Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
The smallest divisions of the arteries located between the muscular arteries and the capillaries.
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Heteromultimers of Kir6 channels (the pore portion) and sulfonylurea receptor (the regulatory portion) which affect function of the HEART; PANCREATIC BETA CELLS; and KIDNEY COLLECTING DUCTS. KATP channel blockers include GLIBENCLAMIDE and mitiglinide whereas openers include CROMAKALIM and minoxidil sulfate.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Individuals responsible for various duties pertaining to the medical office routine.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
A subtype of endothelin receptor found predominantly in the KIDNEY. It may play a role in reducing systemic ENDOTHELIN levels.
Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells.
A subtype of endothelin receptor found predominantly in the VASCULAR SMOOTH MUSCLE. It has a high affinity for ENDOTHELIN-1 and ENDOTHELIN-2.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE.
Cholesterol present in food, especially in animal products.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.

Effects of glucagon and insulin on lipolysis and ketogenesis in sheep. (1/6530)

The hepatic and portal productions of acetoacetate and beta-hydroxybutyrate and lipolysis were studied in normal and insulin-controlled alloxan-diabetic sheep. Since hyperinsulinemia is associated with glucagon administration, the latter group of sheep were used to maintain constant plasma insulin levels. After control values were obtained glucagon was infused intraportally at 90 mug/hr for two hours. The ketone body production by portal drained viscera was not significantly affected by glucagon. In alloxanized sheep, glucagon significantly (P less than 0.01) increased net hepatic production of acetoacetate (from -0.54 +/- 0.08 to 0.46 +/- 0.07 g/hr). Lipolysis also increased. However, in the normal sheep, hyperinsulinemia prevented any stimulatory effect of glucagon on hepatic ketogenesis and lipolysis. Therefore, while glucagon appears capable of stimulating ketogenesis andlipolysis, these effects are readily suppressed by insulin.  (+info)

Effect of diabetes and aminoguanidine therapy on renal advanced glycation end-product binding. (2/6530)

BACKGROUND: Advanced glycation end-products (AGEs) have been implicated in the pathogenesis of diabetic nephropathy, and aminoguanidine (AG) has been shown to decrease the accumulation of AGEs in the diabetic kidney. METHODS: This study investigates changes in AGE binding associated with diabetes in the rat kidney using in vitro and in vivo autoradiographic techniques. Male Sprague-Dawley rats were randomized into control and diabetic groups with and without AG treatment and were sacrificed after three weeks. Frozen kidney sections (20 microm) were incubated with [125I]-AGE-RNase or [125I]-AGE-BSA. To localize the AGE binding site, in vivo autoradiography was performed by injection of 15 microCi of [125I]-AGE-BSA into the abdominal aorta of the rat. RESULTS: Low-affinity binding sites specific for AGEs in the renal cortex (IC50 = 0.28 microm) were detected by in vitro autoradiography. There was a significant increase in [125I]-AGE binding in the diabetic kidney, which was prevented by AG treatment. Emulsion autoradiography revealed that binding was localized primarily to proximal tubules in the renal cortex. Renal AGE levels, as assessed by fluorescence or by radioimmunoassay, were increased after three weeks of diabetes. This increase was attenuated by AG therapy. CONCLUSIONS: AGE binding sites are present within the proximal tubules of the kidney and appear to be modulated by endogenous AGE levels. It remains to be determined if these binding sites represent receptors involved in clearance of AGEs or are linked to pathogenic pathways that lead to the development of diabetic nephropathy.  (+info)

Treatment of streptozotocin-induced diabetic rats with vanadate and phlorizin prevents the over-expression of the liver insulin receptor gene. (3/6530)

Administration of vanadate, an insulinomimetic agent, has been shown to normalize the increased number of insulin receptors in the liver of streptozotocin-induced diabetic rats. In the present study, the effects of vanadate on various steps of expression of the liver insulin receptor gene in diabetic rats have been analyzed and compared with those of phlorizin, a glucopenic drug devoid of insulinomimetic properties. Livers of rats killed 23 days after streptozotocin injection showed a 30-40% increase in the number of cell surface and intracellular insulin receptors, a 50-90% increase in the levels of 9.5 and 7.5 kb insulin receptor mRNA species, and a 20% decrease in the relative abundance of the A (exon 11-) insulin receptor mRNA isotype. Daily administration of vanadate or phlorizin from day 5 to day 23 prevented the increase in insulin receptor number and mRNA level, and vanadate treatment also normalized receptor mRNA isotype expression. Unlike observations in vivo, vanadate and phlorizin differentially affected the expression of the insulin receptor gene in Fao hepatoma cells. Vanadate treatment (0.5 mmol/l for 4 h) decreased the levels of the 9.5 and 7.5 kb insulin receptor transcripts by at least twofold, without affecting the relative abundance of the A insulin receptor mRNA isotype. In contrast, phlorizin treatment (5 mmol/l for 4 h) slightly increased or did not affect the levels of the 9.5 and 7.5 kb insulin receptor transcripts respectively, and increased by twofold the relative expression of the A insulin receptor mRNA isotype. It is suggested that, although mediated in part by a reversal of hyperglycemia, normalization of liver insulin receptor gene expression by vanadate treatment in diabetic rats may also involve a direct inhibitory effect of this drug on gene expression.  (+info)

Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. (4/6530)

The peroxisome proliferator-activated receptors (PPARs) include three receptor subtypes encoded by separate genes: PPARalpha, PPARdelta, and PPARgamma. PPARgamma has been implicated as a mediator of adipocyte differentiation and the mechanism by which thiazolidinedione drugs exert in vivo insulin sensitization. Here we characterized novel, non-thiazolidinedione agonists for PPARgamma and PPARdelta that were identified by radioligand binding assays. In transient transactivation assays these ligands were agonists of the receptors to which they bind. Protease protection studies showed that ligand binding produced specific alterations in receptor conformation. Both PPARgamma and PPARdelta directly interacted with a nuclear receptor co-activator (CREB-binding protein) in an agonist-dependent manner. Only the PPARgamma agonists were able to promote differentiation of 3T3-L1 preadipocytes. In diabetic db/db mice all PPARgamma agonists were orally active insulin-sensitizing agents producing reductions of elevated plasma glucose and triglyceride concentrations. In contrast, selective in vivo activation of PPARdelta did not significantly affect these parameters. In vivo PPARalpha activation with WY-14653 resulted in reductions in elevated triglyceride levels with minimal effect on hyperglycemia. We conclude that: 1) synthetic non-thiazolidinediones can serve as ligands of PPARgamma and PPARdelta; 2) ligand-dependent activation of PPARdelta involves an apparent conformational change and association of the receptor ligand binding domain with CREB-binding protein; 3) PPARgamma activation (but not PPARdelta or PPARalpha activation) is sufficient to potentiate preadipocyte differentiation; 4) non-thiazolidinedione PPARgamma agonists improve hyperglycemia and hypertriglyceridemia in vivo; 5) although PPARalpha activation is sufficient to affect triglyceride metabolism, PPARdelta activation does not appear to modulate glucose or triglyceride levels.  (+info)

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. (5/6530)

Streptozotocin (STZ), a glucose analogue known to induce diabetes in experimental animals, causes DNA strand breaks and subsequent activation of poly(ADPribose) polymerase (Parp). Because Parp uses NAD as a substrate, extensive DNA damage will result in reduction of cellular NAD level. In fact, STZ induces NAD depletion and cell death in isolated pancreatic islets in vitro. Activation of Parp therefore is thought to play an important role in STZ-induced diabetes. In the present study, we established Parp-deficient (Parp-/-) mice by disrupting Parp exon 1 by using the homologous recombination technique. These mice were used to examine the possible involvement of Parp in STZ-induced beta-cell damage in vivo. The wild-type (Parp+/+) mice showed significant increases in blood glucose concentration from 129 mg/dl to 218, 370, 477, and 452 mg/dl on experimental days 1, 7, 21, and 60, respectively, after a single injection of 180 mg STZ/kg body weight. In contrast, the concentration of blood glucose in Parp-/- mice remained normal up to day 7, slightly increased on day 21, but returned to normal levels on day 60. STZ injection caused extensive necrosis in the islets of Parp+/+ mice on day 1, with subsequent progressive islet atrophy and loss of functional beta cells from day 7. In contrast, the extent of islet beta-cell death and dysfunction was markedly less in Parp-/- mice. Our findings clearly implicate Parp activation in islet beta-cell damage and glucose intolerance induced by STZ in vivo.  (+info)

Inhibition of advanced glycation endproduct formation by acetaldehyde: role in the cardioprotective effect of ethanol. (6/6530)

Epidemiological studies suggest that there is a beneficial effect of moderate ethanol consumption on the incidence of cardiovascular disease. Ethanol is metabolized to acetaldehyde, a two-carbon carbonyl compound that can react with nucleophiles to form covalent addition products. We have identified a biochemical modification produced by the reaction of acetaldehyde with protein-bound Amadori products. Amadori products typically arise from the nonenzymatic addition of reducing sugars (such as glucose) to protein amino groups and are the precursors to irreversibly bound, crosslinking moieties called advanced glycation endproducts, or AGEs. AGEs accumulate over time on plasma lipoproteins and vascular wall components and play an important role in the development of diabetes- and age-related cardiovascular disease. The attachment of acetaldehyde to a model Amadori product produces a chemically stabilized complex that cannot rearrange and progress to AGE formation. We tested the role of this reaction in preventing AGE formation in vivo by administering ethanol to diabetic rats, which normally exhibit increased AGE formation and high circulating levels of the hemoglobin Amadori product, HbA1c, and the hemoglobin AGE product, Hb-AGE. In this model study, diabetic rats fed an ethanol diet for 4 weeks showed a 52% decrease in Hb-AGE when compared with diabetic controls (P < 0.001). Circulating levels of HbA1c were unaffected by ethanol, pointing to the specificity of the acetaldehyde reaction for the post-Amadori, advanced glycation process. These data suggest a possible mechanism for the so-called "French paradox," (the cardioprotection conferred by moderate ethanol ingestion) and may offer new strategies for inhibiting advanced glycation.  (+info)

The influence of NO synthase inhibitor and free oxygen radicals scavenger--methylene blue--on streptozotocin-induced diabetes in rats. (7/6530)

The excessive production of nitric oxide (NO) and the subsequent increase of local oxidative stress is suggested as one of the pathophysiological mechanisms of streptozotocin-induced diabetes. It was reported that the administration of NO synthase inhibitors partially attenuated the development of streptozotocin-induced diabetes and reduced hyperglycaemia. Here we have studied the influence of methylene blue, which combines the properties of NO synthase inhibitor with antioxidant effects. The experiments were performed on male rats divided into four groups: control, diabetic (single dose of 70 mg of streptozotocin/kg i.p.), methylene blue (50 mg/kg in the food) and diabetic simultaneously fed with methylene blue. After 45 days the experiments were discontinued by decapitation. Serum glycaemia, glycated haemoglobin and oxidative stress parameters (plasma malondialdehyde concentration and erythrocyte superoxide dismutase activity) were significantly higher in the diabetic group. Simultaneous methylene blue administration partially reduced glycaemia and glycated haemoglobin, but did not decrease oxidative stress. We conclude that NO synthase inhibitor methylene blue partially attenuates the development of streptozotocin-induced diabetes in male rats, but does not reduce the development of oxidative stress in the diabetic group.  (+info)

Alterations of heart function and Na+-K+-ATPase activity by etomoxir in diabetic rats. (8/6530)

To examine the role of changes in myocardial metabolism in cardiac dysfunction in diabetes mellitus, rats were injected with streptozotocin (65 mg/kg body wt) to induce diabetes and were treated 2 wk later with the carnitine palmitoyltransferase inhibitor (carnitine palmitoyltransferase I) etomoxir (8 mg/kg body wt) for 4 wk. Untreated diabetic rats exhibited a reduction in heart rate, left ventricular systolic pressure, and positive and negative rate of pressure development and an increase in end-diastolic pressure. The sarcolemmal Na+-K+-ATPase activity was depressed and was associated with a decrease in maximal density of binding sites (Bmax) value for high-affinity sites for [3H]ouabain, whereas Bmax for low-affinity sites was unaffected. Treatment of diabetic animals with etomoxir partially reversed the depressed cardiac function with the exception of heart rate. The high serum triglyceride and free fatty acid levels were reduced, whereas the levels of glucose, insulin, and 3,3',-5-triiodo-L-thyronine were not affected by etomoxir in diabetic animals. The activity of Na+-K+-ATPase expressed per gram heart weight, but not per milligram sarcolemmal protein, was increased by etomoxir in diabetic animals. Furthermore, Bmax (per g heart wt) for both low-affinity and high-affinity binding sites in control and diabetic animals was increased by etomoxir treatment. Etomoxir treatment also increased the depressed left ventricular weight of diabetic rats and appeared to increase the density of the sarcolemma and transverse tubular system to normalize Na+-K+-ATPase activity. Therefore, a shift in myocardial substrate utilization may represent an important signal for improving the depressed cardiac function and Na+-K+-ATPase activity in diabetic rat hearts with impaired glucose utilization.  (+info)

