A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)
A subclass of lectins that are specific for CARBOHYDRATES that contain MANNOSE.
A receptor that is specific for IGF-II and mannose-6-phosphate. The receptor is a 250-kDa single chain polypeptide which is unrelated in structure to the type 1 IGF receptor (RECEPTOR, IGF TYPE 1) and does not have a tyrosine kinase domain.
Phosphoric acid esters of mannose.
A nucleoside diphosphate sugar which can be converted to the deoxy sugar GDPfucose, which provides fucose for lipopolysaccharides of bacterial cell walls. Also acts as mannose donor for glycolipid synthesis.
A lipophilic glycosyl carrier of the monosaccharide mannose in the biosynthesis of oligosaccharide phospholipids and glycoproteins.
Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.
Enzymes that catalyze the transfer of mannose from a nucleoside diphosphate mannose to an acceptor molecule which is frequently another carbohydrate. The group includes EC 2.4.1.32, EC 2.4.1.48, EC 2.4.1.54, and EC 2.4.1.57.
An enzyme that catalyzes the reversible isomerization of D-mannose-6-phosphate to form D-fructose-6-phosphate, an important step in glycolysis. EC 5.3.1.8.
A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.
Polysaccharides consisting of mannose units.
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Glycoside hydrolases that catalyze the hydrolysis of alpha or beta linked MANNOSE.
Compounds functioning as activated glycosyl carriers in the biosynthesis of glycoproteins and glycophospholipids. They include the polyisoprenyl pyrophosphates.
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with an alcohol to form an acetal. They include both alpha- and beta-mannosides.
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
These compounds function as activated monosaccharide carriers in the biosynthesis of glycoproteins and oligosaccharide phospholipids. Obtained from a nucleoside diphosphate sugar and a polyisoprenyl phosphate.
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
The characteristic 3-dimensional shape of a carbohydrate.
Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Phosphoric acid esters of dolichol.
Mannosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with methyl alcohol. They include both alpha- and beta-methylmannosides.
The N-acetyl derivative of glucosamine.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A group of enzymes that catalyze an intramolecular transfer of a phosphate group. It has been shown in some cases that the enzyme has a functional phosphate group, which can act as the donor. These were previously listed under PHOSPHOTRANSFERASES (EC 2.7.-). (From Enzyme Nomenclature, 1992) EC 5.4.2.
An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.
A specific mannose-binding member of the collectin family of lectins. It binds to carbohydrate groups on invading pathogens and plays a key role in the MANNOSE-BINDING LECTIN COMPLEMENT PATHWAY.
These compounds function as activated glycosyl carriers in the biosynthesis of glycoproteins and glycophospholipids. Include the pyrophosphates.
Enzymes that catalyze the hydrolysis of N-acylhexosamine residues in N-acylhexosamides. Hexosaminidases also act on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES.
An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans. Defects in the lysosomal form of the enzyme in humans result in a buildup of mannoside intermediate metabolites and the disease BETA-MANNOSIDOSIS.
An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.
A group of related enzymes responsible for the endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose-content glycopeptides and GLYCOPROTEINS.
Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.
Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.
Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)
Eicosamethyl octacontanonadecasen-1-o1. Polyprenol found in animal tissues that contains about 20 isoprene residues, the one carrying the alcohol group being saturated.
The rate dynamics in chemical or physical systems.
The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
A class of C-type lectins that target the carbohydrate structures found on invading pathogens. Binding of collectins to microorganisms results in their agglutination and enhanced clearance. Collectins form trimers that may assemble into larger oligomers. Each collectin polypeptide chain consists of four regions: a relatively short N-terminal region, a collagen-like region, an alpha-helical coiled-coil region, and carbohydrate-binding region.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
An N-acetylglycosamine containing antiviral antibiotic obtained from Streptomyces lysosuperificus. It is also active against some bacteria and fungi, because it inhibits the glucosylation of proteins. Tunicamycin is used as tool in the study of microbial biosynthetic mechanisms.
A genetically heterogeneous group of heritable disorders resulting from defects in protein N-glycosylation.
