Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sum of the weight of all the atoms in a molecule.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The rate dynamics in chemical or physical systems.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Elements of limited time intervals, contributing to particular results or situations.
Established cell cultures that have the potential to propagate indefinitely.
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Proteins prepared by recombinant DNA technology.
Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Deliberate severe and repeated injury to one domestic partner by the other.
A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Transport proteins that carry specific substances in the blood or across cell membranes.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Use of electric potential or currents to elicit biological responses.
Antibodies produced by a single clone of cells.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Proteins found in any species of bacterium.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.
Serologic tests in which a positive reaction manifested by visible CHEMICAL PRECIPITATION occurs when a soluble ANTIGEN reacts with its precipitins, i.e., ANTIBODIES that can form a precipitate.
Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.
The pH in solutions of proteins and related compounds at which the dipolar ions are at a maximum.
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.
An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.
An opisthobranch mollusk of the order Anaspidea. It is used frequently in studies of nervous system development because of its large identifiable neurons. Aplysiatoxin and its derivatives are not biosynthesized by Aplysia, but acquired by ingestion of Lyngbya (seaweed) species.
Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The observable response an animal makes to any situation.
Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Genotypic differences observed among individuals in a population.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.
Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.
Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Proteins found in any species of virus.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Computer-based representation of physical systems and phenomena such as chemical processes.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Glycoproteins found on the membrane or surface of cells.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Separation of particles according to density by employing a gradient of varying densities. At equilibrium each particle settles in the gradient at a point equal to its density. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A type of ion exchange chromatography using diethylaminoethyl cellulose (DEAE-CELLULOSE) as a positively charged resin. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Intellectual or mental process whereby an organism obtains knowledge.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
The time from the onset of a stimulus until a response is observed.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
The coordination of a sensory or ideational (cognitive) process and a motor activity.
Analysis of PEPTIDES that are generated from the digestion or fragmentation of a protein or mixture of PROTEINS, by ELECTROPHORESIS; CHROMATOGRAPHY; or MASS SPECTROMETRY. The resulting peptide fingerprints are analyzed for a variety of purposes including the identification of the proteins in a sample, GENETIC POLYMORPHISMS, patterns of gene expression, and patterns diagnostic for diseases.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
Measurement of the intensity and quality of fluorescence.
The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
Refers to animals in the period of time just after birth.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The process by which two molecules of the same chemical composition form a condensation product or polymer.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Sites on an antigen that interact with specific antibodies.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.
Presence of warmth or heat or a temperature notably higher than an accustomed norm.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
The relationships of groups of organisms as reflected by their genetic makeup.
The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Substances elaborated by viruses that have antigenic activity.
The function of opposing or restraining the excitation of neurons or their target excitable cells.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
The selecting and organizing of visual stimuli based on the individual's past experience.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Forms. Lists. Illustrations. Business publications (09) Presentation in historical form. Legal and historical sources (091) ... The idea that the RBU should take the form of a card catalogue came from the young American zoologist Herbert Haviland Field, ... UDC codes from different tables can be combined to present various aspects of document content and form, e.g. 94(410)"19"(075) ... Table 1c (0...) Common auxiliaries of form. Table 1d (1/9) Common auxiliaries of place. Table 1e (=...) Common auxiliaries of ...
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forms). CS1 maint: discouraged parameter (link) John Shakespear (1817). A Dictionary, Hindūstānī and English. p. 300. H. چاچا ... forms). CS1 maint: discouraged parameter (link) "Meaning of چاچا". Rekhta. Retrieved 8 March 2020. PLATTS DICTIONARY: چاچا चाचा ... First form ('I') Patni (पत्नी, - One's wife (used mainly by the Hindu community) Biwi (बीवी, بیوی) - One's wife Pati (पती, پتی ...
MOST form or POLST form) will vary by your state. In some states - it is called a MOST order form (Medical Order for Scope of ... The Vial of Life form is a practical way to keep all of that information in one place. In 1981, the Sacramento chapter of the ... The Vial of Life was named after the prescription bottles that were originally used to store a medical information form inside ... When a patient first starts with their Vial of Life kit, they must complete a medical information form about their medical ...
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Forms. Brigidine College. 2007. Archived from the original (PDF) on 30 August 2007. Retrieved 19 June 2007. "AHISA Schools". ...
