Dengue virus. Medical search

A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.

An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.

A virulent form of dengue characterized by THROMBOCYTOPENIA and an increase in vascular permeability (grades I and II) and distinguished by a positive pain test (e.g., TOURNIQUET PAIN TEST). When accompanied by SHOCK (grades III and IV), it is called dengue shock syndrome.

Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.

A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.

The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.

Immunoglobulins produced in response to VIRAL ANTIGENS.

Viruses whose genetic material is RNA.

The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.

Enhancement of viral infectivity caused by non-neutralizing antibodies. There are at least two mechanisms known to account for this: mediation by Fc receptors (RECEPTORS, FC) or by complement receptors (RECEPTORS, COMPLEMENT). Either the virus is complexed with antiviral IMMUNOGLOBULIN G and binds to Fc receptors, or virus is coated with antiviral IMMUNOGLOBULIN M and binds to complement receptors.

Ribonucleic acid that makes up the genetic material of viruses.

Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.

Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.

Process of growing viruses in live animals, plants, or cultured cells.

Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.

A family of the order DIPTERA that comprises the mosquitoes. The larval stages are aquatic, and the adults can be recognized by the characteristic WINGS, ANIMAL venation, the scales along the wing veins, and the long proboscis. Many species are of particular medical importance.

A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.

Substances elaborated by viruses that have antigenic activity.

A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.

A genus of FLAVIVIRIDAE containing several subgroups and many species. Most are arboviruses transmitted by mosquitoes or ticks. The type species is YELLOW FEVER VIRUS.

The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.

A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE). It can infect birds and mammals. In humans, it is seen most frequently in Africa, Asia, and Europe presenting as a silent infection or undifferentiated fever (WEST NILE FEVER). The virus appeared in North America for the first time in 1999. It is transmitted mainly by CULEX spp mosquitoes which feed primarily on birds, but it can also be carried by the Asian Tiger mosquito, AEDES albopictus, which feeds mainly on mammals.

A general term for diseases produced by viruses.

Process of determining and distinguishing species of bacteria or viruses based on antigens they share.

The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).

The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).

Established cell cultures that have the potential to propagate indefinitely.

Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.

A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.

Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.

The type species of the FLAVIVIRUS genus. Principal vector transmission to humans is by AEDES spp. mosquitoes.

Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.

Viruses parasitic on plants higher than bacteria.

The relationships of groups of organisms as reflected by their genetic makeup.

Viruses whose nucleic acid is DNA.

Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.

Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.

Proteins found in any species of virus.

The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.

The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.

A family of proteins that promote unwinding of RNA during splicing and translation.

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.

A species of ALPHAVIRUS causing an acute dengue-like fever.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

The type species of LYSSAVIRUS causing rabies in humans and other animals. Transmission is mostly by animal bites through saliva. The virus is neurotropic multiplying in neurons and myotubes of vertebrates.

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.

A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.

The presence of viruses in the blood.

The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.

The functional hereditary units of VIRUSES.

A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 3 and neuraminidase 2. The H3N2 subtype was responsible for the Hong Kong flu pandemic of 1968.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.

The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.

Infections with viruses of the genus FLAVIVIRUS, family FLAVIVIRIDAE.

The interactions between a host and a pathogen, usually resulting in disease.

A group of viruses in the PNEUMOVIRUS genus causing respiratory infections in various mammals. Humans and cattle are most affected but infections in goats and sheep have also been reported.

A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.

The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.

Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The type species of VESICULOVIRUS causing a disease symptomatically similar to FOOT-AND-MOUTH DISEASE in cattle, horses, and pigs. It may be transmitted to other species including humans, where it causes influenza-like symptoms.

Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.

The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.

Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Deoxyribonucleic acid that makes up the genetic material of viruses.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

The general name for NORTH AMERICA; CENTRAL AMERICA; and SOUTH AMERICA unspecified or combined.

Viruses that produce tumors.

Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.

The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.

Aspects of health and disease related to travel.

Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

A subgroup of the genus FLAVIVIRUS that causes encephalitis and hemorrhagic fevers and is found in eastern and western Europe and the former Soviet Union. It is transmitted by TICKS and there is an associated milk-borne transmission from viremic cattle, goats, and sheep.

Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.

A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. Transmission occurs by droplet infection.

Proteins that form the CAPSID of VIRUSES.

The outer protein protective shell of a virus, which protects the viral nucleic acid.

A species of RESPIROVIRUS also called hemadsorption virus 2 (HA2), which causes laryngotracheitis in humans, especially children.

A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), which is the etiological agent of Japanese encephalitis found in Asia, southeast Asia, and the Indian subcontinent.

Viruses which produce a mottled appearance of the leaves of plants.

Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

The complete genetic complement contained in a DNA or RNA molecule in a virus.

Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).

An island in the Greater Antilles in the West Indies. Its capital is San Juan. It is a self-governing commonwealth in union with the United States. It was discovered by Columbus in 1493 but no colonization was attempted until 1508. It belonged to Spain until ceded to the United States in 1898. It became a commonwealth with autonomy in internal affairs in 1952. Columbus named the island San Juan for St. John's Day, the Monday he arrived, and the bay Puerto Rico, rich harbor. The island became Puerto Rico officially in 1932. (From Webster's New Geographical Dictionary, 1988, p987 & Room, Brewer's Dictionary of Names, 1992, p436)

A species in the genus HEPATOVIRUS containing one serotype and two strains: HUMAN HEPATITIS A VIRUS and Simian hepatitis A virus causing hepatitis in humans (HEPATITIS A) and primates, respectively.

A species of ALPHAVIRUS isolated in central, eastern, and southern Africa.

Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.

Antibodies produced by a single clone of cells.

Sites on an antigen that interact with specific antibodies.

Group of alpharetroviruses (ALPHARETROVIRUS) producing sarcomata and other tumors in chickens and other fowl and also in pigeons, ducks, and RATS.

A species of POLYOMAVIRUS apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. The virus remains latent in the body throughout life and can be reactivated under certain circumstances.

Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.

The geographical area of Asia comprising BORNEO; BRUNEI; CAMBODIA; INDONESIA; LAOS; MALAYSIA; the MEKONG VALLEY; MYANMAR (formerly Burma), the PHILIPPINES; SINGAPORE; THAILAND; and VIETNAM.

Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.

The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.

The reduction or regulation of the population of mosquitoes through chemical, biological, or other means.

Viruses whose taxonomic relationships have not been established.

A species of POLYOMAVIRUS, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials J.C. gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus.

Inoculation of a series of animals or in vitro tissue with an infectious bacterium or virus, as in VIRULENCE studies and the development of vaccines.

The type species of ALPHARETROVIRUS producing latent or manifest lymphoid leukosis in fowl.

Arthropod-borne viruses. A non-taxonomic designation for viruses that can replicate in both vertebrate hosts and arthropod vectors. Included are some members of the following families: ARENAVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; TOGAVIRIDAE; and FLAVIVIRIDAE. (From Dictionary of Microbiology and Molecular Biology, 2nd ed)

The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.

DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)

A family of RNA viruses causing INFLUENZA and other diseases. There are five recognized genera: INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; ISAVIRUS; and THOGOTOVIRUS.

EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.

The type species of ORBIVIRUS causing a serious disease in sheep, especially lambs. It may also infect wild ruminants and other domestic animals.

Virus diseases caused by the ORTHOMYXOVIRIDAE.

Proteins found mainly in icosahedral DNA and RNA viruses. They consist of proteins directly associated with the nucleic acid inside the NUCLEOCAPSID.

Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.

The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.

Elements of limited time intervals, contributing to particular results or situations.

The type species of RESPIROVIRUS in the subfamily PARAMYXOVIRINAE. It is the murine version of HUMAN PARAINFLUENZA VIRUS 1, distinguished by host range.

A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) arising during the propagation of S37 mouse sarcoma, and causing lymphoid leukemia in mice. It also infects rats and newborn hamsters. It is apparently transmitted to embryos in utero and to newborns through mother's milk.

