An allergic contact dermatitis caused by exposure to plants of the genus Toxicodendron (formerly Rhus). These include poison ivy, poison oak, and poison sumac, all plants that contain the substance urushiol, a potent skin sensitizing agent. (From Dorland, 27th ed)
A genus (formerly part of Rhus genus) of shrubs, vines, or trees that yields a highly allergenic oleoresin which causes a severe contact dermatitis (DERMATITIS, TOXICODENDRON). The most toxic species are Toxicodendron vernix (poison sumac), T. diversilobum (poison oak), and T. radicans (poison ivy). T. vernicifera yields a useful varnish from which certain enzymes (laccases) are obtained.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)
The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States.
Therapy using oral or topical photosensitizing agents with subsequent exposure to light.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
Lipid-laden macrophages originating from monocytes or from smooth muscle cells.
Development of lesions in the lymph node characterized by infiltration of the cortex or paracortex by large collections of proliferating histiocytes and complete or, more often, incomplete necrosis of lymphoid tissue.
VASCULAR DISEASES that are associated with DIABETES MELLITUS.
Conversion into nitroso compounds. An example is the reaction of nitrites with amino compounds to form carcinogenic N-nitrosamines.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Conditions with excess LIPIDS in the blood.
Death and putrefaction of tissue usually due to a loss of blood supply.
A system for classifying patient care by relating common characteristics such as diagnosis, treatment, and age to an expected consumption of hospital resources and length of stay. Its purpose is to provide a framework for specifying case mix and to reduce hospital costs and reimbursements and it forms the cornerstone of the prospective payment system.
A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.
A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.
Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
Substances that reduce the growth or reproduction of BACTERIA.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A specialty concerned with the diagnosis and treatment of foot disorders and injuries and anatomic defects of the foot.
Invasion of the site of trauma by pathogenic microorganisms.
Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90)
A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
The use of green light-producing LASERS to stop bleeding. The green light is selectively absorbed by HEMOGLOBIN, thus triggering BLOOD COAGULATION.
The coagulation of tissue by an intense beam of light, including laser (LASER COAGULATION). In the eye it is used in the treatment of retinal detachments, retinal holes, aneurysms, hemorrhages, and malignant and benign neoplasms. (Dictionary of Visual Science, 3d ed)
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
The ability to detect sharp boundaries (stimuli) and to detect slight changes in luminance at regions without distinct contours. Psychophysical measurements of this visual function are used to evaluate visual acuity and to detect eye disease.
The total area or space visible in a person's peripheral vision with the eye looking straightforward.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
The veins and arteries of the HEART.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
Substances which lower blood glucose levels.
An oral hypoglycemic agent which is rapidly absorbed and completely metabolized.
A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.
A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

Abysmal prognosis of patients with type 2 diabetes entering dialysis. (1/2090)

INTRODUCTION: The importance of non-insulin-dependent diabetes mellitus (type II diabetes) as a leading cause of end-stage renal disease is now widely recognized. The purpose of this study was to assess life-prognosis and its predictors in a cohort of patients newly entering dialysis. MATERIAL AND METHODS: Eighty-four consecutive type II diabetes patients (40% of all patients) starting dialysis between 01/01/95 and 31/12/96 were studied retrospectively, focusing on clinical data at inception and life-prognosis after a mean follow-up of 211 days. Patients were divided into three groups, according to onset of renal failure: acute 11% (9/84), chronic 61% (51/84) and acutely aggravated chronic renal failure 28% (25/84). RESULTS: Patients (mean age 67 years) had long-standing diabetes (mean duration approximately 15 years), heavy proteinuria (approximately 3 g/24h) and diabetic retinopathy (67%). The average creatinine clearance (Cockcroft's formula) was 13 ml/min. Cardiovascular diseases were highly prevalent at the start of dialysis: history of myocardial infarction (26%), angina (36%) and acute left ventricular dysfunction (67%). More than 80% of the patients underwent the first session dialysis under emergency conditions, a situation in part related to late referral to the nephrology division (63% for chronic patients). A great majority of the patients were overhydrated when starting dialysis, as evidenced by the average weight loss of 6 kg, during the first month of dialysis, required to reach dry weight. Nearly 64% of the patients presented high blood pressure (> 140/90 mmHg) when starting dialysis despite antihypertensive therapy (mean: 2.3 drugs). The outcome of this type II diabetes population was dramatic: 32% (27/84) died after a mean follow-up of 211 days, mostly from cardiovascular diseases. The rate of recovery of renal function was low in both the acute and the acutely aggravated renal failure group (30% and 24%, respectively). Of note, iatrogenic nephrotoxic agents accounted for renal function impairment in nearly 30% of patients. CONCLUSION: Our observational study illustrates the high burden of cardiovascular diseases contrasting with sub-optimal cardiovascular therapeutic interventions in type II diabetes patients entering dialysis. Factors aggravating renal failure were mainly iatrogenic, and therefore largely avoidable. Late referral generally implied a poor clinical condition at the start of dialysis.  (+info)

Paraoxonase 192 Gln/Arg gene polymorphism, coronary artery disease, and myocardial infarction in type 2 diabetes. (2/2090)

Paraoxonase is an HDL-associated enzyme implicated in the pathogenesis of atherosclerosis by protecting lipoproteins against peroxidation. Its biallelic gene polymorphism at codon 192 (glutamine/arginine) has been associated with coronary artery disease (CAD). To further evaluate the role of this paraoxonase gene polymorphism for CAD in type 2 diabetes, we determined the paraoxonase genotype in 288 type 2 diabetic patients (170 with and 118 without angiographically documented CAD). The paraoxonase 192 Gln/Arg genotype was assessed using polymerase chain reaction followed by AlwI digestion. The frequency of the Gln allele was 0.656 in the CAD patients and 0.746 in the controls (chi2 = 5.36, P = 0.02). Compared with the Gln/Gln genotypes, the age-adjusted odds ratio for CAD was 1.78 (95% CI 1.08-2.96, P = 0.02) in subjects carrying at least one Arg allele. In the multivariate analysis, this association was even stronger after correction for the possible confounders age, sex, smoking history, and hypertension. Among current and former smokers, the odds ratio (OR) for having CAD among patients with at least one Arg allele was 3.58 (1.45-9.53, P < 0.01). The paraoxonase Arg allele was not associated with the history of myocardial infarction (OR 1.20 [0.73-1.99, NS]), but was with the extent of CAD (OR for three-vessel disease 1.92 [1.15-3.27, P = 0.01]). Our data indicate that the 192 Arg allele of the human paraoxonase gene is a risk factor for CAD but not myocardial infarction in type 2 diabetic patients, a risk factor further modified by cigarette smoking. This risk could possibly be explained by a reduced ability of the paraoxonase Arg isoform to protect lipoproteins against peroxidation.  (+info)

Role of systolic blood pressure and plasma triglycerides in diabetic peripheral arterial disease. The Edinburgh Artery Study. (3/2090)

OBJECTIVE: To determine the risk factors for peripheral arterial disease (PAD) in a diabetic population and to examine whether different levels of these risk factors might explain why diabetic subjects have an increased risk of PAD compared with normal glucose tolerance subjects. RESEARCH DESIGN AND METHODS: There were 1,592 men and women aged 55-74 years selected at random from the age-sex registers of 11 general practices in Edinburgh, Scotland. Subjects underwent a comprehensive medical examination, including assessment for PAD (intermittent claudication on World Health Organization questionnaire or major asymptomatic disease on noninvasive testing) and a glucose tolerance test. RESULTS: Of the subjects, 288 (18.7%) were found to have diabetes or impaired glucose tolerance (IGT). The prevalence of PAD was greater in those with diabetes/IGT (20.6%) compared with those with normal glucose tolerance (12.5%) (odds ratio [OR] 1.64, 95% CI 1.17-2.31). Among the diabetes/IGT group, mean levels of smoking, systolic blood pressure, and triglycerides were higher in subjects with PAD than in those without PAD (P < or = 0.05). Mean levels of systolic blood pressure and plasma triglycerides were also higher in diabetic subjects than in nondiabetic subjects with PAD (P < or = 0.05). In multivariate analysis, those with diabetes/IGT no longer had a significantly higher risk of PAD after adjusting separately for systolic blood pressure (OR 1.22, 95% CI 0.85-1.73) and plasma triglycerides (OR 1.26, 95% CI 0.89-1.79). Simultaneous adjustment for both systolic blood pressure and triglycerides reduced the risk of PAD among diabetic subjects to 1.11 (95% CI 0.78-1.58). CONCLUSIONS: Increased mean levels of triglycerides and systolic blood pressure may help to explain the higher prevalence of PAD in diabetic subjects compared with that in normal glucose tolerance subjects.  (+info)

Increased frequency of G-protein beta 3-subunit 825 T allele in dialyzed patients with type 2 diabetes. (4/2090)

BACKGROUND: A polymorphism (C825T) in exon 10 of the gene encoding the beta 3 subunit of heterotrimeric G proteins (GN beta 3) has recently been described, and the T allele was found to be associated with late-onset hypertension. Because hypertension is a known risk factor for the development of clinically manifest progressive renal disease, we examined the C825T polymorphism in older hemodialysis patients suffering from nondiabetic renal disease or type 2 diabetes with presumed diabetic nephropathy, respectively, and in older healthy controls. METHODS: Genotyping was performed by polymerase chain reaction, followed by restriction enzyme analysis. RESULTS: The study showed that the frequency of the T allele in the nondiabetic patients on dialysis (0.232) was significantly (P < 0.03) lower than in older healthy controls (0.293). In contrast, the frequency was significantly (P < 0.02) higher in older patients with type 2 diabetes on dialysis. No significant change in T-allele frequency was noted in older patients with type 2 diabetes without microangiopathy (0.286). The odds ratios for patients with type 2 diabetes on dialysis versus nondiabetic patients on dialysis were 3.24 (1.3 to 7.9, P < 0.00079) for TT/CC and 1.82 (1.07 to 3.09, P < 0.02) for CT/CC. The respective odds ratios for patients with type 2 diabetes on dialysis versus controls were 2.05 (1.07 to 3.9, P < 0.028) for CT/CC and 1.216 (0.79 to 1.87; P < 0.37) for CT/CC. CONCLUSION: The data do not support a role of the hypertension-associated T allele in the genesis of dialysis-dependent end-stage renal failure in general, but are compatible with a specific role of the T allele in the development or progression of diabetic nephropathy.  (+info)

Hypertension in diet versus pharmacologically treated diabetics: mortality over a 5-year follow-up. (5/2090)

The natural history of non-insulin-dependent diabetes mellitus (NIDDM) differs markedly between patients with diet treated and pharmacologically treated disease. However, the interrelationship between hypertension and these common diabetes types has not been specifically addressed in previous studies. This study was designed to evaluate the prognostic significance and prevalence of hypertension in coronary patients with diet versus pharmacologically treated NIDDM over a 5-year follow-up period. The study sample comprised 11 515 patients aged 45 to 74 years with a previous myocardial infarction and/or anginal syndrome who had been screened but were not included in the Bezafibrate Infarction Prevention study. Among them, 9033 were nondiabetics and 2482, diabetics (987 diet treated and 1495 pharmacologically treated). The prevalence of hypertension among nondiabetics, diet-treated diabetics, and pharmacologically treated diabetics was 31%, 42%, and 43%, respectively. Crude all-cause mortality (CM) was lower in the nondiabetic patients (11.2% versus 22.0%; P<0.001). Among diabetics, 548 patients died: 81 diet treated normotensives (CM 14%); 100 diet-treated hypertensives (CM 24.4%); 205 pharmacologically treated normotensives (CM 24.2%); and 162 pharmacologically treated hypertensive patients (CM 25.0%). Age-adjusted mortality was lowest for the normotensive patients in the diet-treated group and highest for the hypertensive pharmacologically treated patients. Multivariate analysis shows that hypertension is a strong and independent predictor of increased CM in diet-treated but not in pharmacologically treated NIDDM: hazard ratio (HR) was 1.68 (95% confidence interval [CI] 1.24 to 2.29) for the diet-treated versus 1. 01 (95% CI 0.82 to 1.26) for the pharmacologically treated diabetics. The contribution of hypertension to stroke mortality was substantial for both diet treated and pharmacologically treated NIDDM: hazard ratios were 3.17 (95% CI 1.12 to 8.98) and 2.21 (95% CI 0.72 to 6.77), respectively. The increased risk of mortality associated with hypertension in relatively mild diet-treated NIDDM strongly supports the clinical benefit of early blood pressure control among diabetic patients with ischemic heart disease.  (+info)

The Trp64Arg amino acid polymorphism of the beta3-adrenergic receptor gene does not contribute to the genetic susceptibility of diabetic microvascular complications in Caucasian type 1 diabetic patients. (6/2090)

