Dermis. Medical search

A layer of vascularized connective tissue underneath the EPIDERMIS. The surface of the dermis contains innervated papillae. Embedded in or beneath the dermis are SWEAT GLANDS; HAIR FOLLICLES; and SEBACEOUS GLANDS.

The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

Remaining tissue from normal DERMIS tissue after the cells are removed.

The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).

Flat keratinous structures found on the skin surface of birds. Feathers are made partly of a hollow shaft fringed with barbs. They constitute the plumage.

Synthetic material used for the treatment of burns and other conditions involving large-scale loss of skin. It often consists of an outer (epidermal) layer of silicone and an inner (dermal) layer of collagen and chondroitin 6-sulfate. The dermal layer elicits new growth and vascular invasion and the outer layer is later removed and replaced by a graft.

The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.

Any inflammation of the skin.

Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.

The functions of the skin in the human and animal body. It includes the pigmentation of the skin.

Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.

Tumors or cancer of the SKIN.

A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.

An elevated scar, resembling a KELOID, but which does not spread into surrounding tissues. It is formed by enlargement and overgrowth of cicatricial tissue and regresses spontaneously.

The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.

Restoration of integrity to traumatized tissue.

A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).

Mutant strains of mice that produce little or no hair.

A class of Echinodermata characterized by long, slender bodies.

Mammalian pigment cells that produce MELANINS, pigments found mainly in the EPIDERMIS, but also in the eyes and the hair, by a process called melanogenesis. Coloration can be altered by the number of melanocytes or the amount of pigment produced and stored in the organelles called MELANOSOMES. The large non-mammalian melanin-containing cells are called MELANOPHORES.

Operative procedures performed on the SKIN.

Uptake of substances through the SKIN.

A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.

Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Congenital structural abnormalities of the skin.

The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.

The outer part of the hearing system of the body. It includes the shell-like EAR AURICLE which collects sound, and the EXTERNAL EAR CANAL, the TYMPANIC MEMBRANE, and the EXTERNAL EAR CARTILAGES.

Connective tissue comprised chiefly of elastic fibers. Elastic fibers have two components: ELASTIN and MICROFIBRILS.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Paired, segmented masses of MESENCHYME located on either side of the developing spinal cord (neural tube). Somites derive from PARAXIAL MESODERM and continue to increase in number during ORGANOGENESIS. Somites give rise to SKELETON (sclerotome); MUSCLES (myotome); and DERMIS (dermatome).

Small, sacculated organs found within the DERMIS. Each gland has a single duct that emerges from a cluster of oval alveoli. Each alveolus consists of a transparent BASEMENT MEMBRANE enclosing epithelial cells. The ducts from most sebaceous glands open into a HAIR FOLLICLE, but some open on the general surface of the SKIN. Sebaceous glands secrete SEBUM.

Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.

Mutant strains of rats that produce little or no hair. Several different homozygous recessive mutations can cause hairlessness in rats including rnu/rnu (Rowett nude), fz/fz (fuzzy), shn/shn (shorn), and nznu/nznu (New Zealand nude). Note that while NUDE RATS are often hairless, they are most characteristically athymic.

Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.

Material, usually gauze or absorbent cotton, used to cover and protect wounds, to seal them from contact with air or bacteria. (From Dorland, 27th ed)

The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.

Visible accumulations of fluid within or beneath the epidermis.

Disorders of increased melanin pigmentation that develop without preceding inflammatory disease.

Common name for two distinct groups of BIRDS in the order GALLIFORMES: the New World or American quails of the family Odontophoridae and the Old World quails in the genus COTURNIX, family Phasianidae.

Devices intended to replace non-functioning organs. They may be temporary or permanent. Since they are intended always to function as the natural organs they are replacing, they should be differentiated from PROSTHESES AND IMPLANTS and specific types of prostheses which, though also replacements for body parts, are frequently cosmetic (EYE, ARTIFICIAL) as well as functional (ARTIFICIAL LIMBS).

A genus of large SEA CUCUMBERS in the family Holothuriidae possessing thick body walls, a warty body surface, and microscopic ossicles.

Coloration of the skin.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.

The application of suitable drug dosage forms to the skin for either local or systemic effects.

Components of the extracellular matrix consisting primarily of fibrillin. They are essential for the integrity of elastic fibers.

A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.

Mucoid states characterized by the elevated deposition and accumulation of mucin (mucopolysaccharides) in dermal tissue. The fibroblasts are responsible for the production of acid mucopolysaccharides (GLYCOSAMINOGLYCANS) in the ground substance of the connective tissue system. When fibroblasts produce abnormally large quantities of mucopolysaccharides as hyaluronic acid, chondroitin sulfate, or heparin, they accumulate in large amounts in the dermis.

Loose connective tissue lying under the DERMIS, which binds SKIN loosely to subjacent tissues. It may contain a pad of ADIPOCYTES, which vary in number according to the area of the body and vary in size according to the nutritional state.

That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.

The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.

A vascular connective tissue formed on the surface of a healing wound, ulcer, or inflamed tissue. It consists of new capillaries and an infiltrate containing lymphoid cells, macrophages, and plasma cells.

Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.

A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.

The surgical removal of the inner contents of the eye, leaving the sclera intact. It should be differentiated from ORBIT EVISCERATION which removes the entire contents of the orbit, including eyeball, blood vessels, muscles, fat, nerve supply, and periosteum.

A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.

The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.

A nonspecific term used to denote any cutaneous lesion or group of lesions, or eruptions of any type on the leg. (From Stedman, 25th ed)

Skin diseases caused by ARTHROPODS; HELMINTHS; or other parasites.

Any horny growth such as a wart or callus.

HYALURONAN-containing proteoglycans found in the EXTRACELLULAR MATRIX of a variety of tissues and organs. Several versican isoforms exist due to multiple ALTERNATIVE SPLICING of the versican MESSENGER RNA.

A nevus containing melanin. The term is usually restricted to nevocytic nevi (round or oval collections of melanin-containing nevus cells occurring at the dermoepidermal junction of the skin or in the dermis proper) or moles, but may be applied to other pigmented nevi.

A ready-made or custom-made prosthesis of glass or plastic shaped and colored to resemble the anterior portion of a normal eye and used for cosmetic reasons. It is attached to the anterior portion of an orbital implant (ORBITAL IMPLANTS) which is placed in the socket of an enucleated or eviscerated eye. (From Dorland, 28th ed)

A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

A chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected.

A chronic inflammatory mucocutaneous disease usually affecting the female genitalia (VULVAR LICHEN SCLEROSUS) and BALANITIS XEROTICA OBLITERANS in males. It is also called white spot disease and Csillag's disease.

Highly keratinized processes that are sharp and curved, or flat with pointed margins. They are found especially at the end of the limbs in certain animals.

A heterogeneous group of autosomally inherited COLLAGEN DISEASES caused by defects in the synthesis or structure of FIBRILLAR COLLAGEN. There are numerous subtypes: classical, hypermobility, vascular, and others. Common clinical features include hyperextensible skin and joints, skin fragility and reduced wound healing capability.

A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.

A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.

Methods of preparing tissue for examination and study of the origin, structure, function, or pathology.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

An inherited disorder of connective tissue with extensive degeneration and calcification of ELASTIC TISSUE primarily in the skin, eye, and vasculature. At least two forms exist, autosomal recessive and autosomal dominant. This disorder is caused by mutations of one of the ATP-BINDING CASSETTE TRANSPORTERS. Patients are predisposed to MYOCARDIAL INFARCTION and GASTROINTESTINAL HEMORRHAGE.

