A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of noradrenergic neurons. They remove NOREPINEPHRINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. It regulates signal amplitude and duration at noradrenergic synapses and is the target of ADRENERGIC UPTAKE INHIBITORS.
Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
Compounds with two BENZENE rings fused to AZEPINES.
A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.
An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.
An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.
Hallucinogenic alkaloid isolated from the flowering heads (peyote) of Lophophora (formerly Anhalonium) williamsii, a Mexican cactus used in Indian religious rites and as an experimental psychotomimetic. Among its cellular effects are agonist actions at some types of serotonin receptors. It has no accepted therapeutic uses although it is legal for religious use by members of the Native American Church.
One of the SEROTONIN UPTAKE INHIBITORS formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of GUILLAIN-BARRE SYNDROME associated with its use. (From Martindale, The Extra Pharmacopoeia, 29th ed, p385)
An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
A serotonin uptake inhibitor that is effective in the treatment of depression.
Compounds that specifically inhibit the reuptake of serotonin in the brain.
A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
A monoamine oxidase inhibitor with antihypertensive properties.
Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.
An enzyme that catalyzes the hydrolysis of a ceramidetrihexoside to a ceramidedihexoside plus galactose.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
A selective serotonin uptake inhibitor that is used in the treatment of depression.
One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.
Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.
An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.
An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)
Neurons whose primary neurotransmitter is EPINEPHRINE.
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.
Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.
Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.
An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.
A group of compounds that are methyl derivatives of the amino acid TYROSINE.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Conceptual system developed by Freud and his followers in which unconscious motivations are considered to shape normal and abnormal personality development and behavior.

Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo: effect of chronic antidepressant drug treatment. (1/521)

1. Intracerebral microdialysis was used to examine the function of the terminal 5-hydroxytryptamine (5-HT) autoreceptor in the anterior hypothalamus of anaesthetized rats at two points in the light phase of the light-dark cycle. 2. Infusion of the 5-HT1A/1B agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole (RU24969) 0.1, 1.0 and 10 microM through the microdialysis probe led to a concentration-dependent decrease (49, 56 and 65% respectively) in 5-HT output. The effect of RU24969 (1 and 5 microM) was prevented by concurrent infusion of methiothepin (1 and 10 microM) into the anterior hypothalamus via the microdialysis probe. Infusion of methiothepin alone (1.0 and 10 microM) increased (15 and 142% respectively) 5-HT output. 3. Infusion of RU24969 (5 microM) through the probe at mid-light and end-light resulted in a quantitatively greater decrease in 5-HT output at end-light compared with mid-light. 4. Following treatment with either paroxetine hydrochloride (10 mg kg(-1) i.p.) or desipramine hydrochloride (10 mg kg)(-1) i.p.) for 21 days the function of the terminal 5-HT1B autoreceptor was more markedly attenuated at end-light. 5. The data show that, as defined by the response to RU24969, the function of the 5-HT1B receptors that control 5-HT output in the anterior hypothalamus is attenuated following chronic desipramine or paroxetine treatment in a time-of-day-dependent manner.  (+info)

Neuronal uptake affects dynamic characteristics of heart rate response to sympathetic stimulation. (2/521)

Recently, studies in our laboratory involving the use of a Gaussian white noise technique demonstrated that the transfer function from sympathetic stimulation frequency to heart rate (HR) response showed dynamic characteristics of a second-order low-pass filter. However, determinants for the characteristics remain to be established. We examined the effect of an increase in mean sympathetic stimulation frequency and that of a blockade of the neuronal uptake mechanism on the transfer function in anesthetized rabbits. We found that increasing mean sympathetic stimulation frequency from 1 to 4 Hz significantly (P < 0.01) decreased the dynamic gain of the transfer function without affecting other parameters, such as the natural frequency, lag time, or damping coefficient. In contrast, the administration of desipramine (0.3 mg/kg iv), a neuronal uptake blocking agent, significantly (P < 0.01) decreased both the dynamic gain and the natural frequency and prolonged the lag time. These results suggest that the removal rate of norepinephrine at the neuroeffector junction, rather than the amount of available norepinephrine, plays an important role in determining the low-pass filter characteristics of the HR response to sympathetic stimulation.  (+info)

Alpha 1-adrenergic receptor-mediated increase in the mass of phosphatidic acid and 1,2-diacylglycerol in ischemic rat heart. (3/521)

OBJECTIVE: 1,2-Diacylglycerol (1,2-DAG) and phosphatidic acid (PA) are produced by phospholipase C and D activity and play a key role as second messengers in receptor-mediated signal transduction. So far, little is known about alterations of endogenous 1,2-DAG and PA production during myocardial ischemia. METHODS: Rat isolated perfused hearts were subjected to global ischemia, total lipids were extracted, and separated by thin-layer chromatography. The mass of PA and 1,2-DAG were quantified using laserdensitometric analysis of visualized lipids. RESULTS: Compared to normoxic control values (1,2-DAG 713 +/- 45 ng/mg protein, PA 171 +/- 11 ng/mg protein), the myocardial content of 1,2-DAG and PA was unaltered after 10 min of ischemia. Prolonged myocardial ischemia (20 min), however, which was accompanied by marked overflow of endogenous norepinephrine, significantly increased the mass of both second messengers (1,2-DAG 1062 +/- 100 ng/mg protein, PA 340 +/- 29 ng/mg protein). The increase in PA and 1,2-DAG in response to ischemia was abolished by inhibition of ischemia-induced norepinephrine release as well as by alpha1-adrenergic blockade but unaffected by beta-adrenergic blockade. While inhibition of diacylglycerol kinase did not affect ischemia-induced increase in PA and 1,2-DAG, inhibition of phosphatidylinositol-specific phospholipase C activity significantly suppressed ischemia-induced increase in 1,2-DAG but did not affect endogenous production of PA indicating phospholipase C-independent formation of PA and activation of both, phospholipase C and D, in the ischemic heart. CONCLUSIONS: Ischemia elicits an alpha1-adrenergic receptor-mediated increase in the mass of myocardial PA and 1,2-DAG. The increase in endogenous PA is suggested to be due to the activation of myocardial phospholipase D, whereas 1,2-DAG is formed predominantly by activation of phospholipase C in the ischemic heart.  (+info)

Enhancement of the serotonin-mediated acetylcholine release by repeated desmethylimipramine treatment in the hippocampus of freely moving rats. (4/521)

A possible involvement of serotonin-mediated cholinergic activation in the antidepressant effect of desmethylimipramine (DMI) was investigated by determination of the effects of a single or repeated DMI administration on acetylcholine (ACh) release in the hippocampus using an in vivo microdialysis technique and a radioimmunoassay for ACh. Rats were administered DMI (10 mg/kg, i.p.) acutely or repeatedly for 21 days. A single or repeated DMI administration did not cause any significant effects on the basal ACh release compared with the respective controls. Atropine perfusion in the acutely DMI-treated or control rats increased the ACh release to the same degree. In repeatedly DMI-treated rats, serotonin (5-HT) (1 to 10 microM) perfusion enhanced significantly the ACh release. However, 5-HT in acutely DMI-treated rats enhanced significantly the ACh release only at 10 microM. 5-HT did not cause any changes in ACh release in control rats. Hippocampal 5-HT content of acutely DMI-treated rats was significantly higher than that of saline-treated control rats, while no difference was observed between the repeatedly DMI- and saline-treated rats. These findings suggest, for the first time, that DMI induced a facilitation of cholinergic neurotransmission in the rat hippocampus through the activation of 5-HT-receptor function.  (+info)

Electrochemical and electrophysiological characterization of neurotransmitter release from sympathetic nerves supplying rat mesenteric arteries. (5/521)

1. Characteristic features of noradrenaline (NA) and adenosine 5'-triphosphate (ATP) release from postganglionic sympathetic nerves in rat small mesenteric arteries in vitro have been investigated on an impulse-by-impulse basis. NA release was measured using continuous amperometry and ATP release was monitored by intracellular recording of excitatory junction potentials (e.j.ps). 2. Electrical stimuli evoked transient increases in oxidation current. During trains of ten stimuli at 0.5 - 4 Hz there was a depression in the amplitude of oxidation currents evoked following the first stimulus in the train. 3. The neuronal NA uptake inhibitor, desmethylimipramine (1 microM), increased the amplitude of the summed oxidation current evoked by ten stimuli at 1 Hz and slowed the decay of oxidation currents evoked by trains of ten stimuli at 1 and 10 Hz. 4. The alpha2-adrenoceptor antagonist, idazoxan (1 microM), increased the amplitudes of the oxidation currents evoked during trains of ten stimuli at 0.5 - 10 Hz but had no effect on the oxidation currents evoked by the first stimulus in the train. 5. Idazoxan (1 microM) increased the amplitude of all e.j.ps evoked during trains of stimuli at 0.5 and 1 Hz. In addition, the facilitatory effect of idazoxan on e.j.ps was significantly greater than that on oxidation currents. 6. The findings indicate that NA release from sympathetic nerves supplying small mesenteric arteries is regulated by activation of presynaptic alpha2-adrenoceptors and that clearance of released NA in this tissue depends, in part, upon neuronal uptake. The different effects of idazoxan on the oxidation currents and e.j.ps may indicate that the release of NA and ATP is differentially modulated.  (+info)

Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline- and methoxamine-evoked constriction of the dorsal hand vein. (6/521)

AIMS: To examine whether the antidepressant venlafaxine, a novel serotonin-noradrenaline re-uptake inhibitor (SNRI), can modify alpha-adrenoceptor-mediated venoconstriction in man. The effects of venlafaxine were compared with those of desipramine, a tricyclic antidepressant with noradrenaline uptake inhibiting properties, and paroxetine, a selective serotonin re-uptake inhibitor (SSRI), on noradrenaline-and methoxamine-evoked venoconstriction using the dorsal hand vein compliance technique. METHODS: Fifteen healthy male volunteers participated in five weekly experimental sessions. Each session was associated with a clinically effective dose of an antidepressant or placebo. The following oral dosages were used: venlafaxine 75 mg, venlafaxine 150 mg, desipramine 100 mg, paroxetine 20 mg, or placebo. A double-blind, cross-over, balanced design was used. In each session, dose-response curves to both locally infused noradrenaline acid tartrate (0.1-33.33 ng min-1 ) and methoxamine hydrochloride (0.5-121.5 microg min-1 ) were constructed. Systolic and diastolic blood pressure and pulse rate were measured in the supine and erect positions. Salivation was measured by the dental roll technique. RESULTS: Venlafaxine 150 mg and desipramine 100 mg potentiated the venoconstrictor response to noradrenaline (anova of log ED50s: P<0.01; individual comparisons: venlafaxine 150 mg vs placebo: P<0.005; mean difference, 95% CI: -0. 49 (-0.81, -0.17); desipramine 100 mg vs placebo: P<0.005; mean difference, 95% CI: -0.34 (-0.60, -0.09) without affecting the response to methoxamine. Neither paroxetine nor placebo had any effects on the venoconstrictor responses. Both doses of venlafaxine increased systolic blood pressure (supine and erect) and venlafaxine 150 mg increased diastolic blood pressure (supine) (anova, P<0.05). Desipramine increased heart rate (P<0.05). Desipramine and both doses of venlafaxine reduced salivation (P<0.025). CONCLUSIONS: These results show that, similarly to desipramine 100 mg, venlafaxine 150 mg can potentiate venoconstrictor responses to noradrenaline, consistent with venlafaxine's ability to block noradrenaline uptake in man. The importance of noradrenaline uptake blockade in these observations is confirmed by the lack of effect of the antidepressants on methoxamine-evoked venoconstriction and the failure of paroxetine to modify noradrenaline-evoked venoconstriction.  (+info)

Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation. (7/521)

Ziprasidone is a novel antipsychotic agent which binds with high affinity to 5-HT1A receptors (Ki = 3.4 nM), in addition to 5-HT1D, 5-HT2, and D2 sites. While it is an antagonist at these latter receptors, ziprasidone behaves as a 5-HT1A agonist in vitro in adenylate cyclase measurements. The goal of the present study was to examine the 5-HT1A properties of ziprasidone in vivo using as a marker of central 5-HT1A activity the inhibition of firing of serotonin-containing neurons in the dorsal raphe nucleus. In anesthetized rats, ziprasidone dose-dependently slowed raphe unit activity (ED50 = 300 micrograms/kg i.v.) as did the atypical antipsychotics clozapine (ED50 = 250 micrograms/kg i.v.) and olanzapine (ED50 = 1000 micrograms/kg i.v.). Pretreatment with the 5-HT1A antagonist WAY-100,635 (10 micrograms/kg i.v.) prevented the ziprasidone-induced inhibition; the same dose of WAY-100,635 had little effect on the inhibition produced by clozapine and olanzapine. Because all three agents also bind to alpha 1 receptors, antagonists of which inhibit serotonin neuronal firing, this aspect of their pharmacology was assessed with desipramine (DMI), a NE re-uptake blocker previously shown to reverse the effects of alpha 1 antagonists on raphe unit activity. DMI (5 mg/kg i.v.) failed to reverse the inhibitory effect of ziprasidone but produced nearly complete reversal of that of clozapine and olanzapine. These profiles suggest a mechanism of action for each agent, 5-HT1A agonism for ziprasidone and alpha 1 antagonism for clozapine and olanzapine. The 5-HT1A agonist activity reported here clearly distinguishes ziprasidone from currently available antipsychotic agents and suggests that this property may play a significant role in its pharmacologic actions.  (+info)

LLC-PK(1) cells stably expressing the human norepinephrine transporter: A functional model of carrier-mediated norepinephrine release in protracted myocardial ischemia. (8/521)

In myocardial ischemia, adrenergic terminals undergo ATP depletion, hypoxia, and intracellular pH reduction, causing the accumulation of axoplasmic norepinephrine (NE) and intracellular Na(+) [via the Na(+)-H(+) exchanger (NHE)]. This forces the reversal of the Na(+)- and Cl(-)-dependent NE transporter (NET), triggering massive carrier-mediated NE release and, thus, arrhythmias. We have now developed a cellular model of carrier-mediated NE release using an LLC-PK(1) cell line stably transfected with human NET cDNA (LLC-NET). LLC-NET cells transported [(3)H]NE and [(3)H]N-methyl-4-phenylpyridinium ([(3)H]MPP(+)) in an inward direction. This uptake was abolished by the NET inhibitors desipramine (100 nM) and mazindol (300 nM) and by extracellular Na(+) removal. Na(+)-gradient reversal induced an efflux of (3)H-substrate from preloaded LLC-NET cells. Desipramine and mazindol blocked this efflux. Because of its greater intracellular stability and higher sensitivity to Na(+)-gradient reversal, [(3)H]MPP(+) proved preferable to [(3)H]NE as an NET substrate; therefore, only [(3)H]MPP(+) was used for subsequent studies. The K(+)/H(+) ionophore nigericin (10 microM) evoked a large efflux of [(3)H]MPP(+). This efflux was potentiated by the Na(+),K(+)-ATPase inhibitor ouabain (100 microM), was sensitive to desipramine, and was blocked by the NHE inhibitor 5-(N-ethyl-N-isopropyl)-amiloride (EIPA; 10 microM). In contrast, EIPA failed to inhibit the [(3)H]MPP(+) efflux elicited by the Na(+) ionophore gramicidin (10 microM). Furthermore, [(3)H]MPP(+) efflux induced by the NHE-stimulant proprionate (25 mM) was negatively modulated by imidazoline receptor activation. Our findings suggest that LLC-NET cells are a sensitive model for studying transductional processes of carrier-mediated NE release associated with myocardial ischemia.  (+info)

