Two individuals derived from two FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother. Twins are either monozygotic (TWINS, MONOZYGOTIC) or dizygotic (TWINS, DIZYGOTIC).
Disorders affecting TWINS, one or both, at any age.
Two off-spring from the same PREGNANCY. They are from a single fertilized OVUM that split into two EMBRYOS. Such twins are usually genetically identical and of the same sex.
Two offspring from the same PREGNANCY. They are from two OVA, fertilized at about the same time by two SPERMATOZOA. Such twins are genetically distinct and can be of different sexes.
Methods of detecting genetic etiology in human traits. The basic premise of twin studies is that monozygotic twins, being formed by the division of a single fertilized ovum, carry identical genes, while dizygotic twins, being formed by the fertilization of two ova by two different spermatozoa, are genetically no more similar than two siblings born after separate pregnancies. (Last, J.M., A Dictionary of Epidemiology, 2d ed)
The condition of carrying TWINS simultaneously.
The condition of carrying two or more FETUSES simultaneously.
Passage of blood from one fetus to another via an arteriovenous communication or other shunt, in a monozygotic twin pregnancy. It results in anemia in one twin and polycythemia in the other. (Lee et al., Wintrobe's Clinical Hematology, 9th ed, p737-8)
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Three individuals derived from three FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother.
Selective abortion of one or more embryos or fetuses in a multiple gestation pregnancy. The usual goal is to improve the outcome for the remaining embryos or fetuses.
The external elements and conditions which surround, influence, and affect the life and development of an organism or population.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
The outermost extra-embryonic membrane surrounding the developing embryo. In REPTILES and BIRDS, it adheres to the shell and allows exchange of gases between the egg and its environment. In MAMMALS, the chorion evolves into the fetal contribution of the PLACENTA.
Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.
An infant during the first month after birth.
The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.
The combined effects of genotypes and environmental factors together on phenotypic characteristics.
The division of a ZYGOTE into two parts, each of which is capable of further development.
The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Endoscopic examination, therapy or surgery of the fetus and amniotic cavity through abdominal or uterine entry.
Four individuals derived from four FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother.
A condition of abnormally high AMNIOTIC FLUID volume, such as greater than 2,000 ml in the LAST TRIMESTER and usually diagnosed by ultrasonographic criteria (AMNIOTIC FLUID INDEX). It is associated with maternal DIABETES MELLITUS; MULTIPLE PREGNANCY; CHROMOSOMAL DISORDERS; and congenital abnormalities.
The study of the patterns of ridges of the skin of the fingers, palms, toes, and soles.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Clinical and laboratory techniques used to enhance fertility in humans and animals.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The sequence in which children are born into the family.
Nonexpendable apparatus used during surgical procedures. They are differentiated from SURGICAL INSTRUMENTS, usually hand-held and used in the immediate operative field.
The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.
Procedures that render the female sterile by interrupting the flow in the FALLOPIAN TUBE. These procedures generally are surgical, and may also use chemicals or physical means.
A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))
Surgery performed on the nervous system or its parts.
A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.
Pathological processes involving any part of the LUNG.
A subspecialty of internal medicine concerned with the study of the RESPIRATORY SYSTEM. It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree.
The determination of oxygen-hemoglobin saturation of blood either by withdrawing a sample and passing it through a classical photoelectric oximeter or by electrodes attached to some translucent part of the body like finger, earlobe, or skin fold. It includes non-invasive oxygen monitoring by pulse oximetry.
A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.
A form of cutaneous tuberculosis. It is seen predominantly in women and typically involves the NASAL MUCOSA; BUCCAL MUCOSA; and conjunctival mucosa.

Genetic influences on cervical and lumbar disc degeneration: a magnetic resonance imaging study in twins. (1/1294)

OBJECTIVE: Degenerative intervertebral disc disease is common; however, the importance of genetic factors is unknown. This study sought to determine the extent of genetic influences on disc degeneration by classic twin study methods using magnetic resonance imaging (MRI). METHODS: We compared MRI features of degenerative disc disease in the cervical and lumbar spine of 172 monozygotic and 154 dizygotic twins (mean age 51.7 and 54.4, respectively) who were unselected for back pain or disc disease. An overall score for disc degeneration was calculated as the sum of the grades for disc height, bulge, osteophytosis, and signal intensity at each level. A "severe disease" score (excluding minor grades) and an "extent of disease" score (number of levels affected) were also calculated. RESULTS: For the overall score, heritability was 74% (95% confidence interval [95% CI] 64-81%) at the lumbar spine and 73% (95% CI 64-80%) at the cervical spine. For "severe disease," heritability was 64% and 79% at the lumbar and cervical spine, respectively, and for "extent of disease," heritability was 63% and 63%, respectively. These results were adjusted for age, weight, height, smoking, occupational manual work, and exercise. Examination of individual features revealed that disc height and bulge were highly heritable at both sites, and osteophytes were heritable in the lumbar spine. CONCLUSION: These results suggest an important genetic influence on variation in intervertebral disc degeneration. However, variation in disc signal is largely influenced by environmental factors shared by twins. The use of MRI scans to determine the phenotype in family and population studies should allow a better understanding of disease mechanisms and the identification of the genes involved.  (+info)

Discordance for Cornelia de Lange syndrome in twins. (2/1294)

A male infant, the first-born of twins, with features of Cornealia de Lange syndrome is described. His normal twin was discordnat for 3 of the 14 blood loci tested. Chromosomes from the affected infant appeared normal. Though the aetiological basis for the Cornealia de Lange syndrome remains obscure, most authorities accept genetic rather than environmental causation. The present findings of discordance for Cornelia de Lange syndrome in twins support this view but do not clarify the mode of inheritance.  (+info)

Diagnosis of twin reversed arterial perfusion sequence in the first trimester by transvaginal color Doppler ultrasound. (3/1294)

A case of twin reversed arterial perfusion (TRAP) sequence was diagnosed at 12 weeks' gestation using transvaginal color Doppler ultrasound, which demonstrated the presence of retrograde perfusion in the umbilical artery of the abnormal twin. Ultrasound imaging showed a monochorionic-diamniotic twin pregnancy with an inappropriately grown second twin, the morphological evaluation of which revealed an abnormal cephalic pole with acrania, diffuse subcutaneous edema and the presence of cardiac activity in an abnormal heart with a single chamber.  (+info)

Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension. (4/1294)

Components of the renin-angiotensin system play an important role in the normal regulation of blood pressure. We carried out a comprehensive genetic linkage study of the genes involved in the renin-angiotensin cascade in Finnish hypertensive twins and their affected siblings. We found no evidence for linkage between essential hypertension and the genes coding for renin, angiotensinogen, angiotensin-converting enzyme, or kallikrein 1 in the 329 hypertensive individuals of 142 families studied. In contrast, two intragenic markers for the type 1 angiotensin II receptor (AT1) showed some evidence for linkage in the total sample. A closer examination of this gene locus was carried out using subgroups of nonobese sibpairs with early onset of hypertension and uniform geographical origin. These stratifications yielded suggestive evidence for linkage of hypertension to the genetic area containing the AT1 gene, with a maximal multipoint logarithm of the odds (LOD) score of 2.9. A genetic association study carried out in an independent series of 50 hypertensive cases and 122 normotensive controls showed an increase in the frequency of the A1166-->C allele of the AT1 gene in the hypertensive individuals. In a novel variant of model-free multipoint linkage analysis allowing linkage disequilibrium in the calculations, an LOD score of 5.13 was obtained. Sequence analyses of the entire coding region and 848 bp of promoter region in the DNA sample on 8 index samples did not reveal previously unpublished sequence variations. The data provide evidence that a common genetic variant of the AT1 gene locus influences the risk of essential hypertension in the Finnish population.  (+info)

Breast cancer risk in monozygotic and dizygotic female twins: a 20-year population-based cohort study in Finland from 1976 to 1995. (5/1294)

This population-based study investigated the occurrence of breast cancer over a 20-year period in a cohort of monozygotic (MZ) and dizygotic (DZ) twins in Finland. Altogether, 13,176 female twins of known zygosity who were living in Finland at the end of 1975 were identified from the Finnish Twin Cohort Study and followed-up for cancer through the Finnish Cancer Registry for the years 1976-1995. Standardized incidence ratios (SIRs) were calculated, based on national cancer incidence rates. The relative risk of breast cancer for MZ twins compared to DZ twins was decreased [SIR(MZ)/SIR(DZ) ratio = 0.78; 95% confidence interval (CI), 0.58-1.0]; the decreased risk for MZ twins (SIR = 0.76; 95% CI, 0.58-1.0) accounted for this result, whereas the risk for DZ twins did not differ from the general population risk (SIR = 0.98; 95% CI, 0.84-1.1). There was no risk decrease among MZ twins in other cancers related to reproductive behavior; i.e., number of children and age at first birth seem not to explain the decreased risk of breast cancer. Our results, which are in line with earlier studies on the same topic, suggest that prenatal influences or postnatal behavioral factors may protect MZ female twins from breast cancer.  (+info)

Diagnostic utility of metabolic exercise testing in a patient with cardiovascular disease. (6/1294)

Disproportionate exercise limitation in patients with cardiovascular disease is a common problem faced by clinical cardiologists and other physicians. Symptoms may be attributed to psychological factors or hypothetical pathophysiological mechanisms that are difficult to confirm clinically. This case report describes how the use of metabolic exercise testing in a 28 year old woman with morphologically and haemodynamically mild hypertrophic cardiomyopathy and severe exercise limitation led to the diagnosis of an alternative cause for the patient's symptoms, namely a primary disturbance of the mitochondrial respiratory chain probably caused by a nuclear encoded gene defect.  (+info)

Broad ligament twin pregnancy following in-vitro fertilization. (7/1294)

We report the first case of an ectopic twin pregnancy in the broad ligament following in-vitro fertilization and embryo transfer in a patient with a previous ipsilateral (left) salpingo-oophorectomy. The previous surgery was for endometriosis. We discuss the possible contribution of the embryo transfer technique, limitations of preventive measures and importance of transvaginal ultrasound in establishing the diagnosis.  (+info)

The de Lange syndrome in one of twins. (8/1294)

A pair of female monozygotic twins, one of them affected by the de Lange syndrome is described for the first time. Monozygosity was established by most of the accepted standards in use at the present time. Speculation is offered as to whether the discordance in the manifestation of the syndrome provides any clues for understanding its controversial pathogenesis. In this regard two genetic mechanisms are discussed. One is the hypothesis of a chromosomal or mitotic instability. The other possibility would be a postzygotic new mutation of a gene or large effect.  (+info)