OBJECTIVE: The beta3-adrenergic receptor is involved in regulation of microvascular blood flow. A missense mutation (Trp64Arg) in the beta3-adrenergic receptor gene has been suggested as a risk factor for proliferative retinopathy in Japanese type 2 diabetic patients. The aim of the present study was to evaluate the contribution of this polymorphism to the development of microangiopathic complications in Caucasian type 1 diabetic patients. SUBJECTS AND METHODS: We studied the relationship between the Trp64Arg polymorphism in type 1 diabetic patients with nephropathy (204 men/132 women, age 42.8 +/- 11.0 years, diabetes duration 28 +/- 9 years) and in type 1 diabetic patients with persistent normoalbuminuria (118 men/73 women, age 42.6 +/- 10.2 years, diabetes duration 27 +/- 8 years). Proliferative retinopathy was present in 254 patients (48%), while 66 patients (13%) had no diabetic retinopathy. RESULTS: There were no differences in Trp64Arg genotype distribution between type 1 diabetic patients with diabetic nephropathy and type 1 diabetic patients with normoalbuminuria: 295 (88%)/38 (11%)/3 (1%) vs 161 (84%)/30 (16%)/- had Trp/Trp, Trp/Arg or Arg/Arg genotype respectively. Odds ratio (95% CI) of nephropathy in carriers of the mutation was 0.75 (0.45-1.25). No associations between the Trp64Arg polymorphism and simplex or proliferative retinopathy were revealed either. The frequency of the Arg-allele was 0.069 in patients with proliferative retinopathy, 0.066 in patients with simplex retinopathy and 0.090 in patients with no signs of diabetic retinopathy, NS. CONCLUSIONS: The Trp64Arg polymorphism of the beta3-adrenergic receptor gene does not contribute to the genetic susceptibility to diabetic nephropathy in Caucasian type 1 diabetic patients. Nor does our study support previous findings of an association between this variant and proliferative retinopathy.  (+info)

Influence of diabetes on revascularisation procedures of the aorta and lower limb arteries: early results. (7/2090)

OBJECT: to evaluate the influence of diabetes mellitus on the therapeutic indications and the one-month results in patients with occlusive disease of the aorta and/or lower limbs arteries. MATERIAL: a retrospective study of fully computerised data of 1003 patients (753 men, 250 women) admitted consecutively to our vascular surgery unit over a 5-year period (1992-1996). Of the total, 169 were diabetics (group I) and 834 were non-diabetics (group II). Sixty-two per cent of patients in group I vs. 40% in group II presented with critical ischaemia or trophic changes (p<0.001). RESULTS: 15.4% of patients in group I vs. 4.1% in group II had primary amputation because of irreversible ischaemia or because arterial reconstruction was impossible. Of those who underwent revascularisation, 80% were infrainguinal in group I vs. 50% in group II. Forty-five per cent of patients in group I and 37% in group II had a percutaneous transluminal angioplasty (PTA) and approximately 3% in both groups had a combination of the two techniques. At one month, patients alive without major amputation numbered 64.4% in group I vs. 93.6% in group II, patients alive with major amputation numbered 26.6% in group I vs. 5.5% in group II, and mortality rates were 8.9% in group I vs. 0.8% in group II (P<0.001). CONCLUSIONS: the 5-times higher amputation and 10-times higher mortality rates for diabetics compared to non-diabetics call for better collaborative management of diabetics between general practitioners, vascular surgeons, diabetologists and cardiologists. PTA with a 90% initial success rate is indicated for short lesions even in the presence of limited gangrene.  (+info)

Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation state. (8/2090)

Maternal diabetes mellitus is associated with an increased incidence of congenital abnormalities as well as embryonic and perinatal lethality. In particular, a wide range of cardiovascular abnormalities have been noted in children of diabetic mothers and in the offspring of diabetic animals. The vascular system is the first organ system to develop in the embryo and is critical for normal organogenesis. The organization of mesodermal cells into endothelial and hematopoietic cells and into a complex vascular system is, in part, mediated by a series of specific cell-cell, cell-extracellular matrix, and cell-factor interactions. PECAM-1 expression has been observed during the earliest stages of vasculogenesis, and changes in PECAM-1 tyrosine phosphorylation have been associated with endothelial cell migration, vasculogenesis, and angiogenesis both in vitro and in vivo. In this report we demonstrate that exposure to hyperglycemia during gastrulation causes yolk sac and embryonic vasculopathy in cultured murine conceptuses and in the conceptuses of streptozotocin-induced diabetic pregnant mice. In addition, we correlate the presence of yolk sac and embryonic vasculopathy with the failure of PECAM-1 tyrosine dephosphorylation during the formation of blood islands/vessels from clusters of extra-embryonic and embryonic angioblasts in the murine conceptus using both in vitro and in vivo models. The importance of these findings in the development of vasculopathy in the offspring of diabetic mothers and the potential effects and benefits of glucose regulation during the periods of vasculogenesis/angiogenesis in embryonic development are discussed.  (+info)

