Glucose
Antimetabolites
Monosaccharide Transport Proteins
Autoradiography
Fluorodeoxyglucose F18
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
Glycolysis
A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.
3-O-Methylglucose
Biological Transport
Hexokinase
An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.
Carbon Radioisotopes
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Glucose-6-Phosphate
Glucose Transporter Type 1
Glucose Transporter Type 4
A glucose transport protein found in mature MUSCLE CELLS and ADIPOCYTES. It promotes transport of glucose from the BLOOD into target TISSUES. The inactive form of the protein is localized in CYTOPLASMIC VESICLES. In response to INSULIN, it is translocated to the PLASMA MEMBRANE where it facilitates glucose uptake.
Tomography, Emission-Computed
Biological Transport, Active
Fluorine Radioisotopes
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Radiopharmaceuticals
Adenosine Triphosphate
Mannose
Tolazamide
Phosphoenolpyruvate Sugar Phosphotransferase System
The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.
Receptor, Insulin
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
Muscle, Skeletal
Sodium Azide
4-Chloro-7-nitrobenzofurazan
Rats, Inbred Strains
Positron-Emission Tomography
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Fructose
Muscle Proteins
Glucokinase
Galactose
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
Iodoacetates
Antimycin A
Energy Metabolism
Galectin 4
Adipocytes
Rats, Sprague-Dawley
Cells, Cultured
Adipose Tissue
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Phosphorylation
Cyanides
Glucose Transport Proteins, Facilitative
Lactic Acid
Myocardium
Carbohydrate Metabolism
Cell Membrane
Arsenite Transporting ATPases
Aminoimidazole Carboxamide
Iodoacetic Acid
2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages II. Dissociation of the inhibitory effects of 2-deoxyglucose on phagocytosis and ATP generation. (1/2660)
Macrophages incubated in 2-deoxy-D-glucose (2-dG)-containing medium showed a marked decrease in cellular ATP content, and were unable to ingest IgG- and complement-coated erythrocytes via the corresponding membrane receptors for these ligands. However, the inhibitory effects of 2-dG on Fc- and C3 receptor-mediated phagocytosis were not a consequence of lowered macrophage ATP levels since addition of glucose or mannose to the culture medium restored the capacity of the macrophages to ingest IgG- and C3-coated particles without increasing ATP levels. These results indicate that Fc- and C3 receptor-mediated phagocytosis (opsonin dependent) differs qualitatively from the ingestion of latex and zymosan particles (opsonin independent); they suggest that the same regulatory molecules govern the responses of phagocytic cells to signals initiated by both the Fc and C3 receptors. The possibility that these molecules are regulated by glycosylation is discussed. (+info)The biological clock of very premature primate infants is responsive to light. (2/2660)
Each year more than 250,000 infants in the United States are exposed to artificial lighting in hospital nurseries with little consideration given to environmental lighting cycles. Essential in determining whether environmental lighting cycles need to be considered in hospital nurseries is identifying when the infant's endogenous circadian clock becomes responsive to light. Using a non-human primate model of the developing human, we examined when the circadian clock, located in the hypothalamic suprachiasmatic nuclei (SCN), becomes responsive to light. Preterm infant baboons of different ages were exposed to light (5,000 lux) at night, and then changes in SCN metabolic activity and gene expression were assessed. After exposure to bright light at night, robust increases in SCN metabolic activity and gene expression were seen at ages that were equivalent to human infants at 24 weeks after conception. These data provide direct evidence that the biological clock of very premature primate infants is responsive to light. (+info)Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. (3/2660)
