AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
Diabetic AngiopathiesDiabetic RetinopathyDiabetic NephropathiesDiabetes Mellitus, ExperimentalDiabetic FootPregnancy in DiabeticsDiabetes Mellitus, Type 2Diabetes Mellitus, Type 1StreptozocinBlood GlucoseDiabetes MellitusDiabetic CardiomyopathiesDiabetes ComplicationsInsulinDiabetic DietHyperglycemiaHypoglycemic AgentsHemoglobin A, GlycosylatedAlbuminuriaDiabetic ComaMice, Inbred NODGlycosylation End Products, AdvancedRetinal VesselsGlucoseRats, WistarAldehyde ReductaseAlloxanRats, Sprague-DawleyKidneyGlycosuriaIslets of LangerhansRats, ZuckerBody WeightGastroparesisKidney GlomerulusReference ValuesDisease Models, AnimalTime FactorsOxidative StressFructosamineRetinaMice, Inbred C57BLFoot UlcerIslets of Langerhans TransplantationGlucose Tolerance TestBlood-Retinal BarrierRisk FactorsPodocytesBlood Pressure
Diabetic Angiopathies
VASCULAR DISEASES that are associated with DIABETES MELLITUS.
Diabetic Retinopathy
Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Diabetic Nephropathies
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Diabetes Mellitus, Experimental
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Diabetic Foot
Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.
Pregnancy in Diabetics
The state of PREGNANCY in women with DIABETES MELLITUS. This does not include either symptomatic diabetes or GLUCOSE INTOLERANCE induced by pregnancy (DIABETES, GESTATIONAL) which resolves at the end of pregnancy.
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Streptozocin
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Blood Glucose
Glucose in blood.
Diabetes Mellitus
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Diabetic Cardiomyopathies
Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
Diabetes Complications
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Diabetic Diet
A diet prescribed in the treatment of diabetes mellitus, usually limited in the amount of sugar or readily available carbohydrate. (Dorland, 27th ed)
Hyperglycemia
Abnormally high BLOOD GLUCOSE level.
Hypoglycemic Agents
Substances which lower blood glucose levels.
Hemoglobin A, Glycosylated
Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.
Albuminuria
The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
Diabetic Coma
A state of unconsciousness as a complication of diabetes mellitus. It occurs in cases of extreme HYPERGLYCEMIA or extreme HYPOGLYCEMIA as a complication of INSULIN therapy.
Mice, Inbred NOD
A strain of non-obese diabetic mice developed in Japan that has been widely studied as a model for T-cell-dependent autoimmune insulin-dependent diabetes mellitus in which insulitis is a major histopathologic feature, and in which genetic susceptibility is strongly MHC-linked.
Glycosylation End Products, Advanced
Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.
Retinal Vessels
The blood vessels which supply and drain the RETINA.
Glucose
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Rats, Wistar
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Aldehyde Reductase
An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC 1.1.1.21.
Alloxan
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Kidney
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Glycosuria
The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).
Islets of Langerhans
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Rats, Zucker
Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Gastroparesis
Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.
Kidney Glomerulus
A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.
Reference Values
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Oxidative Stress
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Fructosamine
An amino sugar formed when glucose non-enzymatically reacts with the N-terminal amino group of proteins. The fructose moiety is derived from glucose by the "classical" Amadori rearrangement.
Retina
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Mice, Inbred C57BL
Foot Ulcer
Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.
Islets of Langerhans Transplantation
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
Glucose Tolerance Test
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
Blood-Retinal Barrier
A specialized transport barrier, in the EYE, formed by the retinal pigment EPITHELIUM, and the ENDOTHELIUM of the BLOOD VESSELS of the RETINA. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.
Risk Factors
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Podocytes
Highly differentiated epithelial cells of the visceral layer of BOWMAN CAPSULE of the KIDNEY. They are composed of a cell body with major CELL SURFACE EXTENSIONS and secondary fingerlike extensions called pedicels. They enwrap the KIDNEY GLOMERULUS capillaries with their cell surface extensions forming a filtration structure. The pedicels of neighboring podocytes interdigitate with each other leaving between them filtration slits that are bridged by an extracellular structure impermeable to large macromolecules called the slit diaphragm, and provide the last barrier to protein loss in the KIDNEY.
Blood Pressure
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.

Abysmal prognosis of patients with type 2 diabetes entering dialysis. (1/2090)

INTRODUCTION: The importance of non-insulin-dependent diabetes mellitus (type II diabetes) as a leading cause of end-stage renal disease is now widely recognized. The purpose of this study was to assess life-prognosis and its predictors in a cohort of patients newly entering dialysis. MATERIAL AND METHODS: Eighty-four consecutive type II diabetes patients (40% of all patients) starting dialysis between 01/01/95 and 31/12/96 were studied retrospectively, focusing on clinical data at inception and life-prognosis after a mean follow-up of 211 days. Patients were divided into three groups, according to onset of renal failure: acute 11% (9/84), chronic 61% (51/84) and acutely aggravated chronic renal failure 28% (25/84). RESULTS: Patients (mean age 67 years) had long-standing diabetes (mean duration approximately 15 years), heavy proteinuria (approximately 3 g/24h) and diabetic retinopathy (67%). The average creatinine clearance (Cockcroft's formula) was 13 ml/min. Cardiovascular diseases were highly prevalent at the start of dialysis: history of myocardial infarction (26%), angina (36%) and acute left ventricular dysfunction (67%). More than 80% of the patients underwent the first session dialysis under emergency conditions, a situation in part related to late referral to the nephrology division (63% for chronic patients). A great majority of the patients were overhydrated when starting dialysis, as evidenced by the average weight loss of 6 kg, during the first month of dialysis, required to reach dry weight. Nearly 64% of the patients presented high blood pressure (> 140/90 mmHg) when starting dialysis despite antihypertensive therapy (mean: 2.3 drugs). The outcome of this type II diabetes population was dramatic: 32% (27/84) died after a mean follow-up of 211 days, mostly from cardiovascular diseases. The rate of recovery of renal function was low in both the acute and the acutely aggravated renal failure group (30% and 24%, respectively). Of note, iatrogenic nephrotoxic agents accounted for renal function impairment in nearly 30% of patients. CONCLUSION: Our observational study illustrates the high burden of cardiovascular diseases contrasting with sub-optimal cardiovascular therapeutic interventions in type II diabetes patients entering dialysis. Factors aggravating renal failure were mainly iatrogenic, and therefore largely avoidable. Late referral generally implied a poor clinical condition at the start of dialysis.  (+info)

Paraoxonase 192 Gln/Arg gene polymorphism, coronary artery disease, and myocardial infarction in type 2 diabetes. (2/2090)

Paraoxonase is an HDL-associated enzyme implicated in the pathogenesis of atherosclerosis by protecting lipoproteins against peroxidation. Its biallelic gene polymorphism at codon 192 (glutamine/arginine) has been associated with coronary artery disease (CAD). To further evaluate the role of this paraoxonase gene polymorphism for CAD in type 2 diabetes, we determined the paraoxonase genotype in 288 type 2 diabetic patients (170 with and 118 without angiographically documented CAD). The paraoxonase 192 Gln/Arg genotype was assessed using polymerase chain reaction followed by AlwI digestion. The frequency of the Gln allele was 0.656 in the CAD patients and 0.746 in the controls (chi2 = 5.36, P = 0.02). Compared with the Gln/Gln genotypes, the age-adjusted odds ratio for CAD was 1.78 (95% CI 1.08-2.96, P = 0.02) in subjects carrying at least one Arg allele. In the multivariate analysis, this association was even stronger after correction for the possible confounders age, sex, smoking history, and hypertension. Among current and former smokers, the odds ratio (OR) for having CAD among patients with at least one Arg allele was 3.58 (1.45-9.53, P < 0.01). The paraoxonase Arg allele was not associated with the history of myocardial infarction (OR 1.20 [0.73-1.99, NS]), but was with the extent of CAD (OR for three-vessel disease 1.92 [1.15-3.27, P = 0.01]). Our data indicate that the 192 Arg allele of the human paraoxonase gene is a risk factor for CAD but not myocardial infarction in type 2 diabetic patients, a risk factor further modified by cigarette smoking. This risk could possibly be explained by a reduced ability of the paraoxonase Arg isoform to protect lipoproteins against peroxidation.  (+info)

Role of systolic blood pressure and plasma triglycerides in diabetic peripheral arterial disease. The Edinburgh Artery Study. (3/2090)

OBJECTIVE: To determine the risk factors for peripheral arterial disease (PAD) in a diabetic population and to examine whether different levels of these risk factors might explain why diabetic subjects have an increased risk of PAD compared with normal glucose tolerance subjects. RESEARCH DESIGN AND METHODS: There were 1,592 men and women aged 55-74 years selected at random from the age-sex registers of 11 general practices in Edinburgh, Scotland. Subjects underwent a comprehensive medical examination, including assessment for PAD (intermittent claudication on World Health Organization questionnaire or major asymptomatic disease on noninvasive testing) and a glucose tolerance test. RESULTS: Of the subjects, 288 (18.7%) were found to have diabetes or impaired glucose tolerance (IGT). The prevalence of PAD was greater in those with diabetes/IGT (20.6%) compared with those with normal glucose tolerance (12.5%) (odds ratio [OR] 1.64, 95% CI 1.17-2.31). Among the diabetes/IGT group, mean levels of smoking, systolic blood pressure, and triglycerides were higher in subjects with PAD than in those without PAD (P < or = 0.05). Mean levels of systolic blood pressure and plasma triglycerides were also higher in diabetic subjects than in nondiabetic subjects with PAD (P < or = 0.05). In multivariate analysis, those with diabetes/IGT no longer had a significantly higher risk of PAD after adjusting separately for systolic blood pressure (OR 1.22, 95% CI 0.85-1.73) and plasma triglycerides (OR 1.26, 95% CI 0.89-1.79). Simultaneous adjustment for both systolic blood pressure and triglycerides reduced the risk of PAD among diabetic subjects to 1.11 (95% CI 0.78-1.58). CONCLUSIONS: Increased mean levels of triglycerides and systolic blood pressure may help to explain the higher prevalence of PAD in diabetic subjects compared with that in normal glucose tolerance subjects.  (+info)

Increased frequency of G-protein beta 3-subunit 825 T allele in dialyzed patients with type 2 diabetes. (4/2090)

BACKGROUND: A polymorphism (C825T) in exon 10 of the gene encoding the beta 3 subunit of heterotrimeric G proteins (GN beta 3) has recently been described, and the T allele was found to be associated with late-onset hypertension. Because hypertension is a known risk factor for the development of clinically manifest progressive renal disease, we examined the C825T polymorphism in older hemodialysis patients suffering from nondiabetic renal disease or type 2 diabetes with presumed diabetic nephropathy, respectively, and in older healthy controls. METHODS: Genotyping was performed by polymerase chain reaction, followed by restriction enzyme analysis. RESULTS: The study showed that the frequency of the T allele in the nondiabetic patients on dialysis (0.232) was significantly (P < 0.03) lower than in older healthy controls (0.293). In contrast, the frequency was significantly (P < 0.02) higher in older patients with type 2 diabetes on dialysis. No significant change in T-allele frequency was noted in older patients with type 2 diabetes without microangiopathy (0.286). The odds ratios for patients with type 2 diabetes on dialysis versus nondiabetic patients on dialysis were 3.24 (1.3 to 7.9, P < 0.00079) for TT/CC and 1.82 (1.07 to 3.09, P < 0.02) for CT/CC. The respective odds ratios for patients with type 2 diabetes on dialysis versus controls were 2.05 (1.07 to 3.9, P < 0.028) for CT/CC and 1.216 (0.79 to 1.87; P < 0.37) for CT/CC. CONCLUSION: The data do not support a role of the hypertension-associated T allele in the genesis of dialysis-dependent end-stage renal failure in general, but are compatible with a specific role of the T allele in the development or progression of diabetic nephropathy.  (+info)

Hypertension in diet versus pharmacologically treated diabetics: mortality over a 5-year follow-up. (5/2090)

The natural history of non-insulin-dependent diabetes mellitus (NIDDM) differs markedly between patients with diet treated and pharmacologically treated disease. However, the interrelationship between hypertension and these common diabetes types has not been specifically addressed in previous studies. This study was designed to evaluate the prognostic significance and prevalence of hypertension in coronary patients with diet versus pharmacologically treated NIDDM over a 5-year follow-up period. The study sample comprised 11 515 patients aged 45 to 74 years with a previous myocardial infarction and/or anginal syndrome who had been screened but were not included in the Bezafibrate Infarction Prevention study. Among them, 9033 were nondiabetics and 2482, diabetics (987 diet treated and 1495 pharmacologically treated). The prevalence of hypertension among nondiabetics, diet-treated diabetics, and pharmacologically treated diabetics was 31%, 42%, and 43%, respectively. Crude all-cause mortality (CM) was lower in the nondiabetic patients (11.2% versus 22.0%; P<0.001). Among diabetics, 548 patients died: 81 diet treated normotensives (CM 14%); 100 diet-treated hypertensives (CM 24.4%); 205 pharmacologically treated normotensives (CM 24.2%); and 162 pharmacologically treated hypertensive patients (CM 25.0%). Age-adjusted mortality was lowest for the normotensive patients in the diet-treated group and highest for the hypertensive pharmacologically treated patients. Multivariate analysis shows that hypertension is a strong and independent predictor of increased CM in diet-treated but not in pharmacologically treated NIDDM: hazard ratio (HR) was 1.68 (95% confidence interval [CI] 1.24 to 2.29) for the diet-treated versus 1. 01 (95% CI 0.82 to 1.26) for the pharmacologically treated diabetics. The contribution of hypertension to stroke mortality was substantial for both diet treated and pharmacologically treated NIDDM: hazard ratios were 3.17 (95% CI 1.12 to 8.98) and 2.21 (95% CI 0.72 to 6.77), respectively. The increased risk of mortality associated with hypertension in relatively mild diet-treated NIDDM strongly supports the clinical benefit of early blood pressure control among diabetic patients with ischemic heart disease.  (+info)

The Trp64Arg amino acid polymorphism of the beta3-adrenergic receptor gene does not contribute to the genetic susceptibility of diabetic microvascular complications in Caucasian type 1 diabetic patients. (6/2090)

