An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).
Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)
Inorganic salts of phosphoric acid that contain two phosphate groups.
Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable.
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
General disorders of the sclera or white of the eye. They may include anatomic, embryologic, degenerative, or pigmentation defects.
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.
Membrane proteins that are involved in the active transport of phosphate.
Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.
A group of enzymes within the class EC 3.6.1.- that catalyze the hydrolysis of diphosphate bonds, chiefly in nucleoside di- and triphosphates. They may liberate either a mono- or diphosphate. EC 3.6.1.-.
An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
Pathologic deposition of calcium salts in tissues.
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.
The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
A group of compounds with the general formula M10(PO4)6(OH)2, where M is barium, strontium, or calcium. The compounds are the principal mineral in phosphorite deposits, biological tissue, human bones, and teeth. They are also used as an anticaking agent and polymer catalysts. (Grant & Hackh's Chemical Dictionary, 5th ed)
A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.
Phosphoric or pyrophosphoric acid esters of polyisoprenoids.
The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular.
The articulation between a metacarpal bone and a phalanx.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
Fibrocartilage that makes up the triangular fibrocartilage complex which is found in the WRIST JOINT.
A moon-shaped carpal bone which is located between the SCAPHOID BONE and TRIQUETRUM BONE.
The joint that is formed by the distal end of the RADIUS, the articular disc of the distal radioulnar joint, and the proximal row of CARPAL BONES; (SCAPHOID BONE; LUNATE BONE; triquetral bone).
Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
An enzyme that catalyzes the conversion of urate and unidentified products. It is a copper protein. The initial products decompose to form allantoin. EC 1.7.3.3.
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
A heterogeneous group of autosomally inherited COLLAGEN DISEASES caused by defects in the synthesis or structure of FIBRILLAR COLLAGEN. There are numerous subtypes: classical, hypermobility, vascular, and others. Common clinical features include hyperextensible skin and joints, skin fragility and reduced wound healing capability.
An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.
A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.
A medical specialty concerned with the use of physical agents, mechanical apparatus, and manipulation in rehabilitating physically diseased or injured patients.
The act or practice of literary composition, the occupation of writer, or producing or engaging in literary work as a profession.
Restoration of human functions to the maximum degree possible in a person or persons suffering from disease or injury.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
2005). "The ANKH gene and familial calcium pyrophosphate dihydrate deposition disease". Joint Bone Spine. 71 (5): 365-8. doi: ... 1999). "Refinement of the chromosome 5p locus for familial calcium pyrophosphate dihydrate deposition disease". Am. J. Hum. ... Williams CJ (2003). "Familial calcium pyrophosphate dihydrate deposition disease and the ANKH gene". Current Opinion in ... "Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane ...
Rothschild, Bruce M Calcium Pyrophosphate Deposition Disease (radiology) Hubert, Jan; Weiser, Lukas; Hischke, Sandra; Uhlig, ... Another common cause of chondrocalcinosis is calcium pyrophosphate dihydrate crystal deposition disease (CPPD). CPPD is ... "Clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition (CPPD) disease". UpToDate. This topic last ... Wright GD, Doherty M (1997). "Calcium pyrophosphate crystal deposition is not always 'wear and tear' or aging". Ann. Rheum. Dis ...
Calcium pyrophosphate crystals are seen in pseudogout (also known as calcium pyrophosphate deposition disease or, CPPD). These ... Crystals include monosodium urate, calcium pyrophosphate, hydroxyapatite and corticosteroid crystals. Monosodium urate crystals ... and Disease". Systems Biology and Medicine. Wiley Interdisciplinary Reviews. 4 (1): 15-7. doi:10.1002/wsbm.157. PMC 3593048. ... including Lyme disease Acute crystal synovitis (gout) Septic (Group III) Pyogenic bacterial infection Septic arthritis ...
Sodium pyrophosphate Calcium pyrophosphate dihydrate deposition disease Dimethylallyl pyrophosphate ADP ATP Ortho acids ... It is best prepared by ion exchange from sodium pyrophosphate or by treating lead pyrophosphate with hydrogen sulfide. It is ... Anions, salts, and esters of pyrophosphoric acid are called pyrophosphates. ... except that it is a component of polyphosphoric acid and the conjugate acid of the pyrophosphate anion. ...
In some cases, a build-up of calcium pyrophosphate dihydrate (CPPD) crystals in the joint can cause pseudogout. Perinatal and ... a pyrophosphate synthetic analog) in one infant had no discernible effect on the skeleton, and the infant's disease progressed ... Some patients suffer from calcium pyrophosphate dihydrate crystal depositions with occasional attacks of arthritis (pseudogout ... features of pyrophosphate arthropathy, and calcific periarthritis. Odontohypophosphatasia is present when dental disease is the ...
... is a rheumatological condition similar to calcium pyrophosphate dihydrate deposition disease (CPPD). It is associated with ... Along with symptomatology, the disease typically presents with positive radiologic findings, often showing marked erosion of ...
skeletal: arthritis, from calcium pyrophosphate deposition in joints leading to joint pains. The most commonly affected joints ... liver disease, kidney disease, and cancer. Also, total iron binding capacity may be low, but can also be normal. In males and ... In theory, the disease initially evolved from travelers migrating from the north. Surveys show a particular distribution ... Men have a 24-fold increased rate of iron-overload disease compared with women. Diet and the environment are thought to have ...
... protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease". ... Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The ... 2007). "Phenotypic and population differences in the association between CILP and lumbar disc disease". J. Med. Genet. 44 (4): ... is associated with susceptibility to lumbar disc disease". Nat. Genet. 37 (6): 607-12. doi:10.1038/ng1557. PMID 15864306. Mori ...
... may refer to: Calcium pyrophosphate dihydrate crystal deposition disease Certified Practising Project Director This ...
When monoarthritis is caused by pseudogout (calcium pyrophosphate deposition disease, CPPD), the inflammation usually lasts ... Osteoarthritis is a degenerative disease commonly involving the knees and hips. It results from erosion of the cartilage ...
... there is a less common form of gout that is caused by the formation of rhomboidal-shaped crystals of calcium pyrophosphate. ... Other forms of arthritis are rheumatoid arthritis and psoriatic arthritis, which are autoimmune diseases in which the body is ... The most common form of arthritis, osteoarthritis (also known as degenerative joint disease), occurs following trauma to the ...
I. Normal values in osteoarthritis and calcium pyrophosphate dihydrate crystal deposition disease". Arthritis Rheum. 22 (8): ... Chi, Andrew; Kemp, Robert G. (2000). "The Primordial High Energy Compound: ATP or Inorganic Pyrophosphate?". The Journal of ... Rodriguez L & Orgel LE (1991). "Pyrophosphate formation as the most efficient condensation reaction of activated nucleotides". ... Ryan LM, Kozin F, McCarty DJ (1979). "Quantification of human plasma inorganic pyrophosphate. ...
ATPase ATP hydrolysis ATP synthase Biochemistry Bone Calcium pyrophosphate Calcium pyrophosphate dihydrate deposition disease ... I. Normal values in osteoarthritis and calcium pyrophosphate dihydrate crystal deposition disease". Arthritis Rheum. 22 (8): ... Important salts include disodium pyrophosphate and tetrasodium pyrophosphate. The pyrophosphate bond is also sometimes referred ... Pyrophosphate is the first member of an entire series of polyphosphates. The term pyrophosphate is also the name of esters ...
In both the pyrophosphates are essentially eclipsed. Calcium Pyrophosphate Deposition Disease at eMedicine Ropp, R.C. (2013). " ... Calcium pyrophosphate (Ca2P2O7) is a chemical compound, an insoluble calcium salt containing the pyrophosphate anion. There are ... "Calcium pyrophosphate crystal deposition disease: Preparation and characterization of crystals". Journal of Crystal Growth. 87 ... dihydrate crystals in cartilage are responsible for the severe joint pain in cases of calcium pyrophosphate deposition disease ...
The danger molecule can be extracellular ATP, extracellular glucose, crystals of monosodium urate (MSU), calcium pyrophosphate ... Chen G, Shaw MH, Kim YG, Nuñez G (2009). "NOD-like receptors: role in innate immunity and inflammatory disease". Annu Rev ... Their homologs have been discovered in many different animal species (APAF1) and also in the plant kingdom (disease-resistance ... Mutations in NOD2 are associated with Crohn's disease or Blau syndrome. NOD1 and NOD2 recognize peptidoglycan motifs from ...
Bruce M Calcium Pyrophosphate Deposition Disease (radiology) Rothschild, Bruce M Calcium Pyrophosphate Deposition Disease ( ... Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a ... "Calcium Pyrophosphate Dihydrate Deposition Disease: Synovial Biopsy, Wrist". Rheumatology Image Bank. American College of ... "Clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition (CPPD) disease". UpToDate. This topic last ...