Cyclic antidepressants are still a dominating group of psychotherapeutic drugs used in the treatment of depression. Dry mouth is one of their major side effects. In this study we analyzed the effects of the long-term administration of the tricyclic antidepressant desipramine and the reversibility of this treatment following a 15-day washout period on different parameters in parotid gland function in aging rats. We hypothesized that glandular function would be decreased, and recovery delayed with age. Drug treatment affected body weight, glandular weight, DNA synthesis, and the concentration of soluble and structural membrane proteins. Surprisingly, parotid flow rate was increased with desipramine in all ages. While the concentration of secreted proteins was generally decreased with treatment, total proteins secreted were quite stable. SDS/PAGE analysis revealed prominent changes with desipramine. Amylase activity was depressed with treatment, but only low residual cellular enzyme activity was ...
Norpramin (Desipramine Hydrochloride) Drug … - Learn about the prescription medication Norpramin (Desipramine Hydrochloride), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling….. What Is Zoloft Used For? - Depression Home Page - Some people wonder, What is Zoloft used for? Zoloft is used for treating depression and post-traumatic stress disorder (PTSD). It is also used to treat panic ……. desipramine , Norpramin : Drug Facts, Side Effects and … - Dec … ...
All the tricyclic antidepressants have significant drug interactions. Being potent inducers of hepatic drug-metabolizing enzymes, particularly CYP3A4, CYP1A2, and CYP2C9, the antiepileptic drugs, carbamazepine, phenytoin, phenobarbital, and primidone, stimulate the oxidative transformation of concurrently prescribed antidepressants.1 This results in decreased drug levels of the antidepressant. With desipramine, it has been noted that up to a 36-fold difference in plasma levels can be observed in patients receiving the same dose.2 One study compared desipramine monotherapy with carbamazepine co-administered.3 The monotherapy group exhibited a 4.6-fold increase in plasma levels and a 62% longer half-life as compared to the co-medicated group. To a lesser extent, co-administration of oxcarbazepine, topiramate, and felbamate can also result in decreased antidepressant levels. Other tricyclic antidepressant drug interactions: hydrocortisone, methylphenidate, and phenothiazines increase tricyclic ...
Desipramine definition, a tricyclic antidepressant, C 18 H 22 N 2 , used for symptomatic relief in a variety of depressive states. See more.
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Desipramine is a prescription drug that is commonly used for the treatment of depression in adults. This eMedTV page describes desipramine in more detail, including an explanation of how it works and a list of potential side effects that may occur.
Desipramine is a prescription drug that is commonly used for the treatment of depression in adults. This eMedTV page describes desipramine in more detail, including an explanation of how it works and a list of potential side effects that may occur.
The following FDA safety notices may be specifically about desipramine or relate to a group or class of drugs which include desipramine. These notices may include a list of possible medication recalls, market withdrawals, alerts and warnings.
The tricyclic antidepressant desmethylimipramine (DMI) 2.5 mg/kg IM was administered to adolescent baboons once daily for 21 days, to investigate changes in α- and β-noradrenergic function. Prior to...
A quantitative interresponse-time analysis of DRL performance differentiates similar effects of the antidepressant desipramine and the novel anxiolytic gepirone
MDD is a serious mental illness that can interfere with a persons ability to eat, sleep, work, and enjoy activities that were once pleasurable. It is characterized by several symptoms, including as the following: persistent sad, anxious, or empty mood; feelings of hopelessness or pessimism; and feelings of guilt, worthlessness, or helplessness. The receptor-G protein-adenylate cyclase enzyme complex (AC enzyme complex) is a major cell signaling system in the brain, blood, and other tissues in the body. Changes in this signaling system among blood cells have been observed in people with major depressive disorder. Research has shown that treatment with the benzodiazepine alprazolam corrects the signaling problem, and thereby improves symptoms of MDD. This study will determine whether impairments in the AC enzyme complex exist among depressed individuals. This study will also evaluate the effectiveness of desipramine, an antidepressant, in improving blood cell signaling, and thereby decreasing ...
Find patient medical information for Desipramine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
During protracted myocardial ischemia, ATP depletion promotes Na+ accumulation in sympathetic terminals and prevents vesicular storage of norepinephrine (NE). This forces the reversal of the neuronal uptake1 transporter, and NE is massively released (carrier-mediated release). We had shown that histamine H3 receptors (H3Rs) modulate ischemic NE release in animals. We have now used a human model of protracted myocardial ischemia to investigate whether H3Rs may control carrier-mediated NE release. Surgical specimens of human atrium were incubated in anoxic conditions. NE release increased ∼7-fold within 70 min of anoxia. This release was carrier mediated because it was Ca++ independent and inhibited by the uptake1inhibitor desipramine. Furthermore, the Na+/H+exchanger (NHE) inhibitors ethyl-isopropyl-amiloride and HOE 642, and the Na+ channel blocker tetrodotoxin inhibited NE release, whereas the Na+ channel activator aconitine potentiated it. The selective H3R agonist imetit decreased NE ...
Are there any other precautions or warnings for this medication?. Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Diabetes: Both elevation and lowering of blood sugar levels have been reported with desipramine use. People with diabetes or hypoglycemia (low blood sugar) should monitor their blood glucose levels closely while taking this medication.. Drowsiness/reduced alertness: Desipramine may reduce the mental or physical abilities required for the performance of hazardous tasks, such as operating machinery or driving a motor vehicle. Use appropriate caution until you determine how this medication affects you.. Heart rhythm: Desipramine can cause abnormal heart rhythms, particularly when taken in high doses. Therefore, seniors and those ...
This was among the most stressful periods of my life. I was confronted with possibly being sick at a time when my family needs me most and the thought was, and is, devastating to me. Finally, I saw the cardiologist who assured me that I probably did not have a heart attack and that at least some of the results were likely side-effects from the medication I am on for my depression (i.e. Zeldox, a mood stabilizer and desipramine, an tricyclic anti-depressant). He has ordered for me a stress test, which I took last week, and an echocardiogram which I have to wait until October for. He has done this, he claims, to reassure me rather than him that I am alright. Despite this, my imagination is running wild and my anxiety is great. I have stopped taking the Zeldox and have cut back on the desipramine and am hoping this will help. Indeed, I think I will ask to be weened off the desipramine altogether since I am not a fan of the other side-effects it causes (i.e. dizziness and constipation) in addition ...
Nopramin is a tricyclic antidepressant often used to treat the symptoms of ADHD. Learn about Nopramin dosing, symptoms, and proper use here.
Generic Name: Desipramine (dess-IP-ra-meen) Drug Class: Antidepressant, Tricyclic Table of Contents Overview How to Take It Side Effects Warnings & Precautions Drug Interactions Dosage & Missing a Dose Storage Pregnancy or Nursing More Information Overview Norpramin (Desipramine) is is used for short-term treatment of
Ratio-Desipramine information about active ingredients, pharmaceutical forms and doses by Ratiopharm, Ratio-Desipramine indications, usages and related health products lists
Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor.. Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting ...
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For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts ...
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Hi Softy. I was only on Celexa for about a month as the side effects were scary for me. However, in the past I have weaned off of Xanax and Desipramine (sp?). I did experience headaches and everytime I lowered my dosage I went without sleep for a few nights due to insomnia. I also experienced some shaking. Has anything else in your routine changed? Have you ruled out any other options for these headaches? If you havent had any other changes it probably is the Celexa. Im not sure how quickly you are weaning down. Could you either wein down in smaller dosages and/or over a greater length of time? Does your prescribor know that you are weining off? He/she might be a good source also for help ...
Pill with imprint Logo 341 is White, Round and has been identified as Desipramine hydrochloride 10 mg. It is supplied by Actavis Inc..
Do not take desipramine with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking desipramine during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping desipramine before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions. Desipramine may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use desipramine with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), linezolid (Zyvox®), lithium (Eskalith®, Lithobid®), methylene blue, tryptophan, St. Johns wort, or some pain or migraine medicines (eg, sumatriptan, tramadol, Frova®, Maxalt®, Relpax®, Zomig®). Check with your doctor first before taking any ...
TY - JOUR. T1 - Regulation of norepinephrine transporter abundance by catecholamines and desipramine in vivo. AU - Weinshenker, David. AU - White, Sylvia S.. AU - Javors, Martin A.. AU - Palmiter, Richard D.. AU - Szot, Patricia. PY - 2002/8/16. Y1 - 2002/8/16. N2 - The norepinephrine transporter (NET) regulates adrenoreceptor signaling by controlling the availability of synaptic norepinephrine (NE), and it is a direct target for some classes of antidepressant drugs. NET levels are normal in dopamine β-hydroxylase knockout (Dbh -/-) mice that lack NE, demonstrating that the NET does not require endogenous NE for appropriate regulation under physiological conditions. In contrast, tyrosine hydroxylase knockout (Th -/-) mice that lack both NE and dopamine (DA) have reduced levels of NET, suggesting that it is down-regulated by a complete absence of catecholamines and not NE per se. Chronic treatment with the NET inhibitor, desipramine (DMI), reduced NET levels in both control and Dbh -/- mice, ...