An Experimental study of Macroangiopathy, a common complication of Diabetes Mellitus, with Ayurveda perspective Prof. Ojha S. N. M.D.(Ayu.) Ph.D. Principal Dr. D.Y Patil college of ayurved and research centre Pimpri pune 18 . ► The prevalence of macroangiopathy is increased in Diabetes Mellitus. ► Endothelial cell injury is thought to be an early event leading to atherosclerosis…
Macrovascular disease is a disease of any large (macro) blood vessels in the body. It is a disease of the large blood vessels, including the coronary arteries, the aorta, and the sizable arteries in the brain and in the limbs. This sometimes occurs when a person has had diabetes for an extended period of time. Fat and blood clots build up in the large blood vessels and stick to the vessel walls. Three common macrovascular diseases are coronary disease (in the heart), cerebrovascular disease (in the brain), and peripheral vascular disease (in the limbs) Macrovascular disease (macroangiopathy) refers to atherosclerosis. Atherosclerosis is a form of arteriosclerosis (thickening and hardening of arterial walls), characterized by plaque deposits of lipids, fibrous connective tissue, calcium, and other blood substances. Atherosclerosis, by definition, affects only medium and large arteries (excluding arterioles). Macrovascular disease is associated with the development of coronary artery disease, ...
To the Editor:. We have read with interest the article by Wilcox et al,1 in which they demonstrated the positive effect of pioglitazone on stroke recurrence in patients with type 2 diabetes mellitus (DM). However, we would like to stress a particular concern regarding a basic concept in the difficult question of DM and stroke. In this study, as in other previous studies, stroke is considered a macrovascular event in diabetic patients, but is this statement true? Traditionally, retinopathy, neuropathy, and nephropathy have been designated microvascular complications of DM, and stroke, myocardial infarction and gangrene are termed macrovascular complications.2 However, we think it is time to change this commonly accepted concept.. The pathophysiology of cerebrovascular disease in patients with DM is not fully characterized, but both large and small blood vessels seem to be affected. Thus, the etiology of strokes in diabetics is frequently microvascular disease from fibrinoid necrosis, which causes ...
This study will compare the effects of olmesartan medoxomil and amlodipine on beta-cell function and the incidence diabetic angiopathy in type 2 diabetic
Symptoms of Microvascular Complications of Diabetes, Susceptibility to, 2 including 5 medical symptoms and signs of Microvascular Complications of Diabetes, Susceptibility to, 2, alternative diagnoses, misdiagnosis, and correct diagnosis for Microvascular Complications of Diabetes, Susceptibility to, 2 signs or Microvascular Complications of Diabetes, Susceptibility to, 2 symptoms.
Purpose: : Human kallistatin is a secreted, glycoprotein and a serine proteinase inhibitor that specifically binds to tissue kallikrein, and it has multiple functions, e.g., anti-angiogenic, anti-fibrogenic, anti-inflammatory, and anti-oxidative activities independent of its direct tissue kallikrein inhibition. It is produced mostly by the liver, but is also secreted by the retina and blood vessels. Human kallistatin is decreased in the vitreous space of diabetics with retinopathy versus that in controls. Recently, our group reported that serum kallistatin is significantly elevated in type 1 diabetic patients with microvascular complications, compared to non-diabetic controls or diabetic patients without complications. Our hypothesis is that average serum kallistatin may be increased in the sera of type 2 diabetic patients compared to non-diabetic controls and type 2 patients without microvascular complications. Methods: : We collected serum samples from patients at the University of Oklahoma ...
Why this is important:- Many people with critical limb ischaemia, especially those with diabetic vascular disease, also have disease of the infra-geniculate (below the knee) arteries in the calf. For many years, the standard of care has been bypass surgery. Although such surgery may be associated with significant morbidity, the resulting long-term amputation-free survival rates are generally good. In recent years there has been a trend towards treating infra-geniculate disease with angioplasty, on the grounds that it is associated with less morbidity than surgery. However, this change in practice is not evidence-based, and serious concerns remain about the durability of angioplasty in this anatomical area. A multicentre, randomised controlled trial with a full health economic analysis is required to address this. The primary endpoint should be amputation-free survival, with secondary endpoints including overall survival, health-related quality of life, healing of tissue loss, and relief of ...
1. Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th ed. Diabetes Res Clin Pract 2019;157:107843-107843.. 2. Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999;104:787-794.. 3. American Diabetes Association. 10. Cardiovascular disease and risk management: Standards of medical care in diabetes-2021. Diabetes Care 2021;44:Suppl 1:S125-S150.. 4. Das SR, Everett BM, Birtcher KK, et al. 2020 expert consensus decision pathway on novel therapies for cardiovascular risk reduction in patients with type 2 diabetes: a report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol 2020;76:1117-1145.. 5. Orasanu G, Plutzky J. The pathologic continuum of diabetic vascular disease. J Am Coll ...
Prolonged exposure to hyperglycaemia may contribute to the development of microvascular complications and loss of ~-cell viability in diabetes. In the past decade it has become clear that glucose itself acts as a signalling molecule via the induction of candidate genes which contribute to the disease process. ChREBP is a glucose responsive transcription factor with a response element in the promoter region of various genes, and is one of the targets through which glucose exerts its effect on gene expression. Both aldose reductase and thioredoxin interacting protein are under ChREBP mediated, glucose dependent regulation. Aldose reductase has been indicated in the process of diabetic complications, whereas the TXNIP protein is described as a central proapoptotic factor in the loss of ~-cell viability and is also emerging as a candidate gene for microvascular complication of diabetes. The current study has investigated the role of ChREBP, AR and TXNIP in these disease processes by collecting PBMCs ...
Diabetes mellitus (DM) is one of the commonest global noncommunicable health-care problem, carrying a predicted pandemic score of 366 million population by 2030.
Treatment strategy for type 2 diabetes from the perspective of systemic vascular protection and insulin resistance Kazunori UtsunomiyaDivision of Diabetes, Metabolism and Endocrinology, Jikei University School of Medicine, Tokyo, JapanAbstract: This paper provides an update on the mechanisms of vascular impairment associated with insulin resistance and the pathogenesis of diabetic nephropathy and peripheral artery disease (PAD). It also considers the optimal treatment strategies for systemic vascular protection in light of recent findings. This area is of major clinical importance given the ongoing global epidemic of type 2 diabetes and the pivotal role played by insulin resistance in the mechanism of vascular impairment that manifests as macroangiopathy and microangiopathy. Timely diagnosis and intervention is critical in patients with systemic arteriosclerotic disease. Therefore, treatment strategies are aimed not only at targeting the presenting pathology, but also at reducing the risk of
Prognosis of Microvascular Complications of Diabetes, Susceptibility to, 7 including probable outcomes, duration, recurrence, complications, deaths, and survival rates.
Intriguingly, these mechanisms resemble those accountable for the development of macrovascular problems this sort of as atherosclerosis. Consequently,RO4929097
Hypertension and dyslipidemia, among other risk factors for CVD, are common in subjects with diabetes. Together, they can explain most, but not all, of the excess of risk of CVD in patients affected by the disease. High blood glucose has long been considered a risk factor for developing atherosclerosis, but data directly relating this alteration to the development and progression of CVD are conflicting. In this context, several glucose-lowering trials in both type 1 and type 2 diabetes showing significant reductions in microvascular complications have systematically failed to achieve significant reductions in macrovascular events (5). Nevertheless, it should also be mentioned that some systematic reviews and metanalysis performed in type 1 and type 2 diabetes (in the case of type 1 diabetes including some studies with few subjects and none or very small number of CV events) have suggested that attempts to improve glycemia reduce the incidence of CVD (9,10).. Before going through proper trials ...
In this study, we show for the first time that sitagliptin increases EPCs in type 2 diabetic patients, as an ancillary effect of DPP-4 inhibition, possibly mediated by the SDF-1α/CXCR4 axis.. Experimental studies demonstrate that EPCs stimulate endothelial repair and angiogenesis (1). These cells are reduced in diabetic patients at an early stage and are further impaired in patients with macro-/microvascular complications (2,8,9). Low baseline progenitor cell levels predict adverse outcomes of macro- and microangiopathy (3,4,10), and EPC reduction is now considered a novel route to development and worsening of diabetes complications. In response to ischemia, SDF-1α is upregulated and, upon binding to its receptor CXCR4, stimulates the bone marrow to release EPCs that are eventually recruited at ischemic sites (7). In diabetic animals a blunted SDF-1α response to ischemia is associated with inhibited progenitor cell release from the bone marrow and defective postischemic angiogenesis (11). ...
Recent estimates indicate there were 171 million people in the world with diabetes in the year 2000 and this is projected to increase to 366 million by 2030-. Diabetes is a condition primarily defined by the level of hyperglycaemia giving rise to risk of microvascular damage (retinopathy, nephropathy and neuropathy). It is associated with reduced life expectancy, significant morbidity due to specific diabetes related microvascular complications, increased risk of macrovascular complications (ischaemic heart disease, stroke and peripheral vascular disease), and diminished quality of life ...
Therapy in most individuals with type 1 or type 2 diabetes should be targeted to achieve an A1C ≤7.0% in order to reduce the risk of microvascular [Grade A, Level 1A (1,2) ] and, if implemented early in the course of disease, macrovascular complications [Grade B, Level 3 (3,4) ...
Objective: Although coronary artery disease (CAD) is the leading cause of death in type 2 diabetic patients, it is frequently asymptomatic. Myocardial perfusion imaging (MPI) is reported to show ischemia in a significant number of asymptomatic diabetic patients. We studied the prevalence and severity of myocardial perfusion defects in asymptomatic diabetic patients and its clinical impact. Methods and patients: One hundred thirty consecutive asymptomatic patients, aged 35-65 years with type 2 diabetes mellitus and with no history of CAD and no cardiac symptoms were recruited in the study. Echocardiography, electrocardiography (ECG), routine laboratory tests and exercise treadmill test (ETT) were performed and patients with weakly positive or negative ETT underwent Dipyridamole MPI. Patients with positive ETT were referred to coronary angiography. Patients were followed for at least 17 months (mean 21.7 months) and any cardiac event was recorded. Results: We studied 81 female and 49 male patients with
Diabetic microvascular disease The 3 main manifestations of diabetic microvascular disease, retinopathy, nephropathy, and neuropathy are reviewed.. Retinopathy: Diabetic microvascular disease is strongly associated with hyperglycemia. In the range of chronic hyperglycemia commonly seen in practice, there is an 11-fold increase in retinopathy compared to a 2-fold increase in coronary artery disease. Despite the importance of hyperglycemia, some patients may develop early evidence of retinopathy up to 7 years before the development of Franks type 2 diabetes mellitus, indicating the contribution of insulin resistance.. In addition to the severity of hyperglycemia and the duration of diabetes mellitus, other factors associated with retinopathy include hypertension, smoking, and dyslipidemia. These and other pathophysiological mechanisms, including insulin resistance and inflammation, contribute to the diabetic microvascular disease process.. The early histopathological sign of retinopathy related ...
Diabetic Microvascular Complications are 3 main manifestations of microvascular disease, retinopathy, nephropathy, and neuropathy are reviewed.
Red blood cell count as an indicator of microvascular complications in Chinese patients with type 2 diabetes mellitus Zhan-Sheng Wang,1,2 Zhan-Chun Song,1 Jing-Hui Bai,1 Fei Li,3 Tao Wu,1 Ji Qi,2 Jian Hu11Department of Cardiology, First Affiliated Hospital of China Medical University, 2Second Department of Cardiology, Fourth People's Hospital of Shenyang, Shenyang, 3Department of Cardiology, Shenzhou Hospital of Shenyang Medical College, Shenyang, People's Republic of ChinaBackground: Rheological disorders of red blood cells (RBC) and decreased RBC deformability have been involved in the development of diabetic microangiopathy. However, few studies have evaluated the association of RBC count with microvascular complications in patients with type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the association of RBC count with microvascular complications in patients with T2DM.Methods: This study involved 369 patients with T2DM: 243 with one or more microvascular
The UK prospective diabetes study (UKPDS), a clinical trial of a policy of intensive control of blood glucose after diagnosis of type 2 diabetes, which achieved a median haemoglobin A1c (HbA1c) of 7.0% compared with 7.9% in those allocated to conventional treatment over a median 10.0 years of follow up, has shown a substantial reduction in the risk of microvascular complications, with a reduction in the risk of myocardial infarction of borderline significance.1 Complementary information for estimates of the risk of complications at different levels of glycaemia can be obtained from observational analyses of data during the study.. In patients with type 2 diabetes previous prospective studies have shown an association between the degree of hyperglycaemia and increased risk of microvascular complications, 2 3 sensory neuropathy, 3 4 myocardial infarction, 2 5 6 stroke,7 macrovascular mortality,8-10 and all cause mortality. 9 11-14 Generally, these studies measured glycaemia as being high or low or ...
