A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.
An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.
A virulent form of dengue characterized by THROMBOCYTOPENIA and an increase in vascular permeability (grades I and II) and distinguished by a positive pain test (e.g., TOURNIQUET PAIN TEST). When accompanied by SHOCK (grades III and IV), it is called dengue shock syndrome.
The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.
Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.
A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.
Established cell cultures that have the potential to propagate indefinitely.
The reduction or regulation of the population of mosquitoes through chemical, biological, or other means.
A genus of mosquitoes (CULICIDAE) commonly found in tropical regions. Species of this genus are vectors for ST. LOUIS ENCEPHALITIS as well as many other diseases of man and domestic and wild animals.
The study of natural phenomena by observation, measurement, and experimentation.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
The application of scientific knowledge to practical purposes in any field. It includes methods, techniques, and instrumentation.
The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Enhancement of viral infectivity caused by non-neutralizing antibodies. There are at least two mechanisms known to account for this: mediation by Fc receptors (RECEPTORS, FC) or by complement receptors (RECEPTORS, COMPLEMENT). Either the virus is complexed with antiviral IMMUNOGLOBULIN G and binds to Fc receptors, or virus is coated with antiviral IMMUNOGLOBULIN M and binds to complement receptors.
A genus of bacteria comprised of a heterogenous group of gram-negative small rods and coccoid forms associated with arthropods. (From Bergey's Manual of Systematic Bacteriology, vol 1, 1984)
The number of males per 100 females.
A publication issued at stated, more or less regular, intervals.
Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
The act or practice of calling public attention to a product, service, need, etc., especially by paid announcements in newspapers, magazines, on radio, or on television. (Random House Unabridged Dictionary, 2d ed)
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
A family of neutral serine proteases with TRYPSIN-like activity. Tryptases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.
A pathological condition manifested by failure to perfuse or oxygenate vital organs.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
The type species of the FLAVIVIRUS genus. Principal vector transmission to humans is by AEDES spp. mosquitoes.
The lone species of the genus Asfivirus. It infects domestic and wild pigs, warthogs, and bushpigs. Disease is endemic in domestic swine in many African countries and Sardinia. Soft ticks of the genus Ornithodoros are also infected and act as vectors.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects. (1/2185)

The mosquito-borne dengue viruses are widespread human pathogens causing dengue fever, dengue hemorrhagic fever, and dengue shock syndrome, placing 40% of the world's population at risk with no effective treatment. The viral genome is a positive strand RNA that encodes a single polyprotein precursor. Processing of the polyprotein precursor into mature proteins is carried out by the host signal peptidase and by NS3 serine protease, which requires NS2B as a cofactor. We report here the crystal structure of the NS3 serine protease domain at 2.1 A resolution. This structure of the protease combined with modeling of peptide substrates into the active site suggests identities of residues involved in substrate recognition as well as providing a structural basis for several mutational effects on enzyme activity. This structure will be useful for development of specific inhibitors as therapeutics against dengue and other flaviviral proteases.  (+info)

Variation in oral susceptibility to dengue type 2 virus of populations of Aedes aegypti from the islands of Tahiti and Moorea, French Polynesia. (2/2185)

Twenty three samples of Aedes aegypti populations from the islands of Tahiti and Moorea (French Polynesia) were tested for their oral susceptibility to dengue type 2 virus. The high infection rates obtained suggest that the artificial feeding protocol used was more efficient than those previously described. Statistical analysis of the results allowed us to define two distinct geographic areas on Tahiti with respect to the susceptibility of Ae. aegypti: the east coast, with homogeneous infection rates, and the west coast, with heterogeneous infection rates. No geographic differences could be demonstrated on Moorea. The possible mechanisms of this phenomenon are discussed in connection with recent findings on the variability of susceptibility of Ae. aegypti to insecticides.  (+info)

Replication of dengue type 2 virus in Culex quinquefasciatus (Diptera: Culicidae). (3/2185)

We were able to infect Culex quinquefasciatus by the parenteral route with dengue virus type 2. The percentage of mosquitoes infected was dose dependent and we obtained a rate of 45.6% infected Cx. quinquefasciatus when a 10(5.9) MID50 (mosquito infectious dose for 50% of the individuals as measured in Aedes aegypti) of dengue virus type 2 per mosquito was used. Infection was detected by an immunofluorescent assay performed on mosquito head squashes 14 days after infection. The replication of dengue virus in Cx. quinquefasciatus was either at a very low level of magnitude or generated a large number of noninfectious particles since the triturated bodies of infected Cx. quinquefasciatus did not infect Ae. aegypti mosquitoes when inoculated parenterally. We were unable to infect Cx. quinquefasciatus females orally with an artificial meal that infected 100% of Ae. aegypti females. These findings lead us to agree with the consensus that Cx. quinquefasciatus should not be considered a biological vector of dengue viruses.  (+info)

Bacterial lipopolysaccharide inhibits dengue virus infection of primary human monocytes/macrophages by blockade of virus entry via a CD14-dependent mechanism. (4/2185)

Monocytes/macrophages (MO/Mphi) are the major target cells for both dengue virus (DV) and bacterial lipopolysaccharide (LPS), and the aim of this study was to define their interactions. We had found that LPS markedly suppressed DV infection of primary human MO/Mphi when it was added to cultures prior to or together with, but not after, viral adsorption. The inhibitory effect of LPS was direct and specific and was not mediated by LPS-induced secretion of cytokines and chemokines such as tumor necrosis factor alpha, interleukin-1beta (IL-1beta), IL-6, IL-8, IL-12, alpha interferon, MIP-1alpha, and RANTES. In fact, productive DV infection was not blocked but was just postponed by LPS, with a time lag equal to one viral replication cycle. Time course studies demonstrated that LPS was only effective in suppressing DV infection of MO/Mphi that had not been previously exposed to the virus. At various time points after viral adsorption, the level of unbound viruses that remained free in the culture supernatants of LPS-pretreated cultures was much higher than that of untreated controls. These observations suggest that the LPS-induced suppression of DV replication was at the level of virus attachment and/or entry. Blockade of the major LPS receptor, CD14, with monoclonal antibodies MY4 or MoS39 failed to inhibit DV infection but could totally abrogate the inhibitory effect of LPS. Moreover, human serum could significantly enhance the LPS-induced DV suppression in a CD14-dependent manner, indicating that the "binding" of LPS to CD14 was critical for the induction of virus inhibition. Taken together, our results suggest that LPS blocked DV entry into human MO/Mphi via its receptor CD14 and that a CD14-associated cell surface structure may be essential for the initiation of a DV infection.  (+info)

The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids. (5/2185)

NS3 protein of dengue virus type 2 has a serine protease domain within the N-terminal 180 residues. NS2B is required for NS3 to form an active protease involved in processing of the viral polyprotein precursor. The region carboxy terminal to the protease domain has conserved motifs present in several viral RNA-stimulated nucleoside triphosphatase (NTPase)/RNA helicases. To define the functional domains of protease and NTPase/RNA helicase activities of NS3, full-length and amino-terminal deletion mutants of NS3 were expressed in Escherichia coli and purified. Deletion of 160 N-terminal residues of NS3 (as in NS3del.2) had no detrimental effect on the basal and RNA-stimulated NTPase as well as RNA helicase activities. However, mutagenesis of the conserved P-loop motif of the RNA helicase domain (K199E) resulted in loss of ATPase activity. The RNA-stimulated NTPase activity was significantly affected by deletion of 20 amino acid residues from the N terminus or by substitutions of the cluster of basic residues, 184RKRK-->QNGN, of NS3del.2, although both mutant proteins retained the conserved RNA helicase motifs. Furthermore, the minimal NS3 protease domain, required for cleavage of the 2B-3 site, was precisely defined to be 167 residues, using the in vitro processing of NS2B-NS3 precursors. Our results reveal that the functional domains required for serine protease and RNA-stimulated NTPase activities map within the region between amino acid residues 160 and 180 of NS3 protein and that a novel motif, the cluster of basic residues 184RKRK, plays an important role for the RNA-stimulated NTPase activity.  (+info)

Effects of dengue fever during pregnancy in French Guiana. (6/2185)

To determine the effects of dengue fever (DF) during pregnancy, pregnant women presenting with a dengue-like syndrome at a hospital in Saint-Laurent du Maroni, French Guiana, from 1 January 1992 to 1 April 1998 were studied. The diagnosis of DF was made by serological tests, virus isolation on AP 61 mosquito cells, and/or reverse transcriptase polymerase chain reaction analysis. Twenty-two women had either probable or confirmed DF. Dengue virus serotype 2 was detected in four cases, and dengue virus serotype 1 was detected in one. Three fetuses died following the onset of the disease, and three cases of prematurity occurred. All infants appeared normal during physical examination, and no neonatal DF was diagnosed. In conclusion, DF in pregnant women did not cause any infant abnormality, but it may have been responsible for fetal death. The rate of fetal death associated with DF (13.6%) was much higher than the mean rate for the gynecology unit at the hospital (1.9%). However, these differences were not significant, and consequently these preliminary results need to be confirmed.  (+info)

Bystander target cell lysis and cytokine production by dengue virus-specific human CD4(+) cytotoxic T-lymphocyte clones. (7/2185)

Dengue hemorrhagic fever, the severe form of dengue virus infection, is believed to be an immunopathological response to a secondary infection with a heterologous serotype of dengue virus. Dengue virus capsid protein-specific CD4(+) cytotoxic T-lymphocyte (CTL) clones were shown to be capable of mediating bystander lysis of non-antigen-presenting target cells. After activation by anti-CD3 or in the presence of unlabeled antigen-presenting target cells, these clones could lyse both Jurkat cells and HepG2 cells as bystander targets. Lysis of HepG2 cells suggests a potential role for CD4(+) CTL in the liver involvement observed during dengue virus infection. Three CD4(+) CTL clones were demonstrated to lyse cognate, antigen-presenting target cells by a mechanism that primarily involves perforin, while bystander lysis occurred through Fas/Fas ligand interactions. In contrast, one clone used a Fas/Fas ligand mechanism to lyse both cognate and bystander targets. Cytokine production by the CTL clones was also examined. In response to stimulation with D2 antigen, CD4(+) T-cell clones produced gamma interferon, tumor necrosis factor alpha (TNF-alpha) and TNF-beta. The data suggest that CD4(+) CTL clones may contribute to the immunopathology observed upon secondary dengue virus infections through direct cytolysis and/or cytokine production.  (+info)

Evaluation of the MRL diagnostics dengue fever virus IgM capture ELISA and the PanBio Rapid Immunochromatographic Test for diagnosis of dengue fever in Jamaica. (8/2185)

We evaluated two new commercial dengue diagnostic tests, the MRL Diagnostics Dengue Fever Virus IgM Capture ELISA and the PanBio Rapid Immunochromatographic Test, on serum samples collected during a dengue epidemic in Jamaica. The MRL ELISA method correctly identified 98% (78 of 80) of the samples as dengue positive, while the PanBio test identified 100% (80 of 80). Both tests were 100% (20 samples of 20) specific.  (+info)