Platelets express leukotriene (LT) C4 synthase and can thus participate in the formation of bioactive LTC4. To further elucidate the relevance of this capability, we have now determined the capacity of human platelets to export LTC4. Endogenously formed LTC4 was efficiently released from human platelets after incubation with LTA4 at 37 degrees C, whereas only 15% of produced LTC4 was exported when the cells were incubated at 0 degrees C. The activation energy of the process was calculated to 49.9 +/- 7.7 kJ/mol, indicating carrier-mediated LTC4 export. This was also supported by the finding that the transport was saturable, reaching a maximal export rate of 470 +/- 147 pmol LTC4/min x 10(9) platelets. Furthermore, markedly suppressed LTC4 transport was induced by a combination of the metabolic inhibitors antimycin A and 2-deoxyglucose, suggesting energy-dependent export. The presence in platelets of multidrug resistance-associated protein 1 (MRP1), a protein described to be an energy-dependent LTC4 transporter in various cell types, was demonstrated at the mRNA and protein level. Additional support for a role of MRP1 in platelet LTC4 export was obtained by the findings that the process was inhibited by probenecid and the 5-lipoxygenase-activating protein (FLAP) inhibitor, MK-886. The present findings further support the physiological relevance of platelet LTC4 production. (+info)Mannose inhibits Arabidopsis germination via a hexokinase-mediated step. (4/2660)
Low concentrations of the glucose (Glc) analog mannose (Man) inhibit germination of Arabidopsis seeds. Man is phosphorylated by hexokinase (HXK), but the absence of germination was not due to ATP or phosphate depletion. The addition of metabolizable sugars reversed the Man-mediated inhibition of germination. Carbohydrate-mediated regulation of gene expression involving a HXK-mediated pathway is known to be activated by Glc, Man, and other monosaccharides. Therefore, we investigated whether Man blocks germination through this system. By testing other Glc analogs, we found that 2-deoxyglucose, which, like Man, is phosphorylated by HXK, also blocked germination; no inhibition was observed with 6-deoxyglucose or 3-O-methylglucose, which are not substrates for HXK. Since these latter two sugars are taken up at a rate similar to that of Man, uptake is unlikely to be involved in the inhibition of germination. Furthermore, we show that mannoheptulose, a specific HXK inhibitor, restores germination of seeds grown in the presence of Man. We conclude that HXK is involved in the Man-mediated repression of germination of Arabidopsis seeds, possibly via energy depletion. (+info)Developmental regulation of genes mediating murine brain glucose uptake. (5/2660)
We examined the molecular mechanisms that mediate the developmental increase in murine whole brain 2-deoxyglucose uptake. Northern and Western blot analyses revealed an age-dependent increase in brain GLUT-1 (endothelial cell and glial) and GLUT-3 (neuronal) membrane-spanning facilitative glucose transporter mRNA and protein concentrations. Nuclear run-on experiments revealed that these developmental changes in GLUT-1 and -3 were regulated posttranscriptionally. In contrast, the mRNA and protein levels of the mitochondrially bound glucose phosphorylating hexokinase I enzyme were unaltered. However, hexokinase I enzyme activity increased in an age-dependent manner suggestive of a posttranslational modification that is necessary for enzymatic activation. Together, the postnatal increase in GLUT-1 and -3 concentrations and hexokinase I enzymatic activity led to a parallel increase in murine brain 2-deoxyglucose uptake. Whereas the molecular mechanisms regulating the increase in the three different gene products may vary, the age-dependent increase of all three constituents appears essential for meeting the increasing demand of the maturing brain to fuel the processes of cellular growth, differentiation, and neurotransmission. (+info)Endothelin stimulates glucose uptake and GLUT4 translocation via activation of endothelin ETA receptor in 3T3-L1 adipocytes. (6/2660)
Endothelin-1 (ET-1) is a 21-amino acid peptide that binds to G-protein-coupled receptors to evoke biological responses. This report studies the effect of ET-1 on regulating glucose transport in 3T3-L1 adipocytes. ET-1, but not angiotensin II, stimulated glucose uptake in a dose-dependent manner with an EC50 value of 0.29 nM and a 2.47-fold stimulation at 100 nM. ET-1 stimulated glucose uptake in differentiated 3T3-L1 cells but had no effect in undifferentiated cells, although ET-1 stimulated phosphatidylinositol hydrolysis to a similar degree in both. The 3T3-L1 cells expressed approximately 560,000 sites/cell of ETA receptor, which was not altered during differentiation. Western blot analysis and immunofluorescence staining show that ET-1 stimulated the translocation of insulin-responsive aminopeptidase and GLUT4 to the plasma membrane. The effect of ET-1 on glucose uptake was blocked by A-216546, an antagonist selective for the ETA receptor. ET-1 treatment did not induce phosphorylation of insulin receptor beta-subunit, insulin receptor substrate-1, or Akt but stimulated the tyrosyl phosphorylation of a 75-kDa protein. Genistein (100 microM), an inhibitor of tyrosine kinases, inhibited ET-1-stimulated glucose uptake. Our results show that ET-1 stimulates GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes via activation of ETA receptor. (+info)High concentration of glucose decreases glucose transporter-1 expression in mouse placenta in vitro and in vivo. (7/2660)
