An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.
A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.
A virulent form of dengue characterized by THROMBOCYTOPENIA and an increase in vascular permeability (grades I and II) and distinguished by a positive pain test (e.g., TOURNIQUET PAIN TEST). When accompanied by SHOCK (grades III and IV), it is called dengue shock syndrome.
Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.
A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.
Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
Immunoglobulins produced in response to VIRAL ANTIGENS.
A family of the order DIPTERA that comprises the mosquitoes. The larval stages are aquatic, and the adults can be recognized by the characteristic WINGS, ANIMAL venation, the scales along the wing veins, and the long proboscis. Many species are of particular medical importance.
Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.
Enhancement of viral infectivity caused by non-neutralizing antibodies. There are at least two mechanisms known to account for this: mediation by Fc receptors (RECEPTORS, FC) or by complement receptors (RECEPTORS, COMPLEMENT). Either the virus is complexed with antiviral IMMUNOGLOBULIN G and binds to Fc receptors, or virus is coated with antiviral IMMUNOGLOBULIN M and binds to complement receptors.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
A genus of FLAVIVIRIDAE containing several subgroups and many species. Most are arboviruses transmitted by mosquitoes or ticks. The type species is YELLOW FEVER VIRUS.
The reduction or regulation of the population of mosquitoes through chemical, biological, or other means.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
An island in the Greater Antilles in the West Indies. Its capital is San Juan. It is a self-governing commonwealth in union with the United States. It was discovered by Columbus in 1493 but no colonization was attempted until 1508. It belonged to Spain until ceded to the United States in 1898. It became a commonwealth with autonomy in internal affairs in 1952. Columbus named the island San Juan for St. John's Day, the Monday he arrived, and the bay Puerto Rico, rich harbor. The island became Puerto Rico officially in 1932. (From Webster's New Geographical Dictionary, 1988, p987 & Room, Brewer's Dictionary of Names, 1992, p436)
Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.
Aspects of health and disease related to travel.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Ribonucleic acid that makes up the genetic material of viruses.
The general name for NORTH AMERICA; CENTRAL AMERICA; and SOUTH AMERICA unspecified or combined.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
An island in the Greater Antilles in the West Indies, south of Florida. With the adjacent islands it forms the Republic of Cuba. Its capital is Havana. It was discovered by Columbus on his first voyage in 1492 and conquered by Spain in 1511. It has a varied history under Spain, Great Britain, and the United States but has been independent since 1902. The name Cuba is said to be an Indian name of unknown origin but the language that gave the name is extinct, so the etymology is a conjecture. (From Webster's New Geographical Dictionary, 1988, p302 & Room, Brewer's Dictionary of Names, 1992, p132)
Water particles that fall from the ATMOSPHERE.
Substances elaborated by viruses that have antigenic activity.
The collective name for the islands of the central Pacific Ocean, including the Austral Islands, Cook Islands, Easter Island, HAWAII; NEW ZEALAND; Phoenix Islands, PITCAIRN ISLAND; SAMOA; TONGA; Tuamotu Archipelago, Wake Island, and Wallis and Futuna Islands. Polynesians are of the Caucasoid race, but many are of mixed origin. Polynesia is from the Greek poly, many + nesos, island, with reference to the many islands in the group. (From Webster's New Geographical Dictionary, 1988, p966 & Room, Brewer's Dictionary of Names, 1992, p426)
Conversion from one language to another language.
The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.
A POSTURE in which an ideal body mass distribution is achieved. Postural balance provides the body carriage stability and conditions for normal functions in stationary position or in movement, such as sitting, standing, or walking.
The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.
Established cell cultures that have the potential to propagate indefinitely.

Scientists try new strategy to eradicate dengue fever.(1/2084)

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Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. (2/2084)

T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with <72 h of fever were studied. Plasma levels of 80-kDa soluble tumor necrosis factor receptors (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-gamma and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-alpha was detectable more often in DHF than in DF or OFIs (P<.05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.  (+info)

Variation in oral susceptibility to dengue type 2 virus of populations of Aedes aegypti from the islands of Tahiti and Moorea, French Polynesia. (3/2084)

Twenty three samples of Aedes aegypti populations from the islands of Tahiti and Moorea (French Polynesia) were tested for their oral susceptibility to dengue type 2 virus. The high infection rates obtained suggest that the artificial feeding protocol used was more efficient than those previously described. Statistical analysis of the results allowed us to define two distinct geographic areas on Tahiti with respect to the susceptibility of Ae. aegypti: the east coast, with homogeneous infection rates, and the west coast, with heterogeneous infection rates. No geographic differences could be demonstrated on Moorea. The possible mechanisms of this phenomenon are discussed in connection with recent findings on the variability of susceptibility of Ae. aegypti to insecticides.  (+info)

Serologic evidence for an epizootic dengue virus infecting toque macaques (Macaca sinica) at Polonnaruwa, Sri Lanka. (4/2084)

Dengue is one of the most rapidly emerging diseases in the tropics. Humans are the principal reservoir of dengue viruses. It is unclear if nonhuman primates also serve as a reservoir of human dengue viruses under certain conditions. In this study, a cross-sectional serologic survey was carried out to characterize the pattern of transmission of a recently identified dengue virus among toque macaques in Sri Lanka. The results indicated that an epizootic dengue virus was active among the macaques. A single epizootic had taken place between October 1986 and February 1987 during which 94% of the macaques within the 3 km2 study site were exposed to the virus. The epizootic was highly focal in nature because macaques living 5 km from the study population were not exposed to the virus. The transmission of dengue viruses among macaques in the wild may have important public health implications.  (+info)

Bacterial lipopolysaccharide inhibits dengue virus infection of primary human monocytes/macrophages by blockade of virus entry via a CD14-dependent mechanism. (5/2084)

Monocytes/macrophages (MO/Mphi) are the major target cells for both dengue virus (DV) and bacterial lipopolysaccharide (LPS), and the aim of this study was to define their interactions. We had found that LPS markedly suppressed DV infection of primary human MO/Mphi when it was added to cultures prior to or together with, but not after, viral adsorption. The inhibitory effect of LPS was direct and specific and was not mediated by LPS-induced secretion of cytokines and chemokines such as tumor necrosis factor alpha, interleukin-1beta (IL-1beta), IL-6, IL-8, IL-12, alpha interferon, MIP-1alpha, and RANTES. In fact, productive DV infection was not blocked but was just postponed by LPS, with a time lag equal to one viral replication cycle. Time course studies demonstrated that LPS was only effective in suppressing DV infection of MO/Mphi that had not been previously exposed to the virus. At various time points after viral adsorption, the level of unbound viruses that remained free in the culture supernatants of LPS-pretreated cultures was much higher than that of untreated controls. These observations suggest that the LPS-induced suppression of DV replication was at the level of virus attachment and/or entry. Blockade of the major LPS receptor, CD14, with monoclonal antibodies MY4 or MoS39 failed to inhibit DV infection but could totally abrogate the inhibitory effect of LPS. Moreover, human serum could significantly enhance the LPS-induced DV suppression in a CD14-dependent manner, indicating that the "binding" of LPS to CD14 was critical for the induction of virus inhibition. Taken together, our results suggest that LPS blocked DV entry into human MO/Mphi via its receptor CD14 and that a CD14-associated cell surface structure may be essential for the initiation of a DV infection.  (+info)

A deviation bar chart for detecting dengue outbreaks in Puerto Rico. (6/2084)

OBJECTIVES: A Centers for Disease Control and Prevention deviation bar chart (Statistical Software for Public Health Surveillance) and laboratory-based surveillance data were evaluated for their utility in detecting dengue outbreaks in Puerto Rico. METHODS: A significant increase in dengue incidence was defined as an excess of suspected cases of more than 2 SDs beyond the mean for all 4-week periods from April through June (the period of lowest seasonal incidence), 1989 through 1993. An outbreak was defined as a cumulative annual rate of reported dengue greater than 3 per 1000 population. RESULTS: Retrospective application of the system to 1994 data showed agreement with previous analyses. In 1995 and 1996, 36.4% and 27.3%, respectively, of municipalities with a significant increase in reports for 2 or more consecutive weeks before the first week of September had an outbreak, compared with 9.0% (in 1995, P = .042) and 6.0% (in 1996, P = .054) of towns without a significant increase. The system showed sensitivity near 40%, specificity near 89%, and accuracy in classifying municipalities near 84%. CONCLUSIONS: This method provides a statistically based, visually striking, specific, and timely signal for dengue control efforts.  (+info)

Effects of dengue fever during pregnancy in French Guiana. (7/2084)

To determine the effects of dengue fever (DF) during pregnancy, pregnant women presenting with a dengue-like syndrome at a hospital in Saint-Laurent du Maroni, French Guiana, from 1 January 1992 to 1 April 1998 were studied. The diagnosis of DF was made by serological tests, virus isolation on AP 61 mosquito cells, and/or reverse transcriptase polymerase chain reaction analysis. Twenty-two women had either probable or confirmed DF. Dengue virus serotype 2 was detected in four cases, and dengue virus serotype 1 was detected in one. Three fetuses died following the onset of the disease, and three cases of prematurity occurred. All infants appeared normal during physical examination, and no neonatal DF was diagnosed. In conclusion, DF in pregnant women did not cause any infant abnormality, but it may have been responsible for fetal death. The rate of fetal death associated with DF (13.6%) was much higher than the mean rate for the gynecology unit at the hospital (1.9%). However, these differences were not significant, and consequently these preliminary results need to be confirmed.  (+info)

Evaluation of the MRL diagnostics dengue fever virus IgM capture ELISA and the PanBio Rapid Immunochromatographic Test for diagnosis of dengue fever in Jamaica. (8/2084)

We evaluated two new commercial dengue diagnostic tests, the MRL Diagnostics Dengue Fever Virus IgM Capture ELISA and the PanBio Rapid Immunochromatographic Test, on serum samples collected during a dengue epidemic in Jamaica. The MRL ELISA method correctly identified 98% (78 of 80) of the samples as dengue positive, while the PanBio test identified 100% (80 of 80). Both tests were 100% (20 samples of 20) specific.  (+info)

