Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
The formation of clumps of RED BLOOD CELLS under low or non-flow conditions, resulting from the attraction forces between the red blood cells. The cells adhere to each other in rouleaux aggregates. Slight mechanical force, such as occurs in the circulation, is enough to disperse these aggregates. Stronger or weaker than normal aggregation may result from a variety of effects in the ERYTHROCYTE MEMBRANE or in BLOOD PLASMA. The degree of aggregation is affected by ERYTHROCYTE DEFORMABILITY, erythrocyte membrane sialylation, masking of negative surface charge by plasma proteins, etc. BLOOD VISCOSITY and the ERYTHROCYTE SEDIMENTATION RATE are affected by the amount of erythrocyte aggregation and are parameters used to measure the aggregation.
Disease Models, Animal
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Iron Chelating Agents
Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)
Neoplastic Cells, Circulating
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
Effect of intravenous dextran 70 and pneumatic leg compression on incidence of postoperative pulmonary embolism. (1/2888)The incidence of pulmonary embolism and deep vein thrombosis was measured in 50 matched pairs of patients undergoing common surgical procedures with preoperative and postoperative ventilation-perfusion lung scans and the fibrinogen uptake test. One patient in each pair was treated with intravenous dextran 70 and pneumatic leggings. The incidence of pulmonary embolism among the treated patients was significantly reduced from 24% to 8%, but the incidence of deep vein thrombosis was not significantly reduced (34% to 24%). (+info)
Reduction in baroreflex cardiovascular responses due to venous infusion in the rabbit. (2/2888)We studied reflex bradycardia and depression of mean arterial blood pressure (MAP) during left aortic nerve (LAN) stimulation before and after volume infusion in the anesthetized rabbit. Step increases in mean right atrial pressure (MRAP) to 10 mm Hg did not result in a significant change in heart rate or MAP. After volume loading, responses to LAN stimulation were not as great and the degree of attenuation was propoetional to the level of increased MRAP. A change in responsiveness was observed after elevation of MRAP by only 1 mm Hg, corresponding to less than a 10% increase in average calculated blood volume. after an increase in MRAP of 10 mm Hg, peak responses were attenuated by 44% (heart rate) and 52% (MAP), and the initial slopes (rate of change) were reduced by 46% (heart rate) and 66% (MAP). Comparison of the responses after infusion with blood and dextran solutions indicated that hemodilution was an unlikely explanation for the attenuation of the reflex responses. Total arterial baroreceptor denervation (ABD) abolished the volume-related attenuation was still present following bilateral aortic nerve section or vagotomy. It thus appears that the carotid sinus responds to changes inblood volume and influences the reflex cardiovascular responses to afferent stimulation of the LAN. On the other hand, cardiopulmonary receptors subserved by vagal afferents do not appear to be involved. (+info)
Interaction of inflammatory cells and oral microorganisms. II. Modulation of rabbit polymorphonuclear leukocyte hydrolase release by polysaccharides in response to Streptococcus mutans and Streptococcus sanguis. (3/2888)The release of lysosomal hydrolases from polymorphonuclear leukocytes (PMNs) has been postulated in the pathogenesis of tissue injury in periodontal disease. In the present study, lysosomal enzyme release was monitored from rabbit peritoneal exudate PMNs exposed to Streptocccus mutans or Streptococcus sanguis. S. mutans grown in brain heart infusion (BHI) broth failed to promote significant PMN enzyme release. S. sanguis grown in BHI broth, although more effective than S. mutants, was a weak stimulus for promotion of PMN hydrolase release. Preincubation of washed, viable S. mutans in sucrose or in different-molecular-weight dextrans resulted in the ability of the organisms to provoke PMN release reactions. This effect could bot be demonstrated with boiled or trypsinized S. mutans or with viable S. sanguis. However, when grown in BHI broth supplemented with sucrose, but not with glucose, both S. mutans and S. sanguis triggered discharge of PMN enzymes. The mechanism(s) whereby dextran or sucrose modulates PMN-bacterial interaction may in some manner be related to promotion of microbial adhesiveness or aggregation by dextran and by bacterial synthesis of glucans from sucrose. (+info)
Glomerular size-selective dysfunction in NIDDM is not ameliorated by ACE inhibition or by calcium channel blockade. (4/2888)BACKGROUND: In patients with insulin-dependent diabetes mellitus (IDDM) and overt nephropathy glomerular barrier size-selectivity progressively deteriorates with time and is effectively improved by angiotensin converting enzyme (ACE) inhibition. Whether similar glomerular functional changes develop in proteinuric patients with non-insulin-dependent diabetes mellitus (NIDDM), and whether antihypertensive agents can favorably affect glomerular filtration of macromolecules in these patients, has not been documented yet. METHODS: We investigated renal hemodynamics and fractional clearance of neutral dextrans of graded sizes, in nine proteinuric patients with NIDDM and renal biopsy findings of typical diabetic glomerulopathy. Six healthy volunteers served as controls. We also investigated the effects of an ACE inhibitor and of a calcium channel blocker, both given in doses targeted to achieve a comparable level of systemic blood pressure control, on glomerular hemodynamics and sieving function. Theoretical analysis of glomerular macromolecule transport was adopted to evaluate intrinsic glomerular membrane permeability properties. RESULTS: Fractional clearance of large macromolecules (42 to 66 A in radius) was significantly higher in diabetic patients than in controls, and the distribution of membrane pore radii was calculated to be shifted towards larger pore sizes in diabetics (mean radius increased from 55 to 60 A). Despite effective blood pressure control, neither antihypertensive affected glomerular hemodynamics to any significant extent. Fractional clearance of dextrans, as well as of albumin and IgG, and total urinary proteins were not modified by either treatments. CONCLUSIONS: These data indicate that patients with NIDDM and overt nephropathy develop abnormalities in size-selective function of the glomerular barrier and, at variance to IDDM, such changes were not ameliorated either by ACE inhibition or calcium channel blockade. (+info)
Poly(L-lysine)-graft-dextran copolymer promotes pyrimidine motif triplex DNA formation at physiological pH. Thermodynamic and kinetic studies. (5/2888)Extreme instability of pyrimidine motif triplex DNA at physiological pH severely limits its use for artificial control of gene expression in vivo. Stabilization of the pyrimidine motif triplex at physiological pH is therefore of great importance in improving its therapeutic potential. To this end, isothermal titration calorimetry interaction analysis system and electrophoretic mobility shift assay have been used to explore the thermodynamic and kinetic effects of our previously reported triplex stabilizer, poly (L-lysine)-graft-dextran (PLL-g-Dex) copolymer, on pyrimidine motif triplex formation at physiological pH. Both the thermodynamic and kinetic analyses have clearly indicated that in the presence of the PLL-g-Dex copolymer, the binding constant of the pyrimidine motif triplex formation at physiological pH was about 100 times higher than that observed without any triplex stabilizer. Of importance, the triplex-promoting efficiency of the copolymer was more than 20 times higher than that of physiological concentrations of spermine, a putative intracellular triplex stabilizer. Kinetic data have also demonstrated that the observed copolymer-mediated promotion of the triplex formation at physiological pH resulted from the considerable increase in the association rate constant rather than the decrease in the dissociation rate constant. Our results certainly support the idea that the PLL-g-Dex copolymer could be a key material and may eventually lead to progress in therapeutic applications of the antigene strategy in vivo. (+info)
Polymer structure and solubility of deoxyhemoglobin S in the presence of high concentrations of volume-excluding 70-kDa dextran. Effects of non-s hemoglobins and inhibitors. (6/2888)Earlier observations indicated that volume exclusion by admixed non-hemoglobin macromolecules lowered the polymer solubility ("Csat") of deoxyhemoglobin (Hb) S, presumably by increasing its activity. In view of the potential usefulness of these observations for in vitro studies of sickling-related polymerization, we examined the ultrastructure, solubility behavior, and phase distributions of deoxygenated mixtures of Hb S with 70-kDa dextran, a relatively inert, low ionic strength space-filling macromolecule. Increasing admixture of dextran progressively lowered the Csat of deoxyHb S. With 12 g/dl dextran, a 5-fold decrease in apparent Csat ("dextran-Csat") was obtained together with acceptable sensitivity and proportionality with the standard Csat when assessing the effects of non-S Hb admixtures (A, C, and F) or polymerization inhibitors (alkylureas or phenylalanine). The volume fraction of dextran excluding Hb was 70-75% of total deoxyHb-dextran (12 g/dl) volumes. Electron microscopy showed polymer fibers and fiber-to-crystal transitions indistinguishable from those formed without dextran. Thus when Hb quantities are limited, as with genetically engineered recombinant Hbs or transgenic sickle mice, the dextran-Csat provides convenient and reliable screening of effects of Hb S modifications on polymerization under near-physiological conditions, avoiding problems of high ionic strength. (+info)
Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4. (7/2888)1. The effect of IL-4 on responses to intraplantar (i.pl.) carrageenin, bradykinin, TNFalpha, IL-1beta, IL-8 and PGE2 was investigated in a model of mechanical hyperalgesia in rats. Also, the cellular source of the IL-4 was investigated. 2. IL-4, 30 min before the stimulus, inhibited responses to carrageenin, bradykinin, and TNFalpha, but not responses to IL-1beta, IL-8 and PGE2. 3. IL-4, 2 h before the injection of IL-1beta, did not affect the response to IL-1beta, whereas IL-4, 12 or 12+2 h before the IL-1beta, inhibited the hyperalgesia (-30%, -74%, respectively). 4. In murine peritoneal macrophages, murine IL-4 for 2 h before stimulation with LPS, inhibited (-40%) the production of IL-1beta but not PGE2. Murine IL-4 (for 16 h before stimulation with LPS) inhibited LPS-stimulated PGE2 but not IL-1beta. 5. Anti-murine IL-4 antibodies potentiated responses to carrageenin, bradykinin and TNFalpha, but not IL-1beta and IL-8, as well as responses to bradykinin in athymic rats but not in rats depleted of mast cells with compound 40/80. 6. These data suggest that IL-4 released by mast cells limits inflammatory hyperalgesia. During the early phase of the inflammatory response the mode of action of the IL-4 appears to be inhibition of the production TNFalpha, IL-1beta and IL-8. In the later phase of the response, in addition to inhibiting the production of pro-inflammatory cytokines, IL-4 also may inhibit the release of PGs. (+info)
Heterogeneity in the ability of cytotoxic murine NK cell clones to enhance Ig secretion in vitro. (8/2888)We recently described a panel of cytotoxic murine NK cell clones that also enhanced Ig secretion by B cells activated in an in vitro model of T cell-independent type 2 (TI-2) responses. We employed dextran-conjugated anti-IgD (alphadelta-dex) as a model antigen. Here we study the mechanism of Ig induction by these clones. Addition of the various NK clones to sort-purified B cells stimulated with alphadelta-dex and IL-2 resulted in a markedly heterogeneous increase in Ig secretion, which varied from 3-fold, as mediated by clone PKO 56, to 15-fold, as induced by clone PKO 101. The other NK cells showed intermediate levels of Ig induction. Furthermore, while addition of as few as 0.04% of PKO 101 cells stimulated significant increases and 1% induced near maximum Ig production, a 3% addition of PKO 56 cells was required for significant enhancement of Ig secretion. Supernatant material collected from the NK clones mediated Ig production at levels that mirrored the induction by the corresponding cells. Cytokine analysis showed that while all members of the NK panel produced IFN-gamma only two secreted granulocyte macrophage colony stimulating factor and that the levels of Ig induction mediated by the NK clones correlated only with their levels of IFN-gamma secretion. Culture of B and NK cells in the presence of anti-IFN-gamma demonstrated that IFN-gamma was the critical cytokine in NK-induced Ig production. These findings establish heterogeneity in the ability of NK cells to increase Ig secretion in vitro and show that NK-produced IFN-gamma is an important factor in determining this heterogeneity. (+info)
Control of IBMIR Induced by Fresh and Cryopreserved Hepatocytes by Low Molecular Weight Dextran Sulfate Versus Heparin
Rapid destruction of hepatocytes after hepatocyte transplantation has hampered the application of this procedure clinically. The instant blood-mediated inflammatory reaction (IBMIR) is a plausible underlying cause for this cell loss. The present study was designed to evaluate the capacity of low molecular weight dextran sulfate (LMW-DS) to control these initial reactions from the innate immune system. Fresh and cryopreserved hepatocytes were tested in an in vitro whole-blood model using ABO-compatible blood. The ability to elicit IBMIR and the capacity of LMW-DS (100 mu g/ml) to attenuate the degree of activation of the cascade systems were monitored. The effect was also compared to conventional anticoagulant therapy using unfractionated heparin (1 IU/ml). Both fresh and freeze thawed hepatocytes elicited IBMIR to the same extent. LMW-DS reduced the platelet loss and maintained the cell counts at the same degree as unfractionated heparin, but controlled the coagulation and complement systems ...
