Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
Depression in POSTPARTUM WOMEN, usually within four weeks after giving birth (PARTURITION). The degree of depression ranges from mild transient depression to neurotic or psychotic depressive disorders. (From DSM-IV, p386)
The decrease in neuronal activity (related to a decrease in metabolic demand) extending from the site of cortical stimulation. It is believed to be responsible for the decrease in cerebral blood flow that accompanies the aura of MIGRAINE WITH AURA. (Campbell's Psychiatric Dictionary, 8th ed.)
Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.
A persistent activity-dependent decrease in synaptic efficacy between NEURONS. It typically occurs following repeated low-frequency afferent stimulation, but it can be induced by other methods. Long-term depression appears to play a role in MEMORY.
Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Persistent and disabling ANXIETY.
Check list, usually to be filled out by a person about himself, consisting of many statements about personal characteristics which the subject checks.
A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication.
Stress wherein emotional factors predominate.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Compounds that specifically inhibit the reuptake of serotonin in the brain.
A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The feeling-tone accompaniment of an idea or mental representation. It is the most direct psychic derivative of instinct and the psychic representative of the various bodily changes by means of which instincts manifest themselves.
Elements of limited time intervals, contributing to particular results or situations.
The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Assessment of psychological variables by the application of mathematical procedures.
Chronically depressed mood that occurs for most of the day more days than not for at least 2 years. The required minimum duration in children to make this diagnosis is 1 year. During periods of depressed mood, at least 2 of the following additional symptoms are present: poor appetite or overeating, insomnia or hypersomnia, low energy or fatigue, low self esteem, poor concentration or difficulty making decisions, and feelings of hopelessness. (DSM-IV)
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)
Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
A directed conversation aimed at eliciting information for psychiatric diagnosis, evaluation, treatment planning, etc. The interview may be conducted by a social worker or psychologist.
A selective serotonin uptake inhibitor that is used in the treatment of depression.
The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)
Care which provides integrated, accessible health care services by clinicians who are accountable for addressing a large majority of personal health care needs, developing a sustained partnership with patients, and practicing in the context of family and community. (JAMA 1995;273(3):192)
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
A state of harmony between internal needs and external demands and the processes used in achieving this condition. (From APA Thesaurus of Psychological Index Terms, 8th ed)
Those occurrences, including social, psychological, and environmental, which require an adjustment or effect a change in an individual's pattern of living.
Standardized tests designed to measure abilities, as in intelligence, aptitude, and achievement tests, or to evaluate personality traits.
The act of killing oneself.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Tactical warfare using incendiary mixtures, smokes, or irritant, burning, or asphyxiating gases.
Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies. (Campbell's Psychiatric Dictionary, 9th ed.)
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
Use of electric potential or currents to elicit biological responses.
Electrically induced CONVULSIONS primarily used in the treatment of severe AFFECTIVE DISORDERS and SCHIZOPHRENIA.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A risk factor for suicide attempts and completions, it is the most common of all suicidal behavior, but only a minority of ideators engage in overt self-harm.
Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.
A broad class of substances encompassing all those that do not include carbon and its derivatives as their principal elements. However, carbides, carbonates, cyanides, cyanates, and carbon disulfide are included in this class.
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.
Support systems that provide assistance and encouragement to individuals with physical or emotional disabilities in order that they may better cope. Informal social support is usually provided by friends, relatives, or peers, while formal assistance is provided by churches, groups, etc.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
Those disorders that have a disturbance in mood as their predominant feature.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The mating of plants or non-human animals which are closely related genetically.
A class of traumatic stress disorders with symptoms that last more than one month. There are various forms of post-traumatic stress disorder, depending on the time of onset and the duration of these stress symptoms. In the acute form, the duration of the symptoms is between 1 to 3 months. In the chronic form, symptoms last more than 3 months. With delayed onset, symptoms develop more than 6 months after the traumatic event.
Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Child with one or more parents afflicted by a physical or mental disorder.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A serotonin uptake inhibitor that is effective in the treatment of depression.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
Social and economic factors that characterize the individual or group within the social structure.
Chemicals that are used to cause the disturbance, disease, or death of humans during WARFARE.
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
Those affective states which can be experienced and have arousing and motivational properties.
The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
The unsuccessful attempt to kill oneself.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The determination and evaluation of personality attributes by interviews, observations, tests, or scales. Articles concerning personality measurement are considered to be within scope of this term.
Evaluation of the level of physical, physiological, or mental functioning in the older population group.
Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
A person's view of himself.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.
Interaction between a mother and child.
Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.
The state wherein the person is well adjusted.
Disorders having the presence of physical symptoms that suggest a general medical condition but that are not fully explained by a another medical condition, by the direct effects of a substance, or by another mental disorder. The symptoms must cause clinically significant distress or impairment in social, occupational, or other areas of functioning. In contrast to FACTITIOUS DISORDERS and MALINGERING, the physical symptoms are not under voluntary control. (APA, DSM-V)
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
Databases devoted to knowledge about specific chemicals.
The function of opposing or restraining the excitation of neurons or their target excitable cells.
Maladaptive reactions to identifiable psychosocial stressors occurring within a short time after onset of the stressor. They are manifested by either impairment in social or occupational functioning or by symptoms (depression, anxiety, etc.) that are in excess of a normal and expected reaction to the stressor.
Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)
The reciprocal interaction of two or more persons.
Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The performance of the basic activities of self care, such as dressing, ambulation, or eating.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The rate dynamics in chemical or physical systems.
A systematic collection of factual data pertaining to health and disease in a human population within a given geographic area.
A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
Method for obtaining information through verbal responses, written or oral, from subjects.
The observable response an animal makes to any situation.
Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A subspecialty of psychiatry concerned with the mental health of the aged.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
Theoretical representations that simulate psychological processes and/or social processes. These include the use of mathematical equations, computers, and other electronic equipment.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Intellectual or mental process whereby an organism obtains knowledge.
Persons who provide care to those who need supervision or assistance in illness or disability. They may provide the care in the home, in a hospital, or in an institution. Although caregivers include trained medical, nursing, and other health personnel, the concept also refers to parents, spouses, or other family members, friends, members of the clergy, teachers, social workers, fellow patients.
Any form of psychotherapy designed to produce therapeutic change within a minimal amount of time, generally not more than 20 sessions.
Organized periodic procedures performed on large groups of people for the purpose of detecting disease.
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
A form of therapy in which two or more patients participate under the guidance of one or more psychotherapists for the purpose of treating emotional disturbances, social maladjustments, and psychotic states.
Disorders related to substance abuse.
A syndrome characterized by depressions that recur annually at the same time each year, usually during the winter months. Other symptoms include anxiety, irritability, decreased energy, increased appetite (carbohydrate cravings), increased duration of sleep, and weight gain. SAD (seasonal affective disorder) can be treated by daily exposure to bright artificial lights (PHOTOTHERAPY), during the season of recurrence.
The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Disorders in which the symptoms are distressing to the individual and recognized by him or her as being unacceptable. Social relationships may be greatly affected but usually remain within acceptable limits. The disturbance is relatively enduring or recurrent without treatment.
Normal, appropriate sorrowful response to an immediate cause. It is self-limiting and gradually subsides within a reasonable time.
Inability to experience pleasure due to impairment or dysfunction of normal psychological and neurobiological mechanisms. It is a symptom of many PSYCHOTIC DISORDERS (e.g., DEPRESSIVE DISORDER, MAJOR; and SCHIZOPHRENIA).
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Learned expectation that one's responses are independent of reward and, hence, do not predict or control the occurrence of rewards. Learned helplessness derives from a history, experimentally induced or naturally occurring, of having received punishment/aversive stimulation regardless of responses made. Such circumstances result in an impaired ability to learn. Used for human or animal populations. (APA, Thesaurus of Psychological Index Terms, 1994)
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The return of a sign, symptom, or disease after a remission.
Mood or emotional responses dissonant with or inappropriate to the behavior and/or stimulus.
Persons who receive ambulatory care at an outpatient department or clinic without room and board being provided.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.
Organized services to provide mental health care.
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Behavior-response patterns that characterize the individual.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.
A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.
Chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.
The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.
Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Conversations with an individual or individuals held in order to obtain information about their background and other personal biographical data, their attitudes and opinions, etc. It includes school admission or job interviews.
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
Computer systems utilized as adjuncts in the treatment of disease.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The physical activity of a human or an animal as a behavioral phenomenon.
Former members of the armed services.
An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.
A learning situation involving more than one alternative from which a selection is made in order to attain a specific goal.
A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
Appraisal of one's own personal qualities or traits.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Cell surface proteins that bind glutamate and act through G-proteins to influence second messenger systems. Several types of metabotropic glutamate receptors have been cloned. They differ in pharmacology, distribution, and mechanisms of action.
The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
The seeking and acceptance by patients of health service.
The human ability to adapt in the face of tragedy, trauma, adversity, hardship, and ongoing significant life stressors.
Statistical interpretation and description of a population with reference to distribution, composition, or structure.
Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.
Sympathectomy using chemicals (e.g., 6-hydroxydopamine or guanethidine) which selectively and reversibly destroy adrenergic nerve endings while leaving cholinergic nerve endings intact.
Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Voluntary cooperation of the patient in following a prescribed regimen.
Personality construct referring to an individual's perception of the locus of events as determined internally by his or her own behavior versus fate, luck, or external forces. (ERIC Thesaurus, 1996).
The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders.
A set of statistical methods for analyzing the correlations among several variables in order to estimate the number of fundamental dimensions that underlie the observed data and to describe and measure those dimensions. It is used frequently in the development of scoring systems for rating scales and questionnaires.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.

Effect of morphine and naloxone on priming-induced audiogenic seizures in BALB/c mice. (1/2575)

1 Morphine (1-200 mg/kg s.c.) reduced the incidence and prolonged the latency of priming-induced audiogenic siezures in a dose-dependent manner. 2 This effect was reversed by naloxone (1 and 2 mg/kg) although naloxone was itself inactive. 3 This priming-induces seizure model may be useful in the study of tolerance and physical dependence.  (+info)

Long-term effects of N-2-chlorethyl-N-ethyl-2-bromobenzylamine hydrochloride on noradrenergic neurones in the rat brain and heart. (2/2575)

1 N-2-Chlorethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP 4) 50 mg/kg intraperitoneally, produced a long-term decrease in the capacity of brain homogenates to accumulate noradrenaline with significant effect 8 months after the injection. It had no effect on the noradrenaline uptake in homogenates from the striatum (dopamine neurones) and on the uptake of 5-hydroxytryptamine (5-HT) in various brain regions. 2 In vitro DSP 4 inhibited the noradrenaline uptake in a cortical homogenate with an IC50 value of 2 muM but was more than ten times less active on the dopamine uptake in a striatal homogenate and the 5-HT uptake in a cortical homogenate. 3 DSP 4 (50 mg/kg i.p.) inhibited the uptake of noradrenaline in the rat heart atrium in vitro but this action was terminated within 2 weeks. 4 DSP 4 (50 mg/kg i.p.) cuased a decrease in the dopamine-beta-hydroxylase (DBH) activity in the rat brain and heart. The onset of this effect was slow; in heart a lag period of 2-4 days was noted. In brain the DBH-activity in cerebral cortex was much more decreased than that in hypothalamus which was only slightly affected. A significant effect was still found 8 months after the injection. The noradrenaline concentration in the brain was greatly decreased for at least two weeks, whereas noradrenaline in heart was only temporarily reduced. 5 The long-term effects of DSP 4 on the noradrenaline accumulation, the DBH activity and noradrenaline concentration in the rat brain were antagonized by desipramine (10 mg/kg i.p.). 6 It is suggested that DSP 4 primarily attacks the membranal noradrenaline uptake sites forming a covalent bond and that the nerve terminals, as a result of this binding, degenerate.  (+info)

Inhibition by amiloride of sodium-dependent fluid reabsorption in the rat isolated caudal epididymis. (3/2575)

The rate of fluid reabsorption was studied in the rat isolated caudal epididymal sac in vitro. 2 Part of the fluid reabsorption was found to be dependent on intraluminal Na+. Amiloride (0.1 mM) completely inhibited this component of fluid reabsorption. 3 The log dose-inhibition curve to amiloride was sigmoid and the IC50 value was found to be 1.6 muM.  (+info)

Further evidence that prostaglandins inhibit the release of noradrenaline from adrenergic nerve terminals by restriction of availability of calcium. (4/2575)

1 Guinea-pig vasa deferentia were continuously superfused after labelling the transmitter stores with [3H](-)-noradrenaline. Release of [3H]-(-)-noradrenaline was induced by transmural nerve stimulation. 2 Prostglandin E2 (14 nM) drastically reduced the release of [3H]-(-)-noradrenaline, while tetraethylammonium (2 mM), rubidium (6 mM), phenoxybenzamine (3 muM) each in the presence or absence of Uptake 1 or 2 blockade, and prolonged pulse duration (from 0.5 to 2.0 ms) all significantly increased the release of [3H]-(-)-noradrenaline per nerve impulse. 3 The inhibitory effect of prostaglandin E2 on evoked release of [3H]-(-)-noradrenaline was significantly reduced by tetraethylammonium, rubidium and prolonged pulse duration, whilst it was actually enhanced by phenoxybenzamine. This indicates that increased release of noradrenaline per nerve impulse does not per se counteract the inhibitory effect of prostaglandin E2. 4 It is concluded that tetraethylammonium, rubidium and prolonged pulse duration counteracted the inhibitory effect of prostaglandin E2 on T3H]-(-)-noradrenaline release by promoting calcium influx during the nerve action potential. The results are consistent with, and add more weight to the view that prostaglandins inhibit the release of noradrenaline by restriction of calcium availability.  (+info)

Possible suppression of host resistance by estrogen therapy for prostatic cancer.(5/2575)


Evaluation of the force-frequency relationship as a descriptor of the inotropic state of canine left ventricular myocardium. (6/2575)

