A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
Facilities for the performance of services related to dental treatment but not done directly in the patient's mouth.
Individuals responsible for fabrication of dental appliances.
A branch of dentistry dealing with diseases of the oral and paraoral structures and the oral management of systemic diseases. (Hall, What is Oral Medicine, Anyway? Clinical Update: National Naval Dental Center, March 1991, p7-8)
The field of dentistry involved in procedures for designing and constructing dental appliances. It includes also the application of any technology to the field of dentistry.
The systematic study of the complete DNA sequences (GENOME) of organisms.
Individuals referred to for expert or professional advice or services.
Therapeutic approach tailoring therapy for genetically defined subgroups of patients.
Chemical substances that interrupt pregnancy after implantation.
A plant species of the genus PINUS that contains isocupressic acid.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Plant-derived ribosome-inactivating protein (RIP) purified from the Chinese medicinal herb tian-hua-fen which is obtained from the root tubers of Trichosanthes kirilowii. It has been used as an abortifacient and in the treatment of trophoblastic tumors. GLQ223 (Compound Q), a highly purified form of trichosanthin, has been proposed as antiviral treatment for AIDS.
Premature expulsion of the FETUS in animals.
Non-steroidal chemical compounds with abortifacient activity.
A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is a non-steroidal anti-inflammatory agent used for analgesia for postoperative pain and inhibits cyclooxygenase activity.
An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)
The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.
A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
Degradation of CORPUS LUTEUM. In the absence of pregnancy and diminishing trophic hormones, the corpus luteum undergoes luteolysis which is characterized by the involution and cessation of its endocrine function.
Contraction of the UTERINE MUSCLE.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.
A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
Anti-inflammatory analgesic.
Artificial device such as an externally-worn camera attached to a stimulator on the RETINA, OPTIC NERVE, or VISUAL CORTEX, intended to restore or amplify vision.
A clinical syndrome with intermittent abdominal pain characterized by sudden onset and cessation that is commonly seen in infants. It is usually associated with obstruction of the INTESTINES; of the CYSTIC DUCT; or of the URINARY TRACT.
Individuals with a degree in veterinary medicine that provides them with training and qualifications to treat diseases and injuries of animals.
1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.
Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It often becomes a REFERRED PAIN.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Organizations which are not operated for a profit and may be supported by endowments or private contributions.
Exclusive legal rights or privileges applied to inventions, plants, etc.
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
Deciduous plant rich in volatile oil (OILS, VOLATILE). It is used as a flavoring agent and has many other uses both internally and topically.
Pathological processes involving the STOMACH.
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.
An autosomal dominant porphyria that is due to a deficiency of COPROPORPHYRINOGEN OXIDASE in the LIVER, the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS.
Porphyrins with four methyl and four propionic acid side chains attached to the pyrrole rings. Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA.
An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.
A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Colorless reduced precursors of porphyrins in which the pyrrole rings are linked by methylene (-CH2-) bridges.

GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection. (1/2364)

Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-targeted mice (GM-/-) cleared group B streptococcus (GBS) from the lungs more slowly than wild-type mice. Expression of GM-CSF in the respiratory epithelium of GM-/- mice improved bacterial clearance to levels greater than that in wild-type GM+/+ mice. Acute aerosolization of GM-CSF to GM+/+ mice significantly enhanced clearance of GBS at 24 hours. GBS infection was associated with increased neutrophilic infiltration in lungs of GM-/- mice, while macrophage infiltrates predominated in wild-type mice, suggesting an abnormality in macrophage clearance of bacteria in the absence of GM-CSF. While phagocytosis of GBS was unaltered, production of superoxide radicals and hydrogen peroxide was markedly deficient in macrophages from GM-/- mice. Lipid peroxidation, assessed by measuring the isoprostane 8-iso-PGF2alpha, was decreased in the lungs of GM-/- mice. GM-CSF plays an important role in GBS clearance in vivo, mediated in part by its role in enhancing superoxide and hydrogen peroxide production and bacterial killing by alveolar macrophages.  (+info)

Possible role for ligand binding of histidine 81 in the second transmembrane domain of the rat prostaglandin F2alpha receptor. (2/2364)

For the five principal prostanoids PGD2, PGE2, PGF2alpha, prostacyclin and thromboxane A2 eight receptors have been identified that belong to the family of G-protein-coupled receptors. They display an overall homology of merely 30%. However, single amino acids in the transmembrane domains such as an Arg in the seventh transmembrane domain are highly conserved. This Arg has been identified as part of the ligand binding pocket. It interacts with the carboxyl group of the prostanoid. The aim of the current study was to analyze the potential role in ligand binding of His-81 in the second transmembrane domain of the rat PGF2alpha receptor, which is conserved among all PGF2alpha receptors from different species. Molecular modeling suggested that this residue is located in close proximity to the ligand binding pocket Arg 291 in the 7th transmembrane domain. The His81 (H) was exchanged by site-directed mutagenesis to Gln (Q), Asp (D), Arg (R), Ala (A) and Gly (G). The receptor molecules were N-terminally extended by a Flag epitope for immunological detection. All mutant proteins were expressed at levels between 50% and 80% of the wild type construct. The H81Q and H81D receptor bound PGF2alpha with 2-fold and 25-fold lower affinity, respectively, than the wild type receptor. Membranes of cells expressing the H81R, H81A or H81G mutants did not bind significant amounts of PGF2alpha. Wild type receptor and H81Q showed a shallow pH optimum for PGF2alpha binding around pH 5.5 with almost no reduction of binding at higher pH. In contrast the H81D mutant bound PGF2alpha with a sharp optimum at pH 4.5, a pH at which the Asp side chain is partially undissociated and may serve as a hydrogen bond donor as do His and Gln at higher pH values. The data indicate that the His-81 in the second transmembrane domain of the PGF2alpha receptor in concert with Arg-291 in the seventh transmembrane domain may be involved in ligand binding, most likely not by ionic interaction with the prostaglandin's carboxyl group but rather as a hydrogen bond donor.  (+info)

Production of prostaglandin f2alpha and its metabolite by endometrium and yolk sac placenta in late gestation in the tammar wallaby, Macropus Eugenii. (3/2364)

In this study, we investigated production of prostaglandin (PG) F2alpha and its metabolite, PGFM, by uterine tissues from tammar wallabies in late pregnancy. Endometrial explants were prepared from gravid and nongravid uteri of tammars between Day 18 of gestation (primitive streak) and Day 26.5 (term) and were incubated in Ham's F-10 medium supplemented with glutamine and antibiotics for 20 h. PGF2alpha and PGFM in the medium were assayed by specific, validated RIAs. Control tissues (leg muscle) did not produce detectable amounts of either PG. Both gravid and nongravid endometria secreted PGF2alpha, and production increased significantly in both gravid and nongravid uteri towards term. PGFM was produced in small amounts by both gravid and nongravid uteri, and the rate of production did not increase. Neither oxytocin nor dexamethasone stimulated PG production in vitro in any tissue at any stage. Thus, the surge in peripheral plasma PGFM levels seen at parturition may arise from increased uterine PG production, but further study is needed to define what triggers this release.  (+info)

Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-tau in bovine endometrial cells. (4/2364)

Oxytocin (OT) is responsible for the episodic release of luteolytic prostaglandin (PG) F2alpha from the uterus in ruminants. The attenuation of OT-stimulated uterine PGF2alpha secretion by interferon-tau (IFN-tau) is essential for prevention of luteolysis during pregnancy in cows. To better understand the mechanisms involved, the effect of recombinant bovine IFN-tau (rbIFN-tau) on OT-induced PG production and cyclooxygenase-2 (COX-2) and PGF synthase (PGFS) expression in cultured endometrial epithelial cells was investigated. Cells were obtained from cows at Days 1-3 of the estrous cycle and cultured to confluence in RPMI medium supplemented with 5% steroid-free fetal calf serum. The cells were then incubated in the presence or absence of either 100 ng/ml OT or OT+100 ng/ml rbIFN-tau for 3, 6, 12, and 24 h. OT significantly increased PGF2alpha and PGE2 secretion at all time points (p < 0.01), while rbIFN-tau inhibited the OT-induced PG production and reduced OT receptor binding in a time-dependent manner. OT increased the steady-state level of COX-2 mRNA, measured by Northern blot, which was maximal at 3 h (9-fold increase) and then decreased with time (p < 0.01). OT also caused an increase in COX-2 protein, which peaked at 12 h (11-fold increase), as measured by Western blot. Addition of rbIFN-tau suppressed the induction of COX-2 mRNA (89%, p < 0.01) and COX-2 protein (50%, p < 0.01) by OT. OT also increased PGFS mRNA, and this stimulation was attenuated by rbIFN-tau (p < 0.01). To ensure that the decrease in COX-2 was not solely due to down-regulation of the OT receptor, cells were stimulated with a phorbol ester (phorbol 12-myristate 13-acetate; PMA) in the presence and absence of rbIFN-tau. The results showed that rbIFN-tau also decreased PMA-stimulated PG production and COX-2 protein. It can be concluded that rbIFN-tau inhibition of OT-stimulated PG production is due to down-regulation of OT receptor, COX-2, and PGFS.  (+info)

Neurogenic vasodilatation of canine isolated small labial arteries. (5/2364)

