Fournier Gangrene: An acute necrotic infection of the SCROTUM; PENIS; or PERINEUM. It is characterized by scrotum pain and redness with rapid progression to gangrene and sloughing of tissue. Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease.Gangrene: Death and putrefaction of tissue usually due to a loss of blood supply.Gas Gangrene: A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.Penile Diseases: Pathological processes involving the PENIS or its component tissues.Toes: Any one of five terminal digits of the vertebrate FOOT.Amputation: The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)Clostridium perfringens: The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.Scrotum: A cutaneous pouch of skin containing the testicles and spermatic cords.Debridement: The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed)Clostridium septicum: A species of gram-positive bacteria in the family Clostridiaceae. Infections have a strong association with malignancies and also with GAS GANGRENE.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Dictionaries, ChemicalFasciitis: Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.Fasciitis, Necrotizing: A fulminating bacterial infection of the deep layers of the skin and FASCIA. It can be caused by many different organisms, with STREPTOCOCCUS PYOGENES being the most common.Communicable DiseasesFamily Practice: A medical specialty concerned with the provision of continuing, comprehensive primary health care for the entire family.Practice Guidelines as Topic: Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.Infectious Disease Medicine: A branch of internal medicine concerned with the diagnosis and treatment of INFECTIOUS DISEASES.Physician's Practice Patterns: Patterns of practice related to diagnosis and treatment as especially influenced by cost of the service requested and provided.United StatesInternational Cooperation: The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.Rare Diseases: A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.Orphan Drug Production: Production of drugs or biologicals which are unlikely to be manufactured by private industry unless special incentives are provided by others.Drug Repositioning: The deliberate and methodical practice of finding new applications for existing drugs.Waiting Lists: Prospective patient listings for appointments or treatments.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Lymphangioleiomyomatosis: A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).Lithiasis: A condition characterized by the formation of CALCULI and concretions in the hollow organs or ducts of the body. They occur most often in the gallbladder, kidney, and lower urinary tract.Fat Body: A nutritional reservoir of fatty tissue found mainly in insects and amphibians.
  • Fournier gangrene was first identified in 1883, when the French venereologist Jean Alfred Fournier described a series in which 5 previously healthy young men suffered from a rapidly progressive gangrene of the penis and scrotum without apparent cause. (medscape.com)
  • However, the disease was named after Jean-Alfred Fournier, a Parisian venereologist, on the basis of a transcript from an 1883 clinical lecture in which Fournier presented a case of perineal gangrene in an otherwise healthy young man, adding this to a compiled series of 4 additional cases. (medscape.com)
  • The pathology was first described in 1883 by Jean Alfred Fournier who presented five male diabetic patients with fulminating gangrene of the genitalia [ 4 ]. (biomedcentral.com)
  • Fournier gangrene destroys infected genital tissue after quickly spreading between the genitals and posterior, according to the FDA, which called it "extremely rare but life-threatening. (usatoday.com)
  • The FDA warned last year about symptoms of the disease, including "tenderness, redness, or swelling of the genitals or the area from the genitals back to the rectum," as well as a fever exceeding 100.4 degrees Fahrenheit and "a general feeling of being unwell. (fox13now.com)
  • In August 2018, the FDA issued a warning to patients and their doctors that some patients who are treated with SGLT2i drugs developed a rare but rapidly progressing form of gangrene that attacks the perianal, genital, or perineal areas of the body. (ifspb.com)
  • In August 2018, the FDA required that the risk of gangrene be added to the information patients receive when prescribed the drugs. (webmd.com)
  • For commercial re-use, please contact [email protected] Downloaded from https://academic.oup.com/omcr/article-abstract/2018/2/omx094/4846369 by Ed 'DeepDyve' Gillespie user on 16 March 2018 Fournier gangrene 49 bacteria. (deepdyve.com)