The World Health Organization estimates that dengue virus causes more than 50 million cases of dengue fever a year. Dengue virus infection is the leading cause of hospitalization and death in children of most tropical Asian countries. There are four different serotypes of dengue virus. Most cases of dengue hemorrhagic fever/dengue shock syndrome are caused by secondary infection with a dengue serotype different from the first serotype the individual was infected with. A vaccine that would be effective in preventing infection by multiple dengue serotypes is desirable. The purpose of this study is to determine the safety of and immune response to two different dengue virus vaccines in individuals who have been previously vaccinated against a different serotype.. This study will last at least 42 days. Participants will be recruited from a database of previous dengue vaccine recipients and will be stratified by the type of vaccine previously received. Participants assigned to Cohort 1 and Cohort 2 ...
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It is known that antibodies to dengue viruses at subneutralizing concentrations enhance dengue virus infection of Fc gamma R+ cells. This phenomenon called antibody-dependent enhancement (ADE) occurs when virus-antibody complexes bind to the Fc gamma R via the Fc portion of the Ig. It has been hypothesized that ADE may be responsible for the pathogenesis of the severe manifestations of dengue virus infection including dengue hemorrhagic fever/dengue shock syndrome. To further analyze the mechanisms of ADE, we prepared bispecific antibodies by chemically cross-linking antidengue virus antibodies to antibodies specific for Fc gamma RI or Fc gamma RII and the non-Fc R molecules beta2 microglobulin, CD15 or CD33 and examined whether these bispecific antibodies could enhance infection. Bispecific antibodies targeting dengue virus to Fc gamma RI or Fc gamma RII enhanced dengue virus infection, consistent with previous reports using conventional antibodies. Furthermore, bispecific antibodies targeting ...
Dengue IgG one step dengue antigen rapid rapid test kit IgM Ab Rapid Test Kit One Step Diagnosis Blood Testing. The Dengue IgG one step dengue antigen rapid rapid test kitIgM Ab Rapid Test Cassette (Whole Blood one step dengue antigen rapid rapid test kitSerum one step dengue antigen rapid rapid test kitPlasma) is a qualitative membrane-based immunoassay for the detection of Dengue antibodies in whole blood, serum, or plasma. The Dengue IgG one step dengue antigen rapid rapid test kitIgM Ab Rapid Test Cassette (Whole Blood one step dengue antigen rapid rapid test kit Serum one step dengue antigen rapid rapid test kit Plasma) is a qualitative membrane-based immunoassay for the ...
Dengue viruses cause dengue fever and the more severe condition, dengue hemorrhagic fever/shock syndrome. Dengue viruses are common in most tropical and subtropical regions of the world and infection with dengue viruses is the leading cause of hospitalization and death in children in many tropical Asian countries. For these reasons, the World Health Organization (WHO) has made the development of a dengue virus vaccine a top priority. This study will evaluate the safety and immunogenicity of two doses of a live attenuated, tetravalent dengue virus vaccine called TetraVax-DV in healthy adults (18-50 years old) who have previously been infected with a dengue virus or other flavivirus or have previously received a flavivirus vaccine. Two different formulations of the TetraVax-DV vaccine will be evaluated.. Participants will be randomly assigned to receive one of two admixtures of the TetraVax-DV vaccine or a placebo. At a baseline study visit (Day 0), participants will undergo a medical history ...
The protective immunity conferred by a set of recombinant vaccinia viruses containing the entire coding sequence of dengue virus type 4 nonstructural glycoprotein NS1 plus various flanking sequences was evaluated by using a mouse encephalitis model. Mice immunized with recombinant vNS1-NS2a, which expresses authentic NS1, were solidly protected against intracerebral dengue virus challenge. However, mice immunized with recombinants vNS1-15%NS2a and vRSVG/NS1-15%NS2a, which express aberrant forms of NS1, were only partially protected (63 to 67% survival rate). Serologic analysis showed that mice immunized with vNS1-NS2a developed high titers of antibodies to NS1 as measured by radioimmunoprecipitation, enzyme-linked immunosorbent assay, and complement-mediated cytolytic assays. In addition, a pool of sera from these animals was protective in a passive transfer experiment. Lower titers of NS1-specific antibodies were detected in sera of animals immunized with vNS1-15%NS2a or vRSVG/NS1-15%NS2a by ...
TY - JOUR. T1 - Retraction. T2 - Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity (Proc Natl Acad Sci USA (2014) 111, (1939-1944) DOI: 10.1073/pnas.1317350111). AU - Messer, William. AU - De Alwis, Ruklanthi. AU - Yount, Boyd L.. AU - Royal, Scott R.. AU - Huynh, Jeremy P.. AU - Smith, Scott A.. AU - Crowe, James E.. AU - Doranz, Benjamin J.. AU - Kahle, Kristen M.. AU - Pfaff, Jennifer M.. AU - White, Laura J.. AU - Sariol, Carlos A.. AU - De Silva, Aravinda M.. AU - Baric, Ralph S.. PY - 2015/5/19. Y1 - 2015/5/19. UR - http://www.scopus.com/inward/record.url?scp=84929484676&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84929484676&partnerID=8YFLogxK. U2 - 10.1073/pnas.1506982112. DO - 10.1073/pnas.1506982112. M3 - Article. C2 - 25941397. AN - SCOPUS:84929484676. VL - 112. SP - E2738. JO - Proceedings of the National Academy of Sciences of the United States of America. JF - Proceedings of the National Academy of ...
Research recently published in PLoS Medicine challenges the dogma of the antibody-dependent enhancement model (ADE) for the development of dengue hemorrhagic fever (DHF). Dengue virus infection usually causes a severe flu like illness, although symptoms may be mild in young children. DHF, however, is a severe and sometimes fatal complication of dengue virus infection that affects about half a million people every year. DHF patients usually fall into two groups; children and adults who become infected with a second dengue virus serotype after an initial primary dengue virus infection with a different serotype, and infants with primary dengue virus infections born to mothers who have some dengue virus immunity. The current model for development of DHF in infants around 6 months old is that anti-dengue virus antibodies transferred from a dengue-immune mother to her child somehow enhance dengue virus infection, resulting in more severe symptoms (the antibody-dependent enhancement model). A ...
Dengue virus infection is one of the most common mosquito-borne illnesses worldwide, with nearly four billion people living in at risk areas throughout the world. Reported cases to World Health Organization continue to rise exponentially with an estimated 50 - 100 million symptomatic cases, mostly in Asia. Most clinical cases present with a self-limited viral illness, but some experience life-threatening severe disease. Four serotypes of dengue virus exist; infection by one serotype confers long lasting homotypic immunity, but does not confer heterotypic immunity to another serotype. Subsequent infection from a different dengue serotype can lead to the development of severe dengue. Antibody-dependent enhancement of dengue virus infection has been implicated in the development of severe disease. There have been various efforts to develop vaccines against dengue, including subunit vaccines that use only the viral envelope glycoprotein, or portions thereof. Those efforts are hampered by the ...
Dengue virus infects approximately 100 million people annually, but there is no available therapeutic treatment. The mimetic peptide, DN59, consists of residues corresponding to the membrane interacting, amphipathic stem region of the dengue virus envelope (E) glycoprotein. This peptide is inhibitory to all four serotypes of dengue virus, as well as other flaviviruses. Cryo-electron microscopy image reconstruction of dengue virus particles incubated with DN59 showed that the virus particles were largely empty, concurrent with the formation of holes at the five-fold vertices. The release of RNA from the viral particle following incubation with DN59 was confirmed by increased sensitivity of the RNA genome to exogenous RNase and separation of the genome from the E protein in a tartrate density gradient. DN59 interacted strongly with synthetic lipid vesicles and caused membrane disruptions, but was found to be non-toxic to mammalian and insect cells. Thus DN59 inhibits flavivirus infectivity by interacting
We analyzed dengue virus-specific CD4+ CD8- cytotoxic T lymphocytes (CTL) at the clonal level to further understand their role in dengue virus infections. Stimulation of peripheral blood mononuclear cells from two dengue virus type 4 (D4V)-immune donors with live D4V or noninfectious D4V antigen generated 17 HLA class II-restricted CD4+ CTL capable of specific lysis of dengue virus antigen-treated autologous lymphoblastoid cell lines. Thirteen clones were D4V specific, three clones were cross-reactive for D2V and D4V, and one clone was cross-reactive for D1V, D3V, and D4V. Antigen recognition by six D4V-specific clones and three D2V- and D4V-cross-reactive clones was restricted by HLA-DR7. Five D4V-specific CD4+ CTL clones lysed autologous lymphoblastoid cell lines infected with a dengue virus-vaccinia virus recombinant containing the E gene of D4V, whereas three serotype-cross-reactive CTL clones did not. These results indicate that E-specific clones are serotype specific and HLA-DR7 restricted in
TY - JOUR. T1 - Prevalence of dengue virus serotypes in the 2017 outbreak in Peshawar, KP, Pakistan. AU - Khan, Najeeb Ullah. AU - Danish, Lubna. AU - Khan, Hydayat Ullah. AU - Shah, Maryam. AU - Ismail, Muhammad. AU - Ali, Ijaz. AU - Petruzziello, Arnolfo. AU - Sabatino, Rocco. AU - Guzzo, Annunziata. AU - Botti, Gerardo. AU - Iqbal, Aqib. N1 - © 2020 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.. PY - 2020/9. Y1 - 2020/9. N2 - BACKGROUND: Dengue is a viral disease, transmitted by infected Aedes aegypti and Aedes albopictus female mosquitoes. Worldwide, 96 million infections were estimated in 2010. The dengue virus comprises four distinct serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) which belong to the genus Flavivirus. Determining the serotypes during dengue outbreaks is crucial for its effective management in terms of diagnostics improvement and polyvalent vaccine development. The aim of the present study is to determine the prevalence rate of ...
Although endothelial cells have been speculated to be a target in the pathogenesis of dengue hemorrhagic fever (DHF), there has been little evidence linking dengue virus infection to any alteration in endothelial cell function. In this study, we show that human umbilical vein endothelial cells become activated when exposed to culture fluids from dengue virus-infected peripheral blood monocytes. Maximum activation was achieved with culture fluids from monocytes in which virus infection was enhanced by the addition of dengue virus-immune serum, thus correlating with epidemiological evidence that prior immunity to dengue virus is a major risk factor for DHF. Activation was strongest for endothelial cell expression of VCAM-1 and ICAM-1. In contrast, activation of endothelial cell E-selectin expression appeared to be more transient, as indicated by its detection at 3 h, but not at 16 h, of treatment. Treatment of monocyte culture fluids with anti-tumor necrosis factor alpha (TNF-alpha) antibody ...
To date, dengue virus evolution has mainly been addressed by studies conducted at the between-host level. Like other pathogens with high mutation rate and
This research advances the fundamental understanding of how dengue virus replicates. Although platelets lack a nucleus, these tiny blood cells contain all the machinery needed to synthesize proteins and replicate RNA. The findings of this study are unprecedented and show that dengue hijacks blood platelets, commandeering the cells machinery to produce viral proteins and replicate its own genome. How this links to thrombocytopenia normally seen with dengue virus is still unclear. The possibility that viral antigens are exposed directly on platelets is now being considered for the first time. Dengue virus replicating in red blood cell units was a surprising finding as these cells do not have replication machinery.. The involvement of other residual cells found in red blood cell units is suspected. Blood donor systems worldwide are vulnerable to dengue virus. There have been five documented cases of dengue transmission by blood transfusion, all occurring in regions where dengue is present or ...
Title: Steady-State Cleavage Kinetics for Dengue Virus Type 2 Ns2b-Ns3(Pro) Serine Protease With Synthetic Peptides. VOLUME: 10 ISSUE: 1. Author(s):Rabuesak Khumthong, Pornwarat Niyomrattanakit, Santad Chanprapaph, Chanan Angsuthanasombat, Sakol Panyim and Gerd Katzenmeier. Affiliation:Laboratory of Molecular Virology, Institute of Molecular Biology and Genetics, Mahidol University, SalayaCampus, Phutthamonthon No. 4 Rd., Nakornpathom 73170, Thailand. Keywords:dengue virus, ns2b-ns3, serine protease, peptide, substrate, assay, kinetic, cleavage kinetics. Abstract: The N-terminal part of the NS3 protein from dengue virus contains a trypsin-like serine protease responsible for processing the nonstructural region of the viral polyprotein. Enzymatic activity of the NS2B-NS3(pro) precursor incorporating a full-length NS2B cofactor of dengue virus type 2 was examined by using synthetic dodecamer peptide substrates encompassing native cleavage sequences of the NS2A/NS2B, NS2B / NS3, NS3 / NS4A and NS4B ...
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|strong|Recombinant dengue virus type 4 NS1 antigen|/strong| is a purified preparation of the dengue virus serotype 4 (DENV4), non-structural protein 1 (NS1). DENV4 is one of four (DENV1-4) antigenica…
Author(s): Forshey, Brett M; Reiner, Robert C; Olkowski, Sandra; Morrison, Amy C; Espinoza, Angelica; Long, Kanya C; Vilcarromero, Stalin; Casanova, Wilma; Wearing, Helen J; Halsey, Eric S; Kochel, Tadeusz J; Scott, Thomas W; Stoddard, Steven T | Abstract: BackgroundNearly half of the worlds population is at risk for dengue, yet no licensed vaccine or anti-viral drug is currently available. Dengue is caused by any of four dengue virus serotypes (DENV-1 through DENV-4), and infection by a DENV serotype is assumed to provide life-long protection against re-infection by that serotype. We investigated the validity of this fundamental assumption during a large dengue epidemic caused by DENV-2 in Iquitos, Peru, in 2010-2011, 15 years after the first outbreak of DENV-2 in the region.Methodology/principal findingsWe estimated the age-dependent prevalence of serotype-specific DENV antibodies from longitudinal cohort studies conducted between 1993 and 2010. During the 2010-2011 epidemic, active dengue cases were
To describe cases of dengue virus (DENV) concurrent infections in patients from both local and international traveler visiting Bali, Indonesia. During a hospital-based study, 260 patients (from 161 local and 99 international traveler patients) were recruited. Among them, 190 were positive by DENV RT-PCR in which eight patients (five local and three international travelers) detected as having concurrent infections by two different DENV serotypes. Among the eight patients, the common dengue symptoms diagnosed were fever, headache, and myalgia. Six cases (75%) were diagnosed with dengue fever (DF) while two cases (25%) manifested with bleeding and were diagnosed with dengue hemorrhagic fever (DHF) grade 1. The DENVs concurrent infections involved all four DENV serotypes known to be circulating in Bali. Although cases of DENV concurrent infections have been implicated with severe manifestation, we observed that most of concurrent infections cases in our study were of mild clinical manifestation, that may be
The human C-type lectin-like molecule CLEC5A is a critical macrophage receptor for dengue virus. The binding of dengue virus to CLEC5A triggers signaling through the associated adapter molecule DAP12, stimulating proinflammatory cytokine release. We have crystallized an informative ensemble of CLEC5A structural conformers at 1.9-Å resolution and demonstrate how an on-off extension to a β-sheet acts as a binary switch regulating the flexibility of the molecule. This structural information together with molecular dynamics simulations suggests a mechanism whereby extracellular events may be transmitted through the membrane and influence DAP12 signaling. We demonstrate that CLEC5A is homodimeric at the cell surface and binds to dengue virus serotypes 1-4. We used blotting experiments, surface analyses, glycan microarray, and docking studies to investigate the ligand binding potential of CLEC5A with particular respect to dengue virus. This study provides a rational foundation for understanding the dengue
Everyone knows how mosquitos can wreck an end-of-summer picnic. But in some climates, these pesky intruders persist and carry a variety of detrimental diseases-some with no preventative vaccines or targeted therapies. One such passenger is dengue virus (DENV), which infects up to 400 million people each year and comes in several serotypes (1 to 4) and disease presentations-from mild infection to severe disease and sometimes death. But to treat or prevent dengue requires that we have a more complete picture of the disease pathology. Now, Modhiran et al. and Beatty et al. describe the results of in vitro and in vivo experiments that point to circulating dengue virus non-structural protein 1 (NS1) and the innate immune Toll-like receptor 4 (TLR4) as a focus for basic scientists as well as vaccine and drug developers.. DENV infection protects a patient from future reinfection with the same DENV serotype as well as producing temporary immune protection from severe dengue disease caused by a different ...
The relationship between the percent phagocytosis of platelets by differentiated THP-1 cells was examined using flowcytometry and the peripheral platelet counts as well as platelet-associated IgG (PAIgG) in 36 patients with secondary dengue virus (DV) infections. The percent phagocytosis and the levels of PAIgG were significantly increased in these patients during the acute phase compared with the healthy volunteers. The increased percent phagocytosis and PAIgG found during the acute phase significantly decreased during the convalescent phase. An inverse correlation between platelet count and the percent phagocytosis (P = 0.011) and the levels of PAIgG (P = 0.041) was found among these patients during the acute phase. No correlation was found, however, between the percent phagocytosis and the levels of PAIgG. Our present data suggest that accelerated platelet phagocytosis occurs during the acute phase of secondary DV infections, and it is one of the mechanisms of thrombocytopenia in this disease.
Although Wolbachia can grow in a variety of tissues, it has a particular attachment to gonads and reproduces itself through infecting female eggs.. To ensure its spread, Wolbachia uses several methods, including ensuring that all the male offspring die, causing infected males to develop as females or even allowing females to produce fertile offspring without ever mating, continues Dr. Timmer. Once in cells, Wolbachia seems to interfere with many (but not all) other pathogens, including dengue virus. Were just not sure how this happens. Theres some signs that Wolbachia competes with other parasites, that it activates the insect version of an immune system, and that it activates other defenses in the mosquitoes. But which (if any) of these is involved in limiting dengue virus isnt clear. But it is clear that mosquitoes with Wolbachia growing in them produce far less dengue virus, and thus pose less of a risk of passing the virus on to new victims.. Elaborating on the dengue threat, Prof. ...
The four dengue virus serotypes (DENV1 to DENV4) are mosquito-borne flaviviruses that cause up to ~100 million cases of dengue annually worldwide. Severe disease is thought to result from immunopathogenic processes involving serotype cross-reactive antibodies and T cells that together induce vasoactive cytokines, causing vascular leakage that leads to shock. However, no viral proteins have been directly implicated in triggering endothelial permeability, which results in vascular leakage. DENV nonstructural protein 1 (NS1) is secreted and circulates in patients blood during acute infection; high levels of NS1 are associated with severe disease. We show that inoculation of mice with DENV NS1 alone induces both vascular leakage and production of key inflammatory cytokines. Furthermore, simultaneous administration of NS1 with a sublethal dose of DENV2 results in a lethal vascular leak syndrome. We also demonstrate that NS1 from DENV1, DENV2, DENV3, and DENV4 triggers endothelial barrier ...
Recombinant Dengue virus 2 Dengue Virus 2 envelope protein is an Escherichia coli Protein fragment 298 to 400 aa range, | 95% purity and validated in SDS-PAGE.
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The understanding of immunological interactions among the four dengue virus (DENV) serotypes and their epidemiological implications is often hampered by the lack of individuallevel infection history. Using a statistical framework that infers full infection history, we analyze a prospective pediatric cohort in Nicaragua to characterize how infection history modulates the risks of DENV infection and subsequent clinical disease. After controlling for age, one prior infection is associated with 54% lower, while two or more are associated with 91% higher, risk of a new infection, compared to DENV-naive children. Children ,8 years old have 55% and 120% higher risks of infection and subsequent disease, respectively, than their younger peers. Among children with ≥1 prior infection, intermediate antibody titers increase, whereas high titers lower, the risk of subsequent infection, compared with undetectable titers. Such complex dependency needs to be considered in the design of dengue vaccines and ...
Detection of dengue virus nucleic acid in serum is suggestive of recent exposure and acute infection with dengue virus.. The presence of dengue virus nucleic acid in serum can be used as a marker for acute-phase infection. Patients with a history of symptoms for more than 1 week may be negative by molecular tests (ie, real-time PCR) and may require serologic testing to confirm the diagnosis of dengue virus infection.. ...
Abstract. After the report of an outbreak of dengue virus serotype 2 in 2014 in Nampula and Pemba cities, northern Mozambique, a surveillance system was established by the National Institute of Health. A study was performed during 2015-2016 to monitor the trend of the outbreak and confirm the circulating serotype of dengue virus (DENV). After the inclusion of consenting patients who met the case definition, samples from 192 patients were tested for the presence of nonstructural protein 1 antigen, and 60/192 (31%) samples were positive. Further analysis included DENV IgM antibodies, with 39 (20%) IgM positive cases. Reverse transcriptase (RT) PCR was performed for identification of the prevailing DENV serotype; 21/23 tested samples were DENV-2 positive, with DENV-2 present in both affected cities. When sequencing DENV, phenotype Cosmopolitan was identified. The surveillance indicates ongoing spread of DENV-2 in northern Mozambique 2 years after the first report of the outbreak.
Dengue virus (DENV) causes the most prevalent arthropod-borne viral disease in humans. Although Aedes mosquitoes transmit DENV when probing for blood in the skin, no information exists on DENV infection and immune response in the dermis, where the blood vessels are found. DENV suppresses the interferon response, replicates, and causes disease in humans but not wild-type mice. Here, we used mice lacking the interferon-α/β receptor (Ifnar(-/-)), which had normal cell populations in the skin and were susceptible to intradermal DENV infection, to investigate the dynamics of early DENV infection of immune cells in the skin. CD103(+) classical dendritic cells (cDCs), Ly6C(-) CD11b(+) cDCs, and macrophages in the steady-state dermis were initial targets of DENV infection 12-24 hours post-inoculation but then decreased in frequency. We demonstrated recruitment of adoptively-transferred Ly6C(high) monocytes from wild-type and Ifnar(-/-) origin to the DENV-infected dermis and differentiation to Ly6C(+) ...
TY - JOUR. T1 - Prolonged persistence of IgM against dengue virus detected by commonly used commercial assays. AU - Chien, Yu-Wen. AU - Liu, Zi Hu. AU - Tseng, Fan Chen. AU - Ho, Tzu Chuan. AU - Guo, How-Ran. AU - Ko, Nai-Ying. AU - Ko, Wen-Chien. AU - Perng, Guey-Chuen. PY - 2018/4/2. Y1 - 2018/4/2. N2 - Background: Initial symptoms of dengue fever are non-specific, and thus definite diagnosis requires laboratory confirmation. Detection of IgM against dengue virus (DENV) has become widely used for dengue diagnosis. Understanding the persistence of anti-DENV IgM in subjects after acute infection is essential in order to interpret test results correctly. Although the longevity of anti-DENV IgM has been vehemently investigated in symptomatic children, anti-DENV IgM persistence in adults and in asymptomatically infected people have seldom been reported. Methods: We prospectively investigated 44 adults with detectable anti-DENV IgM in a serosurvey conducted in the 2015 dengue epidemic in Tainan, ...
Dengue is a major mosquito-borne disease currently with no effective antiviral or vaccine available. Effort to find antivirals for it has focused on bioflavonoids, a plant-derived polyphenolic compounds with many potential health benefits. In the present study, antiviral activity of four types of bioflavonoid against dengue virus type -2 (DENV-2) in Vero cell was evaluated. Anti-dengue activity of these compounds was determined at different stages of DENV-2 infection and replication cycle. DENV replication was measured by Foci Forming Unit Reduction Assay (FFURA) and quantitative RT-PCR. Selectivity Index value (SI) was determined as the ratio of cytotoxic concentration 50 (CC50) to inhibitory concentration 50 (IC50) for each compound. The half maximal inhibitory concentration (IC50) of quercetin against dengue virus was 35.7 μg mL-1 when it was used after virus adsorption to the cells. The IC50 decreased to 28.9 μg mL-1 when the cells were treated continuously for 5 h before virus infection and up to
Anti-dengue virus immunoglobulin M kits were evaluated. Test sensitivities were 21%-99% and specificities were 77%-98% compared with reference ELISAs. dengue igg igm dengue rapid test kit price lower °C 2-30 2-8 2-8 2-8 2-8 Rapid diagnostic tests Test name Dengue duo cassette Hapalyse dengue-M PA kit Dengucheck WB SD dengue IgG/IgM Company, location Panbio Diagnostics Pentax, Tokyo dengue igg igm dengue rapid test kit price ...
Dengue virus is coated by an icosahedral shell of 90 envelope protein dimers that convert to trimers at low pH and promote fusion of its membrane with the membrane of the host endosome. We provide the first estimates for the free energy barrier and minimum for two key steps in this process: host membrane bending and protein-membrane binding. Both are studied using complementary membrane elastic, continuum electrostatics and all-atom molecular dynamics simulations. The predicted host membrane bending required to form an initial fusion stalk presents a 22-30 kcal/mol free energy barrier according to a constrained membrane elastic model. Combined continuum and molecular dynamics results predict a 15 kcal/mol free energy decrease on binding of each trimer of dengue envelope protein to a membrane with 30% anionic phosphatidylglycerol lipid. The bending cost depends on the preferred curvature of the lipids composing the host membrane leaflets, while the free energy gained for protein binding depends ...
There is growing evidence of the influence of sphingosine kinase (SK) enzymes on viral infection. Here, the role of sphingosine kinase 2 (SK2), an isoform of SK prominent in the brain, was defined during dengue virus (DENV) infection. Chemical inhibition of SK2 activity using two different SK2 inhibitors, ABC294640 and K145, had no effect on DENV infection in human cells in vitro. In contrast, DENV infection was restricted in SK2−/− immortalized mouse embryonic fibroblasts (iMEFs) with reduced induction of IFN-β mRNA and protein, and mRNA for the IFN-stimulated genes (ISGs) viperin, IFIT1, IRF7 and CXCL10 in DENV-infected SK2−/− compared to WT iMEFs. Intracranial (ic) DENV injection in C57BL/6 SK2−/− mice induced body weight loss earlier than in WT mice but DENV RNA levels were comparable in the brain. Neither SK1 mRNA or sphingosine-1-phosphate (S1P) levels were altered following ic DENV infection in WT or SK2−/− mice but brain S1P levels were reduced in all SK2−/− mice,
TY - JOUR. T1 - Membrane topology and function of dengue virus NS2A protein. AU - Xie, Xuping. AU - Gayen, Shovanlal. AU - Kang, Cong Bao. AU - Yuan, Zhiming. AU - Shi, Pei Yong. PY - 2013/4/1. Y1 - 2013/4/1. N2 - Flavivirus nonstructural protein 2A (NS2A) is a component of the viral replication complex that functions in virion assembly and antagonizes the host immune response. Although flavivirus NS2A is known to associate with the endoplasmic reticulum (ER) membrane, the detailed topology of this protein has not been determined. Here we report the first topology model of flavivirus NS2A on the ER membrane. Using dengue virus (DENV) NS2A as a model, we show that (i) the N-terminal 68 amino acids are located in the ER lumen, with one segment (amino acids 30 to 52) that interacts with ER membrane without traversing the lipid bilayer; (ii) amino acids 69 to 209 form five transmembrane segments, each of which integrally spans the ER membrane; and (iii) the C-terminal tail (amino acids 210 to 218) ...
Last week the World Health Organization (WHO) reported that dengue is the worlds fastest-spreading tropical disease. As reported by Reuters, dengue is a threat that is present in more than 125 countries.. The WHO estimates that 50 and 100 million dengue infections occur worldwide every year, but acknowledges that this is likely a conservative figure. The CDC estimates that about 2.5 billion people, or 40% of the worlds population, live in areas where there is a risk of dengue transmission. The areas in which dengue is endemic include Asia, Africa and Latin America, but it is present on all continents.. Dengue fever is caused by any one of four dengue virus serotypes and is transmitted by the Aedes aegypti and Aedes albopictus mosquito species. Infection with one serotype does not provide immunity against other dengue serotypes, and multiple infections put people at risk for dengue hemorrhagic fever and dengue shock syndrome. Dengue symptoms typically begin four to seven days following the ...
