Cell Communication: Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Gap Junctions: Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.Communication: The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Intercellular Junctions: Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Connexins: A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.Coculture Techniques: A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Animal Communication: Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Communication Disorders: Disorders of verbal and nonverbal communication caused by receptive or expressive LANGUAGE DISORDERS, cognitive dysfunction (e.g., MENTAL RETARDATION), psychiatric conditions, and HEARING DISORDERS.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Health Communication: The transfer of information from experts in the medical and public health fields to patients and the public. The study and use of communication strategies to inform and influence individual and community decisions that enhance health.Communication Aids for Disabled: Equipment that provides mentally or physically disabled persons with a means of communication. The aids include display boards, typewriters, cathode ray tubes, computers, and speech synthesizers. The output of such aids includes written words, artificial speech, language signs, Morse code, and pictures.Sex Differentiation: The process in developing sex- or gender-specific tissue, organ, or function after SEX DETERMINATION PROCESSES have set the sex of the GONADS. Major areas of sex differentiation occur in the reproductive tract (GENITALIA) and the brain.Nonverbal Communication: Transmission of emotions, ideas, and attitudes between individuals in ways other than the spoken language.Embryonic Stem Cells: Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cell Lineage: The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Communication Barriers: Those factors, such as language or sociocultural relationships, which interfere in the meaningful interpretation and transmission of ideas between individuals or groups.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Physician-Patient Relations: The interactions between physician and patient.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Mice, Inbred C57BLOsteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Osteogenesis: The process of bone formation. Histogenesis of bone including ossification.Connexin 43: A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.Homeodomain Proteins: Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Antigens, Differentiation: Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.Computer Communication Networks: A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Mesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Adipogenesis: The differentiation of pre-adipocytes into mature ADIPOCYTES.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Radiology Information Systems: Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of radiology services and facilities.Cell Culture Techniques: Methods for maintaining or growing CELLS in vitro.Myoblasts: Embryonic (precursor) cells of the myogenic lineage that develop from the MESODERM. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes (MYOCYTES, SKELETAL; MYOCYTES, CARDIAC; MYOCYTES, SMOOTH MUSCLE).In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Keratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Trans-Activators: Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Embryo, Mammalian: The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.Muscle Development: Developmental events leading to the formation of adult muscular system, which includes differentiation of the various types of muscle cell precursors, migration of myoblasts, activation of myogenesis and development of muscle anchorage.Adipocytes: Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Hospital Communication Systems: The transmission of messages to staff and patients within a hospital.Interdisciplinary Communication: Communication, in the sense of cross-fertilization of ideas, involving two or more academic disciplines (such as the disciplines that comprise the cross-disciplinary field of bioethics, including the health and biological sciences, the humanities, and the social sciences and law). Also includes problems in communication stemming from differences in patterns of language usage in different academic or medical disciplines.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Basic Helix-Loop-Helix Transcription Factors: A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Epidermis: The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Repressor Proteins: Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.HL-60 Cells: A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)Bone Morphogenetic Proteins: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Leukemia, Erythroblastic, Acute: A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Mesoderm: The middle germ layer of an embryo derived from three paired mesenchymal aggregates along the neural tube.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Communication Methods, Total: Utilization of all available receptive and expressive modes for the purpose of achieving communication with the hearing impaired, such as gestures, postures, facial expression, types of voice, formal speech and non-speech systems, and simultaneous communication.Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 220.127.116.11.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Nerve Tissue ProteinsMyoD Protein: A myogenic regulatory factor that controls myogenesis. Though it is not clear how its function differs from the other myogenic regulatory factors, MyoD appears to be related to fusion and terminal differentiation of the muscle cell.Receptors, Notch: A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Morphogenesis: The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.Bone Morphogenetic Protein 2: A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
The pathway regulates the proliferation, differentiation, and death of cells. Signals are transduced by the cell-surface ... Notch signalling is an important pathway involved in cell-cell communication. ... rabconnectin-3a is involved in neural crest migration by playing a role in endosomal maturation in neural crest cells. The DmX ... Developmental Cell. 17 (3): 387-402. doi:10.1016/j.devcel.2009.07.001. Kraemer, Christiane; Enklaar, Thorsten; Zabel, Bernhard ...
... cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM. ... cell migration, cell proliferation, differentiation and cell death (apoptosis). Inhibition of nonmuscle myosin ... Effect on differentiation. ECM elasticity can direct cellular differentiation, the process by which a cell changes from ... Cell adhesion. Many cells bind to components of the extracellular matrix. Cell adhesion can occur in two ways; by focal ...
"Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation". Nature Communications. 2 (5): 314. doi: ... He was the first to describe the role of T cells in immunoglobulin class switching and to identify a novel T-cell-derived ... "Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease". J. Clin ... Hovhannisyan, Z; Treatman, J; Littman, D; Mayer, L (2011). "Characterization of IL-17-producing regulatory T cells in inflamed ...
"ECM-induced gap junctional communication enhances mammary epithelial cell differentiation". J. Cell Sci. 116 (Pt 17): 3531-41. ... "Differentiation of human fetal osteoblastic cells and gap junctional intercellular communication". Am. J. Physiol., Cell ... Barbe, M. T. (1 April 2006). "Cell-Cell Communication Beyond Connexins: The Pannexin Channels". Physiology. 21 (2): 103-114. ... Junctional membrane structure of hybrids between communication-competent and communication-incompetent cells". J. Membr. Biol. ...
Discoidin domain-containing receptor 2
cell adhesion. • positive regulation of osteoblast differentiation. • chondrocyte proliferation. • positive regulation of cell ... RTKs play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation ... Proteins: clusters of differentiation (see also list of human clusters of differentiation) ... Cell Genet. 61 (4): 274-5. doi:10.1159/000133421. PMID 1486804.. *. Abedinia M, Layfield R, Jones SM, Nixon PF, Mattick JS ( ...
Gazit R, Krizhanovsky V, Ben-Arie N (Feb 2004). "Math1 controls cerebellar granule cell differentiation by regulating multiple ... Biochemical and Biophysical Research Communications. 344 (4): 1166-71. doi:10.1016/j.bbrc.2006.03.238. PMID 16647036. Mutoh H, ... Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian ... Du X, Jensen P, Goldowitz D, Hamre KM (May 2007). "Wild-type cells rescue genotypically Math1-null hair cells in the inner ears ...
Discoidin domain-containing receptor 2
... is a receptor tyrosine kinase (RTK). RTKs play a key role in the communication of cells ... These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the ... extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells". Mol. Cell. Biochem. ... Cell Dev. Biol. 27: 265-90. doi:10.1146/annurev-cellbio-092910-154013. PMID 21568710. Ikeda K, Wang LH, Torres R, Zhao H, Olaso ...
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are ... Cell Growth & Differentiation. 5 (11): 1173-83. PMID 7848919. Kato JY, Matsuoka M, Strom DK, Sherr CJ (Apr 1994). "Regulation ... involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is ... Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene. ...
... undergo cell differentiation through a variety of mechanisms based on cell-cell communication. Suberites are key ... Suberites consist of many telomerase-positive cells, which means the cells are essentially immortal, barring cell death signal ... Differentiation capacity of epithelial cells in the sponge Suberites domuncula. Cell & Tissue Research 316, 271 (2004). H. C. ... Cell Death & Differentiation 18, 201 (2011). G. Zheng, L. Binglin, Z. Chengchao, W. Guangyi, Molecular Detection of Fungal ...
Complexity in bacterial cell-cell communication: quorum signal integration and subpopulation signaling in the Bacillus subtilis ... with cell differentiation and task distribution. Accomplishing such intricate cooperative ventures requires sophisticated cell- ... Cell 2006, 125:237-246. Ben-Jacob E, Becker I, Shapira Y, Levine H: Bacterial linguistic communication and social intelligence ... cell communication including semantic and pragmatic aspects of linguistics. Communicating with each other using a variety of ...
PP2A activity promotes the stem cells renewal ability during the differentiation process. When CRABP1 was knocked down the ... during human monocyte differentiation in vitro". Biochemical and Biophysical Research Communications. 248 (3): 830-4. doi: ... that induces apoptosis of cancer cells and lengthens the cell cycle of embryonic stem cells. ... CRABP1 activity can thus extend the cell cycle, e.g. in embryonic and neural stem cells. Knockout mice without CRABP1 showed ...
Bone morphogenetic protein 3
"Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation". Biochemical and ... Biophysical Research Communications. 241 (3): 787-93. doi:10.1006/bbrc.1997.7792. PMID 9434787. Daluiski A, Engstrand T, ... BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured ...
"Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions". Biochemical and Biophysical Research ... Biochemical and Biophysical Research Communications. 343 (1): 8-14. doi:10.1016/j.bbrc.2006.02.116. PMID 16527254. Pharmacy and ... It is also used to induce hypoxia-like environment in mesenchymal stem cells. Chelation therapy "Deferoxamine Mesylate". The ... Deferoxamine may modulate expression and release of inflammatory mediators by specific cell types. Deferoxamine is being ...
Sperm-associated antigen 1
... whose expression is induced with differentiation of spermatogenic cells". Biochemical and Biophysical Research Communications. ... This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature ... "Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells". Oncogene. 26 ...
... cell polarity and location controls the balance of neuronal progenitor cell maintenance and differentiation in the developing ... Nature Communications. 5: 3399. doi:10.1038/ncomms4399. ... of differentiation and the emergence of alternative cells ... It was at this point she began to become interested in how the timing of neuronal differentiation is controlled. In 1997, Nancy ... Her own work, and that of her lab members, focused on understanding how the cell cycle, ...
Vitisin A (stilbenoid)
"Vitisin a inhibits adipocyte differentiation through cell cycle arrest in 3T3-L1 cells". Biochemical and Biophysical Research ... Communications. 372 (1): 108-113. doi:10.1016/j.bbrc.2008.04.188. PMID 18482581. Mi Jeong Sung, S.; Davaatseren, M.; Kim, W.; ... and NF-κB activation in RAW 264.7 cells". International Immunopharmacology. 9 (3): 319-323. doi:10.1016/j.intimp.2008.12.005. ...
... s likely constitute a hub for the coordination of cell signaling and communication. The CCN protein family includes ... differentiation, survival, apoptosis, and senescence. They are also involved in biological processes including angiogenesis, ... Perbal B (August 2013). "CCN proteins ; A Centralized Communication Network". J. Cell. Commun. Signal. 7 (3): 169-77. doi: ... Cell Biol. 41 (4): 771-83. doi:10.1016/j.biocel.2008.07.025. PMC 2668982 . PMID 18775791. Holbourn KP, Acharya KR, Perbal B ( ...
Two transmembrane proteins implicated in cell-cell communication". The International Journal of Biochemistry & Cell Biology. 44 ... a robo-related cell surface protein that mediates myogenic differentiation". The Journal of Cell Biology. 143 (2): 403-13. PMID ... "The Shh coreceptor Cdo is required for differentiation of midbrain dopaminergic neurons". Stem Cell Research. 13 (2): 262-74. ... there is evidence showing its role in mediating the effects of cell-cell interactions between muscle precursors that are ...