Low molecular weight dextran sulfate unlike heparin abrogates the instant blood-mediated inflammatory reaction in pig-to-monkey...
The cell-seeded middle channel was filled with fluorescent dextran solution (10 mg | URAT1 inhibitor urat1inhibitor.com
The cell-seeded middle channel was filled with fluorescent dextran solution (10 mg/ml) in medium in the cell-seeded middle channel. Precisely 110 ml was
Dextran Market Globally - Herbon, Meito Sangyo, Tianxiangyuan and Polydex Pharm | Perfect Analyst
Global Dextran Research Report is segmented by leading Dextran manufacturers, regions, applications and Dextran type to provide all crucial details to the readers. A comprehensive study of Dextran market based on product portfolio, applications, cost, manufacturing processes involved in Dextran are evaluated at depth. In coming years Dextran market is slated to see more emerging players which will lead to tremendous Dextran development. Dextran Market growth, market scope, and Dextran revenue are cited in this report. In-depth study of Dextran market competition, developments, Dextran growth opportunities and factors limiting the market growth are analyzed in detail. All the fundamental market details like Dextran consumer volume, market size, supply/demand scenario, and Dextran gross margin analysis are covered in this report.. Global Dextran study will serve as a valuable guide for identifying business opportunities and making the strategic business decisions which will lead to profits in ...
Abstract P227: Cardiac Arrhythmias, Hemodynamic Instability and Death Following Low Volume 7.5% NaCl With 6% Dextran-70 or 10%...
Hemorrhagic shock was induced by removal of up to 50% blood volume over 20 min until mean arterial pressure (MAP) decreased to 35-40 mmHg. Animals were left in shock at 32°C for 60 min. Resuscitation was commenced with small boluss (0.3 ml or ~3% of shed blood) injected into the femoral vein and Lead II ECG, MAP and heart rate (HR) were monitored.. Results: 0.3 ml of 7.5% saline at resuscitation led to a drop in MAP to about 10 mmHg lasting for 4 min, increased to around 60 mmHg and then slowly declined to 40 mmHg over the next hour. No arrhythmias were detected. Curiously, 0.3 ml of 7.5% NaCl/6% Dextran-70 led to a 1.5 fold increase in the QRS amplitude, ventricular arrhythmias and cardiac instability after 10 min, and an increase in HR of 20 to 40 bpm. The MAP initially fell then quickly returned to 35-38 mmHg for ~4 min, increased to above 55 mmHg and stabilized at around 50 mmHg for 60 min. 0.3 ml of 7.5% NaCl/10% hetastarch resulted in a 63% mortality (5 of the 8 rats died from ...
Global Dextran Market 2018- Meito Sangyo, Jinyang Biological Pharmaceutical - xBox 360 Asylum
The Dextran Market 2018 Research Report studies an absolute and exhaustive study on Dextran industry volume, Market Share, Industry Trends, Dextran Growth appearances, the wide range of applications, Utilization ratio, Supply including demand analysis, production capacity, Price during the Forecast period from 2018 to 2023. High Use of Dextran in Food and Beverages Industry driving the market growth of Dextran .. The analysis report specified Global Dextran Market 2018 displays the intelligent study of Dextran market globally, accumulating on a complete analysis of the now and past historical details of Dextran market. The ambitious panorama view of the Dextran industry is also comprised in this research report.. Get Sample Report Pages Here: https://market.biz/report/global-dextran-market-2018/211706/#requestforsample. Competitive Study of Global Dextran Market 2017 Based on Key Vendors: Meito Sangyo, Jinyang Biological Pharmaceutical , Pharmacosmos, Polydex Pharm and PK Chemicals. Dextran ...
Dextran coating on and among fibers of polymer sponge scaffold for osteogenesis by bone marrow cells in vivo
Although hydroxyapatite is commonly used as a scaffold for bone regeneration, sponges may be suitable because of the adaptability to the defect. To use as a scaffold, the fiber of sponge would be coated with any adhesive to storage stem cells in the sponges. Fiber in the structure of commercially available sponges was coated by immersion in dextran solution and air dried. After seeding of rat bone marrow cells (rBMCs), the sponges were implanted subcutis of rats for estimate osteogenesis in vivo. The level of osteocalcin was 25.28 ± 5.71 ng/scaffold and that of Ca was 129.20 ± 19.69 μg/scaffold. These values were significantly high- er than those in sponges without dextran coating (p < 0.01). It was thought that rBMCs could be stored on the shelf by dextran deposition in the fiber of the sponge. In vivo examination, dextran induced osteogenesis by rBMCs in many spaces in the inner structure of the sponge.
Dextran CLIO Magnetic Nanoparticles - Amine | Luna Nanotech Canada
General InformationAmine-functionalized Dextran coated crosslinked iron oxide nanoparticles (CLIO-NH2) have 1-3 superparamagnetic Fe3O4 iron oxide cores (8-10 nm in diameter) imbedded within the matrix of dextran sugar strands of 40 kDa or 70 kDa size. Dextran strands are crosslinked to prevent their disassociation, ensuring long-term biological stability. Dextran surface has been functionalized with Amine NH2 groups. Features Highly biocompatible, non-toxic Long term stable under physiological conditions 40 kDa and 70 kDa dextran coats are available Highly magnetic Can be easily conjugated to NHS-activated ligands Applications In vitroand in vivomagnetic labels for cells and tissues Magnetic cell separation Probes for MRI Specifications Iron Oxide Core Diameter: 8 - 10 nm Hydrodynamic Diameter: 60 - 80 nm Polydispersity Index (PDI): < 0.25 Nanoparticle Charge: Between -3 and -0.3 mV Magnetization: 5 - 30 emu/g (room temperature) Shelf life: > 1 year (4°C storage) Supplied as liquid suspension
Interaction of dextran derivatives with lipid monolayers and the consequential modulation of the film properties | CIQUIBIC
Cámara CL & N Wilke, Chem. Phys. Lipids, 2017 Polysaccharides have been associated with various biological functions through their binding to membranes, but their specific role is still under debate. The aim of this work was to study the interaction of cationic and anionic polysaccharides with anionic and zwitterionic monolayers, at different subphase compositions, thus analyzing the influence of electrostatics on the interaction. The consequent effect of the polymer-lipid binding on the film properties was studied, with special interest in monolayer dynamics. The results indicate that electrostatic interactions play an important role in polymer-membrane affinity, and that the polymers formed a sub-layer, which increased the shear viscosity of the interface. The interacting polymer, even when it did not penetrate the lipid film, induced a polymer-like behavior of the monolayer regarding its dynamics: the whole film (polymer+lipid) became very viscous. As a consequence, the dynamic of the ...
Substitutes plasma, and other blood components
The dextran - solutions of the polysaccharides from cultures of several bacteria, their antigenic properties. The dextran may have varying degrees of polymerization and, consequently, different molecular weight; these can be obtained by plasma-substituting solutions for various applications. Solutions containing dextran with a high molecular weight, are used primarily as a means of hemodynamic, but with a lower molecular weight as a corrector of rheological properties of blood. When injected into the blood dextrans increase the oncotic pressure and increase the displacement of fluid from the tissues into the bloodstream. They increase the diuresis and thus the detoxification processes. Because in the body the partial hydrolysis of the dextrans are excreted mainly by the kidneys (renal failure is a limitation to their use ...
Dextran Definition, Definition of Dextran, Anagrams, and words that start with Dextran
Dextran definition, definition of dextran, Anagrams of dextran, words that start with Dextran, and words that can be created from dextran
Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network | Blood | American...
Access of plasma tracers to the core region is size dependent. (A) Representative photomicrographs showing Alexa-488-labeled albumin infused 25 minutes post-injury. The image at the left shows albumin fluorescence. The brightfield image on the right is overlaid with a pseudocolor image depicting albumin intensity within the hemostatic plug. The black line in the pseudocolor image outlines the P-selectin-positive area. A time-lapse video illustrating albumin penetration into this hemostatic plug is included in supplemental Video 3. (B) The graph shows the porosity measured using fluorescent albumin as a tracer for the shell and core regions. Values are mean ± SEM for n = 8 injuries from 4 mice; statistics were performed using a 2-tailed Student t test. (C) Photomicrographs showing representative hemostatic plugs 20 minutes post-injury following infusion of either 10-kDa dextran (Ci) or 70-kDa dextran (Cii). Images are pseudocolored to depict dextran concentration within the platelet mass (the ...
Dextran5 9004-54-0, China Dextran5 9004-54-0 Manufacturers, China Dextran5 9004-54-0 Suppliers - QILI
We,China Dextran5 9004-54-0 Suppliers and China Dextran5 9004-54-0 Manufacturers, provide Dextran5 9004-54-0 product and the products related with China Dextran5 9004-54-0 - QILI
Blue dextran for gel filtration - Alfa Chemistry
Blue dextran for gel filtration/ACM87915386 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Lineage Labeling of Zebrafish Cells with Laser Uncagable Fluorescein Dextran | Protocol (Translated to German)
Dieses Protokoll zeichnet ein Weg, um Etiketten und Spurenelemente das Schicksal der kleinen Gruppen von Zellen Zebrafischembryonen mit ...
NTNU Open: Towards Dextran-Based Block Polysaccharides
Carbohydrates covalently linked with other chemical species are termed glycoconjugates. They are important compounds in biology, and are involved in many processes, such as cell-cell interactions. Glycoconjugates can be prepared by conjugating a compound to the reducing end of a carbohydrate directly or by modification of the reducing end by a multifunctional compound which in a second step can be conjugated to other molecules. Chemically modified glycoconjugates with carbohydrates conjugated to multifunctional compounds, could provide a vast amount of possibilities for further conjugation, opening up for constructing novel biopolymer hybrid molecules, for example polysaccharide block copolymers.. The aim of this work was to investigate the suitability of two types of bifunctional molecules in ligations to the carbonyl group at the reducing end of dextran oligosaccharides, and thereby activating the dextran for further conjugation.. Dextran was first partially degraded by acid hydrolysis to ...
Dextran - Bellatorra skin care
Dextran is a glucan compound that is used in skin care products. Comprised of polysaccharide and glucose, its medicinal purposes include acting as an antithrombotic, reducing blood viscosity. A polysaccharide is a system of polymeric carbohydrate molecules comprised of long chains bound by sugar molecules. The ingredient has been found to deliver water-binding activity for the skin as well as several other benefits.. Louis Pasteur discovered Dextran as an antimicrobial product. Antimicrobials kill microorganisms and inhibit their growth. The glucan, which also has been used to reduce blood thickness, was listed by the World Health Organization as a Model Essential Medicine, a list of medicines that are considered to be necessary for basic health systems.. In healthcare, Dextran has many different uses. In surgery, the compound is used to reduce vascular thrombosis. It is also used for binding platelets. Dextran has also been used in eye drops, IV solutions, for binding, and to prevent oxidation ...