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Often a committee is formed to study the matter, and an answer is reported and adopted by a vote of the delegates at a ... "Forms , Church of the Brethren". Church of the Brethren. Retrieved June 15, 2016. Annual Conference, Church of the Brethren ( ... At the Annual Conference in Ocean Grove, New Jersey, the next year, a group of conservative Brethren responded by forming the ... He met with other progressives on June 6 and 7, 1883, and together they formed the Brethren Church. The remaining middle group- ...
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"Forms". "Archived copy" (PDF). Archived from the original (PDF) on 2015-09-24. Retrieved 2016-02-13. CS1 maint: discouraged ... There is no requirement of citizenship or residency (although different forms, and slightly different requirements apply). A ... Non-Resident Firearms Declaration form that has been confirmed by a Canada Border Services Agency officer serves as a temporary ...
Name and Form) as condition before it can exist: "With Name and Form as condition, Sense Gates arise." Ṣaḍāyatana is also the ... a bhikkhu understands the eye and material forms and the fetter that arises dependent on both (eye and forms); he understands ... Forms are aflame. Consciousness at the eye is aflame. Contact at the eye is aflame. And whatever there is that arises in ... In general, in the Pali Canon, the aggregate of material form includes the five material sense organs (eye, ear, nose, tongue ...
MacDonald, Matthew (2002). "Forms". User Interfaces in VB .NET: Windows Forms and Custom Controls. Apress. p. 158. doi:10.1007/ ... By default, the title bar and the window borders of Windows Forms-based applications are rendered using the user's preferred ... Grossman, Seth (January 2001). "Using Windows XP Visual Styles With Controls on Windows Forms". MSDN. Microsoft. Archived from ...
VA Form 21-0960P-3, OCT 2012)" (PDF). VBA Forms. Department of Veterans Affairs. Archived (PDF) from the original on February ... VA has separate forms for PTSD generally and PTSD "secondary to personal assault". Prior to 2014, VA C&P examiners determined ... When you file a disability claim, you'll also need to fill out one of these additional forms: A Statement in Support of Claim ... Some VA facilities prohibit examiners from using symptom validity tests to screen or assess for malingering and other forms of ...
Provisional Forms ISBN 8364177265 Media related to Maria Bartuszova at Wikimedia Commons images of Bartuszová's work at Alison ... From the 1980s, her work was dominated by pure, ovoid forms, such as hollowed eggs and shells, and idealized shapes that had ... Provisional Forms". Museum of Modern Art in Warsaw. Retrieved 27 November 2019. CS1 maint: discouraged parameter (link) Phaidon ... She created sculptures that enabled those unable to see to get to know various forms and textures, to differentiate between ...
Rosen, Charles (1988). Sonata Forms. New York: W. W. Norton. ISBN 9780393302196.CS1 maint: ref duplicates default (link) String ... The main part of the Minuet is in minuet sonata form, while "the contrasting major-mode Trio ... is ... almost embarrassingly ...
CS1 maint: discouraged parameter (link) Segal, Victoria (December 2019). "Alien Forms". Q (405): 111. Hermes, Will (8 November ...
Here the imaginary floating forms dominate the scene; they dwarf the forms of visible reality, as represented by the fleshy ... On his illustration The Completed Eucharistic Form "the thought-form takes a mosque-like appearance with minarets rising from ... titled Thought-Forms, a record of clairvoyant investigation. The frontispieces of both Thought-Forms and Man Visible and ... "structured according to criteria presented in Thought-Forms, in particular the section of the book that describes the forms ...
"Power Engineering Magazine". Sub Forms. Retrieved 31 October 2015. "PennWell Corp. and NewBay Media Acquired By UK Firms". ...
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"Poetry Forms". Stanza - Poetry Forms. Retrieved 31 January 2021. "poets.org". Retrieved 31 January 2021. For long or anceps in ... The form is two hendecasyllabic verses, and a third verse beginning the same way and continuing with five additional syllables ... Sebastian Klonowic wrote a long poem, Flis, using the form. The formula of 11/11/11/5 syllables was so attractive that it can ... The Sapphic stanza, named after Sappho, is an Aeolic verse form spanning four lines (although originally three in the poetry of ...
"Puppet Forms". ccrtindia.gov.in. Centre for Cultural Resources and Training. Retrieved 30 October 2016. The puppets are large ... It is said that Raja Harishchandra's story in the form of an animated slide show was an influence behind prolific filmmaker ...
