Glucose
Antimetabolites
Monosaccharide Transport Proteins
Autoradiography
Fluorodeoxyglucose F18
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
Glycolysis
A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.
3-O-Methylglucose
Biological Transport
Hexokinase
An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.
Carbon Radioisotopes
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Glucose-6-Phosphate
Glucose Transporter Type 1
Glucose Transporter Type 4
A glucose transport protein found in mature MUSCLE CELLS and ADIPOCYTES. It promotes transport of glucose from the BLOOD into target TISSUES. The inactive form of the protein is localized in CYTOPLASMIC VESICLES. In response to INSULIN, it is translocated to the PLASMA MEMBRANE where it facilitates glucose uptake.
Tomography, Emission-Computed
Biological Transport, Active
Fluorine Radioisotopes
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Radiopharmaceuticals
Adenosine Triphosphate
Mannose
Tolazamide
Phosphoenolpyruvate Sugar Phosphotransferase System
The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.
Receptor, Insulin
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
Muscle, Skeletal
Sodium Azide
4-Chloro-7-nitrobenzofurazan
Rats, Inbred Strains
Positron-Emission Tomography
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Fructose
Muscle Proteins
Glucokinase
Galactose
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
Iodoacetates
Antimycin A
Energy Metabolism
Thiogalactosides
Adipocytes
Rats, Sprague-Dawley
Cells, Cultured
Adipose Tissue
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Phosphorylation
Cyanides
Glucose Transport Proteins, Facilitative
Lactic Acid
Myocardium
Carbohydrate Metabolism
Cell Membrane
Rats, Wistar
Oligomycins
A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).
Aminoimidazole Carboxamide
Iodoacetic Acid
2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages II. Dissociation of the inhibitory effects of 2-deoxyglucose on phagocytosis and ATP generation. (1/2660)
Macrophages incubated in 2-deoxy-D-glucose (2-dG)-containing medium showed a marked decrease in cellular ATP content, and were unable to ingest IgG- and complement-coated erythrocytes via the corresponding membrane receptors for these ligands. However, the inhibitory effects of 2-dG on Fc- and C3 receptor-mediated phagocytosis were not a consequence of lowered macrophage ATP levels since addition of glucose or mannose to the culture medium restored the capacity of the macrophages to ingest IgG- and C3-coated particles without increasing ATP levels. These results indicate that Fc- and C3 receptor-mediated phagocytosis (opsonin dependent) differs qualitatively from the ingestion of latex and zymosan particles (opsonin independent); they suggest that the same regulatory molecules govern the responses of phagocytic cells to signals initiated by both the Fc and C3 receptors. The possibility that these molecules are regulated by glycosylation is discussed. (+info)The biological clock of very premature primate infants is responsive to light. (2/2660)
Each year more than 250,000 infants in the United States are exposed to artificial lighting in hospital nurseries with little consideration given to environmental lighting cycles. Essential in determining whether environmental lighting cycles need to be considered in hospital nurseries is identifying when the infant's endogenous circadian clock becomes responsive to light. Using a non-human primate model of the developing human, we examined when the circadian clock, located in the hypothalamic suprachiasmatic nuclei (SCN), becomes responsive to light. Preterm infant baboons of different ages were exposed to light (5,000 lux) at night, and then changes in SCN metabolic activity and gene expression were assessed. After exposure to bright light at night, robust increases in SCN metabolic activity and gene expression were seen at ages that were equivalent to human infants at 24 weeks after conception. These data provide direct evidence that the biological clock of very premature primate infants is responsive to light. (+info)Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. (3/2660)
Platelets express leukotriene (LT) C4 synthase and can thus participate in the formation of bioactive LTC4. To further elucidate the relevance of this capability, we have now determined the capacity of human platelets to export LTC4. Endogenously formed LTC4 was efficiently released from human platelets after incubation with LTA4 at 37 degrees C, whereas only 15% of produced LTC4 was exported when the cells were incubated at 0 degrees C. The activation energy of the process was calculated to 49.9 +/- 7.7 kJ/mol, indicating carrier-mediated LTC4 export. This was also supported by the finding that the transport was saturable, reaching a maximal export rate of 470 +/- 147 pmol LTC4/min x 10(9) platelets. Furthermore, markedly suppressed LTC4 transport was induced by a combination of the metabolic inhibitors antimycin A and 2-deoxyglucose, suggesting energy-dependent export. The presence in platelets of multidrug resistance-associated protein 1 (MRP1), a protein described to be an energy-dependent LTC4 transporter in various cell types, was demonstrated at the mRNA and protein level. Additional support for a role of MRP1 in platelet LTC4 export was obtained by the findings that the process was inhibited by probenecid and the 5-lipoxygenase-activating protein (FLAP) inhibitor, MK-886. The present findings further support the physiological relevance of platelet LTC4 production. (+info)Mannose inhibits Arabidopsis germination via a hexokinase-mediated step. (4/2660)
Low concentrations of the glucose (Glc) analog mannose (Man) inhibit germination of Arabidopsis seeds. Man is phosphorylated by hexokinase (HXK), but the absence of germination was not due to ATP or phosphate depletion. The addition of metabolizable sugars reversed the Man-mediated inhibition of germination. Carbohydrate-mediated regulation of gene expression involving a HXK-mediated pathway is known to be activated by Glc, Man, and other monosaccharides. Therefore, we investigated whether Man blocks germination through this system. By testing other Glc analogs, we found that 2-deoxyglucose, which, like Man, is phosphorylated by HXK, also blocked germination; no inhibition was observed with 6-deoxyglucose or 3-O-methylglucose, which are not substrates for HXK. Since these latter two sugars are taken up at a rate similar to that of Man, uptake is unlikely to be involved in the inhibition of germination. Furthermore, we show that mannoheptulose, a specific HXK inhibitor, restores germination of seeds grown in the presence of Man. We conclude that HXK is involved in the Man-mediated repression of germination of Arabidopsis seeds, possibly via energy depletion. (+info)Developmental regulation of genes mediating murine brain glucose uptake. (5/2660)