The effect of temperature on the viscosity characteristics of erythrocyte suspensions - IOS Press
The effect of temperature on the viscosity characteristics of erythrocytes suspended in plasma, serum, buffer and fibrinogen or dextran solutions and of the suspending phases have been compared. All the suspending phases obey the relationship η = A e
As previously shown (16-19), direct induction of apoptosis by Rituximab is very ineffective unless the antibody is hyper-cross-linked by secondary antibody or immobilized on plastic. The goal of the present work was to determine if higher valency preparations of Rituximab could be used to simulate hyper-cross-linking events using formulations that are applicable in vivo. This goal was achieved by the generation of a polymer of Rituximab that consisted of ∼5 immunoglobulins per dextran molecule. To show its potency in vitro and in vivo, the polymer preparation was compared with Rituximab monomer and with a previously published dimer (30), which showed some improved activity when tested in apoptosis assays. Our results clearly showed that the polymer is able to induce apoptosis of CD20+ human lymphoma cell lines directly on binding, distinguishing it from both the monomer and dimer preparations using the TUNEL assay (Rituximab, 3%; dimer, 3%; polymer, 58%; see Figs. 1B and 2B). These findings ...
Nucleosides like adenosine, uridine and their nucleotide derivatives (e.g. ATP and UTP) play important roles in many cellular functions, sometimes by acting as signalling molecules through binding to specific P2 nucleotide receptors. P2 receptors are subdivided into P2X and P2Y subfamilies, the latter of which are G-protein coupled receptors. P2Y receptors and nucleoside transporters have been detected in human and rat lungs, where they mediate effects of interest in airway diseases. The aim of this study was to investigate whether uridine has any anti-inflammatory properties in an asthma-like animal model of lung inflammation.. The Sephadex-induced lung inflammation model in Sprague-Dawley rats was chosen mainly due to its localised inflammatory response and uridines limited oral bioavailability. The dextran beads, with or without the addition of uridine, were instilled intratracheally into the lungs, which were excised and examined after 24 h.. Sephadex alone led to massive oedema and ...
Assessing the Permeability of Engineered Capillary Networks in a 3D Culture
Many pathologies are characterized by poor blood vessel growth and reduced nutrient delivery to the surrounding tissue, introducing a need for tissue engineered blood vessels. Our lab has developed a 3D co-culture method to grow interconnected networks of pericyte-invested capillaries, which can anastamose with host vasculature following implantation to restore blood flow to ischemic tissues. However, if the engineered vessels contain endothelial cells (ECs) that are misaligned or contain wide junctional gaps, they may function improperly and behave more like the pathologic vessels that nourish tumors. The purpose of this study was to test the resistance to permeability of these networks in vitro, grown with different stromal cell types, as a metric of vessel functionality. A fluorescent dextran tracer was used to visualize transport across the endothelium and the pixel intensity was quantified using a customized MATLAB algorithm. In fibroblast-EC co-cultures, the dextran tracer easily penetrated
Dextan Conjugates | Thermo Fisher Scientific - US
Typically employed for tissue sections, in vivo neurons, and cultured cells, 3,000 MW dextrans are used to trace fine neuron projections and investigate gap junctions; 10,000 MW dextrans have slower distribution and longer cellular retention and do not cross gap junctions. The staining pattern produced by most of these labeled dextran products is lysine fixable.
Figure 8: Imaging of phagocytic cells with iron oxide-enhanced MR imaging. (A) USPIO and DOTA-Gd-enhanced MR imaging of EAE rats. A periventricular lesion shows DOTA-Gd enhancement but not USPIO uptake. Vice versa, a ventral lesion shows USPIO uptake but no DOTA-Gd enhancement. No enhancement is seen in a control animal. (B) Pre-Gd T2 MRI on a MS patient demonstrates multiple lesions, and while there is a DTPA-Gd and USPIO enhancing lesions (arrow), there also is an USPIO-uptake-only lesion (arrowhead). (C) Spatiotemporal profile of USPIO uptake in the ischemic rat brain over 7 days. While USPIO uptake is first seen in the periphery of the infarct (ADC map), uptake becomes more central on the following days, while no uptake is seen on day 7. (D) Comparison of USPIO and DTPA-Gd in a patient with ischemic stroke. Diffusion-weighted imaging displays ischemic area. Areas of USPIO uptake are clearly different from gadolinium enhancement. (Modified from Rausch et al. [10,171], Vellinga et al.  ...
Dextran, low molecular weight Use During Pregnancy | Drugs.com
Advice and warnings for the use of Dextran, low molecular weight during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out
Rhod-2 dextran conjugate *Low affi... - 20450 AAT Bioquest - Antibo...
Product Rhod-2 dextran conjugate *Low affinity with MW 3000* From AAT Bioquest - R-phrase: R20, R21, R22;H-Phrase: H303, H313, H333;Symbol for dangerous compounds: Xn;UNSPEC Code: 12352200
Global Dextran Market Professional Survey Report 2017
Dextran market report added by qyresearchgroups.com. In this Report includes best market price, trends, Growth, Forecast, Analysis, demand & Overview.
Characterization of the Dextran Produced by Leuconostoc mesenteroides from Date Fruit Extract
In the present study, the production of dextran from date extract and sucrose as carbon sources by the bacterium Leuconostoc mesenteroides NRRL B512 (f) was investigated. In comparison to blue dextran (Mw≈2000 Da), dextran molecular weight was reduced (Mw2000 KDa). Flow behavior indices of dextran solutions from date extracts were investigated and rheological parameters were evaluated at concentrations of 1.5, 2.5, 5, together with 10% total solids at 25˚C using a Brookfield rotational viscometer as well as a cone and plate geometry. The experimental results followed the power law model for the best fit and the values of flow behavior index (n) were less than unity (0.49 .93) at all concentrations, revealing the shear thinning nature of the produced dextran. Furthermore, dependence of apparent viscosity on concentration was confirmed using the power law model.
Release of recombinant human interleukin-2 from dextran-based hydrogels | Drug Delivery Technology
In this study, the release of recombinant human interleukin-2 (rhlL-2) from methacrylated dextran (dex-MA) and (lactate-)hydroxyethyl methacrylated dextran (dex-(lactate-)HEMA) hydrogels with varying crosslink density was investigated. Hydrogels derived from dex-MA are stable under physiological conditions (pH 7 and 37degreesC), whereas dex-HEMA and dex-lactate-HEMA hydrogels degrade due to the presence of hydrolytically sensitive esters in the crosslinks of the gels. The protein release profiles both the non-degradable and degradable dextran-based hydrogels showed that with increasing crosslink density of the get, the release of rhIL-2 decreases. From dex-MA hydrogels with an initial water content above 70%, the rhIL-2 release followed Fickian diffusion, whereas from gels with an initial water content of 70% or lower the protein was fully entrapped in the hydrogel meshes. In contrast with non-degradable dex-MA hydrogels, degradable dex-lactate-HEMA gels with comparable network characteristics ...
Effects of Dextran-40 on Urine Flow | Postgraduate Medical Journal
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Study of starch granules swelling by the blue dextran method and by microscopy
2004. Study of starch granules swelling by the blue dextran method and by microscopy. 2004. Elizabeth Contreras López, Arnaud Rolée and Martine Le Meste. Starch/Starke, 56, 576-581. ...
Effect of macromolecular crowding on the stability of monomeric glutaredoxin 2 and dimeric glutathione transferase A1-1
KUHNERT, Diane C.; GILDENHUYS, Samantha y DIRR, Heini W.. Effect of macromolecular crowding on the stability of monomeric glutaredoxin 2 and dimeric glutathione transferase A1-1. S. Afr. j. sci. [online]. 2008, vol.104, n.1-2, pp.76-80. ISSN 1996-7489.. The effect of macromolecular crowding on the structure and stability of monomeric glutaredoxin 2 (Grx2) and its homodimeric structural homologue human glutathione transferase A1-1 (hGST A1-1) was investigated using dextran 70 as crowding agent. Far-UV circular dichroism and fluorescence spectroscopic data indicated that repulsive steric interactions between the proteins and dextran (50-300 mg/ml) had little effect on the global structures of the native proteins. Urea-induced unfolding of both proteins was reversible (recoveries of ,80%) at low dextran concentrations (,100 mg/ml) but resulted in significant losses in refolding recoveries at higher levels of dextran, due to aggregation. The two-state global unfolding processes of Grx2 and hGST ...
dextran (high molecular weight) | Cigna
High-molecular weight dextran is a plasma volume expander made from natural sources of sugar (glucose). It works by restoring blood plasma lost through severe bleeding. Severe blood loss can decrease oxygen levels and can lead to organ failure, brain damage, coma, and possibly death. Plasma is needed to circulate red...
Fusion Pore Dynamics and Insulin Granule Exocytosis in the Pancreatic Islet | Science
We next probed expansion of the fusion pore with tracers of various molecular sizes (12). The smaller molecules, SRB (∼1.4 nm) and 3-kD dextran (∼4 nm), permeated earlier than did 10-kD dextran (∼6 nm), whereas 70-kD dextran (∼12 nm) permeated later (Fig. 4B, C, and E). As expected, two 10-kD dextran tracers permeated simultaneously (Fig. 4D). The observation that the larger tracers began to permeate abruptly after the smaller tracers suggests that the expanding pore has a well-defined geometry. Moreover, closure of the SRB-permeable pore was detected without opening of the 10-kD dextran-permeable pore in 7% (11/164) of SRB events, which were characterized by smaller increases in SRB fluorescence (12) that ceased shortly after pore opening (Fig. 4F). Such closure was also detected in 2% (2/84) of 3-kD dextran events before 10-kD dextran events, but not in 10-kD dextran events before 70-kD dextran events (n = 62). Thus, the fusion pore was semistable when the pore diameter was between 1.4 ...
Intramolecular and Intermolecular Association during Chemical Cross-Linking of Dilute Solutions of Different Polysaccharides...
In this work, intramolecular and intermolecular associations under the effect of shear flow of dilute aqueous alkaline solutions of dextan, hydroxyethylcellulose (HEC), and the hydrophobically modified analogue (HM-2-HEC) in the presence of a chemical cross-linking agent were characterized with the aid of viscometry and rheo-small angle light scattering (rheo-SALS) methods. The picture that emerges at short times during the cross-linking reaction at a constant shear rate is that HEC coils contract because of intramolecular cross-linking; whereas the HM-2-HEC species show an incipient association and the dextran molecules are unaffected due to their compact structures. At longer times, interchain cross-linking of the polymer promotes the growth of large flocs, which are disrupted by shear forces when they are sufficiently large. The delicate interplay between intramolecular and intermolecular association is governed by factors such as the magnitude of the shear rate, the cross-linking agent ...
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Most recent papers with the keyword Heparin in kawasaki | Read by QxMD
A conjugate of polyL-lysine (PLL) with unsulfated dextran produced by reductive amination was found to have remarkable anti-HIV-1 activity against both the macrophage-tropic R5 virus Ba-L and T-cell line tropic X4 virus IIIB strains, although neither PLL nor dextran has such activity. The conjugate is a pseudoproteoglycan (pseudoPG) that simulates the structure of a proteoglycan. Conjugation with dextran was found to produce an antiviral effect in three kinds of assay systems including a human CD4(+) T-cell line, and the pseudoPG synthesized using 10 kDa PLL and 10 kDa dextran showed EC(50) 4-40 times lower than that of sulfated dextran or heparin against Ba-L and EC(50) equal to that against IIIB, indicating that PLL-dextran (PLL-Dex) was more effective against R5 virus than sulfated polysaccharides ...
