An anti-inflammatory 9-fluoro-glucocorticoid.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Substances that reduce or suppress INFLAMMATION.
Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.
Drugs used to prevent NAUSEA or VOMITING.
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
The forcible expulsion of the contents of the STOMACH through the MOUTH.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Excision of one or both adrenal glands. (From Dorland, 28th ed)
A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
The relationship between the dose of an administered drug and the response of the organism to the drug.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Inorganic or organic compounds that contain the basic structure RB(OH)2.
A dopamine D2 antagonist that is used as an antiemetic.
Therapy with two or more separate preparations given for a combined effect.
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
Protein of the annexin family exhibiting lipid interaction and steroid-inducibility.
Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
Elements of limited time intervals, contributing to particular results or situations.
Emesis and queasiness occurring after anesthesia.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
Established cell cultures that have the potential to propagate indefinitely.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.
An enzyme that catalyzes the conversion of L-TYROSINE and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-GLUTAMATE. It is a pyridoxal-phosphate protein. L-PHENYLALANINE is hydroxylated to L-tyrosine. The mitochondrial enzyme may be identical with ASPARTATE AMINOTRANSFERASES (EC 2.6.1.1.). Deficiency of this enzyme may cause type II Tyrosinemia (see TYROSINEMIAS). EC 2.6.1.5.
Inflammation involving the GLOTTIS or VOCAL CORDS and the subglottic larynx. Croup is characterized by a barking cough, HOARSENESS, and persistent inspiratory STRIDOR (a high-pitched breathing sound). It occurs chiefly in infants and children.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The rate dynamics in chemical or physical systems.
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Specific receptors for glucocorticoid in the cytoplasm of the liver of AH 130 tumor-bearing rats. (1/8350)

Specific receptors for dexamethasone (11beta, 17alpha, 21-trihydroxy-9alpha-fluoro-16alpha-methyl-1,4-pregnadiene-3,20-dione) in the cytoplasm of the liver from AH 130 (solid type) tumor-bearing rats markedly increased in the advanced stage of tumor growth. The cytoplasmic receptors of the livers of normal and tumor-bearing rats differed in their affinities for dexamethasone, and their apparent equilibrium (dissociation) constants (K) for dexamethasone were 4.0 and 2.6 X 10(-9) M, respectively. The rates of dissociation of dexamethasone-receptor complexes and the heat denaturations of the receptors in the livers of normal and tumor-bearing rats were similar. The glucocorticoid receptors of tumor-bearing rat liver had slightly higher affinities than did those of normal liver for all the steroids tested. Only a trace amount of receptors for dexamethasone could be detected in the cytoplasm of AH 130 ascites cells.  (+info)

The effects of glucocorticoids and progesterone on hormone-responsive human breast cancer in long-term tissue culture. (2/8350)

Glucocorticoids, at physiological concentration, inhibit cell division and thymidine incorporation in three lines of human breast cancer maintained in long-term tissue culture. At steroid concentrations sufficient to inhibit thymidine incorporation 50%, little or no effect is seen on protein synthesis 48 hr after hormone addition. All three of these lines are shown to have glucocorticoid receptors demonstrable by competitive protein binding assays. Receptors are extensively characterized in one line by sucrose density gradient analysis and binding specificity studies. Good correlation between receptor-binding specificity and biological activity is found except for progesterone, which binds to glucocorticoid receptor but is noninhibitory. Cross-competition and quantification studies demonstrate a separate receptor for progesterone. This receptor has limited binding specificities restricted largely to progestational agents, whereas the glucocorticoid receptor bound both glucocorticoids and progesterone. Two other human breast cancer lines neither contain glucocorticoid receptor nor are inhibited by glucocorticoids. It is concluded that in some cases glucocorticoids can directly limit growth in human breast cancer in vitro without requiring alterations in other trophic hormones.  (+info)

Effect of hepatocarcinogens on the binding of glucocorticoid-receptor complex in rat liver nuclei. (3/8350)

The effects of a number of carcinogens and hepatotoxins on the binding kinetics of the interactions of glucocorticoidcytosol receptor complex with nuclear acceptor sites in rat liver were investigated. Both the apparent sites in rat liver were investigated. Both the apparent concentration of nuclear binding sites and the Kd were significantly diminished following treatment of rats with sublethal doses of the carcinogens aflatoxin B1, diethylnitrosamine, dimethylnitrosamine, thioacetamide, 3'-methyl-4-dimethylaminoazobenzene, 4-dimethylaminoazobenzene, and 3-methylcholanthrene. Treatment with actinomycin D resulted in a slight reduction in the apparent concentration of nuclear acceptor sites but had no effect on the nuclear binding Kd. The hepatotoxic but noncarcinogenic analgesic, acetaminophen, as well as the weakly toxic aflatoxin B1 cognate, aflatoxin B2, were without effect on the kinetics or binding capacity of glucocorticoid-nuclear acceptor site interaction. These experiments suggest that chemically induced alteration of functional glucocorticoid binding sites on chromatin may be involved in the biochemical effects produced in liver by carcinogens of several chemical types. This experimental model may provide a useful approach for further elucidation of early events in carcinogenesis.  (+info)

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. (4/8350)

BACKGROUND: The Jun N-terminal kinase (JNK) signaling pathway has been implicated in cell proliferation and apoptosis, but its function seems to depend on the cell type and inducing signal. In T cells, JNK has been implicated in both antigen-induced activation and apoptosis. RESULTS: We generated mice lacking the JNK2 isozymes. The mutant mice were healthy and fertile but defective in peripheral T-cell activation induced by antibody to the CD3 component of the T-cell receptor (TCR) complex - proliferation and production of interleukin-2 (IL-2), IL-4 and interferon-gamma (IFN-gamma) were reduced. The proliferation defect was restored by exogenous IL-2. B-cell activation was normal in the absence of JNK2. Activation-induced peripheral T-cell apoptosis was comparable between mutant and wild-type mice, but immature (CD4(+) CD8(+)) thymocytes lacking JNK2 were resistant to apoptosis induced by administration of anti-CD3 antibody in vivo. The lack of JNK2 also resulted in partial resistance of thymocytes to anti-CD3 antibody in vitro, but had little or no effect on apoptosis induced by anti-Fas antibody, dexamethasone or ultraviolet-C (UVC) radiation. CONCLUSIONS: JNK2 is essential for efficient activation of peripheral T cells but not B cells. Peripheral T-cell activation is probably required indirectly for induction of thymocyte apoptosis resulting from administration of anti-CD3 antibody in vivo. JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptosis induced by anti-Fas antibody, UVC or dexamethasone. JNK2 is not required for activation-induced cell death of mature T cells.  (+info)

Identification of a cAMP response element within the glucose- 6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells. (5/8350)

The expression of a luciferase reporter gene under the control of the human glucose 6-phosphatase gene promoter was stimulated by both dexamethasone and dibutyryl cAMP in H4IIE hepatoma cells. A cis-active element located between nucleotides -161 and -152 in the glucose 6-phosphatase gene promoter was identified and found to be necessary for both basal reporter-gene expression and induction of expression by both dibutyryl cAMP and dexamethasone. Nucleotides -161 to -152 were functionally replaced by the consensus sequence for a cAMP response element. An antibody against the cAMP response element-binding protein caused a supershift in gel-electrophoretic-mobility-shift assays using an oligonucleotide probe representing the glucose 6-phosphatase gene promoter from nucleotides -161 to -152. These results strongly indicate that in H4IIE cells the glucose 6-phosphatase gene-promoter sequence from -161 to -152 is a cAMP response element which is important for the regulation of transcription of the glucose 6-phosphatase gene by both cAMP and glucocorticoids.  (+info)

Production of prostaglandin f2alpha and its metabolite by endometrium and yolk sac placenta in late gestation in the tammar wallaby, Macropus Eugenii. (6/8350)

In this study, we investigated production of prostaglandin (PG) F2alpha and its metabolite, PGFM, by uterine tissues from tammar wallabies in late pregnancy. Endometrial explants were prepared from gravid and nongravid uteri of tammars between Day 18 of gestation (primitive streak) and Day 26.5 (term) and were incubated in Ham's F-10 medium supplemented with glutamine and antibiotics for 20 h. PGF2alpha and PGFM in the medium were assayed by specific, validated RIAs. Control tissues (leg muscle) did not produce detectable amounts of either PG. Both gravid and nongravid endometria secreted PGF2alpha, and production increased significantly in both gravid and nongravid uteri towards term. PGFM was produced in small amounts by both gravid and nongravid uteri, and the rate of production did not increase. Neither oxytocin nor dexamethasone stimulated PG production in vitro in any tissue at any stage. Thus, the surge in peripheral plasma PGFM levels seen at parturition may arise from increased uterine PG production, but further study is needed to define what triggers this release.  (+info)

Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells. (7/8350)

Glucocorticoid hormones, which are physiological regulators of mammary epithelium development, induce the formation of tight junctions in rat Con8 mammary epithelial tumor cells. We have discovered that, as part of this process, the synthetic glucocorticoid dexamethasone strongly and reversibly down-regulated the expression of fascin, an actin-bundling protein that also interacts with the adherens junction component beta-catenin. Ectopic constitutive expression of full-length mouse fascin containing a Myc epitope tag (Myc-fascin) in Con8 cells inhibited the dexamethasone stimulation of transepithelial electrical resistance, disrupted the induced localization of the tight junction protein occludin and the adherens junction protein beta-catenin to the cell periphery, and prevented the rearrangement of the actin cytoskeleton. Ectopic expression of either the carboxyl-terminal 213 amino acids of fascin, which includes the actin and beta-catenin-binding sites, or the amino-terminal 313 amino acids of fascin failed to disrupt the glucocorticoid induction of tight junction formation. Mammary tumor cells expressing the full-length Myc-fascin remained generally glucocorticoid responsive and displayed no changes in the levels or protein-protein interactions of junctional proteins or the amount of cytoskeletal associated actin filaments. However, a cell aggregation assay demonstrated that the expression of Myc-fascin abrogated the dexamethasone induction of cell-cell adhesion. Our results implicate the down-regulation of fascin as a key intermediate step that directly links glucocorticoid receptor signaling to the coordinate control of junctional complex formation and cell-cell interactions in mammary tumor epithelial cells.  (+info)

Role of dexamethasone dosage in combination with 5-HT3 antagonists for prophylaxis of acute chemotherapy-induced nausea and vomiting. (8/8350)

Dexamethasone (20 mg) or its equivalent in combination with 5-HT3 antagonists appears to be the gold-standard dose for antiemetic prophylaxis. Additional to concerns about the use of corticosteroids with respect to enhanced tumour growth or impaired killing of the tumour cells, there is evidence that high-dosage dexamethasone impairs the control of delayed nausea and emesis, whereas lower doses appear more beneficial. To come closer to the most adequate dose, we started a prospective, single-blind, randomized trial investigating additional dosage of 8 or 20 mg dexamethasone to tropisetron (Navoban), a 5-HT3 receptor antagonist, in cis-platinum-containing chemotherapy. After an interim analysis of 121 courses of chemotherapy in 69 patients, we have been unable to detect major differences between both treatment alternatives. High-dose dexamethasone (20 mg) had no advantage over medium-dose dexamethasone with respect to objective and subjective parameters of acute and delayed nausea and vomiting. In relation to concerns about the use of corticosteroids in non-haematological cancer chemotherapy, we suggest that 8 mg or its equivalent should be used in combination with 5-HT3 antagonists until further research proves otherwise.  (+info)

