AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
DeoxyglucoseDeoxy SugarsGlucoseHexosesAntimetabolitesMethylglucosidesMonosaccharide Transport ProteinsAutoradiographyFluorodeoxyglucose F18Glycolysis3-O-MethylglucoseBiological TransportHexokinaseCarbon RadioisotopesInsulinGlucose-6-PhosphateGlucosephosphatesGlucose Transporter Type 1Glucose Transporter Type 4Glucose Transporter Type 3Tomography, Emission-ComputedBiological Transport, ActiveFluorine RadioisotopesKineticsCytochalasin BBrainRadiopharmaceuticalsAdenosine TriphosphateMannoseTolazamideMethylglycosidesInsulin AntagonistsGlycogenGlucosaminePhosphoenolpyruvate Sugar Phosphotransferase SystemReceptor, InsulinMuscle, SkeletalSodium AzidePhloretin4-Chloro-7-nitrobenzofurazanRats, Inbred StrainsPositron-Emission TomographyFructoseMuscle ProteinsGlucokinaseGalactoseMethylgalactosidesIodoacetatesAntimycin AEnergy MetabolismThiogalactosidesLactatesAdipocytesThioglycosidesMannoheptuloseRats, Sprague-DawleyHexosephosphatesTritiumBlood GlucoseCells, CulturedPhlorhizinAdipose TissuePhosphorylationDinitrophenolsCyanidesGlucose Transport Proteins, FacilitativeLactic AcidMyocardiumCarbohydrate MetabolismCell MembraneRats, WistarSalicylamidesCell LineOligomycinsAminoimidazole CarboxamideIodoacetic AcidUncoupling Agents
Deoxyglucose
2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.
Deoxy Sugars
Glucose
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Hexoses
Antimetabolites
Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)
Methylglucosides
Monosaccharide Transport Proteins
A large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES.
Autoradiography
The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)
Fluorodeoxyglucose F18
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
Glycolysis
A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.
3-O-Methylglucose
A non-metabolizable glucose analogue that is not phosphorylated by hexokinase. 3-O-Methylglucose is used as a marker to assess glucose transport by evaluating its uptake within various cells and organ systems. (J Neurochem 1993;60(4):1498-504)
Biological Transport
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Hexokinase
An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.
Carbon Radioisotopes
Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Glucose-6-Phosphate
An ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)
Glucosephosphates
Glucose Transporter Type 1
A ubiquitously expressed glucose transporter that is important for constitutive, basal GLUCOSE transport. It is predominately expressed in ENDOTHELIAL CELLS and ERYTHROCYTES at the BLOOD-BRAIN BARRIER and is responsible for GLUCOSE entry into the BRAIN.
Glucose Transporter Type 4
A glucose transport protein found in mature MUSCLE CELLS and ADIPOCYTES. It promotes transport of glucose from the BLOOD into target TISSUES. The inactive form of the protein is localized in CYTOPLASMIC VESICLES. In response to INSULIN, it is translocated to the PLASMA MEMBRANE where it facilitates glucose uptake.
Glucose Transporter Type 3
A major glucose transporter found in NEURONS.
Tomography, Emission-Computed
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
Biological Transport, Active
The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.
Fluorine Radioisotopes
Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.
Kinetics
The rate dynamics in chemical or physical systems.
Cytochalasin B
A cytotoxic member of the CYTOCHALASINS.
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Radiopharmaceuticals
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Adenosine Triphosphate
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Mannose
A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)
Tolazamide
A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
Methylglycosides
Insulin Antagonists
Compounds which inhibit or antagonize the biosynthesis or action of insulin.
Glycogen
Glucosamine
Phosphoenolpyruvate Sugar Phosphotransferase System
The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.
Receptor, Insulin
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
Muscle, Skeletal
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Sodium Azide
A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)
Phloretin
4-Chloro-7-nitrobenzofurazan
A benzofuran derivative used as a protein reagent since the terminal N-NBD-protein conjugate possesses interesting fluorescence and spectral properties. It has also been used as a covalent inhibitor of both beef heart mitochondrial ATPase and bacterial ATPase.
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Positron-Emission Tomography
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Fructose
A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.
Muscle Proteins
The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.
Glucokinase
A group of enzymes that catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate. They are found in invertebrates and microorganisms, and are highly specific for glucose. (Enzyme Nomenclature, 1992) EC 2.7.1.2.
Galactose
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
Methylgalactosides
Iodoacetates
Iodinated derivatives of acetic acid. Iodoacetates are commonly used as alkylating sulfhydryl reagents and enzyme inhibitors in biochemical research.
Antimycin A
An antibiotic substance produced by Streptomyces species. It inhibits mitochondrial respiration and may deplete cellular levels of ATP. Antimycin A1 has been used as a fungicide, insecticide, and miticide. (From Merck Index, 12th ed)
Energy Metabolism
The chemical reactions involved in the production and utilization of various forms of energy in cells.
Thiogalactosides
Galactosides in which the oxygen atom linking the sugar and aglycone is replaced by a sulfur atom.
Lactates
Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
Adipocytes
Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.
Thioglycosides
Mannoheptulose
A 7-carbon keto sugar having the mannose configuration.
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Hexosephosphates
Tritium
Blood Glucose
Glucose in blood.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Phlorhizin
Adipose Tissue
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Phosphorylation
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Dinitrophenols
Organic compounds that contain two nitro groups attached to a phenol.
Cyanides
Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.
Glucose Transport Proteins, Facilitative
A family of monosaccharide transport proteins characterized by 12 membrane spanning helices. They facilitate passive diffusion of GLUCOSE across the CELL MEMBRANE.
Lactic Acid
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
Myocardium
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Carbohydrate Metabolism
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.
Cell Membrane
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Rats, Wistar
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Salicylamides
Amides of salicylic acid.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Oligomycins
A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).
Aminoimidazole Carboxamide
An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases.
Iodoacetic Acid
A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.
Uncoupling Agents
Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.

2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages II. Dissociation of the inhibitory effects of 2-deoxyglucose on phagocytosis and ATP generation. (1/2660)

Macrophages incubated in 2-deoxy-D-glucose (2-dG)-containing medium showed a marked decrease in cellular ATP content, and were unable to ingest IgG- and complement-coated erythrocytes via the corresponding membrane receptors for these ligands. However, the inhibitory effects of 2-dG on Fc- and C3 receptor-mediated phagocytosis were not a consequence of lowered macrophage ATP levels since addition of glucose or mannose to the culture medium restored the capacity of the macrophages to ingest IgG- and C3-coated particles without increasing ATP levels. These results indicate that Fc- and C3 receptor-mediated phagocytosis (opsonin dependent) differs qualitatively from the ingestion of latex and zymosan particles (opsonin independent); they suggest that the same regulatory molecules govern the responses of phagocytic cells to signals initiated by both the Fc and C3 receptors. The possibility that these molecules are regulated by glycosylation is discussed.  (+info)

The biological clock of very premature primate infants is responsive to light. (2/2660)

Each year more than 250,000 infants in the United States are exposed to artificial lighting in hospital nurseries with little consideration given to environmental lighting cycles. Essential in determining whether environmental lighting cycles need to be considered in hospital nurseries is identifying when the infant's endogenous circadian clock becomes responsive to light. Using a non-human primate model of the developing human, we examined when the circadian clock, located in the hypothalamic suprachiasmatic nuclei (SCN), becomes responsive to light. Preterm infant baboons of different ages were exposed to light (5,000 lux) at night, and then changes in SCN metabolic activity and gene expression were assessed. After exposure to bright light at night, robust increases in SCN metabolic activity and gene expression were seen at ages that were equivalent to human infants at 24 weeks after conception. These data provide direct evidence that the biological clock of very premature primate infants is responsive to light.  (+info)

Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. (3/2660)

Platelets express leukotriene (LT) C4 synthase and can thus participate in the formation of bioactive LTC4. To further elucidate the relevance of this capability, we have now determined the capacity of human platelets to export LTC4. Endogenously formed LTC4 was efficiently released from human platelets after incubation with LTA4 at 37 degrees C, whereas only 15% of produced LTC4 was exported when the cells were incubated at 0 degrees C. The activation energy of the process was calculated to 49.9 +/- 7.7 kJ/mol, indicating carrier-mediated LTC4 export. This was also supported by the finding that the transport was saturable, reaching a maximal export rate of 470 +/- 147 pmol LTC4/min x 10(9) platelets. Furthermore, markedly suppressed LTC4 transport was induced by a combination of the metabolic inhibitors antimycin A and 2-deoxyglucose, suggesting energy-dependent export. The presence in platelets of multidrug resistance-associated protein 1 (MRP1), a protein described to be an energy-dependent LTC4 transporter in various cell types, was demonstrated at the mRNA and protein level. Additional support for a role of MRP1 in platelet LTC4 export was obtained by the findings that the process was inhibited by probenecid and the 5-lipoxygenase-activating protein (FLAP) inhibitor, MK-886. The present findings further support the physiological relevance of platelet LTC4 production.  (+info)

Mannose inhibits Arabidopsis germination via a hexokinase-mediated step. (4/2660)

Low concentrations of the glucose (Glc) analog mannose (Man) inhibit germination of Arabidopsis seeds. Man is phosphorylated by hexokinase (HXK), but the absence of germination was not due to ATP or phosphate depletion. The addition of metabolizable sugars reversed the Man-mediated inhibition of germination. Carbohydrate-mediated regulation of gene expression involving a HXK-mediated pathway is known to be activated by Glc, Man, and other monosaccharides. Therefore, we investigated whether Man blocks germination through this system. By testing other Glc analogs, we found that 2-deoxyglucose, which, like Man, is phosphorylated by HXK, also blocked germination; no inhibition was observed with 6-deoxyglucose or 3-O-methylglucose, which are not substrates for HXK. Since these latter two sugars are taken up at a rate similar to that of Man, uptake is unlikely to be involved in the inhibition of germination. Furthermore, we show that mannoheptulose, a specific HXK inhibitor, restores germination of seeds grown in the presence of Man. We conclude that HXK is involved in the Man-mediated repression of germination of Arabidopsis seeds, possibly via energy depletion.  (+info)

Developmental regulation of genes mediating murine brain glucose uptake. (5/2660)

We examined the molecular mechanisms that mediate the developmental increase in murine whole brain 2-deoxyglucose uptake. Northern and Western blot analyses revealed an age-dependent increase in brain GLUT-1 (endothelial cell and glial) and GLUT-3 (neuronal) membrane-spanning facilitative glucose transporter mRNA and protein concentrations. Nuclear run-on experiments revealed that these developmental changes in GLUT-1 and -3 were regulated posttranscriptionally. In contrast, the mRNA and protein levels of the mitochondrially bound glucose phosphorylating hexokinase I enzyme were unaltered. However, hexokinase I enzyme activity increased in an age-dependent manner suggestive of a posttranslational modification that is necessary for enzymatic activation. Together, the postnatal increase in GLUT-1 and -3 concentrations and hexokinase I enzymatic activity led to a parallel increase in murine brain 2-deoxyglucose uptake. Whereas the molecular mechanisms regulating the increase in the three different gene products may vary, the age-dependent increase of all three constituents appears essential for meeting the increasing demand of the maturing brain to fuel the processes of cellular growth, differentiation, and neurotransmission.  (+info)

Endothelin stimulates glucose uptake and GLUT4 translocation via activation of endothelin ETA receptor in 3T3-L1 adipocytes. (6/2660)

Endothelin-1 (ET-1) is a 21-amino acid peptide that binds to G-protein-coupled receptors to evoke biological responses. This report studies the effect of ET-1 on regulating glucose transport in 3T3-L1 adipocytes. ET-1, but not angiotensin II, stimulated glucose uptake in a dose-dependent manner with an EC50 value of 0.29 nM and a 2.47-fold stimulation at 100 nM. ET-1 stimulated glucose uptake in differentiated 3T3-L1 cells but had no effect in undifferentiated cells, although ET-1 stimulated phosphatidylinositol hydrolysis to a similar degree in both. The 3T3-L1 cells expressed approximately 560,000 sites/cell of ETA receptor, which was not altered during differentiation. Western blot analysis and immunofluorescence staining show that ET-1 stimulated the translocation of insulin-responsive aminopeptidase and GLUT4 to the plasma membrane. The effect of ET-1 on glucose uptake was blocked by A-216546, an antagonist selective for the ETA receptor. ET-1 treatment did not induce phosphorylation of insulin receptor beta-subunit, insulin receptor substrate-1, or Akt but stimulated the tyrosyl phosphorylation of a 75-kDa protein. Genistein (100 microM), an inhibitor of tyrosine kinases, inhibited ET-1-stimulated glucose uptake. Our results show that ET-1 stimulates GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes via activation of ETA receptor.  (+info)

High concentration of glucose decreases glucose transporter-1 expression in mouse placenta in vitro and in vivo. (7/2660)

Facilitative glucose transporter-1 (GLUT1) is expressed abundantly and has an important role in glucose transfer in placentas. However, little is known about the regulation of GLUT1 expression in placental cells. We studied the changes in placental GLUT1 levels in relation to changes in glucose concentration in vitro and in vivo. In in vitro experiments, dispersed mouse placental cells were incubated under control (5.5 mM) and moderately high (22 mM) glucose concentrations, and 2-deoxyglucose uptake into cells was studied on days 1-5 of culture. After 4 days of incubation under both conditions, GLUT1 mRNA and proten levels were examined by Northern and immunoblot analyses. Treatment of cells with 22 mM glucose resulted in a significant decrease in 2-deoxyglucose uptake compared with control, from day 2 to day 5 of culture. Moreover, GLUT1 mRNA and protein levels on day 4 of culture were significantly reduced in cells incubated with 22 mM glucose compared with control. Next, we rendered mice diabetic by administering 200 micrograms/g body weight streptozotocin (STZ) on day 8 of pregnancy. Animals were killed on day 12 of pregnancy and placental tissues were obtained. [3H]Cytochalasin B binding study was carried out to assess total GLUTs, and GLUT1 mRNA and protein were measured as above. [3H]Cytochalasin B binding sites in placentas from STZ-treated mice were significantly less than those in control mice. Northern and immunoblot analyses revealed a significant decrease in GLUT1 mRNA and protein levels in diabetic mice compared with the controls. These findings suggest that the glucose concentration may regulate the expression of placental GLUT1.  (+info)

Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats. (8/2660)