The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.

The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.

Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.

A group of dermatoses with distinct morphologic features. The primary lesion is most commonly a papule, usually erythematous, with a variable degree of scaling on the surface. Plaques form through the coalescing of primary lesions.

A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.

Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).

A diffuse, non-pitting induration of the skin of unknown etiology that occurs most commonly in association with diabetes mellitus, predominantly in females. It typically begins on the face or head and spreads to other areas of the body, sometimes involving noncutaneous tissues. Often it is preceded by any of various infections, notably staphylococcal infections. The condition resolves spontaneously, usually within two years of onset. (From Dorland, 27th ed)

Sweat-producing structures that are embedded in the DERMIS. Each gland consists of a single tube, a coiled body, and a superficial duct.

The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).

Diseases of the skin with a genetic component, usually the result of various inborn errors of metabolism.

Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.

A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.

The prevention of access by infecting organisms to the locus of potential infection.

A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

The middle germ layer of an embryo derived from three paired mesenchymal aggregates along the neural tube.

A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.

The rear surface of an upright primate from the shoulders to the hip, or the dorsal surface of tetrapods.

Agents that soften, separate, and cause desquamation of the cornified epithelium or horny layer of skin. They are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

A vascular, horny neoplasm of the skin characterized by TELANGIECTASIS and secondary epithelial changes including acanthosis and hyperkeratosis.

A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.

An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.

Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.

A chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis.

The mechanical planing of the SKIN with sand paper, emery paper, or wire brushes, to promote reepithelialization and smoothing of skin disfigured by ACNE scars or dermal NEVI.

Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, double-blind, placebo-controlled trial. (1/1009)

OBJECTIVE: To determine whether interferon-alpha (IFNalpha) reduces the severity of skin involvement in early (<3 years) diffuse scleroderma. METHODS: In a randomized, placebo-controlled, double-blind trial, 35 patients with early scleroderma received subcutaneous injections of either IFNalpha (13.5 x 10(6) units per week in divided doses) or indistinguishable placebo. Outcomes assessed were the modified Rodnan skin score, as determined by a single observer at baseline, 6 months, and 12 months, as well as data on renal, cardiac, and lung function. Pre- and posttreatment skin biopsy samples were analyzed and blood was obtained for assessment of procollagen peptide levels. RESULTS: There were 11 withdrawals from the IFNalpha group and 3 from the placebo group due to either toxicity, lack of efficacy, or death. In the intent-to-treat analysis, there was a greater improvement in the skin score in the placebo group between 0 and 12 months (mean change IFNalpha -4.7 versus placebo -7.5; P = 0.36). There was also a greater deterioration in lung function in patients receiving active therapy, as assessed by either the forced vital capacity (mean change IFNalpha -8.2 versus placebo +1.3; P = 0.01) or the diffusing capacity for carbon monoxide (mean change IFNalpha -9.3 versus placebo +4.7; P = 0.002). Skin biopsy showed no significant decrease in collagen synthesis in the IFNalpha group, and no significant differences in the levels of procollagen peptides were seen between the 2 groups. CONCLUSION: This study suggests that IFNalpha is of no value in the treatment of scleroderma, and that it may in fact be deleterious. (+info)

Skin morphology and its role in thermoregulation in mole-rats, Heterocephalus glaber and Cryptomys hottentotus. (2/1009)

The skin structure of 2 Bathyergid rodents, the naked mole-rat (Heterocephalus glaber) and the common mole-rat (Cryptomys hottentotus) is compared, to investigate whether thermoregulatory differences may be attributed to different skin features. Histological and ultrastructural studies of the dorsal skin of these closely related species show morphological and structural similarities but differences in the degree of skin folding, thickness of the integument and dermal infrastructure were evident. The skin of the common mole-rat conforms with expected morphological/histological arrangements that are commonly found in mammalian skin. Many features of the skin of the naked mole-rat, such as the lack of an insulating layer and the loosely folded morphological arrangement contribute to poikilothermic responses to changing temperatures of this mammal. Further evidence for poikilothermy in the naked mole-rat is indicated by the presence of pigment containing cells in the dermis, rather than the epidermis, as commonly occurs in homeotherms. Lack of fur is compensated by a thicker epidermal layer and a marked reduction in sweat glands. Differences in skin morphology thus contribute substantially to the different thermoregulatory abilities of the 2 Bathyergids. The skin morphology is related to the poor thermoinsulatory ability of the animals while simultaneously facilitating heat transfer from the environment to the animal by thigmothermy and/or other behavioural means. (+info)

Multiple mechanisms contribute to the avoidance of avian epidermis by sensory axons. (3/1009)

In birds, sensory innervation of skin is restricted to dermis, with few axons penetrating into the epidermis. This pattern of innervation is maintained in vitro, where sensory neurites avoid explants of epidermis but grow readily on dermis. We have used this coculture paradigm to investigate the mechanisms that impede innervation of avian epidermis. The lack of epidermal innervation in birds has been attributed to diffusible chondroitin sulfate proteoglycans (CSPGs) secreted by the epidermis, although direct experimental evidence is weak. We found that elimination of CSPG function with either chondroitinase or neutralizing antibodies did not promote growth of DRG neurites onto epidermis in vitro, indicating that CSPGs alone are not responsible for preventing epidermal innervation. Moreover, the failure of sensory neurites to invade epidermis is not due exclusively to soluble chemorepulsive factors, since sensory neurites also avoid dead epidermis. This inhibition can be overridden, however, by coating epidermis with the growth-promoting molecule laminin, but only if the tissue is killed first. Epidermal innervation of laminin-coated epidermis is even more robust when CSPGs are also eliminated. Thus, the absence of growth-promoting or permissive molecules, such as laminin, may contribute to the failure of sensory neurites to invade avian epidermis. Together these results show that the inhibitory character of avian epidermis is complex. Cell- or matrix-associated CSPGs clearly contribute to the inhibition, but are not solely responsible. (+info)

Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction. (4/1009)

Chronic sun exposure results in photoaged skin with deep coarse wrinkles and loss of elasticity. We have examined the distribution and abundance of fibrillin-rich microfibrils, key structural components of the elastic fiber network, in photoaged and photoprotected skin. Punch biopsies taken from photoaged forearm and from photoprotected hip and upper inner arm of 16 subjects with a clinical range of photoaging were examined for fibrillin-1 and fibrillin-2 expression and microfibril distribution. In situ hybridization revealed decreased fibrillin-1 mRNA but unchanged fibrillin-2 mRNA levels in severely photoaged forearm biopsies relative to photoprotected dermal sites. An immunohistochemical approach demonstrated that microfibrils at the dermal-epidermal junction were significantly reduced in moderate to severely photoaged forearm skin. Confocal microscopy revealed that the papillary dermal microfibrillar network was truncated and depleted in photoaged skin. These studies highlight that the fibrillin-rich microfibrillar network associated with the upper dermis undergoes extensive remodeling following solar irradiation. These changes may contribute to the clinical features of photoaging, such as wrinkle formation and loss of elasticity. (+info)

Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. (5/1009)