OBJECTIVE: The beta3-adrenergic receptor is involved in regulation of microvascular blood flow. A missense mutation (Trp64Arg) in the beta3-adrenergic receptor gene has been suggested as a risk factor for proliferative retinopathy in Japanese type 2 diabetic patients. The aim of the present study was to evaluate the contribution of this polymorphism to the development of microangiopathic complications in Caucasian type 1 diabetic patients. SUBJECTS AND METHODS: We studied the relationship between the Trp64Arg polymorphism in type 1 diabetic patients with nephropathy (204 men/132 women, age 42.8 +/- 11.0 years, diabetes duration 28 +/- 9 years) and in type 1 diabetic patients with persistent normoalbuminuria (118 men/73 women, age 42.6 +/- 10.2 years, diabetes duration 27 +/- 8 years). Proliferative retinopathy was present in 254 patients (48%), while 66 patients (13%) had no diabetic retinopathy. RESULTS: There were no differences in Trp64Arg genotype distribution between type 1 diabetic patients with diabetic nephropathy and type 1 diabetic patients with normoalbuminuria: 295 (88%)/38 (11%)/3 (1%) vs 161 (84%)/30 (16%)/- had Trp/Trp, Trp/Arg or Arg/Arg genotype respectively. Odds ratio (95% CI) of nephropathy in carriers of the mutation was 0.75 (0.45-1.25). No associations between the Trp64Arg polymorphism and simplex or proliferative retinopathy were revealed either. The frequency of the Arg-allele was 0.069 in patients with proliferative retinopathy, 0.066 in patients with simplex retinopathy and 0.090 in patients with no signs of diabetic retinopathy, NS. CONCLUSIONS: The Trp64Arg polymorphism of the beta3-adrenergic receptor gene does not contribute to the genetic susceptibility to diabetic nephropathy in Caucasian type 1 diabetic patients. Nor does our study support previous findings of an association between this variant and proliferative retinopathy.  (+info)

Influence of diabetes on revascularisation procedures of the aorta and lower limb arteries: early results. (7/2090)

OBJECT: to evaluate the influence of diabetes mellitus on the therapeutic indications and the one-month results in patients with occlusive disease of the aorta and/or lower limbs arteries. MATERIAL: a retrospective study of fully computerised data of 1003 patients (753 men, 250 women) admitted consecutively to our vascular surgery unit over a 5-year period (1992-1996). Of the total, 169 were diabetics (group I) and 834 were non-diabetics (group II). Sixty-two per cent of patients in group I vs. 40% in group II presented with critical ischaemia or trophic changes (p<0.001). RESULTS: 15.4% of patients in group I vs. 4.1% in group II had primary amputation because of irreversible ischaemia or because arterial reconstruction was impossible. Of those who underwent revascularisation, 80% were infrainguinal in group I vs. 50% in group II. Forty-five per cent of patients in group I and 37% in group II had a percutaneous transluminal angioplasty (PTA) and approximately 3% in both groups had a combination of the two techniques. At one month, patients alive without major amputation numbered 64.4% in group I vs. 93.6% in group II, patients alive with major amputation numbered 26.6% in group I vs. 5.5% in group II, and mortality rates were 8.9% in group I vs. 0.8% in group II (P<0.001). CONCLUSIONS: the 5-times higher amputation and 10-times higher mortality rates for diabetics compared to non-diabetics call for better collaborative management of diabetics between general practitioners, vascular surgeons, diabetologists and cardiologists. PTA with a 90% initial success rate is indicated for short lesions even in the presence of limited gangrene.  (+info)

Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation state. (8/2090)

Maternal diabetes mellitus is associated with an increased incidence of congenital abnormalities as well as embryonic and perinatal lethality. In particular, a wide range of cardiovascular abnormalities have been noted in children of diabetic mothers and in the offspring of diabetic animals. The vascular system is the first organ system to develop in the embryo and is critical for normal organogenesis. The organization of mesodermal cells into endothelial and hematopoietic cells and into a complex vascular system is, in part, mediated by a series of specific cell-cell, cell-extracellular matrix, and cell-factor interactions. PECAM-1 expression has been observed during the earliest stages of vasculogenesis, and changes in PECAM-1 tyrosine phosphorylation have been associated with endothelial cell migration, vasculogenesis, and angiogenesis both in vitro and in vivo. In this report we demonstrate that exposure to hyperglycemia during gastrulation causes yolk sac and embryonic vasculopathy in cultured murine conceptuses and in the conceptuses of streptozotocin-induced diabetic pregnant mice. In addition, we correlate the presence of yolk sac and embryonic vasculopathy with the failure of PECAM-1 tyrosine dephosphorylation during the formation of blood islands/vessels from clusters of extra-embryonic and embryonic angioblasts in the murine conceptus using both in vitro and in vivo models. The importance of these findings in the development of vasculopathy in the offspring of diabetic mothers and the potential effects and benefits of glucose regulation during the periods of vasculogenesis/angiogenesis in embryonic development are discussed.  (+info)