Influence of Experimental Diabetes Mellitus on Secretary Granules in ß-Cells in the Dog Pancreatic Islet, Yuji Asai, Hiroyuki Morimoto, Yoshio Mabuchi1, Eisuke Sakuma, Nobuyuki Sh
Uncoupling Endothelial Nitric Oxide Synthase Is Ameliorated by Green Tea in Experimental Diabetes Mellitus by Re-Establishing Tetrahydrobiopterin ...
This study is an attempt to elucidate of agmatine effects upon leukocyte apoptosis in experimental diabetes mellitus (EDM). We demonstrated the increase in numbers of the leukocytes with both early and late signs of apoptosis at diabetes. Further changes in the morphofunctional state of the leukocyt …
In the present study, we found that tramadol has the ability to lower the plasma glucose levels of STZ-induced diabetic rats. This is consistent with our previous report that activation of opioid μ-receptors could decrease the plasma glucose concentration in STZ-induced diabetic rats (7).. Naloxone has been used in studying the relation between β-endorphin and glucose homeostasis (21). Pharmacologically, naloxone is a nonselective antagonist of opioid receptors (21), and naloxonazine is a selective antagonist of opioid μ-receptors (22). We found that naloxone and naloxonazine, at doses sufficient to block opioid μ-receptors, inhibited the plasma glucose-lowering action of tramadol in STZ-induced diabetic rats. It can thus be considered that opioid μ-receptor activation is involved in the plasma glucose-lowering action of tramadol in STZ-induced diabetic rats. Actually, either naloxone or naloxonazine given alone was ineffective in altering plasma glucose, indicating that opioid receptors ...
TY - JOUR. T1 - Proteome analysis of altered proteins in streptozotocin-induced diabetic rat kidney using the fluorogenic derivatization-liquid chromatography-tandem mass spectrometry method. AU - Tsai, Pei Yun. AU - Chen, Shih Ming. AU - Chen, Hsiang Yin. AU - Li, Yi Chieh. AU - Imai, Kazuhiro. AU - Hsu, Kuang Yang. AU - Lee, Jen Ai. PY - 2013/3. Y1 - 2013/3. N2 - To find new molecular markers for early diagnosis of diabetic nephropathy, we applied fluorogenic derivatization-liquid chromatography-tandem mass spectrometry to identify the differentially expressed proteins in the kidney of control and streptozotocin-induced diabetic rats. The Sprague-Dawley rats were injected with the sodium citrate buffer or streptozotocin and then killed after 1, 4, 12 and 24 weeks. The results showed that seven proteins were significantly changed after 1 week of injection. Only one protein had significantly changed after 4 weeks of injection. However, after 12 weeks of injection, the number of altered proteins ...
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Abstract: Participation of renal prostanoids in development of diabetes-induced nephropathy was studied in rats with streptozotocin diabetes. Development of diabetic nephropathy occurred with simultaneous decreases in production of intrarenal natriuretic, depressor prostaglandin and prostacyclin as well as with increases in content of antinatriuretic, pressor, prothrombogenic TxA2. The imbalance observed in the production of renal prostanoids contributed slightly to impairments of hemodynamics, osmo- and ion regulating functions of kidney, i.e. to formation of diabetic nephropathy in the experimental ...
The objective of this study was designed to investigate, evaluate the effect of vitamin E on streptozotocin (STZ)-induced diabetic rats by showing significant changes in blood glucose, water, food intake, lipid profile, serum urea and ceratinine level, and antioxidant enzyme parameters activity. Streptozotocin (STZ)-induced toxicity was studied in male Waster rats; each divided into four groups: G1, GII, GIII, and GIV. Control rats GI, rats treated with vitamin E (GII), STZ-induced diabetic rats (GIII), and STZ-induced diabetic rats treated with vitamin E (G1V). Moreover, vitamin E reduced (p f amount of total cholesterol, LDL, VLDL, cholesterol and triacyglycerols, and increased HDL cholesterol) and increased total amount protein in STZ-induced diabetic rats (GIV). Vitamin prevented modification in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSX-Px) and in the concentration of the lipid hydroperoxide. Finally the study suggested that vitamin E improved
TY - JOUR. T1 - Cerebral energy metabolism in streptozotocin-diabetic rats. AU - Biessels, G.J.. AU - Braun, K.P.J.. AU - Graaf, de, R.A.. AU - Eijsden, van, P.. AU - Gispen, W.H.. AU - Nicolaij, K.. PY - 2001. Y1 - 2001. N2 - Aims/hypothesis. It is increasingly evident that the brain is another site of diabetic end-organ damage. The pathogenesis has not been fully explained, but seems to involve an interplay between aberrant glucose metabolism and vascular changes. Vascular changes, such as deficits in cerebral blood flow, could compromise cerebral energy metabolism. We therefore examined cerebral metabolism in streptozotocin-diabetic rats in vivo by means of localised 31P and 1H magnetic resonance spectroscopy. Methods. Rats were examined 2 weeks and 4 and 8 months after diabetes induction. A non-diabetic group was examined at baseline and after 8 months. Results. In 31P spectra the phosphocreatine:ATP, phosphocreatine:inorganic phosphate and ATP:inorganic phosphate ratios and intracellular pH ...
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A large number of studies have documented the evidence that progression of diabetes leads to various secondary diabetic complications among which nephropathy is a serious complication with an increasing prevalence worldwide [22]. The nephropathy disease is characterized by morphological and ultra structural changes in the kidney including expansion of the molecular matrix. Even though, the pathogenesis of diabetic nephropathy is complex and still not fully elucidated, few biochemical changes such as increase in polyol pathway flux, increased AGEs formation, have been actively studied for their role in the development of diabetic nephropathy. Increased matrix proteins leading to decreased GFR is considered as a marker for the progression of the Diabetic nephropathy disease. Elevation of serum creatinine levels and BUN in diabetic rats is used as an index of altered GFR in diabetic nephropathy [23].. Results of the present study have corroborated with the previous reports in which administration ...
Background. The purpose of the study was to explore the role of the renin-angiotensin system in the disturbance of renal excretory function in the ...
The profile of hepatic microsomal cytochrome P450 expressed in the male and female rat was dramatically altered by streptozotocin-induced diabetes. In the diabetic male, P450 forms IIC11, IIC13, IIA2, and IIIA2 were suppressed and forms IIA1 and IIC12 were induced to the levels observed in the immature male rat. A 6- to 8-fold induction of P450 IIE1 was detected in both male and female diabetic rats. A member of the P450 IIIA family was also induced in the diabetic female rat. Accompanying the change in P450 profile in the diabetic male rat was reduction in circulating testosterone and tetraiodothyronine concentrations and a sharp diminution of the normally pulsatile pattern of growth hormone secretion. In contrast to the male rat, the growth hormone secretion pattern in the diabetic female rat was unchanged from control. The hormone and P450 profiles detected in the diabetic male rat suggest a reversion to an immature physiological state. Testosterone replacement treatments carried out for 2 ...
OBJECTIVE To investigate whether ageing and diabetes alter the expression of the gap junction protein connexin43 (Cx43) and of particular purinoceptor (P2R) subtypes in the corpus cavernosum and urinary bladder, and determine whether changes in expression of these proteins correlate with development of erectile and bladder dysfunction in diabetic and ageing rats. MATERIALS AND METHODS Erectile and bladder function of streptozotocin (STZ)-induced diabetic, insulin-treated and age-matched control Fischer-344 rats were evaluated 2, 4 and 8 months after diabetes induction by in vivo cystometry and cavernosometry. Corporal and bladder tissue were then isolated at each of these sample times and protein expression levels of Cx43 and of various P2R subtypes were determined by Western blotting. RESULTS In the corpora of control rats ageing was accompanied by a significant decrease in Cx43 and P2X(1)R, and increase in P2X(7)R expression. There was decreased Cx43 and increased P2Y(4)R expression in the ageing
Title:Goto-kakizaki Rats: Its Suitability as Non-obese Diabetic Animal Model for Spontaneous Type 2 Diabetes Mellitus. VOLUME: 9 ISSUE: 5. Author(s):Muhammad Sajid Hamid Akash, Kanwal Rehman and Shuqing Chen. Affiliation:Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University Hangzhou, China.. Keywords:None Obese Animal Model, GK Rats, Islet Inflammation, Insulin Resistance, Hyperglycemia, Diabetic Nephropathy, Diabetes Mellitus, Glucose Tolerance.. Abstract:β-cell dysfunction and apoptosis are recognized as a major cause of insufficient insulin secretion in response to high blood glucose and metabolic demand. As a consequence, type 2 diabetes mellitus (T2DM) is known to occur. Taking into account the etiology of T2DM, to conduct investigational studies directly on human diabetic patients seems to be unsuitable; thereby, various animal models have been established to investigate the pathogenesis of T2DM. Among these models, ...
BioAssay record AID 185258 submitted by ChEMBL: Percent inhibition of sorbitol accumulation in the sciatic nerve of streptozotocin (STZ)- induced diabetic rats at peroral dose of 30 mg/kg (preventive effect).
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TY - JOUR. T1 - Upregulation of GLUT2 mRNA by glucose, mannose, and fructose in isolated rat hepatocytes. AU - Asano, Tomoichiro. AU - Katagiri, Hideki. AU - Tsukuda, Katsunori. AU - Lin, Jiann Liang. AU - Ishihara, Hisamitsu. AU - Yazaki, Yoshio. AU - Oka, Yoshitomo. PY - 1992/1/1. Y1 - 1992/1/1. N2 - Previously, demonstrated that GLUT2 mRNA and protein are increased in liver of streptozocin-induced diabetic rats. To examine the mechanisms whereby GLUT2 mRNA is regulated, we cultured isolated hepatocytes in the absence and presence of various concentrations of glucose. Culture of hepatocytes in high glucose concentration (27.8 mM) for 20 h induced a 3.2-fold increase in GLUT2 mRNA levels compared with hepatocytes cultured without D-glucose. Interestingly, D-mannose and D-fructose could substitute for D-glucose to elevate the GLUT2 mRNA level, whereas 3-O-methyl-D-glucose, 2-deoxy-D-glucose, and sucrose, which were not metabolized or taken up by the cells, were without effect. Insulin had no ...
The aim of the present study was to investigate the relationship between speed during maximum exercise test (ET) and oxygen consumption (VO2) in control and STZ-diabetic rats, in order to provide a useful method to determine exercise capacity and prescription in researches involving STZ-diabetic rats. Male Wistar rats were divided into two groups: control (CG, n = 10) and diabetic (DG, n = 8). The animals were submitted to ET on treadmill with simultaneous gas analysis through open respirometry system. ET and VO2 were assessed 60 days after diabetes induction (STZ, 50 mg/Kg). VO2 maximum was reduced in STZ-diabetic rats (72.5 ± 1 mL/Kg/min-1) compared to CG rats (81.1 ± 1 mL/Kg/min-1). There were positive correlations between ET speed and VO2 (r = 0.87 for CG and r = 0.8 for DG), as well as between ET speed and VO2 reserve (r = 0.77 for CG and r = 0.7 for DG). Positive correlations were also obtained between measured VO2 and VO2 predicted values (r = 0.81 for CG and r = 0.75 for DG) by linear
TY - JOUR. T1 - Proteomics analysis identifies molecular targets related to diabetes mellitus-associated bladder dysfunction. AU - Yohannes, Elizabeth. AU - Chang, Jinsook. AU - Christ, George J.. AU - Davies, Kevin P.. AU - Chance, Mark R.. PY - 2008/7. Y1 - 2008/7. N2 - Protein expression profiles in rat bladder smooth muscle were compared between animal models of streptozotocin-induced diabetes mellitus (STZ-DM) and age-matched controls at 1 week and 2 months after induction of hyper-glycemia with STZ treatment. At each time point, protein samples from four STZ-DM and four age-matched control rat bladder tissues were prepared independently and analyzed together across multiple DIGE gels using a pooled internal standard sample to quantify expression changes with statistical confidence. A total of 100 spots were determined to be significantly changing among the four experimental groups. A subsequent mass spectrometry analysis of the 100 spots identified a total of 56 unique proteins. Of the ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
Renal protection against diabetes-induced pathogenic injuries by multiple exposures to low-dose radiation (LDR) was investigated to develop a novel approach to the prevention of renal disease for diabetic subjects. C57BL/6J mice were given multiple low-dose streptozotocin (STZ; 60 x 6 mg/kg) to produce a type 1 diabetes. Two weeks after diabetes onset, some of diabetic mice and age-matched nondiabetic mice were exposed whole body to 25 mGy X-rays every other day for 2, 4, 8, 12, and 16 wk. Diabetes caused a significant renal dysfunction, shown by time-dependent increase in urinary microalbumin (Malb) and decrease in urinary creatinine (Cre), and pathological changes, shown by significant increases in renal structural changes and PAS-positive staining. However, diabetes-induced renal dysfunction and pathological changes were significantly, albeit partially, attenuated by multiple exposures to LDR. Furthermore, LDR protection against diabetes-induced renal dysfunction and pathological changes was ...
Diabetes mellitus (DM) is metabolic diseases characterized by chronic hyperglycemia due to reducing in insulin secretion, insulin function, or both. Ezetimibe is a drug that lowers plasma cholesterol levels. A total of 18 male adult albino rats were used in this study. The animals randomized into 3 groups (of 6 rats each). Rats in first group were injected with citrate buffer only and used as healthy control group. While the rats in other two groups were injected with streptozotocin (STZ) at a dose of 60 mg/kg I.P. and treated as following (for 12 weeks), diabetic control group rats received no treatment. Ezetimibe treated group rats received Ezetimibe 6 mg/kg orally once daily. Every 2 weeks, blood glucose level is measured. At the end of 12th weeks, blood samples were collected to measure the blood glucose level and superoxide dismutase activity, and then the animals were sacrificed. The pancreas was removed for histopathology assessment for the degree of islets damage. In result, Ezetimibe was
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
Untreated diabetes leads to damage to the blood vessels and their consequences. atherosclerosis, coronary artery disease, damage to the retina of the eye and kidney disease.
A balanced meal according to the Atkins Diet. How Diabetes Affects Your Diet Quotes Being hIGHLIGHTS OF PRESCRIBING INFORMATION disposable prelled pen (3) before stopping IV insulin. A meta-analysis of rectal NSAIDs in the prevention of post-ERCP pancreatitis. Tags: Diseases & Conditions Diabetes Healthy food Type 2 diabetes Curd Yoghurt. In Type 1 diabetes the disease is caused by the destruction of beta cells in the pancreas. Guidelines developed by the American Geriatrics Association reflect some of the unique diabetes care needs of older adults. a flexible meal plan has been proposed in adolescents with type 1 diabetes where insulin.. We also offer a large selection of accessories for your special day. Optimum HealthCare Inc. Stress is a potential contributor to chronic hyperglycemia in diabetes.. My husband loves this casserole but it Diabetic Exchanges: 3 lean Originally published as Enchilada Casser-Ole! in Healthy Cooking Feuary/March atherosclerosis in mice with liver-specific ablation ...
Characterisation of animal models of diabetic cardiomyopathy may help unravel new molecular targets for therapy. Long-living individuals are protected from the adverse influence of diabetes on the heart, and the transfer of a longevity-associated variant (LAV) of the human BPIFB4 gene protects cardiac function in the db/db mouse model. This study aimed to determine the effect of LAV-BPIFB4 therapy on the metabolic phenotype (ultra-high-performance liquid chromatography-mass spectrometry, UHPLC-MS) and cardiac transcriptome (next-generation RNAseq) in db/db mice. UHPLC-MS showed that 493 cardiac metabolites were differentially modulated in diabetic compared with non-diabetic mice, mainly related to lipid metabolism. Moreover, only 3 out of 63 metabolites influenced by LAV-BPIFB4 therapy in diabetic hearts showed a reversion from the diabetic towards the non-diabetic phenotype. RNAseq showed 60 genes were differentially expressed in hearts of diabetic and non-diabetic mice. The contrast between LAV-BPIFB4
In this study, the diabetic model was generated by a single large-dose injection of STZ. Under such conditions, STZ destroys β-cells via DNA alkylation (Lenzen, 2008). The model differs from the autoimmune diabetic model of non-obese diabetes (NOD) or multiple low-dose STZ-induced diabetes, where islet inflammation is the salient pathological feature (Bassi et al., 2012; Ezquer et al., 2012; George et al., 2002; Leiter, 1982; Paik et al., 1980). The non-inflammatory diabetic model used here, which was confirmed by the lack of inflammatory cell infiltrates in the islet of untransplanted but STZ-treated rats (Fig. 2B), allows us to better examine the direct trophic effect of uMSCs on β-cell survival with fewer complications from their immunomodulatory activities. In this study, uSMC transplantation retarded the hyperglycemic progression 6 days after the treatment, yet the treatment only modestly reversed hyperglycemia despite the extended 42-day treatment. Multiple factors might influence the ...
by David M. Reutter. A $1 million settlement was reached in May 2019 in a lawsuit alleging the Atlanta City Detention Center (ACDC) left a pretrial detainee in an unlit confinement cell to die from untreated diabetes.. When Wickie Yvonne Bryant, 55, was booked into ACDC on September 14, 2015, it was noted that she suffered from schizophrenia, bipolar disorder, diabetes, and hypertension. She said that she was taking medication for all three diagnoses. An intake test revealed an extremely elevated blood-glucose level of 353 mg/dl, but she refused to take insulin, saying it made her sick.. She was subsequently prescribed Metformin, an oral diabetic medication. Yet, from her intake until October 5, 2015, Bryant refused her diabetic treatment, which meant blood testing and medication. She submitted a request on September 20 advising officials about her medical and mental health treatment at several medical facilities.. Despite laying out her history of care regimen, ADCDs medical staff never ...
What percent of patients with type 2 diabetes have already developed one or more microvascular complications by the time of their diabetes diagnosis, according to the American Diabetes Association (ADA)? ...
The present study is aimed to evaluate the hypoglycaemic effect of glibenclamide monotherapy on streptozotocin-induced diabetic rats and therapeutic i..
Learn how Diabetes leads to Anemia and what Anemia is, learn about the connection between the damage of your Kidneys and Diabetes.
Axonal swellings in neurons from STZ-diabetic rats exposed to high glucose represent accumulations of mitochondria and phosphorylated NFH, which are eliminated
The present study is aimed to evaluate the hypoglycaemic effect of glibenclamide monotherapy on streptozotocin-induced diabetic rats and therapeutic impact of this agent on various..
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Diabetic nephropathy (DN) is a major complication of diabetes and is caused by an imbalance in the expression of certain genes that activate or inhibit vital cellular functions of kidney. Despite several recent advances, the pathogenesis of DN remains far from clear, suggesting the need to carry out studies identifying molecular aspects, such as gene expression, that could play a key role in the development of DN. There are several techniques to analyze transcriptome in living organisms. In this study, the suppression subtractive hybridization (SSH) method was used to generate up- and down-regulated subtracted cDNA libraries in the kidney of streptozotocin (STZ)-induced diabetic rats. Northern-blot analysis was used to confirm differential expression ratios from the obtained SSH clones to identify genes related to DN. 400 unique SSH clones were randomly chosen from the two subtraction libraries (200 of each) and verified as differentially expressed. According to blast screening and functional annotation
Objective: It is increasingly recognized that vascular cognitive impairment may be a new complication of the disease in both type 1 and type 2 diabetes. We have shown that diabetic Goto-Kakizaki rats present with cognitive deficits and vascular dysfunction, especially impaired relaxation that can be ameliorated by Toll-like receptor-2 (TLR2) inhibition. Since brain function heavily depends on constant perfusion, and decreased cerebral blood flow (CBF) precedes development of inflammation and cognitive deficits, we hypothesized that TLR2 knockout would confer a protection from diabetes mediated cognitive decline.. Methods and Results: Wild-type (WT) and TLR2 knockout (KO) control and diabetic mice were used. Diabetes was induced by streptozotocin (STZ) injection. 14 weeks after, cerebral perfusion was measured by MRI and cognitive function was assessed by a battery of tests including Y-maze and fear conditioning. There was no difference in cerebral perfusion in WT and TLR2 KO mice (CBF ...