"Eduardo Kobra". Urban Forms. 2019. Walde, C (2015). Murals XXL. New York: Thames and Hudson. p. 98. Lark, J (2014). "Eduardo ...
... in the 1901 book Thought-forms, divides them into three classes: forms in the shape of the person who creates them, forms that ... Panchadsi, Swami (1912). "Thought Form". The Human Aura: Astral Colors and Thought Forms. Yoga Publication Society. pp. 47-54. ... "Three classes of thought-forms". Thought-Forms. The Theosophical Publishing House. Archived from the original on 10 December ... A Buddha or other realized being is able to project many such nirmitas simultaneously in an infinite variety of forms in ...
Some species of the Apiaceae form tumbleweeds from their flower umbels, much as some Amaryllidaceae do. In the Asteraceae, the ... Among the Amaranthaceae (s.s.) that form tumbleweeds, there are several species of Amaranthus, such as Amaranthus albus, native ... The light, open, globular structures form very effective tumbleweed diaspores, dropping their seeds usually within a few days ... Also in the Asteraceae, Lessingia glandulifera, native to America, sometimes forms tumbleweeds; it grows on sandy soils in ...
The theory of modular forms (and, more generally, automorphic forms) also occupies an increasingly central place in the toolbox ... However, in the form that is often used in number theory (namely, as an algorithm for finding integer solutions to an equation ... In its basic form (namely, as an algorithm for computing the greatest common divisor) it appears as Proposition 2 of Book VII ... Quadratic forms. Following Fermat's lead, Euler did further research on the question of which primes can be expressed in the ...
"Solvent Forms". Cite journal requires ,journal= (help) "Jared Pappas-Kelley , Teesside University - Academia.edu". egs.academia ... he is currently organizing a group exhibition that he is co-curating with Natasha Chuk entitled Solvent Forms. In addition, ... first job after graduating from university was in the Bomis/Nupedia offices where Wikipedia was first taking form, and he along ...
"College of Natural Resources" (PDF). Forms & Petitions. University of California, Berkeley. February 2016. Riggs, William; ...
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Floating Forms. Kerber Verlag Berlin, 2006. ISBN 393802576X Gerschel, Stephane and Marc Jacobs. Louis Vuitton: ICONS. Assouline ... CS1 maint: discouraged parameter (link) Lehmann, Ulrike, Floating Forms Archived 2015-11-17 at the Wayback Machine (May 16, ... forms and materials. The artist's inventory of video works currently enlists more than 60 titles, with multi-channel ...
Paleozoic Forms; Treatise on Invertebrate Paleontology Part L, Ammonoidea. Geological Society of America and University of ... Neoicoceratoidea comprises forms previously (Miller et al) included in the Neoioceratidae and Metalegoceratidae, previously ...
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... these are often trickier to form than simply adding -s to the end of a noun. ... one formed with `s and one formed in a different way. Usually the form with `s is used in less formal English. ... Plural Forms of Nouns Nouns ending with a long vowel sound and the sound /θ/ have their plural forms pronounced as ending in / ... Even when a noun referring to an animal has a plural form ending in `s, it is quite common to use the form without `s to ...
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Next: Interval Forms, Previous: Modulo Forms, Up: Data Types 4.11 Error Forms. An error form. is a number with an associated ... Error forms may also be composed of HMS forms. For best results, both the mean and the error should be HMS forms if either one ... Error forms and complex numbers can be mixed; the formulas shown above are used for complex numbers, too; note that if the ... To enter an error form during regular numeric entry, use the p. ("plus-or-minus") key to type the . +/-. symbol. (If you try ...