High prevalence of hepatitis B virus (HBV) infection in China offers a unique setting to examine HBVs influence on the presentation of dengue fever. In 398 patients admitted for suspected dengue fever, 89% (353/398) were positive for dengue IgM antibodies. Among dengue-infected patients, 8% (29/353) had chronic HBV co-infection. Only dengue virus serotype 1 was identified by virus isolation and reverse transcriptase-polymerase chain reaction assays. No case of dengue hemorrhagic fever/dengue shock syndrome was diagnosed. In addition to routine clinical tests, inter-leukin 2 (IL-2), IL-4, IL-6, IL-10, interferon γ (IFNγ), and tumor necrosis factor α (TNFα) levels were measured in the sera of 95% (334/353) of dengue-infected subjects as well as controls. Surprisingly, HBV/dengue co-infected patients made less IL-6 (P < 0.05) and TNFα (P < 0.05) than patients with only dengue infection. Similar levels of IL-4, IL-10, and IFNγ were found in both groups. Thus, HBV co-infection seems to alter the
Schon mal was von dem gefährlichen Virus Denguefieber gehört? Mindestens genauso ansteckend ist der treibende Cumbia-Future-Sound des Duos Dengue Dengue Dengue! aus der peruanischen Millionenmetropole Lima. Mit wobbeligen Bässen ausgeliehen aus dem Dubstep, futuristischen Sounds seziert aus dem Techno und psychedelischen Sounds inspiriert aus der 70er Jahre Cumbia-Chicha hebt Dengue Dengue Dengue! den Cumbia-Digital Sound auf ein neues Level. Auf den Live-Shows von Dengue Dengue Dengue! bekommt man das Gefühl mit einem UFO direkt auf dem peruanischen Inkatempel Machu-Pichu zu landen - inmitten eines futuristischen Technoraves mit Ausblick über den amazonischen Urwald. Dengue Dengue Dengue! ist ein junges Duo bestehend aus Felipe Salmon und Rafael Pereira. Beide sind auch Teil des Colectivo Auxiliar, ein peruanisches Sound-Laboratorium. Der Name Dengue Dengue Dengue! entspringt einer Enrique Lynch Platte, der darauf einen Rhythmus spielt, der sich Dengue nennt. Das Projekt überzeugt von ...
Death because of fever is increasing day by day. Dengue fever is the main type of fever which leads to this increased mortality rate It is important to prevent the disease. if the disease caused have to be treated properly. Proper medicine and the rest is the main defensive way to prevent dengue fever dengue fever is also called break bone fever. Dengue fever is a viral disease the dengue virus which is spread by mosquito is the main reason behind dengue fever.. If once dengue fever host it will make antibodies over the body for the lifetime the first time of dengue fever is known as Type 1 dengue fever is Dengue fever caused more than one time then then it would be type 2 dengue fever.. ...
Author Summary Dengue disease is a tropical and subtropical mosquito-borne viral illness and is a major health concern in the Philippines. To determine the dengue disease burden in the Philippines and identify gaps and future research needs, we conducted a literature analysis and review to describe the epidemiology of dengue disease. We used well-defined methods to search and identify relevant research conducted between 2000 and 2011. This long-term review highlights an increase in the reported incidence of dengue disease in the Philippines. The rising incidence of dengue disease may be related to a growing population, increasing urbanization, improvements in surveillance, and the limited success of vector control measures. Gaps in the epidemiological information available in the Philippines during the period 2000-2011 include comprehensive national and regional data that describe the proportion of severe dengue disease, including hospitalizations and mortality, and incidence data per 100,000 population
Dengue fever is a severe health problem in tropical areas, with two-thirds of the world population at risk of infection (24). Four virus serotypes and even more quasispecies can be differentiated both in the transmitting insect (A. aegypti) and in the blood of patients with acute dengue fever (26). During recent decades Europe has been free of dengue infections, but as a result of increasing tourism every year several thousand tourists return to European countries with acute dengue fever.. In the second half of 1998 we diagnosed 172 dengue patients. All patients were European tourists, most of whom had experienced a disease with high fever and headache for several days. Usually early serum samples were taken 4 to 8 days after the onset of symptoms. Therefore, early serum samples without dengue virus antibodies at all or with either IgG or IgM antibodies were obtained from only 25 patients (15%). In 20 early samples viral RNA could be demonstrated by TaqMan PCR, in one case even in the presence ...
Scanning electron microscopy of the four larval instars of the Dengue fever vector Aedes aegypti (Diptera: Culicidae). Stefan Schaper1 & Francisco Hernández-Chavarría2. 1 Institute for Zoology, Tierärztliche Hochschule Hannover, Germany and Universidad Nacional, Heredia, Costa Rica.. 2 Centro de Investigación en Estructuras Microscópicas and Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica; [email protected] Received 09-IV-2003. Corrected 16-IX-2005. Accepted 23-III-2006.. Abstract: Aedes aegypti is the main insect vector of Dengue fever and dengue hemorrhagic fever/dengue shock syndrome and represents the only vulnerable element in the control of this disease. Therefore, the identification and quantification of this mosquito is an important task; however, the majority of taxonomic keys are based on the 4th larval instar. For that reason, this study describes the four larval instars of A. aegypti using scanning electron microscopy. Morphological changes ...
Last week the World Health Organization (WHO) reported that dengue is the worlds fastest-spreading tropical disease. As reported by Reuters, dengue is a threat that is present in more than 125 countries.. The WHO estimates that 50 and 100 million dengue infections occur worldwide every year, but acknowledges that this is likely a conservative figure. The CDC estimates that about 2.5 billion people, or 40% of the worlds population, live in areas where there is a risk of dengue transmission. The areas in which dengue is endemic include Asia, Africa and Latin America, but it is present on all continents.. Dengue fever is caused by any one of four dengue virus serotypes and is transmitted by the Aedes aegypti and Aedes albopictus mosquito species. Infection with one serotype does not provide immunity against other dengue serotypes, and multiple infections put people at risk for dengue hemorrhagic fever and dengue shock syndrome. Dengue symptoms typically begin four to seven days following the ...
BACKGROUND: Dengue virus is endemic in tropical and sub-tropical resource-poor countries. Dengue illness can range from a nonspecific febrile illness to a severe disease, Dengue Shock Syndrome (DSS), in which patients develop circulatory failure. Earlier diagnosis of severe dengue illnesses would have a substantial impact on the allocation of health resources in endemic countries. METHODS AND FINDINGS: We compared clinical laboratory findings collected within 72 hours of fever onset from a prospective cohort children presenting to one of two hospitals (one urban and one rural) in Thailand. Classification and regression tree analysis was used to develop diagnostic algorithms using different categories of dengue disease severity to distinguish between patients at elevated risk of developing a severe dengue illness and those at low risk. A diagnostic algorithm using WBC count, percent monocytes, platelet count, and hematocrit achieved 97% sensitivity to identify patients who went on to develop DSS while
Dengue fever is a serious threat for public health and induces various inflammatory cytokines and mediators, including galectins and glycoproteins. Diverse immune responses and immunological pathways are induced in different phases of dengue fever progression. However, the status of serum galectins and glycoproteins is not fully determined. The aim of this study was to investigate the serum concentration and potential interaction of soluble galectin-1, galectin-3, galectin-9, galectin-3 binding protein (galectin-3BP), glycoprotein 130 (gp130), and E-, L-, and P-selectin in patients with dengue fever in acute febrile phase. In this study, 317 febrile patients (187 dengue patients, 150 non-dengue patients that included 48 patients with bacterial infection and 102 patients with other febrile illness) who presented to the emergency department and 20 healthy controls were enrolled. Our results showed the levels of galectin-9 and galectin-3BP were significantly higher in dengue patients than those in healthy
TY - JOUR. T1 - Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities. AU - Chuang, Yung Chun. AU - Lin, Yee Shin. AU - Liu, Hsiao Sheng. AU - Wang, Jen Reng. AU - Yeh, Trai Ming. PY - 2013. Y1 - 2013. N2 - Dengue virus (DENV) infection may result in severe life-threatening Dengue haemorrhagic fever (DHF). The mechanisms causing haemorrhage in those with DHF are unclear. In this study, we demonstrated that antibodies against human thrombin were increased in the sera of Dengue patients but not in that of patients infected with other viruses. To further characterise the properties of these antibodies, affinity-purified anti-thrombin antibodies (ATAs) were collected from Dengue patient sera by thrombin and protein A/L affinity columns. Most of the ATAs belonged to the IgG class and recognized DENV nonstructural protein 1 (NS1). In addition, we found that dengue patient ATAs also cross-reacted with human plasminogen (Plg). Functional studies in ...
Currently, several assays can diagnose acute dengue infection. However, none of these assays can predict the severity of the disease. Biomarkers that predicts the likelihood that a dengue patient will develop a severe form of the disease could permit more efficient patient triage and allows better supportive care for the individual in need, especially during dengue outbreaks. We measured 20 plasma markers i.e. IFN-γ, IL-10, granzyme-B, CX3CL1, IP-10, RANTES, CXCL8, CXCL6, VCAM, ICAM, VEGF, HGF, sCD25, IL-18, LBP, sCD14, sCD163, MIF, MCP-1 and MIP-1β in 141 dengue patients in over 230 specimens and correlate the levels of these plasma markers with the development of dengue without warning signs (DWS−), dengue with warning signs (DWS+) and severe dengue (SD). Our results show that the elevation of plasma levels of IL-18 at both febrile and defervescence phase was significantly associated with DWS+ and SD; whilst increase of sCD14 and LBP at febrile phase were associated with severity of dengue disease
Abstract. Half a million patients are hospitalized with severe dengue every year, many of whom would die without timely, appropriate clinical intervention. The majority of dengue cases are uncomplicated; however, 2-5% progress to severe dengue. Severe dengue cases have been reported with increasing frequency over the last 30 years. To discover biomarkers for severe dengue, we used surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to analyze dengue virus positive serum samples from the acute phase of infection. Using this method, 16 proteins were identified as candidate biomarkers for severe dengue. From these 16 biomarkers, three candidates were selected for confirmation by enzyme-linked immunosorbent assay and Western blot: vitronectin (Vtn, 55.1 kDa), hemopexin (Hx, 52.4 kDa), and serotransferrin (Tf, 79.2 kDa). Vitronectin, Hx, and Tf best differentiated between dengue and severe dengue.
Geographic expansion of dengue incidence has drawn a global interest to identify the influential factors that instigate the spread of this disease. The objective of this study was to find the environmental factors linked to dengue incidence in a dengue epidemic area of Nepal by negative binomial models using climatic factors from 2010 to 2017. Minimum temperature at lag 2 months, maximum temperature and relative humidity without lag period significantly affected dengue incidence. Rainfall was not associated with dengue incidence in Chitwan district of Nepal. The incident rate ratio (IRR) of dengue case rise by more than 1% for every unit increase in minimum temperature at lag 2 months, maximum temperature and relative humidity, but decrease by .759% for maximum temperature at lag 3 months. Considering the effect of minimum temperature of previous months on dengue incidence, the vector control and dengue management program should be implemented at least 2 months ahead of dengue outbreak season.
TY - JOUR. T1 - Tri-phasic fever in dengue fever. AU - Pradeepa, H. D.. AU - Rao, Sathish B.. AU - Ganaraj, B.. AU - Bhat, Gopalakrishna. AU - Chakrapani, M.. PY - 2018/4/1. Y1 - 2018/4/1. N2 - Dengue fever is an acute febrile illness with a duration of 2-12 days. Our observational study observed the 24-h continuous tympanic temperature pattern of 15 patients with dengue fever and compared this with 26 others with fever due to a non-dengue aetiology. A tri-phasic fever pattern was seen among two-thirds of dengue fever patients, but in only one with an inflammatory disease. One-third of dengue fever patients exhibited a single peak temperature. Continuous temperature monitoring and temperature pattern analysis in clinical settings can aid in the early differentiation of dengue fever from non-dengue aetiology.. AB - Dengue fever is an acute febrile illness with a duration of 2-12 days. Our observational study observed the 24-h continuous tympanic temperature pattern of 15 patients with dengue ...
|i|Introduction.|/i| Dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), and expanded dengue syndrome (EDS) with atypical presentations, thus posing a diagnostic dilemma. Unless we are aware of these presentations, diagnosis as well as early initiation of treatment becomes difficult. We studied the various clinical presentations of dengue infection during an outbreak of disease in 2015.|i| Materials and Methods|/i|. A total of 115 confirmed cases of dengue infection from Department of Medicine of Deen Dayal Upadhyay Hospital, New Delhi, were enrolled in this observational study.|i| Results.|/i| The common signs and symptoms of dengue infection were fever, headache, body ache, backache, retro-orbital pain, bleeding manifestations, and rash in 100%, 87%, 86%, 58%, 41%, 21%, and 21%, respectively. Nonspecific or warning
The capital region of Colombo has recorded 7369 cases to date alone.. Local media reports that the death toll due to dengue is 40 in Sri Lanka to date.. The World Health Organization says dengue is transmitted by the bite of a mosquito infected with one of the four dengue virus serotypes. It is a febrile illness that affects infants, young children and adults with symptoms appearing 3-14 days after the infective bite.. Dengue is not transmitted directly from person-to-person and symptoms range from mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash.. Severe dengue (also known as dengue hemorrhagic fever) is characterized by fever, abdominal pain, persistent vomiting, bleeding and breathing difficulty and is a potentially lethal complication, affecting mainly children. Early clinical diagnosis and careful clinical management by trained physicians and nurses increase survival of patients.. Related: ...
Dengue is a viral infection spread by mosquitoes. It is endemic in Malaysia, as it is in most tropical countries. Worldwide, dengue is also the fastest spreading mosquito-borne viral diseases. Symptoms can range from a mild fever to severe dengue fever with bleeding, accumulation of fluid in the lungs and abdomen, shock and death. Dengue doesnt choose who it affects, anybody can get dengue, whether young or old, woman or man. Health clinic staff and doctors would usually advise patients to drink more water if they are suspected to have dengue fever. Whether this is beneficial or not has not been well studied so far. If oral (by mouth) fluid intake is beneficial, the next question is how to improve the delivery of this advice to dengue patients who come to the primary health care clinics. A simple fluid chart has been designed that patients suspected of having dengue fever should complete every day for as long as they are being followed up by their doctor for the condition. The patient with ...
Dengue fever and dengue hemorrhagic fever (DHF) are acute febrile diseases, found in the tropics and Africa, and caused by four closely related virus serotypes of the genus Flavivirus, family Flaviviridae.The geographical spread is similar to malaria, but unlike malaria, dengue is often found in urban areas of tropical nations, including Singapore, Taiwan, Indonesia, Philippines, India and Brazil. Each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. Dengue is transmitted to humans by the Aedes aegypti (rarely Aedes albopictus) mosquito, which feeds during the day.. Dengue (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), of the genus Flavivirus. Infection with one of these serotypes provides immunity to only that serotype for life, so persons living in a dengue-endemic area can have more than ...
In the 20th century dengue fever became one of the leading causes of morbidity and mortality throughout the tropics. The dengue virus is an arbovirus transmitted by Aedes mosquitoes. There are four distinct serotypes of dengue arbovirus (DENV-1, 2, 3, 4). According to the World Health Organization, a person infected by one of the dengue viruses can develop symptoms ranging from the classical self-limiting form characterized by high temperature, headache, myalgia, and arthralgia to the severe, potentially fatal, form known as dengue shock syndrome. For over 40 years the main explanation for the pathogenesis of dengue has been based on the antibody-dependent enhancement (ADE) concept stating that enhancing antibodies acquired during a primary infection increase the number of infected cells, and thus the level of viremia, during secondary infection. However the severity of dengue is not limited to dengue shock syndrome and there are many cases that do not conform to the ADE concept. A meta-analysis could
The Instituto Nacional de Salud reports that through August 29, Colombia has seen 647 accumulated cases of Chagas disease. The vast majority of cases are considered chronic (91%), while the remainder are acute infections.. Boyacá state has reported the most chronic Chagas cases accounting for 18% of the total.. Chikungunya. After reporting a little over 100,000 autochthonous, or indigenous chikungunya cases in 2014, Colombian health authorities have reported 331,366 in 2015 through August.. Virus circulation in Colombia has been demonstrated in 35 territorial entities. To date, 48 chikungunya-related deaths have been reported, with six reported as a co-infection with dengue fever.. Dengue fever. The number of dengue fever cases in Colombia during the first eight months of 2015 is down about 10% compared to the same period last year. To date, 61,451 dengue cases have been reported, including 788 cases of severe dengue. In 2014, 68,884 dengue cases were reported.. 81% of dengue cases came from 11 ...
Background Dengue pathogen (DENV) contamination may trigger serious hemorrhagic disease in human beings. when KU812 cells had been transfected with the autophagy-inhibiting Atg4BC74A mutant. Findings/Significance Our outcomes demonstrate a significant induction of autophagy in antibody-enhanced DENV contamination of pre-basophil-like KU812 and immature mast cell-like HMC-1 cells. Also, autophagy takes on an essential part in DENV contamination and duplication in these cells. Provided the importance of ADE and FcR-bearing cells such as monocytes, basophil/mast and macrophages cells in dengue disease, the outcomes offer information into dengue pathogenesis and restorative means of control. Intro Dengue disease is usually a serious wellness issue in exotic or subtropical areas of the globe [1], [2]. Dengue computer virus (DENV) contamination can trigger 1255517-77-1 supplier moderate dengue fever to serious life-threatening dengue hemorrhagic fever and dengue surprise symptoms [3]C[5]. Many systems ...
The Philippines and Thailand share a common history when it comes to dengue because it was in these two countries where the dengue hemorrhagic fever, a lethal complication of dengue fever, was first reported and identified in the 1950s.. Fifty-eight years later, dengue fever has become a major international public health concern considering that majority of those affected are children ages between one and 10 years old.. Hospitalized. Though dengue fever is usually not a fatal disease, young patients are more likely to be hospitalized especially if they develop high fever, severe headache, strain in muscles and rashes.. If left unmanaged, dengue fever could kill up to 20 percent of those infected as the patient develops life-threatening conditions like bleeding, low levels of blood platelets and blood plasma leakage (dengue hemorrhagic fever) and circulatory failure (dengue shock syndrome).. According to Dr. Lyndon Lee Suy, program manager of the Department of Healths Emerging and Reemerging ...
TY - JOUR. T1 - Re-assess Vector Indices Threshold as an Early Warning Tool for Predicting Dengue Epidemic in a Dengue Non-endemic Country. AU - Chang, Fong Shue. AU - Tseng, Yao Ting. AU - Hsu, Pi Shan. AU - Chen, Chaur Dong. AU - Lian, Ie Bin. AU - Chao, Day Yu. PY - 2015/9/14. Y1 - 2015/9/14. N2 - Background: Despite dengue dynamics being driven by complex interactions between human hosts, mosquito vectors and viruses that are influenced by climate factors, an operational model that will enable health authorities to anticipate the outbreak risk in a dengue non-endemic area has not been developed. The objectives of this study were to evaluate the temporal relationship between meteorological variables, entomological surveillance indices and confirmed dengue cases; and to establish the threshold for entomological surveillance indices including three mosquito larval indices [Breteau (BI), Container (CI) and House indices (HI)] and one adult index (AI) as an early warning tool for dengue epidemic. ...
Dengue is fast emerging pandemic-prone viral disease in many parts of the world. Dengue flourishes in urban poor areas, suburbs and the countryside but also affects more affluent neighbourhoods in tropical and subtropical countries.. Dengue is a mosquito-borne viral infection causing a severe flu-like illness and, sometimes causing a potentially lethal complication called severe dengue. The incidence of dengue has increased 30-fold over the last 50 years. Up to 50-100 million infections are now estimated to occur annually in over 100 endemic countries, putting almost half of the worlds population at risk.. Severe dengue (previously known as dengue haemorrhagic fever) was first recognized in the 1950s during dengue epidemics in the Philippines and Thailand. Today it affects Asian and Latin American countries and has become a leading cause of hospitalization and death among children and adults in these regions.. The full life cycle of dengue fever virus involves the role of mosquito as a ...
Dengue has a broad spectrum of clinical symptoms, ranging from asymptomatic infection, undifferentiated fever and dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). DHF and DSS are the most severe forms of the disease, as they involve bleeding and hypovolemic shock and may lead to death if they are not diagnosed early and treated correctly. Every year, about 36 million cases of DF, of which about 2.1 million cases are DHF/DSS resulting in 21,000 deaths among children and young adults, are reported. Dengue not only has negative effects on public health worldwide but also poses significant economic burden. However, no licensed vaccines or (specific) anti-viral therapies for prevention or treatment of dengue are available. Thus, timely diagnosis and an accurate prognosis of severe dengue in the first few days of illness for clinical triage, treatment management, disease surveillance and research activities are vital and very helpful. We conducted three studies ...
The Brazilian Ministry of Health has reported 746,000 registered cases of Dengue fever and 229 confirmed deaths since January 2015 [1,3]. This marks a 234% increase in Dengue cases and a 45% increase in Dengue deaths since the previous year [3]. Although nine states are currently experiencing an outbreak of Dengue, more than half of these cases occurred in São Paulo, which also happens to be Brazils most populous state [1]. To date, São Paulo has had three times as many Dengue cases as there were reported in 2014 [1].. Dengue Fever. Dengue fever is a viral disease transmitted to humans through the bite of an infected female mosquito [1-5]. Dengue can be found in tropical and sub-tropical climates across the globe, primarily in urban and semi-urban areas [5]. This places about half of the worlds population at risk [5]. The incubation period for Dengue fever is 4 to 10 days [5]. Symptoms last about 2 to 7 days and include: high fever, severe headache, pain behind the eyes, muscle and joint ...
For countries considering vaccination as part of their dengue control program, a pre-vaccination screening strategy would be the preferred option, in which only dengue-seropositive persons are vaccinated.. Conventional serological testing for dengue virus IgG (e.g. dengue IgG ELISA) could be used to identify persons who have had previous dengue infections. Sensitivity and specificity of dengue IgG ELISA should be assessed in a local context, and will depend on the prevalence of other flaviviruses, and past use of flavivirus vaccines (such as Japanese encephalitis and yellow fever vaccines). Currently available rapid diagnostic tests - despite their lower sensitivity and specificity to detect past dengue infection compared with conventional dengue IgG ELISA - could be considered in high transmission settings until better tests are available. In settings with high dengue transmission (high numbers of seropositives), a test with lower specificity might be acceptable.. The pre-test probability of ...
REFERENCES. 1. Simmons CP, Farrar JJ, Nguyen V, Wills B. Dengue. N Engl J Med. 2012; 366(15): 1423-32. [ Links ] 2. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013; 496(7446): 504-7. [ Links ] 3. Hernandez-Avila JE, Rodriguez MH, Santos-Luna R, Sanchez-Castaneda V, Roman-Perez S, Rios-Salgado VH, et al. Nation-wide, web-based, geographic information system for the integrated surveillance and control of dengue fever in Mexico. PLoS One. 2013; 8(8): e70231. [ Links ] 4. Dirección General de Epidemiología. Lineamientos para la vigilancia epidemiológica de dengue por laboratorio. Disponible en: Disponible en: https://goo.gl/qDH4k7 . Consultado en enero de 2017. [ Links ] 5. Hernández-Suárez CM, Mendoza-Cano O. Empirical evidence of the effect of school gathering on the dynamics of dengue epidemics. Global health action. 2016; 9: 28026. [ Links ] 6. World Health Organization. Dengue Haemorrhagic Fever: Diagnosis, ...
Karachi: Three more dengue viral fever cases were reported on Thursday, increasing the number of confirmed cases this year to 141, said Focal Person for Dengue Surveillance Cell Dr Shakeel Aamir Mullick.. Dr Mullick said a total of 152 dengue fever cases had so far been reported in 2014, out of which 141 were reported in Karachi, two in Hyderabad and six in the rest of Sindh. He said three dengue cases were also reported from Balochistan province.. He said that a dengue patient had expired in city this year so far. He said three new dengue fever cases were reported (03OPD) 27th March 2014.. ...