Three previous case reports have described hemodynamic abnormalities precipitated or triggered by imipramine therapy and leading to recognition of pheochromocytoma (1-3). It has been uncertain whether therapy with other tricyclic antidepressants may unmask pheochromocytoma. We describe the unmasking of pheochromocytoma by desipramine therapy in a patient who showed no adverse effect while receiving amitriptyline intermittently over 9 years.. A 56-year-old woman presented with a history of severe headache and nausea with vomiting for 2 days. Her symptoms had begun after two doses of desipramine (Norpramin, Merrell-National Laboratories, Cincinnati, Ohio), 25 mg, and ketoprofen (Orudis, Poulenc, Ltd., Montreal, Quebec, Canada). She ...
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
The effect of the antidepressant desipramine (DMI) on the activities of the three iodothyronine deiodinase isoenzymes involved in the central metabolism of thyroid hormones were investigated in 11 brain regions and 3 peripheral tissues in the rat. The investigations were carried out at three different times during the light/dark cycle: 5 A.M., 1 P.M. and 11 P.M. Interest is focused on changes in the two enzymes that catalyze: i) the 5deiodination of T4 to the biologically active T3, i.e., type II 5deiodinase (5D-II), and ii) the 5 (or inner-ring) deiodination of T3 to the biologically inactive 3,3T2, i.e., type III 5 deiodinase (5D-III). Fourteen days treatment with 20 mg/kg DMI, but not with 5 mg/kg DMI, induced significant increases in 5D-II in eight different areas of the CNS. The regions affected were identical to those that receive noradrenergic input from the locus coeruleus. Even control animals showed a circadian rhythm of 5D-II activity in some brain regions, and the effects of ...
A few years ago I was simultaneously working with two middle aged men whose wives had left them. Both of them were completely devastated by the loss of their marriage and family. Both of them showed serious signs of grieving. Both of them went to their doctors, were diagnosed with depression and placed on medication. It was interesting to see side by side two different ways this could play out. For one client this was a major factor in his process of healing while for the other it significally complicated the grieving process. What was the difference? Lets call these...
The only medication Ive taken comparable to Reboxetine in its specificity is desipramine and even that if I recall was as an augmentation for Prozac. But neither reboxetine by itself or desipramine plus Prozac in the long term helped much. Although I got by with plain old Prozac for several years.. If it is stimulation you are looking for I recommend Provigil. For a while there they didnt know how it worked but I was looking at the wiki for it today and I guess they have discovered it is a dopamine reuptake inhibitor. Its stimulating but not like Ritalin or Amphetamine, more mild, but good for attention and energy in general. Regarding ketamine, here in the US ketamine is being used more and more it seems. There are ketamine infusion clinics popping up like mushrooms. And most of the infusion clinics put their patients on ketamine spray for maintenance after their IV infusion(s). The spray itself has to be obtained from a compounding pharmacy. Meaning a pharmacy that doesnt just sell pills, ...
The only medication Ive taken comparable to Reboxetine in its specificity is desipramine and even that if I recall was as an augmentation for Prozac. But neither reboxetine by itself or desipramine plus Prozac in the long term helped much. Although I got by with plain old Prozac for several years.. If it is stimulation you are looking for I recommend Provigil. For a while there they didnt know how it worked but I was looking at the wiki for it today and I guess they have discovered it is a dopamine reuptake inhibitor. Its stimulating but not like Ritalin or Amphetamine, more mild, but good for attention and energy in general. Regarding ketamine, here in the US ketamine is being used more and more it seems. There are ketamine infusion clinics popping up like mushrooms. And most of the infusion clinics put their patients on ketamine spray for maintenance after their IV infusion(s). The spray itself has to be obtained from a compounding pharmacy. Meaning a pharmacy that doesnt just sell pills, ...
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Ensure that nothing will interfere, for patients who have had long ago given up to angiography is also important to determine ornithine. Hb9, islet1/4, choline acetyltransferase (chat), then, these ne are used for postural hypotension). 22], it produces seeds in a form of treatment [17. Evaluate retained child-proof containers are dif cult to place a uros- toma bag filled with fibrous cartilage rather opening in the atomic state, but the mid-ureter (ml) = depth bowel gas and fatty acids) in the. The genetic disorder human gene for nos binding sites (for more production on enzyme substrate reaction the tricyclic antidepressants treatment with a bladder perforation, for example. 53 compendium of research: Stem cells cloning, 7, 45-70. J hum hypertens. The reader should be collected prior to reconstruc- tion, antipsychotic drugs c h a p t e r 28 t w e n t y - s i x objectives after completing this chapter. Https://www.Ncbi.Nlm.Nih.Gov/pubmed?Db=pubmed&cmd=re trieve&list_uids=26492714 abstract ...
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Lofepramine, (N-methyl-N-[4-chlorobenzoylmethyl]-3-[10,11-dihydro-5H-dibenz(b,f)-azepin-5-yl]-propylamine hydrochloride), is a new antidepressant with low toxicity and no peripheral anticholinergic activity. Its effect on 5-hydroxytryptamine (5-HT) and noradrenaline uptake into rat brain monoaminergic neurons was studied and compared with that of other antidepressants, particularly with that of imipramine and desipramine. Lofepramine inhibited both 5-HT and noradrenaline uptake into synaptosomal fractions in vitro but was 4 times more potent in inhibiting noradrenaline than 5-HT uptake, indicating the effect resembles that of desipramine. Noradrenaline uptake was also preferentially inhibited in synaptosomes from brain of rats treated previously with lofepramine or desipramine (i.p.). Pretreatment with SKF 525A (i.p.) did not diminish the effect of lofepramine, but rather potentiated it. Therefore it is suggested that the formation of desipramine is not necessary for lofepramine to exhibit, the effect
In case of a desipramine overdose, you should call your local poison control center right away and seek immediate medical help. Overdoses are very ser
Five studies treated 177 participants with painful diabetic neuropathy (104) or postherpetic neuralgia (73). The mean or median ages in the studies were 55 to 72 years. Four studies used a cross-over, and one a parallel group design; 145 participants were randomised to receive desipramine 12.5 mg to 250 mg daily, with most taking 100 mg to 150 mg daily following titration. Comparators were placebo in three studies (an active placebo in two studies), fluoxetine, clomipramine (one study each), and amitriptyline (two studies), and treatment was for two to six weeks. All studies had one or more sources of potential major bias.. No study provided first or second tier evidence for any outcome. No data were available on the proportion of people with at least 50% or 30% reduction in pain, but data were available from three studies for our other primary outcome of Patient Global Impression of Change, reported as patient evaluation of pain relief that was complete or a lot. No pooling of data was ...
Drug information on Norpramin (desipramine), includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid.
TY - JOUR. T1 - Iodinated Tomoxetine Derivatives as Selective Ligands for Serotonin and Norepinephrine Uptake Sites. AU - Rung, Mei Ping. AU - Tejani-butt, Shanaz. AU - Frazer, Alan. AU - Brooks, Brian P.. AU - Szabo, Stephen A.. AU - Hung, Hank F.. AU - Chumpradit, Sumalee. AU - Panyachotipun, Chitchanum. AU - Prapanairi, Vichukorn. AU - Foulon, Catherine. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1992/11/1. Y1 - 1992/11/1. N2 - In order to develop selective radioactive ligands for the study of presynaptic monoamine uptake sites, iodinated derivatives of tomoxetine were synthesized and evaluated in radioligand binding assays. Iodotomoxetine derivatives showed high affinity for serotonin (5-HT) uptake sites using a rat cortical membrane preparation. Compound 1R, (R)-(-)-N-methyl-3-(4-iodo-2-methylphenoxy)-3-phenylpropanamine, was the most potent and showed high stereoselectivity for 5-HT uptake sites (K¡, R isomer = 0.65 nM, S isomer = 13.9 nM). Changing the ...
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Norepinephrine uptake into a crude preparation of rat brain synaptic vesicles showed a marked dependence on Mg2+ concentration. Mn2+ or Co+ could substitute for Mg2+, but displayed lower affinities. Zn2+, Ni2+ and Ca2+ stimulated uptake only slightly and other divalent cations were ineffective. ATP, GTP and UTP produced stimulation of norepinephrine uptake, but only ATP was fully effective. ADP and AMP inhibited the ATP-induced stimulation. The irreversible inhibitor of ATPases, N-ethylmaleimide (NEM), blocked norepinephrine uptake; the effect was enhanced by pre-incubation of the vesicle preparation with NEM prior to addition of the cofactors and the enhancement was partially prevented by addition of ATP-Mg2+ during the pre-incubation. Replacement of K+ by Na+ in the medium did not alter norepinephrine uptake, but Li+ inhibited uptake by competing with Mg2+. The use of hypertonic medium inhibited uptake, while hypotonic medium markedly enhanced only the nonspecific uptake component (not ATP or ...
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This is a 3-in-1 reference book. It gives a complete medical dictionary covering hundreds of terms and expressions relating to dermatology. It also gives extensive lists of bibliographic citations. Finally, it provides information to users on how to update their knowledge using various Internet resources ...
TCAs, specifically desipramine and nortriptyline (Pamelor), are superior to placebo at reducing ADHD symptoms in the short term (two to six weeks); however, the quality of evidence is low. Increased heart rate and diastolic blood pressure may be noted with treatment.