Facilitative glucose transporter-1 (GLUT1) is expressed abundantly and has an important role in glucose transfer in placentas. However, little is known about the regulation of GLUT1 expression in placental cells. We studied the changes in placental GLUT1 levels in relation to changes in glucose concentration in vitro and in vivo. In in vitro experiments, dispersed mouse placental cells were incubated under control (5.5 mM) and moderately high (22 mM) glucose concentrations, and 2-deoxyglucose uptake into cells was studied on days 1-5 of culture. After 4 days of incubation under both conditions, GLUT1 mRNA and proten levels were examined by Northern and immunoblot analyses. Treatment of cells with 22 mM glucose resulted in a significant decrease in 2-deoxyglucose uptake compared with control, from day 2 to day 5 of culture. Moreover, GLUT1 mRNA and protein levels on day 4 of culture were significantly reduced in cells incubated with 22 mM glucose compared with control. Next, we rendered mice diabetic by administering 200 micrograms/g body weight streptozotocin (STZ) on day 8 of pregnancy. Animals were killed on day 12 of pregnancy and placental tissues were obtained. [3H]Cytochalasin B binding study was carried out to assess total GLUTs, and GLUT1 mRNA and protein were measured as above. [3H]Cytochalasin B binding sites in placentas from STZ-treated mice were significantly less than those in control mice. Northern and immunoblot analyses revealed a significant decrease in GLUT1 mRNA and protein levels in diabetic mice compared with the controls. These findings suggest that the glucose concentration may regulate the expression of placental GLUT1. (+info)Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats. (8/2660)
Previous studies have demonstrated that the ventromedial hypothalamus (VMH) plays a critical role in sensing and responding to systemic hypoglycemia. To evaluate the mechanisms of defective counterregulation caused by iatrogenic hypoglycemia and diabetes per se, we delivered 2-deoxy-glucose (2-DG) via microdialysis into the VMH to produce localized cellular glucopenia in the absence of systemic hypoglycemia. Three groups of awake chronically catheterized rats were studied: 1) nondiabetic (with a mean daily glucose [MDG] of 6.9 mmol/l) BB control rats (n = 5); 2) chronically hypoglycemic nondiabetic (3-4 weeks, with an MDG of 2.7 mmol/l) BB rats (n = 5); and 3) moderately hyperglycemic insulin-treated diabetic (with an MDG of 12.4 mmol/l) BB rats (n = 8). In hypoglycemic rats, both glucagon and catecholamine responses to VMH glucopenia were markedly (77-93%) suppressed. In diabetic rats, VMH 2-DG perfusion was totally ineffective in stimulating glucagon release. The epinephrine response, but not the norepinephrine response, was also diminished by 38% in the diabetic group. We conclude that impaired counterregulation after chronic hypoglycemia may result from alterations of the VMH or its efferent pathways. In diabetes, the capacity of VMH glucopenia to activate the sympathoadrenal system is only modestly diminished; however, the communication between the VMH and the alpha-cell is totally interrupted. (+info)
Deoxyglucose
... may refer to: 1,5-Anhydroglucitol (1-deoxyglucose) 2-Deoxy-D-glucose (2-deoxyglucose) This set index page lists ...
2-deoxyglucose-6-phosphatase
The enzyme 2-deoxyglucose-6-phosphatase (EC 3.1.3.68) catalyzes the reaction 2-deoxy-D-glucose 6-phosphate + H2O ⇌ {\ ... This enzyme is also called 2-deoxyglucose-6-phosphate phosphatase. Favello A; Fulton L; Gattung S; et al. (1994). "Complete ... two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed". Yeast. 11 (13): 1233-1240. ...
DTDP-4-dehydro-6-deoxyglucose reductase
In enzymology, a dTDP-4-dehydro-6-deoxyglucose reductase (EC 1.1.1.266) is an enzyme that catalyzes the chemical reaction dTDP- ... This enzyme is also called dTDP-4-keto-6-deoxyglucose reductase. This enzyme participates in polyketide sugar unit biosynthesis ...
CDP-4-dehydro-6-deoxyglucose reductase
... (EC 1.17.1.1) is an enzyme that catalyzes the chemical reaction CDP-4-dehydro-3,6- ... Other names in common use include CDP-4-keto-6-deoxyglucose reductase, cytidine diphospho-4-keto-6-deoxy-D-glucose reductase, ... cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase, CDP-4-keto-deoxy-glucose reductase, CDP-4-keto-6-deoxy-D-glucose ...
