Organic chemicals which have two amino groups in an aliphatic chain.
A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.
A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.
Polyamines are organic compounds with more than one amino group, involved in various biological processes such as cell growth, differentiation, and apoptosis, and found to be increased in certain diseases including cancer.
A foul-smelling diamine formed by bacterial decarboxylation of lysine.
A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
Ethylenediamines are organic compounds containing two amine groups linked by a two-carbon chain, widely used in the manufacture of industrial and pharmaceutical products, including chelating agents and polymerization catalysts, but not typically used as a medication on their own.
A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Phenylenediamines are chemical compounds that contain two amino groups (-NH2) linked to a phenyl ring, which have been used in certain pharmaceuticals and industrial applications, but can also pose health risks as potential allergens and carcinogens.
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase.
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Enzymes catalyzing the dehydrogenation of secondary amines, introducing a C=N double bond as the primary reaction. In some cases this is later hydrolyzed.
A transmembrane glycoprotein subunit that can dimerize with a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS). This protein subunit serves a diverse array of functions including amino acid transport and cell fusion. Its function is altered depending which of the light chain subunits it interacts with.
A family of alicyclic hydrocarbons containing an amine group with the general formula R-C6H10NH2.
An enzyme that catalyzes the decarboxylation of S-adenosyl-L-methionine to yield 5'-deoxy-(5'-),3-aminopropyl-(1), methylsulfonium salt. It is one of the enzymes responsible for the synthesis of spermidine from putrescine. EC 4.1.1.50.
An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to histamine, forming N-methylhistamine, the major metabolite of histamine in man. EC 2.1.1.8.
Compounds of silver and proteins used as topical anti-infective agents.
Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.
Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.
An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).
Organic salts of cyanic acid containing the -OCN radical.
An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.
A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES.
Compounds that bind to and reduce the biological availability of a chemical or pharmaceutical agent.
An enzyme that catalyzes the transfer of the propylamine moiety from 5'-deoxy-5'-S-(3-methylthiopropylamine)sulfonium adenosine to putrescine in the biosynthesis of spermidine. The enzyme has a molecular weight of approximately 73,000 kDa and is composed of two subunits of equal size.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
2,2-Dihydroxy-1H-indene-1,3-(2H)-dione. Reagent toxic to skin and mucus membranes. It is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.
Semicarbazides are organic compounds containing a functional group with the structure NH2-NH-CO-NH2, which are commonly used as reagents in chemical reactions to form semicarbazones, and can also be found in some pharmaceuticals and industrial chemicals.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Aromatic diamine used in the plastics industry as curing agent for epoxy resins and urethane rubbers. It causes bladder, liver, lung, and other neoplasms.
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
An effective trypanocidal agent.
A plant genus in the family FABACEAE known for LATHYRISM poisoning.

M2 receptors in genito-urinary smooth muscle pathology. (1/405)

In vitro bladder contractions in response to cumulative carbachol doses were measured in the presence of selective muscarinic antagonists from rats which had their major pelvic ganglion bilaterally removed (denervation, DEN) or from rats in which the spinal cord was injured (SCI) via compression. DEN induced both hypertrophy (505+/-51 mg bladder weight) and a supersensitivity of the bladders to carbachol (EC50=0.7+/-0.1 uM). Some of the SCI rats regained the ability to void spontaneously (SPV). The bladders of these animals weighed 184+/-17 mg, significantly less than the bladders of non voiding rats (NV, 644+/-92 mg). The potency of carbachol was greater in bladder strips from NV SCI animals (EC50=0.54+/-0.1 uM) than either bladder strips from SPV SCI (EC50=0.93+/-0.3 microM), DEN or control (EC50=1.2+/-0.1 microM) animals. Antagonist affinities in control bladders for antagonism of carbachol induced contractions were consistent with M3 mediated contractions. Antagonist affinities in DEN bladders for 4-diphenlacetoxy-N-methylpiperidine methiodide (4-DAMP, 8.5) and para fluoro hexahydrosilodifenidol (p-F-HHSiD, 6.6); were consistent with M2 mediated contractions, although the methoctramine affinity (6.5) was consistent with M3 mediated contractions. p-F-HHSiD inhibited carbachol induced contraction with an affinity consistent with M2 receptors in bladders from NV SCI (pKb=6.4) animals and M3 receptors in bladders from SPV SCI animals (pKb=7.9). Subtype selective immunoprecipitation of muscarinic receptors revealed an increase in total and an increase in M2 receptor density with no change in M3 receptor density in bladders from DEN and NV SCI animals compared to normal or sham operated controls. M3 receptor density was lower in bladders from SPV SCI animals while the M2 receptor density was not different from control. This increase in M2 receptor density is consistent with the change in affinity of the antagonists for inhibition of carbachol induced contractions and may indicate that M2 receptors or a combination of M2 and M3 receptors directly mediate smooth muscle contraction in bladders from DEN and NV SCI rats.  (+info)

Inducing effect of diamines on transcription of the cephamycin C genes from the lat and pcbAB promoters in Nocardia lactamdurans. (2/405)

The diamines putrescine, cadaverine, and diaminopropane stimulate cephamycin biosynthesis in Nocardia lactamdurans, in shake flasks and fermentors, without altering cell growth. Intracellular levels of the P7 protein (a component of the methoxylation system involved in cephamycin biosynthesis) were increased by diaminopropane, as shown by immunoblotting studies. Lysine-6-aminotransferase and piperideine-6-carboxylate dehydrogenase activities involved in biosynthesis of the alpha-aminoadipic acid precursor were also greatly stimulated. The diamine stimulatory effect is exerted at the transcriptional level, as shown by low-resolution S1 protection studies. The transcript corresponding to the pcbAB gene and to a lesser extent also the lat transcript were significantly increased in diaminopropane-supplemented cultures, whereas transcription from the cefD promoter was not affected. Coupling of the lat and pcbAB promoters to the reporter xylE gene showed that expression from the lat and pcbAB promoters was increased by addition of diaminopropane in Streptomyces lividans. Intracellular accumulation of diamines in Nocardia may be a signal to trigger antibiotic production.  (+info)

Subtypes of muscarinic receptors regulating gallbladder cholinergic contractions. (3/405)

The aim of this study was to determine the functional role of muscarinic receptor subtypes regulating gallbladder cholinergic contractions. Electrical field stimulation (EFS; 16 Hz) produced contractile responses of guinea pig gallbladder muscle strips in vitro that were inhibited by 1 microM tetrodotoxin (2 +/- 2% of control) and 1 microM atropine (1 +/- 1% of control), indicating activation of intrinsic cholinergic nerves. Exogenous ACh (5 microM)-induced contractions were inhibited by atropine (1 +/- 1% of control) but not tetrodotoxin (102 +/- 1% of control), indicating a direct effect on smooth muscle. The M1 receptor antagonist pirenzepine (10 nM) had no effect on ACh-induced contractions but inhibited EFS-induced contractions by 11 +/- 3%. The M2 antagonist methoctramine (10 nM) had no effect on ACh-induced contractions but augmented EFS-induced contractions by 5 +/- 2%. The M3 antagonist 4-DAMP (10 nM) inhibited ACh-induced contractions by 14 +/- 4% and EFS-induced contractions by 22 +/- 5%. In conclusion, specific M1, M2, and M3 receptors modulate gallbladder muscle contractions by regulating ACh release from cholinergic nerves and mediating the contraction. Cholinergic contractions are mediated by M3 receptors directly on the smooth muscle. M2 receptors are on cholinergic nerves and function as prejunctional inhibitory autoreceptors. M1 receptors are on cholinergic nerves and function as prejunctional facilitatory autoreceptors.  (+info)

Antigen-induced hyperreactivity to histamine: role of the vagus nerves and eosinophils. (4/405)

M2 muscarinic receptors limit acetylcholine release from the pulmonary parasympathetic nerves. M2 receptors are dysfunctional in antigen-challenged guinea pigs, causing increased vagally mediated bronchoconstriction. Dysfunction of these M2 receptors is due to eosinophil major basic protein, which is an antagonist for M2 receptors. Histamine-induced bronchoconstriction is composed of a vagal reflex in addition to its direct effect on airway smooth muscle. Because hyperreactivity to histamine is seen in antigen-challenged animals, we hypothesized that hyperreactivity to histamine may be due to increased vagally mediated bronchoconstriction caused by dysfunction of M2 receptors. In anesthetized, antigen-challenged guinea pigs, histamine-induced bronchoconstriction was greater than that in control guinea pigs. After vagotomy or atropine treatment, the response to histamine in antigen-challenged animals was the same as that in control animals. In antigen-challenged animals, blockade of eosinophil influx into the airways or neutralization of eosinophil major basic protein prevented the development of hyperreactivity to histamine. Thus hyperreactivity to histamine in antigen-challenged guinea pigs is vagally mediated and dependent on eosinophil major basic protein.  (+info)