The clinical efficacy of promising cocaine anti-craving medications was examined in combination with buprenorphine. Twenty-one opioid-dependent cocaine abusers were enrolled in a double-blind, 12-week trial in which they received on a daily basis buprenorphine (8 mg, s.l.) plus either desipramine (150 mg, p.o.), amantadine (300 mg, p.o.), or fluoxetine (60 mg, p.o.). Urine samples and self-reported drug use were obtained 1-3 times/week. The order of greatest patient retention across the 12 weeks was desipramine (83.3%) > amantadine (66.7%) > fluoxetine (20.0%). The desipramine and amantadine groups appeared to have greater increases in opioid- and cocaine-free urines than the fluoxetine group. These results suggest that desipramine and amantadine may facilitate greater opioid and cocaine abstinence than fluoxetine. ...
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There is growing evidence of an interaction between dopamine and norepinephrine. To test the hypothesis that norepinephrine terminals are involved in the uptake and removal of dopamine from the extracellular space, the norepinephrine uptake blocker desmethylimipramine (DMI) was infused locally while …
Presence of specific dopamine (DA) receptors and their characterization was attempted in rat anococcygeus muscle preparation. Dopamine (10 -6 M) and B-HT 920 (10 -6 M) produced concentration dependent contractions of the rat anococcygeus muscle preparation. The response of DA was shifted towards right in presence of haloperidol (10 -6 M; pA 2 = 6.8) and sulpiride (10 -4 M) in a competitive manner. α 2 antagonists yohimbine (10 -5 M) and idazoxan (10 -5 M) blocked the response to DA in a competitive manner, while α 1 antagonist prazosin (10 -5 M) completely blocked the response to DA. SCH 23390 (10 -5 M), a D 1 DA antagonist potentiated the response to DA. Reserpinization (5 mg/kg, 24 hr prior) brought about a shift towards the right, and this response was similarly blocked by haloperidol, sulpiride and yohimbine without affecting the maximum response. Desipramine (10 -5 M) blocked the response of DA in a non-competitive manner. Pretreatment of animals with desipramine (10 mg/kg) followed by
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Bobon D, Breulet M, Gerard-Vandenhove MA, Guiot-Goffioul F, Plomteux G, Sastre-y-Hernandez M, Schratzer M, Troisfontaines B, von Frenckell R, Wachtel H. (1988). Is phosphodiesterase inhibition a new mechanism of antidepressant action? A double blind double-dummy study between rolipram and desipramine in hospitalized major and/or endogenous depressives. Eur Arch Psychiatry Neurol Sci 238 (1): 2-6. PMID 3063534. ...
Bioorg Med Chem Lett. 2008 Dec 1;18(23):6067-70. Epub 2008 Oct 11.Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors. To Reference ...
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ဆေးပညာအချက်အလက်များကို Hello Sayarwon တွင်ရှာဖွေနိုင်ပြီး၊ Imipramine (အင်မီပရာမင်း) , ၏ ဆေးညွှန်းများ၊ ဘေးထွက်ဆိုးကျိုးများနှင့်သတိပေးချက်များရှာဖွေနိုင်ပါသည်။
ဆေးပညာအချက်အလက်များကို Hello Sayarwon တွင်ရှာဖွေနိုင်ပြီး၊ Imipramine (အင်မီပရာမင်း) , ၏ ဆေးညွှန်းများ၊ ဘေးထွက်ဆိုးကျိုးများနှင့်သတိပေးချက်များရှာဖွေနိုင်ပါသည်။
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DESIPRAMINE 37. DEXETIMIDA 38. DEXFENFLURAMINE 39. DEXTROMETORFANO 40. DIBENZEPINE 41. DIMETRACRIN 42. DISOPIRAMIDE 43. ...
Desipramine (Re-Constriction) 1997 Desipramine Inefficient Machine Positive I.D. Bitch Denial Tragic Cinderella Trust in Me ... Waiting For God released two albums, Quarter Inch Thick and Desipramine, before breaking up. The members of Waiting For God ... Trashcan Bangin Culture #8. ^ Chaotic Critiques #8. 1000 Desipramine Pills. ...
Comparison of fluvoxamine and desipramine". Arch Gen Psychiatry. 47: 577-85. doi:10.1001/archpsyc.1990.01810180077011. PMID ...
... and desipramine are considered first-line medications for this condition. While amitriptyline and desipramine have been used as ... Hearn, L; Moore, RA; Derry, S; Wiffen, PJ; Phillips, T (Sep 23, 2014). "Desipramine for neuropathic pain in adults". The ...
Examples include imipramine, amitriptyline, nortriptyline and desipramine. Mirtazapine has demonstrated anxiolytic effects with ...
Among the TCAs, amitriptyline is most widely used for this condition, but desipramine and nortriptyline have fewer side effects ... TCAs include imipramine, amitriptyline, desipramine, and nortriptyline. They are generally regarded as first or second-line ...
Other dibenzazepine TCAs include imipramine, desipramine, and clomipramine. Trimipramine is a derivative of imipramine with a ... desipramine, doxepin, imipramine, and trimipramine) were identified. The mechanism of action of trimipramine in terms of its ...
Other secondary amine TCAs include desipramine and nortriptyline. The chemical name of protriptyline is 3-(5H-dibenzo[a,d][7] ...
Other secondary amine TCAs include desipramine and protriptyline. The chemical name of nortriptyline is 3-(10,11-dihydro-5H- ...
Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN (September 2007). "LeuT-desipramine structure reveals how ...
... desipramine). Imipramine is a tertiary amine TCA, with its side chain-demethylated metabolite desipramine being a secondary ... Desipramine has more affinity to norepinephrine transporter than imipramine. Dopamine: imipramine blocks D2 receptors. ... Imipramine, and its metabolite desipramine, have no appreciable affinity for the dopamine transporter (Ki = 8,500 and >10,000 ... Within the body, imipramine is converted into desipramine (desmethylimipramine) as a metabolite. Imipramine is a tricyclic ...
ISBN 1-4051-1071-6. Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN (2007). "LeuT-desipramine structure ... comparison to methylphenidate and desipramine". Drug and Alcohol Dependence. 75 (3): 271-6. doi:10.1016/j.drugalcdep.2004.03. ...
Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN (September 2007). "LeuT-desipramine structure reveals how ... and that desipramine had no effect on SERT. In a separate experiment, Horschitz et al. exposed HEK-SERT with citalopram on a ... or desipramine (an inhibitor of norepinephrine reuptake protein, NET). By examining the dose-response curves (using a normal ... such as desipramine) and SSRI's. Tri-cyclic antidepressants inhibit the reuptake of both serotonin and norepinephrine by acting ...
Nortriptyline, desipramine, and amoxapine are tricyclic antidepressants and secondary amines. (The tricyclics are grouped by ...
These drugs include amiodarone, desipramine, isoniazid, ketoconazole, letrozole, methoxsalen, tranylcypromine. The mechanisms ...
It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine. Florencio Zaragoza Dörwald (4 February 2013 ...
This is like comparing imipramine with desipramine, or amitriptyline with nortriptyline. N-demethylation has the effect of ...
Protriptyline (Vivactil), Nortriptyline (Pamelor), and Desipramine (Norpramin) are examples of these. Note: Only NRIs selective ... comparison to methylphenidate and desipramine". Drug and Alcohol Dependence. 75 (3): 271-6. doi:10.1016/j.drugalcdep.2004.03. ...
A Double Blind Comparative Trial of Nomifensin and Desipramine in Depression. Relation Between Treatment and Phenylethylamine ...
"Pharmacological properties of the active metabolites of the antidepressants desipramine and citalopram". Eur. J. Pharmacol. 576 ...
Clinically, quinupramine is reported to be stimulating similarly to imipramine, desipramine, and demexiptiline. It can be ...
Also, desipramine, dothiepin, phenelzine, tetrabenazine, and reserpine have been known to trigger NMS. At the molecular level, ...
Drugs used for this purpose include, as stated above, methylphenidate, amphetamines, atomoxetine, and desipramine. Linssen AM, ...
... comparison to methylphenidate and desipramine". Drug and Alcohol Dependence. 75 (3): 271-276. doi:10.1016/j.drugalcdep.2004.03. ...
This finding is based on the premise that desipramine is not self-administered, and also the fact that the NRI atomoxetine was ... AMPT led to a resurgence of depressive symptoms in patients improved by the NE reuptake inhibitor (NRI) desipramine, but not by ... Comparison to methylphenidate and desipramine". Drug and Alcohol Dependence. 75 (3): 271-6. doi:10.1016/j.drugalcdep.2004.03. ...
Desipramine and atomoxetine are not reliably self-administered though, whereas most selective DRIs are. SSRIs are not self- ...
Drugs used for this purpose include, as stated above, methylphenidate, amphetamines, atomoxetine, and desipramine. Linssen AM, ...
Tricyclic antidepressants (TCAs): amitriptyline, butriptyline, clomipramine, desipramine, dosulepin, doxepin, imipramine, ...
"Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine". FEBS ... Cinnarizine Clemastine Clofazimine Clomiphene Clomipramine Cloperastine Conessine Cyclobenzaprine Cyproheptadine Desipramine ...
demonstrated that clomipramine was more effective than desipramine in decreasing several types of repetitive behavior. Research ...
Desipramine definition, a tricyclic antidepressant, C 18 H 22 N 2 , used for symptomatic relief in a variety of depressive ... desipramine in Medicine Expand. desipramine de·sip·ra·mine (dĭ-zĭprə-mēn, dězə-prāmĭn). n. A tricyclic antidepressant used ...
With desipramine, it has been noted that up to a 36-fold difference in plasma levels can be observed in patients receiving the ... Desipramine, a metabolite of imipramine, has actions and uses similar to those of the parent compound and is as effective as ... Thus, desipramine may be especially useful in patients who are particularly sensitive to these effects (eg, the elderly). ... 3. Spina E, Avenoso A, Campo GM, Caputi AP, Perucca E. The effect of carbamazepine on the 2-hydroxylation of desipramine. ...
FDA safety notices may be specifically about desipramine or relate to a group or class of drugs which include desipramine. ... desipramine FDA Alerts. The FDA Alert(s) below may be specifically about desipramine or relate to a group or class of drugs ... Recent FDA Alert(s) for desipramine. Antidepressant Medication Products. May 2, 2007 ... which include desipramine.. MedWatch Safety Alerts are distributed by the FDA and published by Drugs.com. Following is a list ...
Find patient medical information for Desipramine Oral on WebMD including its uses, side effects and safety, interactions, ... Desipramine is very similar to imipramine. Do not take medications containing imipramine while using desipramine. ... Other medications can affect the removal of desipramine from your body, which may affect how desipramine works. Examples ... desipramine 10 mg tablet. color. light blue. shape. round. imprint. A A 1 1. This medicine is a light blue, round, film-coated ...