Dengue virus (DENV) is a flavivirus of worldwide importance, with approximately 4 billion people across 128 countries at risk of infection, and up to 390 million infections and 96 million clinically apparent cases estimated annually. Previous in vitro studies have shown that lipids and lipoproteins play a role in modifying virus infectivity. However, the relationship between development of severe dengue and total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), respectively, is unclear. We analyzed data from 789 laboratory-confirmed dengue cases and 447 other febrile illnesses (OFI) in a prospective pediatric hospital-based study in Managua, Nicaragua between August 2005 and January 2013, using three different classifications of dengue severity: World Health Organization (WHO) 1997, WHO 2009, and standardized intervention categories. Total serum cholesterol and LDL-C levels decreased over the course of illness and were generally lower ...
Author Summary Without effective drugs or a vaccine, vector control remains the only method of controlling dengue fever outbreaks in Singapore. Based on our previous findings on the effects of weather on dengue cases and optimal timing for issuing dengue early warning in Singapore, the purpose of this study was to develop a dengue forecasting model that would provide early warning of a dengue outbreak several months in advance to allow sufficient time for effective control to be implemented. We constructed a statistical model using weekly mean temperature and rainfall. This involved 1) identifying the optimal lag period for forecasting dengue cases; 2) developing the model that described past dengue distribution patterns; 3) performing sensitivity tests to analyze whether the selected model could detect actual outbreaks. Finally, we used the selected model to forecast dengue cases from 2011-2012 week16 using weather data alone. Our model forecasted for a period of 16 weeks with high sensitivity in
AFUCOSYLATED MATERNAL ANTI-DENGUE IGGS ARE A BIOMARKER FOR SUSCEPTIBILITY TO SEVERE DENGUE DISEASE IN INFANTS. Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have developed a method for determining infant susceptibility to severe dengue disease through measurement of maternal anti-dengue IgG. Mortality rates in severe dengue disease can exceed 20% when patients are not hospitalized but can be reduced to less than 1% with inpatient care. Therefore, the identification of biomarkers for increased susceptibility to dengue disease could dramatically reduce mortality rates by enabling early hospitalization of those at highest risk for disease progression. Here, the inventors conducted a global analysis of anti-dengue IgGs from mothers of infants with known disease severity during primary dengue infections in order to identify features of maternal IgGs that indicate dengue disease risk in infants.. Stage of Research The glycosylation state of the IgG Fc domain plays a role in ...
Infection by flaviviruses such as dengue virus serotypes (DENV 1-4), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBE), yellow fever virus (YFV) and West Nile virus (WNV) impact millions of lives and cause tens of thousands of mortalities each year. Dengue is a global public health emergency especially since there is no preventative vaccine or antiviral treatment for dengue disease. Dengue: Methods and Protocols offers the increasing number of dengue researchers a one-stop protocol book with techniques compiled from the leading laboratories working on dengue. Chapters cover topics such as dengue virus isolation from clinical samples, quantification of human antibodies against the virus, assays to quantify the virus particles, the widely used mouse model to study dengue pathogenesis, vaccine and antiviral efficacies. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and
Recent dengue outbreaks in the Caribbean and Central and South America and the presence of competent mosquito vectors increase the likelihood of future autochthonous transmission in Florida. During April 1997 to March 1998, a laboratory-based active surveillance program detected 18 cases of dengue involving all four dengue serotypes. All patients reported recent travel to countries with indigenous dengue transmission. These results demonstrate that dengue infections are imported into Florida at a much higher rate than reflected by previous passive surveillance; therefore, the risk for local dengue transmission may be increasing.
We all hear about the rising cases of dengue, chikungunya, malaria due to the breeding of mosquitoes in the monsoon season. According to the civic bodies, the National Capital Region has reported 284 new dengue cases in the last ten days, taking the total to 771. There were around 50,000 dengue cases which were reported last year.. India has observed a 14 times increase in the number of dengue cases reported between 2007 and 2013 (as per National Vector Borne Disease Control Programme) with symptoms that require hospitalisation for its treatment. Such rise in dengue cases has resulted in an increase in the health insurance claims in past years as per the insurers.. What is dengue?. Dengue or break-bone fever is a mosquito-borne viral disease which is mainly found in the tropical and subtropical countries. This disease is caused by one of the four related dengue viruses and is an infectious disease. It is a life-threatening disease, and there is no vaccination or drug available to cure the ...
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Abstract: Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations. We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 infection and confirmed clinical diagnosis of either severe dengue, known as dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in Recife, Pernambuco, Brazil. An association analysis was performed using Fishers association test, with odds ratios (ORs) calculated using conditional maximum likelihood estimates. HLA-B*44 (P=0.047, OR = 2.025, 95% CI = 0.97-4.24) was found to be associated with increased susceptibility to DHF in response to DENV-3 infection. In addition, HLA-B*07 (P=0.048, OR = 0.501, one-sided 95% CI = 0-0.99) and HLA-DR*13 (P=0.028, OR = 0.511, one-sided 95% CI = 0-0.91) were found to be associated with resistance to secondary dengue ...
Dengue is the worlds most common arboviral infection, with almost 4 billion people estimated to be living at risk of dengue infection. A recently introduced vaccine is currently recommended only for seropositive individuals in a restricted age range determined by transmission intensity. With no effective dengue vaccine for the general population or any antiviral therapy, dengue control continues to rely heavily on vector control measures. Early and accurate diagnosis is important for guiding appropriate management and for disease surveillance to guide prompt dengue control interventions. However, major uncertainties exist in dengue diagnosis and this has important implications for all three. Dengue can be diagnosed clinically against predefined lists of signs and symptoms and by detection of dengue-specific antibodies, non-structural 1 antigen or viral RNA by reverse transcriptase-polymerase chain reaction. All of these methods have their limitations. This review aims to describe and quantify the
BACKGROUND Dengue infection is a major vector-borne disease. The classical sings and symptoms of this infection include high fever, violent headache, chill and rash. However, there are a number of atypical forms of dengue infection including those presented with liver dysfunction. However, there are only a few reports concerning the liver dysfunction among the patients with dengue infections. METHODS Here, the author presents a summative study on the liver dysfunction and its clinical correlation among Thai patients in the previous studies. A literature review on the prospective studies concerning liver function and dengue infection in Thailand was performed. RESULTS According to this study, there are 4 reports included covering 191 Thai pediatric patients with dengue infection. The overall rate of liver dysfunction among 191 subjects is 34.6 % (66/191). The rate of liver dysfunction among the patients without shock (36/120) is not significant different from those with shock. The rate of liver
Dengue (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), of the genus Flavivirus. Infection with one of these serotypes provides immunity to only that serotype for life, so persons living in a dengue-endemic area can have more than one dengue infection during their lifetime. DF and DHF are primarily diseases of tropical and sub tropical areas, and the four different dengue serotypes are maintained in a cycle that involves humans and the Aedes mosquito. However, Aedes aegypti, a domestic, day-biting mosquito that prefers to feed on humans, is the most common Aedes species. Infections produce a spectrum of clinical illness ranging from a nonspecific viral syndrome to severe and fatal hemorrhagic disease. Important risk factors for DHF include the strain of the infecting virus, as well as the age, and especially the prior dengue infection history of the patient ...
The Senate today approved on third and final reading a bill seeking to appropriate a P1.16 billion supplemental budget for the Department of Health (DOH) this year to fund medical assistance programs for dengue patients in the country.. House Bill No. 7449, sponsored by Senator Loren Legarda, chairperson of the Senate Committee on Finance and co-sponsored by Senator Richard Gordon, was approved with 18 affirmative votes, zero negative vote and no abstention.. According to Legarda, the supplemental budget of P1,161,710,000 for the DOH would be used exclusively to fund medical assistance programs for dengue patients, including those who are confined or are outpatients.. The above allocation will also be used to provide medical assistance for hospitalization, out-patient care services, procurement of supplies and medicine, she said.. The supplemental budget, Legarda said, would provide help and allay the fears of the almost 900,000 individuals, both children and adults, who were administered ...
The U.S. Food and Drug Administration has granted approval to first vaccine approved vaccine for Dengue prevention -Dengvaxia.The vaccine prevents against dengue disease caused by all dengue virus serotypes (1, 2, 3 and 4) in people ages 9 through 16 who have laboratory-confirmed previous dengue infection and who live in endemic areas.
Dengue is not transmitted directly from person-to-person. Instead, it is transmitted by the bite of a mosquito infected with one of the four dengue virus serotypes. It is a febrile illness that affects infants, young children and adults. Symptoms range from mild fever to incapacitating high fever with rash, severe headache, pain behind the eyes, as well as muscle and joint pain. The disease is also known as breakbone fever due to the severe pain it can cause. Severe dengue (also known as dengue hemorrhagic fever) affects mainly children, and is characterized by fever, abdominal pain, persistent vomiting, bleeding and breathing difficulty - it is potentially deadly.. The WHO estimates that about half of the worlds population is now at risk. However, at this time, there is no licensed vaccine or any specific medicine to treat dengue. Fortunately, there is hope. Several vaccines are in the final steps of development, with the one produced by the French pharmaceutical company Sanofi Pasteur ...
The other thing Im concerned with is that many of us delegate our household chores to our hired help, and dengue prevention tasks like the 5-Step Mozzie Wipeout may be one of the chores that can be overlooked at times. Im quite keen to make sure that this is done myself even if we have help at home.. For us, dengue prevention is a serious business, as Ive reminded everyone over the years, our now 7-year-old son had to have two blood transfusions at 8 weeks old due to dengue fever. So hes going to go around our apartment and do the Mozzie Wipeout with me regularly as well.. Its no joke - there have been more than 5,900 reported cases of dengue since the beginning of the year. So get on it now, and make the Mozzie Wipeout part of your household routine.. ...
Islamabad, Sep 21 - Prime Minister Yousuf Raza Gilani has directed Pakistan International Airlines (PIA) to lift insecticides from India for the prevention of dengue.. The insecticide has to be got from Mumbai.. There has been a rise in dengue cases in Pakistan, with Punjab province reporting over 6,000 dengue patients. About 35 people have died due to dengue.. The insecticides were purchased by the Punjab government.. The PIA was reluctant to airlift the insecticide due to rules which prohibit the transportation of the material of this nature, the Associated Press of Pakistan reported.. The prime ministers instructions led to a waiver due to the dengue epidemic.. Gilani had said that the country needs to develop a national coordination mechanism for controlling epidemics like dengue.. Dengue fever is caused by a virus transmitted by the aedes aegypti mosquito. Symptoms include fever, headache, muscle and joint pains and a skin rash similar to measles. Patients suffer from bleeding and low ...
The World Health Organization estimates that dengue virus causes more than 50 million cases of dengue fever a year. Dengue virus infection is the leading cause of hospitalization and death in children of most tropical Asian countries. There are four different serotypes of dengue virus. Most cases of dengue hemorrhagic fever/dengue shock syndrome are caused by secondary infection with a dengue serotype different from the first serotype the individual was infected with. A vaccine that would be effective in preventing infection by multiple dengue serotypes is desirable. The purpose of this study is to determine the safety of and immune response to two different dengue virus vaccines in individuals who have been previously vaccinated against a different serotype.. This study will last at least 42 days. Participants will be recruited from a database of previous dengue vaccine recipients and will be stratified by the type of vaccine previously received. Participants assigned to Cohort 1 and Cohort 2 ...
It is known that antibodies to dengue viruses at subneutralizing concentrations enhance dengue virus infection of Fc gamma R+ cells. This phenomenon called antibody-dependent enhancement (ADE) occurs when virus-antibody complexes bind to the Fc gamma R via the Fc portion of the Ig. It has been hypothesized that ADE may be responsible for the pathogenesis of the severe manifestations of dengue virus infection including dengue hemorrhagic fever/dengue shock syndrome. To further analyze the mechanisms of ADE, we prepared bispecific antibodies by chemically cross-linking antidengue virus antibodies to antibodies specific for Fc gamma RI or Fc gamma RII and the non-Fc R molecules beta2 microglobulin, CD15 or CD33 and examined whether these bispecific antibodies could enhance infection. Bispecific antibodies targeting dengue virus to Fc gamma RI or Fc gamma RII enhanced dengue virus infection, consistent with previous reports using conventional antibodies. Furthermore, bispecific antibodies targeting ...
Dengue virus is a human pathogen that causes dengue fever, which can either resolve after mild fever or lead to severe dengue hemorrhagic fever/dengue shock syndrome. The role of dengue virus levels in the blood and the kinetics of infection and immune response that results in severe dengue disease in humans is not well characterized. In this study, we analyzed 97 children with varying degrees of dengue disease, and we show that the dengue virus quantity in blood does not show any significant association with severe disease. However, most severe dengue patients had lower levels of interferons and Th1 cytokines and increased levels of secreted factors such as IL-6, IL-8 and IL-10 that could potentially cause leakage in blood capillaries. Our results indicate that monocytes, which are infected with dengue virus in patients, could possibly play a major role in dengue pathogenesis. Furthermore, using computational analysis we identified association of some of the secreted factors with severe disease ...
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The dengue viruses are spread by mosquitoes and infect up to 390 million individuals annually in sub-tropical and tropical regions of the world. Dengue disease has emerged as the most important arthropod-borne viral disease of humans. Dengue virus infection generally results in dengue fever, a debilitating but self limited febrile disease. However, complications may arise, leading to the potentially fatal dengue haemorrhagic fever/dengue shock syndromes (DHF/DSS). Despite intensive research over recent years, the pathogenesis of DHF/DSS is still poorly understood and there is neither a safe and effective vaccine nor suitable anti-viral treatments to control dengue disease.. Current investigations in the laboratory focus on understanding the role of specific viral proteins in the virus lifecycle and the role they play in perturbing host cellular processes. Our studies use a dengue virus reverse genetic system, in combination with structural, biochemical and high throughput transcriptomic and ...
TY - JOUR. T1 - Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome. AU - Tsai, Jih Jin. AU - Chokephaibulkit, Kulkanya. AU - Chen, Po Chih. AU - Liu, Li Teh. AU - Hsiao, Hui Mien. AU - Lo, Yu Chih. AU - Perng, Guey Chuen. PY - 2013/12/5. Y1 - 2013/12/5. N2 - Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making it an escalating global health problem of today. Dengue presents with spectrum of clinical manifestations, ranging from asymptomatic, undifferentiated mild fever, dengue fever (DF), to dengue hemorrhagic fever (DHF) with or without shock (DSS), a life-threatening illness characterized by plasma leakage due to increased vascular permeability. Currently, there are no antiviral modalities or vaccines available to treat and prevent dengue. Supportive care with close monitoring is the standard clinical ...
Dengue viruses cause dengue fever and the more severe condition, dengue hemorrhagic fever/shock syndrome. Dengue viruses are common in most tropical and subtropical regions of the world and infection with dengue viruses is the leading cause of hospitalization and death in children in many tropical Asian countries. For these reasons, the World Health Organization (WHO) has made the development of a dengue virus vaccine a top priority. This study will evaluate the safety and immunogenicity of two doses of a live attenuated, tetravalent dengue virus vaccine called TetraVax-DV in healthy adults (18-50 years old) who have previously been infected with a dengue virus or other flavivirus or have previously received a flavivirus vaccine. Two different formulations of the TetraVax-DV vaccine will be evaluated.. Participants will be randomly assigned to receive one of two admixtures of the TetraVax-DV vaccine or a placebo. At a baseline study visit (Day 0), participants will undergo a medical history ...
In the absence of truly effective and sustainable vector control measures, a dengue vaccine is urgently needed. While dengue vaccines have been under development since the 1940s, due to the limited appreciation of global dengue disease burden and of the potential markets for dengue vaccines, the industrys interest languished throughout much of the 20th century.. In recent years, however, the development of dengue vaccines has accelerated dramatically. Sanofi Pasteurs Dengvaxia® became the first dengue vaccine to be licensed for use in 2015. Today, several other vaccines are in various stages of advanced development, with clinical trials currently underway.. Vaccine development for dengue is particularly challenging because dengue fever is caused by any of four related, but distinct, virus serotypes (DENV-1-4). While infection by one virus provides lifelong immunity against that serotype, it provides only partial and transient immunity against the other three. This means that an effective ...
BACKGROUND: Sri Lanka has been affected by epidemics of dengue infections for many decades and the incidence and severity of dengue infections have been rising each year. Therefore, we investigated the age stratified seroprevalence of dengue infections in order to facilitate future dengue vaccine strategies. In addition, since the symptomatic dengue infections have increased during the past few decades, we also investigated the possible association with Japanese Encephalitis Virus (JEV) antibody seropositivity with symptomatic dengue in a community cohort in Sri Lanka. METHODS: 1689 healthy individuals who were attending a primary health care facility were recruited. Dengue and JEV antibody status was determined in all individuals and JEV vaccination status was recorded. RESULTS: 1152/1689 (68.2%) individuals were seropositive for dengue and only 133/1152 (11.5%) of them had been hospitalized to due to dengue. A significant and positive correlation was observed for dengue antibody seropositivity and age
The NEJM article reported results from a new pooled efficacy analysis of individuals 9 years of age and older at vaccination from the two Phase III studies of Sanofi Pasteurs dengue vaccine. The new analysis documented that the vaccine protects two-thirds of these individuals (66%) against dengue, providing even greater protection against two clinically relevant manifestations of dengue, namely severe dengue (93%) and prevention of hospitalizations due to dengue (80%) that account for the greatest human and economic burden of dengue in endemic countries. In addition, the dengue vaccine candidate protected volunteers 9 years of age and older who were previously exposed to dengue (82%), as well as those who were naïve to dengue (52.5%) prior to vaccination ...
Dengue fever, a viral disease transmitted by the mosquito Aedes aegypti, can spread rapidly in explosive epidemics. In Puerto Rico, dengue is a seasonal disease estimated to be responsible for more than 1,000 hospitalizations annually. Dengue transmission is influenced by the behavior of Aedes aegypti, movement and distribution of humans, and virus development within the mosquito. The role of each of these factors is poorly understood, in part, because of the absence of studies on the spatialtemporal patterns of dengue cases. Furthermore, recent failures of mosquito control programs designed to reduce dengue transmission indicate that long standing assumptions about the dispersal of dengue virus by mosquitoes are incorrect. The spatial and temporal distribution of dengue cases reported to the Centers for Disease Controls dengue surveillance system during a 1991-92 outbreak in Florida, Puerto Rico, and a normal transmission season (May 1994 - June 1995) in Ponce, Puerto Rico, were studied using ...
Medical information, Dengue hemorrhagic fever. Definition of Dengue hemorrhagic fever, symptoms of Dengue hemorrhagic fever, treatment of Dengue hemorrhagic fever, and prevention of Dengue hemorrhagic fever. Exams and Tests Dengue hemorrhagic fever.
Research recently published in PLoS Medicine challenges the dogma of the antibody-dependent enhancement model (ADE) for the development of dengue hemorrhagic fever (DHF). Dengue virus infection usually causes a severe flu like illness, although symptoms may be mild in young children. DHF, however, is a severe and sometimes fatal complication of dengue virus infection that affects about half a million people every year. DHF patients usually fall into two groups; children and adults who become infected with a second dengue virus serotype after an initial primary dengue virus infection with a different serotype, and infants with primary dengue virus infections born to mothers who have some dengue virus immunity. The current model for development of DHF in infants around 6 months old is that anti-dengue virus antibodies transferred from a dengue-immune mother to her child somehow enhance dengue virus infection, resulting in more severe symptoms (the antibody-dependent enhancement model). A ...
Via Radio New Zealand: Dengue fever cases in Vanuatu now over 300. Vanuatus Ministry of Health says the number of confirmed dengue fever cases in the country has climbed to 313. At the end of last month the number of...
Dengue IgG one step dengue antigen rapid rapid test kit IgM Ab Rapid Test Kit One Step Diagnosis Blood Testing. The Dengue IgG one step dengue antigen rapid rapid test kitIgM Ab Rapid Test Cassette (Whole Blood one step dengue antigen rapid rapid test kitSerum one step dengue antigen rapid rapid test kitPlasma) is a qualitative membrane-based immunoassay for the detection of Dengue antibodies in whole blood, serum, or plasma. The Dengue IgG one step dengue antigen rapid rapid test kitIgM Ab Rapid Test Cassette (Whole Blood one step dengue antigen rapid rapid test kit Serum one step dengue antigen rapid rapid test kit Plasma) is a qualitative membrane-based immunoassay for the ...
Dengue virus infection is one of the most common mosquito-borne illnesses worldwide, with nearly four billion people living in at risk areas throughout the world. Reported cases to World Health Organization continue to rise exponentially with an estimated 50 - 100 million symptomatic cases, mostly in Asia. Most clinical cases present with a self-limited viral illness, but some experience life-threatening severe disease. Four serotypes of dengue virus exist; infection by one serotype confers long lasting homotypic immunity, but does not confer heterotypic immunity to another serotype. Subsequent infection from a different dengue serotype can lead to the development of severe dengue. Antibody-dependent enhancement of dengue virus infection has been implicated in the development of severe disease. There have been various efforts to develop vaccines against dengue, including subunit vaccines that use only the viral envelope glycoprotein, or portions thereof. Those efforts are hampered by the ...
TY - JOUR. T1 - The exploration of risk factors of concurrent bacteraemia in patients critically ill with severe dengue. AU - Chen, Chin Ming. AU - Chan, Khee Siang. AU - Cheng, Kuo Chen. AU - Chou, Willy. AU - Chao, Hui Chun. AU - Yeh, Chiu Yin. AU - Yu, Wen Liang. PY - 2016/12/1. Y1 - 2016/12/1. N2 - We investigated the clinical features of intensive care unit (ICU) patients with concomitant severe dengue infection and bacteraemia to identify risk factors for this comorbidity. The records of all ICU dengue patients admitted during the period of 31 July-30 November 2015 were reviewed. Patients with concurrent bacteremia (positive bacterial blood culture within 72 h of ICU admission) were identified. ICU admission was required for 142 patients, of which 22 (15.5%) had concurrent bacteraemia. Species of the genus Streptococcus was the most common pathogens, followed by Escherichia coli then species of the genus Staphylococcus. Patients with a severe dengue infection and bacteraemia had higher ...
The new WHO 2009 classification of dengue divides suspected cases into three categories: dengue without warning signs, dengue with warning signs and severe dengue. We evaluated the WHO 2009 classification vs physicians subjective clinical diagnosis (gestalt clinical impression) in a large cohort of patients presenting to a tertiary care center in southern Sri Lanka hospitalized with acute febrile illness. We confirmed acute dengue in 388 patients (305 adults ≥ 18 years and 83 children), including 103 primary and 245 secondary cases, of 976 patients prospectively enrolled with AFI. At presentation, both adults and children with acute dengue were more likely than those with other AFI to have leukopenia and thrombocytopenia. Additionally, adults were more likely than those with other AFI to have joint pain, higher temperatures, and absence of crackles on examination whereas children with dengue were more likely than others to have sore throat, fatigue, oliguria, and elevated hematocrit and ...
