A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
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An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
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A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
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An enzyme that catalyzes the conversion of L-TYROSINE and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-GLUTAMATE. It is a pyridoxal-phosphate protein. L-PHENYLALANINE is hydroxylated to L-tyrosine. The mitochondrial enzyme may be identical with ASPARTATE AMINOTRANSFERASES (EC 184.108.40.206.). Deficiency of this enzyme may cause type II Tyrosinemia (see TYROSINEMIAS). EC 220.127.116.11.
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A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
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Specific receptors for glucocorticoid in the cytoplasm of the liver of AH 130 tumor-bearing rats. (1/8350)Specific receptors for dexamethasone (11beta, 17alpha, 21-trihydroxy-9alpha-fluoro-16alpha-methyl-1,4-pregnadiene-3,20-dione) in the cytoplasm of the liver from AH 130 (solid type) tumor-bearing rats markedly increased in the advanced stage of tumor growth. The cytoplasmic receptors of the livers of normal and tumor-bearing rats differed in their affinities for dexamethasone, and their apparent equilibrium (dissociation) constants (K) for dexamethasone were 4.0 and 2.6 X 10(-9) M, respectively. The rates of dissociation of dexamethasone-receptor complexes and the heat denaturations of the receptors in the livers of normal and tumor-bearing rats were similar. The glucocorticoid receptors of tumor-bearing rat liver had slightly higher affinities than did those of normal liver for all the steroids tested. Only a trace amount of receptors for dexamethasone could be detected in the cytoplasm of AH 130 ascites cells. (+info)
The effects of glucocorticoids and progesterone on hormone-responsive human breast cancer in long-term tissue culture. (2/8350)Glucocorticoids, at physiological concentration, inhibit cell division and thymidine incorporation in three lines of human breast cancer maintained in long-term tissue culture. At steroid concentrations sufficient to inhibit thymidine incorporation 50%, little or no effect is seen on protein synthesis 48 hr after hormone addition. All three of these lines are shown to have glucocorticoid receptors demonstrable by competitive protein binding assays. Receptors are extensively characterized in one line by sucrose density gradient analysis and binding specificity studies. Good correlation between receptor-binding specificity and biological activity is found except for progesterone, which binds to glucocorticoid receptor but is noninhibitory. Cross-competition and quantification studies demonstrate a separate receptor for progesterone. This receptor has limited binding specificities restricted largely to progestational agents, whereas the glucocorticoid receptor bound both glucocorticoids and progesterone. Two other human breast cancer lines neither contain glucocorticoid receptor nor are inhibited by glucocorticoids. It is concluded that in some cases glucocorticoids can directly limit growth in human breast cancer in vitro without requiring alterations in other trophic hormones. (+info)
Effect of hepatocarcinogens on the binding of glucocorticoid-receptor complex in rat liver nuclei. (3/8350)The effects of a number of carcinogens and hepatotoxins on the binding kinetics of the interactions of glucocorticoidcytosol receptor complex with nuclear acceptor sites in rat liver were investigated. Both the apparent sites in rat liver were investigated. Both the apparent concentration of nuclear binding sites and the Kd were significantly diminished following treatment of rats with sublethal doses of the carcinogens aflatoxin B1, diethylnitrosamine, dimethylnitrosamine, thioacetamide, 3'-methyl-4-dimethylaminoazobenzene, 4-dimethylaminoazobenzene, and 3-methylcholanthrene. Treatment with actinomycin D resulted in a slight reduction in the apparent concentration of nuclear acceptor sites but had no effect on the nuclear binding Kd. The hepatotoxic but noncarcinogenic analgesic, acetaminophen, as well as the weakly toxic aflatoxin B1 cognate, aflatoxin B2, were without effect on the kinetics or binding capacity of glucocorticoid-nuclear acceptor site interaction. These experiments suggest that chemically induced alteration of functional glucocorticoid binding sites on chromatin may be involved in the biochemical effects produced in liver by carcinogens of several chemical types. This experimental model may provide a useful approach for further elucidation of early events in carcinogenesis. (+info)
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. (4/8350)BACKGROUND: The Jun N-terminal kinase (JNK) signaling pathway has been implicated in cell proliferation and apoptosis, but its function seems to depend on the cell type and inducing signal. In T cells, JNK has been implicated in both antigen-induced activation and apoptosis. RESULTS: We generated mice lacking the JNK2 isozymes. The mutant mice were healthy and fertile but defective in peripheral T-cell activation induced by antibody to the CD3 component of the T-cell receptor (TCR) complex - proliferation and production of interleukin-2 (IL-2), IL-4 and interferon-gamma (IFN-gamma) were reduced. The proliferation defect was restored by exogenous IL-2. B-cell activation was normal in the absence of JNK2. Activation-induced peripheral T-cell apoptosis was comparable between mutant and wild-type mice, but immature (CD4(+) CD8(+)) thymocytes lacking JNK2 were resistant to apoptosis induced by administration of anti-CD3 antibody in vivo. The lack of JNK2 also resulted in partial resistance of thymocytes to anti-CD3 antibody in vitro, but had little or no effect on apoptosis induced by anti-Fas antibody, dexamethasone or ultraviolet-C (UVC) radiation. CONCLUSIONS: JNK2 is essential for efficient activation of peripheral T cells but not B cells. Peripheral T-cell activation is probably required indirectly for induction of thymocyte apoptosis resulting from administration of anti-CD3 antibody in vivo. JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptosis induced by anti-Fas antibody, UVC or dexamethasone. JNK2 is not required for activation-induced cell death of mature T cells. (+info)
Identification of a cAMP response element within the glucose- 6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells. (5/8350)The expression of a luciferase reporter gene under the control of the human glucose 6-phosphatase gene promoter was stimulated by both dexamethasone and dibutyryl cAMP in H4IIE hepatoma cells. A cis-active element located between nucleotides -161 and -152 in the glucose 6-phosphatase gene promoter was identified and found to be necessary for both basal reporter-gene expression and induction of expression by both dibutyryl cAMP and dexamethasone. Nucleotides -161 to -152 were functionally replaced by the consensus sequence for a cAMP response element. An antibody against the cAMP response element-binding protein caused a supershift in gel-electrophoretic-mobility-shift assays using an oligonucleotide probe representing the glucose 6-phosphatase gene promoter from nucleotides -161 to -152. These results strongly indicate that in H4IIE cells the glucose 6-phosphatase gene-promoter sequence from -161 to -152 is a cAMP response element which is important for the regulation of transcription of the glucose 6-phosphatase gene by both cAMP and glucocorticoids. (+info)
Production of prostaglandin f2alpha and its metabolite by endometrium and yolk sac placenta in late gestation in the tammar wallaby, Macropus Eugenii. (6/8350)In this study, we investigated production of prostaglandin (PG) F2alpha and its metabolite, PGFM, by uterine tissues from tammar wallabies in late pregnancy. Endometrial explants were prepared from gravid and nongravid uteri of tammars between Day 18 of gestation (primitive streak) and Day 26.5 (term) and were incubated in Ham's F-10 medium supplemented with glutamine and antibiotics for 20 h. PGF2alpha and PGFM in the medium were assayed by specific, validated RIAs. Control tissues (leg muscle) did not produce detectable amounts of either PG. Both gravid and nongravid endometria secreted PGF2alpha, and production increased significantly in both gravid and nongravid uteri towards term. PGFM was produced in small amounts by both gravid and nongravid uteri, and the rate of production did not increase. Neither oxytocin nor dexamethasone stimulated PG production in vitro in any tissue at any stage. Thus, the surge in peripheral plasma PGFM levels seen at parturition may arise from increased uterine PG production, but further study is needed to define what triggers this release. (+info)
Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells. (7/8350)Glucocorticoid hormones, which are physiological regulators of mammary epithelium development, induce the formation of tight junctions in rat Con8 mammary epithelial tumor cells. We have discovered that, as part of this process, the synthetic glucocorticoid dexamethasone strongly and reversibly down-regulated the expression of fascin, an actin-bundling protein that also interacts with the adherens junction component beta-catenin. Ectopic constitutive expression of full-length mouse fascin containing a Myc epitope tag (Myc-fascin) in Con8 cells inhibited the dexamethasone stimulation of transepithelial electrical resistance, disrupted the induced localization of the tight junction protein occludin and the adherens junction protein beta-catenin to the cell periphery, and prevented the rearrangement of the actin cytoskeleton. Ectopic expression of either the carboxyl-terminal 213 amino acids of fascin, which includes the actin and beta-catenin-binding sites, or the amino-terminal 313 amino acids of fascin failed to disrupt the glucocorticoid induction of tight junction formation. Mammary tumor cells expressing the full-length Myc-fascin remained generally glucocorticoid responsive and displayed no changes in the levels or protein-protein interactions of junctional proteins or the amount of cytoskeletal associated actin filaments. However, a cell aggregation assay demonstrated that the expression of Myc-fascin abrogated the dexamethasone induction of cell-cell adhesion. Our results implicate the down-regulation of fascin as a key intermediate step that directly links glucocorticoid receptor signaling to the coordinate control of junctional complex formation and cell-cell interactions in mammary tumor epithelial cells. (+info)
Role of dexamethasone dosage in combination with 5-HT3 antagonists for prophylaxis of acute chemotherapy-induced nausea and vomiting. (8/8350)Dexamethasone (20 mg) or its equivalent in combination with 5-HT3 antagonists appears to be the gold-standard dose for antiemetic prophylaxis. Additional to concerns about the use of corticosteroids with respect to enhanced tumour growth or impaired killing of the tumour cells, there is evidence that high-dosage dexamethasone impairs the control of delayed nausea and emesis, whereas lower doses appear more beneficial. To come closer to the most adequate dose, we started a prospective, single-blind, randomized trial investigating additional dosage of 8 or 20 mg dexamethasone to tropisetron (Navoban), a 5-HT3 receptor antagonist, in cis-platinum-containing chemotherapy. After an interim analysis of 121 courses of chemotherapy in 69 patients, we have been unable to detect major differences between both treatment alternatives. High-dose dexamethasone (20 mg) had no advantage over medium-dose dexamethasone with respect to objective and subjective parameters of acute and delayed nausea and vomiting. In relation to concerns about the use of corticosteroids in non-haematological cancer chemotherapy, we suggest that 8 mg or its equivalent should be used in combination with 5-HT3 antagonists until further research proves otherwise. (+info)
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Adjuvant treatment with dexamethasone plus anti-C5 antibodies improves outcome of experimental pneumococcal meningitis: a...
Background We compared adjunctive treatment with placebo, dexamethasone, anti-C5 antibodies, and the combination of dexamethasone plus anti-C5 antibodies in experimental pneumococcal meningitis. Methods In this prospective, investigator-blinded, randomized trial, 96 mice were infected intracisternally with 107 CFU/ml Streptococcus pneumoniae serotype 3, treated with intraperitoneal ceftriaxone at 20 h, and randomly assigned to intraperitoneal adjunctive treatment with placebo (saline), dexamethasone, anti-C5 antibodies, or dexamethasone plus anti-C5 antibodies. The primary outcome was survival during a 72-h observational period that was analyzed with the log-rank test. Secondary outcome was clinical severity, scored on a validated scale using a linear mixed model. Results Mortality rates were 16 of 16 mice (100 %) in the placebo group, 12 of 15 mice (80 %) in the dexamethasone group, 25 of 31 mice (80 %) in the anti-C5 antibody group, and 18 of 30 mice (60 %) in the dexamethasone plus anti-C5 ...
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Cultured skin fibroblasts from patients with cystic fibrosis (CF) are more resistant to dexamethasone toxicity than are normal cells. We now report that, when fibroblasts cultured from obligate CF heterozygotes are exposed to dexamethasone, they have an intermediate survival compared to normal and homozygous CF cells. When dexamethasone survival was tested on cells from four patients undergoing amniocentesis, cells from a woman at risk of producing a child with CF showed significant dexamethasone resistance, similar to that of fibroblasts derived from lnown CF homozygotes; the other amniotic cell specimens showed dexamethasone sensitivity similar to that of normal skin fibroblasts. These data suggest that the dexamethasone resistance previously observed in skin fibroblasts may also be useful in the prenatal diagnosis of CF. ...
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Therefore, taking dexamethasone should reduce ACTH level and lead to a decreased cortisol level. The diagnosis of Cushings syndrome: An Endocrine Society Clinical Practice Guideline. Healthline Media does not provide medical advice, diagnosis, or treatment. 2. You can get abnormal results mainly due to a tumor in your pituitary gland that produces ACTH, adrenal tumor that releases cortisol, or tumor in the body that leads to the excessive production of ACTH.In this situation, you will have to go for the high-dose test if you havent already done it. Give dexamethasone over 48 hours in doses of 0.5 mg, beginning at 9 AM on day one, at six-hour intervals for a total of eight doses. Procedure: High dose dexamethasone suppression test. An ACTH blood test may tell more about certain causes of high cortisol levels.Even if you have Cushing syndrome, you may get different results depending on the condition thats causing the problem.Even when your test gives abnormalresult, your doctor may still order ...