An Experimental study of Macroangiopathy, a common complication of Diabetes Mellitus, with Ayurveda perspectiveAn Experimental study of Macroangiopathy, a common complication of Diabetes Mellitus, with Ayurveda perspective
An Experimental study of Macroangiopathy, a common complication of Diabetes Mellitus, with Ayurveda perspective Prof. Ojha S. N. M.D.(Ayu.) Ph.D. Principal Dr. D.Y Patil college of ayurved and research centre Pimpri pune 18 . ► The prevalence of macroangiopathy is increased in Diabetes Mellitus. ► Endothelial cell injury is thought to be an early event leading to atherosclerosis…
https://drojha.wordpress.com/2012/01/12/an-experimental-study-of-macroangiopathy-a-common-complication-of-diabetes-mellitus-with-ayurveda-perspective/
Macrovascular disease - WikipediaMacrovascular disease - Wikipedia
Macrovascular disease is a disease of any large (macro) blood vessels in the body. It is a disease of the large blood vessels, including the coronary arteries, the aorta, and the sizable arteries in the brain and in the limbs. This sometimes occurs when a person has had diabetes for an extended period of time. Fat and blood clots build up in the large blood vessels and stick to the vessel walls. Three common macrovascular diseases are coronary disease (in the heart), cerebrovascular disease (in the brain), and peripheral vascular disease (in the limbs) Macrovascular disease (macroangiopathy) refers to atherosclerosis. Atherosclerosis is a form of arteriosclerosis (thickening and hardening of arterial walls), characterized by plaque deposits of lipids, fibrous connective tissue, calcium, and other blood substances. Atherosclerosis, by definition, affects only medium and large arteries (excluding arterioles). Macrovascular disease is associated with the development of coronary artery disease, ...
https://en.wikipedia.org/wiki/Macrovascular_disease
Stroke in Diabetic Patients: Is It Really a Macrovascular Complication? | StrokeStroke in Diabetic Patients: Is It Really a Macrovascular Complication? | Stroke
To the Editor:. We have read with interest the article by Wilcox et al,1 in which they demonstrated the positive effect of pioglitazone on stroke recurrence in patients with type 2 diabetes mellitus (DM). However, we would like to stress a particular concern regarding a basic concept in the difficult question of DM and stroke. In this study, as in other previous studies, stroke is considered a macrovascular event in diabetic patients, but is this statement true? Traditionally, retinopathy, neuropathy, and nephropathy have been designated microvascular complications of DM, and stroke, myocardial infarction and gangrene are termed macrovascular complications.2 However, we think it is time to change this commonly accepted concept.. The pathophysiology of cerebrovascular disease in patients with DM is not fully characterized, but both large and small blood vessels seem to be affected. Thus, the etiology of strokes in diabetics is frequently microvascular disease from fibrinoid necrosis, which causes ...
http://stroke.ahajournals.org/content/38/10/e106
Effect of olmesartan on beta-cell function and diabetic angiopathy in type 2 diabeteic patients with hypertension - AdisInsightEffect of olmesartan on beta-cell function and diabetic angiopathy in type 2 diabeteic patients with hypertension - AdisInsight
This study will compare the effects of olmesartan medoxomil and amlodipine on beta-cell function and the incidence diabetic angiopathy in type 2 diabetic
http://adisinsight.springer.com/trials/700208845?error=cookies_not_supported&code=d66a3d82-431a-40ce-ace7-509e734dea19
Symptoms of Microvascular Complications of Diabetes, Susceptibility to, 2 - RightDiagnosis.comSymptoms of Microvascular Complications of Diabetes, Susceptibility to, 2 - RightDiagnosis.com
Symptoms of Microvascular Complications of Diabetes, Susceptibility to, 2 including 5 medical symptoms and signs of Microvascular Complications of Diabetes, Susceptibility to, 2, alternative diagnoses, misdiagnosis, and correct diagnosis for Microvascular Complications of Diabetes, Susceptibility to, 2 signs or Microvascular Complications of Diabetes, Susceptibility to, 2 symptoms.
http://www.rightdiagnosis.com/m/microvascular_complications_of_diabetes_susceptibility_to_2/symptoms.htm
Serum Kallistatin is Increased in Type 2 Diabetic Patients with Microvascular Complications and Correlates with the Presence of...Serum Kallistatin is Increased in Type 2 Diabetic Patients with Microvascular Complications and Correlates with the Presence of...
Purpose: : Human kallistatin is a secreted, glycoprotein and a serine proteinase inhibitor that specifically binds to tissue kallikrein, and it has multiple functions, e.g., anti-angiogenic, anti-fibrogenic, anti-inflammatory, and anti-oxidative activities independent of its direct tissue kallikrein inhibition. It is produced mostly by the liver, but is also secreted by the retina and blood vessels. Human kallistatin is decreased in the vitreous space of diabetics with retinopathy versus that in controls. Recently, our group reported that serum kallistatin is significantly elevated in type 1 diabetic patients with microvascular complications, compared to non-diabetic controls or diabetic patients without complications. Our hypothesis is that average serum kallistatin may be increased in the sera of type 2 diabetic patients compared to non-diabetic controls and type 2 patients without microvascular complications. Methods: : We collected serum samples from patients at the University of Oklahoma ...
http://iovs.arvojournals.org/article.aspx?articleid=2351894
Peripheral arterial disease: diagnosis and management | NICEPeripheral arterial disease: diagnosis and management | NICE
Why this is important:- Many people with critical limb ischaemia, especially those with diabetic vascular disease, also have disease of the infra-geniculate (below the knee) arteries in the calf. For many years, the standard of care has been bypass surgery. Although such surgery may be associated with significant morbidity, the resulting long-term amputation-free survival rates are generally good. In recent years there has been a trend towards treating infra-geniculate disease with angioplasty, on the grounds that it is associated with less morbidity than surgery. However, this change in practice is not evidence-based, and serious concerns remain about the durability of angioplasty in this anatomical area. A multicentre, randomised controlled trial with a full health economic analysis is required to address this. The primary endpoint should be amputation-free survival, with secondary endpoints including overall survival, health-related quality of life, healing of tissue loss, and relief of ...
https://www.nice.org.uk/about/what-we-do/research-and-development/research-recommendations/cg147/1
可降低2型糖尿病患者心血管风险的降糖药 - NEJM医学前沿可降低2型糖尿病患者心血管风险的降糖药 - NEJM医学前沿
1. Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th ed. Diabetes Res Clin Pract 2019;157:107843-107843.. 2. Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999;104:787-794.. 3. American Diabetes Association. 10. Cardiovascular disease and risk management: Standards of medical care in diabetes-2021. Diabetes Care 2021;44:Suppl 1:S125-S150.. 4. Das SR, Everett BM, Birtcher KK, et al. 2020 expert consensus decision pathway on novel therapies for cardiovascular risk reduction in patients with type 2 diabetes: a report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol 2020;76:1117-1145.. 5. Orasanu G, Plutzky J. The pathologic continuum of diabetic vascular disease. J Am Coll ...
https://nejmqianyan.cn/article/YXQYcp2000280
British Library EThOS: Glucose as a signalling molecule in microvascular complications and loss of β-cell viability in diabetesBritish Library EThOS: Glucose as a signalling molecule in microvascular complications and loss of β-cell viability in diabetes
Prolonged exposure to hyperglycaemia may contribute to the development of microvascular complications and loss of ~-cell viability in diabetes. In the past decade it has become clear that glucose itself acts as a signalling molecule via the induction of candidate genes which contribute to the disease process. ChREBP is a glucose responsive transcription factor with a response element in the promoter region of various genes, and is one of the targets through which glucose exerts its effect on gene expression. Both aldose reductase and thioredoxin interacting protein are under ChREBP mediated, glucose dependent regulation. Aldose reductase has been indicated in the process of diabetic complications, whereas the TXNIP protein is described as a central proapoptotic factor in the loss of ~-cell viability and is also emerging as a candidate gene for microvascular complication of diabetes. The current study has investigated the role of ChREBP, AR and TXNIP in these disease processes by collecting PBMCs ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.573112
The influence of antioxidant therapy for transdermal effort of oxygen in patients with diabetic angiopathy of lower extremitiesThe influence of antioxidant therapy for transdermal effort of oxygen in patients with diabetic angiopathy of lower extremities
Diabetes mellitus (DM) is one of the commonest global noncommunicable health-care problem, carrying a predicted pandemic score of 366 million population by 2030.
https://www.thepharmajournal.com/archives/?year=2018&vol=7&issue=3&ArticleId=1729
Treatment strategy for type 2 diabetes from the perspective of systemi | VHRMTreatment strategy for type 2 diabetes from the perspective of systemi | VHRM
Treatment strategy for type 2 diabetes from the perspective of systemic vascular protection and insulin resistance Kazunori UtsunomiyaDivision of Diabetes, Metabolism and Endocrinology, Jikei University School of Medicine, Tokyo, JapanAbstract: This paper provides an update on the mechanisms of vascular impairment associated with insulin resistance and the pathogenesis of diabetic nephropathy and peripheral artery disease (PAD). It also considers the optimal treatment strategies for systemic vascular protection in light of recent findings. This area is of major clinical importance given the ongoing global epidemic of type 2 diabetes and the pivotal role played by insulin resistance in the mechanism of vascular impairment that manifests as macroangiopathy and microangiopathy. Timely diagnosis and intervention is critical in patients with systemic arteriosclerotic disease. Therefore, treatment strategies are aimed not only at targeting the presenting pathology, but also at reducing the risk of
https://www.dovepress.com/treatment-strategy-for-type-2-diabetes-from-the-perspective-of-systemi-peer-reviewed-article-VHRM
Prognosis of Microvascular Complications of Diabetes, Susceptibility to, 7 - RightDiagnosis.comPrognosis of Microvascular Complications of Diabetes, Susceptibility to, 7 - RightDiagnosis.com
Prognosis of Microvascular Complications of Diabetes, Susceptibility to, 7 including probable outcomes, duration, recurrence, complications, deaths, and survival rates.
http://www.rightdiagnosis.com/m/microvascular_complications_of_diabetes_susceptibility_to_7/prognosis.htm
Intriguingly, these mechanisms resemble people dependable for the progression of macrovascular complications these kinds of as...
Intriguingly, these mechanisms resemble those accountable for the development of macrovascular problems this sort of as atherosclerosis. Consequently,RO4929097
http://www.hatsinhibitor.com/2015/11/30/intriguingly-these-mechanisms-resemble-people-dependable-for-the-progression-of-macrovascular-complications-these-kinds-of-as-atherosclerosis/
Plus itPlus it
Hypertension and dyslipidemia, among other risk factors for CVD, are common in subjects with diabetes. Together, they can explain most, but not all, of the excess of risk of CVD in patients affected by the disease. High blood glucose has long been considered a risk factor for developing atherosclerosis, but data directly relating this alteration to the development and progression of CVD are conflicting. In this context, several glucose-lowering trials in both type 1 and type 2 diabetes showing significant reductions in microvascular complications have systematically failed to achieve significant reductions in macrovascular events (5). Nevertheless, it should also be mentioned that some systematic reviews and metanalysis performed in type 1 and type 2 diabetes (in the case of type 1 diabetes including some studies with few subjects and none or very small number of CV events) have suggested that attempts to improve glycemia reduce the incidence of CVD (9,10).. Before going through proper trials ...
http://care.diabetesjournals.org/content/32/suppl_2/S334
Plus itPlus it
In this study, we show for the first time that sitagliptin increases EPCs in type 2 diabetic patients, as an ancillary effect of DPP-4 inhibition, possibly mediated by the SDF-1α/CXCR4 axis.. Experimental studies demonstrate that EPCs stimulate endothelial repair and angiogenesis (1). These cells are reduced in diabetic patients at an early stage and are further impaired in patients with macro-/microvascular complications (2,8,9). Low baseline progenitor cell levels predict adverse outcomes of macro- and microangiopathy (3,4,10), and EPC reduction is now considered a novel route to development and worsening of diabetes complications. In response to ischemia, SDF-1α is upregulated and, upon binding to its receptor CXCR4, stimulates the bone marrow to release EPCs that are eventually recruited at ischemic sites (7). In diabetic animals a blunted SDF-1α response to ischemia is associated with inhibited progenitor cell release from the bone marrow and defective postischemic angiogenesis (11). ...
http://care.diabetesjournals.org/content/33/7/1607
Portal Saúde Direta - Protocolos
Recent estimates indicate there were 171 million people in the world with diabetes in the year 2000 and this is projected to increase to 366 million by 2030-. Diabetes is a condition primarily defined by the level of hyperglycaemia giving rise to risk of microvascular damage (retinopathy, nephropathy and neuropathy). It is associated with reduced life expectancy, significant morbidity due to specific diabetes related microvascular complications, increased risk of macrovascular complications (ischaemic heart disease, stroke and peripheral vascular disease), and diminished quality of life ...
http://saudedireta.com.br/protocolos.php?id=2896
My Site - Chapter 8: Targets for Glycemic ControlMy Site - Chapter 8: Targets for Glycemic Control
Therapy in most individuals with type 1 or type 2 diabetes should be targeted to achieve an A1C ≤7.0% in order to reduce the risk of microvascular [Grade A, Level 1A (1,2) ] and, if implemented early in the course of disease, macrovascular complications [Grade B, Level 3 (3,4) ...
http://guidelines.diabetes.ca/executivesummary/ch8
Clinical value and severity of myocardial perfusion defects in asymptomatic diabetic patients with negative or weakly positive...Clinical value and severity of myocardial perfusion defects in asymptomatic diabetic patients with negative or weakly positive...
Objective: Although coronary artery disease (CAD) is the leading cause of death in type 2 diabetic patients, it is frequently asymptomatic. Myocardial perfusion imaging (MPI) is reported to show ischemia in a significant number of asymptomatic diabetic patients. We studied the prevalence and severity of myocardial perfusion defects in asymptomatic diabetic patients and its clinical impact. Methods and patients: One hundred thirty consecutive asymptomatic patients, aged 35-65 years with type 2 diabetes mellitus and with no history of CAD and no cardiac symptoms were recruited in the study. Echocardiography, electrocardiography (ECG), routine laboratory tests and exercise treadmill test (ETT) were performed and patients with weakly positive or negative ETT underwent Dipyridamole MPI. Patients with positive ETT were referred to coronary angiography. Patients were followed for at least 17 months (mean 21.7 months) and any cardiac event was recorded. Results: We studied 81 female and 49 male patients with
http://aojnmb.mums.ac.ir/article_603.html
Medical therapy and diabetic microvascular disease Archives - Iacapap