Dogs were the first domesticated animal and, according to the archaeological evidence, have had a close relationship with humans for at least 15,000 years. Today, dogs are common pets in our society and have been linked to increased well-being and improved health outcomes in their owners. A dog in the family during childhood is associated with ownership in adult life. The underlying factors behind this association could be related to experiences or to genetic influences. We aimed to investigate the heritability of dog ownership in a large twin sample including all twins in the Swedish Twin Registry born between 1926 and 1996 and alive in 2006. Information about dog ownership was available from 2001 to 2016 from national dog registers. The final data set included 85,542 twins from 50,507 twin pairs with known zygosity, where information on both twins were available in 35,035 pairs. Structural equation modeling was performed to estimate additive genetic effects (the heritability), common/shared
Identical twins possess exactly the same set of genes. Yet as they grow older, they may begin to display subtle differences.. They may start to look different, develop different diseases or slide into different personalities. Women who are identical twins may differ in their fertility or in the age at which they reach menopause.. These discrepancies are usually attributed to ill-defined differences in environment.. But a whole new level of explanation has been opened up by a genetic survey showing that identical twins, as they grow older, differ increasingly in what is known as their epigenome. The term refers to natural chemical modifications that occur in a persons genome shortly after conception and that act on a gene like a gas pedal or a brake, marking it for higher or lower activity.. Identical twins have the same set of epigenetic marks on the genome when they are born. But differences in the epigenome emerge as the twins grow older and become greater the longer they live apart, say a ...
So, the doctor said she has never had to deliver twins with a combination of vaginal & c-section. This was music to my ears, because the recovery for that sounds pretty intense. She said if there is no medical necessity/emergency and twin A is vertex (head down), she usually tries a vag delivery. Then twin B usually is floating around in a strange position, so usually a little manipualation is needed (as in the practioner grabs the feet), and twin B is usually delivered breech. This is safe since the cervix has already dilated and delivered one baby. I asked if both babies are ever delivered vertex.. and she said it does happen if twin B rotates into that position after the first birth, but its much more common for the second to be breech. So it sounds like I will only get a C-section if I really need it.. which is good.. but the whole manipulating the baby while hes still inside scares me a little! She said all the doctors in the practice have the same philosophy too, just in case I am ...
But as it turns out, simply sharing clothes and finishing each others sentences is definitely not the extent of a close twin relationship. In fact, 31-year-old identical twins Anna and Lucy DeCinque from Perth in Western Australia, wont stop until their lives are entirely identical.. Watch as the pair discuss their unconventional lifestyle:. The twins made quite an impact on the web a few years back when they shared with the world the unusual fact that they have the same boyfriend, electrical mechanic Ben Byrne.. And perhaps even more bizarre is the fact that they have spent a whopping $240,800 on cosmetic procedures to look even more identical. Theyve had breast implants, lip fillers and their eyebrows and eyelashes done all in the name of looking exactly the same.. ...
Brigette and Paula Powers were 32-year-old identical twins in Australia when this video was recorded. They are closer than the average set of twins, and probably always will be. They are so used to talking at the same time that it doesn’t seem like they ever talk to each other, but then again, they probably don’t need to, since each already knows everything her sister knows.[] (YouTube link)Anyone who isn’t a twin would be hard put to understand what’s ...
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OBJECTIVE: To compare dietary habits between Finnish twin migrants to Sweden and their co-twins always living in Finland, and to analyse how migration influenced food consumption patterns in the migrants. SUBJECTS/METHODS: Same-sexed twin pairs born in Finland below 75 years of age, with at least one twin migrating to Sweden (n=1083 pairs). Dietary habits were assessed by a food frequency questionnaire included in a comprehensive mailed questionnaire (response rate 71%). For 76 male twin pairs, information was also collected by a dietary history interview inquiring the habitual diet during the previous year. RESULTS: Migrant twins in Sweden had a lower intake of typical Finnish foods like dark bread and berries, and an increased consumption of fresh fruit compared with co-twins living in Finland. The migrants consumed less potatoes and more rice and pasta. Sweet pastries were consumed less often by the migrants and they also tended to more often cut out visible fat of meat and on the other hand ...
In most existing surveys the follow up period is too short or the sample size insufficient to draw firm conclusions.20 21 Only one recent Swedish register study on children born from 1982 to 1995 that examined neurological sequelae in children born after assisted conception had a sufficiently large sample size (2060 IVF twins). In this study, IVF twins were compared with a matched group of non-IVF twins, and IVF singletons were compared with a matched group of non-IVF singletons.7 The researchers found that IVF twins had a similar risk of neurological sequelae as their naturally conceived peers, but, in contrast to our results, they showed that the risk of neurological sequelae was higher in IVF twins than in IVF singletons. They did not, however, study the effect of ICSI. The crude prevalence of cerebral palsy per 1000 children in the Swedish study was 7.4, 6.9, and 3.8 for IVF/ICSI twins, control twins and IVF or ICSI singletons, respectively. In our study the corresponding rates were 3.2/1000 ...
Mom beats overwhelming odds to deliver 2 sets of identical twins The 36-year-old Houston native naturally gave birth at The Womans Hospital of Texas to a rare form of quadruplets: two sets of identical twins - a statistical phenomenon. The arrival of Ace and Blaine then Cash and Dylan a minute later was even more unusual because the Montalvos did not take fertility drugs or use in-vitro fertilization, which have contributed to a 76 percent increase in multiple births nationwide between 1980 and 2009, according to the Centers for Disease Control and Prevention. According to previous reports, Dr. James Grifo, director of the NYU Fertility Center, has said the odds of having two sets of identical twins at the same time are 1 in 10,000 with in-vitro and much rarer with natural conception. On Monday, Manuel, 43, pushed his wifes wheelchair into the neonatal intensive care unit at the Houston hospital, their 2-year-old son Memphis holding Mickey Mouse as he sat on his mothers lap. With no serious
The relationship between twins is both a bond and a rivalry that begins in the womb and lasts until they die. For the one in three sets of twins who are identical, the closeness can lead to uncanny skills at communicating with each other. During infancy and toddlerhood, they may even develop their own language. To the parents who raise them, twins bring a special set of frustrations, challenges and rewards. And one of the frustrations is that the ways parents have been advised to raise twins have shifted dramatically in recent decades. ``Until the 1970s, parents and professionals were comfortable treating twins as a single unit instead of as individuals,`` says Dr. Judith Landau- Stanton, an associate professor of psychiatry and family medicine at the University of Rochester, and the mother of 20-year-old identical twins.
Fun Fact: Did you know Pedro from the 2004 hit Napoleon Dynamite has a twin brother?Not So Fun Fact: Pedro threatened to sue his twin brother for…
Determining if same-sex twins are identical or non-identical (from one egg or two; monozygotic or dizygotic) is not always straight forward, say the researchers. They looked at data from the Gemini study, a birth cohort of 2402 families with twins born in England and Wales in 2007.. Parents of same sex twins (1586) were asked if they knew whether their twins were identical or not and how they discovered that information.. The majority of parents (1302/82%) reported that they had been given the information by health professionals based on the formation of the placenta as seen on the prenatal scan. Of this group, as part of the Gemini data collection, all parents completed a validated zygosity questionnaire[i] when their twins were on average 8.2 months old. This questionnaire asks about the childrens height, eye colour, hair colour and overall confusability and has been found in a previous study to correctly assign zygosity in 95% of cases.. The researchers found that out of the 1302 parents, ...
DEAR ABBY: I am the single mother of identical twin boys. They insist on dressing alike and use their own secret language. I have always had trouble
In fact with about 35-45 twins per live birth, this village in North Kerala, India, has four times more twins than normal. Not surprisingly, the village has been dubbed the twin village.. There seems to be a statistical error in this article. It says that in this one village there are 35-45 twins per live birth but that seems way out of line (how can you even have more than two twins per live birth). Perhaps its per 1,000 live births or something else?. J.T.D.. That makes it sound like for every live birth, 70-90 babies are popping out of a single women.. Keri. This is a real corker garnered from this mornings Yahoo News. Makes me glad Im post-menopausal. Phew!. Liz. Yes, we did mean per 1,000 live births. Many readers reacted to this one. We corrected it: GBU Editor.. Seven-year-old Fathima Lubna (L) and her twin sister Fathima Lubaba (R) carry their five-month-old sisters, who are also twins, at their residence in Kodinji village in the southern Indian city of Kerala July 28, 2009. ...
If you or someone you know is expecting twins, you may have a lot of questions. Twins are becoming more common, accounting for about 3.3...
Background Atopic traits often co-occur and this can potentially be caused by common aetiological relationships between traits, i.e. a common genetic or a common environmental background.. Objective To estimate to what extent the same genetic and environmental factors influence wheeze, rhinitis, airway hyper-responsiveness (AHR), and positive skin prick test (posSPT) in a sample of adult twins.. Methods Within a sampling frame of 21 162 twin subjects, 20-49 years of age, from the Danish Twin Registry, a total of 575 subjects (256 intact pairs and 63 single twins), who either themselves and/or their co-twins reported a history of asthma at a nationwide questionnaire survey, were clinically examined. Symptoms of wheeze and rhinitis were obtained by interview; airway responsiveness and skin test reactivity were measured using standard techniques. Correlations in liability between the different traits were estimated and latent factor models of genetic and environmental effects were fitted to the ...
There have also been many twin studies of ADHD from Europe, the United States and Australia. There are two types of twins. Identical twins are genetic copies of one another. They share 100 percent of their genes. Fraternal twins are like regular brothers and sisters. They only share 50 percent of their genes.. All of the twin studies show that if one twin has ADHD, the probability that the other twin has ADHD is much greater if the twins are identical. This is very strong evidence that genes are involved in causing ADHD.. Very recently, I worked with an international group of over 100 scientists and clinicians to study the genetic material (DNA) of 20,183 people diagnosed with ADHD and 35,191 not diagnosed with ADHD. When we compared these two groups, we found convincing evidence that 12 areas of the human genome harbored risk genes for ADHD. These data also proved that there were many more risk genes to discover. The total number is unknown but it could be in the thousands. The data also showed ...
Abstract Context:The incidence of type 1 diabetes has been increasing over time.Objective:We estimated the genetic and environmental components of type 1 diabetes susceptibility in a twin cohort of recent-onset cases to explore the sources of changing disease epidemiology.Design:We linked the population-based Italian Twin Registry with 14803 type 1 diabetes records from 36 pediatric diabetes care centers throughout Italy, except Sardinia, and identified 173 diabetic twins. Patients were positive for at least one autoantibody to islet cell, glutamate decarboxylase, tyrosine phosphatase, insulin, or zinc transporter 8 and were insulin dependent since their diagnosis. Zygosity was determined by DNA genotyping or by questionnaire.Outcome Measures:We estimated proband-wise concordance, cotwin recurrence risk with Kaplan-Meier method, and genetic and environmental proportions of susceptibility variance by structural equation models.Results:We recruited 104 diabetic twins (53 males) from 88 pairs (34 ...
Minnesota Twins single game tickets are available at Game highlights, ticket offers, promotions and more. Get your Twins tickets today!
Minnesota Twins single game tickets are available at Game highlights, ticket offers, promotions and more. Get your Twins tickets today!
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This offseason, the Minnesota Twins are going to have a rebuilding project on their hands. If they handle it correctly, the team can be back in contention within a few years...
I think it is also worth saying that the obesity-destined twin was noted, by all and sundry, to be overeating, eating badly and eating irregularly from an early age, with a preference for fatty foods. However I would comment that they did not even begin to become obese until 18 years of age and by 25 years of age doubly labelled water showed... etc etc etc. This moral failing as youngsters might just be translated as the pre-obese half of the pair were HUNGRY at that time. Life is hard when the world views your moral failings at the snack bar as evidence of your lack of will power. Being hungry is no fun. Being hungry because your adipocytes are not fat enough (yet) to ignore your hyperinsulinaemia and let you, grudgingly, have a few FFA molecules from their hoard is somewhat unfair. Your skinny twin is not hungry. He has mitochondrial ATP to spare. He sniggers at your third helping of pizza at your 18th birthday party because he has no gnawing hunger. He knows that you lie about how much you ...
Join and connect with BlackPlanets Identical Twins group. Twins Worlds largest free African-American online community where Black women and Black men meet to chat, discuss and engage on what matters to
In the comments below, John Howard asks in relation to me releasing my genotype into the public domain: Im curious if this means you give permission to be cloned, or for someone to reproduce with you, by making gametes from your genome. Do you think other people have the right to do that? Ill be honest that I laughed when I first saw this comment. My genome is not magical. If someone wants to make more of me (and I can see why theyd want to do that), I probably wouldnt mind. My siblings are versions of me diluted by a factor of 1/2, if you want to think in terms of blending analogies. But the biggest issue is this: identical twins already share very concordant genomes, and no one would presume that one twin should have a right to a say in the use of the genome of the other twin. Then again, John Howard runs a website, Dedicated to stopping genetic engineering of human beings, and preserving individual conception rights for all people. All people should be created equal, ...
To conclude, I would be interested in hearing what you have to say to my conjoined twins scenario. A single embryo at some point splits, but not completely enough to have it become a separate organism (or at least, not permanently). It then develops into identical twins who are (say) conjoined at the hips (they share the same pair of legs). If our only moral ingredients are biological, then this is only one human being. From my perspective however, since personhood depends on relevant neural structure, I would say we have two human beings (in the moral sense--one in the biological sense) since there are two brains. So as I understand your perspective, destroying said twins before birth and cell splitting would be one murder, and destroying said twins after birth would be two murders (but why two if your only criterion is biologically human genetic code ...
By 121 News. Amritsar 09th August:- Celebrating the unique connection shared by identical twins from across the country, Zee TVs recently launched non-fiction show Indias Best Judwaah has grabbed audience eyeballs right since its premiere on 22nd July. Exploring the twins world of uncanny similarities and delightful surprises for the first time on Indian television, Zee TV pioneers yet another homegrown non-fiction format. So, are twins stark opposites of each other in every other way barring their resemblance or do they mirror each other in the way they think, move, and process and behave? Come find out as Indias Best Judwaah Special Partner Finolex Cables airs every Saturday-Sunday at 8 PM. The show separates these inseparable judwaahs for the first time in their lives into two different houses and through a slew of physical and mental challenges, check how truly connected they are with their twins - Kitne Jude, Kitne Judaa! After extensive online auditions and a comprehensive ...
Carl Pavano will turn 37 in January, and he knows that, eventually, his body will betray him. It happens to every athlete. But the Twins right-hander said Friday, Sept. 7, hes confident that hasnt happened yet and that he will pitch in 2013.. Whether its with the Twins, who acquired him in a lopsided waiver-wire deal in August 2009, is a question for another time. I dont want to go out this way, I know that, he said. Pavano is out for the season because of a bruise in the part of his humerus bone that attaches to the shoulder joint. The injury was diagnosed by specialist Dr. David Altchek on Aug. 21, ending a long, thankless rehab assignment at the Twins facility in Fort Myers, Fla., where Pavano was trying to pitch through discomfort and weakness in the shoulder initially diagnosed as inflammation in the anterior shoulder capsule. He returned to the Twin Cities this week to spend time with the team he helped to win a Central Division title in 2010, when he led the staff with a 17-11 ...
Conjoined twins were born with one of them having no proper heart or lungs. One of the twins was being kept alive by the other twin whose heart circulated blood for both of them. The Doctors wanted to operate to separate the twins. This would result in the weaker twin dying. The parents would not consent to this. The Doctors claimed that it was lawful to operate. The Court of Appeal gave the declaration. In the judgement, one of the points considered was the doctrine of necessity. ...
Journal: Brain Pathology. Twins who died after suffering from dementia and Alzheimers disease had similar areas of damage to their brains, a project by researchers in California and Sweden concluded.. The scientists studied the brains of seven pairs of twins who died after years of diagnostic tests - among them the brains of identical twins who died at age 98 after being diagnosed with Alzheimers. The results support previous findings that genetics may determine how vulnerable someone is to Alzheimers and other conditions, said University of Southern California psychologist Margaret Gatz, who led the study.. We looked not just at the hallmark indicators of Alzheimers, but at all the other damage in the brain. Across the whole array of neuropathological changes, the identical twins appeared to have more similar pathologies, Gatz said in announcing the findings. This is fascinating. Its not just a key pathology related to the twins diagnoses but the combination of things happening in ...
To the Editor: As a twin, and as the father of twins, I feel qualified to weigh in. When I was a toddler, my twin sister ruled the roost. When my mother served dinner, I would turn to my twin to ask her if I liked the dish. If my twin said no, I wouldnt eat it.
The terms Siamese Twins and Conjoined Twins are synonymous, 1 The term Siamese twins comes from the most famous of conjoined male twins, Chang and Eng Bunker, born in Siam of Chinese parents in The Bunker Twins were exhibited in Barnums circus for many years.4/4(1).
A lot of people say, Wow, youre a single father of twin boys, thats crazy! Two toddlers can get hectic, but I wouldnt change it for anything. Every day they teach me different things. The love is there. When you have a two-year-old saying every... - Ricky Martin quotes from
Twin birthrate - the twinning rate - in the U.S. in 2010, according to the CDC: 33.1 per 1,000 live births - or about 1 out of 30.. Twinning rate in 1980, according to the CDC: 1 per 53.. Triplet or higher-order birthrate in the U.S. in 2010: 137.6 per 100,000 live births - or about 1 out of 728.. Odds of winning $7 in Powerball by matching two white balls and the red ball: about 1 in 706.. Matching three white balls and the red ball for $100: about 1 in 12,245.. Powerballs Grand Prize: 1 in 175,223,510.. Total number of quintuplet and other higher-order births in the U.S. in 2010: 37.. Rate of Minnesota Twins World Series victories: 1 per 54 seasons played.. Snap judgment: You might be better off wagering that the Minnesota Twins will win the series in any given year - or that a pregnant friend will have triplets - than hoping for great returns in Powerball. ...