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Product Name: Ofloxacin and Dexamethasone Sodium Phosphate Eye and Ear Drops. Common Name: antibacterial prepration for eye and ear. Strength: 0.3% Ofloxacin + 0.1% Dexamethasone Sodium Phosphate. Description: Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.. Dexamethasone Sodium Phosphate, a synthetic adrenocortical steroid, is a white or slightly yellow crystalline powder. It is freely soluble in water and is exceedingly hygroscopic.. Indications and Usage:. Ofloxacin and Dexamethasone Sodium Phosphate Eye and Ear Drops is used to treat certain eye conditions due to inflammation or injury. Dexamethasone works by relieving symptoms such as swelling, redness, and itching. It belongs to a class of drugs known as corticosteroids.. This medication may also be used to treat swelling, redness, and itching of the outer ear due to inflammatory conditions.. Pack Size: Ofloxacin and Dexamethasone Sodium Phosphate Eye and Ear Drops ...
Dexamethasone Sodium Phosphate with NDC 67457-419 is a a human prescription drug product labeled by Mylan Institutional Llc. The generic name of Dexamethasone Sodium Phosphate is dexamethasone sodium phosphate.
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Background We compared adjunctive treatment with placebo, dexamethasone, anti-C5 antibodies, and the combination of dexamethasone plus anti-C5 antibodies in experimental pneumococcal meningitis. Methods In this prospective, investigator-blinded, randomized trial, 96 mice were infected intracisternally with 107 CFU/ml Streptococcus pneumoniae serotype 3, treated with intraperitoneal ceftriaxone at 20 h, and randomly assigned to intraperitoneal adjunctive treatment with placebo (saline), dexamethasone, anti-C5 antibodies, or dexamethasone plus anti-C5 antibodies. The primary outcome was survival during a 72-h observational period that was analyzed with the log-rank test. Secondary outcome was clinical severity, scored on a validated scale using a linear mixed model. Results Mortality rates were 16 of 16 mice (100 %) in the placebo group, 12 of 15 mice (80 %) in the dexamethasone group, 25 of 31 mice (80 %) in the anti-C5 antibody group, and 18 of 30 mice (60 %) in the dexamethasone plus anti-C5 ...
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Dexamethasone Sodium Phosphate Inj: Dexamethasone belongs to the group of medications known as corticosteroids. It may be used to treat a wide variety of conditions.
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Trade Name: Decadron, Dexasone, Diodex, Hexadrol, Maxidex. For which conditions is this drug approved? Dexamethasone is used in combination with other agents for the treatment of myeloma and lymphomas. Dexamethasone may also be used to help prevent or reduce nausea and vomiting, to reduce swelling and related pressure, or as an anti-inflammatory agent. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.. What is the mechanism of action? Dexamethasone is referred to as a glucocorticoid or corticosteroid. Dexamethasone may produce anti-cancer effects through several speculated mechanisms. One such mechanism may be the inhibition of inflammatory agents in the body, which have been implicated in the development or growth ...
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Serious Neurologic Adverse Reactions with Epidural Administration Serious neurologic events, some resulting in death, have been reported with epidural injection of corticosteroids. Specific events reported include, but are not limited to, spinal cord infarction, paraplegia, quadriplegia, cortical blindness, and stroke. These serious neurologic events have been reported with and without use of fluoroscopy. The safety and effectiveness of epidural administration of corticosteroids has not been established, and corticosteroids are not approved for this use. Because rare instances of anaphylactoid reactions have occurred in patients receiving parenteral corticosteroid therapy, appropriate precautionary measures should be taken prior to administration, especially when the patient has a history of allergy to any drug. Anaphylactoid and hypersensitivity reactions have been reported for dexamethasone sodium phosphate injection. (See ADVERSE REACTIONS).. Corticosteroids may exacerbate systemic fungal ...
Serious Neurologic Adverse Reactions with Epidural Administration Serious neurologic events, some resulting in death, have been reported with epidural injection of corticosteroids. Specific events reported include, but are not limited to, spinal cord infarction, paraplegia, quadriplegia, cortical blindness, and stroke. These serious neurologic events have been reported with and without use of fluoroscopy. The safety and effectiveness of epidural administration of corticosteroids has not been established, and corticosteroids are not approved for this use. Because rare instances of anaphylactoid reactions have occurred in patients receiving parenteral corticosteroid therapy, appropriate precautionary measures should be taken prior to administration, especially when the patient has a history of allergy to any drug. Anaphylactoid and hypersensitivity reactions have been reported for dexamethasone sodium phosphate injection. (See ADVERSE REACTIONS).. Corticosteroids may exacerbate systemic fungal ...
Dexamethasone Sodium Phosphate (Decadron, Dexasone, Diodex, Hexadrol, Maxidex) glucocorticosteroid, how its given, how it works, precautions and self care tips for treatment of side effects from chemotherapy treatment
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TY - JOUR. T1 - Extrahypothalamic CRH and its receptors change tyrosine hydroxylase expression after neonatal dexamethasone treatment. AU - Sukhareva, E. V.. AU - Lanshakov, D.. AU - Kalinina, T.. AU - Bulygina, V.. AU - Dygalo, N.. PY - 2019/12. Y1 - 2019/12. U2 - 10.1016/j.euroneuro.2019.09.438. DO - 10.1016/j.euroneuro.2019.09.438. M3 - Meeting Abstract. VL - 29. SP - S301-S302. JO - European Neuropsychopharmacology. JF - European Neuropsychopharmacology. SN - 0924-977X. T2 - 32nd Congress of the European-College-of-Neuropsychopharmacology (ECNP). Y2 - 7 September 2019 through 10 September 2019. ER - ...
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The objective of this study is to assess the safety and efficacy of Ocular Iontophoresis with Dexamethasone Phosphate 40 mg/mL 7.5 mA-min at 2.5 mA and Ocular Iontophoresis with Dexamethasone Phosphate 40 mg/mL 10.5 mA-min at 3.5 mA compared to placebo for the treatment of the signs and symptoms of dry eye ...
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Cultured skin fibroblasts from patients with cystic fibrosis (CF) are more resistant to dexamethasone toxicity than are normal cells. We now report that, when fibroblasts cultured from obligate CF heterozygotes are exposed to dexamethasone, they have an intermediate survival compared to normal and homozygous CF cells. When dexamethasone survival was tested on cells from four patients undergoing amniocentesis, cells from a woman at risk of producing a child with CF showed significant dexamethasone resistance, similar to that of fibroblasts derived from lnown CF homozygotes; the other amniotic cell specimens showed dexamethasone sensitivity similar to that of normal skin fibroblasts. These data suggest that the dexamethasone resistance previously observed in skin fibroblasts may also be useful in the prenatal diagnosis of CF. ...
Dexamethasone Sodium Phosphate is indicated as a rapid adrenal glucocorticoid and/or anti-inflammatory agent. Each ml contains 4 mg dexamethasone sodium phosphate, equivalent to 3 mg dexamethasone. Dexamethasone is a synthetic corticosteroid and possesses
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Therefore, taking dexamethasone should reduce ACTH level and lead to a decreased cortisol level. The diagnosis of Cushings syndrome: An Endocrine Society Clinical Practice Guideline. Healthline Media does not provide medical advice, diagnosis, or treatment. 2. You can get abnormal results mainly due to a tumor in your pituitary gland that produces ACTH, adrenal tumor that releases cortisol, or tumor in the body that leads to the excessive production of ACTH.In this situation, you will have to go for the high-dose test if you havent already done it. Give dexamethasone over 48 hours in doses of 0.5 mg, beginning at 9 AM on day one, at six-hour intervals for a total of eight doses. Procedure: High dose dexamethasone suppression test. An ACTH blood test may tell more about certain causes of high cortisol levels.Even if you have Cushing syndrome, you may get different results depending on the condition thats causing the problem.Even when your test gives abnormalresult, your doctor may still order ...
Although dexamethasone may be a beneficial adjunct to surgery in terms of its antiemetic and anti-inflammatory effects, a team of researchers from Thomas Jefferson University Hospital has found that it may have a darker side, particularly in diabetic patients.. A pilot study concluded that dexamethasone administration was associated with significant postoperative hyperglycemia in these patients when undergoing functional endoscopic sinus surgery (FESS), which ultimately may lead to poorer outcomes.. Dexamethasone is routinely requested by our ENT [ear, nose and throat] surgeons, said Adam Setren, MD, a resident at Thomas Jefferson University Hospital, in Philadelphia. From the anesthesia literature, we know it is a key component in the prevention of nausea and vomiting. From a surgical perspective, theres a commonly held conception-and some evidence to suggest-that it improves operating conditions, decreases inflammation, and may be associated with decreased bleeding and operative times, ...
This study was planned to determine whether a short period dexamethasone treatment induce alveolar bone loss or not, therefore, twenty six male albino rabbits were divided into three groups as follow: Test groups I (10 rabbits) received 1.56 mg/kg dexamethasone intraperitoneal injection daily for two weeks, test group II (10 rabbits) received 3.12 mg/kg dexamethasone intraperitoneal injection daily, and the control group (6 rabbits) received saline solution for same period. The animals were sacrificed and histological sections were prepared from the alveolar bone of molar areas of mandible, as well as morphometric analysis of osteoclasts number was performed. The results showed a significant increase in the number of osteoclasts, which indicates that bone loss, is quite inevitable secondary to dexamethasone treatment even in a short period of treatment for two weeks.
Among patients with glioblastoma receiving an immune checkpoint inhibitor, those who received the corticosteroid dexamethasone at baseline for cerebral edema…
Acute and sub chronic effects of oral dexamethasone on anxiety and memory in mice were evaluated using the elevated plus maze, Y maze and radial arm maze. Adult male Swiss albino mice assigned to five groups were given vehicle (normal saline), a standard drug (Diazepam or Scopolamine) or one of three selected doses of dexamethasone (0.5, 1.0 and 1.5 mg/kg) daily for a period of 14 days. Behavioral tests were carried out on days 1 and 14 after administration. Results were analysed using a one-way ANOVA followed by a posthoc test (Student-Newman-Keul) and expressed as mean ± S.E.M. Elevated plus maze test showed a significant reduction in the time spent in the open arm and in the number of open arm entries compared to control. Results of radial arm and Y maze tasks showed an improvement in spatial memory following dexamethasone administration. Y maze locomotor activity was significantly increased, although radial arm maze exploration did not increase significantly. The study concluded that oral
CAH is a genetic steroidogenesis disorder. The most common form, 21OHD, leads to cortisol deficiency and, in turn, an excess of androgen, a hormone that promotes the development and maintenance of male sex characteristics. As a result of this androgen excess, prepubescent males and newborn, prepubescent, and grown females exhibit mature masculine characteristics. Prenatal treatment with dexamethasone, a corticosteroid that decreases androgen levels, has been shown to prevent the development of abnormal genitalia in female infants. The long-term effects of this treatment, however, have not been evaluated. This study will determine whether prenatal dexamethasone treatment causes any long-term side effects by examining children and young adults who received dexamethasone as fetuses and their mothers, who were exposed to dexamethasone while pregnant.. This study has three parts. In Part 1 of the study, participants will provide written consent for release of their medical records from their ...
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The objective of this study was to evaluate the efficacy of intravenous (i.v.) injection of liposomally encapsulated dexamethasone phosphate (DxM-P) in comparison to free DxM-P in rats with established adjuvant arthritis (AA). This study focused on polyethylene glycol (PEG)-free liposomes, to minimize known allergic reactions caused by neutral PEG-modified (PEG-ylated) liposomes. Efficacy was assessed clinically and histologically using standard scores. Non-specific and specific immune parameters were monitored. Activation of peritoneal macrophages was analyzed via cytokine profiling. Pharmacokinetics/biodistribution of DxM in plasma, synovial membrane, spleen and liver were assessed via mass spectrometry. Liposomal DxM-P (3 × 1 mg/kg body weight; administered intravenously (i.v.) on Days 14, 15 and 16 of AA) suppressed established AA, including histological signs, erythrocyte sedimentation rate, white blood cell count, circulating anti-mycobacterial IgG, and production of interleukin-1beta (IL-1β)