Without pyrophosphate, calcium phosphate crystals cannot be broken down. Since the inactive CD73 is unable to produce adenosine ... MacDougall, R. National Human Genome Research Institute, NIH Undiagnosed Diseases Program. (2011). NIH researchers identify ... The calcification of cells is caused in part by a lack of pyrophosphate, which is broken down throughout the body by tissue- ... Arterial calcification due to deficiency of CD73 (ACDC) is a rare genetic disorder that causes calcium buildup in the arteries ...
... such as uric acid or calcium pyrophosphate dihydrate ram crystals found in gout or pseudogout. An X-ray is useful to verify ... There could also be an underlying disease or condition. The type of fluid that accumulates around the knee depends on the ... If blood tests reveal Lyme disease antibodies forming, the condition may be attributed to it. Treatment of fluid in the knee ... Underlying diseases may include Knee osteoarthritis Rheumatoid arthritis Infection Gout Pseudogout Prepatellar bursitis ( ...
Calcium phosphate Calcium oxalate monohydrate Calcium oxalate dihydrate Calcium pyrophosphate Calcium pyrophosphate dihydrate ... Renal diseases are also common in crystallopathies, including: Acute oxalate nephropathy Acute phosphate nephropathy Chronic ... Crystallopathy is a harmful state or disease associated with the formation and aggregation of crystals in tissues or cavities, ... β IgG Elicits a Dual Effect on Calcium Oxalate Crystallization and Progressive Nephrocalcinosis-Related Chronic Kidney Disease ...
Therefore, ADCY2 is highly regulated by G-proteins, calcium, calmodulin, pyrophosphate, and post-translational modifications. ... precocious puberty in males and chondrodysplasia punctata diseases. During these diseases, ADCY2 undergoes a super-related ... "Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and ... in adenylyl cyclase activity have been implicated in alcohol and opioid addiction and is associated with human diseases, ...
Bruce M Calcium Pyrophosphate Deposition Disease (radiology) *^ a b c d e f g h i j k l m n Rothschild, Bruce M Calcium ... Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a ... Calcium pyrophosphate dihydrate crystal deposition disease. From Wikipedia, the free encyclopedia. (Redirected from Calcium ... "Calcium Pyrophosphate Dihydrate Deposition Disease: Synovial Biopsy, Wrist". Rheumatology Image Bank. American College of ...
In pseudogout/chondrocalcinosis/calcium pyrophosphate deposition disease, the crystal is calcium pyrophosphate. Diabetic ... An arthropathy is a disease of a joint. Joint pain is a common but non-specific sign of joint disease. Signs will depend on the ... "Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease-modifying ... Joint diseases can be classified as follows: Arthritis Infectious arthritis Septic arthritis (infectious) Tuberculosis ...
There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known ... Lyme disease Sjögren's disease Hashimoto's thyroiditis Celiac disease Non-celiac gluten sensitivity Inflammatory bowel disease ... Arthritis is predominantly a disease of the elderly, but children can also be affected by the disease. Arthritis is more common ... "Arthritis Risk Factors". Centers for Disease Control and Prevention. Centers for Disease Control and Prevention. Retrieved 22 ...
It is typically used by patients who have excess calcium in their arteries due to kidney disease. In recent years, STS has also ... leading to decreased inorganic pyrophosphate (PPi). This is a potent inhibitor of calcium deposition in the vessel wall. These ... This is due to calcium continuing to build up in the artery walls. If blood flow becomes restricted it can become life ... This is thought to represent mineralization, or small deposits of calcium hydroxyapatite, in the muscle of the heart. EIFs are ...
These include Siberian plague, Cumberland disease, charbon, splenic fever, malignant edema, woolsorter's disease, and even la ... Adenylate cyclase catalyzes the conversion of ATP into cyclic AMP (cAMP) and pyrophosphate. The complexation of adenylate ... cyclase with calmodulin removes calmodulin from stimulating calcium-triggered signaling, thus inhibiting the immune response. ... If the disease is fatal to the person's body, though, its mass of anthrax bacilli becomes a potential source of infection to ...
NaGly was shown to be endogenous ligand for the G-protein couple receptor GPR92 along with farnesyl pyrophosphate. In the ... Understanding functions of NaGly in such structures provides a promising future in helping treat diseases such as endometriosis ... NaGly was identified as a novel insulin secretagogue and was shown to increase intracellular calcium concentration through ... "Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92". The Journal of Biological ...
... the former causing more severe forms of the disease. Alkaline phosphatase allows for mineralization of calcium and phosphorus ... TNSALP enzyme and allows for an accumulation of chemicals such as inorganic pyrophosphate to indirectly cause elevated calcium ...
... and treatment of corticosteroid-associated osteoporosis together with supplements of calcium and vitamin D Paget's disease ... But while pyrophosphate inhibits both osteoclastic bone resorption and the mineralization of the bone newly formed by ... Paget's disease: 40 mg daily for 6 months. The risk of esophageal irritation places special requirements on how this oral drug ... For optimal action, enough calcium and vitamin D are needed in the body in order to promote normal bone development. ...
A pyrophosphate ion with 99mTc adheres to calcium deposits in damaged heart muscle, making it useful to gauge damage after a ... to evaluate coronary artery disease, valvular heart disease, congenital heart diseases, cardiomyopathy, and other cardiac ... Myocardial perfusion imaging (MPI) is a form of functional cardiac imaging, used for the diagnosis of ischemic heart disease. ... which is a low-exposure X-ray test measuring bone density to look for osteoporosis and other diseases where bones lose mass ...
... is a treatment for some types of maple syrup urine disease and Leigh disease.[1] ... Calcium and magnesium have been shown to affect the distribution of thiamine in the body and magnesium deficiency has been ... The synthesis of thiamine diphosphate (ThDP), also known as thiamine pyrophosphate (TPP) or cocarboxylase, is catalyzed by an ... Constable PD, Hinchcliff KW, Done SH, Gruenberg W (2017). Diseases of the Nervous System - Veterinary Medicine (Eleventh ...
Symptoms of this disease of the nervous system include weight loss, emotional disturbances, Wernicke encephalopathy (impaired ... Its active form is a coenzyme called thiamine pyrophosphate (TPP), which takes part in the conversion of pyruvate to acetyl ... It is most likely to occur among elderly people, as absorption through the gut declines with age; the autoimmune disease ... Several named vitamin deficiency diseases may result from the lack of sufficient B vitamins. Deficiencies of other B vitamins ...
Other diseases[edit]. A meta-analysis of 2007 concluded that daily intake of 1000 to 2000 IU per day of vitamin D3 could reduce ... DRIs for Calcium and Vitamin D Archived 2010-12-24 at the Wayback Machine ... Coulston AM, Boushey C, Ferruzzi M (2013). Nutrition in the Prevention and Treatment of Disease. Academic Press. p. 818. ISBN ... This is important for maintaining calcium levels and promoting bone health and development.[8] As a medication, cholecalciferol ...
DiseasesEdit. One thousand mutations have been identified in 12 out of more than 20 types of collagen. These mutations can lead ... Gradual calcium deposition within collagen occurs as a natural function of aging. Calcified points within collagen matrices ... "Binding of Phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography" ... An autoimmune disease such as lupus erythematosus or rheumatoid arthritis[34] may attack healthy collagen fibers. ...
2,0 2,1 2,2 2,3 2,4 2,5 Belenky P; Bogan KL, Brenner C «NAD+ metabolism in health and disease» (PDF). Trends Biochem. Sci., 32 ... Guse AH «Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR)». Curr. Mol. Med., 4 ... Kornberg, A. «The participation of inorganic pyrophosphate in the reversible enzymatic synthesis of diphosphopyridine ... Swerdlow RH «Is NADH effective in the treatment of Parkinson's disease?». Drugs Aging, 13, 4, 1998, pàg. 263-8. DOI: 10.2165/ ...
... which is involved in triggering calcium signals by the release of calcium from intracellular stores.[24] This form of signal ... Lohmann, K. (August 1929). "Über die Pyrophosphatfraktion im Muskel" [On the pyrophosphate fraction in muscle]. ... "Mammalian ABC transporters in health and disease" (PDF). Annual Review of Biochemistry. 71: 537-592. doi:10.1146/annurev. ... or pyrophosphate (PPi) unit from ATP at standard state of 1 M are:[13] ...
This works to alter the calcium sensitivity of the neuron by allowing mutant RETGC-1 to be activated by GCAP at higher calcium ... to other brain regions and has been explored as a possible candidate for restoring striatal dysfunction in Parkinson's disease ... and pyrophosphate: *. ... Also, calcium is linked to apoptosis by causing the release of ... this mutation causes extremely high intracellular calcium levels. Calcium, which plays many roles in the cell and is tightly ...