Previous studies have demonstrated that the ventromedial hypothalamus (VMH) plays a critical role in sensing and responding to systemic hypoglycemia. To evaluate the mechanisms of defective counterregulation caused by iatrogenic hypoglycemia and diabetes per se, we delivered 2-deoxy-glucose (2-DG) via microdialysis into the VMH to produce localized cellular glucopenia in the absence of systemic hypoglycemia. Three groups of awake chronically catheterized rats were studied: 1) nondiabetic (with a mean daily glucose [MDG] of 6.9 mmol/l) BB control rats (n = 5); 2) chronically hypoglycemic nondiabetic (3-4 weeks, with an MDG of 2.7 mmol/l) BB rats (n = 5); and 3) moderately hyperglycemic insulin-treated diabetic (with an MDG of 12.4 mmol/l) BB rats (n = 8). In hypoglycemic rats, both glucagon and catecholamine responses to VMH glucopenia were markedly (77-93%) suppressed. In diabetic rats, VMH 2-DG perfusion was totally ineffective in stimulating glucagon release. The epinephrine response, but not the norepinephrine response, was also diminished by 38% in the diabetic group. We conclude that impaired counterregulation after chronic hypoglycemia may result from alterations of the VMH or its efferent pathways. In diabetes, the capacity of VMH glucopenia to activate the sympathoadrenal system is only modestly diminished; however, the communication between the VMH and the alpha-cell is totally interrupted.  (+info)