Skin appendages, such as hair, develop as a result of complex reciprocal signaling between epithelial and mesenchymal cells. These interactions are not well understood at the molecular level. Platelet-derived growth factor-A (PDGF-A) is expressed in the developing epidermis and hair follicle epithelium, and its receptor PDGF-Ralpha is expressed in associated mesenchymal structures. Here we have characterized the skin and hair phenotypes of mice carrying a null mutation in the PDGF-A gene. Postnatal PDGF-A-/- mice developed thinner dermis, misshapen hair follicles, smaller dermal papillae, abnormal dermal sheaths and thinner hair, compared with wild-type siblings. BrdU labeling showed reduced cell proliferation in the dermis and in the dermal sheaths of PDGF-A-/- skin. PDGF-A-/- skin transplantation to nude mice led to abnormal hair formation, reproducing some of the features of the skin phenotype of PDGF-A-/- mice. Taken together, expression patterns and mutant phenotypes suggest that epidermal PDGF-A has a role in stimulating the proliferation of dermal mesenchymal cells that may contribute to the formation of dermal papillae, mesenchymal sheaths and dermal fibroblasts. Finally, we show that sonic hedgehog (shh)-/- mouse embryos have disrupted formation of dermal papillae. Such embryos fail to form pre-papilla aggregates of postmitotic PDGF-Ralpha-positive cells, suggesting that shh has a critical role in the assembly of the dermal papilla. (+info)

Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism. (6/1009)

PURPOSE: The vasoactive effects of propionyl-L-carnitine (PLC) on human arteries, including endothelial and smooth muscle cell influences, were studied. METHODS: Small (less than 200 microm) subcutaneous fat arteries (n = 19), obtained from human patients undergoing vascular surgery, were dissected and mounted in an arteriograph system that allowed measurement of lumen diameter and control of transmural pressure. To investigate the role of the endothelium, arteries were compared intact, intact and in the presence of either 0.3 mmol/L nitro-L-arginine (an inhibitor of nitric oxide synthesis) or 10 micromol/L indomethacin (an inhibitor of prostaglandin synthesis), or denuded of endothelium. After a 1-hour equilibration at a pressure of 50 mm Hg, arteries were precontracted 50% with an intermediate concentration of norepinephrine, and clinically relevant concentrations of PLC (0.1 to 100 micromol/L) were cumulatively added to the bath while the lumen diameter was continually measured. RESULTS: Intact arteries dose-dependently dilated to PLC, with the half maximal dilation occurring at 2.9 +/- 1.2 micromol/L, increasing diameter 91% +/- 5% at 100 micromol/L. In contrast, PLC had significantly less effect on deendothelialized arteries, increasing diameter only 24% +/- 11% at 100 micromol/L (P <.01 vs. intact). This indicates the endothelial dependency of this compound. Blockade of nitric oxide did not inhibit this vasodilation, with the half-maximal response occurring at 8.6 +/- 7 micromol/L, increasing diameter 85% +/- 8% at 100 micromol/L ( P >.05 vs. intact). However, this vasodilation was significantly diminished in the presence of indomethacin, which dilated arteries only 53% +/- 18% at 100 micromol/L (P <.01 vs. intact; P >.05 vs. denuded). CONCLUSION: PLC is an endothelium-dependent vasodilator, the mechanism of which is partially mediated by prostaglandin synthesis, not nitric oxide. The beneficial effects of this compound may, in part, be related to vasodilation and enhanced blood flow. (+info)

Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis. (7/1009)

Matrix metalloproteinase (MMP) plays an important role in extracellular matrix degradation associated with cancer invasion. An expression of MMP-1 (interstitial collagenase), MMP-2 (72-kDa type IV collagenase) and MMP-3 (stromelysin-1) was investigated in squamous cell carcinoma (SCC) and its precancerous condition, actinic keratosis (AK), using in situ hybridization techniques. MMP-1 mRNA was detected in tumour cells and/or in stromal cells in all cases of SCC, four of six AKs adjacent to SCC and four of 16 AKs. MMP-2 and MMP-3 mRNAs were detected in SCC but not in AK. The expression of MMP-3 correlated to that of MMP-1 (P = 0.03) localized at the tumour mass and stroma of the invasive area, while MMP-2 mRNA was detected widely throughout the stroma independent of MMP-1 expression. Our results indicated that the expression of MMP-1, -2 and -3 showed different localization patterns, suggesting a unique role of each MMP in tumour progression. Moreover, MMP-1 expression could be an early event in the development of SCC, and AK demonstrating MMP-1 mRNA, might be in a more advanced dysplastic state, progressing to SCC. (+info)

IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity. (8/1009)

During wound healing, fibroblasts are recruited from the surrounding tissue to accomplish repair. The requisite migration and proliferation of the fibroblasts is promoted by growth factors including those that activate the epidermal growth factor receptor (EGFR). Counterstimulatory factors in wound fluid are postulated to limit this response; among these factors is the ELR-negative CXC chemokine, interferon inducible protein-10 (IP-10). We report here that IP-10 inhibited EGF- and heparin-binding EGF-like growth factor-induced Hs68 human dermal fibroblast motility in a dose-dependent manner (to 52% and 44%, respectively, at 50 ng/ml IP-10), whereas IP-10 had no effect on either basal or EGFR-mediated mitogenesis (96 +/- 15% at 50 ng/ml). These data demonstrate for the first time a counterstimulatory effect of IP-10 on a specific induced fibroblast response, EGFR-mediated motility. To define the molecular basis of this negative transmodulation of EGFR signaling, we found that IP-10 did not adversely impact receptor or immediate postreceptor signaling as determined by tyrosyl phosphorylation of EGFR and two major downstream effectors phospholipase C-gamma and erk mitogen-activated protein kinases. Morphological studies suggested which biophysical steps may be affected by demonstrating that IP-10 treatment resulted in an elongated cell morphology reminiscent of failure to detach the uropod; in support of this, IP-10 pretreatment inhibited EGF-induced cell detachment. These data suggested that calpain activity may be involved. The cell permeant agent, calpain inhibitor I, limited EGF-induced motility and de-adhesion similarly to IP-10. IP-10 also prevented EGF- induced calpain activation (reduced by 71 +/- 7%). That this inhibition of EGF-induced calpain activity was secondary to IP-10 initiating a cAMP-protein kinase A-calpain cascade is supported by the following evidence: (a) the cell permeant analogue 8-(4-chlorophenylthio)-cAMP (CPT-cAMP) prevented EGF-induced calpain activity and motility; (b) other ELR-negative CXC chemokines, monokine induced by IFN-gamma and platelet factor 4 that also generate cAMP, inhibited EGF-induced cell migration and calpain activation; and (c) the protein kinase A inhibitor Rp-8-Br-cAMPS abrogated IP-10 inhibition of cell migration, cell detachment, and calpain activation. Our findings provide a model by which IP-10 suppresses EGF-induced cell motility by inhibiting EGF-induced detachment of the trailing edges of motile cells. (+info)

Perez, Dermis. Alberto Korda. Art Nexus. Mar.-May 2009. Che'd by Bruce Labruce [https://thequietus.com/articles/25636-bruce- ...

https://en.wikipedia.org/wiki/Alberto_Korda

Lizards and some frogs have somewhat similar osteoderms forming bony deposits in the dermis, but this is an example of ... Caecilians are unique among amphibians in having mineralized dermal scales embedded in the dermis between the furrows in the ...

https://en.wikipedia.org/wiki/Amphibian

These nevi represent abnormalities of collagen in the dermis, the deep layer of the skin.[8] ...