Its still MaxFunDrive time! Become a member today and support the production of Judge John Hodgman every week. This show could not exist without your support!. Dont forget to tune into our end-of-pledge-drive MaxFun Extravaganza on Friday March 31! Starting at 7pm Pacific/10pm Eastern, well be livestreaming a fun show full of MaxFun hosts and pals. Visit the Maximum Fun website to check it out!. Plus Judge Hodgman is still doing his Instagram shoutouts to donors at the leadership level - hear more about it on this episode. Xander brings the case against his twin brother, Brendan. They dont know for certain if they are fraternal or identical twins. Xander wants to take a zygosity test to find the answer. But, Brendan is opposed! Whos right? Whos wrong?. EVIDENCE ...
Twins Family friends are expecting twins. While they are, of course, excited, they also are looking for advice on parenting two new daughters. As a parent of twins, they asked me some any words of wisdom. As I wrote my recommendations in a letter to the mom and dad, I thought that this advice may be relevant to other parents or grandparents of twins. Also, it can certainly be modified to use with children that are not born five minutes apart. Here it is:Dear Friends,I am glad you are looking forward to the adventure of twins. I wish I could give you advice that would help for every scenario you might face. Unfortunately, there will be times when you have to, as my Grandmother used to say, Just fly by the seat of your pants . However, I do have some routines that worked well for my family.When you go to pick up a baby, do not go to the same crib first each time. It may not sound important, but it helps you not to have one child be the one who always gets your attention first. In that same lines of
A veteran veterinarian delivered the first known biologically identical puppy twins in South Africa, researchers who tested the pups DNA over several weeks confirm. Kurt de Cramer, who works in South Africas...
Genetics of Diabetes. Youve probably wondered how you developed diabetes. You may worry that your children will develop it too.. Unlike some traits, diabetes does not seem to be inherited in a simple pattern. Yet clearly, some people are born more likely to develop diabetes than others.. What Leads to Diabetes?. Type 1 and type 2 diabetes have different causes. Yet two factors are important in both. You inherit a predisposition to the disease then something in your environment triggers it.. Genes alone are not enough. One proof of this is identical twins. Identical twins have identical genes. Yet when one twin has type 1 diabetes, the other gets the disease at most only half the time.. When one twin has type 2 diabetes, the others risk is at most 3 in 4.. Type 1 Diabetes. In most cases of type 1 diabetes, people need to inherit risk factors from both parents. We think these factors must be more common in whites because whites have the highest rate of type 1 diabetes.. Because most people who ...
Genetics of Diabetes. Youve probably wondered how you developed diabetes. You may worry that your children will develop it too.. Unlike some traits, diabetes does not seem to be inherited in a simple pattern. Yet clearly, some people are born more likely to develop diabetes than others.. What Leads to Diabetes?. Type 1 and type 2 diabetes have different causes. Yet two factors are important in both. You inherit a predisposition to the disease then something in your environment triggers it.. Genes alone are not enough. One proof of this is identical twins. Identical twins have identical genes. Yet when one twin has type 1 diabetes, the other gets the disease at most only half the time.. When one twin has type 2 diabetes, the others risk is at most 3 in 4.. Type 1 Diabetes. In most cases of type 1 diabetes, people need to inherit risk factors from both parents. We think these factors must be more common in whites because whites have the highest rate of type 1 diabetes.. Because most people who ...
Parisian twins Monette and Mady have spent their lives embracing their shared appearance, dressing exactly alike every day of their adulthood. The results are unsettling, to say the least.
They are the face of the Russian army - the 154th commandant regiment has witnessed many historic events. Getting through the selection process is anything but simple, but if you are a twin you are in.
Twins Jordan and Justin McCray, who helped UCF win the 2014 Fiesta Bowl against Baylor, have signed with the Orlando Predators of the Arena Football League.
Six-year-old Corey Ricci is like most other kids: loves his footy, loves his mates and his identical twin brother, with whom he has one big difference. One of Coreys legs is shorter than the other. His dad Aldo says: Now that hes getting a little bit older, he cant get around as well as the kids that he goes to school with.. My friend Blake is too fast for me (but) when I get angry, I get faster, says Corey. It happened as the result of an infection, days after Corey and his twin brother Dylan were born.. We did know he was sick, but just as far as the long-term consequences and what the outcome was going to be, we really had no idea, says Coreys mum Kylie.. Coreys parents were faced with the difficult situation of having their newborn twin sons in separate hospitals.. It was pretty hard, says Kylie. Pretty heart-wrenching, but then Ashford moved Dylan up to Flinders so we could all be at the same place at the same time.. As time went by, and the twins grew, the difference between ...
A 9-year-old girl with a rare genetic disease was fortunate to receive a life-saving bone marrow donation from her own twin brother. ...
Another day, another baby turned internet star. This time, its a confused baby girl who meets her fathers twin brother for the very first time. While its true that identical twins arent 100% similar, but the reaction youre about to see is most certainly internet-worthy. Continue reading for more.. ...
Melbourne identical twins Raie Moss and Judy Kohn are sharing their breast cancer journey to encourage other twins to join a major new Australian study aiming to identify factors in early life that may predict risk of breast cancer.
When an identical twin receives a cancer diagnosis, it somewhat raises the other twins chance of developing not only that form of cancer, but any form at all of the disease.
This time around, we are having identical twins. Starting from the time I told my family that it was twins, it is a constant bombardment of questions about gender, how soon we can find out, demanding that we must find out this time. DH is not completely decided about needing to know the gender but he is leaning towards wanting to know purely so that we dont have to discuss and decide on names for the other gender. Personally, I still dont want to know. I see a MFM high risk specialist next week for a high level ultrasound and most likely, if I really wanted to know, they could tell me with pretty good certainty what the genders are then. I also have the anatomy scan at 20 weeks, which is a little over a month after that. And most likely, I will have atleast a dozen more scans before the end of my pregnancy because of the babies being mono/di twins ...
BRADENTON, Fla. -- Twins general manager Terry Ryan and manager Ron Gardenhire had nothing but positive things to say about former Minnesota left-hander Francisco Liriano, who signed with the Pirates as a free agent this offseason.. Ryan said the Twins had discussions with Lirianos agent this offseason to bring back the lefty after he was traded to the White Sox in July for left-hander Pedro Hernandez and infielder Eduardo Escobar.. Liriano said that the Twins discussed a two-year contract but Pittsburgh offered him a better deal. Liriano originally agreed to a two-year deal worth $12.75 million with the Pirates but it was later amended because he broke his right arm by accidentally slamming it in a door while playing around with his children on Christmas. Liriano, who has yet to pitch this spring, is guaranteed only $1 million this season with incentives in place to reach his original deal.. I wanted to go to the National League, said Liriano, who hopes to return to action by mid-to-late ...
Since RNA viruses have been shown to cause leukemia in mice, rats, cats, and birds, intensive studies have attempted to link similar viruses with human leukemia. In the absence of a demonstrable human leukemia virus, immunological attempts to detect viral antigens have been hampered by lack of suitable controls. This study of identical twins, one with leukemia and one clinically normal, provided an excellent opportunity to use a variety of test procedures to detect an antigen in the leukemic patient, possibly tumor-specific, that would not be present in the identical twin. Four sets of identical twins, all children with acute ...
Monozygotic twins are genetically nearly identical and they are always the same sex unless there has been a mutation during development. The children of monozygotic twins test genetically as half-siblings (or full siblings, if a pair of monozygotic twins reproduces with another pair or with the same person), rather than first cousins. Identical twins do not have the same fingerprints however, because even within the confines of the womb, the fetuses touch different parts of their environment, giving rise to small variations in their corresponding prints and thus making them unique.[28]. Monozygotic twins always have the same phenotype. Normally due to an environmental factor or the deactivation of different X chromosomes in female monozygotic twins, and in some extremely rare cases, due to aneuploidy, twins may express different sexual phenotypes, normally from an XXY Klinefelter syndrome zygote splitting unevenly.[29][30][31]. Monozygotic twins, although genetically very similar, are not ...
Following widespread application of assisted reproductive technology modalities and the increased age of motherhood, the incidence of twin gestations has increased markedly. Twins are either monozygotic or dizygotic. Dizygotic (i.e. fraternal) twins result from the fertilization of two different eggs and are per definition dichorionic (DC). Chorionicity of monozygotic twins ... read more (i.e. identical twins) depends on timing of splitting of the fertilized egg. If splitting occurs within three days after fertilization, the monozygotic twin will be DC. Splitting after the third day results in monochorionic (MC) twinning. Twins have an increased risk of perinatal mortality and neonatal morbidity compared to singletons. MC twin pregnancies, which occur in about 1 of 400 pregnancies, carry a higher risk of perinatal complications compared to DC twins. This is mainly attributed to the unique architecture of the MC placenta. The aim of this thesis was to study perinatal mortality and (long-term) ...
The sometimes-preternatural similarity of identical twins is more profound than previously thought. Identical twins, known to science as monozygotic, may share more than identical looks and genes, according to new research in the field of epigenetics … ...
Although clones start off identical, they may not stay that way. Identical twins always have slightly different phenotypes.[2][3]. Although monozygotic twins are genetically almost identical, a 2012 study of 92 pairs of monozygotic twins found that monozygotic twins acquire several hundred genetic differences early in foetal development. This is caused by mutations (or copy errors) taking place in the DNA of each twin after the splitting of the embryo.[4] It is estimated that, on average, a set of monozygotic twins will have about 360 genetic differences that occurred early in foetal development. However, these changes may have little practical effect. In practice, identical twins look and act in a very similar way. Another cause of difference between monozygotic twins is epigenetic modification. These are caused by differing environmental influences throughout their lives, which affects which genes are switched on or off. A study of 80 pairs of monozygotic twins ranging in age from three to 74 ...
Although clones start off identical, they may not stay that way. Identical twins always have slightly different phenotypes.[2][3] Although monozygotic twins are genetically almost identical, a 2012 study of 92 pairs of monozygotic twins found that monozygotic twins acquire several hundred genetic differences early in foetal development. This is caused by mutations (or copy errors) taking place in the DNA of each twin after the splitting of the embryo.[4] It is estimated that, on average, a set of monozygotic twins will have about 360 genetic differences that occurred early in foetal development. However, these changes may have little practical effect. In practice, identical twins look and act in a very similar way. Another cause of difference between monozygotic twins is epigenetic modification. These are caused by differing environmental influences throughout their lives, which affects which genes are switched on or off. A study of 80 pairs of monozygotic twins ranging in age from three to 74 ...
Results We conservatively characterised 23 de novo SNVs shared by the twin pair, 8 de novo SNVs specific to twin I and 1 de novo SNV specific to twin II. Based on the number of de novo SNVs validated by Sanger sequencing and the number of callable bases of each twin, we calculated the overall de novo SNV rate of 1.31×10−8 and 1.01×10−8 for twin I and twin II, respectively. Of these, rates of the early postzygotic de novo SNVs were estimated to be 0.34×10−8 for twin I and 0.04×10−8 for twin II.. ...
Know some twins, or expecting to? This twinspired collection pairs poems and pictures in a lighthearted salute to the many twins among us. Old twins, new twins, famous twins, not-at-all-alike twins, side-byside twins, lets play twins, not-yet twins, mirror twins - all kinds of twins! - come together in a collection of original poems by two of our most celebrated authors for young people: J. Patrick Lewis and Jane Yolen. From a wave and a wink to a twin switcheroo, from a rocket to the moon to the old woman who lived in a shoe, these poems and mini facts, whimsically illustrated by Sophie Blackall, will leave even singletons with a twinkle in their eyes. Here is the perfect book to share with the twins in your life - and everyone who loves them.
This study will evaluate the safety of giving lymphocytes (white blood cells) containing a new gene to HIV-infected individuals and will determine how long the cells survive in the bloodstream. Although the genetically altered cells will not directly benefit participants, knowledge about the safety, side effects and survival of these gene-marked cells in HIV-infected patients may lead to new treatment strategies.. Identical twin pairs 18 years of age and older-one infected with HIV, the other non-infected-may be eligible for this study. Candidates will be screened with a medical history, physical examination and blood tests.. All participants will have a tetanus booster shot. Non-infected twins will undergo a procedure called apheresis to collect white blood cells. For this procedure, whole blood is collected through a needle in an arm vein, similar to donating blood. The blood is separated it into its components by centrifugation (spinning), the white cells are removed, and the rest of the ...
Objective To determine the risk of perinatal death among twins born at term in relation to mode of delivery. Design Retrospective cohort study. Setting Scotland 1985-2001. Population All twin births at or after 36 weeks of gestation, excluding antepartum stillbirths and perinatal deaths due to congenital abnormality (n= 8073). Methods The outcome of first and second twins was compared using McNemars test and the outcome of twin pairs in relation to mode of delivery was compared using exact logistic regression. Main outcome measures Intrapartum stillbirth or neonatal death of either twin. Results Overall, there were six deaths of first twins and 30 deaths of second twins (OR for second twin 5.00, 95% CI 2.00-14.70). The odds ratio for death of the second twin due to intrapartum anoxia was 21 (95% CI 3.4-868.5). The associations were similar for twins delivered following induction of labour and for sex discordant twins. However, there was no association between birth order and the risk of death ...
Monozygotic or identical twins are the only people in the world who have the same genotype. Twins embryos are formed from a single zygote that is divided i...
The results of a twin zygosity test may be used to satisfy personal curiosity as well as to help solve future health problems. For example, in the event that a twin needs an organ or tissue transplant donor, the identical twin is a perfect choice. There are also cases in which medical records regarding zygosity have been lost, or doubt may have arisen because of the twins physical characteristics as they grow up.. In such cases only a DNA test will be able to reveal the truth. A twin zygosity test compares the twins DNA profiles to see whether they match. An exact match proves that the twins are identical.. ...
MINNEAPOLIS-ST. PAUL, Minn. - The Minnesota Twins Community Fund announced today the creation of Hope Week in 2011. Hope Week will take place from June 12 to 18 and is an entire week dedicated to giving back to the community, as well as volunteer efforts led by Twins players. Hope Week will begin with Justin Morneaus annual Casino Night public fundraiser for Juvenile Rheumatoid Arthritis on June 12. During each of the remaining days of the week, different Twins players will lead groups of teammates to participate in a number of preselected volunteer activities at various locations, agencies, and organizations. The activities will be a surprise to the recipients. Also during the week, Joe and Lisa Nathan, along with the Minnesota Twins Wives Organization, will host their annual Hang with the Majors public event to raise funds for military families.. The week will culminate on Saturday, June 18 with an on-field event where deserving youth from Twins Territory will have a chance to meet the entire ...
MINNEAPOLIS-ST. PAUL, Minn. - Target Corporation (NYSE:TGT) and the Minnesota Twins, in conjunction with the Minnesota Ballpark Authority (MBA), today unveiled plans for the construction of Target Plaza - a pedestrian bridge and public gathering space connecting Target Field to the heart of downtown Minneapolis. The bridge spanning more than two acres between 6th and 7th Streets in the Minneapolis Warehouse District will become Target Plaza located on the east side of Target Field - the new world-class home of the Twins scheduled to open in 2010. The plaza will serve as the ballparks gateway from downtown Minneapolis. As announced in September of 2008, the Twins-Target partnership calls for both companies to contribute incremental funds to enhance the overall design of Target Plaza. In addition, the Twins are working with the MBA - the public owner of Target Field and Target Plaza - to ensure the extension of the plaza pedestrian bridge along 6th Street to 1st Avenue. The Minnesota Twins are ...
North Twin (Peak) is one of the two peaks that comprise The Twins massif located at the northeast corner of the Columbia Icefield in Jasper National Park, Alberta, Canada. The other lower peak is named South Twin (3,566 m). North Twin is the third-highest peak in the Canadian Rockies, after Mount Robson and Mount Columbia. The massif was named The Twins in 1898 by J. Norman Collie and Hugh M. Stutfield. The decision to name the peaks separately was approved February 28, 1980. In addition to North Twin and South Twin, the massif contains a northern subpeak of North Twin known as Twins Tower, 3,627 m (11,900 ft). This sits atop the famed north face of the massif (see below), and was named in 1984. The first ascent of North Twin was recorded on 10 July 1923 by W.S. Ladd, J.M. Thorington, and Conrad Kain, via the East Face. The normal route is a ski mountaineering climb on the eastern slopes, and it is possible to ski all the way to the summit. A traverse can be made to the South Twin, although an ...
TWIN studies have been broadly used as a tool to investigate heritability for decades. A recent comprehensive meta-analysis reported 17,804 heritability estimates for various traits based on twin studies (Polderman et al. 2015). Estimation methods and software such as structural equation modeling (SEM) based on the classical twin models consisting of additive genetic, common, and unshared environmental effects have been well established and extensively adopted (Rijsdijk and Sham 2002). Extensions for longitudinal data or time-to-event phenotypes based on the classical twin models have been proposed (Boomsma et al. 1989; Pitkäniemi et al. 2007). Nevertheless, one of the major issues posing potential challenge is that many twin data sets contain individuals across a wide range of age and the variances of genetic and environmental components for many complex traits such as body mass index (BMI) and height change over age (Lajunen et al. 2009; Elks et al. 2012) or birth cohorts (Silventoinen et al. ...