Inactivation of viruses by non-immune related techniques. They include extremes of pH, HEAT treatment, ultraviolet radiation, IONIZING RADIATION; DESICCATION; ANTISEPTICS; DISINFECTANTS; organic solvents, and DETERGENTS.

Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.

A collection of single-stranded RNA viruses scattered across the Bunyaviridae, Flaviviridae, and Togaviridae families whose common property is the ability to induce encephalitic conditions in infected hosts.

A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.

The type species of TOBAMOVIRUS which causes mosaic disease of tobacco. Transmission occurs by mechanical inoculation.

A mosquito-borne viral illness caused by the WEST NILE VIRUS, a FLAVIVIRUS and endemic to regions of Africa, Asia, and Europe. Common clinical features include HEADACHE; FEVER; maculopapular rash; gastrointestinal symptoms; and lymphadenopathy. MENINGITIS; ENCEPHALITIS; and MYELITIS may also occur. The disease may occasionally be fatal or leave survivors with residual neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13; Lancet 1998 Sep 5;352(9130):767-71)

The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.

Genotypic differences observed among individuals in a population.

Infections caused by arthropod-borne viruses, general or unspecified.

Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.

The type species of LEPORIPOXVIRUS causing infectious myxomatosis, a severe generalized disease, in rabbits. Tumors are not always present.

A species of ORTHOPOXVIRUS that is the etiologic agent of COWPOX. It is closely related to but antigenically different from VACCINIA VIRUS.

Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects. (1/2185)

The mosquito-borne dengue viruses are widespread human pathogens causing dengue fever, dengue hemorrhagic fever, and dengue shock syndrome, placing 40% of the world's population at risk with no effective treatment. The viral genome is a positive strand RNA that encodes a single polyprotein precursor. Processing of the polyprotein precursor into mature proteins is carried out by the host signal peptidase and by NS3 serine protease, which requires NS2B as a cofactor. We report here the crystal structure of the NS3 serine protease domain at 2.1 A resolution. This structure of the protease combined with modeling of peptide substrates into the active site suggests identities of residues involved in substrate recognition as well as providing a structural basis for several mutational effects on enzyme activity. This structure will be useful for development of specific inhibitors as therapeutics against dengue and other flaviviral proteases. (+info)

Variation in oral susceptibility to dengue type 2 virus of populations of Aedes aegypti from the islands of Tahiti and Moorea, French Polynesia. (2/2185)

Twenty three samples of Aedes aegypti populations from the islands of Tahiti and Moorea (French Polynesia) were tested for their oral susceptibility to dengue type 2 virus. The high infection rates obtained suggest that the artificial feeding protocol used was more efficient than those previously described. Statistical analysis of the results allowed us to define two distinct geographic areas on Tahiti with respect to the susceptibility of Ae. aegypti: the east coast, with homogeneous infection rates, and the west coast, with heterogeneous infection rates. No geographic differences could be demonstrated on Moorea. The possible mechanisms of this phenomenon are discussed in connection with recent findings on the variability of susceptibility of Ae. aegypti to insecticides. (+info)

Replication of dengue type 2 virus in Culex quinquefasciatus (Diptera: Culicidae). (3/2185)

We were able to infect Culex quinquefasciatus by the parenteral route with dengue virus type 2. The percentage of mosquitoes infected was dose dependent and we obtained a rate of 45.6% infected Cx. quinquefasciatus when a 10(5.9) MID50 (mosquito infectious dose for 50% of the individuals as measured in Aedes aegypti) of dengue virus type 2 per mosquito was used. Infection was detected by an immunofluorescent assay performed on mosquito head squashes 14 days after infection. The replication of dengue virus in Cx. quinquefasciatus was either at a very low level of magnitude or generated a large number of noninfectious particles since the triturated bodies of infected Cx. quinquefasciatus did not infect Ae. aegypti mosquitoes when inoculated parenterally. We were unable to infect Cx. quinquefasciatus females orally with an artificial meal that infected 100% of Ae. aegypti females. These findings lead us to agree with the consensus that Cx. quinquefasciatus should not be considered a biological vector of dengue viruses. (+info)

Bacterial lipopolysaccharide inhibits dengue virus infection of primary human monocytes/macrophages by blockade of virus entry via a CD14-dependent mechanism. (4/2185)

Monocytes/macrophages (MO/Mphi) are the major target cells for both dengue virus (DV) and bacterial lipopolysaccharide (LPS), and the aim of this study was to define their interactions. We had found that LPS markedly suppressed DV infection of primary human MO/Mphi when it was added to cultures prior to or together with, but not after, viral adsorption. The inhibitory effect of LPS was direct and specific and was not mediated by LPS-induced secretion of cytokines and chemokines such as tumor necrosis factor alpha, interleukin-1beta (IL-1beta), IL-6, IL-8, IL-12, alpha interferon, MIP-1alpha, and RANTES. In fact, productive DV infection was not blocked but was just postponed by LPS, with a time lag equal to one viral replication cycle. Time course studies demonstrated that LPS was only effective in suppressing DV infection of MO/Mphi that had not been previously exposed to the virus. At various time points after viral adsorption, the level of unbound viruses that remained free in the culture supernatants of LPS-pretreated cultures was much higher than that of untreated controls. These observations suggest that the LPS-induced suppression of DV replication was at the level of virus attachment and/or entry. Blockade of the major LPS receptor, CD14, with monoclonal antibodies MY4 or MoS39 failed to inhibit DV infection but could totally abrogate the inhibitory effect of LPS. Moreover, human serum could significantly enhance the LPS-induced DV suppression in a CD14-dependent manner, indicating that the "binding" of LPS to CD14 was critical for the induction of virus inhibition. Taken together, our results suggest that LPS blocked DV entry into human MO/Mphi via its receptor CD14 and that a CD14-associated cell surface structure may be essential for the initiation of a DV infection. (+info)

The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids. (5/2185)

NS3 protein of dengue virus type 2 has a serine protease domain within the N-terminal 180 residues. NS2B is required for NS3 to form an active protease involved in processing of the viral polyprotein precursor. The region carboxy terminal to the protease domain has conserved motifs present in several viral RNA-stimulated nucleoside triphosphatase (NTPase)/RNA helicases. To define the functional domains of protease and NTPase/RNA helicase activities of NS3, full-length and amino-terminal deletion mutants of NS3 were expressed in Escherichia coli and purified. Deletion of 160 N-terminal residues of NS3 (as in NS3del.2) had no detrimental effect on the basal and RNA-stimulated NTPase as well as RNA helicase activities. However, mutagenesis of the conserved P-loop motif of the RNA helicase domain (K199E) resulted in loss of ATPase activity. The RNA-stimulated NTPase activity was significantly affected by deletion of 20 amino acid residues from the N terminus or by substitutions of the cluster of basic residues, 184RKRK-->QNGN, of NS3del.2, although both mutant proteins retained the conserved RNA helicase motifs. Furthermore, the minimal NS3 protease domain, required for cleavage of the 2B-3 site, was precisely defined to be 167 residues, using the in vitro processing of NS2B-NS3 precursors. Our results reveal that the functional domains required for serine protease and RNA-stimulated NTPase activities map within the region between amino acid residues 160 and 180 of NS3 protein and that a novel motif, the cluster of basic residues 184RKRK, plays an important role for the RNA-stimulated NTPase activity. (+info)

Effects of dengue fever during pregnancy in French Guiana. (6/2185)

To determine the effects of dengue fever (DF) during pregnancy, pregnant women presenting with a dengue-like syndrome at a hospital in Saint-Laurent du Maroni, French Guiana, from 1 January 1992 to 1 April 1998 were studied. The diagnosis of DF was made by serological tests, virus isolation on AP 61 mosquito cells, and/or reverse transcriptase polymerase chain reaction analysis. Twenty-two women had either probable or confirmed DF. Dengue virus serotype 2 was detected in four cases, and dengue virus serotype 1 was detected in one. Three fetuses died following the onset of the disease, and three cases of prematurity occurred. All infants appeared normal during physical examination, and no neonatal DF was diagnosed. In conclusion, DF in pregnant women did not cause any infant abnormality, but it may have been responsible for fetal death. The rate of fetal death associated with DF (13.6%) was much higher than the mean rate for the gynecology unit at the hospital (1.9%). However, these differences were not significant, and consequently these preliminary results need to be confirmed. (+info)

