An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.
A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.
A virulent form of dengue characterized by THROMBOCYTOPENIA and an increase in vascular permeability (grades I and II) and distinguished by a positive pain test (e.g., TOURNIQUET PAIN TEST). When accompanied by SHOCK (grades III and IV), it is called dengue shock syndrome.
Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.
A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.
Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
Immunoglobulins produced in response to VIRAL ANTIGENS.
A family of the order DIPTERA that comprises the mosquitoes. The larval stages are aquatic, and the adults can be recognized by the characteristic WINGS, ANIMAL venation, the scales along the wing veins, and the long proboscis. Many species are of particular medical importance.
Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.
Enhancement of viral infectivity caused by non-neutralizing antibodies. There are at least two mechanisms known to account for this: mediation by Fc receptors (RECEPTORS, FC) or by complement receptors (RECEPTORS, COMPLEMENT). Either the virus is complexed with antiviral IMMUNOGLOBULIN G and binds to Fc receptors, or virus is coated with antiviral IMMUNOGLOBULIN M and binds to complement receptors.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
A genus of FLAVIVIRIDAE containing several subgroups and many species. Most are arboviruses transmitted by mosquitoes or ticks. The type species is YELLOW FEVER VIRUS.
The reduction or regulation of the population of mosquitoes through chemical, biological, or other means.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
An island in the Greater Antilles in the West Indies. Its capital is San Juan. It is a self-governing commonwealth in union with the United States. It was discovered by Columbus in 1493 but no colonization was attempted until 1508. It belonged to Spain until ceded to the United States in 1898. It became a commonwealth with autonomy in internal affairs in 1952. Columbus named the island San Juan for St. John's Day, the Monday he arrived, and the bay Puerto Rico, rich harbor. The island became Puerto Rico officially in 1932. (From Webster's New Geographical Dictionary, 1988, p987 & Room, Brewer's Dictionary of Names, 1992, p436)
Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.
Aspects of health and disease related to travel.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Ribonucleic acid that makes up the genetic material of viruses.
The general name for NORTH AMERICA; CENTRAL AMERICA; and SOUTH AMERICA unspecified or combined.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
An island in the Greater Antilles in the West Indies, south of Florida. With the adjacent islands it forms the Republic of Cuba. Its capital is Havana. It was discovered by Columbus on his first voyage in 1492 and conquered by Spain in 1511. It has a varied history under Spain, Great Britain, and the United States but has been independent since 1902. The name Cuba is said to be an Indian name of unknown origin but the language that gave the name is extinct, so the etymology is a conjecture. (From Webster's New Geographical Dictionary, 1988, p302 & Room, Brewer's Dictionary of Names, 1992, p132)
Water particles that fall from the ATMOSPHERE.
Substances elaborated by viruses that have antigenic activity.
The collective name for the islands of the central Pacific Ocean, including the Austral Islands, Cook Islands, Easter Island, HAWAII; NEW ZEALAND; Phoenix Islands, PITCAIRN ISLAND; SAMOA; TONGA; Tuamotu Archipelago, Wake Island, and Wallis and Futuna Islands. Polynesians are of the Caucasoid race, but many are of mixed origin. Polynesia is from the Greek poly, many + nesos, island, with reference to the many islands in the group. (From Webster's New Geographical Dictionary, 1988, p966 & Room, Brewer's Dictionary of Names, 1992, p426)

Scientists try new strategy to eradicate dengue fever.(1/2084)


Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. (2/2084)

T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with <72 h of fever were studied. Plasma levels of 80-kDa soluble tumor necrosis factor receptors (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-gamma and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-alpha was detectable more often in DHF than in DF or OFIs (P<.05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.  (+info)

Variation in oral susceptibility to dengue type 2 virus of populations of Aedes aegypti from the islands of Tahiti and Moorea, French Polynesia. (3/2084)