How Diabetes affects your Feet: pain, pain relief, tingling, pins and needles sensations, complications, symptoms of complications, how to prevent complications
Diabetes-induced visual dysfunction is associated with significant neuroretinal cell death. The current study was designed to investigate the role of the Protein Regulated in Development and DNA Damage Response 1 (REDD1) in diabetes-induced retinal cell death and visual dysfunction. We recently demonstrated that REDD1 protein expression was elevated in response to hyperglycemia in the retina of diabetic rodents. REDD1 is an important regulator of Akt and mammalian target of rapamycin and as such plays a key role in neuronal function and survival. In R28 retinal cells in culture, hyperglycemic conditions enhanced REDD1 protein expression concomitant with caspase activation and cell death. By contrast, in REDD1-deficient R28 cells, neither hyperglycemic conditions nor the absence of insulin in culture medium were sufficient to promote cell death. In the retinas of streptozotocin-induced diabetic mice, retinal apoptosis was dramatically elevated compared with nondiabetic controls, whereas no ...
Treatment of male Sprague-Dawley rats with streptozotocin resulted in a blood glucose level of over 400 mg/dL within one week (| 350 is considered diabetic). Subsequent treatment with the insulin-mimetic agents vanadate and selenate affected how much food the rats consumed as well as their growth rate when compared to controls. Diabetic controls consumed more food and gained weight more quickly than their treated counterparts. Non-diabetic controls (which were not injected with streptozotocin) consumed less food than the diabetic animals but gained more weight. Regulation of G6PDH and FAS at the level of gene expression is well documented, and preliminary studies show that diabetic rats treated with vanadate or selenate exhibit a stimulation in the enzyme activities of (G6PDH) and (FAS) above diabetic control levels. Thus, it seems that both vanadate and selenium have some regulatory influence that is similar to insulin over the enzyme activities of G6PDH and FAS.
Results-After stroke, mice with diabetes mellitus exhibited significantly increased lesion volume and brain hemorrhagic and neurological deficits compared to mice without diabetes mellitus. Bielshowsky silver, luxol fast blue, amyloid precursor protein, and NG2 expression were significantly decreased, indicating WM damage, and matrix metalloproteinase (MMP)-9 activity was significantly increased in the ischemic brain of mice with diabetes mellitus. Subanalysis of similar lesions in mice with and without diabetes mellitus demonstrated mice with diabetes mellitus had significantly increased WM damage than in mice without diabetes mellitus (P,0.05). To investigate the mechanism underlying diabetes mellitus-induced WM damage, oxygen-glucose deprivation-stressed premature oligodendrocyte and primary cortical neuron cultures were used. High glucose increased MMP-2, MMP-9, cleaved caspase-3 levels, and apoptosis, as well as decreased cell survival and dendrite outgrowth in cultured primary cortical ...
DESCRIPTION (provided by applicant): Acute stroke is one of the most under-treated serious diseases in the United States. A major challenge in the study of stroke is that most treatments effective in experimental animals have failed in humans. One possible explanation is that targets for protection have been identified in otherwise healthy animals upon which focal cerebral ischemia has been imposed. Type 2 diabetes that is often accompanied by hypertension is the most rapidly increasing risk factor for stroke and also increases the risk of hemorrhage and poor outcome of stroke. While it is known that the integrity of cerebral blood vessels is critical in the pathophysiology of stroke, targets to protect the vasculature from ischemic injury in the presence of preexisting vascular disease are yet to be identified. The objective of this application is to conduct feasibility studies to test our global hypothesis that diabetes-induced changes in the cerebral microvessel wall increase the risk of ...
TY - JOUR. T1 - Improvement of gastric motility with gastric electrical stimulation in STZ-induced diabetic rats. AU - Liu, Jinsong. AU - Qiao, Xian. AU - Micci, Maria Adelaide. AU - Pasricha, Pankaj J.. AU - Chen, J. D.Z.. PY - 2004/12/1. Y1 - 2004/12/1. N2 - Aims: The aims of this study were to observe whether gastric motility was impaired in streptozotocin (STZ)-induced diabetic rats and whether gastric electrical stimulation was able to restore the impaired motility. Methods: Ten control rats and 30 STZ-induced diabetic rats were used in this study. Gastric slow waves were recorded at baseline and 0, 1, 2, 3 and 4 weeks after the injection of STZ or vehicle. Gastric emptying with (long or short pulses) or without gastric electrical stimulation was measured 6 weeks after STZ injection in a group of 10 diabetic rats each. Results: (1) STZ injection resulted in hyperglycemia and weight loss. (2) Gastric motility was impaired in the diabetic rats. The percentage of normal slow waves was ...
TY - JOUR. T1 - Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats. AU - Huang, Wei Jan. AU - Niu, Ho Shan. AU - Lin, Mei Hsiang. AU - Cheng, Juei Tang. AU - Hsu, Feng-Lin. PY - 2010/6/25. Y1 - 2010/6/25. N2 - The antihyperglycemic effect of catalpol (1) purified from the roots of Rehmannia glutinosa was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) representing insulin-dependent diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 0.1 mg/kg 1 significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. Catalpol enhanced the uptake of radioactive glucose in the isolated soleus muscle of STZ-diabetic rats in a concentration-related manner. Moreover, an effect by 1 was established on glycogen incorporation in hepatocytes isolated from STZ-diabetic rats. Catalpol was found to increase ...
The exact nature of poor wound healing in diabetes is uncertain. Neutrophils play a critical role in the host defense mechanism, and it is suggested that impaired neutrophil functions cause healing difficulties with or without infections in diabetic patients. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is used clinically when given systematically to increase the circulating neutrophils, but its wound-healing effects have not been systematically studied. This study was undertaken to examine the effects of GM-CSF on incisional wound healing in an experimental diabetic rat model. Forty rats were randomly divided into three groups, group I receiving saline as control, diabetes-induced group II receiving saline and diabetes-induced group III receiving GM-CSF. The anesthetized rats in all groups were wounded 21 days after diabetes induction by streptozotocin. Blood neutrophil counts and neutrophil fractions were also determined three days after wounding. Tensile strengths of wounded skin ...
TY - JOUR. T1 - Enhanced contractile responses of arteries from streptozotocin diabetic rats to sodium fluoride. AU - Weber, Lynn P.. AU - Chow, Wing Lim. AU - Abebe, Worku. AU - MacLeod, Kathleen M.. PY - 1996/5/13. Y1 - 1996/5/13. N2 - 1. Previous studies from this laboratory have demonstrated that α1-adrenoceptor-mediated increases in tension and phosphoinositide metabolism are enhanced in the aorta and mesenteric arteries from diabetic rats. The purpose of the present investigation was to determine whether contractile responses to sodium fluoride (NaF), which directly stimulates GTP-binding proteins (G-proteins), are also enhanced in diabetic arteries. 2. NaF (1-20mM) in the presence of 10 μM aluminium chloride produced slowly developing, concentration-dependent contractions in mesenteric arteries from three month streptozotocin-diabetic (60 mg kg -1, i.v.) male Wistar rats and age-matched control rats. The maximum contractile response but not the sensitivity to NaF was significantly ...
It has been suggested that Sorghum, a rich source of phytochemicals, has a hypoglycemic effect, but the mechanism is unknown. We investigated the effects of oral administration of sorghum extract (SE) on hepatic gluconeogenesis and the glucose uptake of muscle in streptozotocin-induced diabetic rats for six weeks. Male Wistar rats were divided in five groups (n=5 per group): normal control (NC), rats with STZ-induced diabetic mellitus (DM), diabetic rats administrated 0.4 g/kg body weight of SE (DM-SE 0.4) and 0.6 g/kg body weight of SE (DM-SE 0.6), and diabetic rats administrated 0.7 mg/kg body weight of glibenclamide (DM-G). Administration of SE and G reduced the concentration of triglycerides, total and LDL-cholesterol and glucose, and the area under the curve of glucose during intraperitoneal glucose tolerance tests down to the levels observed in non-diabetic rats. In addition, administration of 0.4 and 0.6 g/kg SE and 0.7 mg/kg glibenclamide (G) significantly reduced the expression of
Diabetics often have elevated levels of serum lipids and cholesterol and increased risk of cardiovascular disease. Streptozotocin-induced diabetes was used to determine whether elevated serum cholesterol levels in diabetics are due to loss of control of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the committed step in cholesterol synthesis. Strain A/ST female mice were fed 10% corn oil diets, half with 2% cholesterol. Experimental groups were injected with 9.0 mg streptozotocin / 100g body weight. Diabetes was confirmed by weight loss, elevated blood sugars, and enlarged spleens. Reductase activity was assayed spectrophotometrically. Serum cholesterol levels were determined by gas liquid chromatography. Both diabetic and control mice fed cholesterol had elevated serum cholesterol levels and decreased reductase activities. These observations suggest that HMG CoA reductase is not the primary control point in the control of serum cholesterol levels in diabetic mice. The ...
PubMed journal article: Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice. Download Prime PubMed App to iPhone, iPad, or Android
The present work has detected the antidiabetic effect of the MLE in alloxan-induced diabetic rats. Alloxan causes a massive reduction in insulin release, by the destruction of the beta cells of the islets of Langerhans and inducing hyperglycemia [17]. MLE lowered the blood glucose levels in normal rats within and in glucose loaded animals, in which the pancreatic cells are still fully intact. Hydroethanolic extract of the drug might be able to stimulate insulin secretion in normal rats, as did glibenclamide. Thus the results obtained show that oral administration of MLE produces a significant decrease in blood glucose levels in alloxan diabetic rats on both acute and long term administration. In contrast, the significant increase in plasma glucose levels of untreated diabetic rats may be due to progressive severity of untreated diabetes. The most common lipid abnormalities in diabetes are hypertriglyceridemia and hypercholesterolemia [18]. Hypertriglyceridemia is also associated in metabolic ...
Traditional plant treatment for diabetes has shown a surging interest in the last few decades. Therefore, the purpose of this study was to assess the hypoglycemic effect of the aqueous extract of C. papaya leaves in diabetic rats. Several studies have reported that some parts of the C. papaya plant exert hypoglycemic effects in both animals and humans. Diabetes was induced in rats by intraperitoneal administration of 60 mg/kg of streptozotocin (STZ). The aqueous extract of C. papaya was administered in three different doses (0.75, 1.5 and 3 g/100 mL) as drinking water to both diabetic and non-diabetic animals during 4 weeks. The aqueous extract of Carica papaya (0.75 g and 1.5 g/100 mL) significantly decreased blood glucose levels (p|0.05) in diabetic rats. It also decreased cholesterol, triacylglycerol and amino-transferases blood levels. Low plasma insulin levels did not change after treatment in diabetic rats, but they significantly increased in non-diabetic animals. Pancreatic islet cells were
The present study investigated the possible protective effect of Helicteres isora (Sterculiaceae) bark extracts on certain biochemical markers in streptozotocin (STZ)-induced diabetes in rats. STZ treatment (60 mg/kg/i.p) caused a hyperglycemic state that led to various physiological and biochemical alterations. Blood levels of glucose, urea, uric acid and creatinine, plasma levels of albumin and albumin/globulin ratio and the activities of diagnostic marker enzymes including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and ?-glutamyl transpeptidase (? -GT) in plasma, liver and kidney were markedly altered in STZ diabetic rats. Oral administration of H. isora (100, 200 mg/kg/p.o) for 21 days restored all these biochemical parameters to near normal levels. Thus, the present results have shown that H. isora bark extract has the antihyperglycemic effect and consequently may alleviate liver and renal damage associated with STZ-induced diabetes in rats.
Imidazoline I1-receptors (I1R) are known to regulate blood pressure and rilmenidine, an agonist, is widely used as antihypertensive agent in clinic. However, the role of I1R in feeding behavior is still unclear. In the present study, we used the agonist of I1R to investigate the effect on hyperphagia in streptozotocin (STZ)-induced diabetic mice. Rilmenidine decreased the food intake of STZ-diabetic mice in a dose-dependent manner. The reduction of food intake was abolished by pretreatment with efaroxan at the dose sufficient to block I1R. Intracerebroventricular (icv) administration of rilmenidine into STZ-diabetic mice also significantly reduced hyperphagia, which was reversed by icv administration of efaroxan. In addition, similar results were observed in STZ-diabetic mice, which received chronic treatment with rilmenidine 3 times daily (t.i.d.) for 7 days. Moreover, the hypothalamic neuropeptide Y (NPY) level was reduced by rilmenidine that was also reversed by pretreatment with efaroxan. In ...
The study examined the antioxidant activities and anti-inflammatory effects of rutin from the streptozotocin (STZ)-induced diabetic rats. Results revealed that the levels of plasma glucose and serum glucose were remarkably higher in the STZ-treated group compared to other groups and were significantly reduced in the STZ+rutin treated group compared to the STZ-treated group. In terms of weight, it significantly increased in all experimental groups during the experiment period except for STZ-induced diabetic group. The weight of the STZ-treated group was remarkably reduced compared to other groups. Regarding the weight of each body organ, the STZ-treated group showed higher organ weight compared to the other groups while STZ+rutin-treated group showed significantly reduced kidney and liver weights compared to those of STZ-treated group. In the pancreas tissue of the STZ-treated group, β-cell destruction and vacuolization were observed. Inflammation in the heart, liver, kidney, and retina tissues ...
TY - JOUR. T1 - Vascular Endothelium and Smooth Muscle Remodeling Accompanies Hypertrophy of Intestinal Arterioles in Streptozotocin Diabetic Rats. AU - Connors, Bret A.. AU - Bohlen, H.. AU - Evan, Andrew. PY - 1995/5. Y1 - 1995/5. N2 - The purpose of this study was to document alterations in endothelial and smooth muscle cell morphology of first- and second-order intestinal arterioles after 6 months of streptozotocin-induced diabetes. Both light and scanning electron microscopic techniques were used to quantitate the changes in the microvasculature. After rendering the first- and second-order intestinal arterioles passive and processing the vessels, it was determined that these microvessels were significantly dilated in the diabetic animals. Further examination revealed that in the diabetic animals, the cross-sectional area of the endothelial layer was increased in both 1A and 2A vessels, and the smooth muscle layer cross-sectional area was significantly increased in 1A vessels. Individual ...
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TY - JOUR. T1 - Investigating structural and biochemical correlates of ganglion cell dysfunction in streptozotocin-induced diabetic rats. AU - Bui, Bang. AU - Loeliger, Michelle. AU - Thomas, Merlin. AU - Vingrys, Algis. AU - Rees, Sandra. AU - Nguyen, Christine. AU - He, Zheng. AU - Tolcos, Mary. PY - 2009. Y1 - 2009. N2 - The aim of this study was to determine whether inner retinal dysfunction in diabetic rats is correlated with structural and/or biochemical changes in the retina and optic nerve. Using the electroretinogram (ERG; -5.83 to 1.28 log cd.s.m(-2)) retinal function (photoreceptor, bipolar, amacrine and ganglion cell components) was measured in control (n=13; citrate buffer) and diabetic (n=13; streptozotocin, STZ, 50 mg kg(-1)) rats, 12 weeks following treatment. Retinae and optic nerves were analyzed for structural changes and retinae were assessed for alterations in growth factor/cytokine expression using quantitative real-time PCR. We found that phototransduction efficiency was ...
Purpose: Pulsed magnetic field (PMF) as an important non- invasive alternative therapeutic option has been investigated in several pre-clinical and clinical studies. We also hypothesized that sequenced PMF formed with different frequencies can modulate the diabetes-induced neuropathic signs differently.Materials and methods: Therapeutic actions of sequenced PMF including 1, 5, 1, 5 Hz (low (L)-PMF) or 30, 40, 30, 40 Hz (high (H)-PMF) were examined on improving signs and symptoms of diabetic neuropathic pain in the streptozotocin-induced diabetic rat models by measuring nociceptive parameters such as hyperalgesia and allodynia, and various cytokine levels (tumor necrosis factor [TNF]-alpha, interleukin [IL]-1 beta, IL-6 and IL-10) of spinal cord and sciatic nerve tissues.Results: Ameliorating potential of L-PMF application on signs of diabetes is significantly higher than those of H-PMF. L-PMF partially attenuated the diabetes-induced increase in the blood glucose level, enhanced the decreased ...
Diabetes mellitus is associated with altered iron homeostasis in both human and animal diabetic models. Iron is a metal oxidant capable of generating reactive oxygen species (ROS) and has been postulated to contribute to diabetic nephropathy. Two proteins involved in iron metabolism that are expressed in the kidney are the divalent metal transporter, DMT1 (Slc11a2), and the Transferrin Receptor (TfR). Thus, we investigated whether renal DMT1 or TfR expression is altered in diabetes, as this could potentially affect ROS generation and contribute to diabetic nephropathy. Rats were rendered diabetic with streptozotocin (STZ-diabetes) and renal DMT1 and TfR expression studied using semi-quantitative immunoblotting and immunofluorescence. In STZ-diabetic Sprague-Dawley rats, renal DMT1 expression was significantly reduced and TfR expression increased after 2 weeks. DMT1 downregulation was observed in both proximal tubules and collecting ducts. Renal DMT1 expression was also decreased in Wistar rats ...
Free Online Library: The use of alloxan and streptozotocin in experimental diabetes models by Turkish Journal of Endocrinology and Metabolism; Health, general Diabetes Diabetes mellitus Pyrimidines Streptozocin
Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A 1H NMR-based metabolomics investigation. Related
Objectives: Oxidative stress plays a central role in diabetes-induced complications. In the present study, the protevtive effect of Artemisia turanica (A. turanica) was evaluated against diabetes-induced liver oxidative stress and dysfunction. Methods: Fifty male Wistar rats were randomly divided into five groups: control, diabetic, diabetic + metformin, diabetic + A. turanica extract, and diabetic + A. turanica extract + metformin. Experimental diabetes was induced by a single-dose (55 mg/kg, intraperitoneally (ip)) injection of streptozotocin (STZ). Metformin (300 mg/kg) and A. turanica extract (70 mg/kg) were orally administrated three days after STZ injection for four weeks. The levels of malondialdehyde (MDA), total thiol content and superoxide dismutase (SOD) and catalase activities were measured in the liver tissue. Serum glucose concentration, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were also determined. Results: In the diabetic group, serum glucose
Abnormal cannabidiol (Abn-CBD) and AS-1269574 are potent selective agonists for GPR55 and GPR119, respectively. The present study evaluated the actions and
In our study, experimental induction of diabetes mellitus resulted in diabetic nephropathy, which was assessed by measuring 24hrs. Urinary albumin excretion, serum creatinine, and serum urea on the 12 th week of the experiment. It was noted that there was a significant increase in urinary albumin excretion, serum creatinine, and serum urea noted in rats after STZ administration. This is in agreement with Mianzhi et al. (2012). Various factors are involved in the pathogenesis of diabetic nephropathy. It is believed that hyperglycemia induces a defect in the mitochondrial electron transport chain, resulting in increased production of reactive oxygen species and increased oxidative stress. This is a common mediator of the pathophysiological effects of hyperglycemia and subsequent diabetic nephropathy [41]. The increased oxidative stress activates glycation and formation of advanced glycation end products with the formation of cytokines and growth factors [42]. Also increased angiotensin II plays an ...