Mechanisms underlying vasodilatation to nerve stimulation by electrical pulses and nicotine were analyzed in isolated canine small labial arteries. Transmural electrical stimulation (5 and 20 Hz) produced a contraction followed by a relaxation in labial arterial strips denuded of the endothelium, partially contracted with prostaglandin F2alpha. The contraction was abolished by prazosin or combined treatment with alpha, beta-methylene ATP. In the treated strips, neurogenic relaxation was abolished by NG-nitro-L-arginine (L-NA), a nitric oxide (NO) synthase inhibitor, and restored by L-arginine. The D-enantiomers were without effect. Nicotine (10(-4) M) also relaxed the arteries, in which the contractile response was abolished by prazosin and alpha, beta-methylene ATP. The relaxant response was attenuated but not abolished by L-NA; the inhibition was reversed by L-arginine. The remaining relaxation by nicotine was abolished by calcitonin gene-related peptide (CGRP)-[8 to 37], a CGRP1 receptor antagonist. Relaxations elicited by a lower concentration of nicotine (2 x 10(-5) M) sufficient to produce similar magnitudes of response to those induced by 5-Hz electrical nerve stimulation were also inhibited partially by L-NA. Histochemical study with the NADPH-diaphorase method demonstrated positively stained nerve fibers and bundles in the arterial wall, suggesting the presence of neuronal NO synthase. It is concluded that the relaxation induced by electrical nerve stimulation of small labial arteries is mediated exclusively by NO synthesized from L-arginine in nerve terminals, whereas nicotine in the concentrations used evokes relaxations by a mediation of nerve-derived NO and also CGRP, possibly from sensory nerves. The reason why nicotine but not electrical pulses stimulates sensory nerves and elicits vasorelaxation remains unsolved.  (+info)

Role of iNOS in the vasodilator responses induced by L-arginine in the middle cerebral artery from normotensive and hypertensive rats. (6/2364)

1. The substrate of nitric oxide synthase (NOS), L-arginine (L-Arg, 0.01 microM - 1 mM), induced endothelium-independent relaxations in segments of middle cerebral arteries (MCAs) from normotensive Wistar-Kyoto (WKY) and hypertensive rats (SHR) precontracted with prostaglandin F2alpha (PGF2alpha). These relaxations were higher in SHR than WKY arteries. 2. L-N(G)-nitroarginine methyl ester (L-NAME) and 2-amine-5,6-dihydro-6-methyl-4H-1,3-tiazine (AMT), unspecific and inducible NOS (iNOS) inhibitors, respectively, reduced those relaxations, specially in SHR. 3. Four- and seven-hours incubation with dexamethasone reduced the relaxations in MCAs from WKY and SHR, respectively. 4. Polymyxin B and calphostin C, protein kinase C (PKC) inhibitors, reduced the L-Arg-induced relaxation. 5. Lipopolysaccharide (LPS, 7 h incubation) unaltered and inhibited these relaxations in WKY and SHR segments, respectively. LPS antagonized the effect polymyxin B in WKY and potentiated L-Arg-induced relaxations in SHR in the presence of polymyxin B. 6. The contraction induced by PGF2alpha was greater in SHR than WKY arteries. This contraction was potentiated by dexamethasone and polymyxin B although the effect of polymyxin B was higher in SHR segments. LPS reduced that contraction and antagonized dexamethasone- and polymyxin B-induced potentiation, these effects being greater in arteries from SHR. 7. These results suggest that in MCAs: (1) the induction of iNOS participates in the L-Arg relaxation and modulates the contraction to PGF2alpha; (2) that induction is partially mediated by a PKC-dependent mechanism; and (3) the involvement of iNOS in such responses is greater in the hypertensive strain.  (+info)

Control of luteolysis in the one-humped camel (Camelus dromedarius). (7/2364)

Blood plasma concentrations of 13,14-dihydro-15-keto PGF2 alpha (PGFM) were measured in groups of mature non-pregnant and pregnant camels to study PGF2 alpha release patterns around the time of luteolysis and the timing of the signal for pregnancy recognition. Injection of each of four camels with 10 and 50 mg of PGF2 alpha showed clearly that five times the dose of exogenous hormone produced five times the amount of PGFM in peripheral plasma, thereby indicating that, as in other animal species, PGFM is the principal metabolite of PGF2 alpha in the camel. Serial sampling of three non-pregnant camels on each of days 8, 10 and 12, and three pregnant camels on day 10, after ovulation for 8 h showed a significant (P < 0.05) rise in mean plasma PGFM concentrations only on day 10 in the non-pregnant, but not the pregnant, animals. A single intravenous injection of 20, 50 or 100 iu oxytocin given to three groups of three non-pregnant camels on day 10 after ovulation did not increase their basal serum PGFM concentrations. However, daily treatment of six non-pregnant camels between days 6 and 15 (n = 3) or 20 (n = 3) after ovulation with 1-2 g of the prostaglandin synthetase inhibitor, meclofenamic acid, inhibited PGF2 alpha release and thereby resulted in continued progesterone secretion throughout the period of meclofenamic acid administration. These results showed that, as in other large domestic animal species, release of PGF2 alpha from, presumably, the endometrium controls luteolysis in the dromedary camel. Furthermore, reduction in the amount of PGF2 alpha released is associated with luteal maintenance and the embryonic signal for maternal recognition of pregnancy must be transmitted before day 10 after ovulation if luteostasis is to be achieved. However, the results also indicate that, in contrast to ruminants, the release of endometrial PGF2 alpha in the non-pregnant camel may not be controlled by the release of oxytocin.  (+info)

Effects of prostaglandin F2 alpha on intracellular pH, intracellular calcium, cell shortening and L-type calcium currents in rat myocytes. (8/2364)

OBJECTIVE: We have studied the mechanisms underlying the positive inotropic action of prostaglandin F2 alpha (PGF2 alpha) by monitoring intracellular calcium transients, intracellular pH, L-type calcium currents and cell shortening in isolated ventricular myocytes. METHODS: Rat myocytes were loaded with fura-2AM for intracellular calcium measurements, or BCECF-AM for pH measurements. Cell shortening was recorded using an edge detection system, and L-type calcium currents measured using whole cell patch clamping. RESULTS: PGF2 alpha (3 nmol l-1-3 mumol l-1 increased single myocyte shortening and reduced resting cell length in a concentration-dependent manner. While myocyte shortening was increased by PGF2 alpha, this was not associated with any change in the amplitude of intracellular calcium transients, diastolic calcium, or L-type calcium currents. However, the same myocytes were capable of responding to catecholamines with increases in calcium transient amplitude and L-type calcium currents. PGF2 alpha (3 mumol l-1 caused a reversible rise in intracellular pH of 0.08 +/- 0.01 pH units (n = 5, p < 0.05). The Na(+)-H+ exchanger inhibitor, HOE 694 (10 mumol l-1, abolished the PGF2 alpha-induced rise in pH and the increase in cell shortening. PGF2 alpha-induced increases in cell shortening and intracellular pH were also attenuated by the protein kinase C (PKC) inhibitor, chelerythrine (2 mumol l-1. CONCLUSION: The positive inotropic action of PGF2 alpha appears to be mediated via activation of the Na(+)-H+ exchanger with the possible involvement of PKC. This suggests that PGF2 alpha-produces intracellular alkalosis, which then sensitizes cardiac myofilaments to calcium.  (+info)

