Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.Methionine Sulfoxide Reductases: Reductases that catalyze the reaction of peptide-L-methionine -S-oxide + thioredoxin to produce peptide-L-methionine + thioredoxin disulfide + H(2)O.Cryoprotective Agents: Substances that provide protection against the harmful effects of freezing temperatures.Leukemia, Erythroblastic, Acute: A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.Oxidoreductases: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)DimethylformamideSolvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Iron-Sulfur Proteins: A group of proteins possessing only the iron-sulfur complex as the prosthetic group. These proteins participate in all major pathways of electron transport: photosynthesis, respiration, hydroxylation and bacterial hydrogen and nitrogen fixation.Sulfoxides: Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)Ethylene Glycol: A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.Hydroxides: Inorganic compounds that contain the OH- group.Cryopreservation: Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.Friend murine leukemia virus: A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) producing leukemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects DBA/2 and Swiss mice.Leukemia, Experimental: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.Sulfuric Acid Esters: Organic esters of sulfuric acid.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Rhodobacter sphaeroides: Spherical phototrophic bacteria found in mud and stagnant water exposed to light.Freezing: Liquids transforming into solids by the removal of heat.Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.Kinetics: The rate dynamics in chemical or physical systems.Dimethyl Suberimidate: The methyl imidoester of suberic acid used to produce cross links in proteins. Each end of the imidoester will react with an amino group in the protein molecule to form an amidine.Acetamides: Derivatives of acetamide that are used as solvents, as mild irritants, and in organic synthesis.Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).Sulfides: Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.Pteridines: Compounds based on pyrazino[2,3-d]pyrimidine which is a pyrimidine fused to a pyrazine, containing four NITROGEN atoms.Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.Formamides: A group of amides with the general formula of R-CONH2.Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Cell Line: Established cell cultures that have the potential to propagate indefinitely.Anaerobiosis: The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Free Radicals: Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.Butyrates: Derivatives of BUTYRIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxypropane structure.Acetonitriles: Compounds in which a methyl group is attached to the cyano moiety.Glycerol: A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.Dimethyl Adipimidate: Bifunctional cross-linking agent that links covalently free amino groups of proteins or polypeptides, including those in cell membranes. It is used as reagent or fixative in immunohistochemistry and is a proposed antisickling agent.Diapause, Insect: Seasonal suspension of insect growth development. It can be either induced by environmental cues (e.g., PHOTOPERIOD) or as a facultative part of the life cycle in order to time development with seasonal changes.Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.94. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. (From Dorland, 27th ed)Tungsten Compounds: Inorganic compounds that contain tungsten as an integral part of the molecule.Tissue Preservation: The process by which a tissue or aggregate of cells is kept alive outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).Leukemia, Promyelocytic, Acute: An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.Shewanella putrefaciens: A species of SHEWANELLA noted for its ability to reduce iron and manganese anaerobically.Fenthion: Potent cholinesterase inhibitor used as an insecticide and acaricide.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Benzidines: Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.MethylaminesTumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.HL-60 Cells: A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.Coenzymes: Small molecules that are required for the catalytic function of ENZYMES. Many VITAMINS are coenzymes.Erythropoiesis: The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.Diamines: Organic chemicals which have two amino groups in an aliphatic chain.Hair Cells, Ampulla: Sensory cells in the ampullary crest of each of the semicircular ducts, with their apical STEREOCILIA embedded in a wedge-shaped gelatinous cupula. These hair cells sense the movement of ENDOLYMPH resulting from angular acceleration of the head, and send signals via the VESTIBULAR NERVE to the brain to maintain balance.Globins: A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Granulocytes: Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.Metalloproteins: Proteins that have one or more tightly bound metal ions forming part of their structure. (Dorland, 28th ed)16,16-Dimethylprostaglandin E2: A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors.Tungsten: Tungsten. A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. It is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.Acetone: A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.Ethylene Glycols: An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.Pterins: Compounds based on 2-amino-4-hydroxypteridine.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Hemin: Chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N(21),N(22),N(23),N(24)) ferrate(2-) dihydrogen.Shewanella: A genus of gram-negative, facultatively anaerobic rods. It is a saprophytic, marine organism which is often isolated from spoiling fish.Geotrichosis: Infection due to the fungus Geotrichum.Free Radical Scavengers: Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Hydrogen Peroxide: A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Electron Spin Resonance Spectroscopy: A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.

Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells. (1/2132)

CTCF is a transcriptional repressor of the c-myc gene. Although CTCF has been characterized in some detail, there is very little information about the regulation of CTCF activity. Therefore we investigated CTCF expression and phosphorylation during induced differentiation of human myeloid leukemia cells. We found that: (i) both CTCF mRNA and protein are down-regulated during terminal differentiation in most cell lines tested; (ii) CTCF down-regulation is retarded and less pronounced than that of c-myc; (iii) CTCF protein is differentially phosphorylated and the phosphorylation profiles depend on the differentiation pathway. We concluded that CTCF expression and activity is controlled at transcriptional and post-transcriptional levels.  (+info)

Inhibition of aberrant proliferation and induction of apoptosis in HER-2/neu oncogene transformed human mammary epithelial cells by N-(4-hydroxyphenyl)retinamide. (2/2132)

Epithelial cells from non-cancerous mammary tissue in response to exposure to chemical carcinogens or transfection with oncogenes exhibit hyperproliferation and hyperplasia prior to the development of cancer. Aberrant proliferation may, therefore, represent a modifiable early occurring preneoplastic event that is susceptible to chemoprevention of carcinogenesis. The synthetic retinoid N-(4-hydroxyphenyl)retinamide (HPR), has exhibited preventive efficacy in several in vitro and in vivo breast cancer models, and represents a promising chemopreventive compound for clinical trials. Clinically relevant biochemical and cellular mechanisms responsible for the chemopreventive effects of HPR, however, are not fully understood. Experiments were performed on preneoplastic human mammary epithelial 184-B5/HER cells derived from reduction mammoplasty and initiated for tumorigenic transformation by overexpression of HER-2/neu oncogene, to examine whether HPR inhibits aberrant proliferation of these cells and to identify the possible mechanism(s) responsible for the inhibitory effects of HPR. Continuous 7-day treatment with HPR produced a dose-dependent, reversible growth inhibition. Long-term (21 day) treatment of 184-B5/HER cells with HPR inhibited anchorage-dependent colony formation by approximately 80% (P < 0.01) relative to that observed in the solvent control. A 24 h treatment with cytostatic 400 nM HPR produced a 25% increase (P = 0.01) in G0/G1 phase, and a 36% decrease (P = 0.01) in S phase of the cell cycle. HPR treatment also induced a 10-fold increase (P = 0.02) in the sub-G0 (apoptotic) peak that was down-regulated in the presence of the antioxidant N-acetyl-L-cysteine. Treatment with HPR resulted in a 30% reduction of cellular immunoreactivity to tyrosine kinase, whereas immunoreactivity to p185HER remained essentially unaltered. HPR exposure resulted in time-dependent increase in cellular metabolism of the retinoid as evidenced by increased formation of the inert metabolite N-(4-methoxyphenyl)-retinamide (MPR) and progressive increase in apoptosis. Thus, HPR-induced inhibition of aberrant proliferation may be caused, in part, by its ability to inhibit HER-2/neu-mediated proliferative signal transduction, retard cell cycle progression and upregulate cellular apoptosis.  (+info)

Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations. (3/2132)

High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing's sarcoma and medulloblastoma. However, the anti-tumour activity of busulfan as a single agent remains to be defined, and this was evaluated in athymic mice bearing advanced stage subcutaneous paediatric solid tumour xenografts. Because busulphan is highly insoluble in water, the use of several vehicles for enteral and parenteral administration was first investigated in terms of pharmacokinetics and toxicity. The highest bioavailability was obtained with busulphan in DMSO administered i.p. When busulphan was suspended in carboxymethylcellulose and given orally or i.p., the bioavailability was poor. Then, in the therapeutic experiments, busulphan in DMSO was administered i.p. on days 0 and 4. At the maximum tolerated total dose (50 mg kg(-1)), busulphan induced a significant tumour growth delay, ranging from 12 to 34 days in the three neuroblastomas evaluated and in one out of three medulloblastomas. At a dose level above the maximum tolerated dose, busulphan induced complete and partial tumour regressions. Busulphan was inactive in a peripheral primitive neuroectodermal tumour (PNET) xenograft. When busulphan pharmacokinetics in mice and humans were considered, the estimated systemic exposure at the therapeutically active dose in mice (113 microg h ml(-1)) was close to the mean total systemic exposure in children receiving high-dose busulphan (102.4 microg h ml(-1)). In conclusion, busulphan displayed a significant anti-tumour activity in neuroblastoma and medulloblastoma xenografts at plasma drug concentrations which can be achieved clinically in children receiving high-dose busulphan-containing regimens.  (+info)