Diabetic microvascular disease The 3 main manifestations of diabetic microvascular disease, retinopathy, nephropathy, and neuropathy are reviewed.. Retinopathy: Diabetic microvascular disease is strongly associated with hyperglycemia. In the range of chronic hyperglycemia commonly seen in practice, there is an 11-fold increase in retinopathy compared to a 2-fold increase in coronary artery disease. Despite the importance of hyperglycemia, some patients may develop early evidence of retinopathy up to 7 years before the development of Franks type 2 diabetes mellitus, indicating the contribution of insulin resistance.. In addition to the severity of hyperglycemia and the duration of diabetes mellitus, other factors associated with retinopathy include hypertension, smoking, and dyslipidemia. These and other pathophysiological mechanisms, including insulin resistance and inflammation, contribute to the diabetic microvascular disease process.. The early histopathological sign of retinopathy related ...
https://iacapap2006.com/tag/medical-therapy-and-diabetic-microvascular-disease/
Diabetic Microvascular Complications | Endocrinology
Diabetic Microvascular Complications are 3 main manifestations of microvascular disease, retinopathy, nephropathy, and neuropathy are reviewed.
https://iacapap2006.com/general-topics/diabetic-microvascular-complication/
Red blood cell count as an indicator of microvascular complications in | VHRMRed blood cell count as an indicator of microvascular complications in | VHRM
Red blood cell count as an indicator of microvascular complications in Chinese patients with type 2 diabetes mellitus Zhan-Sheng Wang,1,2 Zhan-Chun Song,1 Jing-Hui Bai,1 Fei Li,3 Tao Wu,1 Ji Qi,2 Jian Hu11Department of Cardiology, First Affiliated Hospital of China Medical University, 2Second Department of Cardiology, Fourth People's Hospital of Shenyang, Shenyang, 3Department of Cardiology, Shenzhou Hospital of Shenyang Medical College, Shenyang, People's Republic of ChinaBackground: Rheological disorders of red blood cells (RBC) and decreased RBC deformability have been involved in the development of diabetic microangiopathy. However, few studies have evaluated the association of RBC count with microvascular complications in patients with type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the association of RBC count with microvascular complications in patients with T2DM.Methods: This study involved 369 patients with T2DM: 243 with one or more microvascular
https://www.dovepress.com/red-blood-cell-count-as-an-indicator-of-microvascular-complications-in-peer-reviewed-article-VHRM
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective...
The UK prospective diabetes study (UKPDS), a clinical trial of a policy of intensive control of blood glucose after diagnosis of type 2 diabetes, which achieved a median haemoglobin A1c (HbA1c) of 7.0% compared with 7.9% in those allocated to conventional treatment over a median 10.0 years of follow up, has shown a substantial reduction in the risk of microvascular complications, with a reduction in the risk of myocardial infarction of borderline significance.1 Complementary information for estimates of the risk of complications at different levels of glycaemia can be obtained from observational analyses of data during the study.. In patients with type 2 diabetes previous prospective studies have shown an association between the degree of hyperglycaemia and increased risk of microvascular complications, 2 3 sensory neuropathy, 3 4 myocardial infarction, 2 5 6 stroke,7 macrovascular mortality,8-10 and all cause mortality. 9 11-14 Generally, these studies measured glycaemia as being high or low or ...
https://www.bmj.com/content/321/7258/405?ijkey=7a56ce80ddea8af7b301e9ff7b3493c7d02cf2c7&keytype2=tf_ipsecsha
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective...
The UK prospective diabetes study (UKPDS), a clinical trial of a policy of intensive control of blood glucose after diagnosis of type 2 diabetes, which achieved a median haemoglobin A1c (HbA1c) of 7.0% compared with 7.9% in those allocated to conventional treatment over a median 10.0 years of follow up, has shown a substantial reduction in the risk of microvascular complications, with a reduction in the risk of myocardial infarction of borderline significance.1 Complementary information for estimates of the risk of complications at different levels of glycaemia can be obtained from observational analyses of data during the study.. In patients with type 2 diabetes previous prospective studies have shown an association between the degree of hyperglycaemia and increased risk of microvascular complications, 2 3 sensory neuropathy, 3 4 myocardial infarction, 2 5 6 stroke,7 macrovascular mortality,8-10 and all cause mortality. 9 11-14 Generally, these studies measured glycaemia as being high or low or ...
https://www.bmj.com/content/321/7258/405?ijkey=b7fece7b955573c5c1eafb92b65caa900b5d5559&keytype2=tf_ipsecsha
To Investigate the Effect of Rosiglitazone and Ramipril on Pre-clinical Vasculopathy in Diabetes and IGT Patients - Full Text...To Investigate the Effect of Rosiglitazone and Ramipril on Pre-clinical Vasculopathy in Diabetes and IGT Patients - Full Text...
The burden of diabetic vasculopathy on the global population is enormous and ever growing. Besides the well-known microvascular complications in type 2 diabetes (T2DM), there is a growing epidemic of macrovascular complications. People with T2DM have a higher risk of death from cardiovascular (CV) diseases than persons without diabetes. Like diabetes, impaired glucose tolerance (IGT) individuals also have associated risk of developing macrovascular complications. This calls for an early detection and intervention in patients with T2DM as well as IGT, not only to delay progression of IGT to T2DM but also to treat early macrovascular diseases in both groups. The traditional therapeutic approaches of T2DM emphasise on glycaemic control, which limits microvascular diseases but lacks an established benefit in macrovascular diseases. Type 2 diabetes is a metabolic disorder characterised by dyslipidaemia, hypertension, and hypercoagulability in addition to hyperglycaemia and hyperinsulinaemia. Each of ...
https://clinicaltrials.gov/ct2/show/NCT00489229?cond=%22Diabetic+Angiopathies%22&rank=8
UK Prospective Diabetes Study. XII: Differences between Asian, Afro-Caribbean and white Caucasian type 2 diabetic patients at...
Clinical and biochemical variables and prevalence of complications at diagnosis of diabetes were assessed in 5098 Type 2 diabetic patients in the UK Prospective Diabetes Study of whom 82% were white Caucasian, 10% Asian of Indian origin, and 8% Afro-Caribbean. The Asian patients were (p | 0.001) younger (mean age 52.3, 47.0, 51.0 years), less obese (BMI 29.3, 26.7, 27.9 kg m-2), had a greater waist-hip ratio, lower blood pressure (systolic 145, 139, 144, diastolic 87, 86, 89 mmHg) and prevalence of hypertension. They were more often sedentary (19, 39, 15%), more often abstained from alcohol (21, 55, 25%) and had a greater prevalence of first degree relatives with known diabetes (36, 44, 34%). The Afro-Caribbean patients had (p | 0.001) higher fasting plasma glucose (11.9, 11.3, 12.5 mmol l-1), more severely impaired beta-cell function (45, 35, 28% normal) and less impaired insulin sensitivity (23, 19, 27% normal) by homeostasis model assessment, lower triglyceride (1.8, 1.8, 1.3 mmol l-1), and higher
https://www.neuroscience.ox.ac.uk/publications/15322
UK Prospective Diabetes Study. XII: Differences between Asian, Afro-Caribbean and white Caucasian type 2 diabetic patients at...
Clinical and biochemical variables and prevalence of complications at diagnosis of diabetes were assessed in 5098 Type 2 diabetic patients in the UK Prospective Diabetes Study of whom 82% were white Caucasian, 10% Asian of Indian origin, and 8% Afro-Caribbean. The Asian patients were (p | 0.001) younger (mean age 52.3, 47.0, 51.0 years), less obese (BMI 29.3, 26.7, 27.9 kg m-2), had a greater waist-hip ratio, lower blood pressure (systolic 145, 139, 144, diastolic 87, 86, 89 mmHg) and prevalence of hypertension. They were more often sedentary (19, 39, 15%), more often abstained from alcohol (21, 55, 25%) and had a greater prevalence of first degree relatives with known diabetes (36, 44, 34%). The Afro-Caribbean patients had (p | 0.001) higher fasting plasma glucose (11.9, 11.3, 12.5 mmol l-1), more severely impaired beta-cell function (45, 35, 28% normal) and less impaired insulin sensitivity (23, 19, 27% normal) by homeostasis model assessment, lower triglyceride (1.8, 1.8, 1.3 mmol l-1), and higher
https://www.psych.ox.ac.uk/publications/15322
Tissue factor levels in type 2 diabetes mellitus
INTRODUCTION : Type 2 diabetes mellitus is a pandemic associated with disturbance inhaemostasis that could contribute to the development of diabetic vascular disease and accelerated atherosclerosis. In this population, hypercoagulation is prevalent, as well as pathological changes to erythrocytes. This is mainly due to upregulated circulating inflammatory markers. MATERIALS AND METHODS : Here we looked at tissue factor (TF) levels using ELISA, in a sample of diabetics, with and without cardiovascular complications. Diabetic subjects were recruited from the diabetic clinic at Steve Biko Academic Hospital, Pretoria, South Africa. 20 diabetics with cardiovascular disease and 22 without were enrolled to participate. RESULTS AND CONCLUSION : TF levels were significantly elevated in both diabetic groups when compared to the controls. We suggest that pathologic plasma TF activity, as marker of increased propensity of clot pathology, should be investigated. Agents that might lower TF levels might also ...
https://repository.up.ac.za/handle/2263/59525
UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance. - Radcliffe Department of MedicineUK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance. - Radcliffe Department of Medicine
The UK Prospective Diabetes Study (UKPDS) is a multi-centre, prospective, randomised, intervention trial of 5100 newly-diagnosed patients with Type 2 (non-insulin-dependent) diabetes mellitus which aims to determine whether improved blood glucose control will prevent complications and reduce the associated morbidity and mortality. Newly presenting Type 2 diabetic patients aged 25-65 years inclusive, median age 53 years, median body mass index 28 kg/m2 and median fasting plasma glucose 11.3 mmol/l, were recruited and treated initially by diet. Ninety five percent remained hyperglycaemic (fasting plasma glucose greater than 6 mmol/l) and were randomly allocated to different therapies. In the main randomisation, those who were asymptomatic and had fasting plasma glucose under 15 mmol/l were allocated either to diet policy, or to active policy with either insulin or sulphonylurea aiming to reduce the fasting plasma glucose to under 6 mmol/l. Over 3 years, the median fasting plasma glucose in those allocated
https://www.rdm.ox.ac.uk/publications/24002
U.K. Prospective Diabetes Study 16: Overview of 6 Years Therapy of Type II Diabetes: A Progressive Disease | DiabetesU.K. Prospective Diabetes Study 16: Overview of 6 Years Therapy of Type II Diabetes: A Progressive Disease | Diabetes
The objective of the U.K. Prospective Diabetes Study is to determine whether improved blood glucose control in type II diabetes will prevent the complications of diabetes and whether any specific therapy is advantageous or disadvantageous. The study will report in 1998, when the median duration from randomization will be 11 years. This report is on the efficacy of therapy over 6 years of follow-up and the overall incidence of diabetic complications. Subjects comprised 4,209 newly diagnosed type II diabetic patients who after 3 months diet were asymptomatic and had fasting plasma glucose (FPG) 6.0-15.0 mmol/l. The study consists of a randomized controlled trial with two main comparisons: 1) 3,867 patients with 1,138 allocated to conventional therapy, primarily with diet, and 2,729 allocated to intensive therapy with additional sulfonylurea or insulin, which increase insulin supply, aiming for FPG ,6 mmol/l; and 2) 753 obese patients with 411 allocated to conventional therapy and 342 allocated to ...
https://diabetes.diabetesjournals.org/content/44/11/1249?ijkey=82e8e038333c2e9ae89f09685b7bea1f865d6c07&keytype2=tf_ipsecsha
U.K. Prospective Diabetes Study 16: Overview of 6 Years Therapy of Type II Diabetes: A Progressive Disease | DiabetesU.K. Prospective Diabetes Study 16: Overview of 6 Years Therapy of Type II Diabetes: A Progressive Disease | Diabetes
The objective of the U.K. Prospective Diabetes Study is to determine whether improved blood glucose control in type II diabetes will prevent the complications of diabetes and whether any specific therapy is advantageous or disadvantageous. The study will report in 1998, when the median duration from randomization will be 11 years. This report is on the efficacy of therapy over 6 years of follow-up and the overall incidence of diabetic complications. Subjects comprised 4,209 newly diagnosed type II diabetic patients who after 3 months diet were asymptomatic and had fasting plasma glucose (FPG) 6.0-15.0 mmol/l. The study consists of a randomized controlled trial with two main comparisons: 1) 3,867 patients with 1,138 allocated to conventional therapy, primarily with diet, and 2,729 allocated to intensive therapy with additional sulfonylurea or insulin, which increase insulin supply, aiming for FPG ,6 mmol/l; and 2) 753 obese patients with 411 allocated to conventional therapy and 342 allocated to ...
https://diabetes.diabetesjournals.org/content/44/11/1249?ijkey=5985fa5c764831d9214cfb2aafe3dc0c93a85fbc&keytype2=tf_ipsecsha
Number and Function of Endothelial Progenitor Cells as a Marker of Severity for Diabetic Vasculopathy | Arteriosclerosis,...Number and Function of Endothelial Progenitor Cells as a Marker of Severity for Diabetic Vasculopathy | Arteriosclerosis,...
Diabetes mellitus is characterized by a widespread endothelial dysfunction20 and a 2- to 3-fold increased risk of developing cardiovascular diseases. As previously highlighted by our group, circulating blood cells in diabetes are subjected to many biochemical alterations attributable to the high oxidative stress and the unfavorable vascular environment.21,22. The present study demonstrates that number and function of circulating EPCs are profoundly altered in type 2 diabetic patients with PAD compared with diabetic patients without PAD. Moreover, we show strong correlations between circulating EPC levels and the severity of carotid and lower extremity arterial disease.. In this work we have used 2 independent methods to study endothelial progenitors: flow cytometry of fresh blood and ex vivo culture. Flow cytometry is considered the gold standard for quantitative enumeration of EPC, being sensitive, precise and reproducible23: using this technique, we have defined EPCs by the surface expression ...
http://atvb.ahajournals.org/content/26/9/2140
Macrovascular Complications Of Diabetes Mellitus Include QuizletMacrovascular Complications Of Diabetes Mellitus Include Quizlet
Persistent Problems of Diabetes Mellitus Flashcards. Kidneys might have a problem removing potassium in the event that renal deficiency is available.. MALE IMPOTENCE can be a common long lasting problem of diabetes. Macrovascular Complications Of Diabetes Mellitus Include Quizlet -- In the event that discovered early, and blood sugar brought in check, these types of
https://prediabetescenters.com/macrovascular-complications-of-diabetes-mellitus-include-quizlet-2/
Johns Hopkins students create high-heeled prosthetic - Washington TimesJohns Hopkins students create high-heeled prosthetic - Washington Times
Angela Manning lost her left leg to diabetic vascular disease. But it didnt stop her from wearing chunky, colorful, attention-grabbing high heels.
https://www.washingtontimes.com/news/2016/aug/13/johns-hopkins-students-create-high-heeled-prosthet/
Insulin Resistance in Type 1 Diabetes Mellitus and its Association with Patients Micro and Macrovascular Complications, Sex...Insulin Resistance in Type 1 Diabetes Mellitus and its Association with Patients Micro and Macrovascular Complications, Sex...
Insulin Resistance in Type 1 Diabetes Mellitus and its Association with Patients Micro and Macrovascular Complications, Sex Hormones and Other Clinical Data
https://adisjournals.figshare.com/articles/Insulin_Resistance_in_Type_1_Diabetes_Mellitus_and_its_Association_with_Patient_s_Micro_and_Macrovascular_Complications_Sex_Hormones_and_Other_Clinical_Data/10248191
UK Prospective Diabetes Study : Publications
Archives of Ophthalmology 2004;122:1631-1640. Published:Nov-2004. PMID:15534123. doi:10.1001/archopht.122.11.1631. A model to estimate the lifetime health outcomes of patients with type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS 68) ...
http://www.dtu.ox.ac.uk/generic/publications.php?Section=3&Year=2004