October | 2020 | bcl-2 inhibitors
Methods: Twenty patients undergoing endovascular stenting for abdominal aortic aneurysm were randomized to receive 100 mL of 10% dextran-40. orsalinc, over I hour, during their operation in addition to heparin. Mood samples were taken preoperatively, intraoperatively (immediately after operative procedure), and 24 hours postoperatively. Thrombi were formed in a Chandler loop and used to assess endogenous fibrinolysis over 24 hours, measured as the fall in thrombus weight, and the release of fluorescently labelled fibrinogen from the thrombus. Plasma samples were analyzed for markers of fibrinolysis; plasmin-antiplasmin (PAP), PAI-1, and t-PA, and for functional von Willebrand factor (vWF). Platelet response to thrombin and other agonists was measured by flow cytometry.. Results: S63845 supplier Thrombi formed ex vivo front the intraoperative blood samples from the dextran-treated patients. exhibited significantly greater fibrinolysis vs preoperative samples, seen both as a significantly greater ...
Iron Dextran Injection
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Iron Dextran (Infed) - Side Effects, Interactions, Uses, Dosage, Warnings | Everyday Health
Find everything you need to know about Iron Dextran (Infed), including what it is used for, warnings, reviews, side effects, and interactions. Learn more about Iron Dextran (Infed) at EverydayHealth.com.
ellipticine-polyaldehyde dextran Summary Report | CureHunter
ellipticine-polyaldehyde dextran: prepared with acid hydrazides as the hydrazone; offers a method for drug loading via dextran conjugates to monoclonal antibodies
Dextran from Leuconostoc mesenteroides average mol wt 48,000-90,000 | Sigma-Aldrich
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Calcium entry blockade prevents leakage of macromolecules induced by ischemia-reperfusion in skeletal muscle. | Circulation...
Calcium kinetics and its intracellular mobilization are important in all biological processes. We used verapamil to examine the effect of calcium entry blockade on microvascular transport of macromolecules in ischemia-reperfusion injury. The rat cremaster muscle was splayed, placed in a Lucite intravital chamber, and suffused with bicarbonate buffer. The clearance of fluorescein isothiocyanate-conjugated dextran (FITC-dextran 150) was measured as an index of microvascular transport. After determination of baseline data (clearance of FITC-dextran 150, 3.0 +/- 0.5 microliters/5 min/g), the muscle was made ischemic for 2 hours by clamping its vascular pedicle and subsequently was reperfused for 2 hours. Ischemia-reperfusion produced a marked increase in FITC-dextran clearance. After a peak of 12 +/- 2-fold increase observed in the first 15 minutes into reperfusion, FITC-dextran 150 clearance decreased in magnitude and stabilized at about sixfold above baseline. Verapamil did not change the baseline ...
Bioline International Official Site (site up-dated regularly)
There are several experimental models describing in vivo eosinophil (EO) migration, including ip injection of a large volume of saline (SAL) or Sephadex beads (SEP). The aim of this study was to investigate the mechanisms involved in the EO migration in these two models. Two consecutive injections of SAL given 48 hr apart, induced a selective recruitment of EO into peritoneal cavity of rats, which peaked 48 hr after the last injection. SEP, when injected ip, promoted EO accumulation in rats. The phenomenom was dose-related and peaked 48 hr after SEP injection. To investigate the mediators involved in this process we showed that BW A4C, MK 886 and dexamethasone (DXA) inhibited the EO migration induced by SAL and SEP. To investigate the source of the EO chemotactic factor we showed that mast cells, macrophages (MO), but not lymphocytes, incubated in vitro in presence of SAL released a factor which induced EO migration. With SEP, only mast cells release a factor that induced EO migration, which was ...
INFED (iron dextran injection) | Side Effects, Adverse Reactions | Healthgrades.com
Side Effects for INFED (iron dextran injection) are also known as adverse reactions. Below is a summary of known side effects for INFeD.
Search Results | Journal of Experimental Medicine | Rockefeller University Press
Antilevan, antidextran, antiteichoic acid, anti-A and normal γG, all isolated from a single human, as well as pooled γG and γM, were analyzed for amino acid content. Differences ranging from 7 to 32 residues were found among these antibodies in glycine, valine, leucine, tyrosine, arginine, lysine, and threonine content. These conspicuous differences in amino acid composition were not correlated with the Gm type of these antibodies. Hydroxylysine was found in two of the four antibodies, antidextran and antiteichoic acid, and in γM- immunoglobulin. No hydroxylysine was found in γG- globulins. These findings probably account for discrepancies in the literature concerning the occurrence of this residue in antibody protein ...
The influence of temperature on the volume effect of dextran 70 | SpringerLink
The reliability of an infusion of 500 ml cold or room temperature 6% dextran 70 in normal saline as a volume expander was studied in eleven subjects after removal of 500 ml blood. Changes in blood...
Pterins as Sensors of Response to the Application of Fe3 -Dextran in Piglets - pdf descargar
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PHOTREXA VISCOUS (riboflavin 5-phosphate in 20% dextran ophthalmic kit) | Dosage and Administration | Healthgrades.com
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Sulfation of dextran with chlorosulfonic acid in organic solvents, Russian Journal of Applied Chemistry | 10.1134...
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Transfection Mediated by DEAE-Dextran: High-Efficiency Method
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Browsing Leicester School of Pharmacy by Subject Chord length distribution
One step aqueous melt-crystallization and in situ granulation was utilized to produce ibuprofen-cationic dextran [diethylaminoethyl dextran (Ddex)] conjugate crystanules without the use of surfactants or organic solvents ...
Medical Express - Use of small volume hypertonic acetate dextran during aortic occlusion in pigs: assessment of blood flow and...
MedicalExpress will run as a continuous flow journal, a characteristic shared by no other Brazilian periodical. Accepted articles will be submitted to language polishing, composition, and submitted to authors for final approval. As soon as this is completed, articles will be made public. It is expected that accepted articles would be published approximately 30 days after acceptance.
Labelling of polypeptides with Technetium-99m using dextran spacer.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. ...
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NTA chip creation - OpenWetWare
The purpose of this protocol is to provide a detailed method for the creation of an NTA surface on top of a carboxymethylated dextran chip. This protocol specifically focuses on the BiaCore CM5 chip, but could be adapted to other similar chips. ...
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What are the four types of macromolecules? | Reference.com
The four types of macromolecules are nucleic acids, proteins, carbohydrates and lipids. These macromolecules are large molecules that make up most of the bodies of living things. They consist of...
Experimental studies in rats using neutral dextran". Biophys. J. 15 (9): 887-906. Bibcode:1975BpJ....15..887C. doi:10.1016/ ...
DEAE-Dextran (DEAE-D) is a positively charged dextran derivative that can be used for vaccine production, gene therapy, protein ... "DEAE-Dextran" (PDF). GE Life Sciences. Amersham Biosciences. Archived from the original (PDF) on 11 June 2016. Retrieved 11 May ... Cellulose, dextran, agarose, and other insoluble complexes are unaffected because they compose inert matrices, hence why they ... Gulick, Tod (2003). "Transfection Using DEAE-Dextran". Current Protocols in Cell Biology. 19: 20.4.1-20.4.10. doi:10.1002/ ...
Matsuda, Kazuo; H. Wanatabe; K. Fujimoto; K. Aso (1961). "Isolation of Nigerose and Kojibiose from Dextrans". Nature. 191 (4785 ... but is also readily extracted from the dextrans found in rice molds and many other fermenting microorganisms, such as L. ... Isolation of nigerose from the acetolysate of a dextran produced by Leuconostoc mesenteroides NRRL B-421". Tohoku Journal of ...
Plasma expanders are natural or synthetic substances (dextran, albumin...), that are able to retain liquid in the vascular ...
... is a cross-linked dextran gel used for gel filtration. It was launched by Pharmacia in 1959, after development work by ... The name is derived from separation Pharmacia dextran. It is normally manufactured in a bead form and most commonly used for ... Fractionation Range of Globular Proteins and Dextrans (Da). Ion-exchange chromatography. PEGylation Size exclusion ... filtration and chromatographic media are composed of macroscopic beads synthetically derived from the polysaccharide dextran. ...
Sawai T, Toriyama K, Yano K (January 1974). "A bacterial dextranase releasing only isomaltose from dextrans". Journal of ...
Adelaide Steamship Company
Dextran Pty Ltd - like Vaniro, another AdSteam subsidiary. Dextran is the owner of IEL. During the 1980s, AdSteam instigated a ... AdSteam investment company Dextran purchased IEL from Brierley Investments in November 1989. Dextran was one-third each owned ... and Dextran Pty Limited (1/3) which in turn owns Industrial Equity Limited." Metropolitan Wholesale Meat Company Limited ...
Lopez, A; Monsan, P (1980). "Dextran synthesis by immobilized dextran sucrase". Biochimie. 62 (5-6): 323-329. doi:10.1016/S0300 ...
The polymer dextran is one prominent example of a very useful polymer. It is produced at commercial scale for uses in ... Robyt JF, Yoon SH, Mukerjea R (December 2008). "Dextransucrase and the mechanism for dextran biosynthesis". Carbohydrate ...
Flodin worked with dextran research at Pharmacia. In 1957, Porath discovered that columns filled with dextran gel could be used ... A short time thereafter, Pharmacia offered the product Sephadex (Separation Pharmacia Dextran) on the market. Porath also ...
Examples include chitosan, hyaluronic acid, and dextran. Chitosan, a frequently used example, is cationic. Since DNA is ...
Hehre EJ, Hamilton DM (1953). "The biological synthesis of dextran from dextrins". J. Biol. Chem. 192: 161-174. Biology portal ... Other names in common use include dextrin 6-glucosyltransferase, and dextran dextrinase. Hehre EJ (1951). "Enzymic synthesis of ... "Bacterial conversion of dextrin into a polysaccharide with the serological properties of dextran". Proc. Soc. Exp. Biol. Med. ...
Nerve guidance conduit
Dextran is a polysaccharide derived from bacteria; it is usually produced by enzymes from certain strains of leuconostoc or ... Cross-linked dextran hydrogel beads have been widely used as low protein-binding matrices for column chromatography ... However, it has not been until recently that dextran hydrogels have been investigated in biomaterials applications and ... An advantage of using dextran in biomaterials applications include its resistance to protein adsorption and cell-adhesion, ...
"The Global Leader in Pharmaceutical Dextran , Pharmacosmos Dextran". www.dextran.com. Retrieved 2020-11-17.. ... It has a lower incidence of dextran-induced analphylaxis than older dextran-based products, although still requires a test dose ... The generic name for Uniferon is iron dextran. Its approved by health authorities in Europe, Asia and in the U.S. by Food and ... The generic name of Cosmofer is low molecular weight iron dextran. Cosmofer was approved in 2001 and is available in more than ...
"DER ARZNEIMITTELBRIEF: Infusionstherapie beim idiopathischen Hörsturz? Dextran Dextran Hörsturz Hydroxyethylstärke ...
Such polysaccharides include pectin, dextran, agar, and xanthan. Sugar content is commonly measured in degrees brix. The term ...
Lactic acid bacteria
LAB are able to synthesize levans from sucrose, and dextrans from glucose. Glucans, such as dextran, enable bacteria to adhere ...
... s composed of dextran have been developed for imaging tumor-associated macrophages with radionuclides and targeting the ... "89Zr-Labeled Dextran Nanoparticles Allow in Vivo Macrophage Imaging". Bioconjugate Chemistry. 22 (12): 2383-9. doi:10.1021/ ...
... autoactivation by dextran sulfate. Circular dichroism, fluorescence, and ultraviolet difference spectroscopic studies". The ...
Chemically, it is an ether of dextran and diethylethanolamine. Drugs.com: Colextran v t e. ...