Dengue virus infection in humans can lead to a wide range of clinical manifestations, from mild fever to potentially fatal dengue shock syndrome. The incidence of dengue fever is on the rise in tropical countries. Due to the increasing incidence of dengue fever worldwide, atypical manifestations of the disease are increasingly reported. In this article we report a patient with dengue haemorrhagic fever who presented with reversible splenial lesion syndrome. A 24-year-old Sri Lankan man who presented with fever and confusion was eventually diagnosed to have reversible splenial lesion syndrome based on brain imaging. Clinical, serological and haematological parameters confirmed a diagnosis of dengue haemorrhagic fever. His presentation, assessment, and management are described in this case report. Reversible splenial lesion syndrome is a condition which is radiologically characterized by reversible lesion in the splenium of the corpus callosum. It is associated with infectious and non-infectious
This research advances the fundamental understanding of how dengue virus replicates. Although platelets lack a nucleus, these tiny blood cells contain all the machinery needed to synthesize proteins and replicate RNA. The findings of this study are unprecedented and show that dengue hijacks blood platelets, commandeering the cells machinery to produce viral proteins and replicate its own genome. How this links to thrombocytopenia normally seen with dengue virus is still unclear. The possibility that viral antigens are exposed directly on platelets is now being considered for the first time. Dengue virus replicating in red blood cell units was a surprising finding as these cells do not have replication machinery.. The involvement of other residual cells found in red blood cell units is suspected. Blood donor systems worldwide are vulnerable to dengue virus. There have been five documented cases of dengue transmission by blood transfusion, all occurring in regions where dengue is present or ...
TY - JOUR. T1 - Prevalence of dengue virus serotypes in the 2017 outbreak in Peshawar, KP, Pakistan. AU - Khan, Najeeb Ullah. AU - Danish, Lubna. AU - Khan, Hydayat Ullah. AU - Shah, Maryam. AU - Ismail, Muhammad. AU - Ali, Ijaz. AU - Petruzziello, Arnolfo. AU - Sabatino, Rocco. AU - Guzzo, Annunziata. AU - Botti, Gerardo. AU - Iqbal, Aqib. N1 - © 2020 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.. PY - 2020/9. Y1 - 2020/9. N2 - BACKGROUND: Dengue is a viral disease, transmitted by infected Aedes aegypti and Aedes albopictus female mosquitoes. Worldwide, 96 million infections were estimated in 2010. The dengue virus comprises four distinct serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) which belong to the genus Flavivirus. Determining the serotypes during dengue outbreaks is crucial for its effective management in terms of diagnostics improvement and polyvalent vaccine development. The aim of the present study is to determine the prevalence rate of ...
Although endothelial cells have been speculated to be a target in the pathogenesis of dengue hemorrhagic fever (DHF), there has been little evidence linking dengue virus infection to any alteration in endothelial cell function. In this study, we show that human umbilical vein endothelial cells become activated when exposed to culture fluids from dengue virus-infected peripheral blood monocytes. Maximum activation was achieved with culture fluids from monocytes in which virus infection was enhanced by the addition of dengue virus-immune serum, thus correlating with epidemiological evidence that prior immunity to dengue virus is a major risk factor for DHF. Activation was strongest for endothelial cell expression of VCAM-1 and ICAM-1. In contrast, activation of endothelial cell E-selectin expression appeared to be more transient, as indicated by its detection at 3 h, but not at 16 h, of treatment. Treatment of monocyte culture fluids with anti-tumor necrosis factor alpha (TNF-alpha) antibody ...
Author(s): Forshey, Brett M; Reiner, Robert C; Olkowski, Sandra; Morrison, Amy C; Espinoza, Angelica; Long, Kanya C; Vilcarromero, Stalin; Casanova, Wilma; Wearing, Helen J; Halsey, Eric S; Kochel, Tadeusz J; Scott, Thomas W; Stoddard, Steven T | Abstract: BackgroundNearly half of the worlds population is at risk for dengue, yet no licensed vaccine or anti-viral drug is currently available. Dengue is caused by any of four dengue virus serotypes (DENV-1 through DENV-4), and infection by a DENV serotype is assumed to provide life-long protection against re-infection by that serotype. We investigated the validity of this fundamental assumption during a large dengue epidemic caused by DENV-2 in Iquitos, Peru, in 2010-2011, 15 years after the first outbreak of DENV-2 in the region.Methodology/principal findingsWe estimated the age-dependent prevalence of serotype-specific DENV antibodies from longitudinal cohort studies conducted between 1993 and 2010. During the 2010-2011 epidemic, active dengue cases were
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In this study the prevalence of dengue virus IgG antibodies among first-generation Surinamese immigrants was 81%. Although seroprevalence studies among Surinamese inhabitants are not available, this is comparable with the results from seroprevalence studies among populations in Latin America [10-13]. It seems like immigration to a non dengue endemic country causes little difference in dengue seroprevalence between the Surinamese immigrants and the majority of populations living in dengue-endemic areas of the Americas and the Caribbean get infected with the dengue virus.. As expected, the seroprevalence of previous DENV infection in our study was positively related to the duration participants had lived in Suriname before immigration. This is in line with studies performed among persons living in dengue-endemic countries in Latin America where they found higher seroprevalence rates of DENV antibodies by increasing age, which can be seen as a marker for duration of exposure [13, 14].. A limitation ...
Dengue is endemic in the U.S. Virgin Islands, but no outbreaks have been reported since 2005 (1). In November 2012, a school nurse in St. Croix reported suspected dengue in 27 (7%) of 369 students and staff members to the Virgin Islands Department of Health (VIDOH) and the CDC Dengue Branch in Puerto Rico. Four of 12 patient specimens sent to the CDC Dengue Branch for diagnostic testing were confirmed as dengue. Although VIDOH had observed an increase in passive dengue reporting, reliable baseline case counts were unavailable for comparison. An investigation was begun to determine the incidence of recent dengue virus (DENV) infection in schools and islandwide. A seroincidence study was conducted at six schools in addition to the index school, using a stratified two-stage cluster sampling methodology. Of 320 participants, 40 (20%) of 203 students and 20 (17%) of 118 staff members were immunoglobulin M (IgM) anti-DENV positive, indicating DENV infection within the preceding 3 months. Four students ...
Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted in any clinical and in vivo studies. The aim of this study is to investigate the effect of freeze-dried CPLJ treatment on NS1 and viremia levels of dengue fever mouse model. The dengue infection in mouse model was established by inoculation of non-mouse adapted New Guinea C strain dengue virus (DEN-2) in AG129 mice. The freeze-dried CPLJ compounds were identified by Ultra-High Performance Liquid Chromatography High Resolution Accurate Mass Spectrometry analysis. The infected AG129 mice were orally treated with 500 mg/kg/day and 1000 mg/kg/day of freeze-dried CPLJ, starting on day 1 post infection for 3 consecutive days. The blood samples were collected from submandibular vein for plasma NS1 assay and
Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted in any clinical and in vivo studies. The aim of this study is to investigate the effect of freeze-dried CPLJ treatment on NS1 and viremia levels of dengue fever mouse model. The dengue infection in mouse model was established by inoculation of non-mouse adapted New Guinea C strain dengue virus (DEN-2) in AG129 mice. The freeze-dried CPLJ compounds were identified by Ultra-High Performance Liquid Chromatography High Resolution Accurate Mass Spectrometry analysis. The infected AG129 mice were orally treated with 500 mg/kg/day and 1000 mg/kg/day of freeze-dried CPLJ, starting on day 1 post infection for 3 consecutive days. The blood samples were collected from submandibular vein for plasma NS1 assay and
Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted in any clinical and in vivo studies. The aim of this study is to investigate the effect of freeze-dried CPLJ treatment on NS1 and viremia levels of dengue fever mouse model. The dengue infection in mouse model was established by inoculation of non-mouse adapted New Guinea C strain dengue virus (DEN-2) in AG129 mice. The freeze-dried CPLJ compounds were identified by Ultra-High Performance Liquid Chromatography High Resolution Accurate Mass Spectrometry analysis. The infected AG129 mice were orally treated with 500 mg/kg/day and 1000 mg/kg/day of freeze-dried CPLJ, starting on day 1 post infection for 3 consecutive days. The blood samples were collected from submandibular vein for plasma NS1 assay and
The immunopathology of severe dengue remains incompletely understood. Most patients who develop severe dengue have had prior infection with one or more dengue serotypes. When an individual is infected... more
The immunopathology of severe dengue remains incompletely understood. Most patients who develop severe dengue have had prior infection with one or more dengue serotypes. When an individual is infected... more
SINGAPORE - Dengvaxia, a dengue vaccine available here since March, could prove detrimental to people who have never been infected by dengue. Sanofi, which produces the vaccine, sent out an alert saying: For those not previously infected by dengue virus, the analysis found that in the longer term, more cases of severe disease could occur following vaccination upon a subsequent dengue infection. The French pharmaceutical giant said it will ask the health authorities in countries where it has been approved for use, such as in Singapore, to update their information on the vaccine. A spokesman for the Health Sciences Authority (HSA) said on Thursday (Nov 30) that it is working with Sanofi Pasteur to strengthen the package insert to include the warning of an increased risk of hospitalisation for dengue and clinically severe dengue in vaccinated individuals not previously in... Full article: http://www.straitstimes.com/singapore/health/dengue-vacci... ...
Dengue fever is prevalent in the world; in recent years, several outbreaks occurred in West Africa. It affects pregnant women. We aimed to assess the consequences of dengue fever on pregnant women and their fetuses during dengue epidemic in Burkina Faso. We conducted a cross-sectional study from November 1, 2015 to January 31, 2017 in 15 public and private health facilities in Ouagadougou, using secondary data. Immunochromatographic rapid test Duo detecting specific antibodies, immunoglobin M/G and /or dengue non structural antigen1 virus was used to diagnose dengue cases. Out of 399 (48%) women registered during the study period, 25 (6%) were pregnant. The average age of pregnant women was 30 years, with 18 and 45 years as extremes. The main symptoms were fever (92%) and headache (92%). Nine patients (36%) had severe dengue characterized by bleeding (16%), neurological symptoms (16%) and acute respiratory distress (8%). Eight (32%) of the 25 women had early miscarriage and 8 (32%) women gave birth to
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Anti-dengue virus immunoglobulin M kits were evaluated. Test sensitivities were 21%-99% and specificities were 77%-98% compared with reference ELISAs. dengue igg igm dengue rapid test kit price lower °C 2-30 2-8 2-8 2-8 2-8 Rapid diagnostic tests Test name Dengue duo cassette Hapalyse dengue-M PA kit Dengucheck WB SD dengue IgG/IgM Company, location Panbio Diagnostics Pentax, Tokyo dengue igg igm dengue rapid test kit price ...
Dengue fever[edit]. Dengue fever is an infectious disease caused by dengue viruses known to be in the tropical regions.[36] It ... Dengue fever used to be considered a tropical disease, but climate change is causing dengue fever to spread. Dengue fever is ... If someone is infected with one type of dengue virus, he or she will have permanent immunity to that type of dengue virus, but ... "Dengue and Severe Dengue, Fact Sheet". Media Centre. World Health Organization. 2012.. ...
Diseases such as dengue fever, hepatitis, tuberculosis, malaria and pneumonia continue to plague India due to increased ... "Dengue". Source: Centers for Disease Control and Prevention US. Retrieved 2011-09-20. Goldwert, Lindsay. "'Totally drug- ...
"First FDA-approved vaccine for the prevention of dengue disease in endemic regions". U.S. Food and Drug Administration (FDA) ( ...
"Dengue and dengue hemorrhagic fever". Clinical Microbiology Reviews. 11 (3): 480-96. doi:10.1128/CMR.11.3.480. PMC 88892. PMID ... "The Incubation Periods of Dengue Viruses". PLOS ONE. 7 (11): e50972. Bibcode:2012PLoSO...750972C. doi:10.1371/journal.pone. ...
Dengue fever 2011-08-05 Diffuse panbronchiolitis 2012-01-15 DNA 2007-02-13 ...
Dengue fever Dengue viruses (DEN-1, DEN-2, DEN-3 and DEN-4) - Flaviviruses ...
Dengue and chikungunya fever[edit]. Main article: Dengue fever. There are 50-100 million dengue virus infections annually.[25] ... "Dengue Control". Retrieved 12 March 2014.. *^ a b c Pialoux, Gilles; Gaüzère, Bernard-Alex; Jauréguiberry, Stéphane; Strobel, ... No treatment for either dengue or severe dengue exists beyond palliative care.[25] The symptoms are high fever and flu-like ... resulting in a potentially fatal disease called severe dengue.[25] Dengue fever is caused by a flavivirus, and is spread mostly ...
Ross TM (March 2010). "Dengue virus". Clinics in Laboratory Medicine. 30 (1): 149-60. doi:10.1016/j.cll.2009.10.007. PMID ...
Singaporean dengue (2005). *Indian dengue (2006). *Chikungunya outbreaks (2006). *Pakistani dengue (2006) ...
Singaporean dengue (2005). *Indian dengue (2006). *Chikungunya outbreaks (2006). *Pakistani dengue (2006) ...
Singaporean dengue (2005). *Indian dengue (2006). *Chikungunya outbreaks (2006). *Pakistani dengue (2006) ...
Singaporean dengue (2005). *Indian dengue (2006). *Chikungunya outbreaks (2006). *Pakistani dengue (2006) ...
Singaporean dengue (2005). *Indian dengue (2006). *Chikungunya outbreaks (2006). *Pakistani dengue (2006) ...
Singaporean dengue (2005). *Indian dengue (2006). *Chikungunya outbreaks (2006). *Pakistani dengue (2006) ...
"Ethanopium" (Dengue Fever) - 4:38 *Instrumental, composed by Mulatu Astatke. *"Unnatural Habitat" (The Greenhornes) - 2:08 ...
Farrar's research interests are in infectious diseases[8] such as tuberculosis,[22] dengue fever,[23][24][25][26] typhoid fever ... Julie Steenhuysen and Ben Hirschler (December 13, 2017), Did Sanofi, WHO ignore warning signals on dengue vaccine? Reuters. ... In addition to his role at the Wellcome Trust, Farrar co-chaired the World Health Organization's working group on dengue ... SAGE Working Group on Dengue Vaccines and Vaccination (March 2015 to August 2016) World Health Organization. ...
Carod-Artal FJ, Wichmann O, Farrar J, Gascón J (September 2013). "Neurological complications of dengue virus infection". The ... The tropical viral infection dengue fever and Zika virus have also been associated with episodes of GBS.[12][13] Previous ...
"Genetic elimination of dengue vector mosquitoes". Proceedings of the National Academy of Sciences. 108 (12): 4772-4775. Bibcode ... Genetically modified male mosquitoes containing a lethal gene have been developed to combat the spread of dengue fever[147] and ... the Zika virus.[148] Aedes aegypti mosquitoes, the single most important carrier of dengue fever and the Zika virus, were ...
"Dengue". United States Centers for Disease Control and Prevention. 28 March 2016. Retrieved 27 April 2018. Use acetaminophen. ... NSAIDs may increase the risk of bleeding in patients with Dengue fever For this reason, NSAIDs are only available with a ...
Aspirin and ibuprofen should not be taken in cases of dengue fever as it could increase the risk of bleeding and cause Dengue ... Gubler, D. J. (1998). "Dengue and dengue hemorrhagic fever". Clinical Microbiology Reviews. 11 (3): 480-496. doi:10.1128/CMR. ... Genus Flavivirus Mosquito-borne viruses Dengue virus group Dengue virus Japanese encephalitis virus group Japanese encephalitis ... Tambyah, P. A.; Koay, E. S. C.; Poon, M. L. M.; Lin, R. V. T. P.; Ong, B. K. C.; Transfusion-Transmitted Dengue Infection Study ...
Therefore, its use as a diagnostic test for dengue is questioned as people who have a negative test may still have dengue. It ... 2011). "Predictive diagnostic value of the tourniquet test for the diagnosis of dengue infection in adults". Trop Med Int ... Hess test WHO (2009). Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control (PDF). ISBN 978-92-4-154787-1. " ... 2006). "Repeated tourniquet testing as a diagnostic tool in dengue infection". Med J Malaysia. 61: 22-7.. ...
He also highlighted the importance of dengue, a related mosquito-borne virus, as a cause of neurological disease. He works on ... Dengue. In: Nath A, Berger J, editors. Clinical Neurovirology. Marcel Decker, New York NY. pp. 469-516. "Scientist wins pounds ... "Neurological manifestations of dengue infection". The Lancet. 355 (9209): 1053-1059. doi:10.1016/S0140-6736(00)02036-5. PMID ...
Wilder-Smith, Annelies; Ooi, Eng-Eong; Horstick, Olaf; Wills, Bridget (January 2019). "Dengue". The Lancet. 393 (10169): 350- ...
Halstead, Scott B. (2009-03-31). Dengue. Imperial College Press. ISBN 9781848162297. Retrieved 2012-05-20. Jules Dubos, René; ...
A Dengue fever outbreak in 2016 killed 20 patients. Cases of the disease were reported from all 12 districts of Ouagadougou.[ ...
"Dengue Vaccine Registered in 18 Countries". dengue.info. Sanofi Pasteur. Retrieved 2 February 2018.[self-published source] ... "Pharma firm issues caution on use of anti-dengue vaccine". Inquirer.net. Retrieved 2 April 2018. "DOH suspends dengue ... The victims' parents blamed the dengue vaccine for the deaths of their children. In July 2020, Sanofi Pasteur announced that it ... Dengue vaccines Dengvaxia, approved in 18 countries DPT vaccines Adacel Daptacel Tripedia (Trepedia), discontinued, last ...
"Fallece el exgobernador Guillermo Cosío Vidaurri; padecía dengue". El Universal. 14 November 2019. v t e. ...
Shoo, dengue!: In this part, a young boy sprays insecticide every time someone says something that remembers dengue. This part ... ends with the boy saying "Shoo, dengue!". She's Crazy!: In this part, a woman is sitting in one of the subway's seat, when a ...
As of 2010, dengue virus is the most prevalent arbovirus and increasingly virulent strains of the virus have spread across Asia ... Ross TM (2010). "Dengue virus". Clinics in Laboratory Medicine. 30 (1): 149-160. doi:10.1016/j.cll.2009.10.007. PMC 7115719. ... The first known cases of dengue fever occurred in Indonesia and Egypt in 1779. Trade ships brought the disease to the US, where ... ISBN 978-0-521-26056-5. Chakraborty, T (2008). Dengue fever and other hemorrhagic viruses (Deadly diseases and epidemics). ...
"Dengue Viruses". www.nature.com. Retrieved 2017-12-19. Colpitts, Tonya M.; Conway, Michael J.; Montgomery, Ruth R.; Fikrig, ... It is a member of the family Flaviviridae, specifically from the genus Flavivirus, which also contains the Zika virus, dengue ... Carro, Ana C.; Damonte, Elsa B. (2013). "Requirement of cholesterol in the viral envelope for dengue virus infection". Virus ... West Nile and dengue viruses". Nature Medicine. 10 (12s): S98-S109. doi:10.1038/nm1144. PMID 15577938. S2CID 9987454. ...
Dengue virus, dengue hemorrhagic fever, dengue fever, flavivirus, Aedes mosquitoes, DHF, DF, DSS ... Forty percent of the worlds population, about 3 billion people, live in areas with a risk of dengue. Dengue is often a leading ... Dengue viruses are spread to people through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito. ... Dengue is common in more than 100 countries around the world. ... Areas with Risk of Dengueplus icon *Dengue Around the World. * ...
... symptomatic dengue virus infections were classified according to the WHO guidelines as dengue fever, dengue hemorrhagic fever ( ... Dengue. Tyler M. Sharp, Janice Perez-Padilla, Stephen H. Waterman. INFECTIOUS AGENT. Dengue, an acute febrile illness, is ... Dengue is defined by a combination of ≥2 clinical findings in a febrile person who traveled to or lives in a dengue-endemic ... Clinicians should consider dengue in a patient who was in an endemic area within 2 weeks of symptom onset. Because dengue is a ...
Four key action points were highlighted to advance our understanding of the epidemiology of dengue in Africa. First, dengue ... Fourth, policy needs to be informed so the necessary steps can be taken to provide dengue vector control and health services. ... Second, representative data need to be collected across Africa to uncover the true burden of dengue. Third, established ... in February 2013 to consider key questions regarding the possible expansion of dengue in Africa. ...
Dengue is an infection caused by a virus. You can get it if an infected mosquito bites you. Learn more about risk and ... Dengue (Centers for Disease Control and Prevention) Also in Spanish * Dengue and Severe Dengue (World Health Organization) Also ... Dengue is an infection caused by a virus. You can get it if an infected mosquito bites you. Dengue does not spread from person ... In some cases, dengue turns into dengue hemorrhagic fever, which causes bleeding from your nose, gums, or under your skin. It ...
Find out what to do about dengue fever - and how to avoid it. ... en españolLa fiebre del dengue. What Is Dengue Fever?. Dengue ( ... Thats when dengue hemorrhagic fever is most likely to develop.). How Can I Prevent Dengue Fever?. You can help keep yourself ... Most cases of dengue fever will go away within a couple of weeks and wont cause any long-term problems. But dengue hemorrhagic ... Dengue fever is not contagious, so it cant spread directly from person to person. Since different viruses can cause dengue ...
dengue (usually uncountable, plural dengues) *An acute febrile disease of the (sub)tropics caused by the Dengue virus, a ... pathology) dengue. Further reading[edit]. *"dengue" in Trésor de la langue française informatisé (The Digitized Treasury of the ... Retrieved from "https://en.wiktionary.org/w/index.php?title=dengue&oldid=59113313" ...
Severe dengue(https://wwwn.cdc.gov/nndss/conditions/severe-dengue/) 2010. 2014. Dengue fever(https://wwwn.cdc.gov/nndss/ ... conditions/dengue-fever/) 2010. 2014. Dengue hemorrhagic fever(https://wwwn.cdc.gov/nndss/conditions/dengue-hemorrhagic-fever/) ... Dengue Virus Infections , 2015 Case Definition (https://wwwn.cdc.gov/nndss/conditions/dengue/case-definition/2015/) ... Dengue virus infections(https://wwwn.cdc.gov/nndss/conditions/dengue-virus-infections/) ...
Even when you consider the cultural cross-pollination that goes on in large metropolitan areas, L.A.s Dengue Fever had perhaps ... About Dengue Fever. Even when you consider the cultural cross-pollination that goes on in large metropolitan areas, L.A.s ... Dengue Fever made their live debut in 2002, with the charismatic Nimol in full traditional Cambodian garb, and soon won a ... Dengue Fever counted among their fans actor Matt Dillon, who included their Khmer-language cover of Joni Mitchells Both Sides ...
Dengue(https://wwwn.cdc.gov/nndss/conditions/dengue/) 2015. Current. Dengue-like illness(https://wwwn.cdc.gov/nndss/conditions/ ... Dengue fever(https://wwwn.cdc.gov/nndss/conditions/dengue-fever/) 2010. 2014. Dengue hemorrhagic fever(https://wwwn.cdc.gov/ ... nndss/conditions/dengue-hemorrhagic-fever/) 2010. 2014. Dengue shock syndrome(https://wwwn.cdc.gov/nndss/conditions/dengue- ... Dengue Virus Infections , 2015 Case Definition (https://wwwn.cdc.gov/nndss/conditions/severe-dengue/case-definition/2015/) ...
Dengue infection is caused by dengue virus (DENV), which is a single-stranded RNA virus (approximately 11 kilobases long) with ... encoded search term (What causes dengue infection?) and What causes dengue infection? What to Read Next on Medscape. Related ... Dengue infection is caused by dengue virus (DENV), which is a single-stranded RNA virus (approximately 11 kilobases long) with ... Istúriz RE, Gubler DJ, Brea del Castillo J. Dengue and dengue hemorrhagic fever in Latin America and the Caribbean. Infect Dis ...
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View MoreMeSH SubjectSevere Dengue (‎206)‎Dengue (‎1)‎Dengue Virus (‎1)‎Date Issued2010 - 2020 (‎28)‎2000 - 2009 (‎316)‎1990 - ... The clinical presentations of dengue disease in adults are not fully described. Differentiating dengue from other acute viral ... Dengue Bulletin.The objective of the Bulletin is to disseminate updated information on thecurrent status of dengue fever/dengue ... Immediate cost of dengue to Malaysia and Thailand: an estimate.  Lee Han, Lim; Vasan, SS; Birgelen, L; Murtola, TM; Gong, HF; ...
Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever ... Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). ... Dengue virus infection induces autophagy: an in vivo study We and others have reported that autophagy is induced by dengue ... Current progress in dengue vaccines Dengue is one of the most important emerging vector-borne viral diseases. There are four ...
"No end to Dengue fever in Punjab." Accessed 12 May 2013. *^ "Unbiased dengue bites Chinese workers as well." Pakistan today.com ... A special tribunal for Dengue fever was empanelled. The chairman of the Dengue Emergency Response Committee was Khawaja Saad ... "Dengue Seminar." Waqt News. you Tube. Accessed 11 September 2011. *^ "Hyderabad Seminar." Geo News. You Tube. Accessed 11 ... Dengue fever is an important infectious disease in Pakistan with increasingly frequent epidemics.[1] Despite the efforts of the ...
Dengue fever is a virus-caused disease that is spread by mosquitoes. ... Dengue fever is rare in the US mainland, but has been found in Florida and Texas. Dengue fever should not be confused with ... Dengue. www.cdc.gov/dengue/index.html. Updated May 3, 2019. Accessed September 17, 2019. ... Dengue fever is caused by 1 of 4 different but related viruses. It is spread by the bite of mosquitoes, most commonly the ...
Fiebre del dengue. What Is Dengue Fever?. Dengue (DEN-gee) fever is a tropical disease caused by a virus carried by mosquitoes ... How Is Dengue Fever Diagnosed?. If you think your child might have dengue fever, call a doctor right away. You should also call ... What Causes Dengue Fever?. Dengue fever is caused by four similar viruses spread by mosquitoes of the genus Aedes, which are ... In rare cases, dengue fever can lead to a more serious form of the disease called dengue hemorrhagic fever (DHF). DHF can be ...
Dengue Eye Disease Manifestations of dengue in the eye, though rare in the past, are now more recently noted to be common in ... Dengue can have various manifestations in the eye, (10)(11) and more recently a newer terminology of "dengue eye disease" has ... Prevalence of dengue maculopathy in patients hospitalized for dengue fever. Ophthalmology. 2007 Sep;114(9):1743-7.. 4) Chee E, ... Recurrent bilateral dengue maculopathy following sequential infections with two serotypes of dengue virus. Eye (Lond). 2009. ...