3D cell culture
The spheroids are thus improved models for cell migration, differentiation, survival, and growth. Furthermore, 3D cell cultures ... 3D spheroids more closely resemble in vivo tissue in terms of cellular communication and the development of extracellular ... cell-cell/cell-matrix interaction, and/or cell migration, but the available assays are not optimized for 3D cell culturing. The ... In living tissue, cells exist in 3D microenvironments with intricate cell-cell and cell-matrix interactions and complex ...
Pancreatic progenitor cell
Zaret, K. S. (2008). "Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation". Nature ... Biochemical and Biophysical Research Communications. 392 (3): 247-251. doi:10.1016/j.bbrc.2009.12.115. ... Endocrine lineages develop into Delta cells, PP-cells, Epsilon cells, Beta cells and Alpha cells. Alpha cells produce glucagon ... Exocrine cells constitute the acinar cells and the ductal cells. The endocrine cells constitute the beta cells which make ...
The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a ... Biochemical and Biophysical Research Communications. 132 (1): 100-9. doi:10.1016/0006-291X(85)90994-5. PMID 2998351. Gondo H, ... blood-cell precursor) stem cells of bone marrow. Work with cell cultures and experiments with animals have shown that ... Adhesion to endothelial cells of blood vessel walls is pre-requisite for these cells to leave the bloodstream and invade ...
ATOH1 - ويكيبيديا
auditory receptor cell fate determination. • تمايز خلوي. • positive regulation of auditory receptor cell differentiation. • ضبط ... Biochemical and Biophysical Research Communications. 344 (4): 1166-71. doi:10.1016/j.bbrc.2006.03.238. PMID 16647036.. الوسيط , ... auditory receptor cell differentiation. • inner ear morphogenesis. • positive regulation of neuron differentiation. • neuron ... positive regulation of inner ear receptor cell differentiation. • negative regulation of apoptotic process. • neuron migration ...
NOV regulates multiple cellular activities including cell adhesion, migration, proliferation, differentiation, and survival. It ... Journal of Cell Communication and Signaling. 6 (1): 27-35. doi:10.1007/s12079-011-0142-2. PMC 3271200 . PMID 21773872. ... it was reported that the NOV protein was involved in regulatory T cell-mediated oligodendrocyte differentiation in the ... It is essential for self-renewal of CD34+ hematopoietic stem cells from umbilical cord blood. NOV can bind BMP2 and inhibit its ...
THP-1 cell line
"A cell line model for the differentiation of human dendritic cells". Biochemical and Biophysical Research Communications. 333 ( ... Cultures should be maintained at cell densities in the range 2-9x105 cells/ml at 37 °C, 5% CO2. Cells are non-adherent. Cell ... These cells show a large, round, single-cell morphology. They are derived from the peripheral blood of a 1 year old human male ... THP-1 is a human monocytic cell line derived from an acute monocytic leukemia patient. It is used to test leukemia cell lines ...
Some cell-cell communication requires direct cell-cell contact. Some cells can form gap junctions that connect their cytoplasm ... This requirement for direct contact allows for very precise control of cell differentiation during embryonic development. In ... Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells ... Sometimes autocrine cells can target cells close by if they are the same type of cell as the emitting cell. An example of this ...
... acid receptor subtypes and cellular retinoic acid binding protein-II mRNAs during differentiation of human trophoblast cells". ... Biochemical and Biophysical Research Communications. 315 (2): 428-33. doi:10.1016/j.bbrc.2004.01.069. PMID 14766225. ... Structures such as the limbs, hindbrain and cranial neural crest cells have been shown to be excessively sensitive to high ... Sanquer S, Eller MS, Gilchrest BA (Feb 1993). "Retinoids and state of differentiation modulate CRABP II gene expression in a ...
... cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. This signaling can influence the cell ... cycle and cellular differentiation. In addition to releasing signaling molecules into their environment to initiate quorum ... 2002). "General Principles of Cell Communication". In NCBI bookshelf. Molecular biology of the cell (4th ed.). New York: ... Cell adhesion, mechanical adhesion between cells and/or the extracellular matrix Role of cell adhesions in neural development ...
Notch signaling pathway
Lai EC (Mar 2004). "Notch signaling: control of cell communication and cell fate". Development. 131 (5): 965-73. doi:10.1242/ ... suggesting that Notch is involved in the differentiation of cardiac neural crest cells into vascular cells during outflow tract ... The Notch signaling pathway is important for cell-cell communication, which involves gene regulation mechanisms that control ... The Notch signaling pathway plays an important role in cell-cell communication, and further regulates embryonic development. ...
Cell cycle and differentiation In vitro experiments using both human and mouse cell lines have shown that EVI1 prevents the ... Biochemical and Biophysical Research Communications. 292 (3): 609-16. doi:10.1006/bbrc.2002.6693. PMID 11922610. Barjesteh van ... cell line and growth conditions being used as to whether EVI1 expression induces growth arrest or cell differentiation/ ... has also been shown in vitro to upregulate the cell cycle and block granulocytic differentiation of murine hematopoietic cells ...
T细胞 - 维基百科，自由的百科全书
T Cells to protect tumour cells. Nature Communications. March 2018, 9 (1): 948. PMC 5838096. PMID 29507342. doi:10.1038/s41467- ... Exhaustive differentiation of alloreactive CD8+ T cells: critical for determination of graft acceptance or rejection (PDF). ... 细胞毒性T细胞(CTLs, killer T cells)负责杀伤被病毒感染的细胞和癌细胞，在对器官移植的免疫排斥中也有参与。其特点在于细胞表面的CD8蛋白质。它通过识别所有有核细胞表
Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells.[ ... 2006). The ACS Style Guide: Effective Communication of Scientific Information (3rd ed.). Washington, D.C.: American Chemical ... Due to planetary differentiation, the core region is believed to be primarily composed of iron (88.8%), with smaller amounts of ... The balance between potassium and sodium is maintained by ion transporter proteins in the cell membrane. The cell membrane ...
... happens in serotonergic cells such as neurons. This is part of the differentiation of the serotonergic cells. This post- ... "Nature Communications. 7: 10966. Bibcode:2016NatCo...710966W. doi:10.1038/ncomms10966. PMC 4802181. PMID 26997247.. ... SLBP levels are controlled by cell-cycle proteins, causing SLBP to accumulate as cells enter S phase and degrade as cells leave ... "Cell. 148 (4): 664-78. doi:10.1016/j.cell.2011.12.029. PMC 3281992. PMID 22325148.. ...
Brain-derived neurotrophic factor
"Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development". Development. 134 ... and cognitive stimulation all translates into more neuronal activity and synaptic communication, which can produce structural ... cell-cell signaling. • positive regulation of brain-derived neurotrophic factor receptor signaling pathway. • collateral ... regulation of neuron differentiation. • neuron projection morphogenesis. • modulation of chemical synaptic transmission. • ...
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... altering the behavior or differentiation of nearby cells. Intracrine Local hormone Endocrine system Pandit, Nikita K. (2007). ... These T cells can then go on to perform effector functions such as macrophage activation, B cell activation, and cell-mediated ... When interleukin-1 is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that ...
... intracellular communication and signalling by cross-linking the protein actin to allow direct communication between the cell ... cell differentiation. • signal transduction. • keratinocyte development. Sources:Amigo / QuickGO. Orthologs. Species. Human. ... cell cortex. • focal adhesion. • extracellular matrix. • cytosol. • cell nucleus. • neuron projection. • neuronal cell body. ... 2001). "Filamins as integrators of cell mechanics and signalling". Nat. Rev. Mol. Cell Biol. 2 (2): 138-45. doi:10.1038/ ...
Interview by CDD". Cell Death and Differentiation. 12 (9): 1167-77. doi:10.1038/sj.cdd.4401691. PMID 16094393.. ... "Nature Communications. 9 (1): 1360. doi:10.1038/s41467-018-03785-w. PMC 5893597. PMID 29636472.. ... Interview by CDD". Cell Death and Differentiation. 12 (9): 1158-61. doi:10.1038/sj.cdd.4401709. PMID 16094391.. ... Interview by CDD". Cell Death and Differentiation. 12 (9): 1167-77. doi:10.1038/sj.cdd.4401691. PMID 16094393.. ...
Various types of CD30-positive T cell lymphomas. *CD30-positive cases of the NK cell lymphoma, extranodal NK/T-cell ... Proteins: clusters of differentiation (see also list of human clusters of differentiation) ... Biochemical and Biophysical Research Communications. 233 (3): 592-600. doi:10.1006/bbrc.1997.6509. PMID 9168896.. ... "Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population". ...
Neurons are cells specialized for communication. They are able to communicate with neurons and other cell types through ... These questions include the patterning and regionalization of the nervous system, neural stem cells, differentiation of neurons ... These questions include how signals are processed by neurites - thin extensions from a neuronal cell body, consisting of ... the cell bodies of the neurons containing the nucleus), and how neurotransmitters and electrical signals are used to process ...
Platelet-derived growth factor
... and differentiation, MSCs were shown to have stronger osteogenic differentiation into bone-forming cells when stimulated by ... "New Stanford molecular target for diabetes treatment discovered - Office of Communications & Public Affairs - Stanford ... PDGF is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells. In ... "Cell Death and Control of Cell Survival in the Oligodendrocyte Lineage". Cell. 70 (1): 31-46. doi:10.1016/0092-8674(92)90531-G ...
Epigenetics of neurodegenerative diseases
351 represses BACE1 expression in mouse BV-2 microglial cells". primary. Biochemical and Biophysical Research Communications. ... is negatively correlated with dopaminergic neuron differentiation in the midbrain. miR-7 and miR-153 act to reduce alpha- ... doi:10.1016/j.cell.2007.01.033. PMID 17320505.. *^ a b c Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, ... The Journal of Cell Biology. 191 (2): 367-81. doi:10.1083/jcb.201008051. PMC 2958468. PMID 20937701.. ...
Epigenetic modifications regulate the transition from neural stem cells to glial progenitor cells (for example, differentiation ... "Nature Communications. 5: 5055. PMC 4190663 . PMID 25268848. doi:10.1038/ncomms6055.. *^ Chahwan R, Wontakal SN, Roa S (March ... Costa S, Shaw P (March 2007). "'Open minded' cells: how cells can change fate" (PDF). Trends Cell Biol. 17 (3): 101-6. PMID ... Adult stem cells like bone marrow stem cells have also shown a potential to differentiate into cardiac competent cells when ...
Allison, Jeremy D.; Carde, Ring T. (2016). Pheromone Communication in Moths: Evolution, Behavior, and Application. Univ of ... Yeh, F.C.; Arnott, J.T. (1986). "Electrophoretic and morphological differentiation of Picea sitchensis, Picea glauca, and their ... The picture shows the structure of spruce tree cells. Spruce belongs to the genus of coniferous evergreen trees of the pine ... Without cones, morphological differentiation among spruce species and their hybrids is more difficult. Species classification ...
