Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
Contractile activity of the MYOCARDIUM.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The valve between the left atrium and left ventricle of the heart.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The hemodynamic and electrophysiological action of the HEART VENTRICLES.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The hollow, muscular organ that maintains the circulation of the blood.
The circulation of blood through the CORONARY VESSELS of the HEART.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.
Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.
Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.
Act of listening for sounds within the heart.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Timing the acquisition of imaging data to specific points in the cardiac cycle to minimize image blurring and other motion artifacts.
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Graphic registration of the heart sounds picked up as vibrations and transformed by a piezoelectric crystal microphone into a varying electrical output according to the stresses imposed by the sound waves. The electrical output is amplified by a stethograph amplifier and recorded by a device incorporated into the electrocardiograph or by a multichannel recording machine.
The graphic recording of chest wall movement due to cardiac impulses.
A twisting deformation of a solid body about an axis. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Resistance and recovery from distortion of shape.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
This structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES.
The hemodynamic and electrophysiological action of the right HEART VENTRICLE.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The hemodynamic and electrophysiological action of the LEFT ATRIUM.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The innermost layer of the heart, comprised of endothelial cells.
The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.
The sounds heard over the cardiac region produced by the functioning of the heart. There are four distinct sounds: the first occurs at the beginning of SYSTOLE and is heard as a "lubb" sound; the second is produced by the closing of the AORTIC VALVE and PULMONARY VALVE and is heard as a "dupp" sound; the third is produced by vibrations of the ventricular walls when suddenly distended by the rush of blood from the HEART ATRIA; and the fourth is produced by atrial contraction and ventricular filling.
The hemodynamic and electrophysiological action of the HEART ATRIA.
Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.
A malformation that is characterized by a muscle bridge over a segment of the CORONARY ARTERIES. Systolic contractions of the muscle bridge can lead to narrowing of coronary artery; coronary compression; MYOCARDIAL ISCHEMIA; MYOCARDIAL INFARCTION; and SUDDEN CARDIAC DEATH.
Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Pathological conditions involving the HEART including its structural and functional abnormalities.
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
The veins and arteries of the HEART.
The chambers of the heart, to which the BLOOD returns from the circulation.
A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis.
Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Elements of limited time intervals, contributing to particular results or situations.
Radiography of the heart and great vessels after injection of a contrast medium.
A fetal blood vessel connecting the pulmonary artery with the descending aorta.
Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
The hemodynamic and electrophysiological action of the RIGHT ATRIUM.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Conical muscular projections from the walls of the cardiac ventricles, attached to the cusps of the atrioventricular valves by the chordae tendineae.
The repeating contractile units of the MYOFIBRIL, delimited by Z bands along its length.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
Echocardiography amplified by the addition of depth to the conventional two-dimensional ECHOCARDIOGRAPHY visualizing only the length and width of the heart. Three-dimensional ultrasound imaging was first described in 1961 but its application to echocardiography did not take place until 1974. (Mayo Clin Proc 1993;68:221-40)
A valve situated at the entrance to the pulmonary trunk from the right ventricle.
A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.
Distensibility measure of a chamber such as the lungs (LUNG COMPLIANCE) or bladder. Compliance is expressed as a change in volume per unit change in pressure.
A giant elastic protein of molecular mass ranging from 2,993 kDa (cardiac), 3,300 kDa (psoas), to 3,700 kDa (soleus) having a kinase domain. The amino- terminal is involved in a Z line binding, and the carboxy-terminal region is bound to the myosin filament with an overlap between the counter-connectin filaments at the M line.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Inflammation of the PERICARDIUM that is characterized by the fibrous scarring and adhesion of both serous layers, the VISCERAL PERICARDIUM and the PARIETAL PERICARDIUM leading to the loss of pericardial cavity. The thickened pericardium severely restricts cardiac filling. Clinical signs include FATIGUE, muscle wasting, and WEIGHT LOSS.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Motion pictures of the passage of contrast medium through blood vessels.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
The flow of BLOOD through or around an organ or region of the body.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
The valve consisting of three cusps situated between the right atrium and right ventricle of the heart.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.
Non-invasive imaging methods based on the mechanical response of an object to a vibrational or impulsive force. It is used for determining the viscoelastic properties of tissue, and thereby differentiating soft from hard inclusions in tissue such as microcalcifications, and some cancer lesions. Most techniques use ultrasound to create the images - eliciting the response with an ultrasonic radiation force and/or recording displacements of the tissue by Doppler ultrasonography.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
The main trunk of the systemic arteries.
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
The rhythmical expansion and contraction of an ARTERY produced by waves of pressure caused by the ejection of BLOOD from the left ventricle of the HEART as it contracts.
A benign neoplasm derived from connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix, thereby resembling primitive mesenchymal tissue. It occurs frequently intramuscularly where it may be mistaken for a sarcoma. It appears also in the jaws and the skin. (From Stedman, 25th ed)
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.
Physical motion, i.e., a change in position of a body or subject as a result of an external force. It is distinguished from MOVEMENT, a process resulting from biological activity.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
The circulation of the BLOOD through the LUNGS.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
Treatment process involving the injection of fluid into an organ or tissue.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
The vessels carrying blood away from the heart.
A network of tubules and sacs in the cytoplasm of SKELETAL MUSCLE FIBERS that assist with muscle contraction and relaxation by releasing and storing calcium ions.
The condition of an anatomical structure's being dilated beyond normal dimensions.
A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
Narrowing or constriction of a coronary artery.
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.

Ambulatory blood pressure monitoring and progression in patients with IgA nephropathy. (1/2997)

BACKGROUND: Hypertension is a recognized marker of poor prognosis in IgA nephropathy. METHODS: The present study investigated the prevalence of white-coat hypertension, the diurnal rhythm of blood pressure (BP), the effectiveness of antihypertensive drug therapy, and the effect of the above on the progression of the kidney disease in IgA nephropathy. One hundred twenty-six IgA nephropathy patients were selected consecutively for 24-h ambulatory blood pressure monitoring (ABPM). Fifty-five patients were normotensive and 71 were treated hypertensives. Their antihypertensive drugs were angiotensin-converting enzyme inhibitors (ACEI) alone or in combination with calcium-channel blockers (CCB). RESULTS: The mean night-time BP of normotensives (108+/-9/67+/-6 mmHg) was significantly lower than their day-time BP (125+/-8/82+/-7 mmHg, P<0.05). There was no significant difference between the mean day-time and night-time BP in hypertensive patients (125+/-9/82+/-7 mmHg vs 128+/-10/85+/-9 mmHg). The circadian variation of BP was preserved ('dippers') in 82% of the normotensive and 7% of the hypertensive patients (P<0.001). There were 10 'white-coat hypertensives' among the patients classified as normotensives with ABPM (mean office blood pressure 149+/-7/96+/-8 mmHg, 24-h blood pressure 127+/-6/83+/-5 mmHg, P<0.05) and 14 among treated hypertensives (mean office BP 152+/-8/98+/-6 mmHg, 24-h BP 130+/-4/85+/-8 mmHg, P<0.05). There was no difference in mean day-time BP among normotensive and treated hypertensive patients (125+/-8/81+/-5 mmHg vs 128+/-10/85+/-9 mmHg). Hypertensives had significantly higher night-time BP (125+/-9/85+/-9 mmHg) than normotensives (108+/-9/67+/-6 mmHg, P<0.001). There was no difference in serum creatinine levels among the different groups at the time of the ABPM. However, thirty-six+/-4.1 months after the ABPM, hypertensive patients (n=52) had higher serum creatinine levels (124+/-32 micromol/l) than at the time of the ABPM (101+/-28 micromol/l). The serum creatinine of normotensive patients (n=43) did not change during the follow-up period. 'Non-dipper' normotensives (n=10) had significantly higher serum creatinine levels at the end of the follow-up period than at its beginning (106+/-17 micromol/l vs 89+/-18 micromol/l, P<0.05). There was no increase in serum creatinine of 'dipper' normotensives. The mean serum creatinine of 'white-coat hypertensives' was significantly higher at the end of the study period than at its beginning. CONCLUSIONS: There is no diurnal blood pressure variation in most of the hypertensive IgA nephropathy patients. ACEI and CCB treatment have better effect on day-time than night-time hypertension. The lack of the circadian rhythm and 'white-coat hypertension' seems to accelerate the progression of IgA nephropathy.  (+info)

Restriction of placental and fetal growth in sheep alters fetal blood pressure responses to angiotensin II and captopril. (2/2997)

1. We have measured arterial blood pressure between 115 and 145 days gestation in normally grown fetal sheep (control group; n = 16) and in fetal sheep in which growth was restricted by experimental restriction of placental growth and development (PR group; n = 13). There was no significant difference in the mean gestational arterial blood pressure between the PR (42.7 +/- 2.6 mmHg) and control groups (37.7 +/- 2.3 mmHg). Mean arterial blood pressure and arterial PO2 were significantly correlated in control animals (r = 0.53, P < 0.05, n = 16), but not in the PR group. 2. There were no changes in mean arterial blood pressure in either the PR or control groups in response to captopril (7.5 microg captopril min-1; PR group n = 7, control group n = 6) between 115 and 125 days gestation. After 135 days gestation, there was a significant decrease (P < 0.05) in the fetal arterial blood pressure in the PR group but not in the control group during the captopril infusion (15 microg captopril min-1; PR group n = 7, control group n = 6). 3. There was a significant effect (F = 14.75; P < 0.001) of increasing doses of angiotensin II on fetal diastolic blood pressure in the PR and control groups. The effects of angiotensin II were different (F = 8.67; P < 0.05) in the PR and control groups at both gestational age ranges. 4. These data indicate that arterial blood pressure may be maintained by different mechanisms in growth restricted fetuses and normally grown counterparts and suggests a role for the fetal renin-angiotensin system in the maintenance of blood pressure in growth restricted fetuses.  (+info)

Contribution of L-type Ca2+ current to electrical activity in sinoatrial nodal myocytes of rabbits. (3/2997)

The role of L-type calcium current (ICa,L) in impulse generation was studied in single sinoatrial nodal myocytes of the rabbit, with the use of the amphotericin-perforated patch-clamp technique. Nifedipine, at a concentration of 5 microM, was used to block ICa,L. At this concentration, nifedipine selectively blocked ICa,L for 81% without affecting the T-type calcium current (ICa,T), the fast sodium current, the delayed rectifier current (IK), and the hyperpolarization-activated inward current. Furthermore, we did not observe the sustained inward current. The selective action of nifedipine on ICa,L enabled us to determine the activation threshold of ICa,L, which was around -60 mV. As nifedipine (5 microM) abolished spontaneous activity, we used a combined voltage- and current-clamp protocol to study the effects of ICa,L blockade on repolarization and diastolic depolarization. This protocol mimics the action potential such that the repolarization and subsequent diastolic depolarization are studied in current-clamp conditions. Nifedipine significantly decreased action potential duration at 50% repolarization and reduced diastolic depolarization rate over the entire diastole. Evidence was found that recovery from inactivation of ICa,L occurs during repolarization, which makes ICa,L available already early in diastole. We conclude that ICa,L contributes significantly to the net inward current during diastole and can modulate the entire diastolic depolarization.  (+info)

Changes in porcine transmitral flow velocity pattern and its diastolic determinants during partial coronary occlusion. (4/2997)

OBJECTIVES: To define the mechanical determinants of transmitral flow and the effect of heart rate during regional ischemia. BACKGROUND: Myocardial ischemia changes the transmitral flow velocity pattern due to disease-induced changes in the heart's diastolic properties. METHODS: Regional ischemia was produced in 12 pigs by partially occluding the left anterior descending coronary artery until segment-length shortening in the ischemic region fell by 20%. Transmitral flow velocity patterns and their determinants were measured under two conditions, baseline and ischemia, at two heart rates, 70 and 90 beats/min. RESULTS: Regional ischemia had a significant effect on two determinants of filling: relaxation, which was slower, and chamber stiffness, which increased. These changes were associated with reduced contractility and increased myocardial stiffness, resulting in an early transmitral flow pattern that was flatter and narrower, but no change in the late flow pattern. Moderate increases in heart rate accelerated relaxation and decreased atrioventricular pressure gradient but had no effect on contractility or myocardial or chamber stiffness, resulting in an early transmitral flow pattern that was flatter and narrower and an increased late flow velocity. CONCLUSIONS: This model of regional ischemia leads to a flatter and narrower early transmitral flow velocity pattern and no change in late flow due to a combination of slowed left ventricular relaxation and increased chamber stiffness. Reflex increases in heart rate that accompany ischemia tend to mask this effect.  (+info)