UK Prospective Diabetes Study : Publications
Medical Decision Making 2002;4:340-349. Published:Aug-2002. PMID:12150599. doi:10.1177/0272989X0202200412. Risk of Stroke in Type 2 Diabetes Estimated by the UK Prospective Diabetes Study Risk Engine ...
http://www.dtu.ox.ac.uk/generic/publications.php?Section=3&Year=2002
CML Psychiatry - Volume 23 Issue 3 - Interaction between Diabetes and Depression: Consequences for Cognition and the Brain
With over 280 million people suffering from diabetes mellitus, it is globally one of the most common non-communicable diseases [1,2]. The increasing prevalence of both types of diabetes [3,4], especially in low-income countries, poses a challenge to healthcare and to society at large. Diabetes is associated with microangiopathy, such as retinopathy, nephro-pathy, and peripheral (poly)neuropathy, as well as macroangiopathy. More recently, awareness has been increasing that diabetes also affects the brain [5]. Although this was recognized in the early 1920s [6], and further studied in post mortem research in the 1960s [7,8], in the past decade, with advances in neuroimaging techniques, this research field has been growing. Patients with diabetes show cognitive decrements in a wide range of functions, such as working memory, information processing speed, and executive functions, including mental flexibility and verbal fluency [9-11]. In addition, changes compared with control subjects have been ...
http://remedicajournals.com/CML-Psychiatry/BrowseIssues/Volume-23--Issue-3/Article-Interaction-between-Diabetes-and-Depression-Consequences-for
Immunoglobulin Heavy Chain Phenotypes in Diabetic Microangiopathy Evidence for an Immunogenetic Predisposition | Clinical...Immunoglobulin Heavy Chain Phenotypes in Diabetic Microangiopathy Evidence for an Immunogenetic Predisposition | Clinical...
Thank you for your interest in spreading the word about Clinical Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.clinsci.org/content/70/s13/56P.1
Tips From Other Journals - American Family PhysicianTips From Other Journals - American Family Physician
Type 2 diabetes mellitus is increasing in prevalence and is a common cause of morbidity and mortality. In persons with diabetes, vascular complications are the usual cause of adverse outcomes, and the latter often are divided into macrovascular (i.e., coronary artery disease, cerebrovascular disease, and peripheral vascular disease) and microvascular (i.e., retinopathy, nephropathy, and neuropathy). Tight glucose control reduces microvascular complications but does not affect macrovascular changes. Controlling cardiovascular risk factors in persons with diabetes can reduce macrovascular complications, and guidelines for the management of hypercholesterolemia in patients with type 2 diabetes have been formulated by the American College of Physicians (ACP).. Snow and colleagues in the Clinical Efficacy Assessment Subcommittee of the ACP developed guidelines for hyperlipidemia management in type 2 diabetes based on a systematic review of the evidence performed by Vijan and colleagues. Because there ...
http://www.aafp.org/afp/2005/0201/p588a.html
Diabetes mellitus - DocCheck FlexikonDiabetes mellitus - DocCheck Flexikon
Prognosis of Diabetes mellitus depends from an optimal metabolic control, as shown by large clinical studies like DCCC. Patients under continued hyperglycemic conditions are prone to high risk for developing complications like diabetic angiopathy, neuropathy, retinopathy or nephropathy. ON the other hand, hypoglycemia bears high acute threats. ...
https://flexikon.doccheck.com/en/Diabetes%20mellitus
Aging and Disease as Modifiers of Efficacy of Cell Therapy | Circulation ResearchAging and Disease as Modifiers of Efficacy of Cell Therapy | Circulation Research
Diabetes is one of the key risk factors for CAD, and its prevalence has increased over the last few years. The analysis of cultured EPCs and CD34+KDR+ cells and their functions in clinical studies identified type II diabetes as a major determinant of impairment. Patients with type I and type II diabetes exhibit lower number of CD34+KDR+ EPCs or cultured EPCs,14-16 and the reduced number of CD34+KDR+ cells was associated with the severity of diabetic vasculopathy.17. These results were consistent with animal experiments with obese diabetic mice (Lerdb), in which the function of progenitor and proangiogenic cells were impaired.18,19 Of note, diabetes was not only associated with a reduction of cell numbers but led to a profound impairment of cell functionality such as reduced migration toward cytokines, reduced proliferation, and reduced ability of the cells to integrate into vascular networks in vitro.9,15 The impaired migratory response resembled the previously shown diminished response of ...
http://circres.ahajournals.org/content/102/11/1319
PROGRESSION OF DIABETIC-RETINOPATHY IN TYPE-2 DIABETIC-PATIENTS IN THE UK PROSPECTIVE DIABETES STUDY - Radcliffe Department of...PROGRESSION OF DIABETIC-RETINOPATHY IN TYPE-2 DIABETIC-PATIENTS IN THE UK PROSPECTIVE DIABETES STUDY - Radcliffe Department of...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
https://www.rdm.ox.ac.uk/publications/764
Detection of Ischemia in Asymptomatic Diabetics - Full Text View - ClinicalTrials.govDetection of Ischemia in Asymptomatic Diabetics - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
https://clinicaltrials.gov/show/NCT00769275
10 Best & Comfortable Diabetic Shoes | Styles At Life10 Best & Comfortable Diabetic Shoes | Styles At Life
Diabetic shoes need a special stitch in its making, as the requirements of diabetic patients are unique. Here look at our 10 Best & Comfortable Diabetic Shoes.
http://stylesatlife.com/articles/diabetic-shoes/
SearchSearch
Macrovascular complications of type 2 diabetes mellitus (T2DM) include vascular calcification and arterial stiffness (AS). Measurement of arterial stiffness is currently of scientific interest due to its independent ...
https://repository.mu-varna.bg/handle/nls/435/discover?rpp=10&filtertype_0=dateIssued&filtertype_1=dateIssued&filter_relational_operator_1=equals&filter_relational_operator_0=equals&filter_1=%5B2010+TO+2020%5D&filter_0=2020&filtertype=subject&filter_relational_operator=equals&filter=vitamin+K2+supplementation
Stress Response To Surgery Under General Anesthesia In Type 2 Diabetic Patient | 22798Stress Response To Surgery Under General Anesthesia In Type 2 Diabetic Patient | 22798
Diabetic patients are considered to be at increased risk of preoperative morbidity and mortality because of the involvement of their vital organs and the auton...
https://www.omicsonline.org/proceedings/stress-response-to-surgery-under-general-anesthesia-in-type-2-diabetic-patient-22798.html
The myocardial perfusion scintigraphy in asymptomatic diabetic patientsThe myocardial perfusion scintigraphy in asymptomatic diabetic patients
Introduction: Asymptomatic diabetic patients are at increased risk of cardiovascular complications. Myocardial perfusion scan may be effective in risk evaluation in this population. Methods: 106 asymptomatic diabetic patients (age: min: 37, max: 82, mean: 57.73±8.88), including 56 females (52.8%) and 50 males (47.2%) were enrolled in the study. Myocardial perfusion scintigraphy was performed by Gated Single Photon Emission Computed Tomography (Gated-SPECT) method. Perfusion and function status was evaluated by qualitative and semi-quantitative parameters. Results: By visual analysis totally 40 out of 106 patients (37.7%) showed abnormal scan. From which, 26(24.5%) showed involvement in one, 13(12.3%) in two, and 1(0.9%) in all three vessel territories. By semi-quantitative method, from 103 patients, 28 (27.2%) were abnormal and 75 (72.8%) were normal. From all the asymptomatic diabetic patients, 11 patients (10.4%) had dilated left ventricles. Transient Ischemic Dilation (TID) was noted in 10
https://irjnm.tums.ac.ir/article_10763.html
Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy<...
TY - JOUR. T1 - Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy. AU - Cui, Xinglong. AU - Kushiyama, Akifumi. AU - Yoneda, Masayasu. AU - Nakatsu, Yusuke. AU - Guo, Ying. AU - Zhang, Jun. AU - Ono, Haruya. AU - Kanna, Machi. AU - Sakoda, Hideyuki. AU - Ono, Hiraku. AU - Kikuchi, Takako. AU - Fujishiro, Midori. AU - Shiomi, Masashi. AU - Kamata, Hideaki. AU - Kurihara, Hiroki. AU - Kikuchi, Masatoshi. AU - Kawazu, Shoji. AU - Nishimura, Fusanori. AU - Asano, Tomoichiro. PY - 2010/1/1. Y1 - 2010/1/1. N2 - The differentiation of macrophages into cytokine-secreting foam cells plays a critical role in the development of diabetic angiopathy. J774.1, a murine macrophage cell line, reportedly differentiates into foam cells when incubated with oxidized LDL, ApoE-rich VLDL or WHHLMI (myocardial infarction-prone Watanabe heritable hyperlipidemic) rabbit serum. In this study, serum samples from Type 2 diabetic patients were added to the medium with J774.1 cells ...
https://kyushu-u.pure.elsevier.com/en/publications/macrophage-foam-cell-formation-is-augmented-in-serum-from-patient
Coronary artery disease (CAD) extension-derived risk stratification for asymptomatic diabetic patients: usefulness of low-dose...Coronary artery disease (CAD) extension-derived risk stratification for asymptomatic diabetic patients: usefulness of low-dose...
Background: As one of the most frequent risk factors for cardiovascular disease, type 2 diabetes mellitus (T2DM) is one of the largest causes of death. However, an acute cardiac presentation is not uncommon in diabetic patients, and the current investigative approach remains often inadequate. The aim of our study was to retrospectively stratify the risk of asymptomatic T2DM patients using low-dose 640-slice coronary computed tomography angiography (CCTA). Materials and methods: CCTA examinations of 62 patients (mean age, 65 years) with previous diagnosis of type 2 diabetes and without cardiac symptoms were analyzed. Image acquisition was performed using a 640-slice CT. Per-patient, per-vessel and per-plaque analyses were performed. Stratification risk was evaluated according to the ESC guidelines. The patients were followed up after 2.21 ± 0.56 years from CCTA examination. Results: Coronary artery disease (CAD) was found in 58 patients (93.55%) presenting 290 plaques. Analysis of all samples ...
https://iris.univpm.it/handle/11566/283177
Diabetic Microvascular Disease: Endocrine Society StatementDiabetic Microvascular Disease: Endocrine Society Statement
This scientific statement provides an updated summary and review of the pathogenesis and effects of diabetic microvascular disease.
https://www.medscape.com/viewarticle/892224
Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5...Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5...
Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5 million Chinese adults.
https://scholars.duke.edu/display/pub1415460
Researchers find vitamin B1 deficiency key to vascular problems for diabeti...( lar and macrovascular complications. It...)
Health,lar and macrovascular complications. It likely reflects problems in en...The researchers found that the decreased plasma thiamine concentration...The researchers feel that important areas for future study are: confir......,Researchers,find,vitamin,B1,deficiency,key,to,vascular,problems,for,diabetic,patients,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
http://news.bio-medicine.org/medicine-news-3/Researchers-find-vitamin-B1-deficiency-key-to-vascular-problems-for-diabetic-patients-83-2/
1999 - Intensive therapy delayed microvascular complications in patients with type 2 diabetes mellitus and...1999 - Intensive therapy delayed microvascular complications in patients with type 2 diabetes mellitus and...
Metabolic abnormalities, including hyperglycemia, obesity, hypertension, and dyslipidemia, are frequently present inpatients with type 2 diabetes and are risk factors for both microvascular and macrovascular disease. The risk is further increased in patients with microalbuminuria. Clinical trial evidence has shown that reducing plasma glucose levels, blood pressure, or both slows the development or progression of microvascular complications. Individual trials have focused on 1 or, at most, 2 interventions. However, in routine clinical practice, multifactorial interventions are often needed to improve the many possible metabolic derangements. Gaede and colleagues study shows the benefits of intensively managing type 2 diabetes. A major strength of the study is its pragmatic design that compares multifactorial interventions (similar to those recommended by the American Diabetes Association) in a diabetes center with routine care by primary care providers. An impressive reduction in the ...
http://acpjc.org/Content/131/1/issue/ACPJC-1999-131-1-001.htm
Abstract 6011: Impact Of Atherosclerotic Disease Progression On Mid-term Clinical Outcome In Diabetic Patients In The Drug...Abstract 6011: Impact Of Atherosclerotic Disease Progression On Mid-term Clinical Outcome In Diabetic Patients In The Drug...
Drug-eluting stents (DES) implantation has been demonstrated to dramatically reduce restenosis and repeat revascularisation (RR) in diabetic patients. However, diabetic patients are prone to an accelerated atherosclerotic process and the impact of atherosclerotic disease progression (ADP) on RR and mid-term clinical outcome after DES implantation is not well known To determine whether RR in diabetic patients treated with prior DES is the result of either DES restenosis or native progression of atherosclerotic disease in the coronary vasculature, and to evaluate the impact of ADP on the mid-term clinical outcome. We followed 316 consecutive diabetic patients (227 men, age 69 ± 9 years) treated between June 2005 and September 2006 with at least one DES. Of these patients, 260 (82%) had a multivessel coronary disease, 148 (41%) had previous coronary revascularisation and 104 (32%) had insulin-dependent diabetes. During the follow-up (mean 590 ± 194 days) the cumulative incidence of major adverse ...
http://circ.ahajournals.org/content/118/Suppl_18/S_1046.2
NCT00498147 | Disease Management, Diabetes Complications, Diabetic Vascular Complications, Diabetic Neuropathy, Diabetic...NCT00498147 | Disease Management, Diabetes Complications, Diabetic Vascular Complications, Diabetic Neuropathy, Diabetic...
The DECIDE study will identify whether cardiovascular complication rates (the composite rate of myocardial infarction (MI), Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Grafting (CABG), stroke, carotid endarterectomy, peripheral revascularization, and peripheral amputation) are lower in patients who participate in managed diabetes care by ADEC in comparison to provincial and national rates. Comparison statistics will be provided by the Institute of Evaluative Sciences (ICES) Atlas 2003 and other Diabetes studies such as the 2005 DICE study. Complications such as nephropathy and retinopathy will be documented, along with hospitalization rates and all cause mortality. Clinical outcomes relevant to diabetes management such as blood pressure and lipids will also be compared ...
https://www.pfizer.com/science/find-a-trial/nct00498147
Microvascular complications of impaired glucose tolerance. Perspectives in diabetes | Singleton | Clinical DiabetologyMicrovascular complications of impaired glucose tolerance. Perspectives in diabetes | Singleton | Clinical Diabetology
Impaired glucose tolerance (IGT) serves as a marker for the state of insulin resistance and predicts both largeand small-vessel vascular complications, independent of a patients progression to diabetes. Patients with IGT are at significantly increased risk for death and morbidity due to myocardial infarction, stroke, and large-vessel occlusive disease. IGT is more predictive of cardiovascular morbidity than impaired fasting glucose, probably because it is a better surrogate for the state of insulin resistance. IGT is also independently associated with traditional microvascular complications of diabetes, including retinopathy, renal disease, and polyneuropathy, which are the topics of this review. Inhibition of nitric oxide- mediated vasodilation, endothelial injury due to increased release of free fatty acids and adipocytokines from adipocytes, and direct metabolic injury of endothelial and end-organ cells contribute to vascular complications. Early detection of IGT allows intensive diet and ...
https://journals.viamedica.pl/clinical_diabetology/article/view/8679
The Low Carb Diabetic: The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitusThe Low Carb Diabetic: The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus
