Desipramine. Medical search

A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.

The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.

The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.

A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.

Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of noradrenergic neurons. They remove NOREPINEPHRINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. It regulates signal amplitude and duration at noradrenergic synapses and is the target of ADRENERGIC UPTAKE INHIBITORS.

Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.

A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.

A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.

A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.

A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.

Compounds with two BENZENE rings fused to AZEPINES.

A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)

A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.

An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.

An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.

Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.

Hallucinogenic alkaloid isolated from the flowering heads (peyote) of Lophophora (formerly Anhalonium) williamsii, a Mexican cactus used in Indian religious rites and as an experimental psychotomimetic. Among its cellular effects are agonist actions at some types of serotonin receptors. It has no accepted therapeutic uses although it is legal for religious use by members of the Native American Church.

One of the SEROTONIN UPTAKE INHIBITORS formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of GUILLAIN-BARRE SYNDROME associated with its use. (From Martindale, The Extra Pharmacopoeia, 29th ed, p385)

An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.

A serotonin uptake inhibitor that is effective in the treatment of depression.

Compounds that specifically inhibit the reuptake of serotonin in the brain.

A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.

The action of a drug that may affect the activity, metabolism, or toxicity of another drug.

A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.

A monoamine oxidase inhibitor with antihypertensive properties.

Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.

An enzyme that catalyzes the hydrolysis of a ceramidetrihexoside to a ceramidedihexoside plus galactose.

A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.

A selective serotonin uptake inhibitor that is used in the treatment of depression.

One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.

Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.

An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.

An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)

Neurons whose primary neurotransmitter is EPINEPHRINE.

A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.

An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.

A group of compounds that are methyl derivatives of the amino acid TYROSINE.

Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.

Conceptual system developed by Freud and his followers in which unconscious motivations are considered to shape normal and abnormal personality development and behavior.

Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo: effect of chronic antidepressant drug treatment. (1/521)

1. Intracerebral microdialysis was used to examine the function of the terminal 5-hydroxytryptamine (5-HT) autoreceptor in the anterior hypothalamus of anaesthetized rats at two points in the light phase of the light-dark cycle. 2. Infusion of the 5-HT1A/1B agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole (RU24969) 0.1, 1.0 and 10 microM through the microdialysis probe led to a concentration-dependent decrease (49, 56 and 65% respectively) in 5-HT output. The effect of RU24969 (1 and 5 microM) was prevented by concurrent infusion of methiothepin (1 and 10 microM) into the anterior hypothalamus via the microdialysis probe. Infusion of methiothepin alone (1.0 and 10 microM) increased (15 and 142% respectively) 5-HT output. 3. Infusion of RU24969 (5 microM) through the probe at mid-light and end-light resulted in a quantitatively greater decrease in 5-HT output at end-light compared with mid-light. 4. Following treatment with either paroxetine hydrochloride (10 mg kg(-1) i.p.) or desipramine hydrochloride (10 mg kg)(-1) i.p.) for 21 days the function of the terminal 5-HT1B autoreceptor was more markedly attenuated at end-light. 5. The data show that, as defined by the response to RU24969, the function of the 5-HT1B receptors that control 5-HT output in the anterior hypothalamus is attenuated following chronic desipramine or paroxetine treatment in a time-of-day-dependent manner. (+info)

Neuronal uptake affects dynamic characteristics of heart rate response to sympathetic stimulation. (2/521)

Recently, studies in our laboratory involving the use of a Gaussian white noise technique demonstrated that the transfer function from sympathetic stimulation frequency to heart rate (HR) response showed dynamic characteristics of a second-order low-pass filter. However, determinants for the characteristics remain to be established. We examined the effect of an increase in mean sympathetic stimulation frequency and that of a blockade of the neuronal uptake mechanism on the transfer function in anesthetized rabbits. We found that increasing mean sympathetic stimulation frequency from 1 to 4 Hz significantly (P < 0.01) decreased the dynamic gain of the transfer function without affecting other parameters, such as the natural frequency, lag time, or damping coefficient. In contrast, the administration of desipramine (0.3 mg/kg iv), a neuronal uptake blocking agent, significantly (P < 0.01) decreased both the dynamic gain and the natural frequency and prolonged the lag time. These results suggest that the removal rate of norepinephrine at the neuroeffector junction, rather than the amount of available norepinephrine, plays an important role in determining the low-pass filter characteristics of the HR response to sympathetic stimulation. (+info)

Alpha 1-adrenergic receptor-mediated increase in the mass of phosphatidic acid and 1,2-diacylglycerol in ischemic rat heart. (3/521)

OBJECTIVE: 1,2-Diacylglycerol (1,2-DAG) and phosphatidic acid (PA) are produced by phospholipase C and D activity and play a key role as second messengers in receptor-mediated signal transduction. So far, little is known about alterations of endogenous 1,2-DAG and PA production during myocardial ischemia. METHODS: Rat isolated perfused hearts were subjected to global ischemia, total lipids were extracted, and separated by thin-layer chromatography. The mass of PA and 1,2-DAG were quantified using laserdensitometric analysis of visualized lipids. RESULTS: Compared to normoxic control values (1,2-DAG 713 +/- 45 ng/mg protein, PA 171 +/- 11 ng/mg protein), the myocardial content of 1,2-DAG and PA was unaltered after 10 min of ischemia. Prolonged myocardial ischemia (20 min), however, which was accompanied by marked overflow of endogenous norepinephrine, significantly increased the mass of both second messengers (1,2-DAG 1062 +/- 100 ng/mg protein, PA 340 +/- 29 ng/mg protein). The increase in PA and 1,2-DAG in response to ischemia was abolished by inhibition of ischemia-induced norepinephrine release as well as by alpha1-adrenergic blockade but unaffected by beta-adrenergic blockade. While inhibition of diacylglycerol kinase did not affect ischemia-induced increase in PA and 1,2-DAG, inhibition of phosphatidylinositol-specific phospholipase C activity significantly suppressed ischemia-induced increase in 1,2-DAG but did not affect endogenous production of PA indicating phospholipase C-independent formation of PA and activation of both, phospholipase C and D, in the ischemic heart. CONCLUSIONS: Ischemia elicits an alpha1-adrenergic receptor-mediated increase in the mass of myocardial PA and 1,2-DAG. The increase in endogenous PA is suggested to be due to the activation of myocardial phospholipase D, whereas 1,2-DAG is formed predominantly by activation of phospholipase C in the ischemic heart. (+info)

Enhancement of the serotonin-mediated acetylcholine release by repeated desmethylimipramine treatment in the hippocampus of freely moving rats. (4/521)

A possible involvement of serotonin-mediated cholinergic activation in the antidepressant effect of desmethylimipramine (DMI) was investigated by determination of the effects of a single or repeated DMI administration on acetylcholine (ACh) release in the hippocampus using an in vivo microdialysis technique and a radioimmunoassay for ACh. Rats were administered DMI (10 mg/kg, i.p.) acutely or repeatedly for 21 days. A single or repeated DMI administration did not cause any significant effects on the basal ACh release compared with the respective controls. Atropine perfusion in the acutely DMI-treated or control rats increased the ACh release to the same degree. In repeatedly DMI-treated rats, serotonin (5-HT) (1 to 10 microM) perfusion enhanced significantly the ACh release. However, 5-HT in acutely DMI-treated rats enhanced significantly the ACh release only at 10 microM. 5-HT did not cause any changes in ACh release in control rats. Hippocampal 5-HT content of acutely DMI-treated rats was significantly higher than that of saline-treated control rats, while no difference was observed between the repeatedly DMI- and saline-treated rats. These findings suggest, for the first time, that DMI induced a facilitation of cholinergic neurotransmission in the rat hippocampus through the activation of 5-HT-receptor function. (+info)

Electrochemical and electrophysiological characterization of neurotransmitter release from sympathetic nerves supplying rat mesenteric arteries. (5/521)