TY - JOUR. T1 - A twin registry study of the relationship between posttraumatic stress disorder and nicotine dependence in men. AU - Koenen, Karestan C.. AU - Hitsman, Brian. AU - Lyons, Michael J.. AU - Niaura, Raymond. AU - McCaffery, Jeanne. AU - Goldberg, Jack. AU - Eisen, Seth A.. AU - True, William. AU - Tsuang, Ming. PY - 2005/11. Y1 - 2005/11. N2 - Context: Recent studies indicate a strong association between posttraumatic stress disorder (PTSD) and nicotine dependence (ND). However, the explanation for the association remains unclear. Objective: To test competing explanations for the association between PTSD and ND. Design, Setting, and Participants: Analysis of data on 6744 members of the Vietnam Era Twin Registry, a national registry of all male-male twin pairs who served in the military during the Vietnam era interviewed in 1991-1992. Main Outcome Measures: Risk of PTSD and ND using the Diagnostic Interview Schedule for the DSM-III-R. Results: The prevalence of ND was elevated among ...
Green senior football standouts Zach Wieland and Seth Wieland are identical twin brothers, yet they have different birthdays after being born 30 minutes apart. Zach was born at 11:59 p.m. July 26, 1994, and Seth was born at 12:29 a.m. on July 27, 1994.
Julie de Waroquiers photo series entitled Chimeras features sets of identical twins side-by-side in ethereal settings. The photographer from Lyon tracked down subjects through social media and word-of-mouth. She also attended the annual twins festival in the town of Pleucadeuc in Brittany.
A pair of monozygotic twin girls with coeliac disease is reported. The diagnosis was made on clinical and biochemical evidence of malabsorption, characteristic histological findings, and clinical, biochemical, and histological response to gluten elimination. Monozygosity was established on finding a single placenta at birth, exact similarity of physical appearance, similar blood group, and histocompatibility antigens, and negative reaction in mixed lymphocyte culture. This is one of six well documented cases of coeliac disease in monozygotic twins and may throw light on the importance of genetic and environmental factors in the causation and expression of the disease.. ...
TY - JOUR. T1 - Single fetal demise in a twin gestation. T2 - Umbilical vein thrombosis. AU - Baxi, Laxmi V.. AU - Daftary, Aditya. AU - Loucopoulos, Andrew. PY - 1998. Y1 - 1998. N2 - Background: Single fetal demise in a twin pregnancy is a rare event, the common causes being twin-twin transfusion syndrome, chromosomal or congenital anomalies and abnormalities of the umbilical cord and placenta. Umbilical vein thrombosis is a very rare cause of single fetal demise in twins. Case: Three days after a reassuring biophysical profile, a 40-year-old primigravida with twin pregnancy presented at 38 weeks gestation in early labor when demise of 1 of the twins was recognized. She underwent a cesarean section for arrest of labor, delivering twin A, a stillborn female weighing 2360 g and twin B, a liveborn male weighing 2200 g. Umbilical vein thrombus was noted in twin A. Conclusion: Umbilical vein thrombosis is a rare and sudden cause of fetal demise.. AB - Background: Single fetal demise in a twin ...
While for some it is the one child that parents want to revolve their lives around and put in their heart and soul bringing them up, there are others who desire the rarer twins, so that they have their hands full all the time and bring up two identical yet different but wonderful human beings. Though getting pregnant with twins is an event that is mostly attributed to luck, there are a few things that you may be able to do in order to actually conceive them. Whether they will be identical or fraternal cannot be assured. Here are some tips that will tell you how to get pregnant fast with twins. Take a look. Tips on Getting Pregnant with Twins. As mentioned earlier, to get pregnant with twins is nothing less of a miracle, but sometimes, knowingly or unknowingly, we are capable of making miracles happen. It is also a fact that people with a family history of twins are more likely to have twins for kids. As such, if you or your partner belong to such a family, your chances of having twins has just ...
Identical twins have to be the same sex because they both come from one egg. This means that they have identical genetic material, and therefore identical chromosomes.
The Minnesota Twins are the latest teamed rumored to be looking into free agent outfielder Jose Bautista.MLB.comreports that the Minnesota Twins have been in touch with free agent outfielder Jose Bautista.The Twins have had plenty of opportunity to see Bautista in action the last few years. In...
Dr. Phil met 16-year-old identical twins Taylor and Tricia in 2016 when they each weighed less than 80 lbs. The sisters were referred to separate treatment facilities to address their eating disorders, and as of September 2019, report having gained over 4
Reviews and evaluates psychological studies of separately raised identical twins and suggests which aspects of human experience are largely shaped by ones heredity
New mother Holli Gorveatt, of Kirkland, Wash., is pre- and post-partum with her identical twins after giving birth to one last month and expecting her next to arrive in January.
Seven pairs of young adult male identical twins completed a negative energy balance protocol during which they exercised on cycle ergometers twice a day, 9 out of 10 days, over a period of 93 days while being kept on a constant daily energy and nutrient intake. The total energy deficit caused by exe …
An international group of researchers has discovered a new phenomenon that occurs in identical twins: independent of their identical genes, they share an additional level of molecular similarity that influences their biological characteristics. The researchers propose a mechanism to explain the extra level of similarity and show that it is associated with risk of cancer in adulthood. The results appear in the journal Genome Biology.
IDENTICAL twins Anna and Lucy DeCinque - with their identical boyfriend, bed, mobile phone number, clothes, hairstyles, diet and cosmetic enhancements, are accustomed to being the identical centre of attention.
Professor Plum did it -- in the study with the lead pipe. Or was it Professor Plums identical twin? A new method could distinguish their DNA.
Genes vs. Environment. Some of the most startling and convincing data on the relative influences of genes vs. environment come from studies of identical twins who were separated at birth and reared apart. Identical twins come from a single egg that splits in two; the twins are genetically identical. Fraternal twins are produced by a double ovulation and are no more genetically alike than ordinary siblings. (Unlike fraternal twinning rates, there are no racial differences in the frequencies of identical twinning.). The crucial finding is that identical twins reared apart are more like each other in virtually every way than are fraternal twins who were reared in the same household. From these similarities it is possible to estimate how much of the variation in personality traits is caused by genes and how much by environment.. The chart at the bottom of this page shows twin-study estimates of the genetic contribution to various attitudes. These estimates almost certainly undervalue heritability ...
Did you ever wish you had access to a searchable database of twin correlations and trait heritability statistics? If not, once you see this, you will wonder why you hadnt been looking for this kind of resource. Shout out to David Myers (Hope College) for pointing me toward MaTCH. Lets take height as an example. From the first drop-down menu, select ICF/ICD10 Subch and then from the second drop-down menu, select Height (297). The number in parentheses refers to the number of studies included in the displayed data. This is the first chart that is generated. If one identical (mz = monozygotic) twin is tall, there is a very good chance the other will be as well. If one is short, there is a very good chance the other will be as well. The correlation between being a twin and height is .91. The chart also gives correlations for just male identical twins (mzm = monozygotic male) and female identical twins (mzf = monozygotic female). If one fraternal (dz = dizygotic) twin is tall, there is a smaller ...
Nordström et al report of 4046 monozygotic twins with discordant body mass indexes identified from a Swedish twin registry. The study recruitment was between 1998 and 2003 and follow up to December 2013. The primary end-point was the composite of death and myocardial infarction. The abstract follows: IMPORTANCE Observational studies have shown that obesity is…
During 1980-1994, the number of twin births in the United States increased by 42%, from 68,339 to 97,064, and the twin birth rate (i.e., the number of twin births to total live births) increased 30%, from 18.9 to 24.6 per 1000 live births. These increases are important because the risks for preterm birth, low birthweight (LBW), long-term disability, and early death are greater for twins than for singletons (1; CDC, unpublished data, 1991). To estimate state-specific rates of twin births, CDC analyzed data from the U.S. certificates of birth for 1992-1994. This report presents the findings of this analysis of these data, which indicate that state-specific rates of twin births varied substantially, and the variations reflect factors other than state-specific differences in maternal age distributions. In this analysis, twin births were defined as individual live births in twin deliveries, rather than sets of twins (e.g., a delivery resulting in one live birth and one stillbirth is reported as one ...
A twin study like this one involves analyzing data on identical twins. (Twin pairs that are not identical, and therefore do not have identical DNA, provide much less information about genetic effects). The study can give a statistical figure for the percentage of risk for some condition (Alzheimers disease in this case) that is attributable to genetics. In this case, the risk is 79% (with 95% confidence). The implication is that in only about one fifth of identical twin pairs the disease will develop in one of the twins but not the other, presumably on account of some sort of environmental influence. In fact, in only about 45% of pairs where one twin has developed the disease has it appeared in the other also -- though it may well appear if the other twin lives long enough ...
Monochorionic twins are identical twins who share one placenta. Caring for pregnancies with monochorionic twins varies depending on the condition of the babies.
Because the defect in IL-4 secretion was likely the result of multiple differences, a representative clone pair was chosen for intensive analysis with DNA microarrays that monitor the expression of ≈6,800 genes (Unigene collection; National Center for Biotechnology Information, Bethesda, MD). The DNA microarrays provide a practical and reproducible approach for large-scale study of complex differences in gene expression (11-14). Expression profiles were determined after 4 h of stimulation with anti-CD3 or control IgG. This time point was selected because it was used in a previous analysis of cytokine secretion in clones derived from monozygotic twin pairs discordant for type 1 diabetes (8). The number of genes with detectable expression either before or after stimulation was nearly identical for the IL-4 null and IL-4-secreting clones (1,523 and 1,558, respectively). As expected, the frequency of the majority of transcripts was unchanged. Interestingly, only about 2/3 of this set (988) were ...
The idea that twins develop entirely fabricated secret languages that only they use and only they can understand has long been a source of fascination for scientists and lay people alike. This is known as twin language, idioglossia or cryptophasia. In most cases, however, what the twins are speaking is not an entirely new or separate language. Its actually a matter of delayed or poor speech development in either one twin or both. Heres a possible scenario: Twin A has difficulty articulating certain sounds and thereby certain words. Although twin B is better able to articulate these sounds and words, he chooses to mimic or repeat the manner in which Twin A speaks. So, the two continue to talk this way, understanding what the other is saying but meanwhile it sounds like gibberish or some concocted language to you.. Why does this happen? There are a number of theories. For one, delayed speech in general is related to low birth weight and premature births. Statistics indicate that nearly 60 ...
For many twins, particularly identical, they are commonly seen as perfect halves to a whole - two parts to a puzzle that is only complete when theyre together. Yet twins, like any two siblings, have their own minds and their own personalities in spite of the fact that they may look similar. As a matter of fact, its these same twins need to be seen as individuals that often compels them to behave so differently from one another. How often have we heard about twins where one is shy and the other outgoing? Or where one is a left-brain logical type and the other a more creative sort? And dont get me started on the good twin/bad twin dichotomy. It doesnt exist.. Regardless of the labels that are put on them, twins are often seen as a package deal and no attempt at differentiating themselves from each other is successful as a result. For a twin child, being seen and appreciated as an individual will not only increase their confidence and abilities as they move through the difficult teenage ...
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Separated twins shed light on identity issues Though they share same DNA, the 2 women have vast differences Both women had the same delicate wrists and rounded hips, the same allergy to sulfa drugs. Identical twins offer a tantalizing window into the power of inheritance, and current twin studies continue to shake up our understanding of mental health, personality, the influence of parenting, and the meaning of identity. When I was a student, mothers were considered the cause of schizophrenia, said psychologist Thomas Bouchard, head of the Minnesota Center for Twin and Adoption Research. Schein thought that was all she would discover when, some months later, she received a certified letter from an adoption agency. Eventually a social worker connected to the adoption agency found her lost twin. The social worker explained to Schein that the pair had been separated as part of an experiment, but said that she did not know the details. Bouchard himself believes that twins reared apart could yield
Studies of twins are the prime instrument for determining the heritability of diseases and normal traits. A pair of twins growing up together are exposed to roughly the same environment but while fraternal twins are no more genetically alike than siblings in general, identical twins share all their genes. So if a disease occurs more often in both individuals of identical pairs compared with fraternal pairs, it points to the involvement of genes. Gervil and his colleagues based the new study on clinical interviews with 947 sets of adult identical and fraternal twins. At least one twin in each pair reported suffering from migraine and all the interviewees were identified via the Danish Twin Register, in which all twins born in Denmark between 1953 and 1982 are registered. It is often called the world s best twin register, and it was the access to this information combined with the great interest among Danes to participate in scientific studies that made our investigation possible, says Gervil. ...
Hi! Im Amber. I have 3 children (all born healthy with completely normal low risk pregnancies), and Im 7 weeks pregnant with twins. I spoke with my midwife today and was informed that I tested positive for E antibodies. She said my level was only 1, which Im assuming she meant 1:1? I was already very worried about this pregnancy, since we are not sure yet whether my identical twins are mo-di or mo-mo (mo-mo only has a 50% survival rate). Its a high risk pregnancy either way. I will be monitored very closely to make sure the twins dont develop twin to twin transfusion syndrome. I will most likely have ultrasounds every two weeks. Now that I know about this new twist - with the E antibodies - I am terrified! Please share any info or your experiences with anti-E. How worried should I be at this point? Thanks!
Ricki: Theyre form. Neck. Shoulders. Legs. Hips. I think pretty cool. Now as far as your famous penis goes, the penis is like some sort of bizarre sea slug, or like a really long toe. I mean, its handy. Important even. But the pinnacle of sexual design? The top of the list of erotic destinations? I dont think so. Ones first impulse is to kiss. What? To kiss the lips. Firm, delicious, lips. Sweet lips. Surrounding a warm moist dizzingly scented mouth. Thats what everyone wants to kiss. Not a toe. Not a sea slug. A mouth. And why do you think that is, Stupid? Because the mouth is the twin sister, the almost exact look-alike of the what? Not the toe. The mouth is the twin sister of the vagina. And all creatures big and small seek the orifice, the opening to … to be taken in. Engulfed. To be squeezed and lovingly crushed by what is truly the all-powerful, all-encompassing.… No, if it is design youre concerned with, hidden meanings, symbolism, power.… No, forget the top of Mt. Everest. ...
"Centers for Disease Control and Prevention. Retrieved 7 December 2014.. *^ "Hydrocephalus". Mayo Clinic. Retrieved 7 December ... This results in conditions such as conjoined twins, and the resulting merged organism may die at birth when it must leave the ... Centers for Disease Control and Prevention. *^ a b "Facts about Cleft Lip and Cleft Palate , Birth Defects , NCBDDD , CDC". www ... "WHO Disease and injury country estimates". World Health Organization. 2009. Retrieved Nov 11, 2009.. ...
"Hypertensive Disease in Twin Pregnancies: A Review". Twin Research. 5 (1): 8-14. doi:10.1375/1369052022848. PMID 11893276. "[ ... Center for Disease Control. Retrieved 22 September 2016. Engebretson, Joan (2013). Materinity Nursing Care. Canada: Nelson ... ISBN 0-309-05230-0. Centers for Disease Control and Prevention. 2007. Preventing Smoking and Exposure to Secondhand Smoke ... There is evidence that breastfeeding offers protection against many infectious diseases, especially diarrhea. Even in babies ...
"Twin Cities. 2017-07-05. Retrieved 2018-04-22.. *^ "Medical Cannabis Qualifying Conditions - Minnesota Dept. of Health". www. ... Lou Gehrig's Disease), a seizure disorder, Multiple Sclerosis, Crohn's Disease, or a painful terminal illness with less than a ... "Twin Cities. 2018-11-25. Retrieved 2019-04-13.. *^ Reed, Ryan (2019-01-28). "Minnesota Introduces Bill for Marijuana ... "Minnesota OKs medical cannabis for chronic pain, eye disease". Retrieved 2019-12-03.. ...
Ballestar E (2010). "Epigenetics lessons from twins: prospects for autoimmune disease". Clin Rev Allergy Immunol. 39 (1): 30-41 ... Twins[edit]. Direct comparisons of identical twins constitute an optimal model for interrogating environmental epigenetics. In ... A more recent study, where 114 monozygotic twins and 80 dizygotic twins were analyzed for the DNA methylation status of around ... epigenetic differences in monozygotic twins and implications for twin studies in psychiatry". American Journal of Medical ...
An extreme case of this was seen where monozygotic female twins had extreme variance in expression of Menkes disease (an X- ... "Menkes disease with discordant phenotype in female monozygotic twins". American Journal of Medical Genetics. Part A. 167A (11 ... Puck JM, Willard HF (January 1998). "X inactivation in females with X-linked disease". The New England Journal of Medicine. 338 ... For example, a female heterozygous for haemophilia (an X-linked disease) would have about half of her liver cells functioning ...
An extreme case of this was seen where monozygotic female twins had extreme variance in expression of Menkes disease (an X- ... "Menkes Disease with Discordant Phenotype in Female Monozygotic Twins". Am. J. Med. Genet. A. 167 (11): 2826-829. doi:10.1002/ ... Puck, J; Willard, HF (1998). "X Inactivation in Females with X-Linked Disease". N. Engl. J. Med. 338 (5): 325-8. doi:10.1056/ ... For example, a female heterozygous for haemophilia (an X-linked disease) would have about half of her liver cells functioning ...
The twins died on the same day[which?] from the same disease[which?], and are buried together in the Locust Grove Cemetery in ... Twinsburg holds a yearly festival for twins, and other multiple births, called Twins Days. Non-twins are also welcome to attend ... The twins offered 6 acres (24,000 m2) of land for a public square and twenty dollars to support the town's first school on the ... The festival attracts twins, multiples and their families from much of the world, many sets returning year after year. ...
ISBN 978-603-00-3797-1. "Separated Sudanese conjoined twins moved to pediatric ward". 6 November 2016. "Conjoined Twins:التوائم ... "King Abdullah Centre for Oncology and Liver Diseases , King Faisal Specialist Hospital & Research Centre". King Faisal ... Initially, the conjoined twins team consisted of only 10% Saudis, today it boasts all Saudi members in the different ... Accepting the challenge, Al Rabeeah agreed to the late King Abdullah's request and performed the surgery on the twins in ...
"Parkinson disease in twins: an etiologic study". JAMA. 281 (4): 341-6. doi:10.1001/jama.281.4.341. PMID 9929087. Langston JW, ... Parkinson's Disease is only suffered by humans but animal testing is essential in drug development. Now Parkinson's Disease ... the etiology of Parkinson's disease, and the development of new strategies to slow or halt disease progression such as cell ... During an interview in 2009 Langston stated: "I would never promise I could solve the disease. What I would do is say, I think ...
This can help suggest whether a disease or a certain trait has a genetic cause. Controversial uses of twin data have looked at ... Twin studies[edit]. A twin study compares the concordance rate of identical twins to that of fraternal twins. ... "Inherent similarities in identical twins may not be so strong ( Identical twins may be more different f...)". ... The expression of the epigenetic effect is typically weakest when the twins are young and increases as the identical twins grow ...