  • Toggle this column head to view metadata forms alphabetically by name. (dcbar.org)
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  • The most commonly required documents for sending an international shipment include the Commercial Invoice, Export Declaration, Certificate of Origin, and the Toxic Substances Control Act form. (fedex.com)
  • This form was revised on May 19, 2016 to incorporate changes to animal testing at the State Public Health Laboratory. (ct.gov)
  • For Tax Year 2018, you will no longer use Form 1040A or Form 1040EZ , but instead will use the redesigned Form 1040 . (irs.gov)
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  • For students earning 6 or more college credits, the immunization form is submitted online to the NYU Student Health Center. (nyu.edu)
  • HSLDA members may use one of these forms, either to submit their immunization records or file religious exemption. (hslda.org)
  • Informed Consent form to use for research involving video or audio recordings. (umass.edu)
  • Get the facts about Delgado Community College tuition increase, submitting required application forms, and accessing historical award data online. (delgadocommunitycollege.org)
  • Google Forms is only available as a web application. (wikipedia.org)
  • This request form should ONLY be used when the Application for Graduation in Minerva is closed . (mcgill.ca)
  • Filing tips & updates, notices, and other helpful materials to assist you in preparing your Form 5500 (5500-EZ) return. (irs.gov)
  • Typically, this is to an HTTP server, but you can also email form contents for asynchronous processing. (w3.org)
  • All completed forms may be submitted via email, fax, or mailed directly to the Federal Select Agent Program. (cdc.gov)
  • This form is collecting email addresses. (google.com)
  • In Settings, users can make changes that affect all new forms, such as always collecting email addresses. (wikipedia.org)
  • Students will receive an email with links to forms and submission instructions after admission to their program. (nyu.edu)
  • Beliefs of tablets authorization body alterations, cialis form indian pharmacies narcotics, and many companies are on dysfunction throughout asia. (yarlcuisine.com)
  • The Course Deletion/Change Request form is to be used to request course deletions and changes in course prefix, title, number, or a combination of. (shsu.edu)
  • The New Course Addition Request form is to be used to request a new course. (shsu.edu)
  • The Course Description Update Request form is to be used to request a course description change to an existing course in the SHSU course inventory. (shsu.edu)
  • The Online Program Request form is to be used to request that a new program or an existing program be delivered either electronic-to-individuals (i.e., online), electronic-to-groups, or off-campus face-to-face. (shsu.edu)
  • The Title Change Request form is to be used to request a change to the title of an existing degree program. (shsu.edu)
  • The CIP Code Change Request form is to be used to request a change to the Classification of Instructional Programs (CIP) code of an existing degree program, meaning the degree program must already be on SHSU's program inventory. (shsu.edu)
  • The Semester Credit Hour (SCH) Change Request form is to be used to request a change in the number of semester credit hours (SCH) required for a degree program already on SHSU's program inventory. (shsu.edu)
  • The Administrative Unit Change Request form is to be used to request a change to an academic administrative unit. (shsu.edu)
  • The Late Proposal Approval Request form is used to request an exception to the VCRE's mandatory proposal submission procedure. (umass.edu)
  • Use this request form if you wish to switch from the Honours section of a course to the Major (regular) section. (mcgill.ca)
  • Check with the financial aid office for assistance with filling out FAFSA forms, registration deadlines, and tuition payment program requirements. (delgadocommunitycollege.org)
  • All forms for the Select Agents Program have been reviewed and approved by the Office of Management and Budget as prescribed by the Paperwork Reduction Act of 1995. (cdc.gov)
  • The New Degree Program Proposal form is to be used to propose a new bachelor or master's degree program that is not 1) in Engineering and/or 2) does not have an estimated cost of more than $2 million in the first five years of operation. (shsu.edu)
  • The New Doctoral Program Proposal form is to be used to propose a new doctoral degree program. (shsu.edu)
  • In order to participate in NYU Summer Programs, all students must submit required forms at least two weeks before the start of their program . (nyu.edu)
  • The forms a student will submit will depend on their age, on whether or not they will be living on campus or commuting for their program, and whether or not they will be earning six college credits or more through their program. (nyu.edu)
  • This form should be filed along with the affidavit by parents who are conducting a home education program and claiming a religious exemption from immunizations and/or health and medical services for their children. (hslda.org)
  • you're going to need a program that works within the form. (wired.com)
  • To save a filled-in form for later use, you need the full Adobe Acrobat Program. (fws.gov)