https://en.wikipedia.org/wiki/Mole_(skin_marking)

Dermis[edit]. Main article: Dermis. The dermis is the layer of skin beneath the epidermis that consists of connective tissue ... Dermis. The distribution of the bloodvessels in the skin of the sole of the foot. (Corium - TA alternate term for dermis - is ... The dermis provides tensile strength and elasticity to the skin through an extracellular matrix composed of collagen fibrils, ... The dermis is tightly connected to the epidermis through a basement membrane and is structurally divided into two areas: a ...

https://en.wikipedia.org/wiki/Skin

Dermis[edit]. Main article: Dermis. The dermis is the layer of skin between the epidermis and subcutaneous tissue, and ... the papillary dermis and the reticular dermis.[24] The superficial papillary dermis interdigitates with the overlying rete ... The subcutaneous tissue is a layer of fat between the dermis and underlying fascia.[5] This tissue may be further divided into ... Ulcer: An ulcer is a discontinuity of the skin exhibiting complete loss of the epidermis and often portions of the dermis and ...

https://en.wikipedia.org/wiki/Cutaneous_conditions

Dermis[edit]. Main article: Dermis. The dermis is the layer of skin beneath the epidermis that consists of connective tissue ... Tattoo ink is held in the dermis. Stretch marks, often from pregnancy and obesity, are also located in the dermis. ... The dermis is tightly connected to the epidermis by a basement membrane. It also harbors many nerve endings that provide the ... The subcutaneous tissue (also hypodermis and subcutis) is not part of the skin, but lies below the dermis of the cutis. Its ...

https://en.wikipedia.org/wiki/Human_skin

ISBN 1-898942-17-X. Shah, Idries (1980) [1970]. The Dermis Probe. London, UK: Octagon Press. p. 21. ISBN 0-86304-045-4. Shah, ... ISBN 1-85043-751-3.CS1 maint: extra text: authors list (link) Shah, Idries (1980) [1970]. The Dermis Probe. London, UK: Octagon ... The Dermis Probe ISBN 9781784790486 (1970-2016) Thinkers of the East: Studies in Experientialism ISBN 9781784790608 (1971-2016 ...

https://en.wikipedia.org/wiki/Idries_Shah

ISBN 978-0-7216-2921-6. "DermIS - Adenoma Sebaceum (information on the diagnosis)". www.dermis.net. Retrieved 2016-01-01. v t e ...

https://en.wikipedia.org/wiki/Adenoma_sebaceum

Acta Derm. Venereol. 78 (4): 319. doi:10.1080/000155598442098. PMID 9689318.. ...

https://en.wikipedia.org/wiki/Gluten-sensitive_enteropathy_associated_conditions

June 2004). "Content of oak moss allergens atranol and chloroatranol in perfumes and similar products". Contact Derm. 50 (6): ... Contact Derm. 52 (4): 216-25. doi:10.1111/j.0105-1873.2005.00563.x. PMID 15859994.. ...

https://en.wikipedia.org/wiki/Parfume

doi:10.4161/derm.24494. ISSN 1938-1972. PMC 3897598 . PMID 24494042.. *^ Lynch, David K.; Livingston, William Charles (2001). ... doi:10.4161/derm.20013.. *^ "Health effects of ultraviolet radiation" Archived 8 October 2016 at the Wayback Machine.. ...

https://en.wikipedia.org/wiki/UV

NSML at NIH/UW GeneTests Gorlin's syndrome II at Who Named It? DermAtlas 981603547 Dermnetnz DermIS. ...

https://en.wikipedia.org/wiki/Noonan_syndrome_with_multiple_lentigines

The dermis takes 3 mechanical states soft (S1), standard (S2) and stiff (S3).Animals without stimulation takes the standard ... Connective tissue, including dermis, tendons and ligaments, is one of four main animal tissues. Usual connective tissue does ... Starfish: body-wall dermis; walls of tube feet. Brittle stars: intervertebral ligaments; autotomy tendons of arm muscles. Sea ... Sea cucumbers: body-wall dermis. Early echinoderms were sessile organisms that fed on suspended particles carried by water ...

https://en.wikipedia.org/wiki/Catch_connective_tissue

Derm. 78: 483-487, 1958. Descargues P, Deraison C, Bonnart C, Kreft M, Kishibe M, Ishida-Yamamoto A, Elias P, Barrandon Y, ...

https://en.wikipedia.org/wiki/Netherton_syndrome

Derm. 5 (1): 30-38. doi:10.1111/j.1473-2165.2006.00220.x. PMID 17173569. Khachik, F., G.R. Beecher, M.B. Goli, and W.R. Lusby ( ...

https://en.wikipedia.org/wiki/Phytoene

Derm. Vener. (in Russian). 4: 64. Cited by Mitchell and Rook (1979), p. 693. Mitchell J, Rook A (1979). Botanical Dermatology: ...

https://en.wikipedia.org/wiki/Phytophotodermatitis

Derm. Syph. 181: 571-583, 1940. Blaszczyk M, Depaepe A, Nuytinck L, Glinska-Ferenz M, Jablonska S (2000). "Acrogeria of the ...

https://en.wikipedia.org/wiki/Acrogeria

Derm. 5 (1): 30-38. doi:10.1111/j.1473-2165.2006.00220.x. PMID 17173569.. ...

https://en.wikipedia.org/wiki/Phytofluene

Borelli, D (1961). "Hipotesis sobre ecologia de Paracoccidioides". Derm. Venez. 3: 130-132. Restrepo, M; et al. (1969). "Effect ...

https://en.wikipedia.org/wiki/Paracoccidioides_brasiliensis

Derm. Syph. Paris. 5: 598-606, 661-666. Balzer F, Ménétrier P (1885). "Étude sur un cas d'adénomes sébacés de la face et du ...

https://en.wikipedia.org/wiki/Félix_Balzer

Derm. Wschr. 89: 1163-1168. ...

https://en.wikipedia.org/wiki/Focal_facial_dermal_dysplasia

Derm. 87 (6): 694-7. doi:10.1111/1523-1747.ep12456630. PMID 2878051. Schewe C, Schewe T, Rohde E, Diezel W, Czarnetzki BM (1994 ...

https://en.wikipedia.org/wiki/Ammonium_bituminosulfonate

Verdich J (1981). "Granulomatous reaction in a red tattoo". Acta Derm Venereol. 61 (2): 176-7. PMID 6165203. Cairns RJ, Calnan ...

https://en.wikipedia.org/wiki/Tattoo_medical_issues

Acta Derm Venereol. 35 (Suppl 34): 3-368.. ...

https://en.wikipedia.org/wiki/Tuskegee_experiment

"Acta Derm Venereol. 95 (5): 516-524. doi:10.2340/00015555-2035. PMID 25520039.. .mw-parser-output cite.citation{font-style: ...

https://en.wikipedia.org/wiki/Radiation_

The Dermis Probe Followed by. The Magic Monastery First published in 1971, Thinkers of the East was one of several books of ...

https://en.wikipedia.org/wiki/Thinkers_of_the_East_–_Studies_in_Experientialism

Skin tumors, dermis}}. (none). Tumors: Skin neoplasm, dermis (C44/D23, 173/216). Dermatology templates Oncology templates. ...