The UK prospective diabetes study (UKPDS), a clinical trial of a policy of intensive control of blood glucose after diagnosis of type 2 diabetes, which achieved a median haemoglobin A1c (HbA1c) of 7.0% compared with 7.9% in those allocated to conventional treatment over a median 10.0 years of follow up, has shown a substantial reduction in the risk of microvascular complications, with a reduction in the risk of myocardial infarction of borderline significance.1 Complementary information for estimates of the risk of complications at different levels of glycaemia can be obtained from observational analyses of data during the study.. In patients with type 2 diabetes previous prospective studies have shown an association between the degree of hyperglycaemia and increased risk of microvascular complications, 2 3 sensory neuropathy, 3 4 myocardial infarction, 2 5 6 stroke,7 macrovascular mortality,8-10 and all cause mortality. 9 11-14 Generally, these studies measured glycaemia as being high or low or ...
The burden of diabetic vasculopathy on the global population is enormous and ever growing. Besides the well-known microvascular complications in type 2 diabetes (T2DM), there is a growing epidemic of macrovascular complications. People with T2DM have a higher risk of death from cardiovascular (CV) diseases than persons without diabetes. Like diabetes, impaired glucose tolerance (IGT) individuals also have associated risk of developing macrovascular complications. This calls for an early detection and intervention in patients with T2DM as well as IGT, not only to delay progression of IGT to T2DM but also to treat early macrovascular diseases in both groups. The traditional therapeutic approaches of T2DM emphasise on glycaemic control, which limits microvascular diseases but lacks an established benefit in macrovascular diseases. Type 2 diabetes is a metabolic disorder characterised by dyslipidaemia, hypertension, and hypercoagulability in addition to hyperglycaemia and hyperinsulinaemia. Each of ...
Clinical and biochemical variables and prevalence of complications at diagnosis of diabetes were assessed in 5098 Type 2 diabetic patients in the UK Prospective Diabetes Study of whom 82% were white Caucasian, 10% Asian of Indian origin, and 8% Afro-Caribbean. The Asian patients were (p | 0.001) younger (mean age 52.3, 47.0, 51.0 years), less obese (BMI 29.3, 26.7, 27.9 kg m-2), had a greater waist-hip ratio, lower blood pressure (systolic 145, 139, 144, diastolic 87, 86, 89 mmHg) and prevalence of hypertension. They were more often sedentary (19, 39, 15%), more often abstained from alcohol (21, 55, 25%) and had a greater prevalence of first degree relatives with known diabetes (36, 44, 34%). The Afro-Caribbean patients had (p | 0.001) higher fasting plasma glucose (11.9, 11.3, 12.5 mmol l-1), more severely impaired beta-cell function (45, 35, 28% normal) and less impaired insulin sensitivity (23, 19, 27% normal) by homeostasis model assessment, lower triglyceride (1.8, 1.8, 1.3 mmol l-1), and higher
Clinical and biochemical variables and prevalence of complications at diagnosis of diabetes were assessed in 5098 Type 2 diabetic patients in the UK Prospective Diabetes Study of whom 82% were white Caucasian, 10% Asian of Indian origin, and 8% Afro-Caribbean. The Asian patients were (p | 0.001) younger (mean age 52.3, 47.0, 51.0 years), less obese (BMI 29.3, 26.7, 27.9 kg m-2), had a greater waist-hip ratio, lower blood pressure (systolic 145, 139, 144, diastolic 87, 86, 89 mmHg) and prevalence of hypertension. They were more often sedentary (19, 39, 15%), more often abstained from alcohol (21, 55, 25%) and had a greater prevalence of first degree relatives with known diabetes (36, 44, 34%). The Afro-Caribbean patients had (p | 0.001) higher fasting plasma glucose (11.9, 11.3, 12.5 mmol l-1), more severely impaired beta-cell function (45, 35, 28% normal) and less impaired insulin sensitivity (23, 19, 27% normal) by homeostasis model assessment, lower triglyceride (1.8, 1.8, 1.3 mmol l-1), and higher
INTRODUCTION : Type 2 diabetes mellitus is a pandemic associated with disturbance inhaemostasis that could contribute to the development of diabetic vascular disease and accelerated atherosclerosis. In this population, hypercoagulation is prevalent, as well as pathological changes to erythrocytes. This is mainly due to upregulated circulating inflammatory markers. MATERIALS AND METHODS : Here we looked at tissue factor (TF) levels using ELISA, in a sample of diabetics, with and without cardiovascular complications. Diabetic subjects were recruited from the diabetic clinic at Steve Biko Academic Hospital, Pretoria, South Africa. 20 diabetics with cardiovascular disease and 22 without were enrolled to participate. RESULTS AND CONCLUSION : TF levels were significantly elevated in both diabetic groups when compared to the controls. We suggest that pathologic plasma TF activity, as marker of increased propensity of clot pathology, should be investigated. Agents that might lower TF levels might also ...
The UK Prospective Diabetes Study (UKPDS) is a multi-centre, prospective, randomised, intervention trial of 5100 newly-diagnosed patients with Type 2 (non-insulin-dependent) diabetes mellitus which aims to determine whether improved blood glucose control will prevent complications and reduce the associated morbidity and mortality. Newly presenting Type 2 diabetic patients aged 25-65 years inclusive, median age 53 years, median body mass index 28 kg/m2 and median fasting plasma glucose 11.3 mmol/l, were recruited and treated initially by diet. Ninety five percent remained hyperglycaemic (fasting plasma glucose greater than 6 mmol/l) and were randomly allocated to different therapies. In the main randomisation, those who were asymptomatic and had fasting plasma glucose under 15 mmol/l were allocated either to diet policy, or to active policy with either insulin or sulphonylurea aiming to reduce the fasting plasma glucose to under 6 mmol/l. Over 3 years, the median fasting plasma glucose in those allocated
The objective of the U.K. Prospective Diabetes Study is to determine whether improved blood glucose control in type II diabetes will prevent the complications of diabetes and whether any specific therapy is advantageous or disadvantageous. The study will report in 1998, when the median duration from randomization will be 11 years. This report is on the efficacy of therapy over 6 years of follow-up and the overall incidence of diabetic complications. Subjects comprised 4,209 newly diagnosed type II diabetic patients who after 3 months diet were asymptomatic and had fasting plasma glucose (FPG) 6.0-15.0 mmol/l. The study consists of a randomized controlled trial with two main comparisons: 1) 3,867 patients with 1,138 allocated to conventional therapy, primarily with diet, and 2,729 allocated to intensive therapy with additional sulfonylurea or insulin, which increase insulin supply, aiming for FPG ,6 mmol/l; and 2) 753 obese patients with 411 allocated to conventional therapy and 342 allocated to ...
The objective of the U.K. Prospective Diabetes Study is to determine whether improved blood glucose control in type II diabetes will prevent the complications of diabetes and whether any specific therapy is advantageous or disadvantageous. The study will report in 1998, when the median duration from randomization will be 11 years. This report is on the efficacy of therapy over 6 years of follow-up and the overall incidence of diabetic complications. Subjects comprised 4,209 newly diagnosed type II diabetic patients who after 3 months diet were asymptomatic and had fasting plasma glucose (FPG) 6.0-15.0 mmol/l. The study consists of a randomized controlled trial with two main comparisons: 1) 3,867 patients with 1,138 allocated to conventional therapy, primarily with diet, and 2,729 allocated to intensive therapy with additional sulfonylurea or insulin, which increase insulin supply, aiming for FPG ,6 mmol/l; and 2) 753 obese patients with 411 allocated to conventional therapy and 342 allocated to ...
Diabetes mellitus is characterized by a widespread endothelial dysfunction20 and a 2- to 3-fold increased risk of developing cardiovascular diseases. As previously highlighted by our group, circulating blood cells in diabetes are subjected to many biochemical alterations attributable to the high oxidative stress and the unfavorable vascular environment.21,22. The present study demonstrates that number and function of circulating EPCs are profoundly altered in type 2 diabetic patients with PAD compared with diabetic patients without PAD. Moreover, we show strong correlations between circulating EPC levels and the severity of carotid and lower extremity arterial disease.. In this work we have used 2 independent methods to study endothelial progenitors: flow cytometry of fresh blood and ex vivo culture. Flow cytometry is considered the gold standard for quantitative enumeration of EPC, being sensitive, precise and reproducible23: using this technique, we have defined EPCs by the surface expression ...
Persistent Problems of Diabetes Mellitus Flashcards. Kidneys might have a problem removing potassium in the event that renal deficiency is available.. MALE IMPOTENCE can be a common long lasting problem of diabetes. Macrovascular Complications Of Diabetes Mellitus Include Quizlet -- In the event that discovered early, and blood sugar brought in check, these types of
Angela Manning lost her left leg to diabetic vascular disease. But it didnt stop her from wearing chunky, colorful, attention-grabbing high heels.
Insulin Resistance in Type 1 Diabetes Mellitus and its Association with Patients Micro and Macrovascular Complications, Sex Hormones and Other Clinical Data
Archives of Ophthalmology 2004;122:1631-1640. Published:Nov-2004. PMID:15534123. doi:10.1001/archopht.122.11.1631. A model to estimate the lifetime health outcomes of patients with type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS 68) ...
Medical Decision Making 2002;4:340-349. Published:Aug-2002. PMID:12150599. doi:10.1177/0272989X0202200412. Risk of Stroke in Type 2 Diabetes Estimated by the UK Prospective Diabetes Study Risk Engine ...
With over 280 million people suffering from diabetes mellitus, it is globally one of the most common non-communicable diseases [1,2]. The increasing prevalence of both types of diabetes [3,4], especially in low-income countries, poses a challenge to healthcare and to society at large. Diabetes is associated with microangiopathy, such as retinopathy, nephro-pathy, and peripheral (poly)neuropathy, as well as macroangiopathy. More recently, awareness has been increasing that diabetes also affects the brain [5]. Although this was recognized in the early 1920s [6], and further studied in post mortem research in the 1960s [7,8], in the past decade, with advances in neuroimaging techniques, this research field has been growing. Patients with diabetes show cognitive decrements in a wide range of functions, such as working memory, information processing speed, and executive functions, including mental flexibility and verbal fluency [9-11]. In addition, changes compared with control subjects have been ...
Thank you for your interest in spreading the word about Clinical Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Type 2 diabetes mellitus is increasing in prevalence and is a common cause of morbidity and mortality. In persons with diabetes, vascular complications are the usual cause of adverse outcomes, and the latter often are divided into macrovascular (i.e., coronary artery disease, cerebrovascular disease, and peripheral vascular disease) and microvascular (i.e., retinopathy, nephropathy, and neuropathy). Tight glucose control reduces microvascular complications but does not affect macrovascular changes. Controlling cardiovascular risk factors in persons with diabetes can reduce macrovascular complications, and guidelines for the management of hypercholesterolemia in patients with type 2 diabetes have been formulated by the American College of Physicians (ACP).. Snow and colleagues in the Clinical Efficacy Assessment Subcommittee of the ACP developed guidelines for hyperlipidemia management in type 2 diabetes based on a systematic review of the evidence performed by Vijan and colleagues. Because there ...
Prognosis of Diabetes mellitus depends from an optimal metabolic control, as shown by large clinical studies like DCCC. Patients under continued hyperglycemic conditions are prone to high risk for developing complications like diabetic angiopathy, neuropathy, retinopathy or nephropathy. ON the other hand, hypoglycemia bears high acute threats. ...
Diabetes is one of the key risk factors for CAD, and its prevalence has increased over the last few years. The analysis of cultured EPCs and CD34+KDR+ cells and their functions in clinical studies identified type II diabetes as a major determinant of impairment. Patients with type I and type II diabetes exhibit lower number of CD34+KDR+ EPCs or cultured EPCs,14-16 and the reduced number of CD34+KDR+ cells was associated with the severity of diabetic vasculopathy.17. These results were consistent with animal experiments with obese diabetic mice (Lerdb), in which the function of progenitor and proangiogenic cells were impaired.18,19 Of note, diabetes was not only associated with a reduction of cell numbers but led to a profound impairment of cell functionality such as reduced migration toward cytokines, reduced proliferation, and reduced ability of the cells to integrate into vascular networks in vitro.9,15 The impaired migratory response resembled the previously shown diminished response of ...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Diabetic shoes need a special stitch in its making, as the requirements of diabetic patients are unique. Here look at our 10 Best & Comfortable Diabetic Shoes.
Diabetic patients are considered to be at increased risk of preoperative morbidity and mortality because of the involvement of their vital organs and the auton...
Introduction: Asymptomatic diabetic patients are at increased risk of cardiovascular complications. Myocardial perfusion scan may be effective in risk evaluation in this population. Methods: 106 asymptomatic diabetic patients (age: min: 37, max: 82, mean: 57.73±8.88), including 56 females (52.8%) and 50 males (47.2%) were enrolled in the study. Myocardial perfusion scintigraphy was performed by Gated Single Photon Emission Computed Tomography (Gated-SPECT) method. Perfusion and function status was evaluated by qualitative and semi-quantitative parameters. Results: By visual analysis totally 40 out of 106 patients (37.7%) showed abnormal scan. From which, 26(24.5%) showed involvement in one, 13(12.3%) in two, and 1(0.9%) in all three vessel territories. By semi-quantitative method, from 103 patients, 28 (27.2%) were abnormal and 75 (72.8%) were normal. From all the asymptomatic diabetic patients, 11 patients (10.4%) had dilated left ventricles. Transient Ischemic Dilation (TID) was noted in 10