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The present work was executed to evaluate the anti-diabetic potency of a polyherbal preparation. The objective of this study is to induce experimental diabetes mellitus using Alloxan in normal Albino wistar rats and study the anti-diabetic activity of polyherbal formulation by comparison of changes in body weight and levels of glucose between normal and diabetic rats. Hypoglycemic agents from natural and synthetic sources are available for treatment of diabetes. Indian medicinal plants have been found to be useful to successfully manage diabetes.
Our study is the first to document that HDAC inhibition preserves cardiac performance and suppresses cardiac remodeling in diabetic cardiomyopathy. Specifically, (1) Serial echocardiographic evaluation indicates that HDAC inhibition resulted in the preservation of ventricular function in STZ-induced diabetic heart; (2) HDAC inhibition plays a profound effect in suppressing interstitial fibrosis and attenuating myocyte hypertrophy in the diabetic myocardium; (3) HDAC inhibition mitigated the frequencies of apoptosis in the diabetic myocardium by decreasing active caspase 3 and TUNEL positive signals; (4) HDAC inhibition resulted in the increase of SOD1, GLUT1, and GLUT4 protein levels in diabetic hearts, and acetylation of GLUT1 was elevated following HDAC inhibition; (5) Diabetic hearts exhibited significant decreases in CD31 and α-SMA positive microvessels, which was prevented following HDAC inhibition.. Recent evidence has indicated a genetic association between diabetes and HDACs. HDAC ...
We and others recently observed that heparin, and more generally GAG, can prevent or cure experimental diabetic nephropathy (19,20,21,27,28). This study demonstrates that chronic GAG/mH treatment of long-term (12 mo) diabetic animals prevents albuminuria, glomerular increases in PAS staining, collagen III accumulation, and, as shown in earlier studies, enhanced collagen α1 (IV) accumulation and synthesis and basement membrane thickening (20,21). Together, these data demonstrate that the treatment ameliorates the functional and structural renal changes associated with diabetes mellitus.. To investigate the molecular mechanisms of the inhibitory effects of GAG, renal TGF-β1 expression was studied. In accordance with a previous study of short-term diabetic rats (29), increased glomerular and tubular expression of TGF-β1 mRNA was observed for our long-term diabetic animals. TGF-β1 protein levels were also increased in many cortical tubules of diabetic animals. However, we observed no significant ...
Type 1.5 diabetes insulin is required in half of those with Type 1.5 diabetes within four years of diagnosis diabetes treatment People with diabetes cant eat anything sweet. Diabetes Cause Of Death In Us Can Juice Drink Sugarcane 25419 likes 6680 talking about this. PHE customizes Power-Pak C.. Rising health care premiums anger Diabetes Cause Of Death In Us Can Juice Drink Sugarcane those paying full price. weight watcher meatloaf recipe. called Diabetes Warriorwww.diabetes -warrior.net Juvenile Diabetes Research Foundation Buffalo diabetes guidelines powerpoint. Spend some time in uniform and these things will seem like gourmet meals.. Effect of supplemental antioxidants vitamin C vitamin Left uncontrolled the consequences of type 2 diabetes can be life-threatening. Your blood pressure reading has 2 numbers. Type 2 diabetes diabetes omega 3 fish oil pictures toes metabolic syndrome We know that gestational diabetes is often cured when So the liver is not the cause of diabetes. Californias ...
Background: Vascular disease is the principal cause of morbidity and mortality in patients with diabetes. A considerable body of evidence implicates oxidative stress as an important pathogenic factor of diabetic vasculopathies. In the present study, the effect of hesperidin, a flavanone glycoside with antioxidant activity, is studied in endothelium-dependent relaxation of the rat aorta in experimental diabetes mellitus type 1 (DM1) and type 2 (DM2). Patients and Methods: Single dose intraperitoneal injection of streptozocin (60mg/kg) and subcutaneous daily injection of dexamethasone (10μg/kg for one month) were used to induce DM1 and DM2, respectively. Hesperidin (500mg/kg) was administered orally for two months in DM1 and one month in DM2. The effect of acetylcholine (Ach) on phenyl ephrine (PE) induced. PE contracted aorta was then studied and the EC50 and maximal relaxant effect of Ach were calculated and compared in the two groups. Results: In the
Diabetes leads to widespread complications including pancreatic β-cell damage, nephropathy and impaired wound healing. Hyperbaric oxygen therapy (HBOT) has been shown to improve wound healing through induction of stem cell recruitment and the potential to inhibit progression of diabetic complications. We aimed to determine the efficacy of HBOT in wound healing and organ preservation in a diabetic rat model. Diabetes was induced in male Wistar rats (n = 10/group) using streptozotocin (20 mg/kg sc) daily for 3 days. A wound was inflicted on the skin over the back and the rats were given HBOT (2.3 ATA for 1 h/day) for 1, 3, 5, 7 or 10 days or were not treated. Blood glucose, pancreatic β-cell damage, diabetic nephropathy and wound healing progression were assessed. Diabetic rats not treated with HBOT had significantly higher blood glucose levels compared to controls (26.7 ± 3.3 mmol/L vs. 5.8 ± 0.4 mmol/L; P ≤ 0.05). This was associated with significant increase in the percentage of β-cell damage
Introduction In the treatment of patients with diabetes, one objective is an improvement of cardiac metabolism to alleviate the left ventricular (LV) function. For this study, we compared the effects of acetyl-l-carnitine (one of the carnitine derivatives) and of oxfenicine (a carnitine palmitoyltransferase-1 inhibitor) on cardiac pumping mechanics in streptozotocin-induced diabetes in male Wistar rats, with a particular focus on the pressure-flow-volume relationship. Methods Diabetes was induced by a single tail vein injection of 55 mg kg−1 streptozotocin. The diabetic animals were treated on a daily basis with either acetyl-L-carnitine (1 g L−1 in drinking water) or oxfenicine (150 mg kg−1 by oral gavage) for 8 wk. They were also compared with untreated age-matched diabetic controls. LV pressure and ascending aortic flow signals were recorded to calculate the maximal systolic elastance (E max) and the theoretical maximum flow (Q max).
Background: Nowadays, the use of L-carnitine in the treatment of diabetes is increasing. This study was conducted to investigate the effect of co-administration of L-arginine (precursor for the synthesis of nitric oxide) and nitro-L-arginine (nitric oxide synthesis inhibitor) on antidiabetic activity of L-carnitine in diabetic rats. Materials and Methods: In this study, 50 male rats weighing 180-201g were divided into five groups: (1) non diabetic control rats; (2) untreated diabetic rats; (3) diabetic rats treated with L-carnitine 300 mg/kg (4); diabetic rats treated with L-carnitine 300 mg/kg + L-arginine 300 mg/kg; and (5) diabetic rats treated with L-carnitine (300 mg/kg) + nitro-L-arginine (1mg/kg). Type 1 diabetes was induced by a single intraperitoneal injection of 110 mg/kg body weight alloxan. After 30 days, liver malondialdehyde levels, lipid profile, serum glucose, and glycated hemoglobin serum levels were measured. Results: Blood glucose, liver enzymes, glycated hemoglobin, and liver ...
There were 54 patients with diabetes type 2 and 36 non-diabetic. Individuals of two groups of obese and non-obese compared with apparently healthy control. Before the body mass index (kg/m2) had been calculated, weight (kg) and height (m) were measured as a normal weight (18.49-24.99 kg/m2), or obese (, 30kg/m2) according to the WHO classification. Adipolin significantly decreased in obese diabetic patients compared with obese controls and it is low in the obese diabetic patients group compared to the nonobese patients group. TAC was significantly increased in the patients compared with controls (p , 0.05) and it was low level in obese diabetic patients compared with nonobese patients group, while MAD was high level in obese diabetic patients compared with nonobese patients group. The study also found weak negative correlated with MDA (r=-0.29, p= 0.13), TAC (r=-0.023, p=0.9), in obese diabetic patients while found weak positive correlated with MDA (r=0.037, p=0.85), TAC (r=0.35, p=0.69) in ...
Wohlrab F.; Schmidt S.; Wilke B.; Cossel L., 1987: Proliferation of b cells in pancreatic islet syngeneic transplantation into the spleen of streptozotocin diabetic lewis rats
Citation: Anderson, R.A., Striffler, J. 2008. Development of a Streptozotocin-induced Diabetic Rat Model for Studies on the Effects of Cinnamon on Glucose Tolerance and Insulin Secretion. Journal of Federation of American Societies for Experimental Biology. 22:1113.6. Interpretive Summary: Technical Abstract: A streptozotocin (STZ) dose response protocol using graded doses of STZ was utilized to develop a diabetic rat model. In addition to the presence of severe basal hyperglycemia, insulin responses to oral glucose showed no change from basal in rats given more than 45 mg of STZ/kg body wt. Oral glucose tolerance (OGT) in rats given 40 mg of STZ/kg body wt was abnormal but the pancreas was able to secrete significant amounts of insulin. In contrast, there was hyper-secretion of insulin associated with near normalization of glucose tolerance at STZ doses of 20 mg/kg body wt or less. In light of these observations, effects of cinnamon dosing on OGT was characterized in rats made diabetic with 40 ...
Hearts from normal and alloxan diabetic rats were perfused in vitro with a bicarbonate-buffered medium containing glucose. Transport of glucose through the cell membrane was stimulated with insulin or by induction of anaerobiosis. The organs were rapidly fixed and examined by electron microscopy. Transport stimulation was not associated with any increase in the number of sarcolemmal invaginations or subsarcolemmal cytoplasmic vesicles. It was concluded that glucose transport and the effects of insulin or anoxia do not involve pinocytosis. The relationship of pinocytosis to glucose transport is discussed. The appearance of numerous lipid inclusions at the Z line level of the sarcomeres in the diabetic and anoxic myocardia is described. ...
In the present study, we investigated the mechanism(s) for glucose-lowering action of andrographolide in streptozotocin-induced diabetic rats (STZ-diabetic rats). Andrographolide lowered plasma glucose concentrations in a dose-dependent manner and increased plasma β-endorphin-like immunoreactivity (BER) dose-dependently in diabetic rats. Both of these responses to andrographolide were abolished by the pretreatment of animals with prazosin or N-(2 -(2-cyclopropylmethoxy) ethyl) 5-choro-α-dimethyl-1H-indole-3-thylamine (RS17053) at doses sufficient to block α1-adrenoceptors (ARs). Also, andrographolide enhanced BER release from isolated rat adrenal medulla in a concentration-related manner that could be abolished by α1-ARs antagonists. Bilateral adrenalectomy in STZ-diabetic rats eliminated the activities of andrographolide, including the plasma glucose-lowering effect and the plasma BER-elevating effect. Andrographolide failed to lower plasma glucose in the presence of opioid μ-receptor ...
OBJECTIVE: To investigate the influences of exercise on the levels of chemerin and its receptor chemokine-like receptor (CMKLR1) in the peripheral metabolic organs of obesity and diabetes rats, and whether the mechanism is related to peroxisome proliferator activated receptor γ (PPARγ), a key modulator of glycolipid metabolism. METHODS: Obesity rats induced by 8-week high fat diet (HFD) were randomly divided into obesity group (OB) and exercised obesity group (EOB) with 8 rats each group, and 40 diabetes rats established by 8-week HFD plus low dose of streptozotocin were randomly divided into 4 groups: diabetes group (DM), exercised diabetes group (EDM), exercised diabetes plus PPARγ agonist pioglitazone group (EDP), and exercised diabetes plus PPARγ antagonist GW9662 group (EDG). The rats in EOB, EDM, EDG and EDP groups participated in a 4-week moderate-intensity aerobic exercise on a treadmill with gradually increasing intensity, once a day and 6 days/week, and 30 min before each exercise ...
Intraperitoneal islet transplantation has the potential to ameliorate type 1 diabetes mellitus and avert the long-term consequences of chronic diabetes which cannot be achieved by conventional insulin treatment.. As donor human islets are not available in sufficient numbers, porcine islets are the best alternative source as they are recognised as the most physiologically compatible xenogeneic insulin-producing cells. Although the use of pig-derived cells raises the risk of xenotic infections, this can be minimised by obtaining cells from designated pathogen-free (DPF) animals bred in isolation and monitored to be free of specified pathogens. The worldwide experience to date in more than 200 patients who have received transplants of pig tissue has not demonstrated evidence of transmitted xenotic infections.. As animal-derived tissues have to be protected from immune rejection when transplanted into humans, transplants are usually accompanied by immunosuppressive therapy. However, porcine islets ...
Negative consequences of diabetes on the prostate such as involution are associated with diminished testosterone, insulin deficiency, and hyperglycemia. The contributions of oxidative damage, which usually increases with diabetes, are unknown for these alterations. This study evaluated the impact of streptozotocin-induced diabetes on the biomarkers of the antioxidant system of rat ventral prostate, the influence of vitamin C supplementation on these biomarkers, and on the balance between cell proliferation and death. Diabetes (D) was induced in Wistar male rats by streptozotocin (5?mg/100?g b.w., i.p.). Control animals (C) were injected with a vehicle. Vitamin C (150?mg/kg b.w./day) supplementation was introduced by gavage in diabetes (D?+?V) as well as control (C?+?V) groups. Thirty days after diabetes onset, the rats were killed and the ventral prostates were analyzed using light microscopy, immunocytochemistry, and biochemical assays for biomarkers of oxidative stress. In comparison to ...
The diabetic mice tended to have greater hematoma expansion than non-diabetic mice, which was as expected from this model of type 1 diabetes.. Injecting the PK inhibitor into diabetic rats resulted in a smaller hematoma spread. In diabetic mice that were engineered to not make the PK protein, hematoma expansion was lower than in diabetic mice that did make this protein.. To see whether the effects on hematoma expansion were dependent on high blood glucose levels (as found in diabetics), diabetic mice were injected with insulin to lower their blood glucose, before they were injected with PK. The large hematoma expansion that would have normally happened in these mice did not occur. In case the process of making the rats diabetic had affected their PK activity rather than the high glucose, the researchers injected non-diabetic rats with glucose to produce a spike of glucose in their blood stream. The hematoma expansion in these hyperglycaemic rats was found to be greater than in the control ...
Streptozotocin-induced diabetes has previously been shown to alter the sensitivity and responsiveness of rat myocardial tissues to cardiotonic agonists. The objective of the present study was to determine if these alterations were due to the diabetogenic or possible direct cardiotoxic effects of streptozotocin. One month after streptozotocin treatment the following changes were observed in the rat: decrease in body weight; elevation of blood glucose and glycosylated hemoglobin levels; decrease in spontaneously beating atrial rate; elevation in basal developed force of electrically driven right ventricle; and inotropic subsensitivity of right ventricle to isoproterenol, which was associated with decreased beta-adrenoceptor density and supersensitivity to calcium. Pretreatment with the nonmetabolizable glucose analog 3-O-methyl glucose prevented these alterations. Chronic insulin replenishment also reversed the effects of streptozotocin, with the exception of complete normalization of elevations in blood
Background and purpose: Okra plant has different properties and some studies reported that this plant can lower the complications of diabetes. Herein, we studied the effects of okra powder on histomorphometry and histochemitry of the thyroid gland, lipid profile, as well as T3 and T4 hormones in HDF/STZ diabetic Wistar ...
Lunardi N, Ori C, Erisir A, Jevtovic-Todorovic V. General anesthesia causes long-lasting disturbances in the ultrastructural properties of developing synapses in young rats. Neurotoxicology Research 2010;17:179-88.. Messinger RB, Naik AK, Jagodic MM, Nelson MT, Lee WY, Choe WJ, Orestes P, Latham JR, Todorovic SM, Jevtovic-Todorovic V. In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy. Pain 2009;145:184-95.. Latham JR, Pathirathna S, Jagodic MM, Levin ME, Nelson MT, Lee WY, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Selective T-type calcium channel blockade alleviates hyperalgesia of morbid-obesity-induced diabetic neuropathy in ob/ob mice. Diabetes 2009;58:2656-65.. Rizzi S, Carter LB, Ori C, Jevtovic-Todorovic V. Clinical anesthesia causes permanent damage to the fetal guinea pig brain. Brain Pathology 2008;18(2):198-210.. Yon, J-H, Carter LB, Reiter RJ, Jevtovic-Todorovic V. ...
"Telemedicine and ocular health in diabetes mellitus". Clinical and Experimental Optometry. 95 (3): 311-327. doi:10.1111/j.1444- ... Since 2001, more than 30,000 people with diabetes have been screened since 2001 as part of a project called EyeCheck in the ... In the United Kingdom, more than 1.7 million people with diabetes were screened using digital fundus photography in 2010 and ...
Hypoglycemic effect of disulfides in experimental diabetes mellitus. Anti-atherosclerotic effect of disulphide in rats fed ...
Among his professional research interests was diabetes mellitus. His appointments included one as Professor of Experimental ...
It is an experimental treatment for type 1 diabetes mellitus. Once transplanted, the islets begin to produce insulin, actively ... Health Quality Ontario (2015). "Pancreas Islet Transplantation for Patients With Type 1 Diabetes Mellitus: A Clinical Evidence ... "Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen". ... "Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia". Diabetes Care. 39 (7 ...
"Treatment of diabetes mellitus by Artemisia herba-alba extract: preliminary study". Clinical and Experimental Pharmacology & ... Artemisia herba-alba based teas were used in Iraqi folk medicine for the treatment of diabetes mellitus. An aqueous extract of ...
Drachman RH, Root RK, Wood WB (August 1966). "Studies on the effect of experimental nonketotic diabetes mellitus on ... Like NOD mice, biobreeding rats are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features ... The biobreeding rat (a.k.a. the biobreeding diabetes-prone rat or BBDP rat) is an inbred strain that spontaneously develops ... Mordes JP, Bortell R, Blankenhorn EP, Rossini AA, Greiner DL (1 January 2004). "Rat models of type 1 diabetes: genetics, ...
"Morphological Restructuring of Myocardium During the Early Phase of Experimental Diabetes Mellitus". Anat. Rec. 298 (2): 396- ... This causes an insulin-dependent diabetes mellitus (called "alloxan diabetes") in these animals, with characteristics similar ... "Blood Levels of Alloxan in Children with Insulin-dependent Diabetes Mellitus". Acta Diabetologica. 31 (4): 236-237. doi:10.1007 ... Experimental surgical models in the laboratory rat. Boca Raton: CRC Press. Szkudelski T (2001). "The mechanism of alloxan and ...
... is an experimental drug for the treatment of type 2 diabetes mellitus. It lowers blood glucose levels by mimicking ... Diabetes, Obesity & Metabolism. 18 (12): 1176-1190. doi:10.1111/dom.12735. PMC 5129521. PMID 27377054. "Cotadutide". ...
"Increased Plasma Levels of Nesfatin-1 in Patients with Newly Diagnosed Type 2 Diabetes Mellitus". Experimental and Clinical ... In previous studies, we have also shown that plasma nesfatin-1 levels were elevated in patients with type 2 diabetes mellitus ( ... Diabetes. 61 (8): 1959-68. doi:10.2337/db11-1755. PMC 3402309. PMID 22688332. Stengel, A.; Goebel, M.; Wang, L.; Rivier, J.; ... Diabetes Ghrelin Insulin Leptin Nucleobindin-2 Obestatin Oh-i, Shinsuke; Shimizu, Hiroyuki; Satoh, Tetsurou; Okada, Shuichi; ...
Evaluation Of The Anti-Diabetic Properties Of Averrhoa bilimbi in Animals with Experimental Diabetes Mellitus (PDF). National ...
Purnell JQ, Weyer C (2003). "Weight effect of current and experimental drugs for diabetes mellitus: from promotion to ... Hermansen K, Mortensen LS (2007). "Bodyweight changes associated with antihyperglycaemic agents in type 2 diabetes mellitus". ...