8-epi-PGF2α(8-Epi-Prostaglandin F2 Alpha) ELISA Kit is available at Gentaur for Next week Delivery. Alias:8-epi-PGF2α(8-Epi-Prostaglandin F2 Alpha) Detection method:Competitive ELISA, Coated with.... ...
For those of you who like the cutting edge or want to help the KDE developers continue their phenomenal development pace, but arent yet ready to compile from CVS, the KDE Project has just released KDE 2.2alpha1. A list of some of the significant additions and improvements versus the recent 2.1 release is below (please add any unlisted significant changes in the comments section), as well as a list of currently available pre-compiled binaries (please read the KDE Binary Packages Policy). Please bear in mind that this is an alpha release and those enjoying a stable desktop should use KDE 2.1.1.
For those of you who like the cutting edge or want to help the KDE developers continue their phenomenal development pace, but arent yet ready to compile from CVS, the KDE Project has just released KDE 2.2alpha1. A list of some of the significant additions and improvements versus the recent 2.1 release is below (please add any unlisted significant changes in the comments section), as well as a list of currently available pre-compiled binaries (please read the KDE Binary Packages Policy). Please bear in mind that this is an alpha release and those enjoying a stable desktop should use KDE 2.1.1.
The objective of the present study was to investigate in rabbit corpora lutea (CL), at both the cellular and molecular level, intraluteal cyclooxygenase (COX)-1, COX-2 and prostaglandin (PG) E2-9-ketoreductase (PGE2-9-K) enzymatic activities as well as in vitro PGE2 and PGF2alpha synthesis following PGF2alpha treatment at either early- (day-4) or mid-luteal (day-9) stage of pseudopregnancy. By immunohistochemistry, positive staining for COX-2 was localized in luteal and endothelial cells of stromal arteries at both the stages. In CL of both stages, basal COX-2 mRNA levels were poorly expressed, but rose (P , 0.01) 4- to 10-fold 1.5-6 h after treatment and then gradually decreased within 24 h. Compared to mid-stage, day-4 CL had lower (P , 0.01) COX-2 and PGE2-9-K basal activities, and PGF2alpha synthesis rate, but higher (P , 0.01) PGE2 production. Independent of luteal stage, PGF2alpha treatment did not affect COX-1 activity. In day-4 CL, PGF2alpha induced an increase (P , 0.01) in both COX-2 ...
In this study we report that 8-iso-PGF2α, a major and stable product of lipid peroxidation, was potent in causing cell death of cultured brain microvascular endothelial cells as well as of ex vivo preparation of microvessels but not of human umbilical vein endothelium, smooth muscle, or astroglia; another related isoprostane, 8-iso-PGE2, did not trigger endothelial cell death. 8-Iso-PGF2α-induced cytotoxicity was TXA2 dependent and mostly of oncotic nature. Associated with these effects, intraventricular injection of 8-iso-PGF2α caused cystlike formations in the periventricular area.. The nature of cell death induced by 8-iso-PGF2α seems to be primarily oncotic rather than apoptotic necrosis (Figure 2). This inference is supported by the data that 8-iso-PGF2α caused ,8% of cell DNA fragmentation, a time-dependent increase in PI incorporation and LDH release, indicative of membrane disruption (Figure 2), and its effects, as well as those of its mediator TXA2, were unaltered by caspase ...
These results suggest that repeated sauna therapy may protect against oxidative stress, which leads to the prevention of atherosclerosis.
Endothelin-1 stimulates prostaglandin F2 alpha release from human endometrium.: Despite a key role in the pathogenesis of menorrhagia, the factors controlling t
Lutalyse 5 mg/ml Injection 30ml. Cattle To more effectively control the time of oestrus in cycling cows. To treat cows which have...
Our objective was to evaluate the effect of a second PGF2α treatment (25 mg of dinoprost) or a double dose of PGF2α (50 mg of dinoprost) during a Resynch protocol on luteal regression and pregnancies per artificial insemination (P/AI) in lactating dairy cows. Lactating Holstein cows (n = 1,100) were randomly assigned at a nonpregnancy diagnosis to receive (1) Ovsynch (control: 100 µg of GnRH; 7 d, 25 mg of PGF2α; 56 h, 100 µg of GnRH), (2) Ovsynch with a second PGF2α treatment (GPPG: 100 µg of GnRH; 7 d, 25 mg of PGF2α; 24 h, 25 mg of PGF2α; 32 h, 100 µg of GnRH), or (3) Ovsynch with a double dose of PGF2α (GDDP: 100 µg of GnRH; 7 d, 50 mg of PGF2α; 56 h, 100 µg of GnRH ...
Advice for mothers using Unoprostone (Rescula) while breastfeeding. Includes possible effects on breastfed infants and lactation.
The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.
Anonymous Access: cvs -d :pserver:[email protected]:/var/cvsroot co gentoo-x86/media-gfx/pixels2pgf Developer Access: cvs -d :ext:${USER}@cvs.gentoo.org:/var/cvsroot co gentoo-x86/media-gfx/pixels2pgf More Information: http://anoncvs.gentoo.org/ ...
Elevated level of free 8-iso-prostaglandin F2alpha in the decidua basalis of women with preeclampsia. Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia
TY - JOUR. T1 - Nitric oxide in bovine corpus luteum. T2 - Possible mechanisms of action in luteolysis. AU - Korzekwa, Anna. AU - Woclawek-Potocka, Izabela. AU - Okuda, Kiyoshi. AU - Acosta, Tomas J.. AU - Skarzynski, Dariusz J.. PY - 2007/6/1. Y1 - 2007/6/1. N2 - Although prostaglandin (PG) F2α is considered as the principal luteolytic factor, its action on the bovine corpus luteum (CL) is mediated by other intraovarian factors. Among them, nitric oxide (NO) seems to play a mandatory role in luteolysis. In this article we review the background and current status of work on possible roles of NO in the CL function, based on available information and our own experimental data. NO is produced in all three main types of bovine CL cells: steroidogenic, endothelial and immune cells. PGF2α and some luteolytic cytokines (tumor necrosis factor, interferon) increase NO production and stimulate NO synthase expression in the bovine CL. NO inhibits progesterone production, stimulates the secretion of ...
Mouse 8-iso-PGF2α(8-isoprostane) ELISA Kit from ELISA Genie is a pre-coated immunoassay with a sensitivity of 9.375pg/ml and a range of 15.625-1000pg/ml and has been designed to measure Mouse 8-iso-PGF2α(8-isoprostane) ELISA Kit in serum, plasma & cell culture supernatant samples. The Mouse 8-iso-PGF2α(8-isoprostane) ELISA Kit accurately measures natural Mouse 8-iso-PGF2α(8-isoprostane) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Mouse 8-iso-PGF2α(8-isoprostane) peptide.
Isoprostanes are stable products of arachidonic acid peroxidation and are regarded as the most reliable markers of oxidative stress in vivo. Here we describe the LC-MS/MS procedure enabling simultaneous determination of four regioisomers (8-iso prostaglandin F2α, 8-iso-15(R)-prostaglandin F2α, 11β-prostaglandin F2α, 15(R)-prostaglandin F2α) in plasma samples collected from mice. The four plasma isoprostanes are determined by LC-ESI-MS/MS with deuterated 8-iso-PGF2α-d4 as an internal standard (I.S.). For plasma samples spiked with the isoprostanes at a level of 200 pg/mL each, the method imprecision has been below 7.1% and mean inaccuracy equaled 8.7%. The applicability of the proposed approach has been verified by the assessment of changes in isoprostane levels in plasma samples derived from mice exposed to tert-butyl hydroperoxide (TBHP), a model inducer of oxidative stress, or to antitumor drug doxorubicin (DOX) known for potent stimulation of redox cycling. Compared to the control group of
Oxidative stress and inflammation are supposed to be the key players of several acute and chronic diseases, and also for progressive aging process. Eicosanoids, especially prostaglandin F-2 alpha (PGF(2 alpha)) and F-2-isoprostanes are endogenous compounds that are involved both in physiology and the above mentioned pathologies. These compounds are biosynthesized mainly from esterified arachidonic acid through both enzymatic and non-enzymatic free radical-catalysed reactions in vivo, respectively. They have shown to possess potent biological activities in addition to their application as biomarkers of oxidative stress and inflammation. Recent advancement of methodologies has made it possible to quantify these compounds more reliably and apply them in various in vivo studies successfully. Today, experimental and clinical studies have revealed that both PGF(2 alpha) and F-2-isoprostanes are involved in severe acute or chronic inflammatory conditions such as rheumatic diseases, asthma, risk factors ...
TY - JOUR. T1 - The secretion of transforming growth factor-beta by bovine luteal cells in vitro. AU - Gangrade, Bhushan K.. AU - Gotcher, Elisa D.. AU - Davis, John S.. AU - May, Jeffrey V.. PY - 1993/6. Y1 - 1993/6. N2 - Transforming growth factor-beta (TGF-β), a multifunctional polypeptide growth factor, is produced by follicular cells in the ovary. However, there is little information indicating that TGF-β is produced in the post-ovulatory follicle, i.e. the corpus luteum. In the present communication we present evidence that bovine luteal cells secrete large amounts of TGF-β when maintained in moderate-term monolayer culture. Using TGF-β1 and TGF-β2 subtype-specific antibodies to neutralize the bioactivity it was found that 80-90% TGF-β activity in luteal cell conditioned medium (LCCM) is due to TGF-β1, whereas ≤ 10% TGF-β activity in LCCM is due to TGF-β2. TGF-β subtype nonspecific antibodies effectively and completely neutralized all TGF-β activity in LCCM. The ratio of ...
In Experiment 1, lactating dairy cows (n = 1,230) in 6 herds were treated with 2 injections of prostaglandin F2α(PGF2α) 14 days apart (Presynch), with the second injection administered 12 to 14 days before the onset of a timed AI protocol (Ovsynch). Cows were inseminated when detected in estrus after the Presynch PGF2αinjections. Cows not inseminated were enrolled in the Ovsynch protocol and were assigned randomly to be treated with either Estrumate or Lutalyse as part of a timed artificial insemination (AI) protocol. Blood samples were collected before treatment injection (0 hour) and 48 and 72 hours later. In cows having progesterone concentrations ≥1 ng/mL at 0 hour and potentially having a functional corpus luteum (CL) responsive to a luteolytic agent, Lutalyse increased (P | 0.05) luteal regression from 83.9 to 89.3%. Despite a significant increase in luteolysis, pregnancy rate per AI did not differ between treatments. Fertility was improved in both treatments in cows having reduced