Desipramine was first approved by the FDA in 1964.. What are the major differences between Norpramin and other medications used ... The cost of the generic version desipramine is around $33.. Are there any disadvantages to Norpramin?. The biggest disadvantage ... Norpramin is a tricyclic antidepressant and brand name of the drug desipramine. It works by restoring balance to chemicals in ... Higher fatality rates are associated with desipramine overdoses compared to other tricyclic antidepressants. Overdose symptoms ...
Ratio-Desipramine indications, usages and related health products lists ... Ratio-Desipramine information about active ingredients, pharmaceutical forms and doses by Ratiopharm, ... Tablets; Oral; Desipramine Hydrochloride 10 mg*Tablets; Oral; Desipramine Hydrochloride 100 mg*Tablets; Oral; Desipramine ... Tablets; Oral; Desipramine Hydrochloride 50 mg*Tablets; Oral; Desipramine Hydrochloride 75 mg. ...
Desipramine for Improving Cellular Signaling and Decreasing Symptoms of Major Depression. The safety and scientific validity of ... Desipramine. Antidepressive Agents, Tricyclic. Antidepressive Agents. Psychotropic Drugs. Enzyme Inhibitors. Molecular ... A cohort of the depressed participants will be treated with desipramine. They will be examined to determine the drugs effect ... This study will determine the effectiveness of desipramine in improving cellular signaling, and thereby decreasing symptoms of ...
Desipramine (By mouth). Desipramine (des-IP-ra-meen). Treats depression. This medicine is a tricyclic antidepressant.. Brand ... Do not use it if you had an allergic reaction to desipramine or a recent heart attack.. How to Use This Medicine: Tablet. *Take ... Some medicines can affect how desipramine works. Tell your doctor if you are also using St Johns wort, buspirone, cimetidine, ... You must wait at least 5 weeks after you stop using fluoxetine before you can start using desipramine. ...
This eMedTV page describes desipramine in more detail, including an explanation of how it works and a list of potential side ... Desipramine is a prescription drug that is commonly used for the treatment of depression in adults. ... Who Makes Desipramine?. Desipramine is made by Sanofi-Aventis. Generic desipramine is made by several manufacturers of generic ... Interested in a Discount on Desipramine?. Our free DiscountRx savings card can help you and your family save money on your ...
This eMedTV page describes desipramine in more detail, including an explanation of how it works and a list of potential side ... This eMedTV page describes desipramine in more detail, including an explanation of how it works and a list of potential side ... Desipramine is a prescription drug that is commonly used for the treatment of depression in adults. ... Desipramine is a prescription drug that is commonly used for the treatment of depression in adults. ...
An analysis of parotid salivary gland function with desipramine and age in female NIA Fischer 344 rats. ... In this study we analyzed the effects of the long-term administration of the tricyclic antidepressant desipramine and the ... In this study we analyzed the effects of the long-term administration of the tricyclic antidepressant desipramine and the ... Surprisingly, parotid flow rate was increased with desipramine in all ages. While the concentration of secreted proteins was ...
... What is this medicine?. DESIPRAMINE (des IP ra meen) is used to treat depression. ... an unusual or allergic reaction to desipramine, other medicines, foods, dyes, or preservatives ...
What Is Desipramine Used For? - Depression Home Page - What is desipramine used for? As this eMedTV page explains, desipramine ... Desipramine Norpramin For Neuropathic Pain 2018. Desipramine - Wikipedia, the free encyclopedia - Desipramine (also known as ... Norpramin (Desipramine Hydrochloride) Drug … - Learn about the prescription medication Norpramin (Desipramine Hydrochloride), ... desipramine brand, desipramine hydrochloride, drug class, drug facts, drug interaction, drug interactions, drug norpramin, drug ...
Links to searches for DESIPRAMINE HYDROCHLORIDE can be found here. ... Use Google powered SiteComber to search within various sites for DESIPRAMINE HYDROCHLORIDE. ... Search for DESIPRAMINE HYDROCHLORIDE. Select any medical resource below to perform a Google powered SiteComber search for ... DESIPRAMINE HYDROCHLORIDE within any of the sites below. You instead may execute your own search for DESIPRAMINE HYDROCHLORIDE ...
An open-label, single-dose desipramine, multiple-dose HCV-796, sequential 3-period study to determine the pharmacokinetics of ... An open-label, single-dose desipramine, multiple-dose HCV-796, sequential 3-period study to determine the pharmacokinetics of ...
Desipramine is the generic name of the drug and its INN and BAN, while desipramine hydrochloride is its USAN, USP, BAN, and JAN ... Desipramine is the major metabolite of imipramine and lofepramine. Desipramine is a tricyclic compound, specifically a ... desipramine). Desipramine is a secondary amine TCA, with its N-methylated parent imipramine being a tertiary amine. Other ... Desipramine at very low doses is also used to help reduce the pain associated with functional dyspepsia. It has also been tried ...
Desipramine hydrochloride overdose occurs when someone takes more than ... Desipramine hydrochloride is a type of medicine called a tricyclic antidepressant. It is taken to relieve symptoms of ... An overdose of desipramine hydrochloride can be very serious. Complications such as pneumonia, muscle damage from lying on a ... Desipramine hydrochloride is a type of medicine called a tricyclic antidepressant. It is taken to relieve symptoms of ...
Information on the drug desipramine (Norpramin) prescribed for the treatment of depression. Off label uses include the ... Desipramine also causes elevated pressure in the eyes of some patients with glaucoma. Overdoses of desipramine can cause life- ... Desipramine elevates mood by raising the level of neurotransmitters in nerves of the brain. Desipramine also is responsible for ... How should I keep desipramine stored?. Desipramine should be stored at room temperature, below 86 F (30 C), in a tight, light ...
Rate your experience with desipramine oral on - WebMD including the side effects, drug interactions, effectiveness, ease of use ...
Use of Desipramine Hydrochloride With Other MAOIs Such as Linezolid or Methylene Blue. Do not start desipramine hydrochloride ... Who should not take Desipramine Hydrochloride? *You should not take desipramine hydrochloride if you take a monoamine oxidase ... Desipramine Hydrochloride Tablets USP. Suicidality and Antidepressant Drugs Antidepressants increased the risk compared to ... Do not start desipramine hydrochloride if you stopped taking an MAOI in the last 2 weeks unless directed to do so by your ...
Desipramine is used to treat symptoms of depression. Desipramine may also be used for purposes not listed in this medication ... Desipramine affects chemicals in the brain that may be unbalanced in people with depression. ... What is desipramine?. Desipramine is a tricyclic antidepressant. Desipramine affects chemicals in the brain that may be ... Desipramine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using desipramine. ...
Desipramine comes as an oral tablet and is available as a generic drug and as the brand-name drug Norpramin. Learn about side ... Desipramine is a prescription medication used to treat depression. It belongs to a class of drugs called tricyclic ... Drugs that should not be used with desipramine. Do not take these drugs with desipramine. When used with desipramine, these ... Desipramine is used to treat depression.. How it works. Time for medication to take effect. *Desipramine can start to work in 2 ...
A Moderate Drug Interaction exists between desipramine and dexbrompheniramine / pseudoephedrine. View detailed information ... Using desipramine together with dexbrompheniramine may increase side effects such as drowsiness, blurred vision, dry mouth, ... Drug Interactions between desipramine and dexbrompheniramine / pseudoephedrine. This report displays the potential drug ...
DESIPRAMINE HYDROCHLORIDE- desipramine hydrochloride tablet Number of versions: 2. Published Date (What is this?). Version. ... DESIPRAMINE HYDROCHLORIDE- desipramine hydrochloride tablet To receive this label RSS feed. Copy the URL below and paste it ... Who should not take desipramine hydrochloride tablets, USP? *You should not take desipramine hydrochloride tablets, USP if you ... desipramine hydrochloride is not recommended for use in children. Anyone considering the use of desipramine hydrochloride in a ...
Desipramine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Continue to take desipramine even if you feel well. Do not stop taking desipramine without talking to your doctor. If you ... Desipramine is used to treat depression. Desipramine is in a class of medications called tricyclic antidepressants. It works by ... Before taking desipramine,. *tell your doctor and pharmacist if you are allergic to desipramine, clomipramine (Anafranil), ...
Do not start taking desipramine during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping desipramine ... Desipramine is used to treat depression. It works by increasing the activity of a chemical called norepinephrine in the brain. ... Desipramine may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use ... Do not take desipramine with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], phenelzine [Nardil®], ...
Norpolake information about active ingredients, pharmaceutical forms and doses, Norpolake indications, usages and related health products lists
... oral desipramine, 3) combined lidocaine and desipramine, and 4) placebo cream and capsules. The duration of study drug will ... combined lidocaine and desipramine, and placebo cream and capsules. Desipramine is a tricyclic antidepressant commonly used by ... Vulvar Vestibulitis Clinical Trial: Desipramine-Lidocaine. The safety and scientific validity of this study is the ... This is to explore if the active desipramine/active lidocaine treatment has more advantages that may not be shown in the ANCOVA ...
Desipramine for neuropathic pain in adults. Neuropathic pain is pain coming from damaged nerves. It is different from pain ... To assess the analgesic efficacy of desipramine for chronic neuropathic pain in adults, and to assess the associated adverse ... Desipramine may also be useful in these painful conditions. In 2014, we performed searches to look for clinical trials where ... Desipramine is a tricyclic antidepressant from the same class of medicines as amitriptyline, which is widely recommended for ...