Decreased left ventricular filling pressure 8 months after corrective surgery in a 55-year-old man with tetralogy of Fallot: adaptation for increased preload. (5/2997)

A 55-year-old man with tetralogy of Fallot underwent corrective surgery. Left ventricular filling pressure increased markedly with increased left ventricular volume one month after surgery, then decreased over the next 7 months, presumably due to increased left ventricular compliance.  (+info)

Cell death in acromegalic cardiomyopathy. (6/2997)

BACKGROUND: Prolonged untreated acromegaly leads to a nonspecific myopathy characterized by ventricular dysfunction and failure. However, the mechanisms responsible for the alterations of cardiac pump function remain to be defined. Because cell death is implicated in most cardiac disease processes, the possibility has been raised that myocyte apoptosis may occur in the acromegalic heart, contributing to the deterioration of ventricular hemodynamics. METHODS AND RESULTS: Ten acromegalic patients with diastolic dysfunction and 4 also with systolic dysfunction were subjected to electrocardiography, Holter monitoring, 2-dimensional echocardiography, cardiac catheterization, and biventricular and coronary angiography before surgical removal of a growth hormone-secreting pituitary adenoma. Endomyocardial biopsies were obtained and analyzed quantitatively in terms of tissue scarring and myocyte and nonmyocyte apoptosis. Myocardial samples from papillary muscles of patients who underwent valve replacement for mitral stenosis were used for comparison. The presence of apoptosis in myocytes and interstitial cells was determined by confocal microscopy with the use of 2 histochemical methods, consisting of terminal deoxynucleotidyl transferase (TdT) assay and Taq probe in situ ligation. Acromegaly was characterized by a 495-fold and 305-fold increase in apoptosis of myocytes and nonmyocytes, respectively. The magnitude of myocyte apoptosis correlated with the extent of impairment in ejection fraction and the duration of the disease. A similar correlation was found with the magnitude of collagen accumulation, indicative of previous myocyte necrosis. Myocyte death was independent from the hormonal levels of growth hormone and insulin-like growth factor-1. Apoptosis of interstitial cells did not correlate with ejection fraction. CONCLUSIONS: Myocyte cell death, apoptotic and necrotic in nature, may be critical for the development of ventricular dysfunction and its progression to cardiac failure with acromegaly.  (+info)

Hypertension treatment and the prevention of coronary heart disease in the elderly. (7/2997)

Both isolated systolic hypertension (>140 mm Hg/<90 mm Hg) and systolic/diastolic hypertension (>140 mm Hg/>90 mm Hg) are major risk factors for cardiovascular disease in the elderly. Specific antihypertensive drug therapy is available if lifestyle interventions fail to reduce blood pressure to a normal level. Diuretics and beta blockers both reduce the occurrence of adverse events related to cerebrovascular disease; however, diuretics are more effective in reducing events related to coronary heart disease. Treated patients are less likely to develop severe hypertension or congestive heart failure. In most instances, low-dose diuretic therapy should be used as initial antihypertensive therapy in the elderly. A long-acting dihydropyridine calcium channel blocker may be used as alternative therapy in elderly patients with isolated systolic hypertension. Trials are being conducted to evaluate the long-term effects of angiotensin converting enzyme inhibitors and angiotensin-II receptor blockers in elderly patients with uncomplicated hypertension.  (+info)

Early detection of anthracycline induced cardiotoxicity in asymptomatic patients with normal left ventricular systolic function: autonomic versus echocardiographic variables. (8/2997)

OBJECTIVE: To investigate left ventricular dysfunction in patients who had been treated with anthracycline based chemotherapy. METHODS: Autonomic function was compared with left ventricular diastolic function in 20 asymptomatic women with normal systolic function (left ventricular ejection fraction (LVEF) > 0.50) treated for breast cancer with high dose anthracycline based chemotherapy, and 20 age matched healthy controls. Left ventricular diastolic function was assessed echocardiographically by measuring the early peak flow velocity to atrial peak flow velocity ratio, isovolumic relaxation time, and deceleration time. Heart rate variability analysis was assessed for time domain and frequency domain parameters. RESULTS: The mean (SD) age of the patients was 45 (7) years and the mean LVEF was 0.59 (0.06). The time interval after the end of chemotherapy was 29 (27) months. One or more diastolic variables were abnormal in 50% of the patients. Heart rate variability was abnormal in 85% of patients. Mean values of both time domain and frequency domain parameters were decreased (p < 0.05), in particular the parasympathetic indices. CONCLUSIONS: Autonomic impairment occurs in a large proportion of asymptomatic patients with normal systolic left ventricular function after high dose anthracycline based chemotherapy. In particular, heart rate variability analysis may be a sensitive tool to identify the first signs of cardiotoxicity in these patients.  (+info)