We examined the molecular mechanisms that mediate the developmental increase in murine whole brain 2-deoxyglucose uptake. Northern and Western blot analyses revealed an age-dependent increase in brain GLUT-1 (endothelial cell and glial) and GLUT-3 (neuronal) membrane-spanning facilitative glucose transporter mRNA and protein concentrations. Nuclear run-on experiments revealed that these developmental changes in GLUT-1 and -3 were regulated posttranscriptionally. In contrast, the mRNA and protein levels of the mitochondrially bound glucose phosphorylating hexokinase I enzyme were unaltered. However, hexokinase I enzyme activity increased in an age-dependent manner suggestive of a posttranslational modification that is necessary for enzymatic activation. Together, the postnatal increase in GLUT-1 and -3 concentrations and hexokinase I enzymatic activity led to a parallel increase in murine brain 2-deoxyglucose uptake. Whereas the molecular mechanisms regulating the increase in the three different gene products may vary, the age-dependent increase of all three constituents appears essential for meeting the increasing demand of the maturing brain to fuel the processes of cellular growth, differentiation, and neurotransmission. (+info)Endothelin stimulates glucose uptake and GLUT4 translocation via activation of endothelin ETA receptor in 3T3-L1 adipocytes. (6/2660)
Endothelin-1 (ET-1) is a 21-amino acid peptide that binds to G-protein-coupled receptors to evoke biological responses. This report studies the effect of ET-1 on regulating glucose transport in 3T3-L1 adipocytes. ET-1, but not angiotensin II, stimulated glucose uptake in a dose-dependent manner with an EC50 value of 0.29 nM and a 2.47-fold stimulation at 100 nM. ET-1 stimulated glucose uptake in differentiated 3T3-L1 cells but had no effect in undifferentiated cells, although ET-1 stimulated phosphatidylinositol hydrolysis to a similar degree in both. The 3T3-L1 cells expressed approximately 560,000 sites/cell of ETA receptor, which was not altered during differentiation. Western blot analysis and immunofluorescence staining show that ET-1 stimulated the translocation of insulin-responsive aminopeptidase and GLUT4 to the plasma membrane. The effect of ET-1 on glucose uptake was blocked by A-216546, an antagonist selective for the ETA receptor. ET-1 treatment did not induce phosphorylation of insulin receptor beta-subunit, insulin receptor substrate-1, or Akt but stimulated the tyrosyl phosphorylation of a 75-kDa protein. Genistein (100 microM), an inhibitor of tyrosine kinases, inhibited ET-1-stimulated glucose uptake. Our results show that ET-1 stimulates GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes via activation of ETA receptor. (+info)High concentration of glucose decreases glucose transporter-1 expression in mouse placenta in vitro and in vivo. (7/2660)
Facilitative glucose transporter-1 (GLUT1) is expressed abundantly and has an important role in glucose transfer in placentas. However, little is known about the regulation of GLUT1 expression in placental cells. We studied the changes in placental GLUT1 levels in relation to changes in glucose concentration in vitro and in vivo. In in vitro experiments, dispersed mouse placental cells were incubated under control (5.5 mM) and moderately high (22 mM) glucose concentrations, and 2-deoxyglucose uptake into cells was studied on days 1-5 of culture. After 4 days of incubation under both conditions, GLUT1 mRNA and proten levels were examined by Northern and immunoblot analyses. Treatment of cells with 22 mM glucose resulted in a significant decrease in 2-deoxyglucose uptake compared with control, from day 2 to day 5 of culture. Moreover, GLUT1 mRNA and protein levels on day 4 of culture were significantly reduced in cells incubated with 22 mM glucose compared with control. Next, we rendered mice diabetic by administering 200 micrograms/g body weight streptozotocin (STZ) on day 8 of pregnancy. Animals were killed on day 12 of pregnancy and placental tissues were obtained. [3H]Cytochalasin B binding study was carried out to assess total GLUTs, and GLUT1 mRNA and protein were measured as above. [3H]Cytochalasin B binding sites in placentas from STZ-treated mice were significantly less than those in control mice. Northern and immunoblot analyses revealed a significant decrease in GLUT1 mRNA and protein levels in diabetic mice compared with the controls. These findings suggest that the glucose concentration may regulate the expression of placental GLUT1. (+info)Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats. (8/2660)
Previous studies have demonstrated that the ventromedial hypothalamus (VMH) plays a critical role in sensing and responding to systemic hypoglycemia. To evaluate the mechanisms of defective counterregulation caused by iatrogenic hypoglycemia and diabetes per se, we delivered 2-deoxy-glucose (2-DG) via microdialysis into the VMH to produce localized cellular glucopenia in the absence of systemic hypoglycemia. Three groups of awake chronically catheterized rats were studied: 1) nondiabetic (with a mean daily glucose [MDG] of 6.9 mmol/l) BB control rats (n = 5); 2) chronically hypoglycemic nondiabetic (3-4 weeks, with an MDG of 2.7 mmol/l) BB rats (n = 5); and 3) moderately hyperglycemic insulin-treated diabetic (with an MDG of 12.4 mmol/l) BB rats (n = 8). In hypoglycemic rats, both glucagon and catecholamine responses to VMH glucopenia were markedly (77-93%) suppressed. In diabetic rats, VMH 2-DG perfusion was totally ineffective in stimulating glucagon release. The epinephrine response, but not the norepinephrine response, was also diminished by 38% in the diabetic group. We conclude that impaired counterregulation after chronic hypoglycemia may result from alterations of the VMH or its efferent pathways. In diabetes, the capacity of VMH glucopenia to activate the sympathoadrenal system is only modestly diminished; however, the communication between the VMH and the alpha-cell is totally interrupted. (+info)
The [14C]Deoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization: Theory, Procedure, and Normal Values
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Cerebral glucose utilization is reduced in second test session<...
Ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices: Protection by 5-HT<sub...
Evaluation and Comparison of Various Strategies for Estimating Local Cerebral Glucose Metabolic Rate from Brain Images in...
Cerebral glucose utilization in polysubstance abuse. - PubMed - NCBI
Plus it
Altmetric - Basic, Clinical, and Therapeutic Aspects of Alzheimers and Parkinsons Diseases
Publications - Lampidis Cancer Foundation
In vivo determination of transport and metabolism of deoxyglucose in intestinal tissues | SpringerLink
ARIC Publications
Effect of age and high sucrose diet on 2-deoxyglucose uptake in perfused hindlimb<...
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Greiner Vacuette Glycolytic Inhibitor 4 ml - 454297
Serum 1,5-Anhydroglucitol: Risk Factor of Acute Ischemic Stroke and Transient Ischemic Attack in Well-Controlled Diabetes
Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and rn by J Rosen, J Fina et al.
Hyperpermeability and ATP depletion induced by chronic hypoxia or glycolytic inhibition in Caco-2BBe monolayers - Fingerprint
...
Plus it
Glycolysis Inhibitors
SV40 Virus Transformation of Mouse 3T3 Cells Does Not Specifically Enhance Sugar Transport | Science
2-Deoxy-d-glucose - Alfa Chemistry
2-[2-13c]Acetamido-2-Deoxy-d-glucose - Alfa Chemistry
2-Deoxy-D-glucose | Phion
Structure Summary for 2O8F
Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. | Hypertension
Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. | Stroke
Transport and phosphorylation of 2-deoxy-D-glucose by amphibian retina. Effects of light and darkness. | JGP
18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer ...