Characterization of a novel spermidine/spermine acetyltransferase, BltD, from Bacillus subtilis. (5/405)

Overexpression of the BltD gene in Bacillus subtilis causes acetylation of the polyamines spermidine and spermine. BltD is co-regulated with another gene, Blt, which encodes a multidrug export protein whose overexpression facilitates spermidine export [Woolridge, Vazquez-Laslop, Markham, Chevalier, Gerner and Neyfakh (1997) J. Biol. Chem. 272, 8864-8866]. Here we show that BltD acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. In the presence of saturating concentrations of acetyl CoA, BltD rapidly acetylates spermine at both the N1 and N12 positions. The Km (app) values for spermine, spermidine and N1-acetylspermine are +info)

Inhibition of GTPase activity of Gi proteins and decreased agonist affinity at M2 muscarinic acetylcholine receptors by spermine and methoctramine. (6/405)

1. The effects of spermine and methoctramine, a selective M2 muscarinic receptor antagonist, were studied on the high-affinity GTPase activity of G proteins, and on ligand binding to M2 muscarinic receptors in pig heart sarcolemma. 2. The spontaneous GTP hydrolysis by pig heart sarcolemma and its stimulation by mastoparan or carbachol were prevented by pertussis toxin and inhibited by methoctramine (IC50s: 21, 13 and 0.005 microM, respectively), and spermine (IC50s: 967, 278 and 11 microM). Spermine and methoctramine also inhibited spontaneous GTP hydrolysis by rat peritoneal mast cell membranes which do not respond to carbachol. 3. The neutral muscarinic antagonists, AF-DX 116 and atropine, did not modify the inhibitory effect of high concentrations of methoctramine, indicating that this effect was not related to the antagonist binding site of muscarinic receptors. We suggest that methoctramine behaves as a receptor antagonist at nanomolar concentrations and interacts with G proteins at micromolar concentrations. 4. Spermine did not modify the binding of the tritiated muscarinic antagonist [3H]-NMS, but decreased the binding of the agonist [3H]-Oxo-M. Spermine elicited a rightward shift of the carbachol/[3H]-NMS binding isotherm with a decrease in the proportion of sites with high-affinity for carbachol, suggesting that polyamines uncouple Gi proteins from receptors. 5. The inhibition of GTPase activity by polyamines, preventing the re-association of alpha and betagamma subunits of Gi proteins, might sustain the regulatory effect of Gi subunits on downstream effectors. The level of intracellular polyamines might be important for the control of the transduction of extracellular signals through Gi protein-coupled receptors.  (+info)

Inhibitory effects of 1,3-diaminopropane, an ornithine decarboxylase inhibitor, on rat two-stage urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. (7/405)

Overexpression of ornithine decarboxylase (ODC) has been shown to be characteristic of tumor development and progression in humans and experimental animals. Therefore, we have examined the effects of 1, 3-diaminopropane dihydrochloride (DAP), a potent inhibitor of ODC, on rat two-stage urinary bladder carcinogenesis initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). In experiment 1 (36 weeks), 6-week-old F344 male rats were administered 0.05% BBN in drinking water for 4 weeks and then divided into four groups. Animals of groups 1 and 2 received basal diet and drinking water supplemented with or without DAP (2 g/l). Groups 3 and 4 were given diet containing 5% sodium L-ascorbate (NaAsA), a typical urinary bladder tumor promoter, and drinking water with or without DAP. Administration of DAP to group 1 significantly reduced tumor size, multiplicity and incidence, particularly of papillomas, when compared with group 2 values. DAP together with NaAsA (group 3) also decreased tumor size relative to the group 4 case. To determine the effects of DAP on the early stages of bladder carcinogenesis and its mechanisms, a similar protocol was conducted (experiment 2) with death after 20 weeks. DAP treatment caused complete inhibition (0% incidence) of papillary and/or nodular hyperplasia in group 1 but was without influence in group 3, as compared with the respective controls. Moreover, the ODC activity, bromodeoxyuridine labeling indices and mRNA expression levels of cyclin D1 in the urinary bladder mucosa, determined by northern blotting, were markedly lower in group 1 than in group 2, but values were comparable for both groups administered NaAsA. Assessment of mRNA expression levels of the angiogenic vascular endothelial growth factor suggested no involvement in the inhibitory effects of DAP on urinary bladder carcinogenesis. The results indicate that inhibition of ODC could reduce urinary bladder carcinogenesis in rats, particularly in the early stages, through antiproliferative mechanisms.  (+info)

Molecular mode of interaction of plant amine oxidase with the mechanism-based inhibitor 2-butyne-1,4-diamine. (8/405)

2-Butyne-1,4-diamine (DABI) is a mechanism-based inhibitor of copper-containing plant amine oxidases; the number of turnovers that leads to enzyme inactivation is approximately 20. The product of DABI oxidation is a very reactive aminoallene that reacts with an essential nucleophilic group at the enzyme active site, forming a covalently bound pyrrole and producing an inactive enzyme. The inactivated enzyme shows a new absorption maximum at 295 nm and gives coloured derivatives with p-dimethylaminobenzaldehyde and p-dimethylaminocinnamaldehyde that are spectrally similar to the products of pyrrole treated with the above reagents. Resonance Raman spectra of the p-dimethylaminobenzaldehyde adduct of pyrrole and the inactivated enzyme show very high degree of similarity, supporting the idea that the product of inactivation is indeed a bound pyrrole. The bound pyrrole is formed already in the anaerobic step of the reaction, while the topa semiquinone radical is not affected, as shown by the EPR and stopped-flow absorption measurements. Peptides containing the DABI binding site were obtained by proteolysis of inactivated enzyme, isolated by HPLC and analysed by amino acid sequencing and MS. The crystal structure of the amine oxidase from pea has been determined; inhibition is caused mainly by the highly reactive DABI product, 4-amino-2-butynal, binding to a nucleophilic residue at the entrance to the substrate channel. As other DABI labelled peptides were also found and no free DABI product was detected by MS after complete inhibition of the enzyme, it is likely that the DABI product binds also to other solvent exposed nucleophilic residues on the enzyme surface.  (+info)

'Diamines' are organic compounds containing two amino groups (-NH2) in their molecular structure. The term 'diamine' itself does not have a specific medical definition, but it is used in the context of chemistry and biochemistry.

Diamines can be classified based on the number of carbon atoms between the two amino groups. For example, ethylenediamine and propylenediamine are diamines with one and two methylene (-CH2-) groups, respectively.

In medicine, certain diamines may have biological significance. For instance, putrescine and cadaverine are polyamines that are produced during the decomposition of animal tissues and can be found in necrotic or infected tissues. These compounds have been implicated in various pathological processes, including inflammation, oxidative stress, and cancer progression.

It is important to note that while some diamines may have medical relevance, the term 'diamines' itself does not have a specific medical definition.

Putrescine is an organic compound with the chemical formula NH2(CH2)4NH2. It is a colorless, viscous liquid that is produced by the breakdown of amino acids in living organisms and is often associated with putrefaction, hence its name. Putrescine is a type of polyamine, which is a class of organic compounds that contain multiple amino groups.

Putrescine is produced in the body through the decarboxylation of the amino acid ornithine by the enzyme ornithine decarboxylase. It is involved in various cellular processes, including the regulation of gene expression and cell growth. However, at high concentrations, putrescine can be toxic to cells and has been implicated in the development of certain diseases, such as cancer.

Putrescine is also found in various foods, including meats, fish, and some fruits and vegetables. It contributes to the unpleasant odor that develops during spoilage, which is why putrescine is often used as an indicator of food quality and safety.

Polyamines are organic compounds with more than one amino group (-NH2) and at least one carbon atom bonded to two or more amino groups. They are found in various tissues and fluids of living organisms and play important roles in many biological processes, such as cell growth, differentiation, and apoptosis (programmed cell death). Polyamines are also involved in the regulation of ion channels and transporters, DNA replication and gene expression. The most common polyamines found in mammalian cells are putrescine, spermidine, and spermine. They are derived from the decarboxylation of amino acids such as ornithine and methionine. Abnormal levels of polyamines have been associated with various pathological conditions, including cancer and neurodegenerative diseases.

Cadaverine is a foul-smelling organic compound that is produced by the breakdown of certain amino acids in dead bodies. It is formed through the decarboxylation of lysine, an essential amino acid, and is characterized by its strong, unpleasant odor. Cadaverine is often used as a forensic indicator of decomposition and is also being studied for its potential role in various physiological processes, such as inflammation and cancer.

Spermidine is a polycationic polyamine that is found in various tissues and fluids, including semen, from which it derives its name. It is synthesized in the body from putrescine, another polyamine, through the action of the enzyme spermidine synthase.

In addition to its role as a metabolic intermediate, spermidine has been shown to have various cellular functions, including regulation of gene expression, DNA packaging and protection, and modulation of enzymatic activities. It also plays a role in the process of cell division and differentiation.