  • This Club Sport Travel Itinerary Form will be used by our students in the Club Sports program who travel. (uwec.edu)
  • Program modification not addressed by other forms. (astate.edu)
  • That's according to financial disclosure forms released voluntarily by Trump. (npr.org)
  • We're getting another small clue about President Trump's overall financial picture after the president released some disclosure forms late last week. (npr.org)
  • ZARROLI: The federal disclosure forms released Friday don't say exactly how much his properties are worth, but they do give ballpark numbers. (npr.org)
  • Select the form owner's department from the drop-down menu. (uwec.edu)
  • The Department of Buildings will only accept this new form for filing. (nyc.gov)
  • The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. (sec.gov)
  • If you need assistance completing a form or filing information, contact the Consumer & Governmental Affairs Bureau at 1-888-CALL-FCC. (fcc.gov)
  • NOTE: Mailing addresses for the forms that do not require electronic filing are located in the fee filing guides. (fcc.gov)
  • Filing tips to assist you in preparing your Form 5330 return. (irs.gov)
  • Notification, certification, and decommissioning forms and instructions, as well as system inspection and maintenance checklists. (mass.gov)
  • Individuals may digitally sign the select agent forms by following these instructions . (cdc.gov)
  • Information, forms, and instructions for owner/operators of specific categories of boilers. (mass.gov)
  • Certification forms and instructions for product and vehicle manufacturers, recyclers, and scrap facilities. (mass.gov)
  • Forms and instructions for business and institutions subject to Massachusetts Rideshare Regulation annual reporting requirements. (mass.gov)
  • Forms and instructions for facilities with specific SIC Codes that discharge 25,000 gallons per day or less to smaller treatment plants. (mass.gov)
  • Instructions specific to items on the form are included in brackets. (umass.edu)
  • Note you are not allowed to nest FORM elements! (w3.org)
  • Note that, if the `ch' at the end of a noun is pronounced as /k/, you add `s', not `es', to form the plural. (thefreedictionary.com)
  • However, note that Calc considers an error form with real components to represent a real number, not a complex distribution around a real mean. (gnu.org)
  • Use this form to request a customized letter for the purpose of obtaining immigration documents (e.g.: post-graduate work permit, visa, permanent residency, etc). (mcgill.ca)
  • This site contains only public permit forms. (fws.gov)
  • Local Tour Permit - Interactive form for unit trips under 500 miles. (meritbadge.org)
  • Many people will only need to file Form 1040 and no schedules. (irs.gov)
  • Form 1040-ES is used by persons with income not subject to tax withholding to figure and pay estimated tax. (irs.gov)
  • Modification of or deviation from the information provided in an ACP7 form must be reported immediately in writing to the Department of Environmental Protection if the change refers to the building owner, contractor, air monitoring firm, amount of ACM to be disturbed, the dates of the project, or the project location. (nyc.gov)
  • Information provided to the Department of Public Health by submitting completed report forms may help prevent disease, injury and disability, and assure the condition in which people can be healthy. (ct.gov)
  • Forms for agencies outside the Department of Justice can be found at Forms.gov . (justice.gov)
  • DOE's forms are developed within the Department and approved by the DOE Forms Manager. (energy.gov)
  • The ACR practice management department provides encounter forms to help practices save time and capture the necessary information needed for patient visits. (rheumatology.org)
  • These are the most frequently requested U.S. Department of Labor forms. (dol.gov)
  • This page contains the forms, checklists and guidance documents the Indiana Department of Environmental Management uses when inspecting both permitted and regulated facilities in Indiana. (in.gov)
  • The challenge of the approval is walmart the support of regions you have to cialis form indian pharmacies traverse from the impotence to the most cultural maximum. (yarlcuisine.com)
  • When university salary (effort) is committed in a proposal for sponsored funding, faculty must use the Cost Sharing Approval Form to obtain the necessary approvals for the proposed in-kind effort. (umass.edu)
  • If so, it is not necessary to complete a PD-23 form. (ct.gov)
  • Complete Form W-4 so that your employer can withhold the correct federal income tax from your pay. (irs.gov)
  • If you will be completing the form by hand, use the print-only PDF, then print, complete and sign the form. (cdc.gov)
  • You can complete some forms online, while you can download and print all others. (dol.gov)
  • You can find a complete, searchable list of forms in our secure Student Portal. (edu.au)
  • The following forms are intended to help individuals complete Timeline Followback calendars for a multiple of different behaviors (i.e., alcohol-use, drug-use, cigarette-use, internet-use). (nova.edu)
  • Then, access and complete the appropriate referral form. (childrens.com)
  • These are examples of forms that may be needed by FSIS employees and applicants for employment. (usda.gov)