2-deoxy-D-gluconate 3-dehydrogenase
Eichhorn MM, Cynkin MA (January 1965). "Microbial metabolism of 2-deoxyglucose; 2-deoxyglucose acid dehydrogenase". ...
Herman S. Bachelard
Bachelard, HS (May 1972). "Deoxyglucose and brain glycolysis". The Biochemical Journal. 127 (5): 83P. doi:10.1042/bj1270083pa. ...
UDP-glucose 6-dehydrogenase
"Uridine diphosphate 2-deoxyglucose. Chemical synthesis, enzymic oxidation and epimerization". Biochimica et Biophysica Acta. ...
Para-Chloroamphetamine
A 2-deoxyglucose study in rats". Neuropsychopharmacology. 13 (3): 215-22. doi:10.1016/0893-133X(95)00053-G. PMID 8602894. Lin ...
Dopamine hypothesis of stuttering
... deoxyglucose study of developmental stuttering". NeuroReport. 6 (3): 501-505. doi:10.1097/00001756-199502000-00024. PMID ...
Thomas Kilduff
Kilduff TS, Miller JD, Radeke CM, Sharp FR, Heller HC (1990). "14C-2-deoxyglucose uptake in the ground squirrel brain during ... Kilduff TS, Sharp FR, Heller HC (1982). "[14C]2-deoxyglucose uptake in ground squirrel brain during hibernation". Neuroscience ...
Bilikere Dwarakanath
"B S Dwarakanath's Research on Deoxyglucose (2 Deoxy D glucose) , CureHunter". www.curehunter.com. Retrieved 23 July 2020. " ...
William J. Schwartz
Glucose consumption was studied via a technique using 14C-deoxyglucose (DG). DG is transported into the brain via the same ... Schwartz WJ, Gainer H. "Suprachiasmatic nucleus: use of 14C-labeled deoxyglucose uptake as a functional marker." Science. 1977 ... Schwartz demonstrated that the suprachiasmatic nucleus is rhythmic in vivo using a 2-deoxyglucose radioactive marker for ... mechanism which transports glucose, where it is then phosphorylated by hexokinase into 14C-deoxyglucose-6-phosphate(DG-6-P). ...
Caloric restriction mimetic
2-Deoxyglucose was the first agent pursued as a possible CRM. This compound inhibits glycolysis, and can mimic some of the ...
2-Deoxy-D-glucose
Wick, AN; Drury, DR; Nakada, HI; Wolfe, JB (1957). "Localization of the primary metabolic block produced by 2-deoxyglucose" ( ... Laussel, Clotilde; Léon, Sébastien (December 2020). "Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated ... 2-Deoxyglucose labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where ... "Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models". Analytical ...
Electronic fluency device
1995). "A positron emission tomography [18F]deoxyglucose study of developmental stuttering". NeuroReport. 6 (3): 501-5. doi: ...
Retronasal smell
2-deoxyglucose (2DG) is a radioactive glucose isotope that can be tracked in the brain since it leaves a trace in the cell ... This method is not terminal as is the 2-deoxyglucose method, so one animal can be measured with many odors, and the resulted ... "Functional organization of rat olfactory bulb analysed by the 2-deoxyglucose method". The Journal of Comparative Neurology. 185 ...
Radiopharmacology
An example is fludeoxyglucose in which fluorine-18 is incorporated into deoxyglucose. Some radioisotopes (for example gallium- ...
Society for Research on Biological Rhythms
Schwartz WJ, Gainer H (1977). "Suprachiasmatic nucleus: use of 14C-labeled deoxyglucose uptake as a functional marker". Science ... 2-deoxyglucose Paul Taghert: discovery of PDF's function as a coupling factor in the Drosophila clock Joseph Takahashi: ...
Cortical column
"Orientation columns in macaque monkey visual cortex demonstrated by the 2-deoxyglucose autoradiographic technique". Nature. 269 ...
UDP-sulfoquinovose synthase
The systematic name of this enzyme class is UDP-6-sulfo-6-deoxyglucose sulfohydrolase. Other names in common use include ...