Spermidine has been studied for its potential anti-aging effects, as it has been shown to extend the lifespan of various organisms, including yeast, flies, and worms, by activating autophagy, a process by which cells break down and recycle their own damaged or unnecessary components. However, more research is needed to determine whether spermidine has similar effects in humans.

Ethylenediamines are organic compounds that contain two amine groups (-NH2) separated by two methylene bridges (-CH2-). The general formula for ethylenediamines is C2H8N2. They can act as a chelating agent, forming stable complexes with many metal ions. Ethylenediamines are used in various industrial and pharmaceutical applications, including the manufacture of resins, textile dyes, and as a solvent for cellulose acetate. In medicine, they can be used as a vasodilator and in the treatment of urinary tract infections.

Spermine is a polyamine compound that is involved in various biological processes, including cell growth and differentiation, DNA packaging, and gene expression. It is synthesized from the amino acid ornithine through a series of enzymatic reactions and is found in high concentrations in tissues such as the prostate gland, liver, and brain. Spermine has been shown to have antioxidant properties and may play a role in protecting cells against oxidative stress. In addition, spermine has been implicated in the regulation of ion channels and receptors, and may be involved in the modulation of neuronal excitability.

Amines are organic compounds that contain a basic nitrogen atom with a lone pair of electrons. They are derived from ammonia (NH3) by replacing one or more hydrogen atoms with alkyl or aryl groups. The nomenclature of amines follows the substitutive type, where the parent compound is named as an aliphatic or aromatic hydrocarbon, and the functional group "amine" is designated as a suffix or prefix.

Amines are classified into three types based on the number of carbon atoms attached to the nitrogen atom:

1. Primary (1°) amines: One alkyl or aryl group is attached to the nitrogen atom.
2. Secondary (2°) amines: Two alkyl or aryl groups are attached to the nitrogen atom.
3. Tertiary (3°) amines: Three alkyl or aryl groups are attached to the nitrogen atom.

Quaternary ammonium salts have four organic groups attached to the nitrogen atom and a positive charge, with anions balancing the charge.

Amines have a wide range of applications in the chemical industry, including pharmaceuticals, dyes, polymers, and solvents. They also play a significant role in biological systems as neurotransmitters, hormones, and cell membrane components.

Phenylenediamines are a class of organic compounds that contain a phenylene diamine group, which consists of two amino groups (-NH2) attached to a benzene ring. They are used in various applications, including as intermediates in the synthesis of dyes and pigments, pharmaceuticals, and agrochemicals. Some phenylenediamines also have potential use as antioxidants and reducing agents.

In a medical context, some phenylenediamines are used in the manufacture of certain drugs, such as certain types of local anesthetics and vasodilators. However, it's important to note that not all phenylenediamines have medical applications, and some may even be harmful or toxic in certain contexts.

Exposure to phenylenediamines can occur through various routes, including skin contact, inhalation, or ingestion. Some people may experience allergic reactions or irritation after exposure to certain phenylenediamines, particularly those used in hair dyes and cosmetics. It's important to follow proper safety precautions when handling these compounds, including wearing protective clothing and using appropriate ventilation.

Ornithine decarboxylase (ODC) is a medical/biochemical term that refers to an enzyme (EC 4.1.1.17) involved in the metabolism of amino acids, particularly ornithine. This enzyme catalyzes the decarboxylation of ornithine to form putrescine, which is a precursor for the synthesis of polyamines, such as spermidine and spermine. Polyamines play crucial roles in various cellular processes, including cell growth, differentiation, and gene expression.

Ornithine decarboxylase is a rate-limiting enzyme in polyamine biosynthesis, meaning that its activity regulates the overall production of these molecules. The regulation of ODC activity is tightly controlled at multiple levels, including transcription, translation, and post-translational modifications. Dysregulation of ODC activity has been implicated in several pathological conditions, such as cancer, neurodegenerative disorders, and inflammatory diseases.

Inhibitors of ornithine decarboxylase have been explored as potential therapeutic agents for various diseases, including cancer, due to their ability to suppress polyamine synthesis and cell proliferation. However, the use of ODC inhibitors in clinical settings has faced challenges related to toxicity and limited efficacy.

Mitoguazone is not typically referred to as a medical "definition" but rather it is a chemical compound that has been investigated for its potential therapeutic benefits. It's also known as NSC 3852 and is an antineoplastic agent, which means it is used to treat cancer.

Mitoguazone works by inhibiting the synthesis of DNA, RNA, and proteins in cancer cells, which can ultimately lead to cell death. It has been studied in clinical trials for the treatment of various types of cancer, including brain tumors and leukemia. However, its development as a therapeutic agent was discontinued due to its toxicity and lack of efficacy in later-stage clinical trials.

Therefore, while mitoguazone is not a medical definition per se, it is a chemical compound with known pharmacological properties and a history of investigation for cancer therapy.

Alkynes are a type of hydrocarbons that contain at least one carbon-carbon triple bond in their molecular structure. The general chemical formula for alkynes is CnH2n-2, where n represents the number of carbon atoms in the molecule.

The simplest and shortest alkyne is ethyne, also known as acetylene, which has two carbon atoms and four hydrogen atoms (C2H2). Ethyne is a gas at room temperature and pressure, and it is commonly used as a fuel in welding torches.

Alkynes are unsaturated hydrocarbons, meaning that they have the potential to undergo chemical reactions that add atoms or groups of atoms to the molecule. In particular, alkynes can be converted into alkenes (hydrocarbons with a carbon-carbon double bond) through a process called partial reduction, or they can be fully reduced to alkanes (hydrocarbons with only single bonds between carbon atoms) through a process called complete reduction.

Alkynes are important intermediates in the chemical industry and are used to produce a wide range of products, including plastics, resins, fibers, and pharmaceuticals. They can be synthesized from other hydrocarbons through various chemical reactions, such as dehydrogenation, oxidative coupling, or metathesis.

Ornithine is not a medical condition but a naturally occurring alpha-amino acid, which is involved in the urea cycle, a process that eliminates ammonia from the body. Here's a brief medical/biochemical definition of Ornithine:

Ornithine (NH₂-CH₂-CH₂-CH(NH₃)-COOH) is an α-amino acid without a carbon atom attached to the amino group, classified as a non-proteinogenic amino acid because it is not encoded by the standard genetic code and not commonly found in proteins. It plays a crucial role in the urea cycle, where it helps convert harmful ammonia into urea, which can then be excreted by the body through urine. Ornithine is produced from the breakdown of arginine, another amino acid, via the enzyme arginase. In some medical and nutritional contexts, ornithine supplementation may be recommended to support liver function, wound healing, or muscle growth, but its effectiveness for these uses remains a subject of ongoing research and debate.

Guanidines are organic compounds that contain a guanidino group, which is a functional group with the formula -NH-C(=NH)-NH2. Guanidines can be found in various natural sources, including some animals, plants, and microorganisms. They also occur as byproducts of certain metabolic processes in the body.

In a medical context, guanidines are most commonly associated with the treatment of muscle weakness and neuromuscular disorders. The most well-known guanidine compound is probably guanidine hydrochloride, which has been used as a medication to treat conditions such as myasthenia gravis and Eaton-Lambert syndrome.

However, the use of guanidines as medications has declined in recent years due to their potential for toxicity and the development of safer and more effective treatments. Today, guanidines are mainly used in research settings to study various biological processes, including protein folding and aggregation, enzyme inhibition, and cell signaling.

Histamine is defined as a biogenic amine that is widely distributed throughout the body and is involved in various physiological functions. It is derived primarily from the amino acid histidine by the action of histidine decarboxylase. Histamine is stored in granules (along with heparin and proteases) within mast cells and basophils, and is released upon stimulation or degranulation of these cells.

Once released into the tissues and circulation, histamine exerts a wide range of pharmacological actions through its interaction with four types of G protein-coupled receptors (H1, H2, H3, and H4 receptors). Histamine's effects are diverse and include modulation of immune responses, contraction and relaxation of smooth muscle, increased vascular permeability, stimulation of gastric acid secretion, and regulation of neurotransmission.

Histamine is also a potent mediator of allergic reactions and inflammation, causing symptoms such as itching, sneezing, runny nose, and wheezing. Antihistamines are commonly used to block the actions of histamine at H1 receptors, providing relief from these symptoms.

Oxidoreductases acting on CH-NH group donors are a class of enzymes within the larger group of oxidoreductases, which are responsible for catalyzing oxidation-reduction reactions. Specifically, this subclass of enzymes acts on CH-NH group donors, where the CH-NH group is a chemical functional group consisting of a carbon atom (C) bonded to a nitrogen atom (N) via a single covalent bond.

These enzymes play a crucial role in various biological processes by transferring electrons from the CH-NH group donor to an acceptor molecule, which results in the oxidation of the donor and reduction of the acceptor. This process can lead to the formation or breakdown of chemical bonds, and plays a key role in metabolic pathways such as amino acid degradation and nitrogen fixation.