Twenty three samples of Aedes aegypti populations from the islands of Tahiti and Moorea (French Polynesia) were tested for their oral susceptibility to dengue type 2 virus. The high infection rates obtained suggest that the artificial feeding protocol used was more efficient than those previously described. Statistical analysis of the results allowed us to define two distinct geographic areas on Tahiti with respect to the susceptibility of Ae. aegypti: the east coast, with homogeneous infection rates, and the west coast, with heterogeneous infection rates. No geographic differences could be demonstrated on Moorea. The possible mechanisms of this phenomenon are discussed in connection with recent findings on the variability of susceptibility of Ae. aegypti to insecticides.  (+info)

Serologic evidence for an epizootic dengue virus infecting toque macaques (Macaca sinica) at Polonnaruwa, Sri Lanka. (4/2084)

Dengue is one of the most rapidly emerging diseases in the tropics. Humans are the principal reservoir of dengue viruses. It is unclear if nonhuman primates also serve as a reservoir of human dengue viruses under certain conditions. In this study, a cross-sectional serologic survey was carried out to characterize the pattern of transmission of a recently identified dengue virus among toque macaques in Sri Lanka. The results indicated that an epizootic dengue virus was active among the macaques. A single epizootic had taken place between October 1986 and February 1987 during which 94% of the macaques within the 3 km2 study site were exposed to the virus. The epizootic was highly focal in nature because macaques living 5 km from the study population were not exposed to the virus. The transmission of dengue viruses among macaques in the wild may have important public health implications.  (+info)

Bacterial lipopolysaccharide inhibits dengue virus infection of primary human monocytes/macrophages by blockade of virus entry via a CD14-dependent mechanism. (5/2084)

Monocytes/macrophages (MO/Mphi) are the major target cells for both dengue virus (DV) and bacterial lipopolysaccharide (LPS), and the aim of this study was to define their interactions. We had found that LPS markedly suppressed DV infection of primary human MO/Mphi when it was added to cultures prior to or together with, but not after, viral adsorption. The inhibitory effect of LPS was direct and specific and was not mediated by LPS-induced secretion of cytokines and chemokines such as tumor necrosis factor alpha, interleukin-1beta (IL-1beta), IL-6, IL-8, IL-12, alpha interferon, MIP-1alpha, and RANTES. In fact, productive DV infection was not blocked but was just postponed by LPS, with a time lag equal to one viral replication cycle. Time course studies demonstrated that LPS was only effective in suppressing DV infection of MO/Mphi that had not been previously exposed to the virus. At various time points after viral adsorption, the level of unbound viruses that remained free in the culture supernatants of LPS-pretreated cultures was much higher than that of untreated controls. These observations suggest that the LPS-induced suppression of DV replication was at the level of virus attachment and/or entry. Blockade of the major LPS receptor, CD14, with monoclonal antibodies MY4 or MoS39 failed to inhibit DV infection but could totally abrogate the inhibitory effect of LPS. Moreover, human serum could significantly enhance the LPS-induced DV suppression in a CD14-dependent manner, indicating that the "binding" of LPS to CD14 was critical for the induction of virus inhibition. Taken together, our results suggest that LPS blocked DV entry into human MO/Mphi via its receptor CD14 and that a CD14-associated cell surface structure may be essential for the initiation of a DV infection.  (+info)

A deviation bar chart for detecting dengue outbreaks in Puerto Rico. (6/2084)

OBJECTIVES: A Centers for Disease Control and Prevention deviation bar chart (Statistical Software for Public Health Surveillance) and laboratory-based surveillance data were evaluated for their utility in detecting dengue outbreaks in Puerto Rico. METHODS: A significant increase in dengue incidence was defined as an excess of suspected cases of more than 2 SDs beyond the mean for all 4-week periods from April through June (the period of lowest seasonal incidence), 1989 through 1993. An outbreak was defined as a cumulative annual rate of reported dengue greater than 3 per 1000 population. RESULTS: Retrospective application of the system to 1994 data showed agreement with previous analyses. In 1995 and 1996, 36.4% and 27.3%, respectively, of municipalities with a significant increase in reports for 2 or more consecutive weeks before the first week of September had an outbreak, compared with 9.0% (in 1995, P = .042) and 6.0% (in 1996, P = .054) of towns without a significant increase. The system showed sensitivity near 40%, specificity near 89%, and accuracy in classifying municipalities near 84%. CONCLUSIONS: This method provides a statistically based, visually striking, specific, and timely signal for dengue control efforts.  (+info)

