A drug combination that contains diphenhydramine and theophylline. It is used for treating VERTIGO, MOTION SICKNESS, and NAUSEA associated with PREGNANCY.
Drugs used to prevent NAUSEA or VOMITING.
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
Pathological development in the JEJUNUM region of the SMALL INTESTINE.
The forcible expulsion of the contents of the STOMACH through the MOUTH.
Facilities which provide information concerning poisons and treatment of poisoning in emergencies.

Rectally administered dimenhydrinate reduces postoperative vomiting in children after strabismus surgery. (1/14)

We have investigated the effectiveness of rectally administered dimenhydrinate on postoperative vomiting in children undergoing strabismus surgery, in a double-blind, randomized, placebo-controlled study. In one group, dimenhydrinate 50 mg was administered rectally 30 min before starting anaesthesia, whereas in the control group, placebo suppositories were given. Children who received dimenhydrinate showed a significantly (P < 0.001) lower incidence of vomiting (15%) than those in the control group (75%). We conclude that rectal administration of dimenhydrinate is an effective means of reducing postoperative vomiting in children undergoing strabismus surgery.  (+info)

A CLINICAL EVALUATION OF INTRAVENOUS DIMENHYDRINATE IN LABOUR. (2/14)

Dimenhydrinate was administered intravenously to patients in spontaneous labour in order to evaluate its effect on the length of labour, its analgesic property, its potentiation of the effects of standard analgesics and its overall safety. The results of this study provided no evidence that labour was shortened or that uterine activity was increased in those receiving intravenous dimenhydrinate, nor did this drug decrease the need for conventional analgesics. There were no maternal or fetal complications. It is concluded that intravenous administration of dimenhydrinate has no advantage over analgesics administered by other routes and has a limited use in current obstetrical practice.  (+info)

Experimental research on antimotion sickness effects of Chinese medicine "pingandan" pills in cats. (3/14)

Pingandan was a secret prescription for treatment of stomach upset, nausea and vomiting for emperors in the Qing Dynasty of China. This study was to compare the effects of Pingandan with those of scopolamine and dramamine on motion sickness (MS) and nystagmus. Fourteen cats were tested in a parallel swing (0.22 Hz, 3.9 m/S2) for 20 min, and then in a rotating chair (10 degrees/S2, 20 rpm) for 1-2 min. The effects of scopolamine 1 mg, dramamine 25 mg and three doses of Pingandan 50x, 30x, 10x of 0.45 g/kg were observed and compared to placebos. These drugs or placebos were administered to each cat 30-60 min prior to the tests. The post-rotary nystagmus and MS symptoms were recorded. The Suri's scale for MS severity, Latin square and double blind techniques were used. The interval between any two tests was 2-5 days. It was found that Pingandan 50x and scopolamine 1 mg were more effective than placebos in reducing MS symptoms (P less than 0.01) and suppressing slow phase velocity of nystagmus (P less than 0.05), while Pingandan 30x significantly reduced MS symptoms only (P less than 0.01). Pingandan 10x and dramamine 25 mg had no anti-MS effect. Chinese medicine Pingandan is an effective anti-MS drug.  (+info)

Contribution to the treatment of nausea and emesis induced by chemotherapy in children and adolescents with osteosarcoma. (4/14)

CONTEXT AND OBJECTIVE: Chemotherapy-induced emesis is a limiting factor in treating children with malignancies. Intensive chemotherapy regimens along with emetogenic drug administration have increased the frequency and severity of emesis and nausea. Our study was designed to consider the importance of this problem and the need for improvement in emesis treatment for patients receiving chemotherapy. Our objective was to compare the efficacy and safety of the antiemetic drug granisetron and a regimen of metoclopramide plus dimenhydrinate. DESIGN AND SETTING: Open, prospective and randomized study at Instituto de Oncologia Pediatrica, Department of Pediatrics, Universidade Federal de Sao Paulo. METHODS: From February to August 1994, 26 patients (mean age: 14 years) with osteosarcoma received 80 chemotherapy cycles of iphosphamide (2,500 mg/m2) plus epirubicin (75 mg/m2) or carboplatin (600 mg/m2), or epirubicin (75 mg/m2) plus carboplatin (600 mg/m2). Eighty chemotherapy treatments were analyzed regarding nausea and vomiting control. Patients were randomized to receive either a single dose of granisetron (50 microg/kg) or metoclopramide (2 mg/kg) plus dimenhydrinate (5 mg/kg infused over eight hours). Emesis and nausea were monitored for 24 hours by means of the modified Morrow Assessment of Nausea and Emesis. Statistical analysis utilized the chi-squared, Student t and Mann-Whitney tests, plus data exploration techniques. RESULTS: 62.5% of the patients undergoing chemotherapy responded completely to granisetron, whereas 10% responded to metoclopramide plus dimenhydrinate (p < 0.0001). No severe adverse reactions were found in either of the treatments given. CONCLUSION: In children and adolescents with osteosarcoma, granisetron was safe and more efficient than metoclopramide plus dimenhydrinate for controlling chemotherapy-induced emesis and nausea.  (+info)