Conjugated linoleic acid inhibits differentiation of pre- and post- confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells. (4/2132)

Conjugated linoleic acid (CLA; 18:2) is a group of isomers (mainly 9-cis, 11-trans and 10-trans, 12-cis) of linoleic acid. CLA is the product of rumen fermentation and can be found in the milk and muscle of ruminants. Animals fed CLA have a lower body fat content. The objective of this study was to establish the possible mechanisms by which CLA affects adipogenesis. 3T3-L1 is a well-established cell line that is used extensively in studying adipocyte biology. These cells typically grow in a culture medium until they reach confluence, at which time they are induced to differentiate by hormonal treatment (d 0). Treatment of 3T3-L1 cells with 25 to 100 micromol/L CLA inhibited differentiation in a dose-dependent manner, while linoleic acid treatment did not differ from DMSO-treated controls. Continuous treatment from d -2, -1, 0 or 2 to d 8 and treatment from d -2 to d 0 and from d 0 to d 2 inhibited differentiation. Differentiation was monitored morphologically (oil Red-O staining), enzymatically (reduction of activity of glycerol-3-phosphate dehydrogenase), and by northern analysis of peroxisome proliferator-activated receptor gamma2, CCAAT/enhancer binding protein alpha and adipocyte specific protein 2 mRNA. CLA inhibited cell proliferation of nonconfluent cells but did not affect cell division of confluent cells, as indicated by 5-bromo-2'-deoxyuridine incorporation and mitochondria metabolism. Therefore, CLA inhibited differentiation before confluence and during induction. However, cellular proliferation was only inhibited prior to induction. These results imply that fat reduction caused by CLA treatment may be attributed to its inhibition of both proliferation and differentiation of preadipocytes in animals.  (+info)

Flow cytometric cell cycle analysis of cultured porcine fetal fibroblast cells. (5/2132)

Normal development of nuclear transfer embryos is thought to be dependent on transferral of nuclei in G0 or G1 phases of the cell cycle. Therefore, we investigated the cell cycle characteristics of porcine fetal fibroblast cells cultured under a variety of cell cycle-arresting treatments. This was achieved by using flow cytometry to simultaneously measure cellular DNA and protein content, enabling the calculation of percentages of cells in G0, G1, S, and G2+M phases of the cell cycle. Cultures that were serum starved for 5 days contained higher (p < 0.05) percentages of G0+G1 (87.5 +/- 0. 7) and G0 cells alone (48.3 +/- 9.7) compared with rapidly cycling cultures (G0+G1: 74.1 +/- 3.0; G0: 2.8 +/- 1.2). Growth to confluency increased (p < 0.05) G0+G1 percentages (85.1 +/- 2.8) but did not increase G0 percentages (6.0 +/- 5.3) compared to those in cycling cultures. Separate assessment of small-, medium-, and large-sized cells showed that as the cell size decreased from large to small, percentages of cells in G0+G1 and G0 alone increased (p < 0.05). We found 95.2 +/- 0.3% and 72.2 +/- 12.0% of small serum-starved cells in G0+G1 and G0 alone, respectively. Cultures were also treated with cell cycle inhibitors. Treatment with dimethyl sulfoxide (1%) or colchicine (0.5 microM) increased percentages of cells in G0 (24.8 +/- 20.0) or G2+M (37.4 +/- 4.6), respectively. However, cells were only slightly responsive to mimosine treatment. A more complete understanding of the cell cycle of donor cells should lead to improvements in the efficiency of nuclear transfer procedures.  (+info)

In vitro cell cycle arrest, in vivo action on solid metastasizing tumors, and host toxicity of the antimetastatic drug NAMI-A and cisplatin. (6/2132)

The effects of NAMI-A (imidazolium trans-imidazoledimethyl sulfoxide-tetrachlororuthenate) are compared with cisplatin on tumor cells cultured in vitro at doses of 1 to 100 microM and on tumor metastases in vivo at maximum tolerated doses. Using mouse tumors that metastasize to the lungs, NAMI-A given i.p. for 6 consecutive days at 35 mg/kg/day, was effective independently of the tumor line being treated and of the stage of metastasis growth. Conversely, cisplatin (2 mg/kg/day for 6 days) was as effective as NAMI-A on MCa mammary carcinoma and TS/A adenocarcinoma and less effective than NAMI-A on Lewis lung carcinoma. Cisplatin reduced body weight gain and spleen weight during treatment and was much more toxic than NAMI-A on liver sinusoids, kidney tubules, and lung epithelium. In vitro NAMI-A caused a transient cell cycle arrest of tumor cells in the premitotic G2/M phase, whereas cisplatin caused a progressive dose-dependent disruption of cell cycle phases. Correspondingly, NAMI-A did not modify cell growth, whereas cisplatin caused a dose-dependent reduction of cell proliferation, as determined by sulforhodamine B test. Thus, NAMI-A, unlike cisplatin, is a potent agent for the treatment of solid tumor metastases as well as when these tumor lesions are in an advanced stage of growth. NAMI-A is endowed with a mechanism of action unrelated to direct tumor cell cytotoxicity, and such mechanism of action is responsible for a reduced host toxicity.  (+info)

Stable thiobarbituric acid chromophore with dimethyl sulphoxide. Application to sialic acid assay in analytical de-O-acetylation. (7/2132)

With dimethyl sulphoxide instead of butanol in the thiobarbituric acid assay for sialic acid, a non-fading chromophore with lambdamax. = 549 nm was produced in a homogeneous solution, allowing dilution of the test mixture in case of high colour yield. This test adapted well to studies on alkaline de-O-acetylation. Bovine and rat submaxillary mucins, and rabbit Tamm-Horsfall urinary sialoproteins contain O-acetyl isomers of neuramine acid that are resistant to the thiobarbituric acid assay. Alkaline de-O-acetylation converted resistant O-acetylneuraminic acid into thiobarbituric acid-reactive sialic acid, and such conversion paralleled de-O-acetylation as measured by the ferric hydroxamate method. The colour increment was similar when the alkaline treatment of bovine submaxillary mucin either preceded or followed the acid hydrolysis. Only alkaline preptreatment was effective with rat submaxillary mucin. By selecting optimal conditions for alkaline de-O-acetylation, O-acetyl isomers can be accurately assessed by the thiobarbituric acid assay.  (+info)

Regulation of IL-8RA (CXCR1) expression in polymorphonuclear leukocytes by hypoxia/reoxygenation. (8/2132)

Interleukin-8 (IL-8) is an important mediator of neutrophil (PMN) function and the type A IL-8 receptor (IL-8RA) mediates these pro-inflammatory signals. Hypoxia or hypoxia/reoxygenation (H/R) affects the production of IL-8, but no data is available regarding its effect on IL-8RA expression. The purpose of this study was to determine the effects of hypoxia and/or H/R on the expression of IL-8RA in PMN. We demonstrated that IL-8RA mRNA levels were similar under normoxic and hypoxic conditions but H/R resulted in a significant reduction in mRNA expression between 30 and 60 min. IL-8RA protein also decreased with reoxygenation of whole blood, which was altered by the addition of specific antioxidants. Therefore, H/R appears to attenuate the effect of IL-8 by down-regulating IL-8RA in PMN. These data show that changes in oxygen tension within the wound site not only affect the expression of inflammatory cytokines, but also control their actions by regulating their receptors.  (+info)