Diabetics Given Dexamethasone for ENT Surgery At Risk for Postoperative Hyperglycemia | Anesthesia Experts
Although dexamethasone may be a beneficial adjunct to surgery in terms of its antiemetic and anti-inflammatory effects, a team of researchers from Thomas Jefferson University Hospital has found that it may have a darker side, particularly in diabetic patients.. A pilot study concluded that dexamethasone administration was associated with significant postoperative hyperglycemia in these patients when undergoing functional endoscopic sinus surgery (FESS), which ultimately may lead to poorer outcomes.. Dexamethasone is routinely requested by our ENT [ear, nose and throat] surgeons, said Adam Setren, MD, a resident at Thomas Jefferson University Hospital, in Philadelphia. From the anesthesia literature, we know it is a key component in the prevention of nausea and vomiting. From a surgical perspective, theres a commonly held conception-and some evidence to suggest-that it improves operating conditions, decreases inflammation, and may be associated with decreased bleeding and operative times, ...
Effect of dexamethasone on osteoclast formation in the alveolar bone of rabbits
This study was planned to determine whether a short period dexamethasone treatment induce alveolar bone loss or not, therefore, twenty six male albino rabbits were divided into three groups as follow: Test groups I (10 rabbits) received 1.56 mg/kg dexamethasone intraperitoneal injection daily for two weeks, test group II (10 rabbits) received 3.12 mg/kg dexamethasone intraperitoneal injection daily, and the control group (6 rabbits) received saline solution for same period. The animals were sacrificed and histological sections were prepared from the alveolar bone of molar areas of mandible, as well as morphometric analysis of osteoclasts number was performed. The results showed a significant increase in the number of osteoclasts, which indicates that bone loss, is quite inevitable secondary to dexamethasone treatment even in a short period of treatment for two weeks.
MEDIKI • Dexamethasone May Make Immune Checkpoint Inhibitors Less Effective for Glioblastoma
Among patients with glioblastoma receiving an immune checkpoint inhibitor, those who received the corticosteroid dexamethasone at baseline for cerebral edema…
Dexamethasone Regimens Alter Spatial Memory and Anxiety Levels in Mice
Acute and sub chronic effects of oral dexamethasone on anxiety and memory in mice were evaluated using the elevated plus maze, Y maze and radial arm maze. Adult male Swiss albino mice assigned to five groups were given vehicle (normal saline), a standard drug (Diazepam or Scopolamine) or one of three selected doses of dexamethasone (0.5, 1.0 and 1.5 mg/kg) daily for a period of 14 days. Behavioral tests were carried out on days 1 and 14 after administration. Results were analysed using a one-way ANOVA followed by a posthoc test (Student-Newman-Keul) and expressed as mean ± S.E.M. Elevated plus maze test showed a significant reduction in the time spent in the open arm and in the number of open arm entries compared to control. Results of radial arm and Y maze tasks showed an improvement in spatial memory following dexamethasone administration. Y maze locomotor activity was significantly increased, although radial arm maze exploration did not increase significantly. The study concluded that oral
Determining the Long-Term Effects of Prenatal Dexamethasone Treatment in Children With 21-Hydroxylase Deficiency and Their...
CAH is a genetic steroidogenesis disorder. The most common form, 21OHD, leads to cortisol deficiency and, in turn, an excess of androgen, a hormone that promotes the development and maintenance of male sex characteristics. As a result of this androgen excess, prepubescent males and newborn, prepubescent, and grown females exhibit mature masculine characteristics. Prenatal treatment with dexamethasone, a corticosteroid that decreases androgen levels, has been shown to prevent the development of abnormal genitalia in female infants. The long-term effects of this treatment, however, have not been evaluated. This study will determine whether prenatal dexamethasone treatment causes any long-term side effects by examining children and young adults who received dexamethasone as fetuses and their mothers, who were exposed to dexamethasone while pregnant.. This study has three parts. In Part 1 of the study, participants will provide written consent for release of their medical records from their ...
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Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in...
The objective of this study was to evaluate the efficacy of intravenous (i.v.) injection of liposomally encapsulated dexamethasone phosphate (DxM-P) in comparison to free DxM-P in rats with established adjuvant arthritis (AA). This study focused on polyethylene glycol (PEG)-free liposomes, to minimize known allergic reactions caused by neutral PEG-modified (PEG-ylated) liposomes. Efficacy was assessed clinically and histologically using standard scores. Non-specific and specific immune parameters were monitored. Activation of peritoneal macrophages was analyzed via cytokine profiling. Pharmacokinetics/biodistribution of DxM in plasma, synovial membrane, spleen and liver were assessed via mass spectrometry. Liposomal DxM-P (3 × 1 mg/kg body weight; administered intravenously (i.v.) on Days 14, 15 and 16 of AA) suppressed established AA, including histological signs, erythrocyte sedimentation rate, white blood cell count, circulating anti-mycobacterial IgG, and production of interleukin-1beta (IL-1β)
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Dexamethasone Sodium Phosphate Eye Solution for Cats and Dogs
Dexamethasone Sterile Eye Drops are used in the eye to stop inflammation. They are most commonly used to treat conjunctivitis, episcleritis, scleritis, pannus (chronic superficial keratitis), and eosinophilic keratitis of the cat.
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Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in...
We present a pooled update of two large, multicenter MM-009 and MM-010 placebo-controlled randomized phase III trials that included 704 patients and assessed lenalidomide plus dexamethasone versus dexamethasone plus placebo in patients with relapsed/refractory multiple myeloma (MM). Patients in both studies were randomized to receive 25 mg daily oral lenalidomide or identical placebo, plus 40 mg oral dexamethasone. In this pooled analysis, using data up to unblinding (June 2005 for MM-009 and August 2005 for MM-010), treatment with lenalidomide plus dexamethasone significantly improved overall response (60.6 vs 21.9%, P|0.001), complete response rate (15.0 vs 2.0%, P|0.001), time to progression (median of 13.4 vs 4.6 months, P|0.001) and duration of response (median of 15.8 months vs 7 months, P|0.001) compared with dexamethasone-placebo. At a median follow-up of 48 months for surviving patients, using data up to July 2008, a significant benefit in overall survival (median of 38.0 vs 31.6 months, P=0
Effects of early dexamethasone therapy on pulmonary mechanics and chronic lung disease in very low birth weight infants: A...
TY - JOUR. T1 - Effects of early dexamethasone therapy on pulmonary mechanics and chronic lung disease in very low birth weight infants. T2 - A randomized, controlled trial. AU - Durand, M.. AU - Sardesai, S.. AU - McEvoy, C.. PY - 1995/4/24. Y1 - 1995/4/24. N2 - Objective. To determine the changes in pulmonary mechanics before and during early dexamethasone therapy, and to evaluate the effect of dexamethasone on the duration of mechanical ventilation in very low birth weight (VLBW) ventilator-dependent infants at risk for chronic lung disease (CLD). Methods. A prospective randomized trial was conducted. Forty-three patients (birth weight 600 to 1500 g, gestational age 24 to 32 weeks) who failed to be weaned from the respirator at 7 to 14 days of age were enrolled; 23 infants received a 7-day course of dexamethasone (0.5 mg/kg/day intravenously for 3 days, 0.25 mg/kg/day for 3 days, and 0.1 mg/kg/day for 1 day), and 20 patients were in the control group. At similar mean airway pressure (MAP) and ...
Cushings Syndrome: Diseases and Conditions | Pediatric Oncall
The diagnosis of Cushings syndrome is usually made clinically. However to differentiate between adrenal cause and pituitary cause, tests may be required. The most common screening test to establish increased serum cortisol levels is to do 24 hours urine estimation of free cortisol. Normally, the levels are between 20-70 µg/sqm, however in case of Cushings syndrome, urinary free cortisol is elevated. To find out the cause, your doctor may do blood ACTH levels and high dose dexamethasone suppression test. In case of pituitary tumors, ACTH levels will be elevated. In case of adrenal tumors, ACTH levels will be decreased. High dose dexamethasone tests consists of given high dose dexamethasone 6 hourly for 48 hours and then doing urinary free cortisol on 2nd day. In case of suppression of secretion of cortisol in urine, it suggests a pituitary cause and in case of non suppression, it suggests adrenal cause ...
Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple...
Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple myeloma regardless of prior thalidomide exposure.
A randomized, double-blind, parallel, comparative study to evaluate the efficacy and safety of ramosetron plus dexamethasone...
TY - JOUR. T1 - A randomized, double-blind, parallel, comparative study to evaluate the efficacy and safety of ramosetron plus dexamethasone injection for the prevention of acute chemotherapy-induced nausea and vomiting. AU - Ho, Ching Liang. AU - Su, Wu Chou. AU - Hsieh, Ruey Kuen. AU - Lin, Zhong Zhe. AU - Chao, Tsu Yi. PY - 2009/12/20. Y1 - 2009/12/20. N2 - Objective: To evaluate the efficacy of intravenous ramosetron plus dexamethasone for the prevention of acute chemotherapy-induced nausea and vomiting. Methods: Cancer patients scheduled to receive chemotherapy containing either of the four drugs (cisplatin, doxorubicin, epirubicin or oxaliplatin) were enrolled. They were randomized to receive intravenous ramosetron 0.3 mg plus dexamethasone 20 mg or granisetron 3 mg plus dexamethasone 20 mg 30 min before chemotherapy on day 1. The primary efficacy parameter is complete response rate, which was defined by the proportion of patients without vomiting and no requirement for rescue drugs within ...
Dexamethasone decreases oxycodone consumption following osteotomy of the first metatarsal bone: a randomized controlled trial...
Background:Dexamethasone may improve multimodal pain management following painful orthopedic day surgery procedures, and decrease the need for post-operative opioids. We hypothesized that dexamethasone would reduce the need for oxycodone after surgical correction of hallux valgus.Methods:Sixty patie
Dexamethasone treatment of calves latently infected with bovine herpesvirus 1 leads to activation of the bICP0 early promoter,...
TY - JOUR. T1 - Dexamethasone treatment of calves latently infected with bovine herpesvirus 1 leads to activation of the bICP0 early promoter, in part by the cellular transcription factor C/EBP-alpha. AU - Workman, Aspen. AU - Perez, Sandra. AU - Doster, Alan. AU - Jones, Clinton. PY - 2009. Y1 - 2009. N2 - Sensory neurons within trigeminal ganglia (TG) are the primary site for bovine herpesvirus 1 (BHV-1) latency. During latency, viral gene expression is restricted to the latency-related (LR) gene and the open reading frame ORF-E. We previously constructed an LR mutant virus that expresses LR RNA but not any of the known LR proteins. In contrast to calves latently infected with wild-type (wt) BHV-1 or the LR rescued virus, the LR mutant virus does not reactivate from latency following dexamethasone (DEX) treatment. In this study, we demonstrated that bICP0, but not bICP4, transcripts were consistently detected in TG of calves infected with the LR mutant or LR rescued virus following DEX ...
G252(P) Dexamethasone as an alternative to prednisolone for children with wheeze: A review of the literature | Archives of...
Results We found 11 papers comparing dexamethasone to prednisolone of which 8 were controlled trials, one was a retrospective cohort study and two were meta-analyses. There was significant heterogeneity of dosage and method of administration of dexamethasone, including intramuscular, nebulised and oral routes. We analysed four controlled studies of oral dexamethasone, as this was our preferred route. Details of the four studies can be found in Table 1. All of the studies found that dexamethasone was non-inferior to prednisolone. One study compared a single 0.6mg/kg dose of dexamethasone with 5 days of prednisolone, two studies compared two daily 0.6mg/kg doses of dexamethasone with 5 days of prednisolone and the most recent study compared a single 0.3mg/kg dose of dexamethasone with 3 days of prednisolone. Most of the studies have some limitations which may affect the validity of the results. ...
Ultrasound-enhanced ocular delivery of dexamethasone sodium phosphate: an in vivo study | Journal of Therapeutic Ultrasound |...
The potential advantages of using ultrasound for drug, gene, and protein delivery, using parameters that cause cavitation and streaming effects, have been confirmed in different experimental studies [24, 28, 32]. Cavitation is known as the creation, oscillation, and collapse of gas bubbles due to acoustic waves [33-35]. It is stated to be the main mechanism responsible for promoting drug delivery through the skin [32, 36]. There are two types of cavitation: stable and inertial. Stable cavitation is defined as the uniform pulsation of bubbles over long time intervals , and the oscillation of these bubbles can produce mechanical stresses that may cause cell membrane rupture . In the case of inertial cavitation, collapse of the bubbles causes shock waves and microjets to be generated near the cells, thus producing pits in the cell membranes [38, 39]. The effect of inertial cavitation is greater at lower frequencies because bubbles have more time to grow, which results in a more violent ...
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Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells<...
TY - JOUR. T1 - Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells. AU - Tome, Margaret E.. AU - Jaramillo, Melba C.. AU - Briehl, Margaret M.. PY - 2011/12/1. Y1 - 2011/12/1. N2 - Glucocorticoid-induced apoptosis is exploited clinically for the treatment of hematologic malignancies. Determining the required molecular events for glucocorticoid-induced apoptosis will identify resistance mechanisms and suggest strategies for overcoming resistance. In this study, we found that glucocorticoid treatment of WEHI7.2 murine thymic lymphoma cells increased the steady-state [H 2O 2] and oxidized the intracellular redox environment before cytochrome c release. Removal of glucocorticoids after the H 2O 2 increase resulted in a 30% clonogenicity; treatment with PEG-CAT increased clonogenicity to 65%. Human leukemia cell lines also showed increased H 2O 2 in response to glucocorticoids and attenuated apoptosis after PEG-CAT treatment. WEHI7.2 cells that overexpress ...
Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes. | The Journal...
We examined the direct effects of glucocorticoid treatment on neutrophil survival and function in vitro. Four different glucocorticoids caused a dose-dependent inhibition of apoptosis leading to increased survival of neutrophils. Maximal effects were found with dexamethasone at 10(-6) M, 16.6 +/- 6.2 vs 54.6 +/- 6.9, at 24 h (p , 0.05). Nonglucocorticoid steroids did not modulate apoptosis in neutrophils. Furthermore, the effect was inhibited in a dose-dependent manner by the glucocorticoid antagonist RU 486. Glucocorticoid-treated neutrophils produced significantly more superoxide in response to FMLP than untreated controls (p , 0.05). However, both basal and stimulated superoxide production were less than that found with freshly isolated cells. Such lack of priming or activation by glucocorticoids is in contrast to previous experience when increased survival was accompanied by cell activation. When compared with other stimuli, the effect of glucocorticoids at 24 h was similar to that of LPS ...
Exogenous glucocorticoids and adverse cerebral effects in children - Forskning - Rigshospitalet
Glucocorticoids are commonly used in treatment of paediatric diseases, but evidence of associated adverse cerebral effects is accumulating. The various pharmacokinetic profiles of the exogenous glucocorticoids and the changes in pharmacodynamics during childhood, result in different exposure of nervous tissue to exogenous glucocorticoids. Glucocorticoids activate two types of intracellular receptors, the mineralocorticoid receptor and the glucocorticoid receptor. The two receptors differ in cerebral distribution, affinity and effects. Exogenous glucocorticoids favor activation of the glucocorticoid receptor, which is associated with unfavorable cellular outcomes. Prenatal treatment with glucocorticoids can compromise brain growth and is associated with periventricular leukomalacia, attentions deficits and poorer cognitive performance. In the neonatal period exposure to glucocorticoids reduces neurogenesis and cerebral volume, impairs memory and increases the incidence of cerebral palsy. Cerebral ...
JCI - Ketoconazole binds to glucocorticoid receptors and exhibits glucocorticoid antagonist activity in cultured cells.
We have recently found that ketoconazole inhibits adrenal steroidogenesis; in this paper we investigated whether imidazole antimycotic drugs additionally interact with glucocorticoid receptor sites in target tissues. Our approach was to assess the ability of three drugs: ketoconazole, clotrimazole, and RS 49910, to inhibit [3H]dexamethasone binding to hepatoma tissue culture (HTC) cell cytosol. The results indicated dose-dependent, competitive displacement of [3H]dexamethasone binding that was in the potency sequence: clotrimazole greater than ketoconazole greater than RS 49910. We then examined the functional response of this binding by measuring tyrosine aminotransferase (TAT) activity in HTC cells. The antimycotics did not exhibit TAT agonist activity and inhibition of basal enzyme levels was not detected. However, the drugs were potent antagonists of dexamethasone-induced TAT activity and the effect was temporally reversible. This antagonist activity was in the same sequence and closely ...
Prenatal Dexamethasone Exposure Does Not Alter Blood Pressure and Nephron Number in the Young Adult Marmoset Monkey |...
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CiNii 論文 - Dexamethasone Increases β 2 : Adrenoceptor : Regulated Phosphatidylcholine...
Insufficient production of pulmonary surfactant in alveolar type II cells is relevant to many lung diseases. To cure its deficiency, glucocorticoid is commonly used in clinical areas. In the present study, we investigated the effect of dexamethasone on the secretion of phosphatidylcholine, a major phospholipid of pulmonary surfactant, in a primary culture of rat alveolar type II cells. Dexamethasone had no effect on the basal secretion rate of phosphatidylcholine. Dexamethasone augmented both the phosphatidylcholine secretion and the cyclic AMP formation increased by terbutaline. Furthermore, dexamethasone increased the number of β-adrenoceptors and mRNA expression of β,SUB,2,/SUB,-adrenoceptors in type II cells. These findings indicate that dexamethasone increases pulmonary surfactant secretion through an enhancement of β,SUB,2,/SUB,-adrenoceptor gene expression.. ...
Cushings & Cancer: January 2010
1. High dose dexamethasone testing. For more than 30 yr HDDST has remained one of the main biochemical tools used in the differential diagnosis of ACTH-dependent Cushings syndrome. The basis of the test relies on the fact that, in most situations, the corticotroph tumor cells in Cushings disease retain some responsiveness to the negative feedback effects of glucocorticoids while tumors ectopically secreting ACTH do not. The standard test was performed on 24-h collections of urine for the measurement of 17-OHCS or UFC, calculating the degree of suppression from day 1 to day 3 after the administration of oral dexamethasone at a dose of 2 mg every 6 h for 48 h. As with the LDDST, several suppression cut-offs that optimally define pituitary disease, in addition to combinations of measurements of different steroids, have been reported. Originally, suppression of urinary 17-OHCS by 50% or greater was reported as being consistent with Cushings disease (60). Although this criterion has no intrinsic ...
Trump Given Dexamethasone; Surprise Drive-by Criticized - visualspacecoast.com
President Donald Trumps condition was more serious than originally reported when he went to hospital on Friday evening after testing positive for coronavirus, reports said.. The White House initially said Trump was experiencing mild symptoms of Covid-19, but Trumps chief of staff Mark Meadows told reporters, The Presidents vitals over the last 24 hours were very concerning and the next 48 hours will be critical in terms of his care. We are still not on a clear path to a full recovery, he added.. One of the physicians treating Trump later said that he was treated with the steroid Dexamethasone after oxygen level dropped for two days. White House physician Sean P. Conley then confirmed it.. Dexamethasone is not a drug that is usually given in the mild stage of the disease.. There are reports that the president was doing well and might be discharged from Walter Reed national Military Medical Center in Bethesda, Md, on Monday.. The President has no public events scheduled for Monday, according ...
Depot delivery of dexamethasone and cediranib for the treatment of brain tumor associated edema in an intracranial rat glioma...
Treatments of brain tumor associated edema with systemically delivered dexamethasone, the standard of care, and cediranib, a novel anti-edema agent, are associated with systemic toxicities in brain tumor patients. A tunable, reservoir-based drug delivery device was developed to investigate the effects of delivering dexamethasone and cediranib locally in the brain in an intracranial 9 L gliosarcoma rat model. Reproducible, sustained releases of both dexamethasone and solid dispersion of cediranib in polyvinylpyrrolidone (AZD/PVP) from these devices were achieved. The water-soluble AZD/PVP, which exhibited similar bioactivity as cediranib, was developed to enhance the release of cediranib from the device. Local and systemic administration of both dexamethasone and cediranib was equally efficacious in alleviating edema but had no effect on tumor growth. Edema reduction led to modest but significant improvement in survival. Local delivery of dexamethasone prevented dexamethasone-induced weight loss, ...
Effect of steroids and nonsteroidal antiinflammatory agents on human ocular fibroblast. | IOVS | ARVO Journals
5-fluorouracil and steroids have been used to suppress excessive scar formation after glaucoma filtering surgery (GFS). Steroidal and nonsteroidal antiinflammatory drugs (NSAIDs), which are inhibitors of arachidonic acid (AA) pathway, both limit fibroblast activity and reduce inflammation. In this experiment, the ability of corticosteroid (dexamethasone sodium phosphate), cyclooxygenase inhibitor (piroxicam), lipoxygenase inhibitor (ferulic acid), and dual cyclo/lipoxygenase inhibitor (phenidone) to inhibit human Tenons fibroblast proliferation was evaluated in culture. After human Tenons fibroblast cell lines were established, a complete dose-response curve was done for the representative compounds for 8 days. Fibroblast attachment and proliferation were quantified by Coulter counter, hexosaminidase, and tritiated thymidine uptake assays. All four drugs inhibited attachment and proliferation at high concentrations. Phenidone was the most effective, with inhibition occurring within the ...
JCI - Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.
Alternative splicing of the human glucocorticoid receptor (hGR) pre-mRNA generates two highly homologous isoforms, termed hGR alpha and hGR beta. hGR alpha is a ligand-activated transcription factor which, in the hormone-bound state, modulates the expression of glucocorticoid-responsive genes by binding to specific glucocorticoid response element (GRE) DNA sequences. In contrast, hGR beta does not bind glucocorticoids and is transcriptionally inactive. We demonstrate here that hGR beta is able to inhibit the effects of hormone-activated hGR alpha on a glucocorticoid-responsive reporter gene in a concentration-dependent manner. [3H]-Dexamethasone binding studies indicate that hGR beta does not alter the affinity of hGR alpha for its hormonal ligand. The presence of hGR beta in nuclear extracts and its ability to bind to a radiolabeled GRE oligonucleotide suggest that its inhibitory effect may be due to competition for GRE target sites. Reverse transcription-PCR analysis shows expression of hGR ...
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Dexamethasone Ampoules Composition: Each ampoule (2 ml) contains: Dexamethasone sodium phosphate (equivalent to 8 mg Dexamethasone). Properties and Mechanism of Action: Dexamethasone is a synthetic […]. ...
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Comparison of the Effect of Ondansetrone - Dexamethasone, Dexamethasone - Metoclopeamide and Ondansetron - Normal Saline in...
Background: The incidence of post-operative nausea and vomitting (PONV) is increased after middle ear surgery and it may complicate and interact with reconstruction after surgery, so prevention and treatment of these complications are necessary. The aim of this study was to evaluate the efficacy of anti-emetic combinations in decreasing the PONV after middle ear surgery. Materials and methods: This double blind clinical trial was carried out during 2007-2008 on 111 patients of 15-45 years old with ASA I-II who were candidates for elective middle ear surgery under general anesthesia. The patients were divided into three groups. Patients in the ON group received Ondansetrone 0.1mg/kg + Nacl 0.9% 2cc, OD group received Ondansetrone 0.1mg/kg + Dexamethasone 0.15mg/kg and MD group received Dexamethasone 0.15mg/kg+ Metoclopramide 0.15mg/kg intravenously just before the end of surgery. The patients were evaluated for nausea, vomiting, need of anti-emetic drugs and drug dosage in recovery, 1-6, 6-12 and 12-24
Corticosteroid offers rapid relief in croup - MJA InSight 45, 28 November 2011 | doctorportal
CHILDREN with croup start to improve within 30 minutes of receiving an oral corticosteroid, which is much faster than previously thought, according to new Australian research.. The double-blind trial involved 70 children presenting with croup to the emergency department at Princess Margaret Hospital for Children in Perth. They were randomly assigned to receive either placebo or 0.15mg/kg dexamethasone immediately on presentation. After 1 hour, all children received 0.15mg/kg dexamethasone.. After 10 minutes, the Westley croup scores of the children in the immediate dexamethasone treatment group were already trending lower than those in the placebo group. By 30 minutes, the difference in croup scores had reached statistical significance.. The results were presented at last weeks annual scientific meeting of the Australasian College for Emergency Medicine held in Sydney.. The study found thatdexamethasone for croup worked much faster than reported by a recent Cochrane Review, which stated that ...
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Does The Addition Of Dexamethasone To Local Anesthetic Used For Periph by Janice M. Oliveira
Pain after orthopedic surgery can be intense. Many anesthesia providers and orthopedic surgeons support the use of peripheral nerve blockade to assist in decreasing the amount of pain a patient may experience post operatively. Select medication adjuncts are being added to peripheral nerve blocks to prolong analgesia. The research presented here focuses on the addition of dexamethasone to peripheral nerve blocks to prolong analgesia. Dexamethasone is a synthetic glucocorticoid that acts as an anti-inflammatory. It has been shown to inhibit the release of inflammatory mediators such as, interleukins and cytokines, facilitating the release of anti-inflammatory mediators, decreasing postoperative pain. Recent evidence demonstrates a potential role of dexamethasone in postoperative pain management, both as a systemic analgesic and as an adjunct to local anesthetics for perineural use. A single preoperative dose of dexamethasone has been shown to be an effective adjunct to reduce postoperative pain and opioid
The effect of antenatal dexamethasone administration on the fetal and neonatal ductus arteriosus. A randomized double-blind...
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Influence of pyramid environment on the wound healing effects of dexamethasone and indomethacin - a comparative study<...
TY - JOUR. T1 - Influence of pyramid environment on the wound healing effects of dexamethasone and indomethacin - a comparative study. AU - Surekha, Kamath. PY - 2011/12/1. Y1 - 2011/12/1. N2 - Shapes and angles of The Great Pyramid of Egypt are balanced and renowned for their energy properties. Studies have proved that beneficial effects are found on human health in pyramidal environment. The present study was designed to determine the efficacy of dexamethasone and indomethacin on incision and dead space wound models in rats under the influence of pyramid environment. A wooden pyramid model fabricated locally was used for the study. The parameters chosen were breaking strength of incised wound, breaking strength of granulation tissue, hydroxyproline content and histology. The results showed that the dexamethasone and indomethacin slow down all phases of wound healing and the inhibitory action of dexamethasone on wound healing was stronger than that of indomethacin. Thus pyramid exposure ...
Antiemetic Efficacy of High-Dose Dexamethasone in Induction Therapy in Acute Nonlymphocytic Leukemia | Annals of Internal...