The short-term force-frequency characteristics of canine left ventricular myocardium were examined in both isolated and intact preparations by briefly pertubing the frequency of contraction with early extrasystoles. The maximum rate of rise of isometric tension (Fmas) of the isolated trabeculae carneae was potentiated by the introduction of extrasystoles. The ratio of Fmas of potentiated to control beats (force-frequency ratio) was not altered significantly by a change in muscle length. However, exposure of the trabeculae to isoproterenol (10(-7)M) significantly changed the force-frequency ratio obtained in response to a constant frequency perturbation. Similar experiments were performed on chronically instrumented conscious dogs. Left ventricular minor axis diameter was measured with implanted pulse-transit ultrasonic dimension transducers, and intracavitary pressure was measured with a high fidelity micromanometer. Atrial pacing was performed so that the end-diastolic diameters of the beats preceding and following the extrasystole could be made identical. Large increases in the maximum rate of rise of pressure (Pmas) were seen in the contraction after the extrasystole. The ratio of Pmax of the potentiated beat to that of the control beat was not changed by a 9% increase in the end-diastolic diameter, produced by saline infusion. Conversely, isoproterenol significantly altered this relationship in the same manner as in the isolated muscle. Thus, either in vitro or in situ, left ventricular myocardium exhibits large functional changes in response to brief perturbations in rate. The isoproterenol and length data indicate that the force-frequency ratio reflects frequency-dependent changes in the inotropic state, independent of changes in length.  (+info)

Effect of paracetamol (acetaminophen) on gastric ionic fluxes and potential difference in man. (7/2575)

Paracetamol has replaced aspirin as the analgesic of choice in many situations. The major reason is the damaging effect of aspirin on gastric mucosa. Alterations in gastric ionic fluxes and potential difference provide measures of aspirin-induced structural damage. We studied the effect of large doses of paracetamol (acetaminophen 2-0 g) on gastric ionic fluxes in man. In addition, the effect of 2-0 g paracetamol on gastric potential difference was compared with that of 600 mg aspirin. In contrast with salicylates, paracetamol caused no significant alteration in movement of H+ and Na+ ions over control periods. Aspirin causes a significant fall in transmucosal potential difference (PD) across gastric mucosa of 15 mv, while paracetamol cuased no significant change. Paracetamol in a dose four times that recommended does not alter gastric ionic fluxes or potential difference. These studies support choice of paracetamol as analgesic over aspirin where damage to gastric mucosa may be critical.  (+info)

Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin. (8/2575)

Motor nerve conduction velocity was measured after dosing guinea-pigs with 200-400 mumol/kg diphenylhydantoin (DPH) daily for three to four days. Conduction velocity fell by a mean value of 13% in animals that achieved plasma DPH levels over 200 mumol/l. There was no change in velocity with DPH levels below this value.  (+info)