1. Characteristic features of noradrenaline (NA) and adenosine 5'-triphosphate (ATP) release from postganglionic sympathetic nerves in rat small mesenteric arteries in vitro have been investigated on an impulse-by-impulse basis. NA release was measured using continuous amperometry and ATP release was monitored by intracellular recording of excitatory junction potentials (e.j.ps). 2. Electrical stimuli evoked transient increases in oxidation current. During trains of ten stimuli at 0.5 - 4 Hz there was a depression in the amplitude of oxidation currents evoked following the first stimulus in the train. 3. The neuronal NA uptake inhibitor, desmethylimipramine (1 microM), increased the amplitude of the summed oxidation current evoked by ten stimuli at 1 Hz and slowed the decay of oxidation currents evoked by trains of ten stimuli at 1 and 10 Hz. 4. The alpha2-adrenoceptor antagonist, idazoxan (1 microM), increased the amplitudes of the oxidation currents evoked during trains of ten stimuli at 0.5 - 10 Hz but had no effect on the oxidation currents evoked by the first stimulus in the train. 5. Idazoxan (1 microM) increased the amplitude of all e.j.ps evoked during trains of stimuli at 0.5 and 1 Hz. In addition, the facilitatory effect of idazoxan on e.j.ps was significantly greater than that on oxidation currents. 6. The findings indicate that NA release from sympathetic nerves supplying small mesenteric arteries is regulated by activation of presynaptic alpha2-adrenoceptors and that clearance of released NA in this tissue depends, in part, upon neuronal uptake. The different effects of idazoxan on the oxidation currents and e.j.ps may indicate that the release of NA and ATP is differentially modulated. (+info)

Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline- and methoxamine-evoked constriction of the dorsal hand vein. (6/521)

AIMS: To examine whether the antidepressant venlafaxine, a novel serotonin-noradrenaline re-uptake inhibitor (SNRI), can modify alpha-adrenoceptor-mediated venoconstriction in man. The effects of venlafaxine were compared with those of desipramine, a tricyclic antidepressant with noradrenaline uptake inhibiting properties, and paroxetine, a selective serotonin re-uptake inhibitor (SSRI), on noradrenaline-and methoxamine-evoked venoconstriction using the dorsal hand vein compliance technique. METHODS: Fifteen healthy male volunteers participated in five weekly experimental sessions. Each session was associated with a clinically effective dose of an antidepressant or placebo. The following oral dosages were used: venlafaxine 75 mg, venlafaxine 150 mg, desipramine 100 mg, paroxetine 20 mg, or placebo. A double-blind, cross-over, balanced design was used. In each session, dose-response curves to both locally infused noradrenaline acid tartrate (0.1-33.33 ng min-1 ) and methoxamine hydrochloride (0.5-121.5 microg min-1 ) were constructed. Systolic and diastolic blood pressure and pulse rate were measured in the supine and erect positions. Salivation was measured by the dental roll technique. RESULTS: Venlafaxine 150 mg and desipramine 100 mg potentiated the venoconstrictor response to noradrenaline (anova of log ED50s: P<0.01; individual comparisons: venlafaxine 150 mg vs placebo: P<0.005; mean difference, 95% CI: -0. 49 (-0.81, -0.17); desipramine 100 mg vs placebo: P<0.005; mean difference, 95% CI: -0.34 (-0.60, -0.09) without affecting the response to methoxamine. Neither paroxetine nor placebo had any effects on the venoconstrictor responses. Both doses of venlafaxine increased systolic blood pressure (supine and erect) and venlafaxine 150 mg increased diastolic blood pressure (supine) (anova, P<0.05). Desipramine increased heart rate (P<0.05). Desipramine and both doses of venlafaxine reduced salivation (P<0.025). CONCLUSIONS: These results show that, similarly to desipramine 100 mg, venlafaxine 150 mg can potentiate venoconstrictor responses to noradrenaline, consistent with venlafaxine's ability to block noradrenaline uptake in man. The importance of noradrenaline uptake blockade in these observations is confirmed by the lack of effect of the antidepressants on methoxamine-evoked venoconstriction and the failure of paroxetine to modify noradrenaline-evoked venoconstriction. (+info)

Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation. (7/521)

Ziprasidone is a novel antipsychotic agent which binds with high affinity to 5-HT1A receptors (Ki = 3.4 nM), in addition to 5-HT1D, 5-HT2, and D2 sites. While it is an antagonist at these latter receptors, ziprasidone behaves as a 5-HT1A agonist in vitro in adenylate cyclase measurements. The goal of the present study was to examine the 5-HT1A properties of ziprasidone in vivo using as a marker of central 5-HT1A activity the inhibition of firing of serotonin-containing neurons in the dorsal raphe nucleus. In anesthetized rats, ziprasidone dose-dependently slowed raphe unit activity (ED50 = 300 micrograms/kg i.v.) as did the atypical antipsychotics clozapine (ED50 = 250 micrograms/kg i.v.) and olanzapine (ED50 = 1000 micrograms/kg i.v.). Pretreatment with the 5-HT1A antagonist WAY-100,635 (10 micrograms/kg i.v.) prevented the ziprasidone-induced inhibition; the same dose of WAY-100,635 had little effect on the inhibition produced by clozapine and olanzapine. Because all three agents also bind to alpha 1 receptors, antagonists of which inhibit serotonin neuronal firing, this aspect of their pharmacology was assessed with desipramine (DMI), a NE re-uptake blocker previously shown to reverse the effects of alpha 1 antagonists on raphe unit activity. DMI (5 mg/kg i.v.) failed to reverse the inhibitory effect of ziprasidone but produced nearly complete reversal of that of clozapine and olanzapine. These profiles suggest a mechanism of action for each agent, 5-HT1A agonism for ziprasidone and alpha 1 antagonism for clozapine and olanzapine. The 5-HT1A agonist activity reported here clearly distinguishes ziprasidone from currently available antipsychotic agents and suggests that this property may play a significant role in its pharmacologic actions. (+info)

LLC-PK(1) cells stably expressing the human norepinephrine transporter: A functional model of carrier-mediated norepinephrine release in protracted myocardial ischemia. (8/521)

In myocardial ischemia, adrenergic terminals undergo ATP depletion, hypoxia, and intracellular pH reduction, causing the accumulation of axoplasmic norepinephrine (NE) and intracellular Na(+) [via the Na(+)-H(+) exchanger (NHE)]. This forces the reversal of the Na(+)- and Cl(-)-dependent NE transporter (NET), triggering massive carrier-mediated NE release and, thus, arrhythmias. We have now developed a cellular model of carrier-mediated NE release using an LLC-PK(1) cell line stably transfected with human NET cDNA (LLC-NET). LLC-NET cells transported [(3)H]NE and [(3)H]N-methyl-4-phenylpyridinium ([(3)H]MPP(+)) in an inward direction. This uptake was abolished by the NET inhibitors desipramine (100 nM) and mazindol (300 nM) and by extracellular Na(+) removal. Na(+)-gradient reversal induced an efflux of (3)H-substrate from preloaded LLC-NET cells. Desipramine and mazindol blocked this efflux. Because of its greater intracellular stability and higher sensitivity to Na(+)-gradient reversal, [(3)H]MPP(+) proved preferable to [(3)H]NE as an NET substrate; therefore, only [(3)H]MPP(+) was used for subsequent studies. The K(+)/H(+) ionophore nigericin (10 microM) evoked a large efflux of [(3)H]MPP(+). This efflux was potentiated by the Na(+),K(+)-ATPase inhibitor ouabain (100 microM), was sensitive to desipramine, and was blocked by the NHE inhibitor 5-(N-ethyl-N-isopropyl)-amiloride (EIPA; 10 microM). In contrast, EIPA failed to inhibit the [(3)H]MPP(+) efflux elicited by the Na(+) ionophore gramicidin (10 microM). Furthermore, [(3)H]MPP(+) efflux induced by the NHE-stimulant proprionate (25 mM) was negatively modulated by imidazoline receptor activation. Our findings suggest that LLC-NET cells are a sensitive model for studying transductional processes of carrier-mediated NE release associated with myocardial ischemia. (+info)

DESIPRAMINE 37. DEXETIMIDA 38. DEXFENFLURAMINE 39. DEXTROMETORFANO 40. DIBENZEPINE 41. DIMETRACRIN 42. DISOPIRAMIDE 43. ...

https://en.wikipedia.org/wiki/Brazilian_Controlled_Drugs_and_Substances_Act

Objectively, I'm going to have to say 'I'm going to make the most of my life.'" [4] Waiting for God (KMG, 1994) Desipramine ( ... Waiting For God released two albums, Quarter Inch Thick and Desipramine, before breaking up. The members of Waiting For God ... Trashcan Bangin Culture #8. ^ Chaotic Critiques #8. 1000 Desipramine Pills. ...

https://en.wikipedia.org/wiki/Waiting_for_God_(band)

"desipramine (Rx) - Norpramin". Medscape Drugs & Diseases. Otasowie, J; Castells, X; Ehimare, UP; Smith, CH (19 September 2014 ... There is good empirical evidence for short-term safety and efficacy for the use of desipramine, bupropion and atomoxetine. ... These include the alpha-2 agonists (clonidine and guanfacine), tricyclic antidepressants (desipramine and nortriptyline), and ... Methylphenidate, guanfacine, clonidine, and desipramine were associated with improvement of tic symptoms. Controversy remains, ...