TY - JOUR. T1 - Change in left ventricular diastolic filling patterns in patients with supraventricular tachycardia treated by radiofrequency ablation. T2 - A Doppler echocardiographic study. AU - Shyu, K. G.. AU - Lin, J. L.. AU - Chen, J. J.. AU - Ko, Y. L.. AU - Hwang, J. J.. AU - Tseng, Y. Z.. AU - Lien, W. P.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - To evaluate changes in left ventricular diastolic filling patterns resulting from radiofrequency ablation for supraventricular tachycardia (SVT), 44 patients with SVT undergoing radiofrequency ablation (study group), and 16 patients with SVT undergoing electrophysiologic study without ablation (control group) were studied by pulsed Doppler echocardiography. Peak early diastolic filling velocity (E), peak atrial filling velocity (A), and an E/A ratio were obtained from the transmitral flow velocity pattern before and 24-48 h after ablation or electrophysiologic study. In the study ...
A method is described for the continuous recording of changes in the length of a segment of left ventricular myocardium, and its advantages and limitations are discussed. The curve depicting the relation between ventricular diastolic pressure and simultaneous changes in the length of a myocardial segment is presented. For a given increment in pressure, the myocardial segment length increases more at low ventricular diastolic pressure than at high pressure. Atrial systole causes a substantial increase in myocardial segment length when the ventricle is on the sensitive part of its pressure-length curve.. ...
TY - JOUR. T1 - A new approach for evaluation of left ventricular diastolic function. T2 - Spatial and temporal analysis of left ventricular filling flow propagation by color M-mode Doppler echocardiography. AU - Takatsuji, Hiroya. AU - Mikami, Taisei. AU - Urasawa, Kazushi. AU - Teranishi, Jun Ichi. AU - Onozuka, Hisao. AU - Takagi, Chika. AU - Makita, Yasuhiro. AU - Matsuo, Hisashi. AU - Kusuoka, Hideo. AU - Kitabatake, Akira. PY - 1996/2. Y1 - 1996/2. N2 - Objectives. To evaluate left ventricular diastolic function and differentiate the pseudonormalized transmitral flow pattern from the normal pattern, the propagation of left ventricular early filling flow was assessed quantitatively using color M-mode Doppler echocardiography. Background. Because the propagation of left ventricular early filling flow is disturbed in the left ventricle with impaired relaxation, quantification of such alterations should provide useful indexes for the evaluation of left ventricular diastolic function Methods. ...
Potassium depletion exacerbates essential hypertension. Contribution of external forces to left ventricular diastolic pressure: implications for the clinical use of the Starling law
To estimate changes in compliance, we evaluated the effects of sepsis on the end-diastolic pressure-volume relationship (EDPVR) in the left ventricle of rats that had undergone an open thorax procedure. Sepsis was induced in male Wistar Hannover rats (n = 7; 240 to 270 g) by intraperitoneal administration of a slurry of cecal contents; control rats (n = 7) were given 5% dextrose only. On the third day after induction of sepsis, left ventricular (LV) pressure and LV dimensions were recorded simultaneously in animals of both groups. Using a micromanometer and ultrasonic crystals, measurements were obtained at baseline and during the increase of afterload. Blood samples were taken for determination of complete blood count, white blood cell differential count, and lactate concentration, and for bacteriologic examination. Septic rats lost weight, and developed changes in body temperature, ascites, and abscesses in the abdominal and thoracic cavities, gram-negative bacteremia, and increase in heart ...
TY - JOUR. T1 - The natural history of isolated left ventricular diastolic dysfunction. AU - Brogan, Walter C.. AU - Hillis, L. David. AU - Flores, Eduardo D.. AU - Lange, Richard A.. PY - 1992. Y1 - 1992. N2 - study objective: To assess the natural history of isolated left ventricular diastolic dysfunction. materials and methods: Follow-up (average duration, 68 months) was obtained in 51 patients with isolated left ventricular diastolic dysfunction at cardiac catheterization, characterized by (1) an elevated left ventricular end-diastolic pressure; (2) normal left ventricular end-diastolic and end-systolic volumes; (3) normal left ventricular ejection fraction; (4) no coronary artery disease; and (5) no valvular disease. results: During follow-up, seven patients died, but only one died of cardiac causes. Of the 44 living subjects, 20 (45%) noted new-onset symptoms of congestive heart failure, with 11 (25%) of these requiring hospitalization, and 12 (27%) required hospitalization for recurrent ...
In this study we sought to assess the clinical significance of peak negative MVG derived from TDI as a noninvasive indicator of LV diastolic function. By comparing peak negative MVG among patients with or without impairment of systolic and diastolic performance, we have demonstrated that peak negative MVG reflected diastolic abnormalities in these patients. We have also found that peak negative MVG was relatively independent of preload alterations because peak negative MVG was unaltered, while the transmitral flow velocity indices were significantly altered, by passive leg lifting maneuver. Finally, we have found that peak negative MVG showed an improvement by volume-reducing therapy in contrast to the transmitral flow velocity indices, which apparently worsened toward an abnormal relaxation pattern. Thus, peak negative MVG may be a noninvasive indicator of LV diastolic function that is relatively independent of preload alterations, and thereby could be used for the follow-up of patients with ...
Since the gradient between aortic pressure and left ventricular diastolic pressure is a major determinant of coronary blood flow, a change in left ventricular relaxation by its effect on early diastole could diminish early diastolic coronary flow. Two interventions that resulted in impaired left ventricular relaxation, hypothermia, and reperfusion following a left anterior descending coronary artery occlusion were studied to evaluate whether there were associated changes in coronary blood flow. With both interventions, there was a significant prolongation of left ventricular relaxation (p less than 0.01) accompanied by a significant decrease in early diastolic coronary blood flow (p less than 0.01). Verapamil did not have a significant effect on these hemodynamic changes during hypothermia. However, verapamil significantly blunted the effects of reperfusion following ischemia on ventricular relaxation (p less than 0.002) and early diastolic coronary blood flow (p less than 0.01). Thus, impaired ...
Atrial fibrillation (AF) is the most frequent form of arrhythmia, and the number of patients with AF has increased with the rapid aging of society (1). AF is an important risk factor for heart failure (2), wherein left ventricular (LV) diastolic function is more closely related to the symptoms, exercise tolerance, and prognosis of patients compared with systolic function (3,4). In the clinical setting, LV diastolic function is mainly evaluated by the transmitral flow velocity pattern using Doppler echocardiography. Evaluation of LV diastolic function is also needed in patients with AF which is extremely challenging because of the lack of atrial systolic transmitral flow wave and the irregularity of Doppler parameters caused by irregular R-R intervals (5-7).. As an alternative method for evaluating LV diastolic function, mitral annular velocity waveforms, which can be recorded using tissue Doppler echocardiography, have been used. The ratio of early diastolic transmitral flow velocity (E) to ...
TY - JOUR. T1 - Usefulness of tissue doppler and color M-mode indexes of left ventricular diastolic function in predicting outcomes in systolic left ventricular heart failure (from the ADEPT Study). AU - Troughton, Richard W.. AU - Prior, David L.. AU - Frampton, Christopher M.. AU - Nash, Patrick J.. AU - Pereira, Jeremy J.. AU - Martin, Maureen. AU - Fogarty, Annette. AU - Morehead, Annitta J.. AU - Starling, Randall C.. AU - Young, James B.. AU - Thomas, James D.. AU - Lauer, Michael S.. AU - Klein, Allan L.. PY - 2005/7/15. Y1 - 2005/7/15. N2 - The prognostic values of tissue Doppler imaging and color M-mode diastolic indexes were studied in 225 patients who had symptomatic systolic heart failure in the ADEPT study. The primary end point of death, transplantation, or hospitalization due to heart failure occurred in 65 patients and was independently predicted by shorter deceleration time, lower ratio of pulmonary vein systolic to diastolic velocity, and increasing levels of the ratios of ...
Anaesthetics may impair the diastolic function of the heart, but the importance of this finding for patients has not been sufficiently examined. Specially the effects on diastolic function in patients with diastolic dysfunction has to be determined. The aim of this study is to examine the effect of isoflurane (only part I), sevoflurane and desflurane (part I+II) on the diastolic left ventricular function by doppler echocardiography ...
In a number of patients with EF 60% or more, signs of heart failure are clinically detected. As a rule, such a condition is caused by LV diastolic dysfunction (impaired relaxation processes due to ischemia, cardiosclerosis, hypertrophy of the walls, pericardial effusion, etc.). According to a number of researchers, patients with signs of heart failure caused only by diastolic dysfunction constitute 15-25% of all patients with HF.. Diastolic dysfunction of the LV is estimated according to the results of a study of transmitral diastolic blood flow in a pulsed mode. Determine: 1. the maximum speed of the early peak of the diastolic filling M1, 2. the maximum speed in the atrial systole M2, 3. the integral of speed (area under the curve) of the early diastolic filling (VTI E), 4. the integral of the speed of atrial systole (VTI A), 5 LV isovolumetric relaxation time (IVRT), 6. time to slow the early diastolic filling (DT).. In the early stages of LV diastolic dysfunction with a slight increase in ...
TY - JOUR. T1 - Left Ventricular Diastolic Dysfunction in Peritoneal Dialysis. AU - Wu, Cho Kai. AU - Lee, Jen Kuang. AU - Wu, Yi Fan. AU - Tsai, Chia Ti. AU - Chiang, Fu Tien. AU - Hwang, Juey Jen. AU - Lin, Jiunn Lee. AU - Hung, Kuan Yu. AU - Huang, Jenq Wen. AU - Lin, Jou Wei. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Left ventricular diastolic dysfunction (LVDD) is common among patients undergoing peritoneal dialysis (PD). We examined the relationship between LVDD, major adverse cardiovascular events (MACE), and mortality in PD patients. A total of 149 patients undergoing PD with preserved left ventricular systolic function were included and followed for 3.5 years. LVDD was diagnosed (according to the European Society of Cardiology guidelines) by conventional and tissue Doppler echocardiography. Serum high-sensitivity C-reactive protein (hsCRP) was measured. The location and volume of adipose tissue were assessed by computed tomography (CT) at the level of the fourth lumbar vertebra. Subjects with ...
Our study demonstrated an increase in LV relaxation during diastole (inferred from the absolute increase in IVPG) with exercise in both normal subjects and in patients with heart failure. However, this mechanism was significantly impaired in the heart failure group compared with normal subjects. We provided evidence for a strong relationship between the ability to augment the diastolic LV relaxation (represented by the delta IVPG) with exercise and the V̇o2 max. Our study also demonstrated that in patients with heart failure, the decreased ability to augment the diastolic relaxation is responsible for the inability to accommodate the increase in estimated preload during exercise, resulting in higher filling pressures.. Regional diastolic pressure differences have been identified in the left ventricle only recently and their importance in determining diastolic function now becomes evident. Ling and colleagues (25) described the suction effect that develops secondary to a pressure drop between ...
Reliability of updated left ventricular diastolic function recommendations in predicting elevated left ventricular filling pressure and prognosis
Nitroglycerin acts through the NO receptor to activate guanylyl cyclase to increase cGMP and perhaps through other yet undefined mechanisms.. IV nitroglycerin reduces left ventricular diastolic pressure, pulmonary capillary wedge pressure, right ventricular diastolic pressure and right atrial pressure. With continued advancement of dose, there is also a fall in systemic and pulmonary vascular resistance, with a consequent modest rise in cardiac output. Some of the improved hemodynamics is also related to a decrease in mitral regurgitation. Again, the hemodynamic effects are less dramatic than those noted for nitroprusside.. The hemodynamic responses to nitroglycerin tend to gradually decrease with time. Starting as early as 12 to 24 hours into the infusion, the central hemodynamic effects tend to gradually return toward baseline; increasing the dose (infusion rate) may be effective in reversing this trend, but not uniformly so.. This waning of the response has not been fully elucidated, but ...
Background-While age-associated changes in LV diastolic function are well-recognized, limited data exist characterizing measures of diastolic function in older adults, including both reference ranges reflecting the older adult population and prognostically relevant values for incident HF, as well as their associations with circulating biomarkers of heart failure (HF) risk.. Methods-Among 5,801 elderly participants in the Atherosclerosis Risk in Communities (ARIC) study (age range 67-90, mean age 76 ± 5, 42% male, 21% black), we determined the continuous association of diastolic measures (TDI e, E/e, and left atrial size) with concomitant NT-proBNP and subsequent HF hospitalization or death. We also determined sex-specific 10th and 90th percentile limits for these measures using quantile regression in 401 participants free of prevalent cardiovascular disease and risk factors. Results-Each measure of diastolic function was robustly associated with NT-proBNP and incident HF or death. ARIC-based ...
TY - JOUR. T1 - Pioglitazone improves left ventricular diastolic function in subjects with diabetes. AU - Clarke, Geoffrey D. AU - Solis-Herrera, Carolina. AU - Molina-Wilkins, Marjorie. AU - Martinez, Sandra. AU - Merovci, Aurora. AU - Cersosimo, Eugenio. AU - Chilton, Robert J. AU - Iozzo, Patricia. AU - Gastaldelli, Amalia. AU - Abdul-ghani, Muhammad A. AU - Defronzo, Ralph A. PY - 2017/11/1. Y1 - 2017/11/1. N2 - OBJECTIVE To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS Twelve subjectswith T2Dand 12with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and myocardial perfusion were measured with [18F]fluoro-2-deoxy-D-glucose and [15O]H2O positron emission tomography before and after 24 weeks of pioglitazone treatment.Myocardial function and transmitral early diastolic relation/atrial contraction (E/A) flow ratio were ...
Electrocardiographic strain pattern and left ventricular diastolic function in hypertensive patients with left ventricular hypertrophy: The LIFE study Academic Article ...