Properties of pellets manufactured by wet extrusion/spheronization process using kappa-carrageenan: effect of process parameters. (5/14)

 (+info)

Protein S deficiency, epileptic seizures, sagittal sinus thrombosis and hemorrhagic infarction after ingestion of dimenhydrinate. (6/14)

Congenital protein S deficiency is associated with an increased risk of venous thrombosis. A14-year-old boy presented with epileptic seizures and thrombosis of the superior sagittal sinus and frontal hemorrhagic venous infarction after ingestion of 50 mg of dimenhydrinate, an antiemetic drug. The patient was found to be heterozygous for the factor V Leiden mutation and had a functional protein S deficiency. He recovered completely within a month after conservative treatment. Dimenhydrinate may have disrupted a subclinical pre-existing condition in this case.  (+info)

Diagnostic delay after dimenhydrinate use in vomiting children. (7/14)

OBJECTIVE: To determine whether the use of dimenhydrinate was associated with delay in the diagnosis and management of treatable illnesses or with direct adverse effects in children with vomiting presenting to an emergency department. DESIGN: Questionnaire survey and review of drug reaction and telephone inquiry records. SETTING: The emergency department of a tertiary care children's hospital and a provincial poison information centre. PATIENTS: The parents of 148 children who presented with vomiting completed the questionnaire. The database at the poison information centre included 474 reports of adverse drug reactions over an 8-year period and 105 reports of telephone inquiries over a 4-year period. MAIN RESULTS: Twenty-one (14%) of 148 children had received dimenhydrinate before arrival at the emergency department. The patients who had received dimenhydrinate were more likely than the others to present more than 12 hours after the onset of vomiting (14 [67%] of 21 v. 43 [34%] of 127, p less than 0.01). The discharge diagnoses for those who had received dimenhydrinate included asthma, pelvic inflammatory disease and urinary tract infection. No clinically important direct adverse reactions to dimenhydrinate were documented. CONCLUSIONS: The use of dimenhydrinate in children with vomiting is associated with a risk of delay in the diagnosis of treatable medical conditions.  (+info)

Dimenhydrinate in children with infectious gastroenteritis: a prospective, RCT. (8/14)

 (+info)

Dimenhydrinate is an antihistamine medication that is commonly used to prevent and treat motion sickness. It is a combination of diphenhydramine and 8-chlorotheophylline in a 50:50 ratio by weight. Diphenhydramine is an antihistamine with anticholinergic and sedative properties, while 8-chlorotheophylline is a mild stimulant that helps counteract the sedative effects of diphenhydramine.

Dimenhydrinate works by blocking the action of histamine, a substance in the body that causes allergic symptoms, as well as certain motion sickness-inducing signals in the brain. By doing so, it can help alleviate symptoms such as nausea, vomiting, and dizziness associated with motion sickness.

Dimenhydrinate is available over-the-counter and by prescription in various forms, including tablets, capsules, and liquid solutions. It is important to follow the dosage instructions carefully and talk to a healthcare provider before taking this medication if you have any medical conditions or are taking other medications.

Antiemetics are a class of medications that are used to prevent and treat nausea and vomiting. They work by blocking or reducing the activity of dopamine, serotonin, and other neurotransmitters in the brain that can trigger these symptoms. Antiemetics can be prescribed for a variety of conditions, including motion sickness, chemotherapy-induced nausea and vomiting, postoperative nausea and vomiting, and pregnancy-related morning sickness. Some common examples of antiemetic medications include ondansetron (Zofran), promethazine (Phenergan), and metoclopramide (Reglan).

A suppository is a solid medicinal formulation, often medicated, that is intended to be introduced into the rectum (rectal suppository), vagina (vaginal suppository), or urethra (urethral suppository) for absorption or for localized effect. Suppositories are designed to melt or dissolve at body temperature and release the active ingredients. They come in various shapes, such as cones, cylinders, or torpedo-shaped, and are typically made from a base of cocoa butter, polyethylene glycol, or other biocompatible materials that allow for controlled drug release. Common uses for suppositories include the treatment of constipation, hemorrhoids, local infections, menstrual cramps, and as an alternative method of administering medication for individuals who have difficulty swallowing pills or prefer not to use oral medications.