Unfolded protein response
A23187 upregulates expression of ER stress proteins 2-deoxyglucose dithiothreitol reduces the disulfide bridges of proteins. ...
SLC2A9
... stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthr. Cartil. 11 (2 ...
Metastasectomy
Wiering B, Krabbe PF, Jager GJ, Oyen WJ, Ruers TJ (December 2005). "The impact of fluor-18-deoxyglucose-positron emission ...
SLC2A6
... stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthritis and ...
SLC2A10
... stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthr. Cartil. 11 (2 ...
Molecular imaging
"Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models". Anal. ...
1,5-Anhydroglucitol
Yoshioka S, Saitoh S, Negishi C, Fujisawa T, Takatani O, Imura M, Funagashi M (1983). "Variations of 1-deoxyglucose (1,5- ...
Hypothalamus
Food intake is rapidly increased by intraventricular administration of 2-deoxyglucose therefore decreasing glucose utilization ...
Fluorodeoxyglucose (18F)
... giving the protected fluorinated deoxyglucose (3). Base hydrolysis removes the acetyl protecting groups, giving the desired ...
Acadesine
August 2007). "5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake ...
Evidencing leprosy neuronal inflammation by 18-Fluoro-deoxy-glucose. | PLoS Negl Trop Dis;17(6): e0011383, 2023 Jun. |...
Low-dose 2-Deoxy Glucose Stabilises Tolerogenic Dendritic Cells and Generates Potent in vivo Immunosuppressive Effects<...
Christofi, M., Le Sommer, S., Moelzer, C., Klaska, I. P., Kuffova, L., & Forrester, J. V. (2021). Low-dose 2-Deoxy Glucose ... Low-dose 2-Deoxy Glucose Stabilises Tolerogenic Dendritic Cells and Generates Potent in vivo Immunosuppressive Effects. In: ... Low-dose 2-Deoxy Glucose Stabilises Tolerogenic Dendritic Cells and Generates Potent in vivo Immunosuppressive Effects. ... Low-dose 2-Deoxy Glucose Stabilises Tolerogenic Dendritic Cells and Generates Potent in vivo Immunosuppressive Effects. / ...
Citric acid production by 2-deoxyglucose-resistant mutant strains of Aspergillus niger<...
Kirimura K, Sarangbin S, Rugsaseel S, Usami S. Citric acid production by 2-deoxyglucose-resistant mutant strains of Aspergillus ... Kirimura, K, Sarangbin, S, Rugsaseel, S & Usami, S 1992, Citric acid production by 2-deoxyglucose-resistant mutant strains of ... Citric acid production by 2-deoxyglucose-resistant mutant strains of Aspergillus niger. / Kirimura, Kohtaro; Sarangbin, Somsak ... Kirimura, K., Sarangbin, S., Rugsaseel, S., & Usami, S. (1992). Citric acid production by 2-deoxyglucose-resistant mutant ...
ATSDR - Asbestos Expert Panel - Premeeting Comments
Targeting immunometabolism as an anti-inflammatory strategy | Cell Research
Often used as a non-invasive diagnostic tool, [18F]-fluoro-deoxyglucose positron-emission-tomography (FDG-PET) is therefore ... Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies. ... Glut-1 glucose transporter-1, 2-DG 2-deoxyglucose, SLE systemic lupus erythematosus, RA rheumatoid arthritis, GAPDH ...
Medical Aspects of Stuttering | Stuttering Foundation: A Nonprofit Organization Helping Those Who Stutter
Gastric Cancer Imaging: Practice Essentials, Radiography, Computed Tomography
Biomarkers Breast | European Society of Radiology
Longitudinal SPECT study in Alzheimer's disease: relation to apolipoprotein E polymorphism | Journal of Neurology, Neurosurgery...
Connection | Profiles RNS
mediaTUM - Media and Publication Server
Sensors | Free Full-Text | Polarographic Electrode Measures of Cerebral Tissue Oxygenation: Implications for Functional Brain...
Ocular Lymphoma: ACRONYMS, Overview, Epidemiology
Changes in Exercise-Induced Gene Expression in 5′-AMP-Activated Protein Kinase γ3-Null and γ3 R225Q Transgenic Mice | Diabetes ...
JCI -
Volume 93, Issue 3
Plus it
Diagnosis of Bartonella henselae Prosthetic Valve Endocarditis in Man, France - Volume 20, Number 8-August 2014 - Emerging...