Walker GJ, Pulkownik A (July 1973). "Degradation of dextrans by an alpha-1,6-glucan glucohydrolase from Streptococcus mitis". ...
Glycoside hydrolase family 49
Dextranase hydrolyses alpha-1,6-glycosidic bonds in dextran polymers. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, ...
Intravenous iron infusion
Large dextran molecules did however have a connection to anaphylaxis. As such an infusion of Imferon was not recommended to ... Iron dextran attributed to at least thirty-one deaths across the United States and Europe, ferric gluconate had no casualty ... Later, in 1954 the use of iron dextran became popular and a product called Imferon emerged. Release of free bioactive iron was ... The use of low molecule weight iron dextran was common place for renal dialysis patients and due to its success usage increased ...
Normally it is coated in carboxymethyl dextran or similar compound. The refractive index at the flow side of the chip surface ...
Not to be confused with Dextran.. Dextrins are a group of low-molecular-weight carbohydrates produced by the hydrolysis of ...
Bradford protein assay
... and dextran using the Bradford method". Analytical Biochemistry: Methods in the Biological Sciences. 395 (1): 108-110. doi: ...
One possibility is the filtration of macromolecules (often dextran, polyethylene glycol or albumin), another is measurement of ... A vivid characterization is to measure the rejection of dextran blue or other colored molecules. The retention of bacteriophage ...
Rozenfel'd, E.L.; Lukomskaya, I.S. (1956). "[The hydrolysis of 1:6 bonds of dextran by animal tissues.]". Biokhimiya. 21 (3): ... Dextranase (EC 188.8.131.52, dextran hydrolase, endodextranase, dextranase DL 2, DL 2, endo-dextranase, alpha-D-1,6-glucan-6- ... This enzyme catalyses the following chemical reaction Endohydrolysis of (1->6)-alpha-D-glucosidic linkages in dextran Bailey, R ...
T-3040, which catalyzes the conversion of dextran to cyclic isomaltooligosaccharides". FEBS Lett. 345: 135-138. doi:10.1016/ ... dextrans). Oguma T, Horiuchi T, Kobayashi M (1993). "Novel Cyclic dextrins, Cycloisomaltooligosaccharides, from Bacillus sp. T- ...
Molekul - Vikipedija, slobodna enciklopedija
Experimental studies in rats using neutral dextran". Biophys J. 15 (9): 887-906. Bibcode:1975BpJ....15..887C. PMC 1334749 . ...
Dextran - Wikipedia
Dextran also increases blood sugar levels. Dextran can be used in an ATPS for PEGylation Dextran is used in ... Resource on dextran properties and structure of dextran polymers Dextrans at the US National Library of Medicine Medical ... Dextran has also been used in bead form to aid in bioreactor applications. Dextran has been used as an immobilization agent in ... Dextrans are available in multiple molecular weights ranging from 3,000 Da to 2,000,000 Da. The larger dextrans (>60,000 Da) ...
Dextran 1 - Wikipedia
Dextran 1 is composed of a small fraction (1 kilodalton) of the entire dextran complex. This is enough to bind anti-dextran ... Thereby, dextran 1 binds up antibodies towards dextran without causing the immune response, leaving less antibodies left to ... Dextran 1 is a hapten inhibitor that greatly reduces the risk for anaphylactic reactions when administering dextran. ... Nine years of post-marketing surveillance of dextran 1". Annales Françaises dAnesthésie et de Réanimation. 12: 219-22. doi: ...
Iron Dextran Injection: MedlinePlus Drug Information
Iron Dextran Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before receiving iron dextran injection,. *tell your doctor and pharmacist if you are allergic to iron dextran injection; any ... Iron dextran injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: * ... Iron dextran injection is used to treat iron-deficiency anemia (a lower than normal number of red blood cells due to too little ...
DEXTRAN || Skin Deep® Cosmetics Database | EWG
Blue Dextran Loading Solution, 3ml
To protect your privacy, your account will be locked after 6 failed attempts. After that, you will need to contact Customer Service to unlock your account.. You have 4 remaining attempts.. You have 3 remaining attempts.. You have 2 remaining attempts.. You have 1 remaining attempt.. Contact Customer Service ...
iron dextran | Cigna
Iron dextran is used to treat iron deficiencies and iron deficiency anemia (low red blood cells). Iron dextran may also be used ... Iron dextran is a form of the mineral iron. Iron is important for many functions in the body, especially for the transport of ... How is iron dextran given?. Iron dextran is injected into a vein through an IV. You may be shown how to use an IV at home. Do ... What is iron dextran?. Iron dextran is a form of the mineral iron. Iron is important for many functions in the body, especially ...
Iron dextran Side Effects in Detail - Drugs.com
Learn about the potential side effects of iron dextran. Includes common and rare side effects information for consumers and ... Applies to iron dextran: injection solution. Along with its needed effects, iron dextran may cause some unwanted effects. ... Applies to iron dextran: injectable solution. Hypersensitivity. Uncommon (0.1% to 1%): Anaphylactoid reactions (including ... DexFerrum (iron dextran)." American Regent Laboratories Inc, Shirley, NY. 2. Cerner Multum, Inc. "UK Summary of Product ...
Iron Dextran Injection Drug Shortage Notice - Drugs.com
DailyMed - IRON HYDROGENATED DEXTRAN- iron injection
iron dextran 100 MG per 1 ML Injectable Solution. SY. 3. 311143. iron-dextran complex (iron 100 MG/ML) Injectable solution. SY ... IRON HYDROGENATED DEXTRAN- iron injection. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader ... IRON HYDROGENATED DEXTRAN INJECTION is a sterile solution containing 100 mg of elemental iron per mL, stabilized with a low ... IRON HYDROGENATED DEXTRAN- iron injection. If this SPL contains inactivated NDCs listed by the FDA initiated compliance action ...
Dextran - DrugBank
... and this activity is used commercially to obtain dextran.Dextran 40 is a sterile, nonpyrogenic preparation of low molecular ... Dextran 75 is a complex branched glucan with an average molecular weight 75000 Daltons. It is produced from certain bacteria ... The chains can be composed of about 200,000 glucose units.Many bacteria, like Leuconostoc, can synthesize dextran from sucrose ... When labelled with technetium Tc99m, dextran 75 is intravenously administered as an imaging agent to detect and diagnose ...
fluorescein isothiocyanate dextran | China-Mainland | Sigma-Aldrich
As the MW increases, dextran molecules attain greater symmetry.7,12,13 Dextrans with MW of 2,000 to 10,000, exhibit the ... 10 Lower MW dextrans will exhibit slightly less branching4 and have a more narrow range of MW distribution.11 Dextrans with MW ... Sigma dextrans are derived from Leuconostoc mesenteroides, strain B 512. Various MW are produced by limited hydrolysis and ... The excitation maximum of FITC-dextran is 490 nm. The emission maximum is 520 nm.11 The fluorescence increases with pH and is ...
dextran (high molecular weight) | Cigna
Dextran de alto peso molecular es un expansor de volumen plasmático hecho de fuentes naturales de azúcar (glucosa). Funciona ... Qué es dextran de alto peso molecular?. Dextran de alto peso molecular es un expansor de volumen plasmático hecho de fuentes ... Cómo se administra dextran de alto peso molecular?. Esta medicina se inyecta en una vena a través de una inyección intravenosa ... No se sabe si dextran de alto peso molecular pasa a la leche materna o si le puede hacer daño al bebé lactante. Dígale a su ...
Iron Dextran Has Highest Adverse Effects Rate of All IV Iron Products
Reported rates of adverse effects from iron dextran in Europe and North America over a 6-year period were much higher than for ... In addition, the difference in AE rates for iron dextran might reflect the higher use of high-molecular-weight iron dextran in ... Cite this: Iron Dextran Has Highest Adverse Effects Rate of All IV Iron Products - Medscape - Jul 02, 2010. ... Only low-molecular-weight (LMW) iron dextran has been sold in Europe since 2005. For North America, the figure represents the ...
Iron Dextran (Injection Route) Description and Brand Names - Mayo Clinic
Papain Activity in Dextran Solution for Keratin Hydrolysis
The concentration of dextran was ranged to 100 g/L. In the increasing concentration of dextran, the activity of papain ... Even in concentrated dextran solution, keratin powder was possible to be hydrolyzed at the high efficiency. ... This study includes the papain activity in the high concentrated dextran solution for keratin hydrolysis. Papain is the ... The concentration of dextran was ranged to 100 g/L. In the increasing concentration of dextran, the activity of papain ...
Iron Dextran Complex (IARC Summary & Evaluation, Supplement7, 1987)
Dextran iron complex *Iron dextran injection *Ironorm injection Last updated: 3 March 1998 See Also: Toxicological ... intramuscularly administered iron-dextran complex. B. Evidence for carcinogenicity to animals (sufficient). Iron-dextran ... IRON DEXTRAN COMPLEX. (Group 2B). For definition of Groups, see Preamble Evaluation. Supplement 7: (1987) (p. 226) CAS No.: ... Iron dextran complex is possibly carcinogenic to humans (Group 2B).. References. 1. IARC Monographs, 2, 161-178, 1973. 2. ...
Characterization of a novel dextran produced by Gluconobacter oxydans DSM 2003. - PubMed - NCBI
Characterization of a novel dextran produced by Gluconobacter oxydans DSM 2003.. Wang S1, Mao X, Wang H, Lin J, Li F, Wei D. ... The dextran was purified by size exclusion chromatography, and the structure was determined by Fourier transform infrared ... Based on the spectral data, we found that the dextran contained only D-glucose residues. The ratio of nonreducing end ... A novel water-soluble dextran was synthesized from maltodextrin by cell-free extract of Gluconobacter oxydans DSM 2003. ...
Should we still use iron dextran in hemodialysis patients? - PubMed - NCBI
dextran, high molecular weight
High-molecular weight dextran is a plasma volume expander derived from natural sources of sugar (glucose). It works by ... Dextran is given as an injection through a needle placed into a vein. For a hysteroscopy procedure, dextran is placed into the ... What other drugs will affect high-molecular weight dextran?. Before you receive dextran, tell your doctor if you are also using ... What is high-molecular weight dextran?. High-molecular weight dextran is a plasma volume expander derived from natural sources ...
Transient transfection of Cos-7 (electroporation v DEAE dextran)
Hi, , , does anyone have any experience with transient transfection of Cos-7 , cells? I have attempted a DEAE-dextran/ ... Transient transfection of Cos-7 (electroporation v DEAE dextran). Rick Nicholson R.Nicholson at cfi.unsw.edu.au Tue Feb 18 22: ... Next message: Transient transfection of Cos-7 (electroporation v DEAE dextran) * Messages sorted by: [ date ] [ thread ] [ ... Next message: Transient transfection of Cos-7 (electroporation v DEAE dextran) * Messages sorted by: [ date ] [ thread ] [ ...
Production of dextran in transgenic potato plants. | Sigma-Aldrich
The dextran concentration appeared two times higher in the Kardal (about 1.7 mg/g FW) than in the amf transformants. No dextran ... Production of dextran in transgenic potato plants.. [Géraldine A Kok-Jacon, Jean-Paul Vincken, Luc C J M Suurs, Denong Wang, ... The production of dextran in potato tubers and its effect on starch biosynthesis were investigated. The mature dextransucrase ( ... Kardal and the amylose-free (amf) mutant), dextrans were detected by enzyme-linked immunosorbent assay (ELISA) in tuber juices ...
The influence of temperature on the volume effect of dextran 70 | SpringerLink
... dextran 70 in normal saline as a volume expander was studied in eleven subjects after removal of 500 ml blood. Changes in blood ... Dextran Blood Volume Volume Effect Massive Transfusion Autologous Plasma The experiments were carried out in the Department of ... The reliability of an infusion of 500 ml cold or room temperature 6% dextran 70 in normal saline as a volume expander was ... Die Temperatur der Infusionslösung beeinflußt im Bereich von 4-20°C den Volumeneffekt von Dextran 70 bei hypovolämischen ...