TY - JOUR. T1 - Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy. AU - Cui, Xinglong. AU - Kushiyama, Akifumi. AU - Yoneda, Masayasu. AU - Nakatsu, Yusuke. AU - Guo, Ying. AU - Zhang, Jun. AU - Ono, Haruya. AU - Kanna, Machi. AU - Sakoda, Hideyuki. AU - Ono, Hiraku. AU - Kikuchi, Takako. AU - Fujishiro, Midori. AU - Shiomi, Masashi. AU - Kamata, Hideaki. AU - Kurihara, Hiroki. AU - Kikuchi, Masatoshi. AU - Kawazu, Shoji. AU - Nishimura, Fusanori. AU - Asano, Tomoichiro. PY - 2010/1/1. Y1 - 2010/1/1. N2 - The differentiation of macrophages into cytokine-secreting foam cells plays a critical role in the development of diabetic angiopathy. J774.1, a murine macrophage cell line, reportedly differentiates into foam cells when incubated with oxidized LDL, ApoE-rich VLDL or WHHLMI (myocardial infarction-prone Watanabe heritable hyperlipidemic) rabbit serum. In this study, serum samples from Type 2 diabetic patients were added to the medium with J774.1 cells ...
Background: As one of the most frequent risk factors for cardiovascular disease, type 2 diabetes mellitus (T2DM) is one of the largest causes of death. However, an acute cardiac presentation is not uncommon in diabetic patients, and the current investigative approach remains often inadequate. The aim of our study was to retrospectively stratify the risk of asymptomatic T2DM patients using low-dose 640-slice coronary computed tomography angiography (CCTA). Materials and methods: CCTA examinations of 62 patients (mean age, 65 years) with previous diagnosis of type 2 diabetes and without cardiac symptoms were analyzed. Image acquisition was performed using a 640-slice CT. Per-patient, per-vessel and per-plaque analyses were performed. Stratification risk was evaluated according to the ESC guidelines. The patients were followed up after 2.21 ± 0.56 years from CCTA examination. Results: Coronary artery disease (CAD) was found in 58 patients (93.55%) presenting 290 plaques. Analysis of all samples ...
This scientific statement provides an updated summary and review of the pathogenesis and effects of diabetic microvascular disease.
Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5 million Chinese adults.
Health,lar and macrovascular complications. It likely reflects problems in en...The researchers found that the decreased plasma thiamine concentration...The researchers feel that important areas for future study are: confir......,Researchers,find,vitamin,B1,deficiency,key,to,vascular,problems,for,diabetic,patients,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Metabolic abnormalities, including hyperglycemia, obesity, hypertension, and dyslipidemia, are frequently present inpatients with type 2 diabetes and are risk factors for both microvascular and macrovascular disease. The risk is further increased in patients with microalbuminuria. Clinical trial evidence has shown that reducing plasma glucose levels, blood pressure, or both slows the development or progression of microvascular complications. Individual trials have focused on 1 or, at most, 2 interventions. However, in routine clinical practice, multifactorial interventions are often needed to improve the many possible metabolic derangements. Gaede and colleagues study shows the benefits of intensively managing type 2 diabetes. A major strength of the study is its pragmatic design that compares multifactorial interventions (similar to those recommended by the American Diabetes Association) in a diabetes center with routine care by primary care providers. An impressive reduction in the ...
Drug-eluting stents (DES) implantation has been demonstrated to dramatically reduce restenosis and repeat revascularisation (RR) in diabetic patients. However, diabetic patients are prone to an accelerated atherosclerotic process and the impact of atherosclerotic disease progression (ADP) on RR and mid-term clinical outcome after DES implantation is not well known To determine whether RR in diabetic patients treated with prior DES is the result of either DES restenosis or native progression of atherosclerotic disease in the coronary vasculature, and to evaluate the impact of ADP on the mid-term clinical outcome. We followed 316 consecutive diabetic patients (227 men, age 69 ± 9 years) treated between June 2005 and September 2006 with at least one DES. Of these patients, 260 (82%) had a multivessel coronary disease, 148 (41%) had previous coronary revascularisation and 104 (32%) had insulin-dependent diabetes. During the follow-up (mean 590 ± 194 days) the cumulative incidence of major adverse ...
The DECIDE study will identify whether cardiovascular complication rates (the composite rate of myocardial infarction (MI), Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Grafting (CABG), stroke, carotid endarterectomy, peripheral revascularization, and peripheral amputation) are lower in patients who participate in managed diabetes care by ADEC in comparison to provincial and national rates. Comparison statistics will be provided by the Institute of Evaluative Sciences (ICES) Atlas 2003 and other Diabetes studies such as the 2005 DICE study. Complications such as nephropathy and retinopathy will be documented, along with hospitalization rates and all cause mortality. Clinical outcomes relevant to diabetes management such as blood pressure and lipids will also be compared ...
Impaired glucose tolerance (IGT) serves as a marker for the state of insulin resistance and predicts both largeand small-vessel vascular complications, independent of a patients progression to diabetes. Patients with IGT are at significantly increased risk for death and morbidity due to myocardial infarction, stroke, and large-vessel occlusive disease. IGT is more predictive of cardiovascular morbidity than impaired fasting glucose, probably because it is a better surrogate for the state of insulin resistance. IGT is also independently associated with traditional microvascular complications of diabetes, including retinopathy, renal disease, and polyneuropathy, which are the topics of this review. Inhibition of nitric oxide- mediated vasodilation, endothelial injury due to increased release of free fatty acids and adipocytokines from adipocytes, and direct metabolic injury of endothelial and end-organ cells contribute to vascular complications. Early detection of IGT allows intensive diet and ...
In this retrospective study, we evaluated the medical records of 557 patients with type 2 diabetes admitted to the Endocrinology Outpatient Clinic from January to March 2010 and 112 healthy controls randomly selected from individuals admitted to the hospital for a check-up and who had a laboratory result for serum 25-OH vitamin D concentrations at screening. The levels of 25-OH vitamin D in patients with type 2 diabetes and the relationship between 25-OH vitamin D deficiency and microvascular complications were investigated. ...
Conversely, those patients with microvascular complications, e.g. retinopathy, neuropathy, and nephropathy, should be treated more aggressively. Microvascular complications seem to correlate more strongly with higher AIC. Macrovascular disease, e.g.cardiovascular events, meaning acute coronary syndromes, stroke, and peripheral arterial disease, seem to correlate less with aic reduction, though risk may be diminished not only with lifestyle changes, but also certain diabetes medications. Metformin, certain sodium-glucose co-transporter 2 inhibitors inhibitors, and glucagon-like peptide1 agonists have been shown to reduce cardiovascular events in some settings ...
Statistical analyses used logistic regression stratified by treatment group and an exhaustive-search approach based on the likelihood score statistic.. Results: A total of 12 variables were significantly associated with any new first microvascular disease arising during the trial. Age, duration and control of diabetes (HbA1c), blood pressure, and prior cardiovascular disease (CVD) were strongly and independently associated with the development of microvascular disease. The on-study risk model for new disease over 5 years fitted relatively well, with a C-statistic of 0.652. No treatment-by-variable interactions were found. A simplified risk model developed for routine clinical practice maintained the predictive power.. Conclusions: Routinely measured clinical and biochemical variables can successfully identify most patients at high risk of developing microvascular disease. A simplified risk model may be usefully applied in clinical practice.. ...
Green recently investigated 14,671 patients with type 2 diabetes mellitus (T2DM) treated for 3 years with sitagliptin, a dipeptidyl peptidase (DPP)-4 inhibitor
DIABETIC ANGIOPATHY Prolonged and, especially, should be practiced as often propranolol alcohol use possible under the direction of the ophthalmologist. Damasio. 16. These propranollo develop signs and symptoms within the first decade and generally survive into adulthood.
(HealthDay)-In patients with type 2 diabetes, age or age at diabetes diagnosis and diabetes duration are independently associated with macrovascular events and death, but only duration of disease is independently associated ...
Rate of microvascular complications and myocardial infarction in the UKPDS according to the mean updated systolic blood pressure over the entire study duration (corrected for age, gender and ethnicity). Modified from [6 ...
A new kit has been developed that will allow doctors to find out within minutes if diabetic patients are suffering from inflammation. Current procedures require patients to wait for several hours for the results obtained from the conventional full blood count test. Type 2 diabetes is the most common and is usually treated with lifestyle…
Discussion The results of this study indicate a rapid raise in the number of adults who meet the criteria for T2DMduring the first decade of the 21st century. These patients are currently receiving treatment at the primary care level. This rapid rise in such a short period of time is particularly disturbing because it suggests that large changes at the population level can occur in a relatively short period of time. If there is no coordinated response to arrest this increase in T2DM, the consequences are formidable. Increases in health expenditure, diabetic complications and cardiovascular morbidity and mortality are all likely to occur. These findings are particularly problematic given the strong association of T2DMand an array of both micro and macrovascular complication. Therefore, these findings have important implications for the debate on introducing stratergies such as health checks and other public health interventions to arrest the progression to overt diabetes.An effective and ...
... experimental studies in dogs showed that meticulous control of glucose metabolism could effectively prevent diabetic angiopathy ... Bloodworth JM Jr: Diabetic retinopathy. Diabetes 1962; 11: 1-22. Engerman R, Bloodworth JM Jr, Nelson S: Relationship of ... Bloodworth JM Jr, Engerman RL, Anderson PJ: Microangiopathy in the experimentally-diabetic animal. Adv Metab Disord 1973; 2 ( ... In particular, his studies of diabetic retinopathy, in collaboration with ophthalmological colleagues at UWMS, defined the ...
Diabetic nephropathy is a progressive kidney disease caused by angiopathy of the capillaries in the glomeruli. It is ... which lead to diabetic nephropathy and hypertensive nephropathy, respectively. One cause of nephropathy is the long term usage ... "Dietary acid load and rapid progression to end-stage renal disease of diabetic nephropathy in Westernized South Asian people". ...
Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc. Natl. Acad. Sci. ... 心血管疾病、非酮症之超滲透壓的昏迷(英语:nonketotic hyperosmolar coma)、糖尿病酮症酸中毒、中風、慢性肾脏病、
... diabetic angiopathies MeSH C19.246.099.500.191 - diabetic foot MeSH C19.246.099.500.382 - diabetic retinopathy MeSH C19.246. ... diabetic nephropathies MeSH C19.246.099.937 - diabetic neuropathies MeSH C19.246.099.937.250 - diabetic foot MeSH C19.246. ... 099.750 - diabetic coma MeSH C19.246.099.750.490 - hyperglycemic hyperosmolar nonketotic coma MeSH C19.246.099.812 - diabetic ...
... and lumbar syndromes Arthrosis of the large joints Obliterating atherosclerosis of the extremity vessels Diabetic angiopathy ...
... insulin dependent Diabetic angiopathy Diabetic embryopathy Diabetic nephropathy Diabetic neuropathy Diamond-Blackfan anemia ...
... diabetic angiopathy). Around half of the patients with a diabetic foot ulcer have co-existing PAD. Vitamin D deficiency has ... A critical evaluation of existing diabetic foot screening guidelines. The review of diabetic studies: RDS, 13(2-3), p.158. ... Presence of several characteristic diabetic foot pathologies such as infection, diabetic foot ulcer and neuropathic ... A diabetic foot is any pathology that results directly from peripheral arterial disease (PAD) and/or sensory neuropathy ...
It is also possible to classify angiopathy by the associated condition: Diabetic angiopathy Cerebral amyloid angiopathy " ... The best known and most prevalent angiopathy is diabetic angiopathy, a common complication of chronic diabetes. There are two ... Angiopathy is the generic term for a disease of the blood vessels (arteries, veins, and capillaries). ... so-called proliferative diabetic retinopathy). Damage to nerve cells may cause peripheral neuropathy, and to kidney cells, ...
... is a form of angiopathy associated with diabetic complications. While not exclusive, the two most common ... "Diabetic dermopathy" is a manifestation of diabetic angiopathy. It is often found on the shin. There is also neuropathy; also ... Prognosis is generally poor for all forms of diabetic angiopathy, as symptomatology is tied to the advancement of the ... In diabetic retinopathy the end-result is often blindness due to irreversible retinal damage. ...
... (DN), also known as diabetic kidney disease,[4] is the chronic loss of kidney function occurring in those ... in patients with diabetic mellitus has been shown to decrease the risk of progression of DN as well as other diabetic ... "diabetic nephropathy". Retrieved 2015-06-27.. *^ Schlöndorff D, Banas B (June 2009). "The mesangial cell revisited: no cell is ... "The Review of Diabetic Studies. 12 (1-2): 110-8. doi:10.1900/RDS.2015.12.110. PMC 5397986. PMID 26676664.. ...
Distal symmetrical polyneuropathy (DSPN), the diabetic type of which is also known as diabetic peripheral neuropathy (DPN) ( ... Diabetic neuropathy refers to various types of nerve damage associated with diabetes mellitus. Symptoms depend on the site of ... Heat, therapeutic ultrasound,[20] hot wax[20] are also useful for treating diabetic neuropathy.[20] Pelvic floor muscle ... "Diabetic Neuropathy". PubMed Health. 2010-04-19. Archived from the original on 2011-02-05. Retrieved 2011-05-03.. ...
... (diabetic kidney disease) (DN)[1] is the chronic loss of kidney function occurring in those with diabetes ... The incidence of diabetic nephropathy is higher in diabetics with one or more of the following conditions:[12] ... "Diabetic Nephropathy: Background, Pathophysiology, Etiology". 2015-06-20.. *^ a b Lewis G, Maxwell AP (2014). "Risk factor ... "diabetic nephropathy". Retrieved 2015-06-27.. *^ The Mesangial Cell Revisited: No Cell Is an Island. doi: 10.1681/ASN. ...