  • Elisabeth Björk, Senior Vice President, Head of Late-stage Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, said: "Heart failure and renal diseases are two of the most common and early complications experienced by people living with type 2 diabetes, and are too often overlooked. (astrazeneca-us.com)
  • The most serious effects of blood sugar swings are a higher risk for diabetes-related health complications such as stroke , heart disease , and nerve damage (neuropathy) . (everydayhealth.com)
  • Smoking, drinking alcohol, and using intravenous drugs may also add to your risk of developing gangrene. (healthline.com)
  • [ 6 ] He differentiated these cases from perineal gangrene associated with diabetes, alcoholism, or known urogenital trauma, although these are currently recognized risk factors for the perineal gangrene now associated with his name. (medscape.com)
  • This manuscript outlining Fournier's initial series of fulminant perineal gangrene provides a fascinating insight into both the societal background and the practice of medicine at the time. (medscape.com)
  • In anecdotes, Fournier described recognized causes of perineal gangrene, including placement of a mistress' ring around the phallus, ligation of the prepuce (used in an attempt to control enuresis or as an attempted birth control technique practiced by an adulterous man to avoid impregnating his married lover), placement of foreign bodies such as beans within the urethra, and excessive intercourse in diabetic and alcoholic persons. (medscape.com)
  • Thought you might appreciate this item(s) I saw at Infectious Diseases in Clinical Practice. (lww.com)
  • Infectious Diseases in Clinical Practice. (lww.com)
  • There are approximately 7,000 rare diseases (RD). Rare diseases include, some very rare infectious diseases, rare forms of autoimmune disorders, and rare cancers. (disabled-world.com)
  • Students attending the first school year (baseline) had a lesser knowledge of body art related infectious diseases, were less likely to refer to a certified body art parlour, and to know the mandatory hygienic rules to be observed when performing body modifications. (biomedcentral.com)
  • Infectious Diseases and Diabetes is a topic covered in the Johns Hopkins Diabetes Guide . (hopkinsguides.com)
  • Johns Hopkins Guide , www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547072/all/Infectious_Diseases_and_Diabetes. (hopkinsguides.com)
  • Auwaerter P. Infectious Diseases and Diabetes. (hopkinsguides.com)
  • Empirical antimicrobial therapy for pediatric diarrhea in a high-usage, high-resistance setting provided no clinical benefit, and it even prolonged hospital stays in some groups, researchers reported yesterday in Clinical Infectious Diseases . (umn.edu)
  • 1-3 The features of these aggressive infections include extensive pain, rapidly spreading necrosis leading to gangrene of the skin, and underlying sterile structures. (uspharmacist.com)
  • In acute appendicitis , areas of gangrene may occur in the walls of the appendix with consequent rupture through a gangrenous area. (thefreedictionary.com)
  • In older men, nonsexually transmitted acute epididymitis is also associated with prostate biopsy, urinary tract instrumentation or surgery, systemic disease, and/or immunosuppression. (cdc.gov)
  • Men are affected 10 times more often than women, but the disease itself is very uncommon in either sex, and only about 600 cases have been reported in literature in the past 10 years. (patriotledger.com)
  • MONDAY, May 6, 2019 (HealthDay News) -- Say you have type 2 diabetes and you are taking a newer class of medications to treat your disease -- but one day you notice pain, redness and a foul odor in your genital area. (hon.ch)
  • Fournier gangrene occurred in 55 people taking these drugs between March 2013 and January 2019. (hon.ch)
  • FRIDAY, May 31, 2019 (HealthDay News) -- Positive cultural beliefs around taking aspirin for prevention of cardiovascular disease (CVD) are associated with greater adoption of the intervention among African-Americans, according to a study published in the June issue of the Journal of Community Health . (doctorslounge.com)
  • FRIDAY, May 31, 2019 (HealthDay News) -- The rate of emergency department visits with opioids only given during the visit is higher than the rate for visits with opioids only prescribed at discharge and for visits with opioids given and prescribed, according to a May data brief published by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics. (doctorslounge.com)