Standard pulsed Doppler indices are inadequate for assessment of LV relaxation in patients with atrial fibrillation (AF). On the other hand, peak diastolic mitral annulus velocities (Ea) and color M-mode Doppler propagation velocity of mitral inflow (Vp) have been reported as reliable determinants of LV relaxation in those patients. There have been few reports on alteration of LV relaxation during paroxysmal AF. Thirty patients with paroxysmal AF were enrolled in this study. Standard 2 dimensional, color flow Doppler, and tissue Doppler echocardiography were performed before, during AF, and after conversion of AF within 24 hours. LV relaxation was compared among three periods. Early diastolic velocity of TMF (E-wave) was increased, and deceleration time was shortened significantly during AF. Furthermore, systolic velocity of pulmonary vein flow was decreased, and diastolic velocity was increased significantly during AF. These parameters returned to the baseline level after conversion of AF. On ...
Impairment of relaxation, the early phase of ventricular diastole is the first stage of heart diastolic dysfunction. Left ventricular diastolic function can be determined noninvasively by Echo- Doppler - derived mitral valve flow velocities. The addition of pulmonary venous flow pattern enables more accurate assessment of left ventricle diastolic function. The role of the right ventricle in haemodynamic function of the heart is now emphasized. The right ventricle diastolic function can be assess by recording the Doppler tricuspid valve flow pattern. Impaired LV diastolic function usually precedes systolic dysfunction and may cause clinical signs of congestive heart failure. Cigarette smoking is one of the major risk factors for cardiovascular diseases. The aim of the study was to assess left and right ventricular diastolic function in healthy, young and slim smokers before and after smoking one cigarette.. Echocardiographic examination: before and after smoking one cigarette Echocardiographic ...
Summary Background Heart failure occurs in 6% of hyperthyroid patients. Nonetheless, only half of those with hyperthyroidism-related heart failure have impaired left ventricular (LV) systolic function. Thus, diastolic dysfunction may play an important role in the pathogenesis. Methods and results We performed serial echocardiographic examinations in 70 consecutive patients with hyperthyroidism (39 ± 2 years, 47 women) to determine their diastolic function and repeated the examinations 6 months after achieving a euthyroid state. All patients had normal LV systolic function, but diastolic dysfunction was detected in 22 cases (mild: 3, moderate: 15 and severe: 4). The prevalence of diastolic dysfunction increased with age from 17·9% in patients ,40 years to 100% in those ,60 years. Increasing age was the only independent predictor for diastolic dysfunction in hyperthyroid patients. After achievement of a euthyroid state, most patients (16/22, 72%) had completely normalized diastolic function: ...
Systolic impairment is well reported in critically ill patients but diastolic function has been relatively understudied. The objective of this review was to assess tissue Doppler indices of diastolic function in critically ill patients along with any association with mortality.A systematic review of articles in English using Medline, EMBASE, CINAHL and the Cochrane database of systematic reviews. Search terms included diastolic function, diastolic dysfunction, diastolic abnormal*, diastolic heart failure, diastolic filling, ventricular relaxation, pulmonary artery occlusion pressure, left ventricular filling pressure, cardiac dysfunction, intensive care, critical care, critically ill, critical illness, sepsis and septic shock. Only studies of critically ill adult patients (excluding post-cardiac surgical patients) whose diastolic function was assessed using tissue Doppler imaging were included. Study quality was assessed using a modified version of the Newcastle-Ottawa Scale (NOS).Nineteen studies were
Early ventricular fibrillation is not related to infarct size. After 24 h ischemic myocytes have either undergone necrosis or recovered, and the risk of ventricular fibrillation diminishes. The majority of the other complications occur in transmural infarcts. Cardiogenic shock is directly related to the proportion of the left ventricular muscle mass which has been lost. Large infarcts are more likely to be anterior because the left anterior descending coronary aretery supplies more than 60 per cent of the myocardial mass.. Cardiogenic shock may lead to an extension of the area of necrosis ( Fig, 2). Myocardial perfusion is dependent on the relation between aortic diastolic pressure and left ventricular cavity pressure. If aortic pressure falls and left ventricular diastolic pressure rises, subendocardial perfusion throughout the whole left ventricle falls; a circumferential zone of subendocardial necrosis occurs and the centers of the papillary muscles also undergo necrosis ( Fig,... . . 2). ...
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Conclusion: Our findings indicate that myocardial damage in patients with diabetes affects diastolic function before systolic function.Even young patients with diabetics with normal systolic ventricular function have diastolic dysfunction, which serves as a marker of a diabetic cardiomyopathy. Diastolic impairment seems not to correlate with disease duration. HbA1c% can be a very good indicator of long term prognosis. Strong correlation exist between diastolic dysfunction and HbA1c%.. ...
Diastolic dysfunction is a key factor in the pathogenesis of heart failure. Around 50% of cases of heart failure, the hemodynamic correlate of which is increased left ventricular filling pressure, are caused by diastolic dysfunction in the setting of apparently normal systolic function. Due to its high prevalence, diastolic dysfunction is often recognized as an incidental finding. Many patients have Doppler echocardiographic evidence of impaired diastolic function but do not have any symptoms of heart failure at rest. In many of these patients, symptoms of diastolic dysfunction occur only during exercise, as left ventricular filling pressure is normal at rest, but increases with exercise. This implies that filling pressures should also be measured during exercise. The diastolic stress test refers to the evaluation of diastolic function, either invasively or noninvasively, during exercise. This review focuses on the clinical need for diastolic stress testing, both invasively and noninvasively. ...
Although the exercise test was performed after diagnostic catheterisation after an interval of more than three days, non-specific effects of catheterisation and contrast medium might modify postexercise diastolic function. However, the interval between the diagnostic catheterisation and exercise test did not differ significantly among the groups (table 1). Thus the postexercise diastolic dysfunction in group 1 could not be attributed to the effect of catheterisation.. We performed echocardiography serially over a seven day period after exercise. Therefore it is possible that postexercise changes in Doppler indices in patients with dilated cardiomyopathy were a result of measurement errors or day to day variability. However, the mitral flow velocity profile was unchanged throughout the study in the normal subjects and in the dilated cardiomyopathy patients in group 2. Thus day to day variability of Doppler measurements were minimal. Bias related to echocardiographic analysis was also excluded, as ...
In this study, we have performed a comprehensive assessment of systolic and diastolic ventricular function with new noninvasive techniques at rest and on exercise in HFNEF patients and have demonstrated a variety of abnormalities of both systolic and diastolic function. These include reduced radial and longitudinal myocardial systolic strain both at rest and on exercise, reduced systolic and diastolic longitudinal functional reserve (mitral annular velocities fail to rise normally), reduced ventricular systolic rotation at rest that fails to increase normally on exercise, delayed ventricular untwisting with further worsening on exercise associated with a reduced LV suction, and a consequent reduced stroke volume rise on exercise. Recent studies (12-14,37) using similar echocardiographic techniques to ours have elegantly demonstrated the close temporal, functional, and tightly coordinated relationships in normal patients between LV twist during systole, with accompanying mitral annular motion ...
The study by Redfield et al lends further support to the concept that diastolic dysfunction is prevalent, causes symptoms of CHF, and is associated with increased mortality. Diastolic dysfunction refers to a pathologically non-compliant left ventricle (LV) in diastole, which is the result of the combination of slowed LV relaxation and increased stiffness caused by hypertension, diabetes, ischaemia, or a combination.1. The study uses a model of diastolic dysfunction that assumes temporal progression of dysfunction from mild to moderate to severe based on left heart filling patterns obtained by state of the art echo Doppler techniques. Some aspects of this approach are problematic. The temporal progression of diastolic dysfunction has not been shown, the use of echo Doppler parameters was obtained at only a single point in time, and the use of these filling patterns to reflect LV properties in a wide range of patients is not the standard of measurement. Although these limitations should be ...
TY - JOUR. T1 - Isolated Left Ventricular Filling Abnormalities May Predict Interleukin-2-Induced Cardiovascular Toxicity. AU - Citterio, G.. AU - Fragasso, G.. AU - Rossetti, E.. AU - Di Lucca, G.. AU - Bucci, E.. AU - Foppoli, M.. AU - Guerrieri, R.. AU - Matteucci, P.. AU - Polastri, D.. AU - Scaglietti, U.. AU - Tresoldi, M.. AU - Chierchia, S. L.. AU - Rugarli, C.. PY - 1996. Y1 - 1996. N2 - Interleukin-2 (IL-2) is a cytokine with proven activity against metastatic renal cell carcinoma (RCC) and malignant melanoma (MM). The intravenous administration of high-dose IL-2 is limited by important cardiovascular side effects such as hypotension, fluid retention, arrhythmias, and myocardial chemia, which often cause dose reduction and/or treatment withdrawal. The occurrence of these toxic events is not predicted by routine pretreatment examinations. The aim of the present study was to test the reliability of serial echocardiography in predicting subsequent cardiac adverse effects in patients ...
The LV and right ventricular (RV) diastolic function was evaluated in 65 patients with degree II arterial hypertension (AH) (WHO/IAH?, mean age 50.6±1.2 years) using Doppler echoCG at rest and in cold stress. The study demonstrated a possibility for asynchronous development of ventricular diastolic dysfunction with its prevalence of 14.7% for LV and 23.5% for RV. Disorders of both LV and RV diastolic function were revealed in 26.5% of patients. The cold test considerably more frequently induced impairment of RV than LV diastolic function. Both LV and RV diastolic dysfunction can be sufficiently well corrected with lisinopril, nebivolol and amlodipine ...
The main finding of the present study is that IR is associated with LVDD independent of overt diabetes. These finding persist after adjustment for CAD, hypertension, age, sex, history of previous myocardial infarction, history of previous coronary angioplasty, EF and glycaemic control. To our knowledge, this is the first study that demonstrated an association in a population of patients without a history of diabetes focusing on the published current guidelines for the diagnosis of LVDD.. Furthermore, our date confirm the observations that T2DM is associated with LVDD [9], which is considered a precursor of diabetic cardiomyopathy. In addition, we were able to extend the findings in previous studies showing the association between LVDD and IGT.. These findings are in line with a limited number of studies that assessed the relationship between prediabetes and LVDD mainly in population based studies [11]. Nevertheless, there are some concerns about methodological issues involving the identification ...
Left ventricular diastolic function plays an important role in cardiac physiology. Lusitropy, the ability of the cardiac myocytes to relax, is affected by both biochemical events within the myocyte and biomechanical events in the left ventricle. β-Adrenergic stimulation alters diastole by enhancing the phosphorylation of phospholamban, a substrate within the myocyte that increases the uptake of calcium ions into the sarcoplasmic reticulum, increasing the rate of relaxation. Troponin I, a regulatory protein involved in the coupling of excitation to contraction, is vital to maintaining the diastolic state; depletion of troponin I can produce diastolic dysfunction. Other biochemical events, such as defects in the voltage-sensitive release mechanism or in inositol triphosphate calcium release channels, have also been implicated in altering diastolic tone. Extracellular collagen determines myocardial stiffness; impaired glucose tolerance can induce an increase in collagen cross-linking and lead to ...
The participants were randomly assigned to receive the usual primary care (control condition; n = 677) or screening with BNP testing (n = 697) and followed up until December 2011 (mean follow-up, 4.2 [SD, 1.2] years). Intervention-group participants, with BNP levels of 50 pg/mL Sirtinol clinical trial or higher, underwent. echocardiography and collaborative care between their primary care physician and specialist cardiovascular service. The primary end point was prevalence of asymptomatic systolic LV dysfunction, with or without newly diagnosed heart failure. Due to the slower than expected recruitment rates, the investigators extended the study period and redefined the primary endpoint to include significant LV diastolic dysfunction as determined by a ratio of mitral peak velocity. of early filling (E) to early diastolic mitral annular velocity (E) greater than 15.It is important to note that this change did not alter the validity of the study design. Secondary end points included emergency ...
This study, conducted in a cohort of never-treated and well-characterized hypertensive patients, showed that the worsening of glucose tolerance was associated with an impairment of left ventricular diastolic function. The main finding of this study is that 1-h postload plasma glucose in NGT subjects is associated with left ventricular diastolic dysfunction. This result persists after adjustment for all significant covariates reported in Table 3. Of interest and clinically relevant, NGT ≥155 subjects had significantly worse diastolic function compared with NGT,155 subjects and similar compared with IGT and T2D patients. To our knowledge, this is the first study that demonstrates this association, confirming the usefulness of early diagnosis in the stratification of overall cardiovascular risk; in addition, it highlights the links between early alterations of glucose tolerance and early alterations in cardiac function.. There is a consistent body of evidences demonstrating the association ...