Examples of enzymes that fall within this class include:

* Amino oxidases, which catalyze the oxidative deamination of amino acids to produce alpha-keto acids, ammonia, and hydrogen peroxide.
* Transaminases, which transfer an amino group from one molecule to another, often in the process of amino acid biosynthesis or degradation.
* Amine oxidoreductases, which catalyze the oxidation of primary amines to aldehydes and secondary amines to ketones, with the concomitant reduction of molecular oxygen to hydrogen peroxide.

CD98 heavy chain is a type of protein found on the surface of many different types of cells in the human body. It is also known as SLCA1 or 4F2hc. The CD98 heavy chain combines with various other proteins to form transporter proteins, which are involved in the transport of various molecules across the cell membrane.

In the context of immunology and medical terminology, antigens are substances (usually proteins) on the surface of cells, viruses, fungi, or bacteria that can be recognized by the immune system and stimulate an immune response. The CD98 heavy chain is not typically referred to as an antigen itself, but it may contribute to the overall antigenic properties of the cell expressing it.

However, it's important to note that the term "CD98 Heavy Chain" refers to a specific protein and not a medical condition or disease. If you have any specific concerns about this protein or its role in health and disease, I would recommend consulting with a healthcare professional or a researcher in the field of immunology.

Cyclohexylamines are a class of organic compounds that consist of a cyclohexane ring (a six-carbon saturated ring) with an amine group (-NH2, -NHR, or -NR2) attached to it. The amine group can be primary (one alkyl group attached to the nitrogen atom), secondary (two alkyl groups attached to the nitrogen atom), or tertiary (three alkyl groups attached to the nitrogen atom).

Cyclohexylamines have a wide range of applications in the chemical industry, including as intermediates in the synthesis of pharmaceuticals, agrochemicals, and dyes. Some cyclohexylamines are also used as solvents or extractants. However, some cyclohexylamines can be toxic or have harmful effects on human health, so they must be handled with care.

Adenosylmethionine decarboxylase (AdoMetDC) is an enzyme that plays a crucial role in the biosynthesis of polyamines, which are essential molecules for cell growth and differentiation. The enzyme catalyzes the decarboxylation of S-adenosylmethionine (SAM) to produce decarboxylated SAM, also known as deoxyadenosylcobalamin or coenzyme M.

Decarboxylated SAM serves as an aminopropyl group donor in the biosynthesis of polyamines such as spermidine and spermine. These polyamines are involved in various cellular processes, including DNA replication, transcription, translation, protein synthesis, and cell signaling.

AdoMetDC is a pyridoxal-5'-phosphate (PLP)-dependent enzyme that requires the cofactor vitamin B12 for its activity. It is found in various organisms, including bacteria, yeast, plants, and animals. In humans, AdoMetDC is encoded by the AMD1 gene and is localized mainly in the cytosol of cells.

Dysregulation of AdoMetDC activity has been implicated in several diseases, such as cancer, neurodegenerative disorders, and cardiovascular diseases. Therefore, targeting AdoMetDC with inhibitors or activators has emerged as a potential therapeutic strategy for treating these conditions.

Histamine N-methyltransferase (HNMT) is an enzyme that plays a role in the metabolism and degradation of histamine, which is a biogenic amine involved in various physiological and pathophysiological processes. Histamine is released by mast cells and basophils during allergic reactions and inflammation, and it can cause symptoms such as itching, sneezing, runny nose, and wheezing.

HNMT is responsible for methylating the primary amino group of histamine, forming N-methylhistamine, which is then further metabolized by other enzymes. HNMT is primarily found in tissues such as the liver, kidney, and intestine, but it is also present in the brain and other organs.

Inhibition of HNMT has been suggested to be a potential therapeutic strategy for treating histamine-mediated disorders, such as allergies, asthma, and inflammatory bowel disease. However, more research is needed to fully understand the role of HNMT in these conditions and to develop effective treatments that target this enzyme.

Silver proteins are a type of compound that consists of silver ions (Ag+) bonded to protein molecules. These compounds are often used in medical applications, including topical creams and ointments, for their antimicrobial properties. The silver ions in the compound can help to kill or inhibit the growth of a wide range of microorganisms, including bacteria, fungi, and viruses.

The protein component of silver proteins helps to stabilize the silver ions and control their release, which can improve the efficacy and safety of the product. The protein may also help to enhance the penetration of the silver ions into the skin or other tissues, allowing for more effective killing of microorganisms.

Silver proteins are used in a variety of medical products, including wound dressings, creams and gels for the treatment of burns and other types of wounds, and as a coating on medical devices to prevent infection. They have been shown to be effective against a wide range of microorganisms, including antibiotic-resistant strains, making them a valuable tool in the fight against infectious diseases.

Agmatine is a natural decarboxylated derivative of the amino acid L-arginine. It is formed in the body through the enzymatic degradation of arginine by the enzyme arginine decarboxylase. Agmatine is involved in various biological processes, including serving as a neurotransmitter and neuromodulator in the central nervous system. It has been shown to play roles in regulating pain perception, insulin secretion, cardiovascular function, and cell growth. Agmatine can also interact with several receptors, such as imidazoline receptors, α2-adrenergic receptors, and NMDA receptors, which contributes to its diverse physiological effects.

Carboxy-lyases are a class of enzymes that catalyze the removal of a carboxyl group from a substrate, often releasing carbon dioxide in the process. These enzymes play important roles in various metabolic pathways, such as the biosynthesis and degradation of amino acids, sugars, and other organic compounds.

Carboxy-lyases are classified under EC number 4.2 in the Enzyme Commission (EC) system. They can be further divided into several subclasses based on their specific mechanisms and substrates. For example, some carboxy-lyases require a cofactor such as biotin or thiamine pyrophosphate to facilitate the decarboxylation reaction, while others do not.

Examples of carboxy-lyases include:

1. Pyruvate decarboxylase: This enzyme catalyzes the conversion of pyruvate to acetaldehyde and carbon dioxide during fermentation in yeast and other organisms.
2. Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO): This enzyme is essential for photosynthesis in plants and some bacteria, as it catalyzes the fixation of carbon dioxide into an organic molecule during the Calvin cycle.
3. Phosphoenolpyruvate carboxylase: Found in plants, algae, and some bacteria, this enzyme plays a role in anaplerotic reactions that replenish intermediates in the citric acid cycle. It catalyzes the conversion of phosphoenolpyruvate to oxaloacetate and inorganic phosphate.
4. Aspartate transcarbamylase: This enzyme is involved in the biosynthesis of pyrimidines, a class of nucleotides. It catalyzes the transfer of a carboxyl group from carbamoyl aspartate to carbamoyl phosphate, forming cytidine triphosphate (CTP) and fumarate.
5. Urocanase: Found in animals, this enzyme is involved in histidine catabolism. It catalyzes the conversion of urocanate to formiminoglutamate and ammonia.

Eflornithine is a antiprotozoal medication, which is used to treat sleeping sickness (human African trypanosomiasis) caused by Trypanosoma brucei gambiense in adults and children. It works by inhibiting the enzyme ornithine decarboxylase, which is needed for the growth of the parasite. By doing so, it helps to control the infection and prevent further complications.

Eflornithine is also used as a topical cream to slow down excessive hair growth in women due to a condition called hirsutism. It works by interfering with the growth of hair follicles.

It's important to note that Eflornithine should be used under the supervision of a healthcare professional, and it may have side effects or interactions with other medications.

Amino alcohols are organic compounds containing both amine and hydroxyl (alcohol) functional groups. They have the general structure R-NH-OH, where R represents a carbon-containing group. Amino alcohols can be primary, secondary, or tertiary, depending on the number of alkyl or aryl groups attached to the nitrogen atom.

These compounds are important in many chemical and biological processes. For example, some amino alcohols serve as intermediates in the synthesis of pharmaceuticals, dyes, and polymers. In biochemistry, certain amino alcohols function as neurotransmitters or components of lipids.

Some common examples of amino alcohols include:

* Ethanolamine (monoethanolamine, MEA): a primary amino alcohol used in the production of detergents, emulsifiers, and pharmaceuticals
* Serinol: a primary amino alcohol that occurs naturally in some foods and is used as a flavoring agent
* Choline: a quaternary ammonium compound with a hydroxyl group, essential for human nutrition and found in various foods such as eggs, liver, and peanuts
* Trimethylamine (TMA): a tertiary amino alcohol that occurs naturally in some marine animals and is responsible for the "fishy" odor of their flesh.

Cyanates are a class of chemical compounds that contain the functional group -O-C≡N, which consists of a carbon atom triple-bonded to a nitrogen atom and double-bonded to an oxygen atom. In medical terms, cyanates are not commonly used, but potassium cyanate has been studied in the past as a possible treatment for certain conditions such as angina and cyanide poisoning. However, its use is limited due to potential side effects and the availability of safer and more effective treatments. It's important to note that cyanides are highly toxic substances, and exposure to them can be life-threatening.