... immune-mediated diseases and airways disease". Immunology. 148 (1): 1-12. doi:10.1111/imm.12582. PMC 4819138. PMID 26778581.. ... which induces the release of calcium into the cytosol. Low calcium in the endoplasmic reticulum causes STIM1 clustering on the ... The most common phosphoantigens from animal and human cells (including cancer cells) are isopentenyl pyrophosphate (IPP) and ... Asthma and other allergic diseases Th17. IL-17. RORγt. Defense against gut pathogens and at mucosal barriers. Rheumatoid ...
Esta molécula actúa na sinalización de calcio liberando calcio das reservas intracelulares.[59] Isto realízao uníndose e ... Swerdlow RH (1998). "Is NADH effective in the treatment of Parkinson's disease?". Drugs Aging 13 (4): 263-8. PMID 9805207. doi: ... "The participation of inorganic pyrophosphate in the reversible enzymatic synthesis of diphosphopyridine nucleotide" (PDF). J. ... Guse AH (2004). "Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR)". Curr. Mol. ...
Galli C, Risé P (2009). "Fish consumption, omega 3 fatty acids and cardiovascular disease. The science and the clinical trials ... Klein C, Malviya AN (January 2008). "Mechanism of nuclear calcium signaling by inositol 1,4,5-trisphosphate produced in the ... modification of isoprene units donated from the reactive precursors isopentenyl pyrophosphate and dimethylallyl pyrophosphate.[ ... Dalainas I, Ioannou HP (April 2008). "The role of trans fatty acids in atherosclerosis, cardiovascular disease and infant ...
In nature, limonene is formed from geranyl pyrophosphate, via cyclization of a neryl carbocation or its equivalent as shown.[8] ...
Other disease[edit]. A meta-analysis of 2007 concluded that daily intake of 1000 to 2000 IU per day of vitamin D3 could reduce ... The LD50 is 16.8 mg/kg, but only 9.8 mg/kg if calcium carbonate is added to the bait.[34][35] ... Coulston, Ann M.; Boushey, Carol; Ferruzzi, Mario (2013). Nutrition in the Prevention and Treatment of Disease. Academic Press ... This is important for maintaining calcium levels and promoting bone health and development.[7] As a medication, cholecalciferol ...
Gilbert F (1998). "Disease genes and chromosomes: disease maps of the human genome. Chromosome 17". Genet Test. 2 (4): 357-81. ... PRPSAP2: encoding protein Phosphoribosyl pyrophosphate synthetase-associated protein 2. *QRICH2: encoding protein Glutamine- ... CANT1: Calcium-activated nucleotidase 1 (17q25.3). *BIRC5: Survivin (17q25.3). *CHMP6: Charged multivesicular body protein 6 ( ... NF1: neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) (17q11.2). *SLC6A4: Serotonin transporter ...
... may contribute to relief from inflammatory bowel disease,[24] as in Crohn's disease,[25] ulcerative colitis,[26][27] and ... especially calcium.[78][79][80] Some plant foods can reduce the absorption of minerals and vitamins like calcium, zinc, vitamin ... Consistent intake of fermentable fiber may reduce the risk of chronic diseases.[92][93][94] Insufficient fiber in the diet can ... may reduce the risk of heart disease. A serving of [name of food product] supplies __ grams of the [necessary daily dietary ...
Thiamine pyrophosphate [30]. Thiamine (B1). None. 2-carbon groups, α cleavage. Bacteria, archaea and eukaryotes ... Clapham DE (2007). "Calcium signaling". Cell. 131 (6): 1047-58. doi:10.1016/j.cell.2007.11.028. PMID 18083096.. ... Jordan F, Patel MS (2004). Thiamine: catalytic mechanisms in normal and disease states. New York, N.Y: Marcel Dekker. p. 588. ... Wijayanti N, Katz N, Immenschuh S (2004). "Biology of heme in health and disease". Curr. Med. Chem. 11 (8): 981-6. doi:10.2174/ ...
萜烯和類萜(如類胡蘿蔔素)的生成是由異戊二烯單元的組合和修飾,異戊二烯單元是由活性的前驅體焦磷酸異戊烷(英语:isopentenyl pyrophosphate)及焦磷酸二甲基烯丙酯(英语:dimethylallyl pyrophosphate)提供[ ... Mechanism of nuclear calcium signaling by inositol 1,4,5-trisphosphate produced in the nucleus, nuclear located protein kinase ... A systemic review of the roles of n-3 fatty acids in health and disease. Journal of the American Dietetic
... (ADP), also known as adenosine pyrophosphate (APP), is an important organic compound in metabolism and is ... Belenky P, Bogan KL, Brenner C (January 2007). "NAD+ metabolism in health and disease". Trends Biochem. Sci. 32 (1): 12-9. doi: ...
Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and ... Calcium-sensing receptor. *GABAB (1. *2). *Glutamate receptor (Metabotropic glutamate (1 ...
... there is a less common form of gout that is caused by the formation of rhomboidal-shaped crystals of calcium pyrophosphate. ... Other forms of arthritis are rheumatoid arthritis and psoriatic arthritis, which are autoimmune diseases in which the body is ... The most common form of arthritis, osteoarthritis (also known as degenerative joint disease), occurs following trauma to the ...
... may contribute to relief from inflammatory bowel disease,[36] as in Crohn's disease,[37] ulcerative colitis,[38][39] and ... Raschka L, Daniel H (November 2005). "Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the ... Consistent intake of fermentable fiber may reduce the risk of chronic diseases.[105][106][107] Insufficient fiber in the diet ... may reduce the risk of heart disease. A serving of [name of food product] supplies __ grams of the [necessary daily dietary ...
Centers for Disease Control. p. 13. WHO/VRD/GEN/95.05.. HistoryEdit. *. Cornish-Bowden, Athel (1997). New Beer in an Old Bottle ... This molecule acts in calcium signaling by releasing calcium from intracellular stores.[61] It does this by binding to and ... "The participation of inorganic pyrophosphate in the reversible enzymatic synthesis of diphosphopyridine nucleotide" (PDF). J. ... Swerdlow RH (1998). "Is NADH effective in the treatment of Parkinson's disease?". Drugs Aging. 13 (4): 263-8. doi:10.2165/ ...
Failure in diagnosis of WE and thus treatment of the disease leads to death in approximately 20% of cases, while 75% are left ... The metabolically active form of thiamine is thiamine pyrophosphate, which plays a major role as a cofactor or coenzyme in ... The enzymes that are dependent on thiamine pyrophosphate are associated with the citric acid cycle (also known as the Krebs ... Sergei Korsakoff was a Russian physician after whom the disease "Korsakoff's syndrome" was named. In the late 1800s Korsakoff ...
In these diseases, reabsorption of divalent cations (such as magnesium and calcium) in the thick ascending limb of Henle's loop ... is related to thiamine deficiency because magnesium is needed for transforming thiamine into thiamine pyrophosphate. Loop and ... Thus, Crohn's disease, ulcerative colitis, Whipple's disease and celiac sprue can all cause hypomagnesemia. Postobstructive ... which in turn increases intracellular calcium by passively decreasing the action of the sodium-calcium exchanger in the ...
"Anticholinergics", Anticholinergic Agents, Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases, ... Respiratory disorders (e.g., asthma, chronic bronchitis, and chronic obstructive pulmonary disease [COPD]) ... and can be used to decrease secretions in allergic and inflammatory diseases. Anticholinergics relax smooth muscle in the ...
Wernicke's disease is one of the most prevalent neurological or neuropsychiatric diseases.[25] In autopsy series, features of ... A derivative of thiamine, thiamine pyrophosphate (TPP), is a cofactor involved in the citric acid cycle, as well as connecting ... R.E. Austic and M.L. Scott, Nutritional deficiency diseases, in Diseases of poultry, ed. by M.S. Hofstad, Iowa State University ... Mortality caused by Wernicke's disease reaches 17% of diseases, which means 3.4/1000 or about 25 million contemporaries.[27][28 ...
... immune-mediated diseases and airways disease". Immunology. 148 (1): 1-12. doi:10.1111/imm.12582. PMC 4819138. PMID 26778581.. ... which induces the release of calcium into the cytosol. Low calcium in the endoplasmic reticulum causes STIM1 clustering on the ... The most common phosphoantigens from animal and human cells (including cancer cells) are isopentenyl pyrophosphate (IPP) and ... This aggregated cytosolic calcium binds calmodulin, which can then activate calcineurin. Calcineurin, in turn, activates NFAT, ...
Bruce M Calcium Pyrophosphate Deposition Disease (radiology) Rothschild, Bruce M Calcium Pyrophosphate Deposition Disease ( ... Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a ... "Calcium Pyrophosphate Dihydrate Deposition Disease: Synovial Biopsy, Wrist". Rheumatology Image Bank. American College of ... "Clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition (CPPD) disease". UpToDate. This topic last ...
Bruce M Calcium Pyrophosphate Deposition Disease (radiology) *^ a b c d e f g h i j k l m n Rothschild, Bruce M Calcium ... Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a ... Calcium pyrophosphate dihydrate crystal deposition disease. From Wikipedia, the free encyclopedia. (Redirected from Calcium ... "Calcium Pyrophosphate Dihydrate Deposition Disease: Synovial Biopsy, Wrist". Rheumatology Image Bank. American College of ...
Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) occurs when these crystals form deposits in the joint and ... Calcium Pyrophosphate Deposition Disease (CPPD). What is CPPD (Pseudogout)?. Calcium pyrophosphate dihydrate crystal deposition ... In most cases, the cause of calcium pyrophosphate dihydrate crystal formation is unknown, although deposits increase as people ... The disease may take a few different arthritis-related forms: osteoarthritis, a chronic rheumatoid arthritis (RA)-like ...
Precipitation of crystals of calcium pyrophosphate dihydrate (CPP) in connective tissues may be asymptomatic or may be ... Pathogenesis and etiology of calcium pyrophosphate crystal deposition (CPPD) disease. *Patient education: Calcium pyrophosphate ... with calcium pyrophosphate deposition disease (also abbreviated as CPPD disease) as the umbrella term for all instances of CPP ... disease and Clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition (CPPD) disease.) ...
... is a metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate in and around joints, especially in ... encoded search term (Calcium Pyrophosphate Deposition Disease) and Calcium Pyrophosphate Deposition Disease What to Read Next ... Calcium pyrophosphate deposition disease (CPDD) is a metabolic arthropathy caused by the deposition of calcium pyrophosphate ... Calcium pyrophosphate deposition disease. Appearance of calcium pyrophosphate dihydrate crystals obtained from the knee of a ...
... is a type of arthritis caused by the deposition of calcium pyrophosphate crystals. Clinical Image Atlas : View clinical images ... Primary calcium pyrophosphate deposition disease. Calcium pyrophosphate deposition disease (CPDD) is divided into several ... Secondary calcium pyrophosphate deposition disease. The variety of calcium pyrophosphate deposition disease (CPDD) is ... Imaging in Calcium Pyrophosphate Deposition Disease) and Imaging in Calcium Pyrophosphate Deposition Disease What to Read Next ...
Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is slightly more prevalent in men. Chondrocalcinosis results ... Roentgenographic features of the arthropathy associated with CPPD crystal deposition disease. A comparative study with primary ... Calcium deposition is often seen at the triangular fibrocartilage of the wrist. Subchondral sclerosis, joint space narrowing, ... CPPD disease causes destruction of cartilage which can lead to radiographic findings similar to osteoarthritis. Sites of ...
An update on the epidemiology of calcium pyrophosphate dihydrate crystal deposition disease.. Richette P1, Bardin T, Doherty M. ... familial forms of CC and diseases associated with CC. We searched MEDLINE for articles published in English from 1998 to 2008 ...
Learn more about Calcium Pyrophosphate Dihydrate Deposition Disease at Medical City Dallas DefinitionCausesRisk ... Calcium pyrophosphate dihydrate deposition disease (CPPD) is a build up of calcium crystals in the joints. These crystals cause ... Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) (Pseudogout). The Arthritis Foundation website. Available at ... T114067/Calcium-pyrophosphate-dihydrate-deposition-disease: Wise JN, Weissman BN, et al. American College of Radiology (ACR) ...
calcium-pyrophosphate-dihydrate-deposition-disease definition: Proper noun 1. (medicine) A medical condition, also called ... calcium-pyrophosphate-dihydrate-deposition-disease. Proper noun *(medicine) A medical condition, also called pseudogout or CPPD ... www.yourdictionary.com/calcium-pyrophosphate-dihydrate-deposition-disease ... "calcium-pyrophosphate-dihydrate-deposition-disease." YourDictionary, n.d. Web. 17 January 2019. ,https://www.yourdictionary.com ...
Radiological Calcium Pyrophosphate Deposition Disease. Eric A. Brandser, M.D.. Peer Review Status: Internally Peer Reviewed ... Calcium pyrophosphate deposition disease, also known as pseudogout, is a very common entity. Radiographically, the presence of ... diagnose any disease or to suggest that liquid glucosamine will treat, cure, or prevent any disease.. Website designed and ... Incidentally, also noted in this patient is Pagets disease of the right tibia, consisting of enlargement of the proximal tibia ...
The effect of calcium and magnesium ions on calcium pyrophosphate crystal formation in aqueous solutions. J Rheumatol 1981;8: ... Methotrexate as an alternative therapy for chronic calcium pyrophosphate deposition disease: an exploratory analysis. Arthritis ... Dissolution of calcium pyrophosphate crystals by polyphosphates: an in vitro and ex vivo study. Ann Rheum Dis 2001;60:962-7. ... EULAR recommendations for calcium pyrophosphate crystal associated arthritis. Part I: Terminology and diagnosis. Ann Rheum Dis ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Calcium pyrophosphate crystal deposition disease & related comorbidities. Take Quiz. Gout occurrence and clinical detection. ... Which of the following conditions is commonly caused by calcium pyrophosphate crystal deposition disease (CPDD)? ... Rheumatoid arthritis and cardiovascular disease risk, Part 2. Take Quiz. Rheumatoid arthritis and cardiovascular disease risk, ... RA disease activity & clinical remission. Take Quiz. Sleep, catastrophizing, & central sensitization in knee osteoarthritis. ...
Distinguishing Gouty Arthritis from Calcium Pyrophosphate Disease and Other Arthritides. Christian Löffler, Horst Sattler, Lena ... Distinguishing Gouty Arthritis from Calcium Pyrophosphate Disease and Other Arthritides. Christian Löffler, Horst Sattler, Lena ... Distinguishing Gouty Arthritis from Calcium Pyrophosphate Disease and Other Arthritides Message Subject (Your Name) has ... Distinguishing Gouty Arthritis from Calcium Pyrophosphate Disease and Other Arthritides. Christian Löffler, Horst Sattler, Lena ...
Calcium pyrophosphate arthritis. Calcium pyrophosphate dihydrate deposition disease; CPPD disease; Acute/chronic CPPD arthritis ... Terkeltaub R. Calcium crystal disease: calcium pyrophosphate dihydrate and basic calcium phosphate. In: Firestein GS, Budd RC, ... Calcium pyrophosphate dihydrate (CPPD) arthritis is a joint disease that can cause attacks of arthritis. Like gout, crystals ... Deposition of calcium pyrophosphate dihydrate (CPPD) causes this form of arthritis. The buildup of this chemical forms crystals ...
... Common Name(s). Calcium pyrophosphate deposition disease (CPDD), Calcium ... "Calcium pyrophosphate deposition disease (CPDD)" (open studies are recruiting volunteers) and 28 "Calcium pyrophosphate ... Calcium pyrophosphate deposition disease (CPDD) (also known as chondrocalcinosis, pseudogout, or pyrophosphate arthopathy) is a ... The terms "Calcium pyrophosphate deposition disease (CPDD)" returned 0 free, full-text review articles on human participants. ...
... arthritis is a joint disease that can cause attacks of arthritis. Like gout, crystals form in the joints. But in this arthritis ... Terkeltaub R. Calcium crystal disease: calcium pyrophosphate dihydrate and basic calcium phosphate. In: Firestein GS, Budd RC, ... Calcium pyrophosphate dihydrate deposition disease; CPPD disease; Acute/chronic CPPD arthritis; Pseudogout; Pyrophosphate ... Calcium pyrophosphate dihydrate (CPPD) arthritis is a joint disease that can cause attacks of arthritis. Like gout, crystals ...
Calcium Pyrophosphate Arthritis - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - ... Calcium Pyrophosphate Arthritis (Calcium Pyrophosphate Dihydrate Crystal Deposition Disease; Acute Calcium Pyrophosphate ... Calcium Pyrophosphate Arthritis (Calcium Pyrophosphate Dihydrate Crystal Deposition Disease, Pyrophosphate Arthropathy, or ... Calcium pyrophosphate arthritis involves intra-articular and/or extra-articular deposition of calcium pyrophosphate dihydrate ( ...
... or symphysis pubis is virtually diagnostic of calcium pyrophosphate dehydrate deposition disease (CPPD) (Fig. 6-42). ...
Calcium pyrophosphate crystals were identified in the synovial fluid, and calcium pyrophosphate deposition disease was ... Calcium pyrophosphate deposition disease. N Engl J Med. 2016;374(26):2575-2584. doi:10.1056/NEJMra1511117 [CrossRef] [PubMed] ... Finckh A, Mc Carthy GM, Madigan A, et al Methotrexate in chronic-recurrent calcium pyrophosphate deposition disease: no ... Recurrent Painful Calcium Pyrophosphate Arthropathy You will receive an email whenever this article is corrected, updated, or ...
Causes and disease mechanisms. Calcium pyrophosphate is widely distributed in the body, and it is unclear why it sometimes ... Calcium pyrophosphate deposition disease. Some patients have a disorder similar to gout without synovial fluid uric acid ... Large joint involvement indicates severe disease. In early disease the findings are subtle, while in late disease there are ... Lyme disease. Lyme disease is a bacterial infection spread by the bite of an infected insect known as a deer tick. The first ...