Nausea and vomiting continue to be distressing side effects of cancer chemotherapy. We recently reported (1) a randomized, double-blind study in which a single 10-mg dose of intravenous dexamethasone markedly reduced the gastrointestinal side effects of mildly emetogenic chemotherapy for outpatients with breast cancer. We now report the safety and efficacy of repeated doses of dexamethasone in eliminating the nausea and vomiting of induction chemotherapy for patients with acute nonlymphocytic leukemia.. All patients included in the study were adults with acute nonlymphocytic leukemia (at diagnosis or on relapse) at the Hospital of the University of Pennsylvania and were treated with ...
Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells. | Molecular and Cellular...
We used a dominant inhibitory mutation of c-Ha-ras which changes Ser-17 to Asn-17 in the gene product p21 [p21(Asn-17)Ha-ras] to investigate ras function in mitogenic signal transduction. An NIH 3T3 cell line [NIH(M17)] was isolated that displayed inducible expression of the mutant Ha-ras gene (Ha-ras Asn-17) via the mouse mammary tumor virus long terminal repeat and was growth inhibited by dexamethasone. The effect of dexamethasone induction on response of quiescent NIH(M17) cells to mitogens was then analyzed. Stimulation of DNA synthesis by epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) was completely blocked by p21(Asn-17) expression, and stimulation by serum, fibroblast growth factor, and platelet-derived growth factor was partially inhibited. However, the induction of fos, jun, and myc by EGF and TPA was not significantly inhibited in this cell line. An effect of p21(Asn-17) on fos induction was, however, demonstrated in transient expression assays in which ...
Wildlife Welfare: The effect of park management factors on glucocorticoid receptor levels in the hippocampus and cortisol...
Wildlife Welfare: The effect of park management factors on glucocorticoid receptor levels in the hippocampus and cortisol levels in hair of fallow deer (Dama dama) from wildlife parks in the UK and in the Netherlands as indicators for chronic ...
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Panobinostat Combined With Bortezomib and Dexamethasone Can Recapture Responses in Heavily Pretreated Patients With Multiple...
The combination of the investigational histone deacetylase inhibitor panobinostat (Faridak) with bortezomib (Velcade) and dexamethasone was able to recapture responses in 34.5% of heavily pretreated, bortezomib-refractory patients with multiple myeloma in the phase II PANORAMA 2 trial. The 55 patients enrolled at 12 trial sites had a median of four prior regimens, including two prior regimens with bortezomib. The responses at the end of the first treatment phase cycles included 1 near-complete response and 18 partial responses. An additional 10 patients achieved minimal response, for a clinical benefit rate of 52.7%, reported Paul G. Richardson, MD, of Dana-Farber Cancer Institute and Harvard Medical School, Boston, and colleagues. The investigators published their results online in Blood.. Responses in the remainder of patients consisted of stable disease in 20 patients (36.4%) and progressive disease in 3 patients (5.5%). Response could not be assessed in the remaining 3 patients (5.5%) due ...
Effects of Dexamethasone on Distributions of Water and Pertechnetate in Brains of Cats After Middle Cerebral Artery Occlusion |...
Large parenteral doses of dexamethasone were given to five of ten cats after transorbital occlusion of one middle cerebral artery and to two of four cats after sham operations. Two days later the water content and brain/blood ratios of pertechnetate were measured in samples of cerebral tissue that were categorized as nonischemic, ischemic, or infarcted. Values for infarcted tissue were greater than those for ischemic tissue in untreated cats, but not in cats that received dexamethasone. The drug had no apparent effect in ischemic tissue that was not necrotic. These results help explain inconsistencies in previous studies and help define the potential usefulness of dexamethasone for treatment of cerebrovascular disease.. ...
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Effect of inflammatory arthritis on dexamethasone receptors in phagocytes-a possible role for plasma factors | SpringerLink
Synovial tissue cells from patients with seropositive rheumatoid arthritis bind dexamethasone in a similar fashion to the classical steroid receptors on other cells. In contrast, synovial fluid cells...
Most recent papers with the keyword anesthesia and analgesia | Read by QxMD
BACKGROUND: Peripheral nerve block (infiltration of local anaesthetic around a nerve) is used for anaesthesia or analgesia. A limitation to its use for postoperative analgesia is that the analgesic effect lasts only a few hours, after which moderate to severe pain at the surgical site may result in the need for alternative analgesic therapy. Several adjuvants have been used to prolong the analgesic duration of peripheral nerve block, including perineural or intravenous dexamethasone. OBJECTIVES: To evaluate the comparative efficacy and safety of perineural dexamethasone versus placebo, intravenous dexamethasone versus placebo, and perineural dexamethasone versus intravenous dexamethasone when added to peripheral nerve block for postoperative pain control in people undergoing surgery ...
In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infants | ADC Fetal & Neonatal Edition
We tested the effects of DP on erythroid and granulocyte-macrophage colony formation in progenitor cells from preterm infants and adults. The concentrations of DP included in the culture dishes ranged from 10−6 M to 10−9M. Studies on the pharmacokinetics of DP in preterm infants have shown that the plasma concentrations reached following DP administrations are in the order of magnitude of 10−6 M to 10−8M.7 It is not known, however, whether these concentrations will be achieved in the bone marrow, nor whether interactions with other hormones or mediators in the bone milieu will influence the effect of DP on haematopoietic progenitors. In our experimental conditions DP showed a dose dependent inhibitory effect on both erythroid and granulocyte-macrophage colonies derived from progenitor cells of preterm infants. CFU-E colonies were the most affected, with significant reductions observed at all concentrations of DP. This profound reduction in erythroid colonies was not apparent with bone ...
Dexamethasone treatment in vitro resulted in different responses of two fractions of phagocytes of the holothurian Eupentacta...
Read Dexamethasone treatment in vitro resulted in different responses of two fractions of phagocytes of the holothurian Eupentacta fraudatrix, Russian Journal of Marine Biology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Abstract 11: Physical Therapy Equipment, Supplies & Products - Isokinetics Inc.
We have demonstrated the dexamethasone sodium phosphate (DmNaP) is delivered most efficiently from the negative electrode by iontophoresis, but, under certain conditions, the delivery from the positive electrode by electroosmosis can be accomplished. The laboratory data indicate that more dexamethasone is delivered per mA-min by iontophoresis than by electtoomosis, thus the same amount of drug can be administered in a shorter time from the negative electrode. Electrodes containing a hydrogel material, which restricts bulk water transport, delivered DmNaP most efficiently from the electrode of a negative polarity. When DmNaP is to be delivered in a mixture with another drug such as lidocaine, selection of the clinical treatment protocol depends on the desired therapeutic effect on the iontophoreic electrode which is to be used. When minimization of total treatment time is not critical, switching polarity of the electrode during the treatment can be used to administer drugs of opposite polarity ...
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Positive Data from Cynata MSCs in Second Preclinical Asthma Study | BioInformant
The study was conducted under the supervision of Associate Professor Samuel and Dr Simon Royce of the Monash Lung Biology Network,1 focusing on the effects of CymerusTM MSCs in combination with or in comparison to the corticosteroid dexamethasone, which is commonly used to treat exacerbations of asthma in human patients. The study used a well-established mouse model of chronic allergic airways disease that closely resembles asthma in humans. This part of the study focused on airway hyperresponsiveness (AHR), which is a key clinical manifestation of asthma.. Initial results from this study have demonstrated that, as expected, treatment with dexamethasone alone significantly improved AHR compared to untreated controls (p,0.05). However, treatment with either Cymerus™ MSCs alone, or Cymerus™ MSCs in combination with dexamethasone, resulted in a substantially greater suppression of AHR, which was significantly superior to that seen with dexamethasone treatment alone (p,0.01). All treatments were ...
Single Dose Oral Dexamethasone for Pediatric Asthma - Is It an Alternative to the 5-day Prednisone or Prednisolone Burst? | To...
Cico S. Cico S Cico, Stephen John.. Single Dose Oral Dexamethasone for Pediatric Asthma - Is It an Alternative to the 5-day Prednisone or Prednisolone Burst?. To the Point: Clinical Reviews Tintinalli JE. Tintinalli J.E. Tintinalli, Judith E. New York, NY: McGraw-Hill, 2016, http://accessemergencymedicine.mhmedical.com/updatesContent.aspx?gbosid=367734§ionid=159414917. ...
Glucocorticoid receptor in polymorphonuclear leukocytes: A simple method for leukocyte glucocorticoid receptor characterization...
TY - JOUR. T1 - Glucocorticoid receptor in polymorphonuclear leukocytes. T2 - A simple method for leukocyte glucocorticoid receptor characterization. AU - Murakami, Tohru. AU - Brandon, David. AU - Rodbard, David. AU - Loriaux, Donald (Lynn). AU - Lipsett, Mortimer B.. PY - 1979. Y1 - 1979. N2 - Glucocorticoid receptors of polymorphonuclear leukocytes (PMN) have been characterized and compared with those of mononuclear leukocytes (MNL). Cytosol receptors from PMN and MNL have similar binding affinities for [3H]-dexamethasone (Dex). nearly superimposable sedimentation profiles on sucrose density gradients, and similar elution patterns from DEAE-Sephadex. Thus, the glucocorticoid receptors of MNL and PMN have similar biochemical properties. We have developed a simple method for preparing leukocytes from 20 ml of blood to characterize and quantify the glucocorticoid receptor. The Scatchard analysis of [3H]-Dex binding to intact leukocytes shows a single class of binding sites; the apparent Kd was ...
Repositório da Universidade de Lisboa: Application of biodegradable polymers in formulation of parenteral dosage forms
This work is composed by two parts that will be presented separately as follows: Assessment of swelling of PLGA based implants and drug release at the site of administration: The aim of this study was to investigate the counter-pressure of adipose tissue. Force-distance curves were used to measure the required force to squeeze out a certain volume of water in the balloon. Three catheters with different volumes were placed in the air and in the tissue (chicken and pork tissue). The counter-pressure of adipose tissue on implants was higher as bigger as the implants were. Implant formulations which tend to swell more, will be more suppressed by surrounding tissue at the site of administration and, consequently, the drug release of these formulations will decrease. Thus, the swelling of PLGA based implants and drug release at the site of administration were investigated. Two different loading of dexamethasone sodium phosphate implants were prepared (10% and 30%). The implants containing 10% and 30% ...
Dexamethasone. *Flunisolide (Nasarel). *Fluticasone. *Fluticasone furoate (Veramyst). *Fluticasone propionate (Flonase) * ...
WHO Model List of Essential Medicines
Dexamethasone. *Tranexamic acid. Medicines administered to the neonate. *Caffeine citrate. *Chlorhexidine ...
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Medications include: dexamethasone Butyrophenones: Typically administered as a single injection at the end of surgery. Adverse ...
"Dexamethasone". drugs.com. Archived from the original on 21 June 2013. Retrieved 14 June 2013. Caldato MC, Fernandes VT, Kater ... Compared to hydrocortisone, prednisolone is about 4 times as potent and dexamethasone about 40 times as potent in terms of anti ...
... or dexamethasone. Rapid injection of one of these drugs may stop a severe allergic reaction. Multiple sclerosis patients may ...
Additional treatment with corticosteroids (usually dexamethasone) has shown some benefits, such as a reduction of hearing loss ... McIntyre PB, Berkey CS, King SM, Schaad UB, Kilpi T, Kanra GY, Perez CM (September 1997). "Dexamethasone as adjunctive therapy ... Professional guidelines therefore recommend the commencement of dexamethasone or a similar corticosteroid just before the first ... some guidelines suggest that dexamethasone be discontinued if another cause for meningitis is identified. The likely ...
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Dexamethasone-induced Ras-related protein 1 (RASD1) is a protein that in humans is encoded by the RASD1 gene on chromosome 17.[ ... "RASD1 - Dexamethasone-induced Ras-related protein 1 precursor - Homo sapiens (Human) - RASD1 gene & protein". www.uniprot.org. ... RASD1, AGS1, DEXRAS1, MGC:26290, ras related dexamethasone induced 1. External IDs. MGI: 1270848 HomoloGene: 7509 GeneCards: ... Kemppainen RJ, Behrend EN (Feb 1998). "Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 ...
Considine RV, Nyce MR, Kolaczynski JW, Zhang PL, Ohannesian JP, Moore JH, Fox JW, Caro JF (May 1997). "Dexamethasone stimulates ... Leptin release is increased by dexamethasone. In obese patients with obstructive sleep apnea, leptin level is increased, but ...
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The Japanese Health Ministry approved the use of dexamethasone to treat moderate or advanced cases of COVID-19, after trials ... Wong, Jacqueline (22 July 2020). "Japan approves dexamethasone as coronavirus treatment". Reuters. Archived from the original ...
GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK. Many ...
In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal ... "Trichlormethiazide and Dexamethasone for veterinary use". Wedgewood Pharmacy. Retrieved 2008-01-24. GB 949373, "Benzthiadiazine ...
Dreger, A; Feder, E.K.; Tamar-Mattis, A (Jul 2012). "Prenatal Dexamethasone for Congenital Adrenal Hyperplasia: An Ethics ... ". "Medical Ethics: Prenatal Dexamethasone Use Questioned". Time. 18 June 2010. Slate "If Your Baby Girl Might Be Born With a ...