Abstract Cardiovascular autonomic neuropathy (CAN) is one of the most serious complications of diabetes and has been weakly linked with left ventricular (LV) diastolic dysfunction. Previous studies that explored this association either suffer from inadequate definition of CAN or have mainly used conventional Doppler or nuclear techniques to investigate LV diastolic function. Tissue Doppler imaging (TDI) has evolved as a new quantitative tool for the assessment of cardiac systolic function, diastolic function, and the hemodynamics of LV filling. We sought to investigate conventional and TDI derived indices of LV systolic and diastolic function in type 1 patients with and without CAN, and also in normal control subjects. Our findings suggest that the presence of CAN seems to have an additive effect on LV diastolic dysfunction in type 1 diabetes.. ...
Background: Patients with coronary microvascular dysfunction (CMD) often have diastolic dysfunction, representing an important therapeutic target. Ranolazine-a late sodium current inhibitor-improves diastolic function in animal models and subjects with obstructive coronary artery disease (CAD). Hypothesis: We hypothesized that ranolazine would beneficially alter diastolic function in CMD. Methods: To test this hypothesis, we performed retrospective tissue tracking analysis to evaluate systolic/diastolic strain, using cardiac magnetic resonance imaging cine images acquired in a recently completed, randomized, double-blind, placebo-controlled, crossover trial of short-term ranolazine in subjects with CMD and from 43 healthy reference controls. Results: Diastolic strain rate was impaired in CMD vs controls (circumferential diastolic strain rate: 99.9% ± 2.5%/s vs 120.1% ± 4.0%/s, P = 0.0003; radial diastolic strain rate: −199.5% ± 5.5%/s vs −243.1% ± 9.6%/s, P = 0.0008, case vs control). ...
Table 1 illustrates associations between risk factors with diastolic LV function. End diastolic volume (EDV) modified the relationship of gender and PFR. Mean PFR was therefore analyzed across quintiles of EDV and was found to be higher in females 386.35, [95%CI 382.53 to 390.17] compared to males 359.11 ml/s [95%CI 355.05 to 363.17] (Fig 1). Comapred to non-smokers smokers had lower peak filling rates. Compared to Whites, Hispanics were at a higher risk for diastolic dysfunction, Chinese ethnicity showed a relative protective effect after adjusting for all other risk factors. ...
The division of diastolic dysfunction into three classes implies progression from one class to the next. However, to our knowledge, no previous studies have shown such progression to occur and the factors that influence this progression. In the current study, over 3.6 years, diastolic function remained stable in approximately half of the study population. Of the remainder, diastolic function deteriorated in 27% and improved in 21%. This suggests that in about half of these patients, diastolic function does not progress with time and the division into stages or classes of severity may erroneously suggest that progression naturally occurs from one stage to the next. From the multivariate model of the predictors of all-cause mortality, progression of diastolic dysfunction, age, clinical evidence of heart failure at the time of echocardiogram, the presence of a major co-morbidity, transmitral flow and diuretic use were each independently associated with outcome. Importantly, the subgroup of patients ...
2010 (English)In: Journal of the American Society of Echocardiography, ISSN 0894-7317, E-ISSN 1097-6795, Vol. 23, no 2, 162-163 p.Article in journal (Other academic) Published ...
[Dyspnea and normal systolic function].: 30-50% of patients presenting with symptoms of congestive heart failure exhibit a near normal left ventricular systolic
To our knowledge, this is the first study comparing the contractile function in SHR with its normotensive control WKY using PV methodology. In addition, we assessed diastolic function in these animals by using this technique and two others. PV analysis is a useful approach for examining the intact chamber function independently of load.. Diastolic dysfunction was expected in the SHR, based on the increased wall thickness and fibrosis and the impaired relaxation and augmented chamber stiffness reported by others using this model.1,4,29 These alterations were detected in vivo in our study, based on the increased EDPVR, the restrictive pattern of the Doppler E/A ratio, and the leftward shift in the PV relation observed in the ex vivo experiments. Impaired relaxation was also detected in our hypertensive animals, as reflected by the prolonged τ and the fact that for a given maximal velocity of contraction (+dP/dt), maximal velocity of relaxation (−dP/dt) was decreased. Relaxation, an active ...
Insufficient data describe the relationship of hemodynamic parameters to left ventricular (LV) diastolic flow propagation velocity (Vp) measured using color M-mode Doppler echocardiography.. Go to the Article ...
Fig. 21. The varying severity of restriction to diastolic ventricular filling is shown with lines to indicate the ventricular diastolic pressure elevations and their timing in diastole. In mild form, the pressure increase is during atrial contraction (AC) at end diastole (line #1). As restriction gets worse, the pre-a wave pressure starts to rise gradually and earlier and earlier in diastole. This progression is shown as four successive lines (lines #2). When severe, it may be total during mid and late diastole, restricting flow into the RV beginning with the slow filling phase (SF). There will be very rapid inflow only during early diastole or the rapid filling phase (RF) followed by a rapid rise in pressure with no further flow producing the classic dip and plateau or the square root pattern (line #3). This is typical for chronic constrictive pericarditis. If the restriction is severe and involves also the RF phase, the pressures rise quickly in the RV in early diastole limiting inflow ...
While diastolic heart failure refers to the clinical syndrome of heart failure in the setting of a normal ejection fraction. Diagnosis, prognosis. Diastolic dysfunction. Quence of diastolic dysfunction. Heart diastolic dysfunction diastolic heart failure, a major cause of morbidity and mortality, is defined as symptoms of heart failure in a patient with preserved left ventricular function. Recommendations for the Evaluation of Left Ventricular. Patients with diastolic heart failure, as well as those with diastolic dysfunction and little or no congestion, exhibit exercise intolerance for two principal reasons. New concepts in diastolic dysfunction and diastolic heart failure. Diastolic Function by Echocardiography. ...
PubMed journal article: Right ventricular diastolic function 15 to 35 years after repair of tetralogy of Fallot. Restrictive physiology predicts superior exercise performance. Download Prime PubMed App to iPhone, iPad, or Android
Urgency. In patients with sick sinus syndrome (SSS), symptoms of heart failure result from pronounced bradycardia and the failure to increase sinus rhythm adequately during exercise. Aim. Evaluating parameters of LV diastolic function in patients with SSS before and after the surgery of electric cardiostimulator (ECS) implantation. Materials and methods. Study enrolled 37 patients with SSS who were randomized to three groups: group 1, patients with type 1 LV diastolic dysfunction (DD); group 2, patients with type 2 LV DD; group 3, patients without LV DD. EchoCG was performed before and after ECS implantation. Results. The ECS implantation improved LV diastolic function in patients with type LV DD. The ECS implantation did not influence the LV diastolic function in patients with SS in advanced type 2 LV DD or with normal LV diastolic function ...
Clinical trial for NIDDM , Teneligliptin on the Progressive Left Ventricular Diastolic Dysfunction With Type 2 Diabetes Mellitus Study
TY - JOUR. T1 - Effect of ischemic arrest on left ventricular relaxation, diastolic stiffness and contractility. AU - Schaff, Hartzell V. AU - Flaherty, J. T.. AU - Fredricksen, J. W.. PY - 1977. Y1 - 1977. N2 - The effect of ischemic arrest (IA) on ventricular relaxation and the diastolic pressure-volume (P/V) relationship was studied in 17 isolated, perfused, isovolumic feline hearts. During one hour of IA, nine hearts were maintained at normothermia (NIA) and eight were cooled to 27°C hypothermia (HIA). Maximum dP/dt was used as an index of contractility. P/V curves were inscribed by constant volume infusion into an intraventricular balloon and plotted according to the equation Pd = βe (dVd), where Pd = end diastolic pressure; Vd = end diastolic volume; (stiffnes constant) = slope of in Pvs Vd; and β = InP intercept at Vd = 0. To normalize for initial cavity size, curves were replotted as Pd vs (Vd-Vo)/V0, where Vo = volume at Pd of 10 mm Hg. Left ventricular relaxation was assessed by ...
Patients with hypertension and left ventricular (LV) hypertrophy commonly have impaired diastolic filling. However, it remains unknown whether changes in LV diastolic filling variables are associated with cardiovascular morbidity and mortality. In this study, 778 patients with hypertension with electrocardiographic LV hypertrophy who underwent echocardiography at baseline and annually thereafter during randomized losartan- or atenolol-based antihypertensive treatment were followed for a mean of 4.6 years. The composite cardiovascular end point was the first occurrence of fatal or nonfatal myocardial infarction, fatal or nonfatal stroke, and cardiovascular mortality. Antihypertensive therapy resulted in an increase in the prevalence of normal transmitral flow pattern from 28% to 46% of patients. Although antihypertensive treatment often resulted in a marked increase in the prevalence of normal mitral valve flow pattern, this was not associated with reduced cardiovascular morbidity and mortality ...
0068] In act 48, a value for a parameter is output. This value is another example of the output of act 44. The value is derived from the pressure and/or volume information, either instantaneous or as a function of time. For example, beat-to-beat parameters, such as stroke volume (SV), contractility (e.g., ejection fraction, SV/EDV, and/or dp/dt Max), preload (EDV or EDP), afterload (aortic and ventricular pressure), compliance (dV/dP), ventricular stiffness (inverse of compliance), and/or elastance (dP/dV), are calculated. As another example, parameters derived from ESPVR and EDPVR, such as PVA Pressure-volume area and/or PE Potential energy, are calculated. In yet another example, processed parameters, such as ESPVR end-systolic pressure-volume relationship, EDPVR end-diastolic pressure-volume relationship, PRSW Preload-recruitable stroke work, DPdtmax vs Ved dPdt max against end-diastolic volume relationship, and/or Emax maximal elastance (computed from the time-varying elastance data), are ...
BACKGROUND: Obesity is characterized by impaired cardiac energetics, which may play a role in the development of diastolic dysfunction and inappropriate shortness of breath. We assessed whether, in obesity, derangement of energetics and diastolic function is further altered during acute cardiac stress. METHODS AND RESULTS: Normal-weight (body mass index, 22±2 kg/m(2); n=9-17) and obese (body mass index, 39±7 kg/m(2); n=17-46) subjects underwent assessment of diastolic left ventricular function (cine magnetic resonance imaging volume-time curve analysis) and cardiac energetics (phosphocreatine/ATP ratio; (31)P-magnetic resonance spectroscopy) at rest and during dobutamine stress (heart rate increase, 65±22% and 69±14%, respectively; P=0.61). At rest, obesity was associated with a 22% lower peak filling rate (P|0.001) and a 15% lower phosphocreatine/ATP ratio (1.73±0.40 versus 2.03±0.28; P=0.048). Peak filling rate correlated with fat mass, left ventricular mass, leptin, waist-to-hip ratio, and
Definition of pseudonormalization. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
We sought to evaluate the relationship between plasma cytokine levels (sCD14, tumor necrosis factor [TNF]-alpha, and interleukin [IL]-6) and tissue Doppler derived indices of left ventricular systolic and diastolic function in patients with newly diagnosed heart failure. We enrolled 101 consecutive patients (mean age 65+/-13 years) with newly diagnosed heart failure who were hospitalized in our institute. Echocardiographic assessment was performed in all patients during the third day of their initial hospitalization. The pulsed tissue Doppler imaging (TDI) of the systolic and diastolic function of mitral annulus was characterized by the systolic wave Smv, and the diastolic waves: Emv and Amv. Left atrial kinetic energy (LAKE), an index of left atrial function, was calculated using the equation 1/2 x LASV x 1.06 x Amv(2); where LASV is left atrial systolic volume. Furthermore the ratio E/Emv and the flow propagation velocity were also calculated; where E is the rapid mitral filling wave, detected ...
I have bicuspid aortic valve mild AR mildAs with mild lv diastolic dysfunction. I am taking embeta xr 75 mg in a day for arrythemia. Please give me suggestions.
Citation counts are provided from Web of Science and CrossRef. The counts may vary by service, and are reliant on the availability of their data. Counts will update daily once available.. ...
We investigated the impact of lowering blood pressure (BP) with azelnidipine, a newly developed calcium channel blocker, generation on the left ventricular (LV) diastolic function and LV filling pressure by assessing non-invasive indices derived from echo Doppler study. This study evaluated 232 hypertensive patients with diastolic dysfunction. This study had two groups: (1) in which azelnidipine was administered to patients as a first-line therapy, and (2) in which amlodipine was converted to azelnidipine. Early diastolic mitral annulus velocity (e, cm s(-1)), the ratio of peak E velocity to e velocity (E/e ratio) and level of brain natriuretic peptide (BNP) were measured before and, an average of, 8 months after azelnidipine treatment ...
Young ischemic stroke (YIS) refers to ischemic stroke occurring in patients aged 45 or under and its incidence is increasing annually (14). The reason is probably its characteristics of early onset, early disability and high recurrence. At present, YIS accounts for an estimated 5-10% of all cases of CI and the most common pathogenetic origin of the disease is atherosclerosis caused by hypertension (21). The pathogenic effect of hypertension has been indicated to be directly correlated with its severity and duration, which indicates a connection between hypertension and an increased risk of YIS (22).. Young patients pay insufficient attention to blood pressure and frequently remain untreated (23). This long-term elevation of peripheral blood pressure increases cardiac after-loading, while increased peripheral vasoconstriction tension and retention of sodium and water increase myocardial oxygen consumption, deteriorate myocardial compliance and augment ventricular end-diastolic pressure (24). As a ...
Background: Systolic heart failure (HF) is frequently accompanied by diastolic dysfunction and sleep-disordered breathing (SDB). We evaluated, whether auto-servo ventilation (ASV, BiPAP ASV, Philips Respironics) improves echocardiographic measures of diastolic function in patients with systolic HF and SDB.. Methods: 32 patients with stable systolic HF and concomitant diastolic dysfunction (age 66±9y, LVEF 30±7%, NYHA class II 72%) and SDB (AHI 48±19/h, 53% OSA) were randomized to either ASV (n=19) or optimal medical treatment alone (control, n=13). Polysomnography and echocardiography was performed at baseline and after 12 weeks.. Results: AHI improved significantly more in the ASV group compared to the control group (-38±18 vs. -0.2±13.2/h, P,0.001). At baseline, 24 (75%) patients had impaired left ventricular relaxation, and 8 (25%) had a pseudonormalized filling pattern. At the 12-weeks control visit, diastolic function as assessed by the isovolumetric relaxation time (IVRT, -10.3±26.1 ...