Bystander target cell lysis and cytokine production by dengue virus-specific human CD4(+) cytotoxic T-lymphocyte clones. (7/2185)

Dengue hemorrhagic fever, the severe form of dengue virus infection, is believed to be an immunopathological response to a secondary infection with a heterologous serotype of dengue virus. Dengue virus capsid protein-specific CD4(+) cytotoxic T-lymphocyte (CTL) clones were shown to be capable of mediating bystander lysis of non-antigen-presenting target cells. After activation by anti-CD3 or in the presence of unlabeled antigen-presenting target cells, these clones could lyse both Jurkat cells and HepG2 cells as bystander targets. Lysis of HepG2 cells suggests a potential role for CD4(+) CTL in the liver involvement observed during dengue virus infection. Three CD4(+) CTL clones were demonstrated to lyse cognate, antigen-presenting target cells by a mechanism that primarily involves perforin, while bystander lysis occurred through Fas/Fas ligand interactions. In contrast, one clone used a Fas/Fas ligand mechanism to lyse both cognate and bystander targets. Cytokine production by the CTL clones was also examined. In response to stimulation with D2 antigen, CD4(+) T-cell clones produced gamma interferon, tumor necrosis factor alpha (TNF-alpha) and TNF-beta. The data suggest that CD4(+) CTL clones may contribute to the immunopathology observed upon secondary dengue virus infections through direct cytolysis and/or cytokine production. (+info)

Evaluation of the MRL diagnostics dengue fever virus IgM capture ELISA and the PanBio Rapid Immunochromatographic Test for diagnosis of dengue fever in Jamaica. (8/2185)

We evaluated two new commercial dengue diagnostic tests, the MRL Diagnostics Dengue Fever Virus IgM Capture ELISA and the PanBio Rapid Immunochromatographic Test, on serum samples collected during a dengue epidemic in Jamaica. The MRL ELISA method correctly identified 98% (78 of 80) of the samples as dengue positive, while the PanBio test identified 100% (80 of 80). Both tests were 100% (20 samples of 20) specific. (+info)

... (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family ... Scholia has a topic profile for Dengue virus. 3D electron microscopy structures of dengue virus from the EM Data Bank(EMDB) " ... especially dengue virus, has the ability to inhibit the innate immune response during the infection. Indeed, dengue virus has ... Comparative evolutionary epidemiology of dengue virus serotypes. Infect Genet Evol 12(2):309-314 "Dengue virus". Pathogen ...

https://en.wikipedia.org/wiki/Dengue_virus

Yauch, Lauren E. (2014). "Dengue Virus Vaccine Development". Advances in Virus Research. 88: 315-372. doi:10.1016/B978-0-12- ... Dengue vaccine is a vaccine used to prevent dengue fever in humans. Development of dengue vaccines began in the 1920s, but was ... dengue viruses which replicate locally and elicit humoral and cellular immune responses against the four dengue virus serotypes ... dengue vaccine. Some of the children who received the vaccine had never been infected by the dengue virus before. The program ...

https://en.wikipedia.org/wiki/Dengue_vaccine

West Nile virus, Zika virus, St. Louis encephalitis virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kyasanur ... The 1997 classification divided dengue into an undifferentiated fever, dengue fever, and dengue hemorrhagic fever. Dengue ... Dengue fever virus (DENV) is an RNA virus of the family Flaviviridae; genus Flavivirus. Other members of the same genus include ... Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days ...

https://en.wikipedia.org/wiki/Dengue_fever

The Dengue pandemic in Sri Lanka is part of the tropical disease Dengue fever pandemic. Dengue fever caused by Dengue virus. ... Sirisena, P.D.N.N.; Noordeen, F. (2014-02-01). "Evolution of dengue in Sri Lanka-changes in the virus, vector, and climate". ... From 1989 onward, Dengue fever has become endemic in Sri Lanka. Dengue outbreak start Sri Lanka since 1960s, Ministry of Health ... In 1990 dengue cases rise 1,350 of54 deaths. Early 90s, annually dengue cases reported up to 1,000. In 2002 recorded the ...

https://en.wikipedia.org/wiki/Dengue_pandemic_in_Sri_Lanka

American visitors to and visitors from dengue-endemic regions will continue to present a potential pathway for the dengue virus ... Dengue Fever Hits Paraguay Reuters, "Dengue Fever Hits Paraguay", New York Times" (March 4, 2007)] "Dengue Fever Outbreak ... dengue.asp?CodSeccion=25[dead link] "cme-fk-uii-2010-kaji-virus-dengue - lintas.me". Lintasberita.com. 2010-07-14. Archived ... "First dengue virus seroprevalence study on Madeira Island after the 2012 outbreak indicates unreported dengue circulation". ...

https://en.wikipedia.org/wiki/Dengue_fever_outbreaks

... yellow fever virus, dengue virus and Pappataci fever virus. More than 100 of such viruses are now known to cause human diseases ... There are numerous causes, including viruses - particularly hepatitis A virus, hepatitis B virus and hepatitis C virus. ... As of 2010, dengue virus is the most prevalent arbovirus and increasingly virulent strains of the virus have spread across Asia ... Breitbart M, Rohwer F (2005). "Here a virus, there a virus, everywhere the same virus?". Trends in Microbiology. 13 (6): 278- ...

https://en.wikipedia.org/wiki/Social_history_of_viruses

... dengue virus, and yellow fever virus. The virus is primarily transmitted by mosquitoes, mostly species of Culex. The primary ... Carro, Ana C.; Damonte, Elsa B. (2013). "Requirement of cholesterol in the viral envelope for dengue virus infection". Virus ... "Dengue Viruses". www.nature.com. Retrieved 2017-12-19. Colpitts, Tonya M.; Conway, Michael J.; Montgomery, Ruth R.; Fikrig, ... together with Japanese encephalitis virus, Murray Valley encephalitis virus, Saint Louis encephalitis virus and some other ...

https://en.wikipedia.org/wiki/West_Nile_virus

Dengue fever becomes the second disease shown to be caused by a virus. October 21 - Jaw of Homo heidelbergensis (Mauer 1) found ... Henchal, Erik A.; Putnak, J. Robert (October 1990). "The Dengue Viruses". Clinical Microbiology Reviews. American Society for ...

https://en.wikipedia.org/wiki/1907_in_science

Dengue virus group Dengue virus Japanese encephalitis virus group Japanese encephalitis virus Murray Valley encephalitis virus ... Louis encephalitis virus West Nile virus Spondweni virus group Spondweni virus Zika virus Yellow fever virus group Yellow fever ... virus Tick-borne viruses Mammalian tick-borne virus group Kyasanur forest disease virus Tick-borne encephalitis virus Family ... virus Bluetongue disease virus Epizootic hemorrhagic disease virus Equine encephalosis virus Genus Seadornavirus Banna virus ...

https://en.wikipedia.org/wiki/Arbovirus

"Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by ... Murthy claimed 1BEF could be used as a potential treatment option for patients with dengue and other flaviviral proteases. The ... These papers covered a range of topics; everything from dengue to Taq DNA polymerase. The UAB investigation turned up ...

https://en.wikipedia.org/wiki/H.M._Krishna_Murthy

Zika Virus and Dengue Virus); first aid training; and sanitation improvement. Community engagement is strongly pushed, and ...

https://en.wikipedia.org/wiki/Dominican_Red_Cross

Chan, Miranda; Johansson, Michael A. (Nov 30, 2012). "The Incubation Periods of Dengue Viruses". PLOS ONE. 7 (11): e50972. ... Gubler, D. J. (1998). "Dengue and dengue hemorrhagic fever". Clinical Microbiology Reviews. 11 (3): 480-96. doi:10.1128/CMR. ... This is in contrast to viral latency, a form of dormancy in which the virus does not replicate. An example of latency is HIV ... Erythema Infectiosum at eMedicine Kahn, James O.; Walker, Bruce D. (1998). "Acute Human Immunodeficiency Virus Type 1 Infection ...