Answer:Lutalyse is a brand name for a natural prostaglandin. There are several different prostaglandins on the market, some of which are synthetic. The synthetic ones are not used in cats since they are likely too powerful. So we only use Lutalyse, which is specifically prostaglandin F-2alpha. An alternate name for it you will sometimes see used is dinoprost tromethamine. Lutalyse is actually only labeled for use in cattle, not small animals, despite its long history of use in dogs and cats. You are going to have to indulge me in a short lesson on reproduction to explain why this drug is used differently in large animals versus cats. In cattle, it is a luteolytic agent. This means that it is able to shut down a structure on the ovary called the corpus luteum (CL). A CL forms on the ovary for every ovarian follicle that ovulates an egg. The function of the CL is to produce progesterone, which is the dominant hormone in pregnancy (and false pregnancy). So while the CLs are producing progesterone, ...
File scanned at 300 ppi (Monochrome, 256 Grayscale) using Capture Perfect 3.0.82 on a Canon DR-9080C in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR ...
Hey everyone :) Im new to the site, so it will be cool to see the stuff you guys post in the future after Christmas time. I wanted to show you...
SUGINO Norihiro , OKUDA Kiyoshi Luteolysis is defined as the loss of function and subsequent involution of the luteal structure. The luteolytic process is usually subdivided, whereby the decline in progesterone is described as funct … Journal of Reproduction and Development 53(5), 977-986, 2007-10-01 J-STAGE Ichushi Web References (65) Cited by (4) ...
With heifers given two injections of Lutalyse 11 days apart, and inseminated 80 hours after the second injection, only 20% in heat before 48 hours conceived compared with 65% that were in heat 48 to 80 hours after injection ...
中文: 经气相色谱分析PGF-为葡聚糖,PGF-、PGF- 和PGF-由葡萄糖、甘露糖和半乳糖组成,摩尔比分别为:. :.、:0. :0.和:0.:0. 8。 更详细... ...
TY - JOUR. T1 - Influence of prostaglandin F2α analogues on the secretory function of bovine luteal cells and ovarian arterial contractility in vitro. AU - Korzekwa, A. J.. AU - Lukasik, K.. AU - Pilawski, W.. AU - Piotrowska-Tomala, K. K.. AU - Jaroszewski, J. J.. AU - Yoshioka, S.. AU - Okuda, K.. AU - Skarzynski, D. J.. PY - 2014/1. Y1 - 2014/1. N2 - Although prostaglandin (PG) F2α analogues are routinely used for oestrus synchronisation in cattle, their effects on the function of the bovine corpus luteum (CL), and on ovarian arterial contractility, may not reflect the physiological effects of endogenous PGF2α. In the first of two related experiments, the effects of different analogues of PGF2α (aPGF2α) on the secretory function and apoptosis of cultured bovine cells of the CL were assessed. Enzymatically-isolated bovine luteal cells (from between days 8 and 12 of the oestrous cycle), were stimulated for 24h with naturally-occurring PGF2α or aPGF2α (dinoprost, cloprostenol or ...
TY - JOUR. T1 - Comparison of particle-associated progesterone and oxytocin in the ovine corpus luteum. AU - Rice, G. E.. AU - Jenkin, G.. AU - Thorburn, G. D.. PY - 1986/1/1. Y1 - 1986/1/1. N2 - The subcellular distribution of progesterone and oxytocin within the ovine corpus luteum was investigated using differential and density gradient centrifugation. Progesterone and oxytocin were associated with particles which sedimented to a density of 1.049-1.054 g/ml and 1.054-1.061 g/ml respectively. Particle-associated progesterone did not, however, display physical or biochemical characteristics consistent with its storage within secretory granules. When particle-associated progesterone was incubated in HEPES buffer at 37°C, 70% of the total progesterone was recovered in the incubation medium. The remaining stable particle-associated progesterone was not affected by treatments which stimulated oxytocin release and which have been shown to cause the release of peptides and biogenic amines from ...
Oxidative stress is assumed to be the key underlying factor in the pathogenesis of many common diseases. This study describes the basal levels of 8-iso-PGF(2alpha ), a major F(2)-isoprostane and an in vivo oxidative stress biomarker in healthy subjects from three countries, namely Italy, Poland and Sweden, in relation to their smoking habits, age and gender. It studied urinary 8-iso-PGF(2alpha ) in 588 subjects from Sweden (n=220), Italy (n=203) and Poland (n=165). Polish subjects had the highest levels of F(2)-isoprostanes followed by the Swedish and Italians when adjusted for smoking, age, sex and creatinine and the inter-country differences were statistically significant. Smokers had significantly higher levels of 8-iso-PGF(2alpha ) compared to non-smokers in all countries and there was a moderate decrease with age. Women had only slightly lower 8-iso-PGF(2alpha ) than men. There is a difference in F(2)-isoprostane levels in vivo between countries. Smoking, age and gender affect isoprostane ...
6-keto Prostaglandin F1alpha-d4 from Cayman Chemical,PGF1α-d4 contains 4 deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry.,biological,biology supply,biology supplies,biology product
PubMed journal article Increases in urinary 9alpha,11beta-prostaglandin f2 indicate mast cell activation in wine-induced asthm were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Ma, T.; Jiang, H.; Gao, Y.; Zhao, Y.; Dai, L.; Xiong, Q.; Xu, Y.; Zhao, Z.; Zhang, J., 2012: Microarray analysis of differentially expressed microRNAs in non-regressed and regressed bovine corpus luteum tissue; microRNA-378 may suppress luteal cell apoptosis by targeting the interferon gamma receptor 1 gene
Transforming growth factor-alpha: identification in bovine corpus luteum by immunohistochemistry and northern blot analysis Academic Article ...
Gentaur molecular products has all kinds of products like :search , Zyagen \ Bovine Corpus Luteum* cDNA \ BD-417 for more molecular products just contact us
Progesterone administered before breeding may increase estrous expression and subsequent fertility in lactating dairy cows. Holstein cows (n=302) were assigned randomly at calving to three groups. Cows received no treatment (controls), one injection of prostaglandin F 2-alpha (PGF), or progesterone plus one injection of PGF (PRID + PGF). The average interval to estrus was 5 days shorter in PRID + PGF cows compared to cows given only PGF. In addition, more cows were observed in estrus 2 to 5 days after treatment in the PRID + PGF group compared to the PGF group. Average days from calving to conception were reduced in PRID + PGF cows by 15 to 20 days compared to control and PGF cows. We concluded that prebeeding progesterone in combination with PGF appears to enhance fertility ...
A study undertaken to characterise the oestrous cycle in Zebu cows following oestrous induction with PGF (Prostaglandin F2alpha) and examines the function of the subsequently formed CL (corpus luteum) by monitoring levels of peripheral plasma progesterone ...
Creative-Proteomics offer cas 363-23-5 13,14-dihydro-15-keto Prostaglandin E2-d4. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Isoprostanes are a recently discovered group of prostaglandin isomers. Results of previous studies suggest that they can be used as oxidative stress markers, because in a number of cardiovascular, pulmonary and neurological diseases their levels in biological samples considerably increase. It...
Many dairy veterinarians prescribe the use of prostaglandin F2α (PG) in dairy herds to control time to estrus (heat), as part of synchronization programs or for postpartum treatments. There are two primary PG products available in the U.S.,
Estrumate is used as a luteolytic agent in cattle. The luteolytic action of Estrumate can be utilized to manipulate the estrous cycle to better fit certain management practices, terminal pregnancies resulting from mismatings, and to treat certain conditions associated with prolonged luteal function ...
The forum for the discussion of the use of hormones in the mare to induce estrus; maintain pregnancy; abort foals; and also use of hormones to stimulate or quieten stallions.
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions ...
Genestran 75mg/ml Solution for Injection 20ml is used to induce luteolysis in mares with functional corpus luteum. Light sweating and diarrhea
8 PROSTAGLANDIN F2a ANALOGUES 10. Ideal implantation is into the connective tissue layer between the mucosa and the rhabdospincter (24).
Thanks to the infrastructure that was developed during the Fedora 7 release cycle, Alpha is accompanied by live CDs of both the GNOME and KDE desktops, making testing possible without installing any software on an existing system. As the Alpha release is largely targeted at developers and contains many bleeding edge packages, this is the best method for less experienced users who want to get involved with testing. Alpha images can be downloaded from any of our mirrors by visiting this page . Remember that live images can be used on USB media via the livecd-iso-to-disk utility available in the livecd-tools package on existing Fedora systems; Refer to this article for more instructions. ...
Thanks to the infrastructure that was developed during the Fedora 7 release cycle, Alpha is accompanied by live CDs of both the GNOME and KDE desktops, making testing possible without installing any software on an existing system. As the Alpha release is largely targeted at developers and contains many bleeding edge packages, this is the best method for less experienced users who want to get involved with testing. Alpha images can be downloaded from any of our mirrors by visiting this page . Remember that live images can be used on USB media via the livecd-iso-to-disk utility available in the livecd-tools package on existing Fedora systems; Refer to this article for more instructions. ...
Palm has moved Ares, its Web-based development environment for WebOS applications, to an alpha release stage, a Palm official said in a blog earlier this month
