0 5 mg 8. Guercmorteo price.. . 1 g on the first day and 0.5 g daily from 2 to 5. day and 10 mg / kg, with 2 to 5. acid, disopyramide, bromocriptine, phenytoin, oral.The device of claim 2 wherein said neurotransmitter is the dopamine agonist bromocriptine. NaPO 4, 0.2 M EDTA, 212 mg/L. a flow rate of 2.5 ml/minute.. Meilleur Site Pour Achater Bromocriptine 2.5 Mg Rapide. Comment Commander Parlodel Ou Acheter Bromocriptine 2.5 En Ligne Prix Bromocriptine Pharmacie Forum ...
Find details on Heart: first degree atrioventricular block in dogs including diagnosis and symptoms, pathogenesis, prevention, treatment, prognosis and more. All information is peer reviewed.
Do not take this medicine with any of the following: -cisapride -disopyramide -dofetilide -grapefruit juice -hawthorn -pimozide -red yeast rice This medicine may also interact with the following medications: -barbiturates such as phenobarbital -cimetidine -cyclosporine -lithium -local anesthetics or general anesthetics -medicines for heart rhythm problems like amiodarone, digoxin, flecainide, procainamide, quinidine -medicines for high blood pressure or heart problems -medicines for seizures like carbamazepine and phenytoin -rifampin, rifabutin or rifapentine -theophylline or aminophylline. This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.. ...
Pancreatitis. The key to choosing appropriate therapeutic lifestyle changes and the patienthis on appropriate lifestyle modifications that may cause brown scaling. It should proceed in parallel with improvement in his diaper area. Kuehn bm. Treatment nonpharmacologic treatment modalities is beyond the scope of this subject will focus on functional genomics and translational biology, and prognostic actors in the transport team to arrive, the patient in the. Calcium gluconate is preferred over surgically inserted shunts because they may be incorrect. B. Other tesu such as sleep apnea drugs adenosine fluoxetine amiodarone halothane blockers isradipine cisplatin ketamine citalopram neostigmine clonidine nicardipine cocaine nitroglycerin dexmedetomidine paclitaxel digoxin propafenone diltiazem propofol dipyridamole remifentanil disopyramide sotalol donepezil succinylcholine dronedarone thalidomide flecainide verapamil clinical presentation and diagnosis of latent infection two thirds of the placement ...
Its best to stay away from alcoholic beverages furosemide when you take Levitra, as it can aggravate several of your adverse effects. The signs and symptoms of BPH could be triggered by a tensing of the bigger muscle in the prostate gland avodart which blocks the passage of pee. Azithromycin celexa is an oral macrolide antibiotic made use of for the procedure of bacteria-induced infections. This is to make certain you are making use of the medicine albuterol for sale as it was recommended as component of your treatment. Your doctor requires to recognise if you are receiving treatment for heart rhythm disorder cheap tretinoin cream 0.25 or making use of such medicines as amiodarone, bretylium, disopyramide, procainamide, sotalol, quinidine, as these could interfere with Levaquin. Those negative side effects are not disappearing and need to be treated effectively. Ensure you ask your physician any sort of inquiries you have buy erythromycin without prescription before the procedure and be started ...
They pick up object from its spread. Personal treatment and p-drugs are outlined in this manner from generation to generation of the missed pill , tranq , and increasing demands coupled with calm and call it the unpleasure principle (standard edition, iii, pp. [from greek apo away + movere, motum to move the lower uterine segment that is defined as the classic claw hand. But can make the incision site, often it is effective in dandruff and seborrhoeic dermatitis these conditions are that they are less hepatotoxic. A single dose once a week for 4 more weeks. Precognitive clairvoyance n. Extra-sensory perception of the upper gyrus of the. Quinidine, procainamide, disopyramide; (ib) those which are transmitted by quartz crystals (from which mannitol tends to flatten the endometrium, for example, the practice of the neck; and should generally be administered iv, it can cause marked diuresis when given orally. Con rms it. This assumption also leads to accumulation of changes in hours of duration of ...
DO NOT TAKE THIS MEDICINE if you are also taking propafenone or pimozide. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking anticoagulants (such as warfarin), digoxin, nelfinavir, cyclosporine, ergotamine, hexobarbital, phenytoin, rifampin, theophylline, triazolam, certain medicines for high cholesterol (such as lovastatin), medicines for irregular heartbeat (such as amiodarone, disopyramide, quinidine, or procainainide) , or medicines that may affect your heartbeat. Ask your doctor if you are unsure if any of the medicines you are taking may affect your heartbeat. Inform your doctor of any other medical conditions including irregular heartbeat, kidney problems, liver problems, allergies, pregnancy or breastfeeding. TO CLEAR UP YOUR INFECTION COMPLETELY, continue taking this medicine for the full course of treatment even if you feel better in a few days. CAUTIONS: DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient ...
Saini ak, regmi s, seth a, narayan r, singh p, nayyar r. Outcomes of robot-assisted radical prostatectomy: Predictors of success include imipramine should never skin viagra and cialis cancer be overlooked. Figure 71.5 laparoscopic ultrasound during the spray about 7 21 31 30 % washout is indicative of liver cells and modeling cancer in high-risk patients with cardiac disease and neurologic disorders, retinal diseases, and patients with. Typically, between 12 anomalies such as disopyramide, ecainide, quinidine, adenosine is an alcohol base should not be used in patients with urolithiasis. 2010;25:1100 8. 28. The thromboembolic condition will be needed to visualize the extent of absorption and adminis- outdoor lifestyle. When you drop a hammer on your own. 2009;113:1022 4. 7. Feldman ls, sherman v, fried gm. The reader should giardiasis be able to enjoy one of them, take oral linco- mycin with a relatively common problem when compared with other drugs of abuse c h a p t e r 41 s e v e n objectives ...
Be sure to mention any of the following anticoagulants blood thinners such as warfarin coumadin ; antidepressants; antifungals such as ketoconazole nizoral , itraconazole sporanox , or voriconazole vfend ; aspirin and other nsaids such as ibuprofen advil, motrin and naproxen aleve, naprosyn ; certain medications for human immunodeficiency virus hiv or acquired immunodeficiency syndrome aids such as atazanavir reyataz , indinavir crixivan , nelfinavir viracept , ritonavir norvir, in kaletra , and saquinavir invirase ; cimetidine tagamet ; cisapride propulsid ; clarithromycin biaxin, in prevpac ; cyclosporine neoral, sandimmune ; danazol danocrine ; delavirdine rescriptor ; dexamethasone decadron ; digoxin digitek, lanoxin, lanoxicaps ; diltiazem cardizem, dilacor, tiazac ; diuretics; disopyramide norpace ; dofetilide tikosyn ; erythromycin e ...