Dengue fever is a severe health problem in tropical areas, with two-thirds of the world population at risk of infection (24). Four virus serotypes and even more quasispecies can be differentiated both in the transmitting insect (A. aegypti) and in the blood of patients with acute dengue fever (26). During recent decades Europe has been free of dengue infections, but as a result of increasing tourism every year several thousand tourists return to European countries with acute dengue fever.. In the second half of 1998 we diagnosed 172 dengue patients. All patients were European tourists, most of whom had experienced a disease with high fever and headache for several days. Usually early serum samples were taken 4 to 8 days after the onset of symptoms. Therefore, early serum samples without dengue virus antibodies at all or with either IgG or IgM antibodies were obtained from only 25 patients (15%). In 20 early samples viral RNA could be demonstrated by TaqMan PCR, in one case even in the presence ...
Author Summary India represents ~50% of the global population estimated to be at risk of dengue. Severe dengue, which is potentially fatal, correlates with very high virus load, reduction in platelet counts and haemorrhage. Antiviral therapy to reduce high virus load may be beneficial in attenuating disease severity. We have explored Indian traditional medicine, Ayurveda, to identify plants that could be a source of dengue inhibitory activity. We show that an alcoholic extract prepared from Cissampelos pareira Linn inhibited the replication of dengue viruses in living cells in culture and protected mice against dengue infection. It also showed antipyretic and anti-inflammatory effects. Importantly, this extract did not show any toxic effects in rats and did not affect platelets and red blood cells. This observation is critical as dengue fever is commonly treated with antipyretics. In a dengue-endemic resource-poor country as India, the C. pareira plant may serve as a source for the development of an
Dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) are considered the most medically important and widespread mosquito-bor...
BACKGROUND: Dengue virus is endemic in tropical and sub-tropical resource-poor countries. Dengue illness can range from a nonspecific febrile illness to a severe disease, Dengue Shock Syndrome (DSS), in which patients develop circulatory failure. Earlier diagnosis of severe dengue illnesses would have a substantial impact on the allocation of health resources in endemic countries. METHODS AND FINDINGS: We compared clinical laboratory findings collected within 72 hours of fever onset from a prospective cohort children presenting to one of two hospitals (one urban and one rural) in Thailand. Classification and regression tree analysis was used to develop diagnostic algorithms using different categories of dengue disease severity to distinguish between patients at elevated risk of developing a severe dengue illness and those at low risk. A diagnostic algorithm using WBC count, percent monocytes, platelet count, and hematocrit achieved 97% sensitivity to identify patients who went on to develop DSS while
Dengue fever is a serious threat for public health and induces various inflammatory cytokines and mediators, including galectins and glycoproteins. Diverse immune responses and immunological pathways are induced in different phases of dengue fever progression. However, the status of serum galectins and glycoproteins is not fully determined. The aim of this study was to investigate the serum concentration and potential interaction of soluble galectin-1, galectin-3, galectin-9, galectin-3 binding protein (galectin-3BP), glycoprotein 130 (gp130), and E-, L-, and P-selectin in patients with dengue fever in acute febrile phase. In this study, 317 febrile patients (187 dengue patients, 150 non-dengue patients that included 48 patients with bacterial infection and 102 patients with other febrile illness) who presented to the emergency department and 20 healthy controls were enrolled. Our results showed the levels of galectin-9 and galectin-3BP were significantly higher in dengue patients than those in healthy
Death because of fever is increasing day by day. Dengue fever is the main type of fever which leads to this increased mortality rate It is important to prevent the disease. if the disease caused have to be treated properly. Proper medicine and the rest is the main defensive way to prevent dengue fever dengue fever is also called break bone fever. Dengue fever is a viral disease the dengue virus which is spread by mosquito is the main reason behind dengue fever.. If once dengue fever host it will make antibodies over the body for the lifetime the first time of dengue fever is known as Type 1 dengue fever is Dengue fever caused more than one time then then it would be type 2 dengue fever.. ...
Schon mal was von dem gefährlichen Virus Denguefieber gehört? Mindestens genauso ansteckend ist der treibende Cumbia-Future-Sound des Duos Dengue Dengue Dengue! aus der peruanischen Millionenmetropole Lima. Mit wobbeligen Bässen ausgeliehen aus dem Dubstep, futuristischen Sounds seziert aus dem Techno und psychedelischen Sounds inspiriert aus der 70er Jahre Cumbia-Chicha hebt Dengue Dengue Dengue! den Cumbia-Digital Sound auf ein neues Level. Auf den Live-Shows von Dengue Dengue Dengue! bekommt man das Gefühl mit einem UFO direkt auf dem peruanischen Inkatempel Machu-Pichu zu landen - inmitten eines futuristischen Technoraves mit Ausblick über den amazonischen Urwald. Dengue Dengue Dengue! ist ein junges Duo bestehend aus Felipe Salmon und Rafael Pereira. Beide sind auch Teil des Colectivo Auxiliar, ein peruanisches Sound-Laboratorium. Der Name Dengue Dengue Dengue! entspringt einer Enrique Lynch Platte, der darauf einen Rhythmus spielt, der sich Dengue nennt. Das Projekt überzeugt von ...
Currently, several assays can diagnose acute dengue infection. However, none of these assays can predict the severity of the disease. Biomarkers that predicts the likelihood that a dengue patient will develop a severe form of the disease could permit more efficient patient triage and allows better supportive care for the individual in need, especially during dengue outbreaks. We measured 20 plasma markers i.e. IFN-γ, IL-10, granzyme-B, CX3CL1, IP-10, RANTES, CXCL8, CXCL6, VCAM, ICAM, VEGF, HGF, sCD25, IL-18, LBP, sCD14, sCD163, MIF, MCP-1 and MIP-1β in 141 dengue patients in over 230 specimens and correlate the levels of these plasma markers with the development of dengue without warning signs (DWS−), dengue with warning signs (DWS+) and severe dengue (SD). Our results show that the elevation of plasma levels of IL-18 at both febrile and defervescence phase was significantly associated with DWS+ and SD; whilst increase of sCD14 and LBP at febrile phase were associated with severity of dengue disease
TY - JOUR. T1 - Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities. AU - Chuang, Yung Chun. AU - Lin, Yee Shin. AU - Liu, Hsiao Sheng. AU - Wang, Jen Reng. AU - Yeh, Trai Ming. PY - 2013. Y1 - 2013. N2 - Dengue virus (DENV) infection may result in severe life-threatening Dengue haemorrhagic fever (DHF). The mechanisms causing haemorrhage in those with DHF are unclear. In this study, we demonstrated that antibodies against human thrombin were increased in the sera of Dengue patients but not in that of patients infected with other viruses. To further characterise the properties of these antibodies, affinity-purified anti-thrombin antibodies (ATAs) were collected from Dengue patient sera by thrombin and protein A/L affinity columns. Most of the ATAs belonged to the IgG class and recognized DENV nonstructural protein 1 (NS1). In addition, we found that dengue patient ATAs also cross-reacted with human plasminogen (Plg). Functional studies in ...
In the 20th century dengue fever became one of the leading causes of morbidity and mortality throughout the tropics. The dengue virus is an arbovirus transmitted by Aedes mosquitoes. There are four distinct serotypes of dengue arbovirus (DENV-1, 2, 3, 4). According to the World Health Organization, a person infected by one of the dengue viruses can develop symptoms ranging from the classical self-limiting form characterized by high temperature, headache, myalgia, and arthralgia to the severe, potentially fatal, form known as dengue shock syndrome. For over 40 years the main explanation for the pathogenesis of dengue has been based on the antibody-dependent enhancement (ADE) concept stating that enhancing antibodies acquired during a primary infection increase the number of infected cells, and thus the level of viremia, during secondary infection. However the severity of dengue is not limited to dengue shock syndrome and there are many cases that do not conform to the ADE concept. A meta-analysis could
Infection by flaviviruses such as dengue virus serotypes (DENV 1-4), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBE), yellow fever virus (YFV) and West Nile virus (WNV) impact millions of lives and cause tens of thousands of mortalities each year. Dengue is a global public health emergency especially since there is no preventative vaccine or antiviral treatment for dengue disease. Dengue: Methods and Protocols offers the increasing number of dengue researchers a one-stop protocol book with techniques compiled from the leading laboratories working on dengue. Chapters cover topics such as dengue virus isolation from clinical samples, quantification of human antibodies against the virus, assays to quantify the virus particles, the widely used mouse model to study dengue pathogenesis, vaccine and antiviral efficacies. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and
As of Feb. 6, there were 12,904 suspected cases of dengue reported in 2016, including 49 deaths. This is slightly higher than that reported during the same period in 2015 when 12,766 cases were reported.. Dengue is an important arboviral infection that continues to cause a substantial public health burden in Asia and the Pacific.. Dengue is transmitted by the bite of a mosquito infected with one of the four dengue virus serotypes. It is a febrile illness that affects infants, young children and adults with symptoms appearing 3-14 days after the infective bite.. Dengue is not transmitted directly from person-to-person and symptoms range from mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash.. Related: Dengvaxia now available in the Philippines: Sanofi Pasteur. Severe dengue (also known as dengue hemorrhagic fever) is characterized by fever, abdominal pain, persistent vomiting, bleeding and breathing difficulty and is a ...
This study describes the natural history of dengue virus (DENV) infection in rhesus monkeys exposed to the bites of DENV-infected Aedes aegypti mosquitoes. Dengue virus-infected mosquitoes were generated by either intrathoracic inoculation or by oral feeding on viremic blood meals. Each of the six rhesus monkeys that were fed upon by intrathoracically infected mosquitoes developed NS1 antigenemia and an IgM response; viremia was detected in 4/6 individuals. No virological or immunological evidence of DENV infection was detected in the three monkeys exposed to mosquitoes that had been orally infected with DENV. These results demonstrate the utility of mosquito-borne challenge of rhesus monkeys with DENV.
|i|Introduction.|/i| Dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), and expanded dengue syndrome (EDS) with atypical presentations, thus posing a diagnostic dilemma. Unless we are aware of these presentations, diagnosis as well as early initiation of treatment becomes difficult. We studied the various clinical presentations of dengue infection during an outbreak of disease in 2015.|i| Materials and Methods|/i|. A total of 115 confirmed cases of dengue infection from Department of Medicine of Deen Dayal Upadhyay Hospital, New Delhi, were enrolled in this observational study.|i| Results.|/i| The common signs and symptoms of dengue infection were fever, headache, body ache, backache, retro-orbital pain, bleeding manifestations, and rash in 100%, 87%, 86%, 58%, 41%, 21%, and 21%, respectively. Nonspecific or warning
AFUCOSYLATED MATERNAL ANTI-DENGUE IGGS ARE A BIOMARKER FOR SUSCEPTIBILITY TO SEVERE DENGUE DISEASE IN INFANTS. Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have developed a method for determining infant susceptibility to severe dengue disease through measurement of maternal anti-dengue IgG. Mortality rates in severe dengue disease can exceed 20% when patients are not hospitalized but can be reduced to less than 1% with inpatient care. Therefore, the identification of biomarkers for increased susceptibility to dengue disease could dramatically reduce mortality rates by enabling early hospitalization of those at highest risk for disease progression. Here, the inventors conducted a global analysis of anti-dengue IgGs from mothers of infants with known disease severity during primary dengue infections in order to identify features of maternal IgGs that indicate dengue disease risk in infants.. Stage of Research The glycosylation state of the IgG Fc domain plays a role in ...
Dengue is not transmitted directly from person-to-person. Instead, it is transmitted by the bite of a mosquito infected with one of the four dengue virus serotypes. It is a febrile illness that affects infants, young children and adults. Symptoms range from mild fever to incapacitating high fever with rash, severe headache, pain behind the eyes, as well as muscle and joint pain. The disease is also known as breakbone fever due to the severe pain it can cause. Severe dengue (also known as dengue hemorrhagic fever) affects mainly children, and is characterized by fever, abdominal pain, persistent vomiting, bleeding and breathing difficulty - it is potentially deadly.. The WHO estimates that about half of the worlds population is now at risk. However, at this time, there is no licensed vaccine or any specific medicine to treat dengue. Fortunately, there is hope. Several vaccines are in the final steps of development, with the one produced by the French pharmaceutical company Sanofi Pasteur ...
Dengue continues to be a major international public health concern. Despite that, there is no clinically approved antiviral for treatment of dengue virus (DENV) infections. In this study, geraniin extracted from the rind of Nephelium lappaceum was shown to inhibit the replication of DENV-2 in both in vitro and in vivo experiments. The effect of geraniin on DENV-2 RNA synthesis in infected Vero cells was tested using quantitative RT-PCR. The in vivo efficacy of geraniin in inhibiting DENV-2 infection was then tested using BALB/c mice with geraniin administered at three different times. The differences in spleen to body weight ratio, DENV-2 RNA load and liver damage between the three treatment groups as compared to DENV-2 infected mice without geraniin administration were determined on day eight post-infection. Quantitative RT-PCR confirmed the decrease in viral RNA synthesis of infected Vero cells when treated with geraniin. Geraniin seemed to provide a protective effect on infected BALB/c mice liver
Three tetravalent formulations of chimeric dengue (DENVax) viruses containing the pre-membrane and envelope genes of serotypes 1-4 expressed by the attenuated DENV-2 PDK-53 genome were tested for safety, immunogenicity, and efficacy in cynomolgus macaques (Macaca fascicularis). Subcutaneous injection of the DENVax formulations was well-tolerated. Low levels of viremia of only one of the four vaccine viruses were detected yet virus neutralizing antibody titers were induced against all four dengue virus serotypes after one or two administrations of vaccine. All animals immunized with the high-dose formulation were protected from viremia, and all immunized animals were completely protected from DENV-3 and DENV-4 challenge. A lower dose of DENVax formulation partially protected animals from DENV-1 or DENV-2 challenge. In contrast, all control animals developed high levels of viremia for multiple days after challenge with DENV 1-4. This study highlights the immunogenicity and efficacy of the ...
For countries considering vaccination as part of their dengue control program, a pre-vaccination screening strategy would be the preferred option, in which only dengue-seropositive persons are vaccinated.. Conventional serological testing for dengue virus IgG (e.g. dengue IgG ELISA) could be used to identify persons who have had previous dengue infections. Sensitivity and specificity of dengue IgG ELISA should be assessed in a local context, and will depend on the prevalence of other flaviviruses, and past use of flavivirus vaccines (such as Japanese encephalitis and yellow fever vaccines). Currently available rapid diagnostic tests - despite their lower sensitivity and specificity to detect past dengue infection compared with conventional dengue IgG ELISA - could be considered in high transmission settings until better tests are available. In settings with high dengue transmission (high numbers of seropositives), a test with lower specificity might be acceptable.. The pre-test probability of ...
TY - JOUR. T1 - Identification of five interferon-induced cellular proteins that inhibit West Nile virus and dengue virus infections. AU - Jiang, Dong. AU - Weidner, Jessica M.. AU - Qing, Min. AU - Pan, Xiao Ben. AU - Guo, Haitao. AU - Xu, Chunxiao. AU - Zhang, Xianchao. AU - Birk, Alex. AU - Chang, Jinhong. AU - Shi, Pei Yong. AU - Block, Timothy M.. AU - Guo, Ju Tao. PY - 2010/8. Y1 - 2010/8. N2 - Interferons (IFNs) are key mediators of the host innate antiviral immune response. To identify IFN-stimulated genes (ISGs) that instigate an antiviral state against two medically important flaviviruses, West Nile virus (WNV) and dengue virus (DENV), we tested 36 ISGs that are commonly induced by IFN-α for antiviral activity against the two viruses. We discovered that five ISGs efficiently suppressed WNV and/or DENV infection when they were individually expressed in HEK293 cells. Mechanistic analyses revealed that two structurally related cell plasma membrane proteins, IFITM2 and IFITM3, disrupted ...
Dengue disease (DENV) an infection of human beings is presently the main arthropod-borne viral global risk, for which zero suitable or reliable pet model exists. Reviews addressing the result of DENV on vascular elements apart from endothelial cells lack. Dengue virus an infection of vascular even muscle cells, which play a physiological compensatory response to hypotension in arterioles and arteries, is not characterized, hence precluding our knowledge of the function of these vascular parts in dengue pathogenesis. Consequently, we analyzed the permissiveness of main human being umbilical artery clean muscle mass cells (HUASMC) to DENV 1C4 illness and compared with the infection in the previously reported main human being umbilical vein endothelial cells (HUVEC) and the classically used, non-transformed, and highly permissive Lilly Laboratories Cell-Monkey Kidney 2 cells. Our outcomes present that HUASMC are successful and vunerable to an infection using the four DENV serotypes, although to a ...
The Philippines and Thailand share a common history when it comes to dengue because it was in these two countries where the dengue hemorrhagic fever, a lethal complication of dengue fever, was first reported and identified in the 1950s.. Fifty-eight years later, dengue fever has become a major international public health concern considering that majority of those affected are children ages between one and 10 years old.. Hospitalized. Though dengue fever is usually not a fatal disease, young patients are more likely to be hospitalized especially if they develop high fever, severe headache, strain in muscles and rashes.. If left unmanaged, dengue fever could kill up to 20 percent of those infected as the patient develops life-threatening conditions like bleeding, low levels of blood platelets and blood plasma leakage (dengue hemorrhagic fever) and circulatory failure (dengue shock syndrome).. According to Dr. Lyndon Lee Suy, program manager of the Department of Healths Emerging and Reemerging ...
Dengue virus is transmitted by Aedes aegypti and Aedes albopictus as a vector that will carry the virus into the human body through mosquito bites. The first infection can give symptoms as dengue fever. If that person gets repeated infections by different dengue virus type will cause a different reaction. Dengue Haemorrhagic Fever can occur when someone who has been infected with dengue the first time, had recurrent infections of other dengue virus. the virus to replicate in the regional lymph nodes and spread to other tissues, especially the reticuloendothelial system and skin as well as haematogenous bronkogen. The body will form virus-antibody complexes in blood circulation and therefore would lead to activation of the complement system resulting in the release of C3a and C5a anafiloksin thus increased permeability of blood vessel walls. Will occur also release ADP platelet aggregation, thrombocyte vasoaktif release that are increasing capillary permeability and the release of thrombocyte ...
Link to Pubmed [PMID] - 30753180. PLoS Negl Trop Dis 2019 Feb;13(2):e0007116. BACKGROUND: Transmission of dengue virus (DENV) from humans to mosquitoes represents a critical component of dengue epidemiology. Examinations of this process have generally been hampered by a lack of methods that adequately represent natural acquisition of DENV by mosquitoes from humans. In this study, we assessed artificial and natural blood feeding methods based on rates of DENV infection and dissemination within mosquitoes for use in a field-based epidemiological cohort study in Iquitos, Peru.. METHODOLOGY/PRINCIPAL FINDINGS: Our study was implemented, stepwise, between 2011 and 2015. Participants who were 5 years and older with 5 or fewer days of fever were enrolled from ongoing clinic- and neighborhood-based studies on dengue in Iquitos. Wild type, laboratory-reared Aedes aegypti were fed directly on febrile individuals or on blood collected from participants that was either untreated or treated with EDTA. ...
Dengue fever and dengue hemorrhagic fever (DHF) are acute febrile diseases, found in the tropics and Africa, and caused by four closely related virus serotypes of the genus Flavivirus, family Flaviviridae.The geographical spread is similar to malaria, but unlike malaria, dengue is often found in urban areas of tropical nations, including Singapore, Taiwan, Indonesia, Philippines, India and Brazil. Each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. Dengue is transmitted to humans by the Aedes aegypti (rarely Aedes albopictus) mosquito, which feeds during the day.. Dengue (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), of the genus Flavivirus. Infection with one of these serotypes provides immunity to only that serotype for life, so persons living in a dengue-endemic area can have more than ...
Dengue is a viral infection spread by mosquitoes. It is endemic in Malaysia, as it is in most tropical countries. Worldwide, dengue is also the fastest spreading mosquito-borne viral diseases. Symptoms can range from a mild fever to severe dengue fever with bleeding, accumulation of fluid in the lungs and abdomen, shock and death. Dengue doesnt choose who it affects, anybody can get dengue, whether young or old, woman or man. Health clinic staff and doctors would usually advise patients to drink more water if they are suspected to have dengue fever. Whether this is beneficial or not has not been well studied so far. If oral (by mouth) fluid intake is beneficial, the next question is how to improve the delivery of this advice to dengue patients who come to the primary health care clinics. A simple fluid chart has been designed that patients suspected of having dengue fever should complete every day for as long as they are being followed up by their doctor for the condition. The patient with ...
Dengue is fast emerging pandemic-prone viral disease in many parts of the world. Dengue flourishes in urban poor areas, suburbs and the countryside but also affects more affluent neighbourhoods in tropical and subtropical countries.. Dengue is a mosquito-borne viral infection causing a severe flu-like illness and, sometimes causing a potentially lethal complication called severe dengue. The incidence of dengue has increased 30-fold over the last 50 years. Up to 50-100 million infections are now estimated to occur annually in over 100 endemic countries, putting almost half of the worlds population at risk.. Severe dengue (previously known as dengue haemorrhagic fever) was first recognized in the 1950s during dengue epidemics in the Philippines and Thailand. Today it affects Asian and Latin American countries and has become a leading cause of hospitalization and death among children and adults in these regions.. The full life cycle of dengue fever virus involves the role of mosquito as a ...
Selangor is by far the most affected state with it closing in on 20,000 cases, accounting for 60 percent of all cases in the southeast Asian country.. Last week, 75 percent of construction sites inspected were ordered closed for cleaning of Aedes mosquito breeding sites, according to a Sun Daily report Friday.. According to the World Health Organization, dengue is transmitted by the bite of a mosquito infected with one of the four dengue virus serotypes. It is a febrile illness that affects infants, young children and adults withsymptomsappearing 3-14 days after the infective bite. As many as 400 million people areinfectedyearly.. Dengue is not transmitted directly from person-to-person and symptoms range from mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash. There is no vaccine or any specific medicine to treat dengue. People who have dengue fever should rest, drink plenty of fluids and reduce the fever using paracetamol or ...
TY - JOUR. T1 - Tri-phasic fever in dengue fever. AU - Pradeepa, H. D.. AU - Rao, Sathish B.. AU - Ganaraj, B.. AU - Bhat, Gopalakrishna. AU - Chakrapani, M.. PY - 2018/4/1. Y1 - 2018/4/1. N2 - Dengue fever is an acute febrile illness with a duration of 2-12 days. Our observational study observed the 24-h continuous tympanic temperature pattern of 15 patients with dengue fever and compared this with 26 others with fever due to a non-dengue aetiology. A tri-phasic fever pattern was seen among two-thirds of dengue fever patients, but in only one with an inflammatory disease. One-third of dengue fever patients exhibited a single peak temperature. Continuous temperature monitoring and temperature pattern analysis in clinical settings can aid in the early differentiation of dengue fever from non-dengue aetiology.. AB - Dengue fever is an acute febrile illness with a duration of 2-12 days. Our observational study observed the 24-h continuous tympanic temperature pattern of 15 patients with dengue ...
Dengue vaccine development has made significant strides, but a better understanding of how vaccine-induced immune responses correlate with vaccine efficacy can greatly accelerate development, testing, and deployment as well as ameliorate potential risks and safety concerns. Advances in basic immunology knowledge and techniques have already improved our understanding of cell-mediated immunity of natural dengue virus infection and vaccination. We conclude that the evidence base is adequate to argue for inclusion of assessments of cell-mediated immunity as part of clinical trials of dengue vaccines, although further research to identify useful correlates of protective immunity is needed.
Recent dengue outbreaks in the Caribbean and Central and South America and the presence of competent mosquito vectors increase the likelihood of future autochthonous transmission in Florida. During April 1997 to March 1998, a laboratory-based active surveillance program detected 18 cases of dengue involving all four dengue serotypes. All patients reported recent travel to countries with indigenous dengue transmission. These results demonstrate that dengue infections are imported into Florida at a much higher rate than reflected by previous passive surveillance; therefore, the risk for local dengue transmission may be increasing.
A serologic survey by the Centers for Disease Control and Prevention (CDC) suggests that 3% to 5% of residents in the Old Town area of Key West, Fla., had dengue virus infections in the late summer of 2009, according to a report published online today by Emerging Infectious Diseases. The finding shows the potential for the reemergence of dengue virus in subtropical parts of the United States, the authors said. The survey was conducted after a dengue infection was reported in a person who had traveled to Key West. The researches chose 911 households within 1 kilometer of where the index case had stayed; they were able to test 240 residents in 170 households. Thirteen (5%) of the residents tested positive for acute (2), recent (6), or presumptive recent (5) dengue infections. Also, 16 other people had evidence of previous dengue infections, with antibodies against multiple dengue serotypes. Infection was more likely in those who kept windows open more than half the time, had a yard more than half ...
Infection with one virus does not protect a person against infection with another. A person can be infected by at least two, if not all four types of the dengue virus at different times during a life span, but only once by the same type. People contract dengue fever from the bite of an infected Aedes mosquito. Mosquitoes become infected when they bite infected humans, and later transmit infection to others.If not treated properly, dengue hemorrhagic fever may occur. Dengue hemorrhagic fever is severe and often fatal.Dengue fever can be caused by any one of four types of dengue virus:. ...
Geographic expansion of dengue incidence has drawn a global interest to identify the influential factors that instigate the spread of this disease. The objective of this study was to find the environmental factors linked to dengue incidence in a dengue epidemic area of Nepal by negative binomial models using climatic factors from 2010 to 2017. Minimum temperature at lag 2 months, maximum temperature and relative humidity without lag period significantly affected dengue incidence. Rainfall was not associated with dengue incidence in Chitwan district of Nepal. The incident rate ratio (IRR) of dengue case rise by more than 1% for every unit increase in minimum temperature at lag 2 months, maximum temperature and relative humidity, but decrease by .759% for maximum temperature at lag 3 months. Considering the effect of minimum temperature of previous months on dengue incidence, the vector control and dengue management program should be implemented at least 2 months ahead of dengue outbreak season.