https://en.wikipedia.org/wiki/Attention_deficit_hyperactivity_disorder_management

Comparison of fluvoxamine and desipramine". Arch Gen Psychiatry. 47: 577-85. doi:10.1001/archpsyc.1990.01810180077011. PMID ...

https://en.wikipedia.org/wiki/Wayne_Goodman

CS1 maint: discouraged parameter (link) Dean Miles, Larry (1997). "Waiting for God: Desipramine" (PDF). Black Monday (7): 1. ...

https://en.wikipedia.org/wiki/In_Radiant_Decay

Hearn L, Moore RA, Derry S, Wiffen PJ, Phillips T (September 2014). Hearn L (ed.). "Desipramine for neuropathic pain in adults ... imapramine, and desipramine,) serotonin-norepinephrine reuptake inhibitor (SNRI) medications (duloxetine, venlafaxine, and ... Cochrane systematically reviewed the evidence for the antidepressants nortriptyline, desipramine, venlafaxine and milnacipran ...

https://en.wikipedia.org/wiki/Peripheral_neuropathy

Among the TCAs, amitriptyline is most widely used for this condition, but desipramine and nortriptyline have fewer side effects ... TCAs include imipramine, amitriptyline, desipramine, and nortriptyline. They are generally regarded as first or second-line ...

https://en.wikipedia.org/wiki/Diabetic_neuropathy

Other dibenzazepine TCAs include imipramine, desipramine, and clomipramine. Trimipramine is a derivative of imipramine with a ... desipramine, doxepin, imipramine, and trimipramine) were identified. The mechanism of action of trimipramine in terms of its ...

https://en.wikipedia.org/wiki/Trimipramine

Examples include imipramine, doxepin, amitriptyline, nortriptyline and desipramine. Mirtazapine has demonstrated anxiolytic ...

https://en.wikipedia.org/wiki/Anxiolytic

Other secondary amine TCAs include desipramine and protriptyline. The chemical name of nortriptyline is 3-(10,11-dihydro-5H- ... 752-. ISBN 978-3-88763-075-1. "ChemIDplus - 62265-06-9 - AMLRZIZSGSCSHZ-UHFFFAOYSA-N - Desipramine dibudinate - Similar ...

https://en.wikipedia.org/wiki/Nortriptyline

Although lofepramine is technically a tertiary amine, it acts in large part as a prodrug of desipramine, and is more similar to ... The desipramine metabolite is partly secreted in the faeces. Other routes of metabolism include hydroxylation, glucuronidation ... Lofepramine has been said to be a prodrug of desipramine, although there is also evidence against this notion. Lofepramine is ... Lofepramine is a tertiary amine TCA, with its side chain-demethylated metabolite desipramine being a secondary amine. Unlike ...

https://en.wikipedia.org/wiki/Lofepramine

Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN (September 2007). "LeuT-desipramine structure reveals how ...

https://en.wikipedia.org/wiki/Serotonin_transporter

... desipramine). Imipramine is a tertiary amine TCA, with its side chain-demethylated metabolite desipramine being a secondary ... Desipramine has more affinity to norepinephrine transporter than imipramine. Dopamine: imipramine blocks D2 receptors. ... Imipramine, and its metabolite desipramine, have no appreciable affinity for the dopamine transporter (Ki = 8,500 and >10,000 ... Blood levels between 150-250 ng/mL of imipramine plus its metabolite desipramine generally correspond to antidepressant ...

https://en.wikipedia.org/wiki/Imipramine

Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN (September 2007). "LeuT-desipramine structure reveals how ... and that desipramine had no effect on SERT. In a separate experiment, Horschitz et al. exposed HEK-SERT with citalopram on a ... or desipramine (an inhibitor of norepinephrine reuptake protein, NET). By examining the dose-response curves (using a normal ... such as desipramine) and SSRIs. Tricyclic antidepressants inhibit the reuptake of both serotonin and norepinephrine by acting ...

https://en.wikipedia.org/wiki/Reuptake

"LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake". Science. New York, N.Y. 317 (5843): ...

https://en.wikipedia.org/wiki/Bacterial_Leucine_Transporter

Nortriptyline, desipramine, and amoxapine are tricyclic antidepressants and secondary amines. (The tricyclics are grouped by ...

https://en.wikipedia.org/wiki/Amine

These drugs include amiodarone, desipramine, isoniazid, ketoconazole, letrozole, methoxsalen, tranylcypromine. The mechanisms ...

https://en.wikipedia.org/wiki/Artesunate

Marin, Kocsis, Frances, and Parides (1994) conducted an eight-week open trial that entailed the administration of desipramine ... Marin, D.; Kocsis, J.; Frances, A.; Parides, M. (1994). "Desipramine for the treatment of "pure" dysthymia versus "double" ...

https://en.wikipedia.org/wiki/Double_depression

It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine. Florencio Zaragoza Dörwald (4 February 2013 ...

https://en.wikipedia.org/wiki/Demexiptiline

"The methylphenidate test for differentiating desipramine-responsive from nortriptyline-responsive depression". The American ...

https://en.wikipedia.org/wiki/Jan_Fawcett

Protriptyline (Vivactil), nortriptyline (Pamelor), and desipramine (Norpramin) are examples of these. Note: Only NRIs selective ... comparison to methylphenidate and desipramine". Drug and Alcohol Dependence. 75 (3): 271-6. doi:10.1016/j.drugalcdep.2004.03. ...

https://en.wikipedia.org/wiki/Norepinephrine_reuptake_inhibitor

A Double Blind Comparative Trial of Nomifensin and Desipramine in Depression. Relation Between Treatment and Phenylethylamine ...

https://en.wikipedia.org/wiki/Julio_Moizeszowicz

These include the alpha-2 agonists (clonidine and guanfacine). There is good empirical support for the use of desipramine, ... There is moderate evidence supporting that clonidine combined with methylphenidate, desipramine, and methylphenidate alone ... reduce tics more than placebo when ADHD is also present; desipramine is rarely used following reports of sudden death in ...

https://en.wikipedia.org/wiki/Management_of_Tourette_syndrome

Desipramine - may improve working memory and attention when used at certain doses. Nicergoline may improve human cognitive ...

https://en.wikipedia.org/wiki/Nootropic

"Pharmacological properties of the active metabolites of the antidepressants desipramine and citalopram". Eur. J. Pharmacol. 576 ...

https://en.wikipedia.org/wiki/Muscarinic_antagonist

Clinically, quinupramine is reported to be stimulating similarly to imipramine, desipramine, and demexiptiline. It can be ...

https://en.wikipedia.org/wiki/Quinupramine

Additionally, desipramine, dothiepin, phenelzine, tetrabenazine, and reserpine have been known to trigger NMS. Whether lithium ...

https://en.wikipedia.org/wiki/Neuroleptic_malignant_syndrome

... comparison to methylphenidate and desipramine". Drug and Alcohol Dependence. 75 (3): 271-6. doi:10.1016/j.drugalcdep.2004.03. ...

https://en.wikipedia.org/wiki/Tesofensine

This finding is based on the premise that desipramine is not self-administered, and also the fact that the NRI atomoxetine was ... AMPT led to a resurgence of depressive symptoms in patients improved by the NE reuptake inhibitor (NRI) desipramine, but not by ... Comparison to methylphenidate and desipramine". Drug and Alcohol Dependence. 75 (3): 271-6. doi:10.1016/j.drugalcdep.2004.03. ...

https://en.wikipedia.org/wiki/Serotonin–norepinephrine–dopamine_reuptake_inhibitor

doi:10.1016/S0011-393X(97)80088-4. Grandoso L, Pineda J, Ugedo L (May 2004). "Comparative study of the effects of desipramine ... However, norepinephrine-selective antidepressants, such as reboxetine and desipramine, have successfully treated anxiety ...

https://en.wikipedia.org/wiki/Serotonin–norepinephrine_reuptake_inhibitor

Desipramine is the generic name of the drug and its INN and BAN, while desipramine hydrochloride is its USAN, USP, BAN, and JAN ... Desipramine is the major metabolite of imipramine and lofepramine. Desipramine is a tricyclic compound, specifically a ... desipramine). Desipramine is a secondary amine TCA, with its N-methylated parent imipramine being a tertiary amine. Other ... Desipramine at very low doses is also used to help reduce the pain associated with functional dyspepsia. It has also been tried ...