Anteroposterior radiograph of the right knee linear calcifications in the meniscis consistent with chondrocalcinosis and osteophytes particularly in the medial joint compartment
In both the pyrophosphates are essentially eclipsed. Calcium Pyrophosphate Deposition Disease at eMedicine Ropp, R.C. (2013). " ... Calcium pyrophosphate (Ca2P2O7) is a chemical compound, an insoluble calcium salt containing the pyrophosphate anion. There are ... "Calcium pyrophosphate crystal deposition disease: Preparation and characterization of crystals". Journal of Crystal Growth. 87 ... dihydrate crystals in cartilage are responsible for the severe joint pain in cases of calcium pyrophosphate deposition disease ...
Calcium Pyrophosphate Dihydrate Crystal Deposition Disease): Read more about Symptoms, Diagnosis, Treatment, Complications, ... Calcium pyrophosphate deposition disease. [emedicine.medscape.com] Gout or hyperuricemia in an adolescent or child is rare but ... Calcium pyrophosphate crystal deposition disease: diagnosis and treatment. Open Access Rheumatology : Research and Reviews. ... 61 Volpe A...Furlani L 19467900 2009 48 An idiopathic case of calcium pyrophosphate dihydrate crystal deposition disease with ...
Diagnostic Rentability of Screening for Associated Conditions in Calcium Pyrophosphate Deposition Disease Patients ... Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When ... to diagnose metabolic conditions associated to calcium pyrophosphate deposition disease.. Comparison of Iron Absorption From ... ATP reacts reversibly with 5-phosphoribosyl-1-pyrophosphate to yield N-1-(5-phosphoribosyl)-ATP and pyrophosphate. EC 2.4.2.17 ...
Atypical Tumoral Presentation of Calcium Pyrophosphate Deposition Disease: A Case Report. Krochak, Ryan; Culbertson, Maya Deza ...
Imaging Characteristics of Calcium Pyrophosphate Dihydrate Crystal Deposition Disease. Lin, Yun-Yi; Wang, Tyng-Guey; Li, Ko-Jen ... Particle Disease Osteolysis of the Pelvis and the Hip After Hip Arthroplasty. Maltese, John T. Jr; LaBan, Myron M.; Gorab, ... Aggravated Dysphagia Caused by Cervical Osteophyte in a Patient with Parkinson Disease. Lee, Seung Hak; Bae, Soon Ook; Paik, ... Images are essential in the diagnosis, treatment, and rehabilitation of injury and disease. Many technologies have been ...
Ultrasound features of calcium pyrophosphate disease of the knee. Hyperechoic spots (white arrows) in the meniscus (A; lateral ... In the last decade, ultrasonography (US) has been found useful in diagnosing gout1 and calcium pyrophosphate disease (CPPD)2. ... Diagnosis of calcium pyrophosphate dihydrate crystal deposition disease: ultrasonographic criteria proposed. Ann Rheum Dis 2005 ... "Crystal clear"- sonographic assessment of gout and calcium pyrophosphate deposition disease. Semin Arthritis Rheum 2006;36:197- ...
The diagnosis of calcium pyrophosphate dihydrate crystal deposition disease (CPPD) until recent years has been mainly based on ... Filippou, G., & Frediani, B. (2012). The diagnosis of calcium pyrophosphate dihydrate crystal deposition disease: the good, the ... Change perspective to increase diagnostic accuracy of ultrasonography in calcium pyrophosphate dihydrate deposition disease! A ... The diagnosis of calcium pyrophosphate dihydrate crystal deposition disease: the good, the bad and… ultrasonography! https:// ...
  • Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a rheumatologic disease which is thought to be secondary to abnormal accumulation of calcium pyrophosphate dihydrate crystals within joint soft tissues. (wikipedia.org)
  • The disease may take a few different arthritis-related forms: osteoarthritis, a chronic rheumatoid arthritis (RA)-like inflammatory arthritis, or an acutely painful inflammatory condition called pseudogout. (arthritis.org)
  • The names traditionally used for the varying clinical manifestations of calcium pyrophosphate dihydrate (CPP) crystal deposition (CPPD) disease include pseudogout, chondrocalcinosis, and pyrophosphate arthropathy. (uptodate.com)
  • Calcium pyrophosphate crystal deposition disease, pseudogout, and articular chondrocalcinosis. (uptodate.com)
  • Calcium pyrophosphate deposition disease (CPDD) is divided into several varieties, primarily pseudogout and chondrocalcinosis . (medscape.com)
  • Synovial calcium pyrophosphate crystals, seen on polarizing microscopy, characterize pseudogout, an acute goutlike arthritis. (medscape.com)
  • Calcium pyrophosphate deposition disease, also known as pseudogout, is a very common entity. (glucosamine-arthritis.org)
  • Calcium pyrophosphate deposition disease (CPDD) (also known as chondrocalcinosis, pseudogout, or pyrophosphate arthopathy) is a joint disorder caused by the accumulation of calcium pyrophosphate dihydrate (CPPD) crystals in the joints and surrounding tissues. (diseaseinfosearch.org)
  • Manifestations are protean and may be minimal or include intermittent flares of acute arthritis, termed pseudogout or acute calcium pyrophosphate arthritis, and a degenerative arthropathy that is often severe. (merckmanuals.com)
  • CPPD disease sometimes causes attacks of pseudogout, characterized by one or more swollen, warm, painful red joints. (brighamandwomens.org)
  • Only a fraction of patients with CPPD disease will develop pseudogout in their lifetime. (brighamandwomens.org)
  • With pseudogout, however, the crystals are formed from a salt called calcium pyrophosphate dihydrate. (arthritis.org)
  • The main difference between the two ailments is that pseudogout is caused by calcium pyrophosphate dihydrate and gout is caused by uric acid. (empowher.com)
  • However, it is not uncommon for younger patients with acromegaly, hemochromatosis, ochronosis, parathyroid disease, thyroid disease or Wilson disease to develop pseudogout. (empowher.com)
  • To see if you have pseudogout, your doctor may take some X-rays and conduct a joint fluid examination to test for calcium pyrophosphate crystals. (empowher.com)
  • Pseudogout causes calcium crystals to form in cartilage and collect in fluid called synovial fluid that surrounds joints. (drugs.com)
  • Pseudogout is caused by calcium pyrophosphate dihydrate crystals in the joints. (healthline.com)
  • While pseudogout is caused by calcium pyrophosphate crystals, gout is caused by urate ( uric acid ) crystals. (healthline.com)
  • Pseudogout occurs when calcium pyrophosphate crystals form in the synovial fluid in the joints. (healthline.com)
  • calcium pysophosphate dihydrate, the crystalline substance deposited in cartilage and causing PSEUDOGOUT . (thefreedictionary.com)
  • These compounds can form crystals that cause joint symptoms similar to those of gout (including podagra), calcium pyrophosphate arthritis (previously called pseudogout), or sometimes other joint disorders. (merckmanuals.com)
  • Pseudogout, also a crystal-induced arthritis, is a condition with similar symptoms that results from deposits of calcium pyrophosphate dihydrate crystals in the joints. (thefreelibrary.com)
  • Interestingly, pyrophosphate arthropathy was described as pseudogout-like disease by Martel et al. (thefreedictionary.com)
  • If they can see crystals of calcium, it means you have a similar condition called pseudogout. (bupa.co.uk)
  • Pseudogout the Chondrocalcinosis is a very similar disease, caused by deposition of calcium pyrophosphate rather than uric acid. (medhelp.org)
  • Uric acid crystals are responsible in gout, while in pseudogout, the culprit is calcium pyrophosphate crystals. (healthinaging.org)
  • Also called calcium pyrophosphate deposition disease or CPPD, the common term "pseudogout" was coined for the condition's similarity to gout. (mayoclinic.org)
  • Pseudogout has been linked to the presence of calcium pyrophosphate dihydrate crystals within the affected joint. (mayoclinic.org)
  • The risk of pseudogout is higher for people who have excessive calcium or iron in their blood or too little magnesium. (mayoclinic.org)
  • Pseudogout among Patients Fulfilling a Billing Code Algorithm for Calcium Pyrophosphate Deposition Disease. (harvard.edu)
  • citation needed] The cause of CPPD disease is unknown. (wikipedia.org)
  • The disease is defined by presence of joint inflammation and the presence of CPPD crystals within the joint. (wikipedia.org)
  • By x-ray, CPPD can appear similar to other diseases such as ankylosing spondylitis and gout. (wikipedia.org)
  • Arthrocentesis, or removing synovial fluid from the affected joint, is performed to test the synovial fluid for the calcium pyrophosphate crystals that are present in CPPD. (wikipedia.org)
  • These two modalities currently define CPPD disease, but lack diagnostic accuracy. (wikipedia.org)
  • Thus, the diagnosis of CPPD disease is potentially epiphenomenological. (wikipedia.org)
  • CPPD crystal deposition disease was originally described over 50 years ago. (wikipedia.org)
  • Accordingly, calcium pyrophosphate deposition (CPPD) is an umbrella term for the various clinical subsets, whose naming reflects an emphasis on particular features. (wikipedia.org)
  • Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) occurs when these crystals form deposits in the joint and surrounding tissues. (arthritis.org)