Antifibrous action of aldehyde-dextran modified superoxide dismutase in experimental silicosis | SpringerLink
Oral in vivo Bactofection in Dextran Sulfate Sodium Treated Femal...: Ingenta Connect
Plasma concentrations of Il1, Il6 were lower in the treatment groups than in the dextran sodium sulfate group. However, dextran ... Keywords: BACTOFECTION; DEXTRAN SULFATE SODIUM INDUCED COLITIS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; PLASMID GENE THERAPY; ... Although some parameters showed a tendency to improve, the inflammation caused by administration of 4% dextran sodium sulfate ... Oral in vivo Bactofection in Dextran Sulfate Sodium Treated Female Wistar Rats ...
Dextran | Springer for Research & Development
DEAE-Dextran-Mediated Delivery | Thermo Fisher Scientific - AU
... dextran tightly associates with the backbone of the nucleic acid allowing it to adhere to the cell membrane and enter the ... Diethylaminoethyl (DEAE)-dextran is a polycationic derivative of the carbohydrate polymer dextran, and it is one of the first ... Nucleic acid-DEAE-dextran complexes are formed via electrostatic interactions between the polymer and phosphate backbone of the ... Nucleic acid-DEAE-dextran complexes are formed via electrostatic interactions between the polymer and phosphate backbone of the ...
Polysaccharides and Dextran
Iron Dextran Injection
Browse fuzing.com to find iron dextran injection sellers, suppliers, wholesalers, companies, manufacturers, exporters, ... iron dextran injection. You May Also Be Interested In: dextran iron dextran iron dextran injection iron injection piglet ... It is a colloidal solution of complex of dextran and iron possessed deep brown color. Each ml solution contains: iron dextran ...
Molecular weightInjectionSide effects of iron dextranPolysaccharideAdministration of dextranOral Dextran SulfateRelated to iron-dextranPolymerReceive iron dextranGlobal Dextran marketDextravenNanoparticlesMoleculeGlucoseSucroseIronEffect of dextranStructure of dextranProduction of dextranLeuconostocSulfate sodium saltMiceFITC-DextranFluorescently-labelledAnionicConjugatesFluorescent10,000VivoInflammationBacteriaInulin40,000AssayLinkagesSize-exclusion chroDEAETracersSulphateHydrogelsDoseConcentrationIncreasesWater-solubleApplying osmoticPolysaccharidesExperimental ColitisOphthalmicMurine colitisTreat hypovolemiaOverdose
- Dextran is a high molecular weight glucose polymer produced by the action of the bacteria, Leuconostoc mesenteroides , on a sucrose substrate. (ewg.org)
- Low-molecular-weight dextran in acute myocardial infarction. (bmj.com)
- Borchgrevink C. F. , Enger E. . Low-molecular-weight dextran in acute myocardial infarction. (bmj.com)
- IRON HYDROGENATED DEXTRAN INJECTION is a sterile solution containing 100 mg of elemental iron per mL, stabilized with a low molecular weight hydrogenated dextran and 0.5% phenol as a preservative. (nih.gov)
- Dextran 40 is a sterile, nonpyrogenic preparation of low molecular weight dextran (average mol. (drugbank.ca)
- Dextran 75 is a complex branched glucan with an average molecular weight 75000 Daltons. (drugbank.ca)
- 6,7 Native dextran has been found to have a molecular weight (MW) in the range of 9 million to 500 million. (sigmaaldrich.com)
- Dr. Bailie reported that during the 6-year observation period, annual sales increased in Europe for ferric gluconate (1.4 to 1.6 million DEq), iron sucrose (0.65 to 1.9 million DEq), and iron dextran, which has only been in a low-molecular-weight formulation since 2005 (0.02 to 0.15 million DEq). (medscape.com)
- Only low-molecular-weight (LMW) iron dextran has been sold in Europe since 2005. (medscape.com)
- In addition, the difference in AE rates for iron dextran might reflect the higher use of high-molecular-weight iron dextran in North America. (medscape.com)
- What is the most important information I should know about high-molecular weight dextran? (cardiosmart.org)
- High-molecular weight dextran is a plasma volume expander derived from natural sources of sugar (glucose). (cardiosmart.org)
- What should I discuss with my health care provider before I receive high-molecular weight dextran? (cardiosmart.org)
- What should I avoid after receiving high-molecular weight dextran? (cardiosmart.org)
- It is not known whether high-molecular weight dextran passes into breast milk or if it could harm a nursing baby. (adventisthealthcare.com)
- Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are receiving high-molecular weight dextran. (adventisthealthcare.com)
- What are the possible side effects of high-molecular weight dextran? (adventisthealthcare.com)
- What other drugs will affect high-molecular weight dextran? (adventisthealthcare.com)
- Other drugs may interact with high-molecular weight dextran, including prescription and over-the-counter medicines, vitamins, and herbal products. (adventisthealthcare.com)
- We offer more than 50 fluorescent and biotinylated dextran conjugates in several molecular weight ranges. (thermofisher.com)
- Dextrans are hydrophilic polysaccharides characterized by their moderate-to-high molecular weight, good water solubility, and low toxicity. (thermofisher.com)
- Furthermore, we use rigorous methods for removing as much unconjugated dye as practical, and then assay our dextran conjugates by thin-layer chromatography to help ensure the absence of low molecular weight contaminants. (thermofisher.com)
- Bamba S, Andoh A, Ban H, et al: The severity of dextran sodium sulfate-induced colitis can differ between dextran sodium sulfate preparations of the same molecular weight range. (mpbio.com)
- Researchers noted that the key points for production of dextran in industry are its molecular weight and dextran yield and, keeping these points in view, L. mesenteroides AA1 is a potential candidate for dextran production on an industrial scale. (foodprocessing-technology.com)
- Dextran is a high molecular weight polymer of glucose which is a complex branched glucan (polysaccharide made of many glucose molecules) composed of chains of varying lengths (from 3 to 2000 kilo Daltons). (reportsnreports.com)
- Spinal anesthesia was induced in 75 surgical patients, using one of three different fluid regimens: intravenous 'bolus injection' of 5 ml kg(-1) of Ringer's acetate over 3 min, 2 ml kg(-1) of low-molecular weight (1 kDa) dextran over 3 min, or a constant-rate infusion of 15 ml kg(-1) of Ringer's acetate over 40 min (controls). (diva-portal.org)
- The role of structure and molecular weight in fermentation selectivity in linear α-1,6 dextrans and dextrans with α-1,2 branching was investigated. (asm.org)
- Dextran is a polysaccharide consisting of a polymer of glucose molecules with a molecular weight between 75,000-100,000. (radiopaedia.org)
- Low molecular weight dextran sulfate (DXS) has been reported to inhibit the classical, alternative pathway as well as the mannan-binding lectin pathway of the complement system. (jimmunol.org)
- Low molecular weight dextran sulfate (DXS), 3 a sulfated polysaccharide of m.w. 5000, is known to inhibit alternative, classical, and lectin complement pathways ( 1 ) as well as the coagulation cascade ( 2 ). (jimmunol.org)
- Iron dextran injection may cause severe or life-threatening reactions while you receive the medication. (medlineplus.gov)
- You will receive this medication in a medical facility and your doctor will watch you carefully during each dose of iron dextran injection. (medlineplus.gov)
- Before you receive your first dose of iron dextran injection, your doctor will give you a test dose of medication and watch you carefully for at least 1 hour for any signs of an allergic reaction. (medlineplus.gov)
- You may be at a higher risk of having an allergic reaction to iron dextran injection. (medlineplus.gov)
- You should only receive iron dextran injection if you have a condition that cannot be treated with iron supplements that are taken by mouth. (medlineplus.gov)
- Iron dextran injection is used to treat iron-deficiency anemia (a lower than normal number of red blood cells due to too little iron) in people who cannot be treated with iron supplements taken by mouth. (medlineplus.gov)
- Iron dextran injection is in a class of medications called iron replacement products. (medlineplus.gov)
- Iron dextran injection comes as a solution (liquid) to inject into the muscles of the buttocks or intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
- Your doctor will determine how often you receive iron dextran injection and your total number of doses based on your weight, medical condition, and how well you respond to the medication. (medlineplus.gov)
- You may experience a delayed reaction to iron dextran injection, beginning 24 to 48 hours after receiving a dose of medication and lasting for approximately 3 to 4 days. (medlineplus.gov)
- or any of the ingredients in iron dextran injection. (medlineplus.gov)
- If you become pregnant while receiving iron dextran injection, call your doctor. (medlineplus.gov)
- If you miss an appointment to receive iron dextran injection, call your doctor as soon as possible. (medlineplus.gov)
- Iron-dextran complex has been tested in mice, rabbits and rats by repeated subcutaneous or intramuscular injections, producing local tumours at the injection site [ref: 1,5]. (inchem.org)
- The Working Group noted that iron-dextran complex accumulates at the site of injection in rodents, in contrast to its rapid dispersal after injection in human beings. (inchem.org)
- Dextran is given as an injection through a needle placed into a vein. (cardiosmart.org)
- Iron Dextran , manufactured by Guangxi Research Institute of Chemical Industry, is a quickacting veterinary medicine which is a new type iron - dextran injection applied in domestic animals. (flemtam.com)
Side effects of iron dextran3
- Dextran is a complex branched glucan (polysaccharide derived from the condensation of glucose), originally derived from wine. (wikipedia.org)
- Dextran is a polysaccharide that differs from others in that its glucose units are joined together 1:6 glucoside links. (drugbank.ca)
- Dextran is a polysaccharide consisting of glucose monomers linked mainly by α(1-6) bonds, produced by numerous microorganisms. (ovid.com)
- Phenoxodiol, an isoflavene anti-tumor agent, was conjugated on the polysaccharide dextran using immobilized laccase as biocatalyst. (frontiersin.org)
- This study provides further evidence that the conjugation of natural product-derived drugs onto polysaccharide molecules such as dextran can lead to better stability and enhanced biological activity of the conjugate compared to the free drug alone. (frontiersin.org)
Administration of dextran3
- Still, no difference has been detected in antithrombotic effectiveness in comparison of intra-arterial and intravenous administration of dextran. (wikipedia.org)
- Thereby, dextran 1 binds up antibodies towards dextran without causing the immune response, leaving less antibodies left to bind to the entire dextran complex, causing less risk of an immune response upon subsequent administration of dextran. (wikipedia.org)
- Several animal models have been used to study colitis and one such method involves the oral administration of dextran sulfate sodium (DSS) in the drinking water of mice, leading to chronic colitis. (mpbio.com)
Oral Dextran Sulfate5
- To evaluate the tolerance and safety of oral dextran sulfate (UAOO1), a potent in-vitro inhibitor of human immunodeficiency virus (HIV) in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. (annals.org)
- Oral dextran sulfate was given three times daily in total daily doses of 900 to 5400 mg for 8 weeks. (annals.org)
- Oral dextran sulfate was given without significant side effects. (annals.org)
- Oral dextran sulfate appears to be well tolerated. (annals.org)
- However, in view of the promising invitro effects and acceptable toxicity, oral dextran sulfate as a potential antiretroviral agent continues to be studied. (annals.org)
Related to iron-dextran1
- Only one, a poorly differentiated spindle-cell fibrosarcoma, was believed likely to be related to iron-dextran injections given 14 years previously [ref: 4]. (inchem.org)
- This characteristic branching distinguishes a dextran from a dextrin, which is a straight chain glucose polymer tethered by α-1,4 or α-1,6 linkages. (wikipedia.org)