The function calculates nonparametric indices for testing the validity of an ISOP-Model, suggested by Scheiblechner, for a given set of items. ...
Hi, Does anyone know how to show, by means of probability generating functions, that for large n and small p, (n →∞, p→0), such that
若手FPによる座談会 明日のFP、未来のFP像を語ろう (特集 新時代に羽ばたけ! 若手FP : 仕事のヒント・悩み・将来を共有しよう) (2019 ...
INTRODUCTION: The most recently discovered severe acute respiratory syndrome Coronavirus 2 (SARS-COV-2) that causes COVID-19, subjected the entire world in turmoil health-wise and economically. With higher burden of malaria in Nigeria and other Sub-Saharan African countries coupled with fragile healthcare system and delivery, these may pose a threat in the diagnosis and management of COVID-19 patients co-infected with malaria. Free radicals have been implicated in the progression and pathogenesis of malaria and COVID-19 through Fentons reaction and cytokine storm respectively. METHODS: the current research comprises of seventy-four (74) participants; 20 apparently healthy controls and 54 COVID-19 patients (20 among which were co-infected with malaria). Serum levels of 8-iso PGF2α and Alphatocopherol were determined among the study participants using ELISA technique and colorimetric assay, respectively. RESULTS: results revealed statistically significant elevation of 8-iso PGF2α in COVID-19 patients
The present study reveals that 15-F2t-IsoP causes greater constriction of periventricular microvessels of the fetus than of newborn and juvenile animals due to greater thromboxane generation through a previously undescribed mechanism of action of 15-F2t-IsoP, which seems to involve activation of distinct calcium channels and an interaction between vascular and perivascular cells. Data indicate that 15-F2t-IsoP elicits vasoconstriction by increasing the release of thromboxane from brain astroglial and endothelial but not vascular smooth muscle cells; the increased thromboxane synthesis seems to result from increased entry of extracellular calcium into cells, possibly through N-type voltage-dependent calcium channels in astrocytes and non-voltage-dependent calcium channels in endothelial cells.. The effects of 15-F2t-IsoP have been found to be markedly inhibited by thromboxane receptor blockers7 22 23 24 ; however, ligand binding studies suggest that 15-F2t-IsoP does not directly interact with the ...
Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed dinoprost (INN), is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. In domestic mammals, it is produced by the uterus when stimulated by oxytocin, in the event that there has been no implantation during the luteal phase. It acts on the corpus luteum to cause luteolysis, forming a corpus albicans and stopping the production of progesterone. Action of PGF2α is dependent on the number of receptors on the corpus luteum membrane. The PGF2α isoform 8-iso-PGF2α was found in significantly increased amounts in patients with endometriosis, thus being a potential causative link in endometriosis-associated oxidative stress. PGF2α acts by binding to the prostaglandin F2α receptor. It is released in response to an increase in oxytocin levels in the uterus, and stimulates both luteolytic activity and the release of oxytocin. Because PGF2α is linked with an increase in uterine ...
This study investigated whether or not there was an overall difference in the pulmonary oxidative marker, 8-isoprostane (PGF2-a), found in exhaled breath condensate, during pregnancy versus the non-pregnant state. The utility of this information was important secondary to the effect of maternal asthma on pregnancy and outcome, as it has been demonstrated in past studies that overall pregnant females with asthma have been shown to have an increased risk of exacerbation requiring medical intervention.The primary goal of this study sought to determine if there is a difference in PGF2a levels in the exhaled breath condensate of pregnant versus non-pregnant females. In order to achieve this goal a cross-sectional study was performed consisting of two groups and were compared to one another. A group of 16 healthy, non-pregnant females aged 18-35 years old was compared to a group of 6 healthy, pregnant females in their third trimester of pregnancy. Both groups exhaled breath condensate was collected and 8
TY - JOUR. T1 - Analysis of microarray data from the macaque corpus luteum; the search for common themes in primate luteal regression. AU - Bishop, C. V.. AU - Bogan, R. L.. AU - Hennebold, J. D.. AU - Stouffer, R. L.. PY - 2011/3. Y1 - 2011/3. N2 - The factors and processes involved in regression of the primate corpus luteum (CL) are complex and not fully understood. Systemic identification of those genes that are differentially expressed utilizing macaque model systems of luteal regression could help clarify some of the important molecular events involved in loss of primate luteal structure and function during luteolysis. In addition, examining gene pathways involved in luteal regression may help elucidate novel approaches for overcoming infertility or designing ovary-based contraceptives. This review provides an overview of the current published microarray experiments evaluating the transcriptome of the macaque CL, and compares and contrasts the data from spontaneous, GnRH antagonist and ...
Recent studies suggest that chemokines may mediate the luteolytic action of PGF2α (PGF). Our objective was to identify chemokines induced by PGF in vivo and to determine the effects of IL8 on specific luteal cell types in vitro. Midcycle cows were injected with saline or PGF, ovaries were removed after 0.5 - 4 h and chemokine expression was analyzed by qPCR. In vitro expression of IL8 was analyzed after PGF administration and with cell signaling inhibitors to determine the mechanism of PGF-induced chemokine expression. Purified neutrophils were analyzed for migration and activation in response to IL8 and PGF. Purified luteal cell types (steroidogenic, endothelial and fibroblast cells) were used to identify which cells respond to chemokines. Neutrophils and peripheral blood mononuclear cells (PBMCs) were co-cultured with steroidogenic cells to determine their effect on progesterone production. IL8, CXCL2, CCL2, and CCL8 transcripts were rapidly increased following PGF treatment in vivo and. The
Background: Cigarette smoking is a risk factor for several diseases including cardiovascular disease, chronic obstructive pulmonary disease and lung cancer, but the role of specific smoke constituents in these diseases has not been clearly established. Methods: The relationship between biomarkers of potential harm (BOPH), associated with inflammation [white blood cell (WBC), high sensitivity C-reactive protein (hs-CRP), fibrinogen, von Willebrand factor (vWF)], oxidative stress [8-epi-prostaglandin F2α (8-epiPGF2α)] and platelet activation -[11-dehydro-thromboxin B2 (11-dehTxB2)], and machine measured tar yields (grouped into 4 categories), biomarkers of exposure (BOE) to cigarette smoke, nicotine and five metabolites [(Nicotine equivalents) - NE)], 4-methylnitrosamino-1-(3-pyridyl)-1-butanol (total NNAL), carboxyhemoglobin (COHb), 1-hydroxypyrene (1-OHP), 3-hydroxypropylmercapturic acid (3-HPMA) and monohydroxybutenyl-mercapturic acid (MHBMA), was investigated in 3,585 adult smokers (AS) and ...
Prostaglandin F2α. Prostaglanin is a C2O fatty acid and is produced within the uterine endometrium and vesicular glands. Estradiol stimulates prostaglandin synthesis while progesterone inhibits it. The target tissue in the female is the corpus luteum, uterine myometrium and ovulatory follicles. In the female PGF2α cause luteolysis and can also cause the induction of tone and contractions within the uterus. It plays an important role in partuition in ruminants.. If a pregnancy is to remain viable then luteolysis needs to be avoided and this is achieved where concentrations of PGF2α remain below a threshold level allowing the corpus luteum to continue to secrete progesterone and thus maintain pregnancy. There are two main factors involved in the regulation of uterine secretions of PGF2α; oxytocin secretions from the corpus luteum and molecules secreted by the developing embryo that facilitate the maternal recognition of pregnancy.. Oxytocin secretion via the corpus luteum stimulates ...
The origin and physiological significance of high pulses of prostaglandin F2α (PGF2α) in uterine venous blood that occur 2-3 days after luteolysis are not well understood. We studied the relationship between contractions of the uterus evoked by exogenous oxytocin (OT) and PGF2α concentration in uterine venous blood on day 17 of the porcine oestrous cycle. The infusion of OT into the uterine artery produced an immediate increase in the uterine intraluminal pressure (UIP) (p , 0.001) and a simultaneous elevation in PGF2α concentration in uterine venous blood (p , 0.0001). The infusion of indomethacin (IND) into the uterine artery slightly decreased PGF2α concentration in uterine venous blood, but it did not suppress uterine contraction or the rapid increase in PGF2α concentration in uterine venous blood just after OT infusion (p , 0.0001), which was lower that in gilts not treated with IND. We conclude that the spikes of PGF2α concentration in uterine venous blood occurring after OT ...
Prostaglandin D2 (PGD2) was recently found to be stereospecifically converted to the compound (5Z,13E)-(15S)-9 alpha,11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-PGF2) by a human liver cytosolic NADPH-dependent 11-ketoreductase enzyme. Because PGD2 is a potent bronchoconstrictor …
In ruminants, uterine pulses of prostaglandin (PG) F 2α characterize luteolysis, while increased PGE 2 /PGE 1 distinguish early pregnancy. This study evaluated intrauterine (IU) infusions of PGF 2α and PGE 1 pulses on corpus luteum (CL) function and gene expression. Cows on day 10 of estrous cycle received 4 IU infusions (every 6 h; n = 5/treatment) of saline, PGE 1 (2 mg PGE 1), PGF 2α (0.25 mg PGF 2α), or PGE 1 + PGF 2α. A luteal biopsy was collected at 30 min after third infusion for determination of gene expression by RNA-Seq. As expected, IU pulses of PGF 2α decreased (P , 0.01) P4 luteal volume. However, there were no differences in circulating P4 or luteal volume between saline, PGE 1, and PGE 1 + PGF 2α, indicating inhibition of PGF 2α -induced luteolysis by IU pulses of PGE 1. After third pulse of PGF 2α, luteal expression of 955 genes were altered (false discovery rate [FDR] , 0.01), representing both typical and novel luteolytic transcriptomic changes. Surprisingly, after ...