We all hear about the rising cases of dengue, chikungunya, malaria due to the breeding of mosquitoes in the monsoon season. According to the civic bodies, the National Capital Region has reported 284 new dengue cases in the last ten days, taking the total to 771. There were around 50,000 dengue cases which were reported last year.. India has observed a 14 times increase in the number of dengue cases reported between 2007 and 2013 (as per National Vector Borne Disease Control Programme) with symptoms that require hospitalisation for its treatment. Such rise in dengue cases has resulted in an increase in the health insurance claims in past years as per the insurers.. What is dengue?. Dengue or break-bone fever is a mosquito-borne viral disease which is mainly found in the tropical and subtropical countries. This disease is caused by one of the four related dengue viruses and is an infectious disease. It is a life-threatening disease, and there is no vaccination or drug available to cure the ...
Dengue (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), of the genus Flavivirus. Infection with one of these serotypes provides immunity to only that serotype for life, so persons living in a dengue-endemic area can have more than one dengue infection during their lifetime. DF and DHF are primarily diseases of tropical and sub tropical areas, and the four different dengue serotypes are maintained in a cycle that involves humans and the Aedes mosquito. However, Aedes aegypti, a domestic, day-biting mosquito that prefers to feed on humans, is the most common Aedes species. Infections produce a spectrum of clinical illness ranging from a nonspecific viral syndrome to severe and fatal hemorrhagic disease. Important risk factors for DHF include the strain of the infecting virus, as well as the age, and especially the prior dengue infection history of the patient ...
Abstract. Dengue virus (DENV) infection usually presents with mild self-limiting dengue fever (DF). Few however, would present with the more severe form of the disease, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). In the present study, the association between IL-12B, IL-10 and TNF-α gene polymorphisms and dengue severity was investigated. Methods: A case-control study was performed on a total of 120 unrelated controls, 86 DF patients and 196 DHF/DSS patients. The polymorphisms in IL-12B, IL-10 and TNF-α genes were genotyped using PCR-RFLP and PCR-sequencing methods. Results: A protective association of TNF-α -308A allele and -308GA genotype against DHF/DSS was observed, while TNF-α -238A allele and -238GA genotype were associated with DHF/DSS. A combination of TNF-α -308GA+AA genotype and IL-10 non-GCC haplotypes, IL-12B pro homozygotes (pro1/pro1, pro2/pro2) and IL-12B 3UTR AC were significantly correlated with protective effects against DHF/DSS. An association between ...
The rapid spread of dengue is a worldwide public health problem. In two clinical studies of dengue in Managua, Nicaragua, we observed an abrupt increase in disease severity across several epidemic seasons of dengue virus serotype 2 (DENV-2) transmission. Waning DENV-1 immunity appeared to increase the risk of severe disease in subsequent DENV-2 infections after a period of cross-protection. The increase in severity coincided with replacement of the Asian/American DENV-2 NI-1 clade with a new virus clade, NI-2B. In vitro analyses of viral isolates from the two clades and analysis of viremia in patient blood samples support the emergence of a fitter virus in later, relative to earlier, epidemic seasons. In addition, the NI-1 clade of viruses was more virulent specifically in children who were immune to DENV-1, whereas DENV-3 immunity was associated with more severe disease among NI-2B infections. Our data demonstrate that the complex interaction between viral genetics and population dynamics of ...
Dengue is a mosquito-borne disease caused by the dengue viruses. There are four distinct but related virus serotypes all of which can cause dengue fever or the more serious forms of the disease, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS).
The Brazilian Ministry of Health has reported 746,000 registered cases of Dengue fever and 229 confirmed deaths since January 2015 [1,3]. This marks a 234% increase in Dengue cases and a 45% increase in Dengue deaths since the previous year [3]. Although nine states are currently experiencing an outbreak of Dengue, more than half of these cases occurred in São Paulo, which also happens to be Brazils most populous state [1]. To date, São Paulo has had three times as many Dengue cases as there were reported in 2014 [1].. Dengue Fever. Dengue fever is a viral disease transmitted to humans through the bite of an infected female mosquito [1-5]. Dengue can be found in tropical and sub-tropical climates across the globe, primarily in urban and semi-urban areas [5]. This places about half of the worlds population at risk [5]. The incubation period for Dengue fever is 4 to 10 days [5]. Symptoms last about 2 to 7 days and include: high fever, severe headache, pain behind the eyes, muscle and joint ...
Despite its heavy toll, the prevention and clinical treatment of dengue infection has been a dramatic failure in public health compared to other infectious diseases like HIV, said Ping Liu of the University of North Carolina at Chapel Hill. Now, new research by Liu and her colleagues could offer vital insight into the mechanism of dengue virus entry into cells -- and aid vaccine and clinical drug development.
Dengue viruses are members of the Flaviviridae, transmitted principally in a cycle involving humans and mosquito vectors. In the last 20 years the incidence of dengue fever epidemics has increased and hyperendemic transmission has been established over a geographically expanding area. A severe form, dengue hemorrhagic fever (DHF), is an immunopathologic disease occurring in persons who experience sequential dengue infections. The risk of sequential infections, and consequently the incidence of DHF, has risen dramatically, first in Asia and now in the Americas. At the root of the emergence of dengue as a major health problem are changes in human demography and behavior, leading to unchecked populations of and increased exposure to the principal domestic mosquito vector, Aedes aegypti. Virus-specified factors also influence the epidemiology of dengue. Speculations on future events in the epidemiology, evolution, and biological expression of dengue are presented.. ...
Dengue is a mosquito-borne infectious disease caused by the dengue virus, which is mainly found in the tropical regions. This is transmitted by the bite of an infected female Aedes mosquito. Dengue fever is caused by one of four different but related viruses. There are four distinct serotypes of the dengue virus (DEN 1, DEN 2, DEN 3 and DEN 4). Dengue is not contagious and does not spread from person to person by physical contact. Dengue fever can occur to people of all ages. Children usually have a milder disease than adults.
Carod-Artal FJ, Wichmann O, Farrar J, Gascón J (September 2013). "Neurological complications of dengue virus infection". The ... Two other herpesviruses (Epstein-Barr virus/HHV-4 and varicella zoster virus/HHV-3) and the bacterium Mycoplasma pneumoniae ... The tropical viral infection dengue fever and Zika virus have also been associated with episodes of GBS.[12][13] Previous ... Some cases may be triggered by the influenza virus and potentially influenza vaccine. An increased incidence of Guillain-Barré ...
Interaction of CLEC5A and dengue virus also induces osteolytic activity.[8] Another pathogen is influenza virus and its ... The most known ligand for CLEC5A is dengue virus (DV). Activated CLEC5A by binding to the dengue virion leads to ... CLEC5A is responsible for dengue virus induced hemorrhagic fever (DHF) and dengue shock syndrome (DSS), which is the most ... May 2008). "CLEC5A is critical for dengue-virus-induced lethal disease". Nature. 453 (7195): 672-6. Bibcode:2008Natur.453..672C ...
"The Incubation Periods of Dengue Viruses". PLOS ONE. 7 (11): e50972. Bibcode:2012PLoSO...750972C. doi:10.1371/journal.pone. ... "Dengue and dengue hemorrhagic fever". Clinical Microbiology Reviews. 11 (3): 480-96. doi:10.1128/CMR.11.3.480. PMC 88892. PMID ... With respect to viral infections, in incubation the virus is replicating.[2] This is in contrast to viral latency, a form of ... Kahn, James O.; Walker, Bruce D. (1998). "Acute Human Immunodeficiency Virus Type 1 Infection". New England Journal of Medicine ...
Dengue virus group Dengue virus Japanese encephalitis virus group Japanese encephalitis virus Murray Valley encephalitis virus ... Louis encephalitis virus West Nile virus Spondweni virus group Spondweni virus Zika virus Yellow fever virus group Yellow fever ... virus Tick-borne viruses Mammalian tick-borne virus group Kyasanur forest disease virus Tick-borne encephalitis virus Family ... virus Bluetongue disease virus Epizootic hemorrhagic disease virus Equine encephalosis virus Genus Seadornavirus Banna virus ...
"A physical interaction network of dengue virus and human proteins". Molecular & Cellular Proteomics. 10 (12): M111.012187. doi: ... The herpes simplex virus-derived AD, VP16 and yeast Gal4 AD have been used with success in yeast[1] whilst a portion of the α- ...
Dengue and chikungunya fever[edit]. Main article: Dengue fever. There are 50-100 million dengue virus infections annually.[25] ... The virus was first isolated from an outbreak in Tanzania in 1952.[26] Chikungunya virus is a member of the genus Alphavirus ... "Dengue Control". Retrieved 12 March 2014.. *^ a b c Pialoux, Gilles; Gaüzère, Bernard-Alex; Jauréguiberry, Stéphane; Strobel, ... No treatment for either dengue or severe dengue exists beyond palliative care.[25] The symptoms are high fever and flu-like ...
"Dengue Virus: Vector And Transmission". 2009-08-07. Retrieved 19 October 2012. "Lay Your Eggs Here". Newswise, Inc. July 3, ... Australia Aedes aegypti and dengue fever United States CDC page on dengue fever containing information on prevalence of Aedes ... Signs of Zika virus-capable mosquito populations have been found adapting for persistence in warm temperate climates. Such a ... "Aedes aegypti and dengue fever". Onview.net Ltd, Microscopy-UK. Retrieved 2010-08-27. McBride, Carolyn S.; Baier, Felix; Omondi ...
"Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by ... Murthy claimed 1BEF could be used as a potential treatment option for patients with dengue and other flaviviral proteases. The ... These papers covered a range of topics; everything from dengue to Taq DNA polymerase. The UAB investigation turned up ...
Zika Virus and Dengue Virus); first aid training; and sanitation improvement. Community engagement is strongly pushed, and ...
It is used extensively in hepatitis C and dengue virus research. Huh7 cells have been instrumental in hepatitis C research. ... "The medicinal chemistry of dengue virus". Journal of Medicinal Chemistry. 59 (12): 5622. doi:10.1021/acs.jmedchem.5b01653. PMID ... The introduction of the Huh7 cell line permitted screening of drug candidates against laboratory-cultured hepatitis C virus and ... Bartenschlager, R; Pietschmann, T (2005). "Efficient hepatitis C virus cell culture system: what a difference the host cell ...
... s are also the initial target of the virus that causes Dengue fever during its development. During ageing the ... Martina BE, Koraka P, Osterhaus AD (October 2009). "Dengue virus pathogenesis: an integrated view". Clinical Microbiology ... Fausch, Steven C.; Da Silva, Diane M.; Rudolf, Michael P.; Kast, W. Martin (2002-09-15). "Human papillomavirus virus-like ... High-risk human papillomaviruses (HPV) are sexually transmitted viruses causally associated with several cancers including ...
The tropical flaviviral infections dengue fever and Zika virus have also been associated with episodes of GBS. Previous ... Carod-Artal FJ, Wichmann O, Farrar J, Gascón J (September 2013). "Neurological complications of dengue virus infection". The ... Two other herpesviruses (Epstein-Barr virus/HHV-4 and varicella zoster virus/HHV-3) and the bacterium Mycoplasma pneumoniae ... The 2009 flu pandemic vaccine against pandemic swine flu virus H1N1/PDM09 did not cause a significant increase in cases. In ...
"Mosquito bite delivery of dengue virus enhances immunogenicity and pathogenesis in humanized mice". Journal of Virology. 86 (14 ... Severe dengue can be fatal, but with good treatment, fewer than 1% of patients die from dengue.[88] Work published in 2012 from ... Viral diseases, such as yellow fever, dengue fever, and chikungunya, transmitted mostly by Aedes aegypti. Dengue fever is the ... WHO (2009). Dengue Guidelines for Diagnosis, Treatment, Prevention and Control (PDF). Geneva: World Health Organization. ISBN ...
December 2009). "An adenosine nucleoside inhibitor of dengue virus". Proceedings of the National Academy of Sciences of the ... West Nile virus, yellow fever virus, Powassan virus, hepatitis C virus, Kyasanur Forest disease virus, Omsk hemorrhagic fever ... for flavivirus infections and shows broad spectrum antiviral activity against many related viruses such as dengue virus, ... virus, and Zika virus. However, NITD008 proved too toxic in pre-clinical animal testing to be suitable for human trials, but it ...
"An adenosine nucleoside inhibitor of dengue virus". Proc Natl Acad Sci U S A. 106 (48): 20435-39. Bibcode:2009PNAS..10620435Y. ... The 7-deaza-adenosine analog has been shown to inhibit the replication of the hepatitis C virus. BCX4430 is protective against ... adenosine analog NITD008 has been reported to directly inhibit the recombinant RNA-dependent RNA polymerase of the dengue virus ... "A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic ...
Yellow fever viruses, Dengue fever viruses, and Zika viruses are of the Flavivirus genera and Chikungunya virus is of the ... Dengue fever: The Dengue virus is a flavivirus also transmissible by Aedes mosquito vectors to other animal hosts. Dengue was ... were found with antibodies dengue viruses 1 and 2 while sloths (Bradypus torquatus) had antibodies for dengue virus 3 therefore ... A 2009 study in French Guiana found that infections of dengue viruses types 1 through 4 were present in various different types ...
In April 2016, Figueroa contracted dengue virus. He was isolated at home to avoid contagion, before returning to training with ... "Alarma en el Fortín: Un jugador de Vélez tiene dengue". Nuevo Diario. 5 April 2016. Retrieved 20 May 2019. "El renovado Vélez ... "Figueroa, el arquero de Vélez, padece dengue". ESPN. 5 April 2016. Retrieved 20 May 2019. "El tercer arquero de Vélez fue ... "Figueroa, arquero del plantel de Vélez tiene dengue". TyC Sports. 5 April 2016. Retrieved 20 May 2019. " ...
Finally, lipid droplets are known to be exploited by pathogens such as the hepatitis C virus, the dengue virus and chlamydia ... Heaton, N.S.; Randall, G (2010). "Dengue virus-induced autophagy regulates lipid metabolism". Cell Host Microbe. 8 (5): 422-32 ...
"Inhibition of interferon signaling by dengue virus". Proceedings of the National Academy of Sciences. 100 (24): 14333-14338. ... "Vaccination of Pigs against Swine Influenza Viruses by Using an NS1-Truncated Modified Live-Virus Vaccine". Journal of Virology ... "An enzymatic virus-like particle assay for sensitive detection of virus entry". Journal of Virological Methods. 163 (2): 336- ... "Inhibition of Interferon-Mediated Antiviral Responses by Influenza a Viruses and Other Negative-Strand RNA Viruses". Virology. ...
Values for both locations were seen to be similar to those found for dengue and Chikungunya virus. Determining these values ... Aedes aegypti and dengue fever. *United States CDC page on dengue fever containing information on prevalence of Aedes aegypti ... Aedes aegypti, the yellow fever mosquito, is a mosquito that can spread dengue fever, chikungunya, Zika fever, Mayaro and ... by the endosymbiotic bacteria allows mosquitos to be resistant to the certain arboviruses such as dengue fever and Zika virus ...
The genus includes human pathogens like Zika virus, West-Nile virus, Dengue virus, Yellow Fever virus and other. The 5' UTR of ... is a critical determinant of dengue virus and West Nile virus RNA synthesis". Virology. 379 (2): 314-323. doi:10.1016/j.virol. ... "Functional RNA Elements in the Dengue Virus Genome". Viruses. 3 (9): 1739-1756. doi:10.3390/v3091739. ISSN 1999-4915. PMC ... Filomatori, C. V. (2006-08-15). "A 5' RNA element promotes dengue virus RNA synthesis on a circular genome". Genes & ...
The genus includes human pathogens like Zika virus, West-Nile virus, Dengue virus, Yellow Fever virus and other. The 3' UTR ... Romero, T. A.; Tumban, E.; Jun, J.; Lott, W. B.; Hanley, K. A. (2006-11-01). "Secondary structure of dengue virus type 4 3' ... Villordo, Sergio M.; Gamarnik, Andrea V. (2013-08-01). "Differential RNA sequence requirement for dengue virus replication in ... Mutations of sHP are shown to be lethal for Dengue virus in mosquito cells. CRE is highly involved in the 5'-3' UTR interaction ...
Chinikar, S., et al., Preliminary study of dengue virus infection in Iran. Travel Medicine and Infectious Disease, 2013. 11(3 ... Chinikar, S., et al., Seroprevalence of West Nile Virus in Iran. Vector-Borne and Zoonotic Diseases, 2013. 13(8): p. 586-589. ... Sureau, P., et al., Isolation of Thogoto, Wad Medani, Wanowrie and Crimean-Congo haemorrhagic fever viruses from ticks of ... Mehravarana Ahmad , et al., Molecular detection of Crimean-Congo haemorrhagic fever (CCHF) virus in ticks from southeastern ...
"Laboratory-acquired dengue virus infection by needlestick injury: A case report, South Korea, 2014". Retrieved 2021-02-13. " ... "Laboratory-Acquired Dengue Virus Infection-A Case Report". PLOS Neglected Tropical Diseases. Journals.plos.org. 5 (11): e1324. ... 2014, a 30-year-old female laboratory worker in South Koera working at a BSL-2 was infected with Dengue through a needlestick ... April 2018 - Ebola from a laboratory accident led to a single worker being exposed to the Ebola virus, though he did not ...
It is a vector for the dengue virus. "WRBU: Aedes scutellaris". Archived from the original on 2010-06-23. CS1 maint: ... "Infection and dissemination of dengue virus type 2 in Aedes aegypti, Aedes albopictus, and Aedes scutellaris from the Torres ...
Abdel-Magid, Ahmed F. (2017-01-12). "Viral Replication Inhibitors May Treat the Dengue Virus Infections". ACS Medicinal ...
... cross-reactivity with dengue virus and tick-borne encephalitis virus". J. Med. Virol. 83 (10): 1861-5. doi:10.1002/jmv.22180. ... It is common in serologic testing for cross-reactions to occur among flaviviruses such as dengue virus (DENV) and tick-borne ... This structure is similar to the dengue fever virus; both belong to the genus Flavivirus within the family Flaviviridae. The ... The virus is believed to have entered in an infected bird or mosquito, although there is no clear evidence. West Nile virus is ...
Gadgets Gully virus (GGYV), FSME-Virus - en. Tick-borne encephalitis virus (TBEV), Dengue-Virus - en. Dengue virus (DENV), St.- ... Usutu-Virus - en. Usutu virus (USUV), Zika-Virus - en. Zika virus (ZIKV), sowie Gelbfieber-Virus - en. Yellow fever virus (YFV) ... Genus ‚Negevirus', mit Species ‚Blackford virus', ‚Bofa virus', ‚Buckhurst virus', ‚Marsac virus', sowie ‚Muthill virus'[53] ... Sorghum mosaic virus (SrMV), Lily-Mottle-Virus - en. Lily mottle virus (LMoV), sowie Sellerie-Virus Y - en. Apium virus Y (ApVY ...
The four are Bundibugyo virus (BDBV), Sudan virus (SUDV), Taï Forest virus (TAFV) and one simply called Ebola virus (EBOV, ... Early symptoms of EVD may be similar to those of other diseases common in Africa, including malaria and dengue fever.[25] The ... The virus responsible for the initial outbreak, first thought to be Marburg virus, was later identified as a new type of virus ... Main articles: Ebola virus cases in the United States, Ebola virus disease in Spain, and Ebola virus disease in the United ...
Lujo virus. References[edit]. *^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad "Lassa fever". WHO. March 2016 ... Usutu virus. *West Nile fever *WNV. *Viral hemorrhagic fevers: Dengue fever *DENV-1-4 ... Confirmation is by laboratory testing to detect the virus's RNA, antibodies for the virus, or the virus itself in cell culture. ... The Lassa virus is one of several viruses identified by WHO as a likely cause of a future epidemic. They therefore list it for ...
"Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries.", Virol. J., 7 (52). ... Singaporean dengue (2005). *Indian dengue (2006). *Chikungunya outbreaks (2006). *Pakistani dengue (2006) ... "Origin of the Measles Virus: Divergence from Rinderpest Virus Between the 11th and 12th Centuries". Virology. 7: 52-55. doi ...
Since these tests can cross-react with other flaviviruses, such as dengue virus, these indirect methods cannot conclusively ... Other viral hemorrhagic fevers, such as Ebola virus, Lassa virus, Marburg virus, and Junin virus, must be excluded as the cause ... That immunity is present in the populations because of other diseases caused by related viruses (for example, dengue). ... Viruses reach the stomach of the mosquito, and if the virus concentration is high enough, the virions can infect epithelial ...
Anthrax is now known to be caused by a bacterium, and rabies is known to be caused by a virus. The microscopes of the time ... a virus, or a prion. At present, the science to understand this process is available but not the technology to perform it.[25] ... could reasonably be expected to show bacteria, but imaging of viruses had to wait until the development of electron microscopes ...
4.0 4.1 Rodenhuis-Zybert IA, Wilschut J, Smit JM (August 2010). "Dengue virus life cycle: viral and host factors modulating ... "Chapter 5 - dengue fever (DF) and dengue hemorrhagic fever (DHF)". 2010 Yellow Book. பார்த்த நாள் 2010-12-23. ... "Dengue". World Health Organization. பார்த்த நாள் 27 June 2011.. *"Dengue". U.S. Centers for Disease Control and Prevention. ... "Dengue virus pathogenesis: an integrated view". Clin. Microbiol. Rev. 22 (4): 564-81. doi:10.1128/CMR.00035-09. பப்மெட்: ...
This worldwide biomedical research organization based in Paris was the first to isolate HIV, the virus that causes AIDS, in ... dengue fever and the Shigella bacterium. ... Félix d'Herelle discovered in 1917 the bacteriophage, a virus ... One area of particular interest is the study of human papilloma viruses (HPV) and their role in cervical cancers. Researchers ... Luc Montagnier, Françoise Barré-Sinoussi and colleagues discovered the two HIV viruses that cause AIDS, in 1983 and 1985, was ...
Flavivirus: Akhurma virus,[13]Dengue,[14] Hepatit C, Kyasanur Forest disease virus,[15] Omsk hemorrhagic fever virus,[15] Sarı ... Arenavirus: Guanarito virus,[2] Junín virus,[2] Lassa fever virus,[2] Lujo virus,[3] Machupo virus[2] ve Sabiá virus[2] ... Hantaan virus,[6] Puumala virus,[7] Rift Valley fever virus,[8] Seoul virus[9] ve SFTS virus[10] ... Herpesvirus: Cytomegalovirus,[17] Epstein Barr virus,[18] Varicella zoster virus, Human herpesvirus 6, Human herpesvirus 7 ve ...
Eastern equine encephalitis virus, Venezuelan equine encephalitis virus, Western equine encephalitis virus horses, donkeys, ... Other haemorrhagic fevers (Crimean-Congo haemorrhagic fever, Dengue fever, Lassa fever, Marburg viral haemorrhagic fever, Rift ... Kyasanur Forest disease virus rodents, shrews, bats, monkeys tick bite La Crosse encephalitis La Crosse virus chipmunks, tree ... Barmah Forest virus kangaroos, wallabies, opossums mosquito bite Bird flu Influenza A virus subtype H5N1 wild birds, ...
The dengue virus also inhibits type I IFN production by blocking IRF-3 phosophorylation using NS2B3 protease complex.[27] ... Some viruses evade this by producing molecules which interfere with IFN production. For example, the Influenza A virus produces ... "Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active ... Viruses[edit]. Type I interferons (IFN), secreted mainly by dendritic cells,[22] play a central role in antiviral host defense ...
In virus classification, influenza viruses are RNA viruses that make up four of the seven genera of the family Orthomyxoviridae ... Symptoms in 1918 were so unusual that initially influenza was misdiagnosed as dengue, cholera, or typhoid. One observer wrote ... These viruses are only distantly related to the human parainfluenza viruses, which are RNA viruses belonging to the ... The virus has the potential to infect humans, although no such cases have been observed yet.[7] This virus has not been found ...
... it is now thought some chikungunya and dengue cases could in fact be zika virus cases or coinfections. ... It is a member of the Semliki Forest virus complex and is closely related to Ross River virus, O'nyong'nyong virus, and Semliki ... and false positives can occur with infection due to other related viruses, such as o'nyong'nyong virus and Semliki Forest virus ... Chikungunya virus is passed to humans when a bite from an infected mosquito breaks the skin and introduces the virus into the ...
Talk:2013 dengue outbreak in Singapore. *Talk:2013 Huangpu River dead pigs incident ... Pages in category "Low-importance virus articles". The following 200 pages are in this category, out of approximately 1,493 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Category:Low-importance_virus_articles&oldid=388350164" ...
A respiratory syncytial virus vaccine (RSV vaccine) is a vaccine which prevents infection by respiratory syncytial virus. No ... Mejias, Asuncion; Rodriguez-Fernandez, Rosa; Peeples, Mark E.; Ramilo, Octavio (October 2019). "Respiratory Syncytial Virus ... "Respiratory syncytial virus vaccines". Clinical Microbiology Reviews. 11 (3): 430-9. doi:10.1128/CMR.11.3.430. PMC 88889. PMID ... "The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates" (PDF). The Lancet ...
... classical dengue). *(A91.) Dengue haemorrhagic fever. *(A92.) Other mosquito-borne viral fevers *(A92.0) Chikungunya virus ... B20-B24) Human immunodeficiency virus (HIV) disease[संपादित करें]. *(B20.) Human Immunodeficiency Virus (HIV) disease Resulting ... B24.) Unspecified Human Immunodeficiency Virus (HIV) Disease. (B25-B34) Other viral diseases[संपादित करें]. *(B25.) ... B21.) Human Immunodeficiency Virus (HIV) disease Resulting in malignant neoplasms *(B21.0) HIV disease resulting in Kaposi's ...
Dengue. *Ebola. *Epstein-Barr virus. *Hepatitis C. *HIV. Protozoan. *Malaria *RTS,S ...
The fifth reassortant virus expresses the attachment protein VP4, (type P1A), from the human rotavirus parent strain and the ... Rotavirus antigens for parenteral delivery, such as the P2-VP8 candidate, can be expressed as virus-like particles prepared in ... Both are taken orally and contain disabled live virus. ... and killed virus. These novel approaches are being pursued ...
dengue fever [84]. India 2006 Chikungunya outbreaks Chikungunya virus [85]. , 50 Pakistan 2006 2006 dengue outbreak in Pakistan ... 2015-16 Zika virus epidemic Zika virus. Hundreds (as of 1 April 2016[update]) Africa 2016 2016 yellow fever outbreak in Angola ... 2018 Nipah virus outbreak Nipah virus infection 1,743 (as of 21 July 2019[update]) Democratic Republic of the Congo & Uganda ... 2011 dengue outbreak in Pakistan dengue fever. 847 (as of 10 January 2013[update]) Darfur Sudan 2012 2012 yellow fever outbreak ...
Dengue. *Ebola. *Epstein-Barr virus. *Hepatitis C. *HIV. Protozoan. *Malaria *RTS,S ...
This virus-related article is a stub. You can help Wikipedia by expanding it. *v ... The first hantavirus vaccine was developed in 1990 initially for use against Hantaan River virus which causes one of the most ... They include a recombinant vaccine and vaccines derived from HTNV and PUUV viruses. However, their prospects are unclear.[1] ... Other hantaviruses for which the vaccine is used include Seoul (SEOV) virus. However the vaccine is thought not to be effective ...
Other viruses such as SARS, polio, Ebola, measles, human coxsackie, Dengue, rabies, human hepatitis, human parainfluenza and ... However, these methods are proving to be ineffective due to the development of resistant strains of the virus or due to the ... By inhibiting the function of NCp7, the viral replication is affected and a non-functional virus that is unable to infect its ... NV038 is found to effect the function of the zinc finger after the virus has entered the cell but before reverse transcription ...
Some viruses once acquired never leave the body. A typical example is the herpes virus, which tends to hide in nerves and ... Tropical diseases include Chagas disease, dengue fever, lymphatic filariasis, leishmaniasis, onchocerciasis, schistosomiasis ... Viruses are also usually identified using alternatives to growth in culture or animals. Some viruses may be grown in ... Pathogenic viruses. Pathogenic bacteria Pathophysiology[edit]. There is a general chain of events that applies to infections.[ ...
Ebola virus disease → 에볼라 출혈열 (B+). *Hand, foot and mouth disease → 수족구병 (C) ... Dengue fever → 뎅기열 (B). *Diphtheria → 디프테리아 (E). *Dysentery → 이질 (D). *Encephalitis → 뇌염 (E) ...
Dengue. *Ebola. *Epstein-Barr virus. *Hepatitis C. *HIV. Protozoan. *research: *Malaria. *Trypanosomiasis ...
1K4R This entry displays a dengue virus envelope protein but the source organism is HIV???, and the annotation copy/pasted from ... WikiProject Viruses. (Rated Stub-class, High-importance). VirusesWikipedia:WikiProject VirusesTemplate:WikiProject Virusesvirus ... This article is within the scope of WikiProject Viruses, a collaborative effort to improve the coverage of viruses on Wikipedia ...
... dengue fever, Ross River virus and food-borne infections such as Salmonellosis) may be among the first detectable impacts of ... Outbreaks of a number of diseases, including Lyme disease, hantavirus infections, dengue fever, bubonic plague, and cholera, ...
Usutu virus. *West Nile fever *WNV. *Viral hemorrhagic fevers: Dengue fever *DENV-1-4 ... Lassa viruses[12][13] are enveloped, single-stranded, bisegmented, ambisense RNA viruses. Their genome[14] is contained in two ... Lassa virus is an emerging virus and a select agent, requiring Biosafety Level 4-equivalent containment. It is endemic in West ... The life cycle of Lassa virus is similar to the Old World arenaviruses. Lassa virus enters the cell by the receptor-mediated ...
Increased frequencies of CD4+ CD25(high) regulatory T cells in acute dengue infection. „J Exp Med". 204 (5), s. 979-985, maj ... Tregs control the development of symptomatic West Nile virus infection in humans and mice. „J Clin Invest". 119 (11), s. 3266- ...
Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever ... Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). ... Immunologic hypo- or non-responder in natural dengue virus infection Serologically defined primary dengue virus infection and/ ... Dengue virus infection induces autophagy: an in vivo study We and others have reported that autophagy is induced by dengue ...