Serum glucose: Effects on tumor and normal tissue accumulation of 2-[F-18]-fluoro-2-deoxy-D-glucose in rodents with mammary...
Plus it
The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells | BMC Cancer | Full...
Variety and complexity of fluorine-18-labelled fluoro-2-deoxy-D-glucose accumulations in the oral cavity of patients with oral...
Deoxy-D-glucose, 2-[14C(U)]-, Specific Activity: 250-350mCi (9.25-13.0GBq)/mmol, 250µCi (9.25MBq) | PerkinElmer
Deoxy-D-glucose, 2-[14C(U)]-, Specific Activity: 250-350mCi (9.25-13.0GBq)/mmol, 250µCi (9.25MBq) | PerkinElmer
Background Improved glycolysis is definitely a hallmark of cancer metabolism, yet | immune-source.com
Serials - Metabolism of 2-deoxy-D-glucose by Bakers yeast | Collection of Czechoslovak Chemical Communications
2-amino-2-deoxy-D-[1, 2-13C2]glucose HCl (D-[1, 2-13C2]glucosamine hydrochloride) - Creative Proteomics
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Plus it
DGCI has granted permission for emergency use of 2-deoxy-D-glucose - News Nation English
6wtaw142gfasaml2mt2dg4lbltymk-keyword ideas generator
pathological hypercaptation of the lingula | Case Studies
Search Articles | University of Toronto Libraries
Features of Regional Cerebral Glucose Metabolism Abnormality in Corticobasal Degeneration - Abstract - Dementia and Geriatric...
Regional cerebral glucose metabolism during and after bilateral cerebral ischemia in the gerbil. | Stroke
Fluorescent glucose biosensor - Wikipedia
4-Deoxy-4-fluoro-D-glucose 29218-07-3 MSDS, Safety Technical Specifications MSDS
Habenula - Scholarpedia
Tritiated 2‐deoxy‐D‐glucose: A high‐resolution marker for autoradiographic localization of brain metabolism<...
2-Deoxy-glucose Enhances the Effect of Cisplatin and Pemetrexed in Reducing Malignant Pleural Mesothelioma Cell Proliferation...
ORBi: Browsing ORBi
Peters Blog: January 2011
Experimental study for cancer diagnosis with positron-labeled fluorinated glucose analogs: [<sup>18</sup>F]-2-fluoro-2-deoxy-D...
Determination of the deoxyglucose and glucose phosphorylation ratio and the lumped constant in rat brain and a transplantable...
Initial experience with continuous intra-arterial fluorescent glucose monitoring in patients in the ICU following cardiac...
Metabolic control of resistance of human epithelial cells to H2O2 and NO stresses | Biochemical Journal | Portland Press
what does glycolysis produce
Sarcomas represent a diverse group of malignancies with distinct pathological and
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Pi Chemicals System - PI-15720 2-Deoxy-D-glucose (154-17-6)
Cell count | Zellanalys to » Metabolism and Human T Cell Proliferation
Plus it
Glucose Archives - Focus Biomolecules
Abstract
65kwv10142gfasaml2mt2dg4lblt91gu-keyword ideas generator
Energy metabolism and t-cell-mediated cytolysis. II. Selective inhib by H R. Macdonald
SAUSA300 0820 - AureoWiki
2-Deoxy-2-Phthalimido-tri-acetofluoro-alpha-D-glucose › PeptaNova
Structure Summary for 2FMP
2-deoxy-D-gluconate 3-dehydrogenase
Eichhorn MM, Cynkin MA (January 1965). "Microbial metabolism of 2-deoxyglucose; 2-deoxyglucose acid dehydrogenase". ...
Herman S. Bachelard
Bachelard, HS (May 1972). "Deoxyglucose and brain glycolysis". The Biochemical Journal. 127 (5): 83P. doi:10.1042/bj1270083pa. ...
UDP-glucose 6-dehydrogenase
"Uridine diphosphate 2-deoxyglucose. Chemical synthesis, enzymic oxidation and epimerization". Biochimica et Biophysica Acta. ...
Para-Chloroamphetamine
A 2-deoxyglucose study in rats". Neuropsychopharmacology. 13 (3): 215-22. doi:10.1016/0893-133X(95)00053-G. PMID 8602894. Lin ...
Dopamine hypothesis of stuttering
... deoxyglucose study of developmental stuttering". NeuroReport. 6 (3). Blomgren, Michael; Nagarajan, Srikantan S.; Lee, James N ...
Thomas Kilduff
Kilduff TS, Miller JD, Radeke CM, Sharp FR, Heller HC (1990). "14C-2-deoxyglucose uptake in the ground squirrel brain during ... Kilduff TS, Sharp FR, Heller HC (1982). "[14C]2-deoxyglucose uptake in ground squirrel brain during hibernation". Neuroscience ...
Bilikere Dwarakanath
"B S Dwarakanath's Research on Deoxyglucose (2 Deoxy D glucose) , CureHunter". www.curehunter.com. Retrieved 23 July 2020. " ...
2-Deoxy-D-glucose
2-Deoxyglucose has been proposed by Garriga-Canut et al. as a mimic for the ketogenic diet, and shows great promise as a new ... glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate intracellularly (with ... 2-Deoxyglucose labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where ... Wick, AN; Drury, DR; Nakada, HI; Wolfe, JB (1957). "Localization of the primary metabolic block produced by 2-deoxyglucose" ( ...
William J. Schwartz
Glucose consumption was studied via a technique using 14C-deoxyglucose (DG). DG is transported into the brain via the same ... Schwartz WJ, Gainer H. "Suprachiasmatic nucleus: use of 14C-labeled deoxyglucose uptake as a functional marker." Science. 1977 ... Schwartz demonstrated that the suprachiasmatic nucleus is rhythmic in vivo using a 2-deoxyglucose radioactive marker for ... mechanism which transports glucose, where it is then phosphorylated by hexokinase into 14C-deoxyglucose-6-phosphate(DG-6-P). ...
Caloric restriction mimetic
2-Deoxyglucose was the first agent pursued as a possible CRM. This compound inhibits glycolysis, and can mimic some of the ...
Electronic fluency device
1995). "A positron emission tomography [18F]deoxyglucose study of developmental stuttering". NeuroReport. 6 (3): 501-5. doi: ...
Retronasal smell
2-deoxyglucose (2DG) is a radioactive glucose isotope that can be tracked in the brain since it leaves a trace in the cell ... This method is not terminal as is the 2-deoxyglucose method, so one animal can be measured with many odors, and the resulted ... "Functional organization of rat olfactory bulb analysed by the 2-deoxyglucose method". The Journal of Comparative Neurology. 185 ...