In a dthen 30 mg prevacid of a 46-mg paper with exelon, the disopyramide blown vomiting, incontinence, hypertension, scavenger retardation, and fluorometholone of consciousness. Seeing my 7 prevacid 30mg taken for ulcer scored angiotension in the far wit while i drove us conclusively to my sulphamethizole (where the patients were) topically iuprofen me undertake like a simplex person, and i enfeebled out, quicly readjusting that these cues had ususually arteriosus dealt over my life. If cutting codimal ph syrup for an burped Prevacid of time, do orginally suddenly xinafoateabate emptying codimal ph syrup without your doctors approval. Anyways its writingaccompanying to scream aunty and i isolate he is harnessing he buy prevacid want shrug but simulate into habitforming an hanging and overindulge his parents. 4?mg was added for the long seven defensas of each period. Despues de buy nexium de constent fluvoxamine, embellished willin esperar concern lo forpatients 14 d?as crises de que implant ...
Background Cognitive decline is common in Parkinsons disease (PD). Although some of the aetiological factors are known, it is not yet known whether drugs with anticholinergic activity (AA) contribute to this cognitive decline. Such knowledge would provide opportunities to prevent acceleration of cognitive decline in PD.. Objective To study whether the use of agents with anticholinergic properties is an independent risk factor for cognitive decline in patients with PD.. Methods A community-based cohort of patients with PD (n=235) were included and assessed at baseline. They were reassessed 4 and 8 years later. Cognition was assessed using the Mini-Mental State Examination (MMSE). A detailed assessment of the AA of all drugs prescribed was made, and AA was classified according to a standardised scale. Relationships between cognitive decline and AA load and duration of treatment were assessed using bivariate and multivariate statistical analyses.. Results More than 40% used drugs with AA at ...
The article by Coumbe et al1 in this journal is most welcome. It throws more light on a vexed difference between North American and European pacemaker practice, where the two regions guidelines for pacemaker implantation differ profoundly.2-4 Mobitz type 1 atrioventricular block (AVB) in North America is classified as a Class 3 indication in the most recent guidelines for permanent pacing2 unless the block is demonstrated on electrophysiological study to be below the his bundle. In practice, however, electrophysiological assessments are rarely performed. Furthermore, a very recent focused update of the North American guidelines does not change the above recommendation.3 By contrast, the European Society of Cardiology (ESC) guidelines4 published closely related in time to the full North American version2 recommends pacing as a Class 2A indication.. The discrepancy between current North American and European recommendations is based, first, on the correct observation of the benign nature of ...
A drug that blocks the effects of acetylcholine, a substance produced by the body that is responsible for certain nervous system activities (parasympathetic). Drugs with anticholinergic effects (including antidepressants, antihistamines, antipsychotics, drugs for intestinal problems, antiparkinsonians) inhibit the secretion of acid in the stomach, slow the passage of food through the digestive system, inhibit the production of saliva, sweat, and bronchial secretions, and increase the heart rate and blood pressure. Adverse effects of these drugs include dry mouth, constipation, difficulty urinating, confusion, worsening of glaucoma, blurred vision, and short-term memory problems ...
Benzodiazepines and drugs with strong anticholinergic effects have been linked to Alzheimers disease in people who take them. There are alternatives to both types.
Taking flecainide can help stabilize certain types of irregular heart rhythms. This part of the eMedTV Web site features more details on this antiarrhythmia medicine, including what it is prescribed for, dosing instructions, side effects, and more.
Ischemia-Related Subcellular Redistribution of Sodium Channels Enhances the Proarrhythmic Effect of Class I Antiarrhythmic Drugs: A Simulation Study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
A normal-phase (NP) TLC method has been established for separation of the five antiarrhythmics - disopyramide, flecainide, mexiletine, tocainide, and verapamil. The analysis was performed in horizontal chambers on aluminum oxide 60 F 254 and silica gel 60 F 254 TLC plates. The best mobile phases for separation of the compounds were tetrahydrofuran-hexane-25% ammonia, 5 + 4.8 + 0.2 ( v/v ), on the alumina plates and chloroform-tetrahydrofuran-ethanol-25% ammonia, 8.1 + 1.9 + 2 + 0.1 ( v/v ), on the silica plates. The substances were identified by use of different reagents and under UV irradiation at λ = 254 nm. Quantification of mexiletine hydrochloride in Mexicord capsules was performed densitometrically at λ = 210 nm. A good correlation coefficient ( r = 0.9974) was obtained for the calibration plot constructed in the concentration range 20-45 μg per band. The active substance was extracted from the formulation with methanol (recovery 97.01 ± 2.39%, mean ± SD ). The RSD expressing the ...
Hypertrophic cardiomyopathy (HCM) is a condition in which a portion of the heart becomes thickened without an obvious cause. This results in the heart being less able to pump blood effectively. Symptoms vary from none to feeling tired, leg swelling, and shortness of breath. It may also result in chest pain or fainting. Complications include heart failure, an irregular heartbeat, and sudden cardiac death. HCM is most commonly inherited from a persons parents. It is often due to mutations in certain genes involved with making heart muscle proteins. Other causes may include Fabry disease, Friedreichs ataxia, and certain medications such as tacrolimus. It is type of cardiomyopathy, a group of diseases that primarily affects the heart muscle. Diagnosis often involves an electrocardiogram, echocardiogram, and stress testing. Genetic testing may also be done. Treatment may include the use of beta blockers, diuretics, or disopyramide. An implantable cardiac defibrillator may be recommended in those ...
See Contraindications. Class IA (disopyramide, quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmics, or other drugs known to prolong QT interval: not recommended. Sildenafil, tadalafil, vardenafil: not recommended. Antagonized by CYP3A inducers (eg, efavirenz, nevirapine, rifampicin, rifabutin, rifapentine, etravirine); use alternative antibacterial treatment. Doses ,1000mg/day should not be coadministered with protease inhibitors. Separate zidovudine dose by at least 2hrs. Potentiated by CYP3A inhibitors (eg, itraconazole, saquinavir, atazanavir, ritonavir). Concomitant atazanavir: see Adults; consider alternative antibacterial therapy for indications other than MAC. May potentiate theophylline, omeprazole, phenytoin, digoxin, midazolam, alprazolam, triazolam, cyclosporine, hexobarbital, tacrolimus, alfentanil, bromocriptine, valproate, carbamazepine, tolterodine, itraconazole, methylprednisolone, cilostazol, vinblastine, quetiapine, maraviroc; monitor these ...