The [14C]Deoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization: Theory, Procedure, and Normal Values ...The [14C]Deoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization: Theory, Procedure, and Normal Values ...
Periodical: Sokoloff, Louis, Martin Reivich, Charles Kennedy, M. H. Des Rosiers, C. S. Patlak, K. D. Pettigrew, O. Sakurada, and M. Shinohara. The [14C]Deoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization: Theory, Procedure, and Normal Values in the Conscious and Anesthetized Albino Rat. Journal of Neurochemistry 28, 5 (1977): 897-916. Article. 20 Images ...
https://profiles.nlm.nih.gov/ps/retrieve/ResourceMetadata/NLBBDB
Cerebral glucose utilization is reduced in second test session<...Cerebral glucose utilization is reduced in second test session<...
TY - JOUR. T1 - Cerebral glucose utilization is reduced in second test session. AU - Stapleton, June M.. AU - Morgan, Michael J.. AU - Liu, Xiang. AU - Yung, Babington C K. AU - Phillips, Robert L.. AU - Wong, Dean Foster. AU - Shaya, Elias K.. AU - Dannals, Robert F. AU - London, Edythe D.. PY - 1997/6. Y1 - 1997/6. N2 - Cerebral glucose utilization was higher during the first positron emission tomography (PET) session than during the second session, as assayed using the PET [18F]fluorodeoxyglucose method in male human volunteers. This difference was due largely to data from subjects with low trait anxiety, since subjects with high anxiety showed similar metabolism in both PET sessions. High anxiety subjects showed greater right/left ratios of cerebral metabolism than low-anxiety subjects, particularly during the second PET session. These findings suggest that the level of anxiety may be an important variable to consider in PET studies using multiple sessions.. AB - Cerebral glucose utilization ...
https://jhu.pure.elsevier.com/en/publications/cerebral-glucose-utilization-is-reduced-in-second-test-session-5
Ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices: Protection by 5-HT<sub...Ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices: Protection by 5-HT<sub...
TY - JOUR. T1 - Ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices. T2 - Protection by 5-HT1A receptor agonists and 5-HT2 receptor antagonists. AU - Shigenobu Shibata, Shibata. AU - Yoshifumi Kagami-Ishi, Kagami-Ishi. AU - Keiko Tominaga, Tominaga. AU - Koutaroh Kodama, Kodama. AU - Showa Ueki, Ueki. AU - Shigenori Watanabe, Watanabe. PY - 1992/12/8. Y1 - 1992/12/8. N2 - Various in vitro models have been developed to study ischemia and/or hypoxia. In the present experiment, we examined whether hypoxia/hypoglycemia (ischemia) in rat hippocampal slices reduced the 2-deoxyglucose (2-DG) uptake and CA1 field potentials evoked by stimulation of Schaffer collaterals. Autoradiograms revealed that ischemia for 15 or 20 min reduced 2-DG uptake in the stratum radiatum of the CA1 and the dentate gyrus. Similarly, the CA1 field potentials of slices exposed to ischemia for 15 and 20 min decreased by about 70 and 90% after a 6-h washout. In the second ...
https://waseda.pure.elsevier.com/en/publications/ischemia-induced-impairment-of-2-deoxyglucose-uptake-and-ca1-fiel
Evaluation and Comparison of Various Strategies for Estimating Local Cerebral Glucose Metabolic Rate from Brain Images in...Evaluation and Comparison of Various Strategies for Estimating Local Cerebral Glucose Metabolic Rate from Brain Images in...
Positron emission tomography (PET) in use with F-18 labeled deoxyglucose (FDG) has received considerable attention in recent years for its role in studies of cerebral glucose metabolism. PET...
https://link.springer.com/chapter/10.1007/978-3-642-52247-5_23
Cerebral glucose utilization in polysubstance abuse. - PubMed - NCBICerebral glucose utilization in polysubstance abuse. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/8526968?dopt=Abstract
Plus itPlus it
2-Deoxyglucose (2-DG), a glycolytic inhibitor analog of glucose, is widely investigated in experimental and clinical oncology for targeting glucose metabolism. Inhibition of the glycolytic pathway with 2-deoxyglucose leads to sensitization of tumor cells to other apoptotic stimuli(Maschek, G., et al Cancer Res. 64: 31-34, 2004). A phase I/II clinical trial of 2-DG for the treatment of advanced solid tumors and hormone refractory prostrate cancer has been initiated. One of the objectives of this dose escalation trial was to evaluate PK of 2-DG. The drug was administered orally on a daily schedule for 2 weeks of every 3 week cycle. The standard dose escalation format was followed with a starting dose 30mg/kg, escalated to 45mg/kg and 60mg/kg. So far twelve patients have been accrued for this trial (mean age, 65.4± 9.9 yrs), and all completed the study. Repeated oral administration of 2-DG was well tolerated, with a maximum tolerated dose (MTD) not exceeding 60mg/kg consecutive-day dosing. For the ...
http://cancerres.aacrjournals.org/content/70/8_Supplement/2756
Altmetric - Basic, Clinical, and Therapeutic Aspects of Alzheimers and Parkinsons DiseasesAltmetric - Basic, Clinical, and Therapeutic Aspects of Alzheimers and Parkinsons Diseases
Attention for Chapter 139: Role of the Medial Limbic System in the Memory Process: A Hypothesis Based on a Radioactive 2-Deoxyglucose Study ...
https://www.altmetric.com/details/35958852/chapter/37729686
Publications - Lampidis Cancer FoundationPublications - Lampidis Cancer Foundation
Combining 2-Deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress. Huaping Liu, Metin Kurtoglu, Clara Lucia León-Annicchiarico, Cristina Munoz-Pinedo, Julio Barredo, Guy Leclerc, Jaime Merchan, Xiongfei Liu, Theodore J. Lampidis. 2016 May 10. [Epub ahead of print]. View Article. Targeting cisplatin-resistant human tumor cells with metabolic inhibitors. Sullivan EJ, Kurtoglu M, Brenneman R, Liu H, Lampidis TJ. Cancer Chemother Pharmacol. 2013 Dec 19. [Epub ahead of print]. View Article. Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-D-glucose. Philips KB, Kurtoglu M, Leung HJ, Liu H, Gao N, Lehrman MA, Murray TG, Lampidis TJ. Cancer Chemother Pharmacol. 2013 Dec 1. [Epub ahead of print]. View Article. Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells. Liu H, Kurtoglu M, Cao Y, Xi H, ...
http://lampidisfoundation.org/publications/
In vivo determination of transport and metabolism of deoxyglucose in intestinal tissues | SpringerLinkIn vivo determination of transport and metabolism of deoxyglucose in intestinal tissues | SpringerLink
Experiments were carried out on 11 anesthetized cats (Na-pentobarbital). Uptake of a glucose analogue (2-deoxy- d-glucose) by intestinal mucosa and muscularis from arterial plasma was studied in...
https://link.springer.com/article/10.1007/BF00582589
ARIC PublicationsARIC Publications
Rebholz CM, Grams ME, Chen Y, Gross AL, Sang Y, Coresh JJ. Serum Levels of 1,5-Anhydroglucitol and Risk of Incident End-Stage Renal Disease. Am J Epidemiol. 2017;186(8):952-960. ...
https://sites.cscc.unc.edu/aric/biblio?f%5Bkeyword%5D=1654
Effect of age and high sucrose diet on 2-deoxyglucose uptake in perfused hindlimb<...Effect of age and high sucrose diet on 2-deoxyglucose uptake in perfused hindlimb<...
TY - JOUR. T1 - Effect of age and high sucrose diet on 2-deoxyglucose uptake in perfused hindlimb. AU - Eiffert, K. C.. AU - Stern, J. S.. AU - Horwitz, Barbara A. AU - Larkin, L. M.. AU - McDonald, R. B.. PY - 1993. Y1 - 1993. N2 - The purpose of this investigation was to evaluate insulin-stimulated skeletal muscle glucose uptake in male Fischer 344 rats, age 6, 12, and 27 mo, fed either a sucrose (S: 66.6% sucrose, 17.6% protein, 6.4% fat) or sucrose-free (SF: 66.6% starch, 17.6% protein, 6.4% fat) diet for 3 mo. Skeletal muscle glucose uptake (R(g)) in perfused hindlimbs was estimated from the uptake and subsequent phosphorylation of radiolabeled 2-deoxyglucose (2DG) in the gastrocnemius (GN), extensor digitorum longus (EDL), and soleus (SOL) muscles. Rat hindlimbs were perfused at a rate of 10 ml · min-1 with a modified Krebs Henseleit buffer containing bovine red blood cells (hematocrit: 40%) and 5.85 mmole · L-1 glucose along with 358 pmoles · L-1 followed by 3580 pmoles · L-1 insulin. ...
https://ucdavis.pure.elsevier.com/en/publications/effect-of-age-and-high-sucrose-diet-on-2-deoxyglucose-uptake-in-p
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2-Deoxyglucose autoradiography and histological procedures.Four to 5 d after the tracer injections, domains sharing the ocular dominance and orientation specificity of the injection sites were additionally labeled by 2-[14C]deoxyglucose autoradiography. Anesthesia was induced and maintained as described above and supplemented by a muscle relaxant (Flaxedil, gallamine triethiodide, 160 mg in 50 ml of saline, 3 ml · kg−1 · hr−1; Specia) to prevent eye movements. All strabismic animals (cats C1-C6) were stimulated monocularly through the eye that dominated the neurons at the injection site. The respective nonstimulated eye (left eye in cats C1, C2, C3, and C5; right eye in cats C4 and C6) was covered with a black contact lens and an additional black patch. Simultaneously with the onset of the visual stimulation, the cats received an intravenous injection of 2-deoxy-d-[U-14C]glucose (dose, 100 μCi/kg; specific activity, 295 μCi/mmol; Amersham). Visual stimuli were the same as those used for ...
https://www.jneurosci.org/content/17/14/5480
Greiner Vacuette Glycolytic Inhibitor 4 ml - 454297Greiner Vacuette Glycolytic Inhibitor 4 ml - 454297
VACUETTE Glycolytic Inhibitor, Potassium Oxalate and Sodium Fluoride 4 ml, 13 x 75 mm case of 1200 for use in glucose and lactate determinations. Buy Now!
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Serum 1,5-Anhydroglucitol: Risk Factor of Acute Ischemic Stroke and Transient Ischemic Attack in Well-Controlled DiabetesSerum 1,5-Anhydroglucitol: Risk Factor of Acute Ischemic Stroke and Transient Ischemic Attack in Well-Controlled Diabetes
Background: Serum 1,5-anhydroglucitol (1,5-AG) levels are a measure that provides information on daily glycemic variations. We evaluated whether 1,5-AG could be a possible marker of acute ischemic stroke (AIS) or transient ischemic attacks (TIA) in patients with diabetes mellitus (DM). Methods: We r
https://insights.ovid.com/cbdis/201744050/00008999-201744050-00013
Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and rn by J Rosen, J Fina et al.Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and rn by J Rosen, J Fina et al.
Rosen, J; Fina, J; Milholland, R; and Rosen, F, Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and rna and protein metabolism in lymphosarcoma p1798. (1972). Subject Strain Bibliography 1972. 218 ...
https://mouseion.jax.org/ssbb1972/218/
Hyperpermeability and ATP depletion induced by chronic hypoxia or glycolytic inhibition in Caco-2BBe monolayers - Fingerprint ...Hyperpermeability and ATP depletion induced by chronic hypoxia or glycolytic inhibition in Caco-2BBe monolayers - Fingerprint ...
Fingerprint Dive into the research topics of Hyperpermeability and ATP depletion induced by chronic hypoxia or glycolytic inhibition in Caco-2BBe monolayers. Together they form a unique fingerprint. ...
https://scholars.houstonmethodist.org/en/publications/hyperpermeability-and-atp-depletion-induced-by-chronic-hypoxia-or/fingerprints/
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Insulin binding and 2-deoxy-d-glucose uptake were compared in the soleus, plantaris, and extensor digitorum longus (EDL) muscles, in vitro, since the known biochemical profile of the soleus differs markedly from the other two. The present study showed that insulin binding increased in all three muscles with increasing concentrations of insulin in the range of 0.2- 30 nM. However, the increase in binding of insulin to soleus at each insulin concentration exceeded that observed in the other two muscles (P , 0.05). Differences between the plantaris and EDL were not significant. The quantity of insulin bound at each concentration also increased more rapidly in the soleus than in either the plantaris (P , 0.05) or EDL (P , 0.05). Basal and insulin-stimulated uptake of 2-deoxy-d-glucose was also greater in the soleus than in the other muscles (P , 0.05). Maximal 2-deoxy-d-glucose uptake occurred at 1 nM insulin in each of the three muscles. These results indicate that in metabolically distinct types ...
http://diabetes.diabetesjournals.org/content/30/8/702
Glycolysis InhibitorsGlycolysis Inhibitors
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SV40 Virus Transformation of Mouse 3T3 Cells Does Not Specifically Enhance Sugar Transport | ScienceSV40 Virus Transformation of Mouse 3T3 Cells Does Not Specifically Enhance Sugar Transport | Science
The apparent enhancement of 2-deoxy-D-glucose uptake by mouse 3T3 cells accompanying transformation by SV40 virus is not due primarily to an effect on the transport process but to enhanced phosphorylation of the sugar by intracellular kinases. Moreover, the effect is not specifically a function of the presence of the viral genome, but is a reflection of the overall growth rate and physiological state of the cell. ...
http://science.sciencemag.org/content/179/4079/1238
2-Deoxy-d-glucose - Alfa Chemistry2-Deoxy-d-glucose - Alfa Chemistry
2-Deoxy-d-glucose/ACM154178 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
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2-[2-13c]Acetamido-2-Deoxy-d-glucose - Alfa Chemistry2-[2-13c]Acetamido-2-Deoxy-d-glucose - Alfa Chemistry
2-[2-13c]Acetamido-2-Deoxy-d-glucose/ACM478518897 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
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2-Deoxy-D-glucose | Phion2-Deoxy-D-glucose | Phion
Product Number , 73965300. CAS Number , 154-17-6. EC , 205-823-0. Molecular Formula , C6H12O5. Molecular Weight , 164.16. Storage Temp , Harmonized Tariff code , 29400000. Signal Word , ...
http://phionchemicals.com/product/2-deoxy-d-glucose
Structure Summary for 2O8FStructure Summary for 2O8F
Chain E. (DG)(DA)(DC)(DG)(DG)(DC)(DC)(DG)(DC)(DC)(DG)(DC)(DT)(DA)(DG)(DC)(DG). Chain F. (DC)(DG)(DC)(DT)(DA)(DG)(DC)(DG)(DT)(DG)(DC)(DG)(DG)(DC)(DC)(DG)(DT)(DC) ...
http://ndbserver.rutgers.edu/service/ndb/atlas/summary?searchTarget=PD0955
Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. | HypertensionNitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. | Hypertension
We assessed the effect of the vasodilating calcium channel blocker nitrendipine on glucose tolerance in young spontaneously hypertensive rats (SHR) (n = 15). The nitrendipine group received 1 g/kg chow for 3 weeks. Untreated SHR (n = 14) served as controls. At 3 weeks body weight was comparable, whereas systolic blood pressure was 157 +/- 9 mm Hg in nitrendipine-treated rats versus 191 +/- 10 mm Hg in controls (mean +/- SD, P , .00001). Fasting glucose was 6.8 +/- 2.7 mmol/L in nitrendipine-treated versus 8.9 +/- 1.5 mmol/L in control rats (P , .03). An intravenous glucose tolerance test (300 mg/kg) showed plasma glucose levels at 2, 5, 15, and 30 minutes to be significantly lower in the nitrendipine-treated group versus controls (two-way ANOVA, P , .03). Glucose utilization was estimated by the uptake of [3H]deoxyglucose after its intravenous administration (2 microCi/100 g body wt) to instrumented awake animals. Heart and striated muscle uptake was, respectively, 7983 +/- 5812 and 951 +/- 731 ...
http://hyper.ahajournals.org/content/23/6_Pt_2/1051
Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. | StrokeGlycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. | Stroke
Numerous laboratories have shown that hyperglycemia increases cerebral ischemic damage. This presumably results from increased lactate production and accumulation during ischemia. Although increased tissue lactic acidosis is associated with increased ischemic brain damage, this damage has not been directly linked to glycolytic flux. Because 2-deoxyglucose (2-DG) is a competitive inhibitor of glycolysis we tested its ability to reduce hyperglycemia-exacerbated ischemic brain damage. Severe forebrain ischemia was produced by the four-vessel occlusion model in rats. Four rats received 3 g/kg glucose and saline while a second group (n = 5) was injected with 3 g/kg glucose plus 1.6 g/kg 2-DG. A third group (n = 5) was treated with 1 g/kg glucose plus saline and a fourth group (n = 5) received 1 g/kg glucose and 1.6 g/kg 2-DG. All rats were injected i.p. 10 minutes prior to the ischemic insult with the same volume/kg body weight. All rats receiving the high dose of glucose alone (3 g/kg) were dead ...