Radiopharmacology
An example is fludeoxyglucose in which fluorine-18 is incorporated into deoxyglucose. Some radioisotopes (for example gallium- ...
Society for Research on Biological Rhythms
Schwartz WJ, Gainer H (1977). "Suprachiasmatic nucleus: use of 14C-labeled deoxyglucose uptake as a functional marker". Science ... 2-deoxyglucose Paul Taghert: discovery of PDF's function as a coupling factor in the Drosophila clock Joseph Takahashi: ...
Cortical column
"Orientation columns in macaque monkey visual cortex demonstrated by the 2-deoxyglucose autoradiographic technique". Nature. 269 ...
UDP-sulfoquinovose synthase
The systematic name of this enzyme class is UDP-6-sulfo-6-deoxyglucose sulfohydrolase. Other names in common use include ...
Unfolded protein response
A23187 upregulates expression of ER stress proteins 2-deoxyglucose dithiothreitol reduces the disulfide bridges of proteins. ...
SLC2A9
... stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthr. Cartil. 11 (2 ...
Metastasectomy
Wiering B, Krabbe PF, Jager GJ, Oyen WJ, Ruers TJ (December 2005). "The impact of fluor-18-deoxyglucose-positron emission ...
SLC2A6
... stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthritis and ...
1,5-Anhydroglucitol
Yoshioka S, Saitoh S, Negishi C, Fujisawa T, Takatani O, Imura M, Funagashi M (1983). "Variations of 1-deoxyglucose (1,5- ...
Hypothalamus
Food intake is rapidly increased by intraventricular administration of 2-deoxyglucose therefore decreasing glucose utilization ...
HDHD1A
... induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose ...
Fluorodeoxyglucose (18F)
... giving the protected fluorinated deoxyglucose (3). Base hydrolysis removes the acetyl protecting groups, giving the desired ...
Acadesine
August 2007). "5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake ...
Behavioral neuroscience
Likewise, the injection of 2-deoxyglucose prior to some behavioral task can be followed by anatomical localization of that ...
Monolysocardiolipin acyltransferase
MLCL AT-1 activity increases in cells cardiac myoblast cells exposed to 2-deoxyglucose-induced apoptosis. MLCL AT-1 activity ... acyltransferase is elevated in the surviving population of H9c2 cardiac myoblast cells exposed to 2-deoxyglucose-induced ...
Fluorodeoxyglycosylamine
Reductive amination of hydrophilic 18F-fluoro-2-deoxyglucose with lipophilic amines for development of potential PET imaging ...
Orientation column
His technique used photodiodes to detect optical changes in the visual cortex with the metabolic marker, 2-deoxyglucose, which ...
Buformin
Yakisich JS, Azad N, Kaushik V, Iyer AK (2019). "The Biguanides Metformin and Buformin in Combination with 2-Deoxy-glucose or ...
Deoxyglucose - Wikipedia
2-deoxyglucose-6-phosphatase - Wikipedia
In enzymology, a 2-deoxyglucose-6-phosphatase (EC 3.1.3.68) is an enzyme that catalyzes the chemical reaction 2-deoxy-D-glucose ... This enzyme is also called 2-deoxyglucose-6-phosphate phosphatase. Favello A; Fulton L; Gattung S; et al. (1994). "Complete ... two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed". Yeast. 11 (13): 1233-1240. ...
In vivo determination of transport and metabolism of deoxyglucose in intestinal tissues | SpringerLink
Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettegrew KD, Sakurada O, Shinohara M (1977) The14C-deoxyglucose ... Wick AN, Drury DR, Nakada HI, Wolfe JB (1957) Localisation of the primary metabolic block produced by 2-deoxyglucose. J Biol ... In vivo determination of transport and metabolism of deoxyglucose in intestinal tissues. ... of14C labeled deoxy-glucose (DG) was determined. The method can also be used for estimating tissue glucose uptake. The rate ...
Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. | Hypertension
Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats.. M Bursztyn, I Raz, J Mekler, D Ben-Ishay ... Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats.. M Bursztyn, I Raz, J Mekler and D Ben- ... Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats.. M Bursztyn, I Raz, J Mekler and D Ben- ... Deoxyglucose plasma half-life and fasting and post-glucose load insulin levels were comparable in the two groups. The results ...
AuNP-DG: Deoxyglucose-Labeled Gold Nanoparticles as X-ray Computed Tomography Contrast Agents for Cancer Imaging | SpringerLink
Frontiers | 2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure Control | Cellular Neuroscience
2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure Control. Jong M. Rho1,2,3*, Li-Rong Shao4 and Carl E. ... 2-Deoxyglucose Versus/Plus Ketone Bodies. From the foregoing discussion, it is important to note both 2DG and the KD can ... 2-Deoxyglucose, A Glycolysis Inhibitor. As mentioned above, the KD mimics fasting in restricting the intake of the main source ... 2-Deoxyglucose (2DG), an inhibitor of glycolysis, abrogates seizure activity and retards epilepsy progression both in vitro and ...
Fluorinated deoxyglucose positron emission tomography imaging in progressive metastatic prostate cancer
PET for diagnosis of malignant lymphoma of the scalp: comparison of [11C]methyl-L-methionine and [18F]fluoro-2-deoxyglucose. -...
Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic...
Table 2 | [18F]-Fluoro-Deoxy-Glucose Positron Emission Tomography Scan Should Be Obtained Early in Cases of Autoimmune...
Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death | Cancer Research
Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death. Gang Cheng, Jacek Zielonka, ... Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. Int J Cancer 2008;123:476- ... Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death ... Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death ...
Stability of 18F-deoxyglucose uptake locations within tumor during radiotherapy for NSCLC: a prospective study
Correlation Between Various Adipokines and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro...
Foods | Free Full-Text | A 2-Deoxyglucose-Resistant Mutant of Saccharomyces cerevisiae Shows Enhanced Maltose Fermentative...
Saccharomyces cerevisiae MCD4 is a 2-deoxyglucose (2-DOG)-resistant mutant derived from the wild-type strain, AK46, wherein the ... A 2-Deoxyglucose-Resistant Mutant of Saccharomyces cerevisiae Shows Enhanced Maltose Fermentative Ability by the Activation of ... "A 2-Deoxyglucose-Resistant Mutant of Saccharomyces cerevisiae Shows Enhanced Maltose Fermentative Ability by the Activation of ... Saccharomyces cerevisiae MCD4 is a 2-deoxyglucose (2-DOG)-resistant mutant derived from the wild-type strain, AK46, wherein the ...
Sequence Similarity
- 1OFN: Purification, crystallisation and preliminary structural studies of dTDP-4-keto-6-deoxy...