Sugar variability imposes a direct negative influence on the consistent operation and output of the bakery. Management/reduction of variability will lead to increased operational efficiency, product quality, and economic management. Through the discussion of several case studies, three key variability opportunities will be illustrated. Naturally occurring or inherent variability, behavioral variability, and process variability are three of the most impactful areas that can significantly affect the consistency of operations. Understanding how to determine what to measure and how to apply those key learnings to your bakery operations is key when focusing limited resources on consistency issues. Gaining knowledge through learning and teaching to identify variability contributing attributes and determining the appropriate variability reducing methods will facilitate improved focused and coordinated troubleshooting and problem-solving efforts.. Attendees will learn: ...
Im going through a rough emotional time right now and my doc prescribed 20 mg of Celexa. Im to take 1/2 pill per day. I have never been on anti depressants before...
A negative chronotropic effect is an action to the heart that causes the organ to beat slower than before. This is often achieved by increasing vagal or parasympathetic stimulation or decreasing...
Depressant, Definition of Depressant: (chiefly of a drug) reducing functional or nervous activity. A depressant drug. Substance that reduces or obstructs a normal bodily activity, function, or an instinctive desire s…
The cardiovascular system plays a key role in sepsis, and septic myocardial depression is a common finding associated with increased morbidity and mortality. Myocardial depression during sepsis is not clearly defined, but it can perhaps be best descr
Competitively inhibit the action of adrenaline and noradrenaline on β1 receptors (the predominant β receptors in the heart), resulting in suppression of the sympathetic nervous system with negative inotropy, chronotropy, dromotropy and lusiotropy ...
We have emailed you at with instructions on how to set up a new password. If you do not receive an email in the next 24 hours, or if you misplace your new password, please contact:. ASA members: ...
Inotropy falls in acidosis due to a direct myocardial depressant effect. May be offset by increased SNS tone in low-grade acidosis. Alkalosis may increase inotropy by increasing responsiveness to circulating catecholamines ...
Numerous studies have shown a beneficial effect of combination therapy with beta-blockers and calcium antagonists in patients with anginal syndrome and/or hypertension. However, because both agents exert a negative chronotropic effect, their combined
The commission may except by rule any compound, mixture, or preparation containing any stimulant or depressant substance listed in subsection (a)(1) and (2) of this section from the application of all or any part of this chapter if the compound, mixture, or preparation contains one or more active medicinal ingredients not having a stimulant or depressant effect on the central nervous system, and if the admixtures are in combinations, quantity, proportion, or concentration that vitiate the potential for abuse of the substances having a stimulant or depressant effect on the central nervous system ...
Anti depressants Join our community. Leading products. Trusted For All specialize in supplying special featured medicines, developed to improve your life and makes better your health. We offer 60 Products in our store. AntidepressantAntidepressant.
Connexin. 43 (Cx43) is the predominant gap junction (GJ) protein in the mammalian ventricular myocardium. The precise spatial order of Cx43 GJ channels in the heart is thought vital for maintaining cardiac synchrony. Disruption or remodelng of this order is a hallmark of arrhythmic disease and has been reported in ischemic and diabetic hearts. Protein-protein interactions and modifications of the Carboxyl-terminus (CT) of CX43 are major determinants of GJ function, size, distribution and organization during normal development and disease processes. The extreme CT domain of CS43 interacts directly with the second PDZ domain of the MAGUK protein Zonula Occludens 1 (ZO-1). It has been reported that this interaction regulates phosphorylation of Cx43 and directs Cx43 GJ localization at the intercalated disk. Additionally, levels of this interaction are increased in the ischemic and dilated heart suggesting a role of Cx43 ZO-1 association in disease. Recent work from the Gourdie laboratory has ...
23 October 2020... Monica Keena news, gossip, photos of Monica Keena, biography, Monica Keena boyfriend list 2016. Relationship history. Monica Keena relationship list. Monica Keena dating history, 2020, 2019, list of Monica Keena relationships.
The present study shows a negative inotropic effect of pantoprazole in isolated myocardium. This was dose dependent, induced nearly complete inhibition of twitch force at very high doses, and was partially reversible. Negative inotropy of pantoprazole was present in myocardium from different species (human and rabbit) and in myocardium from different origins (atrial and ventricular), and it was found in different myocardial preparations (multicellular and single cells). The EC50 for contractile force depression was 30.6±1.8 μg/mL in nonfailing human atrial and 17.3±1.3 μg/mL in failing human ventricular myocardium, respectively. Moreover, similar results could be obtained with esomeprazole, which is suggestive of a class effect of PPIs. Furthermore, we could reveal 2 underlying mechanisms for the pantoprazole-dependent inhibition of contractile force: (1) reduction in the amplitude of Ca2+ transients as a consequence of impaired SR Ca2+ uptake and reduced Ca2+ influx via ICa,L and (2) ...
In the present study we showed that neostigmine possessed dual chronotropic effects on the spontaneously beating right atrium in the guinea pig. Neostigmine decreased the beating rate at lower concentrations in a concentration-dependent manner. Subsequent application of higher concentrations of the agent returned the beating rate to the predrug control level. Both responses were abolished by atropine. In contrast, edrophonium did not affect the basal beating rate. Although edrophonium lacked the direct negative chronotropic effect, it potentiated the negative chronotropic effect of endogenous ACh released from the cholinergic nerve terminals by the electrical FS, which indicated that edrophonium could evoke bradycardia only by inhibiting the hydrolysis of ACh molecules released from the cholinergic nerve terminals. The bradycardiac effect of the FS was also potentiated by neostigmine at a concentration lower than concentrations that decreased the beating rate directly. TTX did not inhibit the ...
Myocardial depression in septic patients is well recognized yet still poorly understood. The prognostic significance in terms of overall mortality when it is identified, remains in dispute. Parameters of left ventricular function measured by tissue Doppler imaging may assist in resolving whether dysfunction identified early in the course of sepsis is a good prognostic sign.
Predicted changes in the intensity and frequency of climate extremes urge a better mechanistic understanding of the stress response of microbially-mediated carbon and nutrient cycling processes. This study is the first comprehensive study of the resistance and resilience of microbial C, N, and P cycling processes in decomposing plant litter to severe temperature disturbances. Disturbances led temporarily to a more rapid cycling of C and N but caused a down-regulation of P cycling. In contrast to the fast recovery of C and N processes, we found a slow recovery of P mineralization rates. The functional and structural responses to the two distinct temperature disturbances were markedly similar, suggesting that direct negative physical effects and costs associated with the stress response were comparable. This study provides novel insights into the mechanisms of microbial functional stress responses and illustrates the need for a closer integration of microbial C-N-P interactions into climate ...
© [[IS VALIUM A CNS DEPRESSANT]] Fast Shipping, Friendly Support, High-Quality Customer Service , Is Valium A Cns Depressant FDA Approved Drugs, Fast Delivery.
Are you or someone you know addicted to sedatives? Learn about the addiction symptoms of depressants and what you can do to help.
1. Incubation of intact epididymal adipose tissue from fed rats at 37° in an albumin solution at pH7·4 in vitro results in rapid loss of clearing-factor lipase activity until a low activity, stable to prolonged incubation, is attained. The clearing-factor lipase activity of intact tissue from starved rats, which is initially much less than that of tissue from fed rats, is mainly stable to incubation at 37°. 2. Much of the clearing-factor lipase activity of intact epididymal adipose tissue from fed rats is inactivated by collagenase. The enzyme activity of intact tissue from starved rats is not inactivated by collagenase. 3. The clearing-factor lipase activity of fat cells isolated from the epididymal adipose tissue of fed rats is stable to prolonged incubation at 37°. It represents only a small proportion of the total activity of the intact tissue. In starved rats, the isolated fat cells contain a much higher proportion of the activity of the intact tissue. Their activity is also stable at ...
TY - JOUR. T1 - Depressant effects of phenoxybenzamine on potassium contracture in cat ventricular muscle. AU - Wiggins, Jay R.. AU - Gelband, Henry. AU - Bassett, Arthur L.. PY - 1979/10/26. Y1 - 1979/10/26. N2 - Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not depressed by phentolamine nor augmented by phenylephrine. Thus, the depressant action of phenoxybenzamine is not mediated by its effects on cardiac adrenergic receptors.. AB - Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not ...
Whole-cell voltage clamp measurements were applied to isolated myocytes to examine the effect of sevoflurane on separated calcium and potassium currents, which play key roles in myocardial excitation-contraction coupling. According to an established protocol, guinea pig ventricular myocytes were isolated enzymatically. [24] English Shorthair guinea pigs (weighing approximately 300 g) were anesthetized with 50 mg/kg sodium pentobarbital according to the guidelines of the University of Virginia Animal Research Committee. The heart was quickly excised and perfused (30 mmHg perfusion pressure) using a Langendorff perfusion system. All solutions were passed through a 0.2-micro meter filter, equilibrated with 95% O2and 5% CO2to pH 7.4 and maintained at 37 degrees C. The heart was perfused for 5 min with solution identical to the modified Tyrode solution, except for the omission of calcium and addition of 5 mM pyruvic acid. The calcium-free buffer was then supplemented with 25 micro Meter CaCl2, 0.5 ...
Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
BioAssay record AID 467401 submitted by ChEMBL: Negative chronotropic activity in guinea pig right atrium assessed as decrease in atrial rate at 50 uM relative to control.
Anti depressant and Drug Symbollism Art piece - MORE ART, LESS CRAFT - This is one of my works in progress. I made all of the pills inside. This is to signify how humans are relying on drugs and medication to cure t
TY - JOUR. T1 - Myocardial depression in sepsis. AU - Raffa, James. AU - Trunkey, Donald. PY - 1978. Y1 - 1978. N2 - Myocardial failure is uniformly fatal when associated with post-traumatic sepsis and multisystem failure. Controversy exists as to whether endotoxin has a direct effect on the myocardium. A nonanoxic isolated arterially perfused rabbit interventicular septum was used in this study to evaluate the effects of endotoxin, live E. coli, and endotoxin/septic shock plasma on myocardial function and ultrastructure. Purified E. coli endotoxin and live E. coli bacteria did not have a significant direct effect on rabbit cardiac muscle function or ultrastructure. Perfusion of the rabbit septum with plasma from rabbits exsanguinated following a 2-hour septic or endotoxin shock insult, however, caused significant (p ,0.02) myocardial depression when compared with control septa perfused with normal rabbit plasma. Septa perfused with shock plasma demonstrated ultrastructural alterations of ...
Bupivacaine-induced myocardial depression and pulmonary edema: a case report.: Central nervous system and cardiovascular toxicity are well-known side effects of
We are manufacturer of ZW Self-priming sewage pump, ZW Self-priming sewage pump China, if you want to buy China ZW Self-priming sewage pump, please contact us.
BioAssay record AID 213359 submitted by ChEMBL: Rate constant of acylation on trypsin was determined at 10 percent and at 95 minutes for maximum inhibition and no enzyme activity was recovered over the 2 h-time.
Does anyone have bouts of extreme depression in the 2 weeks leading up to their periods? I am 43, and since having ds at 41, have been suffering fro
The chronotropic responses to repetitive bursts of vagal stimulation were determined in open-chest, anesthetized dogs. Either 5 or 10 electrical pulses were included in each stimulus burst, and the interpulse interval (deltat) was varied over the range of 5 to 150 msec. As the frequency of the stimulus bursts was progressively changed, the sinoatrial (SA) nodal pacemaker cells became synchronized with the repetitive bursts of stimuli over a certain range of burst frequencies. The magnitude of this frequency range varied with deltat. For 5 and 10 pulses/burst, the values of deltat that produced the greatest magnitude of this frequency range were 30.2 and 24.3 msec, respectively. Also, over the range of values of deltat from 5 to 50 msec, the magnitude of the negative chronotropic effect of the vagal stimulus burst varied directly with deltat. It is likely that, as the interpulse interval is increased within the range of values, either more acetylcholine is released from the vagal nerve endings ...
PARIS, FRANCE, and HENNIGSDORF/BERLIN, GERMANY / ACCESSWIRE / August 31, 2019 / Diagnostics company SphingoTec GmbH (sphingotec, Hennigsdorf near Berlin,
1. Diminishing functional tone or activity. 2. An agent that reduces nervous or functional activity, such as a sedative or anesthetic. [L. de primo, pp. pressus, to press down] * * * de·pres·sant ənt
Leo, J., & Lacasse, J. (2007, 10 October). The Media and the Chemical Imbalance Theory of Depression. Retrieved 1 December 2014 ... Neurotransmitters, also known as chemical messengers, are endogenous chemicals that enable neurotransmission. They transmit ... An antagonist is a chemical that acts within the body to reduce the physiological activity of another chemical substance (as an ... of serotonin seemed to help some people diagnosed with depression, it was theorized that people with depression might have ...
Freezing-point depression[edit]. Main articles: Freezing-point depression and Supercooling. The freezing point of a solvent is ... The chemical element with the highest melting point is tungsten, at 3,414 °C (6,177 °F; 3,687 K);[4] this property makes ... Brown, R. J. C. & R. F. C. (2000). "Melting Point and Molecular Symmetry". Journal of Chemical Education. 77 (6): 724. Bibcode: ... List of common chemicals Chemical[I] Density (. .mw-parser-output .nobold{font-weight:normal}. .mw-parser-output .sfrac{white- ...
Causes of acute fatigue include depression; chemical causes, such as dehydration, poisoning, low blood sugar, or mineral or ... Depression and other psychological conditions can produce fatigue, so people who report fatigue are routinely screened for ... Substance use disorders including alcohol use disorder Depression and other mental disorders that feature depressed mood ...
McCoy, Michael (12 March 2012). "Happy Results for a Depression Drug". Chemical & Engineering News Archive. 90 (11): 20-22. doi ... DOV 216,303 was originally in development for depression; however as the patented composition of matter claim has expired, ... Bicifadine, a triple-uptake inhibitor for pain, licensed from Wyeth in 1998, Triple-uptake inhibitors for depression and ... 2015 Chemical and Engineering News. 12 August 2004 Merck and DOV Pharmaceutical In Drug Pact Dov 8 December 2006 DOV ...
... he developed a system of chemical notation in which the elements composing any particular chemical compound were given simple ... He also had episodes of depression. In 1818, Berzelius had a nervous breakdown, said to be due to the stress of his work. The ... At this time the concept of chemical structure had not yet been developed so that he considered only the numbers of atoms of ... He developed improved methods of chemical analysis, which were required to develop the basic data in support of his work on ...
Clumsiness, depression and irritability are noted. What begins as a slurring and slowing of speech eventually leads to ... Movement is normally controlled by dopamine; a chemical that carries signals between the nerves in the brain. When cells that ... As the disease progresses, non-motor symptoms may also appear, such as depression, difficulty swallowing, sexual problems or ... "a chemical imbalance". Iris Murdoch, the British writer and philosopher, developed Alzheimer's disease. She was portrayed by ...
Giovanna Calvino talks about depression and approval; Anna Funder talks about chemical identity. Through the words of these ...
Initially, Banks was ashamed to disclose her career and lied about her job; this contributed to her suffering from depression. ... Banks started webcamming in 2010 at the age of 19 while studying chemical engineering. ...
Chemical & Engineering News Special Issue published June 19, 2006. Vol 84(25):56-78 Link to article Archived Davies K.: Putting ... Use of desoxypeganine for treating clinical depression. Published July 3, 2002. Link to PCT document COID journal website " ... and depression. Hermann Mucke is Patent Editor at the Thomson Reuters journal, Current Opinion in Investigational Drugs and an ...
Evan was diagnosed with depression at age 5, and he was later diagnosed with bipolar depression. Despite the treatment and ... Evan was prescribed a dosage of lithium to help with the chemical imbalance in his brain. When Evan was stable enough to leave ... The film is based on the life of Evan Perry, who experienced bipolar depression from a young age. The documentary was filmed ... None of his friends could tell that Evan had bipolar depression, the only time they noticed something off was closer to the ...
For example, depression, allergy, thyroid disorders, orthostatic syndromes, lupus, hypercalcemia, and anxiety need to be ... Chemical triggers[edit]. Many chemicals have been reported to trigger MCS symptoms.[10] Substances with strong scents are the ... and organic solvents as the mechanism of chemical sensitivity in multiple chemical sensitivity". FASEB J. 16 (11): 1407-17. doi ... recurring disease caused by a person's inability to tolerate an environmental chemical or class of foreign chemicals".[9] A ...