http://stroke.ahajournals.org/content/17/5/989
Transport and phosphorylation of 2-deoxy-D-glucose by amphibian retina. Effects of light and darkness. | JGPTransport and phosphorylation of 2-deoxy-D-glucose by amphibian retina. Effects of light and darkness. | JGP
We studied the uptake of 2-deoxy-D-glucose (2DG) and the synthesis of its phosphorylated product 2DG-6-phosphate (2DG-6P) by the retinas of the clawed frog (Xenopus laevis) and the bullfrog (Rana catesbeiana). Autoradiographs showed that most of the retinal 2DG uptake is by the photoreceptor layer. The 2DG accumulation by isolated Xenopus retinas was time and concentration dependent. The Kt for transport was 5.05 mM; Vmax was 6.99 X 10(-10) mol . mg-1 tissue wet weight min-1. The Km for 2DG-6P formation was estimated to be 2-3 mM and Vmax to be approximately 4 x 10(-9) mol . mg-1 min-1. 2DG uptake was inhibited competitively by glucose with a Ki of 2.29 mM. Exposure to light reduced 2DG uptake by no more than 10% as compared with dark uptake. Low sodium or ouabain (10(-4)-10(-7) M) treatment did not significantly alter 2DG uptake as compared with control retinas. In experiments upon intact, anesthetized bullfrogs, light reduced both the total amount of radioactivity acquired by the retina and ...
http://jgp.rupress.org/content/80/2/173
18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer ...18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer ...
Purpose: To evaluate 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography imaging (18FDG-PET) as a predictive, noninvasive, pharmacodynamic (PD) biomarker of response following administration of a small-molecule insulin-like growth factor-1 receptor and insulin receptor (IGF-1R/IR) inhibitor, OSI-906.. Experimental Design: In vitro uptake studies of 3H-2-deoxy glucose following OSI-906 exposure were conducted evaluating correlation of dose with inhibition of IGF-1R/IR as well as markers of downstream pathways and glucose metabolism. Similarly, in vivo PD effects were evaluated in human tumor cell line xenografts propagated in athymic nude mice by 18FDG-PET at 2, 4, and 24 hours following a single treatment of OSI-906 for the correlation of inhibition of receptor targets and downstream markers.. Results: Uptake of 3H-2-deoxy glucose and 18FDG was significantly diminished following OSI-906 exposure in sensitive tumor cells and subcutaneous xenografts (NCI-H292) but not in an insensitive ...
https://clincancerres.aacrjournals.org/content/17/10/3332.abstract
Serum glucose: Effects on tumor and normal tissue accumulation of 2-[F-18]-fluoro-2-deoxy-D-glucose in rodents with mammary...Serum glucose: Effects on tumor and normal tissue accumulation of 2-[F-18]-fluoro-2-deoxy-D-glucose in rodents with mammary...
TY - JOUR. T1 - Serum glucose. T2 - Effects on tumor and normal tissue accumulation of 2-[F-18]-fluoro-2-deoxy-D-glucose in rodents with mammary carcinoma. AU - Wahl, Richard L.. AU - Henry, Christine A.. AU - Ethier, Stephen P.. PY - 1992/6. Y1 - 1992/6. N2 - The positron-emitter-labeled glucose analogue 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) accumulates into many cancers after intravenous injection, but the effect of serum glucose levels on FDG uptake in the tumor has not been extensively studied. In vitro, elevated media glucose levels markedly diminished FDG and FDG 6-phosphate uptake and retention in human adenocarcinoma cells, while insulin had no effect. Mammary cancers were established subcutaneously in 12 rats. Six control rats with mammary tumors were fasted overnight. Hyperglycemia was established in six rats by means of continuous glucose infusion (glucose clamp). All animals were then intravenously administered 50 μCi of FDG. Serum glucose levels were 87 mg/dL (4.83 mmol/L) ...
https://jhu.pure.elsevier.com/en/publications/serum-glucose-effects-on-tumor-and-normal-tissue-accumulation-of--4
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Our previous study demonstrated that microinjection of leptin into the ventromedial hypothalamus (VMH) dramatically increased glucose uptake in the heart, brown adipose tissue (BAT), and skeletal muscles, but not in white adipose tissue (WAT) in conscious unrestrained rats, as assessed in vivo by the 2-[3H]deoxyglucose method. Here we examined the role of the sympathetic nervous system and insulin in enhanced glucose uptake by tissues after hypothalamic leptin injection. Pretreatment with guanethidine significantly suppressed the increased glucose uptake by the tissues in response to leptin injected into the VMH, whereas bilateral adrenal demedullation had no significant effect. Treatment with propranolol but not phenoxybenzamine also decreased significantly enhanced glucose uptake by the tissues. We further examined the interaction of the effects of hypothalamic leptin and insulin administered peripherally by clamping the glucose concentrations at a constant level. When leptin was injected into ...
http://diabetes.diabetesjournals.org/content/48/9/1706
The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells | BMC Cancer | Full...The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells | BMC Cancer | Full...
Recent reports using metabolism regulating drugs showed that nutrient deprivation was an efficient tool to suppress cancer progression. In addition, autophagy control is emerging to prevent cancer cell survival. Autophagy breaks down the unnecessary cytoplasmic components into anabolic units and energy sources, which are the most important sources for making the ATP that maintains homeostasis in cancer cell growth and survival. Therefore, the glucose analog 2-deoxyglucose (2DG) has been used as an anticancer reagent due to its inhibition of glycolysis. Prostate cancer cells (PC3) were treated with 2DG for 6 h or 48 h to analyze the changing of cell cycle and autophagic flux. Rapamycin and LC3B overexpressing vectors were administered to PC3 cells for autophagy induction and chloroquine and shBeclin1 plasmid were used to inhibit autophagy in PC3 cells to analyze PC3 cells growth and survival. The samples for western blotting were prepared in each culture condition to confirm the expression level of
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1640-z/figures/3
Variety and complexity of fluorine-18-labelled fluoro-2-deoxy-D-glucose accumulations in the oral cavity of patients with oral...Variety and complexity of fluorine-18-labelled fluoro-2-deoxy-D-glucose accumulations in the oral cavity of patients with oral...
TY - JOUR. T1 - Variety and complexity of fluorine-18-labelled fluoro-2-deoxy-D-glucose accumulations in the oral cavity of patients with oral cancers. AU - Kito, S.. AU - Koga, H.. AU - Kodama, M.. AU - Habu, M.. AU - Kokuryo, S.. AU - Yamamoto, N.. AU - Oda, M.. AU - Nishino, T.. AU - Zhang, M.. AU - Matsuo, K.. AU - Wakasugi-Sato, N.. AU - Matsumoto-Takeda, S.. AU - Seta, Y.. AU - Yoshiga, D.. AU - Kaneuji, T.. AU - Nogami, S.. AU - Yoshioka, I.. AU - Yamashita, Y.. AU - Tanaka, T.. AU - Miyamoto, I.. AU - Kitamura, C.. AU - Tominaga, K.. AU - Morimoto, Y.. PY - 2013/7. Y1 - 2013/7. N2 - Objectives: To elucidate the points that require attention when interpreting fluorine-18-labelled fluoro-2-deoxy-D-glucose (18F-FDG)/ positron emission tomography (PET) images by demonstration of 18F-FDG accumulation in various areas of the oral cavity other than primary lesions in patients with oral cancers. Methods: 18F-FDG accumulations with a maximal standardized uptake value of over 2.5 in various areas ...
https://tohoku.pure.elsevier.com/en/publications/variety-and-complexity-of-fluorine-18-labelled-fluoro-2-deoxy-d-g
Deoxy-D-glucose, 2-[14C(U)]-, Specific Activity: 250-350mCi (9.25-13.0GBq)/mmol, 250µCi (9.25MBq) | PerkinElmerDeoxy-D-glucose, 2-[14C(U)]-, Specific Activity: 250-350mCi (9.25-13.0GBq)/mmol, 250µCi (9.25MBq) | PerkinElmer
250 µCi quantities of 2-[14C(U)]-Deoxy-D-Glucose (300-350mCi/mmol) are available for your research. Application of [14C]Deoxy-D-Glucose can be found in: glucose transporter isoform GLUT4 gene regulation and mechanisms in insulin resistance, selectively suppressing the quinolinic acid-induced enhancement of anaerobic glycolysis in glial cells, stimulatory effect of d-ephedrine on ß3-adrenoceptors in adipose tissue of rats, glucose utilization in the brain during acute seizure as a useful biomarker for the evaluation of anticonvulsants, etc. ...
https://www-punchout.perkinelmer.com/product/deoxy-d-glucose-2-14c-u-nec720a250uc
Deoxy-D-glucose, 2-[14C(U)]-, Specific Activity: 250-350mCi (9.25-13.0GBq)/mmol, 250µCi (9.25MBq) | PerkinElmerDeoxy-D-glucose, 2-[14C(U)]-, Specific Activity: 250-350mCi (9.25-13.0GBq)/mmol, 250µCi (9.25MBq) | PerkinElmer
250 µCi quantities of 2-[14C(U)]-Deoxy-D-Glucose (300-350mCi/mmol) are available for your research. Application of [14C]Deoxy-D-Glucose can be found in: glucose transporter isoform GLUT4 gene regulation and mechanisms in insulin resistance, selectively suppressing the quinolinic acid-induced enhancement of anaerobic glycolysis in glial cells, stimulatory effect of d-ephedrine on ß3-adrenoceptors in adipose tissue of rats, glucose utilization in the brain during acute seizure as a useful biomarker for the evaluation of anticonvulsants, etc. ...
http://www.perkinelmer.com/product/deoxy-d-glucose-2-14c-u-nec720a250uc
Background Improved glycolysis is definitely a hallmark of cancer metabolism, yet | immune-source.comBackground Improved glycolysis is definitely a hallmark of cancer metabolism, yet | immune-source.com
immune Adenosine Deaminase 1226781-44-7, Rabbit Polyclonal to ZP4 Background Improved glycolysis is definitely a hallmark of cancer metabolism, yet relatively little is definitely known about this phenotype at premalignant stages of progression. a cell collection produced from a patient with early genetically stable Become; however, all cell lines keep active mitochondria. In response to the glycolytic inhibitor 2-deoxyglucose, the most glycolytic cell lines (CP-C and CP-D) experienced the very best suppression of extra-cellular acidification, but were able to compensate with upregulation of oxidative phosphorylation. In addition, these cell lines showed the least expensive compensatory raises in glycolysis in response to mitochondrial uncoupling by 2,4-dinitrophenol. Finally, these cell lines also upregulated their oxidative phosphorylation in response to glucose via the Crabtree effect, and demonstrate a higher range of modulation of air intake. A conclusion/Significance Our results recommend ...
https://www.immune-source.com/2018/02/background-improved-glycolysis-is-definitely-a-hallmark-of-cancer-metabolism-yet/
Serials - Metabolism of 2-deoxy-D-glucose by Bakers yeast | Collection of Czechoslovak Chemical CommunicationsSerials - Metabolism of 2-deoxy-D-glucose by Bakers yeast | Collection of Czechoslovak Chemical Communications
Metabolism of 2-deoxy-D-glucose by bakers yeast. I. Isolation and identification of phosphorylated esters of 2-deoxy-D-glucose ...
http://cccc.uochb.cas.cz/serials/Metabolism-of-2-deoxy-D-glucose-by-Baker-s-yeast/
2-amino-2-deoxy-D-[1, 2-13C2]glucose HCl (D-[1, 2-13C2]glucosamine hydrochloride) - Creative Proteomics2-amino-2-deoxy-D-[1, 2-13C2]glucose HCl (D-[1, 2-13C2]glucosamine hydrochloride) - Creative Proteomics
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Objective: 1, 5-anhydroglucitol (1,5-AG) is a short-term marker of metabolic control in diabetes. Its renal loss is stimulated in hyperglycemic conditions by glycosuria, which results in lowered plasma concentration. As low renal threshold for glucose has been described in HNF-1α MODY, 1,5-AG level may be altered in these patients. The purpose of this study was to assess the 1,5-AG levels in HNF-1α MODY patients and in type 2 diabetes (T2DM) subjects with a similar degree of metabolic control. In addition, we aimed to evaluate this particle as a biomarker for HNF-1α MODY.. Research Design and Methods: We included 33 diabetic patients from the Polish Nationwide Registry of MODY. In addition, we examined 43 T2DM patients and 47 non-diabetic controls. 1,5-AG concentration was measured with an enzymatic assay (GlycoMark). The ROC (receiver operation characteristic) analysis was utilized to evaluate 1,5-AG as a screening marker for HNF-1α MODY.. Results: The mean 1, 5-AG plasma concentration in ...
http://care.diabetesjournals.org/content/early/2008/05/20/dc07-2334
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Aged rats (22 to 24 months) and young control rats (3 months) were tested in a battery of behavioral tests which included tests of learning, place navigation, sensorimotor integration, motor coordination, activity, and exploration. Following testing all animals were analyzed in an unanesthetized state for their local glucose utilization. Significant differences in glucose utilization were found between the aged and young groups on some behaviors and in some brain regions. There was considerable variability in the aged group in both their behavioral performance and their glucose utilization scores; thus, attempts were made to determine whether the variability in the degree of impairment within any particular behavioral test was correlated to the regional glucose utilization scores in any of the 45 brain regions analyzed. In two of the behavioral tests employed (i.e., one for learning and one for place navigation), the decline in performance correlated significantly with the decrement in regional ...
http://www.jneurosci.org/content/4/11/2856
DGCI has granted permission for emergency use of 2-deoxy-D-glucose - News Nation EnglishDGCI has granted permission for emergency use of 2-deoxy-D-glucose - News Nation English
#DGCI has granted permission for emergency use of anti-COVID-19 drug 2-deoxy-D-glucose (2-DG) developed by the Defence Research and Development Organisation
https://english.newsnationtv.com/videos/india/dgci-has-granted-permission-for-emergency-use-of-anti-covid-19-drug-2-deoxy-d-glucose-8/76774
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pathological hypercaptation of the lingula | Case Studiespathological hypercaptation of the lingula | Case Studies
An occasion chest X-ray of a 74-year-old female revealed a thickening in her left lung, and the tumor ... PET SCAN : pathological accumulation of the radioactive marked glucose analogue at the ... PET scan (06/12/07): pathological hypercaptation of the lingula (max. SUV 6.8) 01/2008: left lingular .... ...
http://www.doctorsmedicalopinion.com/search/node/Pathological%20hypercaptation%20of%20the%20lingula
Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries
by Lees, J. P and Poireau, V and Tisserand, V and Grauges, E and Palano, A and Eigen, G and Brown, D. N and Kolomensky, Yu. G and Fritsch, M and Schroeder, T and Hearty, C and Mattison, T. S and McKenna, J. A and So, R. Y and Blinov, V. E and Buzykaev, A. R and zhinin, V. P and Golubev, V. B and Kravchenko, E. A and Onuchin, A. P and Serednyakov, S. I and Skovpen, Yu. I and Solodov, E. P and Todyshev, K. Yu and Lankford, A. J and Gary, J. W and Long, O and Eisner, A. M and Lockman, W. S and Vazquez, W. Panduro and Chao, D. S and Echenard, B and Flood, K. T and Hitlin, D. G and Miyashita, T. S and Ongmongkolkul, P and Rohrken, M and Huard, Z and Meadows, B. T and Pushpawela, B. G and Sokoloff, M. D and Smith, J. G and Wagner, S. R and Bernard, D and Verderi, M and Bettoni, D and Bozzi, C and Calabrese, R and Cibinetto, G and Fioravanti, E and Garzia, I and Luppi, E and Santoro, V and Calcaterra, A and de Sangro, R and Finocchiaro, G and Martellotti, S and Patteri, P and Peruzzi, I. M and Piccolo, ...
https://query.library.utoronto.ca/index.php/search/q?kw=Author:CHEN,%20D
Features of Regional Cerebral Glucose Metabolism Abnormality in Corticobasal Degeneration - Abstract - Dementia and Geriatric...Features of Regional Cerebral Glucose Metabolism Abnormality in Corticobasal Degeneration - Abstract - Dementia and Geriatric...
We studied regional cerebral glucose metabolism in 15 patients with a clinical diagnosis of corticobasal degeneration (CBD), 15 patients with probable Alzheimers disease (AD), and 15 healthy controls
https://www.karger.com/Article/Abstract/17227