- Dextran is a polymer of anhydroglucose. (sigmaaldrich.com)
- Diethylaminoethyl (DEAE)-dextran is a polycationic derivative of the carbohydrate polymer dextran, and it is one of the first chemical reagents used to transfer nucleic acids into cultured mammalian cells (Vaheri and Pagano, 1965). (thermofisher.com)
- Nucleic acid-DEAE-dextran complexes are formed via electrostatic interactions between the polymer and phosphate backbone of the nucleic acid. (thermofisher.com)
- Eventually, she found a way to mass produce dextran, a type of polymer, so that it could be used as a blood volume "expander" to sustain accident and trauma victims who have lost massive amounts of blood and need to get to a hospital for a transfusion. (federallabs.org)
Receive iron dextran1
- You should not receive iron dextran if you have a type of anemia that is not caused by iron deficiency. (cigna.com)
Global Dextran market2
- The global Dextran market will reach Volume Million USD in 2017 with CAGR xx% 2018-2025. (reportsnreports.com)
- Secondly, the report states the global Dextran market size (volume and value), and the segment markets by regions, types, applications and companies are also discussed. (reportsnreports.com)
- Pharma Grade Active Pharmaceutical Powder Dextran For Anticoagulant CAS 9004-54-0 Product Name Dextran Alias dextrans ;Dextraven CAS NO 9004-54-0 EINECS 232-677-5 Purity 99% Appearance white crystals or powder Certification ISO 9001, USP. (flemtam.com)
- Dextran can be used as a stabilizing coating to protect metal nanoparticles from oxidation and improve biocompatibility. (wikipedia.org)
- We previously demonstrated the suitability of novel dextran-coated superparamagnetic iron oxide nanoparticles (SPION Dex ) for biomedical applications in terms of safety and biocompatibility. (dovepress.com)
- Choi, K. C. Self-organized nanoparticles based on chitosan-folic acid and dextran succinate-doxorubicin conjugates for drug targeting. (alfa.com)
- Liu, J. and Liu, X. (2011), Nanoparticles prepared by blending of carboxylic acid terminated poly(ε-caprolactone) and L -phenylalanine substituted dextran. (wiley.com)
- In the current work, a sustained drug delivery system of flutamide (FLT) was developed using chitosan (CS) and dextran sulphate (DS) nanoparticles and were characterized using different techniques. (amrita.edu)
- Rose Bengal attached and dextran coated gadolinium oxide nanoparticles for potential diagnostic imaging applications. (americanelements.com)
- We report here, reverse micelle mediated synthesis of multifunctional dextran (dex) coated GdO nanoparticles (NPs) carrying rose bengal (RB) dye for magnetic resonance and optical imaging. (americanelements.com)
- Dextran coupled with a fluorescent molecule such as fluorescein isothiocyanate can be used to create concentration gradients of diffusible molecules for imaging and allow subsequent characterization of gradient slope. (wikipedia.org)
- The cationic DEAE‑dextran molecule tightly associates with the negatively charged backbone of the nucleic acid, and the net positive charge of the resulting nucleic acid-DEAE‑dextran complex allows it to adhere to the cell membrane and enter into the cytoplasm via endocytosis or osmotic shock induced by DMSO or glycerol. (thermofisher.com)
- We employ succinimidyl coupling of our dyes to the dextran molecule, which, in most cases, results in a neutral or anionic dextran. (thermofisher.com)
- Approximately 15 Gd-DTPA molecules are attached to each dextran molecule with an easily hydrolyzable bond. (radiopaedia.org)
- FITC is conjugated randomly to hydroxyl groups of dextran at a frequency of 0.003 to 0.02 moles of FITC per mole of glucose. (sigmaaldrich.com)
- Based on the spectral data, we found that the dextran contained only D-glucose residues. (nih.gov)
- Dextrans are biologically inert due to their uncommon poly-(α-D-1,6-glucose) linkages, which render them resistant to cleavage by most endogenous cellular glycosidases. (thermofisher.com)
- Dextran is a complicating contaminant in the refining of sugar because it elevates the viscosity of sucrose solutions and fouls plumbing. (wikipedia.org)
- Dextran is now produced from sucrose by certain lactic acid bacteria of the family lactobacillus. (wikipedia.org)
- [ 2 ] Many bacteria, like Leuconostoc , can synthesize dextran from sucrose, and this activity is used commercially to obtain dextran. (drugbank.ca)
- Sales increased in North America for iron sucrose (1.1 to 2.8 million DEq), were unchanged for ferric gluconate (1.0 to 0.97 million DEq), and decreased for iron dextran (0.33 to 0.26 million DEq). (medscape.com)
- Since household sucrose, fruits or fruit beverages could be contaminated with traces of dextrans, ingestion of dextrans, albeit in small amounts, may not be uncommon. (lookchem.com)
- In addition, the per cent conversion of sucrose to dextran by L. mesenteroides AA1 was found to be 48.9%, compared with strain L. mesenteroides B-512F which has 41% conversion, Foodnavigator.com reported. (foodprocessing-technology.com)
- These organisms were screened for their dextran producing property by selecting mucoid colonies on plate count agar (PCA), MRS agar and malt extract (ME) agar medium containing 10% sucrose. (ovid.com)
- What is the most important information I should know about iron dextran? (cigna.com)
- Iron dextran can cause severe and sometimes fatal allergic reactions or severely low blood pressure. (cigna.com)
- What is iron dextran? (cigna.com)
- Iron dextran is a form of the mineral iron. (cigna.com)
- Iron dextran is used to treat iron deficiencies and iron deficiency anemia (low red blood cells). (cigna.com)
- Iron dextran may also be used for purposes not listed in this medication guide. (cigna.com)
- What should I discuss with my healthcare provider before receiving iron dextran? (cigna.com)
- FDA pregnancy category C. It is not known whether iron dextran will harm an unborn baby. (cigna.com)
- Iron dextran can pass into breast milk and may harm a nursing baby. (cigna.com)
- How is iron dextran given? (cigna.com)
- Iron dextran is injected into a vein through an IV. (cigna.com)
- Iron dextran must be given slowly. (cigna.com)
- Do not mix iron dextran with other medicines or liquid (diluent) in the same syringe or IV container. (cigna.com)
- Do not use iron dextran if it has changed colors or has particles in it. (cigna.com)
- Iron dextran doses are based on these measures. (cigna.com)
- You may not notice any change in your symptoms, but your blood work will help your doctor determine how long to treat you with iron dextran. (cigna.com)
- Tell any doctor who treats you that you are using iron dextran. (cigna.com)
- Call your doctor for instructions if you miss a dose of iron dextran. (cigna.com)
- What should I avoid while using iron dextran? (cigna.com)
- and in certain intravenous fluids to solubilize other factors, such as iron (in a solution known as Iron Dextran). (wikipedia.org)
- Along with its needed effects, iron dextran may cause some unwanted effects. (drugs.com)
- In Europe and North America, the rates of total AEs, anaphylaxis, and anaphylactoid reactions were several-fold higher with IV iron dextran than with other IV iron products. (medscape.com)
- For North America, the figure represents the total sales of all forms of iron dextran. (medscape.com)
- Iron dextran is an iron replacement product that is used to treat iron deficiency, such as anemia (not enough iron in the blood) or blood loss in patients with certain conditions (eg, hemophilia, gastrointestinal bleeding). (mayoclinic.org)
- An early report was made of a woman who had developed an undifferentiated soft-tissue sarcoma following multiple injections of iron-dextran complex [ref: 1]. (inchem.org)
- It seems probable that the considerable publicity given to the initial case report [ref: 1] and the tendency to give parenteral iron therapy intravenously may have considerably reduced human exposure to intramuscularly administered iron-dextran complex. (inchem.org)
- Iron dextran complex is possibly carcinogenic to humans (Group 2B) . (inchem.org)
- It is a colloidal solution of complex of dextran and iron possessed deep brown color. (fuzing.com)
- Each ml solution contains: iron dextran equivalent to 100 mg iron. (fuzing.com)
- What is Iron Dextran (Infed) used for? (everydayhealth.com)
- Iron dextran can cause injury to the unborn baby if you take the medicine during your second or third trimester. (everydayhealth.com)
- Can I take Iron Dextran (Infed) if I'm pregnant or breastfeeding? (everydayhealth.com)
- Use Iron Dextran (Infed) exactly as directed on the label, or as prescribed by your doctor. (everydayhealth.com)
- Iron dextran is given as an infusion into a vein. (everydayhealth.com)
- Changes in cortisol concentrations and leukocyte counts were influenced by handling stress and were not specifically correlated to iron dextran application. (mdpi.com)
- Iron concentrations in the internal environment of the experimental piglets' group were higher by an order of magnitude compared with the controls, and the highest serum concentrations of iron (p 3+ -dextran administration. (mdpi.com)
- Cyclobenzaprine influenced because iron dextran began going from the business? (newqite.com)
- Methods we did a randomised clinical drug trial to test equivalence of dipotassium phosphate donor and iron dextran for master the treatment of monoarticular gout. (newqite.com)
- Effect of intravenous iron dextran on rheumatoid synovitis. (bmj.com)
- All iron dextran powder wholesalers & iron dextran powder manufacturers come from members. (flemtam.com)
- We doesn't provide iron dextran powder products or service, please contact them directly and verify their companies info carefully. (flemtam.com)
- IRON DEXTRAN 38% CAS NO.:9004-66-4 HEAVY METAL:≤ 20ppm (Ferric Content)：≥38％ （Quality Standard）: ①USP28 ；②USP34 Rational Formula：(C6H10O5)m「Fe(OH)3」× Iron Dextran （Description）： （It. (flemtam.com)
- for iron Iron dextran solution 5%47.5-52.5mgFe/ml Iron dextran solution 10%95.0-105.0mgFe/ml Iron dextran solution 15%142.5-157.5mgFe/ml Iron dextran solution 20%190.0-210.0mgFe/ml Iron dextran powder 25%>25.0% Iron dextran powder 30% 28%-32% Iron dextran . (flemtam.com)
- Iron dextran is used for the treatment of iron-deficiency anaemia where oral therapy is ineffective or impracticable. (mims.com)
- Disclaimer: This information is independently developed by MIMS based on Iron dextran from various references and is provided for your reference only. (mims.com)
- The primary objective of this study is to assess the safety of an investigational intravenous iron (ferric carboxymaltose [FCM]) or an equal dose of iron dextran and explore the mechanism of hypophosphatemia following administration of FCM or that of an equal dose of iron dextran when treating women with iron deficiency anemia due to heavy uterine bleeding (HUB). (clinicaltrials.gov)
- Drug information on IMFERON F-12 inj® (Iron Dextran) from Shreya Life Sciences Pvt. (medindia.net)
- Iron Dextran(Infed) generic IMFERON F-12 inj® is an essential mineral, prescribed for anemia or iron deficiency, megaloblastic anemia as an astringent. (medindia.net)
Effect of dextran1
- The antithrombotic effect of dextran is mediated through its binding of erythrocytes, platelets, and vascular endothelium, increasing their electronegativity and thus reducing erythrocyte aggregation and platelet adhesiveness. (wikipedia.org)
Structure of dextran1
- The structure of dextran produced depends not only on the family and species of the bacterium but on the strain. (wikipedia.org)
Production of dextran3
- Production of dextran in transgenic potato plants. (sigmaaldrich.com)
- The production of dextran in potato tubers and its effect on starch biosynthesis were investigated. (sigmaaldrich.com)
- Currently, the bacterial strain L. mesenteroides B-512F is used for the production of dextran, as it is capable of producing water-soluble and insoluble dextran with diversified properties. (foodprocessing-technology.com)
Sulfate sodium salt1
- Dextran sulfate sodium salt, or DSS, is a branched glucan that triggers colitis in mice and rats when administered in drinking water. (mpbio.com)