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Dexamethasone Sterile Eye Drops are used in the eye to stop inflammation. They are most commonly used to treat conjunctivitis, episcleritis, scleritis, pannus (chronic superficial keratitis), and eosinophilic keratitis of the cat.
We present a pooled update of two large, multicenter MM-009 and MM-010 placebo-controlled randomized phase III trials that included 704 patients and assessed lenalidomide plus dexamethasone versus dexamethasone plus placebo in patients with relapsed/refractory multiple myeloma (MM). Patients in both studies were randomized to receive 25 mg daily oral lenalidomide or identical placebo, plus 40 mg oral dexamethasone. In this pooled analysis, using data up to unblinding (June 2005 for MM-009 and August 2005 for MM-010), treatment with lenalidomide plus dexamethasone significantly improved overall response (60.6 vs 21.9%, P|0.001), complete response rate (15.0 vs 2.0%, P|0.001), time to progression (median of 13.4 vs 4.6 months, P|0.001) and duration of response (median of 15.8 months vs 7 months, P|0.001) compared with dexamethasone-placebo. At a median follow-up of 48 months for surviving patients, using data up to July 2008, a significant benefit in overall survival (median of 38.0 vs 31.6 months, P=0
TY - JOUR. T1 - Effects of early dexamethasone therapy on pulmonary mechanics and chronic lung disease in very low birth weight infants. T2 - A randomized, controlled trial. AU - Durand, M.. AU - Sardesai, S.. AU - McEvoy, C.. PY - 1995/4/24. Y1 - 1995/4/24. N2 - Objective. To determine the changes in pulmonary mechanics before and during early dexamethasone therapy, and to evaluate the effect of dexamethasone on the duration of mechanical ventilation in very low birth weight (VLBW) ventilator-dependent infants at risk for chronic lung disease (CLD). Methods. A prospective randomized trial was conducted. Forty-three patients (birth weight 600 to 1500 g, gestational age 24 to 32 weeks) who failed to be weaned from the respirator at 7 to 14 days of age were enrolled; 23 infants received a 7-day course of dexamethasone (0.5 mg/kg/day intravenously for 3 days, 0.25 mg/kg/day for 3 days, and 0.1 mg/kg/day for 1 day), and 20 patients were in the control group. At similar mean airway pressure (MAP) and ...
The diagnosis of Cushings syndrome is usually made clinically. However to differentiate between adrenal cause and pituitary cause, tests may be required. The most common screening test to establish increased serum cortisol levels is to do 24 hours urine estimation of free cortisol. Normally, the levels are between 20-70 µg/sqm, however in case of Cushings syndrome, urinary free cortisol is elevated. To find out the cause, your doctor may do blood ACTH levels and high dose dexamethasone suppression test. In case of pituitary tumors, ACTH levels will be elevated. In case of adrenal tumors, ACTH levels will be decreased. High dose dexamethasone tests consists of given high dose dexamethasone 6 hourly for 48 hours and then doing urinary free cortisol on 2nd day. In case of suppression of secretion of cortisol in urine, it suggests a pituitary cause and in case of non suppression, it suggests adrenal cause ...
Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple myeloma regardless of prior thalidomide exposure.
TY - JOUR. T1 - A randomized, double-blind, parallel, comparative study to evaluate the efficacy and safety of ramosetron plus dexamethasone injection for the prevention of acute chemotherapy-induced nausea and vomiting. AU - Ho, Ching Liang. AU - Su, Wu Chou. AU - Hsieh, Ruey Kuen. AU - Lin, Zhong Zhe. AU - Chao, Tsu Yi. PY - 2009/12/20. Y1 - 2009/12/20. N2 - Objective: To evaluate the efficacy of intravenous ramosetron plus dexamethasone for the prevention of acute chemotherapy-induced nausea and vomiting. Methods: Cancer patients scheduled to receive chemotherapy containing either of the four drugs (cisplatin, doxorubicin, epirubicin or oxaliplatin) were enrolled. They were randomized to receive intravenous ramosetron 0.3 mg plus dexamethasone 20 mg or granisetron 3 mg plus dexamethasone 20 mg 30 min before chemotherapy on day 1. The primary efficacy parameter is complete response rate, which was defined by the proportion of patients without vomiting and no requirement for rescue drugs within ...
Background:Dexamethasone may improve multimodal pain management following painful orthopedic day surgery procedures, and decrease the need for post-operative opioids. We hypothesized that dexamethasone would reduce the need for oxycodone after surgical correction of hallux valgus.Methods:Sixty patie
TY - JOUR. T1 - Dexamethasone treatment of calves latently infected with bovine herpesvirus 1 leads to activation of the bICP0 early promoter, in part by the cellular transcription factor C/EBP-alpha. AU - Workman, Aspen. AU - Perez, Sandra. AU - Doster, Alan. AU - Jones, Clinton. PY - 2009. Y1 - 2009. N2 - Sensory neurons within trigeminal ganglia (TG) are the primary site for bovine herpesvirus 1 (BHV-1) latency. During latency, viral gene expression is restricted to the latency-related (LR) gene and the open reading frame ORF-E. We previously constructed an LR mutant virus that expresses LR RNA but not any of the known LR proteins. In contrast to calves latently infected with wild-type (wt) BHV-1 or the LR rescued virus, the LR mutant virus does not reactivate from latency following dexamethasone (DEX) treatment. In this study, we demonstrated that bICP0, but not bICP4, transcripts were consistently detected in TG of calves infected with the LR mutant or LR rescued virus following DEX ...
Results We found 11 papers comparing dexamethasone to prednisolone of which 8 were controlled trials, one was a retrospective cohort study and two were meta-analyses. There was significant heterogeneity of dosage and method of administration of dexamethasone, including intramuscular, nebulised and oral routes. We analysed four controlled studies of oral dexamethasone, as this was our preferred route. Details of the four studies can be found in Table 1. All of the studies found that dexamethasone was non-inferior to prednisolone. One study compared a single 0.6mg/kg dose of dexamethasone with 5 days of prednisolone, two studies compared two daily 0.6mg/kg doses of dexamethasone with 5 days of prednisolone and the most recent study compared a single 0.3mg/kg dose of dexamethasone with 3 days of prednisolone. Most of the studies have some limitations which may affect the validity of the results. ...
The potential advantages of using ultrasound for drug, gene, and protein delivery, using parameters that cause cavitation and streaming effects, have been confirmed in different experimental studies [24, 28, 32]. Cavitation is known as the creation, oscillation, and collapse of gas bubbles due to acoustic waves [33-35]. It is stated to be the main mechanism responsible for promoting drug delivery through the skin [32, 36]. There are two types of cavitation: stable and inertial. Stable cavitation is defined as the uniform pulsation of bubbles over long time intervals [33], and the oscillation of these bubbles can produce mechanical stresses that may cause cell membrane rupture [37]. In the case of inertial cavitation, collapse of the bubbles causes shock waves and microjets to be generated near the cells, thus producing pits in the cell membranes [38, 39]. The effect of inertial cavitation is greater at lower frequencies because bubbles have more time to grow, which results in a more violent ...
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TY - JOUR. T1 - Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells. AU - Tome, Margaret E.. AU - Jaramillo, Melba C.. AU - Briehl, Margaret M.. PY - 2011/12/1. Y1 - 2011/12/1. N2 - Glucocorticoid-induced apoptosis is exploited clinically for the treatment of hematologic malignancies. Determining the required molecular events for glucocorticoid-induced apoptosis will identify resistance mechanisms and suggest strategies for overcoming resistance. In this study, we found that glucocorticoid treatment of WEHI7.2 murine thymic lymphoma cells increased the steady-state [H 2O 2] and oxidized the intracellular redox environment before cytochrome c release. Removal of glucocorticoids after the H 2O 2 increase resulted in a 30% clonogenicity; treatment with PEG-CAT increased clonogenicity to 65%. Human leukemia cell lines also showed increased H 2O 2 in response to glucocorticoids and attenuated apoptosis after PEG-CAT treatment. WEHI7.2 cells that overexpress ...
We examined the direct effects of glucocorticoid treatment on neutrophil survival and function in vitro. Four different glucocorticoids caused a dose-dependent inhibition of apoptosis leading to increased survival of neutrophils. Maximal effects were found with dexamethasone at 10(-6) M, 16.6 +/- 6.2 vs 54.6 +/- 6.9, at 24 h (p , 0.05). Nonglucocorticoid steroids did not modulate apoptosis in neutrophils. Furthermore, the effect was inhibited in a dose-dependent manner by the glucocorticoid antagonist RU 486. Glucocorticoid-treated neutrophils produced significantly more superoxide in response to FMLP than untreated controls (p , 0.05). However, both basal and stimulated superoxide production were less than that found with freshly isolated cells. Such lack of priming or activation by glucocorticoids is in contrast to previous experience when increased survival was accompanied by cell activation. When compared with other stimuli, the effect of glucocorticoids at 24 h was similar to that of LPS ...
Glucocorticoids are commonly used in treatment of paediatric diseases, but evidence of associated adverse cerebral effects is accumulating. The various pharmacokinetic profiles of the exogenous glucocorticoids and the changes in pharmacodynamics during childhood, result in different exposure of nervous tissue to exogenous glucocorticoids. Glucocorticoids activate two types of intracellular receptors, the mineralocorticoid receptor and the glucocorticoid receptor. The two receptors differ in cerebral distribution, affinity and effects. Exogenous glucocorticoids favor activation of the glucocorticoid receptor, which is associated with unfavorable cellular outcomes. Prenatal treatment with glucocorticoids can compromise brain growth and is associated with periventricular leukomalacia, attentions deficits and poorer cognitive performance. In the neonatal period exposure to glucocorticoids reduces neurogenesis and cerebral volume, impairs memory and increases the incidence of cerebral palsy. Cerebral ...
We have recently found that ketoconazole inhibits adrenal steroidogenesis; in this paper we investigated whether imidazole antimycotic drugs additionally interact with glucocorticoid receptor sites in target tissues. Our approach was to assess the ability of three drugs: ketoconazole, clotrimazole, and RS 49910, to inhibit [3H]dexamethasone binding to hepatoma tissue culture (HTC) cell cytosol. The results indicated dose-dependent, competitive displacement of [3H]dexamethasone binding that was in the potency sequence: clotrimazole greater than ketoconazole greater than RS 49910. We then examined the functional response of this binding by measuring tyrosine aminotransferase (TAT) activity in HTC cells. The antimycotics did not exhibit TAT agonist activity and inhibition of basal enzyme levels was not detected. However, the drugs were potent antagonists of dexamethasone-induced TAT activity and the effect was temporally reversible. This antagonist activity was in the same sequence and closely ...
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Insufficient production of pulmonary surfactant in alveolar type II cells is relevant to many lung diseases. To cure its deficiency, glucocorticoid is commonly used in clinical areas. In the present study, we investigated the effect of dexamethasone on the secretion of phosphatidylcholine, a major phospholipid of pulmonary surfactant, in a primary culture of rat alveolar type II cells. Dexamethasone had no effect on the basal secretion rate of phosphatidylcholine. Dexamethasone augmented both the phosphatidylcholine secretion and the cyclic AMP formation increased by terbutaline. Furthermore, dexamethasone increased the number of β-adrenoceptors and mRNA expression of β,SUB,2,/SUB,-adrenoceptors in type II cells. These findings indicate that dexamethasone increases pulmonary surfactant secretion through an enhancement of β,SUB,2,/SUB,-adrenoceptor gene expression.. ...
1. High dose dexamethasone testing. For more than 30 yr HDDST has remained one of the main biochemical tools used in the differential diagnosis of ACTH-dependent Cushings syndrome. The basis of the test relies on the fact that, in most situations, the corticotroph tumor cells in Cushings disease retain some responsiveness to the negative feedback effects of glucocorticoids while tumors ectopically secreting ACTH do not. The standard test was performed on 24-h collections of urine for the measurement of 17-OHCS or UFC, calculating the degree of suppression from day 1 to day 3 after the administration of oral dexamethasone at a dose of 2 mg every 6 h for 48 h. As with the LDDST, several suppression cut-offs that optimally define pituitary disease, in addition to combinations of measurements of different steroids, have been reported. Originally, suppression of urinary 17-OHCS by 50% or greater was reported as being consistent with Cushings disease (60). Although this criterion has no intrinsic ...