Diabetic angiopathy See: Angiopathy. Diabetic coma see coma Diabetic ketoacidosis (DKA) see acidosis Diabetic myelopathy Spinal ... Diabetic nephropathy See: Nephropathy Diabetic neuropathy See: Neuropathy Diabetic osteopathy Bone disease secondary to chronic ... For a diabetic, coma can be caused by hypoglycemia or by diabetic ketoacidosis. Comatose in a coma; not conscious. ... Women who become diabetic during their pregnancies have a 15% higher chance of developing preeclampsia; women who are diabetic ...
Also miR-192 levels have been shown to be increased in glomeruli isolated from diabetic mice when compared to non-diabetic mice ... Nephropathy is another common symptom of diabetes patients and is caused by angiopathy of the capillaries in the kidneys. A ... Metabolic memory is the phenomenon of diabetic vascular stresses persisting after glucose normalization in diabetic patients ... Being in this state of diabetic stress leads to long term metabolic memory and altered epigenome with adverse side effects on ...
Main article: Diabetic nephropathy. Diabetic nephropathy is a progressive kidney disease caused by angiopathy of the ... "Dietary acid load and rapid progression to end-stage renal disease of diabetic nephropathy in Westernized South Asian people". ... which lead to diabetic nephropathy and hypertensive nephropathy, respectively. ...
... that non-diabetic first-degree relatives of diabetics had elevated enzyme levels associated with diabetic renal disease and ... Chronic elevation of blood glucose level leads to damage of blood vessels called angiopathy. The endothelial cells lining the ... It is why it takes longer for diabetics to heal from leg and foot wounds and why diabetics are prone to leg and foot infections ... Diabetic amyotrophy is muscle weakness due to neuropathy. Diabetic retinopathy, growth of friable and poor-quality new blood ...
... cerebral amyloid angiopathy, familial MeSH C18.452.090.100 - cerebral amyloid angiopathy MeSH C18.452.090.100.160 - cerebral ... diabetic ketoacidosis MeSH C18.452.076.176.652 - ketosis MeSH C18.452.076.354 - alkalosis MeSH C18.452.076.354.271 - alkalosis ... diabetic ketoacidosis MeSH C18.452.394.750.774 - prediabetic state MeSH C18.452.394.937 - glycosuria MeSH C18.452.394.937.450 ... cerebral amyloid angiopathy, familial MeSH C18.452.648.151 - brain diseases, metabolic, inborn MeSH C18.452.648.151.050 - ...
It is recommended that diabetics visit an eye doctor once a year.[30] Damage to the kidneys, known as diabetic nephropathy, can ... Diabetic ketoacidosis, nonketotic hyperosmolar coma, heart disease, stroke, chronic kidney failure, foot ulcers[3][2]. ... Diabetic emergencies. Low blood sugar (hypoglycemia), is common in persons with type 1 and type 2 DM. Most cases are mild and ... See also: Diabetic diet. People with diabetes can benefit from education about the disease and treatment, good nutrition to ...
the 2008 observation, that non-diabetic first-degree relatives of diabetics had elevated enzyme levels associated with diabetic ... Chronic elevation of blood glucose level leads to damage of blood vessels called angiopathy. The endothelial cells lining the ... Diabetic amyotrophy is muscle weakness due to neuropathy.. *Diabetic retinopathy, growth of friable and poor-quality new blood ... When combined with damaged blood vessels this can lead to diabetic foot (see below). Other forms of diabetic neuropathy may ...
The efficacy of calcium dobesilate has been described e.g. in patients with diabetic retinopathy or diabetic nephropathy. " ... Microangiopathy (or microvascular disease, or small vessel disease) is an angiopathy (i.e. disease of blood vessels) affecting ... diabetic retinopathy) or kidney (diabetic nephropathy). Nerves and neurons, if not sufficiently supplied with blood, are also ... Laser therapy of diabetic retinopathy. A number of medicines, such as calcium dobesilate, are being marketed for the specific ...
In diabetic patients, the amine oxidase activity stimulates glucose uptake via translocation of transporters to the cell ... aggregation along with oxidative stress and thus are considered a potential risk factor for stress-related angiopathy. In these ... This mimics insulin and interferes with cell processes in diabetic patients. Additionally, hydrogen peroxide, along with ... diabetic patients have a greater chance of developing oncogenesis and tumor progression. In one study, serum VAP-1 was shown to ...
... diabetic foot MeSH C14.907.320.382 - diabetic retinopathy MeSH C14.907.355.350 - embolism MeSH C14.907.355.350.254 - embolism, ... cerebral amyloid angiopathy MeSH C14.907.253.560.200.200.160 - cerebral amyloid angiopathy, familial MeSH C14.907.253.560. ...
... irritation or distortion of cranial nerves or upper cervical roots by structural lesions Optic neuritis Ocular diabetic ... Headache attributed to benign angiopathy of the central nervous system Headache attributed to pituitary apoplexy Headache ...
Levy E, Jaskolski M, Grubb A (January 2006). "The role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology ... including diabetic patients, in chronic kidney disease (CKD), and after kidney transplant. The UK's National Institute for ... "Entrez Gene: CST3 cystatin C (amyloid angiopathy and cerebral hemorrhage)". Hwang SJ, Yang Q, Meigs JB, Pearce EN, Fox CS ( ... Mutations in the cystatin 3 gene are responsible for the Icelandic type of hereditary cerebral amyloid angiopathy, a condition ...
"Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients". Proc Natl Acad Sci ... "Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients". Proc. Natl. Acad. ... ACys+ABri/Cerebral amyloid angiopathy. *Aβ/Alzheimer's disease. Kidney. *AApoA1+AFib+ALys/Familial renal ... of islet amyloid peptide in lipofuscin bodies and secretory granules of human B-cells and in islets of type-2 diabetic subjects ...
... in rate of albumin excretion and albumin to creatinine ratios in overnight and daytime urine collections in non-diabetic ...
Grossman E, Messerli FH (August 1996). "Diabetic and hypertensive heart disease". Annals of Internal Medicine. 125 (4): 304-310 ...
Hyperosmolar hyperglycemic state, diabetic ketoacidosis, heart disease, strokes, diabetic retinopathy, kidney failure, ... A proper diet and exercise are the foundations of diabetic care,[23] with a greater amount of exercise yielding better results. ... "Antihypertensive agents for preventing diabetic kidney disease". Cochrane Database of Systematic Reviews. 12: CD004136. doi: ... There are several classes of anti-diabetic medications available. Metformin is generally recommended as a first line treatment ...
... cerebral amyloid angiopathy MeSH C10.228.140.300.510.200.200.160 - cerebral amyloid angiopathy, familial MeSH C10.228.140.300. ... diabetic neuropathies MeSH C10.668.829.350 - guillain-barre syndrome MeSH C10.668.829.350.500 - miller fisher syndrome MeSH ... cerebral amyloid angiopathy, familial MeSH C10.228.140.163.100.175 - citrullinemia MeSH C10.228.140.163.100.320 - galactosemias ...
Fundoscopic view of a patient with diabetic retinopathy. Similar to hypertensive retinopathy, evidence of nerve fiber infarcts ...
See also: Anti-diabetic medication. There are several classes of anti-diabetic medications available. Metformin is generally ... Hyperosmolar hyperglycemic state, diabetic ketoacidosis, heart disease, strokes, diabetic retinopathy, kidney failure, ... A diabetic diet which includes calorie restriction to promote weight loss is generally recommended.[95][58] Other ... A proper diet and exercise are the foundations of diabetic care,[23] with a greater amount of exercise yielding better results. ...
This test measures the changes in body weight, urine output, and urine composition when fluids are withheld to induce dehydration. The body's normal response to dehydration is to conserve water by concentrating the urine. Those with DI continue to urinate large amounts of dilute urine in spite of water deprivation. In primary polydipsia, the urine osmolality should increase and stabilize at above 280 Osm/kg with fluid restriction, while a stabilization at a lower level indicates diabetes insipidus.[10] Stabilization in this test means, more specifically, when the increase in urine osmolality is less than 30 Osm/kg per hour for at least three hours.[10] Sometimes measuring blood levels of ADH toward the end of this test is also necessary, but is more time consuming to perform.[10] To distinguish between the main forms, desmopressin stimulation is also used; desmopressin can be taken by injection, a nasal spray, or a tablet. While taking desmopressin, a patient should drink fluids or water only ...
Diabetic comas:. •Diabetic hypoglycemia. •Diabetic ketoacidosis. •Nonketotic hyperosmolar Diabetic myonecrosis. Diabetic ... Diabetes mellitus (type 1, type 2, coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy) - Hypoglycemia - ... Diabetic dieta. •Panulung panlaban-diabetes. •Pangkaraniwan pamanulunginsulin. •Masasag a pamanulunginsulin Aliwang ... ding Tinduk 1 a diabetic dagul lang Tinduk 1 diabetic a pang atin idad. ...
Many type 1 diabetics are diagnosed when they present with diabetic ketoacidosis. The signs and symptoms of diabetic ... The reason is bladder dysfunction that is more common in diabetics than in non-diabetics due to diabetic nephropathy. When ... Untreated type 1 diabetes can commonly lead to diabetic ketoacidosis which is a diabetic coma which can be fatal if untreated.[ ... Complications of poorly managed type 1 diabetes mellitus may include cardiovascular disease, diabetic neuropathy, and diabetic ...
... diabetic peripheral neuropathy); or atypical infections such as nocardiosis, sporotrichosis, or mycobacterial infections. ...
In endocrinology, medical emergencies include diabetic ketoacidosis, hyperosmolar hyperglycemic state, hypoglycemic coma, acute ...
Diabetic angiopathy is a form of angiopathy associated with diabetic complications. While not exclusive, the two most common ... "Diabetic dermopathy" is a manifestation of diabetic angiopathy. It is often found on the shin. There is also neuropathy; also ... Prognosis is generally poor for all forms of diabetic angiopathy, as symptomatology is tied to the advancement of the ... In diabetic retinopathy the end-result is often blindness due to irreversible retinal damage. ...
"Diabetic Angiopathies" by people in this website by year, and whether "Diabetic Angiopathies" was a major or minor topic of ... "Diabetic Angiopathies" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Diabetic Angiopathies" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Diabetic Angiopathies". ...
MalaCards integrated aliases for Diabetic Peripheral Angiopathy:. Name: Diabetic Peripheral Angiopathy 12 15 71 ... Comorbidity relations with Diabetic Peripheral Angiopathy via Phenotypic Disease Network (PDN): Acute Cystitis Heart Disease ... Pathways related to Diabetic Peripheral Angiopathy according to GeneCards Suite gene sharing:. #. Super pathways. Score. Top ... MalaCards based summary : Diabetic Peripheral Angiopathy is related to heterophyiasis and toxicodendron dermatitis. An ...
Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy. In: Diabetes Research and Clinical ... Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy. Diabetes Research and Clinical ... Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy. / Cui, Xinglong; Kushiyama, ... title = "Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy", ...
Diabetic Vascular Complications; Diabetic Vascular Diseases; Microangiopathy, Diabetic. On-line free medical diagnosis ... Diabetic Angiopathies (Diabetic Vascular Complications; Diabetic Vascular Diseases; Microangiopathy, Diabetic). vascular ... Ranked list of diseases related to "Diabetic Angiopathies"Drugs, active principles and "Diabetic Angiopathies"Medicinal plants ... Diabetic foot ulcerDiabetic retinopathyDiabetic retinopathy - Simple English Wikipedia, the free encyclopedia ...
What is diabetic angiopathy? Meaning of diabetic angiopathy medical term. What does diabetic angiopathy mean? ... Looking for online definition of diabetic angiopathy in the Medical Dictionary? diabetic angiopathy explanation free. ... Related to diabetic angiopathy: diabetic macroangiopathy. diabetic angiopathy. Vascular disease in Pts with long-term DM. See ... Diabetic angiopathy results from accelerated atherosclerosis, produces thickening of basement membrane.. Management of diabetic ...
SMOKING AS A TRIGGER FACTOR IN THE DEVELOPMENT OF DIABETIC ANGIOPATHY OF LOWER EXTREMITIES IN MEN WITH ... SMOKING AS A TRIGGER FACTOR IN THE DEVELOPMENT OF DIABETIC ANGIOPATHY OF LOWER EXTREMITIES IN MEN WITH ... gene polymorphism and the development of diabetic angiopathy of lower extremities (DALE) in ethnic Russian men residing in ...
Oth diabetes w diabetic peripheral angiopathy w/o gangrene Long Description: Other specified diabetes mellitus with diabetic ... 443.81 - Angiopathy in other dis (combination) Combination Flag. The combination flag indicates that more than one code in the ... Also called: Diabetic complications. If you have diabetes, your blood glucose, or blood sugar, levels are too high. Over time, ... peripheral angiopathy without gangrene This is the 2018 version of the ICD-10-CM diagnosis code E13.51. Valid for Submission ...
Diabetic Angiopathies. Leg Ulcer. Skin Ulcer. Diabetes Complications. Diabetes Mellitus. Diabetic Neuropathies. ... Study of Subjects With Diabetic Foot Ulcer (DFU). The safety and scientific validity of this study is the responsibility of the ... Diabetic Foot. Foot Ulcer. Vascular Diseases. Cardiovascular Diseases. Skin Diseases. Endocrine System Diseases. Foot Diseases ... Currently receiving treatment for a diagnosis of diabetic foot ulcer or have had an active foot ulcer healed within the last 6 ...
Diabetic Foot. Diabetic Angiopathies. Vascular Diseases. Cardiovascular Diseases. Foot Ulcer. Leg Ulcer. Skin Ulcer. Skin ... Infection; Diabetic Foot Drug: Ertapenem sodium Drug: Piperacillin/tazobactam sodium Drug: Piperacillin/tazobactam-matching ... MedlinePlus related topics: Diabetic Foot Foot Health Potassium Drug Information available for: Piperacillin sodium ... Diabetic Neuropathies. Amoxicillin. Tazobactam. Penicillanic Acid. Piperacillin. Ertapenem. Piperacillin, tazobactam drug ...
Diabetic Angiopathies. Vascular Diseases. Cardiovascular Diseases. Diabetes Complications. Antihypertensive Agents. Angiotensin ... DIRECT: DIabetic Retinopathy Candesartan Trials. Effects of Candesartan Cilexetil (Candesartan) on Diabetic Retinopathy in Type ... DIabetic Retinopathy Candesartan Trials. (DIRECT). The safety and scientific validity of this study is the responsibility of ... Regression of diabetic retinopathy was defined as at least a 3 step improvement or a persistent 2-step improvement (confirmed ...
Diabetic Retinopathy. Vision, Low. Retinal Degeneration. Eye Diseases. Diabetic Angiopathies. Vascular Diseases. Cardiovascular ... Diabetic Macular Edema. Diabetic Retinopathy. Macular Edema. Photocoagulation. Psychophysical Testing. Stiles-Crawford Effect. ... The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at ... The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at ...
Diabetic Angiopathies / ethnology * Diabetic Angiopathies / etiology* * Female * Follow-Up Studies * Glycated Hemoglobin A / ...