- M. Song, D. K. Park, and H. J. Park, "Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages," Journal of Ethnopharmacology , vol. 154, no. 2, pp. 311-318, 2014. (hindawi.com)
- We first developed a procedure to treat burn wounds on mice with dextran hydrogels. (pnas.org)
- The effect of ethanol extract derived from B. nivea (EBN) on colon length, body weight, and disease activity index (DAI) in dextran sulfate sodium- (DSS-) induced colitis mice. (hindawi.com)
- To investigate the effect of magnolol in dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated with 2% DSS drinking water for 5 consecutive days followed by intragastric administration with magnolol (5, 10 and 15 mg/kg) daily for 7 days. (mdpi.com)
- Bian, Z.-X. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. (mdpi.com)
- This study aimed to investigate the effects of two selenium-containing amino acids - selenocysteine and selenocystine - on oxidative stress and chronic inflammation in a mouse model of dextran sulfate sodium (DSS)-induced IBD.Methodology: C57BL/6 mice were randomly assigned to the following six groups: control, DSS, DSS+selenocysteine, DSS+selenocystine, DSS+sodium selenite, and DSS+N-acetylcysteine (NAC). (doaj.org)
- Herein, we investigated the protective efficacy and potential mechanism of phloretin in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. (rsc.org)
- To develop an efficient animal model for colitis-related carcinogenesis, male Crj: CD-1 (ICR) mice were given a single intraperitoneal administration (10 mg/kg body weight) of a genotoxic colonic carcinogen, azoxymethane (AOM), and a 1-week oral exposure (2% in drinking water) to a non-genotoxic carcinogen, dextran sodium sulfate (DSS), under various protocols. (nih.gov)
- Optical imaging of mice (n = 4) using the targeted probe, Cy5.5-DTPA-galactosyl-dextran (2.2 Cy5.5, 4 DTPA, 68 galactose units per dextran, 124 kDa, 24 nmol/kg), demonstrated blood clearance and hepatic uptake. (nih.gov)
- Fam96a deficiency in mice resulted in increased susceptibility to dextran sulfate sodium (DSS)-induced colitis. (frontiersin.org)
- The present study investigated the effect and mechanism of DHEA in dextran sulfate sodium (DSS)-induced colitis mice. (unboundmedicine.com)
- TY - JOUR T1 - Effect of dehydroepiandrosterone on the immune response and gut microbiota in dextran sulfate sodium-induced colitis mice. (unboundmedicine.com)
- In the present study, we examined the effects of auraptene on MMP-2, -7, and -9 expression in colonic mucosa from dextran sulfate sodium (DSS)-induced ulcerative colitis mice. (nii.ac.jp)
- The excitation maximum of FITC-dextran is 490 nm. (sigmaaldrich.com)
- Stored properly at 2-8°C and protected from light FITC-dextran powders should be stable for a minimum of two to three years. (sigmaaldrich.com)
- In vivo, FITC-dextran is stable for more than 24 hours. (sigmaaldrich.com)
- FITC-dextran is used extensively in microcirculation and cell permeability research utilizing microfluorimetry. (sigmaaldrich.com)
- 22,23 FITC-dextran has been used to study plant cell wall porosity 24 and capillary permeability. (sigmaaldrich.com)
- 25,26 Plasma proteins have been shown not to bind to FITC-dextran. (sigmaaldrich.com)
- This method utilizes FITC-dextran, which accumulates in lysosome-related organelles, as a reporter. (jove.com)
- Solutions of fluorescently-labelled dextran can be perfused through engineered vessels to analyze vascular permeability Dextran is used to make microcarriers for industrial cell culture Orally-administered dextran sodium sulphate is used to induce colitis in animal models of inflammatory bowel disease. (wikipedia.org)
- The reaction used to produce the Rhodamine Green™ and Alexa Fluor ® 488 dextrans results in the final product being neutral, anionic, or cationic. (thermofisher.com)
- The Alexa Fluor ® , Cascade Blue ® , lucifer yellow, fluorescein, and Oregon Green ® dextrans are intrinsically anionic, whereas most of the dextrans labeled with the zwitterionic rhodamine B, tetramethylrhodamine, and Texas Red ® dyes are essentially neutral. (thermofisher.com)
- fluorescent-labelled dextran can be used to visualize these endosomes under a microscope. (wikipedia.org)
- In most cases, Molecular Probes® fluorescent dextrans are much brighter and have higher negative charge than dextrans available from other sources. (thermofisher.com)
- CF® dye labeled dextrans could be used as a fluorescent fluid-phase markers to study cell permeability, endocytosis, or mechanisms of biomolecular delivery. (biotium.com)
- The results showed a slightly but statistically significantly deeper follicular penetration of fluorescent signals corresponding to TRITC-dextran as opposed to fluorescence corresponding to the FITC-labeled particles. (diva-portal.org)
- Oral in vivo Bactofection in Dextran Sulfate Sodium Treated Femal. (ingentaconnect.com)
- In the present study therefore, we investigated whether glucosamine exhibits the anti-inflammatory effect in vivo, using dextran sulfate sodium (DSS)-induced colitis in rats, a model of inflammatory bowel diseases (IBD). (spandidos-publications.com)
- However, dextran sodium sulfate induced inflammation could not be confirmed by plasma levels of Il1, Il6 and TNFalpha. (ingentaconnect.com)
- Although some parameters showed a tendency to improve, the inflammation caused by administration of 4% dextran sodium sulfate during 7 days was low and contradictory to other studies. (ingentaconnect.com)
- Dextran was discovered by Louis Pasteur as a microbial product in wine, but mass production was only possible after the development by Allene Jeanes of a process using bacteria. (wikipedia.org)
- Some bacteria coproduce fructans, which can complicate isolation of the dextrans. (wikipedia.org)
- The root beer turned out to have been contaminated with a type of bacteria that produced dextran. (federallabs.org)
- Other measured bacteria were unaffected by the test substrates except for the Bacteroides-Prevotella group, the growth levels of which were increased on inulin and 6- and 70-kDa dextrans, and the Faecalibacterium prausnitzii group, the growth levels of which were decreased on inulin and 1-kDa dextrans. (asm.org)
- A considerable increase in short-chain fatty acid concentration was measured following the fermentation of all dextrans and inulin. (asm.org)
- Gas production rates were similar among all dextrans tested but were significantly slower than that for inulin. (asm.org)
- The linear 1-kDa dextran produced lower total gas and shorter time to attain maximal gas production compared to those of the 70-kDa dextran (branched) and inulin. (asm.org)
- The aim of this study was to investigate the physical and immunogenic stability of spray freeze-dried whole inactivated virus influenza vaccine prepared by using inulin, dextran, and a mixture of dextran and trehalose as protectants. (unboundmedicine.com)
- In this family, dextran-40 (MW: 40,000 Da), has been the most popular member for anticoagulation therapy. (wikipedia.org)
- The remaining (163) linkages account for the branching of dextran. (sigmaaldrich.com)
- 14 The MW of dextran is measured by one or more of the following methods: low angle laser light scattering, 15 size exclusion chromatography, 16 copper-complexation 17 and anthrone reagent 18 colorometric reducing-end sugar determination and viscosity. (sigmaaldrich.com)
- Fractionation can be accomplished by size exclusion chromatography 16 or ethanol fractionation, where the largest MW dextrans precipitate first. (sigmaaldrich.com)
- The dextran was purified by size exclusion chromatography, and the structure was determined by Fourier transform infrared spectroscopy, nuclear magnetic resonance, and gas chromatography-mass spectrometer. (nih.gov)
- The advantages of DEAE-dextran method are its relative simplicity, reproducibility, and low cost, while its disadvantages include cytotoxicity and low transfection efficiency for a range of cell types (typically less than 10% in primary cells), as well as the requirement for reduced serum media during the transfection procedure. (thermofisher.com)
- Mix nucleic acid with DEAE-dextran solution in transfection medium or phosphate-buffered saline solution. (thermofisher.com)
- Add the nucleic acid-DEAE-dextran complexes to the cells, which adhere to the cell surface via electrostactic interactions. (thermofisher.com)
- Induce the uptake of the nucleic acid-DEAE-dextran complexes by osmotic shock using DMSO or glycerol. (thermofisher.com)
- DEAE-dextran-mediated transfection workflow. (thermofisher.com)
- These dextrans have covalently bound lysine residues that permit dextran tracers to be conjugated to surrounding biomolecules by aldehyde-mediated fixation for subsequent detection by immunohistochemical and ultrastructural techniques. (thermofisher.com)
- Dextran sulphate induced arthritis in rabbits. (bmj.com)
- Lars, H. and Helle, B. (1995) Dextran Hydrogels for Colon-Specific Drug Delivery. (scirp.org)
- We hypothesize that dextran-based hydrogels can serve as instructive scaffolds to promote neovascularization and skin regeneration in third-degree burn wounds. (pnas.org)
- Dextran hydrogels are soft and pliable, offering opportunities to improve the management of burn wound treatment. (pnas.org)
- Since dextran is given as needed by a healthcare professional, it is not likely that you will miss a dose. (cardiosmart.org)
- A single dose of Fe 3+ -dextran produced a special stress situation in the piglets' organism which manifested itself by an increased production of neopterin (p (mdpi.com)
- The dose of dextran Gd-DTPA in these studies was 0.01-0.05 mmol/kg 1 . (radiopaedia.org)
- The concentration of dextran was ranged to 100 g/L. In the increasing concentration of dextran, the activity of papain decreased due to the low diffusivity of papain and substrate. (scirp.org)
- The dextran concentration appeared two times higher in the Kardal (about 1.7 mg/g FW) than in the amf transformants. (sigmaaldrich.com)
- Among these K. pneumoniae P100 produced the maximum concentration of dextran (6,800 ppm) at stationary phase within 12 h of incubation in CM. Biocide, Dimethyl Benzyl Ammonium Chloride (DBAC) (2 ppm) commonly used to inhibit some microorganisms in the modern cane milling process at Mitr Phuveing Sugar Factory, could not inhibit K. pneumoniae P100 within 30 minutes. (ovid.com)
- The release of TRITC-dextran from the particles was induced by washing of the nanocarriers, which were kept in a buffer containing TRITC-labeled dextran to balance out the diffusion of the dextran during storage, thereby changing the concentration gradient. (diva-portal.org)
- A novel water-soluble dextran was synthesized from maltodextrin by cell-free extract of Gluconobacter oxydans DSM 2003. (nih.gov)
- citation needed] Dextran can be used in an ATPS for PEGylation Dextran is used in the osmotic stress technique for applying osmotic pressure to biological molecules. (wikipedia.org)
- Labeled dextrans are hydrophilic polysaccharides most commonly used in microscopy studies to monitor cell division, track the movement of live cells, and to report the hydrodynamic properties of the cytoplasmic matrix. (thermofisher.com)
- Of the chemical induced colitis models, dextran sodium sulfate (DSS) induced colitis model is a relatively simple and very widely used model of experimental colitis. (bio-protocol.org)
- Dextran as well presents ophthalmic applications as solutions or ointments for the temporary relief of xerophthalmia or minor ocular irritations. (drugbank.ca)
- Clinicopathologic study of dextran sulfate sodium experimental murine colitis. (nih.gov)
- We undertook this study in order to fully characterize the clinical and histopathology features of the dextran sulfate sodium (DSS) model of experimental murine colitis and to discover the earliest histopathologic changes that lead to colitis. (nih.gov)
- Outside of these features, larger dextrans, which do not pass out of the vessels, are potent osmotic agents, thus have been used urgently to treat hypovolemia. (wikipedia.org)
- Dextran is used to treat hypovolemia (a decrease in the volume of circulating blood plasma), that can result from severe blood loss after surgery, injury, or other causes of bleeding. (cardiosmart.org)
- An overdose of dextran is not expected to produce life-threatening symptoms. (cardiosmart.org)