Her death has been attributed to depression over her father's death.[19] Her suicide was also related to a family history of ... Clover had frequently used this poisonous chemical in the processing of her photographs. Adams carried his wife to a sofa, then ... Already, in 1894, conscious of the consequences of the economic depression for the world of Western whites, Henry Adams had ... mental depression and suicide, a sense of frustration and lack of fulfillment as a cultured person and as a woman, and a ...
All tracks are written by My Chemical Romance. The song is about depression and contemplating suicide. The lyrics, "Now the red ... 1] "My Chemical Romance - I Brought You My Bullets, You Brought Me Your Love - Alternative Press". Alternative Press. Retrieved ... "Headfirst for Halos" is the sixth track and third single from My Chemical Romance's debut album, I Brought You My Bullets, You ...
My Chemical Romance broke into the mainstream with their 2004 album Three Cheers for Sweet Revenge. My Chemical Romance is ... Other stereotypes include depression, self-harm and suicide. Some people explained the difference between emos and goths by ... "My Chemical Romance , Biography & History". AllMusic. Retrieved August 12, 2018. "American album certifications - My Chemical ... My Chemical Romance reacted online to the suicide of Hannah Bond: "We have recently learned of the suicide and tragic loss of ...
J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp ... Etoperidone was used or was intended for use as an antidepressant in the treatment of depression. Etoperidone is as an ... It is a phenylpiperazine related to trazodone and nefazodone in chemical structure and is a serotonin antagonist and reuptake ... Silvestrini, B (1986). "Trazodone and the mental pain hypothesis of depression". Neuropsychobiology. 15 Suppl 1: 2-9. doi: ...
Individuals suffering with depression also showed a specific deficit in retrieving information meaningfully organized in their ... Fuld, P.A., Katzman, R., Davies, P., & Terry, R.D. (2004). Intrusions as a sign of Alzheimer dementia chemical and pathological ... Ilsley, J.E., Moffoot, A.P.R., & O'Carroll, R.E. (1995). An analysis of memory dysfunction in major depression. Journal of ... Memory errors can occur in patients with depression or with depressive symptoms. Patients with depressive symptoms have a ...
DOV 216,303 was originally in development for depression; however as the patented composition of matter claim has expired, ... Update:[clarification needed] Bicifadine McCoy M (August 12, 2004). "Merck and DOV Pharmaceutical In Drug Pact". Chemical & ...
The Great Depression dried up the tourist trade. The population of Bromide fell to 352 in 1930, 258 in 1950, and to 180 in 1980 ... Manganese (chemical symbol: Mn) ore was discovered in the vicinity of Bromide in 1890. A report published by the U.S. ... However, the Great Depression put an end to the concept. The nearby Wapanucka Academy site is listed in the National Register ...
... is made by chemical synthesis and acts on opioid receptors. Methadone was developed in Germany around 1937 to 1939 by ... Serious risks include opioid abuse and respiratory depression. Abnormal heart rhythms may also occur due to a prolonged QT ... Methadone has the following US FDA black box warning: Risk of addiction and abuse Potentially fatal respiratory depression ... is far too long to represent a true chemical bond. However, it does represent the initial trajectory of attack of an amine on a ...
Depression is caused by a number of factors, from chemical imbalances to psychological make-up to environmental influences. ... Depression is one of the leading causes of suicide. Another problem with teens and social media is cyberbullying. When teens ... Depression and drug use among LGB people have both been shown to increase significantly after new laws that discriminate ... Depression can play a massive role in teenage suicide. Some contributing factors include: Eating disorders Drug abuse Sexual ...
He suffered from severe depression and became absentminded. He turned every conversation to the topic of childbed fever. After ... since the poison could be neither chemical nor physical in operation, it must be biological. It has been contended that ...
Leo, J., & Lacasse, J. (10 October 2007). The Media and the Chemical Imbalance Theory of Depression. Retrieved 1 December 2014 ... An antagonist is a chemical that acts within the body to reduce the physiological activity of another chemical substance (as an ... of serotonin seemed to help some people diagnosed with depression, it was theorized that people with depression might have ... Neurotransmitters are chemical messengers that transmit a signal from a neuron across the synapse to a target cell, which can ...
On chemical imbalances, antidepressants, and the diagnosis of depression. Ethical Human Psychology and Psychiatry, 11(3), 199. ... Sequenced Treatment Alternatives to Relieve Depression (STAR*D) was a collaborative study on the treatment of depression, ... Instead, depression was assessed using an ex-nihilo study scale (QIDS-SR), which was used for both medical decision-making and ... The STAR*D researchers state that their data "suggest that a patient with persistent depression can get well after trying ...
Pungent-tasting chemical compound 1-(2,4,6-trimethoxyphenyl)-but-2(E)-en-1-one was isolated from ether extract of Hymenophyton ... Adjacent cells connected through small perforations within the depression. Apigenin 6,8-di-C-glycosides have been detected as ... This chemical compound is responsible for the pungent taste of H. flabellatum upon chewing. Hymenophyton flabellatum is act as ... Chemical & Pharmaceutical Bulletin. 49 (10): 1380-1381. doi:10.1248/cpb.49.1380. ISSN 0009-2363. "Bryophyte Ecology Volume 2 ...
... few academic positions were available due to the Great Depression. Prelog was in charge of the production of rare chemicals ... American Chemical Society & Chemical Heritage Foundation. ISBN 0-8412-2459-5. .. *^ Dunitz, J. D. (1998). "Obituary: Vladimir ... Purely chemical methods had become outdated and had lost some of their intellectual appeal. Recognizing the growing importance ... Following his father's wishes, he moved to Prague, where he received his diploma in chemical engineering from the Czech ...
... was originally developed by Bayer Healthcare AG (Wuppertal, Germany) as an oral treatment for depression.[11] However ... It is similar in chemical and physical properties to the ligands quetiapine, PAT5A, and pioglitazone.[14] ... Its current investigation as an antagonist for respiratory depression caused by morphine has shown there to be no serious ... Repinotan has presently been found to be effective at stopping respiratory depression caused by morphine. In addition, it ...
Further ahead the train has a tight curve near a chemical plant. Barstow agrees that they must crash it, thus condemning the ... Emotionally broken, all three slump into depression. Suddenly Ranken's accomplice is lowered from a helicopter to the lead ... three people, rather than risk a chemical explosion. Warden Ranken forces Barstow to help him reach the train by helicopter. ...
When he was 11, his father was injured in a workplace chemical explosion at the Rust-Oleum plant near Williamsport, Maryland.[ ... "Lil Skies on 'Shelby', Dealing w/ Depression, XXXTentacion + More! - YouTube". Retrieved 2020-12-16. "Lil ... of Waynesboro emerges stronger after suffering third-degree burns in Rust-Oleum chemical…". The Record Herald. Retrieved ... Skies on 'Shelby', Dealing w/ Depression, XXXTentacion + More! - YouTube". Retrieved 2020-12-16. Bonura, ...
Indalpine Pipequaline J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and ... George I. Papakostas; Maurizio Fava (2010). Pharmacotherapy for Depression and Treatment-resistant Depression. World Scientific ... 1-. ISBN 978-1-4757-2085-3. Faravelli C, Albanesi G, Sessarego A (1988). "Viqualine in resistant depression: a double-blind, ... Faravelli, Carlo; Albanesi, Giorgio; Sessarego, Antonella (1988). "Viqualine in Resistant Depression: A Double-Blind, Placebo- ...
Depression, chronic stress, bipolar disorder, etc. are considered mood disorders. It has been suggested that such disorders ... result from chemical imbalances in the brain's neurotransmitters, however some research challenges this hypothesis. The idea of ... Delgado, P (2000). "Depression: the case for a monoamine deficiency". Journal of Clinical Psychiatry. 61: 7-11. PMID 10775018. ... This effect is most marked in persons with an eveningness type (so called night-owls) and people suffering from depression. For ...
Stassinos, Elizabeth (1997). "Marriage as Mystery Writ Symbiotically: The Benedicts' Unpublished "Chemical Detective Story" of ... and she suffered from depression and severe loneliness.[7] However, through reading authors like Walt Whitman and Jefferies ...
These include depression, food allergies, ingestion of certain chemicals, bulimia, anorexia nervosa, pituitary gland ...
"Biology-based" as coined by NCCIH may refer to chemicals from a nonbiological source, such as use of the poison lead in ... And lastly there's the cynicism and disappointment and depression that some patients get from going on from one alternative ... changing social attitudes about not using chemicals and challenging the establishment and authority of any kind, sensitivity to ... and that can create depression and make the eventual treatment of the patient with anything effective difficult, because you ...
Electrical or chemical stimulation of the rat hippocampus causes strengthening of synaptic signals, a process known as long- ... people suffering from temporal lobe epilepsy report symptoms of negative effects such as anxiety and depression that might ... and some medically unexplained syndromes such as fibromyalgia and multiple chemical sensitivity. Sensitization may also ...
The sugars are then stored as starch, further processed by chemical synthesis into more complex organic molecules such as ... Surface of leaf raised in a series of domes between the veins on the upper surface, and therefore also with marked depressions ... Marked with dots; dotted with depressions or with translucent glands or colored dots.. Rugose. Deeply wrinkled; with veins ... Leaves also function to store chemical energy and water (especially in succulents) and may become specialized organs serving ...
... and chemical pathologists.[7] ... depression. *hip and shoulder weakness. *swelling of feet/legs ...
During the depression phase, the inspiratory burst changes from an augmenting bell-shaped burst to a decrementing burst, a ... Since many of these neurons express GABA, glutamate, serotonin and adenosine receptors, chemicals custom tailored to bind at ... and chemical signals, such as adenosine, GABA, and glycine. The pre-Bötzinger complex produces two types of breathing rhythms ... the respiratory network responds by transitioning into an augmentation followed by a depression phase, controlled in the pre- ...
Indium electroplated into the depressions formed the collector and emitter.[30][31] ... "Nanofluidic transistor, the basis of future chemical processors". Archived from the original on July 2, 2012 ... These were made by etching depressions into an N-type germanium base from both sides with jets of Indium(III) sulfate until it ...
... or more are considered to be deep chemical peels.[32] Medium-strength and deep-strength chemical peels are more effective for ... There are concerns that isotretinoin is linked to adverse effects, like depression, suicidality, and anemia. There is no clear ... Chemical peels can be used to reduce the appearance of acne scars.[32] Mild peels include those using glycolic acid, lactic ... Rasmusson GH (1986). Chemical Control of Androgen Action. Annual Reports in Medicinal Chemistry. 21. pp. 179-188. doi:10.1016/ ...
"Blood chemicals link' to eczema". Health. BBC NEWS. 2007-08-26. Retrieved 2008-11-01.. ... major depression and related disorders;[49][50][51] fibromyalgia;[52] rheumatological;[53] and infections such as HIV/AIDS and ... SP initiates expression of almost all known immunological chemical messengers (cytokines).[19][20][21] Also, most of the ... To be populated re IL6, immunology of depression/anxiety, psycho-immune interface. ...
Mineralogical and chemical analysis of these coprolites indicates that if the referral to Herrerasaurus was correct, this ... and a broad supratemporal depression (noted by Sereno and Novas, 1993);[17] the basal tuber and the occipital condyle are ... and the humeral entepicondyle is ridge-like with anterior and posterior depressions; and the posterior border of the ilial ... the subquadrate ventral squamosal process has a lateral depression, and the quadratojugal bone overlaps the posterodorsal ...
1979: Jenny Patrick became the first African-American woman in the United States to earn a Ph.D. in chemical engineering, which ... In addition, the 1930s marked great economic hardship in the United States with the start of the Great Depression. At this ... As the number of college graduates increased, those who were displaced during the Great Depression had to compete with a ... but home economics also experienced a great surge in popularity during the Depression.[32] Home economics brought a scientific ...
In preadolescent male rats, neonatal rats treated with flutamide developed more depression-like symptoms compared to control ... Androsterone is a chemical byproduct created during the breakdown of androgens, or derived from progesterone, that also exerts ... Androgen regulation decreases the likelihood of depression in males. ... of androgens has a positive effect on preadolescent hippocampal neurogenesis that may be linked with lower depression-like ...
Journal of Chemical Education. American Chemical Society. 80 (8): 952-961. Bibcode:2003JChEd..80..952J. doi:10.1021/ed080p952. ... manic-depression) in daily doses of about 0.5 to 2 grams, although there are side-effects.[219] Excessive ingestion of lithium ... Physical and chemicalEdit. The physical and chemical properties of the alkali metals can be readily explained by their having ... Connelly, Neil G.; Geiger, William E. (1996). "Chemical Redox Agents for Organometallic Chemistry". Chemical Reviews. 96 (2): ...
The chemical structures of CX-717 and CX-1739 have not yet been revealed by Cortex Pharmaceuticals, but are presumably similar ... 1] Ren J, Ding X, Funk GD, Greer JJ (June 2009). "Ampakine CX717 protects against fentanyl-induced respiratory depression and ... "continue its plans to develop CX717 for the acute treatment of respiratory depression (RD) and continue its study of CX717 in ... "Selective antagonism of opioid-induced ventilatory depression by an ampakine molecule in humans without loss of opioid ...
Necrotic cells send the wrong chemical signals which prevent phagocytes from disposing of the dead cells, leading to a buildup ... and even psychological symptoms such as depression and anxiety.[16] ...
"ACS Chemical Biology. 11 (9): 2499-2505. doi:10.1021/acschembio.6b00182. ISSN 1554-8929. PMC 5027137 .. ... depression, fatigue, anemia, and decreased semen/ejaculate volume in males.[74] Conversely, the side effects of selective AR ... See also: Paraphilia § Antiandrogens, and Chemical castration § Treatment for sex offenders. Androgens increase sex drive,[38] ... based on chemical structure: steroidal and nonsteroidal.[57][58][65] Steroidal AR antagonists are structurally related to ...
Depression[edit]. Main article: Major depressive disorder. Using data from the ECA study, Eaton, Anthony, Mandel, and Garrison ... International Chemical Safety Card. *National Day of Mourning (Canadian observance). *Process safety management ... 2017). Job strain as a risk factor for clinical depression: Systematic review and meta-analysis with additional individual ... depression or coronary heart disease: A prospective cohort study of 69,842 employees. Occupational and Environmental Medicine, ...
This melon consists of fat, and the skull of any such creature containing a melon will have a large depression. The melon size ... High levels of organic chemicals accumulate in these animals since they are high in the food chain. They have large reserves of ...
Phantosmia Hyposmia Multiple chemical sensitivity, a condition that some believe is caused by a very acute sense of smell ... ISBN 0-684-85394-9. Henkin, RI (1990-12-05). "Hyperosmia and depression following exposure to toxic vapors". JAMA: the Journal ...
Depression[edit]. GABA ergic hypothesis for depression has been proposed. This hypothesis places the GABA system in a central ... Fig 3. Binding sites of different therapeutic chemical groups on a GABAA receptor ... The mice also had increased corticosterone concentration which is a symptom in major depression in humans. The y2 subunit is ... Other studies with α2 knockout mice have displayed increased anxiety and depression-like symptoms in conflict based feeding ...
McKewan, Jaclyn (2009). "Evolution, Chemical". In H. James Birx". Predeterminism. Encyclopedia of Time: Science, Philosophy, ... Overall brain health, substance dependence, depression, and various personality disorders clearly influence mental activity, ...
Chemical compound * sw:Chemical compound. Chemical element * sw:Chemical element. Chemistry * sw:Chemistry. Chess * sw:Chess. ... Great Depression * sw:Great Depression. Great Lakes * sw:Great Lakes. Great Wall of China * sw:Great Wall of China. Greek * sw: ...
When khat leaves dry, the more potent chemical, cathinone, decomposes within 48 hours, leaving behind the milder chemical, ... depression[7]:10. *infrequent hallucinations[2][7]:10. *impaired inhibition (similar to alcohol)[7]:10[25] ... These chemicals belong to the PPA (phenylpropanolamine) family, a subset of the phenethylamines related to amphetamines and the ... Receptors for serotonin show a high affinity for cathinone, suggesting this chemical is responsible for feelings of euphoria ...
Psychotic depression, unipolar endogenous depression, melancholic depression, retarded depression, agitated depression and ... Chemical and physical data. Formula. C13H17ClN2O2. ... Bipolar depression. While not generally recommended as a ... neurotic depression all respond to moclobemide.[22] As does atypical depression.[23] Unipolar endogenous depression is reported ... Results of new subscales of the Hamilton Depression Rating Scale". Clin Neuropharmacol. 16 Suppl 2: S55-62. PMID 8313398.. ...
From 1857 onwards, Nightingale was intermittently bedridden and suffered from depression. A recent biography cites brucellosis ...