https://en.wikipedia.org/wiki/Incubation_period

It is used extensively in hepatitis C and dengue virus research. Huh7 cells have been instrumental in hepatitis C research. ... "The medicinal chemistry of dengue virus". Journal of Medicinal Chemistry. 59 (12): 5622-5649. doi:10.1021/acs.jmedchem.5b01653 ... The introduction of the Huh7 cell line permitted screening of drug candidates against laboratory-cultured hepatitis C virus and ... Bartenschlager, R; Pietschmann, T (2005). "Efficient hepatitis C virus cell culture system: what a difference the host cell ...

https://en.wikipedia.org/wiki/Huh7

... s are also the initial target of the virus that causes dengue fever during its development. During ageing the ... Martina BE, Koraka P, Osterhaus AD (October 2009). "Dengue virus pathogenesis: an integrated view". Clinical Microbiology ... Fausch, Steven C.; Da Silva, Diane M.; Rudolf, Michael P.; Kast, W. Martin (2002-09-15). "Human papillomavirus virus-like ... High-risk human papillomaviruses (HPV) are sexually transmitted viruses causally associated with several cancers including ...

https://en.wikipedia.org/wiki/Langerhans_cell

The tropical flaviviral infections dengue fever and Zika virus have also been associated with episodes of GBS. Previous ... Two other herpes viruses (Epstein-Barr virus/HHV-4 and varicella zoster virus/HHV-3) and the bacterium Mycoplasma pneumoniae ... Carod-Artal FJ, Wichmann O, Farrar J, Gascón J (September 2013). "Neurological complications of dengue virus infection". The ... The 2009 flu pandemic vaccine against pandemic swine flu virus H1N1/PDM09 did not cause a significant increase in cases. In ...

https://en.wikipedia.org/wiki/Guillain–Barré_syndrome

"Dengue Virus Reveals Its Circular Secret". ScienceDaily. May 27, 2016. Retrieved May 27, 2016. "Discover the 2016 L'Oréal- ... She received a 2016 L'Oréal-UNESCO Awards for Women in Science fellowship for work on mosquito-borne viruses include Dengue ... Andrea Gamarnik (born 1964) is an Argentinian molecular virologist noted for her work on Dengue fever. ...

https://en.wikipedia.org/wiki/Andrea_Gamarnik

Lim, K. A., Chan, Y. C., Phoon, W. O., & Hanam, E. (1964). Dengue-type viruses isolated in Singapore. Bulletin of the World ... As a microbiologist at the University of Malaya, Lim was the first to isolate the specific virus (Influenza A/Singapore/1/57) ... Hermes (19 April 2020). "The man who isolated Asian flu virus with help of eggs , The Straits Times". www.straitstimes.com. ... LIM, K A; BENYESH-MELNICK, M (1 March 1960). "Typing of viruses by combinations of antiserum pools. Application to typing of ...

https://en.wikipedia.org/wiki/Lim_Kok_Ann

While endothelial cells are not the major cell type Dengue targets, the virus binds to various cell surface receptors on ... The virus can also target the epithelium of the mucus membranes of these organ systems. Virus particles tend to exit from the ... Once the virus is anchored to the cell surface, virus uptake typically occurs using host mechanisms such as endocytosis. One ... Basu, Atanu; Chaturvedi, Umesh C. (August 2008). "Vascular endothelium: the battlefield of dengue viruses". FEMS Immunology & ...

https://en.wikipedia.org/wiki/Endothelial_cell_tropism

December 2009). "An adenosine nucleoside inhibitor of dengue virus". Proceedings of the National Academy of Sciences of the ... West Nile virus, yellow fever virus, Powassan virus, hepatitis C virus, Kyasanur Forest disease virus, Omsk hemorrhagic fever ... for flavivirus infections and shows broad spectrum antiviral activity against many related viruses such as dengue virus, ... virus, and Zika virus. However, NITD008 proved too toxic in pre-clinical animal testing to be suitable for human trials, but it ...

https://en.wikipedia.org/wiki/NITD008

December 2009). "An adenosine nucleoside inhibitor of dengue virus". Proceedings of the National Academy of Sciences of the ... The 7-deaza-adenosine analog has been shown to inhibit the replication of the hepatitis C virus. BCX4430 is protective against ... adenosine analog NITD008 has been reported to directly inhibit the recombinant RNA-dependent RNA polymerase of the dengue virus ... October 2004). "A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent ...

https://en.wikipedia.org/wiki/Adenosine

... severe fever thrombocytopenia syndrome virus, influenza virus, dengue virus (DNV) and Zika virus than control mice, which ... November 2010). "Mouse STAT2 restricts early dengue virus replication". Cell Host & Microbe. 8 (5): 410-21. doi:10.1016/j.chom. ... March 2017). "A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory ... The virus infection was treated by high-dose of intravenous immunoglobulin (IVIG) after which patients recovered and became ...

https://en.wikipedia.org/wiki/STAT2

Yellow fever viruses, Dengue fever viruses, and Zika viruses are of the Flavivirus genera and Chikungunya virus is of the ... Dengue fever: The Dengue virus is a flavivirus also transmissible by Aedes mosquito vectors to other animal hosts. Dengue was ... were found with antibodies dengue viruses 1 and 2 while sloths (Bradypus torquatus) had antibodies for dengue virus 3 therefore ... A 2009 study in French Guiana found that infections of dengue viruses types 1 through 4 were present in various different types ...

https://en.wikipedia.org/wiki/Reverse_zoonosis

In April 2016, Figueroa contracted dengue virus. He was isolated at home to avoid contagion, before returning to training with ... "Alarma en el Fortín: Un jugador de Vélez tiene dengue". Nuevo Diario. 5 April 2016. Retrieved 20 May 2019. "El renovado Vélez ... "Figueroa, el arquero de Vélez, padece dengue". ESPN. 5 April 2016. Retrieved 20 May 2019. "El tercer arquero de Vélez fue ... arquero del plantel de Vélez tiene dengue". TyC Sports. 5 April 2016. Retrieved 20 May 2019. " ...

https://en.wikipedia.org/wiki/Tomás_Figueroa

There are 50-100 million dengue virus infections annually. Dengue fever is usually not fatal, but infection with one of four ... The virus was first isolated from an outbreak in Tanzania in 1952. Chikungunya virus is a member of the genus Alphavirus and ... No treatment for either dengue or severe dengue exists beyond palliative care. The symptoms are high fever and flu-like ... viruses (dengue and chikungunya, rabies).[citation needed] The World Health Organization recognizes the twenty diseases below ...

https://en.wikipedia.org/wiki/Neglected_tropical_diseases

Finally, lipid droplets are known to be exploited by pathogens such as the hepatitis C virus, the dengue virus and Chlamydia ... Heaton, N.S.; Randall, G (2010). "Dengue virus-induced autophagy regulates lipid metabolism". Cell Host Microbe. 8 (5): 422-32 ...

https://en.wikipedia.org/wiki/Lipid_droplet

"Inhibition of interferon signaling by dengue virus". Proceedings of the National Academy of Sciences. 100 (24): 14333-14338. ... "Vaccination of Pigs against Swine Influenza Viruses by Using an NS1-Truncated Modified Live-Virus Vaccine". Journal of Virology ... "An enzymatic virus-like particle assay for sensitive detection of virus entry". Journal of Virological Methods. 163 (2): 336- ... "Inhibition of Interferon-Mediated Antiviral Responses by Influenza a Viruses and Other Negative-Strand RNA Viruses". Virology. ...

https://en.wikipedia.org/wiki/Adolfo_García-Sastre

There are four strains of dengue virus, DENV-1 to DENV-4. Infection with one serotype confers immunity against it, but not the ... A locally uncommon strain of the dengue virus - one that the local populace would be more susceptible to - had begun to ... In the 2020 dengue outbreak in Singapore, a record-breaking number of dengue fever cases was reported in Singapore. This was ... "Dengue Cases Expected To Exceed Last Year's 16,000 Cases Unless All Stakeholders Take Immediate Concerted Action Against Dengue ...