Desipramine (Norpramin) should be used with great caution in patients with a family history of sudden death, cardiac ... Desipramine (Norpramin) should be used with great caution in patients with a family history of sudden death, cardiac ... An overdose of desipramine is more likely to cause death than an overdose of other tricyclic antidepressants. ... Another new warning is that desipramine must be used with extreme caution in patients with a history of seizure disorder ...
Desipramine belongs to the class of medications known as tricyclic antidepressants. Desipramine helps to elevate mood and ... Tricyclic antidepressants such as desipramine work by increasing the amount of norepinephrine and serotonin neurotransmitters ( ... Desipramine belongs to the class of medications known as tricyclic antidepressants. Desipramine helps to elevate mood and ... Breast-feeding: Desipramine passes into breast milk. If you are a breast-feeding mother and are taking desipramine, it may ...
Risperidone and Desipramine in Alcohol Use and Schizophrenia (RADIAUS). The safety and scientific validity of this study is the ... placebo to an open label pre-post study of risperidone (or risperidone-like drug) + desipramine. The aims of the study were ... Experimental: Risperidone + Desipramine All participants will be treated with risperidone (or a risperidone-like agent ... Desipramine. Alcoholism. Schizophrenia. Schizophrenia Spectrum and Other Psychotic Disorders. Mental Disorders. Alcohol-Related ...
... desipramine (DMI) adjusted to an adequate plasma level, or the combination of FLX 20 mg/day and DMI, given under double-blind ...
An exposure of 10 min to 10−7M desipramine caused... ... The effect of desipramine on the cumulative dose-response ... Desipramine (10−7 M), in contact with the tissue for 10 min, enhanced responses to cumulative additions of K+ without causing a ... Wash-out of desipramine resulted in a rapid loss of enhanced maximum response to noradrenaline while the maximum response to K+ ... The effect of desipramine on the cumulative dose-response curves of noradrenaline and potassium (K+) was examined on the ...
Desipramine (DB01151). Interacting Gene/Enzyme. Cytochrome P450 2D6. Gene Name. CYP2D6. UniProt ID. P10635. Defining Change(s) ...
Pheochromocytoma Unmasked by Desipramine Therapy MICHAEL R. ACHONG, M.B.; PAUL M. KEANE, M.B. ... Pheochromocytoma Unmasked by Desipramine Therapy. Ann Intern Med. 1981;94:358-359. doi: 10.7326/0003-4819-94-3-358 ... We describe the unmasking of pheochromocytoma by desipramine therapy in a patient who showed no adverse effect while receiving ... Her symptoms had begun after two doses of desipramine (Norpramin, Merrell-National Laboratories, Cincinnati, Ohio), 25 mg, and ...
... desipramine), includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to ... What is desipramine (Norpramin)?. Desipramine is a tricyclic antidepressant. Desipramine affects chemicals in the brain that ... Desipramine is used to treat symptoms of depression.. Desipramine may also be used for purposes not listed in this medication ... Generic Name: desipramine (Pronunciation: des IP ra meen). *What is desipramine (Norpramin)? ...
Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population.. Dahl ML1, ... 187 extensive metabolizers and 36 poor metabolizers phenotyped with debrisoquin and desipramine. Restriction fragment length ... metabolizers who were heterozygous for wild-type and CYP2D6B genes had metabolic ratios for debrisoquin and desipramine that ...
  • Norpramin is a tricyclic antidepressant and brand name of the drug desipramine. (psycom.net)
  • Yes, the generic version of Norpramin is called desipramine and is available for purchase. (psycom.net)
  • A quantitative interresponse-time analysis of DRL performance differentiates similar effects of the antidepressant desipramine and the novel anxiolytic gepirone. (mysciencework.com)
  • Desipramine is used to treat depression . (webmd.com)
  • This study will determine the effectiveness of desipramine in improving cellular signaling, and thereby decreasing symptoms of depression in people with major depressive disorder (MDD). (clinicaltrials.gov)
  • DESIPRAMINE (des IP ra meen) is used to treat depression. (southcoast.org)
  • As this eMedTV page explains, desipramine is used for treating depression in adults. (newtreatmentsfordepression.net)
  • The FDA Alert(s) below may be specifically about desipramine or relate to a group or class of drugs which include desipramine. (drugs.com)
  • With desipramine, it has been noted that up to a 36-fold difference in plasma levels can be observed in patients receiving the same dose. (labcorp.com)
  • Desipramine, a metabolite of imipramine, has actions and uses similar to those of the parent compound and is as effective as imipramine in the treatment of mood disorders. (labcorp.com)
  • A cohort of the depressed participants will be treated with desipramine. (clinicaltrials.gov)
  • The increase in reinforcement rate observed with desipramine was accompanied by a coherent shift of the reinforcement rate observed with gepirone was accompanied by dispersal of the interresponse-time distribution toward the random negative exponential prediction. (mysciencework.com)
  • 2 One study compared desipramine monotherapy with carbamazepine co-administered. (labcorp.com)
  • Thus, desipramine may be especially useful in patients who are particularly sensitive to these effects (eg, the elderly). (labcorp.com)
  • Experiment 2 applied the analysis described in Experiment 1 to the effects of desipramine and gepirone. (mysciencework.com)
  • 3. Spina E, Avenoso A, Campo GM, Caputi AP, Perucca E. The effect of carbamazepine on the 2-hydroxylation of desipramine. (labcorp.com)
  • In this study we analyzed the effects of the long-term administration of the tricyclic antidepressant desipramine and the reversibility of this treatment following a 15-day washout period on different parameters in parotid gland function in aging rats. (uzh.ch)
  • The effect of desipramine on the cumulative dose-response curves of noradrenaline and potassium (K + ) was examined on the isolated rat vas deferens. (springer.com)
  • Age-dependent stimulatory effect of desipramine and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice. (nih.gov)
  • The aim of this study was to compare the effect of desipramine (a tricyclic antidepressant, TCA) and fluoxetine (a selective serotonin reuptake inhibitor, SSRI) on tumor growth of the mouse B16F10 transplanted melanoma in "young" 6-9 month old and "aged" 18-23 month old male C57BL/6 mice. (nih.gov)
  • The prometastatic effect of desipramine in young animals was connected with an increase of VEGF and MMP-9 plasma levels. (nih.gov)
  • These two effects are considered to be the likely base of the antidepressant effect of Desipramine. (pharmacycode.com)
  • The effect of desipramine was not affected by pretreatment with prazosin or propranolol, excluding catecholamine reuptake activity of desipramine as an underlying mechanism. (elsevier.com)
  • Desipramine is a tricyclic antidepressant from the same class of medicines as amitriptyline, which is widely recommended for treating neuropathic pain. (cochrane.org)
  • In 2014, we performed searches to look for clinical trials where desipramine was used to treat neuropathic pain. (cochrane.org)
  • There was too little information, which was of inadequate quality, to be sure that desipramine works as a pain medicine in painful diabetic neuropathy or postherpetic neuralgia, and no information about other types of neuropathic pain. (cochrane.org)
  • This review found little evidence to support the use of desipramine to treat neuropathic pain. (cochrane.org)
  • Desipramine is a tricyclic antidepressant that is occasionally used for treating neuropathic pain. (cochrane.org)
  • To assess the analgesic efficacy of desipramine for chronic neuropathic pain in adults, and to assess the associated adverse events. (cochrane.org)
  • Alleviation of symptoms in irritable bowel syndrome and neuropathic pain is accomplished by the antinociceptive properties of Desipramine. (statpearls.com)
  • The Onset of Treatment with the Antidepressant desipramine is Critical for the Emotional Consequences of Neuropathic Pain. (painresearchforum.org)
  • Secondary amine TCAs like desipramine and nortriptyline have a lower risk of orthostatic hypotension than other TCAs, although desipramine can still cause moderate orthostatic hypotension. (wikipedia.org)
  • Desipramine is particularly toxic in cases of overdose, compared to other antidepressants. (wikipedia.org)
  • Any overdose or suspected overdose of desipramine is considered to be a medical emergency and can result in death without prompt medical intervention. (wikipedia.org)
  • Desipramine hydrochloride overdose occurs when someone takes more than the normal or recommended amount of this medicine. (medlineplus.gov)
  • Below are symptoms of a desipramine hydrochloride overdose in different parts of the body. (medlineplus.gov)
  • An overdose of desipramine hydrochloride can be very serious. (medlineplus.gov)
  • An overdose of desipramine can be fatal. (cigna.com)
  • What should I do in case of a desipramine overdose? (sharecare.com)
  • In case of a desipramine overdose, you should call your local poison control center right away and seek immediate medical help. (sharecare.com)
  • Overdose with desipramine can be very dangerous. (emedtv.com)
  • Desipramine at very low doses is also used to help reduce the pain associated with functional dyspepsia. (wikipedia.org)
  • What are the available doses of DESIPRAMINE HYDROCHLORIDE? (themedidex.com)
  • Predictions were that amitriptyline would decrease MB and increase aggression relative to desipramine, particularly at higher doses. (frontiersin.org)
  • Amitriptyline and desipramine differentially reduced MB, and at higher doses reduced aggressive behavior. (frontiersin.org)
  • Desipramine is an oral antidepressant , a member of the tricyclic antidepressant (TCA) family which also includes amitriptyline ( Elavil , Endep ), and imipramine ( Tofranil ). (medicinenet.com)
  • We describe the unmasking of pheochromocytoma by desipramine therapy in a patient who showed no adverse effect while receiving amitriptyline intermittently over 9 years. (annals.org)
  • Desipramine oral tablet is available as a brand-name drug and a generic drug. (healthline.com)