Dengue virus, dengue hemorrhagic fever, dengue fever, flavivirus, Aedes mosquitoes, DHF, DF, DSS ... to determine the likelihood that the current or recent illness is due to an infection with dengue virus. ...
Dengue virus, dengue hemorrhagic fever, dengue fever, flavivirus, Aedes mosquitoes, DHF, DF, DSS ... NS1 tests detect the non-structural protein NS1 of dengue virus. This protein is secreted into the blood during dengue ... NS1 is detectable during the acute phase of dengue virus infections. NS1 tests can be as sensitive as molecular tests during ... A positive NS1 test result confirms dengue virus infection without providing serotype information. ...
Virus Sections. Virus Name/Prototype. Original Source. Method of Isolation. Virus Properties. Antigenic Relationship. Biologic ... Classical dengue with rash after appropriate incubation in first and subsequent volunteers and Ae aegypti transmission.** ... Click on the PDF icon to the left to view a copy of this virus entry in PDF format. You can get a copy of the PDF viewer by ...
Virus Sections. Virus Name/Prototype. Original Source. Method of Isolation. Virus Properties. Antigenic Relationship. Biologic ... Arthropod species & virus source(a) Method of Infection log10/ml (b) Incubation period (c) Transmision by bite (d) Assay of ... Click on the PDF icon to the left to view a copy of this virus entry in PDF format. You can get a copy of the PDF viewer by ... Experimental transmission successful following feeding on mouse brain virus or viremic animal ...
Abbreviations: DEN, dengue virus; ISRE, IFN-stimulated response element; FL, firefly luciferase; NDV, Newcastle disease virus; ... Inhibition of interferon signaling by dengue virus. Jorge L. Muñoz-Jordán, Gilma G. Sánchez-Burgos, Maudry Laurent-Rolle, ... Inhibition of interferon signaling by dengue virus. Jorge L. Muñoz-Jordán, Gilma G. Sánchez-Burgos, Maudry Laurent-Rolle, ... Although dengue virus-infected cells seem to be resistant to the antiviral action of IFN, the viral products that mediate this ...
dengue virus mechanism list drugs cause. dengue virus mechanism list drugs interactions. dengue virus mechanism list drugs ... How Dengue Virus Infects Cells , National Institutes of .... www.nih.gov/.../how-dengue-virus-infects-cells ... How Dengue Virus Infects Cells. Researchers have discovered a key step in how the dengue virus infects a cell. The finding will ... 2. Prior infection with a dengue fever virus.Previous infection with a dengue fever virus increases your risk of having severe ...
The development marks the first engineered approach in mosquitoes that targets the four known types of dengue, improving upon ... An international team of scientists has synthetically engineered mosquitoes that halt the transmission of the dengue virus. ... dengue virus threatens millions of people in tropical and sub-tropical climates. Severe dengue is a leading cause of serious ... Mosquitoes Engineered to Repel Dengue Virus. Researchers develop the first mosquitoes synthetically designed to neutralize many ...
dengue virus symptoms and cure treatment over the counter. dengue virus symptoms and cure treatment home remedies. dengue virus ... Dengue virus (DENV) is the cause of dengue fever.It is a mosquito-borne, single positive-stranded RNA virus of the family ... dengue virus symptoms and cure treatment mayo clinic. dengue virus symptoms and cure treatment psoriasis. ... dengue virus symptoms and cure treatment antibiotics. dengue virus symptoms and cure treatment copd. ...
Mouse STAT2 restricts early dengue virus replication.. Ashour J1, Morrison J, Laurent-Rolle M, Belicha-Villanueva A, Plumlee CR ... Dengue virus encodes several interferon antagonists. Among these the NS5 protein binds STAT2, a necessary component of the type ... By using STAT2(-/-) mice, we also demonstrate that mouse STAT2 restricts early dengue virus replication in vivo. These results ... Virus replication levels were recorded 12hpi by live microscopy. B. U6A cells or U6A-hSTAT2-FLAG or U6A-mSTAT2-FLAG cells were ...
Care guide for Dengue Virus. Includes: possible causes, signs and symptoms, standard treatment options and means of care and ... What is dengue virus?. Dengue virus is carried by mosquitos. Dengue virus may cause a mild to severe viral infection. ... Dengue virus may be passed from a mother to her unborn baby. You may be at risk for dengue virus if you travel or live in an ... How can I help prevent the spread of dengue virus?. There is currently no vaccine to prevent Dengue virus. Do not travel to ...
Entry of the dengue virus in the presence of dominant negative mutants of Eps15. Examples of cells positive for both dominant ... Simultaneous inhibition of macropinocytosis and clathrin mediated endocytosis in HepG2 cells and infection with dengue virus ... followed by infection with each dengue virus serotype individually or Alexa 594 conjugated-transferrin. Dengue infected samples ... Effects of biochemical inhibitors of endocytosis on dengue virus entry. HepG2 cells were pre-incubated with cytochalasin D (C ...
Some people who fell prey to a 2009-2010 outbreak of dengue fever in Florida carried a particular viral strain that they did ... "So, there is potential for the dengue virus to be transmitted locally, and cause dengue outbreaks like the ones we saw in Key ... "Every year more countries add another one of the dengue virus subtypes to their lists of locally transmitted viruses, and this ... home/infectious disease center/ infectious disease a-z list/ homegrown strain of dengue fever virus pinpointed article ...
Articles on viral structure, function, and genetics will be considered, as well as articles focusing on virus-host interactions ... and clinical studies on viruses and viral diseases. ... HPMEC-ST1.6R infected with dengue-2 and dengue-3 virus," ... "Animal models of dengue virus infection and disease: applications, insights and frontiers," in Frontiers in Dengue Virus ... levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue ...
... the combination of the defective virus with the normal virus was "more fit" than the normal dengue virus alone. ... Dengue is a disease transmitted by mosquitoes and caused by four types of the dengue virus. Infection may not result in ... Defective viruses: disease transmitters beyond dengue?. Might defective viruses play a role in the transmission of the flu, ... It takes two (viruses) to tango. The functional virus and defective virus travel in unison. The two transmit together in an ...
La Jolla Institute scientists have proved a hypothesis that said antibodies contribute to severe dengue virus-induced disease. ... Dengue. Dengue is a tropical disease caused by mosquitoes carrying the dengue virus. Symptoms include fever, joint & muscle ... Chicken Pox Dengue Fever Dengue / Dengue Hemorrhagic Fever Mosquito Diseases Shigellosis Dengue and Homeopathy Chikungunya and ... Dengue / Dengue Hemorrhagic Fever. Encyclopedia section of medindia gives general information about Dengue and Dengue ...
Dengue Fever is one of the most common tropical diseases transmitted by mosquitoes, and its spreading ... to collectors ... Dengue Fever (Dengue virus). Dengue Fever (Dengue virus) GMEU-PD-0180 £8.95 ... All about Dengue Fever (Dengue virus). FACTS: Dengue fever is a tropical disease endemic to more than 100 countries. Up to a ... In addition, because Dengue virus attacks white blood cells and can compromise platelet production, it can also cause the ...
... of the dengue virus interacts with another viral protein called NS4A-2K-4B to enable viral replication, according to a study ... Dengue virus is one of the most prevalent mosquito-transmitted human pathogens. Despite the serious socio-economic impact of ... The nonstructural protein 1 (NS1) of the dengue virus interacts with another viral protein called NS4A-2K-4B to enable viral ... 2019) A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA ...
But it is clear that mosquitoes with Wolbachia growing in them produce far less dengue virus, and thus pose less of a risk of ... Gonad-chomping bacteria to be unleashed on dengue virus. A team of Indian researchers is importing larvae from Australia ... "Once in cells, Wolbachia seems to interfere with many (but not all) other pathogens, including dengue virus. Were just not ... It will be used to contain the spread of dengue, chikungunya, zika and other viruses spread by mosquitoes. ...
... team of researchers from the National University of Singapore has uncovered hidden vulnerabilities on the surface of the dengue ... sought to identify new approaches to tackle the dengue virus. The team monitored the changes that the dengue virus undergo in ... Dengue fever, caused by the dengue virus transmitted by the Aedes mosquito, is a serious global healthcare challenge which sees ... and when it is inside a patient suffering from dengue fever. When the dengue virus is transmitted to a healthy person, the ...
A memory B cell response to Zika virus in dengue-infected patients produced antibodies that were poorly neutralizing in vitro ... Dengue Vaccine Program Halted Over Safety Issues. By Shawna Williams , December 5, 2017 ... Dengue Infection Impairs Immune Defense Against Zika. By Catherine Offord , August 18, 2017 ... Infected with Wolbachia, the insects are expected to reduce the spread of dengue and Zika. But scientists say the approach may ...
Monoclonal Anti-Dengue virus type 4 E protein, clone E2 (produced in vitro ) Application: ... Dengue virus type 4 (ATCC® VR-1712™) Classification: Flaviviridae, Flavivirus / Product Format: frozen ... Monoclonal Anti-Dengue virus type 4 E protein, clone E2 (produced in vitro) ... On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes. J. Gen. Virol. 90: 799-809, 2009. PubMed: ...
... to serve as the first WHO reference reagent dengue virus antibody and to standardize the neutralization test for dengue viruses ... 2009)‎. Evaluation of commercially available anti-dengue virus immunoglobulin M tests. World Health Organization. https://apps. ... UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases & Pediatric Dengue Vaccine ... Hands-on Training/Workshop on the Laboratory Diagnosis of Measles Virus Infection, Melbourne, Australia, 24-27 May 2005 : ...
Dengue virus (DENV) infection causes a characteristic pathology in humans involving dysregulation of the vascular system. In ... Importantly, in 2 independent human dengue cohorts, tryptase levels correlated with the grade of DHF severity. This study ... some patients with dengue hemorrhagic fever (DHF), vascular pathology can become severe, resulting in extensive microvascular ...
Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells. *Townsley E ... Townsley, E., OConnor, G., Cosgrove, C., Woda, M., Co, M., Thomas, S. J., … Mathew, A. (2016). Interaction of a dengue virus ... During our investigation of CD8+ T cell responses to a conserved HLA-B57-restricted epitope derived from dengue virus (DENV) ... cells around the time of defervescence in subjects with severe dengue disease. Collectively, our findings indicate that subsets ...
High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of ... Dengue virus-elicited tryptase induces endothelial permeability and shock. Abhay P.S. Rathore,1 Chinmay Kumar Mantri,1 Siti A.B ... Dengue virus selectively induces human mast cell chemokine production. J Virol. 2002;76(16):8408-8419.. View this article via: ... Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Sci Transl ...
... scientists have identified dozens of proteins that help the dengue fever virus to grow and spread among mosquitoes and humans. ... Tags: dengue fever virus, duke university medical, duke university medical centre, dumc, fruit flies, fruit fly, garcia blanco ... Scientists identify protein that helps dengue virus grow. April 23rd, 2009 - 5:02 pm ICT by IANS Tweet. ... Almost half the people in the world are vulnerable to the dengue virus, says the World Health Organisation. Public health ...
They have located a human antibody that can neutralise and kill its virus within two hours. Significantly, they have also ... Scientists may have hit gold in their fight against dengue. ... Built-in dengue virus killer found in humans. June 24th, 2012 ... Hypothesis on mystery of dengue virus infection confirmed - Feb 12, 2010. *Worlds first dengue vaccine to be released soon - ... It has been proven to increase the survival in a mouse model infected with the dengue virus, according to a NUS statement. ...
... which neutralizes dengue virus infection in Aedes aegypti mosquitos. ... Dengue defends against Zika virus. "The antibody is able to hinder the replication of the virus and prevent its dissemination ... Dengue virus - transmitted by the mosquito Aedes aegypti - infects millions of people across Asian and Latin American countries ... Dengue virus infection can be severe and life threatening. New research has developed an improved approach to controlling this ...
  • This series, published in Journal of Biomedical Science , highlights recent advances in the research field of dengue virus infection. (biomedcentral.com)
  • Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). (biomedcentral.com)
  • Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. (biomedcentral.com)
  • Serologically defined primary dengue virus infection and/or subsequent homologous serotype infection is known to be associated with less severe disease as compared with secondary subsequent heterologous seroty. (biomedcentral.com)
  • This protein is secreted into the blood during dengue infection. (cdc.gov)
  • A positive NS1 test result is indicative of a dengue infection but does not provide serotype information. (cdc.gov)
  • A positive NS1 test result confirms dengue virus infection without providing serotype information. (cdc.gov)
  • Millions of cases of dengue infection occur worldwide each year. (yahoo.com)
  • 2. Prior infection with a dengue fever virus .Previous infection with a dengue fever virus increases your risk of having severe symptoms if you're infected again. (yahoo.com)
  • Sep 09, 2020 · Furthermore, some viral symptoms of dengue can mimic malaria infection . (yahoo.com)
  • Humans are known to carry the infection from one country to another or from one area to another during the stage when the virus circulates and reproduces in the blood system. (yahoo.com)
  • These results suggest that overcoming this restriction through transgenic mouse technology may help in the development of a long-sought immune-competent mouse model of dengue virus infection. (nih.gov)
  • Dengue virus may cause a mild to severe viral infection. (drugs.com)
  • Heart and skeletal muscle are targets of dengue virus infection," Pediatric Infectious Disease Journal , vol. 29, no. 3, pp. 238-242, 2010. (hindawi.com)
  • Host gene expression profiling of dengue virus infection in cell lines and patients," PLoS Neglected Tropical Diseases , vol. 1, no. 2, p. e86, 2007. (hindawi.com)
  • Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance," Proceedings of the National Academy of Sciences of the United States of America , vol. 108, no. 22, pp. 9190-9195, 2011. (hindawi.com)
  • S. J. Balsitis and E. Harris, "Animal models of dengue virus infection and disease: applications, insights and frontiers," in Frontiers in Dengue Virus Research , K. A. Hanley and S. C. Weaver, Eds. (hindawi.com)
  • What caused the widespread infection in Myanmar in 2001, a disease that resulted from one type of dengue virus, DENV-1? (nsf.gov)
  • Dengue infection is spread by mosquitoes and is caused by any of four closely related virus serotypes of the genus Flavivirus. (medindia.net)
  • Infection can cause diseases ranging from dengue fever, a flu-like illness, to the severest form -- dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), which can cause the blood vessels to leak, leading to life-threatening shock. (medindia.net)
  • The dengue virus antibody phenomenon, termed antibody-dependent enhancement of infection (ADE), was first hypothesized in the 1970s by Scott Halstead, a renowned scientist and one of the world's top experts on dengue virus infection. (medindia.net)
  • That was the first evidence we had that a person had to have a previous dengue infection to get the severe disease. (medindia.net)
  • Using the mouse model, Shresta's group has already made a key and surprising observation that a type of liver cells, called liver sinusoidal endothelial cells (LSCEs), but not the previously expected cells types (such as macrophages and dendritic cells) support ADE of dengue infection. (medindia.net)
  • She said: "This starts a cascade of unusual molecular events - the ADE process-which leads to the antibodies contributing to, rather than fighting, the dengue infection. (medindia.net)
  • Shresta's findings have appeared online in Cell Host and Microbe in her paper entitled, "Enhanced Infection of Liver Sinusoidal Endothelial Cells in a Mouse Model of Antibody-Induced Severe Dengue Disease. (medindia.net)
  • In 2016 alone, over 100,000 tested positive for dengue in the country, with hundreds dying from infection. (atimes.com)
  • A memory B cell response to Zika virus in dengue-infected patients produced antibodies that were poorly neutralizing in vitro and instead enhanced infection. (the-scientist.com)
  • Dengue virus (DENV) infection causes a characteristic pathology in humans involving dysregulation of the vascular system. (jci.org)
  • The process yielded 116 host factors that appeared to be important for successful dengue infection in fruit flies. (thaindian.com)
  • In testing several of these host factors in mosquitoes at Johns Hopkins University, researchers subsequently discovered that at least one - and possibly a second - was necessary for dengue infection to occur in the insects, said a DUMC release. (thaindian.com)
  • Dengue virus infection can be severe and life threatening. (biotechniques.com)
  • Currently, there are no targeted therapeutics against dengue infection. (biotechniques.com)
  • However, an international team of researchers, led by a group from the University of California San Diego (UCSD, CA, USA), may have identified a way to prevent dengue infection before it infects humans. (biotechniques.com)
  • Nearly half of the world's population is at risk of infection by the dengue virus, yet there is no specific treatment for the disease. (innovations-report.com)
  • This increases the risk of more severe secondary dengue infection. (innovations-report.com)
  • To lower the risk of dengue infection, travelers to tropical areas should take measures to avoid mosquitoes, the CDC said. (umn.edu)
  • The research team led by Jean Lim, PhD, Associate Professor of Microbiology and Co-Director of Microbiology Multidisciplinary Training in the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, transferred dengue virus-specific antibodies into mice prior to infection with Zika virus during pregnancy. (news-medical.net)
  • Our data demonstrate that antibodies generated from a previous dengue virus infection can enhance the severity of Zika virus infection during pregnancy,' said Dr. Lim. (news-medical.net)
  • Antibodies generated by a recent dengue virus infection can cause a falsely positive Zika IgM. (constantcontact.com)
  • Dengue infection can be confirmed by serum testing using dengue NAAT or anti-dengue virus IgM antibodies. (constantcontact.com)
  • Chikungunya virus infection is more likely to cause severe arthralgia and arthritis, while dengue virus infection is more likely to cause neutropenia, thrombocytopenia, hemorrhage, and shock. (constantcontact.com)
  • When evaluating a patient for dengue, providers should also consider testing for chikungunya infection using serum NAAT or IgM. (constantcontact.com)
  • The binding is tight and the specificity is high, enabling us to distinguish the presence of Dengue on the first day of infection. (newswise.com)
  • Single nucleotide polymorphisms in candidate genes and dengue severity in children: a case-control, functional and meta-analysis study," Infection, Genetics and Evolution , vol. 20, pp. 197-205, 2013. (hindawi.com)
  • Infection occurs when one is bitten by a female mosquito, usually Aedes aegypti, carrying the virus. (jamaica-gleaner.com)
  • The virus has four types, and while infection with one type usually gives lifelong immunity to that type, it only provides short-term immunity to the others. (jamaica-gleaner.com)
  • Severe dengue infection is currently the leading cause of childhood mortality in several Latin and Asian countries, with a growing number of locally acquired infections in Florida, Texas, and Hawaii. (ucsd.edu)
  • Thus, it is only currently approved for use in countries with high rates of infection, and effective antiviral treatments are still needed to treat severe dengue infection. (ucsd.edu)
  • Manifestations of Zika virus (ZIKV) infection differ drastically. (eurasiareview.com)
  • It reports that mice rendered immune to dengue show "cross-protection" from subsequent Zika infection and then identifies specific types of immune T-cells capable of defending against both viruses. (eurasiareview.com)
  • Specifically, Shresta's team created the first "sequential" mouse model mimicking dengue-then-Zika infection. (eurasiareview.com)
  • Those mice became sick, recovered from infection, and hence acquired immunity to dengue, presumably because viral infection had mobilized their immune B-cells, T-cells or both. (eurasiareview.com)
  • Earlier, strain 2 of dengue - DENV 2 - was the one commonly found in India, but now not only are different strains causing infection in the country but also causing infection simultaneously during the same season. (hindustantimes.com)
  • These antibodies are highly cross-reactive among the dengue virus serotypes and, even at high concentrations, do not neutralize infection but potently promote ADE. (sciencemag.org)
  • Dengue virus (DENV) is a mosquito-borne virus infection found in tropical and subtropical areas of the world, with an estimated 50 to 100 million infections per year ( 1 ). (sciencemag.org)
  • While researchers have concluded that Zika infection can cause microcephaly and other birth defects such as eye damage in newborns, there are still many unanswered questions about the virus. (theconversation.com)
  • My colleagues and I wanted to find out whether having immunity to dengue from an earlier infection could make a Zika infection worse. (theconversation.com)
  • Antibodies raised in response to NS1 in viral infection can cross react with cell surface antigens on epithelial cells and platelets and this has been implicated in the development of Dengue Hemorrhagic fever. (abcam.com)
  • This finding tells us that the protein-digesting activity of the mosquito gut can influence the success of dengue virus in establishing infection in the mosquito,' Dimopoulos says. (infectioncontroltoday.com)
  • Certain strains of dengue virus, the agent of dengue fever, can progress into a severe infection called dengue hemorrhagic fever, which kills about 5 percent of the people who develop it, Hanley explains. (infectioncontroltoday.com)
  • Murray and colleagues first checked the clinical samples for immunoglobulin M (IgM) antibodies, the antibodies that represent acute dengue infection, and found that 47 of the 3,768 samples were positive for IgM antibodies specific to the dengue virus. (chron.com)
  • A person experiencing a second DENV infection with a different serotype faces a greater risk of developing severe dengue hemorrhagic fever and shock syndrome. (nature.com)
  • The development of a compelling murine model of dengue virus (DENV) infection has been challenging, because DENV clinical isolates do not readily replicate or cause pathology in immunocompetent mice. (frontiersin.org)
  • The development of an adequate mouse model for dengue infection has been challenging, mainly because DENV clinical isolates fail to replicate or cause pathology in wildtype (WT) mice. (frontiersin.org)
  • Previous infection with dengue virus may protect children from symptomatic Zika, according to a study published January 22 in the open-access journal PLOS Medicine. (eurasiareview.com)
  • The authors found that prior and recent dengue virus infection was associated with protection from symptomatic Zika virus infection in the total cohort population and among those infected with the Zika virus. (eurasiareview.com)
  • By contrast, prior or recent dengue virus infection did not affect the rate of total Zika virus infection. (eurasiareview.com)
  • According to the authors, more research is needed to address the possible immunological mechanisms of cross-protection between Zika and dengue viruses and whether dengue virus immunity also modulates severe outcomes of Zika virus infection such as neurological or congenital syndromes. (eurasiareview.com)
  • Dengue virus (DENV) infection is a worldwide public health problem, which can cause severe dengue hemorrhagic fever (DHF) and life-threatening dengue shock syndrome (DSS). (springer.com)
  • There are four serotypes, or variations, of the dengue virus which has made it difficult to produce a vaccine to prevent an infection from all four types. (sciencephoto.com)
  • Infection with one strain of the dengue virus gives people protection against the other three strains for about two years, a new biostatistics study has found. (umass.edu)
  • Dengue is a viral infection causing a serious flu-like illness and sometimes causing a potentially lethal complication called severe dengue. (surrey.ac.uk)
  • T Cell Immunopathogenesis of Dengue Virus Infection. (who.int)
  • Schmidt-Chanasit J , Haditsch M , Schöneberg I , Günther S , Stark K , Frank C . Dengue virus infection in a traveller returning from Croatia to Germany. (eurosurveillance.org)
  • In vitro studies of bioterror and pandemic threats have verified Hemopurifier® capture of ebola hemorrhagic virus, dengue hemorrhagic virus, lassa hemorrhagic virus, H5N1 avian influenza (bird flu), the reconstructed 1918 influenza virus (r1918), 2009 H1N1 influenza virus (swine flu), West Nile virus, and monkeypox, which serves as a model for human smallpox infection. (bio-medicine.org)
  • It was recently reported that as many as 390 million dengue infections occur worldwide each year, thus making this infection potentially even more prevalent than malaria ( 3 ). (frontiersin.org)
  • Besides prior infection with one serotype, other factors influencing the disease outcome are the strain of infecting virus, age and gender, nutritional status, and the genetic background of the patient ( 11 - 16 ). (frontiersin.org)
  • The activation of autophagy and ER stress during infection enhances virus reproduction. (wikipedia.org)
  • Dengue is the most prevalent arthropod-borne viral illness in humans, and half of the world's population is at risk for infection. (biomedsearch.com)
  • Chrysin-7-yl phosphate may serve as potential protective agents in the treatment of patients with chronic dengue virus infection. (greenmedinfo.com)
  • Our finding has the potential to halt the spread of the dengue virus which is vital as there is currently no vaccine and the geographical areas of infection are growing. (healthcanal.com)
  • There have been around 2,400 cases of dengue infection in Northern Australia in recent years. (healthcanal.com)
  • The team also aims to conduct trials in areas with endemic dengue infection such as Thailand, Vietnam, Brazil and Indonesia to directly determine the effectiveness of the method in reducing dengue disease in human populations. (healthcanal.com)
  • In this study, researchers used electron microscopes to watch the early stages of the infection process, labelling the viruses while they entered cells. (elsevier.com)
  • Dengue virus (DV) infection causes a spectrum of clinical diseases ranging from dengue fever to a life-threatening dengue hemorrhagic fever. (sigmaaldrich.com)
  • Dengue virus generally causes mild disease, however, more severe forms of the dengue virus infection, dengue haemorrhagic fever (DHF) and dengue haemorrhagic fever with shock syndrome (DSS) can also occur, resulting in multiple organ failure and even death, especially in children. (medsci.org)
  • Natural News ) Women who contracted dengue early in their lives do not need to worry about contracting more severe forms of Zika infection and subsequently passing its effects on to their unborn babies, according to a new study. (naturalnews.com)
  • The study, in which virologists say a person's previous dengue infection can help protect against Zika-associated damage , was published in the Journal of Emerging Infectious Diseases . (naturalnews.com)
  • We can now say that people who have had early infections with dengue do not need to worry much about contracting more severe forms of Zika infection due to this," Jan Felix Drexler, a virologist and professor at Charité - Universitätsmedizin Berlin , said. (naturalnews.com)
  • According to the study, dengue viruses, which are widespread in Latin America and are transmitted by mosquitoes from the Aedes species, as well as the antibodies that humans produce against them, were suspected to be possible cofactors that contribute to the fetal damage caused in later Zika infection - they were wrong. (naturalnews.com)
  • According to Drexler, this suggested that rather than enhance the development of Zika-related congenital malformations, dengue virus infection may in fact, offer protection against it. (naturalnews.com)
  • Surprisingly, our study has shown that a previous dengue infection can protect against Zika-associated damage," Drexler said. (naturalnews.com)
  • In 2015, Brazil reported a large outbreak of an illness characterized by rashes, which was then identified as a Zika virus infection. (naturalnews.com)
  • An association between Zika virus infection and microcephaly was discovered soon after. (naturalnews.com)
  • The complete 3'UTR of DENV-1 was sequenced from 13 patients suffering from the severe form of dengue virus infection (dengue hemorrhagic fever). (unboundmedicine.com)
  • We now know for sure that Zika virus infection during pregnancy can affect the unborn foetus in such a way that the child develops microcephaly and other severe symptoms," explains Prof Felix Drexler, a virologist at Charité who has been developing diagnostic tests for Zika and other viruses at the DZIF. (medicalxpress.com)
  • Initially, the scientists suspected that the antibodies humans produce against the dengue virus contribute to the foetal damage caused in later Zika infection . (medicalxpress.com)
  • We can now say that people who have had early infections with dengue do not need to worry much about contracting more severe forms of Zika infection due to this," summarises Drexler. (medicalxpress.com)
  • Consequently, it could not be confirmed that the dengue virus acts as a cofactor for congenital Zika infection. (medicalxpress.com)
  • The dengue virus is also transmitted by mosquitoes of the Aedes species and has similar symptoms to Zika infection. (medicalxpress.com)