President Donald Trumps condition was more serious than originally reported when he went to hospital on Friday evening after testing positive for coronavirus, reports said.. The White House initially said Trump was experiencing mild symptoms of Covid-19, but Trumps chief of staff Mark Meadows told reporters, The Presidents vitals over the last 24 hours were very concerning and the next 48 hours will be critical in terms of his care. We are still not on a clear path to a full recovery, he added.. One of the physicians treating Trump later said that he was treated with the steroid Dexamethasone after oxygen level dropped for two days. White House physician Sean P. Conley then confirmed it.. Dexamethasone is not a drug that is usually given in the mild stage of the disease.. There are reports that the president was doing well and might be discharged from Walter Reed national Military Medical Center in Bethesda, Md, on Monday.. The President has no public events scheduled for Monday, according ...
Treatments of brain tumor associated edema with systemically delivered dexamethasone, the standard of care, and cediranib, a novel anti-edema agent, are associated with systemic toxicities in brain tumor patients. A tunable, reservoir-based drug delivery device was developed to investigate the effects of delivering dexamethasone and cediranib locally in the brain in an intracranial 9 L gliosarcoma rat model. Reproducible, sustained releases of both dexamethasone and solid dispersion of cediranib in polyvinylpyrrolidone (AZD/PVP) from these devices were achieved. The water-soluble AZD/PVP, which exhibited similar bioactivity as cediranib, was developed to enhance the release of cediranib from the device. Local and systemic administration of both dexamethasone and cediranib was equally efficacious in alleviating edema but had no effect on tumor growth. Edema reduction led to modest but significant improvement in survival. Local delivery of dexamethasone prevented dexamethasone-induced weight loss, ...
5-fluorouracil and steroids have been used to suppress excessive scar formation after glaucoma filtering surgery (GFS). Steroidal and nonsteroidal antiinflammatory drugs (NSAIDs), which are inhibitors of arachidonic acid (AA) pathway, both limit fibroblast activity and reduce inflammation. In this experiment, the ability of corticosteroid (dexamethasone sodium phosphate), cyclooxygenase inhibitor (piroxicam), lipoxygenase inhibitor (ferulic acid), and dual cyclo/lipoxygenase inhibitor (phenidone) to inhibit human Tenons fibroblast proliferation was evaluated in culture. After human Tenons fibroblast cell lines were established, a complete dose-response curve was done for the representative compounds for 8 days. Fibroblast attachment and proliferation were quantified by Coulter counter, hexosaminidase, and tritiated thymidine uptake assays. All four drugs inhibited attachment and proliferation at high concentrations. Phenidone was the most effective, with inhibition occurring within the ...
Alternative splicing of the human glucocorticoid receptor (hGR) pre-mRNA generates two highly homologous isoforms, termed hGR alpha and hGR beta. hGR alpha is a ligand-activated transcription factor which, in the hormone-bound state, modulates the expression of glucocorticoid-responsive genes by binding to specific glucocorticoid response element (GRE) DNA sequences. In contrast, hGR beta does not bind glucocorticoids and is transcriptionally inactive. We demonstrate here that hGR beta is able to inhibit the effects of hormone-activated hGR alpha on a glucocorticoid-responsive reporter gene in a concentration-dependent manner. [3H]-Dexamethasone binding studies indicate that hGR beta does not alter the affinity of hGR alpha for its hormonal ligand. The presence of hGR beta in nuclear extracts and its ability to bind to a radiolabeled GRE oligonucleotide suggest that its inhibitory effect may be due to competition for GRE target sites. Reverse transcription-PCR analysis shows expression of hGR ...
Dexamethasone Ampoules Composition: Each ampoule (2 ml) contains: Dexamethasone sodium phosphate (equivalent to 8 mg Dexamethasone). Properties and Mechanism of Action: Dexamethasone is a synthetic […]. ...
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Background: The incidence of post-operative nausea and vomitting (PONV) is increased after middle ear surgery and it may complicate and interact with reconstruction after surgery, so prevention and treatment of these complications are necessary. The aim of this study was to evaluate the efficacy of anti-emetic combinations in decreasing the PONV after middle ear surgery. Materials and methods: This double blind clinical trial was carried out during 2007-2008 on 111 patients of 15-45 years old with ASA I-II who were candidates for elective middle ear surgery under general anesthesia. The patients were divided into three groups. Patients in the ON group received Ondansetrone 0.1mg/kg + Nacl 0.9% 2cc, OD group received Ondansetrone 0.1mg/kg + Dexamethasone 0.15mg/kg and MD group received Dexamethasone 0.15mg/kg+ Metoclopramide 0.15mg/kg intravenously just before the end of surgery. The patients were evaluated for nausea, vomiting, need of anti-emetic drugs and drug dosage in recovery, 1-6, 6-12 and 12-24
CHILDREN with croup start to improve within 30 minutes of receiving an oral corticosteroid, which is much faster than previously thought, according to new Australian research.. The double-blind trial involved 70 children presenting with croup to the emergency department at Princess Margaret Hospital for Children in Perth. They were randomly assigned to receive either placebo or 0.15mg/kg dexamethasone immediately on presentation. After 1 hour, all children received 0.15mg/kg dexamethasone.. After 10 minutes, the Westley croup scores of the children in the immediate dexamethasone treatment group were already trending lower than those in the placebo group. By 30 minutes, the difference in croup scores had reached statistical significance.. The results were presented at last weeks annual scientific meeting of the Australasian College for Emergency Medicine held in Sydney.. The study found thatdexamethasone for croup worked much faster than reported by a recent Cochrane Review, which stated that ...
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Pain after orthopedic surgery can be intense. Many anesthesia providers and orthopedic surgeons support the use of peripheral nerve blockade to assist in decreasing the amount of pain a patient may experience post operatively. Select medication adjuncts are being added to peripheral nerve blocks to prolong analgesia. The research presented here focuses on the addition of dexamethasone to peripheral nerve blocks to prolong analgesia. Dexamethasone is a synthetic glucocorticoid that acts as an anti-inflammatory. It has been shown to inhibit the release of inflammatory mediators such as, interleukins and cytokines, facilitating the release of anti-inflammatory mediators, decreasing postoperative pain. Recent evidence demonstrates a potential role of dexamethasone in postoperative pain management, both as a systemic analgesic and as an adjunct to local anesthetics for perineural use. A single preoperative dose of dexamethasone has been shown to be an effective adjunct to reduce postoperative pain and opioid
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TY - JOUR. T1 - Influence of pyramid environment on the wound healing effects of dexamethasone and indomethacin - a comparative study. AU - Surekha, Kamath. PY - 2011/12/1. Y1 - 2011/12/1. N2 - Shapes and angles of The Great Pyramid of Egypt are balanced and renowned for their energy properties. Studies have proved that beneficial effects are found on human health in pyramidal environment. The present study was designed to determine the efficacy of dexamethasone and indomethacin on incision and dead space wound models in rats under the influence of pyramid environment. A wooden pyramid model fabricated locally was used for the study. The parameters chosen were breaking strength of incised wound, breaking strength of granulation tissue, hydroxyproline content and histology. The results showed that the dexamethasone and indomethacin slow down all phases of wound healing and the inhibitory action of dexamethasone on wound healing was stronger than that of indomethacin. Thus pyramid exposure ...
Nausea and vomiting continue to be distressing side effects of cancer chemotherapy. We recently reported (1) a randomized, double-blind study in which a single 10-mg dose of intravenous dexamethasone markedly reduced the gastrointestinal side effects of mildly emetogenic chemotherapy for outpatients with breast cancer. We now report the safety and efficacy of repeated doses of dexamethasone in eliminating the nausea and vomiting of induction chemotherapy for patients with acute nonlymphocytic leukemia.. All patients included in the study were adults with acute nonlymphocytic leukemia (at diagnosis or on relapse) at the Hospital of the University of Pennsylvania and were treated with ...
We used a dominant inhibitory mutation of c-Ha-ras which changes Ser-17 to Asn-17 in the gene product p21 [p21(Asn-17)Ha-ras] to investigate ras function in mitogenic signal transduction. An NIH 3T3 cell line [NIH(M17)] was isolated that displayed inducible expression of the mutant Ha-ras gene (Ha-ras Asn-17) via the mouse mammary tumor virus long terminal repeat and was growth inhibited by dexamethasone. The effect of dexamethasone induction on response of quiescent NIH(M17) cells to mitogens was then analyzed. Stimulation of DNA synthesis by epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) was completely blocked by p21(Asn-17) expression, and stimulation by serum, fibroblast growth factor, and platelet-derived growth factor was partially inhibited. However, the induction of fos, jun, and myc by EGF and TPA was not significantly inhibited in this cell line. An effect of p21(Asn-17) on fos induction was, however, demonstrated in transient expression assays in which ...
Wildlife Welfare: The effect of park management factors on glucocorticoid receptor levels in the hippocampus and cortisol levels in hair of fallow deer (Dama dama) from wildlife parks in the UK and in the Netherlands as indicators for chronic ...
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The combination of the investigational histone deacetylase inhibitor panobinostat (Faridak) with bortezomib (Velcade) and dexamethasone was able to recapture responses in 34.5% of heavily pretreated, bortezomib-refractory patients with multiple myeloma in the phase II PANORAMA 2 trial. The 55 patients enrolled at 12 trial sites had a median of four prior regimens, including two prior regimens with bortezomib. The responses at the end of the first treatment phase cycles included 1 near-complete response and 18 partial responses. An additional 10 patients achieved minimal response, for a clinical benefit rate of 52.7%, reported Paul G. Richardson, MD, of Dana-Farber Cancer Institute and Harvard Medical School, Boston, and colleagues. The investigators published their results online in Blood.. Responses in the remainder of patients consisted of stable disease in 20 patients (36.4%) and progressive disease in 3 patients (5.5%). Response could not be assessed in the remaining 3 patients (5.5%) due ...
Large parenteral doses of dexamethasone were given to five of ten cats after transorbital occlusion of one middle cerebral artery and to two of four cats after sham operations. Two days later the water content and brain/blood ratios of pertechnetate were measured in samples of cerebral tissue that were categorized as nonischemic, ischemic, or infarcted. Values for infarcted tissue were greater than those for ischemic tissue in untreated cats, but not in cats that received dexamethasone. The drug had no apparent effect in ischemic tissue that was not necrotic. These results help explain inconsistencies in previous studies and help define the potential usefulness of dexamethasone for treatment of cerebrovascular disease.. ...
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Synovial tissue cells from patients with seropositive rheumatoid arthritis bind dexamethasone in a similar fashion to the classical steroid receptors on other cells. In contrast, synovial fluid cells...
BACKGROUND: Peripheral nerve block (infiltration of local anaesthetic around a nerve) is used for anaesthesia or analgesia. A limitation to its use for postoperative analgesia is that the analgesic effect lasts only a few hours, after which moderate to severe pain at the surgical site may result in the need for alternative analgesic therapy. Several adjuvants have been used to prolong the analgesic duration of peripheral nerve block, including perineural or intravenous dexamethasone. OBJECTIVES: To evaluate the comparative efficacy and safety of perineural dexamethasone versus placebo, intravenous dexamethasone versus placebo, and perineural dexamethasone versus intravenous dexamethasone when added to peripheral nerve block for postoperative pain control in people undergoing surgery ...