  • These disorders, including acute inflammatory, chronic inflammatory, and degenerative arthropathies, as well as radiographic calcification, comprise the spectrum of calcium pyrophosphate crystal deposition (CPPD) disease [ 1-3 ]. (uptodate.com)
  • Treatment of CPPD disease is discussed here. (uptodate.com)
  • See 'Pathogenesis and etiology of calcium pyrophosphate crystal deposition (CPPD) disease' and 'Clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition (CPPD) disease' . (uptodate.com)
  • Each of these terms has both useful and problematic features [ 4,5 ] (see 'Clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition (CPPD) disease', section on 'Terminology' ). (uptodate.com)
  • Therefore, inorganic pyrophosphate can bind calcium, leading to CPPD deposition in the cartilage and synovium. (medscape.com)
  • Phosphate-to-pyrophosphate ratios less than 3 result in CPPD formation. (medscape.com)
  • Formation of CPPD crystals requires levels of pyrophosphate 10-40 times normal serum levels. (medscape.com)
  • Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is slightly more prevalent in men. (gentili.net)
  • There is a strong propensity of CPPD crystal deposition disease for the 2nd and 3rd metacarpophalangeal joints. (gentili.net)
  • Subchondral sclerosis, joint space narrowing, subchondral cyst formations which may be quite large, and intraarticular bodies from subchondral osseous collapse and fragmentation are all findings which can be seen in patient's with CPPD disease. (gentili.net)
  • CPPD disease causes destruction of cartilage which can lead to radiographic findings similar to osteoarthritis. (gentili.net)
  • Lack of an erosive process at the MCP joint differentiates CPPD crystal deposition disease from rheumatoid arthritis. (gentili.net)
  • Greater propensity for the MCP joints (also commonly includes the 4th and the 5th) with medial beak-like osteophytosis at the metacarpal heads and more widespread involvement of the carpal bones may help to differentiate hemochromatosis from idiopathic CPPD disease. (gentili.net)
  • Roentgenographic features of the arthropathy associated with CPPD crystal deposition disease. (gentili.net)
  • Calcium pyrophosphate dihydrate deposition disease (CPPD) is a build up of calcium crystals in the joints. (medicalcityhospital.com)
  • Objectives To develop evidence-based recommendations for management of calcium pyrophosphate deposition (CPPD). (bmj.com)
  • As discussed in Part I: Terminology and Diagnosis, 1 calcium pyrophosphate deposition (CPPD) may present different clinical phenotypes, from asymptomatic chondrocalcinosis (CC) to acute calcium pyrophosphate (CPP) crystal arthritis and osteoarthritis (OA) with CPPD, which may be associated with chronic symptoms and functional impairment of varying severity. (bmj.com)
  • Differentiating gout, calcium pyrophosphate deposition disease (CPPD), and non-crystal-related inflammatory arthropathies (non-CRA) is essential but often clinically impossible. (jrheum.org)
  • Calcium pyrophosphate dihydrate (CPPD) arthritis is a joint disease that can cause attacks of arthritis. (adam.com)
  • Deposition of calcium pyrophosphate dihydrate (CPPD) causes this form of arthritis . (adam.com)
  • Calcium pyrophosphate arthritis involves intra-articular and/or extra-articular deposition of calcium pyrophosphate dihydrate (CPPD) crystals. (merckmanuals.com)
  • CPPD crystal deposition (chondrocalcinosis, pyrophosphate arthropathy), whether symptomatic and asymptomatic, becomes more common with age. (merckmanuals.com)
  • Frequent association with other conditions, such as trauma (including surgery), hypomagnesemia , hyperparathyroidism , gout , hemochromatosis , and old age, suggests that calcium pyrophosphate dihydrate (CPPD) crystal deposits are secondary to degenerative or metabolic changes in the affected tissues. (merckmanuals.com)
  • Recent studies indicate that the ankyrin (ANK) protein is a central factor in producing excess extracellular pyrophosphate, which promotes CPPD crystal formation. (merckmanuals.com)
  • ANK protein is a putative transporter of intracellular and microvesicle pyrophosphate to the extracellular location where CPPD crystals form. (merckmanuals.com)
  • Chondrocalcinosis at the knee, wrist, or symphysis pubis is virtually diagnostic of calcium pyrophosphate dehydrate deposition disease (CPPD) (Fig. 6-42). (dieutridau.com)
  • Crystals of the tetrahydrate can be prepared by reacting sodium pyrophosphate, Na4P2O7 with calcium nitrate, Ca(NO3)2, at carefully controlled pH and temperature: Na4P2O7(aq)+2 Ca(NO3)2(aq)→ Ca2P2O7·4 H2O + 4 NaNO3 The dihydrate, sometimes termed CPPD, can be formed by the reaction of pyrophosphoric acid with calcium chloride: CaCl2 + H4P2O7(aq) → Ca2P2O7·2 H2O + HCl. (wikipedia.org)
  • CPPD disease, however, can mimic rheumatoid arthritis or polymyalgia rheumatica, and patients may present with symmetrical joint involvement. (symptoma.com)
  • Articular synovial calcification is common and may be due to calcium hydroxyapatite, as well as CPPD, particularly if advanced degenerative changes are present . (symptoma.com)
  • The diagnosis of calcium pyrophosphate dihydrate crystal deposition disease (CPPD) until recent years has been mainly based on the finding of typical crystals of calcium pyrophosphate dihydrate (CPP) in the synovial fluid of affected patients and on the presence of typical calcifications on plain X-rays. (reumatismo.org)
  • To compare the ability to detect calcium pyrophosphate (CPP) crystals deposition (CPPD) in knee cartilage by ultrasonography (US) and radiography. (jrheum.org)
  • In the last decade, ultrasonography (US) has been found useful in diagnosing gout 1 and calcium pyrophosphate disease (CPPD) 2 . (jrheum.org)
  • In addition, comparison between US and radiography for detecting CPPD, and the reproducibility of US in this disease, have not been widely investigated. (jrheum.org)
  • Calcium pyrophosphate crystal deposition (CPPD) disease is a common arthritis in adults caused by crystals (calcium pyrophosphate) in the joint. (brighamandwomens.org)
  • Notably, many patients with CPPD disease have no joint pain and may never develop joint pain. (brighamandwomens.org)
  • 60 years of age, underlying metabolic conditions associated with calcium pyrophosphate deposition (CPPD), such as hyperparathyroidism or hemochromatosis, should be investigated. (bmj.com)
  • Calcium pyrophosphate deposition (CPPD) is associated with both acute and chronic arthritis. (bmj.com)
  • Genetic factors in the pathogenesis of CPPD crystal deposition disease. (bmj.com)
  • Recent research has shown that CPPD disease is associated with various metabolic disorders such as hemochromatosis and hyperparathyroidism. (news-medical.net)
  • The chronic form of CPPD disease shows a chronic rheumatoid arthritis-like progression. (news-medical.net)
  • The close resemblance of CPPD disease to other forms of joint diseases makes the process of differential diagnosis a challenging task. (news-medical.net)
  • The treatment strategy for CPPD disease primarily focuses on relieving symptoms and improving joint function. (news-medical.net)
  • Even though the disease affects a good number of patients, CPPD disease is often neglected by the medical fraternity. (news-medical.net)
  • Other diseases, such as hemochromatosis and hypomagnesaemia, have an associated component with CPPD deposition. (thefreedictionary.com)
  • In addition to mimicking the clinical patterns of gout, the symptoms of CPPD joint disease may overlap with those of other inflammatory conditions. (thefreedictionary.com)
  • Sjögren's syndrome, Behçet's disease), calcium pyrophosphate dehydrate deposition disease (CPPD) and pigmented villonodular synovitis (PVNS) [11]. (termedia.pl)
  • Calcium pyrophosphate deposition disease (CPDD) is a metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate in and around joints , especially in articular cartilage and fibrocartilage (see the images below). (medscape.com)
  • Carpenter L, Juliano N, Herb R. Recurrent Painful Calcium Pyrophosphate Arthropathy. (jaoa.org)
  • Jaccoud arthropathy and pyrophosphate arthropathy: a rare association]. (semanticscholar.org)
  • Peripheral nerve entrapment at the wrist in pyrophosphate arthropathy. (semanticscholar.org)
  • Prevalence of periarticular calcifications in pyrophosphate arthropathy and their relation to nodal osteoarthrosis. (semanticscholar.org)
  • Pyrophosphate arthropathy: a study of metabolic associations and laboratory data. (semanticscholar.org)
  • 105 consecutive patients with pyrophosphate arthropathy have been studied. (semanticscholar.org)
  • Ultra-microcrystals in pyrophosphate arthropathy. (semanticscholar.org)
  • Unusual presentations of pyrophosphate arthropathy. (semanticscholar.org)
  • X-ray, CT, or other imaging usually shows accumulation of calcium within the joint cartilage, known as chondrocalcinosis. (wikipedia.org)