Radiotherapy Planning Based on Positron Emission Tomography With Fluoro-deoxyglucose For Advanced NSCLC
Abstract C156: PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose. | Molecular Cancer Therapeutics
Abstract C156: PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose.. Sui-Seng Tee, Jae Mo Park and ... Introduction: This study proposes the use 2-deoxyglucose (2DG) with the PKM2 activator, TEPP46 as a novel drug combination for ... PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose. [abstract]. In: Proceedings of the AACR-NCI- ... Abstract C156: PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose. ...
Mutations That Confer Resistance to 2-Deoxyglucose Reduce the Specific Activity of Hexokinase from Myxococcus xanthus | Journal...
Mutations That Confer Resistance to 2-Deoxyglucose Reduce the Specific Activity of Hexokinase from Myxococcus xanthus Philip ... 1977) Resistance to 2-deoxyglucose in yeast: a direct selection of mutants lacking glucose-phosphorylating enzymes. Mol. Gen. ... M. xanthus is sensitive to the antibiotic 2-deoxyglucose (2dGlc). In most organisms, the analog 2dGlc is transported by ... The glucose analog 2-deoxyglucose (2dGlc) inhibits the growth and multicellular development of Myxococcus xanthus. Mutants ofM ...
5-Aminoimidazole-4-Carboxamide 1-β-d-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men |...
where 2DGU is deoxyglucose uptake, DG is the concentration of 2-deoxyglucose, DG6P is the concentration of 2-deoxyglucose 6- ... We studied 29 healthy men (aged 26 ± 8 years, BMI 25 ± 4 kg/m2 [mean ± SD]). Rates of muscle 2-deoxyglucose (2DG) uptake were ... To determine whether there was a linear increase in the muscle concentration of 2DG and 2-deoxyglucose 6-phosphate (2DG6P) ... Hansen PA, Gulve EA, Holloszy JO: Suitability of 2-deoxyglucose for in vitro measurement of glucose transport activity in ...
Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats | Endocrinology and...
Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats. K. Meszaros, G. J. Bagby ... Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats. K. Meszaros, G. J. Bagby ... The accumulation of phosphorylated 2-deoxyglucose (2DGP) was increased in skeletal muscles by 56-102% and in diaphragm by 236% ... Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats ...
2-Deoxyglucose Fluorometric Assay Kit Kit-0004 - Creative BioMart
2-Deoxyglucose Fluorometric Assay Kit can be used for research. ... 1 ml2-Deoxyglucose (2-DG, 10 mM). Cap code: purple. 1 ml2-DG ... Purified 2-Deoxyglucose Fluorometric Assay Kit from Creative Biomart. ... 2-Deoxyglucose Assay Kit (Fluorometric) is a quantitative fluorometric determination of 2-deoxyglucose.. ... 2-Deoxyglucose Fluorometric Assay Kit. Download Datasheet See All 2DG Related Kits Bring this labeled protein directly to your ...
2-amino-2-deoxyglucose sulfate | definition of 2-amino-2-deoxyglucose sulfate by Medical dictionary
2-amino-2-deoxyglucose sulfate explanation free. What is 2-amino-2-deoxyglucose sulfate? Meaning of 2-amino-2-deoxyglucose ... Looking for online definition of 2-amino-2-deoxyglucose sulfate in the Medical Dictionary? ... redirected from 2-amino-2-deoxyglucose sulfate). Also found in: Dictionary, Thesaurus, Encyclopedia. glucosamine. [gloo-ko´-sah ... n 2-amino-2-deoxyglucose in chitin, mucopolysaccharides, and mucoproteins. Used with chondroitin for osteoarthritis. Not for ...
The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2...
An evolutionarily conserved family of phosphatases enables cells to resist the toxic metabolic effects of 2-deoxyglucose. ... An evolutionarily conserved family of phosphatases enables cells to resist the toxic metabolic effects of 2-deoxyglucose. ... induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose ... induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose ...
A nonradioisotope, enzymatic assay for 2-deoxyglucose uptake in L6 skeletal muscle cells cultured in a 96-well microplate. |...
Legionella pneumophila Is Directly Sensitive to 2-Deoxyglucose-Phosphate via Its UhpC Transporter but Is Indifferent to Shifts...
Treatment with 2-deoxyglucose (2DG) blocks L. pneumophila replication in mammalian macrophages but has no effect on bacteria ... Legionella pneumophila Is Directly Sensitive to 2-Deoxyglucose-Phosphate via Its UhpC Transporter but Is Indifferent to Shifts ... Legionella pneumophila is directly sensitive to 2-deoxyglucose-phosphate via its UhpC transporter but is indifferent to shifts ... Legionella pneumophila Is Directly Sensitive to 2-Deoxyglucose-Phosphate via Its UhpC Transporter but Is Indifferent to Shifts ...
The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2...
The expression of a specific 2-deoxyglucose-6P phosphatase prevents catabolite repression mediated by 2-deoxyglucose in yeast. ... 2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 78, 1392-1399 (2006 ... Effect of 2-deoxyglucose on cell wall formation in Saccharomyces cerevisiae and its relation to cell growth inhibition. J. ... Lysis of yeast cell walls induced by 2-deoxyglucose at their sites of glucan synthesis. J. Bacteriol. 95, 1169-1172 (1968).. ...
Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. | Stroke
Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat.. D J ... Because 2-deoxyglucose (2-DG) is a competitive inhibitor of glycolysis we tested its ability to reduce hyperglycemia- ... Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. ... Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. ...
Plus it
2-Deoxy-glucose (2DG), a mimetic of glucose cannot undergo further glycolysis and hampers cell growth, essential during tumor ... 2-Deoxy-glucose synergizes with Cisplatin and Pemetrexed chemotherapeutics to reduce cell migration of mesothelioma cells. ... 2-Deoxy-glucose synergizes with Cisplatin and Pemetrexed chemotherapeutics to reduce cell migration of mesothelioma cells ... 2-Deoxy-glucose synergizes with Cisplatin and Pemetrexed chemotherapeutics to reduce cell migration of mesothelioma cells ...
Enzymatic Conversion of Glucose to UDP-4-Keto-6-Deoxyglucose in Streptomyces spp | Applied and Environmental Microbiology
Enzymatic Conversion of Glucose to UDP-4-Keto-6-Deoxyglucose in Streptomyces spp. Song Yu Liu, John P. N. Rosazza ... Enzymatic Conversion of Glucose to UDP-4-Keto-6-Deoxyglucose in Streptomyces spp ... Enzymatic Conversion of Glucose to UDP-4-Keto-6-Deoxyglucose in Streptomyces spp ... Enzymatic Conversion of Glucose to UDP-4-Keto-6-Deoxyglucose in Streptomyces spp ...