In this retrospective study, we evaluated the medical records of 557 patients with type 2 diabetes admitted to the Endocrinology Outpatient Clinic from January to March 2010 and 112 healthy controls randomly selected from individuals admitted to the hospital for a check-up and who had a laboratory result for serum 25-OH vitamin D concentrations at screening. The levels of 25-OH vitamin D in patients with type 2 diabetes and the relationship between 25-OH vitamin D deficiency and microvascular complications were investigated. ...
http://thelowcarbdiabetic.blogspot.com/2015/07/the-relationship-between-microvascular.html
Dueling recommendations for the treatment of type 2 diabetes mellitus - J. JacobsDueling recommendations for the treatment of type 2 diabetes mellitus - J. Jacobs
Conversely, those patients with microvascular complications, e.g. retinopathy, neuropathy, and nephropathy, should be treated more aggressively. Microvascular complications seem to correlate more strongly with higher AIC. Macrovascular disease, e.g.cardiovascular events, meaning acute coronary syndromes, stroke, and peripheral arterial disease, seem to correlate less with aic reduction, though risk may be diminished not only with lifestyle changes, but also certain diabetes medications. Metformin, certain sodium-glucose co-transporter 2 inhibitors inhibitors, and glucagon-like peptide1 agonists have been shown to reduce cardiovascular events in some settings ...
https://jonathanjacobsmd.com/fish-oil-prevent-heart-disease/
Abstract 1395: Risk Predictors of First Microvascular Complications in Type 2 Diabetes Mellitus: The FIELD Study | CirculationAbstract 1395: Risk Predictors of First Microvascular Complications in Type 2 Diabetes Mellitus: The FIELD Study | Circulation
Statistical analyses used logistic regression stratified by treatment group and an exhaustive-search approach based on the likelihood score statistic.. Results: A total of 12 variables were significantly associated with any new first microvascular disease arising during the trial. Age, duration and control of diabetes (HbA1c), blood pressure, and prior cardiovascular disease (CVD) were strongly and independently associated with the development of microvascular disease. The on-study risk model for new disease over 5 years fitted relatively well, with a C-statistic of 0.652. No treatment-by-variable interactions were found. A simplified risk model developed for routine clinical practice maintained the predictive power.. Conclusions: Routinely measured clinical and biochemical variables can successfully identify most patients at high risk of developing microvascular disease. A simplified risk model may be usefully applied in clinical practice.. ...
http://circ.ahajournals.org/content/120/Suppl_18/S496.1
ClinMed International Library | A Case of Macrovascular Complications after Treatment with DPP-4 Inhibitor, Sitagliptin, in a...ClinMed International Library | A Case of Macrovascular Complications after Treatment with DPP-4 Inhibitor, Sitagliptin, in a...
Green recently investigated 14,671 patients with type 2 diabetes mellitus (T2DM) treated for 3 years with sitagliptin, a dipeptidyl peptidase (DPP)-4 inhibitor
https://clinmedjournals.org/articles/cmrcr/clinical-medical-reviews-and-case-reports-cmrcr-3-093.php?jid=cmrcr
2116 propranolol alcohol use
DIABETIC ANGIOPATHY Prolonged and, especially, should be practiced as often propranolol alcohol use possible under the direction of the ophthalmologist. Damasio. 16. These propranollo develop signs and symptoms within the first decade and generally survive into adulthood.
http://thesiri.ru/latest-drugs-in-india/propranolol-alcohol-use.html
Only DM duration independently tied to microvascular eventsOnly DM duration independently tied to microvascular events
(HealthDay)-In patients with type 2 diabetes, age or age at diabetes diagnosis and diabetes duration are independently associated with macrovascular events and death, but only duration of disease is independently associated ...
https://medicalxpress.com/news/2014-10-dm-duration-independently-tied-microvascular.html?deviceType=mobile
Abbildung 2: UKPDS - Complications - Blood Pressure
Rate of microvascular complications and myocardial infarction in the UKPDS according to the mean updated systolic blood pressure over the entire study duration (corrected for age, gender and ethnicity). Modified from [6 ...
http://www.kup.at/journals/abbildungen/gross/89.html
Quick Test Detects Inflammation in Diabetic PatientsQuick Test Detects Inflammation in Diabetic Patients
A new kit has been developed that will allow doctors to find out within minutes if diabetic patients are suffering from inflammation. Current procedures require patients to wait for several hours for the results obtained from the conventional full blood count test. Type 2 diabetes is the most common and is usually treated with lifestyle…
https://sriramsjpr.wordpress.com/2016/10/15/quick-test-detects-inflammation-in-diabetic-patients/
ClinMed International LibraryClinMed International Library
Discussion The results of this study indicate a rapid raise in the number of adults who meet the criteria for T2DMduring the first decade of the 21st century. These patients are currently receiving treatment at the primary care level. This rapid rise in such a short period of time is particularly disturbing because it suggests that large changes at the population level can occur in a relatively short period of time. If there is no coordinated response to arrest this increase in T2DM, the consequences are formidable. Increases in health expenditure, diabetic complications and cardiovascular morbidity and mortality are all likely to occur. These findings are particularly problematic given the strong association of T2DMand an array of both micro and macrovascular complication. Therefore, these findings have important implications for the debate on introducing stratergies such as health checks and other public health interventions to arrest the progression to overt diabetes.An effective and ...
https://clinmedjournals.org/articles/ijdcr/ijdcr-2-026.php?jid=ijdcr
At a glance factsheet: Diabetic retinopathyAt a glance factsheet: Diabetic retinopathy
At-risk groups, Clinical skills, Comorbidities, Diabetes & Primary Care, Diagnosis and screening, Microvascular complications, ...
https://cronfa.swan.ac.uk/Record/cronfa55643
Diabetic angiopathyDiabetic angiopathy
... is a form of angiopathy associated with diabetic complications. While not exclusive, the two most common ... Other forms of diabetic angiopathy include diabetic neuropathy and diabetic cardiomyopathy. Diabetes mellitus is the most ... "Diabetic dermopathy" is a manifestation of diabetic angiopathy. It is often found on the shin.There is also neuropathy; also ... Prognosis is generally poor for all forms of diabetic angiopathy, as symptomatology is tied to the advancement of the ...
https://en.wikipedia.org/wiki/Diabetic_angiopathy
AngiopathyAngiopathy
Diabetic angiopathy Cerebral amyloid angiopathy "angiopathy" at Dorland's Medical Dictionary (All articles with unsourced ... The best known and most prevalent angiopathy is diabetic angiopathy, a common complication of chronic diabetes. There are two ... diabetic kidney disease (Kimmelstiel-Wilson syndrome). It is also possible to classify angiopathy by the associated condition:[ ... Angiopathy is the generic term for a disease of the blood vessels (arteries, veins, and capillaries). ...
https://en.wikipedia.org/wiki/Angiopathy
James Bloodworth Jr.James Bloodworth Jr.
... experimental studies in dogs showed that meticulous control of glucose metabolism could effectively prevent diabetic angiopathy ... Bloodworth JM Jr: Diabetic retinopathy. Diabetes 1962; 11: 1-22. Engerman R, Bloodworth JM Jr, Nelson S: Relationship of ... Bloodworth JM Jr, Engerman RL, Anderson PJ: Microangiopathy in the experimentally-diabetic animal. Adv Metab Disord 1973; 2 ( ... In particular, his studies of diabetic retinopathy, in collaboration with ophthalmological colleagues at UWMS, defined the ...
https://en.wikipedia.org/wiki/James_Bloodworth_Jr.
Kidney diseaseKidney disease
Diabetic nephropathy is a progressive kidney disease caused by angiopathy of the capillaries in the glomeruli. It is ... which lead to diabetic nephropathy and hypertensive nephropathy, respectively. One cause of nephropathy is the long term usage ... "Dietary acid load and rapid progression to end-stage renal disease of diabetic nephropathy in Westernized South Asian people". ...
https://en.wikipedia.org/wiki/Kidney_disease
Diabetic footDiabetic foot
... diabetic angiopathy). Around half of the patients with a diabetic foot ulcer have co-existing PAD. Vitamin D deficiency has ... A critical evaluation of existing diabetic foot screening guidelines. The review of diabetic studies: RDS, 13(2-3), p.158. ... Wikimedia Commons has media related to diabetic foot. MedlinePlus: Diabetic Foot (CS1 maint: multiple names: authors list, CS1 ... Presence of several characteristic diabetic foot pathologies such as infection, diabetic foot ulcer and neuropathic ...
https://en.wikipedia.org/wiki/Diabetic_foot
List of MeSH codes (C19)List of MeSH codes (C19)
... diabetic angiopathies MeSH C19.246.099.500.191 - diabetic foot MeSH C19.246.099.500.382 - diabetic retinopathy MeSH C19.246. ... diabetic nephropathies MeSH C19.246.099.937 - diabetic neuropathies MeSH C19.246.099.937.250 - diabetic foot MeSH C19.246. ... 099.750 - diabetic coma MeSH C19.246.099.750.490 - hyperglycemic hyperosmolar nonketotic coma MeSH C19.246.099.812 - diabetic ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C19)
TolperisoneTolperisone
... and lumbar syndromes Arthrosis of the large joints Obliterating atherosclerosis of the extremity vessels Diabetic angiopathy ...
https://en.wikipedia.org/wiki/Tolperisone
List of diseases (D)List of diseases (D)
... insulin dependent Diabetic angiopathy Diabetic embryopathy Diabetic nephropathy Diabetic neuropathy Diamond-Blackfan anemia ...
https://en.wikipedia.org/wiki/List_of_diseases_(D)
Glossary of diabetesGlossary of diabetes
Diabetic angiopathy See: Angiopathy. Diabetic coma see coma Diabetic ketoacidosis (DKA) see acidosis Diabetic myelopathy Spinal ... Diabetic nephropathy See: Nephropathy Diabetic neuropathy See: Neuropathy Diabetic osteopathy Bone disease secondary to chronic ... For a diabetic, coma can be caused by hypoglycemia or by diabetic ketoacidosis. Comatose in a coma; not conscious. ... Women who become diabetic during their pregnancies have a 15% higher chance of developing preeclampsia; women who are diabetic ...
https://en.wikipedia.org/wiki/Glossary_of_diabetes
Epigenetics of diabetes Type 2Epigenetics of diabetes Type 2
Also miR-192 levels have been shown to be increased in glomeruli isolated from diabetic mice when compared to non-diabetic mice ... Nephropathy is another common symptom of diabetes patients and is caused by angiopathy of the capillaries in the kidneys. A ... Metabolic memory is the phenomenon of diabetic vascular stresses persisting after glucose normalization in diabetic patients ... Being in this state of diabetic stress leads to long term metabolic memory and altered epigenome with adverse side effects on ...
https://en.wikipedia.org/wiki/Epigenetics_of_diabetes_Type_2
Complications of diabetesComplications of diabetes
... that non-diabetic first-degree relatives of diabetics had elevated enzyme levels associated with diabetic renal disease and ... Chronic elevation of blood glucose level leads to damage of blood vessels called angiopathy. The endothelial cells lining the ... It is why it takes longer for diabetics to heal from leg and foot wounds and why diabetics are prone to leg and foot infections ... Diabetic amyotrophy is muscle weakness due to neuropathy. Diabetic retinopathy, growth of friable and poor-quality new blood ...
https://en.wikipedia.org/wiki/Complications_of_diabetes
List of MeSH codes (C18)List of MeSH codes (C18)
... cerebral amyloid angiopathy, familial MeSH C18.452.090.100 - cerebral amyloid angiopathy MeSH C18.452.090.100.160 - cerebral ... diabetic ketoacidosis MeSH C18.452.076.176.652 - ketosis MeSH C18.452.076.354 - alkalosis MeSH C18.452.076.354.271 - alkalosis ... diabetic ketoacidosis MeSH C18.452.394.750.774 - prediabetic state MeSH C18.452.394.937 - glycosuria MeSH C18.452.394.937.450 ... cerebral amyloid angiopathy, familial MeSH C18.452.648.151 - brain diseases, metabolic, inborn MeSH C18.452.648.151.050 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C18)
MicroangiopathyMicroangiopathy
The efficacy of calcium dobesilate has been described e.g. in patients with diabetic retinopathy or diabetic nephropathy. " ... It can be contrasted to coronary heart disease, an angiopathy that affects the larger vessels. Cerebral small vessel disease ... diabetic retinopathy) or kidney (diabetic nephropathy). Nerves and neurons, if not sufficiently supplied with blood, are also ... Laser therapy of diabetic retinopathy.[citation needed] A number of medicines, such as calcium dobesilate, are being marketed ...
https://en.wikipedia.org/wiki/Microangiopathy
Type IV collagenType IV collagen
Increased glomerular and mesangial deposition of collagen IV occurs in diabetic nephropathy and increased urinary levels are ... Mutations in COL4A1 exons 24 and 25 are associated with HANAC (autosomal dominant hereditary angiopathy with nephropathy, ... "COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps". The New England Journal of Medicine. ...
https://en.wikipedia.org/wiki/Type_IV_collagen
AOC3AOC3
In diabetic patients, the amine oxidase activity stimulates glucose uptake via translocation of transporters to the cell ... aggregation along with oxidative stress and thus are considered a potential risk factor for stress-related angiopathy. In these ... This mimics insulin and interferes with cell processes in diabetic patients. Additionally, hydrogen peroxide, along with ... diabetic patients have a greater chance of developing oncogenesis and tumor progression. In one study, serum VAP-1 was shown to ...
https://en.wikipedia.org/wiki/AOC3
List of MeSH codes (C14)List of MeSH codes (C14)
... diabetic foot MeSH C14.907.320.382 - diabetic retinopathy MeSH C14.907.355.350 - embolism MeSH C14.907.355.350.254 - embolism, ... cerebral amyloid angiopathy MeSH C14.907.253.560.200.200.160 - cerebral amyloid angiopathy, familial MeSH C14.907.253.560. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C14)
International Classification of Headache DisordersInternational Classification of Headache Disorders
... irritation or distortion of cranial nerves or upper cervical roots by structural lesions Optic neuritis Ocular diabetic ... Headache attributed to benign angiopathy of the central nervous system Headache attributed to pituitary apoplexy Headache ...
https://en.wikipedia.org/wiki/International_Classification_of_Headache_Disorders
Cystatin CCystatin C
Levy E, Jaskolski M, Grubb A (January 2006). "The role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology ... including diabetic patients, in chronic kidney disease (CKD), and after kidney transplant. It has been suggested that cystatin ... "Entrez Gene: CST3 cystatin C (amyloid angiopathy and cerebral hemorrhage)". Hwang SJ, Yang Q, Meigs JB, Pearce EN, Fox CS ( ... Mutations in the cystatin 3 gene are responsible for the Icelandic type of hereditary cerebral amyloid angiopathy, a condition ...
https://en.wikipedia.org/wiki/Cystatin_C
List of MeSH codes (C10)List of MeSH codes (C10)
... cerebral amyloid angiopathy MeSH C10.228.140.300.510.200.200.160 - cerebral amyloid angiopathy, familial MeSH C10.228.140.300. ... diabetic neuropathies MeSH C10.668.829.350 - guillain-barre syndrome MeSH C10.668.829.350.500 - miller fisher syndrome MeSH ... cerebral amyloid angiopathy, familial MeSH C10.228.140.163.100.175 - citrullinemia MeSH C10.228.140.163.100.320 - galactosemias ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C10)
Plasma gelsolinPlasma gelsolin
"Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin ... "Reducing Available Soluble A-Amyloid Prevents Progression of Cerebral Amyloid Angiopathy in Transgenic Mice". J Neuropathol Exp ...
https://en.wikipedia.org/wiki/Plasma_gelsolin
ARC1915-12-25-CIHI Self Learning OnlineCoding for Diabetes - Diabetic Angiopathy (CLSS)May 29, 2011 - CHIMAARC1915-12-25-CIHI Self Learning OnlineCoding for Diabetes - Diabetic Angiopathy (CLSS)May 29, 2011 - CHIMA
ARC1915-12-25-CIHI Self Learning OnlineCoding for Diabetes - Diabetic Angiopathy (CLSS)May 29, 2011. Former Category ... ARC1915-12-25-CIHI Self Learning OnlineCoding for Diabetes - Diabetic Angiopathy (CLSS)May 29, 2011. ...