In order to offset the numerous chemical and metal based poisoning that humans were inadvertently exposing the species to, a ... some may be only a scooped shallow depression of soil, or pile of heather or juniper stems with stipes of dried Laminaria, but ... Beyond the threat of chemical poisonings, a new threat from wind turbines is emerging with significant mortality (considerably ... Bringing together raptor collections in Europe for contaminant research and monitoring in relation to chemicals regulations. ...
Research into the causes of this state is relatively limited, but some studies suggest a link with depression, cancer and ...
"Nature Chemical Biology. 7 (10): 740-7. doi:10.1038/nchembio.642. PMC 3177959. PMID 21873996.. ... both were withdrawn owing to a high incidence of depression and anxiety, which are believed to relate to the inhibition of the ... In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.[1] When ... a receptor is a protein-molecule that recognizes and responds to endogenous chemical signals, e.g. an acetylcholine receptor ...
Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State ... Pilhatsch MK, Burghardt R, Wandinger KP, Bauer M, Adli M: Augmentation with atomoxetine in treatment-resistant depression with ...
Antidepressants targeting the chemical imbalance theory remain the go-to treatment for this condition nonetheless, doing those ... The widely held belief that depression is due to low levels of serotonin or other chemicals in your brain is only a theory, one ... The widely held belief that depression is due to low levels of serotonin or other chemicals in your brain is only a theory - ... Many people believe depression is caused by a chemical imbalance in the brain; this chemical imbalance theory has been widely ...
TO SEE IF THEY REALLY DO HAVE A CHEMICAL IMBALANCE THAT REQUIRES MEDICATION. ... chemical imbalance testing tracy I WOULD LIKE TO KNOW THE NAME OF THE TEST THAT CAN BE DONE ON KIDS WITH ADHD? TO SEE IF THEY ... i need to know if i have a chemical imbalance or if i have split personalitys because everyone i know tells me i have one or ... Can depression and anxiety cause heart disease? Get the facts in this Missouri Medicine report. ...
If depression could be cured by improving an imbalance, there would be a much higher success rate for the current ... The onset of depression is far more complex than a chemical imbalance. ... The onset of depression is far more complex than a chemical imbalance. If depression could be cured by improving an imbalance, ... and the functioning of circuits in our brains all have an impact on depression. There are millions of chemical reactions that ...
Learn more information about depression, treatment options, and prevention. ... Learn more about the chemical connection to depression from Discovery Health. ... Brain Chemicals. Depression is a disorder of the brain. Researchers in the area of mood disorders believe that chemicals called ... In the brain, the chemicals are neurotransmitters. In the body, the chemicals are hormones. These chemicals can affect you in ...
... depression, anxiety - Answer: Im sorry buzzlebee, but I am in total agreeance with you, so I think that ... ... say psychotic depression, manic depression,(bipolar or unipolar, or bipolar1 or bipolar2) major depression, primary depression ... How can cognitive behavior therapy help depression if its a chemical imblance?. Asked. 16 Apr 2012 by Anonymous. Updated. 23 ... Since anxiety is at the root of depression and the stress to the body becomes cortisol overload, the chemicals in the brain end ...
Canada Although the etiology of depression remains to be elucidated ... - Selection from Chemical Biology: Approaches to Drug ... Depression Glen B. Baker Nicholas D. Mitchell University of Alberta, Neurochemical Research Unit, Department of Psychiatry, ... hypothesis of depression states that depression is the result of a functional deficiency of NE and/or 5-HT at central synapses ... may be critical in producing the symptoms of depression. Various other neurochemicals have also been implicated in depression, ...
It has been discovered that women who face postpartum depression have a lower level of the cuddle hormone, oxytocin, while ... could stop pregnant women from struggling with post-natal depression! ... This cuddle chemical, released during sex and breastfeeding, ... New Cuddle Chemical Pill Could Prevent Postpartum Depression ... This cuddle chemical, released during sex and breastfeeding, could stop pregnant women from struggling with post-natal ...
Call 833.753.0866 and learn how a chemical imbalance affects you. ... A chemical imbalance in the brain is a common cause for ... Categories: Depression Treatment, Dual Diagnosis, mental health. May 10, 2021. Tags: chemical imbalancechemical imbalance in ... How Does a Chemical Imbalance Affect Depression?. Depression could be caused by insufficient levels of certain ... Can Correcting a Chemical Imbalance Help with a Dual Diagnosis?. Yes. If you or someone you love are dealing with depression or ...
There is no proven biological cause for depression. Its not genetics and drugs cant solve it. Although drugs succeed in ... chemical imbalance, chronic depression, cure depression, depresion, depressed, depression, depression and anxiety, depression ... symptoms for depression, symptoms of depression, treatment of depression, what cause depression, what is depression, what is ... and treatment, depression disorder, depression help, depression support, depression symptoms, depression treatment, depressive ...
... can probiotics help with depression websites, antibiotics ear infection infant, probiotic drink dannon vanilla ... Comments to "Can probiotics help with depression websites". * gynyg. : 17.09.2015 at 16:57:12 Have a digestive issue that would ... Can probiotics help with depression websites,probiotics research papers pdf viewer,probiotics when do you take them epub, ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
... as a treatment for depression. Spravato comes in nasal spray form meant to be administered weekly or every other week depending ... on the severity of the patients depression. There has been a longstanding need for additional… ... a chemical twin of the dissociative psychedelic/anaesthetic ketamine (Special K), ... US FDA approved chemical twin of dissociative psychedelic ketamine to treat depression. ...
NHS spends £2bn on locums, magic mushrooms to treat depression and the chemical in red meat that raises cholesterol. ... wants to investigate the use of the chemical psilocybin - found in fungi known as magic mushrooms- treat depression. ... magic mushrooms to treat depression and the chemical in red meat that raises cholesterol ... The BBC brings us the news that a chemical found in red meat damages the heart, according to US scientists. A study in the ...
The idea that depression is caused by a lack of the chemical serotonin in the brain launched the multi-billion pound SSRI drug ... The idea that depression is caused by a lack of the chemical serotonin in the brain launched the multi-billion pound SSRI drug ... The idea that depression is caused by a lack of the chemical serotonin in the brain launched the multi-billion pound SSRI drug ... Instead, depression has more to do with brain cell activity, and especially excitatory connections. Normal activity is reduced ...
Depression, Chemical. Known as: depression chemical, Chemical Depression, Chemical Depressions Expand. The decrease in a ... Abstract Although chemical and ionization interferences significantly affect the atomic absorption signal of the alkali metals ... Chemical and ionization interferences in the atomic absorption spectrophotometric measurement of sodium, potassium, rubidium, ... Impaired pulmonary mechanics or depression of the respiratory centers can limit the ventilatory response to inhaled carbon… ...
Healing of drug addiction (chemical drugs, hashish, alcohol) as well as depression. J. K. (32), Murnau (Germany). ... I wanted to get rid of the depression. In November 1994 my mother told a friend that I had been reading the Bible out of ... On the one hand I wanted to get rid of the severe withdrawal symptoms and the depression; on the other hand I was afraid of ... As a result of the many unresolved issues he suffered from strong feelings of fear and depression, which he could not shake off ...
... Julia Forrester • April 30, 2018 • No Comments • ... If youre looking for non-chemical options, you may want to try one of these six options to determine if they are effective for ... Exercising 30 minutes a day at least 3-5 times a week can cause an improvement in depression symptoms. While this may not be ... 2. TMS Therapy for Depression. This non-drug treatment was cleared by the FDA and works by using magnetic pulses to stimulate ...
The discovery of gut bacteria that need the calming chemical GABA to survive could explain why bacteria seem to influence our ... Treating depression. An experiment in 2011 showed that a different type of gut bacteria, called Lactobacillus rhamnosus, can ... Bacteria have been discovered in our guts that depend on one of our brain chemicals for survival. These bacteria consume GABA, ... Having abnormally low levels of GABA is linked to depression and mood disorders, and this finding adds to growing evidence that ...
While some chemical imbalances can be a factor in certain symptoms of mental health conditions, they do not tell the whole ... Research has linked chemical imbalances to some mental health conditions, including:. Depression. Depression, also called ... Catatonic depression: What to know. Catatonic depression is a subtype of depression characterized by not speaking or responding ... Depression with psychosis, or psychotic depression, happens when someone with major depression also experiences psychosis. This ...
Chemical Enlightenment By Bruce Bower. September 26, 2006. * Neuroscience Psilocybin may help cancer patients with depression ... In the new study, patients with moderate or severe depression received two doses of psilocybin pills spaced about a week and a ... The drops in depression symptoms are substantial compared with those found by some analyses of standard antidepressants, ... Psilocybin may help treat depression, a small study finds. Benefits of the compound, found in psychedelic mushrooms, lasted a ...
Because we associate depression with its primary symptom of pervasive sadness, many of us struggle to tell the difference ... Chemical imbalance. Submitted by Brigitte on October 3, 2015 - 11:24am After struggling with both sadness and depression, Ive ... happy , depression anxiety etc. etc chemicals inside our. brains that somehow bring. out those feelings inside our. torso ... depression. Submitted by anonymous on October 23, 2015 - 4:13am I have been told by a trust worthy person that depression and ...
But others suffer much more, and end up with depression and anxiety, among other things. Genetics may play a role, indeed, but ... What is mental illness really? Im beginning to think a lot of mental illness specifically anxiety and depression, especially ...
Chemical Mechanisms of - CHEMICAL BIOLOGY - reflects the multidimensional character of chemical biology, focusing in particular ... on the fundamental science of biological structures and systems, the use of chemical and biological techniques to elucidate ... Fish oils for depression? J. Psychiatry Neurosci. 2008; 33;(E1).. 119. Hypericum Depression Trial Study Group. Effect of ... Neurobiology of depression. Neuron 2002; 34:13-25.. 8. Shelton RC. The molecular neurobiology of depression. Psychiatr. Clin. N ...
... chemical messenger, chronic heartburn, coming panic, cures depression, cures for depression, deficit hyperactivity disorder, ... healing depression, health care, health care profession, health care professional, help for depression, holiday depression, hot ... Cures For Depression Naturally 2018. News, Views & The Other Side Of The Story Www …. depression, naturally • Financial turmoil ... There is a naturally occurring chemical ("neurotransmitter") in the brain called dopamine. Dopamine is the chemical messenger ...
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients. ...
Chemical Reactivity 10th Edition John C. Kotz Chapter 15.6 Problem 2.1ACP. We have step-by-step solutions for your textbooks ... Freezing point depression is one means of determining the molar mass of a compound. The freezing point depression constant of ... What is true about the chemical properties of the product? a. The properties are more like chemical A. b. The p.... Chemistry: ... 16-43 (Chemical Connections 16D) Give two reasons why amine-containing drugs are most commonly administered as .... ...
When internal or external factors either deplete the brain of these chemicals or stimulate it to produce excess amounts, a ... Healthy people possess levels of brain chemicals that lie within a certain normal range. ... Depression. Depression is a symptom of an imbalance in the brains chemistry. In depression, the brain levels of the well-being ... Alcohol furthermore triggers the release of stress chemicals that create depression, distress and tension. This asymmetry ...
The Depression Clinical & Research Program at Massachusetts General Hospital is a leading center for the treatment and study of ... Depression is a treatable illness that may involve an imbalance of brain chemicals called neurotransmitters. Although ... Major Depression. Major depression, also known as clinical depression or unipolar depression, is classified as a type of ... Learn more about symptoms and treatment of depression.. Prevalence of Depression. MDD is the most common form of depression. ...
For example, post-partum depression (peripartum depression) or depression resulting from thyroid problems, menopause ( ... Depression: More than a Brain Chemical Imbalance. When you are feeling sad for a prolonged period of time and you cant find ... What causes depression?. *Brain Chemistry: Our brain uses chemical messengers called neurotransmitters to communicate with its ... People with family history of depression are more likely to suffer from depression. Research is going on to find depression ...
Depression is a real illness, just like diabetes or heart disease. It may be associated with chemical changes in the brain. ... Depression is much more serious than just feeling down. ... Brain chemicals and depression. The brain is a complex organ. ... Depression and the Brains Chemical Balance. Everyone feels sad from time to time. But depression is much more serious than ... A change in chemicals in the brain can interfere with how messages are sent. This is one cause of depression.. ...
  • Stress and the hypothalamic-pituitary-adrenal (HPA) axis play a central role, and it has been proposed that increased secretion of corticotropin releasing factor (CRF) may be critical in producing the symptoms of depression. (
  • These women also answered questions designed to pick up symptoms of depression and were questioned again two weeks after giving birth. (
  • For the past 10 years, Papolos has been prescribing an intranasal form of ketamine for children and adolescents who have a disorder that includes symptoms of depression. (
  • We are conducting a study that examines whether hyperthermic yoga might be a good treatment option for people who are experiencing symptoms of depression. (
  • The symptoms of depression in adults differ from person to person, as no two people are affected the same way. (
  • But that doesn't make the symptoms of depression go away and for a lot of people, neither do antidepressants. (
  • What are the signs and symptoms of depression? (
  • This is sometimes separated from an adjustment disorder, where you may struggle with some symptoms of depression because of adapting to a major change in your life. (
  • Walking daily for 30 minutes helps to reduce symptoms of depression. (
  • As many as 1 in 13 Americans from the age 12 and older report symptoms of depression, according to the Centers for Disease Control and Prevention (CDC) . (
  • If these chemicals change, you may develop symptoms of depression. (
  • Changes in hormones may cause symptoms of depression. (
  • With this level of complexity, you can see how two people might have similar symptoms of depression, but the problem on the inside, and therefore what treatments will work best, may be entirely different. (
  • One of the symptoms of depression is fatigue. (
  • Signs and symptoms of depression most commonly start around age 15 , however signs can be seen as early as childhood. (
  • Some of the neurotransmitters believed to be linked to depression are serotonin , norepinephrine , and dopamine . (
  • Depression could be caused by insufficient levels of certain neurotransmitters in the brain, such as serotonin or dopamine. (
  • Exercise may also help because it causes the brain to release dopamine and other chemicals that may boost a person's mood. (
  • There is a naturally occurring chemical ("neurotransmitter") in the brain called dopamine. (
  • In depression, the brain levels of the well-being hormone serotonin, the reward hormone dopamine and the neurological inhibitor chemical GABA are lower than normal, reports a research team in the March 2010 issue of 'Biological Psychiatry. (
  • Chemicals like serotonin, norepinephrine, and dopamine play an essential role in regulating our mood and unlike what is said. (
  • For the study, Drs. Hanneke den Ouden and Roshan Cools from the Donders Institute and New York University investigated how the brain chemicals dopamine and serotonin help determine our sensitivity to reward and punishment. (
  • As studied by researchers, chemicals such as serotonin, norepinephrine and dopamine - are low in the brain during major depressive episodes and this can caus. (
  • Microorganisms in our gut secrete a profound number of chemicals, and researchers … have found that among those chemicals are the same substances used by our neurons to communicate and regulate mood, like dopamine, serotonin and gamma-aminobutyric acid (GABA). (
  • Indeed, the term ' SSRI ' is itself a misnomer, since some of these agents also affect other brain chemicals - for example, sertraline has mild effects on dopamine . (
  • In a new study of seven people with Parkinson's disease, Johns Hopkins Medicine researchers report evidence that deep brain stimulation using electrical impulses jumpstarts the nerve cells that produce the chemical messenger dopamine to reduce tremors and muscle rigidity that are the hallmark of Parkinson's disease, and increases feelings of well-being. (
  • In 1984, National Institute of Mental Health (N.I.M.H.) researchers began to measure patients' body fluids before and after receiving a course of ECT to determine the levels of three neurotransmitter systems -serotonin, norepinephrine and dopamine - that have been associated with major depression. (
  • It turned out that Parkinson's - a brain disorder - was caused by a deficiency of a chemical in the brain called dopamine . (
  • Researchers in the area of mood disorders believe that chemicals called neurotransmitters are involved in depression. (