The LD50 values were determined for cardiovascular drugs in chick embryos at different developmental stages in order to obtain a more precise injection stage for fertile eggs of White Leghorn chickens for the prediction in rodents. First, time-course changes in the weight of fertile eggs, their air sac volume, and weight of each egg component were measured after the initiation of incubation. The weight of whole eggs decreased with incubation, while air sac volume increased. The chick embryos weight increased with decreases in albumen weight. These findings suggest that decreases in whole egg weight are due to decreases in water in the eggs. When the maximum volume of physiological saline or CMC-Na solution was injected into the air sac on different days of incubation the bulk of the vehicle did not prove to be toxic to the chick embryos. Next, several cardiovascular drugs, i.e., aloprenolol, piretanide, dipyridamol, lidocaine, propranolol, canrenoate, disopyramide and reserpine were injected ...
on a cognitive test and 1.1-percent on a measure of routine activities one can perform for themselves (another measure of intact cognition). Unfortunately, cognitive decline that is due to anticholinergic medications is often overlooked because most medications listed in the accompanying Table would not necessarily, alone, account for a striking decline in memory or other cognitive function. But, the cumulative impact of consuming multiple medications with anticholinergic effects may be significant, resulting in unnecessary distress among patients, families and physicians alike. While these findings are only preliminary, they permit physicians and patients to semi-quantitatively account for the anticholinergic effects of a patients medications when the patient complains of memory and other cognitive problems. If you are suffering from a troubling decline in one of your cognitive functions, the first thing you and your physician should do is take a look at your medication list. The answer may be ...
TY - JOUR. T1 - Effects of bisaramil on coronary-occlusion-reperfusion injury and free-radical-induced reactions. AU - Paróczai, Margit. AU - Roth, Elizabeth. AU - Matos, Gábor. AU - Temes, Gyula. AU - Lantos, János. AU - Karpati, Egon. PY - 1996/6. Y1 - 1996/6. N2 - The aim of this study was to determine whether bisaramil - an antiarrhythmic compound under clinical investigation - influences the reperfusion-induced arrhythmias and biochemical parameters characterizing occlusion-reperfusion-induced free-radical reactions. The left descending coronary artery (LAD) was occluded for 60 min in anaesthetized dogs followed by one hour of reperfusion. Blood samples were taken at different times of the occlusion and reperfusion for the determination of plasma concentration of malondialdehyde (MDA), reduced (GSH) and oxidized glutathione (GSSG); furthermore of the activity of catalase and superoxide dismutase (SOD). Free-radical generating capacity of polymorph neutrophil granulocytes (PMN) was also ...
Comprehensive disease interaction information for Triaminic Thin Strips Night Time Cold & Cough. Includes Antihistamines - Anticholinergic Effects.
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By slowing down electrical impulses in the heart, flecainide can help prevent certain heart rhythm problems. This eMedTV resource describes approved uses of flecainide, and also discusses situations where the drug may be prescribed for unapproved reasons.
disopyramide. 3737-09-5 C21H30ClNO8. doronine. 60367-00-2 ...
DISOPYRAMIDE 160. DOCETAXEL 161. DOMPERIDONE 162. DONEPEZIL HYDROCHLORIDE 163. DOPAMINE HYDROCHLORIDE 164. DOTHIEPIN ...
Class Ia agents include quinidine, procainamide and disopyramide. Class Ib antiarrhythmic agents are sodium channel blockers. ...
Procainamide, quinidine and disopyramide are Class Ia agents. Class 1b drugs lengthen phase 3 repolarization. They include ...
Some commercial products include pyrithione, pyripropoxyfen, chlorphenamine, and disopyramide. In these conversions, chloride ...
IA組:阻斷快速性Na+通道(Quinidine (Quinidex®));(Procainamide (Pronestyl®));Disopyramide (Norpace®)) ...
For people whose symptoms are not relieved by the above treatments, disopyramide can be considered for further symptom relief. ... Medications may include the use of beta blockers or disopyramide. An implantable cardiac defibrillator may be recommended in ...
... is an antiarrhythmic drug that is made from disopyramide. Cook, CS; Rozek, LF; Stolzenbach, J; Anderson, S; ...
Rythmodan (disopyramide). Decis (deltamethrin). Surgam (tiaprofenic acid). Claforan (cefotaxime sodium). Mifegyne (mifepristone ...
... disopyramide, sotalol, amiodarone, amitriptyline, chlorpromazine, erythromycin) and/or congenital syndromes. The prolongation ...
Patients who have low CYP3A activity and are also concurrently taking other medications such as disopyramide, which can lead to ... the potassium channel blocking activity takes precedence over the sodium channel blocking activity Disopyramide Flecainide ...
... disopyramide, and, in health-care settings where a syncope is anticipated, atropine epinephrine (adrenaline). For people with ...
The concomitant use of the following medications is contraindicated with ketoconazole tablets: methadone, disopyramide, ...
... disopyramide MeSH D03.383.725.259 - doxylamine MeSH D03.383.725.385 - indinavir MeSH D03.383.725.394 - isonicotinic acids MeSH ...
... in which a male is born with two penises Disopyramide Drug product Degtyaryov machine gun (Degtyarova pekhotnyi), a Soviet ...
C01AC01 G-strophanthin C01AC03 Cymarin C01AX02 Peruvoside C01BA01 Quinidine C01BA02 Procainamide C01BA03 Disopyramide C01BA04 ...
... disopyramide (Norpace), propafenone (Rythmol) and carvedilol (Coreg) Amlodipine: Grapefruit increases the available amount of ...
Gastric dumping syndrome Drug induced hyperinsulinism Sulfonylurea Aspirin Pentamidine Quinine Disopyramide Bordetella ...
... disopyramide, procainamide (class I antiarrhythmic agents) Prior use of amiodarone hydrochloride Adams-Stokes syndrome Wolff- ...
Disophrol disopyramide (INN) disoxaril (INN) Dispermox distigmine bromide (INN) disufenton sodium (USAN) disulergine (INN) ...
... disopyramide, cisapride, domperidone, rifampicin or ketoconazol. It is also contraindicated in people with epilepsy or badly ...
... disopyramide) Antidepressants (e.g. venlafaxine) Antihistamines (e.g. levocabastine and chlorphenamine) Antimalarial ...
Calcium channel blockers Diltiazem Verapamil Class IA antiarrhythmics such as Quinidine Procainamide Disopyramide Class IC ...
... disopyramide) Class Ib - Sodium channels (lidocaine, phenytoin, mexiletine, tocainide) Class Ic - Decrease conductivity ( ...
... is available in both oral and intravenous forms, and has a low degree of toxicity. Disopyramide's Class 1a ... Disopyramide is most often administered with beta-blockade. When used in patients resistant to beta-blockade, disopyramide is ... Disopyramide has been actively used for more than 30 years. Disopyramide administration for obstructive HCM has a IIa ... to every patient begun on disopyramide. This combination increases acceptance of higher disopyramide dosing, important since ...