All About Dengue Fever BY DR.MUHAMMAD ASGHAR (Ph.D) ASSISTANT DIRECTOR OF AGRICULTURE (PP) PEST WARNING & QUALITY CONTROL OF ... 2. Contents 1. What is dengue fever 2. Symptoms of dengue fever 3. World distribution of Dengue 4. Dengue outbreak in Asia and ... So what is dengue fever? Dengue fever is an illness caused by the dengue virus which is spread by the Aedes mosquito. ... Chemical Control of Vector of dengue fever * 3. What is dengue fever? Dengue Fever also known as break bone fever is an illness ...
Researchers have discovered an antibody that prevented dengue infection in mouse models, bringing us a step closer to a vaccine ... Though researchers are working hard to find prevention and treatment strategies for dengue, they face challenges. Dengues four ... such as this human antibody that not only kills dengue virus but also prevents enhanced dengue disease," says Dr. Crowe Jr. ... Dengue is transmitted by a bite from a mosquito - most commonly the Aedes aegypti mosquito - that is infected with one of four ...
Dengue (or, according to Webster 1913 in an uncharacteristically chatty moment, breakbone fever) is a nasty tropical fever that ... Dengue was considered to be non-fatal until the 1950s, when dengue haemorrhagic fever (DHF), a potentially lethal complication ... The atypical mild form of dengue fever usually lasts less than 72 hours. Dengue hemorrhagic fever occurs mainly in Southeast ... to control the mosquitoes which make dengue and malaria endemic there. But I got dengue when I was in Thailand - on an island, ...
LA by-way-of Cambodia collective Dengue Fever are an uncompromising cultural hybrid. Just dont call them fusion. ... Dengue Fever was born.. Merging surf-rock guitars with traditional Cambodian pop, the six-piece strong collective - Chhom Nimol ... Dazed Digital caught up with Dengue Fever to talk about the genesis of the band.... Dazed Digital: You recently played Ray ... Breathing new life into a forgotten era of psych-pop, LA by-way-of Cambodia collective Dengue Fever are an uncompromising ...
Dengue fever is a viral infection commonly found in the tropical and sub-tropical regions that is carried and spread by the ... New way to prevent Dengue Fever. www.healthline.com/.../tech-oxitec-mosquitoes-dengue-fever-032213 ... and in non-dengue patients were 106 318/mm and 41.6% (range 29-53%). Based on WHO criteria for diagnosis of dengue, headache ( ... The proportion of laboratory confirmed dengue patients were 56%. Mean platelet count and PCV in laboratory confirmed dengue ...
There are no specific medications for treating dengue fever. The viral infection usually resolves within a week or two and in ... Severe dengue can also lead to organ damage and internal bleeding and this condition is called dengue hemorrhagic fever. ... In rare cases, patients go on to develop severe dengue, a fatal outcome that can lead to shock or a sudden fall in blood ... If someone starts to bleed from the nose or other sites, they may have dengue hemorrhagic fever, in which case they should be ...
Federal officials report dengue fever infections in Florida. Typically, dengue fever strikes abroad. ... Dengue was also known in Florida in the 1930s, but no locally-acquired cases had been confirmed since then, until last August. ... Dengue is much more of a problem elsewhere in the hemisphere, with an estimated 4.6 million cases from 2000 to 2007 in Mexico, ... Dengue fever is a viral infection transmitted by mosquito bites. It can be debilitating, but is not usually fatal in otherwise ...
The Health Ministry has given conditional registration for the worlds first dengue vaccine to be used in Malaysia. ... The vaccine gives an overall average of 66% protection against dengue infection, 93% against severe dengue and 80% against ... The dengue vaccine is currently approved in 14 other countries, including the Philippines, Indonesia, Thailand and Singapore. ... The agency was also concerned that the vaccine was less effective in reducing dengue incidence caused by DEN1 (58.4%) and DEN2 ...
Some of these cases did not display other typical features of dengue in... more ... Neurologic manifestations such as seizures and encephalitis/encephalopathy have been reported in rare cases of dengue infection ... Istúriz RE, Gubler DJ, Brea del Castillo J. Dengue and dengue hemorrhagic fever in Latin America and the Caribbean. Infect Dis ... A child with dengue hemorrhagic fever or dengue shock syndrome may present severely hypotensive with disseminated intravascular ...
Southeast Asia is scrambling to combat a deadly outbreak of dengue fever, the tropical illness transmitted by mosquitoes, which ... Dengue Fever Sweeps Southeast Asia Thailand, Laos, Singapore See Surge in Mosquito-Borne Illness; Unusually Early Rains Are ... An early rainy season in Southeast Asia has led to an unexpected jump in cases of dengue fever as governments struggle to ... BANGKOK-Southeast Asia is scrambling to combat a deadly outbreak of dengue fever, the tropical illness transmitted by ...
Untreated DHF may result in blood vessel collapse, causing a usually fatal condition known as dengue shock syndrome. Dengue is ... dengue: …a more severe form, called dengue hemorrhagic fever (DHF), which is characterized by hemorrhaging blood vessels and ... Other articles where Dengue hemorrhagic fever is discussed: ... dengue: NS1 proteinThe dengue NS1 protein is thought to play a ... In dengue. …a more severe form, called dengue hemorrhagic fever (DHF), which is characterized by hemorrhaging blood vessels and ...
Dengue fever (breakbone fever) is a mosquito-borne disease. Read about treatment and symptoms, like rash and fever, get vaccine ... Dengue fever is contracted from the bite of a striped Aedes aegypti mosquito. Symptoms and signs of dengue include headache, ... Since dengue is caused by a virus, there is no specific medicine to treat it. Treatment instead focuses on relieving the ... home/travel health center/ travel health a-z list/ dengue fever center ...
  • In some cases, dengue turns into dengue hemorrhagic fever, which causes bleeding from your nose, gums, or under your skin. (medlineplus.gov)
  • What Is Dengue Fever? (kidshealth.org)
  • Dengue (pronounced: DEN-gee) fever is an infectious disease. (kidshealth.org)
  • Although dengue fever can be very painful, it's not usually fatal. (kidshealth.org)
  • Dengue fever is common in tropical and subtropical climates. (kidshealth.org)
  • Dengue fever is rare in the United States, seen only in people who become infected in another country and then travel or immigrate to the U.S. (kidshealth.org)
  • How Do People Get Dengue Fever? (kidshealth.org)
  • When a mosquito bites a person who has dengue fever, the mosquito becomes infected with the virus that causes the disease. (kidshealth.org)
  • Dengue fever is not contagious, so it can't spread directly from person to person. (kidshealth.org)
  • Since different viruses can cause dengue fever, someone can get the disease more than once. (kidshealth.org)
  • What Are the Signs & Symptoms of Dengue Fever? (kidshealth.org)
  • Dengue fever used to be called "breakbone fever," which might give you an idea of the severe bone and muscle pain it sometimes can cause. (kidshealth.org)
  • Symptoms of dengue fever usually appear 4 to 14 days after someone has been infected. (kidshealth.org)
  • Some people can get a more serious form of the infection called dengue hemorrhagic fever . (kidshealth.org)
  • They'll have the regular symptoms of dengue fever for 2 to 7 days. (kidshealth.org)
  • If dengue hemorrhagic fever is not treated right away, a person can have heavy bleeding and a drop in blood pressure, and could even die. (kidshealth.org)
  • People with dengue hemorrhagic fever need to be treated in a medical facility immediately. (kidshealth.org)
  • If you think you might have dengue fever, call a doctor right away. (kidshealth.org)
  • You also should call a doctor if you develop symptoms of the infection after going to a region that has dengue fever. (kidshealth.org)
  • If you've been diagnosed with dengue, call your doctor or get to a hospital emergency room right away if your symptoms get worse or if new symptoms appear, especially in the day or two after the fever goes down. (kidshealth.org)
  • How Is Dengue Fever Treated? (kidshealth.org)
  • Most cases of dengue fever will go away within a couple of weeks and won't cause any long-term problems. (kidshealth.org)
  • But dengue hemorrhagic fever requires treatment in a hospital with intravenous (IV) fluids and close monitoring. (kidshealth.org)
  • That's when dengue hemorrhagic fever is most likely to develop. (kidshealth.org)
  • How Can I Prevent Dengue Fever? (kidshealth.org)
  • You can help keep yourself free of dengue fever by avoiding mosquito bites. (kidshealth.org)
  • There is no vaccine against dengue fever yet. (kidshealth.org)
  • An acute febrile disease of the (sub) tropics caused by the Dengue virus , a flavivirus , transmitted by Aedes mosquitoes , and characterized by high fever , rash , headache , and severe muscle and joint pain . (wiktionary.org)
  • Even when you consider the cultural cross-pollination that goes on in large metropolitan areas, L.A.'s Dengue Fever had perhaps the strangest genesis of any band in recent memory. (apple.com)
  • Formed in L.A.'s hipster-friendly Silver Lake area in 2001, Dengue Fever traced their roots to organist Ethan Holtzman's 1997 trip to Cambodia with a friend. (apple.com)
  • In addition to Ethan Holtzman on Farfisa and Optigan, and Zac on vocals and guitar, the charter membership of Dengue Fever included bassist Senon Williams (also of slowcore outfit the Radar Brothers), drummer Paul Smith, and saxophonist David Ralicke (Beck, Ozomatli, Brazzaville). (apple.com)
  • Dengue Fever made their live debut in 2002, with the charismatic Nimol in full traditional Cambodian garb, and soon won a following among Hollywood hipsters, not to mention L.A. Weekly's Best New Band award that year. (apple.com)
  • Dengue Fever counted among their fans actor Matt Dillon, who included their Khmer-language cover of Joni Mitchell's 'Both Sides Now' on the soundtrack of his 2003 directorial debut, City of Ghosts. (apple.com)
  • In the meantime, Dengue Fever released their self-titled debut album on Web of Mimicry, a label run by Mr. Bungle guitarist Trey Spruance. (apple.com)
  • In 2007, Dengue Fever not only released Escape from Dragon House, but also starred in the documentary Sleeping Through the Mekong, which saw them performing their music in Cambodia for the first time. (apple.com)
  • Spatial and temporal dynamics of dengue fever in Peru: 1994-2006. (medscape.com)
  • Capillary leak syndrome in dengue fever. (who.int)
  • Capillary leak syndrome (‎CLS)‎ has been described in dengue fever but its exact features have not been clearly defined. (who.int)
  • Haemogram profile of dengue fever in adults during 19 September - 12 November 2008: A study of 40 cases from Delhi. (who.int)
  • Involvement of the central nervous system in dengue fever and its outcome. (who.int)
  • Geographical association between socioeconomics and age of dengue haemorrhagic fever patients in Surabaya, Indonesia. (who.int)
  • Dengue fever (‎DF)‎ cases were reported in Delhi during August 2010. (who.int)
  • Dengue fever has become a major global public health problem in Puerto Rico. (who.int)
  • Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). (biomedcentral.com)
  • Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. (biomedcentral.com)
  • There are four serotypes of dengue viruses (DENV), each of which is capable of causing self-limited dengue fever (DF) or even life-thre. (biomedcentral.com)
  • Dengue fever is an important infectious disease in Pakistan with increasingly frequent epidemics . (wikipedia.org)
  • [2] In Pakistan, in the summer of 2011, more than 300 people died of Dengue fever. (wikipedia.org)
  • In November 2010, more than 21,204 people were diagnosed with dengue fever. (wikipedia.org)
  • The secretary of the Punjab Mineral Development Corporation, Ataullah Siddiqui and Ghiasuddin, a member of the Punjab Public Service Commission died as a result of the dengue fever. (wikipedia.org)
  • A special tribunal for Dengue fever was empanelled. (wikipedia.org)
  • A hotline called the "Punjab Health Line Project For Dengue" was opened to facilitate knowledge of the signs and symptoms of dengue fever, provide help people affected and identify areas where the epidemic may have spread. (wikipedia.org)
  • [15] During dengue fever epidemics, the Pakistan army created camps in Lahore city. (wikipedia.org)
  • Dengue fever is a virus-caused disease that is spread by mosquitoes. (medlineplus.gov)
  • Dengue fever is caused by 1 of 4 different but related viruses. (medlineplus.gov)
  • Dengue fever is rare in the US mainland, but has been found in Florida and Texas. (medlineplus.gov)
  • Dengue fever should not be confused with dengue hemorrhagic fever, which is a separate disease caused by the same type of virus, but has much more severe symptoms. (medlineplus.gov)
  • Dengue fever begins with a sudden high fever, often as high as 105°F (40.5°C), 4 to 7 days after the infection. (medlineplus.gov)
  • There is no specific treatment for dengue fever. (medlineplus.gov)
  • Although uncomfortable, dengue fever is not deadly. (medlineplus.gov)
  • Call your health care provider if you have traveled in an area where dengue fever is known to occur and you have symptoms of the disease. (medlineplus.gov)
  • Clothing, mosquito repellent, and netting can help reduce the risk for mosquito bites that can spread dengue fever and other infections. (medlineplus.gov)
  • Dengue (DEN-gee) fever is a tropical disease caused by a virus carried by mosquitoes. (kidshealth.org)
  • Most cases of dengue fever are mild and go away on their own after about a week. (kidshealth.org)
  • Dengue fever rarely strikes in the United States - the last reported outbreak was in Texas in 2005. (kidshealth.org)
  • But if you plan to travel to a foreign country, especially one in the tropics, it's wise to guard against dengue fever. (kidshealth.org)
  • Dengue fever is caused by four similar viruses spread by mosquitoes of the genus Aedes , which are common in tropical and subtropical areas worldwide. (kidshealth.org)
  • If this mosquito bites someone else, that person can be infected with dengue fever. (kidshealth.org)
  • In rare cases, dengue fever can lead to a more serious form of the disease called dengue hemorrhagic fever (DHF). (kidshealth.org)
  • Symptoms of dengue fever are generally mild in younger children and those who have the disease for the first time. (kidshealth.org)
  • How Long Does Dengue Fever Last? (kidshealth.org)
  • How Is Dengue Fever Diagnosed? (kidshealth.org)
  • You should also call a doctor if your child has recently been to a region that has dengue fever and has a fever or severe headache. (kidshealth.org)
  • No specific treatment is available for dengue fever. (kidshealth.org)
  • Pain relievers with acetaminophen can ease the headaches and pain associated with dengue fever. (kidshealth.org)
  • Most cases of dengue fever go away within a week or two and won't cause any lasting problems. (kidshealth.org)
  • To treat severe cases of dengue fever at a hospital, doctors will give intravenous (IV) fluids and electrolytes (salts) to replace those lost through vomiting or diarrhea . (kidshealth.org)
  • Can Dengue Fever Be Prevented? (kidshealth.org)
  • There's no vaccine to prevent dengue fever. (kidshealth.org)
  • Prevalence of dengue maculopathy in patients hospitalized for dengue fever. (bmj.com)
  • So what is dengue fever? (slideshare.net)
  • Dengue fever is an illness caused by the dengue virus which is spread by the Aedes mosquito. (slideshare.net)
  • How do you know if you have dengue fever? (slideshare.net)
  • Symptoms of dengue include fever , severe headache , joint pain, muscle and bone pain, severe pain behind the eyes and mild bleeding - such as nose bleed. (medicalnewstoday.com)
  • A more severe form of the virus is known as dengue hemorrhagic fever (DHF), characterized by prolonged fever, abdominal pain, persistent vomiting, bleeding and breathing problems. (medicalnewstoday.com)
  • When symptoms develop, 3 to 15 days after the bite, one of three broad clinical patterns may be seen: classical dengue, a mild atypical form or hemorrhagic fever . (everything2.com)
  • Classical dengue fever usually lasts only 5 to 6 days and is never fatal . (everything2.com)
  • The atypical mild form of dengue fever usually lasts less than 72 hours . (everything2.com)
  • Dengue hemorrhagic fever occurs mainly in Southeast Asia , particularly in infant s. (everything2.com)
  • Dengue (or, according to Webster 1913 in an uncharacteristically chatty moment, breakbone fever ) is a nasty tropical fever that is transmitted to, and between, humans by mosquito es - mosquito vector s, they're called in epidemiological parlance. (everything2.com)
  • Dengue was considered to be non- fatal until the 1950s, when dengue haemorrhagic fever (DHF), a potentially lethal complication, was recognized. (everything2.com)
  • Breathing new life into a forgotten era of psych-pop, LA by-way-of Cambodia collective Dengue Fever are an uncompromising cultural hybrid. (dazeddigital.com)
  • Dengue Fever was born. (dazeddigital.com)
  • Dazed Digital caught up with Dengue Fever to talk about the genesis of the band. (dazeddigital.com)
  • Dengue fever is a viral infection commonly found in the tropical and sub-tropical regions that is carried and spread by the Aedes aegypti mosquito. (news-medical.net)
  • Retrieved on July 17, 2019 from https://www.news-medical.net/health/Dengue-Fever-Prevention.aspx. (news-medical.net)
  • New way to prevent Dengue Fever. (news-medical.net)
  • The infection was confirmed as dengue fever in 11% and dengue hemorrhagic fever in 89% based on WHO criteria. (news-medical.net)
  • Your article with respect to Dengue Fever is great. (news-medical.net)
  • There are no specific medications for treating dengue fever. (news-medical.net)
  • Severe dengue can also lead to organ damage and internal bleeding and this condition is called dengue hemorrhagic fever. (news-medical.net)
  • Ibuprofen and aspirin, however, should be avoided as these agents can cause internal bleeding in patients with dengue fever. (news-medical.net)
  • If someone starts to bleed from the nose or other sites, they may have dengue hemorrhagic fever, in which case they should be hospitalized. (news-medical.net)
  • In dengue haemorrhagic fever, treatment is aimed at maintaining the patient's circulating fluid volume. (news-medical.net)
  • Dr. Richard Mata, in his article 'Solving Dengue Fever' quoted an example that in an Idiopathic Thrombocytopenic purpura or ITP case a patient remains normal even with 10K platelet count, if the patient is always hydrated. (news-medical.net)
  • May 20, 2010 -- More than two dozen cases of locally-acquired dengue fever have hit the resort town of Key West, Fla., in the past nine months, officials from the U.S Centers for Disease Control and Prevention said. (go.com)
  • Dengue fever is a viral infection transmitted by mosquito bites. (go.com)
  • An early rainy season in Southeast Asia has led to an unexpected jump in cases of dengue fever as governments struggle to control the mosquito populations that transmit the disease. (wsj.com)
  • BANGKOK-Southeast Asia is scrambling to combat a deadly outbreak of dengue fever, the tropical illness transmitted by mosquitoes, which has hit parts of the region especially hard. (wsj.com)
  • dengue: NS1 protein The dengue NS1 protein is thought to play a critical role in severe dengue disease by triggering immune reactions associated with vascular leak and shock, which are the major causes of death in persons suffering from dengue hemorrhagic fever. (britannica.com)
  • a more severe form, called dengue hemorrhagic fever (DHF), which is characterized by hemorrhaging blood vessels and thus bleeding from the nose, mouth, and internal tissues. (britannica.com)
  • Dengue fever is contracted from the bite of a striped Aedes aegypti mosquito. (medicinenet.com)
  • An Aedes aegypti, the mosquito that spreads dengue fever. (wsj.com)
  • SÃO PAULO-Sanofi Pasteur, the vaccine division of France's Sanofi SA, said Monday it has secured approval from Brazilian authorities to market its dengue fever vaccine amid an explosion of cases across Latin America's largest nation. (wsj.com)
  • The first vaccine against dengue fever won clearance in Mexico, an initial step toward preventing a mosquito-borne infection that puts half of the world's population at risk. (japantimes.co.jp)
  • Central Tokyo's Yoyogi Park was to reopen on Friday morning after it was closed for nearly two months due to the threat of mosquitoes carrying dengue fever, the Tokyo Metropolitan Government said. (japantimes.co.jp)
  • His traveling companion comes down with dengue fever, an infectious disease spread by mosquitoes, but guy is simultaneously struck with inspiration and returns to Los Angeles with an idea and an armful of secondhand cassettes. (metroactive.com)
  • Dengue Fever gained notoriety through shows in L.A. and San Francisco, where, Holtzman says, some members of the audience were already familiar with '60s Cambodian pop through the mysterious Cambodia Rocks compilation album released at about the same time. (metroactive.com)
  • Brazil will send 670 health professionals to Rio de Janeiro State to help overwhelmed emergency rooms that are reporting 80 new cases of dengue fever every hour. (nytimes.com)
  • Late last week Texas public health officials confirmed a new wave of dengue fever has cropped up in the southernmost tip of Texas, marking the first outbreak the state has seen since 2005. (huffingtonpost.com)
  • Although cases of dengue fever have occurred in the Lone Star State since 2005, they were typically imported--acquired when a traveler was bitten by an infected mosquito elsewhere in the world. (huffingtonpost.com)
  • Dengue (pronounced DEN-ghee) fever is a tropical disease spread by mosquitoes . (go.com)
  • Dengue Fever: Tropical Disease Hits U.S. (go.com)
  • Some carriers never feel ill, but many sufferers report excruciating bone pain, leading some to call dengue "break-bone fever. (go.com)
  • Why is dengue fever an issue now in the United States? (go.com)
  • It's misleading to think there's been no dengue fever in the United States until now. (go.com)
  • Then, beginning in the 1980s, dengue fever re-emerged as a widespread tropical infection throughout Central America and the Caribbean, especially in Cuba, the Dominican Republic and Puerto Rico. (go.com)
  • The incubation period for dengue fever is typically 4 to 7 days, but can be 3 to 14 days. (go.com)
  • Sequential infections put them at increased risk for dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), which can be fatal. (go.com)
  • DHF is caused by infection with the same viruses that cause dengue fever. (go.com)
  • Dengue shock syndrome (DSS) is dengue hemorrhagic fever with signs of circulatory failure. (go.com)
  • The causes of the infectious disease known as Dengue Fever are the four viruses named and numbered from DEN-1 through DEN-4. (medic8.com)
  • Humans are most commonly infected with Dengue Fever from mosquito bites. (medic8.com)
  • The same viruses that cause Dengue Fever can produce a more critical manifestation of Dengue known as Dengue Haemorrhagic Fever, commonly abbreviated as DHF. (medic8.com)
  • Without treatment, Dengue Haemorrhagic Fever can result in death, but with prompt medical attention, the likelihood of death can be reduced significantly. (medic8.com)
  • Symptoms of Dengue Haemorrhagic Fever are more severe with fevers that can last up to a week. (medic8.com)
  • Sarah Bardeen reviews Escape from Dragon House , a new CD from the group Dengue Fever. (npr.org)
  • Dengue hemorrhagic fever is a more serious form of dengue infection. (medicinenet.com)
  • Primary symptoms of dengue appear three to 15 days after the mosquito bite and include high fever and severe headache , with severe pain behind the eyes that is apparent when trying to move the eyes. (medicinenet.com)
  • Dengue hemorrhagic fever starts with the typical signs and symptoms of dengue as described above. (medicinenet.com)
  • Learn everything you want about Dengue Fever with the wikiHow Dengue Fever Category. (wikihow.com)
  • Learn about topics such as How to Recognize and Treat Dengue Fever , How to Differentiate Between Malaria, Dengue, and Chikungunya , How to Prevent Getting Dengue Fever , and more with our helpful step-by-step instructions with photos and videos. (wikihow.com)
  • More than 4,000 people in Pakistan's Punjab Province have contracted dengue fever as authorities struggle to prevent the disease from spreading, RFE/RL's Radio Mashaal reports. (rferl.org)
  • The dengue virus causes an infectious tropical disease known as dengue fever, which is characterized by headaches, severe joint pain, and a rash. (rferl.org)
  • By infecting disease-carrying mosquitoes with a common natural bacterium called Wolbachia, his team hopes to reduce dengue (aka breakbone) fever infections in humans. (scientificamerican.com)
  • The article "Dengue fever on the rise at tourist getaways" 1 recommends the use of bed nets to reduce the incidence of dengue. (cmaj.ca)
  • Rynor B. Dengue fever on the rise at tourist getaways. (cmaj.ca)
  • The Calcutta Municipal Corporation and Salt Lake municipality did not report any fresh case of dengue on Sunday but doctors said hundreds in the city and its adjacent areas have been suffering from fever with dengue-like symptoms. (telegraphindia.com)
  • Some people develop a more severe illness known as dengue hemorrhagic fever (DHF), which can be fatal if not diagnosed and treated promptly. (babycenter.com)
  • Babies who develop the more severe dengue hemorrhagic fever (DHF) may be hospitalized and given fluid replacement therapy. (babycenter.com)
  • Ibrahim Ali al-Jadari's four teenage daughters lie at home on intravenous drips that will soon run out as they, like tens of thousands of other Yemenis, battle a seasonal surge of dengue fever. (japantimes.co.jp)
  • Central America is grappling with its worst outbreak of dengue fever in decades - and scientists say the disease is likely to spread and become more frequent in the future due to climate change. (japantimes.co.jp)
  • Leading Japanese insecticide manufacturer Earth Corp. plans to expand sales in China and Southeast Asia via a subsidiary in Malaysia, as the risk of dengue fever and malaria in the region drives up demand for repellents. (japantimes.co.jp)
  • In the backyards of rural Cambodia, a tiny weapon is being deployed to fight dengue fever, the world's fastest-spreading tropical disease, which causes debilitating flu-like symptoms and can develop into a deadly hemorrhagic fever. (japantimes.co.jp)
  • The first case of dengue fever was reported on Aug. 27. (japantimes.co.jp)
  • Dengue Outbreak 2015: Dengue Fever - Hawaii Island Outbreak. (babycenter.com)
  • Four closely related dengue serotypes cause the disease, which ranges from asymptomatic infection to undifferentiated fever, dengue fever (DF), and dengue hemorrhagic fever (DHF). (nih.gov)
  • While it may be several weeks before the medical examiner determines the exact cause of death, Irons' family speculates the young athlete succumbed to dengue fever , which he may have contracted during the Rip Curl Pro Search competition in Puerto Rico, an area riddled with disease-carrying mosquitoes. (wired.com)
  • Also known as ' bonebreak fever ,' dengue incapacitates its victims with elevated body temperatures, rashes, and severe joint and muscle pains. (wired.com)
  • Dengue is transmitted to people by the bite of an infected yellow fever mosquito ( Aedes aegypti ) or the Asian tiger mosquito ( Aedes albopictus ), which are found in tropical and temperate zones throughout the world. (virginia.gov)