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Objective To explore the role of Nrf2/EZH2 in mediating erythroid differentiation in mouse erythroleukemia cells under DMSO exposure. Methods MEL cells were treated with DMSO. Erythroid differentiation was detected by bezidine staining. The expression levels of Nrf2 and EZH2 were determined by western blotting. Results DMSO induced erythroid differentiation in MEL cells,along with significant induction of Nrf2 and EZH2 expression. TBHQ,a selective Nrf2 activator,increased the protein level of Nrf2.Interestingly,TBHQ also induced EZH2 expression. The lentiviral particle containing Nrf2 short hairpin RNA( shRNA) efficiently blocked TBHQ-induced EZH2 levels. Moreover,Nrf2 or EZH2 shRNA significantly inhibited DMSO-induced erythroid differentiation. Conclusion Nrf2 induction is involved in MELerythroid differentiation under DMSO exposure by regulating EZH2.
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DMSO dimethyl sulfoxide Dimethyl sulfoxide (DMSO, dimethyl sulfoxide), (CH3) 2SO is an organic chemical compound that belongs to the group of sulfoxides. It is used as a chemical reagent and solvent. DMSO is most commonly used in the form of a liquid aqueous solution with a concentration of 70-90% - usually externally, or in gels of various concentrations. Species: clean Specification Name: Dimethylsulfoxide Synonyms: DMSO, dimethyl sulfoxide, dimethyl sulfoxide, methylsulfoxide, methylsulfinylmethane, Genre: Clean Cleanliness: Clean min. 99.9% Chemical formula: (CH3) 2SO. Learn More ...
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Polyadenylated and nonpolyadenylated mRNA were prepared from polysomes and from the postribosomal supernatant of noninduced and DMSO-induced Friend cells. The mRNA preparations were translated in a wheat germ cell-free system and the in vitro synthesized proteins, fractionated by polyacrylamide gel electrophoresis, were compared by fluorography. The electrophoretic analysis shows that four preparations of poly (A) + RNA code for many different peptides and that most of these peptides are present in each of the poly (A) + RNA translation products. However, the electrophoretic patterns of these translation products differ in the relative amounts of peptides comigrating in the gel electrophoresis. After DMSO treatment, Friend cells show significative differences in the polysomal and nonpolysomal mRNA pools. With induction, globin becomes the most abundant product of the polysomal poly (A) + RNA, while the relative amounts of peptides coded by nonglobin polysomal poly (A) + RNA are reduced. In ...
Dimethyl sulfoxide (DMSO) is frequently used as a solvent in biological studies and as a vehicle for drug therapy; but the side effects of DMSO, especially on the cell environment, are not well understood, and controls with DMSO are not neutral at higher concentrations. Herein, electrochemical measurement techniques are applied to show that DMSO increases exocytotic neurotransmitter release, while leaving vesicular contents unchanged. In addition, the kinetics of release from DMSO-treated cells are faster than that of untreated ones. The results suggest that DMSO has a significant influence on the chemistry of the cell membrane, leading to alteration of exocytosis. A speculative chemical mechanism of the effect on the fusion pore during exocytosis is presented.
Early membrane events in erythroid differentiation were investigated by means of cell electrophoresis utilizing cultured Friend erythroleukemia cell clones of different inducibility. The cell electrophoretic mobility decreased by 18% within 30 min of treatment with 1.5% dimethyl sulfoxide (DMSO) in highly inducible clones but not in noninducible clones. The reduced mobility persisted for 5 days of incubation with DMSO until hemoglobin synthesis. DMSO treatment for less than 16 hr and subsequent incubation without the drug resulted in the complete recovery of the mobility and no hemoglobin synthesis. Longer exposure to DMSO resulted in the loss of recovery of mobility and an increasing fraction of benzidine-positive cells seen on Day 5. Measurement of the electrophoretic mobility after the removal of acidic sugars by their specific enzymes suggested that hyaluronidase-sensitive negative charges were lost from the cell surface only in highly inducible clones. The mobility reduction associated with ...
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UTUShop » Kirjat ja julkaisut » Annales Universitatis Turkuensis » Towards enhancing the durability and strength of dentin-resin bond : the role of dimethyl sulfoxide (DMSO) as an alternative solvent in dental adhesives ...
Learn why Dimethyl sulfoxide is used for emergency treatment of brain and spinal cord inflammation, endotoxemia, laminitas, and in the treatment of very sick, young foals.
The function of dimethyl sulfoxide (DMSO) as both an electrophilic and nucleophilic reagent has been well established. However, its reactions with substrates which are similarly biphilic have attracted little comment, even though they are of potential mechanistic and preparative interest. Discussed are the mechanisms involved in the heating of alpha-chloro-p-nitrobenzaldoxime in DMSO. (Author)(*OXIMES
Mitogen-activated protein kinase (MAPK) isoform p42 is known to be active in exponentially growing cells at several points of the cell cycle. A high basal activity was present in three cell lines representative of immature myeloid cells tested: uHL-60, AML-14, and MPD. However, DMSO-induced differentiation of HL-60 cells (dHL-60) and subsequent expression of the neutrophilic phenotype occurred with a concomitant reduction on the basal level of MAPK activity. Simultaneously, extracellular stimuli like the cytokine granulocyte/macrophage colony-stimulating factor (GM-CSF) induced a fast (|10 min) and robust response. In terms of MAPK activity, the more mature the cell was, the higher the corresponding activity, in the three differentiation series considered: AML-14 | 3D10; MPD | G-MPD; uHL-60 | dHL-60 | neutrophils. Interestingly, peripheral blood neutrophils expressed the highest (16-fold) MAPK activation level in response to GM-CSF. Finally, using the specific MAPK inhibitor PD-98059, we demonstrated
Cell growth inhibition assay and data analysis Cells were plated at appropriate density in 96 very well plates such they would remain in log growth with the finish of assay time. The cells had been allowed to attach overnight before getting exposed to Mek inhibitor CI 1040, UO126 or GSK1120212 for 72 h. Medication have been dissolved in dimethyl sulfoxide as 10 mM stock, and a set of 9 doses in 1,5 serial dilution was added in tripli cate wells. The last DMSO concentration from the taken care of well was 0. 3% or much less. The cell development was established utilizing Cell Titer Glo assay, with slight modification from the producers protocol at day 0 and day 3 of drug publicity. Briefly, Cell Titer Glo reagent was diluted with phosphate buffered saline as well as culture media was eliminated in the 96 well plate prior to including 50 ?l per well from the diluted Cell Titer Glo rea gent.. Luminescence in the assay was recorded making use of BIO TEK FLx800. Data calculations were manufactured in ...
Dimethyl sulfoxide is used to enhance dermal absorption of many chemicals.A solvent for many organic and inorganic compounds including fats, carbohydrates, dyes, resins, and polymers.Used in antifreeze or hydraulic fluids and as a cryopreservative for cell cultures.Used in the oxidation of thiols and disulfides to sulfonic acids. Used as a PCR cosolvent to help improve yields, especially in long PCR. ...
Looking for SPECTRUM Dimethyl Sulfoxide,100mL,CAS 67-68-5 (46AJ70)? Graingers got your back. Price:$154.50. Easy ordering & convenient delivery. Log-in or register for your pricing.
Wiens, A W.; Clintock, P R.; and Papaconstantinou, J, "The dependence of erythroid differentiation on cell replication in dimethyl sulfoxide-treated friend leukemia- -virus-infected cells." (1976). Subject Strain Bibliography 1976. 2169 ...