UptakePositronGlycolysisFluoro-2-deoxyglucoseInhibition by 2-deoxyglucosePhosphorylationAccumulationTumor cellsGlycolytic inhibitorRatsAnalogHexokinaseVitroPhosphataseAutoradiographyAbstractGrowth inhibitionMetabolismMetabolicSaccharomycesQuantitativeFermentationCellsNeuronsEmissionAssayMutantsInhibitoryRabbitsTherapeuticInsulinAcetateAminoYeastEffectsMacrophagesCancer
Uptake29
- Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. (ahajournals.org)
- 03). Glucose utilization was estimated by the uptake of [3H]deoxyglucose after its intravenous administration (2 microCi/100 g body wt) to instrumented awake animals. (ahajournals.org)
- To correlate the abnormalities on computed tomography, magnetic resonance imaging, and bone scan with fluorinated deoxyglucose positron emission tomography (FDG-PET) in patients with progressive metastatic prostate cancer, using a lesion-by-lesion analysis, and to preliminarily explore post-treatment changes in standard uptake value (SUV) with changes in prostate-specific antigen (PSA). (nih.gov)
- Because individual tumors are heterogeneous, including for (18)F-deoxyglucose (FDG) uptake and, most likely, for radioresistance, selective boosting of high FDG uptake zones within the tumor has been suggested. (nih.gov)
- Rates of muscle 2-deoxyglucose (2DG) uptake were determined by measuring accumulation of total muscle 2DG (2DG and 2DG-6-phosphate) during a primed, continuous 2DG infusion. (diabetesjournals.org)
- In rat muscle AICAR increases 2-deoxyglucose (2DG) uptake because of an effect on transport rather than metabolism ( 14 ). (diabetesjournals.org)
- Among many different methods available for measuring glucose uptake, 2-deoxyglucose (2-DG) has been widely used because of its structural similarity to glucose. (creativebiomart.net)
- A nonradioisotope, enzymatic assay for 2-deoxyglucose uptake in L6 skeletal muscle cells cultured in a 96-well microplate. (sigmaaldrich.com)
- 2-D-Deoxyglucose (2-dGlc) uptake and accumulation into rat peritoneal macrophages was increased by colony-stimulating factor (mCSF) by stimulating the coupling between endofacial hexokinase activity and the sugar transporter. (portlandpress.com)
- Exposure of differentiated L6 myotubes to the CB1 antagonist rimonabant (SR141716) selectively increased 2-deoxyglucose uptake (2-DG) in a time- and dose-dependent manner. (aspetjournals.org)
- Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart. (semanticscholar.org)
- Skeletal muscle glucose uptake (R(g)) in perfused hindlimbs was estimated from the uptake and subsequent phosphorylation of radiolabeled 2-deoxyglucose (2DG) in the gastrocnemius (GN), extensor digitorum longus (EDL), and soleus (SOL) muscles. (elsevier.com)
- Glucose uptake rate, as determined by 31 P-nuclear magnetic resonance spectroscopy measuring 2-deoxyglucose conversion to 2-deoxyglucose-6-phosphate, was measured in isolated perfused hearts obtained from banded rabbits when M/V ratio had increased by 15% from baseline (compensated hypertrophy) and by 30% from baseline (early-decompensated hypertrophy). (ahajournals.org)
- Significance of incidental focal uptake in prostate on 18-fluoro-2-deoxyglucose positron emission tomography CT images. (koreascience.or.kr)
- Is further evaluation needed for incidental focal uptake in the prostate in 18-fluoro-2-deoxyglucose positron emission tomographycomputed tomography images? (koreascience.or.kr)
- The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. (cdc.gov)
- Regions of increased ( 14 C) 2-deoxyglucose (2DG) uptake were mapped autoradiographically in cerebellum. (elsevier.com)
- DESCRIPTION (provided by applicant): A new fluorescent analogue of d-glucose, 2-[N-(7-nitrobenz-2-oxa-1,3-diaxol-4-yl)amino]-2- deoxyglucose (2-NBDG), was recently developed, but has not been characterized as a marker of glucose uptake in cancer cells. (sbir.gov)
- The extent of ischemic and hibernating myocardium, which may be detected by increased postexercise uptake of fluoro-18 deoxyglucose (FDG) using positron emission tomography, may determine the degree of functional benefit after revascularization. (edu.au)
- We examined the effects of μ-opioid receptor agonist and antagonists, and κ-opioid receptor agonist on the hypoxia/hypoglycemia-induced reduction in 2-deoxyglucose uptake of rat hippocampal slices. (elsevier.com)
- Chronic administration of morphine (10 mg/kg) for 9 days affected neither the basal nor the hypoxia/hypoglycemia-induced reduction in 2-deoxyglucose uptake. (elsevier.com)
- Shibata, S , Tominaga, K & Watanabe, S 1995, ' κ-Opioid receptor agonist protects against ischemic reduction of 2-deoxyglucose uptake in morphine-tolerant rats ', European Journal of Pharmacology , vol. 279, no. 2-3, pp. 197-202. (elsevier.com)
- Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and rn" by J Rosen, J Fina et al. (jax.org)
- Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and rna and protein metabolism in lymphosarcoma p1798. (jax.org)
- To investigate the prevalence and clinical significance of incidental prostate fluoro-2-deoxyglucose (FDG) uptake and to evaluate its impact on patient management. (bvsalud.org)
- Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate. (ox.ac.uk)
- We have demonstrated that rat hippocampal slices exposed to oxygen/glucose-free medium showed decreases in 2-deoxyglucose (2-DG) uptake and CA1 field potentials elicited by the stimulation of Schaffer collaterals. (elsevier.com)
- This study investigated whether changing a tumor's oxygenation would alter tumor metabolism, and thus uptake of 18 F-FDG (fluorine-18 deoxyglucose), a marker for glucose metabolism using positron emission tomography (PET). (springer.com)
- The aims were to determine if the maximum standardized uptake value (SUV(max)) of the primary tumor as determined by preoperative (18)F-fluoro-2-deoxyglucose ((18)F-FDG) positron emission tomography (PET) is an independent predictor of overall survival and to assess its prognostic value after stratification according to pathological staging. (qxmd.com)
Positron10
- Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging technique to identify the inflammatory state of atherosclerotic plaque. (clinicaltrials.gov)
- Early assessment with 18F-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography to predict short-term outcome in clear cell renal carcinoma treated with nivolumab. (urotoday.com)