  • Persons who have been exposed to one variety of dengue virus and are then exposed to a different variety of dengue virus may develop what is called dengue hemorrhagic fever (DHF). (virginia.gov)
  • Symptoms of dengue fever infection usually begin 4-7 days after the infectious mosquito bite and typically last 3-10 days. (virginia.gov)
  • The mosquito-transmitted Dengue virus (DV) is the causative agent of dengue fever (DF), the most prevalent arthropod-borne viral illness in humans with 50-100 million afflicted individuals. (uni-heidelberg.de)
  • DF is characterized by high fever, chills, body aches and skin rash and ranges from mild, flu-like symptoms to severe forms, the so called dengue hemorrhagic fever (DHF), and the dengue shock syndrome (DSS). (uni-heidelberg.de)
  • Here we give you the most important do's and don'ts for dengue fever. (medindia.net)
  • What started as a sonic obsession has turned into a righteous cause for Los Angeles band Dengue Fever . (sfgate.com)
  • Now Dengue Fever is looking to highlight its initial source of inspiration, promoting the release of "Electric Cambodia" - a CD featuring 14 vintage Cambodian rock tunes culled from the band's precious stash of cassettes. (sfgate.com)
  • We've got a heavy relationship with this music," says Dengue Fever bassist Senon Williams . (sfgate.com)
  • While Dengue Fever didn't set out with a political agenda, the group has grown increasingly involved with Cambodia. (sfgate.com)
  • Paraguay is bracing for a potential major epidemic of Dengue fever after recording close to 7,000 suspected cases in the first two weeks of 2020, similar to levels in the severe 2013 outbreak that led to 250 deaths. (nasdaq.com)
  • ASUNCION, Jan 17 (Reuters) - Paraguay is bracing for a potential major epidemic of Dengue fever after recording close to 7,000 suspected cases in the first two weeks of 2020, similar to levels in the severe 2013 outbreak that led to 250 deaths. (nasdaq.com)
  • Health authorities in the landlocked South American nation are also investigating 10 deaths potentially linked to Dengue, after confirming that a 68-year-old man had died from the disease, which causes high fever and joint pain. (nasdaq.com)
  • Dengue fever is a constant problem in more than 100 countries in Africa, the Americas, the eastern Mediterranean, South East Asia and the western Pacific. (abc.net.au)
  • And it's not just found in warmer climates - last year France had its first case of locally spread dengue fever thought to have been spread by another species of mosquito, Aedes albopictus , which can live in cooler climates. (abc.net.au)
  • Dengue is a mosquito-borne virus which can cause fever, headaches, rash and joint and muscle pain. (abc.net.au)
  • Some people who are infected will not have any symptoms, but others can develop a potentially fatal complication known as dengue haemorrhagic fever. (abc.net.au)
  • Dengue fever is caused by four distinct, but closely related, dengue viruses. (abc.net.au)
  • The risk of haemorrhagic fever increases if you catch dengue more than once. (abc.net.au)
  • The dengue fever is a relatively mild febrile illness with rash whereas the dengue hemorrhagic fever is a more severe, sometimes lethal disease. (pnas.org)
  • At least 2.5 billion people who live in areas of the world where dengue occurs are at risk of developing dengue fever (DF) and its severe complications, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). (nih.gov)
  • As many as 80% of people infected with dengue virus have no symptoms or mild fever whereas others develop more severe symptoms of dengue fever. (yahoo.com)
  • Dengue (DENG-gey) fever is a mosquito-borne disease that occurs in tropical and subtropical areas of the world. (yahoo.com)
  • Mild dengue fever causes a high fever, rash, and muscle and joint pain. (yahoo.com)
  • A severe form of dengue fever, also called dengue hemorrhagic fever, can cause severe bleeding, a sudden drop in blood pressure (shock) and death. (yahoo.com)
  • Dengue fever is most common in Southeast Asia and the western Pacific islands, but the disease has been increasing rapidly in Latin America and the Caribbean. (yahoo.com)
  • Researchers are working on dengue fever vaccines. (yahoo.com)
  • For now the best prevention is to reduce mosquito habitat in areas where dengue fever is common. (yahoo.com)
  • Many people, especially children and teens, may experience no signs or symptoms during a mild case of dengue fever. (yahoo.com)
  • Dengue fever causes a high fever - 104 F degrees - and at least two of the following symptoms: 1. (yahoo.com)
  • This can cause a severe form of dengue fever, called dengue hemorrhagic fever, severe dengue or dengue shock syndrome. (yahoo.com)
  • Signs and symptoms of dengue hemorrhagic fever or severe dengue - a life-threatening emergency - include: 1. (yahoo.com)
  • Dengue fever is caused by any one of four types of dengue viruses spread by mosquitoes that thrive in and near human lodgings. (yahoo.com)
  • After you've recovered from dengue fever, you have immunity to the type of virus that infected you - but not to the other three dengue fever virus types. (yahoo.com)
  • The risk of developing severe dengue fever, also known as dengue hemorrhagic fever, actually increases if you're infected a second, third or fourth time. (yahoo.com)
  • Factors that put you at greater risk of developing dengue fever or a more severe form of the disease include: 1. (yahoo.com)
  • Living or traveling in tropical areas.Being in tropical and subtropical areas increases your risk of exposure to the virus that causes dengue fever. (yahoo.com)
  • 2. Prior infection with a dengue fever virus .Previous infection with a dengue fever virus increases your risk of having severe symptoms if you're infected again. (yahoo.com)
  • If severe, dengue fever can damage the lungs, liver or heart. (yahoo.com)
  • One dengue fever vaccine, Dengvaxia, is currently approved for use in those ages 9 to 45 who live in areas with a high incidence of dengue fever. (yahoo.com)
  • The vaccine is approved only for older children because younger vaccinated children appear to be at increased risk of severe dengue fever and hospitalization two years after receiving the vaccine. (yahoo.com)
  • The World Health Organization stresses that the vaccine is not an effective tool, on its own, to reduce dengue fever in areas where the illness is common. (yahoo.com)
  • FILE - Dengue fever is spread by mosquitoes. (voanews.com)
  • Taiwanese officials are reporting their most severe outbreak of dengue fever ever. (voanews.com)
  • Dengue fever has touched nearly every part of Asia and regularly threatens about 1.8 billion people in the region. (voanews.com)
  • Dengue fever cases spiked this year from the annual average of 1,000 to 2,000 because of high heat and the Taiwanese habit of collecting fresh water - that quickly breeds mosquitoes as it stands. (voanews.com)
  • Lin Sheng-che, health department director in Tainan, the Taiwanese city with the most dengue fever cases this year, points to standing water as the chief aggravator. (voanews.com)
  • Around Asia dengue fever cases have grown over the past 45 years because of population growth, migration to cities and warmer temperatures. (voanews.com)
  • Huang Yu-ling, who got dengue fever for a week in August, is one of those cases. (voanews.com)
  • Aedes aegypti (Dengue Fever Mosquito) is a species of flies in the family Mosquitos . (eol.org)
  • Known occurrences, collected specimens and observations of Dengue fever mosquito. (eol.org)
  • NEW DELHI] Communities and their religious and political leaders must join the battle against dengue fever in Asia, say the authors of a study on how the disease could be contained. (scidev.net)
  • This development means that in the foreseeable future there may be viable genetic approaches to controlling dengue virus in the field, which could limit human suffering and mortality," said Akbari, whose lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. (newswise.com)
  • Mosquitoes have been given the bad rap of being the deadliest killers on the planet because they are the messengers that transmit diseases like malaria, dengue, chikungunya, Zika and yellow fever that collectively put 6.5 billion people at risk globally," said Suresh Subramani, professor emeritus of molecular biology at UC San Diego and global director of the Tata Institute for Genetics and Society (TIGS). (newswise.com)
  • Dengue fever is a common mosquito-borne illness in many tropical and subtropical countries. (healthline.com)
  • However, the infection can progress into a more serious condition known as severe dengue or dengue hemorrhagic fever. (healthline.com)
  • The more severe symptoms of dengue hemorrhagic fever often develop after you start to recover from the dengue virus. (healthline.com)
  • Dengue hemorrhagic fever can occur when someone is bitten by a mosquito or exposed to blood infected with the dengue virus. (healthline.com)
  • Repeated exposure to the dengue virus can make it more likely that you will develop dengue hemorrhagic fever. (healthline.com)
  • Who Is at High Risk for Dengue Hemorrhagic Fever? (healthline.com)
  • You may feel like you are recovering from dengue fever, and then suddenly develop new and severe symptoms. (healthline.com)
  • These could be symptoms of dengue hemorrhagic fever. (healthline.com)
  • Doctors will usually diagnose the type of dengue virus and then begin to look for signs of dengue hemorrhagic fever. (healthline.com)
  • Severe dengue fever is often more difficult to treat because the symptoms are worse and appear at a faster rate. (healthline.com)
  • The outlook for dengue hemorrhagic fever depends on how early the condition is detected. (healthline.com)
  • Dengue fever is not common in the United States, but travelers to areas of dengue epidemics can be at a high risk of infection. (healthline.com)
  • The acting American Samoa Governor, Lemanu Peleti Mauga, has declared a public health emergency following the confirmation of 3 people with dengue fever by the Hawaii State Laboratory. (radionz.co.nz)
  • Program will demonstrate use of computational drug delivery technology to enhance dengue fever vaccines. (prweb.com)
  • This effort takes the initial steps toward developing the world's first vaccine capable of rapidly generating complete, lasting protection from dengue fever and will establish a new state-of-the-art in adjuvant design by using computational methods. (prweb.com)
  • Dengue fever incidence has grown exponentially over the past 50 years and now causes disease in nearly 100 million people annually. (prweb.com)
  • L.A. group Dengue Fever revive the '60s golden era of Cambodian psychedelic pop with this track from their album 2008 Venus on Earth . (nationalgeographic.com)
  • Through the Arts Envoy Program of the Bureau of Educational and Cultural Affairs, the U.S. Department of State is pleased to bring the rock band Dengue Fever back to Southeast Asia," said Acting Deputy Assistant Secretary of State for Public Diplomacy in the Bureau of East Asian and Pacific Affairs, Thomas Hodges. (concordmusicgroup.com)
  • Dengue Fever, whose exotic blend of Cambodian rock, Afro grooves, surf, and garage psych returns with Cannibal Courtship , the group's first studio album since 2008's Venus on Earth and their Fantasy Records/Concord Music Group debut. (concordmusicgroup.com)
  • Before it was partly Cambodian and partly indie rock," explains Dengue Fever bassist Senon Gaius Williams of the band's evolution. (concordmusicgroup.com)
  • Brothers Ethan (keyboards) and Zac (guitar) Holtzman started Dengue Fever in 2001. (concordmusicgroup.com)
  • Research from the United Kingdom showed limiting global warming could help avoid more than three million annual cases of dengue fever. (medicaldaily.com)
  • A new macromolecule is designed to fight off an array of deadly viral infections, including the Zika virus, Ebola, and dengue fever. (medicaldaily.com)
  • A new study suggests that chikungunya is commonly misdiagnosed as the similar dengue fever. (medicaldaily.com)
  • Dengue fever has been known for over two centuries and is particularly common during and after the rainy season in the tropical and subtropical regions of Africa, South-East Asia and China, India, the Middle East, Latin and Central America, Australia and several areas of the Pacific. (iss.it)
  • Dengue fever is caused by a virus that is spread through the bite of an infected mosquito. (bphc.org)
  • Who gets dengue fever? (bphc.org)
  • Dengue fever can occur in persons of any age and is more likely to occur in persons who have recently traveled to affected areas. (bphc.org)
  • How is dengue fever spread? (bphc.org)
  • Dengue fever is spread through the bite of an infected mosquito ( Aedes aegypti mosquito). (bphc.org)
  • Dengue fever usually starts suddenly with a high fever, severe headache, pain behind the eyes and joint, bone and muscle pain. (bphc.org)
  • A more severe form of the illness, called dengue hemorrhagic fever (DHF), can start with a fever for 2 to 7 days followed by vomiting, difficulty breathing and stomach pain. (bphc.org)
  • Dengue fever may occur 3 to 14 days after a bite from an infected mosquito (usually within 4 to 7 days). (bphc.org)
  • Can a person get dengue fever again? (bphc.org)
  • A person is only protected against the type of dengue fever virus they have been infected with and will not gain protection from the other types of dengue fever virus. (bphc.org)
  • Therefore, a person could get dengue fever 4 times. (bphc.org)
  • What is the treatment for dengue fever? (bphc.org)
  • however, those with dengue fever should get plenty of rest, drink plenty of fluids and if they feel worse 24 after their fever goes away, they should see a healthcare provider immediately. (bphc.org)
  • If a person thinks they have dengue fever, they can take medication such as acetaminophen (Tylenol ®) for the pain but should avoid aspirin. (bphc.org)
  • The best way to prevent dengue fever is to limit your exposure to mosquitoes and their breeding areas by using mosquito repellent, mosquito netting, and wearing a long-sleeved shirt and pants when traveling to affected areas. (bphc.org)
  • Mosquitoes that have dengue fever tend to live indoors and are often found in dark, cool places. (bphc.org)
  • If 1960s Cambodian pop revival doesn't sound like your cup of tea, maybe you just haven't heard the multi-culti rock group Dengue Fever , brainchild of brothers Zac and Ethan Holtzman, which has been making waves in the Los Angeles music scene. (motherjones.com)
  • When my brother was traveling in Cambodia, his traveling companion came down with dengue fever. (motherjones.com)
  • DHAKA (Reuters) - Bangladesh is grappling with its worst outbreak of dengue fever, with hospitals packed with patients as the disease spreads rapidly in the densely-populated country. (reuters.com)
  • BOSTON, May 4 (UPI) -- The spread of dengue fever could cause more sickness and prove more costly globally than malaria, U.S. public health experts said. (upi.com)
  • Study co-author Donald Shepard of Brandeis University's Schneider Institutes for Health Policy said dengue fever inflicts a $37.8 million burden on Puerto Rico each year, but every $1 invested in traditional surveillance and prevention could save $5 in costs associated with the illness. (upi.com)
  • Dengue fever is a disease caused by one of four related viruses transmitted to humans by the bite of an infected mosquito. (maine.gov)
  • The disease can have severe manifestations, including dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). (maine.gov)
  • DHF is a severe form of dengue fever manifesting with the classical symptoms of dengue, but the patient may also develop vomiting, abdominal pain, difficulty breathing and leaky blood vessels. (maine.gov)
  • There is no specific medication for treatment of dengue fever, but supportive treatments are available. (maine.gov)
  • In the last 20 years the incidence of dengue fever epidemics has increased and hyperendemic transmission has been established over a geographically expanding area. (pnas.org)
  • A severe form, dengue hemorrhagic fever (DHF), is an immunopathologic disease occurring in persons who experience sequential dengue infections. (pnas.org)
  • A potential vaccine to protect children from the worldwide scourge of dengue fever was somewhat successful in a trial among Asian children. (newsday.com)
  • While the vaccine only prevented dengue fever in 56 percent of the 10,000 kids who got the full series of three shots, it protected more than 88 percent of them from severe disease. (newsday.com)
  • In the worst-case scenarios, dengue fever can lead to hospitalization, and sometimes death. (newsday.com)
  • For more on dengue fever, visit the U.S. Centers for Disease Control and Prevention . (newsday.com)
  • Dengue mHealth: Punjab uses smartphones to eradicate breakbone fever. (slate.com)
  • LAHORE, Pakistan-Could smartphones help increase the accountability of government workers and stamp out outbreaks of dengue fever? (slate.com)
  • Each year, more than 100 million people worldwide catch dengue fever, a viral disease that has also been dubbed "breakbone fever" for the excruciating joint and muscle pain it causes. (slate.com)
  • Government entomologists check standing water for Aedes aegypti mosquito larvae, the species of mosquito that acts as a vector for dengue fever. (slate.com)
  • MIAMI, Sept. 29 (UPI) -- The confirmation of a second case of locally acquired dengue fever in Florida's Miami-Dade County means the disease is endemic in the county, officials say. (upi.com)
  • Southeast Asian nations are worried about a surge in dengue fever this year. (voanews.com)
  • In Malaysia, more than 20,000 people caught dengue fever in the first five months of this year, 50 percent more than in the same period a year earlier. (voanews.com)
  • Dengue fever is also on the rise in Vietnam and Thailand. (voanews.com)
  • Ngan Chantha, director of Cambodia's national anti-dengue fever program, fears the death toll could rise even more in coming months. (voanews.com)
  • Chantha says he is worried because it is only June, and dengue fever usually peaks at the height of the rainy season in July and August. (voanews.com)
  • As greenhouse gases raise temperatures in Europe, writes Tim Radford, British researchers warn that the risk is increasing of the arrival of dengue fever and other mosquito-borne killer tropical diseases. (theecologist.org)
  • Add one more horror to the list of awful threats that climate change poses: it could introduce dengue fever in Europe. (theecologist.org)
  • Dengue fever is already a hazard for 2.5 billion people in humid tropical regions, and 50-100 million people a year are infected by the mosquito-borne disease. (theecologist.org)
  • Their computer simulation already has support from medical records: the mosquito exists in urban Europe, and in 2010 there were isolated cases of dengue fever reported in Croatia and in France. (theecologist.org)
  • "The exact incidence of dengue fever is dependent on several other factors, some of which we were unable to model at this stage" , Prof Hunter said. (theecologist.org)
  • Cases of dengue haemorrhagic fever (DHF), a potentially fatal complication, have also increased - from just more than 13,000 cases in the 1980s to more than 100,000 cases between 2000 and 2007. (scidev.net)
  • In a small proportion of cases, the disease develops into a more severe dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. (wikipedia.org)
  • A vaccine for dengue fever has been approved and is commercially available in a number of countries. (wikipedia.org)
  • Paracetamol (acetaminophen) is recommended instead of nonsteroidal anti-inflammatory drugs (NSAIDs) for fever reduction and pain relief in dengue due to an increased risk of bleeding from NSAID use. (wikipedia.org)
  • Typically, people infected with dengue virus are asymptomatic (80%) or have only mild symptoms such as an uncomplicated fever. (wikipedia.org)
  • Therefore, travelers returning from endemic areas are unlikely to have dengue fever if symptoms start more than 14 days after arriving home. (wikipedia.org)
  • The characteristic symptoms of dengue are sudden-onset fever, headache (typically located behind the eyes), muscle and joint pains, and a rash. (wikipedia.org)
  • An alternative name for dengue, "breakbone fever", comes from the associated muscle and joint pains. (wikipedia.org)
  • Dengue vaccine is a vaccine used to prevent dengue fever in humans. (wikipedia.org)
  • The vaccine is only recommended in those who have previously had dengue fever or populations in which most people have been previously infected. (wikipedia.org)
  • CYD-TDV, sold under the brand name Dengvaxia and made by Sanofi Pasteur, is a live attenuated tetravalent chimeric vaccine made using recombinant DNA technology by replacing the PrM (pre-membrane) and E (envelope) structural genes of the yellow fever attenuated 17D strain vaccine with those from the four dengue serotypes. (wikipedia.org)
  • In all cases of dengue infection, efforts should be made to keep the infected person from being bitten by mosquitoes. (kidshealth.org)
  • Mosquitoes cannot transmit the dengue virus amongst themselves, they need to first bite a person who is already infected with the dengue virus. (slideshare.net)
  • The mosquitoes that carry dengue are day-biters, not night-biters like the ones that spread malaria . (everything2.com)
  • The Thai government has instituted a number of measures, from DDT in the fifties to larvae suffocating agents now, to control the mosquitoes which make dengue and malaria endemic there. (everything2.com)
  • Dengue is a viral illness transmitted by day-biting mosquitoes in many tropical areas. (emoryhealthcare.org)
  • Health experts suspect that an unusually early rainy season that brought mosquitoes out in April, months ahead of what is expected, contributed to the seriousness of the dengue challenge. (wsj.com)
  • The news came on the heels of reporting in Scientific American about how scientists are trying to uncover why the mosquito-borne infection is cropping up in Florida but not in other regions of the nation that host the same Aedes aegypti species of dengue-carrying mosquitoes. (huffingtonpost.com)
  • Now, with the uptick in Texas cases as well, scientists are reexamining how, or if, it's possible to "harden" locations that host significant populations of dengue-carrying mosquitoes against outbreaks beyond telling people to beware of standing water and to wear long sleeves. (huffingtonpost.com)
  • Epidemiologists say dengue could have reappeared in Florida when an infected international visitor passed the virus to local mosquitoes, or a mosquito carrying dengue hopped a ride on a cruise ship or airplane. (go.com)
  • Dengue outbreaks can occur in any tropical and urban locations around the globe because the Aedes aegypti and Aedes albopictus mosquitoes inhabit such areas. (medic8.com)
  • Infection rate of Aedes aegypti mosquitoes with dengue virus depends on the interaction between temperature and mosquito genotype. (umn.edu)
  • Now, he writes, the time has come to set these infected insects free in certain locations so that they can mate with native bugs and spread Wolbachia -and thus resistance to dengue-among mosquitoes in the wild. (scientificamerican.com)
  • Health workers of the Calcutta Municipal Corporation, keen on preventing a renewed outbreak of dengue, are on a door-to-door visit to check whether mosquitoes are breeding in tubs, flower vases, refrigerator trays or other objects, officials said. (telegraphindia.com)
  • However, dengue is transmitted by day-active mosquitoes, with significantly high peak periods of activity in the early morning and, especially, early to late evening. (cmaj.ca)
  • The guidelines say all premises in a locality must be systematically searched for accumulated clean water, where Aedes aegypti mosquitoes that cause dengue breed. (telegraphindia.com)
  • Once the vector specimens mosquitoes, larvae and pupae are collected, they are to be dissected to find out whether the dengue virus is lodged inside. (telegraphindia.com)
  • Dengue is an illness caused by a virus transmitted to people by certain mosquitoes. (babycenter.com)
  • Aedes mosquitoes, which cause dengue, are endemic to the region. (sify.com)
  • Foreign governments criticized Indian officials for building the athletes village too close to the Yamuna River, a known hotbed for dengue-infected mosquitoes . (wired.com)
  • Last week, British biotechnology company Oxitec announced a new large-scale trial underway in Malaysia that literally kicks the dengue-carrying insect hosts where it counts, modifying the mosquitoes' ability to reproduce. (wired.com)
  • Dengue is a tropical disease caused by mosquitoes carrying the dengue virus. (medindia.net)
  • Dengue cases in Paraguay peak in the southern hemisphere summer months, when mosquitoes that transmit the disease proliferate. (nasdaq.com)
  • Inside are a clutch of biologically modified Aedes aegypti mosquitoes - a distinctive species of mosquito with white banded legs that is notorious around the world as the main carrier of the dengue virus. (abc.net.au)
  • As the dengue season escalates in Far North Queensland, the project's scientists are closely monitoring the small communities of Yorkeys Knob and Gordonvale where they are releasing 6000 modified mosquitoes each week until the end of March. (abc.net.au)
  • While dengue is on the rise globally, there is currently no specific treatment, no vaccine and no easy way to control the mosquitoes that spread the disease. (abc.net.au)
  • The World Health Organization estimates 50 million dengue infections occur worldwide annually, spread by dengue mosquitoes infected with one of four types of dengue virus - DEN-1, DEN-2, DEN3, and DEN-4. (abc.net.au)
  • The biologically modified mosquitoes inside these boxes have the potential to stop the spread of dengue. (abc.net.au)
  • In the past, scientists have investigated specific anti-viral treatments for dengue, with little success, meaning the most promising methods of control are through vaccination or biological management of dengue mosquitoes. (abc.net.au)
  • The Eliminate Dengue project, led by Professor Scott O'Neill, a medical entomologist from the University of Queensland , is focusing on taking out the mosquitoes using a biological control. (abc.net.au)
  • The hope is that these mozzies will breed with wild populations, passing the bacteria onto their offspring and creating ongoing generations of dengue-free mosquitoes. (abc.net.au)
  • Wolbachia , a naturally occurring bacterium, found in many insects, was first investigated for its ability to shorten the mosquitoes' life-span, stopping them from reaching the age where they could transmit dengue. (abc.net.au)
  • Our staff are well trained by health department who possess the capability of differentiating between larvae and dengue mosquitoes. (com.pk)
  • The study, carried out in six Asian cities, sought out the breeding sites of dengue-carrying mosquitoes and considered how communities could limit the water sources that sustain the insects. (scidev.net)
  • An international team of scientists has synthetically engineered mosquitoes that halt the transmission of the dengue virus. (newswise.com)
  • The development marks the first engineered approach in mosquitoes that targets the four known types of dengue, improving upon previous designs that addressed single strains. (newswise.com)
  • A team led by Omar Akbari's lab at UC San Diego has engineered the first mosquitoes that repel the four known times of dengue virus. (newswise.com)