Diabetes mellitus and vascular disease. Postgrad Med J 1973; 53: 54-59. Bloodworth JM Jr: Diabetic retinopathy. Diabetes 1962; ... the American Diabetes Association, the Society for Experimental Biology and Medicine, and the American Society of Clinical ... Together with his colleagues, he focused on the causes and prevention of microangiopathy in diabetes mellitus. In particular, ... Bloodworth JM Jr: Renal vascular disease associated with diabetes mellitus. Minn Med 1967; 50: 335-340. Bloodworth JM Jr, ...
"Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus". Experimental and ... Serum FGF-21 levels were significantly increased in patients with type 2 diabetes mellitus (T2DM) which may indicate a role in ... Diabetes. 63 (12): 4057-63. doi:10.2337/db14-0595. PMC 4238010. PMID 25008183. Grabacka M, Pierzchalska M, Dean M, Reiss K ( ... Clinical Endocrinology & Diabetes. 116 (1): 65-8. doi:10.1055/s-2007-985148. PMID 17926232. Kharitonenkov A, Wroblewski VJ, ...
... and indications are that it might be useful in combatting diabetes mellitus. In folk medicine, tea has been brewed from the ... Indian Journal of Experimental Biology. 36 (1998): 426-428. Nellis, David W. Poisonous Plants and Animals of Florida and the ... "Hemagglutination Pattern of Galactose Specific Lectin From Pedilanthus tithymaloides in Diabetes Mellitus," Indian Journal of ... "Hemagglutination Pattern of Galactose Specific Lectin From Pedilanthus tithymaloides in Diabetes Mellitus." ...
It was designed to improve self-care behavior in children with Diabetes mellitus type 1. The game achieved some success with ... It is a part of educational video game series from Raya that includes Captain Novolin, Rex Ronan: Experimental Surgeon and ... A three-month study found that for kids with diabetes, the game "decreased their diabetes-related emergency room and urgent ... "Packy and Marlon was designed to help remove the stigma of being different so young people with diabetes who played the game ...
The main research focus is the elucidation of genetic and epigenetic factors of diabetes mellitus. Hrabĕ de Angelis was co- ... In 2003 he was appointed to the Chair of Experimental Genetics at Technische Universität München. At the same time, he is ... He is co-founder, speaker and board member of the German Center for Diabetes Research (DZD). His research focuses on metabolism ... Using a mouse model, Hrabĕ de Angelis has shown that dietary obesity and diabetes can be epigenetically inherited to offspring ...
In 1919, Julius Elster was diagnosed with a disease (diabetes mellitus). In April 1920, the Privy Councilor Julius Elster died ... in Wolfenbüttel and used their leisure for experimental research. There Karl Bergwitz (1875-1958) was among their students. ...
Boca Raton, CRC Press, 2007 Colle, E., R.D. Guttmann, and T. Seemayer, Spontaneous diabetes mellitus syndrome in the rat. I. ... The Journal of experimental medicine, 1981. 154(4): p. 1237-42. Poussier, P., et al., Lymphopenia and abnormal lymphocyte ... Diabetes. 2009 Apr;58(4):1007-17. Epub 2009 Jan 23 Mordes, J.P., et al., Rat models of type 1 diabetes: genetics, environment, ... NOD mice Type 1 Diabetes Autoimmunity Mordes JP, Poussier P, Blankenhorn EP, Greiner DL: Rat models of type 1 diabetes: ...
"Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus - ... Metabolism - Clinical and Experimental". www.metabolismjournal.com. Retrieved 16 June 2015. Shehzad, Saima (1 January 2013). " ... It has been shown that starvation and diabetes induces a two- to threefold increase in glucose 6-phosphatase activity in the ... the beta cell antigenic sequence that is targeted in diabetes is not responsible for the loss of phosphohydrolase activity". ...
"Susceptibility and resistance genes to insulin-dependent diabetes mellitus in the BB rat". Experimental and Clinical ... Enhanced MHC class I heavy-chain gene expression in pancreatic islets". Diabetes. 37 (10): 1411-8. doi:10.2337/diabetes.37.10. ... Diabetes. 38 (7): 911-6. doi:10.2337/diabetes.38.7.911. PMID 2544472. Colle E; Ono SJ; Fuks A; Guttmann RD; Seemayer TA ( ... Diabetes. 37 (10): 1438-43. doi:10.2337/diabetes.37.10.1438. PMID 2901375. Ono SJ; Fuks A; Guttmann RD; Colle E (1989). " ...
"Prevention of glomerular basement membrane thickening by aminoguanidine in experimental diabetes mellitus". Metabolism. 40 (10 ... Araki A (September 1997). "[Oxidative stress and diabetes mellitus: a possible role of alpha-dicarbonyl compounds in free ... Women with pre-existing diabetes or severe diabetes that develops during pregnancy are between 3 and 4 times more likely than ... Diabetes. 43 (9): 1152-6. doi:10.2337/diabetes.43.9.1152. PMID 8070616. Kappler F, Schwartz ML, Su B, Tobia AM, Brown T (2001 ...
Insulin sensitising action of chromium picolinate in various experimental models of diabetes mellitus. J Trace Elem Med Biol 18 ... 5] studied the effects of chromium treatment in a group of Chinese patients with type 2 diabetes. They reported an average ... both in nondiabetic healthy subjects and in patients with type 2 diabetes. 2. Shindea UA, Sharma G, Xu YJ, Dhalla NS, Goyal RK ...
"MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus ... The Journal of Experimental Medicine. 207 (7): 1351-8. doi:10.1084/jem.20100458. PMC 2901075. PMID 20513743. Karolina DS, ...
"Morphological restructuring of myocardium during the early phase of experimental diabetes mellitus" (PDF). Anatomical Record. ... Type 1 diabetes mellitus, also known as insulin dependent diabetes, is believed to be caused by an auto-immune mediated ... Type 2 diabetes mellitus, also known as non insulin dependent diabetes and as chronic hyperglycemia, is caused primarily by ... U.K. Prospective Diabetes Study Group". Diabetes. 44 (11): 1249-58. November 1995. doi:10.2337/diabetes.44.11.1249. PMID ...
PPARγ (gamma) is the main target of the drug class of thiazolidinediones (TZDs), used in diabetes mellitus and other diseases ... These include the experimental compounds aleglitazar, muraglitazar and tesaglitazar. In June 2013, saroglitazar was the first ... Diabetes. 54 (8): 2460-70. doi:10.2337/diabetes.54.8.2460. PMID 16046315. Nevin DK, Fayne D, Lloyd DG (2011). "Rational ... Fiévet C, Fruchart JC, Staels B (2006). "PPARalpha and PPARgamma dual agonists for the treatment of type 2 diabetes and the ...
"The effect of MCI-9042 on serotonin-induced platelet aggregation in type 2 diabetes mellitus". Thrombosis Research. 70 (2): 131 ... Clinical and Experimental Pharmacology & Physiology. 26 (5-6): 461-4. doi:10.1111/j.1440-1681.1999.03056.x. PMID 10386239. ... and has applications in the treatment of many diseases including diabetes mellitus, Buerger's disease, Raynaud's disease, ... reduces urinary and plasma levels of thromboxane A2 and urinary albumin excretion in non-insulin-dependent diabetes mellitus ...
A missense mutation at 17q25 in the GCGR gene is associated with diabetes mellitus type 2. Inactivating mutation of glucagon ... and the G-protein C-terminus has been determined using a computational and experimental approach. ... "Role of the Gly40Ser mutation in the glucagon receptor gene in Brazilian patients with type 2 diabetes mellitus". Pancreas. 24 ... "A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus". Nature Genetics ...
The status of the coronary collaterals has also been shown to be influenced by the presence of diabetes mellitus. The ... functional significance of the coronary collateral vessels is a matter of continuing experimental investigation although their ...
The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late ... Experimental investigations on TZDs have been carried out since 2005 in polycystic ovary syndrome (PCOS), non-alcoholic ... The only approved use of the thiazolidinediones is in diabetes mellitus type 2. According to a 2014 Cochrane systematic review ... Feng L, Karakiulakis G, Roth M (11 March 2020). "Are patients with hypertension and diabetes mellitus at increased risk for ...
... sign of impaired thrombopoiesis in diabetes mellitus". Klinische Wochenschrift. 67 (4): 253-9. doi:10.1007/BF01717328. PMID ... Experimental Hematology. 13 (2): 143-50. PMID 2857651. Perron M, Boy S, Amato MA, et al. (April 2003). "A novel function for ... Diabetes. 53 (8): 2143-52. doi:10.2337/diabetes.53.8.2143. PMID 15277399. Bucchini D, Lasserre C, Kunst F, Lovell-Badge R, ...
... discusses how simple polygenic inheritance cannot explain some diseases such as the onset of Type I diabetes mellitus, and that ... Family based QTL mapping has been the only way for mapping of genes where experimental crosses are difficult to make. However, ... Many disorders with genetic components are polygenic, including autism, cancer, diabetes and numerous others. Most phenotypic ... Interval mapping is currently the most popular approach for QTL mapping in experimental crosses. The method makes use of a ...
diabetes mellitus[8]. *erectile dysfunction. DiagnosisEdit. Diagnosis is made first by diagnosing Cushing's syndrome, which can ... Experimental evidence and case reports by Cushing led to his publication in 1932 on pituitary basophilism as the cause of ... Diabetes insipidus (15%), fluid and electrolyte abnormalities (12.5%), and neurological deficits (5.6%) were the most common ...
... following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus". ... Clinical and Experimental Rheumatology. 34 (4 Suppl 98): 53-57. ISSN 0392-856X. PMID 27586805.. ... diabetes in children and adults. Results have been promising; however, as of 2009[update] it was premature to speculate whether ... these experiments will lead to effective treatments for diabetes.[19] Allogeneic[edit]. Allogeneic HSCT involves two people: ...
Polyuria, abnormally large production of urine, associated with, in particular, diabetes mellitus (types 1 and 2), and diabetes ... When the sacral dorsal roots are cut in experimental animals or interrupted by diseases of the dorsal roots such as tabes ...
Ditzel, Jørn (1967-01-12). "The in Vivo Reactions of the Small Blood Vessels to Diabetes Mellitus". Acta Medica Scandinavica ( ... Experimental Ophthalmology. 37 (4): 335-344. doi:10.1111/j.1442-9071.2009.02065.x. ISSN 1442-9071. PMID 19594558.. ... Isenberg, S. J.; McRee, W. E.; Jedrzynski, M. S. (1986-10-01). "Conjunctival hypoxia in diabetes mellitus". Investigative ... "Microvascular abnormalities in the bulbar conjunctiva of patients with type 2 diabetes mellitus". Endocrine Practice. 7 (5): ...
... diabetes mellitus (DM) - diagnosis - diarrhea - diplopia - dissemination - division of acquired immunodeficiency syndrome ( ... experimental drug - expression system ...
... diabetes mellitus, muscle wasting, osteoporosis, lung cancer, anxiety disorder, sexual dysfunction, and depression.[2][39] In ... Experimental Lung Research. 39 (8): 315-27. doi:10.3109/01902148.2013.816803. PMID 23992090. S2CID 46052894.. ...
... therapy has furthermore proven effective against genital warts in experimental use, but is rarely used for this ... Diabetes mellitus. *Hyperuricaemia. Psychiatric *Depression. *Aggravated depression. *Aggressive tendencies. *Anxiety. *Mood ... Experimental Dermatology. 11 (3): 241-7. doi:10.1034/j.1600-0625.2002.110307.x. PMID 12102663.. ...
Definition of a subtype of diabetes mellitus". 》The New England Journal of Medicine》 328 (10): 697-702. doi:10.1056/ ... "Clinical and Experimental Gastroenterology》 4: 55-73. doi:10.2147/CEG.S17634. PMC 3132852. PMID 21753892.. ...
... i diabetes mellitus (koji potrostručuje opasnost)[35] Sve važniji čimbenici rizika, osobito u razvijenim zemljama postaju i ... Bonah C (2005). "The 'experimental stable' of the BCG vaccine: safety, efficacy, proof, and standards, 1921-1933". Stud Hist ... "Convergence of the tuberculosis and diabetes epidemics: renewal of old acquaintances". Clinical infectious diseases: an ...
... excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 diabetes mellitus". ... Clinical and Experimental Research. 20 (9): 1512-7. doi:10.1111/j.1530-0277.1996.tb01692.x. PMID 8986196.. ...
2009). "Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual ... "Tetradecylthioacetic Acid Attenuates Inflammation and Has Antioxidative Potential During Experimental Colitis in Rats". ... and another showed that TTA attenuates dyslipidemia in patients with type 2 diabetes mellitus.[1] ... PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation". Diabetes, Obesity & Metabolism. 11 (4): 304-14. ...
Elliott Proctor Joslin; C. Ronald Kahn (2005). Joslin's Diabetes Mellitus: Edited by C. Ronald Kahn ... [et Al.]. Lippincott ... "Apomorphine: from experimental tool to therpeutic aid" (PDF). In Ban, Thomas A; Healy, David & Shorter, Edward. The Triumph of ...
Diabetes mellitus[sunting , sunting sumber]. Berdasarkan studi hasil otopsi, penderita diabetes mellitus rentan terhadap infark ... "Department of Experimental Neurology Charité, Humboldt University; Mergenthaler P, Dirnagl U, Meisel A. Diakses tanggal 2011-07 ... "Diabetes mellitus and cerebrovascular disease". Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical ... Tidak ditemukan korelasi antara leukoaraiosis dengan diabetes mellitus, hiperlipidemia, merokok, hipertensi dan penyakit ...
Zvýšení tělesné hmotnosti riziko snižuje.[87] Lidé s diabetes mellitus mají zvýšené riziko rozvoje tuberkulózy[88] a hůře ... Bonah, C. The 'experimental stable' of the BCG vaccine: safety, efficacy, proof, and standards, 1921-1933. Studies in History ... Dooley, K. E., Chaisson, R. E. Tuberculosis and diabetes mellitus: convergence of two epidemics. The Lancet Infectious Diseases ... Jeon, C. Y., Murray, M. B. Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational ...
"A systematic review of vanadium oral supplements for glycaemic control in type 2 diabetes mellitus". QJM. 101 (5): 351-358. doi ... Vanadyl sulfate is a component of food supplements and experimental drugs. Vanadyl sulfate exhibits insulin-like effects.[11] ... Vanadyl sulfate has been extensively studied in the field of diabetes research as a potential means of increasing insulin ... "Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes". Diabetes Care. 26 (4): 1277-1294. doi ...
... hemoglobin are therefore measured in order to monitor the long-term control of the chronic disease of type 2 diabetes mellitus ... Assigning oxygenated hemoglobin's oxidation state is difficult because oxyhemoglobin (Hb-O2), by experimental measurement, is ... Society for Biomedical Diabetes Research. SI Unit Conversion Calculator. *^ Handin, Robert I.; Lux, Samuel E. and StosselBlood ... The Journal of Experimental Biology. 209 (Pt 10): 1791-802. doi:10.1242/jeb.02091. PMID 16651546.. ...
"Hepatocyte growth factor as a potential index of complication in diabetes mellitus". Journal of Hypertension. 16 (12 Pt 2): ... "The Journal of Pharmacology and Experimental Therapeutics. 351 (2): 390-402. doi:10.1124/jpet.114.218735. PMC 4201273. PMID ...
Autoimmune diseases typically associated with celiac disease are diabetes mellitus type 1, thyroiditis, gluten ataxia, ... Journal of Experimental Medicine. 209 (13): 2395-2408. doi:10.1084/jem.20102660. ISSN 0022-1007. PMC 3526354 . PMID 23209313. ... Journal of Experimental Medicine. 209 (13): 2395-2408. doi:10.1084/jem.20102660. ISSN 0022-1007. PMC 3526354 . PMID 23209313. ... but this technology is not yet generally available and remains as an experimental procedure. Evaluating the presence of ...
There is usually a granulocyte chemotactic defect in individuals suffering from insulin-dependent diabetes mellitus. ... "Clinical & Experimental Immunology. 151 (1): 139-45. doi:10.1111/j.1365-2249.2007.03532.x. PMC 2276935 . PMID 17991288.. ... "Clinical & Experimental Allergy. 38 (8): 1254-63. doi:10.1111/j.1365-2222.2008.03037.x. PMC 2735457 . PMID 18727793.. ...
A sedentary lifestyle increases the risk factors associated with AF, such as obesity, hypertension, or diabetes mellitus. This ... This process occurs gradually, and experimental studies have revealed patchy atrial fibrosis may precede the occurrence of ... diabetes mellitus, and thyrotoxicosis.[3][7][14] However, half of the cases are not associated with any of these risks.[3] ... diabetes mellitus, or hypertension without specific blood sugar or blood pressure targets for people with atrial fibrillation.[ ...
Both hypertension and diabetes mellitus can cause damage to the tiny blood vessels that supply the retina, leading to ... "Experimental Eye Research. 13 (1): 92-97. doi:10.1016/0014-4835(72)90129-7. PMID 5060117. Archived from the original on 9 ... Experimental Eye Research. 86 (4): 691-700. doi:10.1016/j.exer.2008.01.018. PMID 18329018.. ...
Endocrinologic: Diabetes mellitus type 1, Hashimoto's thyroiditis, Addison's disease. *Gastrointestinal: Coeliac disease, ... Helminthic therapy is an experimental approach that involves inoculation of the patient with specific parasitic intestinal ... HLA DR4 is correlated with the genesis of rheumatoid arthritis, Type 1 diabetes mellitus, and pemphigus vulgaris. ... type 1 diabetes mellitus, granulomatosis with polyangiitis, Crohn's disease, Primary sclerosing cholangitis and psoriasis. ...
Kurkumin se pokazao veoma dobrim u lečenju diabetes mellitus. U raznim kliničkim ispitivanjima kurkumin popravio stanje kod ... Kolev, Tsonko M.; Velcheva, Evelina A.; Stamboliyska, Bistra A.; Spiteller, Michael (2005). „DFT and experimental studies of ...
Diabetes mellitus type 1. *Hashimoto's thyroiditis. *Multiple sclerosis. *Coeliac disease. *Giant-cell arteritis ... Experimental Allergy. 32 (3): 448-54. doi:10.1046/j.1365-2222.2002.01306.x. PMID 11940077.. ...
Davì G, Falco A, Patrono C (2005). "Lipid peroxidation in diabetes mellitus". Antioxidants & Redox Signaling. 7 (1-2): 256-68. ... Advances in Experimental Medicine and Biology. 459. pp. 23-50. doi:10.1007/978-1-4615-4853-9_3. ISBN 978-0-306-46051-7. PMID ... Krieger-Liszkay A (January 2005). "Singlet oxygen production in photosynthesis". Journal of Experimental Botany. 56 (411): 337- ... Giugliano D, Ceriello A, Paolisso G (March 1996). "Oxidative stress and diabetic vascular complications". Diabetes Care. 19 (3 ...
... diabetes mellitus type 1, hypothyroidism, primary biliary cholangitis, microscopic colitis, gluten ataxia, psoriasis, vitiligo ... "Clinical and Experimental Gastroenterology (Review). 9: 225-36. doi:10.2147/ceg.s87200. PMC 4976763 . PMID 27536154.. ... such as diabetes mellitus type 1 and thyroiditis, among others.[6] ... "National Institute of Diabetes and Digestive and Kidney Diseases. June 2016. Archived from the original on 24 April 2017. ...
"Association of sleep time with diabetes mellitus and impaired glucose tolerance". Arch. Intern. Med. 165 (8): 863-7. doi: ... "Boy, 3, Sleeps for First Time After Experimental Surgery". FoxNews.com. 16 May 2008. Archived from the original on 5 October ... Type 2 diabetes[edit]. It has been suggested that people experiencing short-term sleep restrictions process glucose more slowly ... The authors point to an earlier study which showed that experimental rather than habitual restriction of sleep resulted in ...
... diabetes mellitus, cardiovascular disease, during delivery if maternal blood pressure is ,130/80 mmHg, and during lactation.[21 ... The Journal of Pharmacology and Experimental Therapeutics. 148 (2): 158-68. PMID 14301006.. ...
"Dose-Response Relationship between Dietary Magnesium Intake and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta- ... 1 μM and does not vary with the experimental conditions under which Mg2+ is to be measured. Recently, Otten et al. (2001) have ... Diabetes and glucose toleranceEdit. Higher dietary intakes of magnesium correspond to lower diabetes incidence.[15] For people ... Inadequate magnesium intake frequently causes muscle spasms, and has been associated with cardiovascular disease, diabetes, ...
The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, ... and clinical studies related to type 1 and type 2 diabetes. ... Journal of Diabetes Research is a peer-reviewed, Open Access ... The two most common types of diabetes mellitus are type 1 diabetes (T1D) and type 2 diabetes (T2D). Type 1 diabetes is ... A number of studies with STZ-induced diabetes mellitus reported that diabetes mellitus can improve the recovery of cardiac ...
Glycation of rat sciatic nerve tubulin in experimental diabetes mellitus.. Cullum NA1, Mahon J, Stringer K, McLean WG. ... The observed glycation of peripheral nerve tubulin in early experimental diabetes may nevertheless contribute to axonal ... As lysine residues are the major target for the non-enzymatic attachment of glucose, the effect of diabetes on the extent of ... Diabetic neuropathy is associated with some early defects of axonal transport in experimental animals. Axonal transport is ...
Experimental from related diseases, pathways, genes and PTMs with the Novus Bioinformatics Tool. ... Research of Diabetes Mellitus, Experimental has been linked to Diabetes Mellitus, Hyperglycemia, Diabetes Mellitus, Insulin- ... Diabetes Mellitus, Experimental has been studied in relation to diseases such as: *Diabetes Mellitus ... Diabetes Mellitus, Non-insulin-dependent, Diabetic Nephropathy. The study of Diabetes Mellitus, Experimental has been mentioned ...
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. ... Experimental Diabetes Mellitus. Subscribe to New Research on Experimental Diabetes Mellitus Diabetes mellitus induced ... Diabetes Mellitus, Experimental; Diabete, Streptozocin; Diabetes, Alloxan; Diabetes, Streptozocin; Diabetes, Streptozotocin; ... related to Experimental Diabetes Mellitus: 1. Insulin (Novolin)FDA Link 02/01/1983 - "Induction of streptozotocin-diabetes in ...