"Historic Preston Park Twin to be felled following elm disease infection". Brighton and Hove City Council. 4 July 2019. ... The Preston Twins in Preston Park, Brighton, England, are the two oldest English elms in the world. Both trees are aged over ... Yarmouth, Cumberland County (removed in 2010 due to Dutch elm disease) 244 inches (620 cm) 110 feet (34 m) 129 feet (39 m) 386 ... Main Street, Old Deerfield, Franklin County (removed in 2017 due to Dutch elm disease) 230.4 inches (585 cm) 104.4 feet (31.8 m ...
Twin Valley Veterinary Health Services". Retrieved 2017-04-06. "NMSU: Sheep Production & Management - White Muscle Disease- ... The diseases are characterized by the damage and degeneration of the central nervous system. This disease process is heritable ... Nutritional Muscular Dystrophy (Nutritional Myopathy or White Muscle Disease) is a disease caused by a deficiency of selenium ... The disease may also present in the form of respiratory distress. in a heifer same animal in a lamb other lamb Description of ...
Ballestar E (August 2010). "Epigenetics lessons from twins: prospects for autoimmune disease". Clinical Reviews in Allergy & ... A more recent study, where 114 monozygotic twins and 80 dizygotic twins were analyzed for the DNA methylation status of around ... epigenetic differences in monozygotic twins and implications for twin studies in psychiatry". American Journal of Medical ... Congenital genetic disease is well understood and it is clear that epigenetics can play a role, for example, in the case of ...
The course of the disease is progressive.[2][8] Depending on the severity of the disease, alpha-mannosidosis has been ... A. Twins aged 18 Months. Note enlarged head, short neck, rounded eyebrows, saddle nose, and prominent forehead. B. Same twins ... 1987). "Bone marrow transplantation in the treatment of alpha-mannosidosis". Disease in Childhood. 62 (10): 1044-1049. doi: ... Enzyme replacement therapy (ERT) is a therapeutic alternative in a number of lysosomal storage diseases.[2][7] The overall ...
Acu-Gen claimed that their kit could predict a mixed sex set of fraternal twins, so the test should have predicted twins ... The kit did not require regulation since it did not diagnose, prevent or treat a disease. The company was not obliged to ... The company claimed that their kit could detect twins. The test was featured on an episode of The Today Show in June 2005.[dead ... including one for a case involving a vanishing twin. The states that none of the refund checks were issued ...
... a Twin Study". Journal of Nervous and Mental Disease. 190 (4): 219-224. doi:10.1097/00005053-200204000-00002.. ... BFNE scores have been found to have a genetic component in twin studies. In addition, BFNE scores and the Dimensional ...
Some disease like coeliac disease primarily associate with certain genes. While other diseases, like type 1 diabetes may have ... Each person has unique chromosomes, unless they are identical twins. These unique chromosomes are produced by recombination of ... which may also increase the risk of autoimmune disease in both Coeliac Disease and Type 1 diabetes. In systemic lupus ... DQ2 are believed to also contribute to autoimmune disease. Also a dozen inflammatory diseases of the immune system can ...
"Markers of Viral Infection in Monozygotic Twins Discordant for Chronic Fatigue Syndrome". Clinical Infectious Diseases. 35 (5 ... Systemic Active Infections in Patients with Early Disease". Clinical Infectious Diseases. 31 (4): 894-903. doi:10.1086/318141. ... HHV-6 (and HHV-7) levels in the brain are also elevated in people with Alzheimer's disease. HHV-6B primary infection is the ... HHV-6A includes several adult-derived strains and its disease spectrum is not well defined, although it is thought by some to ...
Helmberg A (August 1993). "Twin genes and endocrine disease: CYP21 and CYP11B genes". Acta Endocrinologica. 129 (2): 97-108. ... Lenders JW, Williams TA, Reincke M, Gomez-Sanchez CE (January 2018). "DIAGNOSIS OF ENDOCRINE DISEASE: 18-Oxocortisol and 18- ... Padmanabhan N, Padmanabhan S, Connell JM (December 2000). "Genetic basis of cardiovascular disease--the renin-angiotensin- ...
Helmberg A (August 1993). "Twin genes and endocrine disease: CYP21 and CYP11B genes". Acta Endocrinol. 129 (2): 97-108. doi: ... Lenders JW, Williams TA, Reincke M, Gomez-Sanchez CE (January 2018). "DIAGNOSIS OF ENDOCRINE DISEASE: 18-Oxocortisol and 18- ...
Helmberg A (August 1993). "Twin genes and endocrine disease: CYP21 and CYP11B genes". Acta Endocrinologica. 129 (2): 97-108. ... A study of the steroidogenic capacity of the adrenal cortex in infants with acute respiratory disease demonstrated that indeed ... "Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants". European Journal of ... during disease state there is a specific increase in the steroidogenic capacity for the synthesis of the glucocorticoid ...
Twins[edit]. For otherwise healthy twin pregnancies where both twins are head down a trial of vaginal delivery is recommended ... "Centers for Disease Control and Prevention. March 2010. Archived from the original on 17 May 2012. Retrieved 16 June 2012.. ... The consensus concerning monoamniotic twins (identical twins sharing an amniotic sac), the highest risk type of twins, is that ... the medical literature recommends delivery of dichorionic twins at 38 weeks, and monochorionic twins (identical twins sharing a ...
... neurological disease. Benjamin LaGuer, 57, American convicted rapist, liver disease. Naomi Long Madgett, 97, American poet. ... Carol Arthur, Actress in 'Blazing Saddles' and Wife of Dom DeLuise, Dies at 85 Julio Becquer, member of Twins' first team in ... Julio Bécquer, 88, Cuban baseball player (Washington Senators, Los Angeles Angels, Minnesota Twins). Tonny Bruins Slot, 73, ... Tom Metzger, 82, American white supremacist, founder of White Aryan Resistance, Parkinson's disease. John Meyer, 78, American ...
Both twins are exposed to the changing political environment in Ethiopia. There is an unsuccessful rebellion by Haile ... The book contains descriptions of many medical diseases and interventions. The title relates to the oath of Hippocrates that ... It is a saga of twin brothers, orphaned by their mother's death at their births and forsaken by their father. The book includes ... The tissue link between the twins has been separated at birth and the two grow up together being very close initially. ...
They had twin sons in February 1984, Piotr and Paweł. Their third child, daughter Maria, died a few hours after her birth in ... She suffered from a heart disease. Krzysztof worked as a businessman but had no successes. In 2002 he had a romance with his ...
She lost one twin to sickle cell disease in 2012. The University of York, where she was a student, have an award in her honour ... In 2015 she was elected a Fellow of the Royal Society of Chemistry (FRSC). Karodia has twin daughters, both of whom studied ...
Ed Schwartz, 62, American radio personality, kidney and heart disease. Mark Shepherd, 86, American chairman of Texas ... Twins, Indians, Reds), heart attack. Aasiya Zubair, 37, American businesswoman, co-founder of Bridges TV, beheaded. Notable ... Louie Bellson, 84, American jazz drummer, complications from Parkinson's disease. Geoffrey Collin, 87, British army general. ... Gazanfer Özcan, 78, Turkish actor, respiratory disease. Robert Robideau, 61, American Native Americans activist. Shabnam Romani ...
... and thyroid disease. Both bacterial as well as viral pathogens have been implicated in the etiology of LS. A disease that is ... Higher rates of lichen sclerosus have been reported among twins and among family members. Autoimmunity is a process in which ... The disease can last for a considerably long time. Occasionally, "spontaneous cure" may ensue, particularly in young girls. ... A link with Lyme disease is shown by the presence of Borrelia burgdorferi in LSA biopsy tissue. Since LS in females is ...
"UMN named a Udall Center of Excellence in Parkinson's Disease Research". September 22, 2016. Retrieved ... In September 2016, Vitek was appointed Director of the Udall Center of Excellence in Parkinson's Disease Research to improve ... and his current research activities focus on Parkinson's disease, dystonia, tremor and deep brain stimulation. Vitek completed ... began exploring the use of electrical stimulation of precise areas of the brain in order to get rid of Parkinson's disease. He ...
Diseases of the endocrine system (ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases - Endocrine diseases, E00- ... "The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin ... Diabetes was one of the first diseases described.[21] The importance of insulin in the disease was determined in the 1920s.[22] ... two to four times the risk of cardiovascular disease, including ischemic heart disease and stroke; a 20-fold increase in lower ...
Brown added twin fiddles, tenor banjo and slap bass, pointing the music in the direction of swing, which they played on local ... Infectious disease deaths in Texas. *Songwriters from Texas. *Songwriters from Oklahoma. *Singers from Oklahoma ...
In June 2004, Saint Barnabas Medical Center delivered a 23-week-old twin boy with weight of 320 grams. The boy was hospitalized ... the 3rd highest score in New Jersey for Kidney disease; and the 4th highest score in New Jersey for Cancer, Gynecology, and ...
Twin births have not been reported.[2]. The calf has a tawny, shaggy coat and weighs about 11 kg (24 lb). By the end of the ... Diseases and parasitesEdit. The black wildebeest is particularly susceptible to anthrax, and rare and widely scattered ... Malignant catarrhal fever is a fatal disease of domestic cattle caused by a gammaherpesvirus. Like the blue wildebeest, the ... Wild individuals can be competitors of commercial livestock, and can transmit fatal diseases such as rinderpest, and cause ...
This article is about a skin disease common during adolescence. For other acneiform skin diseases, see Acne (disambiguation). ... Studies performed in affected twins and first-degree relatives further demonstrate the strongly inherited nature of acne.[2][15 ... Disease Primers. 1: 15033. doi:10.1038/nrdp.2015.33. PMID 27227877.. *^ a b "Frequently Asked Questions: Acne" (PDF). U.S. ... Acne, also known as acne vulgaris, is a long-term skin disease that occurs when dead skin cells and oil from the skin clog hair ...
List of systemic diseases with ocular manifestations. References[edit]. *^ a b c Matejcek, A; Goldman, RD (November 2013). " ... The disease incidence varies widely depending on the geographical location. The most extensive epidemiological survey on this ... "Red Book-Report of the Committee on Infectious Diseases, 29th Edition. The American Academy of Pediatrics". Retrieved 2007-07- ... In addition to the incidence of this sight threatening infection they also investigated the time trends of the disease. ...
Graft-versus-host disease[edit]. Main article: Graft-versus-host disease. Graft-versus-host disease (GVHD) is an inflammatory ... twin of the patient - necessarily extremely rare since few patients have an identical twin, but offering a source of perfectly ... Veno-occlusive disease[edit]. Severe liver injury can result from hepatic veno-occlusive disease (VOD). Elevated levels of ... Major complications are veno-occlusive disease, mucositis, infections (sepsis), graft-versus-host disease and the development ...
Those with certain diseases, and those over the age 35 also run a greater risk. Other causes for abortions can be the infection ... reducing the number of fetuses to lower the health risks associated with a multiple pregnancy (like twins) ... Certain diseases or an accidental trauma can also cause a spontaneous abortion. Putting the woman under trauma or stress to ... abortion may be caused by contagious diseases, such as Brucellosis or Campylobacter. This can often be controlled by ...
Monozygotic and dizygotic twins[edit]. Further information on the terms "monozygotic" and "dizygotic": Twin ... Sometimes, one allele is a disease-causing variation while the other allele is healthy. Sometimes, the different variations in ... Identical twins are monozygotic, meaning that they develop from one zygote that splits and forms two embryos. Fraternal twins ... may also be used to describe the genetic similarity or dissimilarity of twins.[6] ...
Thousands of inhabitants[citation needed] of Casale have died from mesothelioma,[5] a fatal disease caused by the breathing of ... Within five years it achieved the twin peaks of its success: in 1913 it became the first Italian club to beat an English ...
A common example of pleiotropy is the human disease phenylketonuria (PKU). This disease causes mental retardation and reduced ... evidence from a meta-analysis of twin studies". Archives of General Psychiatry. 60 (12): 1187-1192. doi:10.1001/archpsyc.60.12. ... "Complications and Treatments , Sickle Cell Disease". CDC. Retrieved 2016-11-11.. *^ a b c d "Marfan Syndrome". National ... "sickle cell disease". Genetics Home Reference. Retrieved 2016-11-11.. *^ MD, Kenneth R. Bridges. "How Does Sickle Cell Cause ...
Paterson, Sue (December 17, 2007). Skin Diseases of Exotic Pets. Blackwell Science, Ltd. pp. 74-79. ISBN 9780470752432. .. ... and the Nahuatl word coatl meaning serpent or twin, forms part of primary deities such as Mixcoatl, Quetzalcoatl, and Coatlicue ... Hellebuyck, Tom; Pasmans, Frank; Haesbrouck, Freddy; Martel, An (July 2012). "Dermatological Diseases in Lizards". The ... a common skin disease in snakes and lizards, will occur when ecdysis, or shedding, fails.[94] There are numerous reasons why ...
When the sacral dorsal roots are cut in experimental animals or interrupted by diseases of the dorsal roots such as tabes ...
Mitchell misdiagnosed the disease that he observed and treated, and that the disease was probably Weil's disease, or hepatitis ... after a report of 15-month-old twins being orphaned, two days later the committee had identified a house for sheltering the ... Webster, Noah, A Brief History of Epidemic Disease, 1798. *^ LaRoche, Yellow Fever, considered in its historical, pathological ... Devèze, Jean (1794). An Inquiry into and Observations upon the Causes and Effects of the Epidemic Disease Which Raged in ...
Diving Diseases Research Centre (DDRC). *Diving Medical Advisory Council (DMAC). *European Diving Technology Committee (EDTC) ... Twin-hose regulator. *Full face diving mask. Open-circuit. scuba. *Scuba set *Bailout bottle ...
... goddess of disease and rain Shitala Devi, goddess of smallpox and disease Jvarasura, god of fever Paranasabari, diseases ... twin doctors of the gods and gods of Ayurvedic medicine Dhanvantari, physician of the gods and god of Ayurvedic medicine Dhatri ... Agwu, Igbo god of health and divination Jengu, water spirits that bring good fortune and cure disease !Xu, sky god of the ... god of death and disease Ninazu, god of the underworld and healing Ningishzida, god of the underworld and patron of medicine ...
85% of MGN cases are classified as primary membranous glomerulonephritis-that is to say, the cause of the disease is idiopathic ... The twin aims of treating membranous nephropathy are first to induce a remission of the nephrotic syndrome and second to ... A large part of this difficulty is due to a lack of ability to predict which people will progress to end-stage kidney disease, ... Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly people between ages of 30 ...
Aging and Disease. 2013, 4 (6): 320-28. ISSN 2152-5250. doi:10.14336/AD.2013.0400320.. ... Predictive factors of age at menopause in a large Australian twin study. Hum Biol. 1998, 70 (6): 1073-91. PMID 9825597.. ... Disease mongering of age-associated declines in testosterone and growth hormone levels.. Journal of the American Geriatrics ... Tersigni C, Castellani R, de Waure C, Fattorossi A, De Spirito M, Gasbarrini A, Scambia G, Di Simone N. Celiac disease and ...
... respiratory diseases, skin diseases, wounds, ulcer, gout, and rheumatism.[8] ...
"Batumi - Twin Towns & Sister Cities". Batumi City Hall. Archived from the original on May 4, 2012. Retrieved August 10, 2013.. ... the city suffered repeated epidemics of yellow fever and other tropical and infectious diseases. ... The Twin Span Bridge, a five-mile (8 km) causeway in eastern New Orleans, carries I-10 across Lake Pontchartrain. Also in ...
I-91's majestic twin-structure West River Bridge is, as of 2015, being rebuilt with a completely new design.[94] ... in the Cure of Acute and Chronic Diseases". in Fowlers and Wells' Water-Cure Library: Embracing all the most popular works on ...
Cardiovascular disease (post heart attack recovery, circulatory problems); Valvular disease of the heart muscle, hypertension, ... The town is twinned with: Budapest 18th district, Hungary Harkány, Hungary Jászkarajenő, Hungary Orosháza, Hungary Bicske, ... Basedow's disease); Spa with CO2, mofettes, galvanic baths, massage; Paraffin, herbal baths, massage; Magneto-diaflux, ... stomach diseases, functional bowel disorders, chronic gastritis, enterocolitis, biliary dyskinesia); Endocrine disorders ( ...
45.0 45.1 Smyth, S; Heron, A (2006 Jan). "Diabetes and obesity: the twin epidemics". Nature medicine 12 (1): 75-80. doi:10.1038 ... Ripoll, Brian C. Leutholtz, Ignacio (2011-04-25). Exercise and disease management (2nd ). Boca Raton: CRC Press. பக். 25. ... "National Diabetes Information Clearinghouse (NDIC) (National Institute of Diabetes and Digestive and Kidney Diseases, NIH). ... Christian, P; Stewart, CP (2010 Mar). "Maternal micronutrient deficiency, fetal development, and the risk of chronic disease". ...
In the 1960s the East End was the area most associated with gangster activity, most notably that of the Kray twins.[123] The ... Over the course of a century, the East End became synonymous with poverty, overcrowding, disease and criminality.[11] ... However, with the rise of the Kray twins in the 1960s the dark side of East End character returned with a new emphasis on ... Eventually, the passage of the Contagious Diseases Prevention Act in 1864 allowed policemen to arrest prostitutes and detain ...
... to a twin or singleton pregnancy. When the fetus targeted for termination displays signs of a serious disease, the term ... yet both resultant twins or singletons are much less risky than attempting to carry the triplets (15%). Reduction from twins to ... Triple to twins reduction has statistically shown better pregnancy outcome with premature birth before 32 weeks reduced to 10.1 ... This is a less common but growing practice as the risks in twin pregnancies, while existent, are much lower than in higher- ...
... stress before birth and in some cases exposure to infectious diseases (a disease that spreads from person to person).[16] In ... Identical twins are much closer and are treated much more in the same way, and this may be the reason why one of them is more ... The risk is even higher if you have an identical twin with schizophrenia.[17] This may seem to show that schizophrenia is ... In 2002, the term for schizophrenia in Japan was changed from "Seishin-Bunretsu-Byō" 精神分裂病 ("mind-split-disease") to "Tōgō- ...
The unexplained deaths and illnesses at Shenandoah immediately caught the attention of the Centers for Disease Control (CDC). ...
... an extremely rare disease which inhibits the sensation of pain, heat and cold. There have been nearly 40 reported cases in the ... Gällivare is twinned with Barga in Tuscany, Italy. Gällivare was the filming spot for Avicii's single Addicted To you. ...
Two of every five common diseases are at least partially influenced by a persons genetics, the largest U.S. study of twins ... Diseases that tend to strike identical twin pairs at a higher rate than fraternal twins or siblings are probably influenced by ... Twin studies are valuable because identical twins share 100 percent of their genetics, while fraternal twins and siblings share ... "Maybe this disease isnt worth our investment to genotype if you see within a twin study the genetic role is low," Lakhani said ...
... reports which epigenetic factors in certain chromosomes that make one twin more at risk for autoimmune thyroid diseases. ... including autoimmune thyroid diseases, such as Graves disease and Hashimotos disease. In these diseases, the body produces ... Immune diseases inflict identical twins differently Osaka University scientists explain why only one identical twin is at risk ... Immune diseases inflict identical twins differently. Osaka University. Journal. Thyroid. Funder. Japan Society for the ...
Monozygotic Twins Discordant for Kennedy Disease: A Case Report.. Popescu C1. ... Disease began at age 31 for the first brother, respectively, and at 56 years for the second one and consisted of muscle wasting ... To the best of our knowledge, this is the first case describing CAG trinucleotide repeats in monozygotic twins and also the ... Spinal and bulbar muscular atrophy or Kennedy disease (KD) is an X-linked recessive disorder caused by a pathogenic CAG ...
Cottam and her twin girls survived, although she spent 22 hours in a coma at Countess of Chester Hospital in Britain. She had a ... The twins stayed two weeks in intensive care. Since then, she has been in counseling for trauma, which Cottam said, "has helped ... "It wasnt until a medic informed me that I was OK and that the twins were in neonatal but doing well, that I was realized that ... "As I lay in ICU, Peter, my husband, went to hell and back with thoughts about life alone with twins and our 4-year-old daughter ...