... occurred due to a transition from temporal to spatial cell differentiation, rather than through a gradual evolution of cell ... cell fusion molecules are viral in origin suggests that they have been vitally important to the inter-cellular communication ... Jamin, M, H Raveh-Barak, B Podbilewicz, FA Rey (2014) "Structural basis of eukaryotic cell-cell fusion" (Cell, Volume 157, ... Chen, L.; Xiao, S.; Pang, K.; Zhou, C.; Yuan, X. (2014). "Cell differentiation and germ-soma separation in Ediacaran animal ...
... "settlement cells" were linked by familial or clan relationships. Settlement cells were the basis of the simplest form of ... "need for self-identification in order to manifest their differentiation from other groups". ... times of shifting political alliances both with the Byzantine Empire and the kingdom of the East Franks and the communication ...
"Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1)". Proc. Natl. Acad. ... Nature Communications. 8: 14728. doi:10.1038/ncomms14728. PMID 28317845.. ... regulation of mitotic cell cycle. • intestinal epithelial cell maturation. • cellular response to ionizing radiation. • cell ... G2/M transition of mitotic cell cycle. • positive regulation of B cell proliferation. • negative regulation of cell growth. • ...
"Nature Communications. 8: 16047. Bibcode:2017NatCo...816047S. doi:10.1038/ncomms16047. PMC 5543309. PMID 28763051.. ... These give rise to egg cells. The gynoecium of a flower is also described using an alternative terminology wherein the ... This occurs as biochemical changes take place to change cellular differentiation of leaf, bud and stem tissues into tissue that ...
Communication. Like all domestic dogs, dingoes tend towards phonetic communication. However, in contrast to domestic dogs ... "Cell Research. 26 (1): 21-33. doi:10.1038/cr.2015.147. PMC 4816135. PMID 26667385.. ... can be used for differentiation. Despite all the characteristics that can be used for distinguishing between dingoes and other ... Aside from vocal communication, dingoes communicate, like all domestic dogs, via scent marking specific objects (for example, ...
Evolution of nervous systems
... suggesting the importance of these proto-synaptic proteins for cell to cell communication. The history of ideas on how ... In insects, many neurons have cell bodies that are positioned at the edge of the brain and are electrically passive-the cell ... "Neurobiology: molecules, cells, and systems. Wiley-Blackwell. p. 21. ISBN 978-0-632-04496-2. .. .mw-parser-output cite.citation ... Although sponge cells do not show synaptic transmission, they do communicate with each other via calcium waves and other ...
... channels in the cell walls that enable communication and transport). Heritability comes from methylation of promoters ... Differentiation. 73 (6): 287-93. doi:10.1111/j.1432-0436.2005.00029.x. PMID 16138829. S2CID 41117614.. ... Cullen LM, Arndt GM (June 2005). "Genome-wide screening for gene function using RNAi in mammalian cells". Immunology and Cell ... RNAi is a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells ...
Communication and signalingEdit. Main article: Animal communication. Communication is varied at all scales of life, from ... construct brood cells, and stock the cells with pollen and nectar before they lay their eggs, so when the larvae hatch they are ... Duffy, Emmett J.; Cheryl L. Morrison; Kenneth S. Macdonald (April 2002). "Colony defense and behavioral differentiation in the ... The nature of communication poses evolutionary concerns, such as the potential for deceit or manipulation on the part of the ...
Cells lining the walls of these ventricles contain fine filaments, and the cells are covered with a fine gelatinous layer. Each ... "National institute of deafness and other communication disorders. Retrieved 20 March 2016.. ... pouch syndrome associates middle ear anomalies to the malleus and incus structures as well as to the non-differentiation of the ... The microscopic "hairs" of these cells are structural protein filaments that project out into the fluid. The hair cells are ...
Kumar, S (2006). "Caspase function in programmed cell death". Cell Death and Differentiation. 14 (1): 32-43. doi:10.1038/sj.cdd ... Biochemical and Biophysical Research Communications. 285 (5): 1150-4. doi:10.1006/bbrc.2001.5315. PMID 11478774.. ... There are other identified roles of caspases such as cell proliferation, tumour suppression, cell differentiation, neural ... "Cell Death & Differentiation. 22 (4): 526-539. doi:10.1038/cdd.2014.216. ISSN 1350-9047. PMC 4356345. PMID 25526085.. ...
In order for a normal cell to transform into a cancer cell, the genes that regulate cell growth and differentiation must be ... "Cell Communication and Signaling. 9 (18): 18. doi:10.1186/1478-811X-9-18. PMC 3180438. PMID 21914164. Archived from the ... Germ cell tumor: Cancers derived from pluripotent cells, most often presenting in the testicle or the ovary (seminoma and ... "Cell. 126 (3): 477-87. doi:10.1016/j.cell.2006.05.051. PMC 2593932. PMID 16901782.. ...
Male germ cells mutate at a much faster rate than female germ cells, and as the father ages, the DNA of the germ cells mutates ... communications. "Cleft Lip and Cleft Palate". American Academy of Otolaryngology-Head and Neck Surgery. Retrieved 2016-03-16.. ... In respect of an etiology, sexual distinctions can be divided on appearing before and after differentiation of male's gonads in ... This is because, as humans age, male germ cells acquire mutations at a much faster rate than female germ cells. ...
... as well as differentiation and cell adhesion. It has been noted that tTG may have very different activity in different cell ... Biochemical and Biophysical Research Communications. 239 (2): 357-66. CiteSeerX 10.1.1.483.2738. doi:10.1006/bbrc.1997.7409. ... cell membrane. • extracellular matrix. • collagen-containing extracellular matrix. Biological process. • apoptotic cell ... "The Journal of Cell Biology. 148 (4): 825-38. doi:10.1083/jcb.148.4.825. PMC 2169362. PMID 10684262.. ...
Cell. 19 (2): R55-R56.. *^ a b Jurkevitch, Edouard; Davidov, Yaacov (2006). "Phylogenetic Diversity and Evolution of Predatory ... "Nature Communications. 6: 8285. Bibcode:2015NatCo...6.8285S. doi:10.1038/ncomms9285. PMC 4595633. PMID 26393325.. ... "Nature Communications. 7: 11034. doi:10.1038/ncomms11034. PMC 4820543. PMID 27023457. Cursorial hunting strategies range from ... Predation has evolved repeatedly in different groups of organisms. The rise of eukaryotic cells at around 2.7 Gya, the ...
Mir-181 microRNA precursor
"The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation". Nature Cell Biology. 8 (3 ... Biochemical and Biophysical Research Communications. 334 (4): 1351-8. doi:10.1016/j.bbrc.2005.07.030. PMID 16039986. Conti A, ... "miR-181a is an intrinsic modulator of T cell sensitivity and selection". Cell. 129 (1): 147-61. doi:10.1016/j.cell.2007.03.008 ... miR-181a is essential for the survival of Purkinje cells and its absence leads to a slow degeneration of these cells. It has ...
"The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program". ... Biochemical and Biophysical Research Communications. 294 (4): 900-5. doi:10.1016/S0006-291X(02)00551-X. PMID 12061792.. ... cell junction. • cytoplasm. • plasma membrane. Biological process. • negative regulation of cell-cell adhesion. • positive ... cell adhesion molecule binding. • cadherin binding. • identical protein binding. Cellular component. • cell-cell adherens ...
Nitric oxide synthase
Neuronal NOS also performs a role in cell communication and is associated with plasma membranes. nNOS action can be inhibited ... Liu Y, Feng Q (July 2012). "NOing the heart: role of nitric oxide synthase-3 in heart development". Differentiation. 84 (1): 54 ... It is synthesized by many cell types in response to cytokines and is an important factor in the response of the body to attack ... Initially, bNOS may have been present to prepare the cell for stressful conditions but now seems to help shield the bacteria ...
Gap Junction Communication Mediates Transforming Growth Factor-β Activation and Endothelial-Induced Mural Cell Differentiation ...
Figure 2. Cx43+/+ mesenchymal cells undergo endothelial cell-induced mural cell differentiation. A, Cx43+/+ cells exhibited low ... Gap Junction Communication Mediates TGF-β Activation. Because Cx43−/− mesenchymal cells underwent mural cell differentiation in ... mesenchymal cells do not undergo endothelial cell-induced mural cell differentiation. A, Cx43−/− mesenchymal cells not ... mesenchymal cells restores ability to undergo endothelial cell-induced mural cell differentiation. A, reCx43 mesenchymal cells ...
Metabolic shift in density-dependent stem cell differentiation | Cell Communication and Signaling | Full Text
... decreased cellular proliferation and an increase in cell size. In contrast, cells seeded at a lower density of 1,000 cells/cm2 ... Specifically, cell differentiation correlated with an earlier plateauing of exhaustive glycolysis, decreased lactate production ... These results confirm that a distinct metabolic phenotype correlates with cell differentiation of VPCs. ... Here, we examine potential contributions from cell-to-cell signaling or cellular metabolism in the production of VPCs from ESCs ...
Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and...
4H) (12). In no case was this improvement accompanied by the differentiation of donor neurosphere-derived cells into PNs. ... mature electrochemical synaptic communication, is cell-cell coupling via gap junctions that modulate network activity. When we ... A) Communication between grafted mNSCs (GFP+, green arrowhead) and endogenous OC cells tracked by ratiometric [Ca2+]i imaging ... Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and ...
SYMPLASMIC COMMUNICATION/ISOLATION AND PLANT CELL DIFFERENTIATION | Kwartalnik PBK
For better understanding the role of symplasmic isolation/communication in cell differentiation basic information about ... examples it is evident that cell differentiation is connected with the decrease of the symplasmic communication between cells ... It appeared that symplasmic isolation/communication of cells or group of cells (symplasmic domains or symplasmic fields) is ... Genetic control of hair cells differentiation and the role of symplasmic communication in this process were also shown. In the ...
Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions | Nature...
Mammary epithelial cells are epigenetically modified during pregnancy, these changes can influence the pre-disposition to ... Taken together, our findings provide further insight into the cell-autonomous signals in post-pregnancy MECs that underpin the ... Here, the authors examine the epigenetic landscape of mammary epithelial cells pre and post pregnancy and identify changes to ... Pregnancy causes a series of cellular and molecular changes in mammary epithelial cells (MECs) of female adults. In addition, ...
Activation of the PDGFRα-Nrf2 pathway mediates impaired adipocyte differentiation in bone marrow mesenchymal stem cells lacking...
In agreement, Nck1 depletion in 3 T3-L1 cells also attenuates adipocyte differentiation by enhancing PDGFRα activation and ... were used to assess a role for Nrf2 in mediating Nck1 deficiency effect on mesenchymal stem cells adipocyte differentiation. ... To address this point, Nck1-deficient derived bone marrow mesenchymal stem/stromal cells (BM-MSCs) and C3H10T1/2 mesenchymal ... This study demonstrates that Nck1 deficiency in mesenchymal stem cells impairs adipogenesis through activation of the PDGFRα- ...
Auxin - factor in the processes of the communication system over the functional differentiation of a plant cell | Kwartalnik PBK
Auxin signaling processes are the mechanism for the communication of information about resources , conditions and gradients of ... The communication system controlled by auxin at different levels of organization of the plant body is conditioned by the ... years to the study of polar auxin transport in segments tree trunks covering only a single axial zone of the plurality of cells ... polarity of structural cells ( especially in the meristematic tissue ) , which allows transport of the phytohormone bazypetalny ...