We tested the effects of DP on erythroid and granulocyte-macrophage colony formation in progenitor cells from preterm infants and adults. The concentrations of DP included in the culture dishes ranged from 10−6 M to 10−9M. Studies on the pharmacokinetics of DP in preterm infants have shown that the plasma concentrations reached following DP administrations are in the order of magnitude of 10−6 M to 10−8M.7 It is not known, however, whether these concentrations will be achieved in the bone marrow, nor whether interactions with other hormones or mediators in the bone milieu will influence the effect of DP on haematopoietic progenitors. In our experimental conditions DP showed a dose dependent inhibitory effect on both erythroid and granulocyte-macrophage colonies derived from progenitor cells of preterm infants. CFU-E colonies were the most affected, with significant reductions observed at all concentrations of DP. This profound reduction in erythroid colonies was not apparent with bone ...
Read Dexamethasone treatment in vitro resulted in different responses of two fractions of phagocytes of the holothurian Eupentacta fraudatrix, Russian Journal of Marine Biology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
We have demonstrated the dexamethasone sodium phosphate (DmNaP) is delivered most efficiently from the negative electrode by iontophoresis, but, under certain conditions, the delivery from the positive electrode by electroosmosis can be accomplished. The laboratory data indicate that more dexamethasone is delivered per mA-min by iontophoresis than by electtoomosis, thus the same amount of drug can be administered in a shorter time from the negative electrode. Electrodes containing a hydrogel material, which restricts bulk water transport, delivered DmNaP most efficiently from the electrode of a negative polarity. When DmNaP is to be delivered in a mixture with another drug such as lidocaine, selection of the clinical treatment protocol depends on the desired therapeutic effect on the iontophoreic electrode which is to be used. When minimization of total treatment time is not critical, switching polarity of the electrode during the treatment can be used to administer drugs of opposite polarity ...
There are no specific protocols for Human Glucocorticoid Receptor alpha peptide (ab39764). Please download our general protocols booklet
The study was conducted under the supervision of Associate Professor Samuel and Dr Simon Royce of the Monash Lung Biology Network,1 focusing on the effects of CymerusTM MSCs in combination with or in comparison to the corticosteroid dexamethasone, which is commonly used to treat exacerbations of asthma in human patients. The study used a well-established mouse model of chronic allergic airways disease that closely resembles asthma in humans. This part of the study focused on airway hyperresponsiveness (AHR), which is a key clinical manifestation of asthma.. Initial results from this study have demonstrated that, as expected, treatment with dexamethasone alone significantly improved AHR compared to untreated controls (p,0.05). However, treatment with either Cymerus™ MSCs alone, or Cymerus™ MSCs in combination with dexamethasone, resulted in a substantially greater suppression of AHR, which was significantly superior to that seen with dexamethasone treatment alone (p,0.01). All treatments were ...
Cico S. Cico S Cico, Stephen John.. Single Dose Oral Dexamethasone for Pediatric Asthma - Is It an Alternative to the 5-day Prednisone or Prednisolone Burst?. To the Point: Clinical Reviews Tintinalli JE. Tintinalli J.E. Tintinalli, Judith E. New York, NY: McGraw-Hill, 2016, http://accessemergencymedicine.mhmedical.com/updatesContent.aspx?gbosid=367734§ionid=159414917. ...
TY - JOUR. T1 - Glucocorticoid receptor in polymorphonuclear leukocytes. T2 - A simple method for leukocyte glucocorticoid receptor characterization. AU - Murakami, Tohru. AU - Brandon, David. AU - Rodbard, David. AU - Loriaux, Donald (Lynn). AU - Lipsett, Mortimer B.. PY - 1979. Y1 - 1979. N2 - Glucocorticoid receptors of polymorphonuclear leukocytes (PMN) have been characterized and compared with those of mononuclear leukocytes (MNL). Cytosol receptors from PMN and MNL have similar binding affinities for [3H]-dexamethasone (Dex). nearly superimposable sedimentation profiles on sucrose density gradients, and similar elution patterns from DEAE-Sephadex. Thus, the glucocorticoid receptors of MNL and PMN have similar biochemical properties. We have developed a simple method for preparing leukocytes from 20 ml of blood to characterize and quantify the glucocorticoid receptor. The Scatchard analysis of [3H]-Dex binding to intact leukocytes shows a single class of binding sites; the apparent Kd was ...
This work is composed by two parts that will be presented separately as follows: Assessment of swelling of PLGA based implants and drug release at the site of administration: The aim of this study was to investigate the counter-pressure of adipose tissue. Force-distance curves were used to measure the required force to squeeze out a certain volume of water in the balloon. Three catheters with different volumes were placed in the air and in the tissue (chicken and pork tissue). The counter-pressure of adipose tissue on implants was higher as bigger as the implants were. Implant formulations which tend to swell more, will be more suppressed by surrounding tissue at the site of administration and, consequently, the drug release of these formulations will decrease. Thus, the swelling of PLGA based implants and drug release at the site of administration were investigated. Two different loading of dexamethasone sodium phosphate implants were prepared (10% and 30%). The implants containing 10% and 30% ...
The effects of dexamethasone are frequently seen within a day and last for about three days. The long-term use of dexamethasone ... Dexamethasone has also been used with antibiotics to treat acute endophthalmitis. Dexamethasone is used in transvenous screw-in ... Dexamethasone suppression test "Dexamethasone Use During Pregnancy". Drugs.com. Archived from the original on 17 May 2016. ... "Dexamethasone". 17 June 2020. Archived from the original on 1 October 2020. Retrieved 18 June 2020. "Dexamethasone in COVID-19 ...
... is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Morton IK, Hall JM (1999). " ... "Dexamethasone acefurate". Concise Dictionary of Pharmacological Agents : Properties and Synonyms. Dordrecht: Springer ...
... is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. In China, 999 sells it under the ...
... is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by ...
... but inhibition of cortisol on high-dose dexamethasone. If the cortisol levels are unchanged by low- and high-dose dexamethasone ... The dexamethasone suppression test (DST) is used to assess adrenal gland function by measuring how cortisol levels change in ... The test is given at low (usually 1-2 mg) and high (8 mg) doses of dexamethasone, and the levels of cortisol are measured to ... Dexamethasone is an exogenous steroid that provides negative feedback to the pituitary gland to suppress the secretion of ...
"Dexamethasone". drugs.com. Archived from the original on 21 June 2013. Retrieved 14 June 2013. Caldato MC, Fernandes VT, Kater ... Compared to hydrocortisone, prednisolone is about 4 times as potent and dexamethasone about 40 times as potent in terms of anti ...
... or dexamethasone. Rapid injection of one of these drugs may stop a severe allergic reaction. Multiple sclerosis patients may ...
... and that dexamethasone and ondansetron (a commonly used combination) are two of the most effective anti-emetics for PONV. The ... Medications include dexamethasone. Butyrophenones are typically administered as a single injection at the end of surgery. ... ondansetron or dexamethasone) or other drugs including tropisetron, dolasetron, cyclizine, and granisetron. Droperidol may ...
... dexamethasone in ARDS network (2020). "Dexamethasone treatment for the acute respiratory distress syndrome: A multicentre, ... One study found that dexamethasone may help. The combination of hydrocortisone, ascorbic acid, and thiamine also requires ...
"Dexamethasone Uses, Dosage & Side Effects". "Ampicillin Uses, Side Effects & Warnings". Munoz, P.; Sainz, J.; Rodriguez- ... Earlier studies suggest that dexamethasone improved the outcome of adults with pneumococcal meningitis. In a specific case ... study, a patient who had symptoms of a fever and headache was treated with cefotaxime, ampicillin, and dexamethasone and had to ...
"Tobradex- tobramycin and dexamethasone ointment". DailyMed. 11 September 2019. Retrieved 28 April 2020. "Tobradex- tobramycin ... Eye drops and ointments (tobramycin only, Tobrex, or combined with dexamethasone, sold as Tobradex) and nebulised formulations ... and dexamethasone suspension/ drops". DailyMed. 9 September 2019. Retrieved 28 April 2020. "Tobramycin- tobramycin sulfate ...
"Q&A: Dexamethasone and COVID-19". World Health Organization. Retrieved 11 July 2020. "Home". National COVID-19 Clinical ... In those with low oxygen levels, use of the glucocorticoid dexamethasone is recommended, to reduce mortality. Noninvasive ...
May 1997). "Dexamethasone stimulates leptin release from human adipocytes: unexpected inhibition by insulin". Journal of ... Leptin release is increased by dexamethasone. In obese patients with obstructive sleep apnea, leptin level is increased, but ...
Dexamethasone is the corticosteroid of choice. Although neurological symptoms may improve within 24 to 72 hours of starting ...
The Japanese Health Ministry approved the use of dexamethasone to treat moderate or advanced cases of COVID-19, after trials ... Wong, Jacqueline (22 July 2020). "Japan approves dexamethasone as coronavirus treatment". Reuters. Archived from the original ...
GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK. Many ...
In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal ... "Trichlormethiazide and Dexamethasone for veterinary use". Wedgewood Pharmacy. Retrieved 2008-01-24. GB 949373, "Benzthiadiazine ...
de Gans J, van de Beek D (November 2002). "Dexamethasone in adults with bacterial meningitis". The New England Journal of ... McIntyre PB, Berkey CS, King SM, Schaad UB, Kilpi T, Kanra GY, Perez CM (September 1997). "Dexamethasone as adjunctive therapy ... Additional treatment with corticosteroids (usually dexamethasone) has shown some benefits, such as a reduction of hearing loss ... Professional guidelines therefore recommend the commencement of dexamethasone or a similar corticosteroid just before the first ...
Dreger, A; Feder, E.K.; Tamar-Mattis, A (Jul 2012). "Prenatal Dexamethasone for Congenital Adrenal Hyperplasia: An Ethics ... ". "Medical Ethics: Prenatal Dexamethasone Use Questioned". Time. 18 June 2010. Slate "If Your Baby Girl Might Be Born With a ...
De Kloet ER (October 1997). "Why Dexamethasone Poorly Penetrates in Brain". Stress. 2 (1): 13-20. doi:10.3109/10253899709014734 ... and dexamethasone, among others. α-Methylserotonin - a serotonin receptor agonist Alvimopan - a μ-opioid receptor antagonist ... a non-sedating antihistamine Dexamethasone - a glucocorticoid with some peripheral selectivity Digoxin - a cardiac glycoside ...
"Q&A: Dexamethasone and COVID-19". World Health Organization (WHO). Archived from the original on 11 October 2020. Retrieved 11 ... As of November 2020 use of the glucocorticoid dexamethasone had been strongly recommended in those severe cases treated in ... As of February 2021, in the European Union, the use of dexamethasone and remdesivir were authorized. Despite being ... As of August 2021, there was moderate-certainty evidence suggesting that dexamethasone, and systemic corticosteroids in general ...
Intravitreal injection of Dexamethasone implant (Ozurdex; 700,350 μg) is being studied, its effect may last for 180 days. The ... December 2011). "Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein ...
Common corticosteroids include dexamethasone and betamethasone. Dexamethasone is often recommend over the latter due to its ... Liggins found that dexamethasone caused pregnant sheep to deliver their fetuses prematurely, however, despite the fact that the ... December 2020). "Antenatal Dexamethasone for Early Preterm Birth in Low-Resource Countries". The New England Journal of ... "Dexamethasone versus betamethasone as an antenatal corticosteroid (ACS)" (PDF). UN Commission / Born Too Soon Care Antenatal ...
"Welcoming early results on use of dexamethasone in sickest COVID-19 patients, WHO warns it's 'no cure-all'". UN News. 17 June ... The World Health Organization welcomed early results on use of dexamethasone in sickest COVID-19 patients, while warning it's ' ... Mukherjee, Promit (23 June 2020). "S. Africa's Aspen says it has capacity to meet demand for dexamethasone". Reuters. Archived ... Roberts, Michelle (16 June 2020). "Coronavirus: Dexamethasone proves first life-saving drug". BBC. Archived from the original ...
In November 2016, the FDA approved daratumumab in combination with lenalidomide or bortezomib and dexamethasone for the ... August 2016). "Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma". The New England Journal of Medicine. 375 (8): ... October 2016). "Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma". The New England Journal of Medicine. 375 ( ... as well as with bortezomib and dexamethasone.[needs update] In November 2015, the U.S. Food and Drug Administration (FDA) ...