The sum of the weight of all the atoms in a molecule.
Five-carbon furanose sugars in which the OXYGEN is replaced by a NITROGEN atom.
An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).
A group of inherited metabolic diseases characterized by the accumulation of excessive amounts of acid mucopolysaccharides, sphingolipids, and/or glycolipids in visceral and mesenchymal cells. Abnormal amounts of sphingolipids or glycolipids are present in neural tissue. INTELLECTUAL DISABILITY and skeletal changes, most notably dysostosis multiplex, occur frequently. (From Joynt, Clinical Neurology, 1992, Ch56, pp36-7)
A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Established cell cultures that have the potential to propagate indefinitely.
A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Compounds containing carbohydrate or glycosyl groups linked to phosphatidylinositols. They anchor GPI-LINKED PROTEINS or polysaccharides to cell membranes.
A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
An amidohydrolase that removes intact asparagine-linked oligosaccharide chains from glycoproteins. It requires the presence of more than two amino-acid residues in the substrate for activity. This enzyme was previously listed as EC 3.2.2.18.
A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.
The N-acetyl derivative of galactosamine.
Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.
Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. Endosomes internalize macromolecules bound by receptors on the cell surface.
Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.
The aggregation of suspended solids into larger clumps.
A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.
A plant genus in the family LILIACEAE (sometimes classified as Amaryllidaceae). Galanthus nivalis L. is the source of GALANTHAMINE.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
A class of enzymes that catalyzes the phosphorylation of fructose in the presence of ATP. EC 2.7.1.-.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Transport proteins that carry specific substances in the blood or across cell membranes.
The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.
A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Esters formed between the aldehydic carbon of sugars and the terminal phosphate of guanosine diphosphate.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Glycoproteins found on the membrane or surface of cells.
Serves as the biological precursor of insect chitin, of muramic acid in bacterial cell walls, and of sialic acids in mammalian glycoproteins.
A methylpentose whose L- isomer is found naturally in many plant glycosides and some gram-negative bacterial lipopolysaccharides.
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.
Proteins prepared by recombinant DNA technology.
A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
Polyhydric alcohols having no more than one hydroxy group attached to each carbon atom. They are formed by the reduction of the carbonyl group of a sugar to a hydroxyl group.(From Dorland, 28th ed)
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Phosphoric or pyrophosphoric acid esters of polyisoprenoids.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Glycoprotein molecules on the surface of B- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes.
Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.
Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.
The engulfing of liquids by cells by a process of invagination and closure of the cell membrane to form fluid-filled vacuoles.
Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)
Other names in common use include GDP mannose alpha-mannosyltransferase, and guanosine diphosphomannose-heteroglycan alpha- ... The systematic name of this enzyme class is GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase. ... the two substrates of this enzyme are GDP-mannose and heteroglycan, whereas its 3 products are GDP, 2-alpha-D-mannosyl- ... is an enzyme that catalyzes the chemical reaction GDP-mannose + heteroglycan ⇌ {\displaystyle \rightleftharpoons } GDP + 2(or 3 ...
Other names in common use include guanosine diphosphomannose-dolichol diphosphochitobiose, mannosyltransferase, and GDP-mannose ... The systematic name of this enzyme class is GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase. ... the two substrates of this enzyme are GDP-mannose and chitobiosyldiphosphodolichol, whereas its two products are GDP and beta-1 ... is an enzyme that catalyzes the chemical reaction GDP-mannose + chitobiosyldiphosphodolichol ⇌ {\displaystyle \ ...
Other names in common use include guanosine diphosphomannose-oligosaccharide-lipid, mannosyltransferase, GDP-mannose- ... Formation of an alpha-1,2-mannosyl-mannose linkage". J. Biol. Chem. 255 (9): 4170-5. PMID 6154707. Biology portal v t e. ... The systematic name of this enzyme class is GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase. ... is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to lipid ...