Cell Communication in Nervous and Immune System | Eckart D. Gundelfinger | Springer
Results and Problems in Cell Differentiation. Series Volume. 43. Copyright. 2006. Publisher. Springer-Verlag Berlin Heidelberg ... Cell-cell communication by Endocannabinoids during Immune Surveillance of the Central Nervous System ... Cell Communication in Nervous and Immune System. Editors: Gundelfinger, Eckart D., Seidenbecher, Constanze, Schraven, Burkhart ... puts side by side cellular communication devices and signaling mechanisms in the immune and nervous systems and discusses ...
Researchers model the mechanics of cells' long-range communication
Interdisciplinary research at the University of Pennsylvania is showing how cells interact over long distances within fibrous ... Development of matrix material controlling differentiation of stem cells. December 22, 2011 The Tissue Regeneration Materials ... Over-organizing repair cells set the stage for fibrosis. October 20, 2014 The excessive activity of repair cells in the early ... Researchers model the mechanics of cells long-range communication. December 22, 2014 by Evan Lerner, University of ...
Cell lineage conversion in the sea urchin embryo
... the primary mesenchyme cells (PMCs), which produce the larval skeleton, and the secondary mesenchyme cells (SMCs), which ... The mesoderm of the sea urchin embryo conventionally is divided into two populations of cells; ... differentiate into a variety of cell types but do not participate in skeletogenesis. … ... This regulatory system should shed light on the nature of cell-cell interactions that control cell differentiation and on the ...
PDX-1 and cell-cell contact act in synergy to promote delta-cell development in a human pancreatic endocrine precursor cell line
In contrast to expanded populations of primary human islet cells, none of them expr … ... Cell lines from the fetal and adult pancreas that were developed by retroviral transfer of the SV40T and ras(val12) oncogenes ... Cell Communication* * Cell Differentiation* * Cell Line, Transformed * Gene Expression / drug effects * Gene Transfer ... PDX-1 and cell-cell contact act in synergy to promote delta-cell development in a human pancreatic endocrine precursor cell ...
Single cell transplantation reveals interspecific cell communication in Drosophila chimeras | Development
Review - Developing in 3D: the role of CTCF in cell differentiation. In this Review, Rodrigo G. Arzate-Mejía, Félix Recillas- ... Cell-cell communication is not only a common strategy for cell fate specification in vertebrates, but plays important roles in ... Single cell transplantation reveals interspecific cell communication in Drosophila chimeras Message Subject (Your Name) has ... J Cell Sci 2018 131: jcs207779.. H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells. Erika Testa, ...
Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled.
Seeding of distinct intrathymic microenvironments defined by direct thymocyte-stromal cell interactions was correlated with T ... cell development in situ using radiation and nonradiation chimeras of Thy-1.1/1.2 congenic mice. The results identify associ ... Cell Communication*. Cell Differentiation. Clone Cells. Mice. Mice, Inbred C57BL. Radiation Chimera. T-Lymphocytes / cytology* ... All three types of T cell-stromal cell interactions occur after seeding of the intrathymic precursor cell subset and before ...
Cell Differentiation and Communication: Patterns, Problems and Probes, Asilomar, California. * 1975, Feb. 5. Ethical problems ... 4. "Are stable cell determinations or differentiations - those that persist in cell culture-due to nuclear differentiations", ... 7-9. Cell and cell differentiation; Cortical genetics; Pa-cortical genetics, Go Cell Organization, Wittenburg ... Lectures on Cell Patterning, University of Colorado, Boulder, Colorado. * 1976, Oct. 27-28. Stable nuclear differentiations and ...
Session Listing | 29th Fungal Genetics Conference
Cell differentiation and interaction .... Concurrent. Cell Communication. Friday, March 17. Chapel. 3:00 PM-3:20 PM. ... Cell Biology and Development. 191T. Wednesday - Friday,. March 15 - March 17. Fireside Pavillion. Thursday, March 16. 8:30 - 9: ... Cell Biology and Development. 102F. Wednesday - Friday,. March 15 - March 17. Fireside Pavillion. Friday, March 17. 7:30 - 8:30 ... Cell Biology and Development. 113T. Wednesday - Friday,. March 15 - March 17. Fireside Pavillion. Thursday, March 16. 8:30 - 9: ...
Course detail - General Biology and Ecology (185388) - BUT
Cell communication.. Week 8: Cell communication. Cell cycle and differentiation.. Week 9: Basic genetics concepts. Mendel´s ... cell communication, cell cycle and differentiation. Reproduction and heredity, Mendels laws, gene linkage, sex linkage, ... Prokaryotic cell structure.. Week 3: Eukaryotic cell structure. Bioenergetics.. Week 4: Catabolism of carbohydrates, lipids and ... Biology of the cell, prokaryotic and eukaryotic cell structure, energetics, catabolism of carbohydrates, lipids and proteins, ...
E-journals A-Z: Cell Biology | HSLS
Cell death and differentiation. *. v.4(1997)- Access via Nature Publishing Group for Pitt and UPMC users ... Cell communication & adhesion. *. v.9(2002)- Access via Academic Search Premier for Pitt users ... Cell growth & differentiation. *. v.1-13(1990-2002) Access via HighWire for Pitt users ... Cell stem cell. *. v.1(2007)- Access via Elsevier ScienceDirect for Pitt and UPMC users ...
Molecular Control of Proliferation and Differentiation - 1st Edition
Purchase Molecular Control of Proliferation and Differentiation - 1st Edition. Print Book & E-Book. ISBN 9780126129816, ... Cell Communication in Embryological Development: The Role of Distal and Proximal Signals. II. Growth Factors. Biological and ... Aspects of Erythroid Differentiation and Proliferation. The Role of Factors in Differentiation of Non-Erythroid Cells. V. Cell ... Cell Interactions in Blood Cell Development. Factors Affecting the Differentiation of Blood Cells. Factors Controlling the ...
Differential Expression of Adhesion-Related Proteins and MAPK Pathways Lead to Suitable Osteoblast Differentiation of Human...
Stem Cells Dev. 2015 Nov 1;24(21):2577-90. doi: 10.1089/scd.2015.0070. Epub 2015 Aug 27. Research Support, Non-U.S. Govt ... Cellular adhesion enables communication between cells and their environment. Adhesion can be achieved throughout focal ... In vitro experiments of osteogenic differentiation in CD105(-) cells showed superior adhesion efficiency and 2-fold increase of ... adhesions and its components influence osteoblast differentiation of human mesenchymal stem cells (hMSCs). Because cell ...
New peer-reviewed journal Bioelectricity announced, preview issue launching summer 2018 | EurekAlert! Science News
... listen in on and affect communication between cells; and steer growth and differentiation in cultured cells and model organisms ... Phenomena as diverse as local cell-cell communication and patterning of entire organisms have been shown to require bioelectric ... The scientists who pioneered modern studies of bioelectricity--the study of electricity in, around, and among cells--have ... Specific areas of interest include (but are not limited to) bioelectric mechanisms associated with cancer, cell signaling, ...
Cell-cell communication between mouse mammary epithelial cells and 3T3-L1 preadipocytes: Effect on triglyceride accumulation...
Interaction between parenchyma and stroma is essential for organogenesis, morphogenesis, and differentiation. Mammary gland has ... JULIANELLI, Vanina L; GUERRA, Liliana N y CALVO, Juan C. Cell-cell communication between mouse mammary epithelial cells and 3T3 ... The results presented herein contribute to the understanding of cell-cell communication in a model of a normal mammary gland. ... We found a regulation of cell proliferation when NMMG cells are cultured in the presence of conditioned media from Swiss 3T3 or ...
Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration | Nature...
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. ... Nature Communications volume 9, Article number: 4859 (2018) Cite this article * 8791 Accesses ... Sacco, A. & Puri, P. L. Regulation of muscle satellite cell function in tissue homeostasis and aging. Cell Stem Cell 16, 585- ... p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Nat. Med. 20, ...
Extracellular matrix - Wikipedia
... cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM. ... cell migration, cell proliferation, differentiation and cell death (apoptosis). Inhibition of nonmuscle myosin ... Effect on differentiation. ECM elasticity can direct cellular differentiation, the process by which a cell changes from ... Cell adhesion. Many cells bind to components of the extracellular matrix. Cell adhesion can occur in two ways; by focal ...
The Preliminary Experimental Study of Induced Differentiation of Embryonic Stem Cells into Corneal Epithelial Cells | IOVS |...
Keywords: 370 cornea: basic science • 340 cell-cell communication • 372 cornea: epithelium ... Abstract: : Purpose: To study preliminarily induced differentiation of embryonic stem cells into corneal epithelial cells in ... The Preliminary Experimental Study of Induced Differentiation of Embryonic Stem Cells into Corneal Epithelial Cells ... The Preliminary Experimental Study of Induced Differentiation of Embryonic Stem Cells into Corneal Epithelial Cells ...
Matrix metalloproteinases in tumor-host cell communication. Differentiation 2002; 70: 561-73. ... HT1080 cell line was selected for the animal study because of its high-expressing level of cathepsin B ( 19). HT1080 human ... Although cathepsin B is known as a lysosomal enzyme, it also locates on the surface of cancer cells ( 20). It explains how the ... Cell-surface cathepsin B: understanding its functional significance. Curr Top Dev Biol 2003; 54: 313-41. ...
Peptide signaling in plant development. - PubMed - NCBI
Cell Communication/physiology*. *Cell Differentiation/physiology. *DNA-Binding Proteins/genetics. *DNA-Binding Proteins/ ... Cell-to-cell communication is integral to the evolution of multicellularity. In plant development, peptide signals relay ... We discuss how specialization has enabled the CLE peptides to modulate stem cell differentiation in various tissue types, and ... C) CLE41 is secreted by phloem cells and perceived by TDR, which represses differentiation and upregulates the expression of ...
Discoidin domain-containing receptor 2 - Wikipedia
cell adhesion. • positive regulation of osteoblast differentiation. • chondrocyte proliferation. • positive regulation of cell ... RTKs play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation ... Proteins: clusters of differentiation (see also list of human clusters of differentiation) ... Cell Genet. 61 (4): 274-5. doi:10.1159/000133421. PMID 1486804.. *. Abedinia M, Layfield R, Jones SM, Nixon PF, Mattick JS ( ...
Frontiers | Cellular and Molecular Networking Within the Ecosystem of Cancer Cell Communication via Tunneling Nanotubes | Cell...
... the transfer of these varied molecules almost invariably plays a critical role in the communication between cancer cells ... the transfer of these varied molecules almost invariably plays a critical role in the communication between cancer cells ... long distance cell-to-cell transport of cargo, including microRNAs, mitochondria, and a variety of other sub cellular ... long distance cell-to-cell transport of cargo, including microRNAs, mitochondria, and a variety of other sub-cellular ...
Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived...