https://en.wikipedia.org/wiki/2020_dengue_outbreak_in_Singapore

"Laboratory-Acquired Dengue Virus Infection-A Case Report". PLOS Neglected Tropical Diseases. Journals.plos.org. 5 (11): e1324. ... "Laboratory-acquired dengue virus infection by needlestick injury: a case report, South Korea, 2014". Annals of Occupational and ... Emond, R T; Evans, B; Bowen, E T; Lloyd, G (27 August 1977). "A case of Ebola virus infection". British Medical Journal. 2 ( ... Helen Regan (2019-09-17). "Explosion and fire break out at Russian lab known for housing deadly smallpox virus". CNN. Retrieved ...

https://en.wikipedia.org/wiki/List_of_laboratory_biosecurity_incidents

The genus includes human pathogens like Zika virus, West-Nile virus, Dengue virus, Yellow Fever virus and other. The 5' UTR of ... is a critical determinant of dengue virus and West Nile virus RNA synthesis". Virology. 379 (2): 314-323. doi:10.1016/j.virol. ... "Functional RNA Elements in the Dengue Virus Genome". Viruses. 3 (9): 1739-1756. doi:10.3390/v3091739. ISSN 1999-4915. PMC ... Filomatori, C. V. (2006-08-15). "A 5' RNA element promotes dengue virus RNA synthesis on a circular genome". Genes & ...

https://en.wikipedia.org/wiki/Flavivirus_5'_UTR

The genus includes human pathogens like Zika virus, West-Nile virus, Dengue virus, Yellow Fever virus and other. The 3' UTR ... Romero, T. A.; Tumban, E.; Jun, J.; Lott, W. B.; Hanley, K. A. (2006-11-01). "Secondary structure of dengue virus type 4 3' ... Mutations of sHP are shown to be lethal for Dengue virus in mosquito cells. CRE is highly involved in the 5'-3' UTR interaction ... "Dengue Virus RNA Structure Specialization Facilitates Host Adaptation". PLOS Pathogens. 11 (1): e1004604. doi:10.1371/journal. ...

https://en.wikipedia.org/wiki/Flavivirus_3'_UTR

She has led the country through Middle East respiratory syndrome (MERS), Influenza A virus subtype H7N9 (bird flu) and Dengue ... Her first frontline experience with infectious diseases were when the Nipah virus infected Singapore in 1999. In 2002 Leo was ... "A breakout star in battle against virus outbreaks". AsiaOne. Retrieved 1 December 2020. "Why Singapore will overcome Covid-19 ... Ang, Prisca (25 January 2020). "Wuhan virus: Masks necessary only for those with respiratory symptoms, stresses chief of ...

https://en.wikipedia.org/wiki/Yee-Sin_Leo

... parainfluenza virus, influenza virus, dengue virus, and West Nile virus. Subbarao K, McAuliffe J... Murphy B (2004). Prior ... 11563-11567 Subbarao EK, London W, Murphy BR (1993). A single amino acid in the PB2 gene of influenza A virus is a determinant ... "The Influenza Viruses and their Vaccines - Seminar Notice". NIH Clinical Center. Retrieved 18 July 2019. Alexander C. Schmidt, ... et al, Respiratory syncytial virus and other pneumoviruses: a review of the international symposium-RSV 2003, Virus Research ...

https://en.wikipedia.org/wiki/Brian_R._Murphy

Zika Virus Zika virus infection has been linked to an increase in microcephaly in infants and Guillain-Barre syndrome (a ... Zika is a member of the Flaviviridae family, which includes medically important pathogens such as dengue fever, yellow fever, ... GeoVax technology approach uses recombinant DNA or recombinant viruses to produce virus-like particles (VLPs) in the person ... The MVA expresses the HIV virus-like-particles, but does not express GM-CSF. The regimen builds on the GeoVax DNA/MVA vaccine ...

https://en.wikipedia.org/wiki/GeoVax

Viruses that inhibit IFN signaling include Japanese Encephalitis Virus (JEV), dengue type 2 virus (DEN-2), and viruses of the ... Some viruses escape the anti-viral activities of interferons by gene (and thus protein) mutation. The H5N1 influenza virus, ... Some viruses can encode proteins that bind to double-stranded RNA (dsRNA) to prevent the activity of RNA-dependent protein ... A virus-infected cell releases viral particles that can infect nearby cells. However, the infected cell can protect neighboring ...

https://en.wikipedia.org/wiki/Interferon

Differential diagnosis includes dengue, leptospirosis, chikungunya, and Zika fever. Appropriate antibiotic treatment should be ... the organism smaller than a bacterium and larger than a virus) that causes this disease. He and others characterized the basic ...

https://en.wikipedia.org/wiki/Rocky_Mountain_spotted_fever

Studying ways of preventing or treating diseases caused by respiratory syncytial virus (RSV), herpes simplex virus, and dengue ... Developing vaccine strategies for Ebola, HIV, Lassa virus, West Nile virus, Japanese encephalitis viruses, and herpes. ... Developing an animal model to test vaccines to protect people against the Zika virus. On April 14, 2018, four baboons escaped ... Helped advance a new treatment which moved from animal to human trials for chronic hepatitis B virus (HBV) infection. ...

https://en.wikipedia.org/wiki/Texas_Biomedical_Research_Institute

Yellow fever Dengue fever Ilhéus virus Venezuelan equine encephalitis virus St. Louis virus Mayaro virus* Oropouche virus* ... and new insights into the epidemiology of key virus diseases including yellow fever, dengue fever, and rabies. Downs headed a ... Tacaribe virus* (isolated in 1956 from a bat) Virus Diseases in the West Indies - a special edition of the Caribbean Medical ... The Trinidad Regional Virus Laboratory (T.R.V.L.) was established in Port of Spain, in 1953 by the Rockefeller Foundation in co ...

https://en.wikipedia.org/wiki/Trinidad_Regional_Virus_Laboratory

RID insect repellents are used to repel insects which may carry a number of diseases, including Ross River virus, dengue fever ... West Nile virus, malaria, yellow fever, Japanese B encephalitis, filariasis, Lyme disease, leishmaniasis, typhus fever, plague ...

https://en.wikipedia.org/wiki/RID_(insect_repellent)

... illness with this virus has ranged from mild to severe with fatalities reported; as of 6 June 2022, Mexico has reported a total ... dengue fever note: a new coronavirus is causing sustained community spread of respiratory illness (COVID-19) in Mexico; ... sustained community spread means that people have been infected with the virus, but how or where they became infected is not ...

https://en.wikipedia.org/wiki/Demographics_of_Mexico

For her doctoral work, Corbett worked in Sri Lanka to study the role of human antibodies in dengue virus pathogenesis. While in ... From 2009 to 2014, Corbett studied human antibody responses to dengue virus in Sri Lankan children under the supervision of ... Corbett, Kizzmekia Shanta (August 2014). Characterization of Human Antibody Responses to Dengue Virus Infections in a Sri ... Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and ...

https://en.wikipedia.org/wiki/Kizzmekia_Corbett

Sippy R, Herrera D, Gaus D, Gangnon R, Osorio J, and Patz J. Seasonality of Dengue Fever in Rural Ecuador: 2009-2016. PLOS NTDs ... "Satellite imagery characteristics local animal reservoir populations of Sin Monbre virus in the southwestern United States." ... altered mosquito-borne malaria and dengue fever risks from projected climate change; and increased malaria risk from combined ...

https://en.wikipedia.org/wiki/Jonathan_Patz

The flu virus is officially designated by the WHO as "Influenza A (H1N1)", following a name change from "swine flu" to avoid ... He was given antiviral drugs and antibiotics and he was also tested for tuberculosis, typhoid, dengue, Leptospirosis and H1N1 ... Since the Nipah virus outbreak in 1999, the Malaysian Health Ministry have put in place processes to be better prepared to ... He was then had a seizure and was sent to Tengku Ampuan Afzan Hospital and confirmed to have the H1N1 virus. He died on 7 ...