https://www.echima.ca/credits/arc1915-12-25-cihi-self-learning-onlinecoding-for-diabetes-diabetic-angiopathy-clssmay-29-2011/
Natural cure for Diabetic angiopathy and alternative treatments
Get natural cures for Diabetic angiopathy that can make a difference in your life or the life of someone you love with ... Diabetic angiopathy by state. Diabetic angiopathy in Alabama. Diabetic angiopathy in Alaska. Diabetic angiopathy in Arizona. ... Diabetic angiopathy in Iowa. Diabetic angiopathy in Kansas. Diabetic angiopathy in Kentucky. Diabetic angiopathy in Louisiana. ... Diabetic angiopathy in North Carolina. Diabetic angiopathy in North Dakota. Diabetic angiopathy in Ohio. Diabetic angiopathy in ...
http://www.naturalcurefor.com/treatments/diabetic-angiopathy
Life-course socio-economic position, area deprivation and Type 2 diabetes: findings from the British Womens Heart and Health...Life-course socio-economic position, area deprivation and Type 2 diabetes: findings from the British Women's Heart and Health...
Diabetic Angiopathies / epidemiology* * Female * Humans * Insulin Resistance / ethnology * Insulin Resistance / physiology * ...
https://pubmed.ncbi.nlm.nih.gov/19046246/
Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Foot Ulcers. - Full Text View -...Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Foot Ulcers. - Full Text View -...
Diabetic Foot. Foot Ulcer. Ulcer. Pathologic Processes. Diabetic Angiopathies. Vascular Diseases. Cardiovascular Diseases. Leg ... Subject is diagnosed with Type I or Type II diabetics and has diabetic foot ulcers for longer than 4 weeks at the screening ... Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Foot Ulcers.. The safety and ... Non-diabetic pathophysiologic ulcer.. *The ulcer has increased or decreased in size by 30% or more during one week after the ...
https://clinicaltrials.gov/ct2/show/NCT03370874
Simulated physician learning intervention to improve safety and quality of diabetes care: a randomized trial
Diabetic Angiopathies/therapy * Glycated Hemoglobin A/metabolism * Hypoglycemic Agents/therapeutic use * Metformin/therapeutic ...
https://www.healthpartners.com/knowledgeexchange/display/document-rn19195
中文中文
Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)
Categories: Diabetic Angiopathies Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Diabetic+Angiopathies&parentid=26884&catid=8211
Get a Physicians Perspective on Documentation ImprovementGet a Physician's Perspective on Documentation Improvement
ABI/Flochec (screen for diabetic peripheral angiopathies). *NCV/monofilament screening for diabetic peripheral neuropathy ... E11.21 Type 2 diabetes mellitus with diabetic nephropathy. E11.22 Type 2 diabetes mellitus with diabetic chronic kidney disease ... for diabetic cataract or with "other diabetic ophthalmic complication" - use an additional code to identify complication) or ... E11.29 Type 2 DM with other diabetic kidney complication e.g., Type 2 DM with renal tubular degeneration. Support Your ...
https://www.aapc.com/blog/36231-get-a-physicians-perspective-on-documentation-improvement/
Prophylactic gene therapy with human tissue kallikrein ameliorates limb ischemia recovery in type 1 diabetic mice<...Prophylactic gene therapy with human tissue kallikrein ameliorates limb ischemia recovery in type 1 diabetic mice<...
keywords = "Animals, Arterioles, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Extremities ... Ultimately, correction of diabetic endotheliopathy by Ad.hTK allowed proper perfusion recovery as seen in nondiabetic mice. ... Ultimately, correction of diabetic endotheliopathy by Ad.hTK allowed proper perfusion recovery as seen in nondiabetic mice. ... Ultimately, correction of diabetic endotheliopathy by Ad.hTK allowed proper perfusion recovery as seen in nondiabetic mice. ...
https://research-information.bris.ac.uk/en/publications/prophylactic-gene-therapy-with-human-tissue-kallikrein-ameliorate
T Yasuis Research | CureHunterT Yasui's Research | CureHunter
Diabetic Neuropathies (Diabetic Neuropathy) 10/2001. 1. Diabetic Angiopathies (Diabetic Angiopathy) 10/2001. ...
https://www.curehunter.com/public/authorSummary-Yasui,%20T.do
Circulating soluble receptor for advanced glycation end products is inversely associated with body mass index and waist/hip...
Diabetic Angiopathies Medicine & Life Sciences 20% * Healthy Volunteers Medicine & Life Sciences 20% ... has been documented in patients with diabetes but no information is available in non-diabetic subjects. The aim of this study ... has been documented in patients with diabetes but no information is available in non-diabetic subjects. The aim of this study ... has been documented in patients with diabetes but no information is available in non-diabetic subjects. The aim of this study ...
https://moh-it.pure.elsevier.com/en/publications/circulating-soluble-receptor-for-advanced-glycation-end-products-
HuGE Navigator|HuGE Literature Finder|PHGKBHuGE Navigator|HuGE Literature Finder|PHGKB
No article was found for Diabetic Angiopathies and ATM[original query]. File Formats Help:. How do I view different file ...
https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Diabetic%20Angiopathies+and+ATM&Mysubmit=search
Search Results (9) | Profiles RNS
Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes MellitusAssociation of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus
... in type 1 diabetes mellitus and an interrelationship between them may play an important role in pathogenesis of diabetic ... and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. Patients were divided into two groups ... "Von willebrand factor in diabetic angiopathy," Diabetes and Metabolism, vol. 24, no. 4, pp. 327-336, 1998. ... "Study of the role of interleukin-6 and highly sensitive C-reactive protein in diabetic nephropathy in type 1 diabetic patients ...
https://www.hindawi.com/journals/jdr/2016/2315260/
Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes. - Clinical Trial Service...
Among the diabetic rats mean plasma glucose concentrations for the groups ranged from 27-4 mmol/l (494 mg/100 ml) in the ... Diabetic rats were randomly allocated to different groups, either receiving no treatment or treated with a low carbohydrate ... Animals, Basement Membrane, Blood Glucose, Body Weight, Capillaries, Diabetes Mellitus, Experimental, Diabetic Angiopathies, ... Among the diabetic rats mean plasma glucose concentrations for the groups ranged from 27-4 mmol/l (494 mg/100 ml) in the ...
https://www.ctsu.ox.ac.uk/publications/88422
Fibrogenesis & Tissue Repair | ArticlesFibrogenesis & Tissue Repair | Articles
Diabetic angiopathy and angiogenic defects Diabetes is one of the most serious health problems in the world. A major ... complication of diabetes is blood vessel disease, termed angiopathy, which is characterized by abnormal angiogenesis. In this ...
https://fibrogenesis.biomedcentral.com/articles?searchType=journalSearch&sort=PubDate&page=2
Development of Glycogen synthase kinase-3 (GSK-3) inhibitors by GlaxoSmithKline and by Johnson & Johnson (Target of the Month,...Development of Glycogen synthase kinase-3 (GSK-3) inhibitors by GlaxoSmithKline and by Johnson & Johnson (Target of the Month,...
... and is associated with diabetic complications, particularly retinopathy, angiopathy, nephropathy, macular edema, neuropathy, ... while the PKC inhibiting activity could limit diabetic complications. ...
https://www.pharmiweb.com/article/development-of-glycogen-synthase-kinase-3-gsk-3-inhibitors-by-glaxosmithkline-and-by-johnson-joh
HuGE Navigator|Genopedia|PHGKBHuGE Navigator|Genopedia|PHGKB
HuGE Navigator|Genopedia|PHGKBHuGE Navigator|Genopedia|PHGKB
Diabetic Angiopathies 1 0 Thrombotic Microangiopathies 1 0 Hypertension 1 0 Postoperative Complications 1 0 ...
https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=ADAMTS13&geneID=11093&typeSubmit=GO&check=y&typeOption=gene&which=2&pubOrderType=pubD
HuGE Navigator|Genopedia|PHGKBHuGE Navigator|Genopedia|PHGKB
Diabetic Angiopathies 1 0 Edema 1 0 Asymptomatic Diseases 1 0 Note: The number of publications displayed in this table will ...
https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=HPR&geneID=3250&typeSubmit=GO&check=y&typeOption=gene&which=2&pubOrderType=pubD
DeCSDeCS
Diabetic Angiopathies Entry term(s). Angiopathies, Diabetic Angiopathy, Diabetic Diabetic Angiopathy Diabetic Vascular ... Angiopathies diabétiques Entry term(s):. Angiopathies, Diabetic. Angiopathy, Diabetic. Diabetic Angiopathy. Diabetic ... Diabetic Microangiopathy. Diabetic Vascular Complication. Diabetic Vascular Complications. Diabetic Vascular Disease. Diabetic ... Vascular Complications, Diabetic Vascular Disease, Diabetic Vascular Diseases, Diabetic Microangiopathy, Diabetic - Narrower ...
https://decs.bvsalud.org/en/ths/resource/?id=3948
IMSEAR at SEARO: Editorial: Pathogenesis of diabetes mellitus.
Diabetic Angiopathies. en_US. dc.subject.mesh. Female. en_US. dc.subject.mesh. Humans. en_US. ...
https://imsear.searo.who.int/handle/123456789/98330?mode=full
How Do I Get Rid Of High Blood Sugar? - LienminhhtxhaiphongHow Do I Get Rid Of High Blood Sugar? - Lienminhhtxhaiphong
Type 2 diabetes mellitus with diabetic peripheral angiopathy without gangrene? the second day, it how do i get rid of high ... What diabetic meds can thin blood? *dry mouth and blood sugar:In fact, it all makes sense, and most of them refer to these ... Is sucralose ok for diabetics? not burdened by the change of dynasties.Then the mana is infinite, and it can be listed as true ... At this moment, the fox demon seemed to have Diabetic Type 2 Medications how do i get rid of high blood sugar a sudden cardiac ...
https://lienminhhtxhaiphong.org.vn/bloodsugarblog/how-xad-do-i-get-rid-of-high-blood-sugar/
What is a Diabetic Boot & How Does It Help Treat Diabetic Ulcers?What is a Diabetic Boot & How Does It Help Treat Diabetic Ulcers?
Diabetic boots are known to slow down the growth of a diabetic ulcer and can also help prevent the spread of infection from an ... A 2011 study proved that by wearing a diabetic boot, diabetic ulcers on the foot that were not accompanied by an infection, ... An ulcer that is accompanied by an infection, however, lengthens this recover time even after wearing diabetic boots. ... A diabetic boot is used by people having diabetes to relieve the pressure on their foot while walking. ...
https://www.epainassist.com/diabetes/what-is-a-diabetic-boot-and-how-does-it-help-treat-diabetic-ulcers
Of vascular diseaseOf vascular disease
Diabetic angiopathy of the lower extremities: treatment and symptoms. Diabetic angiopathy is a dangerous consequence of the ... Microangiopathy: a brain (cerebral) and the diabetic form of the disease. Microangiopathy is a disease associated with damage ...
http://vascular.vsebolezni.com/bolezni/
Elevation of Plasma Thrombomodulin Level in Diabetic Patients With Early Diabetic Nephropathy | Diabetes | American Diabetes...Elevation of Plasma Thrombomodulin Level in Diabetic Patients With Early Diabetic Nephropathy | Diabetes | American Diabetes...
... it is supposed that an injury in the vascular endothelial cell may progress with the advance of diabetic angiopathy, and TM ... Elevation of Plasma Thrombomodulin Level in Diabetic Patients With Early Diabetic Nephropathy Yasunori Iwashima; Yasunori ... Elevation of Plasma Thrombomodulin Level in Diabetic Patients With Early Diabetic Nephropathy. Diabetes 1 August 1990; 39 (8): ... In this study, fasting plasma TM concentrations in 67 diabetic patients with different degrees of albuminuria (39 men aged 57 ...
https://diabetesjournals.org/diabetes/article-split/39/8/983/7591/Elevation-of-Plasma-Thrombomodulin-Level-in
Code System Concept
Diabetic peripheral vascular disease Active Synonym false false 302011 Diabetic peripheral angiopathy Active Synonym false ... Peripheral angiopathy due to diabetes mellitus (disorder). Code System Preferred Concept Name. Peripheral angiopathy due to ... Peripheral angiopathy due to diabetes mellitus Active Synonym false false 473994010 Diabetes with peripheral circulatory ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=127014009
Journal of Cardiology | Cardiology and Research JournalJournal of Cardiology | Cardiology and Research Journal
Diabetic Angiopathies. *Embolism and Thrombosis. *Molecular and Genetics of Cardiovascular Disease. *Vascular System Injuries ...
https://www.ospublishers.com/Journal-of-Cardiology-JOC.html
RetinopathyComplicationsDiabetesNephropathyPeripheralMicroangiopathyNeuropathyMicrovascularUlcersInsulinKetoacidosisEndothelialDiseaseHypertensionStreptozotocinArterialRandomly allocatedTreatmentsPatientsTherapyTreatmentCardiovascularBlood vesselsMiceAntibioticsCONCLUSIONFootTypesDevelopmentFound
Retinopathy8
  • E08.3543 is a valid billable ICD-10 diagnosis code for Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment, bilateral . (icd10coded.com)
  • diabetic retinopathy treatment injection nycross the single, Diabetes Medicines Invokana as well as another study that is a complete risk factor negative effects of it medication, such as populations, and their healthcare team. (erakey.com)
  • safety with ed medication and diabetic retinopathy, so it is important to evaluate this condition. (promonticelli.it)
  • best diabetic how much can you lower A1C in 3 months retinopathy treatment in india, and the recent reported to the test. (promonticelli.it)
  • treatment guidlines for diabetic retinopathy using insulin, and insulin injection is a significant difference in a significant reduction in the risk of type 2 diabetes. (condopromo.com)
  • The study outcome was the time to first hospitalization for mainly microvascular diabetic complications - hyperosmolarity, ketoacidosis, nephropathy, retinopathy, neuropathy, angiopathy, or arthropathy - starting at 12 months. (medscape.com)
  • Long-term complications from high blood sugar can include heart disease , strokes , diabetic retinopathy where eyesight is affected, kidney failure which may require dialysis , and poor circulation of limbs leading to amputations . (thediabeticpharmacist.com)
  • However, as a chronic state of mild hyperglycemia often persists, long-term complications, such as retinopathy, nephropathy, neuropathy and micro-angiopathy, cannot be fully prevented by this treatment regimen, emphasizing the need for novel therapies that can revert or at least halt disease progression. (medscape.com)
Complications12
  • Similar to most complications brought about by diabetes, diabetic angiopathy is primarily due to hyperglycemia or the high levels of blood sugar known to us as glucose. (naturalcurefor.com)
  • These discoveries disclose new therapeutic options for the treatment of diabetic complications. (bris.ac.uk)
  • In healthy subjects plasma levels of sRAGE were negatively correlated with BMI and waist/hip ratio supporting a possible protective role for these proteins before any evidence of diabetic or vascular complications. (elsevier.com)
  • The complications of diabetic nephropathy, such as end stage renal disease and cardiovascular events, are responsible for an increased morbidity and mortality among diabetic patients [ 3 ]. (hindawi.com)
  • An imbalance between VWF and ADAMTS13 may also contribute to the development of microvascular complications in diabetic patients [ 13 ]. (hindawi.com)
  • Thus the GSK-3 inhibiting component of this molecule could improve glucose handling, while the PKC inhibiting activity could limit diabetic complications. (pharmiweb.com)
  • Diabetic foot ulcers are one of the most common complications in people having diabetes. (epainassist.com)
  • Data from several studies over the last two decades have demonstrated that MAU is not only a predictor of diabetic complications but also a powerful independent risk factor for coronary artery disease (CAD), moreover, MAU predicts development of ischemic cardiovascular events related to the development of atherosclerosis [ 5 ]. (biomedcentral.com)
  • Recently, it has diabetics herbal medicines India been shown to reduce the risk how much cinnamon to reduce blood sugar of cardiovascular complications and mortality, and wellness and stroke. (neufont.com)
  • Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5 million Chinese adults. (ox.ac.uk)
  • CONCLUSION: In this large epidemiological study in Chinese adults, higher fresh fruit consumption was associated with significantly lower risk of diabetes and, among diabetic individuals, lower risks of death and development of major vascular complications. (ox.ac.uk)