Monocyte-derived dendritic cells (moDCs) and KG-1 cells are routinely used as mDC models, but a thorough comparison of these ... endocytic and T-cell-activation ability of these cells in support of the proteomic data, and obtained confirmatory evidence for ... and cell-cell interaction and integrity (for example, fascin and actin). We then examined the surface phenotype, cytokine ... We therefore sought to run a comparative study of the proteomes and functional properties of these cells. Despite general ...
Maintaining Connexin43 Gap Junctional Communication in v-Src Cells Does Not Alter Growth Properties Associated with the...
Cell Growth & Differentiation. 1997;8:1015-1027. [PubMed]. 8. Swenson KI, Piwnica-Worms H, McNamee H, Paul DL. Tyrosine ... Characterization of the Cell Clones and Cell Pools. The expression of the Cx43 and v-Src proteins in the cell clones and cell ... cells as compared to communication-deficient tumor cells (6, 11). Up-regulation of gap junctional communication (GJC) in tumor ... J Cell Biol. 2001;154:815-827. [PMC free article] [PubMed]. 6. Loewenstein WR, Rose B. The cell-cell channel in the control of ...
Proliferation and DifferentiationIntercellularCellularRegulationMorphogenesisGenesEpithelialProteinsMetabolismDevelopmentGrowthProteinSignalingDifferentiateNeuronal differentiationPopulationsRegenerative medicineSignalsRegulateJunctionsFateIntracellularMulticellularPrecursor cellRoleMechanismsDendritic cellsEukaryotesMurineEmbryoFunctionalGene ExpressionOrganismsImmune SystemMammalian CellsEndothelial cellsExtracellular matrixHomeostasisDevelopmentalOsteoblasticNeuralTransplantationMiceInteractionLineages
Proliferation and Differentiation4
- Molecular Control of Proliferation and Differentiation documents the proceedings of the 35th symposium of The Society for Developmental Biology entitled 'Molecular Control of Proliferation and Differentiation,' held at Asilomar, Monterey Peninsula, California, June 8-11, 1976. (elsevier.com)
- In plant development, peptide signals relay information coordinating cell proliferation and differentiation. (nih.gov)
- Circulating miRNAs function as 'extracellular communication RNAs' that play an important role in cell proliferation and differentiation. (spandidos-publications.com)
- Planarian cell renewal is achieved as a result of proliferation and differentiation of totipotent undifferentiated cells called neoblasts. (springer.com)
- We investigated whether gap junction channels are formed between endothelial cells and recruited mesenchymal progenitors and whether intercellular communication is necessary for endothelial-induced mural cell differentiation. (ahajournals.org)
- Gap junctions are aggregates of intercellular channels 16 that connect the cytoplasms of adjoining cells and allow the passage of second messengers, ions, and metabolites. (ahajournals.org)
- When we observed that such gap junction formation also seemed to inhibit death of host neurons and suppress such inimical processes as gliosis, we further hypothesized that this mode of direct intercellular communication between exogenous NSCs and host cells might constitute an underappreciated mechanism by which stem cells exert a homeostatic and/or protective effect on endangered host cells. (pnas.org)
- It is also important to notice that plasmodesmata are not passive channels, but critical players in gene regulation, controlling intercellular transport of molecules between particular cells during development . (pbkom.eu)
- Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). (wikipedia.org)
- Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. (frontiersin.org)
- As key mediators of intercellular communication within the tumor ecosystem, TNTs are the central topic of this article. (frontiersin.org)
- ES cells and iPS cells also provide useful models to study connexin expression and gap-junctional intercellular communication (GJIC) during cell differentiation and reprogramming. (frontiersin.org)
- Gap-junctional intercellular communication (GJIC) has long been hypothesized to play a crucial role in the maintenance of homeostasis, morphogenesis, cell differentiation, and growth control in multicellular organisms. (frontiersin.org)
- Discoveries of human genetic disorders due to mutations in connexin genes and experimental data on connexin knockout mice provide direct evidence that gap junctional intercellular communication is essential for tissue functions and organ development and that its dysfunction causes diseases. (frontiersin.org)
- Because of its diverse nature and composition, the ECM can have many functions, such as providing support, segregating tissues, and regulating intercellular communication. (hindawi.com)
- Even though much remains to be learned, we are beginning to appreciate the functions of mammalian exosomes as intercellular signaling and communication devices, and have begun to unravel their complex roles in immune modulation and immune surveillance. (biologists.org)
- Cytokines are key factors regulating immune response and intercellular communication in tumour microenvironment. (mdpi.com)
- Although this review is focused mainly on cancer and particularly melanoma, the discussed techniques are in general applicable to broad research field of biology and medicine, including stem cells, development, aging, immunology and intercellular communication. (mdpi.com)
- Intercellular communication in the eight-cell stage of Xenopus laevis development: a study using dye coupling. (semanticscholar.org)
- Differential protein expression of cell adhesion molecules during density-dependent differentiation identifies molecules related to cellular adhesion and formation of vascularization. (biomedcentral.com)
- Pregnancy causes a series of cellular and molecular changes in mammary epithelial cells (MECs) of female adults. (nature.com)
- Taken together, our findings provide further insight into the cell-autonomous signals in post-pregnancy MECs that underpin the regulation of gene expression, cellular activation, and resistance to malignant development. (nature.com)
- This collection of reviews, contributed by internationally recognized immunologists and molecular and cellular neurobiologists, puts side by side cellular communication devices and signaling mechanisms in the immune and nervous systems and discusses mechanisms of interaction between the two systems, the significance of which has only recently been fully appreciated. (springer.com)
- Cellular adhesion enables communication between cells and their environment. (nih.gov)
- In tissues such as the skin, small intestine, and kidney, declines in α-Klotho have been shown to promote cellular senescence 24 and stem cell dysfunction 17 . (nature.com)
- Identification of key cellular cargo and their varied modes of transport are important considerations in understanding the basic mechanisms of cancer cell growth. (frontiersin.org)
- Tunneling nanotubes (TNTs)-narrow actin-based cytoplasmic extensions-are unique structures that facilitate direct, long distance cell-to-cell transport of cargo, including microRNAs, mitochondria, and a variety of other sub cellular components. (frontiersin.org)
- Cellular communication is a critical component of heterotypic and homotypic interactions in the complex, ever-changing tumor microenvironment. (frontiersin.org)
- Each cell contains only one nucleus, whereas other types of organelles are present in multiple copies in the cellular contents, or cytoplasm . (britannica.com)
- The current challenge in cell biology is to decipher the spatial-temporal interactions of these highly complex intracellular signaling pathways in mediating the various cellular responses. (mit.edu)
- Signals can be transmitted to neighboring cells where they can activate or suppress a given developmental fate through inter-cellular signal transduction. (osu.edu)
- Cellular communication is essential to the proper manifestation of cell movements, growth, and differentiation during the development of multi-cellular organisms. (brown.edu)
- It is also involved in the phenomenon of homeostasis, in cellular signaling and in cell communication, proliferation, differentiation and survival [ 3 , 4 ]. (mdpi.com)
- Specifically, he is studying two cellular communication pathways called Notch and fibroblast growth factor (FGF), and their role in breast cancer progression. (lunenfeld.ca)
- miRNAs may help explain certain connections in the cell, and facilitate cross-talk between two cellular communication pathways inside a cell. (lunenfeld.ca)
- Cellular renewal on the basis of stem (basal) cell proliferation is a hallmark of most epithelial tissues. (jneurosci.org)
- 2016 ). These cells undergo a special differentiation program that culminates in enucleation and clearing of most of the cellular content to reduce flow resistance yet remain alive (De Rybel et al. (springer.com)
- 2014 ). SEs undergo a specialized differentiation process, during which the cellular components are partially degraded and rearranged within a stretch of approximately 10 cells before enucleation (Furuta et al. (springer.com)
- hormonal communication and cellular stress responses. (biomedcentral.com)
- MiRNAs were first identified in Caenorhabditis elegans in the early 1990s ( 8 ), but have since been reported in a wide variety of organisms ranging from single-cell algae to humans, suggesting that miRNA-mediated biological function is an ancient and critical cellular regulatory system ( 9 , 10 ). (spandidos-publications.com)
- This confirms the role of PD in the regulation of cells differentiation. (pbkom.eu)
- Cell regulation. (pitt.edu)
- We have demonstrated a regulation of triglyceride accumulation by protein factors synthesized by normal mouse mammary gland epithelial cells (NMMG), acting on a cell line, 3T3-L1, long used as a model for adipogenesis. (scielo.org.ar)
- We found a regulation of cell proliferation when NMMG cells are cultured in the presence of conditioned media from Swiss 3T3 or 3T3-L1 cells. (scielo.org.ar)
- These molecules are involved in the regulation of cell growth, differentiation, and metabolism. (wikipedia.org)
- The transport of cargo via TNTs occurs between malignant and stromal cells and can lead to changes in gene regulation that propagate the cancer phenotype. (frontiersin.org)
- Up-regulation of gap junctional communication (GJC) in tumor cells by the expression of exogenous connexins has been shown to reduce the growth rates of the tumor cells, whereas the down-regulation of GJC in normal cells following treatment with tumor promoting agents or growth factors or by the induced expression of oncogenes has been associated with an increase in the rates of cell proliferation. (pubmedcentralcanada.ca)
- Therefore, in addition to transmitting mechanical forces across otherwise vulnerable membranes, they are involved in cell signaling and the regulation of cell cycle, shape, and motility. (hindawi.com)
- Moreover, previous studies have shown that altered expression levels of miRNAs can contribute to pathological conditions, such as cancer, due to the loss of cell cycle regulation. (springer.com)
- However, the precise mechanism underlying miRNA-mediated regulation of cell cycle in stem cells is still incompletely understood. (springer.com)
- Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation," Cell Stem Cell , vol. 2, no. 2, pp. 160-169, 2008. (hindawi.com)
- Researchers suspect miRNAs are involved in the regulation of immunity, the development and differentiation of immune cells, antibody production and the release of chemicals involved in the inflammatory response. (lunenfeld.ca)
- Transcriptional regulation factors interacting and cooperating at promoter regions determine the fate of cells and their function. (biomedcentral.com)
- The exact interactions between endothelial and mesenchymal cells during vessel assembly that lead to TGF-β activation and mural cell differentiation are not well defined but are presumably complex given the number of genes implicated by mutation studies to regulate these processes during vascular development. (ahajournals.org)
- The growth of cells in the body is a closely controlled function, which, together with limited and regulated expression of various genes, gives rise to the many different tissues that constitute the whole organism. (britannica.com)
- This analysis identified multiple genes as differentially expressed in pancreatic cancer cells and in fibroblasts as a consequence of their mutual interactions, including those that encode for proteins associated with tumor invasion, metastasis, and angiogenesis. (aacrjournals.org)
- Among the genes identified, the cyclooxygenase-2 ( COX-2 ) /PTGS2 gene was of particular interest because COX-2 expression was markedly augmented in both cell types (cancer cells and fibroblasts) in response to coculture. (aacrjournals.org)