... is a member of the sodium channel blocking class of antiepileptic drugs.[60] This may suppress the release of glutamate and aspartate, two of the dominant excitatory neurotransmitters in the CNS.[61] It is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs,[62] but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not, possibly on account of its sigma receptor activity. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties.[63] It is a triazine derivate that inhibits voltage-sensitive sodium channels, leading to stabilization of neuronal membranes. It also blocks L-, N-, and P-type calcium channels and ...
The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). In some nations, including Australia, domperidone is used off-label, based on uncertain and anecdotal evidence of its usefulness, as a therapy for mothers who are having difficulty breastfeeding.[24][25] In the United States, domperidone is not approved for this or any other use.[26][27] A study called the EMPOWER trial was designed to assess the effectiveness and safety of domperidone in assisting mothers of preterm babies to supply breast milk for their infants.[28] The study randomized 90 mothers of preterm babies to receive either domperidone 10 mg orally three times daily for 28 days (Group A) or placebo 10 mg orally three times daily for 14 days followed by domperidone ...
... (DHP) is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure. ...
InChI=1S/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27) ...
... (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.[1] It is not effective for absence or myoclonic seizures.[1] It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalised seizures.[4] Common side effects include nausea and drowsiness.[1] Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion.[1] It should not be used in those with a history of bone marrow problems.[1] Use during pregnancy may cause harm to the baby; however, stopping the medication in pregnant women with seizures is not recommended.[1] Its use during breastfeeding is not recommended.[1] Care should be taken in those with either kidney or liver problems.[1] Carbamazepine was discovered in 1953 by Swiss chemist Walter ...
Disopyramide: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Disopyramide helps control your condition but will not cure it. Continue to take disopyramide even if you feel well. Do not ... Disopyramide comes as a capsule and an extended-release (long-acting) capsule to take by mouth. Disopyramide capsules may be ... Before taking disopyramide,. *tell your doctor and pharmacist if you are allergic to disopyramide, any other medications, or ...
Disopyramide capsules are also available without a brand name, ie as the generic medicine. Disopyramide is used to control ... Rythmodan capsules and injection both contain the active ingredient disopyramide, which is a type of medicine called an anti- ... Disopyramide capsules are also available without a brand name, ie as the generic medicine. Disopyramide is used to control ... Disopyramide capsules are also available without a brand name, ie as the generic medicine. Disopyramide is used to control ...
Rythmodan retard tablets contain the active ingredient disopyramide, which is a type of medicine called an anti-arrhythmic. ... Rythmodan retard (disopyramide). Rythmodan retard tablets contain the active ingredient disopyramide, which is a type of ... Disopyramide is used correct irregular heartbeats and maintain heart rhythms.. How do I take it?. *Rythmodan retard tablets are ... The amount of disopyramide in the blood may be decreased by the following medicines and this may reduce the effectiveness of ...
Disopyramide is available in both oral and intravenous forms, and has a low degree of toxicity. Disopyramides Class 1a ... Disopyramide is most often administered with beta-blockade. When used in patients resistant to beta-blockade, disopyramide is ... Disopyramide has been actively used for more than 30 years. Disopyramide administration for obstructive HCM has a IIa ... to every patient begun on disopyramide. This combination increases acceptance of higher disopyramide dosing, important since ...
Get an overview of DISOPYRAMIDE PHOSPHATE (capsule), including warnings and precautions, directions, and the names of other ...
Disopyramide is used to treat life-threatening irregular heartbeat patterns. Disopyramide may also be used for purposes not ... Disopyramide affects the way that your heart beats. ... Disopyramide 100 mg-TEV. slide 1 of 2, Disopyramide 100 mg-TEV, ... What is disopyramide?. Disopyramide affects the way that your heart beats.. Disopyramide is used to treat life-threatening ... What is the most important information I should know about disopyramide?. You should not use disopyramide if you have long QT ...
Detailed Disopyramide dosage information for adults. Includes dosages for Arrhythmias; plus renal, liver and dialysis ... disopyramide, Mexitil, Calan SR, Norpace, Isoptin SR, Pronestyl, Nexterone, Ethmozine, Verelan PM, More... ...
Disopyramide official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, ... How is Disopyramide Supplied. Disopyramide Phosphate Capsules (equivalent to 100 mg Disopyramide base) are opaque orange ... Disopyramide phosphate capsules (equivalent to 100 mg Disopyramide Base) and Disopyramide phosphate capsules (equivalent to 150 ... Disopyramide. Generic Name: Disopyramide phosphate. Dosage Form: capsule. Medically reviewed by Drugs.com. Last updated on Oct ...
This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine ...
Disopyramide shares electrophysiologic properties with quinidine and procainamide. Up to 80% of oral dose is absorbed. Half- ... Metabolite N-desisopropyl disopyramide is also pharmacologically active. Concomitant treatment with phenytoin may lead to ... decreased serum levels of disopyramide. There may be cumulative effect with other Class I antiarrhythmic drugs (lidocaine, ...
Find patient medical information for Disopyramide Phosphate Oral on WebMD including its uses, side effects and safety, ... Other medications can affect the removal of disopyramide from your body, which may affect how disopyramide works. Examples ... disopyramide phosphate 150 mg capsule. color. buff,scarlet. shape. oblong. imprint. 93 3129, 93 3129. This medicine is a buff ... disopyramide phosphate 100 mg capsule. color. orange. shape. oblong. imprint. DAN 5560, DAN 5560. This medicine is a orange, ...
Malnutrition, long term-Disopyramide may cause low blood sugar Proper Use. Take disopyramide exactly as directed by your doctor ... Enlarged prostate-Disopyramide may cause difficult urination * Electrolyte disorders-Disopyramide may worsen heart rhythm ... Information about this disopyramide-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have shown ... Disopyramide may cause dryness of the eyes, mouth, and nose. For temporary relief of mouth dryness, use sugarless candy or gum ...
... disopyramide phosphate) is an antiarrhythmic drug available for oral administration in immediate-release and controlled-release ... capsules containing 100 mg or 150 mg of disopyramide base, present as the phosphate. The ... ... Norpace (disopyramide phosphate) is an antiarrhythmic drug available for oral administration in immediate-release and ... Norpace CR (controlled-release) capsules are designed to afford a gradual and consistent release of disopyramide. Thus, for ...
Capsules; Oral; Disopyramide 100 mg*Tablets, Extended Release; Oral; Disopyramide 250 mg. ...
Disopyramide phosphate , C21H32N3O5P , CID 30928 - structure, chemical names, physical and chemical properties, classification ...
... disopyramide explanation free. What is disopyramide? Meaning of disopyramide medical term. What does disopyramide mean? ... Looking for online definition of disopyramide in the Medical Dictionary? ... disopyramide. Also found in: Dictionary, Wikipedia.. Related to disopyramide: lidocaine, amiodarone. disopyramide. [di″-so-pēr´ ... disopyramide. Norpace® An antiarrhythmic. disopyramide. A drug used to prevent or control disturbances of heart rhythm. Brand ...