Regional cerebral glucose metabolism during and after bilateral cerebral ischemia in the gerbil. | StrokeRegional cerebral glucose metabolism during and after bilateral cerebral ischemia in the gerbil. | Stroke
Cerebral metabolic rate for glucose (CMRG) was measured using the 14C-deoxyglucose technique in a stroke model of the gerbil produced by bilateral common carotid artery occlusion. During 30 minutes of ischemia, 14C-deoxyglucose uptake in the brain was increased along the border zone between the ischemic and nonischemic area and decreased in the ischemic areas. During the early stage of reperfusion (2 or 3 to 30 minutes), CMRG increased 50 to 150% in the cerebral cortex, caudoputamen and thalamus and 270 to 320% in the hippocampus, globus pallidus and amygdala. During the late stage of reperfusion (15 to 45 minutes), heterogeneity of CMRG appeared in the cerebral cortex, caudoputamen and thalamus. CMRG decreased to less than 50% of the control value in the cerebral cortex but remained at 200 to 300% of control in the hippocampus, globus pallidus and amygdala. The latter structures exhibited a larger and more protracted increase in glucose metabolism than the other structures most probably due to ...
http://stroke.ahajournals.org/content/14/4/568
Fluorescent glucose biosensor - WikipediaFluorescent glucose biosensor - Wikipedia
Fluorescent glucose biosensors are devices that measure the concentration of glucose in diabetic patients by means of sensitive protein that relays the concentration by means of fluorescence, an alternative to amperometric sension of glucose. No device has yet entered the medical market, but, due to the prevalence of diabetes, it is the prime drive in the construction of fluorescent biosensors. Keeping glucose levels in check is crucial to minimize the onset of the damage caused by diabetes. As a consequence, in conjunction with insulin administrations, the prime requirement for diabetic patients is to regularly monitor their blood glucose levels. The monitoring systems currently in general use have the drawback of below optimal number of readings, due to their reliance on a drop of fresh blood. Some continuous glucose monitors are commercially available, but suffer from the severe drawback of a short working life of the probe. The majority of these work amperometrically. As a result, there is ...
https://en.wikipedia.org/wiki/Fluorescent_glucose_biosensor
4-Deoxy-4-fluoro-D-glucose 29218-07-3 MSDS, Safety Technical Specifications MSDS4-Deoxy-4-fluoro-D-glucose 29218-07-3 MSDS, Safety Technical Specifications MSDS
4-Deoxy-4-fluoro-D-glucose 29218-07-3 MSDS report, 4-Deoxy-4-fluoro-D-glucose MSDS safety technical specifications search, 4-Deoxy-4-fluoro-D-glucose safety information specifications ect.
http://www.molbase.com/en/msds_29218-07-3-moldata-8901.html
Habenula - ScholarpediaHabenula - Scholarpedia
Amat J, Sparks PD, Matus-Amat P, Griggs J, Watkins LR, Maier SF (2001) The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress. Brain Res 917:118-126. Araki M, McGeer PL, McGeer EG (1984) Retrograde HRP tracing combined with a pharmacohistochemical method for GABA transaminase for the identification of presumptive GABAergic projections to the habenula. Brain Res 304:271-277. Brady JV, Nauta WJ (1955) Subcortical mechanisms in emotional behavior: the duration of affective changes following septal and habenular lesions in the albino rat. J Comp Physiol Psychol 48:412-420. Butler AB, Hodos W (2005) Comparative Vertebrate Neuroanatomy: Evolution and Adaptation. Hoboken, New Jersey: Wiley-Liss. Caldecott-Hazard S, Mazziotta J, Phelps M (1988) Cerebral correlates of depressed behavior in rats, visualized using 14C-2-deoxyglucose autoradiography. J Neurosci 8:1951-1961. Caputo A, Ghiringhelli L, ...
http://www.scholarpedia.org/article/Habenula
Tritiated 2‐deoxy‐D‐glucose: A high‐resolution marker for autoradiographic localization of brain metabolism<...Tritiated 2‐deoxy‐D‐glucose: A high‐resolution marker for autoradiographic localization of brain metabolism<...
TY - JOUR. T1 - Tritiated 2‐deoxy‐D‐glucose. T2 - A high‐resolution marker for autoradiographic localization of brain metabolism. AU - Hammer, Ronald P.. AU - Herkenham, Miles. PY - 1984/1/1. Y1 - 1984/1/1. N2 - The technique for autoradiographic localization of 2‐deoxy‐D‐glucose (2DG) uptake has become a useful method for observing alterations of functional brain activity resulting from experimental manipulation. Autoradiographic resolution is improved using tritiated ([3H]) rather than carbon‐14 ([14C])2DG, due to the lower energy and shorter path of tritium emissions. In addition, lower 2DG uptake by white matter relative to gray matter is exaggerated in the [3H]2DG autoradiographs due to the greater absorption of tritium emissions by lipids. Using [3H]2DG, it is possible to observe differential metabolic labeling in various individual nuclei or portions of nuclei that is unresolvable using [14C]2DG in the awake, normal animal. Heterogeneous patterns of 2DG uptake seen only ...
https://arizona.pure.elsevier.com/en/publications/tritiated-2deoxydglucose-a-highresolution-marker-for-autoradiogra
2-Deoxy-glucose Enhances the Effect of Cisplatin and Pemetrexed in Reducing Malignant Pleural Mesothelioma Cell Proliferation...2-Deoxy-glucose Enhances the Effect of Cisplatin and Pemetrexed in Reducing Malignant Pleural Mesothelioma Cell Proliferation...
Viability with 2-DG was dose-dependent. Cell proliferation with CPDD+PEM on 2D surface was reduced in all cell types, 2-DG inclusion demonstrated a synergistic effect in MSTO and ZL34 cells. Spheroid growth in 3D with CPDD+PEM or CPDD+PEM+2-DG lowered spheroid growth in all cell types.. ...
https://www.mesothelioma-line.com/2-deoxy-glucose-enhances-the-effect-of-cisplatin-and-pemetrexed-in-reducing-malignant-pleural-mesothelioma-cell-proliferation-but-not-spheroid-growth/
ORBi: Browsing ORBiORBi: Browsing ORBi
in Neurology (2004), 63(12), 2332-2340. Objectives: To investigate whether the combination of fluoro-2-deoxy-D-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to ... [more ▼]. Objectives: To investigate whether the combination of fluoro-2-deoxy-D-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to Alzheimer disease ( AD). Method: After 1 year, 8 of 37 patients with MCI converted to AD (22%). Differences in baseline regional glucose metabolic rate (rCMRglc) across groups were assessed on a voxel-based basis using a two-factor analysis of variance with outcome (converters [n = 8] vs nonconverters [n = 29]) and APOE genotype (E4 carriers [E4+] [n = 16] vs noncarriers [E4-] [n = 21]) as grouping factors. Results were considered significant at p , 0.05, corrected for multiple comparisons. Results: All converters showed reduced rCMRglc in ...
https://orbi.uliege.be/browse?type=datepublished&rpp=20&value=2004
Peters Blog: January 2011Peters Blog: January 2011
Neurofunctional Imaging of Plasticity in Mouse Somatic Sensory Cortex during Development and in Maturity: The color-coded images show energy metabolism in sections cut tangentially through the right cortical hemisphere. The quantitative autoradiographic deoxyglucose method was employed for neurofunctional imaging. Outlines of the barrels in somatic sensory cortex are superimposed on the images (The nose is to the right; the midline is up). When six whiskers, that is whiskers B1-3 and D1-3, on the left side were stimulated, focal regions of increased metabolic nerve cell activity (red) were found co-localized with the corresponding barrels B1-3 and D1-3 (top image; row A is outside the plane of section; the arrow points at barrel E1). The distinct gap of low activity between the highly activated regions comprises barrels C1-3. When the follicles of whiskers C1-3 were removed on the day of birth, the barrels that would have represented these whisker did not develop and the adjacent barrels ...
http://brainmindinst.blogspot.com/2011/01/
Experimental study for cancer diagnosis with positron-labeled fluorinated glucose analogs: [<sup>18</sup>F]-2-fluoro-2-deoxy-D...Experimental study for cancer diagnosis with positron-labeled fluorinated glucose analogs: [<sup>18</sup>F]-2-fluoro-2-deoxy-D...
TY - JOUR. T1 - Experimental study for cancer diagnosis with positron-labeled fluorinated glucose analogs. T2 - [18F]-2-fluoro-2-deoxy-D-mannose: A new tracer for cancer detection. AU - Fukuda, Hiroshi. AU - Matsuzawa, Taiju. AU - Abe, Yoshinao. AU - Endo, Satoshi. AU - Yamada, Kenji. AU - Kubota, Kazuo. AU - Hatazawa, Jun. AU - Sato, Tachio. AU - Ito, Masatoshi. AU - Takahashi, Toshihiro. AU - Iwata, Ren. AU - Ido, Tatsuo. PY - 1982/7/1. Y1 - 1982/7/1. N2 - 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) and 18F-2-fluoro-2-deoxy-D-mannose (18F-FDM) were tested as tumor diagnostic agents in a transplantable rat tumor and rabbit tumors. Tissue distribution studies in rats showed high tumor uptakes of both radiopharmaceuticals. The tumor uptake reached 2.65±0.61% dose 18F-FDG/g and 2.65±0.81% dose 18F-FDM/g at 60 min and remained relatively constant until 120 min. Blood clearance of both 18F-FDG and 28F-FDM was very rapid and tumor-to-blood ratios reached 22.1 and 29.4 at 60 min, respectively. ...
https://tohoku.pure.elsevier.com/en/publications/experimental-study-for-cancer-diagnosis-with-positron-labeled-flu
Determination of the deoxyglucose and glucose phosphorylation ratio and the lumped constant in rat brain and a transplantable...Determination of the deoxyglucose and glucose phosphorylation ratio and the lumped constant in rat brain and a transplantable...
Mitochondrially bound hexokinase (ATP-D-hexose-6-phosphotransferase; EC 2.7.1.1) was dissociatively extracted from normal rat brains and intracerebral and subcutaneous implants of the 36B-10 glioma. At least 70% of the total hexokinase enzyme activity in normal and glioma tissue was associated with …
https://pubmed.ncbi.nlm.nih.gov/2723662/?dopt=Abstract
Initial experience with continuous intra-arterial fluorescent glucose monitoring in patients in the ICU following cardiac...Initial experience with continuous intra-arterial fluorescent glucose monitoring in patients in the ICU following cardiac...
The sensor was successfully deployed in all five patients and did not interfere with clinical care, blood pressure monitoring or sampling. One patient suffered a cardiopulmonary arrest; the sensor functioned successfully during resuscitation and urgent return to the operating room. One hundred and twenty reference samples ranging from 5.9 to 13.4 mmol/l were collected; 107/120 (89.2%) of GluCath measurements met ISO 15197 criteria (within ±20% of reference when BG ,4.2 mmol/l; Figure 1). In Subject 1 the sensor was inadvertently retracted into the arterial catheter during the study, leading to measurement error from arterial flush solution contamination. In a sensitivity analysis excluding this patient, 89/95 (93.7%) of measurements met ISO 15197 with a mean absolute relative difference of 9.4 ...
https://rd.springer.com/article/10.1186/cc10781
Metabolic control of resistance of human epithelial cells to H2O2 and NO stresses | Biochemical Journal | Portland PressMetabolic control of resistance of human epithelial cells to H2O2 and NO stresses | Biochemical Journal | Portland Press
The carbon flux through the oxidative branch of the pentose phosphate pathway (PPP) can be viewed as an integrator of the antioxidant mechanisms via the generation of NADPH. It could therefore be used as a control point of the cellular response to an oxidative stress. Replacement of glucose by galactose sensitized the human epithelial cell line HGT-1 to H2O2 stress. Here we demonstrate that, due to the restricted galactose flux into the PPP, the H2O2 stress led to early cellular blebbing followed by cell necrosis, these changes being associated with a fall in the NADPH/NADP+ ratio and GSH depletion. H2O2 cytotoxicity was prevented by adding 2-deoxyglucose (2dGlc). This protection was associated with an increased flow of 2-deoxyglucose 6-phosphate into the oxidative branch of the PPP together with the prevention of the NADPH/NADP+ fall and the maintenance of intracellular GSH redox homoeostasis. Inhibitors of enzyme pathways connecting the PPP to GSH recycling abolished the 2dGlc protection. In ...
https://portlandpress.com/biochemj/article-abstract/364/2/349/39731/Metabolic-control-of-resistance-of-human?redirectedFrom=fulltext
what does glycolysis producewhat does glycolysis produce
Glycolysis simply means the breakdown (lysis) of glucose and consists of a series of chemical reactions that are controlled by enzymes. How does glycolysis produce ATP? Important Facts about Glycolysis (cont. Glycolysis Inhibitors Upregulation of glycolysis with increase in glucose consumption for metabolic pathways to generate ATP is the universal property of all the cancers and tumors. 1 ATP, 3 NADH, and 1 FADH2 2 ATPs and 2 NADH 3 NADH and 1 FADH2 4 ATPs, 6 NADH, and 2 FADH2 Newtons second law states that force is equal to mass times acceleration: F = ma. Im aware that ultimately in the human body, after sugar is converted into pyruvate, then if fermentation happens it will be converted into lactate, or if aerobic respiration happens then it wont. ATP is created directly from glycolysis through the process of substrate-level phosphorylation (SLP) and indirectly by oxidative phosporylation (OP). Does Glycolysis produce lactate, or pyruvate? Something as complicated as cellular respiration ...
https://lamenuiserie.net/red-velvet-pkkerjt/what-does-glycolysis-produce-721fed
Sarcomas represent a diverse group of malignancies with distinct pathological andSarcomas represent a diverse group of malignancies with distinct pathological and
Sarcomas represent a diverse group of malignancies with distinct pathological and molecular features. and regular cells. Curiously, inhibitors of mitochondrial breathing do not really considerably impact viability, but had been capable to boost level of sensitivity of sarcomas to inhibition of glycolysis. Additionally, inhibition of glycolysis considerably decreased intracellular ATP amounts, and level of sensitivity to 2-DG-induced development inhibition was related to respiratory prices and glycolytic addiction. Our results demonstrate book human relationships between sarcoma bioenergetics and level of sensitivity to metabolic inhibitors, and recommend that inhibition of metabolic paths in sarcomas should become additional looked into as a potential restorative technique. < 0.05, indicating that WHI-P 154 IC50 cells that are more reliant on glycolysis possess WHI-P 154 IC50 lower ATP-linked respiration rates. Level of sensitivity of human being sarcoma cells to glycolysis inhibition To examine ...
http://researchhunt.com/2017/11/05/sarcomas-represent-a-diverse-group-of-malignancies-with-distinct-pathological-and/
Plus itPlus it
Introduction: Metabolic adaptations favor survival of cancer cells with higher glucose uptake. 2-Deoxy-glucose (2DG), a mimetic of glucose cannot undergo further glycolysis and hampers cell growth, essential during tumor metabolism. Chemotherapy with Cisplatin (Cis) and Pemetrexed (Pem) is the main treatment for malignant pleural mesothelioma (MPM). However, there is lack of evidence on the effects of 2DG in MPM.. Aim: To assess the synergistic effect of 2DG with Cis+Pem during cell migration in wound scratch assay.. Methods: Epithelioid (M14K), biphasic (MSTO) and sarcomatoid (ZL34) MPM cells were used in the study. Cells were grown into confluent monolayers and wounded. Wound widths were measured by microscopic imaging immediately and 8 hours after wound scratch in 10%FBS-RPMI (con), Cis(10μM)+Pem(200μM) or 2DG(3mM)+Cis+Pem. Statistical analyses were performed to assess cell migration.. Results: Migration with both treatments (Cis+Pem, 2DG+Cis+Pem) was significantly reduced compared to ...
https://erj.ersjournals.com/content/54/suppl_63/PA3099
Pi Chemicals System - PI-15720 2-Deoxy-D-glucose (154-17-6)Pi Chemicals System - PI-15720 2-Deoxy-D-glucose (154-17-6)
Provide fine chemicals, building blocks and pharmaceutical intermediates. PI-15720 2-Deoxy-D-glucose (154-17-6) Synonym: Molecular Formula: C6H12O5 Weight: 164.16 CAS No: 154-17-6 Appearance: white crystalline solid Purity:98.0% FM Point:146-147℃ Order online from laboratory chemical supplier and distributor.
http://pipharm.com/catalog/PI-15720.html
Cell count | Zellanalys to » Metabolism and Human T Cell ProliferationCell count | Zellanalys to » Metabolism and Human T Cell Proliferation