https://en.wikipedia.org/wiki/Desipramine

Aiding & Abetting gave Desipramine a positive review, calling it "much edgier sound than the first album" and saying "the ... Adapted from the Desipramine liner notes. Waiting for God Daemon Cadman - lead vocals Martin Myers - guitar, keyboards, ... Desipramine is the second studio album by Waiting for God, released in 1997 by Synthetic Symphony. ... CS1 maint: discouraged parameter (link) Dean Miles, Larry (1997). "Waiting for God: Desipramine" (PDF). Black Monday (7): 16. ...

https://en.wikipedia.org/wiki/Desipramine_(album)

Desipramine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Continue to take desipramine even if you feel well. Do not stop taking desipramine without talking to your doctor. If you ... Desipramine is used to treat depression. Desipramine is in a class of medications called tricyclic antidepressants. It works by ... Before taking desipramine,. *tell your doctor and pharmacist if you are allergic to desipramine, clomipramine (Anafranil), ...

https://medlineplus.gov/druginfo/meds/a682387.html

Desipramine hydrochloride overdose occurs when someone takes more than ... Desipramine hydrochloride is a type of medicine called a tricyclic antidepressant. It is taken to relieve symptoms of ... An overdose of desipramine hydrochloride can be very serious. Complications such as pneumonia, muscle damage from lying on a ... Desipramine hydrochloride is a type of medicine called a tricyclic antidepressant. It is taken to relieve symptoms of ...

https://medlineplus.gov/ency/article/002626.htm

Desipramine definition, a tricyclic antidepressant, C 18 H 22 N 2 , used for symptomatic relief in a variety of depressive ... desipramine in Medicine Expand. desipramine de·sip·ra·mine (dĭ-zĭprə-mēn, dězə-prāmĭn). n. A tricyclic antidepressant used ...

http://www.dictionary.com/browse/desipramine?qsrc=2446

With desipramine, it has been noted that up to a 36-fold difference in plasma levels can be observed in patients receiving the ... Desipramine, a metabolite of imipramine, has actions and uses similar to those of the parent compound and is as effective as ... Thus, desipramine may be especially useful in patients who are particularly sensitive to these effects (eg, the elderly). ... 3. Spina E, Avenoso A, Campo GM, Caputi AP, Perucca E. The effect of carbamazepine on the 2-hydroxylation of desipramine. ...

https://www.labcorp.com/test-menu/24036/desipramine

Information on the drug desipramine (Norpramin) prescribed for the treatment of depression. Off label uses include the ... Desipramine also causes elevated pressure in the eyes of some patients with glaucoma. Overdoses of desipramine can cause life- ... Desipramine elevates mood by raising the level of neurotransmitters in nerves of the brain. Desipramine also is responsible for ... How should I keep desipramine stored?. Desipramine should be stored at room temperature, below 86 F (30 C), in a tight, light ...

https://www.medicinenet.com/desipramine/article.htm

Rate your experience with desipramine oral on - WebMD including the side effects, drug interactions, effectiveness, ease of use ...

https://www.webmd.com/drugs/drugreviewpost-8323-desipramine+oral.aspx?post=new&

Use of Desipramine Hydrochloride With Other MAOIs Such as Linezolid or Methylene Blue. Do not start desipramine hydrochloride ... Who should not take Desipramine Hydrochloride? *You should not take desipramine hydrochloride if you take a monoamine oxidase ... Desipramine Hydrochloride Tablets USP. Suicidality and Antidepressant Drugs Antidepressants increased the risk compared to ... Do not start desipramine hydrochloride if you stopped taking an MAOI in the last 2 weeks unless directed to do so by your ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=91304d6c-8e23-4c00-85cd-5b8e2a784c38

Desipramine is used to treat symptoms of depression. Desipramine may also be used for purposes not listed in this medication ... Desipramine affects chemicals in the brain that may be unbalanced in people with depression. ... What is desipramine?. Desipramine is a tricyclic antidepressant. Desipramine affects chemicals in the brain that may be ... Desipramine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using desipramine. ...

https://www.cigna.com/individuals-families/health-wellness/hw/medications/desipramine-d00145a1

Desipramine comes as an oral tablet and is available as a generic drug and as the brand-name drug Norpramin. Learn about side ... Desipramine is a prescription medication used to treat depression. It belongs to a class of drugs called tricyclic ... Drugs that should not be used with desipramine. Do not take these drugs with desipramine. When used with desipramine, these ... Desipramine is used to treat depression.. How it works. Time for medication to take effect. *Desipramine can start to work in 2 ...

https://www.healthline.com/health/desipramine-oral-tablet

FDA safety notices may be specifically about desipramine or relate to a group or class of drugs which include desipramine. ... desipramine FDA Alerts. The FDA Alert(s) below may be specifically about desipramine or relate to a group or class of drugs ... Recent FDA Alert(s) for desipramine. Antidepressant Medication Products. May 2, 2007 ... which include desipramine.. MedWatch Safety Alerts are distributed by the FDA and published by Drugs.com. Following is a list ...

https://www.drugs.com/fda-alerts/802-0.html

Generic name: Desipramine hydrochloride. Brand name: Norpramin. Pronounced: NOR-pram-in. Norpramin (desipramine) Full ... Staff, H. (2009, January 3). Norpramin (Desipramine) Patient Information, HealthyPlace. Retrieved on 2021, April 16 from https ... www.healthyplace.com/other-info/psychiatric-medications/norpramin-desipramine-patient-information ...

https://www.healthyplace.com/other-info/psychiatric-medications/norpramin-desipramine-patient-information

Find patient medical information for Desipramine Oral on WebMD including its uses, side effects and safety, interactions, ... Desipramine is very similar to imipramine. Do not take medications containing imipramine while using desipramine. ... Other medications can affect the removal of desipramine from your body, which may affect how desipramine works. Examples ... desipramine 10 mg tablet. color. light blue. shape. round. imprint. A A 1 1. This medicine is a light blue, round, film-coated ...

https://www.webmd.com/drugs/2/drug-8323/desipramine-oral/details

A Moderate Drug Interaction exists between desipramine and dexbrompheniramine / pseudoephedrine. View detailed information ... Using desipramine together with dexbrompheniramine may increase side effects such as drowsiness, blurred vision, dry mouth, ... Drug Interactions between desipramine and dexbrompheniramine / pseudoephedrine. This report displays the potential drug ...

https://www.drugs.com/drug-interactions/desipramine-with-dexbrompheniramine-pseudoephedrine-802-0-822-0.html

encoded search term (Desipramine Level) and Desipramine Level What to Read Next on Medscape ... Desipramine Level Updated: Feb 12, 2020 * Author: Bishnu Prasad Devkota, MD, MHI, FRCS(Edin), FRCS(Glasg), FACP, FAMIA; Chief ... 5] Desipramine has been found useful in the therapy of irritable bowel syndrome (IBS). Empiric evidence for efficacy of its use ... Desipramine falls in the broad group of tricyclic antidepressants (TCA). Currently, it is used primarily in depression that is ...

https://emedicine.medscape.com/article/2089930-overview

DESIPRAMINE HYDROCHLORIDE- desipramine hydrochloride tablet Number of versions: 2. Published Date (What is this?). Version. ... DESIPRAMINE HYDROCHLORIDE- desipramine hydrochloride tablet To receive this label RSS feed. Copy the URL below and paste it ... Who should not take desipramine hydrochloride tablets, USP? *You should not take desipramine hydrochloride tablets, USP if you ... desipramine hydrochloride is not recommended for use in children. Anyone considering the use of desipramine hydrochloride in a ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ee14dd2c-c54b-4cd1-a3a0-f7ad5a5a0ed0

Do not start taking desipramine during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping desipramine ... Desipramine is used to treat depression. It works by increasing the activity of a chemical called norepinephrine in the brain. ... Desipramine may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use ... Do not take desipramine with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], phenelzine [Nardil®], ...

http://www.mayoclinic.org/drugs-supplements/desipramine-oral-route/description/drg-20071955?p=1

DESIPRAMINE, 10MG, TABLET. Common uses. This medication is typically used for depression. It may also be used to assist in the ...

https://www.uniprix.com/en/drug-lexicon/02216248/desipramine

Norpolake information about active ingredients, pharmaceutical forms and doses, Norpolake indications, usages and related health products lists

https://drugs-about.com/drugs-n/norpolake.html

... oral desipramine, 3) combined lidocaine and desipramine, and 4) placebo cream and capsules. The duration of study drug will ... combined lidocaine and desipramine, and placebo cream and capsules. Desipramine is a tricyclic antidepressant commonly used by ... Vulvar Vestibulitis Clinical Trial: Desipramine-Lidocaine. The safety and scientific validity of this study is the ... This is to explore if the active desipramine/active lidocaine treatment has more advantages that may not be shown in the ANCOVA ...