The systematic name of this enzyme class is GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase. Other names in common use ... include mannosyltransferase II, guanosine diphosphomannose-oligosaccharide-lipid II, mannosyltransferase, and GDP-mannose- ... is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to a ... lipid-linked oligosaccharide, being attached by an alpha-1,3-D-mannosyl-D-mannose bond. This enzyme belongs to the family of ...
... dolichyl-phospho-mannose synthase, GDP-mannose:dolichyl-phosphate mannosyltransferase, guanosine diphosphomannose-dolichol ... dolichyl-phosphate mannose synthase, GDP-mannose-dolichol phosphate mannosyltransferase, GDP-mannose-dolichylmonophosphate ... Bretthauer RK, Wu S, Irwin WE (1973). "Enzymatic transfer of mannose from guanosine diphosphate mannose to dolichol phosphate ... Richards JB, Hemming FW (1972). "The transfer of mannose from guanosine diphosphate mannose to dolichol phosphate and protein ...
The systematic name of this enzyme class is GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase. Other names ... guanosine diphosphomannose-phosphatidyl-inositol, alpha-mannosyltransferase, and phosphatidyl-myo-inositol alpha- ... an enzyme that catalyzes the chemical reaction in which at least one alpha-D-mannose residues are transferred from GDP-mannose ... in common use include GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase, GDPmannose:1-phosphatidyl-myo-inositol ...
GDP-mannose pyrophosphorylase, guanosine 5'-diphospho-D-mannose pyrophosphorylase, guanosine diphosphomannose pyrophosphorylase ... GDP-mannose Thus, the two substrates of this enzyme are GTP and alpha-D-mannose 1-phosphate, whereas its two products are ... alpha-D-mannose-1-phosphate guanylyltransferase. Other names in common use include GTP-mannose-1-phosphate guanylyltransferase ... and mannose 1-phosphate guanylyltransferase (guanosine triphosphate). This enzyme participates in fructose and mannose ...
GDP-mannose dehydrogenase, guanosine diphosphomannose dehydrogenase, and guanosine diphospho-D-mannose dehydrogenase. This ... In enzymology, a GDP-mannose 6-dehydrogenase (EC 1.1.1.132) is an enzyme that catalyzes the chemical reaction GDP-D-mannose + 2 ... The systematic name of this enzyme class is GDP-D-mannose:NAD+ 6-oxidoreductase. Other names in common use include guanosine ... 2 H+ The 3 substrates of this enzyme are GDP-D-mannose, NAD+, and H2O, whereas its 3 products are GDP-D-mannuronate, NADH, and ...
Guanosine diphosphate-mannose 1-phosphate guanylyltransferase Guanosine diphosphomannose phosphorylase Mannose 1-phosphate ... GDP mannose phosphorylase Mannose 1-phosphate (guanosine diphosphate) guanylyltransferase GDP mannose phosphorylase GDP-mannose ... GDP-mannose Thus, the two substrates of this enzyme are GDP and alpha-D-mannose 1-phosphate, whereas its two products are ... alpha-D-mannose-1-phosphate guanylyltransferase. This enzyme participates in fructose and mannose metabolism. ...
... guanosine diphosphomannose 4,6-dehydratase, GDP-D-mannose dehydratase, GDP-D-mannose 4,6-dehydratase, Gmd, and GDP-mannose 4,6- ... guanosine diphosphomannose 4,6-dehydratase, GDP-D-mannose dehydratase, GDP-D-mannose 4,6-dehydratase, GMD, and GDP-mannose 4,6- ... The chemical reaction of GDP-Mannose 4, 6-Dehydratase is as shown: GDP-mannose ↔ GDP-4-dehydro-6-deoxy-D-mannose + H2O The ... The enzyme GDP-Mannose 4, 6-Dehydratase is only present in one pathway that we know of. This pathway is the GDP-mannose- ...