The relationship between T-cell metabolism and T cell effector function is little studied for human T cells. A recent publication by K. Renner et al. now reports about investigations of the group with human CD4 and CD8 T cells.. The authors used the CASY, to accurately and reliably determine the cell number and cell volume in proliferation assays and metabolic restriction experiments.. Read the publication here:. Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions. Kathrin Renner, Anna-Lena Geiselhöringer, Matthias Fante, Christina Bruss, Stephanie Dyer, Gabriele Saeed hammer, Katrin Peter, Katrin singer, Reinhard Andreesen, Petra Hoffmann, Peter Abubakar, Wolfgang Mr, Marina Kreutz.. Eur J Immunol. 2015 Sep;45(9):2504-16. two: 10.1002/eji.201545473. ...
https://cellcounting.de/metabolismus-und-proliferation-humaner-t-zellen/?lang=en
Plus itPlus it
In the present study, we have shown the antitumoral effect generated by the lis/lin/GO treatment. The linamarase/linamarin system induces cell death in a proportional manner to the linamarin concentration, destroying the entire cell culture in ∼96 to 120 hours. Cyanide mainly inhibits oxidative phosphorylation, the most important cellular source of energy. However, several studies had reported that the mitochondrial function is impaired in tumor cells, resulting in an elevated rate of glycolysis (30-32), which would circumvent the described therapy. In this context, we tried to combine lis/lin system with subtoxic amounts of the glycolysis inhibitor 3-bromo-pyruvate and we did not find any improvement of the therapy (data not shown). We have nevertheless investigated a combination that increases the system aggressiveness by combining a cyanide-inducing process with a nontoxic amount of GO that accelerates death by 48 hours. In the conditions we have used, GO advances cell death without causing ...
http://mcr.aacrjournals.org/content/6/3/407
Glucose Archives - Focus BiomoleculesGlucose Archives - Focus Biomolecules
2-NBD-Glucose (186689-07-6) is a fluorescent glucose uptake probe. May be used to monitor glucose uptake in live cells and as a cell viability indi ...
https://focusbiomolecules.com/cellular-metabolism/glucose/
AbstractAbstract
There are two main pathways of ATP biosynthesis: glycolysis and oxidative phosphorylation. As a rule, the two pathways are not fully active in a single cell. In this review, we discuss mechanisms of glycolytic inhibition of respiration (Warburg and Crabtree effects). What are the reasons for the existence of this negative feedback? It is known that maximal activation of both processes can cause generation of reactive oxygen species. Oxidative phosphorylation is more efficient from the energy point of view, while glycolysis is safer and favors biomass synthesis. This might be the reason why quiescent cells are mainly using oxidative phosphorylation, while the quickly proliferating ones - glycolysis ...
http://protein.bio.msu.ru/biokhimiya/contents/v80/abs/80050662.html
65kwv10142gfasaml2mt2dg4lblt91gu-keyword ideas generator65kwv10142gfasaml2mt2dg4lblt91gu-keyword ideas generator
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Energy metabolism and t-cell-mediated cytolysis. II. Selective inhib by H R. MacdonaldEnergy metabolism and t-cell-mediated cytolysis. II. Selective inhib by H R. Macdonald
Macdonald, H R., Energy metabolism and t-cell-mediated cytolysis. II. Selective inhibition of cytolysis by 2-deoxy-d-glucose. (1977). Subject Strain Bibliography 1977. 1211 ...
https://mouseion.jax.org/ssbb1977/1211/
SAUSA300 0820 - AureoWikiSAUSA300 0820 - AureoWiki
Cell structureCell envelopeBiosynthesis and degradation of surface polysaccharides and lipopolysaccharidesTDP-4-keto-6-deoxy-D-glucose transaminase (TIGR02379; HMM-score: 21) ...
http://aureowiki.med.uni-greifswald.de/SAUSA300_0820
2-Deoxy-2-Phthalimido-tri-acetofluoro-alpha-D-glucose › PeptaNova2-Deoxy-2-Phthalimido-tri-acetofluoro-alpha-D-glucose › PeptaNova
2-Deoxy-2-Phthalimido-tri-acetofluoro-alpha-D-glucose2-Deoxy-2-Phthalimido-3,4,6-Tri-O-Acetyl-alpha-D-Glucopyranosyl Fluoride22004 1g | ...
https://www.peptanova.de/product/2-deoxy-2-phthalimido-tri-acetofluoro-alpha-d-glucose/
Structure Summary for 2FMPStructure Summary for 2FMP
Chain T. (DC)(DC)(DG)(DA)(DC)(DG)(DG)(DC)(DG)(DC)(DA)(DT)(DC)(DA)(DG)(DC). Chain D. (DG)(DT)(DC)(DG)(DG). Chain P. (DG)(DC)(DT)(DG)(DA)(DT)(DG)(DC)(DG)(DOC) ...
http://ndbserver.rutgers.edu/service/ndb/atlas/summary?searchTarget=2fmp
2-deoxy-D-gluconate 3-dehydrogenase2-deoxy-D-gluconate 3-dehydrogenase
Eichhorn MM, Cynkin MA (January 1965). "Microbial metabolism of 2-deoxyglucose; 2-deoxyglucose acid dehydrogenase". ...
https://en.wikipedia.org/wiki/2-deoxy-D-gluconate_3-dehydrogenase
Herman S. BachelardHerman S. Bachelard
Bachelard, HS (May 1972). "Deoxyglucose and brain glycolysis". The Biochemical Journal. 127 (5): 83P. doi:10.1042/bj1270083pa. ...
https://en.wikipedia.org/wiki/Herman_S._Bachelard
UDP-glucose 6-dehydrogenaseUDP-glucose 6-dehydrogenase
"Uridine diphosphate 2-deoxyglucose. Chemical synthesis, enzymic oxidation and epimerization". Biochimica et Biophysica Acta. ...
https://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase
Para-ChloroamphetaminePara-Chloroamphetamine
A 2-deoxyglucose study in rats". Neuropsychopharmacology. 13 (3): 215-22. doi:10.1016/0893-133X(95)00053-G. PMID 8602894. Lin ...
https://en.wikipedia.org/wiki/Para-Chloroamphetamine
Dopamine hypothesis of stutteringDopamine hypothesis of stuttering
... deoxyglucose study of developmental stuttering". NeuroReport. 6 (3). Blomgren, Michael; Nagarajan, Srikantan S.; Lee, James N ...
https://en.wikipedia.org/wiki/Dopamine_hypothesis_of_stuttering
Thomas KilduffThomas Kilduff
Kilduff TS, Miller JD, Radeke CM, Sharp FR, Heller HC (1990). "14C-2-deoxyglucose uptake in the ground squirrel brain during ... Kilduff TS, Sharp FR, Heller HC (1982). "[14C]2-deoxyglucose uptake in ground squirrel brain during hibernation". Neuroscience ...
https://en.wikipedia.org/wiki/Thomas_Kilduff
Bilikere DwarakanathBilikere Dwarakanath
"B S Dwarakanath's Research on Deoxyglucose (2 Deoxy D glucose) , CureHunter". www.curehunter.com. Retrieved 23 July 2020. " ...
https://en.wikipedia.org/wiki/Bilikere_Dwarakanath
2-Deoxy-D-glucose2-Deoxy-D-glucose
2-Deoxyglucose has been proposed by Garriga-Canut et al. as a mimic for the ketogenic diet, and shows great promise as a new ... glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate intracellularly (with ... 2-Deoxyglucose labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where ... Wick, AN; Drury, DR; Nakada, HI; Wolfe, JB (1957). "Localization of the primary metabolic block produced by 2-deoxyglucose" ( ...
https://en.wikipedia.org/wiki/2-Deoxy-D-glucose
William J. SchwartzWilliam J. Schwartz
Glucose consumption was studied via a technique using 14C-deoxyglucose (DG). DG is transported into the brain via the same ... Schwartz WJ, Gainer H. "Suprachiasmatic nucleus: use of 14C-labeled deoxyglucose uptake as a functional marker." Science. 1977 ... Schwartz demonstrated that the suprachiasmatic nucleus is rhythmic in vivo using a 2-deoxyglucose radioactive marker for ... mechanism which transports glucose, where it is then phosphorylated by hexokinase into 14C-deoxyglucose-6-phosphate(DG-6-P). ...
https://en.wikipedia.org/wiki/William_J._Schwartz
Caloric restriction mimeticCaloric restriction mimetic
2-Deoxyglucose was the first agent pursued as a possible CRM. This compound inhibits glycolysis, and can mimic some of the ...
https://en.wikipedia.org/wiki/Caloric_restriction_mimetic
Electronic fluency deviceElectronic fluency device
1995). "A positron emission tomography [18F]deoxyglucose study of developmental stuttering". NeuroReport. 6 (3): 501-5. doi: ...
https://en.wikipedia.org/wiki/Electronic_fluency_device
Retronasal smellRetronasal smell
2-deoxyglucose (2DG) is a radioactive glucose isotope that can be tracked in the brain since it leaves a trace in the cell ... This method is not terminal as is the 2-deoxyglucose method, so one animal can be measured with many odors, and the resulted ... "Functional organization of rat olfactory bulb analysed by the 2-deoxyglucose method". The Journal of Comparative Neurology. 185 ...
https://en.wikipedia.org/wiki/Retronasal_smell
RadiopharmacologyRadiopharmacology
An example is fludeoxyglucose in which fluorine-18 is incorporated into deoxyglucose. Some radioisotopes (for example gallium- ...
https://en.wikipedia.org/wiki/Radiopharmacology
Society for Research on Biological RhythmsSociety for Research on Biological Rhythms
Schwartz WJ, Gainer H (1977). "Suprachiasmatic nucleus: use of 14C-labeled deoxyglucose uptake as a functional marker". Science ... 2-deoxyglucose Paul Taghert: discovery of PDF's function as a coupling factor in the Drosophila clock Joseph Takahashi: ...
https://en.wikipedia.org/wiki/Society_for_Research_on_Biological_Rhythms
Cortical columnCortical column
"Orientation columns in macaque monkey visual cortex demonstrated by the 2-deoxyglucose autoradiographic technique". Nature. 269 ...
https://en.wikipedia.org/wiki/Cortical_column
UDP-sulfoquinovose synthaseUDP-sulfoquinovose synthase
The systematic name of this enzyme class is UDP-6-sulfo-6-deoxyglucose sulfohydrolase. Other names in common use include ...
https://en.wikipedia.org/wiki/UDP-sulfoquinovose_synthase
Unfolded protein responseUnfolded protein response
A23187 upregulates expression of ER stress proteins 2-deoxyglucose dithiothreitol reduces the disulfide bridges of proteins. ...
https://en.wikipedia.org/wiki/Unfolded_protein_response
SLC2A9SLC2A9
... stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthr. Cartil. 11 (2 ...
https://en.wikipedia.org/wiki/SLC2A9
MetastasectomyMetastasectomy
Wiering B, Krabbe PF, Jager GJ, Oyen WJ, Ruers TJ (December 2005). "The impact of fluor-18-deoxyglucose-positron emission ...
https://en.wikipedia.org/wiki/Metastasectomy
SLC2A6SLC2A6
... stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthritis and ...
https://en.wikipedia.org/wiki/SLC2A6
1,5-Anhydroglucitol1,5-Anhydroglucitol
Yoshioka S, Saitoh S, Negishi C, Fujisawa T, Takatani O, Imura M, Funagashi M (1983). "Variations of 1-deoxyglucose (1,5- ...
https://en.wikipedia.org/wiki/1,5-Anhydroglucitol
HypothalamusHypothalamus
Food intake is rapidly increased by intraventricular administration of 2-deoxyglucose therefore decreasing glucose utilization ...
https://en.wikipedia.org/wiki/Hypothalamus
HDHD1AHDHD1A
... induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose ...
https://en.wikipedia.org/wiki/HDHD1A
Fluorodeoxyglucose (18F)Fluorodeoxyglucose (18F)
... giving the protected fluorinated deoxyglucose (3). Base hydrolysis removes the acetyl protecting groups, giving the desired ...
https://en.wikipedia.org/wiki/Fluorodeoxyglucose_(18F)
AcadesineAcadesine
August 2007). "5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake ...
https://en.wikipedia.org/wiki/Acadesine
Behavioral neuroscienceBehavioral neuroscience
Likewise, the injection of 2-deoxyglucose prior to some behavioral task can be followed by anatomical localization of that ...
https://en.wikipedia.org/wiki/Behavioral_neuroscience
Monolysocardiolipin acyltransferaseMonolysocardiolipin acyltransferase
MLCL AT-1 activity increases in cells cardiac myoblast cells exposed to 2-deoxyglucose-induced apoptosis. MLCL AT-1 activity ... acyltransferase is elevated in the surviving population of H9c2 cardiac myoblast cells exposed to 2-deoxyglucose-induced ...
https://en.wikipedia.org/wiki/Monolysocardiolipin_acyltransferase
FluorodeoxyglycosylamineFluorodeoxyglycosylamine
Reductive amination of hydrophilic 18F-fluoro-2-deoxyglucose with lipophilic amines for development of potential PET imaging ...
https://en.wikipedia.org/wiki/Fluorodeoxyglycosylamine
Orientation columnOrientation column
His technique used photodiodes to detect optical changes in the visual cortex with the metabolic marker, 2-deoxyglucose, which ...
https://en.wikipedia.org/wiki/Orientation_column
BuforminBuformin
Yakisich JS, Azad N, Kaushik V, Iyer AK (2019). "The Biguanides Metformin and Buformin in Combination with 2-Deoxy-glucose or ...
https://en.wikipedia.org/wiki/Buformin
Deoxyglucose - WikipediaDeoxyglucose - Wikipedia
Deoxyglucose may refer to: 1,5-Anhydroglucitol (1-deoxyglucose) 2-Deoxy-D-glucose (2-deoxyglucose) This set index page lists ...
https://en.wikipedia.org/wiki/Deoxyglucose
2-deoxyglucose-6-phosphatase - Wikipedia2-deoxyglucose-6-phosphatase - Wikipedia
In enzymology, a 2-deoxyglucose-6-phosphatase (EC 3.1.3.68) is an enzyme that catalyzes the chemical reaction 2-deoxy-D-glucose ... This enzyme is also called 2-deoxyglucose-6-phosphate phosphatase. Favello A; Fulton L; Gattung S; et al. (1994). "Complete ... two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed". Yeast. 11 (13): 1233-1240. ...
https://en.wikipedia.org/wiki/2-deoxyglucose-6-phosphatase
2-Deoxyglucose, MO-TMS2-Deoxyglucose, MO-TMS
In vivo determination of transport and metabolism of deoxyglucose in intestinal tissues | SpringerLinkIn vivo determination of transport and metabolism of deoxyglucose in intestinal tissues | SpringerLink
Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettegrew KD, Sakurada O, Shinohara M (1977) The14C-deoxyglucose ... Wick AN, Drury DR, Nakada HI, Wolfe JB (1957) Localisation of the primary metabolic block produced by 2-deoxyglucose. J Biol ... In vivo determination of transport and metabolism of deoxyglucose in intestinal tissues. ... of14C labeled deoxy-glucose (DG) was determined. The method can also be used for estimating tissue glucose uptake. The rate ...
https://link.springer.com/article/10.1007/BF00582589
Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. | HypertensionNitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. | Hypertension
Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats.. M Bursztyn, I Raz, J Mekler, D Ben-Ishay ... Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats.. M Bursztyn, I Raz, J Mekler and D Ben- ... Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats.. M Bursztyn, I Raz, J Mekler and D Ben- ... Deoxyglucose plasma half-life and fasting and post-glucose load insulin levels were comparable in the two groups. The results ...
http://hyper.ahajournals.org/content/23/6_Pt_2/1051
AuNP-DG: Deoxyglucose-Labeled Gold Nanoparticles as X-ray Computed Tomography Contrast Agents for Cancer Imaging | SpringerLinkAuNP-DG: Deoxyglucose-Labeled Gold Nanoparticles as X-ray Computed Tomography Contrast Agents for Cancer Imaging | SpringerLink
AuNP-DG: Deoxyglucose-Labeled Gold Nanoparticles as X-ray Computed Tomography Contrast Agents for Cancer Imaging. ...
https://link.springer.com/article/10.1007%2Fs11307-010-0299-8
Frontiers | 2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure Control | Cellular NeuroscienceFrontiers | 2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure Control | Cellular Neuroscience
2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure Control. Jong M. Rho1,2,3*, Li-Rong Shao4 and Carl E. ... 2-Deoxyglucose Versus/Plus Ketone Bodies. From the foregoing discussion, it is important to note both 2DG and the KD can ... 2-Deoxyglucose, A Glycolysis Inhibitor. As mentioned above, the KD mimics fasting in restricting the intake of the main source ... 2-Deoxyglucose (2DG), an inhibitor of glycolysis, abrogates seizure activity and retards epilepsy progression both in vitro and ...
https://www.frontiersin.org/articles/10.3389/fncel.2019.00172/full
Fluorinated deoxyglucose positron emission tomography imaging in progressive metastatic prostate cancerFluorinated deoxyglucose positron emission tomography imaging in progressive metastatic prostate cancer
... Urology. 2002 Jun;59(6 ... and bone scan with fluorinated deoxyglucose positron emission tomography (FDG-PET) in patients with progressive metastatic ...
https://pubmed.ncbi.nlm.nih.gov/12031380/?dopt=Abstract
PET for diagnosis of malignant lymphoma of the scalp: comparison of [11C]methyl-L-methionine and [18F]fluoro-2-deoxyglucose. -...PET for diagnosis of malignant lymphoma of the scalp: comparison of [11C]methyl-L-methionine and [18F]fluoro-2-deoxyglucose. -...
PET for diagnosis of malignant lymphoma of the scalp: comparison of [11C]methyl-L-methionine and [18F]fluoro-2-deoxyglucose.. ... PET demonstrated more intensive and wider accumulation of [11C]methyl-L-methionine (Met) than of [18F]fluoro-2-deoxyglucose ( ...