Diabetic Angiopathies / pathology * Diabetic Angiopathies / prevention & control* * Humans * Hypoglycemic Agents / adverse ...
Diabetic Angiopathy K. Lundbaek. Pages 649-658 * The Eye in Diabetes mellitus ...
E10.52 Type 1 diabetes mellitus with diabetic peripheral angiopathy with gangrene E10.59 Type 1 diabetes mellitus with other ... Type 1 diabetes mellitus with diabetic peripheral angiopathy with gangrene. 2016 2017 2018 2019 Billable/Specific Code *E10.52 ... Short description: Type 1 diabetes w diabetic peripheral angiopathy w gangrene. *The 2019 edition of ICD-10-CM E10.52 became ... Type 1 diabetes mellitus with diabetic peripheral angiopathy without gangrene. 2016 2017 2018 2019 Billable/Specific Code ...
This study will compare the effects of olmesartan medoxomil and amlodipine on beta-cell function and the incidence diabetic ... Effect of olmesartan on beta-cell function and diabetic angiopathy in type 2 diabeteic patients with hypertension Next Previous ... Effect of olmesartan on beta-cell function and diabetic angiopathy in type 2 diabeteic patients with hypertension Recruiting ...
154 patients with diabetic angiopathy of lower extremities and obstructive injure of different arterial segments were observed ... study is analysis of the influence of antioxidant therapy for transdermal effort of oxygen in patients with diabetic angiopathy ...
Growth Hormone and Diabetic Angiopathy. Comparative Metabolic and Clinical Studies of Sexual Ateliotic Dwarfs and Diabetics. ... Plasma Levels of Growth Hormone and Glucagon in Diabetic Patients and Relatives of Diabetic Patients. Discussion. Plasma ... The Capillaries of South African Diabetics in Perspective. Diabetic Microangiopathy: Electron Microscope Findings in Human ... and the plasma levels of growth hormone and glucagon in diabetic patients and relatives of diabetic patients are also ...
In Diabetic Angiopathy. Tooke JE, Ed. London, Edward Arnold, 2000, p. 45-63. ... We found that calcium scores were significantly greater in diabetic than in nondiabetic subjects (P , 0.0001), with diabetic ... and for the diabetic subjects was the subgroup of diabetic subjects in the calcium score first tertile. ... However, in diabetic subjects, there was no significant relation observed between baseline CT calcium scores and the subsequent ...
Diabetic Angiopathies / physiopathology. Graft Occlusion, Vascular / pathology, physiopathology*. Humans. Hyperlipidemias / ...
Diabetic Angiopathies / diagnosis*. Exercise Test. Heart Rate. Humans. Impotence, Vasculogenic / physiopathology*. Israel. Male ... RESULTS: Included were 18 diabetic men with ED (SHIM questionnaire scores 5-21) and 18 diabetic men without ED (SHIM ... The medical charts of diabetic men with vascular ED from a single-sex clinic were reviewed, as well as the medical charts of ... CONCLUSIONS: Erectile dysfunction severity might be associated with poor cardiovascular prognosis in adult diabetic men with no ...
Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetes Complications Research ... Severe hypoglycemia and diabetic ketoacidosis among youth with type 1 diabetes in the T1D Exchange clinic registry. Pediatr ...
Diabetic Angiopathy Inapp elevation of blood glucose levels and accelerated artherosclerosis > could lead to ulcers, amps, ...
Diseases associated with AOC3 include Diabetic Angiopathy and Immunodeficiency 17. Among its related pathways are Phenylalanine ...
Categories: Diabetic Angiopathies Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
diabetic angiopathy ISO. RGD:735849. 7240710. OMIM. Diamond-Blackfan Anemia-Like ISO. RGD:735849. 7240710. OMIM. ... diabetic retinopathy ISO. RGD:735849. 9068941. DNA:snp:promoter:-1125T>Grs1617640human. RGD. PMID:18458324, REF_RGD_ID:2313838 ... Diabetic Nephropathies ISO. RGD:735849. 9068941. DNA:snp:promoter:-1125T>Grs1617640human. RGD. PMID:18458324, REF_RGD_ID: ... Diabetic Nephropathies ISO. RGD:735849. 9068941. Protein:decreased expression:serum. RGD. PMID:19619913, REF_RGD_ID:2313832. ...
Pirart J, Barbier P: Protective effects of hemochromatosis against senile and diabetic angiopathies. Diabetologia 7: 227-236, ... Nankivell BJ, Tay YC, Boadle RA, Harris DC: Lysosomal iron accumulation in diabetic nephropathy. Ren Fail 16:367-381, 1994. ... The characteristics of the 1,245 type 2 diabetic patients with complete HFE genotype data (96.2% of the total type 2 diabetes ... However, without a diabetic nonhemochromatotic group, this can be interpreted as showing diabetes-associated reduced life ...
Diabetic Angiopathies (Diabetic Angiopathy) 05/01/2000 - "Cross-link breakers seem to be effective in preventing or reversing ... 07/01/2009 - "Many studies have demonstrated association between advanced glycation end products (AGEs) and diabetic angiopathy ... Diabetic Nephropathies (Diabetic Nephropathy) 01/01/2014 - "In our study, we hypothesized that receptors for advanced glycation ... 01/01/2015 - "Advanced glycation end-products (AGEs) are thought to play a major role in the pathogenesis of diabetic vascular ...
208000004205 Diabetic Angiopathies Diseases 0.000 description 1 * 208000007342 Diabetic Nephropathies Diseases 0.000 ... 208000001636 Diabetic Neuropathies Diseases 0.000 description 1 * 206010061835 Diabetic nephropathy Diseases 0.000 description ... 206010012680 Diabetic neuropathy Diseases 0.000 description 1 * JZUFKLXOESDKRF-UHFFFAOYSA-N Dichlothiazide Chemical compound ...
  • While not exclusive, the two most common forms are diabetic retinopathy and diabetic nephropathy, whose pathophysiologies are largely identical. (wikipedia.org)
  • The glomeruli of the kidneys are especially sensitive - see diabetic nephropathy - where protein leakage caused by late-stage angiopathy results in diagnostic proteinuria and eventually kidney failure. (wikipedia.org)
  • These MMI values reflected intracellular lipids, including cholesteryl ester assayed by GC/MS. Statistical analysis revealed MMI to correlate positively and independently with serum triglycerides, the state of diabetic retinopathy, nephropathy and obesity, but negatively with administration of α-glucosidase inhibitors or thiazolidinediones. (elsevier.com)
  • H63D and C282Y have been reported to be independent risk factors for diabetic nephropathy ( 10 ) and proliferative retinopathy ( 11 ), respectively. (diabetesjournals.org)
  • In proportion to the rapid increase of diabetic population, diabetic nephropathy is now a major cause of end-stage renal disease and diabetic retinopathy is a leading cause of blindness [ 3 ]. (hindawi.com)
  • In diabetes, endothelial nitric oxide synthase (eNOS) produces superoxide anion rather than nitric oxide, referred to as "eNOS uncoupling," which may contribute to endothelial dysfunction, albuminuria, and diabetic nephropathy. (asnjournals.org)
  • Taken together, these data suggest that maintenance of endothelial GTPCH I expression and the resulting improvement in BH4 biosynthesis ameliorate diabetic nephropathy. (asnjournals.org)
  • 1 , 2 Diabetic vascular complications including diabetic nephropathy represent the leading cause of morbidity and mortality in affected patients. (asnjournals.org)
  • 14 , 15 We previously reported that the imbalance between NO and ROS contributes to albuminuria in diabetic nephropathy, whereas administration of BH4 ameliorates glomerular NO/ROS balance. (asnjournals.org)
  • However, no studies have been performed to examine the effectiveness of BH4 in diabetic nephropathy. (asnjournals.org)
  • Thus diabetic nephropathy may at least in part be due to insulin deficiency rather than hyperglycemia. (the-aps.org)
  • Clinical studies have found association between reduced ADAMTS13-specific activity, ultralarge VWF multimers, and thrombotic angiopathy in patients with diabetic nephropathy. (ahajournals.org)
  • It remains unknown, however, whether ADAMTS13 deficiency or ultralarge VWF multimers have a causative effect in diabetic nephropathy. (ahajournals.org)
  • Approach and Results- The extent of renal injury was evaluated in wild-type (WT), Adamts 13 −/− and Adamts 13 −/− Vwf −/− mice after 26 weeks of streptozotocin-induced diabetic nephropathy. (ahajournals.org)
  • Genetic deletion of VWF in Adamts 13 −/− diabetic mice improved kidney function, inhibited intrarenal thrombosis, and alleviated histological changes in glomeruli, suggesting that exacerbation of diabetic nephropathy in the setting of ADAMTS13 deficiency is VWF dependent. (ahajournals.org)
  • Conclusions- ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF-dependent intrarenal thrombosis. (ahajournals.org)
  • The levels of advanced glycation end products in the vitreous correlate with the progression of diabetic retinopathy. (aspetjournals.org)
  • Vitamin B6 has been shown to reduce the production of advanced glycation end products (AGEs) in diabetic lenses. (lifeextension.com)
  • Damage to nerve cells may cause peripheral neuropathy, and to kidney cells, diabetic kidney disease (Kimmelstiel-Wilson syndrome). (wikipedia.org)
  • 52, 85 Better evidence suggests benefit with acetyl-L-carnitine for a major complication of diabetes, diabetic peripheral neuropathy (injury to nerves of the extremities caused by diabetes). (lifescript.com)
  • 83 Acetyl-L-carnitine might help prevent diabetic cardiac autonomic neuropathy (injury to the nerves of the heart caused by diabetes). (lifescript.com)
  • The purpose was to clarify the external force associated with callus formation in patients with diabetic neuropathy. (hindawi.com)
  • approximately half of patients with diabetes have symptoms of diabetic neuropathy [ 1 ]. (hindawi.com)
  • Nearly a quarter of diabetics suffer from diabetic peripheral neuropathy now and up to 50% of all diabetics develop peripheral neuropathy after 25 years of having their disease. (practicalpainmanagement.com)
  • Therefore, there is an emphasis on good glucose control for the prevention of pain and the progression of diabetic peripheral neuropathy. (practicalpainmanagement.com)
  • Clinical diabetes was present in six of the 14 patients with neuropathy but there was no relation in the non-diabetic patients between neuropathy and minor impairment of carbohydrate tolerance. (bmj.com)
  • Then diabetic ketoacidosis, angiopathy, and neuropathy were examined as diabetic complications for their involvement in cognitive impairments. (iospress.com)
  • Foot infection in diabetics develops because of coexisting angiopathy, immunopathy, and neuropathy. (diabetesindia.com)
  • These include neuropathy, angiopathy and immunopathy. (news-medical.net)
  • Example: Codes E11.51 and Z79.4 are used for a Type II diabetes mellitus patient with diabetic peripheral angiopathy without gangrene who has used insulin for many years. (aapc.com)
  • See Diabetic macroangiopathy , Diabetic microangiopathy . (thefreedictionary.com)
  • This project aims at analysing the role of oxidative protein modifications as a potential protective mechanism of vascular cells against late diabetic lesions, and diabetic macroangiopathy in particular. (uni-heidelberg.de)
  • There are two types of angiopathy: macroangiopathy and microangiopathy. (wikipedia.org)
  • Macroangiopathy may cause other complications, such as ischemic heart disease, stroke and peripheral vascular disease which contributes to the diabetic foot ulcers and the risk of amputation. (wikipedia.org)
  • Diabetic angiopathy including micro- and macroangiopathy is concerned with high rate of morbidity and mortality in patients with long-standing diabetes. (hindawi.com)
  • It proves that reactive oxygen species produced in mitochondria play an important role in pathogenesis of diabetic wounds. (news-medical.net)
  • Type I diabetics are patients dependent upon exogenous insulin to prevent ketoacidosis. (google.com)
  • Acute Pancreatitis can be a precipitation factor for diabetic ketoacidosis (DKA). (brightkite.com)
  • Thus, tissues which are very sensitive to oxygen levels, such as the retina, develop microangiopathy and may cause blindness (so-called proliferative diabetic retinopathy). (wikipedia.org)
  • Aortic smooth muscle cells (SMCs) of diabetic animals have unique properties, including the overexpression of transforming growth factor-β (TGF-β) type II receptor, fibronectin, and platelet-derived growth factor β-receptor. (diabetesjournals.org)
  • We have previously reported that cultured aortic smooth muscle cells (SMCs) and medial layers of arteries of diabetic rats and rabbits express more platelet-derived growth factor (PDGF) β-receptor, transforming growth factor-β (TGF-β) type II receptor, and fibronectin than those of nondiabetic animals ( 1 - 3 ). (diabetesjournals.org)
  • In this study, serum samples from Type 2 diabetic patients were added to the medium with J774.1 cells and the degree of foam cell induction was quantified by measuring lipid accumulation. (elsevier.com)
  • The primary objective for all three pooled studies is to determine whether candesartan , compared to placebo, reduces the incidence of microalbuminuria in type 1 and type 2 diabetic patients. (clinicaltrials.gov)
  • RESEARCH DESIGN AND METHODS - HFE genotype data were available for 1,245 type 2 diabetic patients from the longitudinal observational Fremantle Diabetes Study (FDS), representing 96.2% of the total FDS type 2 diabetes cohort. (diabetesjournals.org)
  • In 328 type 2 diabetic patients followed for 9.0 years (mean), we investigated whether endothelial dysfunction and chronic inflammation (estimated from plasma markers) can explain the association between (micro)albuminuria and mortality. (diabetesjournals.org)
  • Microalbuminuria in type 1 and type 2 diabetic patients, as well as in nondiabetic individuals, is associated with endothelial dysfunction and low-grade inflammation ( 6 - 13 ). (diabetesjournals.org)
  • Such studies are essential before directed screening for iron overload can be recommended in diabetic patients ( 12 ). (diabetesjournals.org)
  • Number of Participants With a 3-step or Greater Increase in Early Treatment of Diabetic Retinopathy Study (EDTRS) Severity Scale [ Time Frame: From baseline to end of study, i.e. 5 years, with visits after a half year, one year and thereafter one visit per year. (clinicaltrials.gov)
  • Regression of diabetic retinopathy was defined as at least a 3 step improvement or a persistent 2-step improvement (confirmed in 2 consecutive photography sets) in the Early Treatment of Diabetic Retinopathy Study (ETDRS) severity scale. (clinicaltrials.gov)
  • The thromboxane-synthesis inhibitor Ibustrin in the treatment of diabetic angiopathies]. (semanticscholar.org)
  • A review of the diagnosis, evaluation, and treatment of diabetic peripheral neuropathic pain. (practicalpainmanagement.com)
  • The primary objective is to determine whether candesartan , compared to placebo reduces the progression of diabetic retinopathy in normotensive, normoalbuminuric type 1 diabetic patients with retinopathy. (clinicaltrials.gov)
  • C-reactive protein (CRP) is an inflammatory biomarker that may be associated with diabetic retinopathy (DR), but body mass index (BMI) is an important confounder of this relationship. (arvojournals.org)