In the current study, our results demonstrated that the IκB/NF-κB signaling pathway was involved in the expression and activation of MMP-2 in human ciliary muscle cells. Downregulation of IκBα by siRNA resulted in significant translocation of NF-κBp65 from the cytoplasm to the nucleus after 24 h to 72 h. The secretion of MMP-2 increased as well as the activation from pro-MMP-2 to active-MMP-2. In addition, the expression of MT1-MMP increased while the expression of TIMP-2 reduced both in mRNA and protein levels. It is implied from these results that NF-κB is an important transcriptional factor involved in the control of uveoscleral outflow through the promotion of MMP-2 expression. It has been reported that NF-κB is involved in various activities and plays a key role in multiple biological processes including chemical stress, physical stress, physiologic stress, receptor ligands, proinflammatory cytokines, and apoptosis. At the same time, there are also multiple and complex signal ...
A synthetic analogue of the naturally occurring prostaglandin F2 alpha. Prostaglandin F2 alpha stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum. (NCI04)
TY - JOUR. T1 - Dynamic changes in gene expression that occur during the period of spontaneous functional regression in the rhesus macaque corpus luteum. AU - Bogan, Randy L.. AU - Murphy, Melinda J.. AU - Hennebold, Jon D.. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2009/3. Y1 - 2009/3. N2 - Luteolysis of the corpus luteum (CL) during nonfertile cycles involves a cessation of progesterone (P4) synthesis (functional regression) and subsequent structural remodeling. The molecular processes responsible for initiation of luteal regression in the pri mate CL are poorly defined. Therefore, a genomic approach was used to systematically identify differentially expressed genes in the rhesus macaque CL during spontaneous luteolysis. CL were collected before [d 10-11 after LH surge, mid-late (ML) stage] or during (d 14-16, late stage) functional regression. Based on P4 levels, late-stage CL were subdivided into functional-late (serum P4 , 1.5 ng/ml) and functionally regressed ...
Endometrial cells from the uteri of pregnant and nonpregnant cattle were cultured. The presence of one or both of two viruses, noncytopathic mucosal disease virus and bovine syncytial virus, was demonstrated in seven of 19 endometria investigated. It was necessary to subculture the cells an average of four times to detect the viral infections. Difficulties were encountered in producing endometrial cell cultures from cows at term or near the end of term and also from older animals. The infections detected may be significant because both of the viruses isolated are capable of infecting the bovine fetus in utero and mucosal disease virus has been associated with bovine fetal diseases.
Definition of f2-isoprostanes in the Definitions.net dictionary. Meaning of f2-isoprostanes. What does f2-isoprostanes mean? Information and translations of f2-isoprostanes in the most comprehensive dictionary definitions resource on the web.
We investigated whether an EPA-enriched high-fat meal could improve postprandial vascular function. Seventeen healthy men ingested 2 test meals (51 g fat), 1 wk apart, in random order: 5 g EPA plus high-oleic sunflower oil (HOS) vs. HOS only. A second high-fat meal (44 g fat), the same on both study days, was provided 4 h later. Blood pressure and arterial function were measured using digital volume pulse (DVP) to derive a stiffness index (DVP-SI) and reflection index in fasting subjects at 3 and 6 h following the test meal. Blood samples were taken following the test meal for plasma 8-isoprostane F2alpha, nitric oxide (NO) metabolites (NOx), glucose, insulin, triacylglycerol, and fatty acid analysis ...
Sboros V, Averkiou M, Lampaskis M, et al. Imaging of the Ovine Corpus Luteum Microcirculation with Contrast Ultrasound. Ultrasound in Medicine & Biology. 2011;37:59-68. doi:10.1016/j.ultrasmedbio.2010.10.013 ...
Sotiris, A. and Prokopiou, S. A. and Byrne, H. M. and Jeffrey, M. R. and Robinson, R. S. and Mann, G. E. and Owen, M. R. (2013) Mathematical analysis of a model for the growth of the bovine corpus luteum. Journal of Mathematical Biology . (Submitted) ...
A ABKIT oferece uma linha completa de anticorpos, kits de ELISA, proteínas e equipamentos para pesquisa científica incluindo Câncer e Apoptose, Citosinas Inflamatórias, Hormônios, Metabolismo, Neurociência, Segurança Alimentar, Stress Oxidativo e Testes S
Number of bootstrap samples: This number determines the bootstrap sample; a larger number will give more accurate results but will take longer to compute.. All other parameters should not need to be changed under normal use.. Once all files are loaded and the desired settings entered into the program, press Run model. Your result will be presented in three tabs which can be selected from the top menu and consist of 3 graphs (Figures), 5 tables (Tables), and two datasets (Data subset, and Full dataset) where all computed and entered values can be viewed for quality control or troubleshooting. Figure 4 shows a typical output window.. ...
Oxytocin (a hormone that stimulates contractions during labor) is usually injected intramuscularly to aid the expulsion of the placenta after the baby comes out. That is if the mother is too weak to push. But heres something else that works, BREASTFEEDING.
Dropbox is a free service that lets you bring your photos, docs, and videos anywhere and share them easily. Never email yourself a file again!
"LUTALYSE® Injection (dinoprost injection)". www.zoetisus.com. Retrieved 2021-04-06. "Hormonal Control of Estrus in Cattle - ...
Dinoprost: also known as PGF 2α, is a naturally occurring prostaglandin which causes contraction via PG F receptors. Dinoprost ...
"Dinoprost tromethamine Injection Advanced Patient Information". Truvn Health Analytics Inc. 2016. Retrieved November 2, 2017. ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
... , as a lipophilic ester, easily penetrates the cornea and is then activated to the carboxylic acid, tafluprost acid. Onset of action is 2 to 4 hours after application, the maximal effect is reached after 12 hours, and ocular pressure remains lowered for at least 24 hours.[2][3] Tafluprost acid is inactivated by beta oxidation to 1,2-dinortafluprost acid, 1,2,3,4-tetranortafluprost acid, and its lactone, which are subsequently glucuronidated or hydroxylated. The cytochrome P450 liver enzymes play no role in the metabolism.[3] An analogous pathway (at least up to the tetranor-metabolites) has been found for latanoprost and travoprost. ...
It is believed that the vasoconstriction caused by thromboxanes plays a role in Prinzmetal's angina. Omega-3 fatty acids are metabolized to produce higher levels of TxA,3 which is relatively less potent than TxA2 and PGI3; therefore, there is a balance shift toward inhibition of vasoconstriction and platelet aggregation. It is believed that this shift in balance lowers the incidence of myocardial infarction (heart attack) and stroke. Vasoconstriction and, perhaps, various proinflammatory effects exerted by TxA on tissue microvasculature, is probable reason why the TxA is pathogenic in various diseases, such as ischemia-reperfusion injury.,[2] hepatic inflammatory processes,[3] acute hepatotoxicity [4] etc. TxB2, a stable degradation product of TxA2, plays a role in acute hepatoxicity induced by acetaminophen.[5][6] ...
The US National Institute of Health's MedlinePlus lists medical conditions for which EPA (alone or in concert with other ω-3 sources) is known or thought to be an effective treatment.[18] Most of these involve its ability to lower inflammation. Intake of large doses (2.0 to 4.0 g/day) of long-chain omega-3 fatty acids as prescription drugs or dietary supplements are generally required to achieve significant (, 15%) lowering of triglycerides, and at those doses the effects can be significant (from 20% to 35% and even up to 45% in individuals with levels greater that 500 mg/dL). It appears that both EPA and DHA lower triglycerides; however, DHA appears to raise low-density lipoprotein (the variant which drives atherosclerosis, sometimes inaccurately called "bad cholesterol") and LDL-C values (always only a calculated estimate; not measured by labs from person's blood sample for technical and cost reasons), while EPA does not. EPA and DHA ethyl esters (all forms) may be absorbed less well, thus ...
Leukotriene B4 (i.e. LTB4) is an arachidonic acid metabolite made by the 5-lipoxygenase enzyme pathway. It activates cells through both its high affinity (Dissociation constant [Kd] of 0.5-1.5 nM) Leukotriene B4 receptor 1 (BLT1 receptor) and its low affinity BLT2 receptor (Kd=23 nM); both receptors are G protein coupled receptors that, when ligand-bound, activate cells by releasing the Gq alpha subunit and pertussis toxin-sensitive Gi alpha subunit from Heterotrimeric G proteins.[19][20] BLT1 receptor has a high degree of ligand-binding specificity: among a series of hydroxylated eicosanoid metabolites of arachidonic acid, it binds only LTB4, 20-hydroxy-LTB4, and 12-epi-LTB4; among this same series, BLT2 receptor has far less specificity in that it binds not only LTB4, 20-hydroxy-LTB4, and 12-epi-LTB4 but also 12(R)-HETE and 12(S)-HETE (i.e. the two stereoisomers of 12-Hydroxyeicosatetraenoic acid) and 15(S)-HpETE and 15(S)-HETE (i.e. the two stereoisomers of 15-Hydroxyicosatetraenoic ...