Left ventricular diastolic dysfunction is highly prevalent, tends to worsen over time, and is associated with advancing age. Worsening diastolic function can be detected even in apparently healthy persons, the conclusion by the authors of a recent article published in JAMA.. Randomly selected participants 45 years or older (N = 2042) underwent clinical evaluation, medical record abstraction, and echocardiography (examination 1 [1997-2000]). Diastolic left ventricular function was graded as normal, mild, moderate, or severe by validated Doppler techniques. After 4 years, participants were invited to return for examination 2 (2001-2004). The cohort of participants returning for examination 2 (n = 1402 of 1960 surviving [72%]) then underwent follow-up for ascertainment of new-onset heart failure (2004-2010).. During the 4 years between examinations, diastolic dysfunction prevalence increased from 23.8% to 39.2%:. ...
Nonalcoholic fatty liver illness (NAFLD) can be a issue [[http://​robertfkennedyjr.net/​form-two-diabetes-induce-and-remedy/​,http://​www.diettalk.com]] ​ wherein the liver has as well substantially unwanted fat. Commonly it can be not deadly, but it surely may become infected. In nondiabetics it has been related to a heart disorder regarded as left ventricular diastolic dysfunction. The remaining ventricle on the heart pumps blood coming from the lungs via the still left atrium. Blood pumped through the remaining ventricle travels in the aorta, a big artery, from where by it travels throughout the body. In left ventricular diastolic dysfunction,​ LVDD, the left ventricle does not fill thoroughly involving beats. This may trigger fluid to again up in the still left atrium together with the lungs. This problem is known as heart failure. Investigators at College and Azienda Ospedaliera Universitaria Integrata of Verona and other investigate centers in Italy, executed a examine to ...
In patients with type 1 diabetes mellitus (T1DM) imaging studies have demonstrated an increased prevalence of left ventricular diastolic dysfunction and increased left ventricular mass (LVM) unrelated to arterial hypertension and ischemic heart disease. The aim of our study was to identify potential predictors of early subclinical changes in cardiac chamber size and function in such patients. Sixty-one middle-aged asymptomatic normotensive patients with T1DM were included in the study. Conventional and tissue Doppler echocardiography was performed and fasting serum levels of glucose, glycated hemoglobin (HbA1c), lipids, and creatinine were measured. We found moderate bivariate correlations of body mass index (BMI) with left atrial volume (r = 0.47, p , 0.01), LVM (r = 0.42, p , 0.01), left ventricular relative wall thickness (r = 0.32, p = 0.01), and all observed parameters of diastolic function of both ventricles. The five-year average value of HbA1c weakly correlated with the Doppler index of ...
Clinical symptoms and signs, supporting chest radiography, typical clinical response to diuretics with or without elevated left ventricular filling pressure, or low cardiac index.. ‡- Left ventricular ejection fraction of 50 percent or more within 72 hours of event.. §- Abnormal left ventricular relaxation or filling or distensibility indices on catheterization.. References:. ...
Diastolic dysfunction, which is the key pathophysiological mechanism in HFpEF, is also considered a potential pathophysiological factor of HFrEF.23 In the present study, EDPVR normalization was significantly associated with higher CO regardless of EF in high‐EDP patients. Furthermore, there were no differences in the degree of change in CO among EF groups, suggesting that diastolic dysfunction exerts a similar hemodynamic effect regardless of EF. Although several previous articles have mentioned the importance of diastolic dysfunction in HFrEF,24, 25 this study is the first to demonstrate its quantitative impact on CO. This finding highlights the profound impact of diastolic dysfunction on hemodynamics in patients with HFrEF.. Previous studies26, 27 used the same single‐point EDPVR estimation method as we used in the current study. In those studies, α and β were defined as the diastolic curve fitting constant and stiffness constant, respectively. Those studies reported that the both α and ...
Diastolic dysfunction is frequently seen after myocardial infarction and is characterized by a disproportionate increase in filling pressure during exercise to maintain stroke volume. We hypothesized that sildenafil would reduce filling pressure during exercise in patients with diastolic dysfunction after myocardial infarction ...
We read the article of Betcher et al. [1] regarding the feasibility of measuring stroke volume and diastolic function parameters with transthoracic echocardiography (TTE) in the emergency department (ED). While this is clearly stated as a feasibility study, we are honestly questioning the real utility of taking all these measurements, since nearly all patients can be managed without this information on the trenches, reasoning basic echo findings in context with the history and physician examination, without the need of adding complexity, spending extra time, or exposing patients to technique errors or interpretation mistakes. Mentors and trainees must understand (and thus focus on setting the bases of training accordingly) that a well-performed basic echocardiogram (with the addition of the information provided by lung ultrasound, which provides valuable data when showing the mere presence of B lines and/or pleural effusions, answering a simple clinical question in terms of wet vs. dry lungs ...
Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.
Each heartbeat has a systolic component and a diastolic component. The heart first contracts and pumps blood out of the ventricular chambers (Systolic phase) and then goes through a phase of relaxation which allows blood to refill the ventricles (Diastolic Phase). According to this report, even when the systolic function is normal, diastolic dysfunction (DD) has been associated with an increased risk of death from cardiovascular and other reasons. The researchers in this study attempted to determine if the mortality risk associated with DD was an independent risk factor for increased risk for death in the presence of a normal systolic function. They also set out to determine whether this held true for milder cases of DD as well. The researchers began to understand the clinical relevance of the presence of diastolic dysfunction and degree of DD in patients who had normal ejection fraction who underwent outpatient echocardiography. They used echocardiography since it is one of the most common ...
Here, we show that in vivo Ang-(1-7) protective signaling against DOCA-induced diastolic dysfunction occurs independently of its lowering BP effects and is mediated at the cardiomyocyte level by the activation of molecular pathways involved in Ca2+ handling, hypertrophy, and cell survival. By dissociating the BP effect of Ang-(1-7), we were capable of showing that BP attenuation in TG-DOCA represents a minor component of Ang-(1-7) beneficial effects. In addition, we show that Ang-(1-7) protective signaling occurs even under conditions of moderately high BP because TG-DOCA rats were hypertensive. Altogether, these findings provide the mechanistic input necessary to develop new strategies for clinical use of Ang-(1-7) alone or in combination with other drugs in patients with diastolic heart failure (HF).. Clinical studies have demonstrated the importance of MR antagonists for the prognostic improvement of patients with chronic HF.16,17 Preclinical data have shown strong evidence that Ang-(1-7) ...
Background: Left ventricular diastolic dysfunction (LVDD) is a common abnormality among patients in T2DM. Aims: We aimed to evaluate the feasibility
A system and method for determining indicators of left ventricular function, and for determining the effectiveness of a cardiac therapy are disclosed. The indicators of left ventricular function can include isovolumetric relaxation time and the negative slope of a V wave obtained from measuring changes in left atrial pressure during diastole. The apparatus may include a catheter comprising an inflatable balloon for insertion into the esophagus of an individual, a compressor device for pressurizing the balloon, and a means for sensing and recording pressure changes on the balloon.
Two players must pump a human heart by clicking two buttons in coordination: one acts as the systole movement, the other as the diastole. Pictures indicate what the character is doing, so the players must reproduce the heart rate according to the activity (e.g., running). The heart will receive damage (and eventually die) if the players press their buttons at the same time or if they play the wrong rhythm. When they keep pumping the heart to match the correct heartbeat for a short amount of time, they pass to a new activity. Aim for a high score! Tried in Chrome & Firefox. Best played with headphones ...
Traditionally, heart failure is associated with reduced pumping capacity of the heart. However, deteriorated filling of the heart, known as diastolic dysfunction, has recently been acknowledged as a prominent cause of HF, accounting for nearly 50% of all cases.. Diastolic dysfunction is linked to increased stiffness of the myocardium, and is highly relevant in patients with for instance aortic stenosis, hypertension, diabetes and cardiomyopathies.. There is currently no effective medical treatment for diastolic dysfunction. This suggests that important pathological mechanisms remain unknown. Our primary objective is therefore to identify the key mechanisms underlying diastolic dysfunction.. ...
I clicked here to discover what in the heck diastolic hypertension is and how to treat it. Everyone knows about high blood pressure, and how it can cause a host
A common form of heart trouble called diastolic dysfunction appears to worsen over time and may lead to an increased risk of heart failure, new research shows.
The acute ECG (first one at top) clearly shows the previous MI (Q-waves). The T-waves are upright. Is this pseudonormalization? No. Over weeks to months and certainly years, inverted T-waves of MI normalize as part of the natural history of the ECG in MI (Although, in LV aneurysm, they often remain with shallow invertion). So before this acute event the T-waves were likely upright ...
now, today well be talking about the cardiac cycle. and the cardiac cycle well be discussing in two fashions, and one way we will discussing cardiac cycle while I will be doing different diagrams and in second phase, Well discuss the cardiac cycle Uhhhhh, When I will be presenting the errands during the cardiac cycle Graphically So first of all, ...
Main article: Diastole. During diastole, the ventricular pressure falls from the peak reached at the end of systole. When this ... Diastole has four phases: isovolumetric relaxation, rapid filling, diastasis and atrial contraction. All of these phases can be ... In diastolic heart failure, the volume of blood contained in the ventricles during diastole is lower than it should be, and the ... Mathematics describing the relationship between the ratio of Systole to Diastole in accepted terms of End Systolic Volume to ...
Diastole 05. Systole [1] Ghettoblaster Magazine, June 24, 2015. [2] MusicBox Pete June 29, 2015 "Hawking Introduces Us To Math ...
Energizing diastole. Heart Fail Clin. 2008 Jan;4(1):ix-xiii. Review. PMID 18313619. Baliga RR, Young JB. Never too late to ...
Retrieved December 17, 2014.old-form url Mollusc Specialist Group (1996). "Diastole matafaoi (Mount Matafao Different Snail)". ...
During diastole, the ventricle of heart must remain elastic or compliant enough and have capacity to hold incoming blood to ... Brutsaert, D. L.; Sys, S. U. (1989-10-01). "Relaxation and diastole of the heart". Physiological Reviews. 69 (4): 1228-1315. ...
Both valves are pressed open during the late stages of ventricular diastole; see Wiggers diagram at the P/QRS phase (at right ... Atrial systole lasts approximately 100 ms and ends prior to ventricular systole, as the atrial muscle returns to diastole. The ... Atrial systole occurs late in ventricular diastole and represents the contraction of myocardium of the left and right atria. ... At the start of atrial systole, during ventricular diastole, the ventricles are normally filled to about 70 - 80 percent of ...
"diastole, n." Oxford University Press (Oxford), 1895. Nicolas, Nick. "Greek Unicode Issues: Punctuation Archived November 20, ... lower separation [mark]'), also known as a diastole, was an interpunct developed in late Ancient and Byzantine Greek texts ...
Ventricular systole Cardiac diastole ECG The EKG complex. P=P wave, PR=PR interval, QRS=QRS complex, QT=QT interval, ST=ST ...
Diastole matafaoi.2006 IUCN Red List of Threatened Species. Downloaded on 6 August 2007. v t e. ... The Mount Matafao different snail, scientific name Diastole matafaoi, was a species of air-breathing land snails or semi-slugs ...
Cardiac systole and diastole. During each heartbeat, blood pressure varies between a maximum (systolic) and a minimum ( ...
Atrial systole overlaps the end of the diastole, occurring in the sub-period known as ventricular diastole-late (see cycle ... Cardiac diastole: Both AV valves (tricuspid in the right heart (light-blue), mitral in the left heart (pink)) are open to ... Starting with the Diastole period: the low-volume plateau of "Isovolumic relaxation" stage, followed by a rapid rise and two ... ventricles and atria together relax and expand; blood flows to the heart during ventricular and atrial diastole. ...
... diastole, and the pressures in the left atrium and the left ventricle during ventricular diastole will be equal. The result is ... As the heart rate increases, the amount of time that the ventricle is in diastole and can fill up with blood (called the ... Normally, the mitral valve is about 5 cm2 during diastole. Any decrease in area below 2 cm2 causes mitral stenosis. Early ... In normal cardiac physiology, the mitral valve opens during left ventricular diastole, to allow blood to flow from the left ...
During diastole, the ventricles relax and fill with blood again. The left ventricle receives oxygenated blood from the left ...
Occurs during systole or continuously during both systole and diastole. (Murmurs occurring only during diastole are usually ...
Diastole Hospital Hill, Inc., University of Missouri-Kansas City, 1985. Farnsworth, Robert. Edgar Snow's Journey South of the ...
These two phases are commonly understood as systole and diastole. The rest phase is considered polarized. The resting potential ...
This limits ventricular filling during diastole, which increases end-diastolic volume. This can lead to a variety of cardiac ...
"Volume catheter parallel conductance varies between end-systole and end-diastole". IEEE Trans Biomed Eng. 54 (8): 1480-9. doi: ...
P I = v s y s t o l e − v d i a s t o l e v m e a n {\displaystyle PI={\frac {v_{systole}-v_{diastole}}{v_{mean}}}} Resistance ... Blood velocities in arteries are higher during systole than during diastole. One parameter to quantify this difference is the ...
As the heart rate becomes more robust, and the length of diastole decreases, the Na+/K+-ATPase, which removes the Na+ brought ... This occurs because of the decreased length of diastole with positive chronotropy. With an increased intracellular Ca++ ...