  • Led by biologists at the University of California San Diego, the research team describes details of the achievement in Aedes aegypti mosquitoes, the insects that spread dengue in humans, on January 16 in the journal PLOS Pathogens . (newswise.com)
  • They then designed the antibody "cargo" to be synthetically expressed in female A. aegypti mosquitoes, which spread the dengue virus. (newswise.com)
  • This paper shows that it is possible to immunize mosquitoes and prevent their ability to transmit dengue virus, and potentially other mosquito-borne pathogens. (newswise.com)
  • Mosquitoes become infected with the dengue virus when they bite infected people, and then spread it when they bite another person. (healthline.com)
  • Dengue is a viral disease caused by one of four very similar viruses (Den-1, Den-2, Den-3 and Den-4), and is transmitted to humans through the bites of mosquitoes that have previously bitten an infected person. (iss.it)
  • Dengue cannot be spread directly from person to person but via infected mosquitoes, officials said, urging Miami-Dade residents to drain all standing water and use mosquito repellents. (upi.com)
  • In an attempt to control dengue, China has set up the world's largest mosquito factory, where 1 million mosquitoes are sterilized every week. (ibtimes.com)
  • Amid researchers and medical experts' longtime search for new ways to control the spread of dengue, one of the most deadly diseases caused by viral transmission facilitated by mosquitoes, there's an innovative approach from China: The country has established the world's largest mosquito factory -- sterilized mosquitoes, that is -- releasing 1 million into the environment every week. (ibtimes.com)
  • The researchers believe that releasing such " sterilized mosquitoes " into the environment helps dilute the population of the mosquitoes that carry dengue virus. (ibtimes.com)
  • Dengue viruses normally need to replicate in mosquitoes. (ibtimes.com)
  • Dengue is transmitted primarily by Aedes aegypti mosquitoes and mosquito control is the only prevention method. (scidev.net)
  • Dengue is spread by several species of female mosquitoes of the Aedes genus, principally Aedes aegypti. (wikipedia.org)
  • Climate Change and Aedes Vectors: 21st Century Projections for Dengue Transmission in Europe. (medscape.com)
  • When an Aedes mosquito bites a person who has been infected with a dengue virus, the mosquito can become a carrier of the virus. (kidshealth.org)
  • Now I'll tell you about the Aedes mosquito which spreads dengue. (slideshare.net)
  • We all know by now that the Aedes mosquito spreads the dengue virus, but how exactly do they do it? (slideshare.net)
  • Dengue is transmitted by a bite from a mosquito - most commonly the Aedes aegypti mosquito - that is infected with one of four dengue virus serotypes, known as DENV1-4. (medicalnewstoday.com)
  • A single bite from the Aedes aegypti mosquito is often enough to transmit the dengue infection and adequate protection against mosquito bites is important. (news-medical.net)
  • In areas with mosquito species capable of transmitting the virus -- such as Aedes aegypti and Aedes albopictus, both present in the southern and southeastern U.S. -- dengue can then spread locally. (go.com)
  • Dengue is transmitted through the bite of the female mosquito Aedes aegypti. (wsj.com)
  • It is caused by any one of four closely related dengue viruses -- DENV 1, DENV 2, DENV 3 or DENV 4 -- carried most often by the Aedes aegypti mosquito, and less frequently, by Aedes albopictus. (go.com)
  • Key West has lots of Aedes aegypti, a mosquito that is the most effective dengue carrier. (go.com)
  • The species of mosquito called Aedes aegypti is the predominant vector of the dengue virus in the Western Hemisphere. (medic8.com)
  • An exception was the Dengue outbreak that occurred in Hawaii in 2001, which was transmitted by the species Aedes albopictus instead. (medic8.com)
  • Dengue is caused by one of four dengue viruses (dengue virus types 1-4 or DENV 1-4) that are transmitted by the bite of an infected Aedes aegypti mosquito that has previously bitten an infected person. (medicinenet.com)
  • Dengue virus is carried by the Aedes aegypti mosquito, the same type that can spread Zika virus. (cnn.com)
  • This is a female Aedes mosquito, which spreads dengue virus. (scientificamerican.com)
  • Dengue is an endemic disease in Paraguay and is transmitted by the bite of the Aedes Aegypti mosquito. (nasdaq.com)
  • Published in this month's Bulletin of the World Health Organization , the study surveyed a range of public and private spaces in urban areas to unpick the biological, ecological and social determinants of Aedes aegypti , the dengue mosquito vector. (scidev.net)
  • FILE PHOTO: An aedes aegypti mosquito with the dengue-blocking Wolbachia bacteria is seen inside a laboratory tube before being released in Rio de Janeiro, Brazil August 29, 2017. (reuters.com)
  • The dengue virus is spread by the Aedes aegypti mosquito which has grown rapidly along with urbanization and globalization because it thrives in tropical mega-cities and is easily spread in goods containing small puddles of water. (reuters.com)
  • At the root of the emergence of dengue as a major health problem are changes in human demography and behavior, leading to unchecked populations of and increased exposure to the principal domestic mosquito vector, Aedes aegypti. (pnas.org)
  • Aedes larvae tend to be larger than that of of the Culex mosquito, which doesn't carry dengue. (slate.com)
  • The Wolbachia is known to live inside the cells of an insect only and has the ability to kill the dengue virus cells that the Aedes mosquito carry. (ibtimes.com)
  • The Aedes aegypti mosquito - vector for dengue disease - biting a human. (theecologist.org)
  • Dengue is endemic throughout the tropics and subtropics and is a leading cause of febrile illness among travelers returning from Latin America, the Caribbean, and Southeast Asia. (cdc.gov)
  • The vaccine is approved for use in children aged 9 to 16 years with laboratory-confirmed previous dengue virus infection and living in areas where dengue is endemic (common). (cdc.gov)
  • An infectious disease specialist was called in, who inquired about travel to dengue-endemic areas. (go.com)
  • Seven are believed to have been locally acquired (rather than contracted when traveling to a dengue-endemic region), according to the Texas Department of State Health Services (DSHS). (huffingtonpost.com)
  • Co-circulation of chikungunya and dengue viruses in dengue endemic region of New Delhi, India during 2016. (umn.edu)
  • In the United States, 57 cases of dengue have been reported in Key West in the past two years, and just last week, Miami-Dade county announced the first endemic case in over 50 years. (wired.com)
  • DV infection has been described in more than 100 countries, with 2.5 billion people living in dengue endemic areas. (uni-heidelberg.de)
  • Dengue is an endemic problem in several countries including India. (medindia.net)
  • Dengue is endemic to the jungle region but until now Peru has largely dealt with the American strain of the disease. (abc.net.au)
  • It has also said its recommendations on use of Dengvaxia were conditional and confined to children aged 9 and older in areas where dengue was endemic. (reuters.com)
  • Dengue is endemic in at least 100 countries in Asia, the Pacific, the Americas, Africa and the Caribbean. (maine.gov)
  • In the United States, dengue is endemic in Puerto Rico, the U.S. Virgin Islands and the U.S. territories in the Pacific Ocean, Sharp said. (newsday.com)
  • The pipeline remains active with two late-phase live-attenuated vaccines (LAVs), Takeda's TAK-003 and Merck & Co's TV003/TV005, in development in dengue-endemic regions. (globenewswire.com)
  • and various other developers in India, the Middle East, and Asia-Pacific markets, with the goal of ensuring market access by facilitating cheaper domestic production in key dengue-endemic regions. (globenewswire.com)
  • Given that most dengue-endemic regions consist of low-income countries, they are unlikely to implement the necessary serostatus screening programs that would allow identification of individuals eligible to receive Dengvaxia. (globenewswire.com)
  • In May 2019, Dengvaxia was approved in the United States as the first vaccine approved for the prevention of dengue disease caused by all dengue virus serotypes (1, 2, 3 and 4) in people ages nine through 16 who have laboratory-confirmed previous dengue infection and who live in endemic areas. (wikipedia.org)
  • Dengue is endemic in the U.S. territories of American Samoa, Guam, Puerto Rico and the U.S. Virgin Islands. (wikipedia.org)
  • The safety and effectiveness of the vaccine was determined in three randomized, placebo-controlled studies involving approximately 35,000 individuals in dengue-endemic areas, including Puerto Rico, Latin America and the Asia Pacific region. (wikipedia.org)
  • Dengue, an acute febrile illness, is caused by infection with any of 4 related positive-sense, single-stranded RNA viruses of the genus Flavivirus , dengue viruses 1, 2, 3, or 4. (cdc.gov)
  • In addition, perinatal dengue transmission occurs when the mother is infected near the time of birth, in which infection occurs via microtransfusions when the placenta is detached or through mucosal contact with mother's blood during birth. (cdc.gov)
  • Symptomatic infection (dengue) most commonly presents as a mild to moderate, nonspecific, acute febrile illness. (cdc.gov)
  • Approximately 2.5-4 billion persons, 40%-60% of the world's population, live in areas at risk for dengue virus (DENV) infection ( 1 , 2 ). (cdc.gov)
  • Dengue is an infection caused by a virus. (medlineplus.gov)
  • What causes dengue infection? (medscape.com)
  • Dengue infection is caused by dengue virus (DENV), which is a single-stranded RNA virus (approximately 11 kilobases long) with an icosahedral nucleocapsid and covered by a lipid envelope. (medscape.com)
  • Fatal hemophagocytic lymphohistiocytosis associated with locally acquired dengue virus infection - new Mexico and Texas, 2012. (medscape.com)
  • This series, published in Journal of Biomedical Science , highlights recent advances in the research field of dengue virus infection. (biomedcentral.com)
  • Serologically defined primary dengue virus infection and/or subsequent homologous serotype infection is known to be associated with less severe disease as compared with secondary subsequent heterologous seroty. (biomedcentral.com)
  • What is more, the researchers found the 2D22 antibody also prevented cross-reaction of other antibodies, which reduced the risk of infection with a second dengue serotype. (medicalnewstoday.com)
  • People should make sure they are aware of whether there is a risk of dengue infection and be ready to protect themselves if they are travelling to a region where infection is common. (news-medical.net)
  • The vaccine gives an overall average of 66% protection against dengue infection, 93% against severe dengue and 80% against hospitalisation for dengue, for those aged between nine and 16. (thestar.com.my)
  • Neurologic manifestations such as seizures and encephalitis/encephalopathy have been reported in rare cases of dengue infection. (medscape.com)
  • Some of these cases did not display other typical features of dengue infection. (medscape.com)
  • Other neurologic complications associated with dengue infection include neuropathies, Guillain-Barré syndrome, and transverse myelitis. (medscape.com)
  • Although dengue symptoms, when mild, can seem flulike, there is no vaccine or treatment for the infection other than staying hydrated and taking acetaminophen to manage the pain. (huffingtonpost.com)
  • DHF is a very dangerous form of dengue infection. (go.com)
  • The controversial dengue vaccine should not be used until clinicians can confirm prior dengue infection, and such a test is at least 2 years away. (umn.edu)
  • Characterization of recent and minimally passaged Brazilian dengue viruses inducing robust infection in rhesus macaques. (umn.edu)
  • Co-circulation and simultaneous co-infection of dengue, chikungunya, and Zika viruses in patients with febrile syndrome at the Colombian-Venezuelan border. (umn.edu)
  • Immune status alters the probability of apparent illness due to dengue virus infection: evidence from a pooled analysis across multiple cohort and cluster studies. (umn.edu)
  • Epidemiological significance of dengue virus genetic variation in mosquito infection dynamics. (umn.edu)
  • Dengue infection in India: a systematic review and meta-analysis. (umn.edu)
  • Dengue infection is a leading cause of death and sickness in tropical and subtropical parts of the world. (medicinenet.com)
  • Six months later, they injected all 41 volunteers with a weakened, 'challenge' version of the dengue virus-which usually causes symptoms similar to a mild dengue infection, such as a rash. (scientificamerican.com)
  • The study published today tested only whether the vaccine prevented infection with dengue serotype 2-the most difficult to protect against. (scientificamerican.com)
  • Dengue infection with organ impairment mainly involves the central nervous system and the liver. (nih.gov)
  • There is no specific medication for treatment of a dengue infection other than supportive care. (virginia.gov)
  • Infections with one serotype confers a long-lasting immunity to re-infection with the same DV serotype but on the other hand increases the risk of severe dengue manifestation upon infection with a heterologous serotype. (uni-heidelberg.de)
  • Millions of cases of dengue infection occur worldwide each year. (yahoo.com)
  • People who receive care in the early stages of dengue infection will often recover - according to the Mayo Clinic , this usually happens within a week. (healthline.com)
  • The CDC keeps an up-to-date health map to show areas that have recent reports of dengue infection. (healthline.com)
  • However, it has acknowledged that clinical tests of the vaccine did not fully investigate whether a previous dengue infection could influence the outcome. (reuters.com)
  • Rather than being protective, a shot given to someone who had never had dengue could act like a first infection, increasing their risk of severe dengue when they were exposed a second time. (reuters.com)
  • There is not enough education about dengue - how to prevent infection and how to eradicate breeding sites. (ipsnews.net)
  • Dengue virus may cause a mild to severe viral infection. (drugs.com)
  • My brother's daughter was down with dengue infection too. (deccanherald.com)
  • however, those who have previously been infected with other serotypes of dengue virus ("secondary infection") are at an increased risk. (wikipedia.org)
  • In 2017, the manufacturer recommended that the vaccine only be used in people who have previously had a dengue infection, as outcomes may be worsened in those who have not been previously infected. (wikipedia.org)
  • See Box 4-02 for information regarding the World Health Organization guidelines for classifying dengue. (cdc.gov)
  • [25] The World Health Organization provided technical guidance along with support for provincial and territorial dengue monitoring and coordination committees. (wikipedia.org)
  • According to the World Health Organization (WHO), more than 22,000 people worldwide die from dengue each year, the majority of whom are children. (medicalnewstoday.com)
  • Dengue infects about 390 million people a year world-wide, 96 million of whom require treatment, according to the World Health Organization. (wsj.com)
  • GENEVA (Reuters) - The World Health Organization supported a decision by the Philippines Department of Health on Tuesday to suspend vaccinations with Sanofi's dengue drug Dengvaxia, the WHO said in a statement. (reuters.com)
  • According to the World Health Organization, dengue virus threatens millions of people in tropical and sub-tropical climates. (newswise.com)
  • And the threat is only increasing: "The global incidence of dengue has grown dramatically in recent decades," according to the World Health Organization. (slate.com)
  • The World Health Organization (WHO) recommends that countries should consider vaccination with the dengue vaccine CYD-TDV only if the risk of severe dengue in seronegative individuals can be minimized either through pre-vaccination screening or recent documentation of high seroprevalence rates in the area (at least 80% by age nine years). (wikipedia.org)
  • Dengue viruses may also be transmitted through breast milk. (cdc.gov)
  • Cities spawn epidemic dengue viruses. (medscape.com)
  • We and others have reported that autophagy is induced by dengue viruses (DVs) in various cell lines, and that it plays a supportive role in DV replication. (biomedcentral.com)
  • Research is being done on a vaccination for dengue, though the task is complicated by the fact that four viruses are involved. (everything2.com)
  • Scientists have discovered new antibodies that neutralize viruses that cause dengue, potentially putting a universal vaccine within reach for a mosquito-borne illness that strikes an estimated 400 million people a year. (japantimes.co.jp)
  • Dengue viruses reproduce more rapidly in warm weather, according to Robert S. Hope of Yale University. (go.com)
  • Dengue is a disease caused by any one of four closely related dengue viruses. (virginia.gov)
  • Dengue viruses are members of the Flaviviridae, transmitted principally in a cycle involving humans and mosquito vectors. (pnas.org)
  • One of the difficulties in making a dengue vaccine is that you have to cover for four different viruses at the same time," Sharp explained. (newsday.com)
  • The vaccine wasn't equally effective against all four dengue viruses. (newsday.com)
  • This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. (springer.com)
  • At present, there are no vaccines or specific medications for dengue. (medicalnewstoday.com)
  • Currently, there are no vaccines to protect against the dengue virus and people are advised instead to take sensible precautions to decrease the likelihood of being bitten by the mosquito. (news-medical.net)
  • The lack of human challenge studies, he said, has "actually been one of the things that has made the development of dengue vaccines very difficult. (scientificamerican.com)
  • Current dengue vaccines only protect a proportion of volunteers, so if these results hold up in larger populations the vaccine could be one of the most promising dengue vaccines developed. (scientificamerican.com)
  • Several pharmaceutical companies are furiously working on vaccines for dengue, with the most advanced (Phase III) candidate developed by Sanofi-Aventis . (wired.com)
  • The control of dengue is further challenged by the lack of effective therapies, vaccines, and point-of-care diagnostics. (nih.gov)
  • There are currently no licensed vaccines to prevent dengue, nor drugs to treat dengue illness. (prweb.com)
  • How Close Are We To Vaccines For Zika, Dengue, And Chikungunya? (medicaldaily.com)
  • What's the latest news on vaccines for the mosquito-borne diseases Zika, chikungunya, and dengue? (medicaldaily.com)
  • Still, both doctors expect increasing investment in vaccines and vaccine-related research as global warming expands the range of the mosquito that transmits dengue into southern Europe and the United States. (ipsnews.net)
  • Wilder-Smith, who authored an accompanying journal editorial, noted that other dengue vaccines are being tested, but it will take several years before those vaccines reach phase 3 trials. (newsday.com)
  • HOUSTON: The mosquito-borne deadly dengue virus that infects about 400 million people globally every year - especially in the tropic and sub-tropic regions of the world - is undergoing changes that are helping it evade vaccines and therapeutics, according to a study. (indiatimes.com)
  • Dublin, April 19, 2021 (GLOBE NEWSWIRE) -- The "Disease Analysis: Dengue Vaccines" report has been added to ResearchAndMarkets.com's offering. (globenewswire.com)
  • The dengue vaccines market is expected to expand rapidly following the anticipated launch of TAK-003 in 2021/22. (globenewswire.com)
  • GlaxoSmithKline, the Walter Reed Army Institute of Research (WRAIR), and the Oswaldo Cruz Foundation have evaluated a tetravalent purified formalin-inactivated virus vaccine, DPIV, though as GlaxoSmithKline does not list any dengue vaccines in its pipeline, it is unclear whether the company intends to further develop the vaccine. (globenewswire.com)
  • They call for the implementation of PAHO's Integrated Management Strategy for Dengue Prevention and the development of vaccines to protect against the four types of dengue virus. (scidev.net)
  • Development of dengue vaccines began in the 1920s, but was hindered by the need to create immunity against all four dengue serotypes. (wikipedia.org)
  • Visit the Centers for Disease Control and Prevention website at https://www.cdc.gov/dengue/ . (virginia.gov)
  • This vaccine has already proven to be safe," said Tyler Sharp, an epidemiologist in the dengue branch of the U.S. Centers for Disease Control and Prevention, who had no role in the trial. (newsday.com)
  • There are several distinct but related virus es that cause dengue, and recovery from one gives a lifelong immunity to that strain, but not the others. (everything2.com)
  • Comparison of prevalence of dengue maculopathy during two epidemics with differing predominant serotypes. (bmj.com)
  • Published in Nature Immunology , the study detailed the discovery of an antibody that can neutralize all four dengue serotypes . (medicalnewstoday.com)
  • The dengue virus has proved a difficult vaccine target because it comes in four versions, or serotypes. (scientificamerican.com)
  • Investigators have already begun a second human-challenge study to test whether the vaccine protects against dengue serotype 3, and they hope to go on to test it against serotypes 1 and 2. (scientificamerican.com)
  • Cocirculation of multiple dengue (DEN) serotypes in the Western Hemisphere, 2006-2010. (nih.gov)
  • According to the Lancet report, Sanofi's vaccine offers some protection against three of the four serotypes of the dengue virus - about 30 percent against serotype one and from 80 to 90 percent against serotypes three and four. (ipsnews.net)
  • With an estimated annual total of 390 million infections, dengue is the most frequent mosquito-borne viral disease worldwide ( 3 ). (cdc.gov)
  • A complex interplay among virus, dendritic cells, T cells, and cytokines in dengue virus infections. (medscape.com)
  • Differentiating early adult dengue from acute viral respiratory infections - A comparative analysis. (who.int)
  • Differentiating dengue from other acute viral respiratory infections (‎ARIs)‎ is important. (who.int)
  • The tally of confirmed dengue infections in Key West eventually grew to 28, with the most recent case diagnosed in mid-April. (go.com)
  • An estimated 50 million to 100 million dengue infections occur worldwide yearly, and severe forms of the disease can be fatal, especially among children. (huffingtonpost.com)
  • A AAAS general resource animation on mosquito-borne infections caused by the dengue virus. (scientificamerican.com)
  • Cells expressing NS4B or infected with dengue virus do not exhibit nuclear signal transducer and activator of transcription (STAT) 1 on treatment with IFN-β or IFN-γ, indicating that NS4B might be involved in blocking IFN signaling during dengue virus infections. (pnas.org)
  • Dengvaxia prevents dengue infections slightly more than half the time. (yahoo.com)
  • Mosquito-borne dengue is the world's fastest-growing infectious disease, afflicting up to 100 million people worldwide, causing half a million life-threatening infections and killing about 20,000 people, mostly children, each year. (reuters.com)
  • The majority of dengue infections in the US are acquired elsewhere by travelers or immigrants, however there have been outbreaks of dengue in Hawaii, Texas, and Florida. (maine.gov)
  • It can also become dengue shock syndrome, which causes massive bleeding and shock. (medlineplus.gov)
  • In rare cases, patients go on to develop severe dengue, a fatal outcome that can lead to shock or a sudden fall in blood pressure referred to as dengue shock syndrome. (news-medical.net)
  • Untreated DHF may result in blood vessel collapse, causing a usually fatal condition known as dengue shock syndrome. (britannica.com)
  • Dengue shock syndrome in Jamaica. (bmj.com)
  • Fraser H S , Wilson W A , Thomas E J , Sissons J G . Dengue shock syndrome in Jamaica. (bmj.com)
  • A senior Loreto health official, Hugo Rodriguez, says this dengue strain is known as the Asian-American variety, and unlike the American variety produces severe shock among victims. (abc.net.au)
  • Bara Hindu rao Hospital recently reported the death of a six-month-old girl due to dengue while AIIMS saw a 21-year-old man and a 45-year-old man succumbing to dengue shock syndrome. (deccanherald.com)
  • Cost and burden of dengue and chikungunya from the Americas to Asia. (who.int)
  • The ten studies in this special issue document the substantial and growing burden of dengue in the Americas, Africa and Asia, and the burden of a chikungunya outbreak in India. (who.int)
  • The re-emergence of dengue in Florida as well as the threat posed to the U.S. from other emerging mosquito-borne arboviruses (e.g., chikungunya) emphasizes the necessity for strong vector-borne surveillance and mosquito control infrastructure to rapidly identify and control outbreaks of dengue or other mosquito-borne diseases," MMWR's editors wrote in a commentary accompanying the report. (go.com)
  • Seroprevalence of dengue and chikungunya virus antibodies, French Polynesia, 2014-2015. (umn.edu)
  • Clinical and laboratory profile of Zika and dengue infected patients: lessons learned from the co-circulation of dengue, Zika and chikungunya in Brazil. (umn.edu)
  • Effectiveness and economic assessment of routine larviciding for prevention of chikungunya and dengue in temperate urban settings in Europe. (umn.edu)
  • Dengue is one of a few mosquito-borne illnesses, along with Zika and chikungunya that can be problematic or even dangerous for pregnant women and babies. (babycenter.com)
  • THE INDORE unit of Indian Medical Association (IMA) held a symposium on ?Chikungunya and Dengue: An overview? (hindustantimes.com)
  • THE INDORE unit of Indian Medical Association (IMA) held a symposium on "Chikungunya and Dengue: An overview" yesterday which shed light on the various clinical aspects of the two mosquito-borne diseases. (hindustantimes.com)
  • Dr Abhay Bhagwat spoke on the neurological perspective, Dr B K Sethia spoke on the diabetic perspective, Dr Pradeep Salgia on metabolic perspective, Dr Alkesh Jain on the cardiological perspective while Dr Manish Agrawal spoke on the radiological perspective in connection with the two diseases - chikungunya and dengue. (hindustantimes.com)
  • Dr Salgia suggested that fluids (IV or oral) should be administered in large quantities to the patients with chikungunya or dengue. (hindustantimes.com)
  • The participating doctors were equivocal about lack of efforts on the part of IMA in waking up the government on the issue of the epidemic like situation with respect to chikungunya and dengue. (hindustantimes.com)
  • She denied having been out of the country, but said she had received multiple mosquito bites during her Key West visit, and she was tested for dengue antibodies, which came back positive. (go.com)
  • When a mosquito bites a person infected with a dengue virus, the virus enters the mosquito. (yahoo.com)
  • Most cases of the dengue virus are caused when a mosquito bites someone, but you can get the virus if you are exposed to infected blood. (healthline.com)
  • Refining the global spatial limits of dengue virus transmission by evidence-based consensus. (medscape.com)