  • hémoglobine glyquée était corrélée significativement aux complications dégénératives micro angiopathies (p=0,0058) et macro angiopathies (p=0,00017) chez les diabétiques. (bvsalud.org)
Diabetes21
  • When angiopathy is caused by diabetes, it is called diabetic angiopathy. (naturalcurefor.com)
  • A role for the soluble form of RAGE (sRAGE), which acts as a decoy for AGE, has been documented in patients with diabetes but no information is available in non-diabetic subjects. (elsevier.com)
  • Inflammatory and hypercoagulability status are associated with nephropathy in type 1 diabetes mellitus and an interrelationship between them may play an important role in pathogenesis of diabetic nephropathy. (hindawi.com)
  • If you have diabetes what is blood sugar when in diabetic shock? (org.vn)
  • In fact, people suffering from diabetes have a ten times higher risk of requiring an amputation as compared to those who are non-diabetics. (epainassist.com)
  • A diabetic boot is used by people having diabetes to relieve the pressure on their foot while walking. (epainassist.com)
  • Se buscará describir los dos tipos de tratamientos más usados en jóvenes y adultos para la diabetes tipo 2 en el presente. (ticketwomanstyle.shop)
  • E10.42 Type 1 diabetes mellitus with diabetic polyne. (ticketwomanstyle.shop)
  • E10.43 Type 1 diabetes mellitus with diabetic autono. (ticketwomanstyle.shop)
  • E10.44 Type 1 diabetes mellitus with diabetic amyotr. (ticketwomanstyle.shop)
  • E10.51 Type 1 diabetes mellitus with diabetic periph. (ticketwomanstyle.shop)
  • Oct 01, 2022 · E09.21 Drug or chemical induced diabetes mellitus with diabetic nephropathy E09.22 Drug or chemical induced diabetes mellitus with diabetic chronic kidney disease Reimbursement claims with a date of service on or after October 1 , 2015 require the use of ICD-10 -CM codes. (ticketwomanstyle.shop)
  • treatment of hypoglycemia in diabetic patients with T2DM.8% of patients aged 411 patients with it who look at 5 years during the day of age 46 percent of the previously diagnosis of type 2 diabetes. (erakey.com)
  • We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. (ox.ac.uk)
  • treatment for diabetic ulcers on feet and in the International Diabetes how much can you lower A1C in 3 months Committee, then, the Heart Annnti-care team will be another study. (promonticelli.it)
  • They can diabetes medications UK also be constantly known as non-diabetic patients and treatments and monitoring without type 2 diabetes. (promonticelli.it)
  • water pills for diabetics, using the Outcommunity of the early on the steps of Type 1 diabetes, and it is important to avoid it. (promonticelli.it)
  • ET-1 levels are increased in diabetes, and observations suggest the involvement of ETs in the pathogenesis of diabetic angiopathy. (shengsci.com)
  • diabetic medication metformin, or 90.7% of people with type 2 diabetes will be able told it, if they are diagnosed with type 2 diabetes. (condopromo.com)
  • Type 1 diabetes is, by contrast to the epidemic prevalence of Type 2 diabetes, a rare disease, with less than 10% of all diabetics suffering from Type 1. (medscape.com)
  • In particular, the nonobese diabetic (NOD) mouse model represents an important source of information, not only providing crucial information on Type 1 diabetes pathogenesis, but also unveiling important insights on the mechanisms of immunoregulation and tolerance. (medscape.com)
Nephropathy3
  • Emerging evidence suggests that inflammatory pathways play an important role in the development and progression of diabetic nephropathy. (hindawi.com)
  • Elevated levels of VWF can promote microthrombi formation in vasculature, leading to hypercoagulability status and formation of D-Dimer, which is a fragment of fibrin degradation and has also been associated with diabetic nephropathy [ 11 , 12 ]. (hindawi.com)
  • In a previous study, we have described the association between VWF, ADAMTS13, and D-Dimer with different levels of renal dysfunction in DM1 patients and we have raised the hypothesis that inflammation could be associated with hypercoagulability in patients with diabetic nephropathy [ 14 ]. (hindawi.com)
Peripheral2
  • Later Prevention, including analysis recorded by the an algorithm of the best lifestyle intervention diabetic peripheral angiopathy treatment and other methods, the end of the US costs are the first first three other costs for each study. (erakey.com)
  • diabetic peripheral angiopathy treatment, published by a national VID-10-50% of the American Association. (neufont.com)
Microangiopathy1
  • For example, diabetics may develop microangiopathy with thickening of capillaries in many areas, including the eye . (rxlist.com)
Neuropathy1
  • diabetic neuropathy treatment vitamin b120, which is not yet been not enough to be due to any excess weight, which is a chronic condition. (neufont.com)
Microvascular1
  • Morphological and structural analysis showed that STZ-induced diabetic mice had significantly reduced microvascular density in lamina propria (33% of the nondiabetic control values), and severely decreased nerve contents in the detrusor region (42% of the nondiabetic control values). (bvsalud.org)
Ulcers8
  • Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Foot Ulcers. (clinicaltrials.gov)
  • Subject is diagnosed with Type I or Type II diabetics and has diabetic foot ulcers for longer than 4 weeks at the screening visit. (clinicaltrials.gov)
  • What is a Diabetic Boot & How Does It Help Treat Diabetic Ulcers? (epainassist.com)
  • A diabetic boot helps treat people with diabetic foot ulcers. (epainassist.com)
  • What exactly is diabetic foot ulcers and how does a diabetic boot help in preventing a serious infection is what we look at today. (epainassist.com)
  • A 2011 study proved that by wearing a diabetic boot, diabetic ulcers on the foot that were not accompanied by an infection, heal within six to eight weeks. (epainassist.com)
  • While most studies have shown a diabetic boot to be very helpful in promoting healing of diabetic foot ulcers, there was a study conducted in 2016 that found no difference in the healing of diabetic foot ulcers by wearing a removable diabetic boot, an irremovable diabetic boot, and a normal cast. (epainassist.com)
  • In spite of these results, most doctors still prefer to prescribe a diabetic boot to patients suffering from diabetic foot ulcers in order to speed up the recovery process. (epainassist.com)
Insulin3
  • Diabetic rats were randomly allocated to different groups, either receiving no treatment or treated with a low carbohydrate diet or insulin, or both. (ox.ac.uk)
  • Among the diabetic rats mean plasma glucose concentrations for the groups ranged from 27-4 mmol/l (494 mg/100 ml) in the untreated rats to 9-8 mmol/l (177 mg/100 ml) in those receiving both a low carbohydrate diet and insulin. (ox.ac.uk)
  • what medications do type how much can you lower A1C in 3 months 1 diabetics take to process insulin, but it's essential to prevent. (promonticelli.it)
Ketoacidosis1
  • All index visits of adult (≥18 years) ED patients with a final diagnosis of hyperglycemia, diabetic ketoacidosis , or hyperosmolar hyperglycemic state and its related codes under the International Statistical Classification of Diseases and Related Health Problems, 10th Revision ( ICD-10 ), according to the treating physician were eligible to be. (ticketwomanstyle.shop)
Endothelial6
  • We found that limb perfusion recovery of saline-injected type 1 diabetic mice is delayed because of insufficient reparative neovascularization and excessive activation of endothelial cell apoptosis. (bris.ac.uk)
  • It is a surrogate marker for endothelial dysfunction and is independently associated with atherosclerotis in diabetic and in non-diabetic patients. (biomedcentral.com)
  • In the present study, we report that Ago2 administration can effectively improve penile erection by enhancing cavernous endothelial cell angiogenesis and survival under diabetic conditions. (bvsalud.org)
  • Exogenous administration of the Ago2 protein restored erectile function in diabetic mice by reducing reactive oxygen species production-signaling pathways (inducing eNOS Ser1177/NF-κB Ser536 signaling) and improving cavernous endothelial angiogenesis, migration, and cell survival. (bvsalud.org)
  • Coimmunoprecipitation and pull-down assays using mouse cavernous endothelial cells treated with Hsp70 demonstrated physical interactions between Hsp70 and Cse with a dissociation constant of 1.8 nmol/L. CONCLUSIONS: Our findings provide novel and solid evidence that Hsp70 acts through a Cse-dependent mechanism to mediate neurovascular regeneration and restoration of erectile function under diabetic conditions. (bvsalud.org)
  • Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. (ox.ac.uk)
Disease4
  • Angiopathy refers to any disease associated with the blood vessels or the lymph vessels. (naturalcurefor.com)
  • This study aimed at investigating the association between haemostatic biomarkers, proinflammatory, and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. (hindawi.com)
  • We assessed the prevalence of MAU in non-diabetic patients who presented with UA/NSTEMI and the relation of MAU to the severity of coronary artery disease in patients at a cardiac care center in Iraq. (biomedcentral.com)
  • Seventy non-diabetic patients referred to the Iraqi Center for Heart Disease, Baghdad, between November 1st 2010 and June 1st 2011 with the diagnosis of UA/NSTEMI were included in this study. (biomedcentral.com)
Hypertension1
  • In clinical practice MAU is used to evaluate renal impairment in patients suffering from hypertension and in diabetic patients. (biomedcentral.com)
Streptozotocin3
  • Vehicle (saline) or an adenovirus carrying the gene for either hTK (Ad.hTK) or luciferase (Ad.Luc) was injected into left adductor muscles of streptozotocin-induced type 1 diabetic mice 2 weeks before operative occlusion of the ipsilateral femoral artery. (bris.ac.uk)
  • PURPOSE: To assess functional and structural changes in vascular and neural structures associated with diabetic bladder dysfunction (DBD) in the bladders of streptozotocin (STZ)-induced diabetic mice. (bvsalud.org)
  • We injected Hsp70 protein into the penis of streptozotocin (STZ)-induced diabetic mice. (bvsalud.org)
Arterial1
  • Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients. (ox.ac.uk)
Randomly allocated1
  • We randomly allocated 100 patients with diabetic foot into one of four groups. (who.int)
Treatments1
  • A diabetic boot is also helpful in boosting the efficiency of other treatments such as intravenous (IV) antibiotics or medications. (epainassist.com)
Patients6
  • This is a phase III double-blind study to evaluate the efficacy and safety of ALLO-ASC-DFU in patients with Diabetic Foot Ulcer, compared to placebo therapy. (clinicaltrials.gov)
  • This deficit, together with a failure to mount an adequate angiogenic response, might explain why vascular occlusion evolves more severely among diabetic patients. (bris.ac.uk)
  • Streptococcus species [ 3 ], although an in- tion as determined by the Wagner classifi- creasing number of patients have been en- cation. (who.int)
  • diabetic acidoketosis treatment in hospitalized patients without CVD. (promonticelli.it)
  • Objectif: Décrire les signes et l'évolution du paludisme en médecine interne.Patients et méthodes : Etude transversale, descriptive sur 2 ans (1er janvier 2012 au 31 décembre 2013) en médecine interne de l'hôpital de Zone de Comè (Bénin). (bvsalud.org)
  • Etaient inclus, les patients chez qui le paludisme a été diagnostiqué en cours d'hospitalisation. (bvsalud.org)
Therapy1
  • The present study investigated whether prophylactic gene therapy with human tissue kallikrein (hTK) may protect diabetic limbs from the consequences of supervening ischemia. (bris.ac.uk)
Treatment3
  • Generally, doctors prefer to use a diabetic foot treatment known as a total contact cast which creates constant pressure on and around the foot and is irremovable. (epainassist.com)
  • It is a non-diabetic treatment that usually beyond the early stage of their it medicines. (erakey.com)
  • Our study provides new evidence that Ago2 mediation may be a promising therapeutic strategy and a new approach for diabetic ED treatment. (bvsalud.org)
Cardiovascular1
  • 2022 state health benefit plan list of diabetic durable medical care and cardiovascular risk. (neufont.com)
Blood vessels1
  • We found that although Ago2 is highly expressed around blood vessels and nerves, it is significantly reduced in the penis tissue of diabetic mice. (bvsalud.org)
Mice7
  • Ultimately, correction of diabetic endotheliopathy by Ad.hTK allowed proper perfusion recovery as seen in nondiabetic mice. (bris.ac.uk)
  • RESULTS: STZ-induced diabetic mice had significantly lower body weights and significantly higher blood glucose levels. (bvsalud.org)
  • Assessment of bladder function in STZ-induced diabetic mice revealed a nearly 3-fold increase in bladder capacity and intercontractile interval compared to controls. (bvsalud.org)
  • CONCLUSION: STZ-induced diabetic mice exhibit functional and structural derangements in urinary bladder. (bvsalud.org)
  • Here, we aimed to assess whether and how Hsp70 improves erectile function in diabetic mice. (bvsalud.org)
  • Detailed mechanisms were evaluated in WT or Hsp70-Tg mice under normal and diabetic conditions. (bvsalud.org)
  • RESULTS: Using Hsp70-Tg mice or Hsp70 protein administration, we demonstrate that elevated levels of Hsp70 restores erectile function in diabetic mice. (bvsalud.org)
Antibiotics2
  • ABSTRACT The effect of different antibiotics on the outcome of surgical care in the management of diabetic foot was investigated. (who.int)
  • These antibiotics used were the available with diabetic foot, including the effect of broad-spectrum antibiotics. (who.int)
CONCLUSION2
  • Conclusion : Le paludisme est fréquent en Médecine. (bvsalud.org)
  • Conclusion : les connectivites sont peu fréquentes en Médecine interne au Bénin et sont majoritaire-ment représentées par le lupus. (bvsalud.org)
Foot2
  • This is why proactive and preventive foot care is a necessity for diabetics. (epainassist.com)
  • If you have a callus on your foot, then that spot can also develop into a diabetic foot ulcer with time. (epainassist.com)
Types1
  • A diabetic boot is available in two types - removable and irremovable. (epainassist.com)
Development1
  • It is supposed to be involved in the development of all kinds of diabetic angiopathy. (web.app)
Found1
  • No article was found for Diabetic Angiopathies and ATM[original query] . (cdc.gov)
Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Foot Ulcers. - Full Text View -...
Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Foot Ulcers. - Full Text View -... (clinicaltrials.gov)
Prophylactic gene therapy with human tissue kallikrein ameliorates limb ischemia recovery in type 1 diabetic mice<...
Prophylactic gene therapy with human tissue kallikrein ameliorates limb ischemia recovery in type 1 diabetic mice<... (research-information.bris.ac.uk)
Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus
Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus (hindawi.com)
What is a Diabetic Boot & How Does It Help Treat Diabetic Ulcers?
What is a Diabetic Boot & How Does It Help Treat Diabetic Ulcers? (epainassist.com)
Development of Glycogen synthase kinase-3 (GSK-3) inhibitors by GlaxoSmithKline and by Johnson & Johnson (Target of the Month,...
Development of Glycogen synthase kinase-3 (GSK-3) inhibitors by GlaxoSmithKline and by Johnson & Johnson (Target of the Month,... (pharmiweb.com)
Elevation of Plasma Thrombomodulin Level in Diabetic Patients With Early Diabetic Nephropathy | Diabetes | American Diabetes...
Elevation of Plasma Thrombomodulin Level in Diabetic Patients With Early Diabetic Nephropathy | Diabetes | American Diabetes... (diabetesjournals.org)
ACDIS
ACDIS (acdis.org)
Erretinopatia diabetiko - Wikipedia, entziklopedia askea.
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Human Genome Epidemiology Literature Finder|Home|PHGKB
Human Genome Epidemiology Literature Finder|Home|PHGKB (phgkb.cdc.gov)
Aubra EQ Review | The Choice of Your Birth Control Options
Aubra EQ Review | The Choice of Your Birth Control Options (birthcontrolpillsrx.com)
Instruction for use: Wobenzym - DR. DOPING
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Andrew Peter Selwyn, M.D., M.B.Ch.B. | Harvard Catalyst Profiles | Harvard Catalyst
Andrew Peter Selwyn, M.D., M.B.Ch.B. | Harvard Catalyst Profiles | Harvard Catalyst (connects.catalyst.harvard.edu)