Jejunal diseases refer to a range of medical conditions that affect the jejunum, which is the middle section of the small intestine. These diseases can cause various symptoms such as abdominal pain, diarrhea, bloating, nausea, vomiting, and weight loss. Some examples of jejunal diseases include:

1. Jejunal inflammation or infection (jejunitis)
2. Crohn's disease, which can affect any part of the gastrointestinal tract including the jejunum
3. Intestinal lymphoma, a type of cancer that can develop in the small intestine
4. Celiac disease, an autoimmune disorder that causes damage to the small intestine when gluten is consumed
5. Intestinal bacterial overgrowth (SIBO), which can occur due to various reasons including structural abnormalities or motility disorders of the jejunum
6. Meckel's diverticulum, a congenital condition where a small pouch protrudes from the wall of the intestine, usually located in the ileum but can also affect the jejunum
7. Intestinal strictures or obstructions caused by scarring, adhesions, or tumors
8. Radiation enteritis, damage to the small intestine caused by radiation therapy for cancer treatment.

The diagnosis and management of jejunal diseases depend on the specific condition and its severity. Treatment options may include medications, dietary modifications, surgery, or a combination of these approaches.

Vomiting is defined in medical terms as the forceful expulsion of stomach contents through the mouth. It is a violent, involuntary act that is usually accompanied by strong contractions of the abdominal muscles and retching. The body's vomiting reflex is typically triggered when the brain receives signals from the digestive system that something is amiss.

There are many potential causes of vomiting, including gastrointestinal infections, food poisoning, motion sickness, pregnancy, alcohol consumption, and certain medications or medical conditions. In some cases, vomiting can be a symptom of a more serious underlying condition, such as a brain injury, concussion, or chemical imbalance in the body.

Vomiting is generally not considered a serious medical emergency on its own, but it can lead to dehydration and other complications if left untreated. If vomiting persists for an extended period of time, or if it is accompanied by other concerning symptoms such as severe abdominal pain, fever, or difficulty breathing, it is important to seek medical attention promptly.

Poison Control Centers are specialized organizations that provide immediate, free, and expert advice and treatment recommendations for exposure to potentially harmful substances, also known as poisons. They are staffed by trained healthcare professionals, including medical toxicologists, nurses, pharmacists, and poison information providers. These centers manage a wide range of poisoning cases, from accidental ingestions in children to intentional overdoses and chemical exposures in adults. They offer 24/7 emergency hotline services to the public, healthcare providers, and first responders for poison-related emergencies and provide valuable resources for poison prevention and education. The primary goal of Poison Control Centers is to reduce the morbidity and mortality associated with poison exposures and promote overall public health and safety.