- Gene enrichment analyses show depletion of expressed genes in categories related to development, cell differentiation, and cell-cell communication. (pnas.org)
- Esto produce una acumulación de esta proteína en el citoplasma celular y permite su entrada al núcleo, donde ejerce su acción al unirse a una serie de moléculas y factores de transcripción, permitiendo de este modo que se expresen los genes diana, entre los que se encuentran los de las hormonas incretinas. (isciii.es)
- Epigenetics is what determines the differences between the cells in your body - when cells commit to different fates during development, what they're really doing is reprogramming their epigenetics, turning massive sets of genes on or off through chemical modifications of DNA or associated proteins. (biology-online.org)
- The role of genes in the determination and differentiation of eukaryotes. (temple.edu)
- The discovery of developmental genes that encode hair cell differentiation facilitates the design of interventions to promote generation of new hair cells in cochleae with hair cell loss. (jneurosci.org)
- Although a few genes have been demonstrated to function in phloem development, detailed analyses and a comprehensive understanding of sieve element development (i.e. how often the stem cells divide, how frequently enucleation takes place, and how SE development is coordinated between cell division and differentiation on a molecular level) are still lacking. (springer.com)
- The Osteo-Promoter Database (OPD) is a collection of genes and promoters expressed in skeletal cells. (biomedcentral.com)
- Genes in eukaryotic cells are regulated in "active regions," in which chromatin structure is "open" and accessible to DNA-binding proteins and "silent regions" where "packed" chromatin renders the DNA inaccessible. (biomedcentral.com)
- He outfitted the sending cell with promoters and genes to allow the controlled expression of a chemical called V. fischeri autoinducer. (sciencemag.org)
- Upon detecting this chemical, the receiving cell would express specific genes. (sciencemag.org)
- or how the microenvironment can regulate cell function by changing which genes can be expressed. (ualberta.ca)
- After a significant delay, this recognition stage is followed by concomitant interactions of T cells with I-A+ epithelial cells in the cortex and bone marrow-derived I-A+ dendritic cells in the medulla. (biomedsearch.com)
- The seeding kinetics imply that recognition of cortical epithelial cells by thymocytes in situ represents a relatively late stage of cortical T cell development, whereas thymocyte-dendritic cell interactions denote a very early stage of T cell development in the medulla. (biomedsearch.com)
- In this paper, we demonstrate that this inhibitory effect seems to be shared by other cells of epithelial origin but not by other cell types. (scielo.org.ar)
- Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest. (wikipedia.org)
- Murine embryonic stem cells were co-cultured with Rabbit limbal corneal epithelial cells in Transwell system to induce differentiation. (arvojournals.org)
- Embryonic stem cells can differentiated into epithelial-like cells, The cells formed network and were confluent into film gradually after co-cultured with rabbit limbal corneal epithelial cells 24-96 hours. (arvojournals.org)
- The induced cells expressed the corneal epithelial cell specific marker cytokeratin3/cytokeratin12. (arvojournals.org)
- Rabbit limbal corneal epithelial cells can induce murine embryonic stem cells to differentiate into corneal epithelial cells. (arvojournals.org)
- Demonstrating how the Hippo-Yap signaling pathway, interacts with high-risk HPV oncoproteins to regulate cervical epithelial cell transformation and cervical cancer cell proliferation. (massgeneral.org)
- Our recent preliminary studies showed that YAP, the major effector of the Hippo tumor suppressive pathway, interacts with high-risk HPV oncoproteins to regulate cervical epithelial cell transformation and cervical cancer cell proliferation. (massgeneral.org)
- We demonstrate that in vivo inoculation of adenovirus with the Math1 gene insert into the endolymph of the mature guinea pig cochlea results in Math1 overexpression in nonsensory cochlear cells, as evident from the presence of Math1 protein in supporting cells of the organ of Corti and in adjacent nonsensory epithelial cells. (jneurosci.org)
- The auditory sensory epithelium in the inner ear, the organ of Corti, is an epithelial mosaic made of hair cells and supporting cells. (jneurosci.org)
- Overexpression of Math1 in cultures of immature rat cochleae results in the production of ectopic hair cells derived from nonsensory epithelial precursors ( Zheng and Gao, 2000 ). (jneurosci.org)
- It occurs as a proteoglycan (PG) in which two or three HS chains are attached in close proximity to cell surface or ECM proteins. (wikipedia.org)
- Despite general similarities between mDCs and the model systems, moDCs and KG-1 cells, our findings identified some significant differences in the proteomes of these cells, and the findings were confirmed by ELISA detection of a selection of proteins. (biomedcentral.com)
- This was particularly noticeable with proteins involved in cell growth and maintenance (for example, fibrinogen γ chain (FGG) and ubiquinol cytochrome c) and cell-cell interaction and integrity (for example, fascin and actin). (biomedcentral.com)
- Students will have insight into how cells produce and export proteins, and how material is endocytosed. (manchester.ac.uk)
- and morphogens, proteins involved in the growth and differentiation of the cells that line the gut. (eurekalert.org)
- In many cases mammalian cells are the only option to produce recombinant proteins with correct post-translational modifications, e.g. glycosylation, which are required for proper function of the therapeutic protein. (news-medical.net)
- In this report, we identify exosome-based secretion as a general mechanism for protein secretion by Leishmania , and show that exosomes are involved in the delivery of proteins into host target cells. (biologists.org)
- In eukaryotes, the cell division cycle includes four discrete phases: Gap 1 (G1), Synthesis (S), Gap 2 (G2) and Mitosis (M). During the G1 phase, which is known as the first interphase, the cell synthesizes proteins that are needed for DNA replication and continuous growth. (springer.com)
- They contain functional proteins and genetic materials and serve as a vehicle for communication between cells. (nanowerk.com)
- In combination with synthetic nanoparticles that my laboratory is developing, we may ultimately be able to use these identified miRNAs or proteins to make synthetic exosomes, thereby avoiding the need to use any kind of neural progenitor cell line to induce neuron growth," said the paper's senior and corresponding author Qiaobing Xu, assistant professor of biomedical engineering at Tufts School of Engineering. (nanowerk.com)
- Cell metabolism. (pitt.edu)
- Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. (springer.com)
- Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton through integrin-mediated signaling via cell-matrix interaction. (hindawi.com)
- 5 Fatty Acid Cyclooxygenase Metabolism of Arachidonic Acid in Human Tumor Cells. (weltbild.de)
- proliferating or activated endothelial cells also express Cx43, 27,28 as do endothelial cells during vascular development. (ahajournals.org)
- In presented article information about the role of symplasmic isolation during the differentiation of trichoblast and atrichoblast cells, changes within the embryo sac in connection with the fertilization, double fertilization, zygote and seed development were described. (pbkom.eu)
- In the case of embryo sac development of Torenia fournieri results from experiments where symplasmic communication was investigated with the use of fluorochrome of low molecular weight (LYCH) and dextrans (3, 10 and 40 kDa) were described [12, (pbkom.eu)
- The importance of symplasmic communication during zygotic and somatic embryogenesis were briefly described on the example of Arabidopsis embryo development. (pbkom.eu)
- From all described examples it is evident that cell differentiation is connected with the decrease of the symplasmic communication between cells which undergo different fate during the development. (pbkom.eu)
- Existing experimental evidence showed that mechanical forces were at play in the changes in both fibrosis and cancer and that these forces were important to their development and progression but could not explain the long-ranging changes cells were able to produce to change their environments. (phys.org)
- This system provides a powerful model for studying human islet cell development and, particularly, the role of cell-cell contact in the differentiation process. (nih.gov)
- Cell-cell communication is not only a common strategy for cell fate specification in vertebrates, but plays important roles in invertebrate development as well. (biologists.org)
- Following interspecific transplantation, the development of single ectodermal cells was traced in order to test their abilities to proliferate and differentiate in a heterologous environment. (biologists.org)
- Development and homeostasis depend crucially on the maintenance of cell identity, and in gamete-producing tissues the somatic/germline distinction is paramount. (biologists.org)
- A recent paper in Development explores how cell identity is secured in the Drosophila ovary by studying the function of the conserved tumour suppressor L(3)mbt. (biologists.org)
- Seeding of distinct intrathymic microenvironments defined by direct thymocyte-stromal cell interactions was correlated with T cell development in situ using radiation and nonradiation chimeras of Thy-1.1/1.2 congenic mice. (biomedsearch.com)
- All three types of T cell-stromal cell interactions occur after seeding of the intrathymic precursor cell subset and before development of mature medullary-type T cells. (biomedsearch.com)
- Part I presents a paper on cell communication in embryological development. (elsevier.com)
- Part IV focuses on cell interactions in blood cell development. (elsevier.com)
- Hyaluronic acid acts as an environmental cue that regulates cell behavior during embryonic development, healing processes, inflammation , and tumor development. (wikipedia.org)
- A) Scheme of Arabidopsis stomatal development illustrated in isolated cells, and in the context of the developing leaf below. (nih.gov)
- The potential to generate basically any differentiated cell types from these cells offers the possibility to establish new models of mammalian development and to create new sources of cells for regenerative medicine. (frontiersin.org)
- Such restriction of GJIC and the segregation of cells into communication compartment domains are almost always associated with embryogenesis and development. (frontiersin.org)
- This statement of Furton and Matthews-Roth (quoting Pedersen et al) is essentially stating that past a certain point in early human embryonic development, the cells of the developing embryo are permanently "fated" to be only involved in the development of the placental tissues or of the embryo proper and the fetal membranes. (lifeissues.net)
- Normal brain development is the result of an undisturbed harmonious interaction among cells, and between cells and hormones. (fluoridealert.org)
- During development, this evolutionary conserved pathway functions in various cell types and stages. (news-medical.net)
- In particular, our previous study unveiled the role of GPR30 (now call GPER1), the membrane G protein-coupled estrogen receptor, in mediating the estrogen action during ovarian cell-cell communication and follicle development. (massgeneral.org)
- We report an investigation of dye coupling in the eight-cell stage of Xenopus laevis development. (semanticscholar.org)
- There are two broad types of stem cells including embryonic stem cells (ESCs), which are solely present at the earliest stages of development, and somatic (or adult) stem cells, which appear during fetal development and remain throughout life. (springer.com)
- The development of a controlled differentiation scheme for ES cells has been hindered by the lack of a reliable method to produce uniform aggregate sizes. (rsc.org)
- In 2015, he received a Faculty Early Career Development (CAREER) award from the National Science Foundation (NSF), funding research into a new way to deliver protein-based cancer-fighting drugs and other therapeutics directly into cells. (nanowerk.com)
- Math1 , the basic helix-loop-helix transcription factor homolog of the Drosophila atonal gene, is a positive regulator of hair cell differentiation during cochlear development. (jneurosci.org)
- Thus, the pore structure leads to selective transport, which helps drive cell differentiation during development. (news-medical.net)