https://www.clinicaltrials.gov/ct2/show/NCT00276068

Desipramine was first approved by the FDA in 1964.. What are the major differences between Norpramin and other medications used ... The cost of the generic version desipramine is around $33.. Are there any disadvantages to Norpramin?. The biggest disadvantage ... Norpramin is a tricyclic antidepressant and brand name of the drug desipramine. It works by restoring balance to chemicals in ... Higher fatality rates are associated with desipramine overdoses compared to other tricyclic antidepressants. Overdose symptoms ...

https://www.psycom.net/adhd-medications-norpramin-desipramine/

Desipramine for neuropathic pain in adults. Neuropathic pain is pain coming from damaged nerves. It is different from pain ... To assess the analgesic efficacy of desipramine for chronic neuropathic pain in adults, and to assess the associated adverse ... Desipramine may also be useful in these painful conditions. In 2014, we performed searches to look for clinical trials where ... Desipramine is a tricyclic antidepressant from the same class of medicines as amitriptyline, which is widely recommended for ...

http://www.cochrane.org/CD011003/SYMPT_desipramine-for-neuropathic-pain-in-adults

Ratio-Desipramine indications, usages and related health products lists ... Ratio-Desipramine information about active ingredients, pharmaceutical forms and doses by Ratiopharm, ... Tablets; Oral; Desipramine Hydrochloride 10 mg*Tablets; Oral; Desipramine Hydrochloride 100 mg*Tablets; Oral; Desipramine ... Tablets; Oral; Desipramine Hydrochloride 50 mg*Tablets; Oral; Desipramine Hydrochloride 75 mg. ...

http://drugs-about.com/drugs-r/ratio-desipramine.html

Desipramine (Norpramin) should be used with great caution in patients with a family history of sudden death, cardiac ... Desipramine (Norpramin) should be used with great caution in patients with a family history of sudden death, cardiac ... An overdose of desipramine is more likely to cause death than an overdose of other tricyclic antidepressants. ... Another new warning is that desipramine must be used with extreme caution in patients with a history of seizure disorder ...

https://www.nursingcenter.com/journalarticle?Article_ID=1010884

Desipramine belongs to the class of medications known as tricyclic antidepressants. Desipramine helps to elevate mood and ... Tricyclic antidepressants such as desipramine work by increasing the amount of norepinephrine and serotonin neurotransmitters ( ... Desipramine belongs to the class of medications known as tricyclic antidepressants. Desipramine helps to elevate mood and ... Breast-feeding: Desipramine passes into breast milk. If you are a breast-feeding mother and are taking desipramine, it may ...

http://www.medbroadcast.com/drug/getdrug/dom-desipramine

Desipramine should not be used by certain people. If you are pregnant or breastfeeding, you should talk to your doctor about ... Desipramine should not be used by certain people. If you are pregnant or breastfeeding, you should talk to your doctor about ... If you have recently suffered a heart attack, desipramine may not be right for you. Also, if you have current or past problems ... If you have bipolar disease, schizophrenia or other mental illness, desipramine may not be right for you.. ...

https://www.sharecare.com/health/antidepressants/not-take-desipramine-hydrochloride

Risperidone and Desipramine in Alcohol Use and Schizophrenia (RADIAUS). The safety and scientific validity of this study is the ... placebo to an open label pre-post study of risperidone (or risperidone-like drug) + desipramine. The aims of the study were ... Experimental: Risperidone + Desipramine All participants will be treated with risperidone (or a risperidone-like agent ... Desipramine. Alcoholism. Schizophrenia. Schizophrenia Spectrum and Other Psychotic Disorders. Mental Disorders. Alcohol-Related ...

https://www.clinicaltrials.gov/ct2/show/NCT01411085?term=DESIPRAMINE&rank=11

... desipramine (DMI) adjusted to an adequate plasma level, or the combination of FLX 20 mg/day and DMI, given under double-blind ...

https://www.biopsychiatry.com/noradrenaline-serotonin.htm

An exposure of 10 min to 10−7M desipramine caused... ... The effect of desipramine on the cumulative dose-response ... Desipramine (10−7 M), in contact with the tissue for 10 min, enhanced responses to cumulative additions of K+ without causing a ... Wash-out of desipramine resulted in a rapid loss of enhanced maximum response to noradrenaline while the maximum response to K+ ... The effect of desipramine on the cumulative dose-response curves of noradrenaline and potassium (K+) was examined on the ...

https://link.springer.com/article/10.1007/BF00499227

Desipramine hydrochloride is found in the medicine called Norpramin. (medlineplus.gov)
Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. (wikipedia.org)
Desipramine is available as a brand-name drug called Norpramin. (healthline.com)
Norpramin is a tricyclic antidepressant and brand name of the drug desipramine. (psycom.net)
Yes, the generic version of Norpramin is called desipramine and is available for purchase. (psycom.net)
Desipramine (Norpramin) should be used with great caution in patients with a family history of sudden death, cardiac arrhythmias, or cardiac conduction disturbances. (nursingcenter.com)
The warnings on the label of desipramine (Norpramin), a tricyclic antidepressant, have been revised (go to http://bit.ly/d064qf ). (nursingcenter.com)
Norpramin (desipramine) Drug Side Effects, Interactions, and Medication Information on eMedicineHealth. (emedicinehealth.com)
What is desipramine (Norpramin)? (emedicinehealth.com)
What is the most important information I should know about desipramine (Norpramin)? (emedicinehealth.com)
What should I discuss with my healthcare provider before taking desipramine (Norpramin)? (emedicinehealth.com)
Desipramine hydrochloride ( Norpramin ® ) is a prescription medication that is used to treat depression (also known as major depression or clinical depression). (emedtv.com)
Desipramine (norpramin) is a non-selective tricyclic antidepressant used to treat major depression, ocd, enuresis, and various anxiety disorders. (healthtap.com)
Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked. (iodine.com)
Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized. (iodine.com)
Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants. (iodine.com)
Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma. (iodine.com)
Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants. (iodine.com)
In some people, Norpramin (desipramine) can make you sleepy. (iodine.com)
In other people, Norpramin (desipramine) can keep you awake. (iodine.com)
If you have diabetes, Norpramin (desipramine) can make your blood sugar go up. (iodine.com)
Norpramin (Desipramine) How Long Does It Stay In Your System? (therecoveryvillage.com)
Desipramine, commonly sold under the brand name Norpramin , can stay in your system anywhere between 1.5 to 4 days. (therecoveryvillage.com)
Mixing alcohol and Norpramin (desipramine) is not recommended. (therecoveryvillage.com)

Desipramine is in a class of medications called tricyclic antidepressants. (medlineplus.gov)
Evidence indicates that the secondary amine tricyclic antidepressants, including desipramine hydrochloride, may have greater activity in blocking the re-uptake of norepinephrine. (nih.gov)
Tricyclic antidepressants, such as desipramine hydrochloride, are rapidly absorbed from the gastrointestinal tract. (nih.gov)
Desipramine belongs to a class of drugs called tricyclic antidepressants . (healthline.com)
Desipramine falls in the broad group of tricyclic antidepressants (TCA). (medscape.com)
Desipramine is a tricyclic antidepressant commonly used by clinicians for treatment of several chronic pain conditions that demonstrates an optimal side effect profile compared to other tricyclic antidepressants. (clinicaltrials.gov)
An overdose of desipramine is more likely to cause death than an overdose of other tricyclic antidepressants. (nursingcenter.com)
Further, according to the manufacturer, overdoses of desipramine are more likely to cause death than are overdoses of other tricyclic antidepressants. (nursingcenter.com)
Desipramine belongs to the class of medications known as tricyclic antidepressants . (medbroadcast.com)
Tricyclic antidepressants such as desipramine work by increasing the amount of norepinephrine and serotonin neurotransmitters (chemical substances in the brain) available in certain parts of the brain. (medbroadcast.com)
Secondary amine tricycle antidepressants such as desipramine have been proposed to have greater norepinephrine blockade compared to that of tertiary amine tricyclic antidepressants, which have greater blockade at serotonin receptors. (statpearls.com)
Relative to the drug class of tricyclic antidepressants, desipramine is the least likely to cause the side effects listed. (statpearls.com)