The stage in which water flows into the CV is called diastole. The contraction of the contractile vacuole and the expulsion of ...
In severe aortic regurgitation, additional blood reenters the left ventricle during diastole. This added volume of blood must ...
During cardiac diastole (when the heart chamber gets bigger) the aortic valve closes. Aortic stenosis most commonly is the ... connective tissue disorders such as Marfan syndrome or Ehlers-Danlos lead to imperfect closure of the valve during diastole, ...
A: Single-phase flow with minimal or absent diastole when the penis is flaccid. B: Increased systolic flow and reverse diastole ...
... where td is the time of the start of diastole and P(td) is the blood pressure at the start of diastole. This model is only a ... During diastole there is no blood inflow since the aortic (or pulmonary valve) is closed, so the Windkessel can be solved for P ... An example for the two-element model is shown below, where I(t) is depicted as an input signal during systole and diastole. ... Systole is represented by the sin function, while flow during diastole is zero. s represents the duration of the cardiac cycle ...
This change in repolarization inhibits the heart from relaxing and properly entering diastole. Changes in the ventricular ...
This relaxation of the left ventricle (early ventricular diastole) causes a fall in its pressure. When the pressure in the left ... Since some of the blood that is ejected during systole regurgitates back into the left ventricle during diastole, there is ... S1 is soft because the elevated filling pressures close the mitral valve in diastole.[medical citation needed] Chronic aortic ... is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during ventricular diastole ...
On the other hand, during diastole, the blood volume in the finger is decreased; as a result the PID-controller decreases the ...
Diastole is an - active expansion of the muscle on which the cardiac return depends. This is an addition to Starling's law of ... With experimental evidence on the canine heart, he discovered that atrial diastole is the key force that creates a negative ...
It is widely assumed that reflections are minimal during late diastole and early systole. With this assumption, PWV can be ...
Early diastole is a suction mechanism between the atrial and ventricular chambers. Then, in late ventricular diastole, the two ... Diastole (/daɪˈæstəli/ dy-AST-ə-lee) is the part of the cardiac cycle during which the heart refills with blood after the ... When, in late diastole, the ventricles become fully dilated (understood in imaging as LVEDV and RVEDV), the atria begin to ... During early ventricular diastole, pressure in the two ventricles begins to drop from the peak reached during systole. When ...
Here, we discuss the difference between diastole and systole and the risks of hypertension (high) and hypotension (low) blood ... What are diastole and systole?. Diastole is when the heart muscle relaxes and systole is when the heart muscle contracts. ... The terms diastole and systole refer to when the heart muscles relax and contract. The balance between diastole and systole ... Diastole is when the heart muscle relaxes.. *When the heart relaxes, the chambers of the heart fill with blood, and a persons ...
Definition of electrical diastole. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ...
Species in the genus Diastole include: [1] Diastole bryani H. B. Baker, 1938 Diastole conula (Pease, 1861) Diastole exposita ( ... Diastole futunae H. B. Baker, 1938 Diastole glaucina Baker, 1938 Diastole lamellaxis Baker, 1938 Diastole lauae H. B. Baker, ... 1938 Diastole rurutui H. B. Baker, 1938 Diastole savaii Baker, 1938 Diastole schmeltziana (Mousson, 1865) Diastole simonei ... Thach & F. Huber, 2017 (taxon inquirendum) Diastole subcarinata Solem, 1959 Diastole tenuistriata Preece, 1995 Diastole tongana ...
diastole definition: the usual rhythmic dilatation of the heart, esp. of the ventricles, following each contraction (systole), ... Origin of diastole. Greek diastolē dilation, separation from diastellein to expand dia- apart ; see dia- . stellein to place, ... diastole. di·as·to·le. the usual rhythmic dilatation of the heart, esp. of the ventricles, following each contraction (systole ... diastole. noun. * Physiology The normal rhythmically occurring relaxation and dilatation of the heart chambers, especially the ...
... (pronounced di-as´to-le, rhymes with potentially) is the period of time when the heart relaxes after contraction. ... Ventricular diastole is the period during which the ventricles are relaxing, while atrial diastole is the period during which ... You can always remember which is which (diastole and systole) because the Greek word diastole meaning "dilation" shares the ... Diastole (pronounced di-as´to-le, rhymes with "potentially") is the period of time when the heart relaxes after contraction. ...
Synonyms for systole and diastole at Thesaurus.com with free online thesaurus, antonyms, and definitions. Dictionary and Word ...
... and possibly also with a relaxation that is incomplete and still ongoing at end-diastole. Both decreased compliance and delayed ...
Evidenced Based Weaning From Ventilator - Free download as PDF File (.pdf), Text File (.txt) or read online for free. Evidenced Based Weaning From Ventilator
Passive Stiffness of Myocardium From Congenital Heart Disease and Implications for Diastole. Rajiv R. Chaturvedi, Todd Herron, ... Passive Stiffness of Myocardium From Congenital Heart Disease and Implications for Diastole ... Passive Stiffness of Myocardium From Congenital Heart Disease and Implications for Diastole ... Passive Stiffness of Myocardium From Congenital Heart Disease and Implications for Diastole ...
Image #1/5: Breathtaking lakeviews from this mountaintop B&B. 7 minutes from the Baseball Hall of Fame, 15 minutes from Glimmerglass Opera and Dreams Park. J...
A nutrient-rich, low-processed diet can help bring your blood pressure closer to normal or even within a wholesome range. You will begin to see a difference usually in just a few months, but consistency and continuous effort are the key. Foods, including fresh vegetables and fruits, lean proteins and some healthy fats, help reduce inflammation andPrevent nutrient deficiencies, which are two of the leading causes of high blood pressure.. * Wish me good luck! High BP story in my family. I knew it and quickly became the finest and most fit in my family forever, pushing 50, just went to doc ole and my bp was 170 + / 90+, obviously wanted me on BP MED. heck no. So I did some research ... and I found cayenne pepper and apple cider vinegar mother version! Im not kidding, the wedding, I saw doc, by wed nite, I started to take 1/4 teaspoon of cayenne pepper that nite, I also started to take spoon ACV 2 soup soup tonight.. * Arterial hypertension, also known as high blood pressure, is a serious and ...
Smart meters, power lines, electrical appliances and even electrical outlets throughout your home are damaging sources of radio and magnetic fields that can cause you continuous damage. I found that the Stetzerizer filters can block a significant source of electromotive force found in every home at the electrical outlets. http//www.stetzerizer-us.com/ Grounding mats are reputed to help reduce blood pressure, as electrons from the earth can increase the potential zeta from your red blood cells, forcing them to repel each other.. * The benefits of beetroot cover a variety of elements, from the maintenance of a healthy libido to the detoxification of blood. Its juice, called beet juice, has been used since the Middle Ages to treat a number of conditions. However, just a popular cure is not - beet juice has been the subject of extensive scientific research for its health benefits, including its ability to lower blood pressure.. * My favorite supplement is one that contains the three fat-soluble ...
Lagrangian strains in cardiac and liber-sheet coordinates were computed at end of early filling and end diastole with filling ... The scope of the current project is to perform detailed studies of cardiac strain, particularly during diastole. There exist ... This reveals transmural strain inhomogeneities during diastole in the ovine heart.. Place, publisher, year, edition, pages ... Spatial and Temporal Inhomogeneity of Left Ventricular Myocardial Transmural Strains During Diastole. Kindberg, Katarina ...
During diastole, none of the signals related to the OFF state of the thick filament are significantly affected by these ... Inotropic interventions do not change the resting state of myosin motors during cardiac diastole ... show that myosin motors fully return to their OFF state during diastole independently of inotropic interventions. ...
Illustration of Heart Anatomy of the Heart The Cardiac Cycle Diastole Ventricular Relaxation and Filling Systole Ventricular ... Heart Anatomy of the Heart The Cardiac Cycle Diastole Ventricular Relaxation and Filling Systole Ventricular Contraction and ... Vector - Heart Anatomy of the Heart The Cardiac Cycle Diastole Ventricular Relaxation and Filling Systole Ventricular ...
Here we perform 3D tractography of the human heart \(in\) \(vivo\) at both end diastole and end systole. We show that fiber ... Diffusion MRI tractography of the human heart \(in\) \(vivo\) at end-diastole and end-systole. Journal of Cardiovascular ... Diffusion MRI Tractography of the Human Heart \(In\) \(Vivo\) at End-Diastole and End-Systole. ...
Diastole. The relaxation phase of the heart muscle.. This phase takes place between two contractions and during it the heart is ...
end-diastole/diastolic. ES. end-systole/systolic. ES-GLS. end-systolic global longitudinal strain. ES-SLS. end-systolic ... How to Define End-Diastole and End-Systole? Message Subject (Your Name) has forwarded a page to you from JACC: Cardiovascular ... Surrogate Parameters Used to Define Timing of End-Diastole. (A) Mean error (considering the sign) ± SD; (B) mean absolute error ... The frame after end-diastole (ED), marked by mitral valve closure (MVC), is often considered as the beginning of a new cardiac ...
This study is designed to assess whether the ratio of transmitral E-wave velocity (E) to early diastole mitral velocity (Ea) is ... Ratio of transmitral E-wave velocity to early diastole mitral annulus velocity with cardiovascular and renal outcomes in ...
Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: time for a redefinition ... Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: time for a redefinition ...
... and diastole (AUC: 0.95 and 0.94). There were no significant differences in the AUCs between systole and diastole (p values , ... and diastole (AUC: 0.95 and 0.94). There were no significant differences in the AUCs between systole and diastole (p values , ... Methods Thirty-five patients underwent 3D-perfusion CMR with data acquired at both end-systole and mid-diastole. MBF and ... Estimates of MBF are significantly different for systole and diastole at stress but diagnostic accuracy to detect CAD is high ...
Intensity ratio of I1,1 over I1,0 (I1,1/I1,0) during the diastole at different SL. Black, 1.96 µm; gray, 2.11 µm; white, 2.22 ... During diastole, none of the signals related to the OFF state of the thick filament are significantly affected by these ... 1 B and Table 1). The corresponding effects on the x-ray diffraction pattern of the trabecula in diastole are shown in Fig. 8, ... X-ray data in diastole with ISO have been collected at all three SLs used for the preceding test on the SL dependence of the ...
An X-ray diffraction study on heart muscle during diastole. Research Project ...
Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of ... Download PDF Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in ... Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of ...
What is diastole and how to assess it? Impaired left ventricular systolic function. Luers C., Maisch B. ... With respect to recent guidelines and recommendations, this review summarizes the physiology and pathophysiology of diastole, ...
Define systole, diastole, and list the ranges of excellent,... ... diastole. Define systole, diastole, and list the ranges of ...
This article requires a subscription or purchase to view the full text. If you are a subscriber or member, click the login link or the subscribe link in the top menu above to access this article.. ...
At each time point, as indicated by the vertical line in early diastole (Fig. 1, top left), the velocity profile across the ... With regard to the MVG in diastole, Palka et al. (13)have recently documented that peak diastolic MVG was useful in ... The MVG forms a steep negative peak in early diastole, corresponding to the peak rate of wall thinning. However, peak negative ... Peak negative MVG in early diastole demonstrated minimal overlap between the normal and the abnormal (HHD and DCM) as compared ...
... *J. V. Tyberg, W. J. Keon, E. H. Sonnenblick, C. W. Urschel ...
  • Estimates of MBF are significantly different for systole and diastole at stress but diagnostic accuracy to detect CAD is high for both cardiac phases. (uzh.ch)
  • List both the systole and diastole. (coursehero.com)
  • Flow was seen through the defect during both systole and diastole excluding the possibility of tricuspid regurgitation artifact. (freethesaurus.com)
  • Reflections of a Grady Doctor: Systole and Diastole. (gradydoctor.com)
  • So today, I was just thinking about how work-life balance is a lot like systole and diastole. (gradydoctor.com)
  • What Is the Difference Between Systole and Diastole? (reference.com)
  • The attractive aspect of this work is that it provides a unifying analysis of untwist and filling, linking systole and diastole. (onlinejacc.org)
  • Tsuiki, K & Ritman, EL 1980, ' Direct Evidence that Left Ventricular Myocardium Is Incompressible Throughout Systole and Diastole ', The Tohoku Journal of Experimental Medicine , vol. 132, no. 1, pp. 119-120. (elsevier.com)
  • The heart cycle consists of a systole and diastole of both the atria and ventricles. (encyclopedia.com)
  • The entire left ventricle was covered in both systole and diastole with a total of 12 slices with a spatial resolution of 2.2×2.2x6mm 3 . (biomedcentral.com)
  • Data across the entire left ventricle were successfully acquired in both systole and diastole. (biomedcentral.com)
  • Transmural course of helix angle for basal, mid, apical region in systole and diastole (A). Slope of a linear fit model for helix angle change from endo- to epicardium (B) and corresponding helix angle range (C). Transmural course of transverse angles β with mean ± one standard deviation (D). (biomedcentral.com)
  • OBJECTIVE To complement the ISO 5840 standards concerning the duration of left ventricular systole and diastole as a function of changes in heart rates according to in vivo studies from the physiologic literature review. (semanticscholar.org)
  • Diastole (/daɪˈæstəli/ dy-AST-ə-lee) is the part of the cardiac cycle during which the heart refills with blood after the emptying done during systole (contraction). (wikipedia.org)
  • At the beginning of the cardiac cycle, all four chambers of the heart, two atria, and two ventricles are synchronously approaching relaxation and dilation, or diastole. (wikipedia.org)