Anías-Calderón, José; Verdugo-Díaz, Leticia; Drucker-Colín, René (2004). "Adrenalectomy and dexamethasone replacement on ...
"Dokter Reisa: Dexamethasone Bukan Penangkal COVID-19". Indonesian National Board for Disaster Management and COVID-19 Response ...
Pullulan-dexamethasone bioconjugates have been created which also exhibit self-assembling nanoparticles that have an ... Pharmacokinetic analysis was performed on this bioconjugate system and revealed that dexamethasone was released in the vitreous ... The study synthesized self-assembling pullulan nanoparticles with dexamethasone attached through hydrazone bonds. This study ... Further studies have investigated the creation and efficacy of pullulan-dexamethasone bioconjugates for intravitreal injections ...
Symonds, C. P.; Harris, PW; Lessof, MH; Lyne, C (1943). "Singledose dexamethasone suppression test for Cushing's Syndrome". BMJ ...
Dexamethasone was closed to new adult entries after positive results and by November 2020, was open to child entries. Launched ... "Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID ... "Dexamethasone reduces death in hospitalised patients with severe respiratory complications of COVID-19". University of Oxford. ... In a controlled trial around 2,000 hospital patients were given dexamethasone and were compared with more than 4,000 who did ...
Dexamethasone: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking dexamethasone,. *tell your doctor and pharmacist if you are allergic to dexamethasone, aspirin, tartrazine (a ... Dexamethasone may cause an upset stomach. Take dexamethasone with food or milk. ... If you take dexamethasone once a day, take the missed dose as soon as you remember it. However, if it is almost time for the ...
CHICAGO - Dexamethasone/povidone-iodine ophthalmic suspension (SHP640) effectively treated viral conjunctivitis in a randomized ... Cite this: Dexamethasone/Povidone-Iodine Effective for Conjunctivitis - Medscape - Oct 11, 2017. ... It combines a broad-spectrum antiseptic (povidone-iodine, 0.6%) and an anti-inflammatory steroid (dexamethasone, 0.1%). ...
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Buy Dexamethasone Tablets and other Allergy Relief from top brands at 1800PetMeds and save. Free shipping on orders over $49! ...
Drug Information available for: Dexamethasone Dexamethasone sodium phosphate Dexamethasone acetate Lenalidomide Isatuximab ... Active Comparator: Lenalidomide and dexamethasone (Ld) Lenalidomide PO administration on Days 1 to 21 and dexamethasone PO ... in Combination With Lenalidomide and Dexamethasone Versus Lenalidomide and Dexamethasone in Patients With High-risk Smoldering ... in Combination With Lenalidomide and Dexamethasone Versus Lenalidomide and Dexamethasone in Patients With High-risk Smoldering ...
Qorichi baayee rakasa taeefi salphaatti argamuu dandau dexamethasone jedhamu dhukkubsattoota Covid-19 haala yaaddessaa ... Deksaametaazoon [Dexamethasone] bara 1960ta jalqabaarraa kaasee hoiirra oolaa jira. Qorichi kun dhibeen fayyaa gara garaa kan ...
Active Comparator: Dexamethasone dexamethasone single agent. Drug: Dexamethasone 4 mg tablet. 40 mg orally on Day 1, 8, 15 and ... Drug Information available for: Dexamethasone Dexamethasone sodium phosphate Dexamethasone acetate Genetic and Rare Diseases ... Experimental: Plitidepsin+Dexamethasone plitidepsin + dexamethasone combination. Drug: Plitidepsin plitidepsin: powder and ... To compare the efficacy of plitidepsin in combination with dexamethasone vs. dexamethasone alone as measured by progression- ...
... dexamethasone data, pregnancy loss and more in this weeks COVID Booster. ... The steroid dexamethasone has been gaining interest as a treatment for severe COVID-19, with growing evidence that it can ... "As dexamethasone is cheap, easily available and indicated for the treatment of COVID-19 patients with critically low oxygen ... "Whilst the data do not provide unequivocal evidence that dexamethasone 12mg is better than 6mg, we saw a trend towards reduced ...
FDA analysis has found the product to be tainted with diclofenac and dexamethasone. Diclofenac and dexamethasone are both FDA ... Consumption of undeclared dexamethasone may lead to severe and serious adverse events such as adrenal suppression, a disorder ... The presence of diclofenac and dexamethasone in Artri King Reforzado con Ortiga y Omega 3 renders it an unapproved drug for ... FDA Alert: Dietary Supplement Marketed for Pain Relief Recalled Due to Presence of Diclofenac and Dexamethasone June 15, 2022 ...
Dexamethasone Dexamethasone. Medicine Status PIL SPC XPIL Legal Category Active Ingredient(s) Company Dexamethasone 2mg Tablets ...
Dexamethasone. The Anatomical Therapeutic Chemical (ATC) classification system from Drugs-about.com includes all drugs ... S02BA06 - Dexamethasone *Dexamethasone ATC Classification , Home Page , Sitemap , Terms & Conditions , Privacy Policy , Pharma ...
"If dexamethasone works well in humans, we could potentially use it to prevent fearful memories in soldiers on the battlefield, ... "A treatment like dexamethasone is very appealing because it has very few side-effects and is inexpensive," Galatzer-Levy says ... They found that dexamethasone, a widely prescribed steroid for inflammatory conditions, affects the expression of fkbp5 in the ... Dexamethasone Affects fkbp5 Gene That Helps Prevent Post Traumatic Stress Disorder Personalised Printable Document (PDF). ...
... received dexamethasone. Dexamethasone is a glucocorticoid agent also successfully used for other severe viral infections, such ... Dexamethasone in hospitalized patients with COVID-19. N Engl J Med. 2021;384:693-704. DOIPubMedGoogle Scholar ... Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections On This Page ... Ceftriaxone and dexamethasone were discontinued after 7 days of treatment. On day 13 of admission, headache and neck stiffness ...
Drug Information available for: Dexamethasone Dexamethasone sodium phosphate Dexamethasone acetate Bortezomib Selinexor ... Selinexor, bortezomib, and dexamethasone versus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes ... plus low-dose dexamethasone (SVd) versus bortezomib plus low-dose dexamethasone (Vd) in adult patients with RRMM who have ... and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a randomised, ...
p,Dexamethasone is a corticosteroid with mainly glucocorticoid activity. Oral, parenteral, topical cutaneous, intra-articular ... A decrease of prolactin release after administration of dexamethasone has been observed,sup, (Hubina 2002, Risch 1987),/sup,, ... Dexamethasone Phosphate is also known as Dexamethasone. Here it is a list of alternative known names:: *9α-Fluoro-16α- ... Dexamethasone and adrenocorticotropin suppress prolactin secretion in humans. Endocrine. 2002 Abstract *WHO / UNICEF. ...
Dexamethasone is a corticosteroid used in a wide range of conditions for its anti-inflammatory and immunosuppressant effects. ... A SIGNIFICANT CONTRACT TO SUPPLY A SAFETY NET OF ADDITIONAL DEXAMETHASONE IN CANADA ... which represents five times the total current market demand for dexamethasone. The scale up will continue throughout 2021 and ... company has been awarded a contract with the Government of Canada to supply the Critical Drug Reserve of Dexamethasone tablets ...
dexamethasone acetate: RN given refers to (11beta,16alpha)-isomer ... Subscribe to New Research on dexamethasone acetate RN given ... lidocaine and 0.5 mL of a suspension containing dexamethasone acetate (8 mg mL(-1)) and dexamethasone disodium sulfate (2 mg mL ... 03/01/2000 - "In this group of children a single intramuscular injection of dexamethasone acetate was as effective as a 5-day ... 05/01/2011 - "The aim of this study was to evaluate the effectiveness of 4 mg dexamethasone acetate injection to treat carpal ...
Sample concentration 2.2 - 3.0 g/l solids, where 2.0 g/l excipients (DPPC and HA) solution and 0.1-0.5g DXA in PLGA nanoparticle suspension Solvent Water/Ethanol Carrier, Filmogen PLGA nanoparticles, Dipatmitoyl-phosphatidylcholine (DPPC) and Hyaluronic acid (HA ...
A formulation for preparing Rolapitant Injectable Emulsion with Dexamethasone Sodium Phosphate Admixture. Includes ingredients ... Rolapitant Injectable Emulsion with Dexamethasone Sodium Phosphate Admixture. Allen Loyd V Jr May/Jun 2018. 237. Buy. ... Compatibility and Stability of Rolapitant Injectable Emulsion Admixed with Dexamethasone Sodium Phosphate. Wu George, Yeung ... Abstract: A formulation for preparing Rolapitant Injectable Emulsion with Dexamethasone Sodium Phosphate Admixture. Includes ...
This study provides Class IV evidence that pulsed dexamethasone or 8-month daily prednisolone can lead to long-term remission ... Long-term remission of CIDP after pulsed dexamethasone or short-term prednisolone treatment Neurology. 2012 Apr 3;78(14):1079- ... Cure (,5 years off treatment) or remission according to the CDAS criteria after 1 or 2 courses of pulsed dexamethasone or daily ... Classification of evidence: This study provides Class IV evidence that pulsed dexamethasone or 8-month daily prednisolone can ...
Treatment with dexamethasone after a primary blast injury promoted fast recovery in an in vitro model of the BBB.. Read More ... Dexamethasone, an inexpensive steroid, reduced death by one-third in ventilated COVID-19 patients, and by one fifth in patients ... Preliminary findings suggest one death per eight patients ventilated could be prevented by administering dexamethasone.. Read ...
In [a child with croup] is [low dose oral dexamethasone (0.15 mg/kg or 0.3 mg/kg) as good as 0.6 mg/kg] at [reducing croup ...
Actual Dexamethasone Sodium Phosphate side effects submitted by users. ... Dexamethasone Sodium Phosphate What is Dexamethasone Sodium Phosphate used for in cancer treatments? Agp1124- over a year ago ... Dexamethasone Sodium Phosphate Side Effects. Dexamethasone Sodium Phosphate Information , Add to my Topics , ... Side effects and experiences with Dexamethasone Sodium Phosphate by users like you. Post Yours Now. ...
... but you should NOT use dexamethasone as a COVID-19 prophylaxis! ... Dexamethasone is said to be the first drug proven to save lives ... Reason #2 : Dexamethasone Has No Effect On SARS-CoV-2. Dexamethasone has no effect on the SARS-CoV-2 virus (which causes the ... Reason #3 : Dexamethasone Has Dangerous Side Effects. Dexamethasone should not be taken unless it is necessary, because it has ... Dexamethasone : What Is It?. Dexamethasone is a corticosteroid drug that was first produced in 1957, and approved for medical ...
Dexamethasone is the latest drug President Trump is taking to manage COVID-19. Heres what you need to know. ... But dexamethasone didnt appear to help those who did not require that level of respiratory support and may have even been ... In most cases, dexamethasone is prescribed for short-term use and doesnt cause severe side effects, although an upset stomach ... But dexamethasone can be helpful in the treatment of many conditions. And recent research suggests it may also be beneficial ...
Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential ... A combined dexamethasone/corticotropin-releasing hormone test in patients with chronic PTSD--first preliminary results. ... Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential ... "Combined Dexamethasone/corticotropin Releasing Hormone Test Predicts Treatment Response in Major Depression - a Potential ...
The rise of dexamethasone as a lifesaving treatment for critically ill COVID-19 patients is a significant factor driving the ... The Global Dexamethasone Market is expected to grow at a compound annual growth rate of 6.65% in the forecast period of 2021 to ... conditions and increase in the prevalence of diseases will produce lucrative opportunities for the growth of the dexamethasone ... Dexamethasone Market Scope Dexamethasone market is segmented on the basis of countries into the U.S., Canada and Mexico in ...
... lenalidomide and dexamethasone (ISA-KRD) in frontline treatment of high-risk multiple myeloma.. Initially, she explains the ...
Velcade/Revlimid/Dexamethasone New Standard for Newly Diagnosed Multiple Myeloma. Velcade® Revlimid®/Dexamethasone A Bew ... Doxil®, Oncovin®, and Dexamethasone Effective in Recurrent Multiple Myeloma. Doxil®, Oncovin®, Revlimid®, and Dexamethasone ... Further Findings Show Pomalyst plus Low-Dose Dexamethasone Safe and Effective Further Findings Show Pomalyst plus Low-Dose ... The researchers concluded that the treatment combination including Revlimid, Doxil, Oncovin, and dexamethasone appears to ...
The Effect of Preoperative Oral Dexamethasone Supplementation on the Outcome of Thyroidectomised Patients. ... Yes for taking medications that increase the side effect of dexamethasone or enter into drug interactions with dexamethasone: ... No for taking medications that increase the side effect of dexamethasone or enter into drug interactions with dexamethasone: ... Total thyroidectomy, Dexamethasone oral tablet 8mg (Dexamethasone Krka tablets(8mg), Warsaw, Poland)., Placebo oral sweetener ( ...
  • Dexamethasone, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. (medlineplus.gov)
  • Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) indicated for the management of pain and arthritis and dexamethasone is a corticosteroid indicated for a variety of indications including but not limited to arthritis. (safemedicines.org)
  • Dexamethasone is a corticosteroid with mainly glucocorticoid activity. (e-lactancia.org)