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Dimenhydrinate for prophylaxis of postoperative nausea and vomiting. A meta-analysis of randomized controlled trials. Acta ...
Halpert AG, Olmstead MC, Beninger RJ (January 2002). "Mechanisms and abuse liability of the anti-histamine dimenhydrinate" (PDF ...
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  • Dimenhydrinate, sold under the brand name Dramamine, among others, is an over-the-counter medication used to treat motion sickness and nausea. (wikipedia.org)
  • Dimenhydrinate (in US marketed under brand names Dramamine , Driminate , Gravol , Gravamin , Vomex , and Vertirosan ) is an over-the-counter drug used to prevent nausea and motion sickness . (curecrowd.com)
  • While dimenhydrinate is still used to prevent nausea and emesis , the development of the chemical meclozine has overtaken its usage (marketed as "Dramamine II") because meclozine is less likely to cause drowsiness. (curecrowd.com)
  • Buy Dramamine 'Dimenhydrinate' Online Without Prescriptions. (buylevitra24h.com)
  • Cheap Dramamine 'Dimenhydrinate' Online No Prescription. (buylevitra24h.com)
  • Dimenhydrinate (Dramamine) abuse: hallucinogenic experiences with a pr. (erowid.org)
  • Dramamine or Bonine (dimenhydrinate or meclizine). (metafilter.com)
  • Commonly used medicines are diphenhydramine (Benadryl), dimenhydrinate (Dramamine), and scopolamine. (cdc.gov)
  • These include dimenhydrinate (brand name: Dramamine) and meclizine hydrochloride (brand name: Dramamine Less Drowsy). (familydoctor.org)
  • Buy some dimenhydrinate tablets (such as Dramamine) at your drug store. (stlouischildrens.org)
  • Dimenhydrinate is a theoclate salt composed of diphenhydramine (an ethanolamine derivative) and 8-chlorotheophylline (a chlorinated theophylline derivative) in a 1:1 ratio. (wikipedia.org)
  • Dimenhydrinate is a 1:1 salt of diphenhydramine and 8-chlorotheophylline. (janusinfo.se)
  • Dimenhydrinate is an antiemetics drug combination that contains diphenhydramine and theophylline. (lgmpharma.com)
  • Jaju BP, Wang SC: Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: a search for the locus of their antimotion sickness action. (lgmpharma.com)
  • The effects of dimenhydrinate are very similar to those of diphenhydramine . (curecrowd.com)
  • 50 mg dimenhydrinate contains 27.2 mg of diphenhydramine, so it is less potent at equal doses. (curecrowd.com)
  • Also, dimenhydrinate must dissociate into diphenhydramine and its counterion in the body before it is active, so it produces effects more slowly than diphenhydramine. (curecrowd.com)
  • Dimenhydrinate is an over-the-counter (OTC) antihistamine indicated for the prevention and relief of nausea and vomiting from a number of causes, including motion-sickness and post-operative nausea. (wikipedia.org)
  • Dimenhydrinate is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. (medlineplus.gov)
  • Adults and children older than age 12 may usually take dimenhydrinate every 4 to 6 hours as needed to prevent or treat motion sickness. (medlineplus.gov)
  • Children under age 12 may usually be given dimenhydrinate every 6 to 8 hours as needed to prevent or treat motion sickness. (medlineplus.gov)
  • Dimenhydrinate Tablets (Formerly Motion Relief)For nausea, dizziness and vomiting associated with motion sickness. (wonderlabs.com)
  • Dimenhydrinate is a medication that is used to prevent and treat motion sickness. (therecoveryvillage.com)
  • u003cbr\u003e\u003cbr\u003eThis product contains the active drug Dimenhydrinate, for the prevention and treatment of nausea, vomiting and dizziness due to motion sickness. (consumerschoicemedical.com)
  • As I understand it, and I've had a number of conversations with physicians of different disciplines regarding the same, dimenhydrinate is most effective for motion sickness, and other antiemetics exist that are typically more effective for the types of emesis that we typically deal with in the field. (sworbhp.ca)
  • Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines. (bvsalud.org)
  • Relative daytime drowsiness and performance impairment produced by meclizine and dimenhydrinate was assessed in 24 healthy male volunteers . (bvsalud.org)
  • Expressed as change from baseline, the greatest reductions in digit symbol substitution scores after dimenhydrinate occurred 3 hours after the first dose (6.6 +/- 7) and were not different from the greatest measured change after meclizine (5.8 +/- 8), which occurred 9 hours after the dose was administered. (bvsalud.org)
  • Self -rated sleepiness after dimenhydrinate was greatest 1 hour after the first dose , and was significantly greater than the largest degree of sleepiness after meclizine , which occurred at 7 hours after the dose . (bvsalud.org)
  • id":4688758997073,"title":"Gravol ~ Dimenhydrinate 50mg","handle":"gravol-50mg","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch2\u003eGravol ~ Dimenhydrinate 50mg\u003c\/h2\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003e10 Tablets\u003c\/strong\u003e\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eGravol Easy to Swallow Filmkote Tablets have a unique coating, which makes them easy to swallow with no aftertaste. (consumerschoicemedical.com)
  • If you are looking for the generic alternative to Gravol Long Action Dual Relief, please see: Dimenhydrinate - non Rx. (doctorsolve.com)
  • The information above for Gravol Long Action Dual Relief (Dimenhydrinate - non Rx) was provided to DoctorSolve.com by third parties. (doctorsolve.com)