Treatment and management of COVID-19
"Q&A: Dexamethasone and COVID-19". World Health Organization (WHO). Retrieved 2020-07-11. "Home". National COVID-19 Clinical ... In those with low oxygen levels, use of the glucocorticoid dexamethasone is strongly recommended, as it can reduce the risk of ... Dexamethasone has clinical benefit in treating COVID-19, as determined in randomized controlled trials. Early research ... In the European Union, the use of dexamethasone is endorsed, and remdesivir has a conditional marketing authorisation. ...
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Intravitreal injection of Dexamethasone implant (Ozurdex; 700,350 μg) is being studied, its effect may last for 180 days. The ... December 2011). "Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein ...
Common corticosteroids include dexamethasone and betamethasone. Dexamethasone is often recommend over the latter due to its ... Liggins found that dexamethasone caused pregnant sheep to deliver their fetuses prematurely, however, despite the fact that the ... "Dexamethasone versus betamethasone as an antenatal corticosteroid (ACS)" (PDF). UN Commission / Born Too Soon Care Antenatal ... Literature on the subject is limited and inconsistent, with some research indicating that dexamethasone decreases risks of ...
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Another alternative is dexamethasone with vancomycin and meropenem. Pericarditis can appear, either as a septic pericarditis ...
Responses to the COVID-19 pandemic in June 2020
"Welcoming early results on use of dexamethasone in sickest COVID-19 patients, WHO warns it's 'no cure-all'". UN News. 17 June ... The World Health Organization welcomed early results on use of dexamethasone in sickest COVID-19 patients, while warning it's ' ... Mukherjee, Promit (23 June 2020). "S. Africa's Aspen says it has capacity to meet demand for dexamethasone". Reuters. Archived ... Roberts, Michelle (16 June 2020). "Coronavirus: Dexamethasone proves first life-saving drug". BBC. Archived from the original ...
Anías-Calderón, José; Verdugo-Díaz, Leticia; Drucker-Colín, René (2004). "Adrenalectomy and dexamethasone replacement on ...
"Dokter Reisa: Dexamethasone Bukan Penangkal COVID-19". Indonesian National Board for Disaster Management and COVID-19 Response ...
Symonds, C. P.; Harris, PW; Lessof, MH; Lyne, C (1943). "Singledose dexamethasone suppression test for Cushing's Syndrome". BMJ ...
COVID-19 drug development
Roberts M (16 June 2020). "Coronavirus: Dexamethasone proves first life-saving drug". BBC News Online. "Dexamethasone reduces ... Dexamethasone was closed to new adult entries after positive results and by November 2020, was open to child entries. COVID-19 ... "Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID ... In a controlled trial around 2,000 hospital patients were given dexamethasone and were compared with more than 4,000 who did ...
Genetic diagnosis of intersex
Treatment with dexamethasone was discontinued in Sweden. Intersex medical interventions Preimplantation genetic diagnosis Sex ... Dreger, Alice; Feder, Ellen K.; Tamar-Mattis, Anne (September 2012). "Prenatal Dexamethasone for Congenital Adrenal Hyperplasia ... Hirvikoski, Tatja; Nordenström, Anna; Wedell, Anna; Ritzén, Martin; Lajic, Svetlana (June 2012). "Prenatal Dexamethasone ... and potentially preventable with prenatal dexamethasone". The authors state that "weak and unsupported conclusions" of ...
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Dexamethasone: MedlinePlus Drug Information
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Dexamethasone | Encyclopedia.com
Dexamethasone Definition Dexamethasone is a synthetic glucocorticoid. Its naturally occuring counterparts are hydrocortisone ... Dexamethasone Gale Encyclopedia of Cancer COPYRIGHT 2002 The Gale Group Inc.. Dexamethasone. Definition. Dexamethasone is a ... In non-Hodgkins lymphoma (NHL), dexamethasone is part of a drug regimen known as "DHAP." Here, dexamethasone is given with ... Patients should not stop taking dexamethasone without first consulting their physician. When dexamethasone treatment stops, it ...
Dexamethasone | chemistry | Britannica.com
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dexamethasone | American Academy of Pediatrics
Dexamethasone for Acute Asthma Exacerbations in Children: A Meta-analysis Grant E. Keeney, Matthew P. Gray, Andrea K. Morrison ... Dexamethasone Therapy Increases Infection in Very Low Birth Weight Infants Barbara J. Stoll, Marinella Temprosa, Jon E. Tyson, ... Early Postnatal Dexamethasone Therapy for the Prevention of Chronic Lung Disease The Vermont Oxford Network Steroid Study Group ... Topical Ciprofloxacin/Dexamethasone Otic Suspension Is Superior to Ofloxacin Otic Solution in the Treatment of Children With ...
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Dexamethasone/rituximab | SpringerLink
Rai MP, et al. Rituximab (RITUX) maintenance infusions in immune thrombocytopenia (ITP) to prolong remission following relapse after initial ritux induction but responded to a second course. Blood 132 (Suppl. 1): abstr. 3753, Nov 2018. Available from: URL: https://ash.confex.com/ash/2018/webprogram/Paper114242.html [abstract] - USA ...
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Dexamethasone/fludarabine/mitoxantrone | SpringerLink
Dexamethasone/fludarabine/mitoxantrone. Acute promyelocytic leukaemia and myelodysplastic syndromes: 4 case reports ... and dexamethasone. American Journal of Hematology 81: 471-473, No. 6, Jun 2006 - Hong Kong ... Dexamethasone/fludarabine/mitoxantrone. React. Wkly. 1116, 13 (2006). https://doi.org/10.2165/00128415-200611160-00037 ...
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Dexamethasone oral tablet is a prescription medication used to treat conditions such as inflammation, allergic reactions, ... Also, dexamethasone may hide the signs of a non-fungal infection.. For people with congestive heart failure: Dexamethasone can ... Highlights for dexamethasone. *Dexamethasone oral tablet is available as both a generic and brand-name drug. Brand name: DexPak ... When used with dexamethasone, this drug can increase the amount of dexamethasone in your body. This raises your risk of side ...
dexamethasone - Pregnancy: Age 35+ - MedHelp
has anyone being asked to take dexamethasone due to high 17 OHP result? My 17 OHP was 64.0 and was told that it was too high ( ... dexamethasone. has anyone being asked to take dexamethasone due to high 17 OHP result? My 17 OHP was 64.0 and was told that it ... has anyone being asked to take dexamethasone due to high 17 OHP result? My 17 OHP was 64.0 and was told that it was too high ( ...
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DEXAMETHASONE (dex a METH a sone) is a corticosteroid. It is used to treat swelling, redness, itching, and allergic reactions ... Dexamethasone eye drops. What is this medicine?. DEXAMETHASONE (dex a METH a sone) is a corticosteroid. It is used to treat ... an unusual or allergic reaction to dexamethasone, corticosteroids, other medicines, foods, dyes, or preservatives ...
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DailyMed - DEXAMETHASONE tablet
Dexamethasone suppression tests:. 1. Tests for Cushings syndrome. Give 1 mg of dexamethasone tablets, USP orally at 11:00 p.m ... Dexamethasone suppression test (DST): False-negative results in the dexamethasone suppression test (DST) in patients being ... Dexamethasone tablets, USP, 1.5 mg, are for oral administration. Each tablet contains 1.5 mg of dexamethasone. Inactive ... Dexamethasone Sodium Phosphate injection, USP 4 mg per mL:. First Day. 1 or 2 mL, intramuscularly. Dexamethasone tablets, USP, ...
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DEXAMETHASONE (dex a METH a sone) is a corticosteroid. It is placed in the eye during a procedure and is used to help treat ... Dexamethasone intravitreal implant. What is this medicine?. DEXAMETHASONE (dex a METH a sone) is a corticosteroid. It is placed ... an unusual or allergic reaction to dexamethasone, corticosteroids, other medicines, foods, dyes, or preservatives ...
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Dexamethasone (Decadron®) | OncoLink
Dexamethasone is a glucocorticoid (steroid) with multiple uses, including decrease swelling, prevent allergic reactions or ... How to Take Dexamethasone. Dexamethasone comes as a tablet or liquid to be taken by mouth. Dexamethasone can also be given ... About: Dexamethasone (Decadron®) Dexamethasone is a corticosteroid, similar to a hormone that is made naturally in your body. ... Oral tablet form dexamethasone is best taken with food, as it can irritate your stomach. Oral dexamethasone liquid should be ...
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Dexamethasone in adults with bacterial meningitis
Early treatment with dexamethasone improves the outcome in adults with acute bacterial meningitis and does not increase the ... Dexamethasone in adults with bacterial meningitis N Engl J Med. 2002 Nov 14;347(20):1549-56. doi: 10.1056/NEJMoa021334. ... Jan de Gans 1 , Diederik van de Beek, European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators ... Dexamethasone (10 mg) or placebo was administered 15 to 20 minutes before or with the first dose of antibiotic and was given ...
Dexamethasone (Oral Route) Precautions - Mayo Clinic
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Carers UK Forum • dexamethasone
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- Dexamethasone, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. (medlineplus.gov)
- Dexamethasone is a synthetic (created by a chemical processes) corticosteroid hormone like prednisone , betamethasone, and triamcinolone. (medicinenet.com)
- If dexamethasone is absolutely needed and breastfeeding cannot be stopped, a separation of 4 hours between therapy and breastfeeding is recommended to decrease exposure of the infant to the corticosteroid. (medicinenet.com)
- TOBRADEX® ST (tobramycin / dexamethasone ophthalmic suspension 0.3%/0.05%) ophthalmic suspension is indicated for steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists. (medicinenet.com)
- Dexamethasone is a synthetic corticosteroid that can be administered into the eyes to decrease inflammation. (netdoctor.co.uk)
- DEXAMETHASONE (dex a METH a sone) is a corticosteroid. (nationwidechildrens.org)
- Dexamethasone is a corticosteroid, similar to a hormone that is made naturally in your body. (oncolink.org)
- The primary corticosteroid used to control cerebral edema is dexamethasone. (medscape.com)
- Dexamethasone has been the corticosteroid of choice in this patient population because of its high potency relative to other agents, its low mineralocorticoid (sodium retaining) effect, and its long biologic half-life (i.e., 48 hours). (medscape.com)
- Dexamethasone is a corticosteroid (cortisone-like medicine or steroid). (mayoclinic.org)
- Like most corticosteroid medicines, dexamethasone is not generally recommended for use during pregnancy. (news-medical.net)
- Dexamethasone is a corticosteroid used as an anti-inflammatory to treat a variety of conditions including lupus, acute arthritis, allergies, cancers, brain swelling, and other conditions. (1800petmeds.com)
- Dexamethasone is the most commonly prescribed corticosteroid in myeloma. (myeloma.org)
- Dexamethasone itself is of course a steroid derivative, a corticosteroid that is used to damp down inflammation and immune response.Such compounds have a huge number of downstream effects in cells and in organ systems (among them a decrease in IL-6 signaling). (sciencemag.org)
- A corticosteroid, dexamethasone is used primarily to control inflammation within the body caused by diseases and medical conditions such as asthma and allergies. (medicaldaily.com)
- Dexamethasone is a synthetic corticosteroid used to treat different inflammatory conditions like ulcerative colitis , lupus, allergy disorders, skin conditions, psoriasis , arthritis, and breathing disorders. (rebates.com)
- A single capsule of an oral corticosteroid like dexamethasone may not increase the likelihood of complete symptom resolution after 24 hours, among patients who do not require antibiotics. (medindia.net)
- Dexamethasone Sodium Phosphate is classified as a corticosteroid. (pattersondental.com)
- For the moment, the corticosteroid dexamethasone is still the only therapeutic shown to be effective against COVID-19, for patients with severe disease, Tedros. (mercopress.com)
- DECADRON® (dexamethasone tablets, USP) tablets, for oral administration, are supplied in two potencies, 0.5 mg and 0.75 mg. (rxlist.com)
- Take dexamethasone exactly as directed. (medlineplus.gov)
- if you have a fungal infection (other than on your skin), do not take dexamethasone without talking to your doctor. (medlineplus.gov)
- Take dexamethasone with food or milk. (medlineplus.gov)
- When you start to take dexamethasone, ask your doctor what to do if you forget a dose. (medlineplus.gov)
- If you take dexamethasone once a day, take the missed dose as soon as you remember it. (medlineplus.gov)
- Who should not take Dexamethasone 10 Mg/Ml Injection Solution? (webmd.com)
- has anyone being asked to take dexamethasone due to high 17 OHP result? (medhelp.org)
- I used to take dexamethasone when I was having chemo. (carersuk.org)
- In the open label phase, patients assigned to either arm asked to take Dexamethasone 4 mg orally twice a day for 7 days. (clinicaltrials.gov)
- this will be followed by an open label phase in which patients in both arms would take dexamethasone for 7 days. (clinicaltrials.gov)
- How should I take dexamethasone? (wellspan.org)
- Please take Dexamethasone Tablet 2mg as prescribed by your doctor or medical professional. (chemistdirect.co.uk)
- Dexamethasone is a synthetic glucocorticoid. (encyclopedia.com)
- More specifically, dexamethasone is a glucocorticoid hormone, which means that it has anti-inflammatory effects, as well as the ability to affect blood glucose use, fat breakdown, and bone development depending on where it binds in the body. (medicinenet.com)
- 1981). Tumors that respond well to dexamethasone, such as cerebral metastases, are characterized by high levels of glucocorticoid receptors. (medscape.com)