MSM (Methylsulfonylmethane) 750 mg - 60 tabletsRecommended Use:2 to 4 tablets daily, or as recommended by your health care professional.MSM serves as an important source of bioavailable dietary sulfur, a mineral which plays a critical role in maintaining the integrity and elasticity of connective and other tissues. It is an important component in proteins found throughout the body such as in hair, nails, skin and tendons. Vitamin C helps support connective tissue, amino acid metabolism, hormone synthesis and is a key factor in the bodys natural defenses. MSM is a naturally occurring form of organic sulfur found mainly in protein-rich foods such as eggs, fish and lean meat. Taking MSM throughout the day helps to replenish the bodys supply of assimilable sulfur.Ingredients:WARNING: Keep out of the reach of children. Do not use if either tamper-evident seal is broken or missing. Store in a cool, dry place. Not for use by pregnant or nursing women.
St. Francis MSM (Methylsulfonylmethane) is a natural anti-inflammatory sulfur compound thats great for arthritis, as well as being an immune system modulator.
Ask questions and get answers about Chondroitin/Glucosamine/Methylsulfonylmethane. Our support group helps people share their own experience. 10 news articles.
The supplement methylsulfonylmethane, sometimes called MSM, is a sulfur compound promoted as useful for health conditions involving pain and inflammation.
Use:. This mmp substrate can be used to assess activity of MMP9 and MMP2. This mmp substrate has been used in enzymatic and cell based assays to assess activity of MMP9 and MMP2 since it is specific for this family of metalloproteinases. See our Product Sheets for its substrate specificity profile. Typically, the peptide is dissolved in DMSO to make a stock solution of about 10uM concentration. When used for in vitro assays, the substrate is often used at about 10mM concentration. Remember to keep the DMSO concentration in the final reaction at 1% or below, to avoid DMSO effects on the reaction, and remember to have an equivalent percentage of DMSO in the background wells. For use with the MMPs, the buffer should contain 50 mM Tris, pH 7.5, 150 mM NaCl, 2 mM CaCl2, 5 µM ZnSO4, and 0.01% Brij-35. Excitation and emission wavelengths are 485 and 530 nm respectively.. Molecular Weight:. 1423.4 g/mol. Purity:. Greater than 95% as assessed by HPLC and Mass Spectrometry.. Solubility:. 1 mg/ml in water ...
Use:. This mmp substrate can be used to assess activity of enzymes in the MMP family. The peptide sequence was described originally as a biosensor for MT1-MMP or MMP14 in "Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. Ouyang M, et al. Cancer Res. 2010 Mar 15;70(6):2204-12. doi: 10.1158/0008-5472.CAN-09-3698″. It demonstrates reasonably strong activity against MT1-MMP or MMP14 and MMP3, but has the highest activity against MMP9 with specificity constants, kcat/Km (M-1s-1), ranging from approximately 103 to 106. See also our Product Sheets for its substrate specificity profile. This substrate is not processed by ADAM family members. Typically, the peptide is dissolved in DMSO to make a stock solution of about 10mM concentration. When used for in vitro assays, the substrate is often used at about 10uM concentration. Remember to keep the DMSO concentration in the final reaction at 1% or below, to avoid DMSO effects on the ...
My first day using DMSO was a complete success. DMSO stings like sunburn at 100% dilution. It also turns the skin red just like sunburn. But that only lasts about 20 minutes. It gets itchy, prickly & stings. Then the stuff soaks into the skin - you dont rub it.. After 10 minutes the analgesic property is pretty much 100%. I could feel zero pain in my shoulder that has hurt for 11 weeks. I could even stretch in positions that would have dropped me to the floor in agony an hour earlier.. This analgesia lasts for 3-5 hours and is very pronounced. Yesterday I had the best workout I have had in 11 weeks - it was great.. You do need to be careful because there is such great pain reduction you dont want to forget you have an injury. The smell is there but not sickening to the user. I dont know how it would smell to another person. Probably quite bad.. As for the anti inflammatory effect it will take a couple of weeks to kick in I expect.. With DMSO you must be very careful not to contaminate it with ...
Results: The TLR7 agonist compound A (a close analog of GS-9620), had no direct antiviral activity in HBV-infected PHH, consistent with the lack of functional TLR7 in hepatocytes. In contrast, sustained exposure of HBV-infected PHH to TLR7-CM strongly reduced the levels of HBV DNA and HBeAg (>90%), as well as HBsAg and HBV RNA (>75%), without detectable toxicity. Reductions in viral parameters were observed when PHH were treated with TLR7-CM early (3 days) or late (13 days) post-infection, but were not induced by media from control DMSO-treated PBMCs. We next compared the durability of short (3 day) and long (10 day) treatment of HBV-infected PHH with TLR7-CM. Short duration treatment (days 3-6 post-infection) only transiently reduced HBeAg. In contrast, prolonged treatment (days 3-13 post-infection) induced more sustained suppression of HBeAg, with rebound still incomplete 7 days after removal of TLR7-CM (day 20). A survey of cytokines in TLR7-CM identified recombinant IFN-α2a as a potent ...
BioAssay record AID 780551 submitted by ChEMBL: Neuroprotective activity against Sprague-Dawley rat embryo cortex NSC assessed as reduction of mRNA ratio of bcl2 to bax at 10 uM after 2 days by RT-PCR method relative to DMSO-treated control.
SAHA was bought as being a dry powder and reconstituted in dimethyl sulfoxide at 0. five M and stored at 20C. Proliferation assay Each cell lines have been plated at minimal seed onto a 24 properly plate. This was allowed overnight incubation. The fol lowing day, the media was eliminated and replaced with media containing preset concentrations of valproate or SAHA. These Inhibitors,Modulators,Libraries have been incubated for 72 hrs. At that point, the media was removed and media containing no remedy but supplemented with 10% Alamar blue was extra. This was allowed to incubate for three hours at which stage absorbance was go through at 570 and 600 nm. Each problem had four replicates. The ratio of absorb ance at 570 to 600 nm was scaled from zero for that no cell wells to 100% to the no therapy wells. The data have been analyzed by t test making use of JMP Statistical Application.. Expression evaluation Cells were grown in 25 cm2 T flasks and treated with valproate from 0 mM to 5 mM while SAHA ...
dimethyl sulfone: MSM is abreviation; a normal oxidative metabolite product of dimethyl sulfoxide (DMSO) found in foods; RN given refers to unlabeled cpd;
DMSO definition, dimethyl sulfoxide: a liquid substance, C 2 H 6 OS, used in industry as a solvent and paint and varnish remover; proposed as an analgesic and anti-inflammatory in musculoskeletal disorders. See more.
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MSM (Methylsulfonylmethane) is a metabolite of DMSO (dimethyl sulfoxide) found in nature. Found extensively in nature, DMSO has been used as a carrier for various compounds. The strong odor, along with the resultant foul breath and skin irritations that r
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DMSO tends to build up white blood cells and increase immune production of MIF (migration inhibitory factors) of macrophages. Thus, the immune system is made more effective by allowing macrophages to move more quickly. Thus DMSO modulates lymphocytes, and it therefore reactivates the production of MIF. It also diminishes allergic reactions by unfolding the cell membrane and making more cell receptor sites available to attachment by specific antigens.. The modulating effect of DMSO on lymphocytes also tends to increase the production of lymphokines (chemical immune cell mediators) such as interferon. It potentiates cell mediated immunity and can be effective in multiple sclerosis, systemic lupus, erythematosus, rheumatoid arthritis, thyroiditis, ulcerative colitis, cancer, etc.. This is not a drug in the usual sense, since a drug treats disease symptoms. DMSO treats altered cellular function or damaged cells. The cells become healed and restored by changing and stabilizing the "water structure" ...