Project Investigators - University of Mississippi Medical Center
Olfactory Bulb Glomeruli: External Tufted Cells Intrinsically Burst at Theta Frequency and Are Entrained by Patterned Olfactory...
Glucosamina: MedlinePlus suplementos
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride...
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes | Journal of...
Jurkat cells were unstimulated or treated with 10 μg/ml of the CD3 antibody UCHT1 or 50 mM 2-deoxyglucose for 1 and 5 min. The ... Jurkat cells were unstimulated or treated with 10 μg/ml of the CD3 antibody UCHT1 or 50 mM 2-deoxyglucose for 1 and 5 min. The ... F) 2-deoxyglucose-induced AMPK Thr-172 phosphorylation is resistant to STO-609. Untreated and STO-609-pretreated Jurkat cells ... F) 2-deoxyglucose-induced AMPK Thr-172 phosphorylation is resistant to STO-609. Untreated and STO-609-pretreated Jurkat cells ...
DeCS
Deoxyglucose Entry term(s). 2 Deoxy D glucose 2 Deoxyglucose 2 Desoxy D glucose 2-Deoxy-D-glucose 2-Deoxyglucose 2-Desoxy-D- ... 2 Deoxyglucose. 2 Desoxy D glucose. 2-Deoxy-D-glucose. 2-Deoxyglucose. 2-Desoxy-D-glucose. ... Deoxyglucose - Preferred Concept UI. M0006004. Scope note. 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with ... use GLUCOSE to search DEOXYGLUCOSE 1973-74 & use HEXOSES 1967-72. History Note:. 91(75); was see under DEOXY SUGARS 1975-90; ...
Search Results For Health And Wellness: them Results found: 1409
OPUS Würzburg | Funktionelle Untersuchung zur Duplikation des SLC2A3-Gens in Patienten mit Aufmerksamkeitsdefizit-...
... cellular glucose uptake was measured using radiolabeled 2-deoxyglucose in lymphoblastoid cell lines (EBV-LCLs) immortalized via ... cellular glucose uptake was measured using radiolabeled 2-deoxyglucose in lymphoblastoid cell lines (EBV-LCLs) immortalized via ... cellular glucose uptake was measured using radiolabeled 2-deoxyglucose in lymphoblastoid cell lines (EBV-LCLs) immortalized via ...
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous...
2-deoxyglucose (2-DG) and its fluorinated derivative decreased glycolytic and Krebs cycle activity, cellular energy, and ... 2-deoxyglucose (2-DG) and its fluorinated derivative decreased glycolytic and Krebs cycle activity, cellular energy, and ... 2-deoxyglucose (2-DG) and its fluorinated derivative decreased glycolytic and Krebs cycle activity, cellular energy, and ... 2-deoxyglucose (2-DG) and its fluorinated derivative decreased glycolytic and Krebs cycle activity, cellular energy, and ...
PEPSIC - pepsic.bvsalud.org
Impact of 18F-FDG PET/CT with Retrograde Filling of the Urinary Bladder in Patients with Suspected Pelvic Malignancies |...
Glucose4
- In the late 1950s, other researchers had discovered a glucose analog, 2-deoxyglucose (2-DG), which behaves just like glucose in the first step of the ten-step metabolic pathway of glycolysis. (nih.gov)
- It had been shown that in the brain two molecules of glucose are normally converted into glucose-6-phosphate for every molecule of 2-deoxyglucose converted to 2-DG-6-phosphate. (nih.gov)
- This deoxyglucose method was developed by Dr. Sokoloff in order to measure regional glucose metabolism. (nih.gov)
- For this purpose, cellular glucose uptake was measured using radiolabeled 2-deoxyglucose in lymphoblastoid cell lines (EBV-LCLs) immortalized via Eppstein-Barr virus. (uni-wuerzburg.de)
Derivative2
- Sokoloff provided a review of his lab's deoxyglucose work so far: the theory and properties of the [14C] deoxyglucose and its derivative [18F] fluorodeoxyglucose methods, and their applications to many physiological, pharmacological, and pathological conditions. (nih.gov)
- 2-deoxyglucose (2-DG) and its fluorinated derivative decreased glycolytic and Krebs cycle activity, cellular energy, and reducing potential and inhibited HNSCC cell proliferation. (elsevier.com)
Method1
- They were inventing something called the deoxyglucose method. (nih.gov)