Does low birthweight predispose to Perthes disease? Perthes disease in twins. J Pediatr Orthop B. 2003;12(5):307-310pmid: ... The Danish Twin Registry: 127 birth cohorts of twins. Twin Res. 2002;5(5):352-357pmid:12537858. ... A Twin Study of Perthes Disease. David Metcalfe, Stephanie Van Dijck, Nicolas Parsons, Kaare Christensen and Daniel C. Perry ... twins ∼50%.17 If monozygotic twins exhibit a greater concordance of LCPD than dizygotic twins, this suggests a genetic basis ...
But sometimes rheumatoid arthritis, cancer, or another malady strikes one twin and not the other. What leads to such seemingly ... as well as the genes that boost risk for diseases. ... Identical twins share the same set of genes, such as ones for ... When Only One Twin Gets a Disease. Studying how gene expression differs in identical twins could shed light on how genes and ... And both members of an identical twin pair dont usually have the disease; if one twin has it, the other will have it about 15 ...
Slidell twin brothers were diagnosed with liver disease. One brother recently died. Their Slidell High School community sent ... community sends birthday wishes to twins with liver disease. Slidell twin brothers were diagnosed with liver disease. One ...
Twins battling rare disease tour Six Flags… Share this:. *Click to share on Twitter (Opens in new window) ... The average life span for someone with the disease is 27 years, and the average age for requiring a kidney transplant is 16 ... On Monday, Patrick and his twin sister, Jenna, along with their mother, Theresa Partington, and great aunt, received a personal ... The outing was also special because it took the twins minds off their health issues, at least temporarily. ...
deer positive for chronic wasting disease Share this:. *Click to share on Facebook (Opens in new window) ... All were within a 10-mile radius of the location near Pine Island where a deer tested positive for the disease in November. ... PAUL, Minn.-The Minnesota Department of Natural Resources says testing for chronic wasting disease is finished and no deer were ... Although 900 samples wouldve provided the best estimate of the diseases prevalence, it wasnt an all or nothing goal, the ...
... Share this:. *Click to share on Facebook (Opens in new window) ... WINSTON-SALEM, N.C.-Eighteen patients at a North Carolina hospital may have been exposed to a rare neurological disease after ... The patient was confirmed to have sporadic CJD, which has been associated with mad cow disease. But this particular strain ... President Jeff Lindsay told a news conference Monday that 18 patients may have been exposed to Creutzfeldt-Jakob Disease. A ...
Findings indicate a substantial genetic effect for these predominantly late-onset Alzheimers disease cases. At the same time, ... Heritability for Alzheimers disease: the study of dementia in Swedish twins J Gerontol A Biol Sci Med Sci. 1997 Mar;52(2):M117 ... Background: Alzheimers disease has been thought to have familial and sporadic forms, and several genetic defects have been ... In this study, our purpose was to detect all cases of dementia in an established twin registry and to estimate total extent of ...
All vladwiels Items,Epidemiology Seminar Series,Low birth weight and risk of chronic disease lessons from twins - Flash ( ... Low_birth_weight_and_risk_of_chronic_disease_lessons_from_twins_-_Flash_(Medium)_-_20121018_03.51.31PM.mp4. 32.22MB ... Low_birth_weight_and_risk_of_chronic_disease_lessons_from_twins_-_Flash_(Medium)_-_20121018_03.51.31PM_xmp.xml ... Low_birth_weight_and_risk_of_chronic_disease_lessons_from_twins_-_Flash_(Medium)_-_20121018_03.51.31PM.html ...
Our identical twins Tim and Cary were born 11 weeks early after developing Twin to Twin Transfusion Syndrome (TTTS) where one ... TWINS™ Magazine has been loved by families of twins since 1984. We are the premier publication for everything TWINS!. Contact ... With us, we were told Chronic Lung Disease is something our twins would likely outgrow. Sure, they sent us to a pulmonologist ... Twins Magazine may receive commissions when you click our product review links and make purchases. This does not impact our ...
Discordant disease expression of neonatal lupus erythematosus in twins. by Journal of Pakistan Medical Association; Health, ... APA style: Discordant disease expression of neonatal lupus erythematosus in twins.. (n.d.) >The Free Library. (2014). Retrieved ... MLA style: "Discordant disease expression of neonatal lupus erythematosus in twins.." The Free Library. 2017 Asianet-Pakistan ... Twin 1###Twin 2. Gender###Female###Female. Weight###2.2 kg###1.9 kg. APGAR score###At 1 minutes = 7###At 1 minutes = 8. ###At 5 ...
Depression is a recognized risk factor for coronary heart disease (CHD) and, by studying pairs of twins, researchers from Emory ... The scientists studied 50 pairs of male twins between the ages of 47 and 57 who were free of symptomatic CHD. Twenty-four hour ... "And these results are even more remarkable for the fact that they are derived from twin study design, which is semi- ... She adds that the results of the twin study are important not only because they provide an explanation for how depression ...
Disease,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news ... Twins Freddie and Thomas Greenstreet were born two weeks ago to parent... The Greenstreets already have a daughter affected by ... of diseases such as CF, sickle cell disease, Huntingtons disease, Duchenne muscular dystrophy and spinal muscular atrophy. ... First Embryos in UK Screened for Disease. Twins Freddie and Thomas Greenstreet were born two weeks ago to parent... The ...
The female twins were born at 38 weeks of gestation by caesarean section. Obstetric anamnesis was normal. The twins past ... and development in identical twins may indicate that genetic factors have a role in the occurrence of this disease. Larger ... mixed connective tissue disease, systemic lupus erythematosus, occlusive vascular disease, drug effects, haematological ... The twins were admitted to the dermatology department with a one year history of the sudden onset of episodic purple lesions on ...
07Teen Twins Triumph Over Celiac Disease. You might also like. Researchers Find Striking Associations Between Celiac Disease ... Teen Twins Triumph Over Celiac Disease June 18, 2018. /in Gluten-Free News /by Ellen Bayens. ... You are here: Home / Gluten-Free News / Teen Twins Triumph Over Celiac Disease ... Celiac disease is an autoimmune disorder that causes damage in the small intestine. People with celiac disease respond ...
Discordance for congenital heart disease was observed in the twins: Twin A presented with pulmonary atresia with an intact ... Fetal Diagnosis of Left-Ventricular Noncompaction Cardiomyopathy in Identical Twins With Discordant Congenital Heart Disease. ... Monochorionic twins discordant for congenital heart disease: a referral centers experience and possible pathophysiologic ... Congenital heart disease Fetal diagnosis Noncompaction cardiomyopathy Electronic supplementary material. The online version of ...
Cardiovascular Disease Mortality in The NAS-NRC Twin Registry. The safety and scientific validity of this study is the ... To analyze cardiovascular disease mortality and total mortality in the NAS-NRC Twin Registry using a new methodology that ... 16-year incidence of ischemic heart disease in the NHLBI twin study. A classification of subjects into high- and low-risk ... Carmelli D, Swan GE, Robinette D, Fabsitz R. Genetic influence on smoking--a study of male twins. N Engl J Med. 1992 Sep 17;327 ...
A pair of identical female twins with ophthalmic Graves disease is described. Monozygosity was confirmed by analysis of blood ...
Poverty: A childhood disease with lifelong consequences?. By Cynthia Boyd () , July 1, 2010. Tweet. ... Twin Cities Daily Planet ( ... Calling poverty "a childhood disease" with life-long repercussions and costs for both children and society, Chase asked: "How ...
In human defenses against disease, environment beats heredity, study of twins shows. Author Bruce GoldmanPublished on January ... the researchers recruited 78 identical-twin pairs and 27 pairs of fraternal twins and drew blood from both members of each twin ... Identical twins inherit the same genome, while fraternal twin pairs are no more alike genetically than regular siblings, on ... If members of identical-twin pairs are found to be no more alike than members of fraternal-twin pairs with respect to the ...
Comparing blood pressure of twins and their singleton siblings: being a twin does not affect adult blood pressure. Twin ... Ischaemic heart disease and low birth weight: a test of the fetal-origins hypothesis from the Swedish Twin Registry. Lancet ... Mortality among twins after age 6: fetal origins hypothesis versus twin method. British Medical Journal 1995; 310: 432-436.. * ... Morley, R. and Dwyer, T. (2005), Studies of twins: what can they tell us about the fetal origins of adult disease?. Paediatric ...
... ABC 2, Sept 7, 2010 ... Home - Washington, DC, Fertility Guide - Patient with Polycystic Ovary Disease Has Twins Thanks to Fertility Treatment ... When twins Bryden and Zoey made their big debut 16 months ago, everything changed. Glenn says, "Its changed for the better. I ... Joann had fertility issues and was diagnosed with polycystic ovarian disease, a condition that makes it difficult to get ...
OBJECTIVES: To investigate the cause of sporadic motor neuron disease (MND) by twin study, so allowing (1) estimation of the ... Inspection of individual birth entries allowed identification of potential twins. The status of each co-twin was determined and ... CONCLUSIONS: This "death discordant" method for twin collection has proved to be viable, and has allowed the ascertainment of a ... The diagnosis of MND was verified via the co-twin and relatives, and medical records where available. Zygosity was assessed ...
Parkinson Disease. Parkinsonian Disorders. Basal Ganglia Diseases. Brain Diseases. Central Nervous System Diseases. Nervous ... Parkinsons Disease. twins. SPECT. National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins ... Twins and the Risk of Parkinsons Disease: A Clinical and Imaging Study. The safety and scientific validity of this study is ... Onset of Parkinsons disease [ Time Frame: duration of the project ]. Secondary Outcome Measures : *Age of Parkinsons disease ...
Furthermore, the study included 21 non-twin patients with ulcerative colitis, 18 non-twin patients with Crohns disease, and 52 ... This study analysed P-ANCA in monozygotic twins with inflammatory bowel disease to evaluate this hypothesis further. P-ANCA was ... In ulcerative colitis P-ANCA occurred in nine of 14 (64.3%) monozygotic twins and in 13 of 21 (61.9%) non-twin cases, which was ... immunofluorescence technique in 12 monozygotic twin pairs with ulcerative colitis and 14 twin pairs with Crohns disease. ...
Through within-twin analyses, we aimed to minimize confounding effects such as twins that share genetic and early environmental ... However, when comparing discordant twin pairs in within-twin pair analyses, there was no statistically significant association ... and we included 407 discordant pairs of CD-non-CD twins. Comparing the 669 CD patients with non-CD twins, the association ... exposures.Materials and methods: Using the Swedish Twin Registry, we examined the birth weight of 146,830 twins according to ...
"Integrated Analysis of Gene Expression Differences in Twins Discordant for Disease and Binary Phenotypes." Scientific Reports 8 ... Integrated Analysis of Gene Expression Differences in Twins Discordant for Disease and Binary Phenotypes. ... One way to identify environmental influences is through a discordant monozygotic (MZ) twin study design. Here, we assessed ... differential gene expression in MZ discordant twin pairs (affected vs. non-affected) for seven phenotypes, including chronic ...
  • The overall probandwise concordance was 0.09 (95% confidence interval [CI]: 0.01-0.18): 0.00 for the monozygotic, 0.08 (95% CI: 0.00-0.18) for the dizygotic, and 0.18 (95% CI: 0.00-0.40) for the UZ twin pairs. (
  • In this study, investigators will use the NAS/NRC WWII Veteran Twin Cohort Registry to compare the concordance rates for PD in monozygotic and dizygotic twins-at least one of whom has PD. (
  • However, the association was not significant in within-pair analyses for both dizygotic and monozygotic twins and for both sexes. (
  • A large sample of 3930 female monozygotic and dizygotic twins from the UK Adult Twin Registry (TwinsUK) was questioned about the presence of a DED diagnosis and about DED symptoms in the preceding 3 months. (
  • All DED outcome variables showed higher correlation in monozygotic twin pairs than in dizygotic twin pairs, suggesting genes have a contributory role in DED. (
  • Interestingly, the observed differences remained when healthy monozygotic and dizygotic twin siblings were analyzed separately. (
  • Conclusions:We observed increased NF-B, MPO, and FC in healthy twins in both monozygotic and dizygotic discordant pairs with IBD. (
  • Twinning, Dizygotic, also known as ovarian response to fsh stimulation , is related to neonatal alloimmune neutropenia and premature ovarian failure 1 . (
  • An important gene associated with Twinning, Dizygotic is FSHR (Follicle Stimulating Hormone Receptor), and among its related pathways/superpathways is Ovarian Infertility Genes . (
  • Among seven monozygotic (MZ), eight same-sex dizygotic (DZss) and five opposite-sex dizygotic (DZos) twin pairs, one MZ and one DZss were concordant for SLE. (
  • In contrast, a pair of fraternal twins is produced when two oocytes (dizygotic, DZ) are released at a single ovulation and fertilized by two different sperm at the same time, resulting in the same type of genetic relationship as siblings. (
  • Compare this process with the development of fraternal twins, known by the scientific name dizygotic twins - with the prefix "di" meaning two. (
  • Scientists might skip this step for diseases that are clearly not influenced by genetics. (
  • Twin studies are valuable because identical twins share 100 percent of their genetics, while fraternal twins and siblings share about half their genetics, on average, said senior researcher Chirag Patel, an assistant professor of biomedical informatics at Harvard Medical School. (
  • Diseases that tend to strike identical twin pairs at a higher rate than fraternal twins or siblings are probably influenced by genetics, Lakhani said. (
  • Identical twins inherit the same genome, while fraternal twin pairs are no more alike genetically than regular siblings, on average sharing 50 percent of their genes. (
  • If members of identical-twin pairs are found to be no more alike than members of fraternal-twin pairs with respect to the presence of some trait, that trait is considered to lack any genetic influence. (
  • In all, the researchers recruited 78 identical-twin pairs and 27 pairs of fraternal twins and drew blood from both members of each twin pair. (
  • California researchers examined 72 pairs of identical twins, who share all of the same genes, and 67 pairs of fraternal twins, who share many but not all genes. (
  • And when the researchers compared individual pairs of identical and fraternal twins, they found that the brains of the right-handed identical siblings were the most similar structurally, suggesting a strong genetic underpinning to right-handedness that does not seem to be present for left-handedness. (
  • As my appointments continued, I learned that pre-term labor is the most common risk of twin pregnancies, both identical and fraternal. (
  • My Fox Boston reported in June 2014 about a pair of fraternal twins who shared a placenta being born 24 days apart. (
  • For example, by modelling phenotypic covariance in identical and fraternal twins and assuming equal sharing of the rearing environment, the classical twin design is able to decompose observed phenotype variation in twins into genetic (additive, dominant) and environmental (common and unique) components, enabling estimation of the genetic contribution to phenotype development or diseases (heritability) without knowledge of the individual genotypes. (
  • While twins that don't look alike are referred to as fraternal twins, identical twins typically look, well, identical. (
  • How are twins made identical or fraternal? (
  • MONDAY, Jan. 14, 2019 (HealthDay News) -- Two of every five common diseases are at least partially influenced by a person's genetics, the largest U.S. study of twins ever conducted finds. (
  • December 4, 2019 - Two lung imaging studies from Robarts Research Institute scientists, including one performed in non-identical twin patients with life-long asthma, have shown that airway defects in the lungs of asthmatic patients are like thumbprints - they have a unique pattern and maintain that pattern over time. (
  • Minnesota Twins' C.J. Cron (24) and Marwin Gonzalez, right, are greeted at the dugout after Cron hit a two-run home run that scored Gonzalez during the first inning of the team's baseball game against the Texas Rangers in Arlington, Texas, Saturday, Aug. 17, 2019. (
  • THURSDAY, OCT. 3, 2019 (HealthDay News) -- No, you're not seeing double as often these days: After decades of rising, twin births are declining in the United States. (
  • The researchers identified more than 56,000 twins and more than 724,000 pairs of siblings. (
  • The team tracked the health of the siblings using insurance records, focusing on a set of 560 diseases that are not rare and affect both men and women, Lakhani said. (
  • The researchers also used ZIP codes in the database to estimate the influence of environmental factors, like socioeconomic status, climate conditions and air quality on disease in the siblings. (
  • In their early descriptions of LCPD, both Jacques Calvé 13 and Georg Perthes 14 described siblings with the disease. (
  • Frederick Miller , chief of the Environmental Autoimmunity Group at the National Institute of Environmental Health Sciences in Bethesda, MD, is spearheading a study of twins and siblings with rheumatoid arthritis, lupus, and scleroderma to determine the specific environmental exposures and genetic factors that contribute to these diseases. (
  • In research announced today at the American College of Cardiology s 53rd Scientific Sessions in New Orleans, the scientists say they found a decrease in heart rate variability (HRV) in those twins who were depressed as compared to their non-depressed siblings. (
  • P-ANCA was found in two of 10 (20%) healthy twin siblings to twins with ulcerative colitis, which was not significantly different from healthy controls (p = 0.18). (
  • There are several families with siblings who have Crohn's but I can't think of any sets of twins. (
  • Our aims were to explore if there is a subclinical inflammation with increased neutrophil activity in healthy twin siblings in discordant twin pairs with IBD and to assess the influence of genetics in this context. (
  • Methods: Nuclear factor kappa B (NF-B) and neutrophil activity, based on myeloperoxidase (MPO) and FC, were analyzed in healthy twin siblings in discordant twin pairs with IBD and compared with healthy controls. (
  • Results: In total, 33 of 34 healthy twin siblings were histologically normal. (
  • The girl's twin sister, two older siblings, aged four and six years and the parents were well at the time of her presentation. (
  • The incidence of two infant twin siblings dying within 24 hours of each other two days after receiving vaccines is factual. (
  • Here, we assessed differential gene expression in MZ discordant twin pairs (affected vs. non-affected) for seven phenotypes, including chronic fatigue syndrome, obesity, ulcerative colitis, major depressive disorder, intermittent allergic rhinitis, physical activity, and intelligence quotient, comparing the spectrum of genes differentially expressed across seven phenotypes individually. (
  • With the recent rapid development in modern biotechnology of high-throughput genetic and genomic analyses, twin modelling is expanding from analysis of diseases to molecular phenotypes in functional genomics especially in epigenetics, a thriving field of research that concerns the environmental regulation of gene expression through DNA methylation, histone modification, microRNA and long non-coding RNA expression, etc. (
  • The application of the twin method to molecular phenotypes offers new opportunities to study the genetic (nature) and environmental (nurture) contributions to epigenetic regulation of gene activity during developmental, ageing and disease processes. (
  • However, when comparing discordant twin pairs in within-twin pair analyses, there was no statistically significant association between birth weight, intrauterine growth, and future risk of CD. (
  • We aimed to test if somatic mutations play a role in CD etiology by sequencing the genomes and exomes of directly affected tissue from the bowel and blood samples of one and the blood-derived exomes of two further monozygotic discordant twin pairs. (
  • Identical twins are identical in genes, but they are not identical in gene expressions, a difference due to epigenetics. (
  • The chromosomes containing these polymorphisms were not the same as the chromosomes containing genes associated with the susceptibility of autoimmune thyroid diseases. (
  • Studying how gene expression differs in identical twins could shed light on how genes and environment interact. (
  • Identical twins share the same set of genes, such as ones for thick eyelashes or a pointy nose - as well as the genes that boost risk for diseases. (
  • New research comparing gene expression in pairs of identical twins in which only one twin has a disease is trying to answer that question, looking at how the environment or other factors interact with genes to increase disease risk. (
  • Holoshitz and his team analyzed gene expression patterns in each duo, looking for genes that were either under- or over-expressed in those with the disease. (