  • The systole is not altered in length, but the diastole is very much prolonged, and since this is the period not only of cardiac rest but also of cardiac "feeding" - the coronary vessels being compressed and occluded during systole - the result is greatly to benefit the nutrition of the cardiac muscle. (yourdictionary.com)
  • Later in its action, the drug depresses the intra-cardiac motor ganglia, causing prolongation of diastole and finally arrest of the heart in dilatation. (yourdictionary.com)
  • Lagrangian strains in cardiac and liber-sheet coordinates were computed at end of early filling and end diastole with filling onset as reference at three transmural depths. (diva-portal.org)
  • The scope of the current project is to perform detailed studies of cardiac strain, particularly during diastole. (diva-portal.org)
  • Heart Anatomy Of The Heart The Cardiac Cycle Diastole Ventricular. (123rf.com)
  • The frame after end-diastole (ED), marked by mitral valve closure (MVC), is often considered as the beginning of a new cardiac cycle, and aortic valve closure (AVC) is used to describe the end of systole (ES). (onlinejacc.org)
  • Diastole / d aɪ ˈ æ s t ə l iː / is the part of the cardiac cycle during which the heart refills with blood after the emptying done during systole (contraction). (orange.com)
  • Cardiac cycle 5 - Atrial diastole ventricular systole standard. (comunidades.net)
  • Diastole - Wikipedia https://en.wikipedia.org/wiki/Diastole Diastole /daɪˈæstəliː/ is the part of the cardiac cycle when the heart refills with blood following systole (contraction). (comunidades.net)
  • Diastole is the stage of the cardiac cycle associated with refilling the heart with blood. (picmonic.com)
  • Intuitively, it is well recognized that sarcomeric relaxation is an active process because skeletal muscle goes into contracture (rigor mortis) rather than relaxation when metabolism stops.Abundant evidence exists that ventricular diastole is also an active process [8,9], because adenosine triphosphate (ATP) is required for the dissociation of actin and myosin in the cardiac myocyte [10-12]. (bioenergylifescience.com)
  • As the ventricles begin to relax, the mitral and tricuspid valves open again, and the completed cycle returns to ventricular diastole and a new "Start" of the cardiac cycle. (wikipedia.org)
  • In this abstract we will investigate the feasibility of dual phase cardiac whole heart MRI to obtain Coronary Magnetic Resonance Angiography (CMRA) at end-systole and mid-diastole in children with Congenital Heart Diseases (CHD). (ismrm.org)
  • The objective of this work was to obtain and make available cardiac DTI data of the in-vivo human heart with full cardiac coverage in both peak systole and mid diastole including correction for myocardial strain. (biomedcentral.com)
  • When pressure in the left ventricle falls below that in the left atrium, the mitral valve opens due to a negative pressure differential (suction) between the two chambers, causing blood in the atrium (accumulated during atrial diastole) to flow into the ventricle (see graphic at top). (wikipedia.org)
  • Our analysis of events in the left atrium and ventricle, and the aorta begins at the far left of Figure 14-25 with the events of mid- diastole to late diastole . (78stepshealth.us)
  • The aim of this study was to examine the difference in the myocardial volume between end-diastole and end-systole in 24 human volunteers, using steady-state free precession gradient-echo cine imaging of both long- and short-axis views of the left ventricle and a newly developed three-dimensional (3D) analysis method. (umn.edu)
  • The pulmonary valve is between the right ventricle and pulmonary artery, and it is closed during diastole. (picmonic.com)
  • then, near the end of ventricular diastole -late , the two atria begin to contract ( atrial systole ), and each atrium pumps blood into the ventricle 'below' it. (wikipedia.org)
  • The aortic valve open to let the blood out of the left ventricle and into the aorta (the main vessel of the body) during systole (when the ventricle contracts) and closes in diastole to prevent regurgitation of the blood from the aorta back into the left ventricle. (healthtap.com)
  • The passive properties of the left ventricle are most accurately measured during the diastasis and atrial contraction phases of diastole. (aacnjournals.org)
  • AUTHORS' SYNOPSIS: A new technique has been developed to investigate in vivo the mechanical properties of the left ventricle during both diastole and systole. (elsevier.com)
  • The Ca2+ cycle is generally divided into two periods: systole, when the ventricular myocardium contracts and ejects the contents of the ventricle, and diastole, where the ventricular muscle relaxes and the chamber refills. (edu.au)
  • A prolonged time constant is associated with a delayed myocardial relaxation, and possibly also with a relaxation that is incomplete and still ongoing at end-diastole. (bmj.com)
  • We sought to assess the clinical significance of peak negative myocardial velocity gradient (MVG) in early diastole as a noninvasive indicator of left ventricular (LV) diastolic function. (onlinejacc.org)
  • Systolic myocardial contraction may produce changes in coronary resistance and capacitance that persist throughout a normal diastole. (elsevier.com)
  • With the 3D analysis method, no significant variance in the myocardial volume was found (mean difference=0.1%±9.1%, p=0.88) between end-diastole (ED) and end-systole (ES), while the 2D technique yielded significantly larger values for the LV myocardial volume at ES than ED (mean difference=14.7%±16.8%, p±0.0001). (umn.edu)
  • Swingen, C, Wang, X & Jerosch-Herold, M 2004, ' Evaluation of myocardial volume heterogeneity during end-diastole and end-systole using cine MRI ', Journal of Cardiovascular Magnetic Resonance , vol. 6, no. 4, pp. 829-835. (umn.edu)
  • The terms diastole and systole refer to when the heart muscles relax and contract. (medicalnewstoday.com)
  • The terms diastole and systole apply to the relaxing and contraction of heart muscles. (nccmed.com)
  • and 0.5 sec in diastole (dilation), re-filling the four chambers of the heart, for a total of 0.8 sec to complete the cycle. (wikipedia.org)
  • The term diastole originates from the Greek word διαστολή ( diastolè ), meaning dilation. (orange.com)
  • The rhythmic contraction of the heart, especially of the ventricles, by which blood is driven through the aorta and pulmonary artery after each dilation or diastole. (gradydoctor.com)
  • Diastole is when the heart muscle relaxes and systole is when the heart muscle contracts. (medicalnewstoday.com)
  • Diastole (pronounced di-as´to-le, rhymes with "potentially") is the period of time when the heart relaxes after contraction. (bionity.com)
  • 4,5 Titin is a huge elastic protein that extends across each half-sarcomere and is stretched in diastole when the sarcomere relaxes. (ahajournals.org)
  • Diastole, pronounced (dy-AS-tuh-lee), is a medical term for the interim between heartbeats, when the heart muscle relaxes. (diastole.org)
  • It consists of two periods: one during which the heart muscle relaxes and refills with blood, called diastole , following a period of robust contraction and pumping of blood, dubbed systole . (wikipedia.org)
  • During early ventricular diastole, pressure in the two ventricles begins to drop from the peak reached during systole. (wikipedia.org)
  • Then, in late ventricular diastole, the two atrial chambers contract (atrial systole), causing blood pressure in both atria to increase and forcing additional blood flow into the ventricles. (wikipedia.org)
  • Ejection causes pressure within the ventricles to fall, and, simultaneously, the atria begin to refill (atrial diastole). (wikipedia.org)
  • When, in late diastole, the ventricles become fully dilated (understood in imaging as LVEDV and RVEDV), the atria begin to contract, pumping blood to the ventricles. (wikipedia.org)
  • Ventricular diastole is the period during which the ventricles are relaxing, while atrial diastole is the period during which the atria are relaxing. (bionity.com)
  • During ventricular diastole, the pressure in the (left and right) ventricles drops from the peak that it reaches in systole . (bionity.com)
  • Later in diastole, the sinoatrial (SA) node fires causing both atria to contract and expel the little bit of blood remaining in them into the ventricles before the atrioventricular valves close. (picmonic.com)
  • Atrial systole occurs toward the end of ventricular diastole, completing the filling of the ventricles. (britannica.com)
  • [3] During ventricular systole the ventricles are contracting and vigorously pulsing (or ejecting) two separated blood supplies from the heart-one to the lungs and one to all other body organs and systems-while the two atria are relaxed ( atrial diastole ). (wikipedia.org)
  • The lower diastolic augmentation of the LAA outflow velocity at the ventricular diastolic phase might result from interference with the suction effect of the left ventricular diastole by the stenotic mitral valve. (ncku.edu.tw)
  • The ventricular systole is followed by a resting or filling phase that is called diastole . (kdnuggets.com)
  • ventricular diastole followed by ventricular systole , etc.-while coordinating with atrial systole followed by atrial diastole , etc. (wikipedia.org)
  • 9) In M-mode echocardiography, ventricular septal and posterior wall thicknesses were measured at end diastole through a parasternal long-axis view. (freethesaurus.com)
  • With respect to recent guidelines and recommendations, this review summarizes the physiology and pathophysiology of diastole, current echocardiographic methods and calculated echocardiographic parameters for the assessment of left ventricular diastolic function and dysfunction. (minervamedica.it)
  • Judd, RM, Redberg, DA & Mates, RE 1991, ' Diastolic coronary resistance and capacitance are independent of the duration of diastole ', American Journal of Physiology - Heart and Circulatory Physiology , vol. 260, no. 3 29-3, pp. (elsevier.com)
  • Note that at this time-indeed, throughout all of diastole-the aortic valve is closed because the aortic pressure is higher than the ventricular pressure. (78stepshealth.us)
  • This contraction phase is known as the systole, and the relaxation phase is called the diastole . (medicalterms.info)
  • The cycle involves systole (the contraction phase) and diastole (the relaxation phase). (encyclopedia.com)
  • The balance between diastole and systole determines a person's blood pressure. (medicalnewstoday.com)
  • A person's blood pressure is determined by the difference between diastole and systèmeole. (nccmed.com)
  • Impairment of relaxation, the early phase of ventricular diastole is the first stage of heart diastolic dysfunction. (clinicaltrials.gov)
  • What are diastole and systole in blood pressure? (medicalnewstoday.com)
  • In this article, we will explain how diastole and systole relate to blood pressure . (medicalnewstoday.com)
  • When a person receives their blood pressure results, they will see two numbers that represent the diastole and systole measurements. (medicalnewstoday.com)
  • The individual muscle-fibres contract and expand more perfectly, and thus the diastole and systole of the heart are rendered more complete, the pulse is slowed, and the blood-pressure is raised. (yourdictionary.com)
  • In the resting period between two systoles (diastole), the heart is filled by the blood from the venous return. (rupress.org)
  • In this article we'll clarify how blood pressure is linked to diastole and systole. (nccmed.com)
  • Once a person receives the results of his blood pressure they can see two numbers reflecting the measures of the diastole and the systole. (nccmed.com)
  • When the heart is relaxed and filling with blood it is known as diastole. (abpischools.org.uk)
  • For the Greek punctuation mark sometimes known as the diastole, see Hypodiastole . (orange.com)
  • How would you define diastole? (yourdictionary.com)
  • How to Define End-Diastole and End-Systole? (onlinejacc.org)
  • Objectives This study aimed to investigate to what extent timing definitions influence strain measurements and which surrogates are reliable and feasible to define end-diastole (ED) and end-systole (ES) during speckle-tracking (STI) analysis. (onlinejacc.org)
  • With vasomotor tone intact, the parameters of a lumped model of the coronary circulation showed no variation from early to late diastole. (elsevier.com)
  • Dr. and Mrs. Dimond began building Diastole in 1976 and lived here until Mrs. Dimond's death in 1983. (diastole.org)
  • Some patients developed diastole impairment after a few months on the drugs, an early sign of congestive heart failure. (freethesaurus.com)
  • Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: time for a redefinition? (bmj.com)
  • Templeton, GH, Ecker, RR & Mitchell, JH 1972, ' Left ventricular stiffness during diastole and systole: The influence of changes in volume and inotropic state ', Cardiovascular Research , vol. 6, no. 1, pp. 95-100. (elsevier.com)
  • atrial diastole is the period during which the two atria likewise are relaxing under suction, dilating, and filling. (wikipedia.org)
  • Early diastole is a suction mechanism between the atrial and ventricular chambers. (wikipedia.org)
  • Ja a diastole (PAD), ocorre no momento em que o ventriculo esquerdo volta a encher-se para reiniciar todo o processo da circulacao. (freethesaurus.com)
  • El volumen diastólico finalo volumen de fin de diastole(VFD), es el volumen al momento de una presión de fin de sístole (PFS), y es función de la contractilidad ventricular. (comunidades.net)
  • Diastole concludes when the atrioventricular valves close. (picmonic.com)
  • The mitral and tricuspid valves, also known as the atrioventricular, or AV valves , open during ventricular diastole to permit filling. (wikipedia.org)
  • Although HRV affects pump function on a beat-to-beat basis, no systematic study addresses the relative contribution of systole (S) and diastole (D). Thus, we analyzed the duration (T) by determining TS and TD in 2 conscious dogs instrumented with aortic flow probe. (vumc.nl)
  • Duration of diastole and its phases as a function of heart rate during supine bicycle exercise. (semanticscholar.org)
  • During this cycle, the period of relaxation is called diastole and the period of contraction is called systole. (medicalnewstoday.com)
  • During this process the relaxation period is called diastole, and the contraction period is called systole. (nccmed.com)
  • This period, the heart at rest, is Diastole. (diastole.org)
  • This study is designed to assess whether the ratio of transmitral E-wave velocity (E) to early diastole mitral velocity (Ea) is associated with cardiovascular events and progression to dialysis in patients with CKD stages 3-5. (nih.gov)
  • A Green Business Network Member Spotlight We recently chatted with Diastole Scholars' Center's executive director, Nancy Hill, and events assistant, Jennifer StClair, about the unique event venue that joined the Green Business Network last year. (bridgingthegap.org)
  • Subepicardial strains achieved their ED values during early diastole, while mid wall and subendocardial straius reset during late diastole. (diva-portal.org)
  • Using this method, coronary dynamics were measured during early and late diastoles in the beating heart with tone intact as well as during adenosine-induced maximal vasodilation. (elsevier.com)
  • During maximal vasodilation, model parameters also showed no variation from early to late diastole. (elsevier.com)