  • Celia Pedroso et al, Cross-Protection of Dengue Virus Infection against Congenital Zika Syndrome, Northeastern Brazil, Emerging Infectious Diseases (2019). (medicalxpress.com)
  • Mice models of Zika infection were treated with Dengue antibodies. (bioconferencelive.com)
  • Mice given Dengue antibodies were less likely to die and lose weight, and researchers found significantly lower levels of virus in their brain and testes, two areas known to be packed with Zika virus during infection. (bioconferencelive.com)
  • In addition to treating mice already infected with Zika virus, antibody treatment was also able to protect unborn mice pups in pregnant mice with the infection. (bioconferencelive.com)
  • This paper shows for the first time that antibodies we had previously found to be effective against Dengue potently protect against Zika virus in mice and can treat the early stages of infection," said Gavin Screaton, senior author of the study. (bioconferencelive.com)
  • In May 2019, Dengvaxia was approved in the United States as the first vaccine approved for the prevention of dengue disease caused by all dengue virus serotypes (1, 2, 3 and 4) in people ages nine through 16 who have laboratory-confirmed previous dengue infection and who live in endemic areas. (wikipedia.org)
  • In 2017, the manufacturer recommended that the vaccine only be used in people who have previously had a dengue infection, as outcomes may be worsened in those who have not been previously infected. (wikipedia.org)
  • This development means that in the foreseeable future there may be viable genetic approaches to controlling dengue virus in the field, which could limit human suffering and mortality," said Akbari, whose lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. (newswise.com)
  • Mosquitoes have been given the bad rap of being the deadliest killers on the planet because they are the messengers that transmit diseases like malaria, dengue, chikungunya, Zika and yellow fever that collectively put 6.5 billion people at risk globally," said Suresh Subramani, professor emeritus of molecular biology at UC San Diego and global director of the Tata Institute for Genetics and Society (TIGS). (newswise.com)
  • Though West Nile belongs to the same genus that contains the Zika, dengue and yellow fever viruses, most people who are infected develop no symptoms. (yahoo.com)
  • It will be used to contain the spread of dengue, chikungunya, zika and other viruses spread by mosquitoes. (atimes.com)
  • Asian tiger mosquito Aedes albopictus, one of the species that can carry the Zika virus, begins its blood meal. (livescience.com)
  • Infections with Zika virus, which is carried by mosquitos, are on the rise across the Americas, raising concerns among health officials. (livescience.com)
  • On Thursday (Dec. 10), officials in Panama announced the country's first case of locally acquired Zika virus - meaning that a person caught the disease from a mosquito in that country, rather than while traveling elsewhere - raising the number of countries in the Americas with reported cases of Zika infections to 10. (livescience.com)
  • The Zika virus is a relative of the viruses that cause dengue fever, yellow fever and West Nile infections. (livescience.com)
  • Currently, there is no vaccine for Zika, although those infected by the virus can be treated to relieve its symptoms. (livescience.com)
  • Infections are transmitted to people through bites from infected Aedes mosquitos, a genus of mosquitos that includes several species that also carry other viruses that are closely related to Zika. (livescience.com)
  • Initially detected in humans in 1954 in Nigeria, Zika virus was largely confined to Africa and Asia until the first cases emerged in the South Pacific in 2007, according to a 2009 study published in the journal Emerging Infectious Diseases . (livescience.com)
  • Traces of the virus were found in affected newborns' amniotic fluid, confirming health officials' fears that Zika virus was linked to the birth defect. (livescience.com)
  • Authorities in French Polynesia have also reported a recent uptick in brain defects and lesions in fetuses and newborns that correspond to Zika virus outbreaks. (livescience.com)
  • Although none of the mothers demonstrated symptoms of Zika virus, test results showed that four of them might have been carrying it, according to the PAHO. (livescience.com)
  • This novel discovery means that scientists can now develop strategies to target these weak spots for treatment of dengue, and possibly other closely related diseases like Zika, influenza and chikungunya. (eurekalert.org)
  • This is a very exciting discovery as it offers numerous possibilities of designing therapies and vaccines to target these exposed surfaces to treat dengue as well as other related viruses such as Zika and chikungunya. (eurekalert.org)
  • A single receptor on natural killer cells recognizes an amino acid sequence conserved across Zika, dengue, and related pathogens. (the-scientist.com)
  • The US government has approved the deployment of the lab-raised insects to eliminate the Zika- and dengue-transmitting Asian tiger mosquito. (the-scientist.com)
  • The mosquitoes that carry Zika may be able to transmit two other viruses at the same time. (the-scientist.com)
  • Infected with Wolbachia, the insects are expected to reduce the spread of dengue and Zika. (the-scientist.com)
  • Women who have previously been infected with dengue virus may be at risk for increased damage to their fetuses and placentas if they should later become infected with the Zika virus, researchers from the Department of Microbiology at the Icahn School of Medicine at Mount Sinai report. (news-medical.net)
  • This study is the first to report a possible mechanism for the enhancement of Zika virus progression during pregnancy in an animal model. (news-medical.net)
  • Results of the study, 'Dengue virus immunity increases Zika virus-induced damage during pregnancy,' were published in the February issue of Immunity , a journal published by Cell Press. (news-medical.net)
  • Zika virus outbreaks were first found to be associated with birth defects including microcephaly, in which the baby is born with an abnormally small head and brain, in 2015 in Brazil, where dengue virus, a virus closely related to Zika virus, is endemic. (news-medical.net)
  • Zika-infected human placental tissues also showed increased replication in the presence of dengue antibodies. (news-medical.net)
  • Our research may explain the high rate of microcephaly and birth defects observed in the recent Zika virus outbreak in South America. (news-medical.net)
  • Due to the changing global epidemiology of Zika virus disease, the US Centers for Disease Control and Prevention (CDC) updated their serologic testing recommendations in November 2019 to no longer endorse routine serological IgM testing for Zika virus. (constantcontact.com)
  • Cases of locally transmitted Zika in the continental United States or territories have not been reported since May 2018, and limited-to-no Zika virus transmission is currently being reported globally. (constantcontact.com)
  • In 2019, California reported only one confirmed, symptomatic case of Zika virus in an international traveler, and none were reported in Orange County. (constantcontact.com)
  • The CDC no longer recommends routine serological IgM testing for Zika virus. (constantcontact.com)
  • Moreover, there is significant cross-reactivity between dengue IgM and Zika IgM antibodies in serologic tests. (constantcontact.com)
  • Dengue IgM antibodies are detectable beginning 3-5 days after illness onset but positive results can be difficult to interpret due to cross-reaction with IgM antibodies against Zika virus and other closely related flaviviruses. (constantcontact.com)
  • The spherical surface of Dengue, like the closely related Zika virus, are studded with multiple latch points to catch a cell surface. (newswise.com)
  • Like chikungunya and Zika, dengue fever is a mosquito-borne tropical disease caused by a virus. (jamaica-gleaner.com)
  • Unlike chikungunya and Zika, however, dengue is endemic to Jamaica. (jamaica-gleaner.com)
  • By stretching the amount of time proteins can be simulated in their natural state of wiggling and gyrating, a team of researchers at Colorado State University has identified a critical protein structure that could serve as a molecular Achilles heel able to inhibit the replication of dengue virus and potentially other flaviviruses such as West Nile and Zika virus. (ucsd.edu)
  • This is a transmission electron micrograph (TEM) of Zika virus, which is a member of the family Flaviviridae. (eurasiareview.com)
  • But overall, mice that had previously acquired dengue immunity showed protection against Zika, as evidenced by a reduced burden of ZIKV in blood and tissues, such as brain, liver or testis, compared to control mice not "pre-inoculated" against dengue. (eurasiareview.com)
  • These experiments suggest that the reason that some people infected with Zika do not come down with disease is due to prior exposure to dengue," says Shresta. (eurasiareview.com)
  • This may explain why Zika is not passed to the unborn child of every pregnant woman in dengue-endemic countries exposed to virus. (eurasiareview.com)
  • Glutathionylation of dengue and Zika NS5 proteins affects guanylyltransferase and RNA dependent RNA polymerase activities. (abcam.com)
  • Revellers at a carnival in Sao Paulo wear mosquito masks in a reference to the Aedes aegypti mosquito, which can spread dengue and Zika on February 4, 2016. (theconversation.com)
  • I study flaviviruses, which include Zika and dengue, at Florida Gulf Coast University. (theconversation.com)
  • Like other flavivirus researchers, I am turning to dengue to better understand Zika. (theconversation.com)
  • Dengue, a close relative of Zika, is regularly found in places like Brazil, and is spread by the same mosquitoes, Aedes aegypti . (theconversation.com)
  • Aedes aegypti mosquitoes can transmit both Zika and dengue viruses. (theconversation.com)
  • Map showing countries affected by the Zika virus. (theconversation.com)
  • By early 2015 the virus had spread to the Americas, and the first confirmed case of locally acquired Zika in the region was confirmed in May 2015 by Brazil's National Reference Laboratory. (theconversation.com)
  • The Pan American Health Organization reports that Zika virus transmission had occurred in over 48 countries or territories in the Americas , with 177,614 confirmed cases of locally acquired Zika in the region, over half a million suspected cases, and 2,525 confirmed congenital syndrome associated cases with Zika infections as of Dec. 29. (theconversation.com)
  • Since Zika had not been reported in the region prior to 2015, people, including women of child-bearing age, had never been exposed to the virus. (theconversation.com)
  • And the areas of the Pacific and the Americas that experienced explosive Zika outbreaks have two things in common: they had not been exposed to Zika before and dengue is endemic. (theconversation.com)
  • While Hanley's team primarily works with dengue virus, the systems developed through these studies can be generalized to apply to arthropod-borne viruses on a broader scale, making the research relevant to West Nile virus, as well as chikungunya and Zika viruses, which are both currently moving up from South America. (infectioncontroltoday.com)
  • He was also the editor for book on Zika virus disease. (researchandmarkets.com)
  • Zika virus emerged in northeast Brazil in 2015 and spread rapidly across the Americas, affecting populations that have been largely exposed to dengue virus. (eurasiareview.com)
  • Because Zika and dengue viruses are closely related, it is possible that pre-existing dengue virus immunity may also impact susceptibility to Zika. (eurasiareview.com)
  • But the impact of previous exposure to the dengue virus on outcomes in those infected with the Zika virus remains unclear. (eurasiareview.com)
  • To study this potential impact, Harris and colleagues analyzed the large 2016 Zika epidemic in Managua, Nicaragua, focusing on a pediatric cohort with well-characterized dengue virus immune histories. (eurasiareview.com)
  • These findings support the idea that prior dengue virus immunity might cross-protect against symptomatic Zika. (eurasiareview.com)
  • A funny-sounding bacteria that you've never heard of-Wolbachia-will likely be an important weapon in the fight against Zika, dengue and other viruses plaguing the tropics. (biospace.com)
  • Additionally, coinfection with and lack of rapid tests for zika virus and chikungunya complicate matters in real-world infections. (wikipedia.org)
  • Zika virus is a member of the Flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. (archives-ouvertes.fr)
  • Zika virus is related to dengue virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue virus also potently neutralize Zika virus. (archives-ouvertes.fr)
  • The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during virus maturation. (archives-ouvertes.fr)
  • Where Will the World's Next Zika, West Nile or Dengue Virus Come From? (ucdavis.edu)
  • After collecting data and comparing it with every known mammal and bird species on Earth, scientists from the University of California, Davis, have identified wildlife species that are the most likely to host flaviviruses such as Zika, West Nile, dengue and yellow fever. (ucdavis.edu)
  • Dengue virus belongs to the Flaviviridae family which also includes viruses such as the Zika, West Nile and yellow fever virus. (medsci.org)
  • When Zika virus was suspected of causing birth defects such as microcephaly, Fogarty-supported scientists who had been working on Chagas disease and dengue shifted gears. (nih.gov)
  • As more and more babies in Brazil were born with microcephaly in 2015, Fogarty-supported scientists rapidly changed gears on work they'd been doing for years on Chagas disease and dengue, and shifted their focus to the Zika virus, which was suspected of causing the spate of birth defects. (nih.gov)
  • Meanwhile, in Mexico, two Fogarty-supported Ph.D. candidates who were researching different aspects of preventing and controlling dengue - transmitted by the same Aedes aegypti mosquito as Zika - refocused their work on Zika. (nih.gov)
  • In Chagas, we think this is primarily due to the activation of the immune system, but in Zika we're early in the research process and we don't know how much of the problem is due to the direct effect of the Zika virus in the brain and how much is due to activation of the immune system. (nih.gov)
  • One study, published in Cell, found that exposing adult mice to the Zika virus can cause their neural stem cells to become infected, leading to cell death and reduced proliferation. (nih.gov)
  • Typically transmitted through the bite of Aedes mosquitoes (like its close cousins West Nile virus and Zika virus), symptoms range from mild flu-like symptoms to, in rare cases, severe hemorrhagic fever, which can be fatal. (blood.ca)
  • As a first step to investigating the interactions between dengue and Zika viruses, the genomes of all known dengue viruses in Brazil were compared to each other. (medicalxpress.com)
  • The study showed that an existing immunity against dengue virus significantly reduces the risk of Zika-associated microcephaly in newly borns. (medicalxpress.com)
  • Felix Drexler and his research group have already developed several novel Zika virus tests. (medicalxpress.com)
  • Zika viruses are usually transmitted by mosquitoes, particularly by the Aedes species, but they can also be transmitted sexually. (medicalxpress.com)
  • Killing two birds with one stone may be possible for Dengue virus and Zika virus, two pathogens spread by the same mosquito and which come from the same viral family. (bioconferencelive.com)
  • The new study, a collaboration between Imperial College London and Washington University in St. Louis, displayed the protective effect of human antibodies from Dengue virus patients in mice models of Zika virus. (bioconferencelive.com)
  • The same group of scientists first discovered in a past study that antibodies from the blood of people infected with Dengue virus were capable of targeting both Dengue and Zika. (bioconferencelive.com)
  • During ADE, antibodies successfully recognize and flag Zika virus, but immune cells fail to act on those flags and kill the virus. (bioconferencelive.com)
  • Researchers hope to make possible a new vaccine based on the Dengue antibodies that are capable of targeting both Dengue virus and Zika virus. (bioconferencelive.com)
  • This group of antibodies is unique in being able to target Dengue and Zika," Screaton explained. (bioconferencelive.com)
  • A total of 28 cases of the Zika virus have been reported in Kerala. (ndtv.com)
  • The Health Department along with local self-government has formulated an action plan for control and prevention of dengue fever as a few cases have been reported in Kerala besides Zika virus, said Health Minister Veena George on Thursday. (ndtv.com)
  • The meeting of the two departments was convened in the wake of reports of dengue fever in addition to the Zika virus. (ndtv.com)
  • Zika virus tests will be increased. (ndtv.com)
  • There are four serotypes of dengue viruses (DENV), each of which is capable of causing self-limited dengue fever (DF) or even life-thre. (biomedcentral.com)
  • Dr. Shresta said the fact that dengue viruses exist as four different serotypes that circulate simultaneously underlies the development of the subneutralizing antibodies. (medindia.net)
  • On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes. (atcc.org)
  • This newly discovered antibody specifically treats DENV1, one of the four dengue serotypes, which accounts for up to 50 percent of the dengue cases in Southeast Asian countries. (thaindian.com)
  • The combined effort from researchers at UCSD and Vanderbilt University Medical Center (TN, USA) resulted in the identification of a 'broad-spectrum' human antibody, which neutralizes all four serotypes of the virus. (biotechniques.com)
  • That's because dengue is not one virus but four different viruses, or serotypes, each of which must be neutralized by the vaccine. (innovations-report.com)
  • Protecting people from only one or some of the four viruses could cause them to develop the more severe form of dengue if they later become infected with one of the other serotypes, in a process known as antibody-dependent enhancement, Sasisekharan says. (innovations-report.com)
  • Research teams have previously attempted to engineer an antibody that targets the loop region of the virus protein, as this is known to be able to attack all four serotypes if targeted in the right way. (innovations-report.com)
  • When they tested their mutated antibody on samples of the four dengue serotypes in the laboratory, they found it had a 450-fold increase in binding to dengue 4, a 20-fold increase in binding for dengue 2, and lesser improvements in binding for dengue 1 and 3, Sasisekharan says. (innovations-report.com)
  • Caused by one of four closely related virus serotypes of the genus Flavivirus, family Flaviviridae, each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. (abcam.com)
  • Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common. (sciencemag.org)
  • The four-dengue virus (DENV) serotypes infect several hundred million people annually. (nature.com)
  • The four serotypes of DENV are the most prevalent mosquito-borne viruses that affect humans ( 4 ). (frontiersin.org)
  • Kinney RM, Huang CY, Rose BC, Kroeker AD, Dreher TW, Iversen PL, Stein DA (2005) Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers. (springer.com)
  • Five serotypes of the virus have been found, all of which can cause the full spectrum of disease. (wikipedia.org)
  • Four dengue virus serotypes (DENV-1 to DENV-4) are transmitted to humans. (thefreelibrary.com)
  • Among the mAbs, 10 out of 12 showed cross-reactivity to four DV serotypes as well as Japanese encephalitis virus (JEV) in different cross-reactivity patterns. (sigmaaldrich.com)
  • Four distinct serotypes of the dengue virus (dengue-1, dengue-2, dengue-3, and dengue-4) exist, with numerous virus strains found worldwide. (asm.org)
  • Since 2010, India has been witnessing a marked increase in the number of dengue virus serotype 1 (DENV-1) infections, apart from those of serotypes 2 (DENV-2) and 3 (DENV-3). (go.jp)
  • The currently circulating genotypes of DENV-1 identified from the study area belong to genotypes V and I. Multicentric laboratory-based studies analyzing the envelope gene of all dengue serotypes are required from endemic countries like India. (go.jp)
  • The mutations which fall within the conserved regions of all four dengue serotypes are discussed. (medsci.org)
  • The results indicated that there were much lower levels of dengue virus pathogens and neutralized serotypes in mothers of children born with CZS. (naturalnews.com)
  • In addition, the scientists conducted extensive serological tests in Salvador, Brazil: Samples from a case-control study were tested for antibodies against four different dengue serotypes. (medicalxpress.com)
  • Development of dengue vaccines began in the 1920s, but was hindered by the need to create immunity against all four dengue serotypes. (wikipedia.org)
  • CYD-TDV, sold under the brand name Dengvaxia and made by Sanofi Pasteur, is a live attenuated tetravalent chimeric vaccine made using recombinant DNA technology by replacing the PrM (pre-membrane) and E (envelope) structural genes of the yellow fever attenuated 17D strain vaccine with those from the four dengue serotypes. (wikipedia.org)
  • In a paper published this week in the journal PLoS Pathogens, scientists funded by the National Science Foundation (NSF) report a significant link between one such defective virus and the high rate of transmission of DENV-1 in Myanmar in 2001. (nsf.gov)
  • and Edward Holmes, a biologist at the University of Sydney--found that the presence of a defective DENV-1 virus may have led to a spike in dengue fever cases in Myanmar during 2001-2002. (nsf.gov)
  • In the study, Ke designed a mathematical model to learn how the defective DENV-1 virus interacted with the normal virus. (nsf.gov)
  • Dengue virus (DENV)--a mosquito transmitted pathogen--is the causative agent of Dengue fever, the most important arboviral disease of humans, which affects an estimated 50-100 million people annually. (nih.gov)
  • An improved understanding of the molecular mechanisms underlying the different steps of the DENV replication cycle, for example, genome replication and virus maturation, could help to develop such substances. (nih.gov)
  • Dengue virus (DENV) can inhibit both type I IFN production and signaling in susceptible human cells, including dendritic cells (DCs). (mdpi.com)
  • In this review, we will evaluate the contribution of innate immunity evasion by DENV to the pathogenesis and host tropism of this virus. (mdpi.com)
  • However, increasing samples were negative for dengue-specific IgM, we ampli- travel has resulted in imported dengue cases in other prov- fied DENV sequences from them, as described in the next inces, including northern temperate regions ( 6 , 7 ), and some section. (cdc.gov)
  • Garcia-Blanco and colleagues in Duke's RNAi facility were able to knock down gene function in fruit fly cells infected with a strain of the dengue virus known as DENV-2. (thaindian.com)
  • The partial cross-reactivity may cause a degree of opsonization that promotes virus uptake into Fc-bearing cells such as monocytes and macrophages-a major site of DENV replication in vivo-leading to increased virus replication. (sciencemag.org)
  • In children with no immunity to DENVs at baseline, Dengvaxia was poorly efficacious and the vaccine increased the risk of severe dengue disease upon exposure to wild type DENV infections. (nature.com)
  • Dengue virus (DENV) is the etiologic agent of the self-limited febrile illness dengue fever (DF), as well as the potentially lethal severe dengue disease (previously referred to as dengue hemorrhagic fever and dengue shock syndrome, DHF/DSS). (frontiersin.org)
  • Due to the absence of signs of disease, it is difficult to study DENV-induced pathology in NHP, but NHP can be used for testing immunogenicity, safety, and/or protective efficacy of dengue vaccine candidates by measuring induction of anti-DENV antibodies and magnitude and duration of viremia after vaccination or challenge ( 14 - 23 ). (frontiersin.org)
  • Dengue virus (DENV) is a member of the Flaviviridae family, transmitted to human via mosquito. (sigmaaldrich.com)
  • The results showed that vivo-MOs could bind to a DENV RNA sequence and markedly reduce DENV-RNA, protein, and virus production in infected Vero and A549 cells. (springer.com)
  • Symptomatic dengue virus (DENV) infections range from mild fever to severe haemorrhagic disease and death. (nih.gov)
  • A better understanding of the UPR mediated antiviral and proviral effects will shed light on dengue disease pathogenesis and may help development of anti-DENV therapeutics. (nih.gov)
  • In vitro propagation of Dengue virus (DENV) has been conventionally studied under atmospheric oxygen levels despite that in vivo, the tissue microenvironment is hypoxic. (mdpi.com)
  • In DENV-infected cells, hypoxia had no effect on virus entry and RNA translation, but enhanced RNA replication. (mdpi.com)
  • Finally, reactive oxygen species were shown to contribute, at least in part through HIF, both to the hypoxia-mediated increase of DENV replication and to virus-induced hypoxic reprogramming. (mdpi.com)
  • The dengue virus (DENV) NS3 protein is essential for viral polyprotein processing and RNA replication. (rcsb.org)
  • Dengue virus (DENV) is endemic in south-east Asia and Central to South America. (eurosurveillance.org)
  • Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. (frontiersin.org)
  • A unique challenge in vaccine development against DENV is the high degree of sequence variation, characteristically associated with RNA viruses. (frontiersin.org)
  • Dengue virus (DENV) is the causative agent of dengue fever, the most prevalent mosquito-borne viral illness in humans and is primarily transmitted by the mosquitoes Aedes aegypti and Aedes albopictus ( 1 ). (frontiersin.org)
  • Dengue virus (DENV) is the cause of dengue fever. (wikipedia.org)
  • Dengue fever is a tropical disease and caused by dengue virus (DENV), which is transmitted by mosquitoes and infects about 400 million people annually. (greenmedinfo.com)
  • Dengue virus (DENV, shown in Fig.1) can cause dengue fever. (sophia.org)
  • Of note have been the dengue epidemics that have succeeded the introduction of DENV-1 into Cuba and its transmission during 1977-1978 to nearly 45% of the population. (thefreelibrary.com)
  • In 1997, an Asian DENV-2 virus was again introduced into the city of Santiago de Cuba and DF and DHF were again observed, this time in persons [greater than or equal to] 20 years of age (2). (thefreelibrary.com)
  • A recent DENV-1 epidemic has provided an opportunity to relate the occurrence of DHF to a history of exposure of the population to another dengue serotype. (thefreelibrary.com)
  • Four years after a large DENV-2 epidemic that began in 1996 and affected all of French Polynesia, ending in 1997, in January 2001 DENV-1 virus was identified on Bora Bora Island. (thefreelibrary.com)
  • The characteristics of DENV-1 viruses, isolated during the 2001-2002 outbreak in Indonesia were studied. (unboundmedicine.com)
  • Dengue fever is caused by any one of four types of dengue viruses spread by mosquitoes that thrive in and near human lodgings. (yahoo.com)
  • An international team of scientists has synthetically engineered mosquitoes that halt the transmission of the dengue virus. (newswise.com)
  • The development marks the first engineered approach in mosquitoes that targets the four known types of dengue, improving upon previous designs that addressed single strains. (newswise.com)
  • A team led by Omar Akbari's lab at UC San Diego has engineered the first mosquitoes that repel the four known times of dengue virus. (newswise.com)
  • Led by biologists at the University of California San Diego, the research team describes details of the achievement in Aedes aegypti mosquitoes, the insects that spread dengue in humans, on January 16 in the journal PLOS Pathogens . (newswise.com)
  • They then designed the antibody "cargo" to be synthetically expressed in female A. aegypti mosquitoes, which spread the dengue virus. (newswise.com)
  • This paper shows that it is possible to immunize mosquitoes and prevent their ability to transmit dengue virus, and potentially other mosquito-borne pathogens. (newswise.com)
  • However, a person infected and suffering from dengue fever can infect other mosquitoes. (yahoo.com)
  • But though the disease cannot move from person to person, mosquitoes are able to pick up dengue from infected patients and, in turn, spread the disease among a local populace. (medicinenet.com)
  • Florida has the mosquitoes that transmit dengue and the climate to sustain these mosquitoes all year around," cautioned study lead author Jorge Munoz-Jordan. (medicinenet.com)
  • The upshot: In some cases the dengue fever "smoking gun" was the local Florida mosquito population, rather than mosquitoes from other regions. (medicinenet.com)
  • Dengue is a disease transmitted by mosquitoes and caused by four types of the dengue virus. (nsf.gov)
  • Even after several rounds of insecticide sprays a year, not to mention use of drug-treated nets and other measures, mosquitoes continue to spread the dreaded dengue across India. (atimes.com)
  • However, LLINs are not used for control of dengue, since Aedes mosquitoes have vast breeding sites in and around human habitations where nets may not be effective," says the former Regional Adviser for the World Health Organisation (SEARO) and present Vice-Chancellor of Central University of Tamil Nadu, in Thiruvarur. (atimes.com)
  • Wolbachia, a natural bacterium first identified in 1924 in Culex mosquitoes, could be used as a novel form of biological control by getting it into the Aedes aegypti mosquitoes that spread dengue, Prof. Dash tells Asia Times. (atimes.com)
  • Washington, April 23 (IANS) By silencing genes one by one, scientists have identified dozens of proteins that help the dengue fever virus to grow and spread among mosquitoes and humans. (thaindian.com)
  • Now a portable tool to detect dengue mosquitoes! (thaindian.com)
  • Can GM mosquitoes wipe out dengue? (thaindian.com)
  • Suresh Subramani, global director of the Tata Institute for Genetics and Society (Bengaluru, India) and professor at UCSD concluded: "this paper shows that it is possible to immunize mosquitoes and prevent their ability to transmit dengue virus and potentially other mosquito-borne pathogens. (biotechniques.com)