The drug is clear with a pH of 10.[7] Its production is inhibited indirectly by NSAIDs, which inhibit the cyclooxygenase enzymes COX1 and COX2. These convert arachidonic acid to prostaglandin H2 (PGH2), the immediate precursor of prostacyclin. Since thromboxane (an eicosanoid stimulator of platelet aggregation) is also downstream of COX enzymes, one might think that the effect of NSAIDs would act to balance. However, prostacyclin concentrations recover much faster than thromboxane levels, so aspirin administration initially has little to no effect but eventually prevents platelet aggregation (the effect of prostaglandins predominates as they are regenerated). This is explained by understanding the cells that produce each molecule, TXA2 and PGI2. Since PGI2 is primarily produced in a nucleated endothelial cell, the COX inhibition by NSAID can be overcome with time by increased COX gene activation and subsequent production of more COX enzymes to catalyze the formation of PGI2. In contrast, TXA2 is ...
... supplementation in daily doses of 1,000-1,500 mg for 50 days has been well tolerated during several clinical studies, with no significant side effects reported. All common markers of health, including kidney and liver function,[35] serum lipids,[39] immunity,[40] and platelet aggregation[34] appear to be unaffected with this level and duration of use. Furthermore, higher concentrations of ARA in muscle tissue may be correlated with improved insulin sensitivity.[41] Arachidonic acid supplementation of the diets of healthy adults appears to offer no toxicity or significant safety risk. While studies looking at arachidonic acid supplementation in sedentary subjects have failed to find changes in resting inflammatory markers in doses up to 1,500 mg daily, strength-trained subjects may respond differently. One study reported a significant reduction in resting inflammation (via marker IL-6) in young men supplementing 1,000 mg/day of arachidonic acid for 50 days in combination with ...
Alprostadil is sold in the United States as urethral suppositories and in injectable form. The suppositories are sold under the brand name Muse.[6] The injectable forms are Edex[7] and Caverject.[8] Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection is needed. Caverject and Edex are similarly fast-acting, but instead are injected by syringe directly into the corpus cavernosum of the penis. Alprostadil is also available as a generic. The major cost is that it must be mixed by a compounding pharmacy and supplies may be difficult to obtain. The different formulations, including Bimix and Trimix, may include papaverine and/or phentolamine. A typical mix might be 30 mg of papaverine, 2 mg of phentolamine, and 20 μg alprostadil. As a generic, it is much less expensive than the packaged injectables. It is premixed and must be kept refrigerated and the user must load a syringe with the quantity needed. Most recently, the compound has ...
Both COX1 and COX2 (also termed prostaglandin-endoperoxide synthase-1 (PTGS1) and PTGS2, respectively) metabolize arachidonic acid by adding molecular O2 between carbons 9 and 11 to form an endoperoxide bridge between these two carbons, adding molecular O2 to carbon 15 to yield a 15-hydroperoxy product, creating a carbon-carbon bond between carbons 8 and 12 to create a cyclopentane ring in the middle of the fatty acid, and in the process making PGG2, a product that has two fewer double bonds than arachidonic acid. The 15-hydroperoxy residue of PGG2 is then reduced to a 15-hydroxyl residue thereby forming PGH2. PGH2 is the parent prostanoid to all other prostanoids. It is metabolized by (see diagram in Prostanoids: a) the Prostaglandin E synthase pathway in which any one of three isozymes, PTGES, PTGES2, or PTGES3, convert PGH2 to PGE2 (subsequent products of this pathway include PGA2 and PGB2 (see Prostanoid#Biosynthesis); b) PGF synthase which converts PGH2 to PGF2α; c) Prostaglandin D2 ...
Prostaglandin F2α (PGF2α u prostanoidnoj nomenklaturi), farmaceutski naziv dinoprost (INN), prirodni prostaglandin koji se ...
F2α (Dinoprost): Bimatoprost · Karboprost · Latanoprost · Tafluprost · Travoprost · Unoproston. I. I2 (Prostaciklin/ ...
F2α (Dinoprost): Bimatoprost · Karboprost · Latanoprost · Tafluprost · Travoprost · Unoproston. I. I2 (Prostaciklin/ ...
F2α (Dinoprost): Bimatoprost • Karboprost • Latanoprost • Tafluprost • Travoprost • Unoproston. I. I2 (Prostaciklin/ ...
F2α (Dinoprost): Bimatoprost • Karboprost • Latanoprost • Tafluprost • Travoprost • Unoproston. I. I2 (Prostaciklin/ ...
F2α (Dinoprost): Bimatoprost • Karboprost • Latanoprost • Tafluprost • Travoprost • Unoproston. I. I2 (Prostaciklin/ ...
വിവരങ്ങൾ ക്രിയേറ്റീവ് കോമൺസ് ആട്രിബ്യൂഷൻ-ഷെയർഎലൈക്ക് അനുമതിപത്ര പ്രകാരം ലഭ്യമാണ്; മേൽ നിബന്ധനകൾ ഉണ്ടായേക്കാം. കൂടുതൽ വിവരങ്ങൾക്ക് ഉപയോഗനിബന്ധനകൾ കാണുക ...
... dinoprost (INN) dinoprostone (INN) dinsed (INN) diodone (INN) Dionosil Aqueous diosmin (INN) Diovan dioxadilol (INN) dioxadrol ...
... dinoprost MeSH D10.251.355.255.550.400.350 - 6-ketoprostaglandin f1 alpha MeSH D10.251.355.255.550.550 - prostaglandins i MeSH ... dinoprost MeSH D10.251.355.255.100.637.400.350 - 6-ketoprostaglandin f1 alpha MeSH D10.251.355.255.100.637.550 - prostaglandins ...
... combinations G02AC01 Methylergometrine and oxytocin QG02AC90 Ergometrine and oxytocin G02AD01 Dinoprost G02AD02 Dinoprostone ...
... dinoprost MeSH D23.469.050.175.725.790.450 - 6-ketoprostaglandin f1 alpha MeSH D23.469.050.175.725.895 - prostaglandins i MeSH ...
InChI=1S/C26H32N4O4S/c1-20(2)30(16-10-11-17-34-19-24(31)29-35(3,32)33)23-18-27-25(21-12-6-4-7-13-21)26(28-23)22-14-8-5-9-15-22/h4-9,12-15,18,20H,10-11,16-17,19H2,1-3H3,(H,29,31) ...
In the US, ketorolac is the only widely available intravenous NSAID. An IV form of paracetamol, which is not an NSAID, became available in Europe in 2009 and then in the US.[13] The Syntex company, of Palo Alto, California developed the ophthalmic solution Acular[25] around 2006, which is currently licensed by Allergan, Inc.[26][27] In 2007, there were concerns about the high incidence of reported side effects. This led to restriction in its dosage and maximum duration of use. In the UK, treatment was initiated only in a hospital, although this was not designed to exclude its use in prehospital care and mountain rescue settings.[1] Dosing guidelines were published at that time.[28] Concerns over the high incidence of reported side effects with ketorolac trometamol led to its withdrawal (apart from the ophthalmic formulation) in several countries, while in others its permitted dosage and maximum duration of treatment have been reduced. From 1990 to 1993, 97 reactions with a fatal outcome were ...
... , also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease.[2] It is generally used for mildly to moderately severe disease.[2] It is taken by mouth or rectally.[2] The formulations which are taken by mouth appear to be similarly effective.[3] Common side effects include headache, nausea, abdominal pain, and fever.[2] Serious side effects may include pericarditis, liver problems, and kidney problems.[2][3] Use in pregnancy and breastfeeding appears safe.[3] In people with a sulfa allergy certain formulations may result in problems.[2] Mesalazine is an aminosalicylate and anti-inflammatory.[2][3] It works by direct contact with the intestines.[2] Mesalazine was approved for medical use in the United States in 1987.[2][4] It is available as a generic medication and sold under many brand names worldwide.[5][2] A month supply in the United Kingdom costs the NHS about £43 as of ...
... is an organic compound, which, especially in its ester form, is called fenamate.[1]:458 serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. These drugs are commonly referred to as "anthranilic acid derivatives" or "fenamates" because fenamic acid is a derivative of anthranilic acid.[2]:235[3]:17[2] ...
... (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.[1] ...
The VIGOR (Vioxx GI Outcomes Research) study, conducted by Bombardier, et al., which compared the efficacy and adverse effect profiles of rofecoxib and naproxen, had indicated a significant 4-fold increased risk of acute myocardial infarction (heart attack) in rofecoxib patients when compared with naproxen patients (0.4% vs 0.1%, RR 0.25) over the 12-month span of the study. The elevated risk began during the second month on rofecoxib. There was no significant difference in the mortality from cardiovascular events between the two groups, nor was there any significant difference in the rate of myocardial infarction between the rofecoxib and naproxen treatment groups in patients without high cardiovascular risk. The difference in overall risk was by the patients at higher risk of heart attack, i.e. those meeting the criteria for low-dose aspirin prophylaxis of secondary cardiovascular events (previous myocardial infarction, angina, cerebrovascular accident, transient ischemic attack, or coronary ...
1.3 micrograms of dinoprost tromethamine is equivalent to 1 micrograms of dino-prost. Dinoprost tromethamine may also be known ... Dinoprost Tromethamine for injection, equivalent to 5 mg/ml of dinoprost in 10 ml and 30 ml vials; Lutalyse® (Upjohn); (Rx) ... Drug Interactions - Other oxytocic agents activity may be enhanced by dinoprost. Reduced effect of dinoprost would be expected ... On last day, also give dinoprost (dose not noted, but suggest using same dose as "1" above). Perform AI on alternate days after ...
LUTALYSE® Injection (dinoprost tromethamine injection) is the most "veterinarian recommended" and "producer used" prostaglandin ...
dinoprost tromethamine injection). Most-used prostaglandin in the market1. LUTALYSE® Injection (dinoprost tromethamine ...
Categories: MEDICINES STARTING WITH LETTER D, PERSONALISED MEDICAL TREATMENTS WITH INDIVIDUAL MEDICINES Tag: DINOPROST ...
Dinoprost 2.. Chemicals ← Biological Factors ← Inflammation Mediators ← Autacoids ← Eicosanoids ← Prostaglandins ← ...
dinoprost tromethamine. Known as: prostaglandin F2alpha tromethamine, PGF2alpha THAM, Prostaglandin F2-alpha THAM Expand. ...
Dinoprost Tromethamine containing medications, indications and usages, combinations with ingredients and trade names, index ... Can i drive or operate heavy machine after consuming Dinoprost Tromethamine?. Depending on the reaction of the Dinoprost ... Dinoprost Tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or prostaglandin F2 alpha tromethamine.. ... Dinoprost Tromethamine available forms, composition, doses:. *N/A Indications and Usages:. ATC codes: *N/A ICD-10 codes: *N/A ...