  • So researchers are conjuring up a way to boost those levels by creating a pill that contains this "cuddle chemical. (
  • Now doctors and researchers are looking into an idea that would create a pill to boost the "cuddle chemical" during pregnancy to cut out the odds of getting the baby blues. (
  • Despite the popular notion of depression as a chemical imbalance, many researchers say the science doesn't back it up. (
  • Because serotonin can strengthen the communication between brain cells, researchers wrongly believed that its lack was a direct cause of depression. (
  • Although chemical imbalances in the brain seem to have an association with mood disorders and mental health conditions, researchers have not proven that chemical imbalances are the initial cause of these conditions. (
  • While some studies have identified links between distinct chemical imbalances and specific mental health conditions, researchers do not know how people develop chemical imbalances in the first place. (
  • For example, researchers point out that if depression were solely due to chemical imbalances, treatments that target neurotransmitters, such as selective serotonin reuptake inhibitors (SSRIs), should work faster. (
  • Two doses of psilocybin, the active ingredient in hallucinogenic mushrooms, eased people's depression symptoms, researchers found. (
  • Chemical imaging has until now mainly been used for earth sciences and cellular imaging, but with access to human skin from operations the researchers have come up with this new area for the technology. (
  • The "surfactant" chemicals found in samples of fracking fluid collected in five states were no more toxic than substances commonly found in homes, according to a first-of-its-kind analysis by researchers at the University of Colorado Boulder. (
  • The biggest study of its kind has allowed researchers to identify genetic risk factors associated with major depression, providing new insights for prevention and treatment. (
  • Researchers argue that the chemical imbalance hypothesis is more of a figure of speech. (
  • It also offers a better understanding of the relationship between brain chemicals and behavior in healthy people, which will ultimately help provide researchers with a better understanding of neuropsychiatric disorders. (
  • In one experiment designed to investigate the influence of microbes on depression, researchers performed fecal transplants, transferring stool samples from human patients into rats. (
  • Even though depression affects roughly one in 10 Americans and is a leading cause of death and disability, close to half of patients with depression don't get treatment, researchers note in the Journal of Clinical Psychiatry. (
  • To see how patient satisfaction with telemedicine stacked up against in-person therapy for depression, researchers examined data on male and female veterans aged 58 and older. (
  • Now researchers have determined that an alteration known as a single nucleotide polymorphism (SNP) in the BDNF gene may further contribute to the risk of anxiety, depression and memory loss. (
  • Researchers have studied numerous herbs, supplements, and vitamins to determine if they can benefit people with depression. (
  • The impact of exercise on reducing excessive sleepiness in depression is linked to certain chemicals, researchers have found. (
  • This suggests that different biological mechanisms contribute to insomnia - which is more common in typical depression - compared to hypersomnia, the researchers report. (
  • The researchers also found that patients with TBI and depression were more likely to have a history of mood and anxiety disorders than patients with TBI who did not experience depression. (
  • Researchers have learned much about the biology of depression. (
  • And while researchers know more now than ever before about how the brain regulates mood, their understanding of the biology of depression is far from complete. (
  • Researchers believe that - more important than levels of specific brain chemicals - nerve cell connections, nerve cell growth, and the functioning of nerve circuits have a major impact on depression. (
  • Researchers have established a correlation between depression and a group of neurotransmitter-producing bacteria found in the human gut. (
  • Summary: Using mouse models, researchers restricted a key chemical messenger to extend efficient auditory learning until much later in life. (
  • Researchers used a variety of methods to demonstrate that reducing adenosine or blocking the A1 adenosine receptor that is essential to the chemical messenger's function changed how adult mice responded to sound. (
  • Nicotine's primary metabolite supports learning and memory by amplifying the action of a primary chemical messenger involved in both, researchers report. (
  • This does not mean that you are destined to live with chronic clinical depression. (
  • Spence also wrote that 75% of the people defining and endorsing drug treatments for clinical depression are paid by drug companies. (
  • Depression, also called clinical depression, is a mood disorder that affects many aspects of a person's life, from their thoughts and feelings to their sleeping and eating habits. (
  • Clinical depression is a common term, but it is not a formal diagnosis. (
  • If you have a thought that just will NOT go away and it is interupting your daily life, it may be OCD, or it may just be garden variety depression, as clinical depression can make one ruminate like mad, and toss in anxiety and it's a real mess. (
  • BDNF levels are critically low in people with clinical depression, which animal models suggest may actually be a primary contributing cause. (
  • When a patient has clinical depression, she has symptoms like sadness and anger that interfere in her life. (
  • Does clinical depression exist or are people just sad? (
  • Postpartum depression (PPD), is an example of a type of clinical depression that affects women after childbirth. (
  • Depression may be treated with medication and talking treatments. (
  • A start-up is promoting a natural way to combat many dysfunctional feelings and poor mental performance without using chemicals, therapy or medication. (
  • According to the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study , a project funded by the National Institute of Mental Health, if the first choice of medication does not provide adequate symptom relief, switching to a new drug is effective about 25 percent of the time. (
  • In an interview on YouTube's Off-Camera Show , Kristen Bell told Sam Jones she takes medication for depression and anxiety. (
  • Bell's advice for dealing with depression and anxiety: Understand that there's no shame in seeking help, including medication, for mental health conditions. (
  • The importance of the study is fundamental to combating depression, as it is also a known that it is close personal relationships and not medication that are most capable to dealing with the condition in a positive way. (
  • Anti-depression medication is used to treat depression caused by both kinds of factors and is combined with individual and family therapy. (
  • I do know, from my own experience with depression, that I have had good results by taking a medication that works for me and sorting through my ways of solving problems into something far better. (
  • The herb also appears to cause fewer unwanted side effects than traditional depression medication. (
  • Future work can investigate the possibility of SSRI effects by looking at other groups, including people who are not taking any medication for their depression and those who have recovered from depression but still experience disrupted sleep. (
  • Depression usually needs some form of medication to overcome it. (
  • If diagnosed with depression, treatments like psychotherapy, medication and electro-convulsive therapy might help. (
  • No matter how bleak it might seems at times, know that depression is treatable through therapy and prescription medication. (
  • What Is a Chemical Imbalance in the Brain? (
  • A chemical imbalance in the brain happens when the brain has too many or too few neurotransmitters of varied kinds. (
  • A chemical imbalance in the brain occurs when a person has either too little or too much of certain neurotransmitters. (
  • A chemical imbalance in the brain is said to occur when there's either too much or too little of certain chemicals, called neurotransmitters, in the brain. (
  • It's often said that mental disorders, such as depression and anxiety , are caused by a chemical imbalance in the brain. (
  • What are the symptoms of a chemical imbalance in the brain? (
  • The idea that mental disorders are caused by a chemical imbalance in the brain was first proposed by scientists in the late 1950s. (
  • What causes a person to have a chemical imbalance in the brain? (
  • Is there a test to identify a chemical imbalance in the brain? (
  • This mental health issue can also be caused by external factors-not just a natural chemical imbalance in the brain-such as school stress, relationships and family drama. (
  • There are millions of chemical reactions that impact our mood, our memory and how we respond mentally and physically to a stressful situation. (
  • Because everything we ingest, every situation we find ourselves in cause a different emotional response, any imbalance in the chemicals associated with mood set off other reactions in various parts of the brain and body. (
  • Well that's because exercise stimulates the chemicals in your brain such as norepinephrine and serotonin which contribute to good mood. (
  • Having abnormally low levels of GABA is linked to depression and mood disorders, and this finding adds to growing evidence that our gut bacteria may affect our brains . (
  • Such work may eventually lead to new treatments for mood disorders like depression or anxiety . (
  • Bipolar disorder is a mood disorder that causes alternating periods of mania and depression. (
  • It is referred to as the 'happy chemical' because it increases happiness and good mood. (
  • Depression or major depressive disorder is a serious mood disorder accompanied by a never-ending sadness or loss of interest. (
  • Did you know that there are billions of chemical reactions that are responsible for mood? (
  • Chemical dependency is charactereized by addiction to a mood- or mind-altering drug. (
  • But, just because a person's mood can be elevated with drugs that increase brain chemicals doesn't mean that their symptoms were caused by a deficiency in that chemical in the first place. (
  • Depression is a long lasting low mood disorder. (
  • Bipolar disorder is characterized by cycling mood changes - from extreme highs (e.g., mania) to extreme lows (e.g., depression). (
  • The sound technology created by Revolutioner promotes a chemical release in the brain that reduces negative, while the Alpha brainwaves boost your overall mood. (
  • But neither fame nor fortune immunizes celebrities against the ravages of depression and mood disorders. (
  • And it perhaps comes as no surprise to discover that it's the hormones and chemicals that typically influence our mood, sleep, appetite and libido that are the most affected! (
  • Remember, this 'feel-good' chemical affects the part of the brain that regulates mood, appetite and sleep, so boosting levels means you're less likely to feel miserable, overeat or have trouble sleeping. (
  • Depression is a mood disorder in which people experience feelings of sadness, loneliness, and loss of interest for long periods of time. (
  • Unlike people with typical depression, those with the atypical variety may experience improvements in mood following positive events, an increased appetite and/or weight gain, high sensitivity to social interactions and the feeling their limbs are weighed down. (
  • There are millions, even billions, of chemical reactions that make up the dynamic system that is responsible for your mood, perceptions, and how you experience life. (
  • Use of this technology has led to a better understanding of which brain regions regulate mood and how other functions, such as memory, may be affected by depression. (
  • Aromatherapy recipes meant for depression are combinations of different essential oils that are said to uplift the spirit and lighten the mood. (
  • the fact that ADD is a chemical deficiency in the brain (lack of glucose) which makes him 'like a race car going around and around without brakes. (
  • Brain chemicals (neurotransmitters), neuron connections, cell growth, and the functioning of circuits in our brains all have an impact on depression. (
  • Mental health experts believe that depression results from changes in the levels of chemicals in the brain and the body. (
  • In the brain, the chemicals are neurotransmitters. (
  • Depression is a disorder of the brain. (
  • Other chemicals called hormones may affect the delicate balance of chemicals in the brain. (
  • Since anxiety is at the root of depression and the stress to the body becomes cortisol overload, the chemicals in the brain end up screwed up because our normal joy is stopped. (
  • What Causes Chemical Imbalances in the Brain? (
  • Depression is believed to be from a lack of serotonin in the brain, but it's unclear how that chemical becomes imbalanced in some people. (
  • Instead, depression has more to do with brain cell activity, and especially excitatory connections. (
  • This non-drug treatment was cleared by the FDA and works by using magnetic pulses to stimulate the parts of the brain associated with depression and other brain-related disorders. (
  • At Smart Brain and Health , for example, they use Transcranial Magnetic Stimulation by sending repetitive magnetic pulses that stimulate nerve cells that may be underactive in people with depression. (
  • Bacteria have been discovered in our guts that depend on one of our brain chemicals for survival. (
  • A popular hypothesis is that mental health disorders, such as depression and anxiety , develop as a result of chemical imbalances in the brain. (
  • In this article, we discuss conditions with links to chemical imbalances in the brain, myths surrounding this theory, possible treatment options, and when to see a doctor. (
  • It is a popular myth that chemical imbalances in the brain are solely responsible for causing mental health conditions. (
  • Doctors do not, therefore, diagnose mental health conditions by testing for chemical imbalances in the brain. (
  • Although some research links chemical imbalances in the brain to depression symptoms, scientists argue that this is not the whole picture. (
  • Cell loss seems to occur in some brain areas (e.g., hippocampus) in depression, and such loss can be produced by stress and prevented by antidepressants (which also increase expression of various neurotrophic and transcription factors). (
  • Depression has been shown to impact individual quality of life significantly (3), carry a heavy economic burden (4), and affect brain structure and function (5). (
  • Serotonin is a critical brain chemical that is also found in blood platelets and the bowels. (
  • Healthy people possess levels of brain chemicals that lie within a certain normal range. (
  • When internal or external factors either deplete the brain of these chemicals or stimulate it to produce excess amounts, a chemical imbalance occurs. (
  • Our brain uses chemical messengers called neurotransmitters to communicate with its other parts or nervous system. (
  • Any problem or imbalances in the brain related to neurotransmitters have been linked to depression. (
  • Chemical changes in the brain may contribute to the symptoms of the disease. (
  • A change in chemicals in the brain can interfere with how messages are sent. (
  • Brain messages travel with help from chemicals. (
  • No one knows exactly what happens in the brain to cause depression. (
  • Inflammation literally changes how your brain works and unfortunately, depression and mental illness is a part of that for some people. (
  • This idea boils down to the notion that chemicals in the brain, also known as neurotransmitters are defective. (
  • In other words, the chemicals in our brain are only one piece of the whole puzzle. (
  • During long periods of depression, the brain becomes overflooded, leading to memory problems. (
  • Genetics, neurotransmitters, and specific brain regions all contribute to depression. (
  • The novel results of our study represent the first report describing the effect of long-term cholesterol depletion on this type of neurotransmitter receptor and suggest that chronic, low cholesterol levels in the brain may trigger anxiety and depression," Chattopadhyay said a press conference at Hyderabad. (
  • In other words, mental disorders aren't simply caused by chemical imbalances in the brain. (
  • Research at the time had focused on the role that chemicals in the brain play in depression and anxiety. (
  • For example, depression is said to be a result of having too little serotonin in the brain. (
  • As reports, there are likely millions of different chemical reactions occurring in your brain at any given time. (
  • There would be no way to tell if someone truly had a chemical imbalance in their brain at a given time. (
  • There are no reliable tests available to find out if you have a chemical imbalance in your brain. (
  • Depression Due To Brain Chemical Imbalance? (
  • Chemical imbalance from the brain is one of another grounds why a person experiencing depression. (
  • Neurotransmitters, chemicals in our brains that work as messengers between brain cells, are responsible for most of what goes on in our bodies. (
  • While deep brain stimulation is most commonly used to treat patients suffering from neurological disorders such as Parkinson's Disease , trials have been underway to use the procedure to ease cases of major depression and Obsessive Compulsive Disorder (OCD). (
  • Endocannabinoids are essential chemicals found within the brain and are similar to marijuana's cannabinoids. (
  • As we learn about different systems that may contribute to the illness and the complicated mechanisms of the brain, scientists are thinking differently about drugs to treat depression and bipolar disorder . (
  • New evidence has put into doubt the long-standing belief that a deficiency in serotonin - a chemical messenger in the brain - plays a central role in depression . (
  • Depression is associated with reduced levels of chemicals in the brain that transmit signals between nerve cells. (
  • It triggers the release of potent brain chemicals called endorphins which relieve pain and stimulate relaxation. (
  • The brain chemical serotonin has been linked to depression. (
  • It's thought the amount of light that enters the eye affects certain hormones and chemicals in the hypothalamus of the brain. (
  • Many experts believe that low levels of a brain chemical called serotonin may have an important part to play in the winter blues. (