  • Dexamethasone is a corticosteroid used in a wide range of conditions for its anti-inflammatory and immunosuppressant effects. (apotex.com)
  • Dexamethasone is a corticosteroid drug that was first produced in 1957, and approved for medical use in 1961. (rojakpot.com)
  • Dexamethasone is a type of a potent anti-inflammatory synthetic adrenal corticosteroid that helps to prevents substances that root inflammation into the body. (databridgemarketresearch.com)
  • This corticosteroid is a water-soluble inorganic ester of dexamethasone which produces a rapid response even when injected intramuscularly. (buyemp.com)
  • patients who are receiving dexamethasone or another corticosteroid for other indications should continue therapy for their underlying conditions as directed by their healthcare providers. (cdc.gov)
  • The steroid dexamethasone has been gaining interest as a treatment for severe COVID-19, with growing evidence that it can reduce mortality in some patients. (cosmosmagazine.com)
  • Dexamethasone, a widely prescribed steroid for inflammatory conditions, affects the expression of fkbp5 in the brain, preventing the formation of the fearful memories that are the hallmark of post traumatic stress disorder. (medindia.net)
  • They found that dexamethasone, a widely prescribed steroid for inflammatory conditions, affects the expression of fkbp5 in the brain, preventing the formation of the fearful memories that are the hallmark of PTSD. (medindia.net)
  • Dexamethasone, an inexpensive steroid, reduced death by one-third in ventilated COVID-19 patients, and by one fifth in patients receiving oxygen for severe coronavirus symptoms. (neurosciencenews.com)
  • The analysis is part of the RECOVERY (Randomised Evaluation of COVid-19 thERapY) trial which was established to test a range of potential therapies for COVID-19, including low-dose dexamethasone -- a steroid treatment. (nationalheraldindia.com)
  • Steroid acne most often affects adolescent or adult patients who have been taking moderate or high doses of oral steroids such as prednisone or dexamethasone for several weeksor months. (centerforautismawareness.com)
  • John's wort is a green, sedating, synthetic, nonsteroidal drug) has been associated with less severe acne lesions than prednisone (Steroid Abcess, US Patent WO 01306839), dexamethasone covid outpatient. (centerforautismawareness.com)
  • In an effort to prevent that atypical sex development, some doctors have offered prenatal dexamethasone, a synthetic steroid, to pregnant women identified through genetic analysis as being at risk of having a child with CAH. (ourbodiesourselves.org)
  • An Oxford trial showed that treatment with the steroid drug dexamethasone cut the risk of death from 40% to 28% for patients on ventilators and from 25% to 20% for patients treated with oxygen. (freethevaccine.org)
  • This phase I/II open-label trial is evaluating the safety and efficacy of venetoclax plus dexamethasone in 51 evaluable patients with t(11;14) relapsed or refractory multiple myeloma. (ascopost.com)
  • Key eligibility criteria for the venetoclax plus dexamethasone cohort in phase I included prior treatment with a proteasome inhibitor and an immunomodulatory drug, and an Eastern Cooperative Oncology Group (ECOG) performance status of up to 1. (ascopost.com)
  • Patients received venetoclax at 800 mg/d plus dexamethasone at 40 mg (20 mg for patients ≥ 75 years of age) on days 1, 8, and 15 of each 21-day cycle. (ascopost.com)
  • "Venetoclax plus dexamethasone combination therapy had an acceptable safety profile in patients with t(11;14) relapsed or refractory disease," Dr. Kaufman said. (ascopost.com)
  • The combination of venetoclax plus dexamethasone is being investigated in the ongoing phase III M13-494 (CANOVA) trial in t(11;14)-positive relapsed or refractory multiple myeloma. (ascopost.com)
  • Metoclopramide plus dexamethasone combination significantly decreased nausea and vomiting both in the recovery room and 24 hours afterwards and is recommended for high-risk groups, especially in outpatient surgeries. (who.int)
  • In an oral presentation, Jeffrey A. Zonder, MD, Division of Hematology-Oncology, Karmanos Cancer Center, Wayne State University School of Medicine,Detroit, Michigan, reported updated results of SWOG 0232, a study of lenalidomide (Revlimid) plus dexamethasone compared with dexamethasone alone in patients with newly diagnosed multiple myeloma (MM). (onclive.com)
  • 002). In addition, patients in the lenalidomide plus dexamethasone arm of the study had a progression-free survival rate of 77% after one year, compared with 55% for dexamethasone alone ( P = .002). (onclive.com)
  • At one year, overall survival for patients in the lenalidomide plus dexamethasone arm was 93%, compared with 91% for dexamethasone alone. (onclive.com)
  • These data were confounded by the fact that patients in the dexamethasone-alone arm were given the option to cross over into the lenalidomide plus dexamethasone- arm after the study was halted early. (onclive.com)
  • Grade 3/4 adverse events were more frequent in patients with MM who received the combination of lenalidomide-plus dexamethasone compared with dexamethasone alone. (onclive.com)
  • Deep vein thrombosis occurred in 27% of patients receiving lenalidomide plus dexamethasone, compared with 14.6% in those receiving dexamethasone alone. (onclive.com)
  • The primary objective was to describe the safety profile of carfilzomib plus dexamethasone regimen in adults with relapse d or refractory multiple myeloma (RRMM) with 1 to 3 prior lines of therapy at study entry. (survivornet.com)
  • Researchers from the George Institute for Global Health have delivered data in a paper in JAMA showing that a higher (12mg) dose of dexamethasone doesn't reduce mortality any better than a 6mg dose, but nor does it have worse side-effects. (cosmosmagazine.com)
  • He found that when given a dose of dexamethasone high enough to enter the brain, the mice almost uniformly extinguished fear. (medindia.net)
  • To further this research, Galatzer-Levy recently launched a pilot project to test whether a single oral dose of dexamethasone given in the emergency room after a traumatic accident or injury decreases the chances of developing PTSD. (medindia.net)
  • in group 2 (GT2), oral dose of dexamethasone 12 mg one hour beforesurgery, and oral dose of 15 mg of meloxicamimmediatelypostoperative oral, at 24, 48 e 72h following surgery. (bvsalud.org)
  • Prof Katja Weisel speaks to ecancer about the updated interim analysis of the GMMG-Concept trial investigating isatuximab, carfilzomib, lenalidomide and dexamethasone (ISA-KRD) in frontline treatment of high-risk multiple myeloma. (ecancer.org)
  • Sagar Lonial, MD, of Winship Cancer Institute, offers his thoughts on abstract 79, "Carfilzomib, Lenalidomide, and Dexamethasone vs Lenalidomide and Dexamethasone in Patients With Relapsed Multiple My. (ascopost.com)
  • Sagar Lonial, MD, of Winship Cancer Institute, offers his thoughts on abstract 302, "Final Results for the 1703 Phase Ib/II Study of Elotuzumab in Combination With Lenalidomide and Dexamethasone in Pa. (ascopost.com)
  • In this prospective cohort study we present long-term follow-up data on patients included in a multicenter randomized controlled trial comparing 6 monthly pulses of dexamethasone with 8 months of daily prednisolone. (nih.gov)
  • Half of the patients who were in remission after initial treatment experienced a relapse (median treatment-free interval: 17.5 months for dexamethasone, 11 months for prednisolone). (nih.gov)
  • Cure or long-term remission can be achieved in about one-quarter of patients with CIDP after 1 or 2 courses of pulsed dexamethasone or 8-month daily prednisolone. (nih.gov)
  • This study provides Class IV evidence that pulsed dexamethasone or 8-month daily prednisolone can lead to long-term remission in CIDP. (nih.gov)
  • Finally, sometimes dogs that are on long-term drugs like prednisolone and dexamethasone (both similar to cortisol) can sometimes show Cushing's-like symptoms if the dose is too high (iatrogenic Cushing's disease). (vethelpdirect.com)
  • Carfilzomib, a proteasome inhibitor, is approved as monotherapy and in combination with dexamethasone or lenalidomide-dexamethasone (Rd) for relapsed or refractory multiple myeloma. (cun.es)
  • Toronto, Ontario, April 15, 2021 - As Canadians remain impacted by the spread of COVID-19, Apotex, Canada's largest pharmaceutical company has been awarded a contract with the Government of Canada to supply the Critical Drug Reserve of Dexamethasone tablets in response to the COVID-19 pandemic. (apotex.com)
  • As dexamethasone is cheap, easily available and indicated for the treatment of COVID-19 patients with critically low oxygen levels, even a small difference in death rates or health outcomes could lead to important clinical and health economic benefits at the population level. (cosmosmagazine.com)
  • If dexamethasone works well in humans, we could potentially use it to prevent fearful memories in soldiers on the battlefield, patients in emergency rooms, or anywhere else where healthcare providers provide treatment within hours of traumatic events. (medindia.net)
  • A treatment like dexamethasone is very appealing because it has very few side-effects and is inexpensive," Galatzer-Levy says. (medindia.net)
  • The survival benefit is clear and large in those patients who are sick enough to require oxygen treatment, so dexamethasone should now become standard of care in these patients. (rojakpot.com)
  • But dexamethasone can be helpful in the treatment of many conditions. (self.com)
  • Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker? (unboundmedicine.com)
  • The rise of dexamethasone as a lifesaving treatment for critically ill COVID-19 patients is a significant factor driving the market growth rate. (databridgemarketresearch.com)
  • According to an article recently published in Annals of Oncology , the treatment combination consisting of Revlimid® (lenalidomide), Oncovin® (vincristine), Doxil® (pegylated doxorubicin), and dexamethasone appears highly effective in multiple myeloma that has recurred or progressed following prior therapies. (cancerconnect.com)
  • Researchers from the Cleveland Clinic recently conducted a clinical trial to evaluate the combination of Doxil, Oncovin, Revlimid, and dexamethasone in the treatment of patients with recurrent or refractory multiple myeloma. (cancerconnect.com)
  • The researchers concluded that the treatment combination including Revlimid, Doxil, Oncovin, and dexamethasone appears to provide high anticancer activity in recurrent or refractory multiple myeloma. (cancerconnect.com)
  • Cyclophosphamide, Bortezomib, and Dexamethasone (CYBOR-D) chemotherapy is commonly used for the treatment of multiple myeloma and has not been noted in guidelines to be causative in HBV reactivation. (hindawi.com)
  • This study aimed to investigate the role of therapeutic dexamethasone (Dex) treatment on the mechanisms underlying chemokine expression during mild and severe acute pancreatitis (AP) experimentally induced in rats. (uva.es)
  • Treatment of L6 myotubes with dexamethasone resulted in increased cellular levels of acetylated C/EBPbeta and delta, FOXO1 and 3a, and p65. (mcw.edu)
  • Ask your doctor when you can safely receive a live vaccine after your dexamethasone treatment ends. (health32.com)
  • or Darzalex, Revlimid, and dexamethasone can work well for people who have tried one to three treatment plans in the past. (webmd.com)
  • If you've tried two or more treatment plans in the past, your doctor may suggest the drug combo of Darzalex, pomalidomide (Pomalyst), and dexamethasone. (webmd.com)
  • 2014]. This review summarizes treatment options available for DMO, details the main clinical trials of Ozurdex (Allergan, Inc., Irvine, CA) dexamethasone intravitreal implants in DMO, and concludes with our perspective on its place in current management. (docksci.com)
  • treatment was initiated with intravenous ceftriaxone and dexamethasone. (cdc.gov)
  • Tobramycin - dexamethasone eye drops and ointment are combination medications used for the treatment of inflammatory eye conditions for people who have a bacterial eye infection or are at risk of a bacterial eye infection. (pharmachoice.com)
  • The viral load of H1N1 and RSV was significantly elevated in CS/virus-exposed mice and NCI-H292 cells after Fluticasone and Dexamethasone treatment. (uni-wuerzburg.de)
  • Furthermore, the findings from this work indicate that treatment with Fluticasone or Dexamethasone might not be beneficial to reduce inflammation in the airways of COPD patients and supports clinical studies that link treatment with corticosteroids to an increased risk for pneumonia. (uni-wuerzburg.de)
  • All the articles whose abstracts were not available were excluded.Results: Dexamethasone use has evolved over the years to include fertility treatment in both males and females in addition to its use in pregnancy to prevent respiratory distress syndrome in neonates despite its side effects due to the fact that its benefits outweigh the risks. (bvsalud.org)
  • Conclusions: Dexamethasone use has evolved over the years to include fertility treatment in addition to use in the prevention of respiratory distress syndrome. (bvsalud.org)
  • We report 2 patients, 1 who had severe Lassa fever complicated by COVID-19 and acute kidney injury (patient A), and 1 who had acute kidney injury and neurologic complications (patient B) who, in addition to intravenous ribavirin and supportive care, received dexamethasone. (cdc.gov)