Effects of dengue fever during pregnancy in French Guiana. (7/2084)

To determine the effects of dengue fever (DF) during pregnancy, pregnant women presenting with a dengue-like syndrome at a hospital in Saint-Laurent du Maroni, French Guiana, from 1 January 1992 to 1 April 1998 were studied. The diagnosis of DF was made by serological tests, virus isolation on AP 61 mosquito cells, and/or reverse transcriptase polymerase chain reaction analysis. Twenty-two women had either probable or confirmed DF. Dengue virus serotype 2 was detected in four cases, and dengue virus serotype 1 was detected in one. Three fetuses died following the onset of the disease, and three cases of prematurity occurred. All infants appeared normal during physical examination, and no neonatal DF was diagnosed. In conclusion, DF in pregnant women did not cause any infant abnormality, but it may have been responsible for fetal death. The rate of fetal death associated with DF (13.6%) was much higher than the mean rate for the gynecology unit at the hospital (1.9%). However, these differences were not significant, and consequently these preliminary results need to be confirmed.  (+info)

Evaluation of the MRL diagnostics dengue fever virus IgM capture ELISA and the PanBio Rapid Immunochromatographic Test for diagnosis of dengue fever in Jamaica. (8/2084)

We evaluated two new commercial dengue diagnostic tests, the MRL Diagnostics Dengue Fever Virus IgM Capture ELISA and the PanBio Rapid Immunochromatographic Test, on serum samples collected during a dengue epidemic in Jamaica. The MRL ELISA method correctly identified 98% (78 of 80) of the samples as dengue positive, while the PanBio test identified 100% (80 of 80). Both tests were 100% (20 samples of 20) specific.  (+info)

Symptoms of dengue fever typically begin within 2-7 days after the bite of an infected mosquito and can include:

* High fever
* Severe headache
* Pain behind the eyes
* Severe joint and muscle pain
* Rash
* Fatigue
* Nausea
* Vomiting

In some cases, dengue fever can develop into a more severe form of the disease, known as dengue hemorrhagic fever (DHF), which can be life-threatening. Symptoms of DHF include:

* Severe abdominal pain
* Vomiting
* Diarrhea
* Bleeding from the nose, gums, or under the skin
* Easy bruising
* Petechiae (small red spots on the skin)
* Black stools
* Decreased urine output

Dengue fever is diagnosed based on a combination of symptoms, physical examination findings, and laboratory tests. Treatment for dengue fever is primarily focused on relieving symptoms and managing fluid and electrolyte imbalances. There is no specific treatment for the virus itself, but early detection and proper medical care can significantly lower the risk of complications and death.

Prevention of dengue fever relies on measures to prevent mosquito bites, such as using insect repellents, wearing protective clothing, and eliminating standing water around homes and communities to reduce the breeding of mosquitoes. Vaccines against dengue fever are also being developed, but none are currently available for widespread use.

In summary, dengue is a viral disease that is transmitted to humans through the bite of infected mosquitoes and can cause a range of symptoms from mild to severe. Early detection and proper medical care are essential to prevent complications and death from dengue fever. Prevention of dengue relies on measures to prevent mosquito bites and eliminating standing water around homes and communities.


