Dengue: An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.Dengue Virus: A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.Severe Dengue: A virulent form of dengue characterized by THROMBOCYTOPENIA and an increase in vascular permeability (grades I and II) and distinguished by a positive pain test (e.g., TOURNIQUET PAIN TEST). When accompanied by SHOCK (grades III and IV), it is called dengue shock syndrome.Dengue Vaccines: Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.Aedes: A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.Insect Vectors: Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Culicidae: A family of the order DIPTERA that comprises the mosquitoes. The larval stages are aquatic, and the adults can be recognized by the characteristic WINGS, ANIMAL venation, the scales along the wing veins, and the long proboscis. Many species are of particular medical importance.Thailand: Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.NicaraguaAntibody-Dependent Enhancement: Enhancement of viral infectivity caused by non-neutralizing antibodies. There are at least two mechanisms known to account for this: mediation by Fc receptors (RECEPTORS, FC) or by complement receptors (RECEPTORS, COMPLEMENT). Either the virus is complexed with antiviral IMMUNOGLOBULIN G and binds to Fc receptors, or virus is coated with antiviral IMMUNOGLOBULIN M and binds to complement receptors.Viral Nonstructural Proteins: Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.Disease Outbreaks: Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.VietnamFlavivirus: A genus of FLAVIVIRIDAE containing several subgroups and many species. Most are arboviruses transmitted by mosquitoes or ticks. The type species is YELLOW FEVER VIRUS.Mosquito Control: The reduction or regulation of the population of mosquitoes through chemical, biological, or other means.Serotyping: Process of determining and distinguishing species of bacteria or viruses based on antigens they share.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Puerto Rico: An island in the Greater Antilles in the West Indies. Its capital is San Juan. It is a self-governing commonwealth in union with the United States. It was discovered by Columbus in 1493 but no colonization was attempted until 1508. It belonged to Spain until ceded to the United States in 1898. It became a commonwealth with autonomy in internal affairs in 1952. Columbus named the island San Juan for St. John's Day, the Monday he arrived, and the bay Puerto Rico, rich harbor. The island became Puerto Rico officially in 1932. (From Webster's New Geographical Dictionary, 1988, p987 & Room, Brewer's Dictionary of Names, 1992, p436)Disease Vectors: Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.Travel: Aspects of health and disease related to travel.BrazilEnzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Americas: The general name for NORTH AMERICA; CENTRAL AMERICA; and SOUTH AMERICA unspecified or combined.Viral Envelope Proteins: Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.Sri LankaCuba: An island in the Greater Antilles in the West Indies, south of Florida. With the adjacent islands it forms the Republic of Cuba. Its capital is Havana. It was discovered by Columbus on his first voyage in 1492 and conquered by Spain in 1511. It has a varied history under Spain, Great Britain, and the United States but has been independent since 1902. The name Cuba is said to be an Indian name of unknown origin but the language that gave the name is extinct, so the etymology is a conjecture. (From Webster's New Geographical Dictionary, 1988, p302 & Room, Brewer's Dictionary of Names, 1992, p132)Rain: Water particles that fall from the ATMOSPHERE.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Polynesia: The collective name for the islands of the central Pacific Ocean, including the Austral Islands, Cook Islands, Easter Island, HAWAII; NEW ZEALAND; Phoenix Islands, PITCAIRN ISLAND; SAMOA; TONGA; Tuamotu Archipelago, Wake Island, and Wallis and Futuna Islands. Polynesians are of the Caucasoid race, but many are of mixed origin. Polynesia is from the Greek poly, many + nesos, island, with reference to the many islands in the group. (From Webster's New Geographical Dictionary, 1988, p966 & Room, Brewer's Dictionary of Names, 1992, p426)SingaporeTranslating: Conversion from one language to another language.Genetics, Behavioral: The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.IndiaPostural Balance: A POSTURE in which an ideal body mass distribution is achieved. Postural balance provides the body carriage stability and conditions for normal functions in stationary position or in movement, such as sitting, standing, or walking.Autophagy: The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Rhodnius: A genus of the subfamily TRIATOMINAE. Rhodnius prolixus is a vector for TRYPANOSOMA CRUZI.JapanCambodiaHoltzman Inkblot Test: Personality evaluation based on the scoring of several variables as a result of the subject's responses in perceiving 47 inkblot plates.Communicable DiseasesMusic: Sound that expresses emotion through rhythm, melody, and harmony.Chikungunya virus: A species of ALPHAVIRUS causing an acute dengue-like fever.Australia: The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