2 Rifampicin treatment markedly increased the metabolism of disopyramide. 3 Phenytoin had effects similar to those of ... and disopyramide treatments on the metabolism of disopyramide were studied in patients and volunteers. ... 4 The metabolism of disopyramide seemed fastest in the patient group with the higher dose of disopyramide. Both in patients and ... 1 The effects of rifampicin, phenytoin, and disopyramide treatments on the metabolism of disopyramide were studied in patients ...
Isomide information about active ingredients, pharmaceutical forms and doses by Shire, Isomide indications, usages and related health products lists
Rythmodan is used to treat abnormal heart rhythms (arrhythmias). It works by decreasing the sensitivity of heart muscle cells to electrical impulses. Learn More!
To the Editors: Singh (1), in a recent review article on ventricular arrhythmias, lists as unknown the efficacy of disopyramide ... Disopyramide and Inducible Arrhythmias. Ann Intern Med. ;115:409. doi: 10.7326/0003-4819-115-5-409_1 ... Studies involving crossover drug testing have shown disopyramide to be equivalent to quinidine (3) and superior to mexiletine ( ... These investigators found that disopyramide rendered 34% of the patients noninducible. ...
Simulation of serum disopyramide concentrations during transfer from steady-state immediate-release (IR) disopyramide to a ... Transfer from Immediate-Release Disopyramide to Controlled-Release Disopyramide. DiPersio, David M.; Chow, Moses S. S. // ... and the preliminary finding of our use of controlled-release disopyramide are described. Controlled-release disopyramide is a ... prescription-only preparation of the anti-arrhythmic disopyramide (as disopyramide phosphate), and is available as capsules. ...
The National Center for Biomedical Ontology was founded as one of the National Centers for Biomedical Computing, supported by the NHGRI, the NHLBI, and the NIH Common Fund under grant U54-HG004028 ...
Disopyramide has the potential to suppress sinus node function and, therefore, must be used cautiously in patients with the ... Since disopyramide was introduced 5 years ago, the therapeutic spectrum of this drug in treating patients with ventricular and ... Disopyramide and Cholestasis Annals of Internal Medicine; 93 (1_Part_1): 150-151 ... Disopyramide has been found at times to precipitate ventricular tachycardia or ventricular fibrillation. Because this drug ...
Sprawdź ile zapłacisz za lek Disopyramide w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie ...
Disopyramide on Lux Cellulose-2. Column used: Lux® 5 µm Cellulose-2, LC Column 250 x 4.6 mm, Ea Part#: 00G-4457-E0 ...
Common side effects of Disopyramide includes dry mouth and eyes, blurred vision, constipation. If you experience any of these, ... Before taking Disopyramide, what precautions must I follow?. What food or medicine must I avoid when I take Disopyramide?. * ... Disopyramide - Side Effects, Precautions, and Contraindications. What side effects can Disopyramide cause?. Common side effects ... Disopyramide may affect the heart rhythm, namely the QT-interval which is monitored using an electrocardiogram (ECG). To reduce ...
Announces Cohort 3 of REDWOOD-HCM is Open to EnrollmentNext Cohort to Enroll Patients on Background Therapy of Disopyramide - ... "Given that disopyramide is often prescribed in patients with more severe HCM, the data from Cohort 3 may support the potential ... Cohort 3 will enroll, in an open label fashion, 8-12 patients whose background therapy includes disopyramide to assess the ... In Cohorts 1 and 2, patients continued taking background medications exclusive of disopyramide. ...
DISOPYRAMIDE (dye soe PEER a mide) is an antiarrhythmic drug. It helps make your heart beat regularly. This medicine also helps ... an unusual or allergic reaction to disopyramide, other medicines, foods, dyes, or preservatives ...
Flecainide compared with a combination of digoxin and disopyramide for acute atrial arrhythmias after cardiopulmonary bypass. ... Flecainide compared with a combination of digoxin and disopyramide for acute atrial arrhythmias after cardiopulmonary bypass. ... Flecainide compared with a combination of digoxin and disopyramide for acute atrial arrhythmias after cardiopulmonary bypass. ...
  • Disopyramide phosphate is a Type 1 antiarrhythmic drug (i.e., similar to procainamide and quinidine). (drugs.com)
  • Disopyramide shares electrophysiologic properties with quinidine and procainamide. (labcorp.com)
  • Since disopyramide was introduced 5 years ago, the therapeutic spectrum of this drug in treating patients with ventricular and atrial arrhythmias has been found to be similar to that of the other type I antiarrhythmic drugs, quinidine and procainamide. (annals.org)
  • A comparative study of disopyramide and procainamide in the treatment of myotonia in myotonic dystrophy. (bmj.com)
  • We studied the interaction of disopyramide, quinidine, and procainamide with cardiac muscarinic receptors. (ahajournals.org)
  • In electrophysiological experiments, the effects of disopyramide, quinidine, procainamide, and atropine were determined on spontaneously depolarizing guinea pig right atria (GPRA) both in the presence and absence of pharmacologically induced (physostigmine) cholinergic stimulation. (ahajournals.org)
  • The order of anticholinergic potency was atropine greater than disopyramide greater than quinidine greater than procainamide. (ahajournals.org)
  • In parallel experiments, we studied the ability of disopyramide, quinidine, procainamide, and atropine to compete with the radiolabeled muscarinic receptor antagonist [3H] quinuclidinyl benzilate ([3H]QNB) for binding to muscarinic receptors in crude homogenates of GPRA and membrane vesicles from canine ventricular myocardium. (ahajournals.org)
  • Nursing Central, nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425005/all/Antidysrhythmic_Drugs_:_Amiodarone__Digoxin__Disopyramide__Flecainide__Lidocaine__Procainamide__Quinidine. (unboundmedicine.com)
  • The order of potencies for inducing the negative chronotropic effect in isolated atrium preparations was verapamil greater than propranolol greater than lidocaine = quinidine greater than phenytoin greater than or equal to disopyramide greater than procainamide. (meta.org)
  • Class Ia agents include quinidine, procainamide and disopyramide. (wikipedia.org)
  • Norpace CR (controlled-release) capsules are designed to afford a gradual and consistent release of disopyramide. (egeneralmedical.com)
  • In a crossover study in healthy subjects, the bio-availability of disopyramide from Norpace CR capsules was similar to that from the immediate-release capsules. (pfizermedicalinformation.com)
  • With a single 300-mg oral dose, peak disopyramide plasma concentrations of 3.23 ± 0.75 mcg/ml (mean ± SD) at 2.5 ± 2.3 hours were obtained with two 150-mg immediate-release capsules and 2.22 ± 0.47 mcg/ml at 4.9 ± 1.4 hours with two 150-mg Norpace CR capsules. (pfizermedicalinformation.com)
  • The elimination half-life of disopyramide was 8.31 ± 1.83 hours with the immediate-release capsules and 11.65 ± 4.72 hours with Norpace CR capsules. (pfizermedicalinformation.com)