  • Applicants must have a valid Clinical Verification (CV) Form on file in order to be approved to sit for an ARDMS specialty examination (first-time Applicants and Re-applicants). (ardms.org)
  • Standard Clinical Verification forms are intended for Applicants residing in the U.S or Canada. (ardms.org)
  • Applicants interested in requesting an exception should send their letter to: ARDMS, ATTN: CV Form Exceptions, 1401 Rockville Pike, Suite 600, Rockville, MD 20852-1402. (ardms.org)
  • Use this form to request access to Health Insurance Portability and Accountability Act (HIPAA) data from individuals. (umass.edu)
  • The oral and short verision of the written consent form is designed to provide a mechanism for individuals with limited English language proficiency to participate in human subject research where their lack of proficiency would otherwise be a barrier to their participation. (umass.edu)
  • HTML fill-out forms can be used for questionaires, hotel reservations, order forms, data entry and a wide variety of other applications. (w3.org)
  • Use this form to order a transcript or other return information free of charge, or designate a third party to receive the information. (irs.gov)
  • Employers must file a Form W-2 for each employee from whom Income, social security, or Medicare tax was withheld. (irs.gov)
  • The SCRIPT attribute of the FORM element specifies the script via a URI. (w3.org)
  • When using a variable pitch font, the SIZE attribute sets the width in en units (half the point size). (w3.org)
  • attribute and the most simple form element, the ever-popular textbox. (wired.com)
  • attribute, which has been set as text, is what makes this form a textbox. (wired.com)
  • attribute of the form is going to send the user information to a script, which will then read it. (wired.com)
  • Use this form to request a monthly installment plan if you cannot pay the full amount you owe shown on your tax return (or on a notice we sent you). (irs.gov)
  • See information about Fee-for-Service Advance Beneficiary Notice of Noncoverage (ABN) form uses and requirements. (rheumatology.org)
  • Use this form when children aged 7-12 are a subject research population, the regulations require the assent of the child or minor and the permission of the parent(s), in place of the consent of the subjects. (umass.edu)
  • You can plan events, make a survey or poll, give students a quiz, or collect other information in an easy, streamlined way with Google Forms. (google.com)
  • How are teachers and students using Google Forms? (google.com)
  • AESP-14's primary mission was to test a CubeSat form factor, power system, and onboard computer, developed by space systems engineering students in Brazil. (arrl.org)
  • Forms require the signatures of both students and parents. (nyu.edu)
  • The information on this form is required for clinic, and students will not be allowed to attend clinic until the form is completed. (utc.edu)
  • The information on this form is required by the University, and students will not be permitted to register for classes until the form is completed and returned. (utc.edu)
  • Students will provide the clinical site, center coordinator of clinical education, and the clinical instructor with feedback using the APTA Physical Therapist Student Evaluation: Clinical Experience and Clinical Instruction Form. (utc.edu)
  • All Internal FWS forms are now located only on the FWS internal SharePoint site (accessible to FWS employees with PIV card). (fws.gov)
  • From the left panel of the Site Administration Dashboard , expand Elements & Forms and choose Metadata Forms to display this dialog. (dcbar.org)
  • Binding Type - Use this dropdown to filter forms by binding types in use at your site. (dcbar.org)
  • to display the Delete Metadata Form dialog for removing a selected form from your site. (dcbar.org)
  • All tasks are cialis form indian pharmacies not for people and best therapeutics. (yarlcuisine.com)
  • The following forms are use to support various tasks associated with your student record. (ucalgary.ca)
  • Click the My Tasks tab to view any forms that require your input. (uwec.edu)
  • Breezing Forms is the only form manager around that you can throw at almost anything and yet is able to manage even the most complex tasks. (joomla.org)
  • File widgets for attaching files to forms. (w3.org)
  • But unlike formLets in its current form, it permits the definition of widgets. (haskell.org)
  • Use this form to request access to Kuali as an adjunct or pending employee. (umass.edu)
  • Use this form to request new access or a change to your existing access if you are a current permanent employee. (umass.edu)
  • Many platforms have existing conventions for forms, for example, using Tab and Shift-Tab to move the keyboard focus forwards and backwards between fields, and using the Enter (aka Return) key to submit the form. (w3.org)
  • Submit the UGRT form and associated documentation to your departmental office. (mcgill.ca)
  • If you do not have a valid CV form on file, you will need to submit a new form with a current date. (ardms.org)
  • Form may be used as a handout to debrief participants on any aspect of a research study considered sensitive. (umass.edu)
  • To view some of these forms, you will need to have the free Adobe Acrobat Reader installed on your computer. (usda.gov)
  • Online form submission helps Veteran Student Services expedite processing, which allows you to receive your benefits sooner. (ou.edu)