- Dexamethasone is a glucocorticoid medication used to treat rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, eye pain following eye surgery, and along with antibiotics in tuberculosis. (wikipedia.org)
- Dexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. (wikipedia.org)
- To determine if administration of the potent glucocorticoid dexamethasone down-regulates SkM androgen receptor and the IGF-1 signalling pathway. (ingentaconnect.com)
- DEXAMETHASONE MYLAN is a glucocorticoid and belongs to a group of medicines called corticosteroids. (news-medical.net)
- Dexamethasone is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression. (mpbio.com)
- The reason for this controversy, of course, is that dexamethasone is a glucocorticoid with many feared side effects when used in the perioperative patient population. (lww.com)
Dose of dexamethasone6
- Trump received oxygen for about an hour Friday after his oxygen levels dropped briefly, his doctors said Sunday, and his oxygen saturation dipped to 93%, which prompted them to give a dose of dexamethasone. (medscape.com)
- If you are on a daily dose of dexamethasone (usually less than 10 mg), and you miss a dose, take the dose as soon as you remember. (chemocare.com)
- The dose of DEXAMETHASONE MYLAN is variable, depending on the condition being treated. (news-medical.net)
- The usual dose of dexamethasone is dependent on the condition being treated and the pet's response to the treatment. (1800petmeds.com)
- Adult patients with mild to moderate asthma who came to the emergency department were randomly assigned to one of two groups: a single dose of dexamethasone with 4 days of placebo to be taken at home or a 5-day course of oral prednisone. (medicalnewstoday.com)
- In subjects with Cushing disease, a higher dose of dexamethasone (usually 8 mg) is required to suppress ACTH secretion and drop cortisol level in serum, urine, and saliva. (medscape.com)
- Dexamethasone reduces inflammation by preventing immune cells, such as neutrophils, from migrating to the site of action, reducing the release of inflammatory signals, as well as decreasing how well substances may pass in and out of the blood vessels. (medicinenet.com)
- Dexamethasone eye drops may be used to reduce redness, burning, and swelling or inflammation in the ear. (medlineplus.gov)
- Tobramycin and dexamethasone (Tobradex, Tobradex ST) is a medication prescribed for the treatment of steroid responsive ocular inflammation that requires steroid treatment, and is caused by a bacterial infection, or if there is a risk of infection. (medicinenet.com)
- The dexamethasone oral tablet is used to treat conditions that cause inflammation, conditions related to immune system activity, and hormone deficiency. (medicalnewstoday.com)
- Steroids such as dexamethasone help block the immune system's response to inflammation, which helps prevent this damage. (medicalnewstoday.com)
- Dexamethasone belongs to a group of medicines known as corticosteroids that are used for reducing inflammation. (netdoctor.co.uk)
- Dexamethasone, which lessens cerebrospinal inflammation, has been shown to reduce the incidence of hearing loss in children with meningitis caused by Haemophilus influenzae type b and possibly Streptococcus pneumoniae . (cmaj.ca)
- Corticosteroids, including prednisone and dexamethasone , are sometimes prescribed to reduce inflammation and brain swelling. (yourdictionary.com)
- Dexamethasone relieves inflammation in various parts of the body. (chemocare.com)
- Dexamethasone Tablets are used for a number of conditions, including allergies, inflammation, certain types of colitis, and many other diseases. (1800petmeds.com)
- Trial results announced on Tuesday - but not yet peer reviewed - showed dexamethasone, which is used to reduce inflammation in other diseases such as arthritis, reduced death rates by about a third among the most severely ill COVID-19 patients admitted to hospital. (abc.net.au)
- Dexamethasone is given to lower inflammation and immune response, and that's exactly what it's doing here (and exactly why it was put into the Recovery trial in the first place - it's clearly something that you would want to investigate). (sciencemag.org)
- Because dexamethasone decreases inflammation, scientists suspected it might be helpful in treating COVID-19, as the disease can cause inflammation throughout the body. (medicaldaily.com)
- In patients with very high levels of C-reactive protein , which is produced by the liver in response to inflammation, corticosteroids like dexamethasone reduced the likelihood of mechanical ventilation or death by 75%, according to the U.S. study, which appeared in the Journal of Hospital Medicine. (yahoo.com)
- Dexamethasone is administered to prevent the release of substances that cause inflammation in body. (rebates.com)
- Dexamethasone can relieve the symptoms associated with inflammation (a process of the immune system) such as redness, itching, swelling, and allergic reactions. (rebates.com)
- Dexamethasone has been on the market for over 60 years and usually serves to reduce inflammation. (thejakartapost.com)
- Dexamethasone is a steroid that prevents the release of substances in the body that cause inflammation. (wellspan.org)
- Trial results announced on Tuesday by researchers in Britain showed dexamethasone, a generic drug used since the 1960s to reduce inflammation in diseases such as arthritis, cut death rates by around a third among the most severely ill coronavirus patients admitted to hospital. (theglobeandmail.com)
- Although corticosteroids decrease capillary permeability in the tumor itself, it has been found in animal models that dexamethasone may act differently and decrease edema by effects on bulk flow away from the tumor (Molnar, Lapin, & Goothuis, 1995). (medscape.com)
- Dexamethasone is in a class called corticosteroids. (1800petmeds.com)
- The efficacy of oral corticosteroids like dexamethasone remains uncertain for patients with sore throat. (medindia.net)
- Although the use of the anti-viral remdesivir is now standard for a wide range of COVID-19 patients, the steroid dexamethasone is considered safe only when a patient appears to be at high risk of developing the kind of overactive inflammatory response that can lead to organ failure and death. (yahoo.com)
- Two hours post-instillation, half of each group received either steroid (dexamethasone 8 mg/kg, i.p.), in an attempt to suppress cellular infiltration and function, or saline vehicle. (cdc.gov)
- Although the data are still preliminary, the recent finding that the steroid dexamethasone has life-saving potential for critically ill COVID-19 patients gave us a much-needed reason to celebrate,' Tedros told a virtual news conference in Geneva. (thejakartapost.com)
- my husband is currently coming off of the steroid dexamethasone, and it is hitting him hard! (cancer.org)
- We conducted a prospective, randomized, double-blind, multicenter trial of adjuvant treatment with dexamethasone, as compared with placebo, in adults with acute bacterial meningitis. (nih.gov)
- Dexamethasone (10 mg) or placebo was administered 15 to 20 minutes before or with the first dose of antibiotic and was given every 6 hours for four days. (nih.gov)
- A total of 301 patients were randomly assigned to a treatment group: 157 to the dexamethasone group and 144 to the placebo group. (nih.gov)
- Gastrointestinal bleeding occurred in two patients in the dexamethasone group and in five patients in the placebo group. (nih.gov)
- Patients were randomly assigned to receive either dexamethasone, 10 mg intravenously, or a placebo before or with the first dose of intravenous antibiotics and every 6 hours thereafter for a total of 4 days. (cmaj.ca)
- Results: Baseline demographic, clinical and CSF characteristics of the dexamethasone ( n = 157) and placebo ( n = 144) groups were comparable, with the exception that a higher percentage of patients in the dexamethasone group had seizures on presentation (10% v. 5% in the placebo group). (cmaj.ca)
- In this study, dexamethasone will be compared to a placebo. (clinicaltrials.gov)
- Overall, there was no significant difference in auditory outcome between dexamethasone and placebo recipients. (aappublications.org)
- Postoperative pain intensity at 12 hours after surgery was lower in the perineural dexamethasone group compared with placebo (5 studies, 257 participants, very low-quality evidence) and at 24 hours after surgery (9 studies, 469 participants, low-quality evidence). (cochrane.org)
- Rayburn, W.F., Christensen, H.D. and Gonzalez, C.L. (1997) A Placebo-Controlled Comparison between Betamethasone and Dexamethasone for Fetal Maturation: Differences in Neurobehavioral Development of Mice Offspring. (scirp.org)
- M.R.C.G.P., of the University of Oxford, United Kingdom, and colleagues randomly assigned adults with sore throat not requiring immediate antibiotics to a single oral dose of 10 mg of dexamethasone or placebo. (medindia.net)
- Of 565 eligible randomized participants (median age, 34 years), 288 received dexamethasone and 277 placebo. (medindia.net)
- The researchers found that at 24 hours, participants receiving dexamethasone were not more likely than those receiving placebo to have complete symptom resolution. (medindia.net)
- At 48 hours, more participants receiving dexamethasone than placebo (35 percent versus 27 percent) had complete symptom resolution, which was also observed in patients not offered delayed antibiotics. (medindia.net)
- Dexamethasone helps to reduce cancer-related fatigue in patients with advanced disease, according to a double-blind, randomized, placebo-controlled trial published in the Journal of Clinical Oncology ( 2013;31:3076-3082 ). (nursingcenter.com)
- The study included 84 patients with advanced cancer-43 taking dexamethasone at 4 mg twice daily and 41 receiving placebo, with a 15-day follow-up. (nursingcenter.com)
- At day 15, the primary endpoint of the Functional Assessment of Chronic Illness-Fatigue (FACIT-F) subscale was significantly higher in patients receiving dexamethasone than in those taking placebo (9 +/- 10.3 vs. 3.1 +/- 9.59). (nursingcenter.com)
- FACIT-F total quality-of-life scores were also significantly better at day 15 in the dexamethasone group than in placebo patients (18.16 +/- 22.88 vs. 7.87 +/- 19.93). (nursingcenter.com)
- The ESAS physical distress score at day 15 was also significantly better for the dexamethasone group than the placebo group (-10.86 +/- 9.55 vs. -4.78 +/- 10.86). (nursingcenter.com)
- While dexamethasone did not have a significant impact on anxiety or depression outcomes as measured by the Hospital Anxiety and Depression Scale (HADS), the drug did significantly improve Functional Assessment of Cancer Therapy-Anorexia-Cachexia (FAACT) scores at day 15 compared with placebo (6.82 +/- 8.95 vs 1.95 +/- 8.54). (nursingcenter.com)
- The frequency of adverse events was not significantly different between those taking dexamethasone and placebo, the researchers reported. (nursingcenter.com)
- Patients taking large doses of dexamethasone should try to take the drug with meals. (encyclopedia.com)
- At equipment anti-inflammatory doses, dexamethasone almost completely lacks the sodium-retaining property of hydrocortisone and closely related derivatives of hydrocortisone. (nih.gov)
- Dexamethasone may be given to prevent a reaction to a medication, prevent or decrease nausea or be used in high doses to treat certain cancers. (oncolink.org)
- Other steroids at equivalent doses probably also work, but given the clinical ease of use and comfort, dexamethasone is used. (medscape.com)
- High doses can be more harmful than helpful, so doctors need to be careful about giving dexamethasone at the right time during a COVID-19 illness, the authors say, typically after the first week of illness. (medscape.com)
- If you are on high doses of dexamethasone (20 mg or 40 mg per day for 4 days out of the month), and you miss your dose, contact your healthcare provider. (chemocare.com)
- In the treatment of acute exacerbations of multiple sclerosis, daily doses of 30 mg of dexamethasone for a week followed by 4 to 12 mg every other day for one month have been shown to be effective (see PRECAUTIONS , Neuro-Psychiatric ). (rxlist.com)
- Adult male Swiss albino mice assigned to five groups were given vehicle (normal saline), a standard drug (Diazepam or Scopolamine) or one of three selected doses of dexamethasone (0.5, 1.0 and 1.5 mg/kg) daily for a period of 14 days. (scirp.org)
- Britain has increased the amount of dexamethasone it has in stock and on order to 240,000 doses, Health Minister Matt Hancock said. (theglobeandmail.com)
- Cushing's disease caused by an adrenal gland tumor is resistant to the effects of both low and high doses of dexamethasone. (vcahospitals.com)
- Therefore, failure of blood cortisol levels to decrease after using both the low and high doses of dexamethasone is supportive of an adrenal origin to the Cushing's disease. (vcahospitals.com)
- Ophthalmic solution or ointment: 0.3% tobramycin and 0.1% dexamethasone. (medicinenet.com)
- What is the most important information I should know about tobramycin and dexamethasone ophthalmic? (adventisthealthcare.com)
- Dexamethasone ophthalmic is used to treat the swelling associated with bacterial infections of the eye. (adventisthealthcare.com)
- Tobramycin and dexamethasone ophthalmic is used to treat bacterial infections of the eyes. (adventisthealthcare.com)
- Tobramycin and dexamethasone ophthalmic may also be used for purposes other than those listed in this medication guide. (adventisthealthcare.com)
- What should I discuss with my doctor before using tobramycin and dexamethasone ophthalmic? (adventisthealthcare.com)
- Do not use tobramycin and dexamethasone ophthalmic if you have a viral or fungal infection in the eye. (adventisthealthcare.com)
- It is not known whether tobramycin and dexamethasone ophthalmic will be harmful to an unborn baby. (adventisthealthcare.com)
- It is not known whether tobramycin and dexamethasone ophthalmic passes into breast milk. (adventisthealthcare.com)
- How should I use tobramycin and dexamethasone ophthalmic? (adventisthealthcare.com)
- Use tobramycin and dexamethasone ophthalmic eye drops or ointment exactly as directed by your doctor. (adventisthealthcare.com)