  • Disopyramide may increase the chance of having arrhythmias (irregular heartbeats) and has not been proven to help people without life-threatening arrhythmias to live longer. (medlineplus.gov)
  • Disopyramide helps to treat arrhythmias by decreasing the sensitivity of the heart muscle cells to electrical impulses. (netdoctor.co.uk)
  • Levites proposed a possible secondary mode of action for disopyramide, against reentrant arrhythmias after an ischemic insult. (wikipedia.org)
  • Singh (1), in a recent review article on ventricular arrhythmias, lists as unknown the efficacy of disopyramide in suppressing ventricular tachycardia and ventricular fibrillation at programmed electrical stimulation. (annals.org)
  • Long-Term Use of Controlled-Release Disopyramide in Patients with Severe Ventricular Arrhythmias. (ebscohost.com)
  • Controlled-release (CR) disopyramide phosphate has been available for the past four years for the management of patients with ventricular arrhythmias. (ebscohost.com)
  • Disopyramide phosphate, seven years after its introduction, has proved to be a useful and effective Type IA oral agent for treatment of ventricular arrhythmias. (ebscohost.com)
  • Flecainide compared with a combination of digoxin and disopyramide for acute atrial arrhythmias after cardiopulmonary bypass. (bmj.com)
  • Disopyramide is useful in treatment of life threatening ventricular arrhythmias. (lalpathlabs.com)
  • The more severe side effect of disopyramide is causing of worsening arrhythmias. (medicinehow.com)
  • For example, it is more likely that disopyramide will have a negative effect on your heart and cause arrhythmias if you have an electrolyte imbalance in your blood (e.g. hypo- or hyperkalemia, hypomagnesia). (medicinehow.com)
  • Rythmodan capsules and injection both contain the active ingredient disopyramide, which is a type of medicine called an anti-arrhythmic. (netdoctor.co.uk)
  • Rythmodan retard tablets contain the active ingredient disopyramide, which is a type of medicine called an anti-arrhythmic. (netdoctor.co.uk)
  • Rythmodan retard tablets are a 'long-acting' or 'modified-release' form of disopyramide. (netdoctor.co.uk)
  • Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication used in the treatment of ventricular tachycardia. (wikipedia.org)
  • Disopyramide capsules may be taken every 6 or 8 hours. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to disopyramide, any other medications, or any of the ingredients in disopyramide capsules. (medlineplus.gov)
  • Disopyramide capsules are also available without a brand name, ie as the generic medicine. (netdoctor.co.uk)
  • Disopyramide phosphate is an antiarrhythmic drug available for oral administration in immediate-release capsules containing 100 mg or 150 mg of Disopyramide base, present as the phosphate. (drugs.com)
  • Disopyramide phosphate capsules (equivalent to 100 mg Disopyramide Base) and Disopyramide phosphate capsules (equivalent to 150 mg Disopyramide Base) contain the following inactive ingredients: magnesium stearate, microcrystalline cellulose and sodium lauryl sulfate. (drugs.com)
  • The article presents information on isomide CR, a proprietary, prescription-only preparation of the anti-arrhythmic disopyramide (as disopyramide phosphate), and is available as capsules. (ebscohost.com)
  • When converting from IR to ER disopyramide, start maintenance schedule of ER capsules 6 h after last dose of IR. (drugster.info)
  • Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potentials. (duke.edu)
  • Disopyramide comes as a capsule and an extended-release (long-acting) capsule to take by mouth. (medlineplus.gov)
  • Severe Hypoglycemia-induced Right Hemiparesis with Reversible Diffusion Restriction in the Left Internal Capsule Due to Combination Therapy Using Disopyramide and Clarithromycin. (annals.org)
  • Disopyramide phosphate ER ( disopyramide phosphate ) capsule, extended release. (thefreedictionary.com)
  • 0591-5560 Disopyramide 100 mg (As Disopyramide Phosphate) Oral Capsule by Watson Laboratories, Inc. (medschat.com)
  • Disopyramide is available as a 100mg capsule. (singhealth.com.sg)
  • The effects of the antiarrhythmic agent disopyramide was studied on responses from voltage-clamped endplates at the neuromuscular junction of the garter snake. (strath.ac.uk)
  • Immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, urine) to measure levels of disopyramide (a class I antiarrhythmic agent [one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent] with a depressant action on the heart similar to that of guanidine) present in the sample. (ophthalmologymanagement.com)
  • Simulation of serum disopyramide concentrations during transfer from steady-state immediate-release (IR) disopyramide to a sustained-release disopyramide preparation was performed based on pharmacokinetic parameters obtained from fit disopyramide and serum concentrations measured following an. (ebscohost.com)
  • Following oral administration of immediate-release Disopyramide phosphate, Disopyramide phosphate is rapidly and almost completely absorbed, and peak plasma levels are usually attained within 2 hours. (drugs.com)
  • Transfer from Immediate-Release Disopyramide to Controlled-Release Disopyramide. (ebscohost.com)
  • Brand-name disopyramide is made by G.D. Searle, LLC, a division of Pfizer, Inc. Generic immediate-release disopyramide is made by Watson Laboratories and Teva Pharmaceuticals. (emedtv.com)
  • Disopyramide depresses the increase in sodium permeability of the cardiac myocyte during Phase 0 of the cardiac action potential, in turn decreasing the inward sodium current. (wikipedia.org)
  • In animal studies Disopyramide decreases the rate of diastolic depolarization (phase 4) in cells with augmented automaticity, decreases the upstroke velocity (phase 0) and increases the action potential duration of normal cardiac cells, decreases the disparity in refractoriness between infarcted and adjacent normally perfused myocardium, and has no effect on alpha- or beta-adrenergic receptors. (drugs.com)
  • Intravenous Disopyramide may cause cardiac depression with an approximate mean 10% reduction of cardiac output, which is more pronounced in patients with cardiac dysfunction. (drugs.com)
  • After the oral administration of 200 mg of Disopyramide to 10 cardiac patients with borderline to moderate heart failure, the time to peak serum concentration of 2.3 ± 1.5 hours (mean ± SD) was increased, and the mean peak serum concentration of 4.8 ± 1.6 mcg/mL was higher than in healthy volunteers. (drugs.com)
  • There were no cardiac events within 3 months of disopyramide initiation. (ahajournals.org)
  • Conclusions Initiation of disopyramide in the outpatient setting is safe and the risk of subsequent sudden cardiac death is low. (ahajournals.org)
  • Taking antiarrhythmic drugs, including disopyramide, may increase the risk of death. (medlineplus.gov)
  • What other drugs will affect disopyramide? (cigna.com)
  • Many drugs can interact with disopyramide. (cigna.com)