  • It could be that at a certain point in their lifetime, the twin with the disease got epigenetic modifications of certain genes that didn't happen in the healthy twin," says Holoshitz. (
  • It will be important to try to study these genes in greater detail and in other populations, to try to confirm and understand how they play a role in disease," says Lindsey Criswell, a scientist who studies arthritis at the University of California, San Francisco. (
  • Improving gene-sequencing technologies have focused attention on the role of genes in diseases. (
  • However, the two genes have different roles to play in the development of disease, according to their new findings published in the journal Leukaemia . (
  • Genes, environments, and sex : factors of importance in atopic diseases in 7-9-year-old Swedish twins. (
  • The clustering of atopic disease in families was almost entirely due to a common set of genes, but each disease manifestation also seemed to have specific genes of importance. (
  • We estimated the relative importance of genes and environment in dry eye disease (DED) using a classic twin study. (
  • We performed epigenetic inactivation of genes by methylation of CpG islands using genomic DNA from each twin. (
  • In the more affected twin, five methylated including CACNA1A and three demethylated genes were identified at CpG islands (P-value= 0.01-0.001) as well as two methylated genes from enhancer regions (P-value 0.05-0.01). (
  • Even if the twins had identical DNA, the environment (even in the womb) influences how their genes are expressed. (
  • It is likely a combination of genes and environmental factors are responsible for the onset of Alzheimer's disease. (
  • ST. PAUL, Minn.-The Minnesota Department of Natural Resources says testing for chronic wasting disease is finished and no deer were positive for the disease. (
  • What is Chronic Lung disease? (
  • Home AGES & STAGES INFANTS What is Chronic Lung disease? (
  • Both were diagnosed with Chronic Lung Disease. (
  • What is known is that Chronic Lung Disease (sometimes referred to as Bronchopulmonary Dysplasia) is more common in premature babies born before 26 weeks of gestational age and whose birth weight is less than 2.2 lbs. (
  • With us, we were told Chronic Lung Disease is something our twins would likely outgrow. (
  • Some of the most important hypotheses regarding familial aggregation of chronic diseases related to gene-environment interactions which drew on both fields. (
  • Kramer MS . Association between restricted fetal growth and adult chronic disease: is it causal? (
  • Celiac disease (CD) is a chronic immune-mediated disorder triggered by the exposure to gluten in genetically predisposed individuals. (
  • The researchers also looked at how the MRI ventilation defects predict those patients that transition from asthma to chronic obstructive pulmonary disease (COPD), which does not respond to treatments that help open up closed airways. (
  • Echosens, an innovative high-technology company offering the FibroScan family of products, points to the inextricable, well-documented links between asymptomatic non-alcoholic fatty liver disease (NAFLD) -- the most common chronic liver disease in America -- and type 2 diabetes, with 80 percent of people with diabetes having excessive fat in the liver. (
  • Echosens, the developer of FibroScan®, is an innovative high-technology company offering a full range of products and services supporting physicians in their assessment and management of patients with chronic liver diseases. (
  • Because of menorrhagia, a 13-year-old girl was found to have type I von Willebrand disease and then chronic autoimmune thyroiditis with hypothyroidism. (
  • Crohn's disease (CD, OMIM #266600) is a complex, chronic inflammatory bowel disease (IBD) affecting between 0.1-16/100,000 persons worldwide, with a higher incidence in the Western world. (
  • Some patients, about 10-20%, can develop a debilitating chronic condition called post-treatment lyme disease syndrome , with symptoms that include arthritis, fatigue, muscle pain and minor cognitive impairments such as headaches and sleep disturbances. (
  • Early stages of Lyme disease can be effectively treated with antibiotics, but patients with the chronic variant may require months or even years of treatment before it resolves. (
  • Increased blood sugar - Moderate and severe periodontal disease creates a chronic inflammation in the body and release certain chemicals in the body (Cytokines). (
  • Genetic analysis has shown abnormal expansion of CAG repeat in the first exon of the androgen receptor gene on chromosome X different between the twin brothers (44, respectively, 46) but with large phenotypical differences including onset age, evolution, and clinical features. (
  • But this particular strain isn't mad cow disease, said Dr. Jim Lederer, Novant's vice president for clinical development. (
  • We present the case of congenital neonatal lupus erythematosus in non-identical twins, showing variability in clinical manifestation of this disease,despite receiving the same level of antibodies from the mother. (
  • Clinical expression is variable however cardiac manifestations are common, irreversible and often associated with a high mortality.2,3 Early pacemaker implantation in a structurally normal heart may be a lifesaving intervention and should be considered.4 We present a case of congenital NLE with clinical and laboratory differences, showing the discordant clinical spectrum in twins receiving the same level of antibodies from the mother. (
  • She adds that the results of the twin study are important not only because they provide an explanation for how depression increases CHD risk in persons without CHD initially, but also because they underscore the clinical significance of minor depression in addition to major depression. (
  • Professor Peter Braude, head of the department of women's health at King's College and clinical director of the pre-implantation genetic diagnosis (PGD) programme said: "PGD can make an enormous difference for some families who have repeatedly miscarried, lost children through serious genetic disease, or are living with a child suffering from a serious genetic disease. (
  • The innate immune response status correlates with a divergent clinical course in congenital Chagas disease of twins born in a non-endemic country. (
  • The patient, who had no history of heart disease, was hospitalized with clinical symptoms of unstable angina, associated with T-wave negativity on the inferior aspect. (
  • Located in Los Angeles, Huntington Park and Panorama City, CA, National Research Institute has provided free quality medical care to patients with diabetes and performed clinical studies for patients with diabetes, obesity, fatty liver disease and other medical conditions for over 30 years. (
  • All clinical and laboratory evidence of von Willebrand disease resolved transiently after infusion of desmopressin, and permanently with L-thyroxine therapy. (
  • Twin pairs with at least one chart-validated SLE proband were invited to participate in a personal interview and clinical validation of the SLE diagnoses. (
  • OBJECTIVE: To determine the concordance of systemic lupus erythematosus (SLE) and co-aggregating autoimmune diseases among Danish twins. (
  • CONCLUSION: Population-based Danish data suggest that SLE twin concordance is lower than previously reported, but still point to the importance of both genetic and environmental factors, and indicate a substantial co-aggregation of other autoimmune diseases in SLE twins. (
  • Stories of other patients with autoimmune diseases, like Smith, who are deliberately infecting themselves with worms have surfaced. (
  • Monozygotic Twins Discordant for Kennedy Disease: A Case Report. (
  • Brain disorders were most strongly influenced by genetics, the investigators found, with four of five cognitive diseases having a genetic component. (
  • Genetics played at least some role in about 40 percent of the diseases investigated, the researchers determined. (
  • The analysis left a great deal of disease not explained by either genetics or environment, which Patel found "slightly surprising. (
  • The study also focused on children and young adults, which means that genetic factors are more likely to crop up in more diseases since they haven't lived long enough to see cumulative effects from long-term environmental exposures, added Dr. David Flannery, director of telegenetics and digital genetics at Cleveland Clinic's Genomic Medicine Institute. (
  • Experts say that genetics accounts for about 60 percent of the occurrences of the disease, while other factors, such as infections or exposure to toxins, are responsible for the remaining 40 percent. (
  • Twin studies could be helpful in researching the role of genetics in the development of CD. (
  • Increasing evidence suggests that a combination of host genetics and the composition of the gut microbiota are important for development of Crohn's disease (CD). (
  • Our aim was to study identical twins with CD to determine microbial factors independent of host genetics. (
  • Since the final decades of the last century, twin studies have made a remarkable contribution to the genetics of human complex traits and diseases. (
  • Although there can be critical flaws in the assumptions ( Rijsdijk and Sham, 2002 ), the classical twin method has made a remarkable contribution to the literature on human genetics in the past century, especially in the last few decades. (
  • 12/07/2018 - What do hypertension, obesity, smoking and celiac disease have in common? (
  • Twin birth rates had been on the rise for 30 years, but dropped 4% between 2014 and 2018, health officials said in a new U.S. government study. (
  • In 2018, there were 32.6 twins for every 1,000 U.S. births. (
  • Between 2014 and 2018, the number of twins born in the United States dropped about 2% a year, the study found. (
  • Between 2014 and 2018, the data showed significant declines in twin birth rates in 17 states and significant rises in three: Arizona, Oklahoma and Idaho. (
  • In 2018, twin birth rates ranged from 24.9 per 1,000 in New Mexico to 36.4 in Michigan and Connecticut. (
  • Nearly 40 percent of 560 different diseases have a genetic component, while 25 percent are driven by environmental factors shared by twins who are growing up in the same household, the researchers reported. (
  • A new study by researchers at the Osaka University Graduate School of Medicine reports which epigenetic factors in certain chromosomes that make one twin more at risk for autoimmune thyroid diseases. (
  • She adds that because the researchers studied subjects who already developed the disease, it's unclear if the abnormal expression patterns were a consequence of the disease or actually led to its onset. (
  • Depression is a recognized risk factor for coronary heart disease (CHD) and, by studying pairs of twins, researchers from Emory and Yale believe they have found a mechanism that explains this link. (
  • In addition researchers also look at genetic clues for the disease in the mother and father. (
  • I n a case study published today in the journal Chest, the researchers used the same technique in a set of twins with asthma. (
  • While the twins are non-identical, the researchers found that they actually had identical ventilation defects in the same upper left lung segment, which stayed the same over the duration of the seven year study. (
  • Future outbreaks of foot-and-mouth disease can be combatted quickly and efficiently from early on - when authorities have minimal information - thanks to a new real-time strategy, developed by researchers at the University of Warwick. (
  • The researchers are of the opinion that this could be due to increase in vitamin intake after being confirmed of a twin pregnancy. (
  • Though twin birth rates fell by 10% or more for mothers starting at age 30, the decline was greatest among women 40 and older, and it was only seen in white women, the researchers found. (
  • A group of international researchers have found a gene that appears to increase the risk of developing late onset Alzheimer's disease. (
  • Our identical twins Tim and Cary were born 11 weeks early after developing Twin to Twin Transfusion Syndrome (TTTS) where one was getting more blood than the other. (
  • That disease is called Twin-to-Twin Transfusion Syndrome, and this is a story of how terrible it is. (
  • The other twin pregnancy risk is Twin-to-Twin Transfusion Syndrome (TTTS), but its occurrence is more rare, happening only in 10 percent of identical twin pregnancies. (
  • He and his twin brother, Logan, suffered from twin-to-twin transfusion syndrome, a condition marked by a shared placenta in utero. (
  • Gorveatt's birth is rare and the result of twin-to-twin transfusion syndrome, which occurs when blood supply of one twin moves to the other via the babies' shared placenta. (
  • 50 twin to twin transfusion syndrome (ttts) is a rare condition that occurs during a twin pregnancy when blood moves from one twin (the "donor twin") to the other (the "recipient twin") while in the womb. (
  • Twin-to-Twin Transfusion Syndrome, also known as twin to twin transfusion syndrome , is related to renal tubular dysgenesis and acitretin/etretinate embryopathy . (
  • An important gene associated with Twin-to-Twin Transfusion Syndrome is PGF (Placental Growth Factor), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway . (
  • 72 Twin-to-twin transfusion syndrome (TTTS), also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin. (
  • The concept Virus Diseases -- epidemiology -- Africa represents the subject, aboutness, idea or notion of resources found in Twin Lakes Library System . (
  • Her current pregnancy remained uneventful apart from a significant persistent foetal bradycardia detected antenatally at 36 weeks gestation in one of the twins which lead to the delivery by caesarean section of two baby girls. (
  • 1 Individuals with CD are at increased risk of a number of disorders 2 including lymphoproliferative disease 3 and adverse pregnancy outcome, 4 and in most populations also death. (
  • This is stretching it but I've observed a friend of mine who has twin girls - one twin is diabetic and has some limits on her physical activities due to the diabetes (and incidentally just delivered a baby and had a very high risk pregnancy) and the other is very healthy, not diabetic and an athlete. (
  • Crohn's Disease Forum » Pregnancy, Trying to Conceive & Breast Feeding with IBD » Anyone had twins! (
  • I have not had twins, but I did flare during my second pregnancy. (
  • Her tone didn't scare me, but I learned all I could about "experiencing a twin pregnancy" nonetheless. (
  • Human twins are produced when one pregnancy results in two offspring. (
  • She had not received MV vaccination nor been infected with MV. The present pregnancy was complicated with twinning, and cervical cerclage was performed to prevent premature delivery at 14 weeks of gestation. (
  • Folic acid is also known as folate or a form of vitamin B. this vitamin if taken before a pregnancy is said to increase the chances of having a twin baby or to avoid neural tube defect. (
  • The results showed weak relationship between use of multivitamins and folic acid during pregnancy and having twin babies. (
  • The study brings into focus that taking of folic acid before pregnancy does not have an effective result of conceiving twin babies. (
  • Both genetic and environmental factors are involved in the development of coronary disease (CD). (
  • We describe 2 identical twins diagnosed with unstable angina, in both cases with right coronary artery disease, within an interval of 6 months, and both treated percutaneously with placement of a coronary stent. (
  • Objective- Because of lack of evidence, we aimed to examine to what degree low-grade systemic inflammation and coronary heart disease (CHD) death shared common genetic and environmental substrates. (
  • The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease. (
  • Studies in humans have shown that men and women whose birth weights were at the lower end of the normal range, who were thin or short at birth, or who were small in relation to placental size have increased rates of coronary heart disease. (
  • The programming of blood pressure, insulin responses to glucose, cholesterol metabolism, blood coagulation, and hormonal settings are all areas of active research.The BMJ's recent editorial on the fetal origins hypothesis stated that it rests only on the "very general" proposition that fetal undernutrition causes coronary heart disease. (
  • The hypothesis states that coronary heart disease is associated with specific patterns of disproportionate fetal growth that result from fetal undernutrition in middle to late gestation. (
  • The early epidemiological studies that pointed to the possible importance of programming in coronary heart disease were based on the simple strategy of examining men and women in middle and late life whose body measurements at birth were recorded. (
  • Two patients (monozygotic twin brothers) with premature coronary artery disease were reported so as to emphasize and review the importance of known and unknown hereditary risk factors. (
  • These cases, along with the 12 pairs of twins with CAD reported previously, suggest that the asymptomatic twin should be carefully followed-up when the co-twin has documented coronary artery disease. (
  • Raised Hcy levels are present in significant numbers of patients with peripheral, cerebrovascular and coronary heart disease (CHD). (
  • Variations of the gene have also been reported to possibly increase the risk of coronary artery disease. (
  • Studies of twins: what can they tell us about the fetal origins of adult disease? (
  • Morley R , Dwyer T . Fetal origins of adult disease? (
  • fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. (
  • At 32 weeks of gestation, fetal heartbeat of one of the twins was not detected, and the death was confirmed by ultrasonography. (
  • The mother was transferred to our center because of suspected fetal distress of the surviving co-twin. (
  • These findings are important because decreased HRV is a heart disease risk factor," says Emory Heart Center cardiologist Viola Vaccarino MD, Ph.D., lead author of the study. (
  • Discordance for congenital heart disease was observed in the twins: Twin A presented with pulmonary atresia with an intact ventricular septum, critical tricuspid stenosis, and severe right-ventricular hypoplasia, whereas twin B presented with mild mitral valve dysplasia. (
  • They've got the people and they've got the capability and they've got the right focus to deal with valvular heart disease and take a lead in at least the U.S., if not the world. (
  • Valvular heart disease is a public health crisis. (
  • Uncontrolled diabetes has multiple complication including vision loss (retinopathy), stroke, heart disease, circulation and nerve problem in extremities (peripheral vascular disease and neuropathy). (
  • Smoking -The harmful effects of smoking, particularly heart disease and cancer, are well known. (
  • Why might one person get cancer or heart disease and another not - is it their genetic profile, what they ate (or didn't eat), how much (or how little) they exercised or other lifestyle factors? (
  • The model was the famous Framingham Heart Study, a long-term study that initially analyzed 5200 residents of Framingham, Massachusetts, seeking factors that influence heart disease. (
  • P-ANCA was analysed with indirect immunofluorescence technique in 12 monozygotic twin pairs with ulcerative colitis and 14 twin pairs with Crohn's disease. (
  • Furthermore, the study included 21 non-twin patients with ulcerative colitis, 18 non-twin patients with Crohn's disease, and 52 healthy controls matched for sex and age. (
  • The results in Crohn's disease did not differ from healthy controls. (
  • Previous findings of P-ANCA occurring in ulcerative colitis but not in Crohn's disease are supported. (
  • Crohn's disease (CD) is an inflammatory bowel disease caused by genetic and environmental factors. (
  • Eight years ago, New Yorker Herbert Smith did the unthinkable -- he swallowed thousands of pig whipworm eggs in a desperate bid to quell his advancing Crohn's disease. (
  • Smith has been battling Crohn's disease since he was diagnosed as a teenager. (
  • As many as 1.4 million Americans live with Crohn's disease or its cousin, ulcerative colitis, according to the U.S. Centers for Disease Control and Prevention. (
  • In Crohn's disease, the body's immune system mistakenly attacks the lining of the intestine, causing diarrhea, abdominal pain, fatigue, bleeding and infections. (
  • Smith started studying the medical literature on how parasites might be useful in the treatment of inflammatory bowel disorders such as Crohn's disease. (
  • The National Academy of Sciences/National Resource Council (NAS/NRC) World War II (WWII) Veteran Twins Cohort Registry is one of the few population-based groups of elderly twins. (
  • The age- and sex-adjusted point SLE prevalence in the Danish twin cohort was 30.3 per 100,000 persons (95% CI: 19.2-46.5). (
  • Within each pair of twins we studied, HRV parameters were strongly related with the severity of depressive symptoms. (
  • 2, 7, 8 MacGregor et al first assessed the genetic basis of RP in a population based twin study and found a substantial genetic contribution to the symptoms of RP. (
  • When people with celiac disease eat gluten, it triggers an immune reaction, and the inflammation that occurs in the digestive tract may cause a wide variety of signs and symptoms involving many parts of the body. (
  • While celiac disease is very common and affects approximately 1 in 100 people worldwide, it can be difficult to diagnose, especially if a person does not exhibit many of the classic symptoms of the disease," said Dr. Dale Lee , director of Seattle Children's Celiac Disease Program. (