https://www.ncbi.nlm.nih.gov/pubmed/9216763?dopt=Abstract
Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic...Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic...
Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic ...
https://www.ncbi.nlm.nih.gov/pubmed/10398297?dopt=Abstract
Table 2 | [18F]-Fluoro-Deoxy-Glucose Positron Emission Tomography Scan Should Be Obtained Early in Cases of Autoimmune...Table 2 | [18F]-Fluoro-Deoxy-Glucose Positron Emission Tomography Scan Should Be Obtained Early in Cases of Autoimmune...
18F]-Fluoro-Deoxy-Glucose Positron Emission Tomography Scan Should Be Obtained Early in Cases of Autoimmune Encephalitis. Table ...
https://www.hindawi.com/journals/ad/2016/9450452/tab2/
Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death | Cancer ResearchMitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death | Cancer Research
Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death. Gang Cheng, Jacek Zielonka, ... Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. Int J Cancer 2008;123:476- ... Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death ... Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death ...
http://cancerres.aacrjournals.org/content/72/10/2634.long
Stability of 18F-deoxyglucose uptake locations within tumor during radiotherapy for NSCLC: a prospective studyStability of 18F-deoxyglucose uptake locations within tumor during radiotherapy for NSCLC: a prospective study
... Int J Radiat ... Purpose: Because individual tumors are heterogeneous, including for (18)F-deoxyglucose (FDG) uptake and, most likely, for ...
https://pubmed.ncbi.nlm.nih.gov/18234432/?dopt=Abstract
Correlation Between Various Adipokines and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro...Correlation Between Various Adipokines and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro...
Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging ... With 18F-fluoro-deoxyglucose (FDG) (18FDG-PET). This study has been completed. ...
https://clinicaltrials.gov/ct2/show/NCT01150006
Foods | Free Full-Text | A 2-Deoxyglucose-Resistant Mutant of Saccharomyces cerevisiae Shows Enhanced Maltose Fermentative...Foods | Free Full-Text | A 2-Deoxyglucose-Resistant Mutant of Saccharomyces cerevisiae Shows Enhanced Maltose Fermentative...
Saccharomyces cerevisiae MCD4 is a 2-deoxyglucose (2-DOG)-resistant mutant derived from the wild-type strain, AK46, wherein the ... A 2-Deoxyglucose-Resistant Mutant of Saccharomyces cerevisiae Shows Enhanced Maltose Fermentative Ability by the Activation of ... "A 2-Deoxyglucose-Resistant Mutant of Saccharomyces cerevisiae Shows Enhanced Maltose Fermentative Ability by the Activation of ... Saccharomyces cerevisiae MCD4 is a 2-deoxyglucose (2-DOG)-resistant mutant derived from the wild-type strain, AK46, wherein the ...
https://www.mdpi.com/2304-8158/7/4/52
Sequence Similarity - 1OFN: Purification, crystallisation and preliminary structural studies of dTDP-4-keto-6-deoxy...Sequence Similarity - 1OFN: Purification, crystallisation and preliminary structural studies of dTDP-4-keto-6-deoxy...
Purification, crystallisation and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from ...
http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1OFN
Radiotherapy Planning Based on Positron Emission Tomography With Fluoro-deoxyglucose For Advanced NSCLCRadiotherapy Planning Based on Positron Emission Tomography With Fluoro-deoxyglucose For Advanced NSCLC
Simultaneous radio-chemotherapy in advanced non-small cell lung cancer. The study focusses on a randomised comparison of conventional radiotherapy plann
http://www.knowcancer.com/cancer-trials/NCT00697333/
Abstract C156: PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose. | Molecular Cancer TherapeuticsAbstract C156: PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose. | Molecular Cancer Therapeutics
Abstract C156: PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose.. Sui-Seng Tee, Jae Mo Park and ... Introduction: This study proposes the use 2-deoxyglucose (2DG) with the PKM2 activator, TEPP46 as a novel drug combination for ... PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose. [abstract]. In: Proceedings of the AACR-NCI- ... Abstract C156: PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose. ...
http://mct.aacrjournals.org/content/12/11_Supplement/C156
Mutations That Confer Resistance to 2-Deoxyglucose Reduce the Specific Activity of Hexokinase from Myxococcus xanthus | Journal...Mutations That Confer Resistance to 2-Deoxyglucose Reduce the Specific Activity of Hexokinase from Myxococcus xanthus | Journal...
Mutations That Confer Resistance to 2-Deoxyglucose Reduce the Specific Activity of Hexokinase from Myxococcus xanthus Philip ... 1977) Resistance to 2-deoxyglucose in yeast: a direct selection of mutants lacking glucose-phosphorylating enzymes. Mol. Gen. ... M. xanthus is sensitive to the antibiotic 2-deoxyglucose (2dGlc). In most organisms, the analog 2dGlc is transported by ... The glucose analog 2-deoxyglucose (2dGlc) inhibits the growth and multicellular development of Myxococcus xanthus. Mutants ofM ...
https://jb.asm.org/content/181/7/2225
5-Aminoimidazole-4-Carboxamide 1-β-d-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men |...5-Aminoimidazole-4-Carboxamide 1-β-d-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men |...
where 2DGU is deoxyglucose uptake, DG is the concentration of 2-deoxyglucose, DG6P is the concentration of 2-deoxyglucose 6- ... We studied 29 healthy men (aged 26 ± 8 years, BMI 25 ± 4 kg/m2 [mean ± SD]). Rates of muscle 2-deoxyglucose (2DG) uptake were ... To determine whether there was a linear increase in the muscle concentration of 2DG and 2-deoxyglucose 6-phosphate (2DG6P) ... Hansen PA, Gulve EA, Holloszy JO: Suitability of 2-deoxyglucose for in vitro measurement of glucose transport activity in ...
https://diabetes.diabetesjournals.org/content/56/8/2078
Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats | Endocrinology and...Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats | Endocrinology and...
Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats. K. Meszaros, G. J. Bagby ... Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats. K. Meszaros, G. J. Bagby ... The accumulation of phosphorylated 2-deoxyglucose (2DGP) was increased in skeletal muscles by 56-102% and in diaphragm by 236% ... Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats ...
http://ajpendo.physiology.org/content/253/1/E33
2-Deoxyglucose Fluorometric Assay Kit Kit-0004 - Creative BioMart2-Deoxyglucose Fluorometric Assay Kit Kit-0004 - Creative BioMart
2-Deoxyglucose Fluorometric Assay Kit can be used for research. ... 1 ml2-Deoxyglucose (2-DG, 10 mM). Cap code: purple. 1 ml2-DG ... Purified 2-Deoxyglucose Fluorometric Assay Kit from Creative Biomart. ... 2-Deoxyglucose Assay Kit (Fluorometric) is a quantitative fluorometric determination of 2-deoxyglucose.. ... 2-Deoxyglucose Fluorometric Assay Kit. Download Datasheet See All 2DG Related Kits Bring this labeled protein directly to your ...
https://www.creativebiomart.net/2-deoxyglucose-fluorometric-assay-kit-462221.htm
2-amino-2-deoxyglucose sulfate | definition of 2-amino-2-deoxyglucose sulfate by Medical dictionary2-amino-2-deoxyglucose sulfate | definition of 2-amino-2-deoxyglucose sulfate by Medical dictionary
2-amino-2-deoxyglucose sulfate explanation free. What is 2-amino-2-deoxyglucose sulfate? Meaning of 2-amino-2-deoxyglucose ... Looking for online definition of 2-amino-2-deoxyglucose sulfate in the Medical Dictionary? ... redirected from 2-amino-2-deoxyglucose sulfate). Also found in: Dictionary, Thesaurus, Encyclopedia. glucosamine. [gloo-ko´-sah ... n 2-amino-2-deoxyglucose in chitin, mucopolysaccharides, and mucoproteins. Used with chondroitin for osteoarthritis. Not for ...
https://medical-dictionary.thefreedictionary.com/2-amino-2-deoxyglucose+sulfate
The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2...The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2...
An evolutionarily conserved family of phosphatases enables cells to resist the toxic metabolic effects of 2-deoxyglucose. ... An evolutionarily conserved family of phosphatases enables cells to resist the toxic metabolic effects of 2-deoxyglucose. ... induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose ... induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose ...
https://stke.sciencemag.org/content/12/597/eaaw8000/tab-figures-data
A nonradioisotope, enzymatic assay for 2-deoxyglucose uptake in L6 skeletal muscle cells cultured in a 96-well microplate. |...A nonradioisotope, enzymatic assay for 2-deoxyglucose uptake in L6 skeletal muscle cells cultured in a 96-well microplate. |...
2-Deoxyglucose (2DG) was detected by measuring a potent fluorophore, resorufin, generated after incubation with a single assay ... A nonradioisotope, enzymatic assay for 2-deoxyglucose uptake in L6 skeletal muscle cells cultured in a 96-well microplate.. [ ...
https://www.sigmaaldrich.com/catalog/papers/16442489
Legionella pneumophila Is Directly Sensitive to 2-Deoxyglucose-Phosphate via Its UhpC Transporter but Is Indifferent to Shifts...Legionella pneumophila Is Directly Sensitive to 2-Deoxyglucose-Phosphate via Its UhpC Transporter but Is Indifferent to Shifts...
Treatment with 2-deoxyglucose (2DG) blocks L. pneumophila replication in mammalian macrophages but has no effect on bacteria ... Legionella pneumophila Is Directly Sensitive to 2-Deoxyglucose-Phosphate via Its UhpC Transporter but Is Indifferent to Shifts ... Legionella pneumophila is directly sensitive to 2-deoxyglucose-phosphate via its UhpC transporter but is indifferent to shifts ... Legionella pneumophila Is Directly Sensitive to 2-Deoxyglucose-Phosphate via Its UhpC Transporter but Is Indifferent to Shifts ...
https://jb.asm.org/content/200/16/e00176-18?ijkey=042c83e419159a7220d1e42f9e59c9d54b981298&keytype2=tf_ipsecsha
The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2...The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2...
The expression of a specific 2-deoxyglucose-6P phosphatase prevents catabolite repression mediated by 2-deoxyglucose in yeast. ... 2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 78, 1392-1399 (2006 ... Effect of 2-deoxyglucose on cell wall formation in Saccharomyces cerevisiae and its relation to cell growth inhibition. J. ... Lysis of yeast cell walls induced by 2-deoxyglucose at their sites of glucan synthesis. J. Bacteriol. 95, 1169-1172 (1968).. ...
https://stke.sciencemag.org/content/12/597/eaaw8000.full
Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. | StrokeGlycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. | Stroke
Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat.. D J ... Because 2-deoxyglucose (2-DG) is a competitive inhibitor of glycolysis we tested its ability to reduce hyperglycemia- ... Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. ... Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. ...
http://stroke.ahajournals.org/content/17/5/989
Plus itPlus it
2-Deoxy-glucose (2DG), a mimetic of glucose cannot undergo further glycolysis and hampers cell growth, essential during tumor ... 2-Deoxy-glucose synergizes with Cisplatin and Pemetrexed chemotherapeutics to reduce cell migration of mesothelioma cells. ... 2-Deoxy-glucose synergizes with Cisplatin and Pemetrexed chemotherapeutics to reduce cell migration of mesothelioma cells ... 2-Deoxy-glucose synergizes with Cisplatin and Pemetrexed chemotherapeutics to reduce cell migration of mesothelioma cells ...
https://erj.ersjournals.com/content/54/suppl_63/PA3099
Enzymatic Conversion of Glucose to UDP-4-Keto-6-Deoxyglucose in Streptomyces spp | Applied and Environmental MicrobiologyEnzymatic Conversion of Glucose to UDP-4-Keto-6-Deoxyglucose in Streptomyces spp | Applied and Environmental Microbiology
Enzymatic Conversion of Glucose to UDP-4-Keto-6-Deoxyglucose in Streptomyces spp. Song Yu Liu, John P. N. Rosazza ... Enzymatic Conversion of Glucose to UDP-4-Keto-6-Deoxyglucose in Streptomyces spp ... Enzymatic Conversion of Glucose to UDP-4-Keto-6-Deoxyglucose in Streptomyces spp ... Enzymatic Conversion of Glucose to UDP-4-Keto-6-Deoxyglucose in Streptomyces spp ...
https://aem.asm.org/content/64/10/3972/article-info
UptakePositronGlycolysisFluoro-2-deoxyglucoseInhibition by 2-deoxyglucosePhosphorylationAccumulationTumor cellsGlycolytic inhibitorRatsAnalogHexokinaseVitroPhosphataseAutoradiographyAbstractGrowth inhibitionMetabolismMetabolicSaccharomycesQuantitativeFermentationCellsNeuronsEmissionAssayMutantsInhibitoryRabbitsTherapeuticInsulinAcetateAminoYeastEffectsMacrophagesCancer
Uptake29
  • Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. (ahajournals.org)
  • 03). Glucose utilization was estimated by the uptake of [3H]deoxyglucose after its intravenous administration (2 microCi/100 g body wt) to instrumented awake animals. (ahajournals.org)
  • To correlate the abnormalities on computed tomography, magnetic resonance imaging, and bone scan with fluorinated deoxyglucose positron emission tomography (FDG-PET) in patients with progressive metastatic prostate cancer, using a lesion-by-lesion analysis, and to preliminarily explore post-treatment changes in standard uptake value (SUV) with changes in prostate-specific antigen (PSA). (nih.gov)
  • Because individual tumors are heterogeneous, including for (18)F-deoxyglucose (FDG) uptake and, most likely, for radioresistance, selective boosting of high FDG uptake zones within the tumor has been suggested. (nih.gov)
  • Rates of muscle 2-deoxyglucose (2DG) uptake were determined by measuring accumulation of total muscle 2DG (2DG and 2DG-6-phosphate) during a primed, continuous 2DG infusion. (diabetesjournals.org)
  • In rat muscle AICAR increases 2-deoxyglucose (2DG) uptake because of an effect on transport rather than metabolism ( 14 ). (diabetesjournals.org)
  • Among many different methods available for measuring glucose uptake, 2-deoxyglucose (2-DG) has been widely used because of its structural similarity to glucose. (creativebiomart.net)
  • A nonradioisotope, enzymatic assay for 2-deoxyglucose uptake in L6 skeletal muscle cells cultured in a 96-well microplate. (sigmaaldrich.com)
  • 2-D-Deoxyglucose (2-dGlc) uptake and accumulation into rat peritoneal macrophages was increased by colony-stimulating factor (mCSF) by stimulating the coupling between endofacial hexokinase activity and the sugar transporter. (portlandpress.com)
  • Exposure of differentiated L6 myotubes to the CB1 antagonist rimonabant (SR141716) selectively increased 2-deoxyglucose uptake (2-DG) in a time- and dose-dependent manner. (aspetjournals.org)
  • Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart. (semanticscholar.org)
  • Skeletal muscle glucose uptake (R(g)) in perfused hindlimbs was estimated from the uptake and subsequent phosphorylation of radiolabeled 2-deoxyglucose (2DG) in the gastrocnemius (GN), extensor digitorum longus (EDL), and soleus (SOL) muscles. (elsevier.com)
  • Glucose uptake rate, as determined by 31 P-nuclear magnetic resonance spectroscopy measuring 2-deoxyglucose conversion to 2-deoxyglucose-6-phosphate, was measured in isolated perfused hearts obtained from banded rabbits when M/V ratio had increased by 15% from baseline (compensated hypertrophy) and by 30% from baseline (early-decompensated hypertrophy). (ahajournals.org)
  • Significance of incidental focal uptake in prostate on 18-fluoro-2-deoxyglucose positron emission tomography CT images. (koreascience.or.kr)
  • Is further evaluation needed for incidental focal uptake in the prostate in 18-fluoro-2-deoxyglucose positron emission tomographycomputed tomography images? (koreascience.or.kr)
  • The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. (cdc.gov)
  • Regions of increased ( 14 C) 2-deoxyglucose (2DG) uptake were mapped autoradiographically in cerebellum. (elsevier.com)
  • DESCRIPTION (provided by applicant): A new fluorescent analogue of d-glucose, 2-[N-(7-nitrobenz-2-oxa-1,3-diaxol-4-yl)amino]-2- deoxyglucose (2-NBDG), was recently developed, but has not been characterized as a marker of glucose uptake in cancer cells. (sbir.gov)
  • The extent of ischemic and hibernating myocardium, which may be detected by increased postexercise uptake of fluoro-18 deoxyglucose (FDG) using positron emission tomography, may determine the degree of functional benefit after revascularization. (edu.au)