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The dermis of a snake resides beneath the epidermis. The dermis of snakes is generally fibrous in nature, and not very ... Chromatophores in the dermis yield coloration when light shines through the corneal layer of the epidermis. There are many ... The hypodermis is below the dermis. This layer mainly stores fat. Molting is common, and results in the entire outer layer of ... These reside in the dermis. Iridocytes are also responsible for the iridescent appearance of many dark-colored snakes. Males ...

https://en.wikipedia.org/wiki/Snakeskin

The spirochetes multiply and migrate outward within the dermis. The host inflammatory response to the bacteria in the skin ... Hellerström S (1930). "Erythema chronicum migrans Afzelii". Acta Derm.-Venerol. (in German). 11: 315-21. Lenhoff C (1948). " ... "Spirochetes in aetiologically obscure diseases". Acta Derm.-Venerol. 28 (3): 295-324. PMID 18891989. Thyresson N (1949). "The ...

https://en.wikipedia.org/wiki/Lyme_disease

dermis (corium) (der-mis) n. the true skin: the thick layer of living tissue that lies beneath the epidermis.. -dermal adj. ... der·mis / ˈdərmis/ • n. technical the skin. ∎ Anat. the thick layer of living tissue below the epidermis that forms the true ... Beneath the dermis lies the subcutaneous tissue.. Cite this article Pick a style below, and copy the text for your bibliography ... dermis (corium; cutis) The thicker and innermost layer of the skin of vertebrates, the other layer being the epidermis. The ...

https://www.encyclopedia.com/medicine/anatomy-and-physiology/anatomy-and-physiology/dermis

The upper layer of the dermis beneath the epidermis, composed of dense irregular connective tissue[ncit,modified]. [ ... The upper layer of the dermis beneath the epidermis, composed of dense irregular connective tissue[ncit,modified]. ... papillary layer of dermis. Go to external page http://purl.obolibrary.org/obo/UBERON_0001992 Copy ... http://upload.wikimedia.org/wikipedia/commons/b/b4/Normal_Epidermis_and_Dermis_with_Intradermal_Nevus_10x.JPG ...

https://www.ebi.ac.uk/ols/ontologies/uberon/terms?iri=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FUBERON_0001992

The reticular dermis is the lower layer of the dermis, found under the papillary dermis, composed of dense irregular connective ... The papillary dermis is the uppermost layer of the dermis. It intertwines with the rete ridges of the epidermis and is composed ... The dermis is tightly connected to the epidermis through a basement membrane. Structural components of the dermis are collagen ... The dermal papillae are part of the uppermost layer of the dermis, the papillary dermis, and the ridges they form greatly ...

https://en.wikipedia.org/wiki/Dermis

Human dermis Small intestinal submucosa Bovine dermis Porcine dermis Human Demineralized Bone Matrix Equine pericardium Bovine ... Acellular dermis is a type of biomaterial derived from processing human or animal tissues to remove cells and retain portions ... Alloderm, an acellular dermis derived from the skin of donated cadavers, is used in reconstructive and dental surgeries. In ... In the case of Graftjacket, an allograft from human dermis, the matrix is quickly populated by host cells as vasculature. The ...

https://en.wikipedia.org/wiki/Acellular_dermis

El dermis es la capa de la piel que miente debajo de la epidermis y encima de la capa subcutánea. Es la capa más gruesa de la ... El dermis se comprende de dos capas: el dermis papilar y el dermis reticular. ... El dermis reticular es la capa más profunda y más gruesa del dermis, que miente encima de la capa subcutánea de la piel. ... Los vasos sanguíneos en el dermis llevan los alimentos a y desechan los residuos creados por el metabolismo dentro del dermis y ...

https://www.news-medical.net/health/What-is-the-Dermis-

Persons are in fact sensitized to some aminoacids that is shed from the surface of the puppys dermis. When a dog will begin ...

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The dermis contains sweat glands, hair follicles, and nerve endings. Learn about the dermis and find out how the malpighain ... The dermis is where the action is functionally. The dermis contains sweat glands, hair follicles (each with its own tiny little ... In direct contact with the dermis is the basal layer. If you have ever heard of a basal cell carcinoma (cancer), this is where ... It is in direct contact with the dermis, which feeds and supports it. The malpighian layer is our focus of attention actually, ...

https://health.howstuffworks.com/skin-care/beauty/sun-care/sunscreen3.htm

derm definition, variant of -dermatous, usually with nouns (melanoderm; pachyderm), or variant of -dermis (blastoderm; ectoderm ... derm. probably < French -derme (< Greek -dermos -skinned, adj. derivative of dérma skin; or < -dermis -dermis); or directly < ... variant of -dermatous, usually with nouns (melanoderm; pachyderm), or variant of -dermis (blastoderm; ectoderm; mesoderm). ...

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Low poly 3D dermis models for download, files in 3ds, max, c4d, maya, blend, obj, fbx with free format conversions, royalty- ...

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Porcine dermis dressing versus Bisgaard therapy for leg ulcers. Br Med J 1976; 2 :641 ... Porcine dermis dressing versus Bisgaard therapy for leg ulcers.. Br Med J 1976; 2 doi: https://doi.org/10.1136/bmj.2.6036.641-d ...

http://www.bmj.com/content/2/6036/641.4

Pinch skin grafting or porcine dermis in venous ulcers:. Br Med J (Clin Res Ed) 1987; 294 doi: https://doi.org/10.1136/bmj. ...

http://www.bmj.com/content/294/6583/1353.1

Thus, this work was undertaken to study age-related changes in the number of blood vessels in the human dermis. Blood vessels ... The number of dermal blood vessels positively stained either for von Willebrand factor or for CD31 in the dermis gradually ... The total number of fibroblasts in the dermis, as well as the portion of proliferating PCNA+ fibroblasts, also diminished with ... Age-related changes in the number of CD45+ cells in human dermis, Adv. Gerontol., 2012, vol. 25, no. 4, pp. 598-603.PubMed ...

https://link.springer.com/article/10.1134%2FS2079057015020058

... surgeons are electing to use acellular dermis to assist with tissue expander or implant-based primary breast reconstruction. Of ... What are the initial steps in breast reconstruction with acellular dermis?. How is the acellular dermis prepared for breast ... encoded search term (Breast Reconstruction With Acellular Dermis) and Breast Reconstruction With Acellular Dermis What to Read ... The acellular dermis used must be the proper size-that is, it should be just large enough to cover the inferior pole of tissue ...

https://emedicine.medscape.com/article/1851090-overview

... used options and get the best deals for Obagi Nu Derm Blend Fx 2 oz at the best online prices at eBay! Free shipping for many ... The Obagi Nu-Derm program is great for my skin. I use it morning and night. This is #5 which is a part of #1, 2, 3, 4 and 5. ... Obagi • Nu-Derm Clear Fx Skin Brightening Cream # 3 • 2oz • New • AUTHENTIC. ...

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Detailed dosage guidelines and administration information for Monistat-Derm (miconazole nitrate). Includes dose adjustments, ... If MONISTAT-DERM Cream is used in intertriginous areas, it should be applied sparingly and smoothed in well to avoid maceration ... Sufficient MONISTAT-DERM Cream should be applied to cover affected areas twice daily (morning and evening) in patients with ...

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KudoZ) Spanish to English translation of Ds Dp (abbreviations): superficial dermis, deep dermis [Medical Report - Medical ( ... superficial dermis, deep dermis. Explanation:. Ds: dermis superficial. Dp: dermis profunda. Rita Tepper. Local time: 08:13. ...