  • Six months after this patient was admitted, his identical twin brother (age 49) was hospitalized with symptoms of progressive angina. (
  • Dry eye disease (DED) is defined as a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability, with potential damage to the ocular surface. (
  • Timely treatment for Lyme disease is crucial to prevent illness and avoid long-lasting symptoms. (
  • Every patient is different and it is important to realize that not everyone develops symptoms as a result of degenerative disc disease. (
  • The most prominent symptoms initially observed in Norrie disease are ocular (affect the eye). (
  • Auditory symptoms (affect the ear) are common with Norrie disease. (
  • Individuals with Norrie disease can also have cognitive and behavioral symptoms. (
  • On the other hand , eye diseases and respiratory disorders were most likely to be influenced by the environment in which twins were raised, the results showed. (
  • He says the study demonstrates the complexity in diagnosing metabolic diseases like thyroid disorders. (
  • In a study reporting extraocular manifestations in 56 patients with Norrie disease, conditions reported included cognitive impairment (28% of patients), behavioral issues, for example autism spectrum disorder (27% of patients presented with autism or autism-like disorders), neurological features, including seizure disorders and epilepsy (16% of patients reported seizures or seizure history), and peripheral vascular disease (38% of patients). (
  • Consistent with this, some case reports of Norrie disease patients have reported the presence of sleep disorders. (
  • A pair of identical female twins with ophthalmic Graves' disease is described. (
  • A pair of identical 20-year-old twins who have always lived as each other's 'shadow' have only a few months left together because one of them has been diagnosed with bone cancer. (
  • A pair of identical twins is developed when one oocyte is fertilized by a single sperm (monozygotic, MZ) and the embryo splits into two, resulting in two genetically identical offspring. (
  • Dr. Cantor explains that in most instances, a pair of identical twins share the same DNA when they split. (
  • NEW YORK (Reuters Health) - A new study of twins bolsters the belief that there may be a gene that distinguishes righties from lefties, and perhaps influences the structure and function of their brains as well. (
  • It could eventually shed light on the factors that trigger the disease in genetically susceptible individuals. (
  • Recent studies have demonstrated genetic differences between monozygotic twins, who were long thought to be genetically completely identical. (
  • Monozygotic (MZ) twins have long served as a model for the influence of environmental factors versus genetic factors ("nature vs. nurture"), since they are believed to be genetically identical. (
  • In the past years it has been repeatedly shown that the assumption of genetically identical monozygotic twins needs to be reconsidered. (
  • The cases presented highlight the occurrence of longer than typically described incubation periods and illustrate the individual variability for progression from infection to disease in genetically related individuals. (
  • In effect, though identical twins don't have identical DNA, they are genetically similar. (
  • The foundation's Valve Science Center was founded in 2016 dedicated to research and education about heart valve disease. (
  • The absolute risk that a co-twin of an affected individual will develop LCPD is low, even in the case of monozygotic twin pairs. (
  • We report a case of monozygotic twins whose mother was infected with measles at 19 weeks' gestation. (
  • We encountered a case of monozygotic twins whose mother was infected with MV at 19 weeks of gestation. (
  • As a multifactorial disease, a variety of genetic and environmental factors play a role in its etiology. (
  • Additionally the data confirm the value of epigenetic events on disease cause as well as phenotypic variation basis among monogenic and multifactorial diseases. (
  • We extracted all twin pairs from the Danish Twin Registry (DTR) in which at least 1 individual had LCPD. (
  • In this study, our purpose was to detect all cases of dementia in an established twin registry and to estimate total extent of genetic contribution to liability to Alzheimer's disease. (
  • To analyze cardiovascular disease mortality and total mortality in the NAS-NRC Twin Registry using a new methodology that allowed for censored observations of outcomes, environmental covariates, and unmeasured genotype-environment interactions. (
  • Using the Swedish Twin Registry, we examined the birth weight of 146,830 twins according to the CD status. (
  • METHODS: SLE-affected twins were ascertained by record linkage between the National Patient Register (NPR) and the Danish Twin Registry (DTR). (
  • Borrelia burgdorferi is a spirochete (corkscrew-shaped bacterium) that consists of more than 20 sub-species, five of which can cause disease in humans. (
  • One advantage of pig whipworms is that they don't cause disease in humans. (
  • Findings indicate a substantial genetic effect for these predominantly late-onset Alzheimer's disease cases. (
  • They found the gene variation by examining the human genomes of 2,269 people with late-onset Alzheimer's disease and 3,107 without the disease. (
  • Identifying this gene is important because the gene is known to be involved in influencing the body's levels of homocysteine, and high levels of homocysteine are a strong risk factor for late-onset Alzheimer's disease,' Dr Pericak-Vance said. (
  • However, food prep takes some careful planning in the Brennan household as both girls are on a strict gluten-free diet to manage celiac disease, an autoimmune disorder that they were diagnosed with in September 2017. (
  • With help from the Celiac Disease Program at Seattle Children's, Claire and Emma learned about ways to control their disease by making specific dietary choices. (
  • Celiac disease is an autoimmune disorder that causes damage in the small intestine. (
  • People with celiac disease respond differently to gluten, a protein found in wheat, rye and barley. (
  • It was also difficult to tell that both Claire and Emma had celiac disease because they seemed to be healthy and thriving. (
  • While the main causes of celiac disease are unknown, people can inherit the risk to develop the disease from a parent. (
  • People with a first-degree relative, such as a parent, child or sibling, with celiac disease also have an increased risk. (
  • Earlier research suggests that birth weight may be associated with celiac disease (CD), but the direction of association has been unclear potentially due to confounding effect from genetic and intrafamilial factors. (
  • Do you have questions about celiac disease or the gluten-free diet? (
  • These days, people with celiac disease make up a small percentage of overall gluten-free food sales. (
  • A new study has found that a childhood stomach bug may be the cause of celiac disease later in life. (
  • In these diseases, the body produces anti-thryoglobulin autoantibodies that cause the immune system to attack the patient. (
  • In the recent study, scientists at the University of Michigan studied 11 pairs of twins in which one member of the pair had rheumatoid arthritis, an auto-immune disease that destroys the tissue lining the joints. (
  • The study, published in CELL , shows that our environment, more than our heredity, plays the starring role in determining the state of our immune system, the body's primary defense against disease. (
  • To find out whether the tremendous differences observed between different people's immune systems reflec tunderlying genetic differences or something else, Davis and his colleagues compared members of twin pairs to one another. (
  • The innate immune response from diamniotic and dichorionic twin brothers congenitally infected with Trypanosoma. (
  • The course of disease depends on the immune status of the host and the specific Leishmania spp. (
  • Data available from two epidemiologic questionnaires administered ten years apart were used to determine the extent to which an increased familial risk in cardiovascular disease mortality among twins was mediated by similarities in behavioral risk factors such as smoking, diet, weight changes, physical activity, and socioeconomic variables. (
  • Because of the liver's central role in so many body processes, fat in the liver can have a ripple effect, increasing the risks of developing both cardiovascular disease and progression of prediabetes to overt disease. (
  • A causal relationship between homocysteine and cardiovascular disease is felt to be highly likely and hyperHcy is now an established modifiable risk factor for cardiovascular disease. (
  • The Greenstreets already have a daughter affected by cystic fibrosis (CF). Pre-implantation genetic haplotyping looks for a genetic 'fingerprint' of diseases such as CF, sickle cell disease, Huntington's disease, Duchenne muscular dystrophy and spinal muscular atrophy. (
  • The Sickle Cell Disease Association of America, Inc. (SCDAA) is a nonprofit organization with the sole purpose of supporting research, education and funding of individuals, families those who are impacted by sickle cell disease. (
  • To advocate for and enhance our membership's ability to improve the quality of health, life and services for individuals, families and communities affected by sickle cell disease and related conditions, while promoting the search for a cure for all people in the world with sickle cell disease. (
  • The Sickle Cell Disease Association of America, Inc. originated in Racine, Wisconsin. (
  • There was a common belief that there was a need for national attention to sickle cell disease. (
  • The name was changed in 1994 to the Sickle Cell Disease Association of America, Inc. Over the course of several years, the organization has grown into over 40 different branches. (
  • Research Public Health Education Professional Health Education Patient Services Community Services Support to Global Organizations and Practitioners The Sickle Cell Disease Association of America, Inc. hosts several events throughout each year. (
  • The Sickle Cell Disease National Convention is held annually during the first weekend of October in Baltimore's Inner Harbor. (
  • Tiki Barber - The former NFL running back has sickle cell disease and does his part educating others. (
  • Devin McCourty and Ryan McCourty - Twins fight Sickle Cell Disease with Tackle Sickle Cell Organization. (
  • Santonio Holmes - Runs benefit for son with sickle cell disease. (
  • Sickle Cell Disease Association of America Inc. "Premium Domain Names at already Discounted Prices - is available for sale! (
  • All twin pregnancies are risky, so it's important to keep your twins monitored," Dr. Keller explained. (
  • ttts is a complication that specifically occurs in identical (monozygotic) twin pregnancies that share the same "egg" sac (monochorionic) that may or may not share the same amniotic sac (monoamniotic). (
  • The research also looked into the effect of folic acid on twin pregnancies. (
  • This corresponded to probandwise concordance rates of 25.0% (95% CI: 7.15-59.1) and 7.7% (95% CI: 1.37-33.3), and pairwise concordance rates of 14.3% (95% CI: 2.57-51.3) and 7.7% (95% CI: 1.37-33.3) among MZ and DZ twins, respectively. (
  • Another four co-twins had other autoimmune disease, corresponding to a probandwise concordance of any autoimmune disease of 50.0% in MZ (95% CI: 21.5-78.5) and 23.1% in DZ twins (95% CI: 8.18-50.3). (
  • Working with the Center for Twin Research at Osaka University, his group found 23 identical twins that were discordant for the production of anti-thyroglobulin autoantibodies and sought to find the genetic and epigenetic causes. (
  • One approach to investigating epigenetic variation has been to evaluate samples from twins. (
  • Besides the classical twin model, the case co-twin design using identical twins discordant for a trait or disease is becoming a popular and powerful design for epigenome-wide association study in linking environmental exposure to differential epigenetic regulation and to disease status while controlling for individual genetic make-up. (
  • It can be expected that novel uses of twin methods in epigenetic studies are going to help with efficiently unravelling the genetic and environmental basis of epigenomics in human complex diseases. (
  • Nonisolated LVNC was identified in twins A and B at 23 weeks' gestation. (
  • One of the twins died in utero at 32 weeks' gestation. (
  • One of the twins died in utero at 32 weeks' gestation, and the mother showed serological findings of persistent MV infection for 4 months after delivery. (
  • High values have also been proven to predict the failure of vascular intervention and more rapid progression of CHD and peripheral vascular disease ( Halazun et al, 2007 ). (
  • Peripheral vascular disease (PVD) has also been associated with Norrie disease. (
  • 2, 3 The most common diseases associated with secondary RP are scleroderma, mixed connective tissue disease, systemic lupus erythematosus, occlusive vascular disease, drug effects, haematological abnormalities, and use of vibrating tools. (
  • There were no concordant monozygotic twin pairs. (
  • There is evidence of Legg-Calvé-Perthes disease clustering within families, but the absence of concordant monozygotic pairs in this study suggests that the cause(s) of Legg-Calvé-Perthes disease may occur in utero or in the early childhood environment. (
  • Fecal samples were studied from 10 monozygotic twin pairs with CD (discordant n=6 and concordant n=4) and 8 healthy twin pairs. (
  • A pair of monozygotic twins concordant for Parkinson's disease are described. (
  • Neonatal manifestations of this multisystem disease may include congenital heart block, cutaneous lesions and haematological abnormalities. (
  • The slowly progressing hearing loss is more problematic to adjust to than the congenital blindness for most people with Norrie disease. (
  • We can analyze the individual differences in sensitivity to environmental factors using monozygotic twins. (
  • We present a thorough genetic characterization of the sequenced individuals but detected no consistent differences within the twin pairs. (
  • Genetic differences have been discovered between monozygotic twins [ 9 ], which can be regarded as an extreme form of somatic mosaicism, describing the presence of two populations of cells with different genotypes having developed from a single fertilized egg as a result of postzygotic alterations of the genome [ 10 ]. (
  • However, she continues, a recent report found that some developing twin embryos may already have genetic differences. (
  • This study conducted in Iceland looked at almost 400 sets of identical twins, finding that 12% of the identical twins they examined had up to 100 genetic differences. (
  • There can be differences between the twins because of the interactions in how the environment interacts with their genetic material. (
  • They were able to identify differences in the genetic sequences of the MTHFD1L gene in people with and without Alzheimer's disease. (
  • We present what is to our knowledge the first prenatal diagnosis of LVNC in monochorionic-monozygotic twins. (
  • The diagnosis of MND was verified via the co-twin and relatives, and medical records where available. (
  • In wondering if there are any other sets of twins out there who have the same diagnosis? (
  • Visceral leishmaniasis is an important differential diagnosis for fever of unknown origin and pancytopenia in young children living in countries with endemic disease and highlights the importance of obtaining a detailed travel history. (
  • An SLE diagnosis was clinically validated in 17 twins from 15 twin pairs. (
  • When Lyme disease is suspected, laboratory tests to detect specific antibodies against Borrelia burgdorferi can help confirm the diagnosis - although these are far from perfect . (
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (
  • The diagnosis of degenerative disc disease comprises of complete medical history and physical examination. (
  • It's a natural disease of the placenta that affects both babies. (
  • It has also been suggested that Lyme disease could be transferred to a foetus via the placenta, however this has yet to be proven. (
  • This case is informative in the following respects: the villous trophoblasts had diagnostic inclusion bodies and ultrastructural evidence of measles virus infection, the degree of viral involvement within the monochorionic placenta was uneven, both of the twins were virtually free from measles virus infection despite the marked involvement of the placenta, and measles virus infection had persisted in the monochorionic placenta for approximately 13 weeks. (
  • We present the clinicopathological findings of the monozygotic twins and the mother and describe the significance of histopathologic examination of the placenta. (
  • Because both types of twins share the same in utero environment and, usually, pretty close to the same childhood environment as well, they make great subjects for contrasting hereditary versus environmental influence. (
  • The scientists studied 50 pairs of male twins between the ages of 47 and 57 who were free of symptomatic CHD. (
  • This population-based study found that in male twins, higher birth weight was associated with higher risk of CD. (
  • Approach and Results- From the 41-year prospective National Heart, Lung, and Blood Institute Twin Study, we included 950 middle-aged male twins at baseline (1969-1973). (
  • Slidell twin brothers were diagnosed with liver disease. (
  • Type 2 Diabetes and Liver Disease: Twin Epidemics Call fo. (
  • When you get fatty liver disease, diabetes may be more difficult to control. (
  • Losing weight plays a critical role in the prevention and treatment of type 2 diabetes and fatty liver disease. (
  • Conversely, obesity is responsible for causing about 85 percent of fatty liver disease. (
  • Many diseases are caused by a combination of environmental and genetic factors. (
  • Parkinson's disease (PD) is a growing health problem in the elderly, and genetic factors may provide substantial clues toward eventual treatment and/or prevention of the disorder. (
  • The issue of genetic factors in Parkinson's disease is discussed. (
  • Marian and Michelle - so-called omphalopagus twins who were connected at the abdomen - are actually triplets: Sister Tamar was born separately and is healthy. (
  • Regularly monitoring women who are pregnant with twins or triplets, to spot any possible complications, can lead to better outcomes for mothers and their babies, as highlighted in NICE's impact report. (
  • It used to be that several embryos were implanted, leading to the surge in twins and triplets. (
  • That, and the fact she was carrying twins, may have been risk factors, according to Druzin, who did not treat Cottam. (
  • The purpose of the 'Twins and the Risk of PD' study is to follow-up previous studies and confirm the initial findings. (
  • Age and Sjögren's disease are well-known risk factors, and women are at increased risk compared to men. (
  • One twin loses blood and is born smaller, while the other one gains it and stands the risk of suffering cardiac failure due to high blood volume, according to the National Institutes of Health (NIH). (
  • the recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. (
  • Factors determining progression from infection to disease are not fully understood but younger age seems to be an important risk factor. (
  • Blood vessel thickening - Thickening of blood vessels is a complication of diabetes that may increase risk for gum disease. (
  • If you are a smoker with diabetes, age 45 or older, you are 20 times more likely than a person without these risk factors to get severe gum disease. (
  • The dentist will use medical history, family history and dental X-rays to assess the risk factors for periodontal disease and determine the exact condition of the gums, teeth and underlying jawbone. (
  • Legionnaires' disease is usually thought of as a public health issue rather than an occupational health matter, even though it often strikes workers in places at high risk of outbreak (which include cooling towers, premises where mist machines are present, biological waste water treatment facilities, carwash plants, healthcare facilities, spas and hotels). (
  • Do most identical twins have the same risk for different diseases? (
  • The UKB was announced in the early 2000s as a classical epidemiological study-the kind used to associate risk factors such as diet and smoking with the development of disease over time. (
  • Following the severe acute respiratory syndrome (SARS) outbreak in 2003, China stepped up its prevention and control methods for all infectious diseases, and rates of infection have levelled off since 2009. (
  • OBJECTIVES: To investigate the cause of sporadic motor neuron disease (MND) by twin study, so allowing (1) estimation of the genetic contribution, and (2) collection of matched pairs for a case-control study of possible environmental factors. (
  • P-ANCA in monozygotic twins with inflammatory bowel disease. (
  • This study analysed P-ANCA in monozygotic twins with inflammatory bowel disease to evaluate this hypothesis further. (
  • Background: The mechanisms behind increased fecal calprotectin (FC) in healthy relatives of patients with inflammatory bowel disease (IBD) are unknown. (
  • Aida's premature delivery, when she was in her mid-40s, was extremely risky, and their separation surgery carried a 30 percent chance of death for either or both twins. (