Desipramine is used to treat depression. (medlineplus.gov)
Desipramine is primarily used for the treatment of depression. (wikipedia.org)
Desipramine affects chemicals in the brain that may be unbalanced in people with depression. (cigna.com)
Desipramine helps to elevate mood and eliminate or reduce other symptoms associated with depression. (medbroadcast.com)
For the treatment of depression in adults, the recommended starting dose of desipramine is 75 mg in divided doses, with or without food. (medbroadcast.com)
This study will determine the effectiveness of desipramine in improving cellular signaling, and thereby decreasing symptoms of depression in people with major depressive disorder (MDD). (clinicaltrials.gov)
Desipramine is a type of tricyclic antidepressant that is licensed to treat depression in adults. (emedtv.com)
Desipramine is a secondary amine tricyclic antidepressant that is FDA approved for the treatment of depression. (statpearls.com)
DESIPRAMINE (des IP ra meen) is used to treat depression. (southcoast.org)
Desipramine hydrochloride is indicated for the treatment of depression. (themedidex.com)
Desipramine may be used to treat depression, neuropathic pain (unlabeled use), agitation and insomnia (unlabeled use) and attention-deficit hyperactivity disorder (unlabeled use). (selfdecode.com)
As this eMedTV page explains, desipramine is used for treating depression in adults. (newtreatmentsfordepression.net)
Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. (pharmacycode.com)
Desipramine-yohimbine combination treatment of refractory depression. (brown.edu)

The effect of desipramine on the cumulative dose-response curves of noradrenaline and potassium (K + ) was examined on the isolated rat vas deferens. (springer.com)
Age-dependent stimulatory effect of desipramine and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice. (nih.gov)
The aim of this study was to compare the effect of desipramine (a tricyclic antidepressant, TCA) and fluoxetine (a selective serotonin reuptake inhibitor, SSRI) on tumor growth of the mouse B16F10 transplanted melanoma in "young" 6-9 month old and "aged" 18-23 month old male C57BL/6 mice. (nih.gov)
The prometastatic effect of desipramine in young animals was connected with an increase of VEGF and MMP-9 plasma levels. (nih.gov)
These two effects are considered to be the likely base of the antidepressant effect of Desipramine. (pharmacycode.com)
Antimalarial effect in vitro and lack of modulating effect of desipramine and imipramine. (bvsalud.org)
Based on previous studies in vitro of the modulating effect of desipramine on chloroquine -resistance of Plasmodium falciparum , the effect of desipramine and imipramine on freshly isolated resistant Brazilian strains of the parasite was investigated. (bvsalud.org)
The most common side effect of desipramine is drowsiness. (therecoveryvillage.com)
The effect of desipramine was not affected by pretreatment with prazosin or propranolol, excluding catecholamine reuptake activity of desipramine as an underlying mechanism. (elsevier.com)

Desipramine comes as a tablet to take by mouth. (medlineplus.gov)
Desipramine oral tablet is available as a brand-name drug and a generic drug. (healthline.com)
Desipramine oral tablet may cause drowsiness. (healthline.com)
Desipramine comes in tablet form and is available in a number of strengths. (emedtv.com)

In this study we analyzed the effects of the long-term administration of the tricyclic antidepressant desipramine and the reversibility of this treatment following a 15-day washout period on different parameters in parotid gland function in aging rats. (uzh.ch)

Desipramine hydrochloride overdose occurs when someone takes more than the normal or recommended amount of this medicine. (medlineplus.gov)
Below are symptoms of a desipramine hydrochloride overdose in different parts of the body. (medlineplus.gov)
An overdose of desipramine hydrochloride can be very serious. (medlineplus.gov)
Desipramine is particularly toxic in cases of overdose, compared to other antidepressants. (wikipedia.org)
Any overdose or suspected overdose of desipramine is considered to be a medical emergency and can result in death without prompt medical intervention. (wikipedia.org)
An overdose of desipramine can be fatal. (cigna.com)
Desipramine levels are increased in overdose. (medscape.com)
What should I do in case of a desipramine overdose? (sharecare.com)
In case of a desipramine overdose, you should call your local poison control center right away and seek immediate medical help. (sharecare.com)
Overdose with desipramine can be very dangerous. (emedtv.com)

tell your doctor and pharmacist if you are allergic to desipramine, clomipramine (Anafranil), imipramine (Tofranil), trimipramine (Surmontil), any other medications, or any of the ingredients in desipramine tablets. (medlineplus.gov)
Other dibenzazepine TCAs include imipramine (N-methyldesipramine), clomipramine, trimipramine, and lofepramine (N-(4-chlorobenzoylmethyl)desipramine). (wikipedia.org)
You should not take this medication if you have recently had a heart attack , or if you are allergic to desipramine or to similar antidepressants such as amitriptyline , amoxapine , clomipramine , doxepin , imipramine , nortriptyline , protriptyline , or trimipramine . (emedicinehealth.com)
Desipramine exerts less anticholinergic and sedative side effects compared to tertiary amine TCAs, such as amitriptyline and clomipramine. (selfdecode.com)

Desipramine is a tricyclic antidepressant from the same class of medicines as amitriptyline, which is widely recommended for treating neuropathic pain. (cochrane.org)
In 2014, we performed searches to look for clinical trials where desipramine was used to treat neuropathic pain. (cochrane.org)
There was too little information, which was of inadequate quality, to be sure that desipramine works as a pain medicine in painful diabetic neuropathy or postherpetic neuralgia, and no information about other types of neuropathic pain. (cochrane.org)
This review found little evidence to support the use of desipramine to treat neuropathic pain. (cochrane.org)
Desipramine is a tricyclic antidepressant that is occasionally used for treating neuropathic pain. (cochrane.org)
To assess the analgesic efficacy of desipramine for chronic neuropathic pain in adults, and to assess the associated adverse events. (cochrane.org)
Alleviation of symptoms in irritable bowel syndrome and neuropathic pain is accomplished by the antinociceptive properties of Desipramine. (statpearls.com)
The Onset of Treatment with the Antidepressant desipramine is Critical for the Emotional Consequences of Neuropathic Pain. (painresearchforum.org)

Children younger than 18 years of age should not normally take desipramine, but in some cases, a doctor may decide that desipramine is the best medication to treat a child's condition. (medlineplus.gov)
You should know that your mental health may change in unexpected ways when you take desipramine or other antidepressants even if you are an adult over age 24. (medlineplus.gov)
Take desipramine at around the same time(s) every day. (medlineplus.gov)
Take desipramine exactly as directed. (medlineplus.gov)
Continue to take desipramine even if you feel well. (medlineplus.gov)
How should I take desipramine? (cigna.com)
Who should not take Desipramine HCL? (webmd.com)
Also, if you have current or past problems with urinating you should not take desipramine. (sharecare.com)
Most important, if you are taking a monoamine oxidase inhibitor (MAOI) or have stopped taking it within the last two weeks, you should not take desipramine. (sharecare.com)
What should I talk to my health care provider before I take DESIPRAMINE HYDROCHLORIDE? (themedidex.com)

Your doctor may start you on a low dose of desipramine and gradually increase your dose. (medlineplus.gov)
With desipramine, it has been noted that up to a 36-fold difference in plasma levels can be observed in patients receiving the same dose. (labcorp.com)
Up to a 36-fold difference in plasma level may be noted among individuals taking the same oral dose of desipramine. (nih.gov)
However, elderly patients are more likely to have confusion, falling episodes, and age-related kidney problems, which may require an adjustment in the dose for patients receiving desipramine. (mayoclinic.org)
It was not possible to combine information from the different studies, but individually they indicated some benefit from desipramine (usually at a dose between 100 mg and 150 mg daily), compared with placebo , at the expense of increased adverse events. (cochrane.org)
An exposure of 10 min to 10 −7 M desipramine caused a leftward shift and an increase in the maximum response of cumulative dose-response curves of noradrenaline. (springer.com)
However, if you usually take your dose at night, you may not want to make up the missed dose, due to the risk of drowsiness that desipramine may cause if it is taken during the day. (emedtv.com)
Do not take a double dose of desipramine. (emedtv.com)
This study will compare the pharmacokinetics of omeprazole, rosiglitazone and desipramine when administered with a single oral dose of avanafil in healthy male subjects. (clinicaltrials.gov)
Treatment A: a single oral dose of 50 mg desipramine following an overnight fast of at least 10 hours. (clinicaltrials.gov)
The avanafil dose will be administered 2 hours after the desipramine administration. (clinicaltrials.gov)
Intrapatient dose escalation of desipramine. (clinicalconnection.com)
In vitro, desipramine and fluoxetine dose-dependently inhibited the release of TNF-α from LPS-treated monocytes. (biomedcentral.com)