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PHOTOS: Derm Appointment. By Queerty Staff May 22, 2009 at 5:05pm. · 83 comments ...

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A disruptive physician isnt necessarily aggressive in an obviously obnoxious way. The disruption may come from behaving in a way that interferes with others work, not communicating across specialties or teams, or failing to give or receive effective feedback. Heres what you can do to avoid a disrespectful and non-professional environment. ...

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... Internationally acclaimed brand Clinique gives several high quality acne and cleansing products to ... Cleansing: Clinique Crystal krem acne derm opinie clear Skin System helps clear and prevent acne on face and body. With six ...

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For those new to Nu-Derm If you dont know about or arent using the Obagi Nu-Derm® System* yet, allow us to introduce you to ... For current Nu-Derm users. Have you heard of our Nu-Derm Continuum program? If youve been through the Nu-Derm system and want ... For those new to Nu-Derm. If you dont know about or arent using the Obagi Nu-Derm® System* yet, allow us to introduce you to ... Tip for Success: When you start the Nu-Derm system, take 1 minute to sign up for our New to Nu-Derm℠ email program. Youll ...

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DERM INK. Derm Ink is the go-to for tattoo aftercare. Offering non-greasy treatment for sensitive, recently inked skin Derm Ink ...

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arch(ie) , -ase , -ästhesie , -derm(ie) , -drom , -eder , -em , -erg(ie) , -fon(ie)/-phon(ie) , -gen , -gnosie , -gon(ie) , - ... derm(o)- , di-/dia-/diar- , dys- , ek-/ex- , ekto- , en-/endo-/em- , ep-/eph-/epi- , ergo- , erythr(o)- , eu-/ev- , exo- , ... 1] Canoo das Neoklassische Formativ derm. Worterweiterungen fremder Herkunft im Deutschen. Griechisch vorangestellt: a-/an-/ana ... Abgerufen von „https://de.wiktionary.org/w/index.php?title=derm-&oldid=6292400" ...

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Porcine Dermis, First Human Implantation Complete Implant Rounds Out Comprehensive Line of Biologic Solutions for Hernia Repair ... RTI Biologics®Launches Fortiva™ Porcine Dermis, First Human Implantation Complete. Implant Rounds Out Comprehensive Line of ... Fortiva porcine dermis is ready-to-use, requiring no rehydration or rinsing. Fortiva also aids in efficiency in the OR, with a ... Fortiva porcine dermis is a non-crosslinked acellular porcine dermal matrix intended for use as a soft tissue patch to ...

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Rate your experience with Blem-Derm topical on - WebMD including the side effects, drug interactions, effectiveness, ease of ...

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BarCampRDU Pre-Party Friday at Tylers Derm!. 8/3/2007 / Paul / 0 Comments ...

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The Brightening Derm Revival Mask is part of the SK-II Skin Brightening Products collection, which was designed to illuminate ... SK-IIs Brightening Derm Revival Mask is a clarifying and moistureizing sheet mask infused with skin-conditioning ingredients ...

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Awards-show makeup and skin-loving ingredients dont usually go hand in hand, but tonight, Adam Breuchaud, makeup artist to American Horror Story star Sarah Paulson, changed that. Instead of the usual full-coverage suspects, Breuchaud relied on the dermatologist-beloved brand Colorescience for Paulson

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Shop the latest collection of Gly Derm mens fashion from the most popular stores - all in one place. ... Find Gly Derm mens fashion at ShopStyle. ... We could not find many matches for: Gly Derm Mens Fashion Try ...

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DC Derm Docs is a member in the Wellness.com community where wellness-minded individuals write blogs, set goals, find health ... DC Derm Docs has been featured on ABC 7, NBC 4, FOX News, Self Magazine, Good Housekeeping and many other media outlets.Whether ... DC Derm Docs specializes in the art and science of beauty. Drs. Marilyn Berzin and Dale Isaacson have consistently been named ... youre planning a wedding, celebrating a birthday, or just want to pamper yourself, DC Derm Docs provides the latest and most ...

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The upper layer of the dermis beneath the epidermis, composed of dense irregular connective tissue[ncit,modified]. (ebi.ac.uk)
The dermis or corium is a layer of skin between the epidermis (with which it makes up the cutis) and subcutaneous tissues, that primarily consists of dense irregular connective tissue and cushions the body from stress and strain. (wikipedia.org)
It is divided into two layers, the superficial area adjacent to the epidermis called the papillary region and a deep thicker area known as the reticular dermis. (wikipedia.org)
The dermis is tightly connected to the epidermis through a basement membrane. (wikipedia.org)
The dermal papillae (DP) (singular papilla, diminutive of Latin papula, 'pimple') are small, nipple-like extensions (or interdigitations) of the dermis into the epidermis. (wikipedia.org)
The dermal papillae are part of the uppermost layer of the dermis, the papillary dermis, and the ridges they form greatly increase the surface area between the dermis and epidermis. (wikipedia.org)
Because the main function of the dermis is to support the epidermis, this greatly increases the exchange of oxygen, nutrients, and waste products between these two layers. (wikipedia.org)
El dermis es la capa de la piel que miente debajo de la epidermis y encima de la capa subcutánea. (news-medical.net)
El papel primario del dermis es soportar la epidermis y permitir a la piel prosperar. (news-medical.net)
Los vasos sanguíneos en el dermis llevan los alimentos a y desechan los residuos creados por el metabolismo dentro del dermis y de la epidermis, además de la ayuda regular la temperatura de la carrocería. (news-medical.net)
The dermis layer of skin is beneath the epidermis, and its main function is temperature regulation and blood supply. (reference.com)
The dermis is the layer below the epidermis and above the hypodermis. (laroche-posay.com)
This is a comprehensive study of the changes in major antioxidant enzymes and antioxidant molecules during intrinsic aging and photoaging processes in the epidermis and dermis of human skin in vivo. (thefreedictionary.com)
The skin of humans and other mammals is composed of two major layers: (1) epidermis (the more superficial layer) and (2) dermis (the deeper layer). (biology-online.org)
The papillary dermis is the layer of the dermis closer to the epidermis Its basic components include connective tissues, lymphatic plexuses, and blood vessels. (biology-online.org)
These papillae are small, nipple-like extensions of the dermis into the epidermis . (biology-online.org)
The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. (bioontology.org)
The blood vessels in the dermis provide nourishment and waste removal to its own cells as well as the Stratum basale of the epidermis. (wikidoc.org)
The papillae provide the dermis with a 'bumpy' surface that interdigitates with the epidermis, strengthening the connection between the two layers of skin. (wikidoc.org)

The reticular dermis is the lower layer of the dermis, found under the papillary dermis, composed of dense irregular connective tissue featuring densely-packed collagen fibers. (wikipedia.org)
The orientation of collagen fibers within the reticular dermis creates lines of tension called Langer's lines, which are of some relevance in surgery and wound healing. (wikipedia.org)
The reticular dermis is a dense irregular connective tissue with fibroblasts and densely packed collagen fibers, organized in intertwined fascicles. (shutterstock.com)
The dermis can be further divided into two major layers: the papillary dermis and the reticular dermis . (biology-online.org)
Compared with the reticular dermis , the papillary dermis is thinner and more superficial. (biology-online.org)