Scientists try new strategy to eradicate dengue fever.(1/2084)

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Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. (2/2084)

T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with <72 h of fever were studied. Plasma levels of 80-kDa soluble tumor necrosis factor receptors (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-gamma and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-alpha was detectable more often in DHF than in DF or OFIs (P<.05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.  (+info)

Variation in oral susceptibility to dengue type 2 virus of populations of Aedes aegypti from the islands of Tahiti and Moorea, French Polynesia. (3/2084)

Twenty three samples of Aedes aegypti populations from the islands of Tahiti and Moorea (French Polynesia) were tested for their oral susceptibility to dengue type 2 virus. The high infection rates obtained suggest that the artificial feeding protocol used was more efficient than those previously described. Statistical analysis of the results allowed us to define two distinct geographic areas on Tahiti with respect to the susceptibility of Ae. aegypti: the east coast, with homogeneous infection rates, and the west coast, with heterogeneous infection rates. No geographic differences could be demonstrated on Moorea. The possible mechanisms of this phenomenon are discussed in connection with recent findings on the variability of susceptibility of Ae. aegypti to insecticides.  (+info)

Serologic evidence for an epizootic dengue virus infecting toque macaques (Macaca sinica) at Polonnaruwa, Sri Lanka. (4/2084)

Dengue is one of the most rapidly emerging diseases in the tropics. Humans are the principal reservoir of dengue viruses. It is unclear if nonhuman primates also serve as a reservoir of human dengue viruses under certain conditions. In this study, a cross-sectional serologic survey was carried out to characterize the pattern of transmission of a recently identified dengue virus among toque macaques in Sri Lanka. The results indicated that an epizootic dengue virus was active among the macaques. A single epizootic had taken place between October 1986 and February 1987 during which 94% of the macaques within the 3 km2 study site were exposed to the virus. The epizootic was highly focal in nature because macaques living 5 km from the study population were not exposed to the virus. The transmission of dengue viruses among macaques in the wild may have important public health implications.  (+info)

Bacterial lipopolysaccharide inhibits dengue virus infection of primary human monocytes/macrophages by blockade of virus entry via a CD14-dependent mechanism. (5/2084)

Monocytes/macrophages (MO/Mphi) are the major target cells for both dengue virus (DV) and bacterial lipopolysaccharide (LPS), and the aim of this study was to define their interactions. We had found that LPS markedly suppressed DV infection of primary human MO/Mphi when it was added to cultures prior to or together with, but not after, viral adsorption. The inhibitory effect of LPS was direct and specific and was not mediated by LPS-induced secretion of cytokines and chemokines such as tumor necrosis factor alpha, interleukin-1beta (IL-1beta), IL-6, IL-8, IL-12, alpha interferon, MIP-1alpha, and RANTES. In fact, productive DV infection was not blocked but was just postponed by LPS, with a time lag equal to one viral replication cycle. Time course studies demonstrated that LPS was only effective in suppressing DV infection of MO/Mphi that had not been previously exposed to the virus. At various time points after viral adsorption, the level of unbound viruses that remained free in the culture supernatants of LPS-pretreated cultures was much higher than that of untreated controls. These observations suggest that the LPS-induced suppression of DV replication was at the level of virus attachment and/or entry. Blockade of the major LPS receptor, CD14, with monoclonal antibodies MY4 or MoS39 failed to inhibit DV infection but could totally abrogate the inhibitory effect of LPS. Moreover, human serum could significantly enhance the LPS-induced DV suppression in a CD14-dependent manner, indicating that the "binding" of LPS to CD14 was critical for the induction of virus inhibition. Taken together, our results suggest that LPS blocked DV entry into human MO/Mphi via its receptor CD14 and that a CD14-associated cell surface structure may be essential for the initiation of a DV infection.  (+info)