- Store tobramycin and dexamethasone ophthalmic at room temperature away from moisture and heat. (adventisthealthcare.com)
- What should I avoid while using tobramycin and dexamethasone ophthalmic? (adventisthealthcare.com)
- Tobramycin and dexamethasone ophthalmic may cause blurred vision. (adventisthealthcare.com)
- If you wear contact lenses, ask your doctor if you should wear them during treatment with tobramycin and dexamethasone ophthalmic. (adventisthealthcare.com)
Stop taking dexame2
- Dexamethasone sodium phosphate, a synthetic adrenocortical steroid, is a white or slightly yellow, crystalline powder. (nih.gov)
- Dexamethasone sodium phosphate injection, USP is a sterile solution of dexamethasone sodium phosphate, and is supplied in 4 mg/mL and 10 mg/mL. (nih.gov)
- Dexamethasone sodium phosphate injection, USP 4 mg/mL is a sterile solution for intravenous, intramuscular, intra-articular, intralesional and soft tissue administration. (nih.gov)
- Dexamethasone sodium phosphate 4.4 mg (equivalent to dexamethasone phosphate 4 mg). (nih.gov)
- Dexamethasone sodium phosphate 11 mg (equivalent to dexamethasone phosphate 10 mg). (nih.gov)
- Dexamethasone sodium phosphate injection has a rapid onset but short duration of action when compared with less soluble preparations. (nih.gov)
- American Regent is not marketing dexamethasone sodium phosphate injection at this time. (ashp.org)
- Fresenius Kabi has dexamethasone sodium phosphate on shortage due to increased demand. (ashp.org)
- AuroMedics has dexamethasone sodium phosphate 4 mg/mL 1 mL and 5 mL vials on long-term back order and the company cannot estimate a release date. (ashp.org)
- Fresenius Kabi has dexamethasone sodium phosphate short-dated 4 mg/mL 5 mL vials available with an expiration date of (ashp.org)
- Somerset Therapeutics has dexamethasone sodium phosphate 10 mg/mL vials on intermittent back order and the company is releasing product as it becomes available. (ashp.org)
- Dexamethasone Sodium Phosphate Injection - McKesson Medical-Surgical, Inc. (pattersondental.com)
- A formulation for preparing Granisetron HCl-Dexamethasone Sodium Phosphate Injection. (ijpc.com)
Amount of dexamethasone2
- The amount of dexamethasone you will receive depends on many factors, including your general health or other health problems, and the reason you are receiving this drug. (chemocare.com)
- The only difference between the low dose and high dose tests is the amount of dexamethasone that is injected. (vcahospitals.com)
Lenalidomide and dexamethasone3
- Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. (nih.gov)
- In this context, we prospectively evaluated the role of carfilzomib, lenalidomide and dexamethasone (KRd) as consolidation therapy post-ASCT in newly diagnosed MM pts who have not achieved MRD negative complete remission (CR). (myeloma.org)
- This is an open label, multicenter, exploratory, single arm, two-stage study aiming to explore efficacy and safety of lenalidomide and dexamethasone combination (LD) as first line therapy in previously untreated patients with primary Plasma Cell leukemia (PPCL). (clinicaltrials.gov)
Types of dexamethasone suppression tests2
- As a result of these actions and the initial work of early investigators (French & Galicich, 1964), glucocorticoids, specifically dexamethasone, are now routinely administered to brain tumor patients. (medscape.com)
- It is unclear whether dexamethasone in this condition is significantly better than other glucocorticoids. (wikipedia.org)
- Glucocorticoids, or steroids like dexamethasone, suppress the immune system and are used to stop the overreaction that can occur with arthritis, autoimmune diseases, and organ transplants. (medscape.com)
- People with cancer undergoing chemotherapy are often given dexamethasone to counteract certain side effects of their antitumor treatments. (wikipedia.org)
- You may be given dexamethasone as a lotion (topical) to treat skin disorders. (chemocare.com)
- Your doctor has weighed the risks of you being given DEXAMETHASONE MYLAN against the benefits they expect it will have for you. (news-medical.net)
- You should not be given DEXAMETHASONE MYLAN if you have an internal fungal infection or any other infection. (news-medical.net)
- You should not be given DEXAMETHASONE MYLAN if you have recently been given a live vaccine unless you are being given this medicine for replacement therapy. (news-medical.net)
- If you have not told your doctor about any of the above, tell them before you are given DEXAMETHASONE MYLAN. (news-medical.net)
- This is a [trial] result that shows that if patients who have COVID-19 and are on ventilators or are on oxygen are given dexamethasone, it will save lives, and it will do so at a remarkably low cost,' said Martin Landray, an Oxford University professor co-leading the trial, known as the RECOVERY trial. (abc.net.au)
- Patients with ulcerative colitis may benefit from dexamethasone therapy, as might those with exacerbations of multiple sclerosis . (encyclopedia.com)
- Dexamethasone is often prescribed to patients with cancer. (encyclopedia.com)
- Dexamethasone should be used cautiously in patients with kidney or liver problems, hypothyroidism, high blood pressure , or a history of heart attack . (encyclopedia.com)
- Oxford University's RECOVERY clinical trial has found that low-dose dexamethasone increases the chance of survival in patients with COVID-19 who require respiratory support. (medicalnewstoday.com)
- More than 40 years ago, dexamethasone was used in patients with brain tumors, and it is still used today. (medscape.com)
- However, pediatric patients are more likely to have slower growth and bone problems if dexamethasone is used for a long time. (mayoclinic.org)
- However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for elderly patients receiving dexamethasone. (mayoclinic.org)
- Nowadays evidence on the safety and efficacy of different dexamethasone in malignant brain tumor patients is still scarce and conflicting. (wikipedia.org)
- As part of his treatment for COVID-19, President Donald Trump began taking dexamethasone , a steroid that can help patients with severe forms of the disease. (medscape.com)
- A preliminary report about dexamethasone use in hospitalized COVID-19 patients showed that the drug lowered the chance of death for those who had supplemental oxygen or mechanical ventilation but not among those who didn't need respiratory support. (medscape.com)
- Overall, 482 of 2,104 patients, or 23%, who received dexamethasone died within 28 days, as compared with 26% of patients who received standard COVID-19 care but no steroids. (medscape.com)
- However, there was no evidence that dexamethasone provided any benefit among patients who were not receiving respiratory support," the authors wrote in TheNew England Journal of Medicine . (medscape.com)
- The goal of this clinical research study is to learn if dexamethasone can help reduce shortness of breath in cancer patients. (clinicaltrials.gov)
- As compared with MPT, continuous lenalidomide-dexamethasone given until disease progression was associated with a significant improvement in progression-free survival, with an overall survival benefit at the interim analysis, among patients with newly diagnosed multiple myeloma who were ineligible for stem-cell transplantation. (nih.gov)
- Adults with asthma who were treated with one-dose dexamethasone in the emergency department had only slightly higher relapse than patients who were treated with a 5-day course of prednisone. (medicalnewstoday.com)
- Of patients assigned to the dexamethasone group, 12.1 percent relapsed. (medicalnewstoday.com)
- For those patients and others like them, I might prefer to administer dexamethasone because it eliminates for them the burden of having to fill the prescription and remember to take it for the next four days. (medicalnewstoday.com)
- Researchers say a cheap and widely used steroid called dexamethasone has become the first drug to save the lives of COVID-19 patients in a 'major breakthrough' in the coronavirus pandemic. (abc.net.au)
- Among patients with COVID-19 who did not require respiratory support, there was no benefit from treatment with dexamethasone. (abc.net.au)
- News came yesterday from the Recovery trial effort in the UK that they had seen positive results from dexamethasone treatment in severely ill COVID-19 patients (news article from Science here ). (sciencemag.org)
- So here's what we have: 2104 patients, either on ventilation or receiving supplemental oxygen, were given 6mg dexamethasone (oral or i.v.) daily for ten days. (sciencemag.org)
- And the 28-day mortality for patients who needed no respiratory intervention, the 28-day mortality was 13%, and dexamethasone had no effect on that whatsoever. (sciencemag.org)
- In one study, researchers in the United Kingdom gave more than 2,100 patients dexamethasone (either orally or by injection) and compared their outcomes to patients receiving usual treatment. (medicaldaily.com)
- Hospitalized patients who received dexamethasone - a cheap, well-known drug - were more likely to survive than those who did not. (medicaldaily.com)
- The United Kingdom's Recovery study , which first revealed that dexamethasone could be helpful to COVID-19 patients, found "no evidence of benefit for patients who did not require oxygen. (yahoo.com)
- It was followed by a U.S. study that identified potential dangers of giving dexamethasone to patients who did not appear to be on the road to severe illness. (yahoo.com)
- A total of 258 patients with CSF culture-proven meningitis were enrolled between 1998 and 2002, before routine dexamethasone therapy was introduced, and 100 patients from March 2006 to January 2011, after guidelines recommended dexamethasone. (biomedsearch.com)
- The rate of arthritis was lower in patients treated with dexamethasone (32 of 258 [12%] vs 5 of 96 [5%], p = 0.046). (biomedsearch.com)
- CONCLUSIONS: Adjunctive dexamethasone is widely prescribed for patients with meningococcal meningitis and is not associated with harm. (biomedsearch.com)
- The World Health Organization called on Monday for a rapid increase in production of dexamethasone, a cheap steroid which has been shown to reduce deaths in critically ill coronavirus patients. (thejakartapost.com)
- The WHO emphasizes that dexamethasone should only be used for patients with severe or critical disease under close clinical supervision. (thejakartapost.com)
- This study will examine the potential efficacy of thalidomide-dexamethasone in the treatment of patients with previously untreated multiple myeloma. (knowcancer.com)
- For elderly patients, or those with poor performance status or comorbid conditions which may affect tolerance of the thalidomide-dexamethasone combination, the initial dose may be reduced by 50-100 mg decrements and escalated weekly by 50-100 mg increments to tolerance. (knowcancer.com)
- For patients achieving CR, consolidation with thalidomide-dexamethasone for 4-6 months followed by follow-up without maintenance treatment. (knowcancer.com)
- At relapse patients may be reinitiated on the original thalidomide-pulse dexamethasone program and responding patients may be maintained on thalidomide alone (CR) or daily thalidomide and dexamethasone (days 1-4) until relapse. (knowcancer.com)
- The primary aim was to determine the overall increase in the risk of ovarian cancer recurrence in these patients by determining tumor recurrence in women given perioperative dexamethasone versus those who did not receive the medication. (lww.com)
- This multicenter, phase 2 trial evaluated the efficacy and safety of weekly oral pomalidomide-cyclophosphamide-dexamethasone (PCD) in patients with MM in first relapse after treatment with lenalidomide-bortezomib-dexamethasone (RVD). (bloodjournal.org)
- All patients received pomalidomide-dexamethasone maintenance until disease progression. (bloodjournal.org)
- The dexamethasone study's results are preliminary, but the researchers behind the trial said it suggests the drug should become standard care in severely stricken patients. (theglobeandmail.com)
- Enrolled patients received lenalidomide at a dose of 25 mg/d for 21 days and oral dexamethasone at a dose of 40 mg on days 1, 8, 15, and 22 for each 28-day cycle. (clinicaltrials.gov)
- Before 1 April 2018, patients living with uveitis who are prescribed dexamethasone may have needed to pay over $2,700 per course for the treatment and management of the condition. (ranzco.edu)
- RANZCO advocated for the inclusion of dexamethasone onto the PBS, in order to allow uveitis patients access to a potentially vision-saving medication. (ranzco.edu)
- Currently, the drug dexamethasone is still the only therapeutic shown to be effective against the novel coronavirus for severe patients, the chief of the World Health Organization said Friday. (mercopress.com)
- Dexamethasone oral tablet is available as both a generic and brand-name drug. (medicalnewstoday.com)
- Dexamethasone oral tablet is used to treat many conditions. (medicalnewstoday.com)
- Oral tablet form dexamethasone is best taken with food, as it can irritate your stomach. (oncolink.org)
- Oral dexamethasone liquid should be mixed with other liquids like water, juices, or soda, or semi solid food like applesauce or pudding. (oncolink.org)
- Certain medications can interfere with this oral and liquid dexamethasone, so make sure your provider is aware of all the medications, vitamins and supplements you are taking. (oncolink.org)
- This formulation of dexamethasone does not cause the same side effects as the oral or liquid forms of this medication. (oncolink.org)
- Aerosolized racemic epinephrine as well as oral dexamethasone (a steroid) may be used to help shrink the upper airway swelling. (yourdictionary.com)
- Oral hydrocortisone is prescribed for younger children, and prednisone or dexamethasone is prescribed for older children. (yourdictionary.com)
- Venous blood sampling and biopsy of vastus lateralis were performed before and after administration of oral dexamethasone 4 mg/day for 4 days. (ingentaconnect.com)
- Before giving dexamethasone, tell your veterinarian if your pet is being given any other oral steroid medications such as prednisone, prednisOLOne, Methylprednisolone or others. (1800petmeds.com)
