Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.Histamine H1 Antagonists: Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.Receptors, Histamine H1: A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.Tripelennamine: A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.Receptors, Histamine: Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.Metiamide: A histamine H2 receptor antagonist that is used as an anti-ulcer agent.Histamine Antagonists: Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.Histamine H1 Antagonists, Non-Sedating: A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.Receptors, Histamine H2: A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H2 receptors act via G-proteins to stimulate ADENYLYL CYCLASES. Among the many responses mediated by these receptors are gastric acid secretion, smooth muscle relaxation, inotropic and chronotropic effects on heart muscle, and inhibition of lymphocyte function. (From Biochem Soc Trans 1992 Feb;20(1):122-5)Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.Histamine H2 Antagonists: Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.Dimaprit: A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.Dealkylation: The removing of alkyl groups from a compound. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Self-Help Groups: Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs.Psychotherapy, Group: A form of therapy in which two or more patients participate under the guidance of one or more psychotherapists for the purpose of treating emotional disturbances, social maladjustments, and psychotic states.Newspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)Mass Media: Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.Pharmacists: Those persons legally qualified by education and training to engage in the practice of pharmacy.Dizziness: An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Postural Orthostatic Tachycardia Syndrome: A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)OhioLibrary Services: Services offered to the library user. They include reference and circulation.Capsules: Hard or soft soluble containers used for the oral administration of medicine.Libraries, MedicalPatents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.IrelandDrug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Web Browser: Software application for retrieving, presenting and traversing information resources on the World Wide Web.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Hospitals, AnimalVeterinarians: Individuals with a degree in veterinary medicine that provides them with training and qualifications to treat diseases and injuries of animals.Hypnotics and Sedatives: Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.Ketoconazole: Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)Analgesics, Non-Narcotic: A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.China: A country spanning from central Asia to the Pacific Ocean.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Hydrochloric Acid: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.

Dental anesthetic management of a patient with ventricular arrhythmias. (1/216)

During routine deep sedation for endodontic therapy, a dentist-anesthesiologist observed premature ventricular contractions (PVCs) on a 62-yr-old woman's electrocardiogram (EKG) tracing. The dentist was able to complete the root canal procedure under intravenous (i.v.) sedation without any problems. The dentist-anesthesiologist referred the patient for medical evaluation. She was found to be free from ischemic cardiac disease with normal ventricular function. The patient was cleared to continue her dental treatment with deep sedation. She subsequently continued to undergo dental treatment with deep intravenous sedation without incident, although her EKG exhibited frequent PVCs, up to 20 per minute, including couplets and episodes of trigeminy. This article will review indications for medical intervention, antiarrhythmic medications, and anesthetic interventions for perioperative PVCs.  (+info)

Transport characteristics of diphenhydramine in human intestinal epithelial Caco-2 cells: contribution of pH-dependent transport system. (2/216)

Transport characteristics of diphenhydramine, an antihistamine, were studied in cultured human intestinal Caco-2 cell monolayers to elucidate the mechanisms of its intestinal absorption. Diphenhydramine accumulation in the monolayers increased rapidly and was influenced by extracellular pH (pH 7.4 > 6.5 > 5.5). Diphenhydramine uptake was temperature dependent, saturable, and not potential sensitive. Kinetic analysis revealed that the apparent Km values were constant (0.8-1.0 mM) in all pH conditions tested, whereas Vmax values decreased at the lower pH. The initial uptake of diphenhydramine was competitively inhibited by another antihistamine, chlorpheniramine, with a Ki value of 1.3 mM. On the other hand, cimetidine and tetraethylammonium, typical substrates for the renal organic cation transport system, had no effect. Moreover, biological amines and neurotransmitters, such as histamine, dopamine, serotonin, and choline, also had no effect on the diphenhydramine accumulation. Finally, diphenhydramine uptake was stimulated by preloading monolayers with chlorpheniramine (trans-stimulation effect). These findings indicate that diphenhydramine transport in Caco-2 cells is mediated by a specific transport system. This pH-dependent transport system may contribute to the intestinal absorption of diphenhydramine.  (+info)

Safety and efficacy of a continuous infusion, patient controlled anti-emetic pump to facilitate outpatient administration of high-dose chemotherapy. (3/216)