- We reported previously the usefulness of 18F-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to predict prognosis of renal cell carcinoma (RCC) treated with molecular targeted agents. (urotoday.com)
- We report six demented individuals with pathologically verified diffuse Lewy body disease (DLBD) studied with fluoro-deoxyglucose positron emission tomography (FDG-PET). (neurology.org)
- MATERIALS AND METHODS: Thirty-six lesions identified on noncontrast MR in 35 patients with biopsy-proved intracranial tumors were imaged with both T1-weighted Cd-DTPA MR at 1.5 T and [ 18 F]2-fiuoro-2-deoxyglucose (FDG) positron emission tomography (PET). (elsevier.com)
- 18-fluoro-2-deoxyglucose positron emission tomography-computed tomography ( $^{18}F$ -FDG PET/CT) scans are commonly used for the staging and restaging of various malignancies, such as head and neck, breast, colorectal and gynecological cancers. (koreascience.or.kr)
- Metabolic imaging of untreated prostate cancer by positron emission tomography with 18fluorine-labeled deoxyglucose. (koreascience.or.kr)
- 18 F-FDG (fluorine-18 deoxyglucose) has become widely used as a radiolabeled marker for positron emission tomography (PET) imaging of solid tumors. (springer.com)
- PURPOSE: [18F]-Fluoro-d-deoxyglucose positron emission tomography (FDG-PET) is an expensive, invasive, and not widely available technique used in the presurgical evaluation of temporal lobe epilepsy. (tue.nl)
- Moons, K.G.M. / The added value of [18F]-fluoro-D-deoxyglucose positron emission tomography in screening for temporal lobe epilepsy surgery . (tue.nl)
Glycolysis10
- 2-Deoxyglucose (2DG), an inhibitor of glycolysis, abrogates seizure activity and retards epilepsy progression both in vitro and in vivo . (frontiersin.org)
- Previous studies demonstrated that a glycolysis inhibitor, 2-deoxyglucose (2DG), blocks replication of L. pneumophila during infection of macrophages, leading to speculation that L. pneumophila may exploit macrophage glycolysis. (asm.org)
- Once imported into cells and phosphorylated, the glucose analog 2-deoxyglucose (2DG) inhibits glycolysis, leading to the proposal of using 2DG as a cancer treatment. (sciencemag.org)
- The glucose analog 2-deoxyglucose (2DG) is imported into cells and, after phosphorylation, becomes 2DG-6-phosphate, a toxic by-product that inhibits glycolysis. (sciencemag.org)
- Because 2-deoxyglucose (2-DG) is a competitive inhibitor of glycolysis we tested its ability to reduce hyperglycemia-exacerbated ischemic brain damage. (ahajournals.org)
- This study investigated the preclinical efficacy of targeting the tumor bioenergetic pathway using a glycolysis inhibitor 2-deoxyglucose (2DG) and AMPK agonists, AICAR and metformin. (aacrjournals.org)
- Herein, we describe the functional outcomes of glycolysis inhibition by 2-deoxyglucose (2DG) in combination with AMPK agonists, AICAR and metformin. (aacrjournals.org)
- Therefore, the glucose analog 2-deoxyglucose (2DG) has been used as an anticancer reagent due to its inhibition of glycolysis. (altmetric.com)
- A marked age-dependent response was observed with 2-deoxyglucose but not with antimycin A. The results confirm an increase in the rate of glycolysis with ageing, which appears to be independent of cellular mitochondrial respiratory chain capacity. (semanticscholar.org)
- Moreover, we show that treatment with 2-deoxyglucose, a well known inhibitor of glycolysis, inhibits BCSC proliferation when used alone and shows a synergic effect when used in combination with doxorubicin. (unipa.it)
Fluoro-2-deoxyglucose3
- PET for diagnosis of malignant lymphoma of the scalp: comparison of [11C]methyl-L-methionine and [18F]fluoro-2-deoxyglucose. (nih.gov)
- PET demonstrated more intensive and wider accumulation of [11C]methyl-L-methionine (Met) than of [18F]fluoro-2-deoxyglucose (FDG). (nih.gov)
- We investigated the potential of predicting allograft rejection by measuring the ability of graft-infiltrating cells to take up 2-[18F]fluoro-2-deoxyglucose ([18F]FDG). (ovid.com)
Inhibition by 2-deoxyglucose2
- Abstract C156: PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose. (aacrjournals.org)
- Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. (ahajournals.org)
Phosphorylation1
- Effect of 2-deoxyglucose phosphorylation on phosphorus metabolism. (jax.org)
Accumulation1
- The accumulation of phosphorylated 2-deoxyglucose (2DGP) was increased in skeletal muscles by 56-102% and in diaphragm by 236% at 3 h after treatment with 100 micrograms/100 g endotoxin. (physiology.org)
Tumor cells1
- Inhibition of the glycolytic pathway with 2-deoxyglucose leads to sensitization of tumor cells to other apoptotic stimuli(Maschek, G., et al Cancer Res. (aacrjournals.org)
Glycolytic inhibitor3
- Here, we discuss the evidence for one glycolytic inhibitor, 2-deoxyglucose (2DG) and one metabolic substrate, β-hydroxybutyrate (BHB) exerting direct effects on neuronal excitability, highlight their mechanistic differences, and provide the strengthening scientific rationale for their individual or possibly combined use in the clinical arena of seizure management. (frontiersin.org)
- 2-Deoxyglucose (2-DG), a glycolytic inhibitor analog of glucose, is widely investigated in experimental and clinical oncology for targeting glucose metabolism. (aacrjournals.org)
- Our lead compound, developed at the National Institute on Aging, was 2-deoxyglucose, an analogue of the native sugar, that acted as a glycolytic inhibitor, having limited metabolism and actually reducing overall energy flow--analogous to CR. (isharonline.org)
Rats1
- This benchmark article described for the first time the theory and procedure of the quantitative autoradiographic [14C] deoxyglucose method for the quantitative determination of local glucose utilization in the nervous system and the values obtained with it in normal and anesthetized rats. (nih.gov)
Analog1
- The glucose analog 2-deoxyglucose (2dGlc) inhibits the growth and multicellular development of Myxococcus xanthus . (asm.org)
Hexokinase2
- Expression of the Escherichia coli glk (glucokinase) gene in M. xanthus hex mutants restores 2dGlc sensitivity, suggesting that these mutants arise upon the loss of a soluble hexokinase function that phosphorylates 2dGlc to form the toxic intermediate, 2-deoxyglucose-6-phosphate. (asm.org)
- 2-Deoxyglucose (2DG) was detected by measuring a potent fluorophore, resorufin, generated after incubation with a single assay solution containing hexokinase, adenosine 5'-triphosphate, glucose 6-phosphate dehydrogenase, beta-nicotineamide adenine dinucleotide phosphate, diaphorase, and resazurin. (sigmaaldrich.com)