Uncoupling Endothelial Nitric Oxide Synthase Is Ameliorated by Green Tea in Experimental Diabetes Mellitus by Re-Establishing ... 2017 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X. ...
Using Type 2 Diabetes Mellitus (T2DM) as a sample complex disease, I show that using combined criteria for differential gene ... Subject(s): Approach, Complex, Computational, Diabetes, Differential Gene Expression, Disease, Experimental, Genetic Linkages, ... An integrated experimental and computational approach to understanding complex disease: Differential gene expression in type 2 ... By definition, complex diseases (e.g. hypertension, diabetes, asthma) demonstrate both environmental and genetic factors in ...
Diabetes Mellitus, Experimental/metabolism[MeSH] - Search Results - PubMed ... The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: experimental and clinical implications ... PURPOSE: Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia. So far, the pathogenesis of diabetes ... PURPOSE: Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia. So far, the pathogenesis of diabe … ...
Effect of KATP Channel Blocker U37883A on Renal Function in Experimental Diabetes Mellitus in Rats Volker Vallon, Margitta ... Effect of KATP Channel Blocker U37883A on Renal Function in Experimental Diabetes Mellitus in Rats Volker Vallon, Margitta ... Effect of KATP Channel Blocker U37883A on Renal Function in Experimental Diabetes Mellitus in Rats Volker Vallon, Margitta ... Effect of KATP Channel Blocker U37883A on Renal Function in Experimental Diabetes Mellitus in Rats ...
We demonstrated the increase in numbers of the leukocytes with both early and late signs of apoptosis at diabetes. Further ... This study is an attempt to elucidate of agmatine effects upon leukocyte apoptosis in experimental diabetes mellitus (EDM). ... This study is an attempt to elucidate of agmatine effects upon leukocyte apoptosis in experimental diabetes mellitus (EDM). We ... Inhibiting Effect of Agmatine on Genetically Programmed Death of Leukocytes in Experimental Diabetes Mellitus [Article in ...
Dissertation: Exploration of Conditions Affecting Cytokine Production in Experimental Type 1 Diabetes Mellitus. ... Exploration of Conditions Affecting Cytokine Production in Experimental Type 1 Diabetes Mellitus. University dissertation from ... Keywords: MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cytokine; Diabetes; Tumor necrosis factor-?; ... Patient Education for People with Type 2 Diabetes in Primary Health Care ...
Type 1 diabetes mellitus (T1DM) is a complex multifactorial disorder which involves a loss of self-tolerance leading to the ... Mesenchymal Stem Cell Therapy in Type 1 Diabetes Mellitus and Its Main Complications: From Experimental Findings to Clinical ... Mesenchymal Stem Cell Therapy in Type 1 Diabetes Mellitus and Its Main Complications: From Experimental Findings to Clinical ... Type 1 diabetes mellitus (T1DM) is a complex multifactorial disorder which involves a loss of self-tolerance leading to the ...
... , Yuji Asai, Hiroyuki ... Influence of Experimental Diabetes Mellitus on Secretary Granules in ß-Cells in the Dog Pancreatic Islet. Yuji Asai1, Hiroyuki ... One was a control group and the other served as those with experimental diabetes mellitus (DM) and received injections of ... Diabetes 1972; 21:1051-1059.. *Chang AY, Diani AR. Chemically and hormonally induced Diabetes Mellitus. In: The Diabetic ...
EFFECT OF WHOLE BODY X-IRRADIATION ON EXPERIMENTAL ENCEPHALOMYOCARDITIS VIRUS INFECTION IN MICE ... Virus-induced diabetes mellitus. XVIII. Inhibition by a nondiabetogenic variant of encephalomyocarditis virus. J W Yoon , J W ... J W Yoon, P R McClintock, T Onodera, A L Notkins; Virus-induced diabetes mellitus. XVIII. Inhibition by a nondiabetogenic ... Virus-induced diabetes mellitus. VI. Genetically determined host differences in the replicating of encephalomyocarditis virus ...
Research in diabetes has accelerated in two areas, both of which are being reviewed in CTMI. The first is the use of a variety ... The Role of Viruses and the Immune System in Diabetes Mellitus. Experimental Models. ... The Role of Class II Molecules in Development of Insulin-Dependent Diabetes Mellitus in Mice, Rats and Humans ... The Spontaneously Diabetic BB Rat: Sites of the Defects Leading to Autoimmunity and Diabetes Mellitus. A Review ...
Insulins biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus. *DOI: ... Experimental Data. *Method: X-RAY DIFFRACTION. *Resolution: 2.30 Å. *R-Value Free: 0.307 ... Insulins biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus. Weiss, M ...
Reference: Kucherenko A.G., Zadkova G.F., Markov Kh.M., Poleshchuk V.S., Renal prostanoids in experimental diabetes mellitus, ... Abstract: Participation of renal prostanoids in development of diabetes-induced nephropathy was studied in rats with ... to formation of diabetic nephropathy in the experimental animals. ... streptozotocin diabetes. Development of diabetic nephropathy occurred with simultaneous decreases in production of intrarenal ...
Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus. In: Journal of Clinical ... Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus. Journal of Clinical ... Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus. / Takayanagi, Ryoichi; ... title = "Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus", ...
Diabetes mellitus is classified into two groups. Type 1 diabetes requires insulin treatment, whereas type 2 diabetes, which is ... This review provides an overview of diabetes mellitus, describes oral therapeutic agents for diabetes and their targets, and ... Therapy of Diabetes Mellitus Using Experimental Animal Models T. S. Min, S. H. Park. DOI : https://doi.org/10.5713/ajas. ... Diabetes mellitus is a worldwide epidemic with high mortality. As concern over this disease rises, the number and value of ...
Experimental Protocol. After a 60-minute equilibration period, the effects of vehicle, BQ-3020 (Calbiochem), and Nω-nitro-l- ... Effects of Hypertension, Diabetes Mellitus, and Hypercholesterolemia on Endothelin Type B Receptor-Mediated Nitric Oxide ... Effects of Hypertension, Diabetes Mellitus, and Hypercholesterolemia on Endothelin Type B Receptor-Mediated Nitric Oxide ... Effects of Hypertension, Diabetes Mellitus, and Hypercholesterolemia on Endothelin Type B Receptor-Mediated Nitric Oxide ...
Animal experimental protocol. At the end of the 32 weeks experimental period, rats were anesthetized with 10% chloral hydrate ... Adiponectin improves coronary no-reflow injury by protecting the endothelium in rats with type 2 diabetes mellitus Xue Han ; ... To determine the effect of adiponectin (APN) on the coronary no-reflow (NR) injury in rats with Type 2 diabetes mellitus (T2DM ... Efficacy of liraglutide in treating type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease Biosci Rep ( ...
Animals and Experimental Model of DM. The study is in accordance with the Ethical Principles in Animal Research adopted by the ... Diabetes mellitus (DM) is an important risk factor for ED. Over 50% of men with DM develop ED.5-7 In humans, DM is associated ... Prevalence of erectile dysfunction among Chinese men with type 2 diabetes mellitus. Int J Impot Res. 2010;22:310-317. doi: ... NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation. 2013;127:1888-1902. doi: ...
Estudo experimental da exposição ao PCB126 sobre a indução de Diabetes mellitus tipo II ... Experimental study of PCB126 exposure on induction of Diabetes mellitus type II. ... à gênese do diabetes mellitus. A caracterização da exposição foi determinada pela quantificação da concentração de PCB126 no ... obesidade e/ou diabetes mellitus, e a presença destes poluentes, principalmente os organoclorados, como as bifenilas ...
Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model ... Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model. ... Administration, Oral , Animals , Diabetes Mellitus, Experimental/chemically induced , Furosemide/administration & dosage , ... Diabetes Mellitus, Experimental / Furosemide / Insulin / Animals Language: English Year: 1993 Type: Article ...
Experimental Details. The Fasting and Postprandial whole blood samples were collected from diabetic patients aged between 15-85 ... Diabetes Care 27: 1047-1053.. *American Diabetes Association(2010) Diagnosis and Classification of Diabetes Mellitus Diabetes ... 2013) Prevalence of diabetes complications inpeople with type 2 diabetes mellitus and its association with ... World Diabetes Foundation(2003) International Diabetes Federation. Diabetes Atlas for 2003 pp2. ...
Diabetes Mellitus, Experimental. Eda Cengiz, MD, MHS, FAAP Associate Professor of Pediatrics (Endocrinology) ... Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies View Full Profile ...
This review will summarize the main experimental and clinical findings obtained with pharmacological IL-1ß inhibitors in the ... In adults, type 2 diabetes mellitus (T2DM) accounts for the majority of all diagnosed cases of diabetes. The course of the T2DM ... In adults, type 2 diabetes mellitus (T2DM) accounts for the majority of all diagnosed cases of diabetes. The course of the T2DM ... This review will summarize the main experimental and clinical findings obtained with pharmacological IL-1ß inhibitors in the ...
Tempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus. Elisa B M I Peixoto, Alexandros ... Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development ... 1 and podocyte loss by apoptosis contribute to albuminuria in diabetes mellitus (DM). In the present study, we investigated the ... SOD mimetic prevents NADPH oxidase-induced oxidative stress and renal damage in the early stage of experimental diabetes and ...
Helping you find trustworthy answers on Nutrition in Diabetes Mellitus , Latest evidence made easy ... Find all the evidence you need on Nutrition in Diabetes Mellitus via the Trip Database. ... 2018 Experimental and therapeutic medicine Controlled trial quality: uncertain * Tweet this. * Star this ... Adult Type 1 diabetes mellitus Adult Type 1 diabetes mellitus Adult type 1 diabetes mellitus National Clinical Guideline No. 17 ...
Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus. Suman Bala Sharma, Afreena ... Fruit of the jambolan tree (Eugenia jambolana Lam.) and experimental diabetes. M T Pepato, D M Mori, A M Baviera, J B Harami, R ... Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts. S S Rathi, J K Grover, Vats Vikrant, N R ... Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals. Rajesh Kumar ...
  • Using Type 2 Diabetes Mellitus (T2DM) as a sample complex disease, I show that using combined criteria for differential gene expression and genetic linkage yields a better selection of candidate genes than using either criterion alone. (umich.edu)
  • People suffering from Type 2 diabetes mellitus (T2DM) were part of the study. (omicsonline.org)
  • In adults, type 2 diabetes mellitus (T2DM) accounts for the majority of all diagnosed cases of diabetes. (frontiersin.org)
  • In adults, the prevalence of type 2 diabetes mellitus (T2DM) is markedly higher that that of type 1 diabetes mellitus (T1DM), since it accounts for at least 90% of all diagnosed cases of diabetes. (frontiersin.org)
  • The purpose of the study is to compare sitagliptin and glipizide in lowering blood sugar in participants with type-2 diabetes mellitus (T2DM) and end-stage renal disease on dialysis who do not have adequate glycemic control. (clinicaltrials.gov)
  • To assess the efficacy and safety of berberine in the treatment of type 2 diabetes mellitus (T2DM). (hindawi.com)
  • Type 2 diabetes mellitus (T2DM) is the most common form of diabetes. (hindawi.com)
  • With the dramatically increasing prevalence of obesity and type 2 diabetes mellitus (T2DM) worldwide, there is an urgent need for new strategies to combat the growing epidemic of these metabolic diseases. (springer.com)
  • This is an efficacy and safety study of ertugliflozin in participants with type 2 diabetes mellitus (T2DM) and inadequate glycemic control on metformin monotherapy. (pfizer.com)
  • Metabolic syndrome (MetS) represents a group of physiological abnormalities involving central obesity, hypertension, dyslipidemia, and insulin resistance, which are strongly associated with an increased risk of cardiovascular event and adult-onset diabetes mellitus (T2DM) ( 1 ). (frontiersin.org)
  • Introduction: Type 2 Diabetes Mellitus (T2DM) is a complex disorder caused by the interaction between genetic predisposition and environmental factors. (scirp.org)
  • Results: The frequency of the rare Thr54 allele of the FABP-2 polymorphism in control (0.33) was not different from the frequency in T2DM (0.27), whereas the frequency of the rare Ala12 allele of the PPAR-Introduction: Type 2 Diabetes Mellitus (T2DM) is a complex disorder caused by the interaction between genetic predisposition and environmental factors. (scirp.org)
  • Twenty-eight studies were identified for analysis, with a total of 2,313 type 2 diabetes mellitus (T2DM) patients. (go.jp)
  • Diabetes is an umbrella term for conditions such as type I (T1DM) and type II (T2DM) diabetes mellitus , gestational diabetes , and maturity-onset diabetes of the young (MODY) . (wikidoc.org)
  • Type 2 Diabetes Mellitus (T2DM) is defined by insulin resistance and presents in adults. (wikidoc.org)
  • Whether SARS-CoV causes T1DM or T2DM or a new type of Diabetes . (wikidoc.org)
  • We overviewed the pathophysiological features of diabetes in relation to its complications in type 1 and type 2 mice along with rat models, including Zucker Diabetic Fatty (ZDF) rats, BB rats, LEW 1AR1/-iddm rats, Goto-Kakizaki rats, chemically induced diabetic models, and Nonobese Diabetic mouse, and Akita mice model. (hindawi.com)
  • This paper briefly reviews the wide pathophysiological and molecular mechanisms associated with type 1 and type 2 diabetes, particularly focusing on the challenges associated with the evaluation and predictive validation of these models as ideal animal models for preclinical assessments and discovering new drugs and therapeutic agents for translational application in humans. (hindawi.com)
  • The two most common types of diabetes mellitus are type 1 diabetes (T1D) and type 2 diabetes (T2D). (hindawi.com)
  • Type 1 diabetes is generally thought to be precipitated by an immune-associated, if not directly immune-mediated, destruction of insulin-producing pancreatic β cells [ 2 , 3 ]. (hindawi.com)
  • Type 2 diabetes (T2D) is associated with insulin resistance and a lack of adequate compensation by the beta cells which lead to a relative insulin deficiency [ 7 ]. (hindawi.com)
  • Attaining deficiency in insulin production in type 1 diabetes mellitus can occur by a variety of different mechanisms ranging from chemical ablation of the beta cells to breeding rodents that spontaneously develop autoimmune diabetes. (hindawi.com)
  • Since the animals used to study type 1 diabetes are highly inbred with a limited number of pathways to T1D, the relevance to human T1D has been questioned [ 9 ]. (hindawi.com)
  • In type 2 diabetes (T2D) mellitus, numerous animal models have been developed for understanding the pathophysiology of diabetes and its complications [ 10 ]. (hindawi.com)
  • An integrated experimental and computational approach to understanding complex disease: Differential gene expression in type 2 diabetes mellitus. (umich.edu)
  • Preclinical rodent models that manifest type 2 diatetes mellitus using either streptozotocin (DMIS) or alloxan (DMIA) have been well established. (nih.gov)
  • Cytokines are soluble signalling mediators within the immune system, and have been shown to be of importance in the development of type 1 diabetes (T1D). (dissertations.se)
  • Type 1 diabetes mellitus (T1DM) is a complex multifactorial disorder which involves a loss of self-tolerance leading to the autoimmune destruction of pancreatic β−cells. (omicsonline.org)
  • Type 1 diabetes mellitus (T1DM) is a devastating chronic metabolic disease whose incidence has been rising at alarming rates during the last decade [ 1 ]. (omicsonline.org)
  • Cross-sectional study of the Fukuoka Cohort revealed an inverse relation between serum bilirubin level and the prevalence of type 2 diabetes mellitus. (elsevier.com)
  • These results suggested that oxidative stress is an exacerbating factor of type 2 diabetes mellitus and that antioxidant therapies are of value to diabetic nephropathy. (elsevier.com)
  • Type 1 diabetes requires insulin treatment, whereas type 2 diabetes, which is characterized by insulin resistance, can be treated using a variety of therapeutic approaches. (ajas.info)
  • Several animal models of diabetes have been used to develop oral therapeutic agents, including sulfonylureas, biguanides, thiazolidinediones, acarbose, and miglitol, for both type 1 and type 2 diseases. (ajas.info)
  • Experimental study of PCB126 exposure on induction of Diabetes mellitus type II. (usp.br)
  • Cheekurthy AJP, Rambabu C, Kumar A (2015) Biochemical Biomarkers-Independent Predictors of Type 2 Diabetes Mellitus. (omicsonline.org)
  • This case control observational study is an attempt to interpret data obtained from biochemical investigation of diagnostic biochemical parameters of complete blood count and lipid profile for their pathological implication and in prediction risk of Type 2 diabetes mellitus and related complications among the healthy subjects. (omicsonline.org)
  • Among the non-genetic biomarkers the biochemical biomarkers are the independent predictors of Type 2 diabetes. (omicsonline.org)
  • Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy. (qxmd.com)
  • with diabetes mellitus type 2 admitted to the First People's Hospital of Jinan (Jinan, China), from June 2012 to June 2016 were selected into the study. (tripdatabase.com)
  • When deciding to start a statin, consider the 23 UMHS Management of Type 2 Diabetes Mellitus June, 2017 patient's 10 year ASCVD risk, nutritional status and life expectancy. (tripdatabase.com)
  • This is a prospective, randomized, open-label comparison of the effects and safety of barley meal plus diabetes diet on blood glucose fluctuations in patients with type 1 diabetes (T1DM) using multiple daily insulin injections (MDI). (clinicaltrials.gov)
  • If I'd known about the subtitle, I wouldn't have been interested in reading the book, since the "medical approach" bit indicated for me that it consisted of traditional precepts penned by a doctor, and also I am not particularly interested in Type 2 diabetes, only Type 1, which I myself have. (docwellnessformula.com)
  • When 69-year-old Sandi, of Houston, was diagnosed with type 2 diabetes in 2007, she was confident she'd be able to manage the disease well. (docwellnessformula.com)
  • People with full-blown type 2 diabetes are not able to use the hormone insulin properly, and have what's called insulin resistance. (docwellnessformula.com)
  • Type 2 diabetes in east Asians: Similarities and differences with populations in Europe and the United States. (springer.com)
  • Timmers S, Hesselink MK, Schrauwen P. Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits? (springer.com)
  • TRF ameliorated lipid induced nephropathy in type-2 diabetes by its hypoglycemic, hypolipidemic and antioxidant activities as well as by modulation of TGF-β to prevent increased expression of collagen type IV and fibrinogen. (osti.gov)
  • However, mechanisms underlying these effects remain unclear.Methods: To evaluate the possible mechanisms underlying these actions, we assessed the systemic effects of diesel exhaust particles (DEP) in control mice, and mice with streptozotocin-induced type 1 diabetes. (elsevier.com)
  • Type 2 diabetes mellitus is reported to be treated by modern drugs including insulin. (m-sciences.com)
  • Two landmark intervention studies, the Diabetes Control and Complications Trial (DCCT) in patients with type 1 diabetes mellitus and the United Kingdom Prospective Diabetes Study (UKPDS) in patients with type 2 diabetes mellitus, have unequivocally demonstrated that intensive diabetes therapy reduces the risk of long-term diabetic complications. (elsevier.com)
  • It was concluded that under experimental DM there disturbance took place function of not in only sensory fibers, as it was described in our previous studies, but also the motor fibers, of though when compared to the sensory deficit, the pathology of this type of fiber is expressed somewhat weaker because of the likely possibility of remodeled properties. (vpbm.com.ua)
  • Adults with type 2 diabetes using Lantus® (insulin glargine) as their basal insulin, not at glycemic goal. (pfizer.com)
  • What is the source of renal lesions in type 1 diabetes mellitus (DM)? (medscape.com)
  • Aathira R, Jain V. Advances in management of type 1 diabetes mellitus. (medscape.com)
  • Tao B, Pietropaolo M, Atkinson M, Schatz D, Taylor D. Estimating the cost of type 1 diabetes in the U.S.: a propensity score matching method. (medscape.com)
  • Prevalence of Type 1 diabetes autoantibodies (GAD and IA2) in Sardinian children and adolescents with autoimmune thyroiditis. (medscape.com)
  • Noble JA, Valdes AM. Genetics of the HLA region in the prediction of type 1 diabetes. (medscape.com)
  • Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes. (medscape.com)
  • Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus. (medscape.com)
  • Use of the Estimated Glucose Disposal Rate (eGDR) as a Measure of Insulin Resistance in an Urban Multiethnic Population With Type 1 Diabetes. (medscape.com)