  • Dimenhydrinate directly inhibits the stimulation of certain nerves in the brain and inner ear to suppress nausea, vomiting, dizziness, and vertigo. (lgmpharma.com)
  • Antiemetics: unrelated to our current directives but I was just wondering what the rationale was for specifically using dimenhydrinate as our prehospital antiemetic option? (sworbhp.ca)
  • Dimenhydrinate tablets/Antiemetic. (cub.com)
  • Dimenhydrinate is in a class of medications called antihistamines. (medlineplus.gov)
  • The effects of the first dose of dimenhydrinate on psychometric test scores were compared with the magnitude of the effects produced by subsequent doses. (bvsalud.org)
  • The magnitude of effect of the first dose of dimenhydrinate was significantly greater than the magnitude of effect produced by subsequent doses. (bvsalud.org)
  • The data suggest the possibility that acute tolerance to central nervous system impairment develops with multiple doses of dimenhydrinate . (bvsalud.org)
  • If you are taking dimenhydrinate chewable tablets, talk to your doctor if you are allergic to tartrazine (FD&C Yellow No. 5, a color additive) or aspirin. (medlineplus.gov)
  • Dimenhydrinate is also sometimes used to treat Meniere's disease (condition of the inner ear which causes extreme dizziness, loss of balance, ringing in the ears, and hearing loss) and other inner ear problems. (medlineplus.gov)
  • Limit intake of alcoholic beverages as it increases drowsiness and dizziness while you are taking dimenhydrinate. (premiumpillsprice.com)
  • Dimenhydrinate is a competitive antagonist at the histamine H1 receptor, which is widely distributed in the human brain. (lgmpharma.com)
  • Halpert AG, Olmstead MC, Beninger RJ: Mechanisms and abuse liability of the anti-histamine dimenhydrinate. (lgmpharma.com)
  • Active substance of the drug is Dimenhydrinate, it blocks histamine H1-receptors and m-cholinergic receptors of central nervous system, inhibits hyperstimulated functioning of the labyrinth. (premiumpillsprice.com)
  • Dimenhydrinate comes as a tablet and chewable tablet to take by mouth with or without food. (medlineplus.gov)
  • Anaphylaxis to Dimenhydrinate Caused by the Theophylline Component. (jiaci.org)
  • Dimenhydrinate also reduces depressive effect of acetylcholine on the heart muscle. (premiumpillsprice.com)
  • avoid alcoholic beverages or products containing alcohol while taking dimenhydrinate. (medlineplus.gov)
  • Alcohol can make the side effects from dimenhydrinate worse. (medlineplus.gov)
  • When someone takes more of the drug than recommended, dimenhydrinate can cause psychotropic effects including hallucinations and euphoria. (therecoveryvillage.com)
  • Stopping dimenhydrinate use after the body becomes used to the drug can cause undesirable effects. (therecoveryvillage.com)
  • Dimenhydrinate is an antihistamine that is purchasable without a prescription. (therecoveryvillage.com)
  • Disagreements between the two reobserveers were resolved at hand a majority appreciation after Buy Arjuna 60Caps Online Without Prescription a order dimenhydrinate online no prescription third reoverer assessed all active items. (upb.ro)
  • The correlation coefficients were calculated from a scatter plot of the ADC and tumor chamberularity arisest cases in which the order dimenhydrinate online no prescription correlation coefficients were not reported. (upb.ro)
  • Dimenhydrinate may also be used to treat inner ear problems that cause balance issues. (therecoveryvillage.com)
  • Medications that are used to treat dimenhydrinate withdrawal can only help manage the symptoms. (therecoveryvillage.com)
  • talk with your doctor and pharmacist if you are allergic to dimenhydrinate, any other medications, or any of the ingredients in the dimenhydrinate preparation. (medlineplus.gov)
  • Similar to other drugs that are abused, when people stop taking dimenhydrinate they can experience withdrawal symptoms. (therecoveryvillage.com)
  • Dimenhydrinate withdrawal symptoms are similar to other drugs of abuse. (therecoveryvillage.com)
  • Depending on how long the person was taking dimenhydrinate for and how much they took determines the severity of the withdrawal symptoms. (therecoveryvillage.com)
  • Managing the symptoms of dimenhydrinate withdrawal is difficult and should be done with the help of a medical professional. (therecoveryvillage.com)
  • Supportive care or managing the symptoms of withdrawal is the standard of care for dimenhydrinate detox. (therecoveryvillage.com)
  • Once the symptoms of withdrawal are gone, therapy should be considered to help the person stay off of dimenhydrinate. (therecoveryvillage.com)
  • According to the European Medicines Agency guideline on environmental risk assessment of medicinal products (EMA/CHMP/SWP/4447/00), use of dimenhydrinate is unlikely to represent a risk for the environment, because the predicted environmental concentration (PEC) is below the action limit 0,01 μg/L. (janusinfo.se)
  • if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability), read the package label carefully before taking dimenhydrinate. (medlineplus.gov)
  • If you become pregnant while taking dimenhydrinate, call your doctor. (medlineplus.gov)
  • Do not give dimenhydrinate to children younger than 2 years of age unless your doctor has told you to do so. (medlineplus.gov)
  • The original medical condition may need to be treated once dimenhydrinate use is stopped. (therecoveryvillage.com)
  • People who are withdrawing from dimenhydrinate need to be in a supportive environment. (therecoveryvillage.com)