The graph above shows the effect of 3% DMSO on YBR033W. From the data represented the average doubling rate for the YBR033W knockout strain without DMSO was 634 minutes. When DMSO is added the average doubling time increased to 1292 minutes. This shows that 3% DMSO did add stress to this knockout strain. The average doubling time of WT:BY4735 without DMSO was 514 minutes. The average doubling rate for WT:BY4735 with DMSO was 1529 minutes. If we compare the average doubling rate of WT:BY4735 with DMSO to YBR033W with DMSO we can see that without the YBR033W gene the yeast was able to grow more quickly under DMSO induced stress. ...
Dimethyl sulfoxide (DMSO) is a clear water soluble liquid that can dissolve both polar and nonpolar compounds. Chemicals that are insoluble in water may require DMSO as an ideal solvent for cell permeable drugs. The disadvantage is that DMSO can affect cells, and so there must always be a parallel control setting where cells undergo treatment with everything but the chemical; also known as a vehicle control. The treatment group of cells will then be known with confidence to be chemical-dependent relative to the vehicle-dependent negative control. DMSO for cell culture should ideally be ,0.1% (avoid use greater than 1% DMSO), since DMSO is cytotoxic at higher concentrations. However this is not always realistic depending on the chemical inhibitor. Determining a vehicle (DMSO) dose/response curve (viability) can determine the best approach. Hydrophobic/polar compounds may only dissolve in DMSO, so up to 5% DMSO in the culture assay may be necessary, in which case the vehicle control is ...
Dimethyl sulfoxide (DMSO) is a clear water soluble liquid that can dissolve both polar and nonpolar compounds. Chemicals that are insoluble in water may require DMSO as an ideal solvent for cell permeable drugs. The disadvantage is that DMSO can affect cells, and so there must always be a parallel control setting where cells undergo treatment with everything but the chemical; also known as a vehicle control. The treatment group of cells will then be known with confidence to be chemical-dependent relative to the vehicle-dependent negative control. DMSO for cell culture should ideally be ,0.1% (avoid use greater than 1% DMSO), since DMSO is cytotoxic at higher concentrations. However this is not always realistic depending on the chemical inhibitor. Determining a vehicle (DMSO) dose/response curve (viability) can determine the best approach. Hydrophobic/polar compounds may only dissolve in DMSO, so up to 5% DMSO in the culture assay may be necessary, in which case the vehicle control is ...
C) Four GCBDLBCL cells lines [1 wild-type (wt), 3 mutated (mut) EZH2] were treated with 500 nmol/l BAY 1238097 or with an EZH2 inhibitor (DZNep and GSK126, both used at the concentration of 500 nmol/l) as single agents and in combination for 72 h. The arrow indicates the EZH2 correct band. Dimethyl sulphoxide (DMSO) alone was added as negative control cells. Membranes were hybridized with antibodies against EZH2, H3K27me3, histone H3 and GAPDH.. ...
Import Data And Price Of Dimethyl Amino , www.eximpulse.com Eximpulse Services will provide you the latest and relevant market intelligence reports of Dimethyl Amino Import Data. You can find live data of maximum number of ports of India which is based on updated shipment data of Indian Customs. Only previous two days data will be seen on website. You can use this Dimethyl Amino import data for multiple kinds of analysis; lets say Import price, Quantity, market scenarios, Price trends, Duty optimization and many more. You can go through some of the sample shipment records for Dimethyl Amino import data mentioned above. Here on Eximpulse Services you will get all kind of free sample as well as detailed reports of Export/ Import data as per your requirement. To get in touch for any kind of enquiry related to free sample or detailed report contact on +91-120-408-4957, +91-120-408-4958,+91-120-428-4019.. Data post 2012 as per Notification No.18/2012 - Customs(N.T.) and does not have names of Indian ...
DMSO (Dimethyl Sulfoxide) Roll-On is to be used as a solvent only. DMSO is a colorless liquid derived from lignin, the natural material that bonds together the cells of trees. It is extracted during the manufacturing of pulp and then processed. It is an organic non-synthesized product. 3 oz roll-on. ...
You are viewing an interactive 3D depiction of the molecule 1-[(5r,6r,8r,9r)-4-amino-9-{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-6-({[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-5-methyl-2,4(1h,3h)-pyrimidinedione (C24H43N3O8SSi2++) from the PQR.
Dimethyl chlorophosphate 813-77-4 MSDS report, Dimethyl chlorophosphate MSDS safety technical specifications search, Dimethyl chlorophosphate safety information specifications ect.
Buy MSM 1500 mg 120 Caplets & other MSM Products supplements. Methylsulfonylmethane (MSM) is a natural source of sulfur, a major building block of glycosaminoglycans which plays a role in the maintenance of joint cartilage.
The Facts about MSM Supplements Methylsulfonylmethane (or MSM) is a popular yet controversial nutritional supplement. Its proponents claim that it benefit...
90 Capsules. MSM 500mg is composed of Methylsulfonylmethane (MSM) which is an organic sulphur-compound that occurs naturally in a variety of fruits, vegetables, grains, and animals including humans. MSM is believed to be non-toxic and shows no side effects even at high dosages. Sulfur supports healthy muscles, tendons, and ligaments, and it helps maintain the integrity of articular cartilage ...
90 Capsules. MSM 500mg is composed of Methylsulfonylmethane (MSM) which is an organic sulphur-compound that occurs naturally in a variety of fruits, vegetables, grains, and animals including humans. MSM is believed to be non-toxic and shows no side effects even at high dosages. Sulfur supports healthy muscles, tendons, and ligaments, and it helps maintain the integrity of articular cartilage ...
Each Power Pack contains: 1500 mg glucosamine HCl 800 mg chondroitin sulfate 1500 mg MSM (Methylsulfonylmethane) Get a free sample of Cosamin MSM
MSM, methylsulfonylmethane, is a natural sulfur that does wonders for the body and I want to share this information with as many people as I can to help others like myself. I couldnt begin to imagine what my life would be like, or the pain I would...
Dimethyl formamide. 6.7. -. -. -. -. Dimethyl sulfoxide. 20. -. -. -. -. Vapor pressure. Temperature. (°C). Pressure. (kPa). ... Terephthalic acid and its dimethyl ester have very low toxicity, with LD50s over 1 g/kg (oral, mouse).[2] ... In the 1960s, all the terephthalic acid produced was converted to its dimethyl ester, since TPA was infusible and difficult to ... The fibers were made from dimethyl terephthalate by transesterification with ethylene glycol. Terephthalic acid was produced by ...
"Acidity of Strong Acids in Water and Dimethyl Sulfoxide". The Journal of Physical Chemistry A. 120 (20): 3663-3669. doi:10.1021 ... "Acidity of Strong Acids in Water and Dimethyl Sulfoxide". The Journal of Physical Chemistry A. 120 (20): 3663-3669. doi:10.1021 ...
... where dimethyl sulfoxide is called "Dimethylschwefeloxyd". *^ Kathrin-Maria Roy "Sulfones and Sulfoxides" in Ullmann's ... "Dimethyl sulfoxide (DMSO) waste residues and municipal waste water odor by dimethyl sulfide (DMS): the North-East WPCP plant of ... Establishment of an absolute scale of acidities in dimethyl sulfoxide solution". J. Am. Chem. Soc. 97 (24): 7006-7014. doi: ... Epstein WW, Sweat FW (March 1967). "Dimethyl Sulfoxide Oxidations". Chemical Reviews. 67 (3): 247-260. doi:10.1021/cr60247a001. ...