We evaluated the combination of diphenhydramine, lorazepam, and dexamethasone delivered as a continuous i.v. infusion via an ambulatory infusion pump with patient-activated intermittent dosing (BAD pump) for prevention of acute and delayed nausea/vomiting in patients receiving high-dose chemotherapy (HDC) for peripheral blood progenitor cell (PBPC) mobilization (MOB) or prior to autologous PBPC rescue. The BAD pump was titrated to patient response and tolerance, and continued until the patient could tolerate oral anti-emetics. Forty-four patients utilized the BAD pump during 66 chemotherapy courses, 34 (52%) for MOB and 32 (48%) for HDC with autologous PBPC rescue. The median number of days on the BAD pump during MOB and HDC was 3 (1-6) and 9 (2-19) days, respectively. Complete overall or complete emesis control occurred on 94% of MOB and 89% of HDC treatment days during chemotherapy administration and 72% and 43%, respectively, following chemotherapy administration. Eighty-three percent of MOB and 55% of HDC treatment days were associated with no nausea. While on the BAD pump, no patient experienced severe toxicity or required hospitalization for management of nausea/vomiting. The BAD pump was safe and effective in minimizing nausea and vomiting associated with HDC, and thus, eliminated the need for hospitalization for management of chemotherapy-induced nausea and vomiting.  (+info)

Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies. (4/216)

Neoplasms in the brain are uncommon in control Fischer 344 (F344) rats; they occur at a rate of less than 1% in 2-yr toxicity/carcinogenicity studies. Furthermore, only 10 of nearly 500 studies conducted by the National Toxicology Program (NTP) showed any evidence of chemically related neoplastic effects in the brain. Generally, the brain tumor responses were considered equivocal, because the characteristics of potential neurocarcinogenic agents (such as statistically significant increased incidences, decreased latency and/or survival, and demonstration of dose-response relationships) were not observed. A thorough examination, including comparisons with a well-established historical database, is often critical in evaluating rare brain tumors. Chemicals that gave equivocal evidence of brain tumor responses were generally associated with carcinogenicity at other sites, and many chemicals were mutagenic when incubated with metabolic activating enzymes. Other factors that were supportive of the theory that marginal increases in brain tumor incidence were related to chemical exposure were that (a) some of the tumors were malignant, (b) no brain neoplasms were observed in concurrent controls from some studies, and/or (c) brain tumors were also seen following exposure to structurally related chemicals. In 2-yr studies in F344 rats (studies conducted by the NTP), equivocal evidence of carcinogenicity was observed for the following 9 chemicals: isoprene, bromoethane, chloroethane, 3,3'-dimethylbenzidine dihydrochloride, 3,3'-dimethoxybenzidine dihydrochloride, furosemide, C.I. direct blue 15, diphenhydramine hydrochloride, and 1-H-benzotriazole. Glycidol was the only chemical evaluated by the NTP with which there was clear evidence of brain tumor induction in F344 rats. Clarification of the potential neurocarcinogenic risks of chemicals that produce equivocal evidence of a brain tumor response in conventional 2-yr rodent studies may be aided by the use of transgenic mouse models that exhibit genetic alterations that reflect those present in human brain tumors as well as by the use of in utero exposures.  (+info)

Inhibition of Na(+) current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels. (5/216)

Diphenhydramine is an H1 histamine receptor antagonist, yet it also has a clinically useful local anesthetic effect. We found that diphenhydramine inhibits the neuronal Na(+) current, and the inhibition is stronger with more positive holding potentials. The dissociation constant between diphenhydramine and the inactivated Na(+) channel is approximately 10 microM, whereas the dissociation constant between diphenhydramine and the resting channel is more than 300 microM. The local anesthetic effect of diphenhydramine thus is ascribable to inhibition of Na(+) current by selective binding of the drug to the inactivated channels. Most interestingly, many other compounds, such as the anti-inflammatory drug diclofenac, the anticonvulsant drug phenytoin, the antidepressant drug imipramine, and the anticholinergic drug benztropine, have similar effects on neuronal Na(+) current. There is no apparent common motif in the chemical structure of these compounds, except that they all contain two phenyl groups. Molecular modeling further shows that the two benzene rings in all these drugs have very similar spatial orientations (stem bond angle, approximately 110 degrees; center-center distance, approximately 5 A). In contrast, the two phenyl groups in phenylbutazone, a drug that has only a slight effect on Na(+) current, are oriented in quite a different way. These findings strongly suggest that the two phenyl groups are the key ligands interacting with the channel. Because the binding counterpart of a benzene ring usually is also a benzene ring, some aromatic side chain groups of the Na(+) channel presumably are realigned during the gating process to make the very different affinity to the aforementioned drugs between the inactivated and the resting channels.  (+info)