- In addition, understanding the interplay between the PLETHORA (PLT) gradient, which is known to govern the root zonation, and phloem development within the root meristem could shed light on the rapidity of SE differentiation and its importance to the meristem. (springer.com)
- Weiss began his work in amorphous computing by building a model to elucidate the mechanisms by which nature achieves cell differentiation during the development of the embryo. (sciencemag.org)
- Bidirectional communication between cells and their microenvironment is a hallmark of both cancer progression and embryological development. (ualberta.ca)
- Ultimately, these studies will lead to the development of methods to maintain normal stem cell pluripotency and to inhibit cancer cell plasticity and metastasis. (ualberta.ca)
- 2 During branching and remodeling of the initial plexus that leads to a well-defined vascular network, 3 endothelial tubes acquire a surrounding vessel wall of mural cells (pericytes or smooth muscle cells) via the secretion of platelet-derived growth factor-B that acts as a chemoattractant and mitogen for mural cell precursors. (ahajournals.org)
- 4-6 On contact with endothelial cells, the recruited progenitors are induced toward a mural cell fate, 7 in a process mediated by the activation of transforming growth factor-beta (TGF-β). (ahajournals.org)
- Indeed, we demonstrated that Nck1 deficiency in mice is associated with reduced adiposity and impaired adipocyte differentiation mediated by platelet-derived growth factor receptor α (PDGFRα)-dependent remodeling of preadipocytes [ 4 ]. (biomedcentral.com)
- Cell growth & differentiation. (pitt.edu)
- and steer growth and differentiation in cultured cells and model organisms. (eurekalert.org)
- Loss of connexin expression and/or gap junctional communication (GJC) has been correlated with increased rates of cell growth in tumor cells compared to their normal communication-competent counterparts. (pubmedcentralcanada.ca)
- Conversely, reduced rates of cell growth have been observed in tumor cells that are induced to express exogenous connexins and re-establish GJC. (pubmedcentralcanada.ca)
- however, it is not known whether their ability to maintain GJC prevents the loss of growth restraints that confine "normal" cells, such as the inability to grow in an anchorage-independent manner or to form foci. (pubmedcentralcanada.ca)
- In these studies, we have examined some of the growth properties of cells with Cx43 gap junctions that remain communication-competent in the presence of the co-expressed v-Src oncoprotein. (pubmedcentralcanada.ca)
- Re-expression of the rat wild type Cx43 protein (wt Cx43) in these fibroblasts made them communication-competent and significantly reduced their rates of growth in culture. (pubmedcentralcanada.ca)
- Since the cells that express this Cx43 mutant maintain GJC in the presence of the co-expressed v-Src kinase, the question has been raised of whether the disruption of normal growth control that is characteristic of v-Src transformed cells is also observed in the cells that retain the ability to communicate through Cx43 gap junctions in the presence of v-Src. (pubmedcentralcanada.ca)
- One major organelle , the nucleus , contains the genetic information necessary for cell growth and reproduction . (britannica.com)
- Hormones play an important role in cell migration and differentiation, neuron-to-neuron communication and growth. (fluoridealert.org)
- Mitochondria also play important roles in communication within and between cells and important aspects of cell differentiation and growth. (redorbit.com)
- In earlier studies, involvement of the niche constituents- fibronectin (FN), laminin (La) and fibrin (Fib)- for NPC growth and differentiation was established. (deepdyve.com)
- For example, Dr. Andreas Evangelou, a post-doctoral fellow in Dr. Andrulis' lab, is studying the mechanisms associated with the growth and metastasis of breast cancer cells. (lunenfeld.ca)
- These pathways control intracellular communication mechanisms that help regulate cell growth and differentiation. (lunenfeld.ca)
- Advanced live-imaging techniques which enable prolonged time-lapse captures of root tip growth as well as single-cell transcriptomic analysis of the 20-25 cells in the SE file could help resolve these questions. (springer.com)
- T issue growth and differentiation at the air-liquid-interface. (gbo.com)
- The absence of mitosis within the planarian pharynx raises the question as to how cell renewal and growth occur within this organ. (springer.com)
- Protein expression analysis of induced vascular progenitor cells (VPCs) derived from embryonic stem cells (ESCs) comparing seeding densities of 1,000 vs 10,000 cells/cm 2 . (biomedcentral.com)
- We recently demonstrated that lack of the adaptor protein Nck1 in mice is associated with reduced adiposity and impaired adipocyte differentiation. (biomedcentral.com)
- Promotion of cell-cell contact by aggregation of TRM-6/PDX-1 into islet-like clusters produced a further 10- to 100-fold increase in somatostatin mRNA, to a level similar to that of freshly isolated islets, which resulted in production of somatostatin protein. (nih.gov)
- Discoidin domain-containing receptor 2 , also known as CD167b ( cluster of differentiation 167b), is a protein that in humans is encoded by the DDR2 gene . (wikipedia.org)
- In cells that express the v-Src protein kinase, wt Cx43 is phosphorylated on tyrosine residues and GJC is dramatically disrupted ( 2 , 5 , 8 , 12 ). (pubmedcentralcanada.ca)
- This protein is active in cells that make up a part of the hair follicle known as the matrix. (medlineplus.gov)
- The overactive protein triggers matrix cells to divide too quickly and in an uncontrolled way, leading to the formation of a pilomatricoma. (medlineplus.gov)
- Compared with non-sorted cells, the sorted cells cultured in scaffolds underwent more chondrogenic differentiation, as evidenced by higher expression of type II collagen and Sox9 at the protein and mRNA levels. (biomedsearch.com)
- Protein phosphorylation is an essential post-translational modification that modulates cell-cell communication. (springer.com)
- In this study, the correlation between Cx43 and IDO were determined by the treatment of resveratrol and S.C. Our data showed an increase in Cx43 while IDO protein and IDO-mediated inhibited effects on T cell decreased after tumor cells are given with resveratrol and S.C. treatments. (medsci.org)
- Notch is a single transmembrane protein located on the cell surface with transmembrane ligands. (news-medical.net)
- These results led us to hypothesize that Leishmania use an exosome-based mechanism to actively regulate protein release from the cell. (biologists.org)
- The Phase I/II clinical trial focuses on a protein called CCR5 that plays a key role in enabling HIV to infect cells. (ca.gov)
- For example, gamma secretase is critical for the processing of a protein called Notch, which controls cell differentiation and communication. (xconomy.com)
- In Alzheimer's disease, a toxic type of protein accumulates in brain neurons and leads to mitochondrial rupture and cell death. (redorbit.com)
- When a cell enters the G1 phase, a protein called cyclin D increases in response to mitogenic stimuli. (springer.com)
- At the same time, the studies on synchronization of protein synthesis rhythm in mammalian cell cultures demonstrated that noradrenaline and serotonin have conserved their ancient function of cell-cell cooperation in mammals, which is manifested as coordinated social behavior of cells in population in the case of bacteria and multicellular organisms. (deepdyve.com)
- After 20 days of induction of differentiation, we analyzed the stem cell populations using gene and protein expression assays as well as biochemical functions. (rsc.org)
- We recently reported protein kinase A (PKA) to be part of a macromolecular signaling complex with ezrin and gap junction protein connexin 43 (Cx43) that provides cAMP-mediated control of gap junction communication. (biochemj.org)
- In agreement, Nck1 depletion in 3 T3-L1 cells also attenuates adipocyte differentiation by enhancing PDGFRα activation and signaling. (biomedcentral.com)
- Our study highlights Nrf2 as an important player in mediating PDGFRα signaling that limits the generation of fat cells upon Nck1 deficiency. (biomedcentral.com)
- It is also involved in cell signaling as part of the Wnt signaling pathway . (medlineplus.gov)
- 2019 ) Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication. (neurotree.org)
- Brodsky, V. 2009-04-06 00:00:00 Comparison of current data on direct cell-cell communications in mammals, protists, and bacteria suggests that the emergence of the signaling systems of self-organization underlay the emergence of multicellular organisms. (deepdyve.com)
- The number of neural stem cells (NSCs), for example, that differentiate into mature well-integrated neurons, and the lengthy time this process requires, are usually insufficient to account for the improvement. (pnas.org)
- the primary mesenchyme cells (PMCs), which produce the larval skeleton, and the secondary mesenchyme cells (SMCs), which differentiate into a variety of cell types but do not participate in skeletogenesis. (nih.gov)
- Pluripotent stem cells, i.e., embryonic stem (ES) and induced pluripotent stem (iPS) cells, can indefinitely proliferate without commitment and differentiate into all cell lineages. (frontiersin.org)
- The outer blastomeres ultimately differentiate into the trophoblast, whereas the inner blastomeres form the inner cell mass, from which the body of the embryo arises. (lifeissues.net)
- ESCs are pluripotent and therefore have the capacity to differentiate into all the possible cell types of the three germ layers. (springer.com)
- Transplanted stem cells can differentiate into just about any other kind of cell, including neurons to potentially reconnect a severed spinal cord and repair paralysis. (nanowerk.com)
- A variety of agents have been shown to induce transplanted stem cells to differentiate into neurons. (nanowerk.com)
- The researchers hypothesize that the exosomes caused the hMSCs to differentiate by delivering miRNA into the stem cells. (nanowerk.com)
- The past decade has seen an explosion of research on cells with the capacity to differentiate in response to specific microenvironmental cues. (ualberta.ca)
- We report that, in organotypic slice cultures analyzed by ratiometric time-lapse calcium imaging, current-clamp recordings, and dye-coupling methods, an early and essential way in which grafted murine or human NSCs integrate functionally into host neural circuitry and affect host cells is via gap-junctional coupling, even before electrophysiologically mature neuronal differentiation. (pnas.org)
- The biomedical engineers also showed that the exosomes contain miRNAs--tiny pieces of RNA that regulate cell behavior and are known to play a role in neuronal differentiation. (nanowerk.com)
- In contrast to expanded populations of primary human islet cells, none of them express the homeodomain transcription factor PDX-1. (nih.gov)
- Notch pathway maintains stem cell populations and regulates binary cell fate choice. (news-medical.net)
- Communication received through cell contact is critical for the differentiation of specialized effector cell populations during the immune response. (sciencemag.org)
- Recent studies have found that cancers may similarly develop from stem cell populations, and that these rarely occurring cells care likely responsible for tumour formation, drug resistance and metastasis. (ualberta.ca)
- For the first time ever at BIO International , the largest annual biotechnology conference in North America, stem cells and regenerative medicine were featured in an all-day forum. (ca.gov)
- control of epigenetics is also how you reprogram cells to different functions, which is an important component of regenerative medicine. (biology-online.org)
- Nanowerk News ) Regenerative medicine using stem cells is an increasingly promising approach to treat many types of injury. (nanowerk.com)
- By studying Stem Cells and Regenerative Medicines MSc at Aston, you'll discover more about how the use of stem cells in regenerative medicine and drug discovery is one of the most crucial areas of research today. (aston.ac.uk)
- During the differentiation of trichoblasts and atrichoblasts the importance of signals movement between cells through plasmodesmata and changes in symplasmic communication were described on the example of Arabidopsis root [13, (pbkom.eu)
- Thus, we demonstrate here that signals induced by cell-cell contact act in synergy with PDX-1 to up-regulate the endogenous somatostatin promoter in an immortalized cell line from human fetal islets. (nih.gov)