https://en.wikipedia.org/wiki/2009_swine_flu_pandemic_in_Malaysia

West Nile virus, dengue fever and yellow fever. While mosquitoes, more specifically the Aedes aegypti species, serve as the ... Infection by RNA viruses can trigger the RNAi cascade. It is likely dicer is involved in viral immunity as viruses that infect ... Similarly to humans, insect viruses have evolved mechanisms to avoid the RNAi pathway. As an example, Drosophila C virus ... In humans, the viruses HIV-1, influenza, and vaccinia encode such RNAi suppressing proteins. Inhibition of dicer is beneficial ...

https://en.wikipedia.org/wiki/Dicer

"A Taste For Pork Helped A Deadly Virus Jump To Humans". NPR.org. "Nipah virus at 20". www.virology.ws. "QS Ranking".{{cite web ... "Ipoh medical student awarded prestigious Rhodes Scholarship, hopes to eradicate dengue one day , Malay Mail". www.malaymail.com ... The faculty is well-known for its medical education and research, especially in the discovery of the Nipah virus (1998-1999 ... Nipah Virus Encephalitis Investigation Team from the Faculty of Medicine, University of Malaya In 2020, Subashan Vadibeler, a ...

https://en.wikipedia.org/wiki/Faculty_of_Medicine,_University_of_Malaya

He also studied the transmission of dengue virus by the mosquito Stegomyia fasciata (Aedes aegypti). John Burton Cleland was ...

https://en.wikipedia.org/wiki/John_Burton_Cleland

Dengue virus induces PERK dependent ER stress as part of virus induced response in infected cells to favor replication. ... March 2016). "Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway ... Influenza virus requires endoplasmic reticulum protein 57-kD (ERp57) for replication and apoptosis induction in infected cells ... "Heavy chain binding protein recognizes incompletely disulfide-bonded forms of vesicular stomatitis virus G protein". The ...

https://en.wikipedia.org/wiki/Unfolded_protein_response

Three serotypes of Phlebovirus are known as the causative agents: Naples virus, Sicilian virus and Toscana virus.[citation ... Sabin A.B. (1955). "Recent advances in our knowledge of dengue and sandfly fever". American Journal of Tropical Medicine and ... Besides this horizontal virus transmission from man to sandfly, the virus can be transmitted in insects transovarially, from an ...

https://en.wikipedia.org/wiki/Pappataci_fever

"Guatemala Bans Arrivals From U.S., Canada to Fight Corona-virus". U.S. News. 13 March 2020. Retrieved 15 March 2020. " ... Cocoliztli epidemics 1889-1890 flu pandemic 1918-20 Spanish flu pandemic 1968 Hong Kong flu pandemic HIV/AIDS 2019-2020 dengue ... The virus was confirmed to have reached Guatemala in March 2020. On 12 January 2020, the World Health Organization (WHO) ... in an effort to tackle the COVID-19 pandemic and prevent the spreading of the virus.[citation needed] On April 23, the United ...

https://en.wikipedia.org/wiki/COVID-19_pandemic_in_Guatemala

"Analysis of RNA Binding by the Dengue Virus NS5 RNA Capping Enzyme." PLoS ONE 6.10 (2011): n. pag. Web. 12 Dec. 2015. Kading, R ... Viruses that are associated with Entebbe Bat Virus are Sokolul Virus and Yokose Virus. Both of those viruses are categorized ... 2015). Entebbe bat virus is a (+) single-stranded RNA (ssRNA) genome virus. It is an enveloped virus with icosahedral ... the virus is very similar to the Yellow Fever Virus. Since Entebbe Bat Virus is in the Genus Flavivirus, the structure is ...

https://en.wikipedia.org/wiki/Entebbe_bat_virus

The most known ligand for CLEC5A is dengue virus (DV). Activated CLEC5A by binding to the dengue virion leads to ... CLEC5A is responsible for dengue virus induced hemorrhagic fever (DHF) and dengue shock syndrome (DSS), which is the most ... Interaction of CLEC5A and dengue virus also induces osteolytic activity. Another pathogen is influenza virus and its ... In the case of dengue virus, monoclonal anti-CLEC5A antibodies are able to suppress the secretion of proinflammatory cytokines ...

https://en.wikipedia.org/wiki/CLEC5A

Theiler, Max and Downs, W. G. The Arthropod-Borne Viruses of Vertebrates: An Account of the Rockefeller Foundation Virus ... dengue fever, leprosy, filariasis, scrub typhus, leprosy, intestinal parasites, fungal infections, tuberculosis, and more.[ ... "Virus Diseases in the West Indies." Special Edition of the Caribbean Medical Journal, Vol. XXVI, Nos. 1-4, 1965. Cook, Joan (20 ... In 1969 he worked on isolating the Lassa fever virus with Jordi Casals-Ariet and Sonja Buckley. He resigned from the ...

https://en.wikipedia.org/wiki/Wilbur_Downs

The dengue virus also inhibits type I IFN production by blocking IRF-3 phosophorylation using NS2B3 protease complex. Bacteria ... Some viruses evade this by producing molecules that interfere with IFN production. For example, the Influenza A virus produces ... "Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active ... Rather, NK cells destroy compromised host cells, such as tumor cells or virus-infected cells, recognizing such cells by a ...

https://en.wikipedia.org/wiki/Innate_immune_system

"CEPI awards contract worth up to US$ 31 million to The University of Tokyo to develop vaccine against Nipah virus". CEPI. 25 ... dengue fever, and leishmaniasis. It has supported the testing and development of 40 different vaccine formulations that have ... "The quest for an effective vaccine against Zika virus infection". Community Research and Development Information Service ( ...

https://en.wikipedia.org/wiki/European_Vaccine_Initiative

Rash on hand and feet of a 36-year-old man Rash on the soles of a child's feet The viruses that cause the disease are of the ... The disease may be a new variant of the viral HFMD or an effect of chikungunya or dengue fever. Flu may be a misnomer. The ... The viruses that cause HFMD are spread through close personal contact, through the air from coughing and the feces of an ... Signs and symptoms normally appear 3-6 days after exposure to the virus. The rash generally resolves on its own in about a week ...

https://en.wikipedia.org/wiki/Hand,_foot,_and_mouth_disease

She seems to have passed on the virus to her neighbour. Two weeks later, Duarte Province confirmed number of cases are only ... of disease in the Caribbean HIV/AIDS in Latin America 2013-2014 chikungunya outbreak 2009 swine flu pandemic 2019-2020 dengue ... The chancellor of the Dominican Republic, Miguel Vargas Maldonado would have contracted the virus from his son, who attended ... Twenty Dominican doctors were exposed to the virus while celebrating their 30-year medical school graduation anniversary on ...

https://en.wikipedia.org/wiki/COVID-19_pandemic_in_the_Dominican_Republic

Viscerotropic leishmaniasis Wheat warehouse itch Virus-related cutaneous conditions are caused by two main groups of viruses- ... Butcher's wart Chikungunya fever Condylomata acuminata Congenital rubella syndrome Cowpox Cytomegalic inclusion disease Dengue ... Alphavirus infection Asymmetric periflexural exanthem of childhood (unilateral laterothoracic exanthem) B virus infection ... viruses, or parasites. Bacterium-related cutaneous conditions often have distinct morphologic characteristics that may be an ...

https://en.wikipedia.org/wiki/List_of_skin_conditions

... a Dengue-Endemic City". PLOS Neglected Tropical Diseases. 10 (11): e0005129. doi:10.1371/journal.pntd.0005129. ISSN 1935-2735. ... Influenza and Other Respiratory Viruses. 15 (5): 678-687. doi:10.1111/irv.12843. PMC 8404057. PMID 33586871. Austin, Latoya T ...

https://en.wikipedia.org/wiki/Health_belief_model

CRISPR can be used to target the virus or the host to disrupt genes encoding the virus cell-surface receptor proteins. In ... This technique has further implications in eradicating other vector borne diseases such as yellow fever, dengue, and Zika. The ... Antiviral applications for therapies targeting human viruses such as HIV, herpes, and hepatitis B virus are under research. ... The agents that are competent to edit genetic codes are viruses or subviral RNA-agents. Although GEEN has higher efficiency ...