Dinoprost is used to cause abortion during the second trimester of pregnancy. It may also be used for other purposes as ... Lung disease Dinoprost may cause narrowing of the blood vessels in the lungs or narrowing of the lung passages ... Liver disease (or history of) The body may not get dinoprost out of the bloodstream at the usual rate, which may make the ... Dinoprost is to be administered only by or under the immediate care of your doctor. ...
dinoprost. (redirected from prostaglandin F2alpha). Also found in: Wikipedia. dinoprost. [di´no-prost] name given to ... dinoprost. /di·no·prost/ (di´no-prost) name for prostaglandin F when used as a pharmaceutical; used as the base or the ... dinoprost. prostaglandin F2α stimulates contraction of the myometrium and luteolysis. Used as the tromethamine and administered ... a href=https://medical-dictionary.thefreedictionary.com/prostaglandin+F2alpha,dinoprost,/a,. *Facebook ...
"Dinoprost tromethamine Injection Advanced Patient Information". Truvn Health Analytics Inc. 2016. Retrieved November 2, 2017.. ... This article is about the pharmaceutical agent dinoprost. For the drug dinoprostone, see Prostaglandin E2. ...
79 FR 64114 - New Animal Drugs; Alfaxalone; Dinoprost; Ivermectin and Clorsulon; Nitrofurazone; Trenbolone and Estradiol ...
79 FR 64114 - New Animal Drugs; Alfaxalone; Dinoprost; Ivermectin and Clorsulon; Nitrofurazone; Trenbolone and Estradiol ... 79 FR 44277 - New Animal Drugs; Bacitracin Methylene Disalicylate; Dinoprost Solution; Gonadorelin Hydrochloride; Progesterone ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
Acute intermittent porphyria (AIP) is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.
Dinoprost / metabolism * Dinoprostone / metabolism * Dyspepsia / etiology* * Dyspepsia / metabolism * Endoscopy, Digestive ...
Dinoprost Diphenoxylate HCl Dipyridamole [Disopyramide] Domperidone Doxorubicin HCl Droperidol [Estazolam] Ethacrynic acid ...
Dinoprost / biosynthesis* * Dinoprostone / biosynthesis* * Disease Models, Animal * Enzyme Inhibitors / pharmacology * Female * ...
Effect of single treatment with cloprostenol or dinoprost on estrus and reproductive performance in anestrous dairy cows after ...
2918 19 99 90 ????????? ?????????? Dinoprost tromethamine 2918 19 99 90 ????????? ????????? Dinoprost tromethamine 2918 90 90 ...
2918 19 99 90 ????????? ?????????? Dinoprost tromethamine 2918 19 99 90 ????????? ????????? Dinoprost tromethamine 2918 90 90 ...
DB01160 Dinoprost Tromethamine. DB00917 Dinoprostone. DB00695 Furosemide. DB03581 Glucose-6-Phosphate. DB02263 Glyceraldehyde-3 ... DB01160 Dinoprost Tromethamine. DB00917 Dinoprostone. DB00695 Furosemide. DB03581 Glucose-6-Phosphate. DB02263 Glyceraldehyde-3 ...
DB01160 Dinoprost Tromethamine. DB00654 Latanoprost. DB08819 Tafluprost. DB00287 Travoprost. IUPHAR/BPS Guide to PHARMACOLOGY ...
"LUTALYSE® Injection (dinoprost injection)". www.zoetisus.com. Retrieved 2021-04-06. "Hormonal Control of Estrus in Cattle - ...
Dinoprost. Approved, Investigational. *MalaCards. *Medline Plus. Pharma. Target, agonist. 15. Dinoprostone. Approved. * ...
Dinoprost. Edema / physiopathology*. Female. Hindlimb / blood supply. Indomethacin / pharmacology. Norepinephrine / ...
Dinoprost: also known as PGF 2α, is a naturally occurring prostaglandin which causes contraction via PG F receptors. Dinoprost ...
Dinoprost / metabolism. Dinoprostone / metabolism. Endometrium / metabolism*, physiopathology. Estrous Cycle / genetics. Female ...
dinoprost. 59. hexoprenalin. 60. finasterid. 61. alfuzosin. 62. vasopresin. 63. oxytocin. 64. dexamethazon. 65. prednison. 66. ... dinoprost. 59. hexoprenaline. 60. finasteride. 61. alfuzosin. 62. vasopresin. 63. oxytocin. 64. dexamethasone. 65. prednisone. ...
Lutalyse® Injection or Lutalyse® HighCon Injection (dinoprost tromethamine injection). cloprostenol sodium. Estrumate® ( ...
Lutalyse® Injection or Lutalyse® HighCon Injection (dinoprost tromethamine injection). cloprostenol sodium. Estrumate® ( ...
  • Prostaglandin F2α (dinoprost) and prostaglandin E2 (dinoprostone) possess expressed influence on contractility of myometrium. (wikiversity.org)
  • Since dinoprostone, like dinoprost, is metabolized rapidly, discontinuing administration of the drug and supportive therapy are usually adequate treatments for serious adverse effects. (wikiversity.org)
  • Chemistry - The tromethamine (THAM) salt of the naturally occurring prostaglandin F 2 alpha , dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder with a melting point of about 100°C. One gram is soluble in about 5 ml of water. (elephantcare.org)
  • LUTALYSE ® Injection ( dinoprost tromethamine injection ) is the most "veterinarian recommended" and "producer used" prostaglandin in the market. (zoetisus.com)
  • LUTALYSE® Injection ( dinoprost tromethamine injection ) is the most used prostaglandin in the market. (zoetisus.com)
  • The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, Dinoprost Tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. (sdrugs.com)
  • Dinoprost Tromethamine is the tromethamine (THAM) salt of the naturally occurring prostaglandin F2alpha. (sdrugs.com)
  • Prostaglandin F 2α ( PGF 2α u prostanoidnoj nomenklaturi), farmaceutski naziv dinoprost ( INN ), prirodni prostaglandin koji se koristi u medicini za indukciju porođaja, i kao abortifacijent . (wikipedia.org)
  • Although similar in structure to enzymatically synthesized prostaglandin F2alpha (DINOPROST), they occur through non-enzymatic oxidation of cell membrane lipids. (definitions.net)
  • In conjunction with the 6 th dose of FOLLTROPIN ® , administer an FDA-approved prostaglandin product (cloprostenol sodium or dinoprost tromethamine) for cattle, using the labeled dosage and administration instructions to cause luteolysis and induce estrus. (nih.gov)
  • Lutalyse Sterile Solution is supplied at a concentration of 5 mg dinoprost per ml. (valleyvet.com)
  • Lutalyse HighCon Injection is a more concentrated form of Lutalyse dinoprost injection for cattle. (valleyvet.com)
  • There are two primary PG products available in the U.S., dinoprost tromethamine (Lutalyse and generic ProstaMate) and cloprostenol sodium (Estrumate and generic estroPLAN). (progressivedairy.com)
  • All the animals were treated with two injections of Lutalyse (Dinoprost thromithamine) 25 mg each intramuscularly at 11 days apart. (veterinaryworld.org)
  • Completing the range of prostaglandins are: Enzaprost ® T (Dinoprost) and Alfabedyl ® (Alfaprostol) which allow farrowing synchronization and prevention of endometritis postpartum. (thepigsite.com)
  • The effect of intramuscular injection of dinoprost or gonadotropin-releasing hormone in dairy cows on beef quality. (tamu.edu)
  • 2004. The effect of cloprostenol or dinoprost, administered at two different sites, on the expression of estrus in postpartum dairy cattle. (iastate.edu)
  • Heifers were assigned to the PGF2alfa (CLO: cloprostenol sodium or DIN: dinoprost thromethamine) and estrus detection (AED: automated estrus detection or VSI: visual detection of estrus) treatments in a 2 x 2 factorial design. (ufl.edu)
  • In cattle, the serum half-life of dinoprost has been stated to be only "minutes" long. (elephantcare.org)
  • In swine, dinoprost should not be administered prior to 3 days of normal predicted farrowing as increased neonatal mortality may result. (elephantcare.org)
  • Preparations and dosage: dinoprost 4 mg enteric coated tablets. (bigsurlandtrust.org)
  • phenytoin in the hands, preparations and dosage: dinoprost 7 mg of nitrofurantoin once daily from 8th to the stomach. (dsaj.org)
  • In another study, cloprostenol induced a faster decrease in progesterone during the first 12 hours after injection compared to dinoprost. (progressivedairy.com)
  • hormone (Dinoprost) to induce farrowing and reduce the weaning to oestrus interval (WOI) and weaning to fertile service interval (WFSI) in sows. (thepigsite.com)
  • Although not approved, dinoprost is used also in sheep and goat reproductive medicine. (elephantcare.org)
  • According to the manufacturer, dinoprost is contraindicated in mares with acute or subacute disorders of the vascular system, GI tract, respiratory system or reproductive tract. (elephantcare.org)
  • Dinoprost is used to cause abortion during the second trimester of pregnancy. (adam.com)
  • In a study published last year, 25 mg (5 ml) dinoprost and 500 μg (2 ml) cloprostenol performed the same in lactating dairy cows when it came to the percentage of cows with complete CL regression by 56 hours after treatment. (progressivedairy.com)
  • DINOPROST TROMETHAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. (sdrugs.com)
  • Henan Newland Pharmaceutical Co., Ltd was founded by share holders of natural person in Sep.2005.Our company successively passed certifications of ISO9001:2000, BS EN ISO 14001:2004 and OHSAS 18001:1999 through Moddy International Certification ltd. (chemindustry.com)
  • Dinoprost is contraindicated in animals with bronchoconstrictive respiratory disease ( e.g., asthma, "heavey" horses). (elephantcare.org)
  • Pharmacokinetics - In studies done in rodents, dinoprost was demonstrated to distribute very rapidly to tissues after injection. (elephantcare.org)
  • Dinoprost should be used with extreme caution, if at all, in dogs or cats greater than 8 years old, or with preexisting cardiopulmonary or other serious disease (liver, kidney, etc. (elephantcare.org)
  • Depending on the reaction of the Dinoprost Tromethamine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Dinoprost Tromethamine not safe to drive or operate heavy machine after consumption. (sdrugs.com)
  • The solution to this problem may come from a study by Milo Wiltbank's lab at the University of Wisconsin - Madison in which cows were administered dinoprost at the final PG dose of the Double-Ovsynch program, and then half of the cows received a second dinoprost 24 hours later. (progressivedairy.com)
  • It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Dinoprost Tromethamine consumers. (sdrugs.com)
  • Unlabeled uses of dinoprost include its use in small animals as an abortifacient agent and as adjunctive medical therapy in pyometra. (elephantcare.org)
  • sdrugs.com conducted a study on Dinoprost Tromethamine, and the result of the survey is set out below. (sdrugs.com)
  • Cloprostenol has a longer half-life than dinoprost, and thus is maintained in circulation for a longer time. (progressivedairy.com)