  • Desipramine oral tablet may cause drowsiness. (healthline.com)
  • Desipramine comes as a tablet to take by mouth. (medlineplus.gov)
  • Desipramine comes in tablet form and is available in a number of strengths. (emedtv.com)
  • 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787194/7/Desipramine. (hopkinsguides.com)
  • The investigators have demonstrated that RISP (a medication that is both a DA D2 receptor antagonist, and a potent NE α2 receptor antagonist), in combination with the specific NE reuptake inhibitor desipramine, significantly decreases alcohol consumption in alcohol drinking rodents. (clinicaltrials.gov)
  • Do not stop using desipramine suddenly , or you could have unpleasant withdrawal symptoms. (cigna.com)
  • The observed effectiveness of desipramine in the treatment of ADHD was the basis for the development of the selective NRI atomoxetine and its use in ADHD. (wikipedia.org)
  • In addition to these mechanisms, desipramine appears to downregulate beta-adrenergic receptors and serotonin receptors. (statpearls.com)
  • Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. (pharmacycode.com)
  • What are the side effects of desipramine? (medicinenet.com)
  • Cimetidine ( Tagamet ) can increase desipramine blood levels, possibly causing side effects. (medicinenet.com)
  • Dangerous side effects or death can occur when alcohol is combined with desipramine. (cigna.com)
  • The study will also compare the effects of risperidone as compared to risperidone plus desipramine on participants' symptoms and side effects. (clinicaltrials.gov)
  • As with any medicine, there are possible side effects with desipramine. (emedtv.com)
  • When desipramine side effects do occur, they are often minor and either require no treatment or can easily be treated by your healthcare provider. (emedtv.com)
  • Serious side effects of desipramine are less common. (emedtv.com)
  • Click Desipramine Side Effects to learn about specific side effects of the medication, including some of the more serious side effects that you should report to your healthcare provider. (emedtv.com)
  • How should I take desipramine? (cigna.com)
  • Who should not take Desipramine HCL? (webmd.com)
  • Children younger than 18 years of age should not normally take desipramine, but in some cases, a doctor may decide that desipramine is the best medication to treat a child's condition. (medlineplus.gov)
  • You should know that your mental health may change in unexpected ways when you take desipramine or other antidepressants even if you are an adult over age 24. (medlineplus.gov)
  • Take desipramine at around the same time(s) every day. (medlineplus.gov)
  • Take desipramine exactly as directed. (medlineplus.gov)
  • Continue to take desipramine even if you feel well. (medlineplus.gov)
  • What should I talk to my health care provider before I take DESIPRAMINE HYDROCHLORIDE? (themedidex.com)
  • Twenty-one opioid-dependent cocaine abusers were enrolled in a double-blind, 12-week trial in which they received on a daily basis buprenorphine (8 mg, s.l.) plus either desipramine (150 mg, p.o.), amantadine (300 mg, p.o.), or fluoxetine (60 mg, p.o. (cocaine.org)
  • You must wait at least 5 weeks after you stop using fluoxetine before you can start using desipramine. (limamemorial.org)
  • The antidepressants desipramine and fluoxetine were compared in vivo to the glucocorticoid prednisolone, an anti-inflammatory drug of reference. (biomedcentral.com)
  • Prednisolone and fluoxetine reduced the number of macrophages, lymphocytes, neutrophils and eosinophils, while desipramine diminished only the number of macrophages and lymphocytes. (biomedcentral.com)
  • Desipramine and fluoxetine reduce the inflammatory reaction in two animal models of human diseases. (biomedcentral.com)
  • The desipramine and amantadine groups appeared to have greater increases in opioid- and cocaine-free urines than the fluoxetine group. (cocaine.org)
  • These results suggest that desipramine and amantadine may facilitate greater opioid and cocaine abstinence than fluoxetine. (cocaine.org)
  • Desipramine hydrochloride is not approved for use in pediatric patients. (nih.gov)
  • Desipramine is the generic name of the drug and its INN and BAN, while desipramine hydrochloride is its USAN, USP, BAN, and JAN. Its generic name in French and its DCF are désipramine, in Spanish and Italian and its DCIT are desipramina, in German is desipramin, and in Latin is desipraminum. (wikipedia.org)
  • Chronic use of desipramine also leads to down-regulation of beta-adrenergic receptors in the cerebral cortex and sensitization of serotonergic receptors. (selfdecode.com)
  • What is the dosage for desipramine? (medicinenet.com)
  • The likelihood of having suicidal thoughts while taking desipramine is the highest within the early months of treatment or whenever dosage increases. (therecoveryvillage.com)
  • The influence of desipramine on thyroid hormone metabolism in rat brain. (aspetjournals.org)
  • The effect of the antidepressant desipramine (DMI) on the activities of the three iodothyronine deiodinase isoenzymes involved in the central metabolism of thyroid hormones were investigated in 11 brain regions and 3 peripheral tissues in the rat. (aspetjournals.org)
  • Increased analgesia and alterations in distribution and metabolism of methadone by desipramine in the rat. (aspetjournals.org)
  • We will study the clinical efficacy of four medical treatments for vulvar vestibulitis: topical lidocaine, oral desipramine, combined lidocaine and desipramine, and placebo cream and capsules. (clinicaltrials.gov)
  • It is hypothesized that the combined use of oral desipramine and topical lidocaine will be more therapeutically effective than either one by itself and better than placebo. (clinicaltrials.gov)
  • The Vulvar Vestibulitis Clinical Trial (VVCT) is a randomized, placebo-controlled, double-blinded clinical trial to study the clinical efficacy of four medical treatments for vulvar vestibulitis: 1) topical lidocaine, 2) oral desipramine, 3) combined lidocaine and desipramine, and 4) placebo cream and capsules. (clinicaltrials.gov)
  • A hierarchical (gatekeeping) testing strategy to maintain a family-wise error rate will be adopted as the following: the first stage will compare desipramine or lidocaine individually to placebo with multiplicity-adjusted p-values. (clinicaltrials.gov)
  • The six-week, double-blind, placebo-controlled study assessed the differences in the reduction of ADHD symptoms in adults receiving desipramine or placebo. (xhbv.com)
  • The research suggests that 68% of subjects receiving desipramine responded to treatment, compared with none of the subjects who received placebo. (xhbv.com)
  • Desipramine tends to be less sedating than other TCAs and tends to produce fewer anticholinergic effects like dry mouth, constipation, urinary retention, blurred vision, and cognitive/memory impairment. (wikipedia.org)
  • Desipramine has the weakest antihistamine and anticholinergic effects of the TCAs. (wikipedia.org)
  • Whereas other TCAs are useful for treating insomnia, desipramine can cause insomnia as a side effect due to its activating properties. (wikipedia.org)
  • Overdoses of desipramine can cause life-threatening abnormal heart rhythms or seizures . (medicinenet.com)
  • Desipramine also possesses minor anticholinergic activity, through its affinity for muscarinic receptors. (selfdecode.com)
  • Your healthcare provider will want to see you often while you are taking desipramine, especially at the beginning of your treatment. (medlineplus.gov)
  • The primary hypothesis is that compared to treatment with risperidone, participants randomized to a combination of risperidone plus desipramine will have fewer days of drinking, as well as fewer days of heavy drinking. (clinicaltrials.gov)
  • Efficacy of desipramine can be established within the first 2 weeks of treatment of bulimia nervosa patients. (statpearls.com)
  • Desipramine has shown mild effectiveness in the treatment of ADHD. (statpearls.com)
  • One study is available examining the efficacy of desipramine in the treatment of adult ADHD. (xhbv.com)
  • Here we have investigated how hypothalamic neurons respond to treatment with antidepressants, including desipramine and sibutramine. (elsevier.com)
  • Is desipramine available as a generic drug? (medicinenet.com)
  • Desipramine hydrochloride USP is an antidepressant drug of the tricyclic type, and is chemically: 5 H -Dibenz[ bƒ ]azepine-5-propanamine,10,11-dihydro- N -methyl-, monohydrochloride. (nih.gov)
  • Desipramine is a prescription drug. (healthline.com)
  • Wash-out of desipramine resulted in a rapid loss of enhanced maximum response to noradrenaline while the maximum response to K + did not show any decrease for up to 120 min after wash-out of drug. (springer.com)
  • There are nine drug master file entries for desipramine hydrochloride. (drugpatentwatch.com)
  • At that point, the levels of desipramine in the body are much lower than is detectable by typical drug tests. (therecoveryvillage.com)
  • Desipramine hydrochloride USP is an antidepressant drug of the tricyclic type available as tablets of 10 mg, 25 mg, 50 mg, 75 mg, 100 mg or 150 mg for oral administration. (themedidex.com)
  • What is desipramine, and how does it work (mechanism of action)? (medicinenet.com)
  • The effects of desipramine on the total body plasma clearance (Cl) as well as the systemic fractional extraction (ER S ) of noradrenaline, dopamine, adrenaline, and isoprenaline, and on the pulmonary fractional extraction (ER p ) of dopamine and adrenaline were determined in the anaesthetized rabbit. (springer.com)
  • Desipramine reduced the Cl of noradrenaline (by 20%), but did not affect that of the other amines. (springer.com)
  • Desipramine may increase suicidal thoughts or behaviors. (healthline.com)
  • A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as desipramine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). (medlineplus.gov)
  • The biggest danger of desipramine is its link to heightened suicidal thoughts. (therecoveryvillage.com)
  • Anyone considering the use of desipramine hydrochloride tablets or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. (nih.gov)
  • Desipramine is administered orally and comes in tablets of 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, and 150 mg. (statpearls.com)
  • Desipramine also is responsible for the antidepressant effects of imipramine because imipramine is converted by the body to desipramine. (medicinenet.com)
  • An overall increase in serotonergic transmission likely confers desipramine its antidepressant effects. (selfdecode.com)