https://en.wikipedia.org/wiki/Genome_editing

... for pathogenetic study of human diseases including malaria and dengue fever. It is therefore proposed that blood and tissue ... J, McKee; N, Clark; F, Shapter; G, Simmons (April 2017). "A New Look at the Origins of Gibbon Ape Leukemia Virus". Virus Genes ... "Gibbon ape leukemia virus-Hall's Island: new strain of gibbon ape leukemia virus". Journal of Virology. 29 (1): 395-400. doi: ... Viruses. 11 (6): 503. doi:10.3390/v11060503. ISSN 1999-4915. PMC 6630418. PMID 31159230. "Feline Leukemia Virus". Cornell ...

https://en.wikipedia.org/wiki/Gibbon_ape_leukemia_virus

Information for healthcare providers about determining the likelihood of dengue virus infection. ... Dengue Vaccineplus icon*For Healthcare Providers: A Dengue Vaccine Can Protect Your Patientsplus icon*Vaccine Eligibility & ... For Parents: A Safe and Effective Vaccine to Prevent Dengue Is Now Availableplus icon*Who Can Get a Dengue Vaccine & Whenplus ... to determine the likelihood that the current or recent illness is due to an infection with dengue virus. ...

https://www.cdc.gov/dengue/healthcare-providers/testing/index.html

Virus Sections. Virus Name/Prototype. Original Source. Method of Isolation. Virus Properties. Antigenic Relationship. Biologic ... Classical dengue with rash after appropriate incubation in first and subsequent volunteers and Ae aegypti transmission.** ... Click on the PDF icon to the left to view a copy of this virus entry in PDF format. You can get a copy of the PDF viewer by ...

https://wwwn.cdc.gov/ArboCAT/VirusDetails.aspx?ID=129&SID=3

The generation of autoimmunity in dengue virus (‎DEN)‎ infection has been implicated in dengue pathogenesis. Based on our ... 2004)‎. Autoimmunity in dengue virus infection.. WHO Regional Office for South-East Asia. https://apps.who.int/iris/handle/ ... Dengue haemorrhagic fever (‎DHF)‎ is a complicated disease associated with viral and immune pathogenesis. There is still no ... The results suggest that autoimmune responses are implicated in dengue disease pathogenesis and cause concern in vaccine ...

https://apps.who.int/iris/handle/10665/163993

2005)‎. Mammalian dengue virus receptors. WHO Regional Office for South-East Asia. https://extranet.who.int/iris/restricted/ ...

https://extranet.who.int/iris/restricted/handle/10665/164026?locale-attribute=en&

Dengue and Dengue Hemorrhagic Fever Dengue and Dengue Hemorrhagic Fever. Dengue Type 3 Virus, Saint Martin, 2003-2004 ... The year of dengue virus type 3 subtype III detection is indicated under the concerned island or country. The upper map is a ...

https://wwwnc.cdc.gov/eid/article/11/5/04-0959-f1.htm

Dengue virus (DENV), an emerging mosquito-transmitted pathogen capable of causing severe disease in humans, interacts with host ... A physical interaction network of dengue virus and human proteins Mol Cell Proteomics. 2011 Dec;10(12):M111.012187. doi: ... Dengue virus (DENV), an emerging mosquito-transmitted pathogen capable of causing severe disease in humans, interacts with host ... including six previously implicated in DENV infection and 45 linked to the replication of other viruses. Human proteins with ...

https://pubmed.ncbi.nlm.nih.gov/21911577/

... is working on the first weapon to fight the most common mosquito-borne virus. ... Roche began tests on a drug initially developed for hepatitis C in July to see if it works on dengue fever, which was carried ... Roche expects to know within months if the pill, balapiravir, may give it a head start in the hunt for a treatment for dengue, ... is working on the first weapon to fight the most common mosquito-borne virus. ...

https://www.bloomberg.com/news/articles/2010-10-26/break-bone-fever-draws-roche-drug-as-dengue-virus-hits-riviera

... which was caused by the mosquito-borne dengue virus infection, according to a report of her case published today. ... Dengue virus was detected in a biopsy of her bone marrow.. Dengue virus infects an estimated 400 million people worldwide each ... The 63-year-old woman was only the third person in the United States in the past 10 years to become infected by dengue virus ... A woman in Texas who died in 2012 succumbed to a rare blood cell disease, which was caused by the mosquito-borne dengue virus ...

https://www.livescience.com/42800-rare-fatal-disease-hlh-by-dengue.html

... the transmission of the virus can be significantly reduced. Read more at straitstimes.com. ... Beware deadly dengue virus lurking in homes Check often to eradicate mosquito breeding spots, as dengue is on the rise this ... dengue.. So far, it has killed 12 people - or half the number who have died from the other virus, Sars-CoV-2, which causes ... with the headline Beware deadly dengue virus lurking in homes. Subscribe ...

https://www.straitstimes.com/opinion/beware-the-deadly-virus-lurking-in-our-homes

Multiplex polymerase chain reaction-based serotype analysis of dengue virus during 2015 dengue outbreak in Pakistan ... Dengue is caused by dengue virus complex, which consists of 4 antigenically and immunogenically distinct serotypes, DENV1, ... So, NS1 antigen positivity is a good surrogate marker of dengue virus viremia because NS1 antigen is expressed by all 4 dengue ... Analyse des sérotypes du virus de la dengue par amplification en chaîne par polymérase multiplexe pendant la flambée de dengue ...

http://www.emro.who.int/fr/emhj-volume-23-2017/volume-23-issue-9/multiplex-polymerase-chain-reaction-based-serotype-analysis-of-dengue-virus-during-2015-dengue-outbreak-in-pakistan.html

WHO advises Dengvaxia be used only in people previously infected with dengue ... WHO Recommends Sanofis Dengue Vaccine Only For People Previously Infected With Virus. Dec 14, 2017 ... of vaccine recipients but it should not be administered to people who have not previously been infected with dengue virus. This ... World Health Organization: WHO advises Dengvaxia be used only in people previously infected with dengue. "Following a ...

https://www.kff.org/news-summary/who-recommends-sanofis-dengue-vaccine-only-for-people-previously-infected-with-virus/

Scientists create a new strain of mosquito they say could help in the fight against viruses such as dengue fever and perhaps ... If no dengue virus makes it to the salivary glands of the mosquito, the insect cannot pass the virus on to humans. ... Studies on dengue have shown that when a mosquito bites an infected person, the ability of the virus to spread throughout the ... Scientists have created a new strain of mosquito they say could help in the fight against viruses such as dengue fever and ...

https://www.abc.net.au/news/science/2016-02-19/superinfected-mosquitoes-to-fight-dengue-zika-viruses/7180960?topic=tech

... *Khyber Pakhtunkhwa reports 107 new cases of mosquito-borne disease in ... Punjab reports 459 new dengue cases. With dengue continuing to wreak havoc in the country, 459 cases were reported in Punjab ... So far this year, 6,727 confirmed cases of dengue have been reported across the province, while 4,874 confirmed cases of dengue ... Meanwhile, another patient suffering from dengue succumbed to the disease in Rawalpindi on Sunday, taking the dengue death toll ...

https://www.geo.tv/latest/376563-islamabad-sees-141-new-cases-of-dengue-virus-overnight

... strong Dengue IgG reactive and IgM reactive tested by lateral flow device. ... Recombinant Dengue Virus Subtype 2 Envelope 45kDa Suitable for Gold Conjugation, ... Recombinant Dengue Virus Subtype 2 Envelope (a.a 43-413) migrates at 45kDa, produced in E.coli, this protein is fused to 6xHis ... Dengue fever is affected by 1 of 4 closely linked virus serotypes of the genus Flavivirus, family Flaviviridae. One might have ...

https://www.prospecbio.com/dengue_envelope-2_45kda

The authors investigate the variety and depth of available models for dengue fever surveillance and their use as early warning ...