Acellular dermis is a type of biomaterial derived from processing human or animal tissues to remove cells and retain portions of the extracellular matrix (ECM). (wikipedia.org)
With increasing frequency, surgeons are electing to use acellular dermis to assist with tissue expander or implant-based primary breast reconstruction. (medscape.com)
[ 3 ] Several authors have reported favorable results for procedures involving acellular dermis, and rapid early expansion has led to improved cosmetic outcomes. (medscape.com)
Breuing first reported the use of human acellular dermis in implant-based breast reconstruction in 2005. (medscape.com)
[ 4 ] Not long after, Bindingnavele reported acellular dermis-assisted tissue expander-based reconstruction. (medscape.com)
In 2009, Nahabedian explored the use of acellular dermis in the context of postoperative irradiation. (medscape.com)
[ 11 ] This study addressed the increasingly widespread sentiment that acellular dermis affected complication rates in patients receiving postoperative radiation therapy and led other authors, such as Rawlani et al, to explore these effects further. (medscape.com)
Any woman who is a candidate for tissue expander or implant-based reconstruction is a potential candidate for the use of acellular dermis and should be informed of the option. (medscape.com)
Fortiva porcine dermis is a non-crosslinked acellular porcine dermal matrix intended for use as a soft tissue patch to reinforce soft tissue where weakness exists and for the surgical repair of damaged or ruptured soft tissue membranes. (aol.com)
To evaluate the use, indications, and short-term outcomes for human acellular dermis. (hindawi.com)
We retrospectively reviewed patients having human acellular dermis placed for ventral hernia repair from January 2008 through October 2009. (hindawi.com)
Although followup is limited, there remains a high recurrence rate associated with the use of human acellular dermis. (hindawi.com)
Due to this and the paucity of data associated with many of the biologic products, we evaluated our experience with the use of human acellular dermis, one of the most commonly used biologic grafts, its indications, and outcomes for use in ventral hernia repair. (hindawi.com)
Following Institutional Review Board approval, we retrospectively reviewed all patients having human acellular dermis placed for repair of ventral hernias from January 1, 2008 through October 31, 2009. (hindawi.com)

The dermis consists of fibrous connective tissue in which are embedded blood vessels, sensory nerve endings, and (in mammals) hair follicles, sebaceous glands, and sweat ducts. (encyclopedia.com)

Porcine dermis dressing versus Bisgaard therapy for leg ulcers. (bmj.com)
Porcine dermis. (bmj.com)
RTIX ) , a leading provider of orthopedic and other biologic implants, is pleased to announce the launch of its Fortiva™ porcine dermis implant at the Abdominal Wall Reconstruction (AWR) Conference in Washington, D.C., June 6-8. (aol.com)
RTI celebrated a milestone for Fortiva porcine dermis on May 23 when a patient in Missouri received a 10x16cm graft for an incisional hernia repair using a component separation technique. (aol.com)
Fortiva porcine dermis is ready-to-use, requiring no rehydration or rinsing. (aol.com)
Fortiva porcine dermis is sterilized through RTI's Tutoplast ® Tissue Sterilization Process, a validated chemical sterilization process that thoroughly penetrates tissue, removing antigenicity and inactivating pathogens. (aol.com)
The launch of Fortiva porcine dermis is a major milestone for RTI, as we now offer surgeons the most comprehensive biologic solutions in hernia repair from a provider they trust," said Brian K. Hutchison, RTI president and CEO. (aol.com)
Fortiva porcine dermis will be featured at the Component Separation lab station and Tutopatch bovine pericardium will be featured at the Minimally Invasive lab station. (aol.com)

I believe Dermira (DERM) will start improving from now on, because it looks like they hit their bottom, and they must have learned their mistakes. (fool.com)
Shares of Dermira, Inc. ( DERM ) hit a new high of $19.30 on Wednesday's trading before closing at $17.56. (rttnews.com)

L'Oreal's Revitalift Derm Intensive Hyaluronic Acid Serum is a dermatologist validated, highly-concentrated, anti-aging plumping hyaluronic acid serum that immediately hydrates and fills wrinkles in 2 weeks. (ulta.com)

Sufficient MONISTAT-DERM Cream should be applied to cover affected areas twice daily (morning and evening) in patients with tinea pedis, tinea cruris, tinea corporis, and cutaneous candidiasis, and once daily in patients with tinea versicolor. (drugs.com)
If MONISTAT-DERM Cream is used in intertriginous areas, it should be applied sparingly and smoothed in well to avoid maceration effects. (drugs.com)
Anti-wrinkle, antioxidant and antiradical, Pro-Derm Regenerating Cream has been formulated to moisturize and regenerate sensitive and couperose-prone skin. (essentialdayspa.com)
What conditions does Medi-Derm-L Cream treat? (webmd.com)
List Medi-Derm-L Cream side effects by likelihood and severity. (webmd.com)
What should I know regarding pregnancy, nursing and administering Medi-Derm-L Cream to children or the elderly? (webmd.com)
Does Medi-Derm-L Cream interact with other medications? (webmd.com)
Have you ever purchased Medi-Derm-L Cream? (webmd.com)
Rinse off cleaning foam and saturating natural cotton ball with the Clinique Acne Solutions Clarifying cream acne derm krem ulotka . (all4webs.com)

Blood and lymph vessels are contained within the dermis as well as hair follicles and sweat glands. (reference.com)

The number of dermal blood vessels positively stained either for von Willebrand factor or for CD31 in the dermis gradually decreased with age. (springer.com)
Like real skin, the e-dermis has an outer, epidermal layer and an inner, dermal layer. (hackaday.com)
Cyclin D1 was overexpressed primarily within the dermal-epidermal junction and/or papillary dermis in Spitz nevi, whereas cyclin D1-positive nevus cells were present throughout the lesion in most malignant melanomas. (thefreedictionary.com)
Dermal Revolution (DERM) is available to buy in pairs. (dermalrevolution.com)

The dermis has two sub-layers, including a papillary layer of thin collagen fibers and a reticular layer of thick collagen fibers. (reference.com)

TAMPA Fla. - The Florida State League announced on Thursday that Tampa Tarpons DH Dermis Garcia and RHP Miguel Yajure have been named to the 2019 FSL Post-Season All-Star Team. (milb.com)

More than 250 nurse practitioners, physician assistants and dermatologists from around the United States gathered at the DERM (Derm Education Foundation Essential Resource Meeting) 2016 annual meeting last week in Las Vegas. (modernmedicine.com)

DermIS.net is the largest dermatology information service available on the internet. (dermis.net)

Can be used before Derm Intensives 10% Vitamin C Serum. (ulta.com)

Cleansing: Clinique Crystal krem acne derm opinie clear Skin System helps clear and prevent acne on face and body. (dailystrength.org)

In the case of Graftjacket, an allograft from human dermis, the matrix is quickly populated by host cells as vasculature. (wikipedia.org)
Tutopatch™ bovine pericardium, Tutomesh™ fenestrated bovine pericardium and Cortiva™ allograft dermis launched in March . (aol.com)

Pro-Derm, the premium skincare and beauty brand, recently expanded its product portfolio with the introduction of the new Pro-Derm Hydrogel. (trendhunter.com)
According to its varied clientele who have expressed having done countless online searches for this type of service, Bella Dermis Skin Care LLC is the only skincare studio in the Tampa Bay Area to perform Intimate Skin Bleaching and uses Safe, natural, hydroquinone-free products. (thefreedictionary.com)