- detection of extracellular signals from other cells 5.communication via diffusable chemical signals from cells at a distance. (wikibooks.org)
- Signals are transduced by the cell-surface receptor Notch. (wikipedia.org)
- T lymphocytes, in turn, provide key differentiation signals to B lymphocytes. (sciencemag.org)
- Emerging evidence suggests that miRNAs regulate critical pathways involved in stem cell function. (springer.com)
- 3. the processes which regulate and integrate cell function. (studiesabroad.com)
- The unifying goal of our research program is to determine what types of microenvironments regulate normal and cancer stem cell plasticity and function, and to elucidate the mechanisms by which such microenvironments elicit their effects. (ualberta.ca)
- Stable reexpression of Cx43 in Cx43 −/− cells (reCx43) restored their ability to form gap junctions with endothelial cells and undergo endothelial-induced mural cell differentiation. (ahajournals.org)
- 18,19 The presence of gap junctions has been documented among and between vascular cells. (ahajournals.org)
- 29 Mural cell gap junctions are predominantly composed of Cx43 26 but may also contain Cx40, 24,30,31 Cx37, or Cx45. (ahajournals.org)
- The gap junctions, which are established rapidly, permit exogenous NSCs to influence directly host network activity, including synchronized calcium transients with host cells in fluctuating networks. (pnas.org)
- To determine whether gap junctions between NSCs and host cells may also mediate neuroprotection in vivo, we examined NSC transplantation in two murine models characterized by degeneration of the same cell type (Purkinje neurons) from different etiologies, namely, the nervous and SCA1 mutants. (pnas.org)
- In both, gap junctions (containing connexin 43) formed between NSCs and host cells at risk, and were associated with rescue of neurons and behavior (when implantation was performed before overt neuron loss). (pnas.org)
- Here we report that an early and essential step in the functional integration of grafted murine and human NSCs into host neural circuitry, even before (and perhaps establishing a template for) mature electrochemical synaptic communication, is cell-cell coupling via gap junctions that modulate network activity. (pnas.org)
- Cells that express a Cx43 mutant with phenylalanine mutations at these tyrosine sites form functional gap junctions that, unlike junctions formed by wild type Cx43, remain functional in cells that co-express v-Src. (pubmedcentralcanada.ca)
- epithelia and cell junctions. (manchester.ac.uk)
- We report here on experiments testing the compatibility of mechanisms specifying cell fate among six different Drosophila species. (biologists.org)
- CARLSON (1994): According to the inside-outside hypothesis, the position of a blastomere determines its developmental fate (i.e., whether it will become part of the inner cell mass or trophoblast). (lifeissues.net)
- Cell size is often overlooked in the drive to define molecular mechanisms, but as a basic physical property it is an integrator of the cell's metabolic rate and indicator of cell fate. (mit.edu)
- Intracellular dye injection and dual whole-cell voltage clamp revealed that endothelial cells formed gap junction channels with Cx43 +/+ but not Cx43 −/− progenitors. (ahajournals.org)
- When a Notch transmembrane receptor establishes contact with a cell, it interacts extracellularly with the Notch transmembrane ligand which initiates proteolytic cleavage of the receptor and consequently the Notch intracellular domain (Notch ICD or NICD) of the receptor is released. (news-medical.net)
- Some single-celled organisms adopt multicellular biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS). (wikipedia.org)
- These cells cooperate with other specialized cells and become the building blocks of large multicellular organisms, such as humans and other animals . (britannica.com)
- In a multicellular organism , cells become specialized to perform different functions through the process of differentiation. (britannica.com)
- It is important for cell-cell communication and neuronal precursor cell differentiation. (osu.edu)
- Although TGF-β activation is not completely understood, 8,9 it is clear that activated TGF-β plays a critical role in the induction of mural cell differentiation. (ahajournals.org)
- For better understanding the role of symplasmic isolation/communication in cell differentiation basic information about plasmodesmata, symplasm and symplasmic transport are also described in presented paper. (pbkom.eu)
- Genetic control of hair cells differentiation and the role of symplasmic communication in this process were also shown. (pbkom.eu)
- The relative positioning of these cell-cell recognition stages during the course of T cell maturation pertains to a putative role of these microenvironments in selection and tolerization of the T cell repertoire. (biomedsearch.com)
- Genetic inhibition of α-Klotho in vivo disrupted muscle progenitor cell (MPC) lineage progression and impaired myofiber regeneration, revealing a critical role for α-Klotho in the regenerative cascade. (nature.com)
- RTKs play a key role in the communication of cells with their microenvironment. (wikipedia.org)
- Dendritic cells (DCs) are specialized antigen presenting cells that play a pivotal role in bridging innate and adaptive immune responses. (biomedcentral.com)
- In zebrafish, rabconnectin-3a is involved in neural crest migration by playing a role in endosomal maturation in neural crest cells. (wikipedia.org)
- Mayer's research on inflammatory bowel disease pathogenesis was among the first to demonstrate the role played by T-regulatory cells in setting the stage for chronic mucosal inflammation (IBD). (wikipedia.org)
- He was the first to describe the role of T cells in immunoglobulin class switching and to identify a novel T-cell-derived cytokine (446-BCDF) that stimulates antibody secretion by human B cells. (wikipedia.org)
- It also plays the role of mediator during short-range cell-cell communication. (news-medical.net)
- Narrowly regulated cell-cell communication plays critical role in the follicle cell proliferation, differentiation, steroidogenesis, oocyte maturation and ovulation. (massgeneral.org)
- The scientists think that the fundamental role of neuroglobin found in neurons is to prevent accidental cell death from occurring due to stress associated with normal cell functioning. (redorbit.com)
- Here we show that a member of interferon regulatory factor (IRF) family of transcription factors, IRF8, has a critical role in silencing T\(_H\)17-cell differentiation. (harvard.edu)
- In this review, we discuss current knowledge of miRNAs regulatory role in cell cycle progression of stem cells. (springer.com)
- Embryonic stem (ES) cells form spontaneous aggregates during differentiation, and cell-cell communication in the aggregates plays an important role in differentiation. (rsc.org)
- Clones comprised cells of epidermal and/or neural histotypes, indicating that mechanisms mediating the epidermal/neural dichotomy in the ectoderm are conserved between the species. (biologists.org)
- Phenomena as diverse as local cell-cell communication and patterning of entire organisms have been shown to require bioelectric mechanisms working synergistically with molecular mechanisms. (eurekalert.org)
- However, the exact mechanisms by which neuroglobin protects cells from dying a natural death has, until now, remained unclear. (redorbit.com)
- Although RORγt is necessary for the generation of T\(_H\)17 cells, the molecular mechanisms underlying the functional diversity of T\(_H\)17 cells are not fully understood. (harvard.edu)
- Two advances make this new branch of biological engineering possible: a better understanding of biochemical mechanisms in cells and the ability to make DNA sequences from scratch in the lab. (sciencemag.org)
- Monocyte-derived dendritic cells (moDCs) and KG-1 cells are routinely used as mDC models, but a thorough comparison of these cells has not yet been carried out, particularly in relation to their proteomes. (biomedcentral.com)
- Dendritic cells (DCs) are highly specialized antigen presenting cells that originate from bone marrow progenitor cells. (biomedcentral.com)
- Cell transplantation and cell marking experiments have been carried out to determine the number of SMCs that convert when intermediate numbers of PMCs are present in the embryo. (nih.gov)
- The claim that certain cells in the early developing embryo are "fated" or irreversibly determined , is questioned by some human embryologists, and put in doubt by recent studies using human embryonic, fetal and adult stem cells. (lifeissues.net)
- A colony of cells in an embryo self-organizes to form an organism, facilitated by the information-dense code -- the common genetic program -- embedded in each cell. (sciencemag.org)
- Reestablishment of functional networks in the central nervous system (CNS) has been proffered as one of the goals of stem cell-mediated therapeutics. (pnas.org)
- We therefore sought to run a comparative study of the proteomes and functional properties of these cells. (biomedcentral.com)
- We then examined the surface phenotype, cytokine profile, endocytic and T-cell-activation ability of these cells in support of the proteomic data, and obtained confirmatory evidence for differences in the maturation status and functional attributes between mDCs and the two DC models. (biomedcentral.com)
- When that factor was expressed in the cell lines by retroviral-mediated gene transfer, one of the cell lines, TRM-6, derived from human fetal islets, exhibited a 10- to 100-fold increase in somatostatin gene expression. (nih.gov)
- Global gene expression profiling was performed using oligonucleotide microarrays to determine changes in the gene expression of pancreatic cancer cells (CFPAC1) and stromal fibroblasts induced by coculture. (aacrjournals.org)
- Notch signalling is involved in the cell-cell communication process via influencing the patterns of gene expression and differentiation. (news-medical.net)
- The unique feature of plant organisms is the presence of plasmodesmata (PD) between neigh- boring cells. (pbkom.eu)
- The production of new cells is vital to the survival of species and there will be an introduction to basic genetic concepts to explain how organisms can pass on their traits which convey selective advantages for survival in a fiercely competitive world. (studiesabroad.com)
- In mammalian cells that express v-Src, connexin43 (Cx43) is phosphorylated on Tyr247 and Tyr265 and this results in a dramatic disruption of GJC. (pubmedcentralcanada.ca)
- This loss of GJC does not occur in mammalian cells that co-express v-Src together with a mutant form of Cx43 with phenylalanine mutations at the Tyr247 and Tyr265 sites and tyrosine phosphorylation on Cx43 is dramatically reduced in these cells ( 1 , 5 ). (pubmedcentralcanada.ca)
- Over recent years, a few types of mammalian cells have been successfully freeze-dried, such as human erythrocytes and human platelets (Crowe et al. (pubmedcentralcanada.ca)
- The success of freeze-drying mammalian cells was largely dependent on the usage of trehalose. (pubmedcentralcanada.ca)
- A fibrosis progresses, "bridges" of extracellular matrix appear between cells. (phys.org)
- One, "Remodeling of Fibrous Extracellular Matrices by Contractile Cells: Predictions from Discrete Fiber Network Simulations" involved developing simulations that extrapolated the overall remodeling of the extracellular matrix based on the behavior of neighboring pairs of cells. (phys.org)
- Cells are the ones that generate force, and it has to be transmitted through what surrounds the cell, the extracellular matrix, or ECM. (phys.org)
- After 2 weeks in culture, scanning electron microscopy results showed that cells attached and proliferated well on scaffolds, and secreted extracellular matrix were also observed. (biomedsearch.com)
- Integrins are transmembrane receptors that mediate the attachment between a cell and its surroundings, such as other cells or the extracellular matrix (ECM). (hindawi.com)
- Furthermore, fibroblast cells isolated from the Cx43 knockout mouse were found to grow faster in cell culture and to higher saturation densities than fibroblasts that were isolated from wild type mice ( 7 ). (pubmedcentralcanada.ca)
- Mice with a conventional knockout, as well as a T cell-specific deletion, of the Irf8 gene exhibited more efficient T\(_H\)17 cells. (harvard.edu)
- The final goal is to provide the conceptual framework necessary to interpret biological complexity in relevant phenomena such as cell reprogramming, cancer, host-pathogen interaction. (uniroma1.it)
- IRF8 was induced steadily and inhibited T\(_H\)17-cell differentiation during T\(_H\)17 lineage commitment at least in part through its physical interaction with RORγt. (harvard.edu)