  • A genome-wide search for human type 1 diabetes susceptibility genes. (medscape.com)
  • Secondary attack rate of type 1 diabetes in Colorado families. (medscape.com)
  • The geoepidemiology of type 1 diabetes. (medscape.com)
  • HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. (medscape.com)
  • How does the incidence of type 1 diabetes mellitus (DM) vary by age? (medscape.com)
  • Previously referred to as juvenile-onset diabetes, type 1 DM is typically diagnosed in childhood, adolescence, or early adulthood. (medscape.com)
  • This slower-onset adult form of type 1 DM is referred to as latent autoimmune diabetes of the adult (LADA). (medscape.com)
  • The report also found that because type 2 DM is far more common than type 1 in individuals in the 31- to 60-year age group, with type 1 DM making up only 4% of all diabetes cases in this population, identification of type 1 DM is difficult in patients over age 30 years. (medscape.com)
  • Blockade of the renin-angiotensin-aldosterone system (RAAS) is the cornerstone treatment of incipient and overt diabetic nephropathy, and in type 2 diabetes angiotensin II receptor blockers (ARBs) such as irbesartan are considered standard treatment after the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria (IRMA) 2 Study ( 3 ) and Irbesartan Diabetic Nephropathy Trial (IDNT) ( 1 ). (diabetesjournals.org)
  • The drug is approved for treatment of hypertension but has also shown renoprotective potential in patients with type 2 diabetes and albuminuria ( 4 , 5 ). (diabetesjournals.org)
  • We compared the antiproteinuric effect of maximal recommended doses of aliskiren, irbesartan, and the combination in patients with type 2 diabetes and albuminuria. (diabetesjournals.org)
  • I've had Type I diabetes for 12 years now and looked up what Wikipedia has to say about diabetes just out of interest. (wikipedia.org)
  • Diabetes mellitus type 1 ) gives no idea whatsoever of what living with diabetes means to the patient. (wikipedia.org)
  • More info about type 1 in Diabetes#Genetics , please, and be more specific about type 1 incidence in Diabetes#Statistics or in Diabetes mellitus type 1 . (wikipedia.org)
  • A Study To Evaluate The Efficacy And Safety Of Ertugliflozin In Participants With Type 2 Diabetes Mellitus And Inadequate Glycemic Control On Metformin Monotherapy (MK-8835-007). (pfizer.com)
  • A Phase 3, Randomized, Double-Blind, Placebo-Controlled, 26-Week Multicenter Study With a 78-Week Extension To Evaluate The Efficacy And Safety Of Ertugliflozin In Subjects With Type 2 Diabetes Mellitus And Inadequate Glycemic Control On Metformin Monotherapy. (pfizer.com)
  • In particular, type 1 diabetes compromises the cardiac function of individuals at a relatively early age due to the protracted course of abnormal glucose homeostasis. (nih.gov)
  • Our studies also show that in vivo MRI could be used in the evaluation of cardiac dysfunction in this rat model of type 1 diabetes. (nih.gov)
  • Specifically, a microchip comprising a combination of at least two different mutant genes wherein each gene comprises at least one mutation indicative of a predisposition for type-2 diabetes in a member of a Chinese population is disclosed. (freepatentsonline.com)
  • 1. A microchip comprising: a combination of at least two different mutant nucleic acid sequences of a wild-type nucleic acid sequence, wherein each wild-type nucleic acid sequence encodes a protein involved in insulin secretion, wherein said gene comprises at least one mutation indicative of a predisposition for type 2 diabetes in a member of a Chinese population. (freepatentsonline.com)
  • 3. The microchip according to claim 1, wherein said type 2 diabetes is maturity onset diabetes of the young. (freepatentsonline.com)
  • type 2 diabetes mellitus patients on glycemic control, as measured by change in HbA1c from baseline to end of treatment (EOT). (bioportfolio.com)
  • 456 Chinese subjects with Type 2 Diabetes Mellitus will be enrolled in the trial. (bioportfolio.com)
  • The purpose of this clinical study is to determine the safety and efficacy of an investigational drug in patients with type 2 diabetes mellitus. (bioportfolio.com)
  • This study will evaluate the efficacy, safety, tolerability, and pharmacokinetics of oral GK Activator (2), compared to placebo, in patients with type 2 diabetes mellitus. (bioportfolio.com)
  • The objectives of the study is to evaluate the efficacy, safety, and dose of DS-8500a compared with placebo in patients with type 2 diabetes mellitus. (bioportfolio.com)
  • Effects of Liraglutide Versus Placebo on Cardiovascular Events in Patients With Type 2 Diabetes Mellitus and Chronic Kidney Disease. (bioportfolio.com)
  • LEADER trial (Liraglutide Effect and Action in Diabetes: Evaluation of CV Outcome Results) results demonstrated cardiovascular benefits for patients with type 2 diabetes mellitus at high cardiovascula. (bioportfolio.com)
  • 1,5 Anhydroglucitol (1,5 AG) is reported to be a more sensitive marker of glucose variability and short-term glycemic control (1-2 weeks) in patients with type1 and type 2 diabetes. (bioportfolio.com)
  • Type II diabetes mellitus is no longer considered a disease exclusively found in adults. (bioportfolio.com)
  • A patient whose diabetes is controlled with diet or an oral antidiabetic agent clearly has type 2 DM. (medscape.com)
  • A lean patient who has had diabetes since childhood, who has always been dependent on insulin, or who has a history of diabetic ketoacidosis (DKA) almost certainly has type 1 DM. (medscape.com)
  • Distinguishing the type of diabetes can be difficult in (1) patients who are treated with insulin and who are younger but clinically appear to have type 2 DM and (2) older patients with late-onset diabetes who nonetheless take insulin and seem to share characteristics of patients with type 1 DM. (medscape.com)
  • Although monogenic diabetes syndromes are not very common, representing fewer than 5% of pediatric diabetes cases, it is important to avoid misdiagnosis of monogenic DM as type 1 or type 2 DM. (medscape.com)
  • Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
  • It is not unusual for patients with type 1 diabetes to present with diabetic ketoacidosis (DKA). (medscape.com)
  • An international expert committee appointed by the ADA, the European Association for the Study of Diabetes, and the International Diabetes Association recommended the HbA 1c assay for diagnosing type 1 diabetes only when the condition is suspected but the classic symptoms are absent. (medscape.com)
  • Screening for type 1 diabetes in asymptomatic low-risk individuals is not recommended. (medscape.com)
  • [ 2 ] However, in patients at high risk (eg, those who have first-degree relatives with type 1 diabetes), it may be appropriate to perform annual screening for anti-islet antibodies before the age of 10 years, along with 1 additional screening during adolescence. (medscape.com)
  • All patients with type 1 diabetes should learn how to self-monitor and record their blood glucose levels with home analyzers and adjust their insulin doses accordingly. (medscape.com)
  • Patients with type 1 diabetes require lifelong insulin therapy. (medscape.com)
  • Higher plasma uric acid (PUA) levels are associated with lower glomerular filtration rate (GFR) and higher blood pressure (BP) in patients with type 1 diabetes (T1D). (diabetesjournals.org)
  • Interestingly, extracellular PUA levels are lower in young adults and adolescents with type 1 diabetes (T1D) compared with healthy control subjects (HCs) ( 2 - 4 ), likely due to a stimulatory effect of urinary glucose on the proximal tubular GLUT9 transporter, which induces uricosuria ( 2 ). (diabetesjournals.org)
  • Type 1 diabetes mellitus (T1DM) is an autoimmune disease. (scirp.org)
  • 2005) Paratuberculosis and Type I Diabetes Mapping the TRIGR. (scirp.org)
  • 2006) Paratuberculosis and Type I diabetes: is this the trigger? (scirp.org)
  • Gross, B. and Staels, B. (2007) PPAR Agonists: Multimodal Drugs for the Treatment of Type-2 Diabetes. (scirp.org)
  • This is a prospective pilot study which will enroll patients with type 1 diabetes mellitus within the first months of diagnosis, with clinical and laboratory findings. (bioportfolio.com)
  • This is a phase II trial in individuals who have been diagnosed with type 1 diabetes within the previous 6 months. (bioportfolio.com)
  • The study evaluates the effect of inactivation of the immune system with chemotherapy and immunotherapy and infusion of bone marrow stem cells in early onset type 1 diabetes mellitus. (bioportfolio.com)
  • Lack of persistent remission following initial recovery in patients with type 1 diabetes treated with autologous peripheral blood stem cell transplantation. (bioportfolio.com)
  • To assess metabolic control in patients with newly diagnosed type 1 diabetes mellitus who underwent immunoablation followed by autologous peripheral blood stem cell transplantation (APBSCT) as a treat. (bioportfolio.com)
  • When a person has type 2 diabetes , the food they eat can make a difference to their wellbeing. (medicalnewstoday.com)
  • In 2010, however, results of a study that looked at 146 South Asian Indians living in the United States suggested that those who followed a high-protein diet also had a higher risk of type 2 diabetes. (medicalnewstoday.com)
  • In 2017, a small study of 22 people found that including whey protein in the diet might help some people with type 2 diabetes. (medicalnewstoday.com)
  • People with type 2 diabetes can mix protein powder with milk and add a piece of fruit for a healthful snack. (medicalnewstoday.com)
  • associated with Diabetes Mellitus, Type 2, DNA:promoter:repeat:g. (mcw.edu)
  • Detecting early cardiovascular disease markers for children and adolescents with type 1 diabetes. (yale.edu)
  • From pumps to prevention: recent advances in the treatment of type 1 diabetes Jennifer Sherr, MD, Eda Cengiz, MD, and William V. Tamborlane, MD Drug Discov Today. (yale.edu)
  • Recent advances in the treatment of type 1 diabetes in children Recent advances in the treatment of type 1 diabetes in children. (yale.edu)
  • The early pharmacodynamic and pharmacokinetic effects of mixing lispro with glargine insulin: results of glucose clamp studies in youth with type 1 diabetes. (yale.edu)
  • Type 1 diabetes results from the pancreas's failure to produce enough insulin due to loss of beta cells . (wikipedia.org)
  • Type 2 diabetes begins with insulin resistance , a condition in which cells fail to respond to insulin properly. (wikipedia.org)
  • Type 1 diabetes must be managed with insulin injections . (wikipedia.org)
  • [2] Prevention and treatment of type 2 diabetes involves maintaining a healthy diet , regular physical exercise , a normal body weight, and avoiding use of tobacco . (wikipedia.org)
  • [2] Type 2 diabetes may be treated with medications such as insulin sensitizers with or without insulin. (wikipedia.org)
  • [16] Weight loss surgery in those with obesity is sometimes an effective measure in those with type 2 diabetes. (wikipedia.org)
  • As of 2019 [update] , an estimated 463 million people had diabetes worldwide (8.8% of the adult population), with type 2 diabetes making up about 90% of the cases. (wikipedia.org)
  • [24] Symptoms may develop rapidly (weeks or months) in type 1 diabetes, while they usually develop much more slowly and may be subtle or absent in type 2 diabetes. (wikipedia.org)
  • People (usually with type 1 diabetes) may also experience episodes of diabetic ketoacidosis (DKA), a metabolic disturbance characterized by nausea, vomiting and abdominal pain , the smell of acetone on the breath, deep breathing known as Kussmaul breathing , and in severe cases a decreased level of consciousness. (wikipedia.org)
  • Type 2 diabetes mellitis is by far the most prevalent type of diabetes among adults. (womenfitness.net)
  • SGLT2 inhibitors reduced glomerular hyperfiltration in patients with type 1 diabetes, and in patients with type 2 diabetes, they caused transient acute reductions in glomerular filtration rate, followed by a progressive recovery and stabilization of renal function. (diabetesjournals.org)
  • The diabetic syndromes include type 1 diabetes with immune destruction of the pancreatic islets, type 2 diabetes with a complex pathophysiology of insulin resistance combined with insulin secretory failure, distinct monogenetic abnormalities (maturity onset diabetes of the young - MODY), and extreme insulin resistance of several different etiologies. (springer.com)
  • We conducted a systematic review and meta-analysis to evaluate the effect of Berberine on glucose in patients with type 2 diabetes mellitus and identify potential factors may modifying the hypoglycemic effect. (go.jp)
  • Controlling blood glucose level in people with diabetes will help reduce morbidity and mortality globally [ 3 Xie W, Zhao Y, Zhang Y (2011) Traditional chinese medicines in treatment of patients with type 2 diabetes mellitus. Evid Based Complement Alternat Med 2011: 726723. " data-html="true" data-placement="bottom" data-toggle="tooltip">3 ]. (go.jp)
  • The excess of diabetes reported for the Benzene Sub registry occurred in the group aged 10 to 17 years, suggesting it is likely that IDDM is the type of diabetes most prevalent. (ghanaweb.com)
  • Therefore in agreement with this, the SARS-CoV-2 might enter pancreatic islets through binding to ACE2 , and cause acute β-cell injury, leading to intense hyperglycemia and transient Type 2 Diabetes Mellitus . (wikidoc.org)
  • Type 1 Diabetes Mellitus is caused by pancreatic β-cell failure or auto-immune destruction of the pancreatic β-cells. (wikidoc.org)
  • In early May, he was diagnosed with type 1 diabetes , and his physician, Tim Hollstein at the University Hospital Schleswig-Holstein in Kiel, suggested that the sudden onset might be linked to the viral infection . (wikidoc.org)
  • Future research is needed to provide a better understanding of the type of Diabetes , SARS-CoV-2 can cause. (wikidoc.org)
  • The study population will be 70 patients (35 experimental and 35 controls) of 11 primary care centers in Mexico City, with diagnosis of type II diabetes mellitus and / or obesity. (centerwatch.com)
  • Diabetes mellitus disease, commonly known as diabetes, is a group of metabolic disorders characterized by high blood glucose levels for a prolonged time. (hindawi.com)
  • Diabetes mellitus is well known as a chronic metabolic disease that is characterized by a relative or absolute lack of insulin, resulting in hyperglycemia. (hindawi.com)
  • The environmental exposure to persistent organic pollutants has been widely highlighted in recent literature due to the extensive association between the development of metabolic diseases, obesity and/or diabetes mellitus, and presence of these pollutants, especially organochlorines such as polychlorinated biphenyls (PCBs) in organism. (usp.br)
  • Diabetes mellitus is a multifaceted group of metabolic diseases characterized by the accumulation of sugar in the blood (hyperglycemia). (omicsonline.org)
  • In this context, the pharmacological approaches to treat diabetes should not only correct hyperglycaemia, but also attenuate inflammation and prevent the development of metabolic and cardiovascular complications. (frontiersin.org)
  • Menopause is a physiological process and diabetes is a metabolic disease that occurs more frequently in older women. (ac.ir)
  • ATP-dependent K(+) channels contribute to local metabolic coronary vasodilation in experimental diabetes. (biomedsearch.com)
  • The sections in this chapter of other health outcomes include chloracne, porphyria cutanea tarda, other metabolic and digestive disorders (diabetes mellitus, alterations in hepatic enzymes, lipid abnormalities, and gastrointestinal ulcers), immune system disorders (immune modulation, autoimmunity), and a number of circulatory and respiratory disorders. (nap.edu)
  • DIABETES MELLITUS , a metabolic disorder of the endocrine system, is one of the most common chronic diseases worldwide. (go.jp)
  • Diabetes is an important risk factor for cardiovascular disease and chronic kidney disease [ 2 Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (2014) Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment. Lancet Diabetes Endocrinol 2: 634-647. " data-html="true" data-placement="bottom" data-toggle="tooltip">2 ]. (go.jp)
  • Metabolic syndrome is a cluster of cardiovascular disease and diabetes risk factors including excess waist circumference, high blood pressure, elevated triglycerides, low levels of high-density lipoprotein (HDL "good" cholesterol) and high fasting glucose levels. (ghanaweb.com)
  • The aim of this review was to discuss aspects that involve metabolic and functional alterations of copper in Diabetes Mellitus. (scielo.br)
  • Hyperglycemia is thought to be a primary factor in the onset of diabetes, although hyperlipidemia also plays a role. (ajas.info)
  • We investigated the effects of hyperglycemia on EMT in the lungs of gerbils with streptozotocin (STZ)-induced diabetes. (elsevier.com)
  • In conclusion, our study demonstrates that hyperglycemia induces EMT and contributes to lung fibrosis in an experimental DM model. (elsevier.com)
  • Abstract -Experimental renal disease models establish glomerular hypertension as a crucial determinant in glomerulosclerosis progression and demonstrate that glomerular capillary pressure reduction delays sclerosis development. (ahajournals.org)
  • A sample of 74 subjects diagnosed with obesity (experimental group, n = 37 and control group, n = 37) was conducted. (mdpi.com)
  • Purnell, JQ & Weyer, C 2003, ' Weight effect of current and experimental drugs for diabetes mellitus: From promotion to alleviation of obesity ', Treatments in Endocrinology , vol. 2, no. 1, pp. 33-47. (elsevier.com)
  • Second Stage: Application of brief intervention (PST) in patients with diagnosis of Diabetes and Obesity. (centerwatch.com)
  • Takayanagi, R, Inoguchi, T & Ohnaka, K 2011, ' Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus ', Journal of Clinical Biochemistry and Nutrition , vol. 48, no. 1, pp. 72-77. (elsevier.com)
  • Oxidative stress plays an important role in diabetes mellitus (DM)-associated vascular injury. (ahajournals.org)
  • Antioxidant SOD mimetic prevents NADPH oxidase-induced oxidative stress and renal damage in the early stage of experimental diabetes and hypertension. (qxmd.com)
  • Diabetes mellitus (DM), a chronic hyperglycaemic disorder, is characterized by an increase in the oxidative stress. (m-sciences.com)
  • 2. Chorioamnionitis and oxidative stress: New ideas from experimental models. (indigo.ca)
  • 3. Oxidative stress in the pathophysiology of gestational diabetes mellitus. (indigo.ca)
  • Both DMIS and DMIA models have served as key experimental tools to evaluate and understand the pharmacokinetic disposition of scores of drugs and therefore some key questions with respect to absorption, metabolism or elimination of drugs can be answered during the development of full-blown diabetes in the animal models. (nih.gov)
  • The established exposure procotol was characterized and considered sufficient to cause toxicity since changes were observed in the immune system, metabolism and in parameters related to the pathogenesis of diabetes mellitus. (usp.br)
  • Diabetes mellitus (DM) is a syndrome that interferes with the metabolism of carbohydrates. (scielo.br)
  • Bella LM, Fieri I, Azevedo CB de, Tessaro FHG, Nolasco EL, Nunes FPB, Ferreira S de S, Martins J de O. Effect of vitamin D supplementation in the experimental model of diabetes mellitus. (usp.br)
  • Apple cider vinegar possesses significant antihyperglycemic and antioxidant effects in an experimental model of diabetes mellitus. (greenmedinfo.com)
  • As a result, the commonly accepted treatment goal for most patients with diabetes is the achievement and maintenance of glycemic control that is as close to the normal range as safely possible. (elsevier.com)
  • the recent long-term follow-up results of the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation Post-Trial Observational Study (ADVANCE-ON) ( 6 ) have strengthened the concept that optimal glycemic control is effective in preventing DN and, interestingly, in slowing progression. (diabetesjournals.org)
  • Strategies for preclinical pharmacokinetic investigation in streptozotocin-induced diabetes mellitus (DMIS) and alloxan-induced diabetes mellitus (DMIA) rat models: case studies and perspectives. (nih.gov)
  • Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease. (qxmd.com)
  • The overproduction of NO during the development of streptozotocin-induced diabetes is probably an important part of the complex autoimmune reaction which leads to the destruction of pancreatic beta-cells. (nih.gov)
  • We also perceived a marked difference in cytokine response depending on the mouse strain used in the experiments.Finally, we aimed to elucidate if, besides autoimmune activities, also high glucose- and free fatty acid concentrations as seen in diabetes could cause changes in cytokine production. (dissertations.se)
  • It is worth noting that while addressing the hypothesis of the role of class II major histocompatibility glycoproteins in autoimmune diabetes (insulin-dependent diabetes, IDDM) a number of investigators established animal models in which class II molecules were expressed under the control of the rat insulin promoter. (springer.com)