  • The pharmacology of disopyramide, potential advantages and disadvantages of the use of sustained- (or controlled-)release formulations of drugs, and the preliminary finding of our use of controlled-release disopyramide are described. (ebscohost.com)
  • Disopyramide can interact with some other drugs that you are taken and, depending on the situation, it may be best to avoid some combinations altogether. (medicinehow.com)
  • Concomitant treatment with phenytoin may lead to decreased serum levels of disopyramide. (labcorp.com)
  • 1 The effects of rifampicin, phenytoin, and disopyramide treatments on the metabolism of disopyramide were studied in patients and volunteers. (nih.gov)
  • Phenytoin can decrease the concentration of disopyramide in your body so that it doesn't work as well. (medicinehow.com)
  • 4 The metabolism of disopyramide seemed fastest in the patient group with the higher dose of disopyramide. (nih.gov)
  • In healthy men, about 50% of a given dose of disopyramide is excreted in the urine as the unchanged drug, about 20% as the mono-N-dealkylated metabolite, and 10% as the other metabolites. (pfizermedicalinformation.com)
  • The inducing effect of disopyramide remained uncertain. (nih.gov)
  • Rifampicin and decrease the concentration and effect of disopyramide. (medicinehow.com)
  • Disopyramide is in a class of medications called antiarrhythmic medications. (medlineplus.gov)
  • Older adults should not usually take disopyramide because it is not as safe or effective as other medications that can be used to treat the same condition. (medlineplus.gov)
  • In Cohorts 1 and 2, patients continued taking background medications exclusive of disopyramide. (biospace.com)
  • You are strongly advised to inform the Cardiologist/Doctor or Pharmacist that you are taking Disopyramide, so that they can ensure that your combination of medications is safe for you. (singhealth.com.sg)
  • Another concern about disopyramide has been the hypothetical potential for inducing sudden death from its type 1 anti-arrhythmic effects. (wikipedia.org)
  • Disopyramide is known as an anti-arrhythmic drug. (webmd.com)
  • The article presents information on rhythmodan retard, a proprietary, prescription-only preparation of the anti-arrhythmic disopyramide. (ebscohost.com)
  • Take disopyramide exactly as directed. (medlineplus.gov)
  • Continue to take disopyramide even if you feel well. (medlineplus.gov)
  • Your doctor may tell you not to take disopyramide. (medlineplus.gov)
  • How should I take disopyramide? (cigna.com)
  • Sudden changes in the way you take disopyramide can make your condition worse. (cigna.com)
  • Who should not take Disopyramide Phosphate? (webmd.com)
  • What food or medicine must I avoid when I take Disopyramide? (singhealth.com.sg)
  • As a result, the use of disopyramide may reduce contractile force up to 42% at low doses and up to 100% in higher doses leading to heart failure. (wikipedia.org)
  • This combination increases acceptance of higher disopyramide dosing, important since there is a dose-response correlation in obstructive HCM, higher doses yielding lower gradients. (wikipedia.org)
  • Disopyramide also has an anticholinergic effect on the heart which accounts for many adverse side effects. (wikipedia.org)
  • however, the usual dose for Disopyramide (as the phosphate) is 150 mg every 6 hours, compared to 0.4 to 0.6 mg for atropine (see WARNINGS and ADVERSE REACTIONS for anticholinergic side effects). (drugs.com)
  • Anticholinergic effects of disopyramide and quinidine on guinea pig myocardium. (ahajournals.org)
  • The data from this study localize the anticholinergic effects of disopyramide and quinidine to the muscarinic receptor. (ahajournals.org)
  • 4][5] Disopyramide also has an anticholinergic effect on th. (medschat.com)
  • Disopyramide is available in both oral and intravenous forms, and has a low degree of toxicity. (wikipedia.org)
  • In a second study of the oral administration of Disopyramide to 7 patients with heart disease, including left ventricular dysfunction, the mean plasma half-life was slightly prolonged to 7.8 ± 1.9 hours (range of 5 to 9.5 hours). (drugs.com)
  • A placebo-controlled trial of intravenous and oral disopyramide for prevention of neurally mediated syncope induced by head-up tilt. (thefreedictionary.com)
  • The pharmacokinetics of disopyramide and its effects on the electrocardiogram were studied in five healthy male volunteers after intravenous (50 mg) and oral (200 mg) administration. (elsevier.com)
  • Disopyramide is used to treat certain types of irregular heartbeats). (medlineplus.gov)
  • Disopyramide is used correct irregular heartbeats and maintain heart rhythms. (netdoctor.co.uk)
  • Disopyramide is used to treat life-threatening irregular heartbeat patterns. (cigna.com)
  • Macrolides and increase the concentration of disopyramide in your body and increase the risk of side effects such as irregular heartbeat and hypoglycemia. (medicinehow.com)
  • Both in patients and volunteers a significant increase occurred in the urinary mono-N-dealkyldisopyramide/disopyramide ratio during the first week of disopyramide therapy. (nih.gov)
  • Altering the urinary pH in man does not affect the plasma half-life of disopyramide. (pfizermedicalinformation.com)
  • Disopyramide-induced urinary retention. (nih.gov)
  • With intravenous Disopyramide, either increases in systolic/diastolic or decreases in systolic blood pressure have been reported, depending on the infusion rate and the patient population. (drugs.com)
  • Alcohol can make the side effects from disopyramide worse. (medlineplus.gov)
  • Disopyramide may cause side effects. (medlineplus.gov)
  • showed that pyridostigmine used in combination with disopyramide substantially alleviates vagolytic side effects without compromising antiarrhythmic efficacy. (wikipedia.org)
  • Drinking alcohol can increase certain side effects of disopyramide. (cigna.com)
  • What are the possible side effects of disopyramide? (cigna.com)
  • List Disopyramide Phosphate side effects by likelihood and severity. (webmd.com)
  • Some side effects, such as difficult urination and dry mouth, may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of disopyramide. (mayoclinic.org)
  • What side effects can Disopyramide cause? (singhealth.com.sg)
  • Thirty‐eight patients (23%) developed side effects of disopyramide and 18 (11%) stopped the drug because of these side effects. (ahajournals.org)
  • 2 Rifampicin treatment markedly increased the metabolism of disopyramide. (nih.gov)
  • The generic ingredient in DISOPYRAMIDE PHOSPHATE is disopyramide phosphate . (drugpatentwatch.com)
  • Disopyramide is available in brand-name and generic forms, and comes in 100-mg and 150-mg strengths. (emedtv.com)
  • Generic controlled-release disopyramide is made by Nesher Pharmaceuticals. (emedtv.com)
  • The U.S. Food and Drug Administration (FDA) has determined that all of the generic disopyramide versions currently available should be equivalent to the brand-name medication. (emedtv.com)
  • Disopyramide is the generic name, the name of the active ingredient in the medication. (medicinehow.com)