Dimethyl sulfoxide (DMSO). CH3-S(=O)-CH3. 189 °C. 47. 1.092 g/ml. ...
Dimethyl sulfoxide (DMSO) is also regarded as a conventional cryoprotectant. Glycerol and DMSO have been used for decades by ... dimethyl sulfoxide), propylene glycol, and a colloid was for many years the most effective of all artificially created ...
... intravenous dimethyl sulfoxide; administration of products such as Biosponge or activated charcoal via nasogastric tube to bind ...
Sulfoxide Sulfinyl RSOR' -sulfinyl-. (-SOR') di(substituent) sulfoxide (Methanesulfinyl)methane (prefix) or. Dimethyl sulfoxide ... Dimethyl sulfide (suffix) Disulfide. Disulfide RSSR' substituent disulfanyl-. (-SSR') di(substituent) disulfide ( ...
The oxidation of primary halide with dimethyl sulfoxide to form an aldehyde. ...
Some pKa values at 25 °C for acetonitrile (ACN)[33][34][35] and dimethyl sulfoxide (DMSO)[36] are shown in the following tables ... pKa values of organic compounds are often obtained using the aprotic solvents dimethyl sulfoxide (DMSO)[31] and acetonitrile ( ... The Brønsted-Lowry definition applies to other solvents, such as dimethyl sulfoxide: the solvent S acts as a base, accepting a ...
"Equilibrium acidities in dimethyl sulfoxide solution". Accounts of Chemical Research. 21 (12): 456-463. doi:10.1021/ar00156a004 ...
1892-1894 doi:10.1107/S0108270184009963 F. G. Bordwell (1988). "Equilibrium acidities in dimethyl sulfoxide solution". Acc. ...
Dennis P. Bauer; Roger S. Macomber (1975). "Iodide catalysis of oxidations with dimethyl sulfoxide. Convenient two-step ...
It is soluble in dimethyl sulfoxide (DMSO). PMA is water-sensitive and unlike PMMA, is not stable against alkalies. It is used ...
This type of reaction together with dimethyl sulfoxide as a solvent is a convenient method for the synthesis of nitriles. The ... An Advantageous Nucleophilic Displacement in Dimethyl Sulfoxide". Journal of Organic Chemistry. 25 (6): 877-879. doi:10.1021/ ...
... which will oxidize the dimethyl sulfide back to dimethyl sulfoxide or to dimethyl sulfone, both of which are odourless and ... Dess-Martin oxidation Omura, K.; Swern, D. (1978). "Oxidation of alcohols by "activated" dimethyl sulfoxide. A preparative, ... Tidwell, T. T. (1990). "Oxidation of alcohols by activated dimethyl sulfoxide and related reactions: An update". Synthesis ( ... ISBN 0-387-23607-4. Mancuso, A. J.; Swern, D. (1981). "Activated dimethyl sulfoxide: Useful reagents for synthesis". Synthesis ...
MSM and the corresponding sulfoxide, dimethyl sulfoxide ((CH3)2SO, or DMSO), have different physical properties. MSM is a white ... Morton, JI; Siegel, BV (1986). "Effects of oral dimethyl sulfoxide and dimethyl sulfone on murine autoimmune ... The spectrum of biological effects of dimethyl sulfoxide (DMSO) and MSM differ, but those of DMSO may be mediated, at least in ... Kocsis, JJ; Harkaway, S; Snyder, R (1975). "Biological effects of the metabolites of dimethyl sulfoxide". Annals of the New ...
... and dialkali salts of dimethyl sulfone, dimethyl sulfoxide, and related compounds". J. Organomet. Chem. 59: 53-64. doi:10.1016/ ... "The Dimethyl Sulfoxide (DMSO) Anion - Dimsyl Ion" (PDF). Gaylord Chemical Corporation. October 2007. "Preparation of dimsyl ... is the sodium salt of the conjugate base of dimethyl sulfoxide. This unusual salt has some uses in organic chemistry as a base ... "One-pot synthesis of β-keto sulfones and β-keto sulfoxides from carboxylic acids". J. Org. Chem. 54 (23): 5620-5623. doi: ...
Dimethyl sulfoxide/acetic anhydride serves as oxidizing agent. The reaction does not proceed further to the carboxylic acid. ... The following figure shows the reaction mechanism: First, dimethyl sulfoxide (1) reacts with acetic anhydride to form a ... 33-36, ISBN 978-0-470-28662-3 J. Donald Albright, Leon Goldman (1967), "Dimethyl sulfoxide-acid anhydride mixtures for the ... The latter reacts upon elimination of acetic acid and dimethyl sulphide to the aldehyde. The Albright-Goldman oxidation is a ...
Colchicine and dimethyl sulfoxide are most commonly used. Dogs taking colchicine must be monitored closely for signs of bone ...
"Disulfide bond formation in peptides by dimethyl sulfoxide. Scope and applications". J. Am. Chem. Soc. 113 (17): 6657-6662. doi ... was formed after the removal of the But groups by methyltrichlorosilane with diphenyl sulfoxide in TFA. Importantly, formation ... "Total synthesis of human insulin by regioselective disulfide formation using the silyl chloride-sulfoxide method". Journal of ...
Dimethyl Sulfide, and Dimethyl Sulfoxide". Journal of the American Chemical Society. 99 (21): 6983-6986. doi:10.1021/ ...
Factors influencing selenium and white muscle disease: forage types, salts, amino acids and dimethyl sulfoxide. Nutr. Rep. Int ...
Guest molecules include dimethyl sulfoxide (DMSO), hydrazine, and urea. For example, N2H4 (hydrazine) can be intercalated into ... the material must be pre-intercalated with something like dimethylsulfoxide. However, when etching is conducted with ...
2009, 74, 2679). Equilibrium acidities in dimethyl sulfoxide solution Frederick G. Bordwell Acc. Chem. Res.; 1988; 21(12) pp ... "Acidity of Strong Acids in Water and Dimethyl Sulfoxide". The Journal of Physical Chemistry A. 120 (20): 3663-3669. Bibcode: ...
It is soluble in dimethyl sulfoxide and 100% ethanol. Capsaicin Nordihydrocapsaicin Homodihydrocapsaicin Homocapsaicin ...
ద్రావణీయత in dimethyl sulfoxide 18 g/100 g (25 °C)[1] బాష్ప పీడనం 0.01 kPa (471 °C). 0.1 kPa (541 °C)[2] ...
Dimethyl sulfur oxide; Herpid; Kemsol; Sclerosol; Sulfoxide, dimethyl; Methane, 1,1-sulfinylbis-; DMSO (methyl sulfoxide); ... Jakli, G.; van Hook, W.A., The Vapor Pressures of Dimethyl Sulfoxide and Hexadeuterodimethyl Sulfoxide from about 313 to 453 K ... Clever, H.L.; Westrum, E.F., Dimethyl sulfoxide and dimethyl sulfone. Heat capacities, enthalpies of fusion, and thermodynamic ... Jakli, Gyorgy; Alexander Van Hook, W., The vapor pressures of dimethyl sulfoxide and hexadeuterodimethyl sulfoxide from about ...
This chapter provides the diffusion coefficient of dimethyl-sulfoxide-d6 in water at different concentrations measured using ... Winkelmann J. (2018) Diffusion coefficient of dimethyl-sulfoxide-d6 in water. In: Lechner M.D. (eds) Diffusion in Gases, ... This chapter provides the diffusion coefficient of dimethyl-sulfoxide-d6 in water at different concentrations measured using ...
Dimethyl Sulfoxide Irrigation, USP; Kemsol; Rimso-50. What is this drug used for?. *It is used to ease pain, swelling, and ... Dimethyl Sulfoxide - Generated on July 20, 2019. ©2019 Memorial Sloan Kettering Cancer Center. ... If you have an allergy to dimethyl sulfoxide or any other part of this drug. ...
Trametinib Dimethyl Sulfoxide reference guide for safe and effective use from the American Society of Health-System Pharmacists ... Trametinib Dimethyl Sulfoxide. Class: Antineoplastic Agents. Chemical Name: N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino ... Trametinib Dimethyl Sulfoxide Dosage and Administration. General. * Confirm presence of BRAF V600E or V600K mutation prior to ... Uses for Trametinib Dimethyl Sulfoxide. Melanoma. Alone or in combination with dabrafenib for treatment of unresectable or ...
Looking for SPECTRUM Dimethyl Sulfoxide, Reagent, 1L (39H241)? Graingers got your back. Price $197.40. Easy online ordering ... Dimethyl Sulfoxide, Reagent is an organosulfur, colorless liquid and is also known as DMSO. It acts as an important polar ...
Dimethyl sulfoxide for your research needs. Find product specific information including CAS, MSDS, protocols and references. ... DMSO - Dimethyl sulfoxide, Dimethyl Sulfoxide (DMSO), Enzymes, Inhibitors, and Substrates, Life Science Reagents for RNAi, ... Dimethyl Sulfoxide Molecular Biology Reagent Dimethyl sulfoxide (DMSO) is a highly polar organic reagent that has exceptional ... Is Dimethyl sulfoxide a sterile product? No, this product is not considered sterile. Product Nos. D2560 and D2438 are sterile- ...