  • Broad dengue neutralization in mosquitoes expressing an engineered antibody. (biotechniques.com)
  • If mosquitoes don't become infected with dengue, they cannot transmit the virus to people," Lloyd explains. (innovations-report.com)
  • Travelers who come home with dengue infections could trigger localized outbreaks if they are bitten by Aedes species of mosquitoes while carrying the virus, the CDC said. (umn.edu)
  • Preventive steps not only help the traveler, but also reduce the chance of bringing the virus into US regions where mosquitoes could spread it. (umn.edu)
  • Dengue virus is transmitted by Aedes aegypti and other mosquitoes, with approximately 50 million serious infections worldwide each year, and 20,000 deaths. (ucsd.edu)
  • Historically, dengue has predominantly been reported from the southern state as the population of the vector - aedes aegypti mosquitoes - was high in these states and once the disease is in circulation, more mosquitoes mean more people at risk of contracting the disease," said Dr Sunil. (hindustantimes.com)
  • A species of fungus that lives in the gut of some Aedes aegypti mosquitoes increases the ability of dengue virus to survive in the insects, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health. (infectioncontroltoday.com)
  • If this common fungus proves to have a significant impact on mosquitoes' ability to transmit dengue virus to people in endemic areas, then we can start to think about ways to translate this knowledge into specific anti-dengue strategies,' says George Dimopoulos, PhD, professor in the Bloomberg School's Department of Molecular Microbiology and Immunology. (infectioncontroltoday.com)
  • Dimopoulos and colleagues have discovered certain bacterial species that can live in mosquitoes and affect the insects' ability to transmit dengue and other diseases. (infectioncontroltoday.com)
  • In the new study, which stemmed from the same field project, Dimopoulos's team isolated a different type of fungus, from a species called Talaromyces, from the gut of dengue-carrying Aedes aegypti mosquitoes. (infectioncontroltoday.com)
  • The scientists fed spores of the fungus to Aedes mosquitoes via a sugar solution prior to a blood meal laced with dengue virus, and found that mosquitoes harboring the fungus were more likely to become infected by the virus. (infectioncontroltoday.com)
  • The dengue-infected mosquitoes that harbored the fungus also tended to have more dengue virus particles in their gut--meaning that the virus could survive and make copies of itself more easily when the fungus was present. (infectioncontroltoday.com)
  • The researchers then showed that this dengue-enabling effect was due to molecules that are secreted by fungal cells and reduce the activity of mosquitoes' digestive enzymes. (infectioncontroltoday.com)
  • It is possible that some of these incompatibilities between mosquitoes and dengue virus relate to this enzyme activity in the mosquito gut that can be modulated by fungi and other microbes,' Dimopoulos says. (infectioncontroltoday.com)
  • Talaromyces fungi are common, he adds, and are likely to be found in Aedes mosquitoes not just in Puerto Rico but globally, although further field studies are needed to demonstrate their influence over dengue transmission to human populations. (infectioncontroltoday.com)
  • Understanding this process, and why particular strains of dengue are more infectious to mosquitoes, is important to developing ways to contain the spread of these strains. (infectioncontroltoday.com)
  • Scientists are attributing this to climate change: the mosquitoes that transmit the virus to humans are able to expand their habitat thanks to increasing global warming. (uni-mainz.de)
  • The virus is transmitted by the tiger mosquito and other mosquitoes. (uni-mainz.de)
  • We started with dengue virus since it was highest on the list of possible transmission here in Houston because we have the right kind of mosquitoes and a very large, densely populated city full of frequent travel to endemic areas, including Mexico and Central and South America. (chron.com)
  • Dengue virus is spread through mosquitoes, similar to the way in which West Nile virus is transmitted. (chron.com)
  • These are the mosquitoes that are out during the middle of the day as opposed to those mosquitoes that carry West Nile virus, which are out predominantly between dusk and dawn. (chron.com)
  • Until a few hundred years ago, dengue virus was transmitted in sylvatic cycles in Africa, Southeast Asia and South Asia between mosquitoes of the genus Aedes and nonhuman primates, with rare emergences into human populations. (wikipedia.org)
  • The global spread of dengue virus, however, has followed its emergence from sylvatic cycles and the primary lifecycle now exclusively involves transmission between humans and Aedes mosquitoes. (wikipedia.org)
  • Genetically Engineered Mosquitoes that Resist Dengue Fever Virus! (ecofriend.org)
  • It is amazing that Aussie fruit bacteria can effectively immunise mosquitoes against dengue, thereby preventing its spread to humans," Professor Hoffmann said. (healthcanal.com)
  • Current control methods, mainly based on insecticides are failing to stop the global dengue problem and some mosquitoes are developing resistance. (healthcanal.com)
  • The resulting "hot spot" maps show regions of the world with high diversity of potential wildlife hosts of flaviviruses - viruses mostly spread by mosquitoes and ticks. (ucdavis.edu)
  • Mosquitoes of the Aedes albopictus species transmit various viruses, e.g. the dengue virus. (medicalxpress.com)
  • NS1 is detectable during the acute phase of dengue virus infections. (cdc.gov)
  • Cells expressing NS4B or infected with dengue virus do not exhibit nuclear signal transducer and activator of transcription (STAT) 1 on treatment with IFN-β or IFN-γ, indicating that NS4B might be involved in blocking IFN signaling during dengue virus infections. (pnas.org)
  • Dengvaxia prevents dengue infections slightly more than half the time. (yahoo.com)
  • In order to understand the molecular basis of dengue virus infections we explored the biochemical identity of dengue-2 (DEN-2) virus receptors in the Aëdes albopictus-derived cell line C6/36. (nih.gov)
  • Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement," Journal of Infectious Diseases , vol. 193, no. 8, pp. 1078-1088, 2006. (hindawi.com)
  • In subsequent dengue infections, where a different serotype of the virus is involved, the antibodies do not recognize enough of the virus to neutralize it. (medindia.net)
  • Although the virus is generally not life-threatening, evidence suggests that it may be responsible for recent increases in birth defects in Brazil and French Polynesia, where infections are more common. (livescience.com)
  • Dengue fever, caused by the dengue virus transmitted by the Aedes mosquito, is a serious global healthcare challenge which sees approximately 390 million infections annually. (eurekalert.org)
  • The drug may worsen future infections for people who haven't already been exposed to the virus. (the-scientist.com)
  • The World Health Organization estimates there may be 50-100 million dengue infections worldwide every year. (thaindian.com)
  • Jun 17, 2010 (CIDRAP News) The number of dengue virus infections detected in returning US travelers has risen sharply in recent years, probably reflecting both larger epidemics abroad and increased monitoring at home, the Centers for Disease Control and Prevention (CDC) reported today. (umn.edu)
  • However, many dengue infections cause no or only mild symptoms. (umn.edu)
  • About 1 in 20 dengue infections will progress to severe dengue, which presents with an increase in vascular permeability leading to a shock syndrome with a significant mortality risk. (constantcontact.com)
  • The number of annual dengue infections is now estimated between 50-100 million, with 24,000 deaths, primarily among children. (brandeis.edu)
  • Developing antivirals to treat dengue and related viral infections is no small task, and identifying targets that drugs can be developed against is critical. (ucsd.edu)
  • A study published the November 13, 2017, issue of Nature Communications by La Jolla Institute for Allergy and Immunology (LJI) investigator Sujan Shresta, Ph.D., now addresses interplay between dengue and ZIKV infections. (eurasiareview.com)
  • Globally, dengue incidence has increased 30-fold over the last 50 years, says the World Health Organisation (WHO), with 50-100 million infections reported annually in over 100 endemic countries, putting almost half of the world's population at risk. (hindustantimes.com)
  • The ICGEB hopes the vaccine will help the country achieve the WHO's goal of reducing dengue infections by at least 25% and dengue deaths by 50% by 2020. (hindustantimes.com)
  • Serious complications of dengue haemorrhagic fever (DHF) are more likely during secondary versus primary infections ( 2 , 3 ). (sciencemag.org)
  • Scientists have estimated that hundreds of millions of people suffer dengue virus infections--known as 'dengue fever'--in tropical regions each year. (infectioncontroltoday.com)
  • Dengue infections can involve severe joint and muscle pain and have also been termed 'breakbone fever. (infectioncontroltoday.com)
  • There are no vaccines yet for dengue virus, and there are no drugs to treat dengue infections," Hanley says. (infectioncontroltoday.com)
  • While a separate focus from the grant project, a goal of Hanley's lab is to identify drugs that may be useful in treating dengue virus infections. (infectioncontroltoday.com)
  • Dengue Virus Disease: From Origin to Outbreak provides a detailed accounting of one of the world's fastest growing infections. (researchandmarkets.com)
  • According to the World Health Organization, Dengue virus incidence has increased 30-fold over the past 50 years, with up to 50 to 100 million infections occurring annually in over 100 endemic countries. (researchandmarkets.com)
  • This book reviews the history, clinical and diagnostic aspects of dengue virus, also presenting our current knowledge on the pathophysiology of severe dengue and addressing the importance of dengue virus infections in those traveling to parts of the world where it is endemic. (researchandmarkets.com)
  • Kaptein SJ, Neyts J (2016) Towards antiviral therapies for treating dengue virus infections. (springer.com)
  • Early diagnosis of dengue infections is crucial to increasing survival rates, according to the World Health Organization . (pewtrusts.org)
  • Current estimates indicate that as many as 390 million infections occur each year, and many dengue infections are increasingly understood to be asymptomatic or subclinical. (wikipedia.org)
  • We examined the modulation of endothelial barrier function in dengue virus type 2 (DENV2) infections using primary human umbilical vein endothelial cells. (biomedsearch.com)
  • Dengue virus infections produce a wide spectrum of clinical illness. (biomedsearch.com)
  • Dengue is the most prevalent arboviral disease affecting humans, with tropical and subtropical regions having the highest risk of dengue virus infections. (go.jp)
  • Dengue virus infections have a three to 14-day window period before symptoms appear. (blood.ca)
  • however the involvement of platelets in dengue virus infections is unclear. (blood.ca)
  • It has been known for a long time that these antibodies can enhance subsequent dengue infections under certain conditions. (medicalxpress.com)
  • Most of these tests use synthetically labeled antibodies to detect dengue NS1 protein. (cdc.gov)
  • People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure. (cdc.gov)
  • S. B. Halstead, "Antibodies determine virulence in Dengue," Annals of the New York Academy of Sciences , vol. 1171, no. 1, pp. (hindawi.com)
  • La Jolla Institute scientists have proved a hypothesis that said antibodies contribute to severe dengue virus-induced disease. (medindia.net)
  • La Jolla Institute scientist Sujan Shresta said: "Our lab has proven the decades old hypothesis that subneutralizing levels of dengue virus antibodies exacerbate the disease. (medindia.net)
  • It also presents a special challenge for researchers working to develop a dengue virus vaccine, since most vaccines work by prompting the body to produce antibodies. (medindia.net)
  • Dr. Halstead agreed and said: "The vaccine should cause you to make antibodies to each of the four dengue viruses. (medindia.net)
  • In a paper published today in the Proceedings of the National Academy of Sciences, the researchers, from MIT's Koch Institute of Integrative Cancer Research, present a novel approach to developing a dengue therapy using mutated antibodies. (innovations-report.com)
  • However, the antibodies that target the loop region tend to have low potency, meaning they are unable to completely neutralize the virus. (innovations-report.com)
  • Cases were classified as probable if the patient had elevated dengue antibodies but the virus wasn't tested for or detected. (umn.edu)
  • In this study, we have generated a panel of human monoclonal antibodies to dengue virus. (sciencemag.org)
  • Recombinant domains of the E protein are used as well-defined antigens in the serological detection of antibodies directed against dengue virus and as immunogens in vaccine candidates. (wikipedia.org)
  • Characterization and epitope mapping of Dengue virus type 1 specific monoclonal antibodies. (sigmaaldrich.com)
  • One dengue fever vaccine, Dengvaxia, is currently approved for use in those ages 9 to 45 who live in areas with a high incidence of dengue fever. (yahoo.com)
  • The vaccine is approved only for older children because younger vaccinated children appear to be at increased risk of severe dengue fever and hospitalization two years after receiving the vaccine. (yahoo.com)
  • The World Health Organization stresses that the vaccine is not an effective tool, on its own, to reduce dengue fever in areas where the illness is common. (yahoo.com)
  • This ability to morph helps the virus evade the immune system of the human host, and understanding the mechanism behind this transformation is important for therapeutics and vaccine development, the researchers mentioned. (indiatimes.com)
  • There is currently no vaccine to prevent Dengue virus. (drugs.com)
  • The findings of the La Jolla Institute for Allergy and Immunology have major implications for efforts to develop a first-ever vaccine against the dangerous infectious dengue disorder. (medindia.net)
  • Scientists had long complained that the lack of a good animal model hampered efforts to develop a first-ever dengue vaccine. (medindia.net)
  • Dr. Shresta said her group's ADE findings emphasize the importance of special caution in designing a dengue virus vaccine. (medindia.net)
  • She said: "Researchers will have to be extremely careful to ensure that, under no conditions, will a dengue vaccine generate these subneutralizing antibody conditions. (medindia.net)
  • Despite the serious socio-economic impact of dengue-associated diseases, the only licensed vaccine has limited efficacy and an antiviral therapy is not available. (eurekalert.org)
  • While a vaccine against the virus is recently available commercially, its effectiveness is limited as it is not effective against all the four dengue viral subtypes, and there are no alternative therapeutics yet. (eurekalert.org)
  • Despite the threat posed by the disease, developing a vaccine against dengue has so far proved challenging, according to Ram Sasisekharan, the Alfred H. Caspary Professor of Biological Engineering at MIT. (innovations-report.com)
  • Linda Heston, Mironda's mother, says she's thrilled that Brandeis University is continuing to focus on work that will encourage the creation of a vaccine or other solutions to control or eliminate dengue in the U.S. and around the world, so other families do not have to go through what their family has. (brandeis.edu)
  • A decade later, in 2001, Halstead convened a meeting in Korea that gave rise to creating the Pediatric Dengue Vaccine Initiative (PDVI). (brandeis.edu)
  • Initially supported by the Bill and Melinda Gates Foundation -- through PDVI -- subsequent dengue research at Brandeis has been supported by Sanofi Pasteur , a research-based vaccine company based in France. (brandeis.edu)
  • There have been indications that vaccination against dengue can worsen the symptoms of the virus if the vaccine is given to people who have not had the virus previously," said Brian Geiss, associate professor of microbiology at Colorado State and co-author of the study. (ucsd.edu)
  • India has developed an indigenous vaccine candidate that is effective against all four strains of dengue in the pre-clinical phase. (hindustantimes.com)
  • We propose that the partial cleavage of prM from the viral surface reduces the density of antigen available for viral neutralization, leaving dengue viruses susceptible to ADE by antibody to prM, a finding that has implications for future vaccine design. (sciencemag.org)
  • Just like Ebola, dengue fever is also caused by a virus for which there is currently no cure and no vaccine and can be fatal. (uni-mainz.de)
  • To date, there is no vaccine and no way of fighting the dengue virus with specific drugs. (uni-mainz.de)
  • SAN DIEGO , Sept. 24, 2014 /PRNewswire/ -- Aethlon Medical, Inc. (OTCQB: AEMD), the pioneer in developing targeted therapeutic devices to address infectious disease, cancer and other life-threatening conditions, announced today that it has entered into an agreement with Qualtran, LLC that would expand human clinical studies of Hemopurifier® therapy to include individuals infected with dengue virus, a global health threat, which is not addressed with approved drug or vaccine therapies. (bio-medicine.org)
  • The only dengue vaccine available in the market, CYD-TDV offers limited coverage for vaccinees from 9-45 years of age and is only recommended for individuals with prior dengue exposure. (medsci.org)
  • This review hopes to provide information leading to the construction of a live attenuated dengue vaccine that is suitable for all ages, irrespective of the infecting dengue serotype and prior dengue exposure. (medsci.org)
  • Dengue vaccine is a vaccine used to prevent dengue fever in humans. (wikipedia.org)
  • The vaccine is only recommended in those who have previously had dengue fever or populations in which most people have been previously infected. (wikipedia.org)
  • The value of the vaccine is limited by the fact that it may increase the risk of severe dengue in those who have not previously been infected. (wikipedia.org)
  • The safety and effectiveness of the vaccine was determined in three randomized, placebo-controlled studies involving approximately 35,000 individuals in dengue-endemic areas, including Puerto Rico, Latin America and the Asia Pacific region. (wikipedia.org)
  • The vaccine was determined to be approximately 76 percent effective in preventing symptomatic, laboratory-confirmed dengue disease in individuals 9 through 16 years of age who previously had laboratory-confirmed dengue disease. (wikipedia.org)
  • Dr. Halstead and his colleague Dr. Phillip Russell proposed that the vaccine only be used after antibody testing, to rule out prior dengue exposure and avoid vaccination of sero-negative individuals. (wikipedia.org)
  • Dengvaxia is a weakened but live vaccine and works by triggering an immune response against four types of dengue virus. (wikipedia.org)
  • The World Health Organization (WHO) recommends that countries should consider vaccination with the dengue vaccine CYD-TDV only if the risk of severe dengue in seronegative individuals can be minimized either through pre-vaccination screening or recent documentation of high seroprevalence rates in the area (at least 80% by age nine years). (wikipedia.org)
  • The team monitored the changes that the dengue virus undergo in three different conditions, namely: when it is inside the Aedes mosquito, when it is inside a healthy human, and when it is inside a patient suffering from dengue fever. (eurekalert.org)
  • Dengue virus - transmitted by the mosquito Aedes aegypti - infects millions of people across Asian and Latin American countries, according to the WHO (Geneva, Switzerland). (biotechniques.com)
  • Strains of a bacterium commonly found in fruit flies can prevent the Aedes aegypti mosquito from transmitting the virus that causes dengue fever, researchers have found. (innovations-report.com)
  • The program aims to stop the Aedes aegypti mosquito from transmitting dengue virus between humans by introducing a naturally occurring bacterium called Wolbachia - which is not harmful to humans - into the existing wild mosquito population. (innovations-report.com)
  • Dengue is transmitted to humans by the mosquito Aedes aegypti (rarely Aedes albopictus). (abcam.com)
  • An Aedes aegypti -associated fungus increases susceptibility to dengue virus by modulating gut trypsin activity' was written by Yesseinia Angleró-Rodríguez, Octavio Talyuli, Benjamin Blumberg, Seokyoung Kang, Celia Demby, Alicia Shields, Jenny Carlson, Natapong Jupatanakul, and George Dimopoulos. (infectioncontroltoday.com)
  • Dengue virus is transmitted by species of the mosquito genus Aedes. (wikipedia.org)
  • The mosquito that transmits chikungunya-the Aedes aegypti-is the same one that spreads dengue. (medicalxpress.com)
  • In Myanmar, dengue is endemic. (nsf.gov)
  • FACTS: Dengue fever is a tropical disease endemic to more than 100 countries. (giantmicrobes.com)
  • Recently, dengue virus emerged as a prime suspect because it shares many genetic and structural characteristics with ZIKV and is endemic in most of the regions affected by Zika's global spread. (eurasiareview.com)
  • Dengue virus is endemic many parts of Asia, Africa and the Americas, infecting up to 100 million people globally each year . (theconversation.com)
  • When researchers looked at the medical records of these patients and conducted interviews, they found that most did not have a history of travel to endemic areas, indicating that the virus is being transmitted locally. (chron.com)
  • The virus is endemic in more than 100 countries and it is known to have infected 390 million worldwide and has resulted in up to 500,000 cases of the potentially fatal haemorrhagic fever. (surrey.ac.uk)
  • Nowadays, dengue is endemic in more than 100 countries. (sophia.org)
  • Dengue is endemic in the U.S. territories of American Samoa, Guam, Puerto Rico and the U.S. Virgin Islands. (wikipedia.org)
  • Researchers in UC San Diego Associate Professor Omar Akbari's lab worked with colleagues at Vanderbilt University Medical Center in identifying a broad spectrum human antibody for dengue suppression. (newswise.com)
  • The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. (newswise.com)
  • It will allow us to study the virus and the antibody enhancement in ways never before possible. (medindia.net)
  • Mouse monoclonal antibody prepared against the envelope glycoprotein of Dengue virus type 4 was purified from clone E2 hybridoma supernatant by protein G affinity chromatography. (atcc.org)
  • Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification. (atcc.org)
  • Mouse monoclonal antibody prepared against the envelope glycoprotein of dengue virus type 4 was purified from clone E62 hybridoma supernatant by protein G affinity chromatography. (atcc.org)
  • They have located a human antibody that can neutralise and kill its virus within two hours. (thaindian.com)
  • Significantly, they have also identified a way to reproduce this antibody in large quantities, potentially opening the door to a cure for dengue infected patients. (thaindian.com)
  • By studying a group of cell lines from recovered dengue-infected patients over two years, the team identified the antibody, could attach itself strongly to a specific part of the dengue virus and inhibit it from attacking other cells. (thaindian.com)
  • The antibody eventually destroys the virus and at a much faster speed compared to existing anti-dengue compounds. (thaindian.com)
  • Efforts to develop a therapeutic antibody for dengue are focused on a part of the virus called the envelope protein. (innovations-report.com)
  • The researchers chose as their model an antibody known as 4E11, which has been shown in tests to neutralize dengue 1, 2 and 3, but not dengue 4. (innovations-report.com)
  • We wanted to see if we could get good neutralizing activity to dengue 4, and also tweak the antibody to increase the potency associated with the other subtypes," Sasisekharan says. (innovations-report.com)
  • This significantly narrowed the number of possible changes, or mutations, the researchers needed to make antibody 4E11 in order to improve its ability to neutralize all four viruses, in particular dengue 4. (innovations-report.com)
  • By learning and validating data from numerous three-dimensional structures of interacting antibody and protein complexes, the researchers gained valuable insights that enabled them to redesign a dengue virus envelope antibody to improve its binding by an astounding 450-fold," Vasudevan says. (innovations-report.com)
  • Our new work suggests that vaccines targeting either virus could be engineered to induce both T cell and antibody responses effective to protect people in these areas. (eurasiareview.com)
  • Today, anti-dengue vaccines that primarily evoke antibody responses are in clinical trials or starting to be licensed in certain countries but show only moderate success. (eurasiareview.com)
  • Dengue Virus NS2B Polyclonal antibody specifically detects Dengue Virus NS2B in Virus samples. (fishersci.com)
  • The following antibody was used in this experiment: Dengue Virus Type 2 NS3 Monoclonal Antibody (GT2811) from Thermo Fisher Scientific, catalog # MA5-17297, RRID AB_2538763. (thermofisher.com)
  • Dengue is one of the most important emerging vector-borne viral diseases. (biomedcentral.com)
  • Although dengue virus-infected cells seem to be resistant to the antiviral action of IFN, the viral products that mediate this resistance are unknown. (pnas.org)
  • The onset of the IFN-α/β response in virus-infected cells presumably occurs on viral entry and release/synthesis of viral components, including double-stranded RNA (dsRNA) intermediates. (pnas.org)
  • This difference was exploited to demonstrate, absent manipulation of the viral genome, that NS5-mediated IFN antagonism is essential for efficient virus replication. (nih.gov)
  • THURSDAY, March 14 (HealthDay News) -- Some people who fell prey to a 2009-2010 outbreak of dengue fever in Florida carried a particular viral strain that they did not bring into the country from a recent trip abroad, according to a fresh genetic analysis conducted by the U.S. Centers for Disease Control and Prevention. (medicinenet.com)
  • The CDC's viral fingerprinting of Key West, Fla., dengue patients therefore raises the specter that a disease more commonly found in parts of Africa, the Caribbean, South America and Asia might be gaining traction among North American mosquito populations. (medicinenet.com)
  • Dengue fever is the most widespread mosquito-borne viral disease in the world, now found in roughly 100 countries, the study authors noted. (medicinenet.com)
  • Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining," American Journal of Tropical Medicine and Hygiene , vol. 80, no. 3, pp. 416-424, 2009. (hindawi.com)
  • The nonstructural protein 1 (NS1) of the dengue virus interacts with another viral protein called NS4A-2K-4B to enable viral replication, according to a study published May 9 in the open-access journal PLOS Pathogens by Ralf Bartenschlager of the University of Heidelberg, and colleagues. (eurekalert.org)
  • The authors add, "A detailed study of nonstructural protein 1 of Dengue virus identified determinants required for secretion of this protein, viral RNA replication and formation of the membranous replication organelle of this virus. (eurekalert.org)
  • 2019) A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle. (eurekalert.org)
  • To block the viral outbreaks, the NUS research team, which also comprises Professor Thorsten Wohland, Associate Professor Lok Shee-Mei, Dr Arun Chandramohan and Mr Lim Xin-Xiang, sought to identify new approaches to tackle the dengue virus. (eurekalert.org)
  • Dengue illness, the most common mosquito-borne viral disease in the world, has expanded from its Southeast Asian origins and is resurgent in countries such as Argentina, Chile and the continental United States. (brandeis.edu)
  • A "DNA star" is perfectly configured to latch onto Dengue virus in the bloodstream, and could be a new diagnostic and therapeutic approach for many viral diseases. (newswise.com)
  • He also attached specific aptamers - molecules the viral latches will bind to - precisely to the tips and vertices of the star so that they would align with the distribution of the latches on the virus. (newswise.com)
  • As described in the current edition of PLOS Computational Biology , the simulations home in on a small segment of a viral enzyme called non-structural protein 3 (NS3), that plays a critical role in replicating the dengue RNA genome, which the virus requires to survive and spread. (ucsd.edu)
  • Kerala is in the grip of dengue, the mosquito-borne viral fever that causes high fever, muscle and joint pain, and death from shock. (hindustantimes.com)
  • NS1 is one of 7 Dengue Virus non-structural proteins which are thought to be involved in viral replication. (abcam.com)
  • Previous work from this acclaimed team discovered that the dengue virus infects cells, altering their function and forcing them to produce high quantities of viral proteins which are responsible for transmitting the virus throughout the body. (surrey.ac.uk)
  • The company is now preparing to launch the IDE approved feasibility study, which will contribute safety data to advance the Hemopurifier® as a broad-spectrum countermeasure against chronic viral pathogens such as HIV and HCV, and high-risk bioterror or pandemic threats such as dengue and ebola virus. (bio-medicine.org)
  • Recombinant Viral Dengue Virus 1 N. (novusbio.com)
  • The World Health Organisation ranks dengue fever as the most important mosquito-borne viral disease in the world, with an estimated 2.5 billion people living in dengue infected areas. (healthcanal.com)
  • Managing dengue naturally: A review of plant-based treatments with anti-viral effects. (naturalnews.com)
  • The researchers investigated the hypothesis that dengue virus enters platelets and, once inside, uses each platelet's cellular machinery to produce viral proteins and replicate the virus' genetic material - its genome. (blood.ca)
  • The dengue virus genome is replicated and dengue viral proteins are synthesized by platelets. (blood.ca)
  • Researchers are working on dengue fever vaccines. (yahoo.com)
  • HOUSTON: The mosquito-borne deadly dengue virus that infects about 400 million people globally every year - especially in the tropic and sub-tropic regions of the world - is undergoing changes that are helping it evade vaccines and therapeutics, according to a study. (indiatimes.com)