https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0001648

Dengue haemorrhagic fever and dengue shock syndrome, the most severe responses to dengue virus (DV) infection, are ... Here we show that CLEC5A interacts with the dengue virion directly and thereby brings about DAP12 phosphorylation. The CLEC5A- ... for alleviating tissue damage and increasing the survival of patients suffering from d Dengue haemorrhagic fever and dengue ... for alleviating tissue damage and increasing the survival of patients suffering from dengue haemorrhagic fever and dengue shock ...

https://www.semanticscholar.org/paper/CLEC5A-is-critical-for-dengue-virus-induced-lethal-Chen-Lin/17654f790d0dace756dd660adc92943ef1289c18

Effects of Pathogen-Vector Interactions on the Transmission of Dengue Virus. From MicrobeWiki, the student-edited microbiology ... are Aedes innate immune system response to viral infection and vector immune response to co-infection of dengue virus and the ... Figure ?. Amount of virus (in plaque forming units) from the midguts of mosquitoes raised with (septic) or without microbial ... the gut of mosquitoes also influences the Toll pathway response and has an overlapping immune response that affect dengue virus ...

https://microbewiki.kenyon.edu/index.php?title=Effects_of_Pathogen-Vector_Interactions_on_the_Transmission_of_Dengue_Virus&oldid=56393

Comparison of dengue virus type 2 from a patient returning from Abidjan, Côte dIvoire, to Japan (arrow) with reference dengue ... Dengue Virus Exported from Côte dIvoire to Japan, June 2017 Tetsuya Suzuki, Satoshi Kutsuna. , Satoshi Taniguchi, Shigeru ... Dengue Virus Exported from Côte dIvoire to Japan, June 2017. ... Virus lineages are shown on right. Phylogenetic trees were ...

https://wwwnc.cdc.gov/eid/article/23/10/17-1132-f1

Dengue has been found in native mosquitos and at least one human, suggesting that it could be spreading locally in the state ... The Dengue Virus Has Been Found in Arizona. Dengue has been found in native mosquitos and at least one human, suggesting that ... Many experts fear that climate change will allow dengue and similar viruses to become a local problem in previously unaffected ... In fact, it actually raises the risk of severe dengue should you ever catch another type of the virus. ...

https://gizmodo.com/dengue-virus-arizona-mosquitoes-1849795810

Brazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting a continuous struggle with effective control and ... Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil Publication. Date: 16th April ...

https://nanoporetech.com/resource-centre/field-and-classroom-initiatives-portable-sequence-based-monitoring-dengue-virus

Access Dengue Virus Infections case definitions; uniform criteria used to define a disease for public health surveillance. ... Dengue Virus Infections , 2015 Case Definition. *Dengue Virus Infections , 2010 Case Definition ... Dengue Virus Infections , 1996 Case Definition. *Dengue Virus Infections , 1990 Case Definition ...

https://ndc.services.cdc.gov/conditions/dengue-virus-infections/

Aiding in the diagnosis of dengue virus infection ... Dengue Virus Ab, IgG, S. No Yes. DENM. Dengue Virus Ab, IgM, S ... Detection of antibodies to dengue virus is suggestive of recent exposure and/or infection with dengue virus.. ... The presence of IgG-class antibodies to dengue virus (DV) is consistent with exposure to this virus sometime in the past. By 3 ... Dengue virus IgG:. In this ELISA assay, controls and diluted samples are incubated in microtiter wells coated with monoclonal ...

https://www.mayocliniclabs.com/test-catalog/overview/83865

Dengue is a potentially fatal acute febrile illness caused by the mosquito-borne dengue viruses (DENV-1 to -4). To estimate ... Adv Virus Res 53: 35-70. Gubler. DJ. Meltzer. M. , 1999. . Impact of dengue/dengue hemorrhagic fever on the developing world. ... Adv Virus Res 53: 35-70. Gubler. DJ. Meltzer. M. , 1999. . Impact of dengue/dengue hemorrhagic fever on the developing world. ... The reappearance of dengue-3 and a subsequent dengue-4 and dengue-1 epidemic in Puerto Rico in 1998. Am J Trop Med Hyg 67: 355- ...

https://www.ajtmh.org/view/journals/tpmd/92/3/article-p486.xml?rskey=dVO52l&result=5

... other dengue vaccines, and vaccines against other viral infections. ... of this project was to elucidate the immunological mechanisms induced by live-attenuated and purified inactivated dengue virus ... Systems Biology of the Immune Response to Live and Inactivated Dengue Virus Vaccines. ... of this project was to elucidate the immunological mechanisms induced by live-attenuated and purified inactivated dengue virus ...

https://apps.dtic.mil/sti/citations/AD1116872

The largest outbreak of dengue fever in Tanzania is ongoing. Dengue virus type 1 was diagnosed in a traveler who returned from ... Title : Dengue Virus Type 1 Infection in Traveler Returning from Tanzania to Japan, 2019 Personal Author(s) : Okada, Kazuma; ... We report 301 dengue virus infections among cross-border travelers entering Yunnan Province, China, from Myanmar during 2017. ... Dengue Virus Type 1 Infection in Traveler Returning from Tanzania to Japan, 2019. ...

https://stacks.cdc.gov/view/cdc/81184

... isolated from patients with dengue in Jamaica during 2007 were determined using DNA sequencing and phylogenetic analysis of the ... The genotypes of dengue viruses (DENV) isolated from patients with dengue in Jamaica during 2007 were determined using DNA ... Molecular Epidemiology of Dengue in Jamaica Dengue Virus Genotypes in Jamaica, 2007 ... In contrast, the high genetic diversity in strains of DENV-2 viruses in circulation, the presence of more recently introduced ...

https://www.mona.uwi.edu/fms/wimj/article/1374

Dengue Dengue Virus Epidemiology Mosquitoes Research Risk Factors Vector-borne Infections Viruses ... We investigated dengue virus (DENV) and asymptomatic DENV infections in rural villages of Kampong Cham Province, Cambodia, ... Title : Asymptomatic Dengue Virus Infections, Cambodia, 2012-2013 Personal Author(s) : Ly, Sowath;Fortas, Camille;Duong, Veasna ... Effects of Zika Virus Strain and Aedes Mosquito Species on Vector Competence Cite ...

https://stacks.cdc.gov/view/cdc/79634

The flavivirus genus comprises major human pathogens, such as Dengue (DENV) and Zika (ZIKV) viruses. RIG-I and MDA5 are key ... RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes.. ...

https://research.pasteur.fr/en/publication/rig-i-recognizes-the-5-region-of-dengue-and-zika-virus-genomes-2/

Dengue virus immunoglobulin M detection in a reference laboratory setting during the 2010 dengue virus outbreak on Caribbean ... Zompi S, Harris E. Animal models of dengue virus infection. Viruses. 2012;4(1):62-82. (Review) ... Table 8. Recommendations For Disposition-Of-Care Settings For Dengue. * Figure 1. Average Numbers Of Dengue Fever And Dengue ... 21 West Nile virus is now enzootic in all 48 contiguous states of the United States. West Nile virus is a zoonotic virus, and ...

https://www.ebmedicine.net/topics/infectious-disease/mosquito-borne

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Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects. (1/2185)

Variation in oral susceptibility to dengue type 2 virus of populations of Aedes aegypti from the islands of Tahiti and Moorea, French Polynesia. (2/2185)

Replication of dengue type 2 virus in Culex quinquefasciatus (Diptera: Culicidae). (3/2185)

Bacterial lipopolysaccharide inhibits dengue virus infection of primary human monocytes/macrophages by blockade of virus entry via a CD14-dependent mechanism. (4/2185)

The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids. (5/2185)

Effects of dengue fever during pregnancy in French Guiana. (6/2185)

Bystander target cell lysis and cytokine production by dengue virus-specific human CD4(+) cytotoxic T-lymphocyte clones. (7/2185)

Evaluation of the MRL diagnostics dengue fever virus IgM capture ELISA and the PanBio Rapid Immunochromatographic Test for diagnosis of dengue fever in Jamaica. (8/2185)

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