Desipramine is a very potent and relatively selective norepinephrine reuptake inhibitor (NRI), which is thought to enhance noradrenergic neurotransmission. (wikipedia.org)
Westfall, D. P.: Antagonism by protriptyline and desipramine of the response of the vas deferens of the rat to norepinephrine, acetylcholine and potassium. (springer.com)
Desipramine has been shown to have therapeutic antinociceptive benefits most likely via its influence of norepinephrine. (statpearls.com)
Antinociceptive effects of desipramine are believed to be achieved via manipulation of norepinephrine. (statpearls.com)
This antibody binds to desipramine, a tricyclic antidepressant which inhibits the reuptake of noradrenaline/norepinephrine. (absoluteantibody.com)
Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. (selfdecode.com)
Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. (selfdecode.com)
Desipramine is a tricyclic antidepressant (TCA) that selectively blocks reuptake of norepinephrine (noradrenaline) from the neuronal synapse. (selfdecode.com)
In this study, we extended our studies to include chronic gestational treatment with desipramine or amitriptyline to examine differential effects of reuptake inhibition of norepinephrine and combined noradrenergic and serotonergic systems on MB, aggression, and oxytocin system changes. (frontiersin.org)
Pregnant Sprague-Dawley rats were treated throughout gestation with saline or one of three doses of either desipramine, which has a high affinity for the norepinephrine monoamine transporter, or amitriptyline, an agent with high affinity for both the norepinephrine and serotonin monoamine transporters. (frontiersin.org)

Desipramine at very low doses is also used to help reduce the pain associated with functional dyspepsia. (wikipedia.org)
What are the available doses of DESIPRAMINE HYDROCHLORIDE? (themedidex.com)
Predictions were that amitriptyline would decrease MB and increase aggression relative to desipramine, particularly at higher doses. (frontiersin.org)
Amitriptyline and desipramine differentially reduced MB, and at higher doses reduced aggressive behavior. (frontiersin.org)
Both drugs in therapeutic doses showed an unexpected antimalarial effect in vitro in duplicate tests ( IC50 = 44.26 and 46.53 micrograms/L for desipramine , and 83.93 and 41.26 micrograms/L for imipramine ), but no reversal of resistance when added to cultures together with chloroquine . (bvsalud.org)

You must wait at least 5 weeks after you stop using fluoxetine before you can start using desipramine. (limamemorial.org)
Any prohibited drugs must be discontinued at least 2 weeks or 5-half lives prior to the initiation of desipramine, whichever is shortest (except fluoxetine, because of long half life, will need a at least a 5 week washout period). (clinicalconnection.com)
The antidepressants desipramine and fluoxetine were compared in vivo to the glucocorticoid prednisolone, an anti-inflammatory drug of reference. (biomedcentral.com)
In the septic shock model, all three drugs given preventively markedly decreased circulating levels of TNF-α and mortality (50% mortality in fluoxetine treated group, 30% in desipramine and prednisolone treated groups versus 90% in controls). (biomedcentral.com)
Prednisolone and fluoxetine reduced the number of macrophages, lymphocytes, neutrophils and eosinophils, while desipramine diminished only the number of macrophages and lymphocytes. (biomedcentral.com)
Desipramine and fluoxetine reduce the inflammatory reaction in two animal models of human diseases. (biomedcentral.com)
Twenty-one opioid-dependent cocaine abusers were enrolled in a double-blind, 12-week trial in which they received on a daily basis buprenorphine (8 mg, s.l.) plus either desipramine (150 mg, p.o.), amantadine (300 mg, p.o.), or fluoxetine (60 mg, p.o. (cocaine.org)
The desipramine and amantadine groups appeared to have greater increases in opioid- and cocaine-free urines than the fluoxetine group. (cocaine.org)
These results suggest that desipramine and amantadine may facilitate greater opioid and cocaine abstinence than fluoxetine. (cocaine.org)

Desipramine is an oral antidepressant , a member of the tricyclic antidepressant (TCA) family which also includes amitriptyline ( Elavil , Endep ), and imipramine ( Tofranil ). (medicinenet.com)
We describe the unmasking of pheochromocytoma by desipramine therapy in a patient who showed no adverse effect while receiving amitriptyline intermittently over 9 years. (annals.org)

Desipramine interacts with other medications and drugs that slow the brain's function, such as alcohol , barbiturates , benzodiazepines , for example, lorazepam ( Ativan ), diazepam ( Valium ), temazepam ( Restoril ), oxazepam ( Serax ), clonazepam ( Klonopin ) as well as zolpidem ( Ambien ) and narcotics. (medicinenet.com)
Keep desipramine and all other medications out of the reach of children. (emedtv.com)
Generic desipramine is made by several manufacturers of generic medications. (emedtv.com)
Desipramine has been established as one of the first-line drugs in treating postherpetic neuralgia, however, due to its toxic profile physicians are often inclined to use second-line medications such as gabapentin. (statpearls.com)
As with the stimulant medications, numerous studies have reported an association between the use of desipramine and the risk of cardiovascular effects. (xhbv.com)

2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787194/7/Desipramine. (hopkinsguides.com)
TY - CONF AU - Marković, Olivera AU - Pešić, Miloš P. AU - Shah, Ankita V. AU - Serajuddin, Abu T.M. AU - Avdeef, Alex AU - Verbić, Tatjana PY - 2019 UR - http://cer.ihtm.bg.ac.rs/handle/123456789/3405 AB - The solution behavior of desipramine hydrochloride (DsHCl) in phosphate-buffered and unbuffered solutions is evidently complicated and only tentatively understood. (ac.rs)

Which drugs or supplements interact with desipramine? (medicinenet.com)
Desipramine and other TCAs should not be used with monoamine oxidase inhibiting drugs, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine ( Matulane ) since high fever , convulsions and even death can occur when these drugs are used together. (medicinenet.com)
The FDA Alert(s) below may be specifically about desipramine or relate to a group or class of drugs which include desipramine. (drugs.com)
Among the nonstimulant drugs used for adult ADHD with-out specific FDA approval, bupropion and desipramine appear most often in the literature. (xhbv.com)

The investigators have demonstrated that RISP (a medication that is both a DA D2 receptor antagonist, and a potent NE α2 receptor antagonist), in combination with the specific NE reuptake inhibitor desipramine, significantly decreases alcohol consumption in alcohol drinking rodents. (clinicaltrials.gov)

What are the side effects of desipramine? (medicinenet.com)
Cimetidine ( Tagamet ) can increase desipramine blood levels, possibly causing side effects. (medicinenet.com)
Dangerous side effects or death can occur when alcohol is combined with desipramine. (cigna.com)
The study will also compare the effects of risperidone as compared to risperidone plus desipramine on participants' symptoms and side effects. (clinicaltrials.gov)
As with any medicine, there are possible side effects with desipramine. (emedtv.com)
When desipramine side effects do occur, they are often minor and either require no treatment or can easily be treated by your healthcare provider. (emedtv.com)
Serious side effects of desipramine are less common. (emedtv.com)
Click Desipramine Side Effects to learn about specific side effects of the medication, including some of the more serious side effects that you should report to your healthcare provider. (emedtv.com)

Do not stop taking desipramine without talking to your doctor. (medlineplus.gov)
If you suddenly stop taking desipramine, you may experience withdrawal symptoms such as nausea, headache, and weakness. (medlineplus.gov)
Do not take an MAOI for at least 2 weeks after you stop taking desipramine. (cigna.com)

Desipramine is the major metabolite of imipramine and lofepramine. (wikipedia.org)
Desipramine, a metabolite of imipramine, has actions and uses similar to those of the parent compound and is as effective as imipramine in the treatment of mood disorders. (labcorp.com)

The observed effectiveness of desipramine in the treatment of ADHD was the basis for the development of the selective NRI atomoxetine and its use in ADHD. (wikipedia.org)

Do not use it if you had an allergic reaction to desipramine or a recent heart attack. (limamemorial.org)

Secondary amine TCAs like desipramine and nortriptyline have a lower risk of orthostatic hypotension than other TCAs, although desipramine can still cause moderate orthostatic hypotension. (wikipedia.org)

Treatment of rats with desipramine (DMI) 1 hour before the subcutaneous administration of methadone increased the intensity and prolonged the duration of methadone analgesia, as determined by the hot plate method. (aspetjournals.org)
An analysis of parotid salivary gland function with desipramine and age in female NIA Fischer 344 rats. (uzh.ch)

What is the dosage for desipramine? (medicinenet.com)
The likelihood of having suicidal thoughts while taking desipramine is the highest within the early months of treatment or whenever dosage increases. (therecoveryvillage.com)

In addition to these mechanisms, desipramine appears to downregulate beta-adrenergic receptors and serotonin receptors. (statpearls.com)
Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. (pharmacycode.com)

A hierarchical (gatekeeping) testing strategy to maintain a family-wise error rate will be adopted as the following: the first stage will compare desipramine or lidocaine individually to placebo with multiplicity-adjusted p-values. (clinicaltrials.gov)

The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with desipramine. (medlineplus.gov)
Desipramine may also be used for purposes not listed in this medication guide. (cigna.com)