  • Another popular theory is that depression is due to some sort of ' chemical imbalance ' in your brain (more on this later). (
  • BDNF activates brain stem cells to differentiate into new neurons, while also triggering numerous other chemicals that promote neural health. (
  • Electroconvulsive therapy is a medical treatment for severe mental illness (especially severe depression) in which a small, carefully controlled amount of electricity is introduced into the brain. (
  • Many patients who experience a traumatic injury to the brain experience major depression or other psychiatric illnesses within a year after their head injuries, according to two articles in the January issue of The Archives of General Psychiatry, one of the JAMA/Archives journals. (
  • Major depression was also associated with worse social functioning at the six- and twelve-month follow-up, as well as reduced gray matter (a brain structure) volumes on brain scans. (
  • Research suggests that depression doesn't spring from simply having too much or too little of certain brain chemicals. (
  • These medications immediately boost the concentration of chemical messengers in the brain (neurotransmitters). (
  • Depression happens due to chemical changes in the brain, triggered by a confluence of circumstances. (
  • Depression can be triggered by a deeply sad memory, or even by poor diet which slows the production of certain brain chemicals. (
  • This chemical in your brain called serotonin is too, too low. (
  • People with depression have decreased levels of serotonin , a feel-good drug that is naturally produced in the brain. (
  • Depression often has biochemical roots that stem from the destructive effect of alcohol on the normal chemisty of the brain. (
  • My search for an explanation for Rob's suicide led me to studies that confirmed the connections between brain biochemistry and depression and offered methods of repair that succeed far more reliably than any form of talk therapy. (
  • St. Jude Children's Research Hospital scientists have evidence from mice that restricting a key chemical messenger in the brain helps extend efficient auditory learning much later in life. (
  • If cognitive behavior therapy is said to help severe depression, then that indicates it's the person's fault they have this disgusting life sucking illness. (
  • While they are often effective for moderate to severe cases, mild depression may not respond as well to medications. (
  • In the new study, patients with moderate or severe depression received two doses of psilocybin pills spaced about a week and a half apart. (
  • Scores can range from 0 to 52, with higher numbers indicating more severe depression. (
  • Anti-depressants are effective for moderate to severe depression cases. (
  • If you are going through a severe episode of depression, you may get hallucinations or delusions. (
  • But the vast majority, even those with the most severe depression, can get better with treatment. (
  • Dysthymic disorder , also called dysthymia, is characterized by depressive symptoms that are long-term (e.g., two years or longer) but less severe than those of major depression. (
  • Symptoms of minor depression are similar to major depression and dysthymia, but they are less severe and/or are usually shorter term. (
  • This is demonstrably false , at least with respect to moderate-to-severe depression. (
  • In the last 10 years, studies have shown that it can reverse the kind of severe suicidal depression that traditional antidepressants can't treat - and sometimes in the matter of a few hours. (
  • However, two studies found that St. John's wort wasn't effective in mild and severe depression. (
  • The purpose of ECT is to provide relief from the signs and symptoms of mental illnesses such as severe depression, mania, and schizophrenia. (
  • Pregnancy, though, does not protect women from experiencing mild to severe depression. (
  • However, it soon became obvious that other factors were also important in the neurobiology of depression. (
  • There is little question that the role of serotonin in depression was over-emphasized and over-marketed in the 1990s," explains Ron Pies, MD , professor of psychiatry and behavioral sciences at SUNY Upstate Medical University in Syracuse and author of Psychiatry on the Edge , "though most psychopharmacologists understood that the neurobiology of depression was much more complicated. (
  • The drops in depression symptoms are substantial compared with those found by some analyses of standard antidepressants, Griffiths says. (
  • Antidepressants and talk therapy are the main treatments for depression. (
  • Many people with depression after being treated with these types of antidepressants. (
  • One study estimates that current antidepressants on the market only work in about of those with depression. (
  • However, they can be useful in treating depression when newer, safer antidepressants have not been effective. (
  • Taking prescription antidepressants, downing a couple bottles of booze, shooting up or sniffing street drugs - all of these can ultimately let loose an invisible Sorcerer's Apprentice going wild inside the body's chemical laboratory. (
  • It is considered by many psychiatrists to be the most effective way to treat depression especially in patients who haven't responded to antidepressants. (
  • Depression is a symptom of an imbalance in the brain's chemistry. (
  • CBD treats depression by controlling their brain's chemistry. (
  • Your brain's functions are carefully controlled by a delicate balance of chemicals and neurotransmitters. (
  • Major depressive disorder , also called major depression, is characterized by a combination of symptoms that interfere with a person's ability to work, sleep, study, eat, and enjoy once-pleasurable activities. (
  • Research and studies have suggested that if you may be more susceptible to depression if have relatives who have been diagnosed with depression or other mental illness. (
  • Physical and mental illness can predispose someone to depression. (
  • Depression is an abnormal emotional state, a mental illness that affects our thinking, emotions, perceptions, and behaviors in pervasive and chronic ways. (
  • Depression is an extremely common mental illness and there are many treatments that benefit most people. (
  • Depression is a real illness, just like diabetes or heart disease. (
  • defines depression as "a common and serious medical illness that negatively affects how you feel, the way you think and how you act. (
  • But this illness is complex because other factors such as the environment, medical conditions, and stress also play a role in depression. (
  • Depression is a common but serious illness, and most who have it need treatment to get better. (
  • Bipolar disorder , also called manic-depressive illness, is not as common as major depression or dysthymia. (
  • If a woman has a family history of depression, she may be more at risk of developing the illness. (
  • Serotonin as we know aids us in battling depression, it is the 'happy chemical' and the results point to a new finding, in that people with depression could have this illness change those people's perception of personal relationships. (
  • All forms of chemical dependence are an illness like diabetes - not curable by "head talk" or "spiritual rebirth," she observed. (
  • 3] They revealed that the single biggest determinant of chronic anxiety and depression was traumatic life events, followed by to a lesser extent, family history of mental illness, income and education levels, relationship status and other social factors. (
  • Depression is an increasingly common illness. (
  • Like any mental illness, depression is a complex and multifaceted issue. (
  • I had suicidal depression. (
  • Autopsies of people who have committed suicide have revealed biochemical disruptions that may be unique to suicidal depression. (
  • For people who have depression and signs of a substance use disorder, seeking out depression treatment and support could make a big difference in their lives. (
  • Unfortunately, millions of people suffer from depression each year. (
  • This therapy is often effective in people who suffer from a type of depression known as seasonal affective disorder, or the winter blues as it is commonly referred to. (
  • Studies have shown that it can be beneficial in people who suffer from mild depression and also doesn't have negative side effects. (
  • Although many people suffer from depression, there are effective treatment options available that don't involve the use of prescription medications. (
  • At least for some people, psilocybin can reduce depression better than several common treatment options. (
  • In my years of private practice, I've met many people struggling with depression who thought they were merely sad. (
  • In my TED talk , I discussed one of the more unfortunate consequences of this confusion: How people struggling with depression are often expected to "snap out of it," and are told "it's all in your head," or "choose to be happy! (
  • To be diagnosed with depression, people need to have at least 5 of the following symptoms, for a continual duration of at least two weeks. (
  • Depression is a common and a widely observed mental disorder which affects people of all ages. (
  • As per WHO, more than 300 million people worldwide suffer from depression. (
  • People with family history of depression are more likely to suffer from depression. (
  • People who had faced depression prior in their lives appear to have some physical changes in their brains triggering the risk of being depressed. (
  • Pessimists and people with low self-esteem are also more likely to experience depression. (
  • Some people with depression have low levels of this. (
  • But in those with depression it starts acting out, flooding people with threats that will eventually lead to feelings of hopelessness. (
  • Depression affects different people in different ways. (
  • People may say that they are feeling depressed when they are feeling down, but this does not always mean that they have depression. (
  • Depression can affect people of any age, including children. (
  • The number of people who have depression may be higher than this because not everyone with depression goes to their GP. (
  • People with dysthymia may also experience one or more episodes of major depression during their lifetimes. (
  • These days, people prefer Mediluxe Chemical Peel to brighten the dull skin and remove unwanted spots in the body. (
  • Some people go for 70% lactic acid peel, while others prefer TCA chemical peel. (
  • Many people think that chemical peel is used only in facial treatment, but in fact this technique can be used for other parts of the body such as neck, hands, chest and legs. (
  • Reported to affect one in every ten American people , depression is a potentially-fatal mental health condition that has America in the grip of an epidemic. (
  • When depression goes untreated, it's often because people can't overcome issues with mobility, travel distance, transportation costs or time off work - all of which may be addressed by telemedicine. (
  • Two years ago, I talked with a prominent psychiatrist about what could be done for all the people who have treatment-resistant depression who do not respond - or only partially respond - to the drugs on the market today. (
  • In an April 2015 editorial in The BMJ, 'Serotonin and Depression: The Marketing of a Myth ,' professor of psychiatry David Healy, MD , explained that there was no correlation between serotonin reuptake-inhibiting potency and antidepressant effectiveness, and that the low-serotonin story is a myth to make people feel better that depression is not a weakness. (
  • In another post, I discussed ketamine ( Ketalar ), which some people are hailing as a miracle drug for depression . (
  • The scrutiny that young people face on social media can lead to anxiety, depression, and even suicidal thoughts," he says. (
  • Because of Gaga's own struggles with depression and feelings of isolation, her mission is to help young people facing similar emotional struggles. (
  • Her Born This Way Foundation aims to empower youth and inspire bravery, and provides resources to help young people affected by bullying, abuse, and depression. (
  • Still, he hopes that people with depression don't give up hope during dark times. (
  • Smartphone overuse by young people is linked to an increased risk of later depression, finds a new University of Arizona study. (
  • The reasons are also suggested: reliance on smartphones for social support and intimacy reduces the extent of significant communication between people offline, leading to a greater sense of loneliness and depression. (
  • The doctor feels that the alterations in chemical levels actually change the way that people think about their partners and their relationships with them. (
  • A clinical psychologists' tool was used to identify those people at risk for mental problems, such as depression. (
  • Whilst we know that a person's genetics and life circumstances contribute to mental health problems, the results showed that traumatic life events are the main reason people suffer from anxiety and depression. (
  • People with depression may have physical changes in their brains. (
  • Similarly, though IL-1β generally improves sleep, the new results indicate that this chemical may be overproduced in atypically depressed people and reduced by exercise, thus lessening symptoms of hypersomnia. (
  • Experts have long wondered why, if depression were primarily the result of low levels of neurotransmitters, people don't feel better as soon as levels of neurotransmitters increase. (
  • There is no doubt in my mind that the Parkinson's story had a strong impact on the way that people were thinking about depression," Frazer says. (
  • Most people, who suffer from chronic tiredness, can be helped by understanding more about depression and the best ways to treat it according to its specific cause. (
  • Depression is present in more than 50% of people with clinical hypothyroidism. (
  • As nearly 80% of people with adrenal insufficiency are depressed, the link between this condition and depression is strong. (
  • No amount of counseling or psychotherapy can help people who suffer from biochemically induced depression. (
  • These are selective serotonin reuptake inhibitors [SSRIs] and must not be considered as the first line of treatment for mild depression cases, and children. (
  • Online Depression Screening Test tells if you have mild or chronic depression based on your depression symptoms. (
  • Thus, we aim to explore how GP affected chronic unpredictable mild stress (CUMS)-induced depression-like behaviors in mice in vivo and in vitro and the downstream molecular mechanism related to Six3os1. (
  • The study found that the herb failed to improve mild depression. (
  • Depression and Schizophrenia. (
  • 5 , 6 Gastrointestinal abnormalities have been linked to a variety of psychological problems, including depression, anxiety , hyperactivity and schizophrenia . (
  • Perhaps it is no coincidence, then, that exercise is also one of the best-known treatments for depression. (
  • In this guide, learn about the most widely studied alternative treatments for depression. (
  • For those whose body have a genetic problem like bipolar and chronic depression, (and lots of other serious conditons) the system is out of whack and cannot repair itself. (
  • Many doctors who have become comfortable offering ketamine for depression probably won't switch to esketamine, said Dr. Demitri Papolos, director of research for the Juvenile Bipolar Research Foundation and a clinical associate professor at Albert Einstein College of Medicine. (
  • Bipolar disorder is characterized by episodes of elation countered by depression. (
  • Bright light therapy can ease bipolar depression in some patients, according to a study published in the journal Bipolar Disorders. (
  • Researcher Pengfei Zhao says, "If depression and loneliness lead to smartphone dependency, we could reduce dependency by adjusting people's mental health. (
  • Serotonin activity may affect people's ability in depression to maintain positive or intimate personal relationships. (
  • The study, reported in The Journal of the American Medical Association , 'found no evidence of an association between the serotonin gene and the risk of depression, no matter what people's life experience was. (
  • Depression affects both men and women, but more women than men are likely to be diagnosed with depression in any given year. (
  • Do you believe that depression only affects women, or that it's not a medical condition? (
  • This cuddle chemical, released during sex and breastfeeding, could stop pregnant women from struggling with post-natal depression! (
  • Geniposide (GP) has been revealed to play a significant role in depression treatment. (
  • Areas that play a significant role in depression are the amygdala, the thalamus, and the hippocampus (see Figure 1). (
  • Stress, which plays a role in depression, may be a key factor here, since experts believe stress can suppress the production of new neurons (nerve cells) in the hippocampus. (
  • Coyle, who is also the editor of the journal Archives of General Psychiatry , says that though serotonin plays a role in depression, low serotonin is likely not the cause of depression. (
  • Combined with therapy, new ways to think and handle the worrying are learned and the anxiety and depression will be easier to manage. (
  • It is used off-label in multiple sclerosis to treat neuropathic pain (dysesthesias), anxiety and depression. (
  • Just as the reasons and contributing factors are different for everyone, treatment of their depression should consist of a combination of treatment. (
  • Understanding the depression can help you to talk to your doctor about finding the right treatment. (
  • Are There Ways to Correct Chemical Imbalances Through Mental Health Treatment? (
  • Earlier today, the FDA approved esketamine (brand name Spravato), a chemical twin of the dissociative psychedelic/anaesthetic ketamine (Special K), as a treatment for depression. (
  • There has been a longstanding need for additional effective treatments for treatment-resistant depression, a serious and life-threatening condition," said the FDA's acting director of the Division of Psychiatry Products, Dr. Tiffany Farchione, in a press release . (
  • If you've suffered from depression in the past and want to prevent a relapse, then using a mindfulness-based cognitive therapy with meditation may be an effective treatment. (
  • Our confusion can lead us to neglect a serious condition that requires treatment (depression) or, on the other end of the spectrum, overreact to a normative emotional state (sadness). (
  • Intermountain's Dayspring Chemical Dependency Program offers evidence-based treatment. (