  • However, simply blocking the RAGE receptor was not effective in reducing the complications associated with diabetic retinopathy ( Peyroux and Sternberg, 2006 ). (aspetjournals.org)
  • Findings by us and others demonstrate that increased flux via AR in diabetics perpetuates increased injury after myocardial infarction, accelerates atherosclerotic lesion formation, and promotes restenosis via multiple mechanisms. (springer.com)
  • Using gene array studies, we examined CD34(+) cells isolated from a cohort of longstanding diabetic individuals, free of microvascular complications despite suboptimal glycemic control, and found that the cells exhibited reduced transcripts of both TGF-β1 and PAI-1 compared to age, sex, and degree of glycemic control-matched diabetic individuals with microvascular complications. (nih.gov)
  • CD34(+) cells from diabetic subjects with microvascular complications consistently exhibited higher PAI-1 mRNA than age-matched non-diabetic controls. (nih.gov)
  • Diabetic individuals protected from development of microvascular complications exhibit reduced expression of PAI-1 and increased expression of uPA in CD34+ cells.Microarrays were conducted on CD34+ cells obtained from diabetic individuals with microvascular complications (n=5), diabetic individuals without microvascular complications (n=5), healthy age-matched controls (n=4). (nih.gov)
  • We hypothesized that diabetic individuals protected from the development of microvascular complications might have more robust CD34+ cell function with a superior reparative response compared to CD34+ cells from diabetic individuals manifesting vascular complications. (nih.gov)
  • We identified a unique diabetic cohort without microvascular complications despite having diabetes for more than 40 years with largely poor metabolic control throughout this entire time. (nih.gov)
  • CD34+ cells from this cohort of protected subjects showed increased migratory potential compared to cells from diabetic subjects with microvascular complications [30]. (nih.gov)
  • Using gene array studies, we compared the CD34+ cells from protected diabetic individuals to diabetic individuals with microvascular complications that were matched for sex, age and glucose control, as well as to healthy controls using Affymetrix microarrays (Table 1). (nih.gov)
  • Accelerated degradation of guanosine triphosphate cyclohydrolase I (GTPCH I), the rate-limiting enzyme in BH4 biosynthesis, also occurs in diabetes, suggesting that GTPCH I may have a role in diabetic microvascular disease. (asnjournals.org)
  • Angiopathy begins at the microvascular level, with thickening of the basement membrane and reduced blood flow. (diabetesindia.com)
  • Vascular diseases, such as diabetic angiopathies, thoracic outlet syndrome and arterial occlusive disease, are also classified as cardiovascular diseases. (reference.com)
  • The most prevalent eye diseases in individuals over 40 years old are age-related macular degeneration, glaucoma, diabetic eye disease and cataracts, as reported by WebMD. (reference.com)
  • A study of the clinical observations and the neuropathological findings in the brain of 16 juvenile diabetics dying of diabetic angiopathy after many years of diabetes is presented. (springer.com)
  • Insulin or oral glucose increased temporarily albumin excretion in normal subjects, but oral glucose had no effect in juvenile diabetics. (the-aps.org)
  • Effects of Candesartan Cilexetil ( Candesartan ) on Diabetic Retinopathy in Type 1 Diabetic Patients With Retinopathy. (clinicaltrials.gov)
  • Ophthalmologists should be encouraged to measure BP in their diabetic patients attending diabetic eye clinics, as it is an important risk factor for DR. On the basis of our findings, good BP control is a goal yet to be achieved in diabetic patients with retinopathy. (aston.ac.uk)
  • Diabetic retinopathy is a major complication of diabetes mellitus and a leading cause of visual impairment and blindness in the United States ( Aiello, 2003 ). (aspetjournals.org)
  • Prognosis is generally poor for all forms of diabetic angiopathy, as symptomatology is tied to the advancement of the underlying pathology i.e. the early-stage patient displays either non-specific symptoms or none at all. (wikipedia.org)
  • After 2-weeks of treatment clinical symptoms of diabetic angiopathy significantly improved in First group. (thefreedictionary.com)
  • Diabetic subjects experience a disproportionately large number of coronary heart disease events. (diabetesjournals.org)
  • This statement is given evidence by numerous experimental and clinical data which demonstrate efficacy in various indications, wuch as cerebrovascular insufficiency, senile organic brain syndrome, transient ischemic attacks, cerebral infarctus, ocular and otological circulatory disorders, peripheral angiopathies of arteriosclerotic, diabetic, or inflammatory origin with intermittent claudication, leg ulcers and other disturbances. (unboundmedicine.com)
  • Our data broadens the relevance of PGC-1α in the etiology of diabetic angiopathy, now with a potential to therapeutically restore EPCs vasculogenicity, and may provide an opportunity to improve the efficacy of autologous adoptive EPC therapy for limb and myocardial ischemia in DM. (ahajournals.org)
  • In other words, cumulative loss of lung function eventually worsens tissue hypoxia associated with angiopathy in distant organs and increases diabetic morbidity and mortality, they said. (medpagetoday.com)
  • This study investigated the association of vWf and CRP with cardiovascular and all-cause mortality among diabetic and nondiabetic subjects. (ahajournals.org)
  • Shrestha, T. , Aacharya, R. , Shrestha, R. and KC, M. (2017) Foot Care Knowledge and Practice among Diabetic Patients Attending General Outpatient Clinic in Tribhuvan University Teaching Hospital. (scirp.org)
  • There are limited studies done in Nepal on foot care among diabetic patients. (scirp.org)
  • The differentiation of macrophages into cytokine-secreting foam cells plays a critical role in the development of diabetic angiopathy. (elsevier.com)
  • The aim of this work was to elucidate the relationship between the functionally significant methylenetetrahydroxyfolatereductase (MTHFR) C677T (rs1801133) gene polymorphism and the development of diabetic angiopathy of lower extremities (DALE) in ethnic Russian men residing in Central Russia (mostly Kursk region). (cdc.gov)
  • Our results suggest that CTLA-4 may be involved in lipid metabolism and affect T2DM disease progression and/or the development of diabetic complications although this gene does not represent a major risk factor for T2DM. (medsci.org)
  • Diabetic dermopathy" is a manifestation of diabetic angiopathy. (wikipedia.org)
  • The first manifestation of diabetic retinopathy is. (brightkite.com)
  • In this paper, our current understanding about RAGE and its multiligand system will be reviewed remarkably in the development and progression of diabetic vascular complications and in possible therapeutic targets for these diseases. (hindawi.com)
  • Automatic detection of diabetic retinopathy turns out to be active research because of recent spread of this diseases largly. (brightkite.com)
  • Age, hypertension and glycemic control are well known risk factors and, in addition, high tissue plasminogen activator (tPA) activity turned out to be a novel early marker for asymptomatic LEAD in diabetic subjects, particularly in patients with type 2 diabetes. (diva-portal.org)
  • 0.05 versus WT diabetic mice), independent of hyperglycemia and hypertension. (ahajournals.org)
  • Conclusion - Attendance at the diabetic eye clinic is an important chance to detect both new patients with systemic hypertension and those with inadequate BP control. (aston.ac.uk)
  • ABSTRACT The effect of different antibiotics on the outcome of surgical care in the management of diabetic foot was investigated. (who.int)
  • This is a report of the relative risk (RR) for outcomes of coronary artery calcium in diabetic and nondiabetic subjects. (diabetesjournals.org)
  • RESEARCH DESIGN AND METHODS -A total of 1,312 diabetic and nondiabetic subjects underwent risk factor screening and computed tomography testing for coronary calcium at baseline and were followed clinically for 6.3 ± 1.4 years. (diabetesjournals.org)
  • Analyses in nondiabetic and diabetic subjects separately gave similar results. (ahajournals.org)
  • Increased levels of vWf are independently associated with cardiovascular and all-cause mortality in both diabetic and nondiabetic subjects. (ahajournals.org)
  • We performed a prospective population-based cohort study among nondiabetic and diabetic subjects to investigate the relation between vWf and CRP concentrations on one hand and cardiovascular and all-cause mortality on the other. (ahajournals.org)
  • In addition, SMC-dominant intimal thickening was enhanced in diabetic animals compared with nondiabetic animals at 2-4 weeks after balloon catheter injury (BCI) of the carotid arterial wall, by which PDGF is increased in the wall ( 3 , 4 ), suggesting that the changes in SMC properties by the overexpression of PDGF β-receptor play a critical role in arterial intimal thickening in diabetic animals. (diabetesjournals.org)
  • Although the diabetic retinopathy study (DRS), early treatment diabetic retinopathy study (ET DRS), diabetes control and complication trial (DC CT), and diabetic retinopathy clinical research network (DRCRnet) have greatly altered our approach to diabetic retinopathy, this systemic condition still poses a great challenge for all retinal specialists. (lww.com)
  • Rosano GM, Vitale C, Sposato B et al (2003) Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study. (springer.com)
  • The finding -- from the long-running Atherosclerosis Risk in Communities (ARIC) study -- implies that clinicians should pay attention to pulmonary function in diabetic patients, said Frederick Brancati, M.D., of Johns Hopkins and colleagues. (medpagetoday.com)
  • Results indicate it would be useful in central and peripheral vascular disease, including diabetic angiopathy. (healthy.net)
  • The best known and most prevalent angiopathy is diabetic angiopathy, a common complication of chronic diabetes. (wikipedia.org)
  • Type II diabetics are those with Non-Insulin-Dependent Diabetes Mellitus (NIDDM), and were previously designated as having maturity-onset, adult-onset, ketosis-resistant, or stable diabetes. (google.com)
  • Alteration in ADAMTS13-VWF balance may be one of the key pathophysiological mechanisms of thrombotic angiopathy in diabetes mellitus. (ahajournals.org)
  • The secondary objective is to determine whether candesartan , compared to placebo, reduces the incidence of clinically significant macular oedema (CSME) and/or proliferative diabetic retinopathy (PDR) and beneficially influences the rate of change in urinary albumin excretion rate (UAER). (clinicaltrials.gov)
  • Number of Participants With Incident Clinically Significant Macular Edema (CSME) and/or Proliferative Diabetic Retinopathy (PDR). (clinicaltrials.gov)
  • Clinically Significant Macular Edema (CSME) and Proliferative Diabetic Retinopathy (PDR) are diagnosed via retinal photographs. (clinicaltrials.gov)
  • Angiopathy is the generic term for a disease of the blood vessels (arteries, veins, and capillaries). (wikipedia.org)
  • Preventive and therapeutic strategies focusing on RAGE and its ligand axis may be of great importance in relieving diabetic vascular complications and reducing the burden of disease. (hindawi.com)
  • In short it is not at all wrong to say that stem cell therapy for diabetes has become a ray of hope and a new life for the diabetic patients to start living a life free of this disease. (amazonaws.com)
  • Blockade of AR-dependent signaling may hold the key to interrupting cycles of cellular perturbation and tissue damage in diabetic cardiovascular disease. (springer.com)
  • Diabetic angiopathy was not seen and axonal degeneration, which was never severe, was found in all disease groups equally. (bmj.com)
  • Age and hyperglycemia are the most important risk factors for development and progression of subclinical lower extremity arterial disease in type 2 diabetic subjects. (diva-portal.org)
  • Fungal nail infections accounts for up to half of all nail disease occurrences among diabetics. (news-medical.net)
  • A method for treating diabetes in a mammal by moderately controlling blood glucose concentration in the mammal together with administering to the mammal an amount of a tetracycline compound effective to reduce complications associated with diabetic hyperglycemia. (google.com)
  • Subjects were classified as diabetic if they had a history of being on a diet or medication for diabetes, had been diagnosed with diabetes during a hospital admission and were discharged on insulin or oral hypoglycemic medications at the termination of that hospital stay, or had a random plasma glucose of ≥11.1 mmol/l (200 mg/dl) at the time of recruitment. (diabetesjournals.org)
  • Diabetes was defined as random glucose ≥ 11.1 mmol/L, on diabetic medication or a history of physician-diagnosed diabetes. (arvojournals.org)
  • Uncontrolled diabetics are prone to infections due to numerous factors as the glucose-rich blood serves as an excellent media for growth. (pubmedcentralcanada.ca)
  • Blood glucose concentration can be controlled by moderate administration (e.g., fewer injections per day) of insulin or another glucose-modulating agent, while pathological complications characteristic of diabetic hyperglycemia are ameliorated through the activity of tetracycline compound, the latter preferably administered in an amount that is substantially non-antimicrobial. (google.com)
  • When the researchers stratified the diabetic patients according to fasting glucose levels, duration of diabetes, and use of diabetic medications at baseline, they found a graded inverse association between those characteristics and FVC and FEV 1 . (medpagetoday.com)
  • 3 , 4 The development of strategies to prevent or delay the progression of diabetic vascular complications requires a better understanding of the cellular and molecular mechanisms by which hyperglycemia exerts its adverse effects on the vascular system. (asnjournals.org)
  • Therefore, prevention of foot ulcers is of paramount importance and has long been recognized as a priority by the International Working Group on the Diabetic Foot [ 8 ]. (hindawi.com)
  • Other risk factors are associated with developing diabetic foot ulcers, one of which is said to be the external force on the plantar [ 8 ]. (hindawi.com)
  • This study compared ertapenem sodium to piperacillin/tazobactam sodium for the treatment of moderate to severe diabetic foot infections. (clinicaltrials.gov)
  • PGC-1α mediates the vasculogenic differentiation defect of circulating EPCs in T1 and T2 DM, in sharp contrast to the anti-migratory effect of EC PGC-1α in mediating diabetic angiostasis. (ahajournals.org)
  • Then the review focused on the cognitive complications of T1DM and their relation with the characteristics of T1DM, glycemic control, diabetic complications, comorbidities, and others. (iospress.com)