  • With no approved vaccines or specific treatment available, dengue continues to be a public health concern. (thaindian.com)
  • That information should help researchers trying to develop vaccines against the mosquito-borne virus, which is nicknamed "break-bone fever" for the joint pain it causes. (umass.edu)
  • Progress towards producing safe, effective dengue virus vaccines, a goal for over 45 years, has been made. (asm.org)
  • After you've recovered from dengue fever, you have immunity to the type of virus that infected you - but not to the other three dengue fever virus types. (yahoo.com)
  • This is a simple, non-chemical, non-harmful way to reduce the threat of dengue to humans," Lloyd says. (innovations-report.com)
  • Rigorous genetic testing revealed what researchers feared: the identification of a local Key West strain among dengue patients who had not recently traveled outside the United States. (medicinenet.com)
  • The researchers also demonstrated that NS1 is required for the generation of the membranous dengue virus replication organelle in infected cells. (eurekalert.org)
  • A team of researchers from the National University of Singapore (NUS) has uncovered hidden vulnerabilities on the surface of the dengue virus. (eurekalert.org)
  • Lloyd contributed mathematical models that helped the researchers interpret the results of their experiments, which pointed to the wMel strain as the bacterium with the greater potential for suppressing the spread of dengue virus. (innovations-report.com)
  • The economic burden of dengue (pronounced DENgee) in the Western Hemisphere, according to a new study from Brandeis University researchers published today in the American Journal of Tropical Medicine and Hygiene , is approximately $2.1 billion per year. (brandeis.edu)
  • Newswise - TROY, N.Y. - By folding snippets of DNA into the shape of a five-pointed star using structural DNA nanotechnology, researchers have created a trap that captures Dengue virus as it floats in the bloodstream. (newswise.com)
  • Over the past couple of decades, researchers around the world have considered NS3 a primary target for developing drugs capable of inhibiting and preventing the replication of the dengue virus. (ucsd.edu)
  • Three decades ago researchers identified NS3 as crucial to the virus' survival. (ucsd.edu)
  • He notes that although many mosquito species feed on human blood, most are not infected by or don't transmit dengue virus--for reasons that researchers have never fully understood. (infectioncontroltoday.com)
  • In order to capture all of the elements that shape transmission, particularly for insect-transmitted viruses like dengue, researchers have to understand both the insect-virus and human-virus interaction. (infectioncontroltoday.com)
  • Researchers from Johannes Gutenberg University Mainz (JGU) and the Julius Maximilian University of Würzburg are proposing potential new active substances for treating the dengue virus. (uni-mainz.de)
  • HOUSTON - In a retrospective study of three years of blood and cerebrospinal fluid samples submitted for West Nile virus testing in the Houston area, researchers at the National School of Tropical Medicine at Baylor College of Medicine found that 47 of the samples were positive for dengue virus. (chron.com)
  • Researchers from the University of Surrey have been awarded £750,000 from the prestigious Biotechnology and Biological Sciences Research Council to shed further light on the deadly dengue virus. (surrey.ac.uk)
  • Working in collaboration with academics from the University of Cambridge, Surrey researchers will investigate the mechanics of the mosquito-borne dengue virus and how it instigates increased protein production in cells. (surrey.ac.uk)
  • During this ground breaking study researchers will examine how this process occurs, potentially leading to the development of new techniques to stop the virus replicating and spreading through the body. (surrey.ac.uk)
  • According to the study, the researchers first compared the genomes of all known dengue viruses in Brazil. (naturalnews.com)
  • In Mexico, Fogarty-supported researchers have 'for years worked with different types of intervention strategies to reduce the amount of transmission of dengue, specifically in people's homes,' said Dr. Bill Black, a professor of vector biology and parasitology at Colorado State University (CSU) and the principal investigator on a Fogarty training grant in dengue prevention and control. (nih.gov)
  • Next, the researchers investigated what would happen if blood components became infected with dengue virus. (blood.ca)
  • This was to enable the researchers to find out whether perhaps dengue viruses in northeastern Brazil had caused different immunity compared to the immunity observed in other regions in Brazil over the last decades. (medicalxpress.com)
  • Dengvaxia is not approved in the U.S. for use in individuals not previously infected by any dengue virus serotype or for whom this information is unknown. (wikipedia.org)
  • We and others have reported that autophagy is induced by dengue viruses (DVs) in various cell lines, and that it plays a supportive role in DV replication. (biomedcentral.com)
  • Macrophages (Mϕ) are the major source of inflammatory cytokines and aretarget cells for dengue virus (DV) replication. (biomedcentral.com)
  • We found that expression in human A549 cells of the dengue virus nonstructural proteins NS2A, NS4A, or NS4B enhances replication of an IFN-sensitive virus. (pnas.org)
  • Mouse STAT2 restricts early dengue virus replication. (nih.gov)
  • By using STAT2(-/-) mice, we also demonstrate that mouse STAT2 restricts early dengue virus replication in vivo. (nih.gov)
  • Virus replication levels were recorded 12hpi by live microscopy. (nih.gov)
  • RNA viruses encode the information required for their replication in both their primary sequences and higher-order structures formed when the RNA genome strand folds back on itself, but the extent of higher-order structure has remained unclear. (pnas.org)
  • We use a new high-throughput RNA structure probing technology to identify RNA regions with tertiary folds and discover that roughly one-third of the dengue virus RNA genome forms higher-order interactions, many in regions functionally important for replication. (pnas.org)
  • RNA virus genomes are efficient and compact carriers of biological information, encoding information required for replication both in their primary sequences and in higher-order RNA structures. (pnas.org)
  • A novel interaction of NS1 with a previously unrecognized NS4A-2K-NS4B precursor of the virus was found to be required for Dengue virus replication. (eurekalert.org)
  • To date, there are no approved drugs that can stop the replication or spread of the virus. (ucsd.edu)
  • Previous studies have shown that when NS3 is mutated, the enzyme's role in genome replication is curtailed and the virus cannot make copies of its genome, demonstrating NS3's importance in the virus' life cycle. (ucsd.edu)
  • Inhibition of protein kinase C promotes dengue virus replication. (sigmaaldrich.com)
  • Kakumani PK, Ponia SS, Rajgokul KS, Sood V, Chinnappan M, Banerjea AC, Medigeshi GR, Malhotra P, Mukherjee SK, Bhatnagar RK (2013) Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor. (springer.com)
  • Low oxygen tension exerts a profound effect on the replication of several DNA and RNA viruses. (mdpi.com)
  • Inhibition of dengue virus replication by diisopropyl chrysin-7-yl phosphate. (greenmedinfo.com)
  • Well, all the symptoms that're caused by viruses is because of their capsule protein which are synthesized during replication. (biology-online.org)
  • Chikungunya virus occupies a similar geographic distribution as dengue, and can have a similar febrile illness presentation. (constantcontact.com)
  • A worker fumigates as part of awareness campaign for dengue and chikungunya at Khurezi in East Delhi. (hindustantimes.com)
  • Vector-borne disease top our surveillance list during monsoon, and the dengue outbreaks will be bigger this year compared to chikungunya," said an official at the National Centre for Disease Control, who did not want to be named because he's not authorised to speak to the media. (hindustantimes.com)
  • Chikungunya produces symptoms similar to dengue , including high fever, joint pain and skin rash. (medicalxpress.com)
  • For viruses to productively infect their hosts, they must evade or inhibit important elements of the innate immune system, namely the type I interferon (IFN) response, which negatively influences the subsequent development of antigen-specific adaptive immunity against those viruses. (mdpi.com)
  • Morrison J, Aguirre S, Fernandez-Sesma A. Innate Immunity Evasion by Dengue Virus. (mdpi.com)
  • Dengue virus infects some 50-100 million people annually in Southeast Asia, South America and parts of the United States. (nsf.gov)
  • Dengue infects 5 percent of the world's population each year, and its range is increasing. (umass.edu)
  • Recent findings suggest that as the virus infects human cells, host homeostatic processes such as autophagy and ER stress response, not to mention apoptosis, are triggered depending on the infected cell type. (wikipedia.org)
  • So, there is potential for the dengue virus to be transmitted locally, and cause dengue outbreaks like the ones we saw in Key West in 2009 and 2010," he said. (medicinenet.com)
  • Dengue outbreaks were recorded in China during autochthonous dengue virus transmission in Wenzhou. (cdc.gov)
  • In contrast, there are large and ongoing outbreaks of dengue virus in many parts of the world. (constantcontact.com)
  • We're hoping that if we can understand the factors that influence dengue transmission, we can better predict when particularly nasty outbreaks of dengue are going to happen," Hanley said. (infectioncontroltoday.com)
  • NS1 tests detect the non-structural protein NS1 of dengue virus. (cdc.gov)
  • This protein, encoded by a positive strand RNA virus, is implicated as an IFN-signaling inhibitor. (pnas.org)
  • This is a very critical protein that allows the virus to latch on to the appropriate receptor within the host, to infect them, replicate and spread," Sasisekharan says. (innovations-report.com)
  • The structural precursor-membrane protein (prM) is a 166-amino-acid protein intimately associated in a 1:1 fashion with domain II of E ( 7 ) and is believed to act as a chaperone for the folding of E and to prevent the premature fusion of virus to membranes inside the producing cell. (sciencemag.org)
  • Culture supernatants were screened against structural antigens by using whole virus and against nonstructural protein 1 (NS1) by means of enzyme-linked immunosorbent assay (ELISA). (sciencemag.org)
  • Full length native protein purified from Dengue Virus 2 (16681) infected supernatant. (abcam.com)
  • The virus has a protective envelope called a capsid that is protein-based, so it is possible that this capsid is susceptible to some of these mosquito-gut enzymes. (infectioncontroltoday.com)
  • Dengue virus is coated by an icosahedral shell of 90 envelope protein dimers that convert to trimers at low pH and promote fusion of its membrane with the membrane of the host endosome. (osti.gov)
  • Combined continuum and molecular dynamics results predict a 15 kcal/mol free energy decrease on binding of each trimer of dengue envelope protein to a membrane with 30% anionic phosphatidylglycerol lipid. (osti.gov)
  • The E.Coli derived recombinant protein contains the NS1 Dengue Virus full length Type-2 immunodominant regions, having an Mw of 45kDa. (prospecbio.com)
  • The dengue protein is fused to 6xHis tag at C-terminus and purified by proprietary chromatographic technique. (prospecbio.com)
  • The E.coli derived recombinant protein contains the NS1 Dengue Virus n-end Type-2 immunodominant regions. (prospecbio.com)
  • Dengue protein is purified by proprietary chromatographic technique. (prospecbio.com)
  • Bussetta C, Choi KH (2012) Dengue virus nonstructural protein 5 adopts multiple conformations in solution. (springer.com)
  • Dengue fever and dengue hemorrhagic fever (DHF) are acute febrile diseases, found in the tropics, with a geographical spread similar to malaria. (abcam.com)
  • An illustration of the dengue virus (Flaviviridae), which causes dengue fever and dengue hemorrhagic fever. (sciencephoto.com)
  • Dengue fever and dengue hemorrhagic fever are acute febrile diseases, found in the tropics and Africa. (thermofisher.com)
  • 50 other members including West Nile (WN) and yellow fever (YF) viruses have been identified. (pnas.org)
  • Is West Nile virus the same as dengue? (yahoo.com)
  • A team including Purdue University's Michael Rossmann and Richard Kuhn has solved the structure of the immature dengue virus, which is related to West Nile virus and yellow fever. (purdue.edu)
  • Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. (nature.com)
  • West Nile virus homepage. (nature.com)
  • Centers for Disease Control and Prevention 〈 http://www.cdc.gov/ncidod/dvbid/dengue 〉 (2005). (nature.com)
  • One of them, Asia represents 70% of the global burden of dengue fever. (sophia.org)
  • The global burden of dengue virus is considerable: Approximately 2.5 billion people are at risk and almost 400 million people are infected every year - about 25,000 die. (blood.ca)
  • Many people, especially children and teens, may experience no signs or symptoms during a mild case of dengue fever. (yahoo.com)
  • It is in examining the changes a virus undergoes for example, in the case of dengue, how it uncaps its fusion peptides to become an infectious agent that the team hopes to find clues to stopping the developmental process in its tracks. (purdue.edu)
  • Viruses enter the host's cells and use the cell's internal machinery to replicate their own genetic material (in the case of dengue, singlestranded RNA). (blood.ca)
  • To date, most cases of dengue fever on American soil have typically involved travelers who "import" the painful mosquito-borne disease after having been bitten elsewhere. (medicinenet.com)
  • In 1998, a pandemic of dengue resulted in 1.2 million cases of dengue hemorrhagic fever in 56 countries. (nsf.gov)
  • There are up to 50 million cases of dengue estimated each year resulting in 500,000 hospitalizations and 20,000 deaths. (biomedsearch.com)
  • The dengue fever is a relatively mild febrile illness with rash whereas the dengue hemorrhagic fever is a more severe, sometimes lethal disease. (pnas.org)
  • Severe dengue is a leading cause of serious illness and death among children in many Asian and Latin American countries. (newswise.com)
  • Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity," Journal of Infectious Diseases , vol. 179, no. 4, pp. 755-762, 1999. (hindawi.com)
  • Early clinical and laboratory indicators of acute dengue illness," Journal of Infectious Diseases , vol. 176, no. 2, pp. 313-321, 1997. (hindawi.com)
  • In 2014, 20 dengue cases were reported in the cities of Wenzhou(5cases)andWuhan(15cases),China,where The Study denguehasrarelybeenreported.Denguevirus1wasde- tected in 4 patients.Although most of these cases were During July-November 2014, a total of 20 suspected cases likely imported, epidemiologic analysis provided evidence of illness were clinically diagnosed as dengue in Wenzhou (5 forautochthonoustransmission. (cdc.gov)
  • Dengue is a mosquito-borne illness that can cause debilitating sickness and death. (thaindian.com)
  • Dengue virus is detectable by NAAT from the start of fever until 7-10 days after illness onset. (constantcontact.com)
  • Dengue hemorrhagic fever, the more severe dengue illness, may put a patient into shock and lead to death. (brandeis.edu)
  • Yara Halasa , a research associate at the Heller School's Schneider Institute for Health Policy and one of the co-authors with Shepard on the "Economic Impact of Dengue Illness in the Americas," has been involved with the dengue project for three years. (brandeis.edu)
  • The virus is usually a self-limiting illness. (chron.com)
  • This particular strain of dengue virus can be associated with severe illness, including hemorrhagic fever. (chron.com)
  • None of the medical records of any of the cases listed dengue as a possible cause of the illness. (chron.com)
  • This spectrum ranges from asymptomatic or mild illness to a severe and potentially life-threatening disease, dengue hemorrhagic fever (DHF). (biomedsearch.com)
  • In more severe or complicated dengue, patients present with a severe febrile illness characterized by abnormalities of hemostasis and increased vascular permeability, which in some instances results in a hypovolemic shock. (asm.org)
  • 1 Dengue viruses (DENVs) are single-stranded, positive-sense, RNA-containing enveloped viruses belonging to the family Flaviviridae and the genus Flavivirus . (biomedsearch.com)
  • A severe form of dengue fever, also called dengue hemorrhagic fever, can cause severe bleeding, a sudden drop in blood pressure (shock) and death. (yahoo.com)
  • This can cause a severe form of dengue fever, called dengue hemorrhagic fever, severe dengue or dengue shock syndrome. (yahoo.com)
  • Otherwise, it could cause people to develop the severest and potentially lethal form of the disease -- dengue hemorrhagic fever/dengue shock syndrome. (medindia.net)
  • Exposure to different strains or concurrently getting infected with two strains make it likelier for a person to get dengue haemorrhagic fever, a severe form of dengue that can lead to death due to circulatory shock and multi-organ failure. (hindustantimes.com)
  • The other fatal case did have a history of recent travel to Mexico, and clinical symptoms were compatible with dengue hemorrhagic fever and shock syndrome. (chron.com)
  • In a small proportion of patients, the disease can exacerbate and progress to dengue hemorrhagic fever and/or dengue shock syndrome, characterized by severe vascular leakage, thrombocytopenia, and hemorrhagic manifestations. (frontiersin.org)
  • In some infected persons a milder form, dengue fever (DF), may develop, whereas in a smaller proportion, the severe disease, dengue hemorrhagic fever (DHF), develops, which is characterized by an excessive capillary permeability that may lead to shock (dengue shock syndrome [DSS]) and death. (thefreelibrary.com)
  • Dengue (DENG-gey) fever is a mosquito-borne disease that occurs in tropical and subtropical areas of the world. (yahoo.com)
  • Dengue fever is most common in Southeast Asia and the western Pacific islands, but the disease has been increasing rapidly in Latin America and the Caribbean. (yahoo.com)
  • Factors that put you at greater risk of developing dengue fever or a more severe form of the disease include: 1. (yahoo.com)
  • 4 days ago · Dengue fever is a mosquito-borne tropical disease caused by the dengue virus . (yahoo.com)
  • Every year more countries add another one of the dengue virus subtypes to their lists of locally transmitted viruses, and this could be the case with Florida," said Munoz-Jordan, chief of CDC's molecular diagnostics activity in the dengue branch of the division of vector-borne disease. (medicinenet.com)
  • Evidence of vascular damage in dengue disease: demonstration of high levels of soluble cell adhesion molecules and circulating endothelial cells," Endothelium , vol. 13, no. 5, pp. 335-340, 2006. (hindawi.com)
  • But it now appears that defective viruses may be able to play a critical role in the spread of disease. (nsf.gov)
  • The origin of the name Dengue is unknown, but is thought to derive from the Swahili "ka-dinga pepo" (or "disease of the devil") corrupted to the Spanish word "dengue" which described the "fastidious" gait exhibited by sufferers as they walk. (giantmicrobes.com)
  • In addition, because Dengue virus attacks white blood cells and can compromise platelet production, it can also cause the hemorrhages which distinguish the disease from other tropical afflictions such as malaria and typhoid fever. (giantmicrobes.com)
  • Dengue is a nasty disease, and right now, there is no treatment for it and no way to prevent it," said Mariano Garcia-Blanco, professor of molecular genetics and microbiology at Duke University Medical Centre (DUMC) and study co-author. (thaindian.com)
  • Reports of US dengue cases may continue to increase, since, as the report noted, the CDC added the mosquito-borne disease to the list of nationally notifiable diseases in January. (umn.edu)
  • A more severe form of the disease is dengue hemorrhagic fever, which can lead to circulatory failure and death. (umn.edu)
  • Shepard's research, which related the economic burdens and the controlling of dengue, was part of the Disease Control Priorities Project , which was published by the World Bank in 1993. (brandeis.edu)
  • It has spread into Brazil/Latin America and is moving into places in Asia where people previously had dengue," says Shresta, an associate professor in LJI's Center for Infectious Disease. (eurasiareview.com)
  • However, infants between 5 and 8 months of age are at a high risk for severe disease, as are those who have been exposed to dengue virus previously. (chron.com)
  • People who have had dengue once and are exposed to a different type of dengue virus have a high risk of developing hemorrhagic fever, an incredibly severe form of the disease. (chron.com)
  • The ability of some dengue-specific Abs to promote the entry of the virus into Fc receptor-bearing target cells is widely supported as the initiating event that culminate in severe disease 8 , 9 . (nature.com)
  • He has travelled extensively and written about Ebola virus disease epidemic after his visit to West Africa during the epidemic. (researchandmarkets.com)
  • His group led the study on Ebola virus disease survivors. (researchandmarkets.com)
  • In this review, we discuss the potential strengths and limitations of existing mouse models of dengue disease. (frontiersin.org)
  • Dengue fever is an acute febrile tropical disease. (sciencephoto.com)
  • Aethlon disclosed that it will incorporate data from the proposed dengue treatment study into a Humanitarian Use Device (HUD) submission, which provides an alternative FDA pathway for obtaining market approval for medical devices that address disease conditions that affect fewer than 4,000 individuals in the U.S. per year. (bio-medicine.org)
  • Dengue also represents a disease condition where efficacy treatment studies in the U.S. are not feasible. (bio-medicine.org)
  • The number of dengue cases has been increasing worldwide in part because of urbanization and in part due to the ability of the mosquito that carries the disease to adapt for survival in more temperate zones. (bio-medicine.org)
  • The extracted RNAs from dengue NS1 antigen ELISA-positive samples, archived at the APEX Referral Laboratory for Arboviruses (National Vector Borne Disease Control Programme, Manipal Centre for Virus Research), were used for the study. (go.jp)
  • Salvadoran health authorities confirmed Saturday that a dengue-like disease that has been spreading across the Caribbean has now appeared in the Central-American country. (medicalxpress.com)
  • Its transcribed polyprotein is cleaved by host- and virus-encoded peptidases into 10 proteins, some of which are of unknown function. (pnas.org)
  • Therefore, we have analyzed the ability of the 10 dengue virus-encoded proteins to antagonize the IFN response. (pnas.org)
  • The proteins are important because each contains a short amino acid sequence called a fusion peptide that the virus needs to attach itself to a potential host. (purdue.edu)
  • Is it the proteins that the virus produces, or some other things that the virus did? (biology-online.org)
  • The meaning of +sense RNA is: viruses with this kind of RNA can use their RNA as mRNA to translate some specific proteins they need. (biology-online.org)
  • Molecular cloning methods have led to a greater understanding of the structure of the RNA genome and definition of virus-specific structural and nonstructural proteins. (asm.org)
  • The binding efficiency is lower at 25°C. Two platelet surface proteins (called DC-SIGN and HSP) are dengue virus receptors through which the virus can bind. (blood.ca)
  • Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles," Journal of Infectious Diseases , vol. 189, no. 2, pp. 221-232, 2004. (hindawi.com)
  • Dr. Halstead said he got his first inkling of the phenomenon while doing extensive clinical studies of dengue virus patients in Thailand in the 1960s. (medindia.net)
  • NS1 is secreted from infected cells, counteracts antiviral immune responses, and contributes to the severe clinical manifestations of dengue. (eurekalert.org)
  • This is more sensitive than any other way of detecting Dengue, beating the clinical test by more than 100 fold," said Xing Wang, the corresponding author of the study, an assistant professor of chemistry and member of the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute at the time of the research. (newswise.com)
  • However, at best, they stop only half of the viruses from multiplying, which is not enough for clinical applications. (uni-mainz.de)
  • Hospital-based physicians were asked to complete a questionnaire that included demographic, clinical, and biologic information on each patient admitted with a diagnosis of dengue regardless of severity. (thefreelibrary.com)
  • They found that both strains seemed to block the transmission of dengue virus, and that the wMel strain was able to infect almost the entire test population in just a few generations. (innovations-report.com)
  • The risk of developing severe dengue fever, also known as dengue hemorrhagic fever, actually increases if you're infected a second, third or fourth time. (yahoo.com)
  • Dengue virus is carried by mosquitos. (drugs.com)
  • You may be at risk for dengue virus if you travel or live in an area with infected mosquitos. (drugs.com)
  • One moderately effective approach currently in use, he says, includes placing larvacide in water-storage containers, which stops the breeding of the mosquitos that spread the virus. (brandeis.edu)
  • Jul 13, 2020 · A multidisciplinary team from The University of Texas Medical Branch at Galveston has uncovered a new mechanism for designing antiviral drugs for dengue virus . (yahoo.com)
  • Sep 17, 2020 · The patient infected with dengue virus starts showing symptoms within 3 to 14 days. (yahoo.com)
  • This same study identified 47 strains of dengue virus. (wikipedia.org)
  • As many as 80% of people infected with dengue virus have no symptoms or mild fever whereas others develop more severe symptoms of dengue fever. (yahoo.com)
  • Signs and symptoms of dengue hemorrhagic fever or severe dengue - a life-threatening emergency - include: 1. (yahoo.com)
  • What are the signs and symptoms of dengue virus? (drugs.com)
  • The symptoms of dengue are sudden-onset fever, headache (located behind the eyes), muscle and joint pains, and a rash. (thaindian.com)
  • As of December 1, 2019, 180 dengue cases have been reported in California compared to 107 cases over the same time period in 2018. (constantcontact.com)
  • Eighteen dengue cases were reported in Orange County in 2019. (constantcontact.com)
  • 10 (53%) of Orange County's dengue cases in 2019 resulted from exposure in Mexico. (constantcontact.com)
  • Dengue hemorrhagic fever is characterized by a unique vascular leakage syndrome. (biomedsearch.com)
  • Living or traveling in tropical areas.Being in tropical and subtropical areas increases your risk of exposure to the virus that causes dengue fever. (yahoo.com)
  • Diego Alvarez , a 2009 Pew Latin American fellow and associate investigator at the National University of San Martin in Argentina, has received support from the Bunge and Born Foundation to develop diagnostic techniques for the virus that causes dengue fever. (pewtrusts.org)
  • That said, until the 2009-2010 southern Florida outbreak, the United States had remained basically dengue-free for more than half a century. (medicinenet.com)
  • A major outbreak developed in French Polynesia in 2013, with 19,000 suspected cases reported in a year, the first epidemic other than dengue fever to manifest in the area. (livescience.com)
  • This outbreak led to an increase in dengue surveillance as described ( 10 ). (cdc.gov)
  • We are now in the midst of a dengue outbreak. (jamaica-gleaner.com)
  • As part of the dengue treatment agreement, Qualtran has agreed to establish multiple treatment sites and recruit thought leaders from the dengue field to establish consensus treatment protocols in advance of the 2015 dengue outbreak season. (bio-medicine.org)
  • In recent decades, the outbreak of dengue has grown dramatically in the world. (sophia.org)
  • The research, published in 'PLOS Pathogens', notes that one of the strains of the virus, DENV2 has smooth spherical surface particles while growing at the carrier mosquito's physiological temperature of 29 0 Celsius. (indiatimes.com)
  • Dengue virus is one of the most prevalent mosquito-transmitted human pathogens. (eurekalert.org)
  • Dengue virus has increased dramatically within the last 20 years, becoming one of the worst mosquito-borne human pathogens with which tropical countries have to deal. (wikipedia.org)
  • The Bunge and Born funding will enable Alvarez to create a biochemical test to detect dengue molecules using immune cells. (pewtrusts.org)
  • North Carolina State University mathematical biologist Dr. Alun Lloyd is part of the Eliminate Dengue program, a research consortium that includes scientists from Australia and the United States. (innovations-report.com)
  • The work was conducted by an international team of scientists from the Eliminate Dengue program, and was published today in two papers in the journal Nature. (healthcanal.com)
  • In some patients with dengue hemorrhagic fever (DHF), vascular pathology can become severe, resulting in extensive microvascular permeability and plasma leakage into tissues and organs. (jci.org)
  • The research project, "Mechanisms of Competitive Displacement by Lineages of Mosquito-Borne Dengue Virus," was recognized by the university at a Scholarly Excellence Rally held Nov. 13. (infectioncontroltoday.com)
  • The scientists analyzed the genetic sequences of the defective and normal viruses to estimate how long the defective virus had been transmitting in the human population. (nsf.gov)
  • Singapore, June 24 (IANS) Scientists may have hit gold in their fight against dengue. (thaindian.com)
  • In a different experiment, the scientists isolated cytotoxic T cells from the blood of dengue-immune mice and infused them into normal mice, a procedure known as adoptive T-cell transfer. (eurasiareview.com)
  • Nevertheless, scientists' understanding of dengue virus may be simplistic, as rather than distinct antigenic groups, a continuum appears to exist. (wikipedia.org)