  • A total of 2104 patients were randomised to receive dexamethasone 6 mg once per day (either by mouth or by intravenous injection) for ten days and were compared with 4321 patients randomised to usual care alone. (rojakpot.com)
  • In some previous studies, preoperative intravenous dexamethasone supplementation was associated with a reduced incidence of postoperative laryngeal nerve palsy, postoperative hypoparathyroidism, and with less severe postoperative pain, postoperative sore throat, nausea and vomiting. (centerwatch.com)
  • This double-blind clinical trial assessed the incidence of nausea and vomiting after cataract surgery with intravenous anaesthesia in 100 patients randomly assigned to preinduction placebo (saline), metoclopramide (10 mg), dexamethasone (8 mg) or the 2 drugs combined. (who.int)
  • Genetics of pleiotropic effects of dexamethasone. (cdc.gov)
  • As well as the proven efficacy of intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents, phase II and III clinical trials of Ozurdex intravitreal dexamethasone implants for DMO have also demonstrated a mean increase in visual acuity and corresponding mean reduction in central macular thickness, particularly in pseudophakic eyes. (docksci.com)
  • Pretreatment with TLR3 agonist poly(I:C) and TLR2 agonist BCG primarily activated Kupffer cells, inhibiting the sporozoite development into the exoerythrocytic form, whereas Kupffer cell antagonists dexamethasone and cyclophosphamide promoted development of the liver stage. (nih.gov)
  • This Phase 3, 2-arm, randomized, active comparator-controlled, open-label, multicenter study will compare the efficacy and health-related quality of life (HR-QoL) and assess the safety of selinexor plus bortezomib (Velcade) plus low-dose dexamethasone (SVd) versus bortezomib plus low-dose dexamethasone (Vd) in adult patients with RRMM who have received 1 to 3 prior anti-multiple myeloma (MM) regimens. (clinicaltrials.gov)
  • Phase III Study in Patients with Relapsed/Refractory Multiple Myeloma to compare the efficacy of plitidepsin in combination with dexamethasone vs. dexamethasone alone measured by progression-free survival (PFS) and to evaluate tumor response, duration of response (DR), overall survival (OS) and to rule out any effect of plitidepsin on the duration of the QT/QTc interval (time corresponding to the beginning of depolarization to re-polarization of the ventricles). (clinicaltrials.gov)
  • To compare the efficacy of plitidepsin in combination with dexamethasone vs. dexamethasone alone as measured by progression-free survival (PFS) in patients with relapsed/refractory multiple myeloma (MM). (clinicaltrials.gov)
  • The presence of diclofenac and dexamethasone in Artri King Reforzado con Ortiga y Omega 3 renders it an unapproved drug for which the safety and efficacy has not been established and, therefore, subject to recall. (safemedicines.org)
  • Dexamethasone is a glucocorticoid agent also successfully used for other severe viral infections, such as COVID-19, to reduce damage conferred by systemic hyperinflammation ( 13 ). (cdc.gov)
  • Loss of GR in the bronchial epithelium was associated with a loss of rhythmic neutrophil influx after challenge, but anti-inflammatory sensitivity to the synthetic glucocorticoid dexamethasone remained. (bl.uk)
  • On the basis application, the dexamethasone market is segmented into anti-inflammatory and immunosuppressant effects, respiratory distress syndrome, COVID-19 and others. (databridgemarketresearch.com)
  • The retention of anti-inflammatory dexamethasone sensitivity suggests a role for cross-talk between the bronchial epithelium and additional cell populations, consistent with recent evidence for immuno-suppressive macrophage-epithelium communication in the lung. (bl.uk)
  • Side effects and experiences with Dexamethasone Sodium Phosphate by users like you. (medications.com)
  • What is Dexamethasone Sodium Phosphate used for in cancer treatments? (medications.com)
  • Dexamethasone Sodium Phosphate Injection, USP is a clear, colorless liquid. (buyemp.com)
  • Study of Plitidepsin in combination with dexamethasone versus dexamethasone alone in patients with relapsed/refractory multiple myeloma. (clinicaltrials.gov)
  • Determine the response rate of patients with recurrent or refractory stage II or III multiple myeloma treated with arsenic trioxide and dexamethasone. (knowcancer.com)
  • Dexamethasone is in a class of drugs called steroids. (health32.com)
  • To further determine if manipulating fkbp5 could prevent the abnormal paths of extinction learning, Galatzer-Levy looked at data taken from a mouse study in which they were fear conditioned, given doses of dexamethasone or a placebo, and then put through fear extinction training the following day. (medindia.net)
  • Patients who responded could receive maintenance therapy: 21-day cycles of bortezomib (days 1, 8), lenalidomide (days 1-14), and dexamethasone (days 1, 2, 8, 9), all at doses tolerated at end of cycle 8. (empr.com)
  • CHICAGO - Dexamethasone/povidone-iodine ophthalmic suspension (SHP640) effectively treated viral conjunctivitis in a randomized controlled phase 2 trial, researchers reported at Academy 2017 , the American Academy of Optometry (AAOpt) Annual Conference. (medscape.com)
  • Based on 32 patients who remained alive at data cutoff, overall survival (OS) results are also encouraging, noted Paul G. Richardson, MD, of the Dana-Farber Cancer Institute, Boston, Mass. A previous phase 1/2 study demonstrated that as front-line therapy, the combination of lenalidomide 25 mg, bortezomib 1.3 mg/m 2 , and dexamethasone 20/10 mg generated high response rates (Richardson et al. (empr.com)
  • Bendamustine, thalidomide and dexamethasone combination therapy for relapsed/refractory myeloma patients: results of the MUKone randomized dose selection trial. (themmrf.org)
  • The Global Dexamethasone Market is expected to grow at a compound annual growth rate of 6.65% in the forecast period of 2021 to 2028 and likely to reach USD 4,634.01 million by 2028. (databridgemarketresearch.com)
  • Also the increase in the incidences of viral disease outbreak and rise in awareness concerning use of dexamethasone are also expected to fuel the demand of the dexamethasone market over the forecast period of 2021 to 2028. (databridgemarketresearch.com)
  • In a phase I/II study of patients with advanced multiple myeloma and t(11;14) translocations, the combination of venetoclax and dexamethasone showed strong, durable activity, even in patients refractory to daratumumab, study investigators reported at the 2019 American Society of Hematology (ASH) Annual Meeting & Exposition. (ascopost.com)
  • Dexamethasone also showed some promise in helping those who received oxygen, but not as much as those who needed mechanical ventilation. (self.com)
  • They found that dexamethasone reduced deaths by one-third in ventilated patients, and by one fifth in other patients receiving oxygen only. (nationalheraldindia.com)
  • Dexamethasone comes as a tablet and a solution to take by mouth. (medlineplus.gov)
  • dexamethasone: 4 mg tablet. (clinicaltrials.gov)
  • The formulation type segment of dexamethasone market is segmented into liquid, tablet, solution for injection and other. (databridgemarketresearch.com)
  • Why doing lipid profile test in patient taken isotretinoin tablet or dexamethasone tablet? (healthtap.com)
  • The incidence of nausea in the recovery room was 44% with placebo, 20% with metoclopramide, 16% with dexamethasone and 8% with the combination. (who.int)
  • However, both the Japanese and international guidelines recommend a three-drug combination of a neurokinin 1 receptor antagonist (NK1RA), a 5HT3RA, and dexamethasone for patients receiving carboplatin, which is classified as MEC. (researchsquare.com)
  • Cette étude clinique en double aveugle évaluait l'incidence des nausées et des vomissements après une chirurgie de la cataracte avec anesthésie par voie intraveineuse chez 100 patients auxquels un placebo (eau saline), du métoclopramide (10 mg), de la dexaméthasone (8 mg) ou les deux médicaments associés avaient été administrés de manière randomisée avant l'opération. (who.int)
  • L'incidence des nausées en salle de réveil était de 44 % avec le placebo, 20 % avec le métoclopramide, 16 % avec la dexaméthasone et 8 % avec l'association des deux médicaments. (who.int)
  • Whereas, the certain side effects coupled with use of dexamethasone and rise in preventive measures like vaccines under development are expected to hinder the growth of the dexamethasone market in the aforementioned forecast period. (databridgemarketresearch.com)
  • Clinically relevant treatments such as the corticosteroids Fluticasone propionate and Dexamethasone, the phosphodiesterase-4 (PDE-4) inhibitor Roflumilast and the long-acting muscarinic receptor antagonist Tiotropium were tested in the established models. (uni-wuerzburg.de)
  • After 28 days, about 23% of those in the dexamethasone group (482 patients) had died compared to 26% of those in the control group (1,110 patients), which suggests the medication may have provided a small benefit. (self.com)
  • Online pharmacy with discount prices on prescription drugs and medication without prior prescription medrol dexamethasone ivf . (hauptstadtlabor.berlin)
  • Dexamethasone may also be used for other purposes not listed in this medication guide. (health32.com)
  • You should not use this medication if you are allergic to dexamethasone or sulfites, or if you have a fungal infection anywhere in your body. (health32.com)
  • After being informed of the outcome of the competitive process, Apotex significantly ramped up production to manufacture the supply, which represents five times the total current market demand for dexamethasone. (apotex.com)
  • If you have mild to moderate COVID-19 symptoms - not requiring respiratory assistance - then dexamethasone cannot help improve your outcome. (rojakpot.com)
  • The Effect of Preoperative Oral Dexamethasone Supplementation on the Outcome of Thyroidectomised Patients. (centerwatch.com)
  • The aim of the study is to evaluate the clinical impact of preoperative oral dexamethasone supplementation on the surgical outcome in patients with multinodular goiter undergoing total thyroidectomy. (centerwatch.com)
  • Dexamethasone, topical use (ophthalmic, dermatological) ( Safe. (e-lactancia.org)
  • Each gram of sterile ophthalmic ointment contains tobramycin 3 mg and dexamethasone 0.1% with chlorobutanol 0.5% as a preservative in a mineral oil and petrolatum base. (pharmachoice.com)
  • Do NOT Use Dexamethasone As COVID-19 Prophylaxis! (rojakpot.com)
  • However, you should NOT use dexamethasone as a COVID-19 prophylaxis - taking it to prevent being infected! (rojakpot.com)
  • As important as these findings are, it is extremely important that we should NOT use dexamethasone as a COVID-19 prophylaxis. (rojakpot.com)
  • Exaggerated corticotropin (ACTH) and cortisol response to the combined dexamethasone (DEX)/corticotropin releasing hormone (CRH) test, indicating impaired regulation of the hypothalamus-pituitary-adrenocortical (HPA) system, is frequently observed in depression. (unboundmedicine.com)
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  • tell your doctor and pharmacist if you are allergic to dexamethasone, aspirin, tartrazine (a yellow dye in some processed foods and drugs), or any other drugs. (medlineplus.gov)
  • Whilst the data do not provide unequivocal evidence that dexamethasone 12mg is better than 6mg, we saw a trend towards reduced requirement for life support and mortality at the higher dose without any increase in risk of serious infections," adds co-author Professor Vivek Jha, from the George Institute India. (cosmosmagazine.com)
  • Dexamethasone is an immunosuppressant , which means it will suppress your body's immune system, and make you more susceptible to infections. (rojakpot.com)
  • The purpose of this review was to provide an overview of the uses of dexamethasone and its impacts on pregnancy and fertility in humans. (bvsalud.org)
  • Oral dexamethasone therapy was initiated, and the patient was referred to domestic quarantine, according to standard local practice. (cdc.gov)
  • IMSEAR at SEARO: Dexamethasone therapy in chronic ITP. (who.int)
  • Each mL of sterile, isotonic, aqueous suspension contains tobramycin 3 mg and dexamethasone 0.1% with benzalkonium chloride 0.01% as a preservative. (pharmachoice.com)
  • In most cases, dexamethasone is prescribed for short-term use and doesn't cause severe side effects, although an upset stomach is common, MedlinePlus says. (self.com)
  • Consumption of undeclared dexamethasone may lead to severe and serious adverse events such as adrenal suppression, a disorder in which the adrenal glands do not produce enough hormones, and adverse consequences can range from limited adverse consequences to death. (safemedicines.org)
  • Dexamethasone suppression was evident. (cdc.gov)
  • The dexamethasone suppression test for melancholia. (bvsalud.org)
  • But dexamethasone didn't appear to help those who did not require that level of respiratory support and may have even been detrimental to their care, the authors write. (self.com)
  • However, the researchers said there was no benefit from dexamethasone among the patients who did not require respiratory support. (nationalheraldindia.com)