A deviation bar chart for detecting dengue outbreaks in Puerto Rico. (6/2084)

OBJECTIVES: A Centers for Disease Control and Prevention deviation bar chart (Statistical Software for Public Health Surveillance) and laboratory-based surveillance data were evaluated for their utility in detecting dengue outbreaks in Puerto Rico. METHODS: A significant increase in dengue incidence was defined as an excess of suspected cases of more than 2 SDs beyond the mean for all 4-week periods from April through June (the period of lowest seasonal incidence), 1989 through 1993. An outbreak was defined as a cumulative annual rate of reported dengue greater than 3 per 1000 population. RESULTS: Retrospective application of the system to 1994 data showed agreement with previous analyses. In 1995 and 1996, 36.4% and 27.3%, respectively, of municipalities with a significant increase in reports for 2 or more consecutive weeks before the first week of September had an outbreak, compared with 9.0% (in 1995, P = .042) and 6.0% (in 1996, P = .054) of towns without a significant increase. The system showed sensitivity near 40%, specificity near 89%, and accuracy in classifying municipalities near 84%. CONCLUSIONS: This method provides a statistically based, visually striking, specific, and timely signal for dengue control efforts.  (+info)

Effects of dengue fever during pregnancy in French Guiana. (7/2084)

To determine the effects of dengue fever (DF) during pregnancy, pregnant women presenting with a dengue-like syndrome at a hospital in Saint-Laurent du Maroni, French Guiana, from 1 January 1992 to 1 April 1998 were studied. The diagnosis of DF was made by serological tests, virus isolation on AP 61 mosquito cells, and/or reverse transcriptase polymerase chain reaction analysis. Twenty-two women had either probable or confirmed DF. Dengue virus serotype 2 was detected in four cases, and dengue virus serotype 1 was detected in one. Three fetuses died following the onset of the disease, and three cases of prematurity occurred. All infants appeared normal during physical examination, and no neonatal DF was diagnosed. In conclusion, DF in pregnant women did not cause any infant abnormality, but it may have been responsible for fetal death. The rate of fetal death associated with DF (13.6%) was much higher than the mean rate for the gynecology unit at the hospital (1.9%). However, these differences were not significant, and consequently these preliminary results need to be confirmed.  (+info)

Evaluation of the MRL diagnostics dengue fever virus IgM capture ELISA and the PanBio Rapid Immunochromatographic Test for diagnosis of dengue fever in Jamaica. (8/2084)

We evaluated two new commercial dengue diagnostic tests, the MRL Diagnostics Dengue Fever Virus IgM Capture ELISA and the PanBio Rapid Immunochromatographic Test, on serum samples collected during a dengue epidemic in Jamaica. The MRL ELISA method correctly identified 98% (78 of 80) of the samples as dengue positive, while the PanBio test identified 100% (80 of 80). Both tests were 100% (20 samples of 20) specific.  (+info)