Paclitaxel-associated hypersensitivity reactions: experience of the gynecologic oncology program of the Cleveland Clinic Cancer Center. (6/216)

PURPOSE: : This study expands the existing limited data as to whether patients developing clinically significant paclitaxel-induced hypersensitivity reactions can continue to be treated with this important antineoplastic agent and how such retreatment might be undertaken. PATIENTS AND METHODS: More than 450 patients received paclitaxel, either as a single agent or in a combination regimen, for a female pelvic malignancy in the Gynecologic Oncology Program of the Cleveland Clinic Cancer Center from January 1995 through December 1998. RESULTS: Of the more than 450 patients, 44 (approximately 9%) developed at least one episode of a clinically relevant hypersensitivity reaction to the cytotoxic drug. All 43 individuals (plus an additional four patients referred to our center after having previously experienced a severe paclitaxel-associated hypersensitivity reaction at another institution) who were retreated with paclitaxel were ultimately able to receive the agent. Five patients required treatment with a standardized desensitization regimen, developed by our group, to successfully receive paclitaxel. DISCUSSION: On the basis of this large single-institution study of paclitaxel-associated hypersensitivity reactions, we conclude that with appropriate precautions essentially all individuals experiencing these reactions can be safely treated with this agent.  (+info)

Concentration-effect relationship of intravenous lidocaine on the allodynia of complex regional pain syndrome types I and II. (7/216)

BACKGROUND: Several lines of evidence suggest that neuropathic pain (including Complex Regional Pain Syndrome [CRPS] I and CRPS II) is mediated in part by an increase in the density of voltage-sensitive sodium channels in injured axons and the dorsal root ganglion of injured axons. This study sought to characterize the effects of intravenous lidocaine (a sodium channel blocker) on acute sensory thresholds within the painful area and the size of the painful area in patients suffering from CRPS I and II. METHODS: This study used a randomized, double-blind, placebo-controlled design in 16 subjects suffering from CRPS I and II with a prominent allodynia. Each subject received an intravenous infusion of lidocaine and diphenhydramine separated by 1 week. A computer-controlled infusion pump targeted stair-step increases in plasma levels of lidocaine of 1, 2, and 3 microg/ml. At baseline and at each plasma level, spontaneous and evoked pain scores and neurosensory testing within the painful area were measured. The neurosensory testing consisted of thermal thresholds, tactile thresholds and the area of allodynia to punctate, and stroking and thermal stimuli. RESULTS: Intravenous lidocaine and diphenhydramine had no significant effect on the cool, warm, or cold pain thresholds. However, lidocaine caused a significant elevation of the hot pain thresholds in the painful area. Intravenous lidocaine caused a significantly decreased response to stroking and cool stimuli in the allodynic area. There was also a significant decrease in pain scores to cool stimuli at all plasma levels and the spontaneous pain at the highest plasma level. CONCLUSIONS: This study demonstrates that intravenous lidocaine affects pain in response to cool stimuli more than mechanical pain in subjects with neuropathic pain. There is a lesser effect on spontaneous pain and pain induced by stroking stimuli and no effect on the pain induced by punctate stimuli.  (+info)

Diphenhydramine disposition in the sheep maternal-placental-fetal unit: gestational age, plasma drug protein binding, and umbilical blood flow effects on clearance. (8/216)