Dimethyl sulfoxide is produced industrially from dimethyl sulfide, a by-product of the Kraft process, by oxidation with oxygen ... "Dimethyl sulfoxide (DMSO) waste residues and municipal waste water odor by dimethyl sulfide (DMS): the North-East WPCP plant of ... where dimethyl sulfoxide is called "Dimethylschwefeloxyd". Kathrin-Maria Roy "Sulfones and Sulfoxides" in Ullmanns ... Dimethyl sulfoxide (DMSO) is an organosulfur compound with the formula (CH3)2SO. This colorless liquid is an important polar ...
Dimethyl sulfoxide) Liquid Solution at 1800PetMeds & reduce your pets joint inflammation. Get free shipping on orders over $49 ... DMSO (Dimethyl sulfoxide) Liquid Solution for Pets - 1800PetMeds. 1-800-738-6337 ... DMSO, also known as dimethyl sulfoxide is commonly used in equines and some dogs to reduce inflammation and swelling in the ... DMSO, also known as dimethyl sulfoxide is commonly used in equines and some dogs to reduce inflammation and swelling in the ...
Dimethylsulfoxide). Includes effectiveness, safety concerns such as side effects, and how Dmso (Dimethylsulfoxide) works. ... Dimethyl Sulfoxide, Dimethyl Sulphoxide, Dimethylsulfoxide, Diméthylsulfoxyde, Dimetilsulfóxido, Methyl Sulphoxide, NSC-763, SQ ... What is Dmso (dimethylsulfoxide)?. DMSO is a prescription medicine and dietary supplement. It can be taken by mouth, applied to ... How does Dmso (dimethylsulfoxide) work?. DMSO helps medicines get through the skin and can affect proteins, carbohydrates, fats ...
... Abbasi, Alireza Skripkin, Mikhail Yu. Stockholm ... The two dimethyl sulfoxide solvated rhodium(III) compounds, [Rh(dmso-kappa O)(5)(dmso-kappa S)](CF(3)SO(3))(3) (1 & 1* at 298 K ... The results show that the metal ion-oxygen bonding of dimethyl sulfoxide ligands is electrostatically dominated in those ...
Hydro-chloro-thia-zide forms a 1:1 solvate with dimethyl sulfoxide, C7H8ClN3O4S2·C2H6OS. The crystal structure contains a ... The dimethyl sulfoxide (DMSO) solvate, (I). , was produced during an automated parallel crystallization polymorph search on HCT ... A single-crystal sample of the title compound was recrystallized by slow evaporation of a dimethyl sulfoxide solution at 278 K. ...
monograph 3249 "Dimethyl Sulfoxide (DMSO) -- Technical". Atofina Chemicals, inc. Retrieved 26 May 2007. "Pure Component ... This page provides supplementary chemical data on dimethyl sulfoxide. The handling of this chemical may incur notable safety ...
Looking for SPECTRUM Dimethyl Sulfoxide,100mL,CAS 67-68-5 (46AJ70)? Graingers got your back. Price:$154.50. Easy ordering & ... Dimethyl Sulfoxide, anhydrous, is used when performing certain reactions where the presence of water can prevent a chemical ...
... in the electrochemical impedance spectra to the progression and mechanism of skin damage arising from exposure to dimethyl ... sulfoxide (DMSO). METHODS: Electrochemical impedance spectra measured before and after human cadaver skin was treated with neat ... Characterization of damaged skin by impedance spectroscopy: chemical damage by dimethyl sulfoxide.. ... electrochemical impedance spectra to the progression and mechanism of skin damage arising from exposure to dimethyl sulfoxide ( ...
Dimethyl sulfoxide ≥99.5% (GC), suitable for plant cell culture; CAS Number: 67-68-5; EC Number: 200-664-3; Synonym: DMSO; ... Dimethyl Sulfoxide - High Purity Solvents DMSO (Dimethyl Sulfoxide) is an organosulfur compound with the formula (CH₃)₂SO. It ... Dimethyl sulfoxide (DMSO) should be a liquid. Why did it arrive as a solid? ... Is Dimethyl sulfoxide a sterile product? No, this product is not considered sterile.Product Nos. D2560 and D2438 are sterile- ...
... dimethyl sulfoxide explanation free. What is dimethyl sulfoxide? Meaning of dimethyl sulfoxide medical term. What does dimethyl ... Looking for online definition of dimethyl sulfoxide in the Medical Dictionary? ... Related to dimethyl sulfoxide: Dimethyl sulfate, Dimethyl sulfide. DMSO. dimethyl sulfoxide, an industrial solvent that has the ... Synonym(s): dimethyl sulphoxide. dimethyl sulfoxide. Dimethyl sulfoxide, DMSO. A colorless liquid of exceptional solvent ...
Methyl Sulfoxide
Shelf Life (months): 36
Storage: RedChemicals for science education are available in easy-to-use ... Dimethyl Sulfoxide CAS Number: 67-68-5. Formula Weight: 78.13. Formula: C2H6SO. Density (g/mL): 1.10. Boiling Point (°C): 189. ... Synonyms: DMSO, Methyl Sulfoxide. Shelf Life (months): 36. Storage: Red. Note: The chemical specifications for some items on ...
Catalyzes the reduction of dimethyl sulfoxide (DMSO) and trimethylamine N-oxide (TMAO) to dimethyl sulfide (DMS) and ... The terminal DMSO reductase can also use various sulfoxides and N-oxide compounds as terminal electron acceptor in addition to ...
dimethyl sulfoxide, dmso, methyl sulfoxide, dimethylsulfoxide, dimethyl sulphoxide, methane, sulfinylbis, demsodrox, demasorb, ... dimethyl sulfoxide, dmso, methyl sulfoxide, dimethylsulfoxide, dimethyl sulphoxide, methane, sulfinylbis, demsodrox, demasorb, ... Dimethyl Sulfoxide, PHOTREX™ Reagent, J.T.Baker™ 4L; Narrow Mouth Amber Glass Bottle ...
Dimethyl sulfoxide (DMSO) added to agar overlays during plaque assays of simian virus 40 (SV40) in CV1 monkey cells increases ... Dimethyl Sulfoxide*. Haplorhini. Kidney. Plaque Assay / methods*. Radiation Effects. Simian virus 40 / growth & development*, ... Dimethyl sulfoxide (DMSO) added to agar overlays during plaque assays of simian virus 40 (SV40) in CV1 monkey cells increases ...
Terminal reductase during anaerobic growth on various sulfoxides and N-oxide compounds. Allows E.coli to grow anaerobically on ... to dimethyl sulfide (DMS). DMSO reductase serves as the terminal reductase under anaerobic conditions, with DMSO being the ... Catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). DMSO reductase serves as the terminal reductase ... dimethyl sulfoxide reductase complex Source: EcoCyc ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for ...
... dimethyl sulphoxide) on electron transport in chloroplast membranes has been studied. It has been found that concentrations of ... Dimethyl Sulfoxide / pharmacology*. Dose-Response Relationship, Drug. Electron Transport / drug effects. Hydrogen / metabolism ... The effect of DMSO (dimethyl sulphoxide) on electron transport in chloroplast membranes has been studied. It has been found ...
This action of dimethyl sulfoxide, which was reversible, may represent the derepression of leukemic cells to permit their ... Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide. Charlotte Friend, William Scher, J. G. Holland, and Toru Sato ... line of murine virus-induced erythroleukemia were stimulated to differentiate along the erythroid pathway by dimethyl sulfoxide ... Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl ...
Dimethylsulfoxide (DMSO) has been in clinical use since the early 1960s. In 1967 the discovery that DMSO can greatly reduce ... Erk Y, Raskin DJ, Mace M Jr: In: de La Torre JC (ed). Dimethyl sulfoxide alteration of collagen. NY Acad Sci411:364-368, 1983 ... Gries F, Bublitz G, Lindner J: The effect of dimethyl sulfoxide on the components of connective tissue. Ann NY Acad Sci141:630- ... Rubin LF, Barnett KC: Ocular effects of oral and dermal applications of dimethyl sulfoxide in animals. Ann NY Acad Sci141:345, ...
Dimethyl sulfoxide is used to enhance dermal absorption of many chemicals.A solvent for many organic and inorganic compounds ... Dimethyl sulfoxide is a dipolar, aprotic solvent. Has been shown to accelerate strand renaturation (1-10% concentration) and is ...
  • DMSO (dimethyl sulfoxide) is a highly polar, aprotic organic solvent with many applications in organic chemistry and molecular biology. (sigmaaldrich.com)
  • Dimethyl sulfoxide (DMSO) is a highly polar organic reagent that has exceptional solvent properties for organic and inorganic chemicals. (sigmaaldrich.com)