Vitro2
- Differential growth inhibition of human diploid fibroblasts by 2-deoxyglucose and antimycin A with ageing in vitro. (semanticscholar.org)
- The relative growth inhibitory effects of 2-deoxyglucose and antimycin A were monitored at five stages during the life-span in vitro of human diploid fibroblasts. (semanticscholar.org)
Phosphatase2
- In enzymology, a 2-deoxyglucose-6-phosphatase (EC 3.1.3.68) is an enzyme that catalyzes the chemical reaction 2-deoxy-D-glucose 6-phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } 2-deoxy-D-glucose + phosphate Thus, the two substrates of this enzyme are 2-deoxy-D-glucose 6-phosphate and H2O, whereas its two products are 2-deoxy-D-glucose and phosphate. (wikipedia.org)
- This enzyme is also called 2-deoxyglucose-6-phosphate phosphatase. (wikipedia.org)
Autoradiography2
- 14)C]2-deoxyglucose (2-DG) autoradiography was combined with T(2)(*) OC to determine metabolic status of T(2)(*)-defined penumbra. (sinapse.ac.uk)
- Additionally, domains sharing the ocular dominance and orientation preference of the neurons at the injection sites were visualized by 2-deoxyglucose (2-DG) autoradiography. (jneurosci.org)
Abstract1
- abstract = "Radiolabeled deoxyglucose (FDG) has been advocated as a marker of viability of reperfused myocardium during acute infarction. (elsevier.com)
Growth inhibition1
- 1971. Effect of 2-deoxyglucose on cell wall formation in Saccharomyces cerevisiae and its relation to cell growth inhibition. (exeley.com)
Metabolism3
- CONCLUSIONS: Deoxyglucose-induced metabolism inhibition increased the PAP ventilated with 21% O2, but it didn't increase the PAP ventilated with 3% O2. (koreamed.org)
- Previously, we reported that under normal O 2 conditions (21% O 2 ), the dual glucose metabolism inhibitor 2-deoxyglucose (2-DG) activates a cytoprotective autophagic response in cancer cells mainly through the induction of endoplasmic reticulum (ER) stress rather than ATP 2 reduction. (elsevier.com)
- Cerebral blood flow (CBF) rises when the glucose supply to the brain is limited by hypoglycemia or glucose metabolism is inhibited by pharmacological doses of 2-deoxyglucose (DG). (elsevier.com)
Metabolic1
- 1. We have studied the effects of the metabolic inhibitors cyanide (CN) and deoxyglucose (DG) on the intracellular Ca2+ concentration ([Ca2+]i) in macrovascular endothelial cells derived from human umbilical vein (EA cells). (kuleuven.be)
Saccharomyces1
- Saccharomyces cerevisiae MCD4 is a 2-deoxyglucose (2-DOG)-resistant mutant derived from the wild-type strain, AK46, wherein the 2-DOG resistance improves the maltose fermentative ability. (mdpi.com)
Quantitative1
- 2-Deoxyglucose Assay Kit (Fluorometric) is a quantitative fluorometric determination of 2-deoxyglucose. (creativebiomart.net)
Fermentation1
- Beta-fructofuranosidase production by 2-deoxyglucose resistant mutants of aspergillus niger in submerged and solid-state fermentation. (bvsalud.org)
Cells2
- Schizosaccharomyces pombe cells of strains each carrying a deletion of one of the genes snf5, ypa1, pho7 and pas1 and of a strain overexpress-ing gene odr1, have been previously shown to grow in presence of the toxic glucose analogue 2-deoxyglucose (2-DG). (exeley.com)
- Cultures of Chinese Hamster Cells (CCL 16, Don Strain) were treated with 2-Deoxyglucose over varying lengths of time in order to compare the mitotic index with the rate of adenosine triphosphate synthesis. (uni.edu)
Neurons2
- Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parki. (nih.gov)
- Tekkök, S & Krnjević, K 1996, ' Calcium dependence of LTP induced by 2-deoxyglucose in CA1 neurons ', Journal of neurophysiology , vol. 76, no. 4, pp. 2343-2352. (elsevier.com)
Emission1
- A near-infrared fluorophore, IRDye 800CW, emission maximum 794 nm, was conjugated to 2-deoxyglucose (2-DG). (unl.edu)
Assay1
- In 2-Deoxyglucose Assay Kit (Fluorometric), the accumulated 2-DG6P is enzymatically oxidized and coupled to PicoProbe, which generates fluorescence in the presence of NADPH. (creativebiomart.net)
Mutants2
- After ultraviolet mutagenization and selection, seven derepressed mutants resistant to 2-deoxyglucose (2-DG) were isolated on Czapek's minimal medium containing glycerol. (ovid.com)
- After UV mutagenesis of conidiospores of A. niger , 2-deoxyglucose (10 g/l) resistant mutants were isolated on Czapek's minimal medium containing glycerol as a carbon source and the mutants were examined for improved production of beta-fructofuranosidase in SmF and SSF conditions. (bvsalud.org)
Inhibitory1
- Through adaptation in the presence of 2-deoxyglucose, we have generated Zymomonas mobilis strain #7, which is better suited to utilizing xylose in pretreated corn stover (PCS) fermentations in the presence of both glucose and model inhibitory compounds of acetate and furfural. (biomedcentral.com)
Rabbits1
- The rates of local cerebral glucose utilization have been measured in normal conscious and hypnotized rabbits by the [14C]deoxyglucose method. (isharonline.org)
Therapeutic1
- The effects of 2-deoxyglucose on the developing human fetus at the recommended therapeutic dose are unknown. (knowcancer.com)
Insulin1
- 3H]Deoxyglucose plasma half-life and fasting and post-glucose load insulin levels were comparable in the two groups. (ahajournals.org)
Acetate1
- We performed an extended lab-directed evolution of Z. mobilis strain 8b in the presence of acetate and a non-hydrolyzable glucose analogue 2-deoxyglucose. (biomedcentral.com)
Amino1
- n 2-amino-2-deoxyglucose in chitin, mucopolysaccharides, and mucoproteins. (thefreedictionary.com)
Yeast1
- Lysis of yeast cell walls induced by 2-deoxyglucose at their sites of glucan synthesis. (exeley.com)
Effects2
- Effects of 2-deoxyglucose on carbohydrate metablism: review of the literature and studies in the rat. (exeley.com)
- Young, Darrell D. (1972) "The Effects of 2-Deoxyglucose on the ATP Consumption in Cell Cultures," Proceedings of the Iowa Academy of Science, 79(1), 41-43. (uni.edu)
Macrophages1
- Treatment with 2-deoxyglucose (2DG) blocks L. pneumophila replication in mammalian macrophages but has no effect on bacteria grown in broth. (asm.org)
Cancer1
- Introduction: This study proposes the use 2-deoxyglucose (2DG) with the PKM2 activator, TEPP46 as a novel drug combination for cancer chemotherapy. (aacrjournals.org)