The objective of this study was to examine the interrelationships between maternal and fetal plasma drug protein binding, umbilical blood flow (Q(um)), gestational age (GA), and maternal-fetal diphenhydramine (DPHM) clearances in chronically instrumented pregnant sheep. Maternal and fetal DPHM placental (CL(mf) and CL(fm), respectively) and nonplacental (CL(mo) and CL(fo), respectively) clearances and steady-state plasma protein binding were determined in 18 pregnant sheep at 124 to 140 days' gestation (term, approximately 145 days). The data demonstrated a highly significant fall of approximately 66% in CL(fm) and a decreasing trend in CL(fo) ( approximately 47%) over the GA range studied. However, no such relationships existed between GA and CL(mf) or CL(mo). Concomitant with this was a decrease in fetal DPHM plasma unbound fraction with GA, with no such change being evident in the mother. Both CL(mo) and CL(fo) were related to the respective DPHM plasma unbound fraction. A strong relationship also existed between fetal plasma unbound fraction and CL(fm). Thus, the decrease in fetal unbound fraction of DPHM during gestation could contribute to the fall in CL(fm), and possibly CL(fo). However, over the GA range studied, fetal DPHM free fraction decreased by approximately 47%, whereas CL(fm) fell by approximately 66%. Because fetal unbound fraction and CL(fm) are linearly related, the GA-associated fall in unbound fraction appears to be insufficient to account for the entire decline in CL(fm). In separate studies in pregnant sheep, we observed a approximately 40% fall in weight-normalized Q(um) between 125 and 137 days' gestation. Because CL(fm) for DPHM is similar to that of flow-limited compounds (e.g., ethanol, antipyrine), this decrease in Q(um) may also contribute to the GA-related fall in CL(fm).  (+info)