- Overnight suppression test: Administer 1 mg oral dexamethasone between 11 pm and midnight. (medscape.com)
- Standard 2-day dexamethasone suppression test: Administer 0.5 mg oral dexamethasone every 6 hours for 48 hours (9 am, 3 pm, 9 pm, and 3 am). (medscape.com)
- Acute and sub chronic effects of oral dexamethasone on anxiety and memory in mice were evaluated using the elevated plus maze, Y maze and radial arm maze. (scirp.org)
- The study concluded that oral dexamethasone given either acutely or sub chronically has both anxiogenic and memory enhancing effects. (scirp.org)
- Dexamethasone intravitreal steroid implants have been approved by the FDA to treat ocular conditions such as diabetic macular edema, central retinal vein occlusion, and uveitis. (wikipedia.org)
- Pravin U Dugel, Francesco Bandello, and Anat Loewenstein, "Dexamethasone intravitreal implant in the treatment of diabetic macular edema. (hindawi.com)
- Intravitreal dexamethasone implants are commonly used to treat macular edema and noninfectious uveitis, and side effects including glaucoma and cataract formation are frequently managed. (healio.com)
- However, this case shows peripheral retinal defects in a vitrectomized eye with abutting dexamethasone intravitreal implant without a flap, operculum, or other evidence of traction, developing 3 months after insertion, excluding the chance of injury from impact. (healio.com)
- The presence of an intravitreal dexamethasone implant appeared to cause destruction of juxtaposed retinal tissue. (healio.com)
- Juxtaposed to the holes was the remainder of an Ozurdex dexamethasone intravitreal implant, placed 3 months prior to this visit. (healio.com)
- The dexamethasone 0.7 mg sustained release intravitreal implant has been safely used to decrease macular edema in the setting of DME and retinal vein occlusion as well as treat noninfectious uveitis. (healio.com)
- Continuous lenalidomide-dexamethasone was superior to MPT for all secondary efficacy end points, including overall survival (at the interim analysis). (nih.gov)
- There are clear data to support that dexamethasone, with its relative low cost and high efficacy, is a preferred antiemetic for the prevention of PONV, as recommended by the PONV Consensus Guidelines. (lww.com)
- Dexamethasone and high dose metoclopramide: efficacy in controlling cisplatin induced nausea and vomiting. (bmj.com)
- When used to prevent or manage nausea or vomiting associated with chemotherapy, dexamethasone is given in the following dosages: 4-20 mg IV every 4-6 hours. (encyclopedia.com)
- Adverse effects, such as bone marrow suppression, are enhanced when dexamethasone is used with other immunosuppressants such as leflunomide ( Arava ) and tacrolimus ( Prograf ). (medicinenet.com)
- Dexamethasone suppression test measures the response of the adrenal glands to ACTH . (northside.com)
- What is the purpose of a dexamethasone suppression test? (vcahospitals.com)
- They are the "low dose" and the "high dose" dexamethasone suppression tests. (vcahospitals.com)
- The low dose dexamethasone suppression test can be used to screen for the presence of Cushing's disease and in many cases, it will determine the type of Cushing's disease that is present. (vcahospitals.com)
- Both the low dose and the high dose dexamethasone suppression tests take 8 hours to complete and involve three blood samples. (vcahospitals.com)
- What is the basis of the dexamethasone suppression tests? (vcahospitals.com)
- The dexamethasone suppression tests use the negative feedback mechanism in order to diagnose the presence of Cushing's disease. (vcahospitals.com)
- No, however, in most instances, the low dose dexamethasone suppression test will allow the diagnosis of Cushing's disease to be made and also gives an indication of the type of Cushing's disease (pituitary gland versus adrenal gland origin). (vcahospitals.com)
- A higher dosage of dexamethasone (high dose dexamethasone suppression test) may therefore be required to overcome this resistance and demonstrate the negative feedback mechanism. (vcahospitals.com)
- tell your doctor and pharmacist if you are allergic to dexamethasone, aspirin, tartrazine (a yellow dye in some processed foods and drugs), or any other drugs. (medlineplus.gov)
- Which drugs or supplements interact with dexamethasone-injectable? (medicinenet.com)
- Dexamethasone may decrease levels of drugs that are broken down by liver enzymes. (medicinenet.com)
- tell your doctor and pharmacist if you are allergic to dexamethasone, sulfites, or any other drugs. (medlineplus.gov)
- Dexamethasone belongs to a class of drugs called steroids. (medicalnewstoday.com)
- Dexamethasone is also used as a direct chemotherapeutic agent in certain hematological malignancies, especially in the treatment of multiple myeloma, in which dexamethasone is given alone or in combination with other chemotherapeutic drugs, including most commonly with thalidomide (Thal-dex), lenalidomide, bortezomib (Velcade, Vel-dex), or a combination of doxorubicin (Adriamycin) and vincristine or bortezomib/lenalidomide/dexamethasone. (wikipedia.org)
- After the announcement, several doctors expressed concerns about Trump moving back to the White House so soon after taking drugs like dexamethasone and remdesivir. (medscape.com)
- Before taking Dexamethasone, you should tell your doctor of any prescription or other drugs you may be using. (rebates.com)
- The below drugs and products may interact with dexamethasone. (rebates.com)
Hours for 48 hours1
- On day 2, you will get a low dose (0.5 mg) of dexamethasone by mouth every 6 hours for 48 hours. (northside.com)
Anti-inflammatory and immunosuppressant2
- Dexamethasone may cause side effects. (medlineplus.gov)
- What are the side effects of dexamethasone-injectable? (medicinenet.com)
- What are the side effects of tobramycin and dexamethasone? (medicinenet.com)
- Serious side effects can occur if you stop dexamethasone abruptly. (oncolink.org)
- There are a number of things you can do to manage the side effects of dexamethasone. (oncolink.org)
- Coronavirus: What is the 'breakthrough' treatment dexamethasone - and what are its side-effects? (carersuk.org)
- During the weekend, several doctors voiced concerns about dexamethasone use, including potential side effects on the heart, liver, and mind. (medscape.com)
- Dexamethasone is known to have mental health side effects. (medscape.com)
- This list includes common and less common side effects for individuals taking dexamethasone. (chemocare.com)
- Side effects of dexamethasone may include changes in appetite, increased thirst and urination, drowsiness, and hyperglycemia. (1800petmeds.com)
- Taking dexamethasone might induce side effects, and it is paramount that you tell your doctor immediately you see severe symptoms or side effects that do not go away. (rebates.com)
- Please contact your doctor or medical practitioner to understand more about the side effects of taking Dexamethasone Tablet 2mg. (chemistdirect.co.uk)
- Dexamethasone comes as a tablet and a solution to take by mouth. (medlineplus.gov)
- The dexamethasone tablet is available as the brand-name drug DexPak . (medicalnewstoday.com)
- Each tablet contains 1.5 mg of dexamethasone. (nih.gov)
- Dexamethasone comes as a tablet or liquid to be taken by mouth. (oncolink.org)
- Dexamethasone Tablets require a prescription from your veterinarian and are sold per tablet. (1800petmeds.com)
- Dexamethasone Tablet 2mg is a private prescription item. (chemistdirect.co.uk)
- If you require any help or assistance with purchasing Dexamethasone Tablet 2mg please contact our pharmacy team. (chemistdirect.co.uk)
Injection of dexamethasone2
- Vafaei, A.A., Rashidy-Pour, A. and Taherian, A.A. (2008) Peripheral Injection of Dexamethasone Modulates Anxiety Related Behaviors. (scirp.org)
- The first sample is taken prior to the injection of dexamethasone, and the second and third samples are taken at 4 and 8 hours following the dexamethasone injection. (vcahospitals.com)
- Au W-Y, Chan L-C, Liang R, Kwong Y-L.Myelodysplastic syndrome and acute myeloid leukemia after treatment with fludarabine, mitoxantrone, and dexamethasone. (springer.com)
- Early treatment with dexamethasone improves the outcome in adults with acute bacterial meningitis and does not increase the risk of gastrointestinal bleeding. (nih.gov)
- Dexamethasone has also been used with antibiotics to treat acute endophthalmitis. (wikipedia.org)
- Question: Is the adjunctive use of dexamethasone beneficial in the treatment of adults with acute bacterial meningitis? (cmaj.ca)
- Commentary: This is the first prospective clinical trial that strongly supports the use of dexamethasone in adults with acute bacterial meningitis, albeit in select circumstances. (cmaj.ca)
- Partial protection from acute silica toxicity by dexamethasone in rats. (cdc.gov)
- The Royal Australian and New Zealand College of Ophthalmologists is pleased with the announced introduction of dexamethasone (Ozurdex®) as a Pharmaceutical Benefits Scheme (PBS) authority prescription for non-infectious uveitis affecting the posterior segment. (ranzco.edu)
- Dexamethasone may commonly cause an increase in blood sugar , appetite, insomnia , acne , and nervousness or emotional instability ( depression or euphoria ). (medicinenet.com)
- medical citation needed] Dexamethasone is commonly given as a treatment for croup in children, as a single dose can reduce the swelling of the airway to improve breathing and reduce discomfort. (wikipedia.org)
- Dexamethasone is commonly used for treatment of nausea, tiredness, and pain. (clinicaltrials.gov)
- been found that the drug dexamethasone is a useful emergency first-aid treatment when injected into stricken climbers, allowing them to regain movement (when they might otherwise be incapacitated) and thus descend. (britannica.com)
- Dexamethasone 8 mg (2 capsules of 4 mg) given orally twice a day for 4 days, then 4 mg given orally twice a day for 3 days. (clinicaltrials.gov)
- Other protocols suggest starting dexamethasone 0.5 mg orally every 6 hours starting at noon for 48 hours and checking cortisol level 2 hours (8 am) after the last dose. (medscape.com)
- Do not use dexamethasone if the pet has a bacterial, viral, or fungal infection without also using proper anti-infective treatment. (1800petmeds.com)
- Besides C. deanei in dexamethasone-immunosuppressed mice provides a useful model for studies of monoxenous trypanosomatids 'in vivo' infection, resembling that one presumably occurring in imunodeficient individuals with AIDS. (scirp.org)
- Lallo, M.A., Santos, M.J. and Bondam, E.F. (2002) Experimenatal encephalitozoon cuniculi infection in dexamethasone-immunosuppressed mice. (scirp.org)
- The primary end point was progression-free survival with continuous lenalidomide-dexamethasone versus MPT. (nih.gov)
- When the FDA first noted the dexamethasone shortage in early 2019, no one had yet heard of SARS-CoV-2, the novel coronavirus that has since caused so much death, disability and global upheaval. (medicaldaily.com)
- A formulation for preparing Dexamethasone Phosphate 0.1% Topical Cream. (ijpc.com)
- Cortisol analogs, such as dexamethasone, are used to treat many inflammatory and rheumatic diseases, to suppress the immune response in allergies and in organ transplantation, and to delay the progress of leukemia. (britannica.com)
- Live vaccines should also be avoided because dexamethasone reduces immune function. (medicinenet.com)
- The results of our review may not apply to participants at risk of dexamethasone-related adverse events for whom clinical trials would probably be unsafe. (cochrane.org)
- Dexamethasone was not associated with adverse events. (biomedsearch.com)
- However, reports of retinal impact defects, macular hole formation, injection into the crystalline lens or into the subretinal space represent serious, though rare, previously reported adverse events (AEs) for the dexamethasone implant. (healio.com)
- The typical quantity present in a lead tip is less than 1.0 mg.[medical citation needed] Dexamethasone may be administered before antibiotics in cases of bacterial meningitis. (wikipedia.org)
- De Gans J, van de Beek D, for the European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators. (cmaj.ca)
- To determine whether treatment with dexamethasone and ceftriaxone for children with bacterial meningitis reduces the frequency of either sensorineural hearing loss or other neurologic sequelae. (aappublications.org)
- Dexamethasone did not significantly improve audiologic, neurologic, or developmental outcome in children with bacterial meningitis. (aappublications.org)
- Does early administration of dexamethasone improve neurological outcome in children with meningococcal meningitis? (yourdictionary.com)
- CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that adjuvant dexamethasone in adults with meningococcal meningitis does not increase negative outcomes such as deafness, death, or negative Glasgow Outcome Scale measures. (biomedsearch.com)
- A formulation for preparing Dexamethasone and Lidocaine Solution for Iontophoresis. (ijpc.com)
- Low-dose overnight method -- you will get 1 mg of dexamethasone at 11 p.m., and a health care provider will draw your blood at 8 a.m. for a cortisol measurement . (northside.com)
- Dexamethasone is a human-made (synthetic) steroid that is similar to cortisol. (northside.com)
- Therefore, taking dexamethasone should reduce ACTH levels and lead to decreased cortisol levels. (northside.com)
- Two tests use dexamethasone (a synthetic cortisol) for diagnosing hyperadrenocorticism (Cushing's disease or Cushing's syndrome). (vcahospitals.com)
- When healthy dogs are given an injection of synthetic cortisol (dexamethasone) the level of ACTH is suppressed, causing a decrease in cortisol levels in the blood for a period of time. (vcahospitals.com)
- Blood samples are taken at 4- and 8-hours following dexamethasone injection, and the amount of cortisol in each of the samples is measured and compared. (vcahospitals.com)
Treatment for COVID-191
- Despite persistent and ongoing shortages, President Trump received dexamethasone while undergoing treatment for COVID-19 in early October. (medicaldaily.com)