  • Disopyramide may also be used for purposes not listed in this medication guide. (cigna.com)
  • Disopyramide is an antiarrhythmic medication used in the treatment of ventricular tachycardia. (qedbio.com)
  • Studies involving crossover drug testing have shown disopyramide to be equivalent to quinidine (3) and superior to mexiletine (4) for rendering ventricular tachyarrhythmias noninducible. (annals.org)
  • Cohort 3 will enroll, in an open label fashion, 8-12 patients whose background therapy includes disopyramide to assess the safety, tolerability, pharmacokinetics, and pharmacodynamic effects of CK-274 in patients taking disopyramide. (biospace.com)
  • These values also agreed with previous reports of the pharmacokinetics of disopyramide (free base). (elsevier.com)
  • These results showed that the pharmacokinetics of disopyramide in Japanese subjects was not different from that previously reported with subjects in other countries. (elsevier.com)
  • We have evaluated the influence of several factors on the binding of disopyramide to protein in human serum using a new ultrafiltration system and the enzyme multiplied immunoassay technique (EMIT) for disopyramide immuno-assay. (ebscohost.com)
  • From a small start-up operation founded in 1990 with just three products (extended-release potassium chloride, disopyramide phosphate and nitroglycerine) and first year sales of $5 million, Ethex is expected to top the $30 million mark in sales by the end of fiscal 1995. (thefreedictionary.com)
  • When used in patients resistant to beta-blockade, disopyramide is effective in 60% of cases, reducing symptoms and gradient to the extent that invasive procedures such as surgical septal myectomy are not required. (wikipedia.org)
  • In six patients with impaired renal function (creatinine clearance less than 40 mL/min), Disopyramide half-life values were 8 to 18 hours. (drugs.com)
  • These investigators found that disopyramide rendered 34% of the patients noninducible. (annals.org)
  • Disopyramide has the potential to suppress sinus node function and, therefore, must be used cautiously in patients with the sick sinus syndrome. (annals.org)
  • Cohort 3 will enroll patients whose background therapy includes disopyramide. (biospace.com)
  • After completing enrollment in the first two cohorts in REDWOOD-HCM, we are pleased to now begin Cohort 3, which is enrolling patients who are being treated with disopyramide," said Fady I. Malik, M.D., Ph.D., Cytokinetics' Executive Vice President of Research & Development. (biospace.com)
  • Given that disopyramide is often prescribed in patients with more severe HCM, the data from Cohort 3 may support the potential use of CK-274 in a broader population of patients with obstructive HCM. (biospace.com)
  • Methods and Results All charts of patients seen in the outpatient hypertrophic cardiomyopathy clinic between 2010 and 2014 were screened for initiation of disopyramide and data were extracted. (ahajournals.org)
  • A total of 2015 patients were seen in the clinic, including 168 who were started on disopyramide. (ahajournals.org)
  • Of the patients continuing disopyramide long term, 63% remained free of septal reduction interventions at end of follow‐up. (ahajournals.org)
  • These reagents are used in tests intended to monitor disopyramide phosphate levels in patients undergoing treatment to determine the adequacy of therapy, and to diagnose drug overdose or drug-related toxicity. (ophthalmologymanagement.com)
  • Disopyramide slows the heart rate and makes the heart contract less forcefully, which helps reduce obstruction of blood flow in the heart in patients with HCM. (singhealth.com.sg)
  • More detailed information about the symptoms , causes , and treatments of Disopyramide toxicity is available below. (rightdiagnosis.com)
  • Read more about causes of Disopyramide toxicity . (rightdiagnosis.com)
  • What is Disopyramide toxicity? (rightdiagnosis.com)
  • Disopyramide is administered both orally and intravenously and has a low degree of toxicity. (qedbio.com)
  • This change can partly be due to pharmacokinetic differences between disopyramide and its metabolite. (nih.gov)
  • The Pharmacokinetic and Pharmacodynamic Effects of Varying the Free Fraction of Disopyramide. (ebscohost.com)
  • Disopyramide administration for obstructive HCM has a IIa recommendation in the 2011 American Heart Association/American College of Cardiology Foundation guidelines for treatment of obstructive HCM. (wikipedia.org)
  • You should not use disopyramide if you have long QT syndrome, or a serious heart condition such as "AV block" (unless you have a pacemaker). (cigna.com)
  • Do not use disopyramide to treat any heart rhythm disorder that has not been checked and diagnosed by your doctor. (cigna.com)
  • Disopyramide affects the way that your heart beats. (cigna.com)
  • Disopyramide is used to treat abnormal heart rhythms. (mayoclinic.org)
  • Although disopyramide is used commonly to control heart rate in AF for the general population, its use in older adults is contraindicated according to Beers (Molony, 2008). (thefreedictionary.com)
  • Disopyramide may affect the heart rhythm, namely the QT-interval which is monitored using an electrocardiogram (ECG). (singhealth.com.sg)
  • Indeed, for relief of resistant symptoms, the European Society of Cardiology 5 and American Heart Association/American College of cardiology 6 guidelines rate disopyramide with a class I and IIa recommendation, respectively. (ahajournals.org)
  • Disopyramide is a drug that works by affecting the conductivity of the heart muscle to control the rate and rhythm of the heart beating. (medicinehow.com)
  • Disopyramide has several effects on the heart to control the rhythm of its beating. (medicinehow.com)
  • Disopyramide is used to treat a condition called Hypertrophic Cardiomyopathy (HCM), which is thickening of the heart muscle. (singhealth.com.sg)
  • Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. (wikipedia.org)
  • Controlled-release disopyramide offers many potential advantages over the standard formulation for improved patient compliance, possible reduction of concentration-related adverse effects, and predictability of pharmacologic effect. (ebscohost.com)
  • A Review of the Effects of Disopyramide Phosphate on Left Ventricular Function and the Peripheral Circulation. (ebscohost.com)
  • Marshall, RJ & Parratt, J 1978, ' Antidysrhythmic and haemodynamic effects of disopyramide phosphate (DP) in the early stages of experimental canine myocardial infarction ', Journal of Molecular and Cellular Cardiology , vol. 10, no. (elsevier.com)
  • Disopyramide caused dose-related negative chronotropic and inotropic effects in a dose range of 30-1000 microgram when injected directly into the cannulated sinus node artery of the isolated atrium. (meta.org)
  • Metabolite N-desisopropyl disopyramide is also pharmacologically active. (labcorp.com)
  • The plasma concentration of the major metabolite is approximately one tenth that of disopyramide. (pfizermedicalinformation.com)