OBJECTIVE To assess the effect of a tissue-engineered human dermis (Dermagraft) in healing diabetic foot ulcers. (diabetesjournals.org)

Although identification of larvae by a biopsy is recommended for definitive diagnosis, such identification was possible in only 16 cases, including three in which the worms were easily excised after their outward migration to the dermis as a consequence of treatment with albendazole as has been recommended (6). (thefreedictionary.com)

El dermis reticular es la capa más profunda y más gruesa del dermis, que miente encima de la capa subcutánea de la piel. (news-medical.net)

That is where the e-dermis comes in, conveying information to the amputee by stimulating peripheral nerves in the arm, making the so-called phantom limb come to life. (disabled-world.com)

The dermis is home to the sebaceous glands, which secrete oil to help skin keep its smooth texture. (reference.com)

Pro-Derm Gentle Cleanser, with an optimal acid pH of 4,5, maintains the skin s integrity and is specially formulated to maximize the results of all Pro-Derm products. (essentialdayspa.com)

Nerve endings, collagen and elastin are also found in the dermis. (reference.com)
Proteins: The protein component of the dermis is largely made up of collagen and elastin. (thefreedictionary.com)

The dermis is composed of three major types of cells: fibroblasts, macrophages, and mast cells. (wikipedia.org)
The total number of fibroblasts in the dermis, as well as the portion of proliferating PCNA+ fibroblasts, also diminished with age. (springer.com)

Acne Derm jak dawkować? (dailystrength.org)
Vivant Skin Care Derm-A-Gel (Level I) gives your skin a revitalizing dose of Vitamin A that diminishes the appearance of wrinkles, acne and dark spots as it promotes firmness and elasticity. (secure-booker.com)
Skip ahead to see the 9 best acne-derm 20 and 3 worst acne products now. (all4webs.com)

Thus, this work was undertaken to study age-related changes in the number of blood vessels in the human dermis. (springer.com)
Inspired by human biology, the e-dermis enables its user to sense a continuous spectrum of tactile perceptions, from light touch to noxious or painful stimulus. (disabled-world.com)
The team created a "neuromorphic model" mimicking the touch and pain receptors of the human nervous system, allowing the e-dermis to electronically encode sensations just as the receptors in the skin would. (disabled-world.com)
The e-dermis technology could be used to make robotic systems more human, and it could also be used to expand or extend to astronaut gloves and space suits, Osborn says. (disabled-world.com)

Derm consult? (studentdoctor.net)
I have never seriously heard of an INPATIENT derm consult before. (studentdoctor.net)
I feel like I know a lot more derm after that rotation but those guys/gals know a ton so just call the consult. (studentdoctor.net)

These protein fibers give the dermis its properties of strength, extensibility, and elasticity. (wikipedia.org)

The reticular region is usually much thicker than the overlying papillary dermis. (wikipedia.org)

Made of fabric and rubber laced with sensors to mimic nerve endings, e-dermis electronic skin will enable amputees to perceive through prosthetic fingertips. (disabled-world.com)
When layered on top of prosthetic hands, this e-dermis brings back a real sense of touch through the fingertips. (disabled-world.com)
This is interesting and new," Osborn said, "because now we can have a prosthetic hand that is already on the market and fit it with an e-dermis that can tell the wearer whether he or she is picking up something that is round or whether it has sharp points. (disabled-world.com)

Apart from these cells, the dermis is also composed of matrix components such as collagen (which provides strength), elastin (which provides elasticity), and extrafibrillar matrix, an extracellular gel-like substance primarily composed of glycosaminoglycans (most notably hyaluronan), proteoglycans, and glycoproteins. (wikipedia.org)

Speak with your skin care physician to get all the facts about Nu-Derm and to see if it might be the right system to help you finally achieve the look you want! (obagi.com)
Print out the personalized suggestions you get from Nu-Derm Continuum and take it to your skin care physician. (obagi.com)

The Brightening Derm Revival Mask is part of the SK-II Skin Brightening Products collection, which was designed to illuminate and brighten skin's appearance by diminishing the look of dark spots, revealing a more radiant complexion. (sephora.com)
Obagi Nu-derm products are doing something no other product has ever been able to do to my face. (hubpages.com)

SK-II's Brightening Derm Revival Mask is a clarifying and moistureizing sheet mask infused with skin-conditioning ingredients that help transform your complexion. (sephora.com)

Made of fabric and rubber laced with sensors to mimic nerve endings, e-dermis recreates a sense of touch as well as pain by sensing stimuli and relaying the impulses back to the peripheral nerves. (disabled-world.com)

The papillary dermis is the uppermost layer of the dermis. (wikipedia.org)
In direct contact with the dermis is the basal layer . (howstuffworks.com)
What Is the Function of the Dermis Layer of Cells? (reference.com)
Researchers at Johns Hopkins university have spent the last year testing out their concept of an e-dermis -a multi-layer approach to expanding the utility of artificial limbs that can detect the curvature and sharpness of objects. (hackaday.com)

More than 30,000 patients have turned to First Derm , a TalkSpace -esque app that pairs you with a dermatologist. (yahoo.com)

Anatomy32

Organisms6

Diseases37

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes9

Disciplines and Occupations1

Technology, Industry, Agriculture1

Health Care2

Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, double-blind, placebo-controlled trial. (1/1009)

Skin morphology and its role in thermoregulation in mole-rats, Heterocephalus glaber and Cryptomys hottentotus. (2/1009)

Multiple mechanisms contribute to the avoidance of avian epidermis by sensory axons. (3/1009)

Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction. (4/1009)

Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. (5/1009)

Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism. (6/1009)

Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis. (7/1009)

IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity. (8/1009)

Dermis

Skin

Acellular Dermis

Epidermis

Feathers

Skin, Artificial

Skin Aging

Skin Diseases

Dermatitis

Keratinocytes

Skin Physiological Phenomena

Langerhans Cells

Skin Neoplasms

Hair Follicle

Cicatrix, Hypertrophic

Skin Transplantation

Wound Healing

Keloid

Collagen

Mice, Hairless

Sea Cucumbers

Melanocytes

Dermatologic Surgical Procedures

Skin Absorption

Psoriasis

Fibroblasts

Skin Abnormalities

Injections, Intradermal

Ear, External

Elastic Tissue

Immunohistochemistry

Somites

Sebaceous Glands

Connective Tissue

Rats, Hairless

Hyperpigmentation

Occlusive Dressings

Chick Embryo

Blister

Melanosis

Quail

Artificial Organs

Holothuria

Skin Pigmentation

Biopsy

Erythema

Administration, Cutaneous

Microfibrils

Hair

Mucinoses

Subcutaneous Tissue

Ultraviolet Rays

Facial Dermatoses

Ear

Granulation Tissue

Microscopy, Electron

Facial Neoplasms

Scleroderma, Localized

Eye Evisceration

Basement Membrane

Cicatrix

Leg Dermatoses

Skin Diseases, Parasitic

Keratosis

Skin Ulcer

Versicans

Nevus, Pigmented

Eye, Artificial

Dermatitis, Atopic

Mycosis Fungoides

Lichen Sclerosus et Atrophicus

Hoof and Claw

Ehlers-Danlos Syndrome

Dermatitis, Allergic Contact

Dermatitis, Contact

Histological Techniques

Cells, Cultured

Pseudoxanthoma Elasticum

Morphogenesis

Administration, Topical