Iproniazid is a monoamine oxidase inhibitor (MAOI) drug that was initially used as an antitubercular agent but later found to have antidepressant properties. It works by blocking the breakdown of certain neurotransmitters, such as serotonin and dopamine, in the brain which helps to elevate mood and improve symptoms of depression. However, its use is limited due to the risk of serious side effects, including hypertensive crisis and serotonin syndrome, when taken with certain foods or other medications.

PQQ, or pyrroloquinoline quinone, is a redox cofactor that plays a role in the electron transfer chain and is involved in various redox reactions in the body. It can be found in some bacteria and plants, and there is evidence to suggest that it may also be present in human tissues. However, the exact role of PQQ as a cofactor in humans is not well understood and more research is needed to fully understand its functions and potential health benefits.

A cofactor is a non-protein chemical compound that is required for an enzyme to function. Cofactors can be inorganic ions, such as iron or magnesium, or organic molecules, like PQQ. They play a crucial role in catalyzing biochemical reactions and maintaining the structural integrity of proteins.

In summary, PQQ is a redox cofactor that may have a role in various redox reactions in the body, but its exact functions and significance in human health are still being studied.

Sequestering agents, also known as chelating agents, are substances that bind to metal ions and form stable, soluble complexes with them. This process is called chelation. Sequestering agents are used in medicine to remove toxic heavy metals from the body, such as lead, mercury, or iron, in cases of poisoning. They can also be used to prevent the formation of harmful free radicals by binding to metal ions that may catalyze their production. Examples of sequestering agents include ethylenediaminetetraacetic acid (EDTA), dimercaprol, and penicillamine.

Spermidine synthase is an enzyme (EC 2.5.1.16) that catalyzes the synthesis of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). This reaction is a part of the polyamine biosynthetic pathway, which plays a crucial role in cell growth and differentiation.

The reaction catalyzed by spermidine synthase can be represented as follows:
putrescine + dcSAM → spermidine + S-adenosylhomocysteine

In humans, there are two isoforms of spermidine synthase, namely, SRM and SMS. These isoforms share a common catalytic mechanism but differ in their subcellular localization and regulation. Mutations in the genes encoding spermidine synthase have been associated with certain diseases, such as cancer and neurological disorders.

Stereoisomerism is a type of isomerism (structural arrangement of atoms) in which molecules have the same molecular formula and sequence of bonded atoms, but differ in the three-dimensional orientation of their atoms in space. This occurs when the molecule contains asymmetric carbon atoms or other rigid structures that prevent free rotation, leading to distinct spatial arrangements of groups of atoms around a central point. Stereoisomers can have different chemical and physical properties, such as optical activity, boiling points, and reactivities, due to differences in their shape and the way they interact with other molecules.

There are two main types of stereoisomerism: enantiomers (mirror-image isomers) and diastereomers (non-mirror-image isomers). Enantiomers are pairs of stereoisomers that are mirror images of each other, but cannot be superimposed on one another. Diastereomers, on the other hand, are non-mirror-image stereoisomers that have different physical and chemical properties.

Stereoisomerism is an important concept in chemistry and biology, as it can affect the biological activity of molecules, such as drugs and natural products. For example, some enantiomers of a drug may be active, while others are inactive or even toxic. Therefore, understanding stereoisomerism is crucial for designing and synthesizing effective and safe drugs.

Edetic acid, also known as ethylenediaminetetraacetic acid (EDTA), is not a medical term per se, but a chemical compound with various applications in medicine. EDTA is a synthetic amino acid that acts as a chelating agent, which means it can bind to metallic ions and form stable complexes.

In medicine, EDTA is primarily used in the treatment of heavy metal poisoning, such as lead or mercury toxicity. It works by binding to the toxic metal ions in the body, forming a stable compound that can be excreted through urine. This helps reduce the levels of harmful metals in the body and alleviate their toxic effects.

EDTA is also used in some diagnostic tests, such as the determination of calcium levels in blood. Additionally, it has been explored as a potential therapy for conditions like atherosclerosis and Alzheimer's disease, although its efficacy in these areas remains controversial and unproven.

It is important to note that EDTA should only be administered under medical supervision due to its potential side effects and the need for careful monitoring of its use.

Ninhydrin, also known as reagent Triketohydrindene hydrate or by its chemical name 2,2-Dihydroxyindane-1,3-dione, is not a medical term itself but a reagent used in various scientific fields including forensic science and biochemistry. In the medical field, it is primarily used as a colorimetric reagent to detect and quantify amino acids and other related compounds.

When ninhydrin comes into contact with certain amino acids or their derivatives, such as primary amines, it forms a purple-colored complex called a Ruhemann's purple. This reaction is specific to certain functional groups (α-amino acids) and can be used for the detection and quantification of these compounds in various samples, including biological fluids like urine or blood.

In summary, Ninhydrin is not a medical term itself but a reagent that has applications in detecting and quantifying specific compounds within the medical field.

Semicarbazides are organic compounds that contain the functional group -NH-CO-NH-NH2. They are derivatives of hydrazine and carbamic acid, with the general structure (CH3)NHCSNH2. Semicarbazides are widely used in the synthesis of various chemical compounds, including heterocyclic compounds, pharmaceuticals, and agrochemicals.

In a medical context, semicarbazides themselves do not have any therapeutic use. However, they can be used in the preparation of certain drugs or drug intermediates. For example, semicarbazones, which are derivatives of semicarbazides, can be used to synthesize some antituberculosis drugs.

It is worth noting that semicarbazides and their derivatives have been found to have mutagenic and carcinogenic properties in some studies. Therefore, they should be handled with care in laboratory settings, and exposure should be minimized to reduce potential health risks.

Molecular structure, in the context of biochemistry and molecular biology, refers to the arrangement and organization of atoms and chemical bonds within a molecule. It describes the three-dimensional layout of the constituent elements, including their spatial relationships, bond lengths, and angles. Understanding molecular structure is crucial for elucidating the functions and reactivities of biological macromolecules such as proteins, nucleic acids, lipids, and carbohydrates. Various experimental techniques, like X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy (cryo-EM), are employed to determine molecular structures at atomic resolution, providing valuable insights into their biological roles and potential therapeutic targets.

I'm sorry for the confusion, but "Palladium" is not a medical term. It is a chemical element with symbol Pd and atomic number 46. It is a rare and lustrous silvery-white metal discovered in 1803 by William Hyde Wollaston. It's used in various applications, including jewelry, dental work, electronics, and chemical reactions. If you have any medical terms you would like me to define, please let me know!

Diminazene is an antiparasitic drug, primarily used in veterinary medicine to treat and prevent infections caused by trypanosomes, which are protozoan parasites that can affect both animals and humans. The drug works by inhibiting the protein synthesis of the parasite, leading to its death.

In human medicine, diminazene is used as an alternative treatment for acute African trypanosomiasis (sleeping sickness) caused by Trypanosoma brucei gambiense in areas where other treatments are not available or have failed. It is usually given by intramuscular injection and is often used in combination with suramin.

It's important to note that the use of diminazene in human medicine is limited due to its potential toxicity, and it should only be administered under the supervision of a healthcare professional.

"Lathyrus" is a genus of plants, also known as "peavines" or "sweet peas." While not a medical term itself, certain species of Lathyrus contain a toxin called beta-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP) that can cause a neurological disorder known as lathyrism if consumed in large quantities. This condition is characterized by the degeneration of nerve cells and can lead to muscle spasticity and paralysis. However, it's important to note that this is not a common occurrence and typically only happens under conditions of severe malnutrition or famine when these plants are used as a primary food source.