  • 7-10:1, methanol 45% m/m) combination for 28 days (n = 59), (2) placebo for 28 days (n = 65), or (3) 2 tablets of diphenhydramine (25 mg) for 14 days followed by placebo for 14 days (n = 60). (nih.gov)
  • The following medications should be used with caution when given with diphenhydramine: anticholinergic drugs, tricyclic antidepressants, and CNS depressant agents such as sedatives, anesthetics, and pain medications. (mullensmallanimalclinic.com)
  • Valerian produced slightly greater, though nonsignificant, reductions of sleep latency relative to placebo and diphenhydramine at the end of 14 days of treatment and greater reductions than placebo at the end of 28 days of treatment. (nih.gov)
  • Diphenhydramine produced significantly greater increases in sleep efficiency and a trend for increased total sleep time relative to placebo during the first 14 days of treatment. (nih.gov)
  • Patients in the valerian and diphenhydramine groups rated their insomnia severity lower relative to placebo at the end of 14 days of treatment. (nih.gov)
  • The findings show a modest hypnotic effect for a valerian-hops combination and diphenhydramine relative to placebo. (nih.gov)
  • PRECAUTIONS General: Diphenhydramine hydrochloride has an atropine-like action and, therefore should be used with caution in patients with a history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease or hypertension. (scribd.com)
  • tell your doctor and pharmacist if you are allergic to diphenhydramine, any other medications, or any of the ingredients in diphenhydramine preparations. (medlineplus.gov)
  • Diphenhydramine should not be used with additional tranquilizing medications. (veterinarypartner.com)
  • however, it contains a combination of diphenhydramine and other medications, including a dose of acetaminophen that could be lethal to a pet. (veterinarypartner.com)
  • This product contains only diphenhydramine, with no additional medications added. (veterinarypartner.com)
  • Diphenhydramine may interact with other medications. (petplace.com)
  • Diphenhydramine is effective to control muscle tremors caused by certain toxins and medications. (petcarerx.com)
  • It seems like it would contain diphenhydramine but, in fact, it contains a combination of diphenhydramine and other medications, including a dose of acetaminophen which could be lethal to a pet. (marvistavet.com)
  • To determine whether the commonly used over-the-counter medications dextromethorphan and diphenhydramine are superior to placebo for the treatment of nocturnal cough and sleep difficulty associated with upper respiratory infections and to determine whether parents have improved sleep quality when their children receive the medications when compared with placebo. (aappublications.org)
  • Diphenhydramine and similar drugs are often considered a better fit for patients than steroidal medications that can have stronger side effects. (skincareguide.com)
  • This generic Diphenhydramine RX card works for nearly all FDA-approved prescription medications, including diabetic test strips, at nearly all pharmacies in the U.S. for instant discounts, just like a generic Diphenhydramine coupon. (pscard.com)
  • Efficacy of diphenhydramine in the prevention of vertigo and nausea at 7 T MRI. (nih.gov)
  • In this study the potential of diphenhydramine in reducing respectively preventing vertigo and nausea induced by the ultra-high static magnetic field at 7 T was evaluated. (nih.gov)
  • This use is without indication and topical diphenhydramine should not be used as treatment for nausea because research does not indicate this therapy is more effective than alternatives. (wikipedia.org)
  • Diphenhydramine is frequently prescribed to treat itchy skin, though recent evidence-based guidelines for allergic skin disease have not found it to be particularly helpful except possibly in acute reactions involving hives. (veterinarypartner.com)
  • Acute intoxication by fentanyl, diphenhydramine, carfentanil and heroin. (mydeathspace.com)
  • Take diphenhydramine exactly as directed. (medlineplus.gov)
  • Take diphenhydramine exactly as directed by your doctor or pharmacist. (canada.com)
  • Is it safe to take diphenhydramine after surgery? (healthtap.com)
  • Nonprescription cough and cold combination products, including products that contain diphenhydramine, can cause serious side effects or death in young children. (medlineplus.gov)
  • If you are giving diphenhydramine or a combination product that contains diphenhydramine to a child, read the package label carefully to be sure that it is the right product for a child of that age. (medlineplus.gov)
  • Although Aleve PM contains diphenhydramine HCl, which can be used as both an antihistamine and a sleep aid, it is indicated as a sleep aid in this product. (aleve.com)
  • The side effects of dry mouth, increased heart rate, and difficulty urinating are more likely when diphenhydramine is used in conjunction with a tricyclic antidepressant, such as clomipramine . (veterinarypartner.com)
  • While generally safe and effective when prescribed by a veterinarian, diphenhydramine can cause side effects in some animals. (petplace.com)
  • There is evidence that the use of diphenhydramine among older adults or the elderly may result in serious side effects. (verywell.com)
  • Diphenhydramine causes a handful of common side effects that include sleepiness and decreased reaction times. (verywell.com)
  • Diphenhydramine hydrochloride was found to inhibit re-uptake of the neurotransmitter serotonin, which led to a search for viable antidepressants with similar structures and fewer side effects, such as selective serotonin re-uptake inhibitor (SSRI). (scbt.com)
  • Diphenhydramine - will taking too much nytol cause the tip of my tongue to go numb? (drugs.com)
  • In this report, the United States Diphenhydramine market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. (qyresearchreports.com)