  • At the root of the emergence of dengue as a major health problem are changes in human demography and behavior, leading to unchecked populations of and increased exposure to the principal domestic mosquito vector, Aedes aegypti. (pnas.org)
  • The Aedes aegypti mosquito is the main vector that transmits the viruses that cause dengue . (bingj.com)
  • Dengue is spread by several species of mosquito of the Aedes type, principally A. aegypti. (wikipedia.org)
  • Dengue is an arthropod-borne viral disease whose main vector is the mosquito Aedes aegypti . (scielo.sa.cr)
  • Dengue virus is transmitted by bite of mosquito vector known as Aedes aegypti . (org.pk)
  • 2000. 3.Nyamuk Aedes Aegypti maupun Aedes Albopictus merupakan vektor penularan virus dengue dari penderita kepada oranglainnya melalui gigitannya nyamuk Aedes Aegyeti merupakan vektor penting di daerah perkotaan (Viban) sedangkan didaerah pedesaan (rural) kedua nyamuk tersebut berperan dalam penularan.aedes polynesiensis dan beberapa spesies lain merupakan vektor yang kurang berperan. (scribd.com)
  • Here are 5 effective tips on how to keep mosquitoes away, and thus protect yourself and your family from diseases like Dengue, Malaria and Chikungunya. (ndtv.com)
  • Mosquitoes come to be infected with dengue after biting unwell people who have dengue virus in their blood. (healthandmedicines.com)
  • THURSDAY, Jan. 16, 2020 (HealthDay News) -- Mosquitoes that can't be infected by or spread dengue virus have been created by scientists. (nm.org)
  • The researchers genetically engineered the mosquitoes to be resistant to all four types of dengue, a mosquito-borne virus that's a significant global health threat. (nm.org)
  • This is the first time that mosquitoes have been genetically engineered to be resistant to all types of dengue, which could significantly improve control of the disease, the scientists added. (nm.org)
  • The team reported that it may be possible to create wild populations with such genetically modified mosquitoes that would be completely resistant to dengue. (nm.org)
  • The best way to prevent Dengue is to avoid bites by infected mosquitoes - particularly if you live in, or are traveling in, a tropical region. (indiahomehealthcare.com)
  • Dengue can be diagnosed clinically against predefined lists of signs and symptoms and by detection of dengue-specific antibodies, non-structural 1 antigen or viral RNA by reverse transcriptase-polymerase chain reaction. (tropmedres.ac)
  • Because there are no specific drugs approved for the treatment of dengue disease, care is limited to the management of symptoms. (medicaldialogues.in)
  • The time taken for Dengue to run its course in most people involves an incubation period of 10 -14 days, followed by a week of acute symptoms, and then a few days of recovery. (indiahomehealthcare.com)
  • This will allow your doctor to evaluate the possibility that your symptoms being caused by the dengue virus. (indiahomehealthcare.com)
  • What are the clinical features of Dengue shock syndrome? (org.pk)
  • Di setiap Negara penyakit DBD mempunyai manifestasi klinik yangberbeda.Dengue Shock Syndrome (SSD) / Dengue Syok Sindrom (DSS) adalah kasus deman berdarah dengue disertai denganmanifestasi kegagalan sirkulasi/ syok/ renjatan. (scribd.com)
  • Paris, France - August 13th, 2016 - Sanofi and its vaccines global business unit Sanofi Pasteur announced that 500,000 doses of Dengvaxia ® have been received in Paraná to support a large-scale public dengue immunization program initiated today in the State's 30 most highly endemic municipalities. (sanofi.com)
  • The strategic deployment of a safe and effective dengue vaccine offers the best hope of reducing dengue's burden, especially in highly endemic countries like Brazil. (sanofi.com)
  • Introduction of the dengue vaccine first in endemic countries like Brazil has always been Sanofi Pasteur's priority because this is where the vaccine can have the greatest impact on disease burden globally. (sanofi.com)
  • While there is no cure for dengue disease, today's approval is an important step toward helping to reduce the impact of this virus in endemic regions of the United States. (medicaldialogues.in)
  • The safety and effectiveness of the vaccine was determined in three randomized, placebo-controlled studies involving approximately 35,000 individuals in dengue-endemic areas, including Puerto Rico, Latin America and the Asia Pacific region. (medicaldialogues.in)
  • Thus, timely diagnosis and an accurate prognosis of severe dengue in the first few days of illness for clinical triage, treatment management, disease surveillance and research activities are vital and very helpful. (bl.uk)