  • citation needed] Medical imaging, consisting of x-ray, CT, MRI, or ultrasound may detect chondrocalcinosis within the affected joint, indicating a substantial amount of calcium crystal deposition within the cartilage or ligaments. (wikipedia.org)
  • These patients have X-rays that show chondrocalcinosis, which is evidence of calcium pyrophosphate crystal deposits in the cartilage. (brighamandwomens.org)
  • It is sometimes called calcium pyrophosphate deposition disease, crystal deposition disease, or chondrocalcinosis. (thefreelibrary.com)
  • Deposition of dihydrate crystals in cartilage are responsible for the severe joint pain in cases of calcium pyrophosphate deposition disease (pseudo gout) whose symptoms are similar to those of gout. (wikipedia.org)
  • Gout or hyperuricemia in an adolescent or child is rare but invariably a manifestation of an underlying metabolic or inherited enzyme deficiency warranting a workup for these diseases. (symptoma.com)
  • The Centers for Disease Control and Prevention (CDC) report that 8.3 million Americans were affected by gout between 2007 to 2008. (medicalnewstoday.com)
  • Gout: A Disease of Kings. (medscape.com)
  • Wu M, Tian Y, Wang Q, Guo C. Gout: a disease involved with complicated immunoinflammatory responses: a narrative review. (medscape.com)
  • It is thought to be a chronic traction type injury, and it may occur in isolation or as a manifestation of a systemic disease such as seronegative spondyloarthropathies, rheumatoid arthritis, gout, or systemic lupus erythematosus. (amazonaws.com)
  • His other clinical interests include gout, rheumatoid arthritis, lupus and muscle disease. (medstarhealth.org)
  • Acute pseudopodagra is another joint disorder caused by basic calcium phosphate crystals and can mimic gout. (merckmanuals.com)
  • Gout is one of the most painful rheumatic diseases. (thefreelibrary.com)
  • Sometime during the course of the disease, gout will affect the big toe in about 75 percent of patients. (thefreelibrary.com)
  • Gout is a disease hallmarked by elevated levels of uric acid in your blood. (medhelp.org)
  • Treatment of symptomatic CPDD is important to prevent further end-organ damage, but it cannot reverse the joint disease. (medscape.com)
  • Although the exact mechanism for the development of CPDD remains unknown, increased adenosine triphosphate breakdown with resultant increased inorganic pyrophosphate in the joints results from aging, genetic factors, or both. (medscape.com)
  • Calcium pyrophosphate deposition disease (CPDD) is a type of arthritis caused by the deposition of calcium pyrophosphate crystals. (medscape.com)
  • Periarticular metacarpophalangeal and interphalangeal joint calcification may be a component of that form of calcium pyrophosphate deposition disease (CPDD). (medscape.com)
  • Pseudorheumatoid calcium pyrophosphate deposition disease (CPDD) has a polyarticular character. (medscape.com)
  • The skeletal and clinical distribution pattern of nonerosive components of primary calcium pyrophosphate deposition disease (CPDD) are shown in the table below. (medscape.com)
  • The variety of calcium pyrophosphate deposition disease (CPDD) is associated with rheumatoid arthritis or spondyloarthropathy . (medscape.com)
  • Which of the following conditions is commonly caused by calcium pyrophosphate crystal deposition disease (CPDD)? (mdedge.com)
  • Following organizations serve the condition "Calcium pyrophosphate deposition disease (CPDD)" for support, advocacy or research. (diseaseinfosearch.org)
  • Finding the right clinical trial for Calcium pyrophosphate deposition disease (CPDD) can be challenging. (diseaseinfosearch.org)
  • The terms "Calcium pyrophosphate deposition disease (CPDD)" returned 0 free, full-text research articles on human participants. (diseaseinfosearch.org)
  • Calcium pyrophosphate deposition (CPDD) disease is characterized by the accumulation of calcium crystals in the cartilage tissues of the joints. (news-medical.net)
  • It is also called calcium pyrophosphate deposition disease (CPDD). (drugs.com)
  • The term CPP deposition disease ( CPDD) is used to talk about the clinical syndromes caused by CPP crystals. (the-rheumatologist.org)
  • Several clinical features make clinicians suspect CPDD, she said, with the most obvious being aged 60 and older, as well as presence of one of the four Hs associated with the disease (e.g., hyperparathyroidism, hemochromatosis, hypomagnemesia and hypophosphatasia). (the-rheumatologist.org)
  • There may be no symptoms of calcium pyrophosphate arthritis between flares or continuous low-grade symptoms in multiple joints, similar to rheumatoid arthritis or osteoarthritis. (merckmanuals.com)
  • Osteoarthritis and rheumatoid arthritis are common, and represent two distinct but related mechanisms of joint disease in old age: respectively, "wear and tear" and inflammation. (encyclopedia.com)
  • books.google.com - One of the most prestigious, comprehensive texts on arthritis and related diseases, including osteoarthritis, rheumatoid arthritis, osteoporosis, lupus and more than one hundred others. (google.com)
  • Osteoarthritis (OA) also known as degenerativearthritis or degenerative joint disease or osteoarthrosis, is a group of mechanical abnormalities involving degradation of joints,including articular cartilage and subchondral bone. (amazonaws.com)
  • Rheumatoid arthritis is a chronic inflammatory disease of the joints that occurs when the body's immune system - which normally protects us from infection - mistakenly attacks the synovium, the thin membrane that lines the joints. (arthritis.org)
  • A term previously used to describe chronic diseases of the connective tissue (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue. (fpnotebook.com)
  • Erosive osteoarthrits, aka the hands, as well Diseases in Which Geodes Are Found Rheumatoid arthritis. (coursehero.com)
  • The differential diagnosis of diffuse arthralgias and myalgias includes the onset of an inflammatory rheumatic disease such as systemic lupus erythematosus or rheumatoid arthritis, a soft tissue syndrome such as fibromyalgia, somatization disorder or depression, endocrinopathy, infection such as a viral arthritis or Lyme disease, and toxic or drug reaction. (rheumatology.org)
  • Relationship Between Fish Consumption and Disease Activity in Rheumatoid Arthritis. (harvard.edu)
  • Gender differences in autoimmune disease. (springer.com)
  • Dr. Ligon has a clinical research focus on sarcoidosis, particularly musculoskeletal manifestations, extrapulmonary and cardiac disease, and situations of overlap with autoimmune disease. (pennmedicine.org)
  • Diagnosis of calcium pyrophosphate arthritis is established by identifying rhomboid- or rod-shaped crystals in synovial fluid that are not birefringent or are weakly positively birefringent on polarized light microscopy. (merckmanuals.com)
  • Calcium pyrophosphate crystals were identified in the synovial fluid, and calcium pyrophosphate deposition disease was diagnosed. (jaoa.org)
  • When synovial fluid (SF) analysis is not available, deposition of calcium pyrophosphate (CPP) crystals can be identified by imaging 3 . (jrheum.org)
  • EULAR recommendations for calcium pyrophosphate deposition. (bmj.com)
  • European League Against Rheumatism recommendations for calcium pyrophosphate deposition. (bmj.com)
  • the molecule used as energy currency in all living things), which results in increased pyrophosphate levels in joints, is thought to be one reason why crystals may develop. (wikipedia.org)
  • Crumbling-type erosions of calcium pyrophosphate deposition disease in the metacarpophalangeal and proximal and distal interphalangeal joints. (medscape.com)
  • Instead, x-rays of affected joints such as knees show characteristic deposits of calcium. (adam.com)
  • It is an active process, not just wearing out of joints or "degenerative joint disease" (Joint Working Group of the British Society for Rheumalology and, Research Unit of the Royal College of Physicians). (encyclopedia.com)
  • In late disease, joints can be totally destroyed. (encyclopedia.com)
  • Isotope bone scanning (scintigraphy) shows increased activity of the joints in early disease. (encyclopedia.com)
  • Liquids such as water help prevent more calcium buildup in your joints. (drugs.com)
  • Basic calcium phosphate crystals can destroy joints and cause severe inflammation in and around the joint. (merckmanuals.com)
  • Basic calcium crystals are sometimes visible on x-rays around the joints, and not usually in the joint cartilage. (merckmanuals.com)
  • The term CPP crystals refers to calcium pyrophosphate crystals , while the term CPP deposition is used to discuss the presence of crystals in joints. (the-rheumatologist.org)
  • Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. (curehunter.com)
  • Arthritis is a term that is often used to refer to the more than 100 different rheumatic diseases that affect the joints, muscles, and bones, and may also affect other connective tissues. (thefreelibrary.com)
  • In this stage, the disease has caused permanent damage to the affected joints and sometimes to the kidneys. (thefreelibrary.com)
  • Images are essential in the diagnosis, treatment, and rehabilitation of injury and disease. (lww.com)