  • In the murine model for multiple sclerosis, experimental autoimmune encephalomyelitis, pathogenic T cells exhibit a Th1-like phenotype characterized by heightened expression of proinflammatory cytokines. (jimmunol.org)
  • Therefore, we adoptively transferred myelin basic protein-specific CD4 + T cells transduced to express IL-12 p40 into mice immunized to develop experimental autoimmune encephalomyelitis and demonstrated a significant reduction in clinical disease. (jimmunol.org)
  • Indeed, we have demonstrated that autoantigen-specific T cell hybridomas retrovirally transduced to express a regulatory cytokine, IL-4, were capable of trafficking to autoimmune lesions in the CNS to ameliorate experimental autoimmune encephalomyelitis (EAE) 4 ( 20 ). (jimmunol.org)
  • This latter group is now said to have latent autoimmune diabetes of the adult [LADA]. (medscape.com)
  • In humans, MAP is the putative cause of Crohn's disease and has been linked to sarcoidosis, autoimmune thyroiditis, multiple sclerosis and autoimmune diabetes. (scirp.org)
  • Furthermore, animal models play a vital role in the understanding of diabetes pathogenesis as they allow the combination of genetic and functional characterization of the syndrome [ 8 ]. (hindawi.com)
  • Work at this institute and the Steno Memorial Hospital has been dedicated to research in diabetes for decades, and the insti- tutions were appointed WHO Collaborating Centres for Re- search and Training on the Pathogenesis of Diabetes Mellitus in 1983. (springer.com)
  • The pathogenesis of pulmonary fibrosis in diabetes remains unknown. (elsevier.com)
  • Diabetes mellitus (DM) is a chronic disease that affects nowadays millions of people worldwide. (frontiersin.org)
  • Diabetes mellitus is nowadays acknowledged as a low-grade chronic inflammatory condition characterized by the over-secretion of pro-inflammatory cytokines. (frontiersin.org)
  • Statins may not be appropriate in some patients with diabetes , especially those with severe, chronic malnutrition from pancreatic insufficiency or women planning pregnancy. (tripdatabase.com)
  • In chronic experimental diabetic rats where PRA, plasma aldosterone concentration, and urinary excretion of prostaglandin E 2 were significantly decreased, a significant attenuated response of aldosterone secretion was demonstrated after infusion of angiotensin II, ACTH, or potassium. (elsevier.com)
  • These results suggest that defects in aldosterone synthesis exist in chronic experimental diabetic rats and that potassium homeostasis is impaired during acute potassium loading. (elsevier.com)
  • Diabetes mellitus (DM) reduces lung function and increases the risk of asthma, chronic obstructive pulmonary disease, pneumonia, and pulmonary fibrosis. (elsevier.com)
  • There is growing evidence that the function of several types of vascular K + channels is altered during major cardiovascular diseases, such as chronic hypertension, diabetes, and atherosclerosis. (ahajournals.org)
  • Diabetic nephropathy (DN) is a major burden among the chronic complications of diabetes, given that it affects ∼30% of patients with diabetes. (diabetesjournals.org)
  • Human plasma C-peptide immunoreactivity: Its correlation with immunoreactive insulin in diabetes, and chronic liver and renal diseases. (nii.ac.jp)
  • Diabetes and depression are chronic diseases that affect the quality of life of people and they increase disability and reduced life expectancy. (centerwatch.com)
  • An increase in glomerular filtration rate (GFR) in early diabetes mellitus is considered a risk factor for the development of diabetic nephropathy. (aspetjournals.org)
  • Dyslipidemia is common in patients with diabetes mellitus (DM) and is considered a risk factor for the progression of diabetic nephropathy (DN). (osti.gov)
  • Experimental diabetes is associated with a marked increase in exposure to endogenous formation of methylglyoxal-derived hydroimidazolone which is linked to the development of diabetic nephropathy. (nih.gov)
  • To avoid late complications of diabetes and related costs, primary prevention and early treatment are therefore necessary. (hindawi.com)
  • Since microvascular complications of diabetes are mainly determined by redox mechanisms, the evaluation of these parameters might help in characterizing the risk of vascular complication for diabetes patients. (akjournals.com)
  • There was a more than four-fold increase in the extent of glycation of tubulin in the sciatic nerve of rats with streptozotocin-induced diabetes of 2 weeks duration compared with control rats. (nih.gov)
  • experimental and clinical implications. (nih.gov)
  • Further clarification of the role of nitric oxide in streptozotocin-induced diabetes development could have important clinical implications. (nih.gov)
  • This review will summarize the main experimental and clinical findings obtained with pharmacological IL-1β inhibitors in the context of the cardiovascular complications of DM, and discuss the perspectives of IL-1β inhibitors as novel therapeutic tools for treating these patients. (frontiersin.org)
  • This study demonstrates the impact that diabetes has on acute wound healing and suggests that wound modulating agents must be tested in both the tightly glucose-controlled as well as the poorly glucose-controlled diabetic animal models prior to proceeding with translational clinical studies. (lenus.ie)
  • Pharmacological agents with antihyperglycemic and positive weight effects have the potential to become important additions to our therapeutic armamentarium, in that they may help to achieve glycemic targets while addressing the long-standing clinical problem of weight gain as an adverse effect of intensive diabetes therapy. (elsevier.com)
  • For further information about the diagnosis and management of monogenic diabetes, the ADA suggests consulting the 2009 clinical practice consensus guidelines of the International Society for Pediatric and Adolescent Diabetes (ISPAD) at the ISPAD website . (medscape.com)
  • See Clinical Findings in Diabetes Mellitus , a Critical Images slideshow, to help identify various cutaneous, ophthalmologic, vascular, and neurologic manifestations of DM. (medscape.com)
  • N-acetylglucosaminidase activity in experimental and clinical diabetes mellitus. (nii.ac.jp)
  • Early enteral nutrition and total parenteral nutrition on the nutritional status and blood glucose in patients with gastric cancer complicated with diabetes mellitus after radical gastrectomy Effects of early enteral nutrition (EEN) or total parenteral nutrition (TPN) support on nutritional status and blood glucose in patients with gastric cancer complicated with diabetes mellitus after radical gastrectomy were investigated. (tripdatabase.com)
  • During the lead-in period, no interventions were given to the patient's diet from day 1 to day 4, and diabetes diet education and guidance were given from day 5 to day 8, depending on the patient's blood glucose and diet. (clinicaltrials.gov)
  • To further elucidate this hypothesis we performed renal clearance experiments in anesthetized rats at 2 and 6 weeks after onset of streptozotocin-induced insulin-treated diabetes mellitus and studied the acute effect of the putative K ATP channel blocker 4-morpholinecarboximidine-N-1-adamantyl-N′-cyclohexylhydrochloride (U37883A) on renal function. (aspetjournals.org)
  • Participation of renal prostanoids in development of diabetes-induced nephropathy was studied in rats with streptozotocin diabetes. (msk.ru)
  • Methods and Results -We studied the effect of BQ-3020, a highly selective ETBR agonist, on renal vascular resistance and nitric oxide (NO) release in the isolated, perfused kidney of rats with hypertension, diabetes mellitus, and hypercholesterolemia. (ahajournals.org)
  • It is a significant component of multiple renal lesions in diabetes. (medscape.com)
  • Such relationships between PUA and early renal and cardiovascular risk factors in young patients with T1D suggest that lowering PUA may be an important strategy to reduce renal and cardiovascular complications related to diabetes. (diabetesjournals.org)
  • From the limited data available in patients with diabetes, lowering of PUA levels may improve endothelial function ( 12 ), lower BP ( 13 - 15 ), slow GFR decline, reduce proteinuria, and suppress renal inflammation ( 1 , 16 - 18 ). (diabetesjournals.org)
  • In addition to the activation of the renin-angiotensin-aldosterone system, renal tubular factors, including SGLT2, contribute to glomerular hyperfiltration in diabetes. (diabetesjournals.org)
  • Diabetes is due to either the pancreas not producing enough insulin , or the cells of the body not responding properly to the insulin produced. (wikipedia.org)
  • Del Prato S, Tiengo A. Diabetes secondary to acquired disease of the pancreas. (springer.com)
  • [2] In 2019, diabetes resulted in approximately 4.2 million deaths. (wikipedia.org)
  • Exp Clin Endocrinol Diabetes 2019. (annals.org)
  • Increased formation of reactive oxygen species leading to activation of poly(ADP-ribose) polymerase (PARP)-1 and podocyte loss by apoptosis contribute to albuminuria in diabetes mellitus (DM). (qxmd.com)
  • A new attempt to acknowledge and rekindle interest in the experimental foundation of behavioral medicine, this volume focuses on the relevance of conditioning processes in the development of clinically relevant intervention strategies. (routledge.com)
  • [20] [21] The global economic cost of diabetes related health expenditure in 2017 was estimated at US$727 billion. (wikipedia.org)
  • [10] In the United States, diabetes cost nearly US$327 billion in 2017. (wikipedia.org)
  • The animal was taken into acute experiment on the 30-th day after the modeling (onset of the disease) of diabetes. (vpbm.com.ua)
  • Nomogram for predicting diabetes mellitus after the first attack of acute pancreatitis. (bioportfolio.com)
  • Diabetes mellitus can occur after acute pancreatitis (AP), but there are currently no tools for evaluating the risk of developing diabetes after an attack of AP. (bioportfolio.com)
  • [4] [5] The study suggested, SARS-CoV may damage islets and cause acute insulin dependent diabetes mellitus . (wikidoc.org)
  • Induction of diabetes by streptozotocin led to a 2-fold increase in urinary excretion of Nepsilon-carboxymethyl-lysine and a 27-fold increase in urinary excretion of methylglyoxal-derived hydroimidazolone Ndelta-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine - the latter was decreased by high-dose thiamine therapy that also prevented the development of nephropathy. (nih.gov)
  • Furthermore, because hypercholesterolemia and diabetes mellitus (DM) as well as hypertension are major risk factors for cardiovascular diseases, it is important to know whether similar endothelial alterations in ETBR exist in these states. (ahajournals.org)
  • Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: Therapeutic implications for diabetes and its cardiovascular complications. (springer.com)
  • The present study aims at finding correlations between certain biochemical and biophysical blood parameters for diabetes patients, focusing on the antioxidant status of the red blood cells and the membrane fluidity of peripheral blood mononuclear cells (PBMC), the endothelial function and the risk of stable interaction between the leucocytes and the endothelium. (akjournals.com)
  • Insulin deficiency may increase the activity of ATP-sensitive potassium channels (K ATP ), which could promote afferent arteriolar vasodilation und thus contribute to glomerular hyperfiltration in early diabetes mellitus. (aspetjournals.org)
  • By definition, complex diseases (e.g. hypertension, diabetes, asthma) demonstrate both environmental and genetic factors in disease susceptibility, implicating genes that show both environmental response and genetic variability in predisposing disease. (umich.edu)
  • Most researchers note the development of DN in humans but experimental researches have shown the development of neuropathy in early onset (several weeks to months). (vpbm.com.ua)
  • To investigate alterations in aldosterone secretion in diabetes mellitus, the effects of angiotensin II, ACTH, and potassium on aldosterone secretion were examined in conscious unrestrained streptozotocin-induced diabetic rats (60 mg/ kg, 12 weeks before study). (elsevier.com)
  • Islet hormone secretion in pancreatic cancer patients with diabetes. (springer.com)
  • Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article. (aspetjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics. (aspetjournals.org)
  • Shirai, H 1996, ' An experimental study on the effect of diabetes mellitus on histopathological changes in the denture supporting tissues under continuous pressure ', The Journal of the Japan Prosthodontic Society , vol. 40, no. 95specialNo. (elsevier.com)
  • The present study investigated the effects of diabetes on some biochemical parameters and histopathological changes in ovariectomized rats. (ac.ir)
  • The animals were estimated for the different biochemical parameters which included liver function test, kidney function test and total lipid profile of experimental animals. (ijpsr.com)
  • The body weight losses and serum biochemical indices are considered as major signs of diabetes mellitus. (scialert.net)
  • The aim of present research was to investigate possible changes in serum biochemical indices and live body weight in German shepherd dogs, as a laboratory model for diabetes studies. (scialert.net)
  • Diabetes mellitus has high correlation with plasma biochemical condition. (scialert.net)
  • Data were collected at rest and during exercise before and after induction of diabetes with alloxan monohydrate (40-60 mg/kg intravenously). (biomedsearch.com)
  • The use of alloxan and streptozotocin in experimental diabetes models / Deneysel Diyabet Modellerinde Alloksan ve Streptozotosin Kullanimi. (thefreelibrary.com)
  • Alloxan monohydrate with 100 mg kg -1 in was injected intravenously for experimental group. (scialert.net)
  • On this basis, animal models should be carefully selected for diabetes investigations depending on what aspects of the disease are being studied. (hindawi.com)
  • It is known from ancient times and is designated as disease of affluence [ 2 ] and overfed, middle aged and elderly people but now the prevalence of diabetes for all age-groups is worldwide [ 3 , 4 ]. (omicsonline.org)
  • Diabetes mellitus (DM) is a cardiometabolic disease that affects millions of people worldwide. (frontiersin.org)
  • Of these two prediabetic states, the latter in particular is a major risk factor for progression to full-blown diabetes mellitus, as well as cardiovascular disease. (docwellnessformula.com)
  • Therefore, the aim of this study was to investigate the bioelectric activity of efferent fibers of the sciatic nerve in experimental DM one month after the beginning of the disease. (vpbm.com.ua)
  • Diabetes is a major risk factor for cardiovascular disease. (nih.gov)
  • Several other signs and symptoms can mark the onset of diabetes although they are not specific to the disease. (wikipedia.org)
  • Recently drinking more than one soft drink daily -- whether it's regular or diet -- may be associated with an increase in the risk factors for heart disease and diabetes, Framingham researchers reported in Circulation: Journal of the American Heart Association. (ghanaweb.com)
  • At the end of the lead-in period, patients were randomly divided into two treatment groups according to the ratio of 1:1: Observation group: Diabetes diet + barley diet. (clinicaltrials.gov)
  • Today Diabetes Relief helps patients actually improve their health and reduce their dependency on medications. (docwellnessformula.com)
  • Along with diabetes education that encourages nutrition and exercise as part of positive lifestyle adjustments, Diabetes Relief's program is changing lives and achieving amazing outcomes for their patients. (docwellnessformula.com)
  • For that purpose we evaluated blood samples from 32 diabetes patients compared to a control group of 10 subjects for erythrocytes' enzymatic activity of glucose-6-phosphate dehydrogenase and of superoxide dismutase, their susceptibility to lipid peroxidation, the plasma nitric oxide stable end products level and the PBMC membrane fluidity. (akjournals.com)
  • Pancreatic volume and endocrine and exocrine functions in patients with diabetes. (medscape.com)
  • High prevalence of capillary abnormalities in patients with diabetes and association with retinopathy. (medscape.com)
  • Turkish Nationwide SurvEy of Glycemic and OtherMetabolic Parameters of Patients with Diabetes Mellitus (TEMD Study). (bioportfolio.com)
  • A fingerstick glucose test is appropriate for virtually all patients with diabetes. (medscape.com)
  • Researchers in China observed new-onset diabetes among SARS-CoV patients. (wikidoc.org)
  • In China, in the year 2008, a study was done in which they compared 39 SARS-CoV patients with no previous history of diabetes, who never used steroids, with 39 matched healthy siblings.The results of the study revealed that 20 out of 39 SARS-CoV patients developed new-onset diabetes during the hospital stay. (wikidoc.org)
  • Patients in the experimental group will receive the PST while the control group will receive usual treatment. (centerwatch.com)
  • The study of Diabetes Mellitus, Experimental has been mentioned in research publications which can be found using our bioinformatics tool below. (novusbio.com)
  • These pathways complement our catalog of research reagents for the study of Diabetes Mellitus, Experimental including antibodies and ELISA kits against INS, ST3GAL4, ALB, CAT, GCG. (novusbio.com)
  • We have 2212 products for the study of Diabetes Mellitus, Experimental that can be applied to Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits. (novusbio.com)
  • This study is an attempt to elucidate of agmatine effects upon leukocyte apoptosis in experimental diabetes mellitus (EDM). (nih.gov)
  • The study of a simple experimental model of myocardial injury in animals was considered of value. (wordpress.com)
  • The present study shows the potential hypoglycemic effect of the various fraction of ethanolic extract of Tecomella undulata and metformin in STZ-NA induced diabetes which may be due to the systematic effect on hepatocytic and pancreatic mechanism. (ijpsr.com)
  • The animals were assigned into a control group, an ovariectomized group (55 weeks), a third group in which diabetes was induced in the last 5 weeks of the study in rats with intact ovary. (ac.ir)
  • The next group included ovariectomized rats (for 55 weeks) in which diabetes was induced in the last 5 weeks of the study. (ac.ir)
  • In a 2010 medical study, it was suggested that medicinal plants might have therapeutic effects on complex diseases such as diabetes. (womenfitness.net)
  • This study was based on the induction of diabetes mellitus by streptozotocin (55 mg/kg, i.p .) in Wistar rats and treated with doses of C. duckei oleoresin (250 and 500 mg/kg, p.o. ). (scielo.br)
  • Co-infection experiments showed that the induction of diabetes by the D variant was inhibited by the B variant. (rupress.org)
  • Induction of diabetes after 24 h was confirmed by an increase in blood sugar and glucosylated haemoglobin and a decrease in serum insulin levels. (bvsalud.org)
  • The first group served as diabetic control, while the second and third groups received PO-TRF and RBO-TRF, respectively by gavage over a period of sixteen weeks post-induction of diabetes. (osti.gov)
  • Four weeks following induction of diabetes, the animals were intratracheally instilled (i.t.) with DEP (0.4 mg/kg) or saline, and several cardiovascular endpoints were measured 24 h thereafter.Results: DEP caused leukocytosis and a significant increase in plasma C-reactive protein and 8-isoprostane concentrations in diabetic mice compared to diabetic mice exposed to saline or non-diabetic mice exposed to DEP. (elsevier.com)
  • 1992). IDDM is associated with a variety of hematologic changes (such as anemia) and malignancies (such as lymphocytic leukemia, lymphoma, and multiple myeloma) that might be directly related to or simply coincidental with the diabetes (Bern, 1982). (ghanaweb.com)
  • Glycation of rat sciatic nerve tubulin in experimental diabetes mellitus. (nih.gov)
  • As lysine residues are the major target for the non-enzymatic attachment of glucose, the effect of diabetes on the extent of glycation of tubulin was investigated. (nih.gov)
  • In contrast, no such increase in glycation was observed in brain microtubule protein from diabetic rats at that stage of diabetes. (nih.gov)
  • The observed glycation of peripheral nerve tubulin in early experimental diabetes may nevertheless contribute to axonal transport abnormalities through an as yet undetermined impairment of microtubule function. (nih.gov)
  • Geographic patterns of childhood insulin-dependent diabetes mellitus. (medscape.com)
  • A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT). (bioportfolio.com)
  • This review provides an overview of diabetes mellitus, describes oral therapeutic agents for diabetes and their targets, and discusses new developments in diabetic drug research. (ajas.info)
  • However, the need for the care of people with diabetes with depression and anxiety symptoms are increasing, and pharmacological and therapeutic treatments are not enough. (centerwatch.com)
  • These studies suggest that the induction of interferon by the B variant is, at least in part, responsible for the inhibition of diabetes by the D variant. (rupress.org)