4-diamine) 5 carbons: cadaverine (pentane-1,5-diamine) Cadaverine 6 carbons: hexamethylenediamine (hexane-1,6-diamine), ... A diamine is an amine with exactly two amino groups. Diamines are used as monomers to prepare polyamides, polyimides, and ... The term diamine refers mostly to primary diamines, as those are the most reactive. In terms of quantities produced, 1,6- ... Vicinal diamines (1,2-diamines) are a structural motif in many biological compounds and are used as ligands in coordination ...
... (usually shortened to IPDA) is a chemical compound and specifically a diamine with the formula (CH3)3C6H7( ... Like other diamines or amines in general, it is a curing agent for epoxy resins. When used in coatings applications the higher ... "Direct Air Capture of CO 2 Using a Liquid Amine-Solid Carbamic Acid Phase-Separation System Using Diamines Bearing an ...
In case of a shortage or low enzymatic activity of diamine oxidase in the human body, it may appear as an allergy or histamine ... Lowered diamine oxidase values in maternal blood in early pregnancy might be an indication for trophoblast-related pregnancy ... Diamine oxidase (DAO), also known "amine oxidase, copper-containing, 1" (AOC1), formerly called histaminase, is an enzyme (EC ... 2012). "The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs". PLOS ...
In enzymology, a diamine transaminase (EC 2.6.1.29) is an enzyme that catalyzes the chemical reaction: an alpha,omega-diamine ... Other names in common use include amine transaminase, amine-ketoacid transaminase, diamine aminotransferase, and diamine- ... Kim K (1964). "Purification and properties of a diamine alpha-ketoglutarate transaminase from Escherichia coli". J. Biol. Chem ... The systematic name of this enzyme class is diamine:2-oxoglutarate aminotransferase. ...
It is a diamine and thus in polymer science terms is a Chain extender rather than a chain terminator. Chain extenders (f = 2) ... Diethyl toluene diamine (DETDA) is a liquid aromatic organic molecule with formula C11H18N2. It is chemically an aromatic ... diamine and has the CAS Registry number of 68479-98-1. It has more than one isomer and the mixture of the two main isomers is ...
... (HMTD) is a high explosive organic compound. HMTD is an organic peroxide, a heterocyclic ... Schaefer, William P.; Fourkas, John T.; Tiemann, Bruce G. (April 1985). "Structure of hexamethylene triperoxide diamine". ...
In enzymology, a diamine N-acetyltransferase (EC 2.3.1.57) is an enzyme that catalyzes the chemical reaction acetyl-CoA + an ... The systematic name of this enzyme class is acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase. Other names in common ... omega-diamine, whereas its two products are CoA and N-acetyldiamine. This enzyme belongs to the family of transferases, ... use include spermidine acetyltransferase, putrescine acetyltransferase, putrescine (diamine)-acetylating enzyme, diamine ...
... is a synthetic menadione analog with vitamin K activity. 2-Methylnaphthalene-1,4-diamine was ... 2-Methylnaphthalene-1,4-diamine and its dihydrochloride can be made from 2-methylnaphthalene or its close analogs. ...
... (EC 1.5.3.14, MPAO, maize PAO) is an enzyme with systematic name spermidine: ... doi:10.1016/0031-9422(96)00316-0. Polyamine+oxidase+(propane-1,3-diamine-forming) at the U.S. National Library of Medicine ... 3-diamine + 4-aminobutanal + H2O2 The products of the reaction cannot be converted directly to other polyamines. Tavladoraki P ... oxygen oxidoreductase (propane-1,3-diamine-forming). This enzyme catalyses the following chemical reaction spermidine + O2 + ...
... (EC 1.5.3.15) is an enzyme with systematic name N8-acetylspermidine: ... N8-acetylspermidine+oxidase+(propane-1,3-diamine-forming) at the U.S. National Library of Medicine Medical Subject Headings ( ... 3-diamine + 4-acetamidobutanal + H2O2 This enzyme is also active n N1-acetylspermine, and it has weak activity on N1,N12- ... oxygen oxidoreductase (propane-1,3-diamine-forming). This enzyme catalyses the following chemical reaction N8-acetylspermidine ...
"Bicyclic Conformationally Restricted Diamines". Chem. Rev. 111 (9): 5506-5568. doi:10.1021/cr100352k. PMID 21711015. S.L. ... "Conformationally restricted monoprotected diamines as scaffolds for design of biologically active compounds and peptidomimetics ...
Springer-Verlag, ISBN 978-3-540-76885-2. (Amino acids, Biochemistry, Diamines). ...
... for conformationally restricted diamines. In the area of nanotechnology, Igor V. Komarov's research group studied cell- ... "Bicyclic Conformationally Restricted Diamines". Chemical Reviews. Vol. 111, no. 9. pp. 5506-5568. doi:10.1021/cr100352k. ISSN ... "Synthesis and Structural Analysis of Angular Monoprotected Diamines Based on Spiro[3.3]heptane Scaffold". The Journal of ... conformationally restricted bicyclic secondary diamines". Molecular Diversity. Vol. 16, no. 3. pp. 477-487. doi:10.1007/s11030- ...
Srivasan Sridhar; Richard G. Carter (2001). "Diamines and Higher Amines, Aliphatic". Kirk-Othmer Encyclopedia of Chemical ...
They are structurally and biosynthetically related to the diamines putrescine and cadaverine. Polyamine metabolism is regulated ... Srivasan Sridhar; Richard G. Carter (2001). "Diamines and Higher Amines, Aliphatic". Kirk-Othmer Encyclopedia of Chemical ...
Srivasan Sridhar; Richard G. Carter (2001). "Diamines and Higher Amines, Aliphatic". Kirk-Othmer Encyclopedia of Chemical ...
... can be synthesized from N,N-dimethyl-N′-phenylethane-1,2-diamine by alkylation with 2-(chloromethyl)thiophene. ... Thenalidine Methapyrilene Leonard F, Solmssen UV (June 1948). "Thenyl Substituted Diamines with Antihistaminic Activity". ... Diamines, H1 receptor antagonists, All stub articles, Respiratory system drug stubs, Sedative stubs). ...
The diamines in PPAs are aliphatic. PA6T homopolymer melts at 371 °C, which renders it intractable. To make usable polymers, it ... Kuraray under the brand Genestar with 9T copolymer (used two isomers of C9 diamine). Mitsui under the brand Arlen with 6T/66 ... is necessary to lower the melting point, which can be achieved practically using either a longer diamine (with 9-12 carbon ...
I. Polymers from fluorene-derived diamines". Journal of Polymer Science Part A: Polymer Chemistry. 14 (1): 225-235. Bibcode: ...
Zeite Abteilung." (A new series of organic diamines. Second part.), Justus Liebigs Annalen der Chemie, 140 : 92-137. [in German ...
"p-Phenylene diamine". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety ...
Addition compounds of boron trifluoride and diamines. Journal of the American Chemical Society (1954), 76 2537-9. Muetterties, ...
Polyether diamines provide good low-temperature flexibility. Piperazine and similar diamines also reduce the number of hydrogen ... Linear aliphatic amines such as ethylene diamine and hexamethylene diamine, provide hardness and strength. Longer chain amines ... Polyamide HMAs are usually composed of a dimer acid with often two or more different diamines. The dimer acid usually presents ... Resistant to plasticizers, therefore suitable for gluing polyvinyl chloride; only polyamides derived from secondary diamines ...
Nguyen, Tien (August 10, 2017). "Electricity jump-starts synthesis of 1,2-diamines". cen.acs.org. Retrieved 2022-05-26. Fu, ... For example, Lin demonstrated an electrochemical approach to synthesize 1,2-diamines from alkenes, which are useful precursors ...
Schiff, Hugo (1866). "Eine neue Reihe organischer Diamine" [A new series of organic diamines]. Annalen der Chemie und Pharmacie ... Schiff, Hugo (1866). "Eine neue Reihe organischer Diamine. Zweite Abtheilung" [A new series of organic diamines. Second part ...
Schiff, Hugo (1866). "Eine neue Reihe organischer Diamine" [A new series of organic diamines]. Annalen der Chemie und Pharmacie ... Schiff, Hugo (1866). "Eine neue Reihe organischer Diamine. Zweite Abtheilung" [A new series of organic diamines. Second part ... Many Schiff base ligands are derived from alkyl diamines and aromatic aldehydes. Schiff base ligands Copper(II) complex of the ...
The diamine also serves as a cross-linking agent in epoxy resins. Hexamethylenediamine is moderately toxic, with LD50 of 792- ... The great majority of the diamine is consumed by the production of nylon 66 via condensation with adipic acid. Otherwise ... Curing of bisphenol a diglycidyl ether with diamines". Journal of Polymer Science: Polymer Symposia. 53 (1): 45-55. doi:10.1002 ... The molecule is a diamine, consisting of a hexamethylene hydrocarbon chain terminated with amine functional groups. The ...
... binding with diamines". Journal of the Chemical Society, Perkin Transactions 1 (14): 1747-1749. doi:10.1039/P19920001747. ISSN ...
The ammonia ligands can be replaced by diamines. Tetracyanonickelate can be replaced by tetracyanopalladate. A wide range of ...