  • dimethyl sulfoxide , an industrial solvent that has the ability to penetrate plant and animal tissues and to preserve living cells during freezing. (thefreedictionary.com)
  • Dimethyl sulfoxide is used to enhance dermal absorption of many chemicals.A solvent for many organic and inorganic compounds including fats, carbohydrates, dyes, resins, and polymers.Used in antifreeze or hydraulic fluids and as a cryopreservative for cell cultures.Used in the oxidation of thiols and disulfides to sulfonic acids. (mpbio.com)
  • Dimethyl sulfoxide is a dipolar, aprotic solvent. (mpbio.com)
  • Dimethyl sulfoxide (DMSO) is an extraordinary solvent that, in the last 30 has been used in a wide variety of medical applications. (encognitive.com)
  • dimethyl sulfoxide is widely used as solvents and reagents, particularly as the processing reagent and spinning solvent at the reaction of acrylonitrile polymerization used for polyurethane synthesis and the spinning solvent. (chemicalbook.com)
  • Dimethyl sulfoxide (DMSO) can be widely used as solvent and reaction reagent, especially as processing solvent and laddering solvent in the acrylonitrile polymerization reaction, and synthetic solvent and laddering solvent for polyurethane, also for polyamide, polyimide, polysulfone resin, aromatic hydrocarbon, butadiene and Chlorofluoroaniline etc. (ecvv.com)
  • According to the European Pharmacopoeia and the United States Pharmacopeia dimethyl sulfoxide (DMSO) is a class 3 solvent and it is used in the pharmaceutical industry amongst others as an additive for the lyophilisation process. (rsc.org)
  • This paper deals with the use of tetrabutylammonium fluoride/dimethylsulfoxide (TBAF/DMSO) to characterize the molar mass distribution of non-derivatized cellulosic samples by size exclusion chromatography (SEC). Different cellulose samples with various average degree of polymerization (DP) were first solubilized in this solvent system, with increasing TBAF rates, and then analyzed by SEC coupled to a refractive index detector (RID), using DMSO as mobile phase. (mdpi.com)
  • OBJECTIVE: The objective was to examine the effect of a solvent dimethyl sulfoxide (DMSO) on resin-dentin bond durability, as well as potential functional mechanisms behind the effect. (utu.fi)
  • Dimethyl sulfoxide is a good polar solvent for unsaturated, nitrogen-containing and aromatic compounds. (xuxi44.site)
  • MATERIALS AND METHODS dimethyl sulfoxide (DMSO) and ethanol, are used to increase the solubility but have some irremediable toxic effects.2) The Chemicals DMSO was obtained from Sigma (St main cosolvent used is DMSO (H3C)2S5O due to its solvent Quentin Fallavier, France). (scribd.com)
  • Dimethyl Sulfoxide, USP is also known as DMSO and is used as an excipient solvent. (spectrumchemical.com)
  • Dimethyl Sulfoxide, Reagent is an organosulfur, colorless liquid and is also known as DMSO. (grainger.com)
  • The function of dimethyl sulfoxide (DMSO) as both an electrophilic and nucleophilic reagent has been well established. (dtic.mil)
  • Dimethyl Sulfoxide, SpectroSolv (TM) This Spectrosolv grade product is suitable for ultraviolet spectrophotometry usage and exceeds the specification of an ACS grade quality reagent. (spectrumchemical.com)
  • The two dimethyl sulfoxide solvated rhodium(III) compounds, [Rh(dmso-kappa O)(5)(dmso-kappa S)](CF(3)SO(3))(3) (1 & 1* at 298 K and 100 K, respectively) and [Rh(dmso-kappa O)(3)(dmso-kappa S)(2)Cl](CF(3)SO(3))(2) (2), crystallize with orthorhombic unit cells in the space group Pna2(1) (No. 33), Z = 4. (diva-portal.org)
  • Spectrum carries a wide selection of sulfoxides online which are any of a class of organic compounds containing sulfur and oxygen. (spectrumchemical.com)
  • abstract = "Partially benzylamidated, amphipathic poly(γ-glutamic acid) (BzPGA) was synthesized from poly(γ-glutamic acid) (PGA) and benzylamine by direct amidation in dimethyl sulfoxide (DMSO). (elsevier.com)
  • The results show that the metal ion-oxygen bonding of dimethyl sulfoxide ligands is electrostatically dominated in those complexes and that the stretching force constants provide a useful measure of the relative trans-influence of the opposite ligands in hexa-coordinated Rh(III)-complexes. (diva-portal.org)
  • In addition to these conventional treatments for bursitis , a more natural approach that is currently growing in popularity uses dimethyl sulfoxide (DMSO), a chemical made from wood pulp that enters the skin and promotes the healing of areas affected by inflammation 2 . (wholesomeone.com)
  • Patients will typically be administered dimethyl sulfoxide via catheter or syringe with the dosage administered once every two weeks. (healthery.com)
  • Dimethyl sulfoxide (DMSO) added to agar overlays during plaque assays of simian virus 40 (SV40) in CV1 monkey cells increases the plaque size and number and enables plaques to be read several days earlier than usual. (biomedsearch.com)
  • Cells of a cloned line of murine virus-induced erythroleukemia were stimulated to differentiate along the erythroid pathway by dimethyl sulfoxide at concentrations that did not inhibit growth. (pnas.org)
  • Loss of detectability of Charcot-Leyden crystal protein transcripts in blood cells after treatment with dimethyl sulfoxide. (semanticscholar.org)
  • Dimethyl sulfoxide did not alter the morphology of endothelial cells or brain parenchyma. (ucl.ac.uk)
  • The aim of this study was to investigate whether dimethyl sulfoxide supplementation in the media of HepG2 cells would enhance metabolic functionality leading to the development of an improved in vitro cell model that closely recapitulates primary human hepatocyte metabolism. (ox.ac.uk)
  • HepG2 cells were cultured in media containing 1% dimethyl sulfoxide for 2, 4, 7, 14, and 21 days. (ox.ac.uk)
  • We have demonstrated that the addition of 1% dimethyl sulfoxide to culture media changes the metabolic phenotype of HepG2 cells toward a more primary human hepatocyte phenotype. (ox.ac.uk)
  • Fain, John N. / Effects of dimethylsulfoxide on cyclic AMP accumulation, lipolysis and glucose metabolism of fat cells . (elsevier.com)
  • Dimethyl sulfoxide (DMSO) is usually used to solubilize poorly soluble drugs in permeation assays such as that using Caco2 enterocyte-like cells. (scribd.com)
  • The medium was then removed, and the cells were solubilized in 200 [micro]L of dimethylsulfoxide and analyzed at 490 nm. (thefreedictionary.com)
  • In the room-temperature ionic liquid (IL) of 1-methyl-3-octylimidazolium bis(trifluoromethylsulfonyl)amide ([C 8 mim][TFSA]), the complex formation of Ni 2+ with molecular liquids (MLs), dimethyl sulfoxide (DMSO), methanol (MeOH), and acetonitrile (AN), has been examined using ultraviolet (UV)-visible spectroscopy. (rsc.org)
  • We perform molecular dynamics simulations, using OPLS/AA force field to investigate the physical solvation of glucose in four common solvents used in Biomass conversion studies, namely, water, Dimethylsulfoxide (DMSO), N,N-Dimethylformamide (DMF) and Tetrahydrofuran (THF). (ntu.edu.sg)
  • China Factory Dimethyl Sulfoxide (DMSO 99.9% MIN) (CAS No: 67-68-5) Hong Kong Jia Ying International Trade Co., Ltd. (schilderoord.nl)
  • In literature it has been reported that the gamma-phase PVDF film is formed from dimethyl sulfoxide (DMSO) solvents regardless of preparation temperature. (arxiv.org)
  • Spectrum specializes in providing the top sulfoxides if you do not see the product, grade, or form of the ingredient you require, just contact our chemical specialist at 800-772-8786. (spectrumchemical.com)
  • PURPOSE: To relate changes in the electrochemical impedance spectra to the progression and mechanism of skin damage arising from exposure to dimethyl sulfoxide (DMSO). (cdc.gov)
  • This study examined the mechanism of vasorelaxation induced by dimethyl sulfoxide (DMSO) in endothelium-intact and -denuded rat aorta. (researchmap.jp)
  • Dr. Jacob says, "Dimethyl sulfoxide in the laboratory blocks conduction in an isolated nerve when a 25% concentration is employed. (encognitive.com)