  • Statler J, Mammen M, Lyons A, Sun W. Sonographic findings of healthy volunteers infected with dengue virus. (medscape.com)
  • Global spread of dengue virus types: mapping the 70 year history. (medscape.com)
  • Dengue virus: molecular basis of cell entry and pathogenesis, 25-27 June 2003, Vienna, Austria. (medscape.com)
  • Interaction of dengue virus envelope protein with endoplasmic reticulum-resident chaperones facilitates dengue virus production. (medscape.com)
  • Macrophages (Mϕ) are the major source of inflammatory cytokines and aretarget cells for dengue virus (DV) replication. (biomedcentral.com)
  • The infected mosquito will then carry the dengue virus and pass it onto a healthy person when it bites him/her and causing them to fall sick. (slideshare.net)
  • Worldwide, there are around 390 million cases of dengue a year - a potentially deadly mosquito-borne virus. (medicalnewstoday.com)
  • Study co-author Dr. James Crowe Jr., of Vanderbilt University in Nashville, TN, and colleagues have uncovered a human antibody that prevented dengue in mouse models by stopping the virus from binding to target cells. (medicalnewstoday.com)
  • Scientists in the antibody discovery group of the Vanderbilt Vaccine Center continue to make great strides in developing novel antiviral drugs, such as this human antibody that not only kills dengue virus but also prevents enhanced dengue disease," says Dr. Crowe Jr. (medicalnewstoday.com)
  • The multiplication of the mosquito that carries the dengue virus can be prevented by ensuring all areas are clear of potential breeding sites. (news-medical.net)
  • According to the ministry, DEN1 and DEN2 are currently the most common dengue virus strains in Malaysia. (thestar.com.my)
  • Since dengue is caused by a virus, there is no specific medicine to treat it. (medicinenet.com)
  • In some tropical regions, they transmit a powerful virus called dengue that kills hundreds of thousands of people each year. (japantimes.co.jp)
  • When a mosquito has bitten an individual infected with Dengue, the mosquito is able to spread the virus to other people after a short period of approximately one week. (medic8.com)
  • The Americas now have all types of the Dengue virus present since the DEN-3 was reintroduced in 1994 to Central America. (medic8.com)
  • The findings add to the conundrum that governments face, as the vaccine prevents hospital stays in children who have antibodies to the dengue virus. (umn.edu)
  • NIH officials said dengue virus is now spreading to other parts of Pakistan. (rferl.org)
  • Scientists have found what may be the strongest evidence yet that a vaccine can prevent dengue, by deliberately infecting volunteers with a weakened form of the disease-causing virus. (scientificamerican.com)
  • This is an incredible paper that shows what is absolutely necessary to develop a vaccine against the dengue virus," says Scott Halstead, a virologist and vaccinologist at the Uniformed Services University of the Health Sciences in Bethesda, Maryland. (scientificamerican.com)
  • The scientists who ran the study also hope to use the human-challenge strategy to speed the development of a vaccine against Zika virus, which is related to dengue. (scientificamerican.com)
  • Takeda Pharmaceutical Co.'s experimental dengue vaccine was highly effective at preventing the mosquito-borne disease in a late stage study, but it failed to protect against one type of the virus in people with no prior exposure to dengue. (japantimes.co.jp)
  • A new vaccine for the dengue virus is taking a potentially risky road to prevent the mosquito-borne disease that infects nearly 400 million people each year. (japantimes.co.jp)
  • Brazilian scientists have developed a biosensor that can quickly detect dengue and could help create a cheap tool to diagnose the painful mosquito-borne virus that infects millions each year. (japantimes.co.jp)
  • The government said Monday that a man in Shizuoka Prefecture is infected with a dengue virus that has a different genetic sequence than the virus first detected in Japan in August. (japantimes.co.jp)
  • Dengue is especially dangerous for pregnant women because they can transmit the virus to their baby during pregncy or during birth. (babycenter.com)
  • Laboratory diagnosis includes virus isolation, serology, and detection of dengue ribonucleic acid. (nih.gov)
  • Dengue can also be diagnosed by testing whole blood samples by RT-PCR to isolate the virus (detect the viral RNA). (virginia.gov)
  • Dengue virus is a worldwide-distributed mosquito-borne flavivirus with a positive strand RNA genome. (pnas.org)
  • Although dengue virus-infected cells seem to be resistant to the antiviral action of IFN, the viral products that mediate this resistance are unknown. (pnas.org)
  • Therefore, we have analyzed the ability of the 10 dengue virus-encoded proteins to antagonize the IFN response. (pnas.org)
  • We found that expression in human A549 cells of the dengue virus nonstructural proteins NS2A, NS4A, or NS4B enhances replication of an IFN-sensitive virus. (pnas.org)
  • Dengue virus life cycle and potential antiviral targets. (nih.gov)
  • Jul 13, 2020 · A multidisciplinary team from The University of Texas Medical Branch at Galveston has uncovered a new mechanism for designing antiviral drugs for dengue virus . (yahoo.com)
  • The DOH suspended its dengue immunisation programme following a Sanofi advisory late in November that said the vaccine itself may, in some cases, increase the risk of severe dengue in recipients not previously infected by the virus. (reuters.com)
  • Dengue virus rarely causes death. (healthline.com)
  • There are four different types of the dengue virus. (healthline.com)
  • It is possible to be infected with all four different types of the dengue virus in your lifetime. (healthline.com)
  • Living in or traveling to Southeast Asia, South and Central America, sub-Saharan Africa, and parts of the Caribbean can increase your risk of contracting the dengue virus. (healthline.com)
  • The mosquito becomes infected with dengue virus when it bites a person who has dengue virus in their blood. (bphc.org)
  • Virus-specified factors also influence the epidemiology of dengue. (pnas.org)
  • New research notes that one of the strains of the Dengue virus, DENV2 has smooth spherical surface particles while growing at the carrier mosquito's physiological temperature of 290 Celsius and transforms into bumpy ones at the human physiological temperature of 370 Celsius. (indiatimes.com)
  • For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. (springer.com)
  • What is dengue virus? (drugs.com)
  • Dengue virus is carried by mosquitos. (drugs.com)
  • How is dengue virus spread? (drugs.com)
  • Dengue virus may be passed from a mother to her unborn baby. (drugs.com)
  • You may be at risk for dengue virus if you travel or live in an area with infected mosquitos. (drugs.com)
  • How is dengue virus diagnosed and treated? (drugs.com)
  • There is no cure for Dengue virus. (drugs.com)
  • You will be monitored closely for problems caused by Dengue virus. (drugs.com)
  • How can I help prevent the spread of dengue virus? (drugs.com)
  • There is currently no vaccine to prevent Dengue virus. (drugs.com)
  • Do not travel to areas where Dengue virus is common. (drugs.com)
  • Dengvaxia is not approved in the U.S. for use in individuals not previously infected by any dengue virus serotype or for whom this information is unknown. (wikipedia.org)
  • Dengvaxia is a weakened but live vaccine and works by triggering an immune response against four types of dengue virus. (wikipedia.org)
  • Dengue is often a leading cause of illness in areas with risk. (cdc.gov)
  • Osterwell N. Dengue 'Under-recognized' as Source of Febrile Illness in US. (medscape.com)
  • Dengue illness appears similar to other febrile illnesses in its early stages, which means its diagnosis is often delayed or confused with other illnesses. (who.int)
  • Dengue is a flu -like illness that lasts, typically, from three days to about a week. (everything2.com)
  • As a result, several other recent cases of febrile illness with other symptoms such as headache, myalgia, chills, and vomiting, were discovered to be dengue. (go.com)
  • The editors also recommended that physicians consider dengue when evaluating any patient with a febrile illness who has recently been in subtropical areas of the U.S., as well as in countries to the south. (go.com)
  • Dengue rarely shows up in the United States but is a leading cause of illness and death in the tropics and subtropics. (babycenter.com)
  • See our article on how to protect your baby from dengue if you are travelling to a place where the illness is common. (babycenter.com)
  • Severe dengue is a leading cause of serious illness and death among children in many Asian and Latin American countries. (newswise.com)
  • Dengue is a leading cause of illness and death in tropical and subtropical areas. (maine.gov)
  • Over the past 30 years, a few cases of locally-acquired dengue have been confirmed along the Texas-Mexico border, according to the report, authored by CDC researchers, public health officials in Florida, and physicians who treated the first cases in the new Key West outbreak. (go.com)
  • Public health officials in the county where Key West is located were informed, and they notified local physicians and the public of the potential for locally acquired dengue. (go.com)
  • In 2013 cases in southern Florida continue to rise, with a total of 23 reports of locally acquired dengue afflicting 21 Floridians and two out-of-state-residents living in Martin and Miami-Dade counties. (huffingtonpost.com)
  • As she announced in January 2016 that the Philippines would immunize 1 million children with a new dengue vaccine, the nation's then health secretary Janette Garin boasted it was a world-first and a tribute to her country's "expertise" in research. (japantimes.co.jp)
  • It sometimes surfaces in Hawaii (there was a dengue outbreak on the Big Island in 2015-2016) and is common in Puerto Rico and in many popular tourist destinations in Latin America, Southeast Asia, and the Pacific islands. (babycenter.com)
  • Over the period 1999 through 2009, the incidence of dengue in Brazil has shown an upward trend with more than 700 000 cases per year reported during 2002 and 2008. (who.int)
  • Usually, the incidence of dengue sees a spike between end-October and November. (telegraphindia.com)
  • In recent decades, the incidence of dengue has grown in many tropical regions. (iss.it)
  • Puerto Rico experienced its largest outbreak ever of dengue in 2010, with 22,648 cases reported for an incidence rate of 57 per 10,000 people. (upi.com)
  • SANTIAGO] Dengue cases in Central and Latin America have increased almost five-fold in incidence in the last 30 years, researchers have found. (scidev.net)
  • Forty percent of the world's population, about 3 billion people, live in areas with a risk of dengue. (cdc.gov)
  • PETALING JAYA: The Health Ministry has given conditional registration for the world's first dengue vaccine to be used in Malaysia. (thestar.com.my)
  • The world's first, large-scale dengue vaccine efficacy study demonstrated its efficacy and a reduction of dengue disease severity with a good safety profile in a study of more than 30,000 volunteers from Asia and Latin America. (nih.gov)
  • CHICAGO/LONDON (Reuters) - When French drugmaker Sanofi published the results of clinical trials of children given its dengue vaccine two years ago, the overall findings were that it protected against the world's biggest and fastest growing mosquito-borne disease. (reuters.com)
  • New research from Johns Hopkins researchers and others finds that the world's first approved dengue vaccine may do more harm than good in certain areas of the world. (medicaldaily.com)
  • The major symptom of dengue is high along with severe headache, severe pain behind the eyes, joint pain, muscle and/or bone pain, rash, mild bleeding of the nose or gums, easy bruising, a low white cell count, and a low platelet count. (virginia.gov)
  • After being infected with one type of dengue you are immune to that specific type for life, but not the other three. (abc.net.au)
  • But in case of dengue, there are chances, these might surface here also, he said. (hindustantimes.com)
  • But the trial also showed that in the third year after receiving the Dengvaxia inoculation, younger children were more likely to end up in hospital with a severe case of dengue than those who didn't get the vaccine. (reuters.com)
  • Avoid areas with epidemics of Dengue. (medic8.com)
  • Repeated reemergences of dengue in sudden explosive epidemics often cause public alarm and seriously stress healthcare systems. (nih.gov)
  • Dengue epidemics still have good days ahead of them. (ipsnews.net)
  • DON WISEMAN: Well the government is clearly really concerned and concerned about this serotype 2 strain, that it's going to have a more substantial impact than the dengue outbreaks in most recent years. (radionz.co.nz)
  • Dengue is a mosquito-borne viral disease, which is currently an expanding global problem. (nih.gov)
  • Dengue is a systemic arthropod-borne viral disease of major global public health importance. (nih.gov)
  • There is no vaccine for dengue, a mosquito-borne viral disease. (abc.net.au)
  • Dengue is now the most rapidly spreading mosquito-borne viral disease in the world. (scidev.net)
  • Dengue is a viral disease transmitted mainly by a type of mosquito common in Southeast Asia. (voanews.com)
  • Dengue begins abruptly after an incubation period of 5-7 days (range, 3-10 days), and the course follows 3 phases: febrile, critical, and convalescent. (cdc.gov)
  • Warning signs of progression to severe dengue occur in the late febrile phase around the time of defervescence and include persistent vomiting, severe abdominal pain, fluid accumulation, mucosal bleeding, difficulty breathing, lethargy/restlessness, postural hypotension, liver enlargement, and progressive increase in hematocrit (hemoconcentration). (cdc.gov)
  • Dengue cases are on the rise. (cdc.gov)
  • The " Seet Quek Lim triad" of flashes of light, floaters and blurring of vision (29) may now warrant an ophthalmic consult and if not requested may be construed as negligence if eventually the patient loses vision, because dengue vision loss can be irreversible and may be seen in up to 10 percent of cases and has potential to cause bilateral irreversible visual impairment or blindness as reported. (bmj.com)
  • If it is uveitis it may recover well with steroids like some reports suggest (35) but bilateral cases like vasculitis and macular oedema (36) one may need to use newer medications and even 66 years after eye manifestations of dengue were first reported (37) ,dengue continues to blind people and greater awareness and timely referral is important even today. (bmj.com)
  • Although not the first cases of home-grown dengue in the U.S., or even in Florida, the outbreak highlights the need for physician vigilance regarding this and other formerly exotic tropical diseases, the CDC said in the May 21 issue of Morbidity and Mortality Weekly Report. (go.com)
  • Dengue was also known in Florida in the 1930s, but no locally-acquired cases had been confirmed since then, until last August. (go.com)
  • Dengue is much more of a problem elsewhere in the hemisphere, with an estimated 4.6 million cases from 2000 to 2007 in Mexico, the Caribbean, and Central and South America, according to MMWR's editors. (go.com)
  • The number of suspected dengue cases in Brazil is soaring. (wsj.com)
  • Through Nov. 14, the number of suspected dengue cases in Brazil this year reached 1.5 million, soaring from 555,400 cases registered over the same period in 2014, according to the most recent figures available from the health ministry. (wsj.com)
  • The dengue outbreak in southern Texas's Cameron County and neighboring Hidalgo County comes after there had been an uptick in cases directly across the Texas-Mexico border in Tamaulipas over the last couple of months. (huffingtonpost.com)
  • The new cases announced last week mark the first actual outbreak of dengue on either side of the border. (huffingtonpost.com)
  • We've seen in Cameron County over the last several weeks more dengue cases than we would expect," says Chris Van Deusen, a spokesman for DSHS. (huffingtonpost.com)
  • Right now, CDC officials are keeping a close eye on Puerto Rico, where suspected dengue cases are being recorded at a level unseen since a major epidemic in 1998. (go.com)
  • Besides, 50 dengue cases have been reported from these hospitals alone. (hindustantimes.com)
  • But data procured from the Municipal Corporation of Delhi (MCD) revealed that so far this year only five dengue cases have been reported and no deaths. (hindustantimes.com)
  • This data from four of the largest private hospitals in the city reveal that less than one in 10 dengue cases in Delhi are making it to the MCD database. (hindustantimes.com)
  • The hospital has treated 14 lab-confirmed dengue cases since this January, compared to 12 in the corresponding period in 2010. (hindustantimes.com)
  • On Saturday, the minister of state for health, Chandrima Bhattacharya, had said 64 cases of dengue had been detected in Calcutta till August 7. (telegraphindia.com)
  • Leave alone three years, the health department or the civic body does not have the exact number of dengue cases this year, said an official. (telegraphindia.com)
  • Days after the games began, Delhi was hit with another wave of dengue cases , though the athletes themselves were relatively unscathed. (wired.com)
  • In rare cases dengue can be transmitted in organ transplants or blood transfusions from infected donors, and there is evidence of transmission from an infected pregnant mother to her fetus. (virginia.gov)
  • As dengue cases came to the fore in several parts of western and northern India, hundreds of people have been admitted to hospitals. (medindia.net)
  • There's no-one debating that the actual number of dengue cases are increasing year on year, partly due to the travel people are doing [and] urbanisation," says Professor John McBride, an infectious diseases physician and clinical microbiologist from James Cook University , in Cairns. (abc.net.au)
  • The Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. (newswise.com)
  • There were also two confirmed cases of dengue in the months of November and December last year. (radionz.co.nz)
  • But after a new analysis of data from the trials, Sanofi confirmed last month the vaccine could increase the risk of severe dengue in some cases in people who had not been previously exposed to the disease. (reuters.com)
  • There were more than 47,000 cases of dengue reported in the country, a majority of them in the Guangdong province. (ibtimes.com)
  • Singapore reported almost 3,000 dengue cases in the first half of this year, more than twice as many as in the same period last year. (voanews.com)
  • The earlier-than-usual arrival of the rainy season in parts of the region this year is partly to blame for the increase in dengue cases. (voanews.com)
  • There were 4.8 million dengue cases reported to the Pan American Health Organization (PAHO) between 2000 and 2007, compared with 2.7 million in the 1990s and one million in the 1980s. (scidev.net)
  • The pattern of dengue in the Americas is changing, becoming more similar to the Asian profile, with more paediatric cases rather than adult cases,' said Olivia Braithwaite, a researcher at the PAHO Regional Program on Dengue and co-author of the study. (scidev.net)
  • The capital has seen over 1,250 cases of dengue this season, according to data released by the municipal corporations. (deccanherald.com)
  • There has been a steep rise in dengue cases since mid-August. (deccanherald.com)
  • In 2014, the city saw 995 dengue cases in the whole year. (deccanherald.com)
  • The hospital has treated 138 suspected dengue cases in the past one month. (deccanherald.com)
  • There are 57 designated beds for dengue cases. (deccanherald.com)
  • Although the geographic distribution of dengue is similar to that of malaria, dengue is more of a risk in urban and residential areas than is malaria. (cdc.gov)
  • Four key action points were highlighted to advance our understanding of the epidemiology of dengue in Africa. (cdc.gov)
  • Dengue: update on epidemiology. (medscape.com)
  • This article discusses recent advances in dengue research and identifies challenging gaps in research on dengue clinical evaluation, diagnostics, epidemiology, immunology, therapeutics, vaccinology/clinical trials research, vector biology, and vector ecology. (nih.gov)
  • Speculations on future events in the epidemiology, evolution, and biological expression of dengue are presented. (pnas.org)
  • Economic cost of dengue public prevention activities in Puerto Rico. (who.int)
  • The availability of treatment has limited dengue-related fatalities in Puerto Rico, with deaths averaging about 16 per year, the study found. (upi.com)
  • Patients must be monitored carefully for the onset of the severe form of dengue. (cnn.com)
  • Following the 2011 flooding, the province as a whole, which is home to 120 million people, saw more than 21,000 confirmed dengue patients and 359 deaths. (slate.com)
  • Based on WHO criteria for diagnosis of dengue, headache (48/56), retro-orbital pain (30/56), limb pain (51/56) and external bleeding (29/56) showed significant association with dengue. (news-medical.net)
  • Evaluation of the WHO 2009 classification for diagnosis of acute dengue in a large cohort of adults and children in Sri Lanka during a denque-1 epidemic. (umn.edu)
  • Early diagnosis and prompt treatment can substantially reduce the risk of complications from dengue. (babycenter.com)
  • It has also torpedoed initial expectations by analysts and the company that Dengvaxia, the first dengue vaccine to be developed, might become a $1 billion-a-year blockbuster product. (reuters.com)
  • Treatment of acute dengue is supportive and includes giving fluid either by mouth or intravenously for mild or moderate disease. (wikipedia.org)
  • Generally most prevalent in tropical and subtropical areas, dengue made a return to Key West, Fla., in 2009 after being absent since 1934. (go.com)
  • However, as many as 5% of all dengue patients develop severe, life-threatening disease. (cdc.gov)
  • The clinical presentations of dengue disease in adults are not fully described. (who.int)
  • A 24-hour government sponsored online service, the "Punjab Health Line Project For Dengue" provided information about the disease and its prevention. (wikipedia.org)
  • Dengue can have various manifestations in the eye, (10)(11) and more recently a newer terminology of "dengue eye disease" has emerged (12). (bmj.com)
  • Dengue was once prevalent only in Southeast Asia , but as the mosquito vectors have spread, so has the disease. (everything2.com)
  • The Center for Disease Control has a dedicated branch for Dengue should doctors require more information on DHF. (medic8.com)
  • Horstick O, Runge-Ranzinger S. Protection of the house against Chagas disease, dengue, leishmaniasis, and lymphatic filariasis: a systematic review. (umn.edu)
  • Bugs infected with the microbe are unable to spread dengue, a painful disease that infects 390 million people every year. (scientificamerican.com)
  • The Union health ministry has laid down a protocol, as part of the National Vector Borne Disease Control Programme, for surveillance and prevention of dengue and other mosquito-borne diseases. (telegraphindia.com)
  • According to experts, an epidemiological study of dengue calls for recording the pattern of the disease for at least three years. (telegraphindia.com)
  • From the high balcony of a Singapore public housing block, an environment official steadies his mosquito launcher, the latest contraption authorities have devised to combat a record outbreak of the tropical disease dengue. (japantimes.co.jp)
  • Takeda Pharmaceutical Co. said Tuesday that its experimental dengue vaccine appears to be safe and effective at preventing all four types of the mosquito-borne disease, meeting the main goal of the drugmaker's late-stage clinical trial. (japantimes.co.jp)
  • Babies infected with dengue are at higher risk for a severe case of the disease. (babycenter.com)
  • As Australia's dengue season escalates, we look at how science is trying to tackle the rise of this potentially deadly disease. (abc.net.au)
  • The researchers have bred mozzies that contain Wolbachia pipientis , a bacterium which stops them from becoming infected with dengue, eliminating a crucial link in the chain of disease. (abc.net.au)
  • Although dengue is a major global tropical pathogen, epidemiologic and disease control considerations in this article emphasize dengue in the Americas. (nih.gov)
  • On the occasion, Raja Shaukat Mahmood briefed that Wasa was creating awareness among people about the danger of dengue and issued preventive ways to cope with this disease. (com.pk)
  • The ultimate goal for this new vaccine is to rapidly protect against dengue's manifestations with a single dose and to create an effective dengue vaccine for protecting military personnel against this potentially mission-aborting disease. (prweb.com)
  • The study's authors cited two main possibilities: the children had immature immune systems that made the vaccine less protective, or the vaccine itself made them more susceptible to severe disease if they had never had dengue and later became infected. (reuters.com)
  • Their decisions on how the vaccine was rolled out could set back efforts to combat dengue by a generation, some disease experts say. (reuters.com)
  • Four decades ago, Dr. Scott Halstead, a leading figure in dengue research, first proposed that antibodies from an initial exposure to one of four types of the disease could increase the risk of a potentially lethal complication called severe dengue when a person was infected a second time, a process know as antibody-dependent enhancement or ADE. (reuters.com)
  • The increase in case numbers, driven by more frequent movement of goods and people, has serious implications from a global health perspective and poses a threat to countries of the northern hemisphere, especially in Europe, where dengue mostly occurs as an imported disease. (iss.it)
  • Dengue is common in South Asia, especially during the monsoon season which runs from June to September, and there is no specific treatment, but with early detection and access to proper medical care fewer than 1% of sufferers die from the disease. (reuters.com)
  • Dengue is a notable disease in China. (ibtimes.com)
  • It is estimated that dengue kills some 20,000 people around the world each year and so far, no commercially available vaccine or proper treatment is available for the disease. (ibtimes.com)
  • She told SciDev.Net that this may be because, as adults are exposed to several types of dengue, they develop resistance to the disease. (scidev.net)
  • The vaccine was determined to be approximately 76 percent effective in preventing symptomatic, laboratory-confirmed dengue disease in individuals 9 through 16 years of age who previously had laboratory-confirmed dengue disease. (wikipedia.org)
  • Second, representative data need to be collected across Africa to uncover the true burden of dengue. (cdc.gov)
  • The global distribution and burden of dengue. (medscape.com)
  • Nine of 21 samples sent for testing came back positive for dengue. (go.com)
  • Around 2,200 people have tested positive for dengue in the Calcutta municipal area this year. (telegraphindia.com)
  • Till now, 50 people have tested positive for dengue at the hospital," says Dr Mukesh Kumar, who heads the medicine department. (deccanherald.com)