Berberian DA, Slighter RG, Dennis EW (1961). "N,N′-bis(Dichloroacetyl)Diamines as Amebicidal Agents". The American Journal of ... Coulston F, Beyler AL, Drobeck HP (November 1960). "The biologic actions of a new series of bis(dichloroacetyl) diamines". ... Binder M (February 1985). "The teratogenic effects of a bis(dichloroacetyl)diamine on hamster embryos. Aortic arch anomalies ... diamines". Toxicology and Applied Pharmacology. 3: 1-11. doi:10.1016/0041-008x(61)90002-3. PMID 13713106. "Fertilysin". Inxight ...
4-diamine) 5 carbons: cadaverine (pentane-1,5-diamine) Cadaverine 6 carbons: hexamethylenediamine (hexane-1,6-diamine), ... A diamine is an amine with exactly two amino groups. Diamines are used as monomers to prepare polyamides, polyimides, and ... The term diamine refers mostly to primary diamines, as those are the most reactive. In terms of quantities produced, 1,6- ... Vicinal diamines (1,2-diamines) are a structural motif in many biological compounds and are used as ligands in coordination ...
... Combo of electro- and photochemistry allows double C-H activation by Leigh Krietsch ... used a mix of light and electrochemistry to convert neighboring C-H bonds on simple hydrocarbons to cyclic amine and diamine ...
Structure for N,N-dipropylbutane-1,4-diamine. Notice:The structure could not be displayed here becuse JavaScript and a HTML 5 ...
Structure, properties, spectra, suppliers and links for: 3,3-Dimethoxybiphenyl-4,4-diamine, 119-90-4.
US-5801179-A chemical patent summary.
Diamines and Chemicals Limited has received Approval Letter Ref: NSE/LIST/133 on September 21, 2023 from National Stock ... Diamines and Chemicals Limited has received Approval Letter Ref: NSE/LIST/133 on September 21, 2023 from National Stock ... Diamines and Chemicals Limited gets listing approval from NSE. Posted On : 2023-09-22 11:34:24( TIMEZONE : IST ). Diamines and ... Shares of DIAMINES & CHEMICALS LTD. was last trading in BSE at Rs. 526.50 as compared to the previous close of Rs. 527.95. The ...
Elhylene Diamine Tetraacetic Acid Report by Material, Application, and Geography . ... 1.6.1 Elhylene Diamine Tetraacetic Acid Global Import Market Analysis. 1.6.2 Elhylene Diamine Tetraacetic Acid Global Export ... 1.6.3 Elhylene Diamine Tetraacetic Acid Global Main Region Market Analysis. 1.6.4 Elhylene Diamine Tetraacetic Acid Global ... Part I Elhylene Diamine Tetraacetic Acid Industry Overview. Chapter One Elhylene Diamine Tetraacetic Acid Industry Overview. ...
... Molecular Formula: C11H11Cl2N5 ...
... diamines and cyclic organic nitrogen compounds, shown together with the molecular structure of the acids. ... Diamine. 1,6-hexanediamine. 6. 16. 2. 11.86. 10.76. 116.20. Diamine. p-Benzidine. 1,1-biphenyl-4,4-diamine. 12. 12. 2. 1.66. ... Diamine: An amine with two amino groups.. Pyrrole: A heterocyclic aromatic organic compound, a five-membered ring with two ... Amines, diamines and cyclic organic nitrogen compounds - pKa values Values for the negative logarithm of the acid dissociation ...
fact sheet and DIAMINES & CHEM. financial results online at Equitymaster. ... Here is the latest financial fact sheet of DIAMINES & CHEM.. For more details, see the DIAMINES & CHEM. quarterly results and ... DIAMINES & CHEM. Financials. No. of Mths. Year Ending 12. Mar-19*. 12. Mar-20*. 12. Mar-21*. 12. Mar-22*. 12. Mar-23*. 5-Yr ... Read: DIAMINES & CHEM. 2022-23 Annual Report Analysis. More Chemicals & Pesticides Company Fact Sheets: SUPREME PETR BHANSALI ...
Priamine 1075 is a high-purity dimer diamine that can be used as a bio-based modifier of polyamide plastics or co-polyamide ... Priamine 1075 is a high-purity dimer diamine that can be used as a bio-based modifier of polyamide plastics or co-polyamide ...
6-diamine" Detailed information of the J-GLOBAL is a service based on the concept of Linking, Expanding, and Sparking, linking ...
... Molecular Formula: C20H17N3O ... N-acridin-9-yl-2-methoxy-benzene-1,4-diamine N~1~-(9-Acridinyl)-2-methoxy-1,4-benzenediamine 1, 4-Benzenediamine, N1-9- ...
hexamethylene triperoxide diamine 99% Purity from Gentaur Genprice. Reagents in Stock for Immediate Shipment. ...
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
8 New Diamine 150Th Anniversary Ink Colors Coming Soon: Chrissy posted a topic in Th-INKing Outside the Bottle ... This is a fairly quick review, so that I can get up some reviews of the 8 new Diamine inks for you to look at. I havent tried ... I saw no skips or hard starts while I did swabs and dry time tests.It is currently only available in 40ml bottles.Diamine sell ... Ink Review: Diamine Safari (150Th Anniversary Ink) Chrissy posted a topic in Ink Reviews ...
This was further supported by the pronounced chromatin condensation detectable on 4,6-diamine-2-phenylindole dihydrochloride ...
On the Diamine web-site, they only have small swab stripes showing the colours of the Flower Gift Set. So when I ordered Tulip ... Ink Review: Diamine Tulip (One Of The Flowers Gift Set) Chrissy posted a topic in Ink Reviews ... And I didnt buy any, because when I made my way over there, I found this - the Diamine Flower Set. (I thought it wasnt meant ... I always planned to review two reds, Diamine Poppy Red and Tulip next to each other. It saves emptying and cleaning out the ...
80ml Since 1864 Diamine Co. has been manufacturing various fountain pen inks, Calligraphy/ Drawing Ink & Stamp Pads and ... Diamine Midnight can be used with any brand of fountain pens. It comes in a beautiful 80ml glass bottle. ... Experience the beauty of the night with the new Diamine Midnight Ink Bottle. The ink has fast drying properties making it a ...
Silver Diamine Fluoride Receives New FDA Designation. Available at: decisionsindentistry.com/article/silver-diamine-fluoride- ... Silver diamine fluoride (SDF) has been used internationally for years to treat dentinal hypersensitivity and caries lesions.1-3 ... Silver diamine fluoride will stain operatory surfaces, but cleaning products, such as eraser cleaners, have shown success in ... Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese preschool children. ...
Imported from the UK we are proud to offer the full line of Diamine colors in 30mL and 80mL bottles with some colors also being ... The Diamine Ink Co have been ink manufacturers since 1864 and have upheld their reputation for producing the finest quality of ... The Diamine Ink Co have been ink manufacturers since 1864 and have upheld their reputation for producing the finest quality of ... Imported from the UK we are proud to offer the full line of Diamine colors in 30mL and 80mL bottles with some colors also being ...
View the Diamine Fountain Pen Ink 30ml Sunset here. Available at Cass Art. Buy Online Today ... Decrease Quantity of Diamine Fountain Pen Ink 30ml Sunset Increase Quantity of Diamine Fountain Pen Ink 30ml Sunset ... Diamine has a wealth of experience as one of the original English ink makers dating back to 1864. Their fountain pen ink comes ... Diamine fountain pen ink is great for beginners because its water-soluble, allowing for easy erasing, and dries quickly to ...
Imported from the UK we are proud to offer the full line of Diamine colors in 30mL and 80mL bottles with some colors also being ... The Diamine Ink Co have been ink manufacturers since 1864 and have upheld their reputation for producing the finest quality of ... The Diamine Ink Co have been ink manufacturers since 1864 and have upheld their reputation for producing the finest quality of ... Imported from the UK we are proud to offer the full line of Diamine colors in 30mL and 80mL bottles with some colors also being ...
80 ml Diamine Teal Ink Bottle - 80ml. Guranteed for Quality. ... Diamine is first pick for many pen connoisseurs. Every Diamine ... Larger collection of quality fountain pen ink color in the world, Diamine introduces its new Diamine Teal Ink. It is made with ...
Order the Diamine Sherwood Green fountain pen ink from Canadas independent online pen, paper and ink shop. This ink is ...
5Paisa brings you live Diamines & Chemicals stock price along with the stocks fundamentals, technicals, news, company profile, ... Diamines & Chemicals FAQs. What is Share Price of Diamines & Chemicals ? Diamines & Chemicals share price is ₹543 As on 04 ... What is the Market Cap of Diamines & Chemicals ? The Market Cap of Diamines & Chemicals is ₹531.2 Cr As on 04 December, 2023 , ... Diamines & Chemicals Synopsis. BSE-Chemicals-Specialty. Diamines & Chem. is involved in the business activities of Manufacture ...
Order the Diamine Blue Black fountain pen ink from Canadas independent online pen, paper and ink shop. This ink is ...
3-diamine;oxalic acid , C6H17CuN2O5+3 , CID 6395936 - structure, chemical names, physical and chemical properties, ...
Hi! Can I get a quote for a GreenScreen Assessment of Carbanide;nickel;N,N,N,N-tetramethylethane-1,2-diamine [122905-76-4]?. ... Profile for "Carbanide;nickel;N,N,N,N-tetramethylethane-1,2-diamine" on Pharos: https://pharosproject.net/chemicals/2208750 ...
  • Silver diamine fluoride (SDF) has been used internationally for years to treat dentinal hypersensitivity and caries lesions. (dimensionsofdentalhygiene.com)
  • In the oral environment, silver diamine fluoride behaves similarly to silver nitrate, plus fluoride. (dimensionsofdentalhygiene.com)