  • Either GP treatment or overexpression of Six3os1 or Fezf1 alleviated depression-like behaviors of CUMS-induced mice. (
  • Collectively, GP treatment-mediated Six3os1 upregulation ameliorated oxidative stress of mice with depression-like behaviors via the miR-511-3p/Fezf1/AKT axis. (
  • Additionally, microRNAs (miRNAs) are emerging as a potential treatment strategy for depression due to its capacity in influencing neuronal physiology ( Hansen and Obrietan, 2013 ). (
  • Chemical peel treatment is a lengthy and costly process, which improves the appearance of the skin on the face, neck or hands. (
  • A fascinating article published October 15 in The Economist , ' Novel Drugs for Depression ,' discusses where we've been in terms of drug treatment for depression , and the wide road ahead of us. (
  • At UVRMC, 80-90 percent of the children and adolescents being treated by the Behavioral Medicine Unit suffer from depression, although many were initially brought to the hospital for treatment of another problem, such as a suicide attempt or drug abuse. (
  • These days, MAOIs are not often prescribed as the first treatment for depression . (
  • Measure the reduction of post partum depression after intervention at 6 months and 12 months post treatment. (
  • This study explores the co-location of depression treatment within nurse home visitation and the organizational changes needed to maintain access to evidence-based treatment. (
  • Problem Solving Tools (PST) was chosen as the depression treatment because it is well suited for use by non-mental health specialists and for in-home treatment. (
  • In the first part of the study we will gather information from women and their providers to determine what system and treatment modifications are needed to effectively deliver acceptable depression treatment in home visitation programs. (
  • Build protocols for targeting depression treatment to the woman's symptom severity and patient preferences. (
  • Traditional depression treatment uses a combination of prescription medicines and counseling or therapy. (
  • However, the FDA hasn't approved St. John's wort as a treatment for depression in the United States. (
  • Research is mixed on the effectiveness of this herb for depression treatment. (
  • ECT - more colloquially known as shock treatment - is now accepted by growing numbers of psychiatrists as the preferred treatment for major depression and mania for patients who cannot take or do not respond to medicine. (
  • Or you may need drug treatment to correct a medical condition that can precipitate depression. (
  • Several relapse warning signs appear before you fall completely back into chemical dependency. (
  • The answer is that smartphone dependency predicts the later development of depression . (
  • The study is based on earlier research which indicates that Internet dependency, more or less similar to smartphone dependency, is a predictor of depression and loneliness. (
  • Knowing which way the relationship between depression or mental ill health and smartphone dependency is critical in devising the right corrective measures to fix the problem. (
  • But if smartphone dependency (precedes depression and loneliness), which is what we found, we can reduce smartphone dependency to maintain or improve wellbeing. (
  • VA diagnoses: anxiety, chemical dependency, depression and PTSD. (
  • If you're wondering if the symptoms you're having are caused by a chemical imbalance, it's important to know that there's quite a bit of controversy surrounding this theory. (
  • Because we associate depression with its primary symptom of pervasive sadness, many of us struggle to tell the difference between these two common psychological states. (
  • Depression, for me, wasn't sadness. (
  • Depression is part sadness and part anxiety. (
  • I learned this the hard way: watching my son fight the deep sadness and feelings of hopelessness that descended upon him as his depression worsened. (
  • An imbalance may lead to different types of mental health issues such as anxiety, depression, or other disorders. (
  • The Depression Clinical & Research Program (DCRP) at Massachusetts General Hospital is considered one of the leading centers for the study of unipolar depressive disorders worldwide. (
  • The Depression Clinical and Research Program (DCRP), under the direction of David Mischoulon, MD, PhD , is a leader worldwide in the study of unipolar depressive disorders. (
  • The chemical imbalance theory is unproven and often cited as an explanation for mental disorders. (
  • Mental disorders aren't diagnosed with chemical tests. (
  • These, in turn, appear to play a function in intestinal disorders, which coincide with high levels of major depression and anxiety. (
  • There can be a heritable component to these diseases and it makes sense that a common variant in a gene could be involved … Just like hypertension contributes to the risk for heart disease, the BDNF alteration increases the risk of depression, anxiety and memory disorders - but is not the sole reason why they occur. (
  • In a conversation for this series, Moshfegh explained how the lyrics to "Going Nowhere" recall her own struggles with depression, eating disorders, and ennui. (
  • For centuries, St. John's wort has been used to treat a variety of health conditions, including depression and mental health disorders. (
  • If depression could be cured by improving an imbalance, there would be a much higher success rate for the current antidepressant medications on the market today. (
  • Studies have shown that saffron can increase your levels of serotonin and may be just as effective as some medications when it comes to reducing depression. (
  • There are also much fewer side effects when using saffron than some depression medications. (
  • The most common evidence used to support the chemical imbalance theory is the effectiveness of antidepressant medications. (
  • But given its tremendous success (75 percent) in treating patients who have been resistant to other depression medications , new ketamine-related treatments are emerging. (
  • Depression medications (SSRIs) can do some wonderful changes. (
  • If that's the case, depression medications could be developed that specifically promote neurogenesis, with the hope that patients would see quicker results than with current treatments. (
  • The biogenic amine (monoamine) hypothesis of depression states that depression is the result of a functional deficiency of NE and/or 5-HT at central synapses. (
  • According to pharma and their hired experts, depression is not caused by life experiences, emotional wounding by abuse or loss, disappointments, stress or heartbreak, but an imbalance of neurotransmitters causing serotonin deficiency, and is cured by increased serotonin. (
  • That some feel better when taking an SSRI is not proof that a deficiency causes depression. (
  • It became easy to speculate that depression was due to a deficiency. (
  • Since 1989, WDDTY has provided thousands of resources on how to beat asthma, arthritis, depression and many other chronic conditions. (
  • Research is going on to find depression causing genes. (
  • Genes can determine how vulnerable you are to depression, though it's important to note that even if you have the gene it doesn't mean you will automatically have depression. (
  • We also need to consider a person's history, their environment, past and current events and situations, understand medical history, family history and their typical behaviors to effectively treat depression. (
  • There are several ways to attempt to correct chemical imbalances to treat the symptoms of anxiety, depression, and other conditions. (
  • A former Government drugs tsar, has been awarded more than £5000,000 of public money to carry out a world-first trial using magic mushrooms to treat depression , the Daily Mail reports. (
  • Professor David Nutt, who was sacked in 2009 over views that ecstasy and LSD were less harmful than alcohol, wants to investigate the use of the chemical psilocybin - found in fungi known as 'magic mushrooms'- treat depression. (
  • The FDA has approved several anti-depressants to treat depression. (
  • Are you interested in finding a new way to treat your depression? (
  • If so, you may be eligible to participate in a study using hyperthermic yoga (hot yoga) to treat depression. (
  • They are sometimes referred to as irreversible monoamine oxidase inhibitors , and can be used to treat depression in adults. (
  • If you're interested in trying an alternative therapy to treat your depression, talk with your doctor, therapist, or psychiatrist. (
  • It is used off-label in MS to treat depression. (
  • What are the merits of drug therapy over talk therapy to treat depression and vice-versa? (
  • At my clinic, we treat seven different sources of depression affecting alcoholics. (
  • It's believed that a combination of genetic, biological, environmental, and psychological factors cause depression. (
  • Teenage depression, for example - teenage being a phase of life characterized by a lot of physical and psychological changes, it's during the teenage years that life seems to be taking an all new shape and it gets difficult at times to cope up with these changes within and around you. (
  • The causes of depression range from nutritional, psychological, and circumstantial. (
  • Nerve impulses cause the release of chemicals from one nerve cell, or neuron, to the next, allowing cells to communicate with one another. (
  • Neurotransmitters are the chemical messengers that pass information between nerve cells. (
  • Affecting nerve impulses between neurons, leading to depression. (
  • Neurotransmitters are natural chemicals that help facilitate communication between your nerve cells. (
  • Rather, many chemicals are involved, working both inside and outside nerve cells. (
  • In his article, Against Biologic Psychiatry Kaiser wrote that patients have "been diagnosed with chemical imbalances despite the fact that no test exists to support such a claim , and that there is no real conception of what a correct chemical balance would look like. (
  • What's more, celebrities often experience key risk factors for depression , including substance abuse, sleep disruption, unemployment, and highly variable work schedules, says Scott A. Langenecker, PhD , associate professor of psychiatry and psychology and director of the cognitive neuroscience center at the University of Illinois in Chicago. (
  • In the journal ACS Chemical Neuroscience , scientists have reported that mice lacking the ability to make serotonin in their brains (and thus will have been "depressed" by conventional wisdom) did not show depression-like symptoms . (
  • Childbirth, the menstrual period, and menopause all cause hormonal changes that may be linked to depression. (
  • Depression among women increases during times of hormonal change, such as after childbirth. (
  • The dramatic hormonal changes that take place after giving birth are among the factors that can increase a woman's risk of developing postpartum depression. (
  • An imbalance in hormonal levels may trigger depression. (
  • The onset of depression is far more complex than a chemical imbalance. (
  • Sometimes, depression strikes suddenly, but often the onset is gradual. (
  • On the other hand, many northern Europeans tend to become alcoholics due to a genetic predisposition toward depression, from childhood on. (
  • If a close relative has been diagnosed with depression, you may have a genetic predisposition to developing depression as well. (
  • Treating depression with video conference calls may offer symptom improvement similar to in-person visits, a recent U.S. study suggests. (
  • Hypersomnia is a common symptom of what is known as atypical depression. (
  • These chemicals can affect you in many ways, including your energy level, your feelings, your eating habits, and even your sleeping patterns. (
  • Men in particular are inclined to attribute the feelings induced by depression to other causes. (
  • In the body, the chemicals are hormones. (
  • The potential relationship between depression and hormones focuses on 3 main areas: the fight-or-flight response, the thyroid hormones, and the sex hormones. (
  • The thyroid gland produces important hormones that can affect depression. (
  • Sex hormones , especially female hormones, may be associated with depression. (
  • When less light enters the eye - as is the case with shorter, darker days - imbalances in these hormones and chemicals occur. (
  • For example, post-partum depression (peripartum depression) or depression resulting from thyroid problems, menopause (premenstrual dysphoric disorder) or other conditions. (
  • Oftentimes you hear about depression or anxiety running in families, which leads to an assumption that your genetics may be to blame. (
  • Adolescent depression is an ailment that occurs during the teenage characterized by persistent melancholy, disappointment and loss of self-esteem. (
  • Depression symptoms include bouts of feeling low, frustration and low self-esteem. (
  • Is low self esteem and depression related in any way? (
  • New 'Cuddle Chemical' Pill Could Prevent Postpartum Depression! (
  • It has been discovered that women who face postpartum depression have a lower level of the "cuddle hormone," oxytocin, while they are pregnant. (
  • The research found a clear link between low oxytocin levels and postpartum depression symptoms. (
  • According to the National Institute of Mental Health , 10-15% of women experience postpartum depression. (
  • Drug companies like Pfizer sold the public the simple "chemical imbalance" theory for depression in the late 1980s and 1990s because it's easy to understand: A shortage of neurotransmitters like serotonin could be replenished with a class of drugs called selective serotonin reuptake inhibitors (SSRIs) . (
  • SSRIs can change levels of immune system chemicals and BDNF. (
  • A community of psychiatrists, scientists, experts and professors say that big pharma has been marketing depression, framing it as a biological disease in order to sell drugs, and the experts who've publicly endorsed them just happen to be on their payroll. (
  • Approximately six months later hard drugs started circulating in our group and first I tested Speed, a white, purely chemical powder. (
  • Scientists at the Centre for Cellular and Molecular Biology (CCMB) have revealed that long-term intake of anti-cholesterol drugs called statins increase the risk of anxiety and major depression in patients. (
  • However, in both cases to get over the initial depression drugs surely should be recommended. (
  • Although the etiology of depression remains to be elucidated, our knowledge of the neurobiology and biochemistry of this mental disorder has been updated increasingly. (
  • One limitation of the study is the exclusion of patients with substance abuse issues, acute mental health problems or dementia, which the authors note may restrict how much the findings apply to many patients with depression. (
  • Silverman said in Glamour that she herself has struggled with depression, and takes small doses of Zoloft (sertraline) to maintain her mental health without losing the highs and lows that fuel her creativity. (
  • Secondly, this age group is especially prone to depression, among other mental health issues. (
  • According to the Mental Health Foundation, one person in 100 suffers from Seasonal Affective Disorder or SAD, a form of depression that tends to occur from September to April. (
  • Freezing point depression is one means of determining the molar mass of a compound. (
  • The freezing point depression constant of benzene is −5.12 °C/ m . (
  • When a 0.503 g sample of the white crystalline dimer is dissolved in 10.0 g benzene, the freezing point of benzene is decreased by 0542 °C. Verify that the molar mass of the dimer is 475 g/mol when determined by freezing point depression. (
  • Explain why the dissociation equilibrium causes the freezing point depression calculation to yield a lower molar mass for the dimer. (
  • Dissociation equilibrium causes the freezing point depression to yield a lower molar mass has to be explained. (
  • The freezing point depression osmometer is a variety of osmometers that is used in determining a solution's osmotic strength as its osmotically active aspects depress its freezing point. (
  • Freezing point depression osmometry is, however, the most preferred in distinct contexts. (
  • The osmometer uses the solution's freezing point depression to establish its strength. (
  • Freezing point depression osmometer will be applied in determining a solution's osmotic strength. (
  • The freezing point depression osmometer is calibrated using standards that are within the solution's osmolality range. (
  • Freezing point depression osmometer is applied in various areas in the medical field. (
  • Freezing-point depression is a drop in the temperature at which a substance freezes, caused when a smaller amount of another, non-volatile substance is added. (
  • The resulting liquid solution or solid-solid mixture has a lower freezing point than the pure solvent or solid because the chemical potential of the solvent in the mixture is lower than that of the pure solvent, the difference between the two being proportional to the natural logarithm of the mole fraction. (
  • Freezing-point depression is what causes sea water, (a mixture of salt and other compounds in water), to remain liquid at temperatures below 0 °C (32 °F), the freezing point of pure water. (
  • The phenomenon of freezing-point depression has many practical uses. (
  • The freezing-point depression prevents radiators from freezing in winter. (
  • Freezing-point depression is used by some organisms that live in extreme cold. (
  • With the formula below, freezing-point depression can be used to measure the degree of dissociation or the molar mass of the solute. (
  • Studies have shown that when this often-called fight-or-flight stress response is activated frequently, it may lead to depression. (
  • Different things can lead to depression. (
  • These emotions can lead to depression and anxiety, which can, in turn, hamper your job search efforts. (
  • Some signs of depression are feeling low, feeling bad about yourself and not wanting to do things. (
  • The rats who received stool from patients diagnosed with depression rapidly began exhibiting signs of depression and anxiety. (
  • Interestingly, the mice were compulsive and extremely aggressive, but didn't show signs of depression-like symptoms. (
  • If you have been showing some signs of depression lately, it is advisable that you take a depression test to find out. (
  • What follows is an overview of the current understanding of the major factors believed to play a role in the causes of depression. (
  • What are the symptoms and causes of depression and what are the best treatments for it? (