  • Early and accurate diagnosis is important for guiding appropriate management and for disease surveillance to guide prompt dengue control interventions. (tropmedres.ac)
  • However, major uncertainties exist in dengue diagnosis and this has important implications for all three. (tropmedres.ac)
  • When a person falls ill from Dengue, it's initially difficult to make a precise diagnosis. (indiahomehealthcare.com)
  • The patient can also be treated with herbal domestic treatments inclusive of papaya leaves, kiwi, Tulsi Leaves and Black Pepper, Fenugreek Leaves and different meals items which have been verified to assist in the growth of platelet count, which get lower during dengue. (healthandmedicines.com)
  • While the incidences of many other infectious diseases have declined over the past decade, the number of cases and outbreaks of dengue virus have continued to increase. (laboratoryequipment.com)
  • Doctors are aware now that dengue is in the Mossman and Port Douglas area and they're reporting their suspicious cases to us. (wordpress.com)
  • Although dengue cases are rare in the continental U.S., the disease is regularly found in American Samoa, Puerto Rico, Guam, the U.S. Virgin Islands, as well as Latin America, Southeast Asia and the Pacific islands. (medicaldialogues.in)
  • He said three dengue cases were also reported from Balochistan province. (pakistannewsindex.com)
  • Younger children and people who have never suffered from Dengue before tend to have milder cases than older children and adults. (indiahomehealthcare.com)
  • Someone infected with one form of dengue will best come to be proof against that type. (healthandmedicines.com)
  • Islamabad, Sep 21 - Prime Minister Yousuf Raza Gilani has directed Pakistan International Airlines (PIA) to lift insecticides from India for the prevention of dengue. (topnews.in)
  • Virus-specified factors also influence the epidemiology of dengue. (pnas.org)
  • Dengue is fast emerging pandemic-prone viral disease in many parts of the world. (bingj.com)
  • Treatment of acute dengue is supportive and includes giving fluid either by mouth or intravenously for mild or moderate disease. (wikipedia.org)
  • For the public immunization program being launched today, we have used our extensive dengue surveillance data to ensure that we are targeting people at highest risk of disease. (sanofi.com)
  • Paraná has a good track record in vaccination coverage in general and successful implementation of this dengue immunization strategy could result in 74% reduction in disease burden in these highly impacted municipalities within 5 years, according to a dengue vaccine impact study published in the Brazilian Journal of Health Economics 1 ," Secretary Neto noted. (sanofi.com)
  • Dengue disease is the most common mosquito-borne viral disease in the world and global incidence has increased in recent decades," said Anna Abram, FDA deputy commissioner for policy, legislation, and international affairs. (medicaldialogues.in)
  • The vaccine was determined to be approximately 76 percent effective in preventing symptomatic, laboratory-confirmed dengue disease in individuals 9 through 16 years of age who previously had laboratory-confirmed dengue disease. (medicaldialogues.in)
  • They may not be immune to different types of dengue and might be at better threat of extreme disease if they contract another type. (healthandmedicines.com)
  • Dengue is a global public health emergency especially since there is no preventative vaccine or antiviral treatment for dengue disease. (gwu.edu)
  • Paraná State, home to 10 million people, has seen a steep 3-fold increase in both dengue incidence and deaths in recent years. (sanofi.com)
  • The safety, efficacy and public health value of the dengue vaccine has been independently endorsed by the World Health Organization (WHO) in position paper on Dengvaxia published on 29th July 2016 2 , which is consistent with the earlier positive recommendation on the dengue vaccine issued by the WHO's Strategic Advisory Group of Experts on Immunization last April. (sanofi.com)
  • We conducted three studies aiming to identify early markers of dengue, especially severe dengue and identify prognostic markers of severe dengue in Vietnamese children with clinically suspected dengue within the first few days of the illness. (bl.uk)
  • This thesis shows the results and also points out predictive models that may be used to prognosticate of severe dengue among patients with clinically suspected dengue who are admitted to hospital within the first few days of the illness. (bl.uk)