We will study the clinical efficacy of four medical treatments for vulvar vestibulitis: topical lidocaine, oral desipramine, combined lidocaine and desipramine, and placebo cream and capsules. (clinicaltrials.gov)
It is hypothesized that the combined use of oral desipramine and topical lidocaine will be more therapeutically effective than either one by itself and better than placebo. (clinicaltrials.gov)
The Vulvar Vestibulitis Clinical Trial (VVCT) is a randomized, placebo-controlled, double-blinded clinical trial to study the clinical efficacy of four medical treatments for vulvar vestibulitis: 1) topical lidocaine, 2) oral desipramine, 3) combined lidocaine and desipramine, and 4) placebo cream and capsules. (clinicaltrials.gov)
The prognostic importance of baseline urines for cocaine was examined in a randomized, placebo-controlled, twelve-week clinical trial in 165 opioid- and cocaine-dependent patients who were treated with desipramine (DMI) in combination with buprenorphine (BUP) or methadone (Meth). (nih.gov)
The six-week, double-blind, placebo-controlled study assessed the differences in the reduction of ADHD symptoms in adults receiving desipramine or placebo. (xhbv.com)
The research suggests that 68% of subjects receiving desipramine responded to treatment, compared with none of the subjects who received placebo. (xhbv.com)

Desipramine hydrochloride is not approved for use in pediatric patients. (nih.gov)

Desipramine is the generic name of the drug and its INN and BAN, while desipramine hydrochloride is its USAN, USP, BAN, and JAN. Its generic name in French and its DCF are désipramine, in Spanish and Italian and its DCIT are desipramina, in German is desipramin, and in Latin is desipraminum. (wikipedia.org)

Your healthcare provider will want to see you often while you are taking desipramine, especially at the beginning of your treatment. (medlineplus.gov)
A literature review by Pérez-López et al indicated that in women with vestibulodynia, treatment with oral desipramine, with or without topical lidocaine, can lead to significant improvement in the Index of Sexual Satisfaction score, as assessed by the investigators through network meta-analyses. (medscape.com)
The primary hypothesis is that compared to treatment with risperidone, participants randomized to a combination of risperidone plus desipramine will have fewer days of drinking, as well as fewer days of heavy drinking. (clinicaltrials.gov)
Primary Objective: To determine the overall response rate (ORR) of small cell lung cancer and high-grade neuroendocrine tumors in patients during treatment with desipramine. (clinicalconnection.com)
Efficacy of desipramine can be established within the first 2 weeks of treatment of bulimia nervosa patients. (statpearls.com)
Desipramine has shown mild effectiveness in the treatment of ADHD. (statpearls.com)
One study is available examining the efficacy of desipramine in the treatment of adult ADHD. (xhbv.com)
Here we have investigated how hypothalamic neurons respond to treatment with antidepressants, including desipramine and sibutramine. (elsevier.com)

The influence of desipramine on thyroid hormone metabolism in rat brain. (aspetjournals.org)
The effect of the antidepressant desipramine (DMI) on the activities of the three iodothyronine deiodinase isoenzymes involved in the central metabolism of thyroid hormones were investigated in 11 brain regions and 3 peripheral tissues in the rat. (aspetjournals.org)
Increased analgesia and alterations in distribution and metabolism of methadone by desipramine in the rat. (aspetjournals.org)

Desipramine tends to be less sedating than other TCAs and tends to produce fewer anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision, and cognitive or memory impairments. (wikipedia.org)
Desipramine causes less sedation and constipation in comparison to other members of the group. (medscape.com)

The FDA approved desipramine in 1964. (medicinenet.com)
Desipramine was first approved by the FDA in 1964. (psycom.net)

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as desipramine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). (medlineplus.gov)
Desipramine elevates mood by raising the level of neurotransmitters in nerves of the brain. (medicinenet.com)
In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. (selfdecode.com)
In depressed individuals, desipramine exerts a positive effect on mood. (selfdecode.com)
Because of these dangers, people who are taking desipramine are advised to closely monitor their thoughts and behaviors, paying attention to abrupt changes in feelings or mood. (therecoveryvillage.com)

Chronic use of desipramine also leads to down-regulation of beta-adrenergic receptors in the cerebral cortex and sensitization of serotonergic receptors. (selfdecode.com)

Desipramine has the weakest antihistamine and anticholinergic effects of the TCAs. (wikipedia.org)
Whereas other TCAs are useful for treating insomnia, desipramine can cause insomnia as a side effect due to its activating properties. (wikipedia.org)

Overdoses of desipramine can cause life-threatening abnormal heart rhythms or seizures . (medicinenet.com)

Is desipramine available as a generic drug? (medicinenet.com)
Desipramine hydrochloride USP is an antidepressant drug of the tricyclic type, and is chemically: 5 H -Dibenz[ bƒ ]azepine-5-propanamine,10,11-dihydro- N -methyl-, monohydrochloride. (nih.gov)
Desipramine is a prescription drug. (healthline.com)
Wash-out of desipramine resulted in a rapid loss of enhanced maximum response to noradrenaline while the maximum response to K + did not show any decrease for up to 120 min after wash-out of drug. (springer.com)
There are nine drug master file entries for desipramine hydrochloride. (drugpatentwatch.com)
Desipramine hydrochloride USP is an antidepressant drug of the tricyclic type available as tablets of 10 mg, 25 mg, 50 mg, 75 mg, 100 mg or 150 mg for oral administration. (themedidex.com)
At that point, the levels of desipramine in the body are much lower than is detectable by typical drug tests. (therecoveryvillage.com)
Marković O, Pešić MP, Shah AV, Serajuddin AT, Avdeef A, Verbić T. Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates. (ac.rs)

Desipramine also possesses minor anticholinergic activity, through its affinity for muscarinic receptors. (selfdecode.com)

Desipramine may increase suicidal thoughts or behaviors. (healthline.com)
The biggest danger of desipramine is its link to heightened suicidal thoughts. (therecoveryvillage.com)
This is more of a problem with children and young adults taking desipramine, though you should talk to your doctor if you notice an increase in suicidal thoughts. (therecoveryvillage.com)

What is desipramine, and how does it work (mechanism of action)? (medicinenet.com)

The effects of desipramine on the total body plasma clearance (Cl) as well as the systemic fractional extraction (ER S ) of noradrenaline, dopamine, adrenaline, and isoprenaline, and on the pulmonary fractional extraction (ER p ) of dopamine and adrenaline were determined in the anaesthetized rabbit. (springer.com)
Desipramine reduced the Cl of noradrenaline (by 20%), but did not affect that of the other amines. (springer.com)

Desipramine hydrochloride is not a monoamine oxidase inhibitor (MAOI) and does not act primarily as a central nervous system stimulant. (nih.gov)

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Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo: effect of chronic antidepressant drug treatment. (1/521)

Neuronal uptake affects dynamic characteristics of heart rate response to sympathetic stimulation. (2/521)

Alpha 1-adrenergic receptor-mediated increase in the mass of phosphatidic acid and 1,2-diacylglycerol in ischemic rat heart. (3/521)

Enhancement of the serotonin-mediated acetylcholine release by repeated desmethylimipramine treatment in the hippocampus of freely moving rats. (4/521)

Electrochemical and electrophysiological characterization of neurotransmitter release from sympathetic nerves supplying rat mesenteric arteries. (5/521)

Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline- and methoxamine-evoked constriction of the dorsal hand vein. (6/521)

Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation. (7/521)

LLC-PK(1) cells stably expressing the human norepinephrine transporter: A functional model of carrier-mediated norepinephrine release in protracted myocardial ischemia. (8/521)

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Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo: effect of chronic antidepressant drug treatment. (1/521)

Neuronal uptake affects dynamic characteristics of heart rate response to sympathetic stimulation. (2/521)

Alpha 1-adrenergic receptor-mediated increase in the mass of phosphatidic acid and 1,2-diacylglycerol in ischemic rat heart. (3/521)

Enhancement of the serotonin-mediated acetylcholine release by repeated desmethylimipramine treatment in the hippocampus of freely moving rats. (4/521)

Electrochemical and electrophysiological characterization of neurotransmitter release from sympathetic nerves supplying rat mesenteric arteries. (5/521)

Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline- and methoxamine-evoked constriction of the dorsal hand vein. (6/521)

Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation. (7/521)

LLC-PK(1) cells stably expressing the human norepinephrine transporter: A functional model of carrier-mediated norepinephrine release in protracted myocardial ischemia. (8/521)

An analysis of parotid salivary gland function with desipramine and age in female NIA Fischer 344 rats. - Zurich Open...

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