Guanosine diphosphate mannose ChemIDplus Guanosine diphosphomannose ChemIDplus Guanosine pyrophosphate mannose ChemIDplus ... GDP-α-D-mannose (CHEBI:15820) is a GDP-D-mannose (CHEBI:84880) GDP-α-D-mannose (CHEBI:15820) is conjugate acid of GDP-α-D- ... GDP-6-deoxy-α-D-mannose (CHEBI:17661) has functional parent GDP-α-D-mannose (CHEBI:15820). GDP-α-D-mannose(2−) (CHEBI:57527) is ... D-mannose (CHEBI:15820). GDP-4-dehydro-6-deoxy-α-D-mannose (CHEBI:16955) has functional parent GDP-α-D-mannose (CHEBI:15820). ...
Guanosine diphosphomannose. *Guanosine pyrophosphate mannose. *MalaCards. *Medline Plus. 3123-67-9. *18396 ... GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol. *ALG1_HUMAN,Q9BT22 ...
guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase;. GDP-mannose-dolichol diphosphochitobiose ... GDP-alpha-D-mannose [CPD:C00096];. N-acetyl-beta-D-glucosaminyl-(1-,4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol. ... GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1-,4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol = GDP + beta-D- ... GDP-alpha-D-mannose:N-acetyl-beta-D-glucosaminyl-(1-,4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol 4-beta-D- ...
Other name(s): guanosine diphosphomannose dehydrogenase; GDP-mannose dehydrogenase; guanosine diphosphomannose dehydrogenase; ... Accepted name: GDP-mannose 6-dehydrogenase. Reaction: GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+. ... Comments: Also oxidizes D-mannose, 2-deoxy-D-glucose and 2-amino-2-deoxy-D-mannose.. Links to other databases: BRENDA, EXPASY, ... Glossary: dTDP-4-dehydro-β-L-rhamnose = dTDP-4-dehydro-6-deoxy-β-L-mannose. dTDP-β-L-rhamnose = dTDP-6-deoxy-β-L-mannose. Other ...
Other names in common use include GDP mannose alpha-mannosyltransferase, and guanosine diphosphomannose-heteroglycan alpha- ... The systematic name of this enzyme class is GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase. ... the two substrates of this enzyme are GDP-mannose and heteroglycan, whereas its 3 products are GDP, 2-alpha-D-mannosyl- ... is an enzyme that catalyzes the chemical reaction GDP-mannose + heteroglycan ⇌ {\displaystyle \rightleftharpoons } GDP + 2(or 3 ...
Other names in common use include guanosine diphosphomannose-dolichol diphosphochitobiose, mannosyltransferase, and GDP-mannose ... The systematic name of this enzyme class is GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase. ... the two substrates of this enzyme are GDP-mannose and chitobiosyldiphosphodolichol, whereas its two products are GDP and beta-1 ... is an enzyme that catalyzes the chemical reaction GDP-mannose + chitobiosyldiphosphodolichol ⇌ {\displaystyle \ ...
Guanosine diphosphate mannose. *Guanosine diphosphomannose. *Guanosine pyrophosphate mannose. Definition:. The alpha-anomer of ... GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose GDP-4-dehydro-6-deoxy-alpha-D-mannose GDP-6-deoxy-alpha-D-mannose Show first 5 Terms ... GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose GDP-4-dehydro-6-deoxy-alpha-D-mannose GDP-6-deoxy-alpha-D-mannose ...
2) GDP-α-D-mannose + 2-O-(6-O-acyl-α-D-mannosyl)-1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(6-O-acyl-α-D-mannosyl)-6-O-α-D- ... mannosyltransferase PimA; PimA; guanosine diphosphomannose-phosphatidyl-inositol α-mannosyltransferase (ambiguous). Systematic ... 1) GDP-α-D-mannose + 2-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol = GDP + 2,6-di-O-α-D-mannosyl-1-phosphatidyl-1D-myo- ... GDP-α-D-mannose + 1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(α-D-mannosyl)-1-phosphatidyl-1D-myo-inositol. ...
Guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase. GDP-mannose-oligosaccharide-lipid mannosyltransferase. ... an oxocarbenium ion-like transition state/intermediate is formed from GDP-mannose, and the mannose group is attached on the ... GDP-mannose. Man2-Ser/Thr O-glycan. (Man)n+9(GlcNAc)2-ASN N-glycan. GDP. Man3-Ser/Thr O-glycan. (Man)2n+9(GlcNAc)2-ASN N-glycan ... GDP-mannose is first transferred to a nucleophilic residue, Tyr220 in this enzyme, with an inversion of the configuration at C1 ...
... phosphatidylinositol dimannoside mannosyltransferase-E coli 01022698370 at Gentaur GDP-mannose-dependent alpha (1-6) ... Alpha-D-mannose-alpha-(1-6)-phosphatidylmyo-inositol-mannosyltransferase; Guanosine diphosphomannose-phosphatidyl-inositol ... The GDP-mannose-dependent alpha-(1-6) -phosphatidylinositol dimannoside mannosyltransferase is a α- or alpha protein sometimes ... GDP-mannose-dependent alpha-(1-6) -phosphatidylinositol dimannoside mannosyltransferase is a recombinant protein expressed in E ...
GDP-mannose pyrophosphorylase; guanosine 5-diphospho-D-mannose pyrophosphorylase; guanosine diphosphomannose pyrophosphorylase ... Reaction: GTP + α-D-mannose 1-phosphate = diphosphate + GDP-mannose. For diagram click here.. Other name(s): GTP mannose-1- ... mannose 1-phosphate guanylyltransferase (guanosine triphosphate). Systematic name: GTP:α-D-mannose-1-phosphate ... I. Guanosinediphosphate mannose pyrophosphorylase: purification and properties. J. Biol. Chem. 239 (1964) 3119-3126.. [EC 2.7. ...
A set of nucleotide primers(a forward and reverse) was selected to target a defined region of the guanosine diphospho-mannose( ...
... encoding mannose-1-phosphate guanylytransferase, are responsible for the biosynthesis of GDP-mannose from mannose-6-phosphate ( ... The similarities in the sequences of the deduced polypeptides of the encoded phosphomannomutase, guanosine diphosphomannose ( ... and GDP-mannose (man) pathway genes of an additional 11 and 13 serogroups that contain rhamnose and mannose in their respective ... Molecular evolution of the GDP-mannose pathway genes (manB and manC) in Salmonella enterica. Microbiology 147:599-610. ...
GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase) (Guanosine diphosphomannose-phosphatidyl-inositol ... GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase) (Guanosine diphosphomannose-phosphatidyl-inositol ... pimB Rv2188c] GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase (EC 2.4.1.346) (Alpha-D- ... pimA ML0452 MLCL581.14c] Phosphatidyl-myo-inositol mannosyltransferase (EC 2.4.1.345) (Alpha-mannosyltransferase) (GDP-mannose- ...
GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase) (Guanosine diphosphomannose-phosphatidyl-inositol ... GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase) (Guanosine diphosphomannose-phosphatidyl-inositol ...
  • Other names in common use include GDP mannose alpha-mannosyltransferase, and guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase. (wikipedia.org)
  • 1. Munch-Peterson, A. Enzymatic synthesis and phosphorolysis of guanosine diphosphate mannose. (qmul.ac.uk)
  • In enzymology, a heteroglycan alpha-mannosyltransferase (EC 2.4.1.48) is an enzyme that catalyzes the chemical reaction GDP-mannose + heteroglycan ⇌ {\displaystyle \rightleftharpoons } GDP + 2(or 3)-alpha-D-mannosyl-heteroglycan Thus, the two substrates of this enzyme are GDP-mannose and heteroglycan, whereas its 3 products are GDP, 2-alpha-D-mannosyl-heteroglycan, and 3-alpha-D-mannosyl-heteroglycan. (wikipedia.org)
  • The systematic name of this enzyme class is GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase. (wikipedia.org)
  • The systematic name of this enzyme class is GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase. (wikipedia.org)
  • The GDP-mannose-dependent alpha-(1-6) -phosphatidylinositol dimannoside mannosyltransferase is a α- or alpha protein sometimes glycoprotein present in blood. (phosphatidylinositol.com)