  • A: Photo before application of silver diamine fluoride (SDF). (dimensionsofdentalhygiene.com)
  • Is Silver Diamine Fluoride the New Sealant? (rdhmag.com)
  • A 2023 study of 3,000 children showed that over a two-year period, glass-ionomer sealants prevented caries 82% of the time, and one drop of silver diamine fluoride (SDF) placed in the pit and fissure sealants prevent 81% of caries. (rdhmag.com)
  • Silver diamine fluoride (SDF) involves fewer steps than traditional sealants, naturally reducing the time it takes for placement. (rdhmag.com)
  • With silver diamine fluoride costing less than other sealant materials, being less time consuming to place, and having similar preventive results, maybe SDF could be a good alternative to a sealant in your practice. (rdhmag.com)
  • This study aimed to evaluate the ability of 38% silver diamine fluoride in remineralisation (as estimated by fluorescence gain) of artificial initial lesions in sm. (uni-marburg.de)
  • The smooth surfaces of 50 human tooth samples were artificially demineralised and 45 samples were allocated randomly into three groups receiving a single treatment with a varnish: group I: Riva Star (silver diamine fluoride, SDF), group II: Bifluorid 12 (NaF, CaF2), and group III: Cervitec F (CHX, CPC, NH4F). (uni-marburg.de)
  • What is Silver Diamine Fluoride? (lamorindatoothbuds.com)
  • Silver diamine fluoride, commonly referred to as SDF, is a liquid that can be brushed onto a tooth that has a cavity. (lamorindatoothbuds.com)
  • Why would Silver Diamine Fluoride be needed? (lamorindatoothbuds.com)
  • To completely halt the spread and progression of decay, silver diamine fluoride can be used. (lamorindatoothbuds.com)
  • Who is a candidate for Silver Diamine Fluoride? (lamorindatoothbuds.com)
  • What happens during the Silver Diamine Fluoride process? (lamorindatoothbuds.com)
  • We then apply a thin layer of liquid silver diamine fluoride to the area. (lamorindatoothbuds.com)
  • Silver diamine fluoride is incredibly effective at killing the bacteria that causes dental caries, and it's a great way to avoid having to get a tooth drilled here at Lamorinda Tooth Buds. (lamorindatoothbuds.com)
  • Objective: To conduct a systematic review on Silver Diamine Fluoride (SDF), reviewing articles published from 1966 to July 2011. (bvsalud.org)
  • including papers written in English, Spanish and Portuguese, which reported on the use of Silver Diamine Fluoride to prevent and arrest caries in deciduous and permanent teeth. (bvsalud.org)
  • Silver Diamine Fluoride Renaissance in Paediatric Dentistry: A 24-Month Retrospective and Cross-Sectional Analysis. (bvsalud.org)
  • Silver diamine fluoride (SDF) has been incorporated into the treatment of dental caries in children , mainly in countries with high caries prevalence . (bvsalud.org)
  • Imported from the UK we are proud to offer the full line of Diamine colors in 30mL and 80mL bottles with some colors also being offered ink international size ink cartridges. (goldspot.com)
  • Ethylenediamine 3 carbons: 1,3-diaminopropane (propane-1,3-diamine) 4 carbons: putrescine (butane-1,4-diamine) 5 carbons: cadaverine (pentane-1,5-diamine) Cadaverine 6 carbons: hexamethylenediamine (hexane-1,6-diamine), trimethylhexamethylenediamine Derivatives of ethylenediamine are prominent: 1,2-diaminopropane, which is chiral. (wikipedia.org)
  • Priamine 1075 is a high-purity dimer diamine that can be used as a bio-based modifier of polyamide plastics or co-polyamide elastomers to make them flexible, even at low temperatures. (adhesivesmag.com)
  • Despite the presence of the bulky branched soft block given by the dimer diamine, all polyimides showed intermolecular charge transfer complexes, whose impact depends on the electronic properties of the dianhydride hard block. (tudelft.nl)
  • This work represents the first detailed report on the development and characterization of polyimides based on a bio-based fatty dimer diamine. (tudelft.nl)
  • or samarium-153-ethylene diamine tetramethylene phosphonate. (medscape.com)
  • The enzyme was found to be inactivated by the metal chelating agent, ethylene diamine tetracetate (EDTA) at 5 X 10-3 and 5 X 10-4 M concentrations. (who.int)
  • Diamines and Chemicals Limited has received Approval Letter Ref: NSE/LIST/133 on September 21, 2023 from National Stock Exchange of India Limited (NSE) for listing of equity shares of the Company on Main Board of NSE. (equitybulls.com)
  • Elhylene Diamine Tetraacetic Acid Report by Material, Application, and Geography Global Forecast to 2023 is a professional and comprehensive research report on the worlds major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, United Kingdom, Japan, South Korea and China). (aarkstore.com)
  • In this report, the global Elhylene Diamine Tetraacetic Acid market is valued at USD XX million in 2023 and is projected to reach USD XX million by the end of 2027, growing at a CAGR of XX% during the period 2023 to 2027. (aarkstore.com)
  • My latest ink samples from Diamine include one of their 150th Anniversary inks: Safari So that's the ink I'm reviewing today. (fountainpennetwork.com)
  • The Diamine Ink Co have been ink manufacturers since 1864 and have upheld their reputation for producing the finest quality of fountain pen inks calligraphy inks drawing inks and writing inks. (goldspot.com)
  • Every Diamine inks are made in United Kingdom. (penboutique.com)
  • Whether you are seeking bright, vibrant hues with dramatic shading or rich, jewel tones with dazzling sheen, DIAMINE fountain pen inks offer an unmatched range of colours to suit your every fancy. (phidonpens.com)
  • Like most Diamine Shimmertastic inks, Red Lustre is gorgeous & rich and it's given me no issues in any of the pens I've inked with it. (penchalet.com)
  • Risk evaluation of occupational exposure to methylene dianiline and toluene diamine in polyurethane foam. (gradientcorp.com)
  • The Diamine Shimmering(50ml) Fountain Pen Ink usually ships within 1-3 business day unless otherwise specified or marked as special order. (penchalet.com)
  • Each Diamine Shimmering(50ml) Fountain Pen Ink we sell is guaranteed to be genuine , authentic and will arrive brand new & unused! (penchalet.com)
  • Values for the negative logarithm of the acid dissociation constant, pKa, of the conjugated acid of amines, diamines and cyclic organic nitrogen compounds, shown together with the molecular structure of the acids. (engineeringtoolbox.com)
  • Vicinal diamines (1,2-diamines) are a structural motif in many biological compounds and are used as ligands in coordination chemistry. (wikipedia.org)
  • This method is a quantitative procedure for the measurement of urinary aromatic diamines using ultra performance liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry (UPLC-APCI-MS/MS). Prior to chromatographic separation, urine samples are hydrolyzed in 0.6 M hydrochloric acid at 80 °C for 4 hours. (cdc.gov)
  • How to improve efficiency of the diamine synthesis from fluorescein? (scienceforums.net)
  • Diamine has a wealth of experience as one of the original English ink makers dating back to 1864. (cassart.co.uk)
  • Diamine ink has been made in England since 1864. (vanness1938.com)
  • Diamines are used as monomers to prepare polyamides, polyimides, and polyureas. (wikipedia.org)
  • A diamine is an amine with exactly two amino groups. (wikipedia.org)
  • Diamine Midnight can be used with any brand of fountain pens. (penboutique.com)
  • Experience the beauty of the night with the new Diamine Midnight Ink Bottle. (penboutique.com)
  • I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
  • Diamine Safari is more green than Salamander, Noodler's VMail Burma Road Brown and Montblanc Racing Green, although it can occasionally look a little more brownish on some papers, depending on the nib used. (fountainpennetwork.com)
  • The characteristics: Feathering None Shading Some Show through Light Wetness High Lubrication Excellent Shimmer/sheen None Price/ml € 0,12 Writer's Blood reminded me most of Diamine Oxblood. (ink-addict.com)
  • Larger collection of quality fountain pen ink color in the world, Diamine introduces its new Diamine Teal Ink. (penboutique.com)
  • Diamine puts out a quality product, and I look forward to using this ink more. (penchalet.com)
  • Create an account below to get 6 C&EN articles per month, receive newsletters and more - all free. (acs.org)
  • The term diamine refers mostly to primary diamines, as those are the most reactive. (wikipedia.org)
  • On the Diamine web-site, they only have small swab stripes showing the colours of the Flower Gift Set. (fountainpennetwork.com)
  • The Diamine Shimmering Fountain Pen Ink comes with small flecks of reflective particles that glisten and shimmer. (penchalet.com)
  • ACS's Premium Package gives you full access to C&EN and everything the ACS Community has to offer. (acs.org)
  • I found the ink a bit more dry than usual from Diamine, but other than that the ink behaved very good. (ink-addict.com)

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