  • The diagnosis of calcium pyrophosphate dihydrate crystal deposition disease: the good, the bad and… ultrasonography! (reumatismo.org)
  • Extra-articular manifestations of rheumatologic disease may be helpful in arriving at a more specific diagnosis. (aafp.org)
  • The combination of osteoporosis, anemia, elevated ESR, and kidney disease suggests a diagnosis of multiple myeloma. (rheumatology.org)
  • This was consistent with a diagnosis of crowned dens syndrome, an uncommon manifestation of calcium pyrophosphate dehydrate deposition disease. (mja.com.au)
  • The ANKH protein is involved in transport of inorganic pyrophosphate (PPi), which regulates calcification, bone mineralization, and bone resorption. (medscape.com)
  • The Primordial High Energy Compound: ATP or Inorganic Pyrophosphate? (wikipedia.org)
  • sometimes referred to as inorganic pyrophosphate (PP i ). (thefreedictionary.com)
  • This can be recognized grossly as a calcified sheet reflecting over the articular surface and as concretions of calcium pyrophosphate exuded beyond the subchondral articular surface. (medscape.com)
  • Calcium pyrophosphate arthritis is caused by deposition of articular calcium pyrophosphate (CPP) crystals. (bmj.com)
  • Six clinical factors are helpful in narrowing the possible causes: disease chronology, inflammation, distribution, extra-articular manifestations, disease course, and patient demographics. (aafp.org)
  • Terkeltaub R. Calcium crystal disease: calcium pyrophosphate dihydrate and basic calcium phosphate. (adam.com)
  • However, calcifications of hyaline cartilage and fibrocartilage seen on radiography can contain CPP crystals as well as basic calcium phosphate crystals 15 , 16 . (jrheum.org)
  • Basic calcium phosphate and calcium oxalate are chemical compounds that occur naturally in the body. (merckmanuals.com)
  • Basic calcium phosphate crystals and calcium oxalate crystals can also form in tendons and connective tissues. (merckmanuals.com)
  • Calcium oxalate crystals are visible under a microscope with polarized light, but basic calcium phosphate crystals, which are much smaller, usually can be seen only with a special stain or a special type of microscope (a transmission electron microscope). (merckmanuals.com)
  • Deposition of calcium pyrophosphate crystals into joint spaces can lead to severe, chronic arthritic attacks and damage to the cartilage. (jaoa.org)
  • Rhombus-shaped calcium pyrophosphate crystal seen in a knee arthrocentesis specimen. (wikipedia.org)
  • "Defining Characteristics of Patients with Overlap between Sarcoidosis and Connective Tissue Diseases"" American College of Rheumatology Annual Meeting, Chicago, IL : 2018. (pennmedicine.org)
  • The field of rheumatology is advancing almost daily as scientists learn more about rheumatic disease. (medstarhealth.org)
  • Do not test for Lyme disease as a cause of musculoskeletal symptoms without an exposure history and appropriate examination findings. (aafp.org)
  • Calcium pyrophosphate dihydrate crystals are associated with a range of clinical syndromes, which have been given various names, based upon which clinical symptoms or radiographic findings are most prominent. (wikipedia.org)
  • In addition to the symptoms of polymyositis, including pain and weakness of the muscles around the shoulders and pelvis, symptoms of dermatomyositis also include a patchy skin rash, purplish discoloration of the eyelids, swelling around the eyes, changes around the nail beds and calcium deposits in the shoulders, pelvis, hips, calves and thighs, which may limit motion. (arthritis.org)
  • Inherited platelet disorders constitute a large group of diseases involving a wide range of genetic defects that can lead to bleeding symptoms of varying severity. (gopetsamerica.com)
  • Precipitation of crystals of calcium pyrophosphate dihydrate (CPP) in connective tissues may be asymptomatic or may be associated with several clinical syndromes. (uptodate.com)
  • All patients underwent a clinical evaluation, including disease history and clinical examination. (jrheum.org)
  • Clinical aspects of calcium pyrophosphate dihydrate crystal deposition. (semanticscholar.org)
  • Do not test antinuclear antibody subserologies without a positive antinuclear antibody test result and clinical suspicion of immune-mediated disease. (aafp.org)
  • 4. Connective tissue disease a. (wikibooks.org)
  • Inflammatory and degenerative diseases of connective tissue structures, such as arthritis. (fpnotebook.com)
  • This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (fpnotebook.com)
  • Radiosynovectomy is intended for treating joint inflammation with synovial hypertrophy, especially in the course of connective tissue diseases. (termedia.pl)
  • The role of proteinases in the extracellular breakdown of the connective tissue matrix during disease processes is outlined. (biomedsearch.com)
  • In most cases, the cause of calcium pyrophosphate dihydrate crystal formation is unknown, although deposits increase as people get older. (arthritis.org)
  • To date, there are no effective treatments capable of dissolving calcium deposits. (symptoma.com)
  • Diagnostic mimicry in arthritis: patterns of joint involvement associated with calcium pyrophosphate dihydrate crystal deposits. (bmj.com)
  • Screening for secondary causes such as hyperparathyroidism or thyroid disease is appropriate. (rheumatology.org)
  • The calcifications can be explained by hyperparathyroidism against the background of long-term chronic kidney disease and calcium pyrophosphate deposition. (aerzteblatt.de)
  • Review: evidence that systemic sclerosis is a vascular disease. (medscape.com)
  • Less common indications include reactive arthritis, enteropathy-associated arthritis, other systemic diseases with joint involvement (e.g. (termedia.pl)
  • The purpose of this study is to determine whether thorough analytical evaluation is useful to diagnose metabolic conditions associated to calcium pyrophosphate deposition disease. (bioportfolio.com)
  • Other factors that show a strong association with this condition include joint trauma or sepsis, or procedures such as joint lavage, can cause shedding of calcium crystals into the joint. (news-medical.net)
  • Temporomandibular joint space in children without joint disease. (springer.com)
  • Smith HJ, Larheim TA, Aspestrand F. Rheumatic and nonrheumatic disease in the temporomandibular joint: gadolinium-enhanced MR imaging. (springer.com)
  • 2. Inflammatory joint diseases a. (wikibooks.org)
  • 6. Neuropathic osteoarthropathy (neuropathic joint disease) a. (wikibooks.org)
  • Most common joint disease in US. (unboundmedicine.com)
  • International guidelines also list idiopathic joint effusion and persistent inflammation associated with a joint prosthesis (foreign body reaction, polyethylene disease) [12, 13]. (termedia.pl)
  • Methods of assessing their role in disease processes is exemplified by new data on stromelysin activity in remodelling joint tissues in both model systems and human disease. (biomedsearch.com)
  • Subsequent workup showed normal parathyroid hormone, normal calcium and phosphorous levels, and normal magnesium and alkaline phosphatase. (symptoma.com)
  • Calcium and phosphorus levels are typically normal as well, as are parathyroid hormone and magnesium levels. (news-medical.net)
  • Calcium pyrophosphate arthritis should be suspected in older patients with arthritis, particularly inflammatory arthritis. (merckmanuals.com)
  • Risk of Hepatitis B Virus Reactivation in Patients With Inflammatory Arthritis Receiving Disease-Modifying Antirheumatic Drugs: A Systematic Review and Meta-Analysis. (harvard.edu)
  • Microscopic polyangiitis (MPA) is a rare disease in which the pathogenesis is unknown. (merckmanuals.com)
  • The platelet release reaction follows with the secretion of fibrinogen, von Willebrand factor, factor V, platelet factor 4, and B-thromboglobulin from the alpha granules and serotonin, calcium ions, ADP, and adenosine triphosphate (ATP) from the dense bodies. (gopetsamerica.com)
  • Past history: NIDDM, coronary artery disease, and CHF. (slideserve.com)
  • The ventilation-perfusion relation and gas exchange in mitral valve disease and coronary artery disease. (biomedsearch.com)
  • BACKGROUND: Patients with mitral valve disease (MVD) are at greater risk for respiratory complications after cardiac surgery compared with patients with coronary artery disease (CAD). (biomedsearch.com)
  • This enhanced medical reference book addresses the treatment of common and uncommon rheumatic disorders , with each chapter reviewing basic immunology and pathophysiology, important disease manifestations, and practical management issues. (elsevier.com)
  • Review basic immunology and pathophysiology , important disease manifestations, and practical management issues related to rheumatic disorders. (elsevier.com)
  • We report a 50-year-old woman who presented with an acute herniated disc syndrome secondary to an intraspinal inflammatory calcium pyrophosphate deposition disease mass at the level of the L4-L5 interspace. (symptoma.com)