  • In the recent times, the global market for United states diphenhydramine market report 2017 has surfaced as one of the most promising markets in the pharmaceutical industry, thanks to the significant rise in research and development activities by leading vendors of United states diphenhydramine market report 2017 across the world. (qyresearchreports.com)
  • What are the adverse effects of taking diphenhydramine with metformin? (drugs.com)
  • There were no significant residual effects and no serious adverse events with either valerian or diphenhydramine and no rebound insomnia following their discontinuation. (nih.gov)
  • Injectable diphenhydramine is available in 10 mg/ml and 50 mg/ml concentrations. (petplace.com)
  • Because of its sedative properties, diphenhydramine is widely used in nonprescription sleep aids for insomnia. (wikipedia.org)
  • When diphenhydramine is used to treat insomnia it is taken at bedtime (30 minutes before planned sleep). (medlineplus.gov)
  • Patients in the valerian and diphenhydramine groups rated their insomnia severity lower relative to placebo at the end of 14 days of treatment. (nih.gov)
  • Overall, these findings indicate that a valerian-hops combination and diphenhydramine might be useful adjuncts in the treatment of mild insomnia. (nih.gov)
  • Does Diphenhydramine Work Well to Treat Insomnia? (verywell.com)
  • Diphenhydramine is also used to relieve cough caused by minor throat or airway irritation. (medlineplus.gov)
  • Topical diphenhydramine is sometimes used especially for people in hospice. (wikipedia.org)
  • The strength of vertigo can be reduced by the application of diphenhydramine. (nih.gov)
  • Diphenhydramine, even at a low dose, reduces the strength of vertigo at ultra-high static magnetic fields, may be used preventively, and could pave the way to even higher field strength. (nih.gov)
  • Naproxen/diphenhydramine (trade name Aleve PM) is a formulation of naproxen with diphenhydramine marketed by Bayer Healthcare. (wikipedia.org)
  • The diphenhydramine HCl in Aleve PM acts as a sleep aid. (aleve.com)
  • Aleve PM also contains the sleep aid diphenhydramine HCl (25 mg). (aleve.com)
NON ASPIRIN PM EXTRA STRENGTH (acetaminophen, diphenhydramine hcl tablet, coated) | Healthgrades.com
NON ASPIRIN PM EXTRA STRENGTH (acetaminophen, diphenhydramine hcl tablet, coated) | Healthgrades.com (healthgrades.com)
Benadryl Allergy Side Effects: Common, Severe, Long Term - Drugs.com
Benadryl Allergy Side Effects: Common, Severe, Long Term - Drugs.com (drugs.com)
DailyMed - CONTRAST ALLERGY PREMED PACK- prednisone, diphenhydramine kit
DailyMed - CONTRAST ALLERGY PREMED PACK- prednisone, diphenhydramine kit (dailymed.nlm.nih.gov)
091526lbl | Syringe | Medical Treatments
091526lbl | Syringe | Medical Treatments (scribd.com)
40 Winks - definition of 40 Winks by The Free Dictionary
40 Winks - definition of 40 Winks by The Free Dictionary (thefreedictionary.com)
Rate your experience with this treatment
Rate your experience with this treatment (webmd.com)
Medication-Induced Dystonic Reactions Medication: Anticholinergic agents, Benzodiazepines
Medication-Induced Dystonic Reactions Medication: Anticholinergic agents, Benzodiazepines (emedicine.medscape.com)
Antihistamine (Oral Route, Parenteral Route, Rectal Route) Proper Use - Mayo Clinic
Antihistamine (Oral Route, Parenteral Route, Rectal Route) Proper Use - Mayo Clinic (mayoclinic.org)
Molecular Expressions: The Pharmaceutical Collection - Diphenhydramine (Benadryl)
Molecular Expressions: The Pharmaceutical Collection - Diphenhydramine (Benadryl) (micro.magnet.fsu.edu)
Popular OTC Sleep Aids for Insomnia
Popular OTC Sleep Aids for Insomnia (healthcentral.com)
Which medications in the drug class Antihistamines are used in the treatment of Bedbug Bites?
Which medications in the drug class Antihistamines are used in the treatment of Bedbug Bites? (medscape.com)
Acetaminophen - brand name list from Drugs.com
Acetaminophen - brand name list from Drugs.com (drugs.com)
Acetaminophen and Diphenhydramine | Memorial Sloan Kettering Cancer Center
Acetaminophen and Diphenhydramine | Memorial Sloan Kettering Cancer Center (mskcc.org)
Ind-Swift Limited Product Information | Medindia
Ind-Swift Limited Product Information | Medindia (medindia.net)
Over the Counter Treatments for Skin Rash | Livestrong.com
Over the Counter Treatments for Skin Rash | Livestrong.com (livestrong.com)
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Antihistamines for Asthma | Livestrong.com (livestrong.com)
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Polymorphic Eruption of Pregnancy Medication: Corticosteroids, Antihistamines, 1st Generation (emedicine.medscape.com)
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Banophen Prices, Coupons & Patient Assistance Programs - Drugs.com (drugs.com)
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Tylenol Sinus Congestion & Pain review | 31 facts and highlights (versus.com)
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Nurofen Express Liquid Capsules 200mg vs Tylenol Arthritis Pain | Perbandingan penghilang rasa sakit (versus.com)
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Dangers of Tylenol PM | LIVESTRONG.COM (livestrong.com)
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Goody's Extra Strength Caplets review | 23 facts and highlights (versus.com)
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Ulasan Sudafed PE Pressure Pain and Mucus | 29 fakta perbandingan (versus.com)
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Calprofen Ibuprofen Suspension review | 25 facts and highlights (versus.com)
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Dolormin Extra vs Nurofen Express Liquid Capsules 200mg vs Tylenol Arthritis Pain | Painkiller comparison (versus.com)
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Boots Paracetamol & Codeine Caplets | 26 fakta dan sorotan (versus.com)