  • We examined the effects of μ-opioid receptor agonist and antagonists, and κ-opioid receptor agonist on the hypoxia/hypoglycemia-induced reduction in 2-deoxyglucose uptake of rat hippocampal slices. (elsevier.com)
  • Chronic administration of morphine (10 mg/kg) for 9 days affected neither the basal nor the hypoxia/hypoglycemia-induced reduction in 2-deoxyglucose uptake. (elsevier.com)
  • Shibata, S , Tominaga, K & Watanabe, S 1995, ' κ-Opioid receptor agonist protects against ischemic reduction of 2-deoxyglucose uptake in morphine-tolerant rats ', European Journal of Pharmacology , vol. 279, no. 2-3, pp. 197-202. (elsevier.com)
  • Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and rn" by J Rosen, J Fina et al. (jax.org)
  • Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and rna and protein metabolism in lymphosarcoma p1798. (jax.org)
  • To investigate the prevalence and clinical significance of incidental prostate fluoro-2-deoxyglucose (FDG) uptake and to evaluate its impact on patient management. (bvsalud.org)
  • Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate. (ox.ac.uk)
  • We have demonstrated that rat hippocampal slices exposed to oxygen/glucose-free medium showed decreases in 2-deoxyglucose (2-DG) uptake and CA1 field potentials elicited by the stimulation of Schaffer collaterals. (elsevier.com)
  • This study investigated whether changing a tumor's oxygenation would alter tumor metabolism, and thus uptake of 18 F-FDG (fluorine-18 deoxyglucose), a marker for glucose metabolism using positron emission tomography (PET). (springer.com)
  • The aims were to determine if the maximum standardized uptake value (SUV(max)) of the primary tumor as determined by preoperative (18)F-fluoro-2-deoxyglucose ((18)F-FDG) positron emission tomography (PET) is an independent predictor of overall survival and to assess its prognostic value after stratification according to pathological staging. (qxmd.com)
Positron10
  • Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging technique to identify the inflammatory state of atherosclerotic plaque. (clinicaltrials.gov)
  • Early assessment with 18F-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography to predict short-term outcome in clear cell renal carcinoma treated with nivolumab. (urotoday.com)
  • We reported previously the usefulness of 18F-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to predict prognosis of renal cell carcinoma (RCC) treated with molecular targeted agents. (urotoday.com)
  • We report six demented individuals with pathologically verified diffuse Lewy body disease (DLBD) studied with fluoro-deoxyglucose positron emission tomography (FDG-PET). (neurology.org)
  • MATERIALS AND METHODS: Thirty-six lesions identified on noncontrast MR in 35 patients with biopsy-proved intracranial tumors were imaged with both T1-weighted Cd-DTPA MR at 1.5 T and [ 18 F]2-fiuoro-2-deoxyglucose (FDG) positron emission tomography (PET). (elsevier.com)
  • 18-fluoro-2-deoxyglucose positron emission tomography-computed tomography ( $^{18}F$ -FDG PET/CT) scans are commonly used for the staging and restaging of various malignancies, such as head and neck, breast, colorectal and gynecological cancers. (koreascience.or.kr)
  • Metabolic imaging of untreated prostate cancer by positron emission tomography with 18fluorine-labeled deoxyglucose. (koreascience.or.kr)
  • 18 F-FDG (fluorine-18 deoxyglucose) has become widely used as a radiolabeled marker for positron emission tomography (PET) imaging of solid tumors. (springer.com)
  • PURPOSE: [18F]-Fluoro-d-deoxyglucose positron emission tomography (FDG-PET) is an expensive, invasive, and not widely available technique used in the presurgical evaluation of temporal lobe epilepsy. (tue.nl)
  • Moons, K.G.M. / The added value of [18F]-fluoro-D-deoxyglucose positron emission tomography in screening for temporal lobe epilepsy surgery . (tue.nl)
Glycolysis10
  • 2-Deoxyglucose (2DG), an inhibitor of glycolysis, abrogates seizure activity and retards epilepsy progression both in vitro and in vivo . (frontiersin.org)
  • Previous studies demonstrated that a glycolysis inhibitor, 2-deoxyglucose (2DG), blocks replication of L. pneumophila during infection of macrophages, leading to speculation that L. pneumophila may exploit macrophage glycolysis. (asm.org)
  • Once imported into cells and phosphorylated, the glucose analog 2-deoxyglucose (2DG) inhibits glycolysis, leading to the proposal of using 2DG as a cancer treatment. (sciencemag.org)
  • The glucose analog 2-deoxyglucose (2DG) is imported into cells and, after phosphorylation, becomes 2DG-6-phosphate, a toxic by-product that inhibits glycolysis. (sciencemag.org)
  • Because 2-deoxyglucose (2-DG) is a competitive inhibitor of glycolysis we tested its ability to reduce hyperglycemia-exacerbated ischemic brain damage. (ahajournals.org)
  • This study investigated the preclinical efficacy of targeting the tumor bioenergetic pathway using a glycolysis inhibitor 2-deoxyglucose (2DG) and AMPK agonists, AICAR and metformin. (aacrjournals.org)
  • Herein, we describe the functional outcomes of glycolysis inhibition by 2-deoxyglucose (2DG) in combination with AMPK agonists, AICAR and metformin. (aacrjournals.org)
  • Therefore, the glucose analog 2-deoxyglucose (2DG) has been used as an anticancer reagent due to its inhibition of glycolysis. (altmetric.com)
  • A marked age-dependent response was observed with 2-deoxyglucose but not with antimycin A. The results confirm an increase in the rate of glycolysis with ageing, which appears to be independent of cellular mitochondrial respiratory chain capacity. (semanticscholar.org)
  • Moreover, we show that treatment with 2-deoxyglucose, a well known inhibitor of glycolysis, inhibits BCSC proliferation when used alone and shows a synergic effect when used in combination with doxorubicin. (unipa.it)
Fluoro-2-deoxyglucose3
  • PET for diagnosis of malignant lymphoma of the scalp: comparison of [11C]methyl-L-methionine and [18F]fluoro-2-deoxyglucose. (nih.gov)
  • PET demonstrated more intensive and wider accumulation of [11C]methyl-L-methionine (Met) than of [18F]fluoro-2-deoxyglucose (FDG). (nih.gov)
  • We investigated the potential of predicting allograft rejection by measuring the ability of graft-infiltrating cells to take up 2-[18F]fluoro-2-deoxyglucose ([18F]FDG). (ovid.com)
Inhibition by 2-deoxyglucose2
  • Abstract C156: PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose. (aacrjournals.org)
  • Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat. (ahajournals.org)
Phosphorylation1
  • Effect of 2-deoxyglucose phosphorylation on phosphorus metabolism. (jax.org)
Accumulation1
  • The accumulation of phosphorylated 2-deoxyglucose (2DGP) was increased in skeletal muscles by 56-102% and in diaphragm by 236% at 3 h after treatment with 100 micrograms/100 g endotoxin. (physiology.org)
Tumor cells1
  • Inhibition of the glycolytic pathway with 2-deoxyglucose leads to sensitization of tumor cells to other apoptotic stimuli(Maschek, G., et al Cancer Res. (aacrjournals.org)
Glycolytic inhibitor3
  • Here, we discuss the evidence for one glycolytic inhibitor, 2-deoxyglucose (2DG) and one metabolic substrate, β-hydroxybutyrate (BHB) exerting direct effects on neuronal excitability, highlight their mechanistic differences, and provide the strengthening scientific rationale for their individual or possibly combined use in the clinical arena of seizure management. (frontiersin.org)
  • 2-Deoxyglucose (2-DG), a glycolytic inhibitor analog of glucose, is widely investigated in experimental and clinical oncology for targeting glucose metabolism. (aacrjournals.org)
  • Our lead compound, developed at the National Institute on Aging, was 2-deoxyglucose, an analogue of the native sugar, that acted as a glycolytic inhibitor, having limited metabolism and actually reducing overall energy flow--analogous to CR. (isharonline.org)
Rats1
  • This benchmark article described for the first time the theory and procedure of the quantitative autoradiographic [14C] deoxyglucose method for the quantitative determination of local glucose utilization in the nervous system and the values obtained with it in normal and anesthetized rats. (nih.gov)
Analog1
  • The glucose analog 2-deoxyglucose (2dGlc) inhibits the growth and multicellular development of Myxococcus xanthus . (asm.org)
Hexokinase2
  • Expression of the Escherichia coli glk (glucokinase) gene in M. xanthus hex mutants restores 2dGlc sensitivity, suggesting that these mutants arise upon the loss of a soluble hexokinase function that phosphorylates 2dGlc to form the toxic intermediate, 2-deoxyglucose-6-phosphate. (asm.org)
  • 2-Deoxyglucose (2DG) was detected by measuring a potent fluorophore, resorufin, generated after incubation with a single assay solution containing hexokinase, adenosine 5'-triphosphate, glucose 6-phosphate dehydrogenase, beta-nicotineamide adenine dinucleotide phosphate, diaphorase, and resazurin. (sigmaaldrich.com)
Vitro2
  • Differential growth inhibition of human diploid fibroblasts by 2-deoxyglucose and antimycin A with ageing in vitro. (semanticscholar.org)
  • The relative growth inhibitory effects of 2-deoxyglucose and antimycin A were monitored at five stages during the life-span in vitro of human diploid fibroblasts. (semanticscholar.org)
Phosphatase2
  • In enzymology, a 2-deoxyglucose-6-phosphatase (EC 3.1.3.68) is an enzyme that catalyzes the chemical reaction 2-deoxy-D-glucose 6-phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } 2-deoxy-D-glucose + phosphate Thus, the two substrates of this enzyme are 2-deoxy-D-glucose 6-phosphate and H2O, whereas its two products are 2-deoxy-D-glucose and phosphate. (wikipedia.org)
  • This enzyme is also called 2-deoxyglucose-6-phosphate phosphatase. (wikipedia.org)
Autoradiography2
  • 14)C]2-deoxyglucose (2-DG) autoradiography was combined with T(2)(*) OC to determine metabolic status of T(2)(*)-defined penumbra. (sinapse.ac.uk)
  • Additionally, domains sharing the ocular dominance and orientation preference of the neurons at the injection sites were visualized by 2-deoxyglucose (2-DG) autoradiography. (jneurosci.org)
Abstract1
  • abstract = "Radiolabeled deoxyglucose (FDG) has been advocated as a marker of viability of reperfused myocardium during acute infarction. (elsevier.com)
Growth inhibition1
  • 1971. Effect of 2-deoxyglucose on cell wall formation in Saccharomyces cerevisiae and its relation to cell growth inhibition. (exeley.com)
Metabolism3
  • CONCLUSIONS: Deoxyglucose-induced metabolism inhibition increased the PAP ventilated with 21% O2, but it didn't increase the PAP ventilated with 3% O2. (koreamed.org)
  • Previously, we reported that under normal O 2 conditions (21% O 2 ), the dual glucose metabolism inhibitor 2-deoxyglucose (2-DG) activates a cytoprotective autophagic response in cancer cells mainly through the induction of endoplasmic reticulum (ER) stress rather than ATP 2 reduction. (elsevier.com)
  • Cerebral blood flow (CBF) rises when the glucose supply to the brain is limited by hypoglycemia or glucose metabolism is inhibited by pharmacological doses of 2-deoxyglucose (DG). (elsevier.com)
Metabolic1
  • 1. We have studied the effects of the metabolic inhibitors cyanide (CN) and deoxyglucose (DG) on the intracellular Ca2+ concentration ([Ca2+]i) in macrovascular endothelial cells derived from human umbilical vein (EA cells). (kuleuven.be)
Saccharomyces1
  • Saccharomyces cerevisiae MCD4 is a 2-deoxyglucose (2-DOG)-resistant mutant derived from the wild-type strain, AK46, wherein the 2-DOG resistance improves the maltose fermentative ability. (mdpi.com)
Quantitative1
  • 2-Deoxyglucose Assay Kit (Fluorometric) is a quantitative fluorometric determination of 2-deoxyglucose. (creativebiomart.net)
Fermentation1
  • Beta-fructofuranosidase production by 2-deoxyglucose resistant mutants of aspergillus niger in submerged and solid-state fermentation. (bvsalud.org)
Cells2
  • Schizosaccharomyces pombe cells of strains each carrying a deletion of one of the genes snf5, ypa1, pho7 and pas1 and of a strain overexpress-ing gene odr1, have been previously shown to grow in presence of the toxic glucose analogue 2-deoxyglucose (2-DG). (exeley.com)
  • Cultures of Chinese Hamster Cells (CCL 16, Don Strain) were treated with 2-Deoxyglucose over varying lengths of time in order to compare the mitotic index with the rate of adenosine triphosphate synthesis. (uni.edu)
Neurons2
  • Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parki. (nih.gov)
  • Tekkök, S & Krnjević, K 1996, ' Calcium dependence of LTP induced by 2-deoxyglucose in CA1 neurons ', Journal of neurophysiology , vol. 76, no. 4, pp. 2343-2352. (elsevier.com)
Emission1
  • A near-infrared fluorophore, IRDye 800CW, emission maximum 794 nm, was conjugated to 2-deoxyglucose (2-DG). (unl.edu)
Assay1
  • In 2-Deoxyglucose Assay Kit (Fluorometric), the accumulated 2-DG6P is enzymatically oxidized and coupled to PicoProbe, which generates fluorescence in the presence of NADPH. (creativebiomart.net)
Mutants2
  • After ultraviolet mutagenization and selection, seven derepressed mutants resistant to 2-deoxyglucose (2-DG) were isolated on Czapek's minimal medium containing glycerol. (ovid.com)
  • After UV mutagenesis of conidiospores of A. niger , 2-deoxyglucose (10 g/l) resistant mutants were isolated on Czapek's minimal medium containing glycerol as a carbon source and the mutants were examined for improved production of beta-fructofuranosidase in SmF and SSF conditions. (bvsalud.org)
Inhibitory1
  • Through adaptation in the presence of 2-deoxyglucose, we have generated Zymomonas mobilis strain #7, which is better suited to utilizing xylose in pretreated corn stover (PCS) fermentations in the presence of both glucose and model inhibitory compounds of acetate and furfural. (biomedcentral.com)
Rabbits1
  • The rates of local cerebral glucose utilization have been measured in normal conscious and hypnotized rabbits by the [14C]deoxyglucose method. (isharonline.org)
Therapeutic1
  • The effects of 2-deoxyglucose on the developing human fetus at the recommended therapeutic dose are unknown. (knowcancer.com)
Insulin1
  • 3H]Deoxyglucose plasma half-life and fasting and post-glucose load insulin levels were comparable in the two groups. (ahajournals.org)
Acetate1
  • We performed an extended lab-directed evolution of Z. mobilis strain 8b in the presence of acetate and a non-hydrolyzable glucose analogue 2-deoxyglucose. (biomedcentral.com)
Amino1
Yeast1
  • Lysis of yeast cell walls induced by 2-deoxyglucose at their sites of glucan synthesis. (exeley.com)
Effects2
  • Effects of 2-deoxyglucose on carbohydrate metablism: review of the literature and studies in the rat. (exeley.com)
  • Young, Darrell D. (1972) "The Effects of 2-Deoxyglucose on the ATP Consumption in Cell Cultures," Proceedings of the Iowa Academy of Science, 79(1), 41-43. (uni.edu)
Macrophages1
  • Treatment with 2-deoxyglucose (2DG) blocks L. pneumophila replication in mammalian macrophages but has no effect on bacteria grown in broth. (asm.org)
Cancer1
  • Introduction: This study proposes the use 2-deoxyglucose (2DG) with the PKM2 activator, TEPP46 as a novel drug combination for cancer chemotherapy. (aacrjournals.org)
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Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis | PNAS (pnas.org)
Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. | Hypertension
Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. | Hypertension (hyper.ahajournals.org)
February 1996 - Volume 21 - Issue 2 : Clinical Nuclear Medicine
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Non-Hodgkin Lymphoma Metabolism | SpringerLink (link.springer.com)
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IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity | PNAS
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PET and SPECT Imaging of Neurotoxicity | SpringerLink
PET and SPECT Imaging of Neurotoxicity | SpringerLink (link.springer.com)
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Altered Visual Experience Induces Instructive Changes of Orientation Preference in Mouse Visual Cortex | Journal of Neuroscience (jneurosci.org)
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