1. World Health Organization. (2020). Dengue and severe dengue. Retrieved from
2. Centers for Disease Control and Prevention. (2020). Dengue fever: Background. Retrieved from
3. Mayo Clinic. (2020). Dengue fever. Retrieved from
4. MedlinePlus. (2020). Dengue fever. Retrieved from

* High fever that lasts for more than 2 days
* Severe headache, muscle and joint pain, and rash
* Nausea, vomiting, diarrhea, and abdominal pain
* Bleeding from the gastrointestinal tract, nose, or gums
* Decreased urine output or no urine output for more than 6 hours
* Rapid heart rate (more than 120 beats per minute)
* Low blood platelet count (less than 50,000 cells/mm3)
* Serious complications such as hemorrhagic shock, acute respiratory distress syndrome, or multi-organ failure

Severe dengue is a medical emergency and requires immediate hospitalization and careful monitoring. Treatment includes fluid replacement therapy, pain management, and supportive care to prevent complications.

The 1997 classification divided dengue into an undifferentiated fever, dengue fever, and dengue hemorrhagic fever. Dengue ... Shock (dengue shock syndrome) and hemorrhage (dengue hemorrhagic fever) occur in less than 5% of all cases of dengue; however, ... "Marking ASEAN Dengue Day". Archived from the original on 17 June 2015. Retrieved 16 June 2015. ACTION AGAINST DENGUE Dengue Day ... "Dengue and severe dengue". Retrieved 15 December 2019. Noble CG, Chen YL, Dong H, Gu F, Lim SP, Schul W, Wang QY, ...
... is a vaccine used to prevent dengue fever in humans. Development of dengue vaccines began in the 1920s, but was ... "Takeda's QDENGA®▼ (Dengue Tetravalent Vaccine [Live, Attenuated]) Approved in Indonesia for Use Regardless of Prior Dengue ... "Dengue Vaccines". Drug Information Portal. U.S. National Library of Medicine. Dengue vaccine research. World Health ... "Takeda Begins Regulatory Submissions for Dengue Vaccine Candidate in EU and Dengue-Endemic Countries" (Press release). Osaka, ...
Common names for dengue fever include breakbone fever, vomiting and dandy fever; dengue hemorrhagic fever and dengue shock ... dengue shock syndrome). A common problem faced in dengue-endemic regions is when mothers become infected with dengue; after ... Dengue virus (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family ... Scholia has a topic profile for Dengue virus. 3D electron microscopy structures of dengue virus from the EM Data Bank(EMDB) " ...
... official website Dengue Dengue Dengue! at AllMusic Live session of Dengue Dengue Dengue on (CS1 ... "Dengue Dengue Dengue!". Retrieved 2022-08-04. "Hay que conocerlos: Dengue Dengue Dengue". Red Bull ... "Dengue Dengue Dengue: Dimensiones del virus". Peru21 (in Spanish). 2018-04-02. Retrieved 2022-04-13. "Dengue Dengue Dengue ... Dengue Dengue Dengue". Fact Magazine. 2021-01-05. Retrieved 2022-04-14. "Watch Peruvian Audiovisual Duo Dengue Dengue Dengue at ...
"Dengue Fever (2003) album". AllMusic. "Dengue Fever: Artist Biography". Retrieved 1 February 2018. "Dengue Fever: 'Escape from ... In 2017, Dengue Fever embarked on their longest-ever American tour as the support act for Tinariwen. In 2018, Dengue Fever ... Dengue Fever (2003) Dengue Fever (EP, 2005) Escape from Dragon House (2005) Sip Off the Mekong (EP, 2006) Venus On Earth (2008 ... "Dengue Fever". AllMusic. Retrieved October 23, 2016. "Psychedelic Cambodian surf band Dengue Fever to visit Bay". San Francisco ...
Dengue Fever Hits Paraguay Reuters, "Dengue Fever Hits Paraguay", New York Times" (March 4, 2007)] "Dengue Fever Outbreak ... Significant outbreaks of dengue fever tend to occur every five or six months. The cyclical rise and fall in numbers of dengue ... Epidemic dengue has become more common since the 1980s. By the late 1990s, dengue was the most important mosquito-borne disease ... "Dengue fever cases hit a high in parts of Southeast Asia -media". Retrieved 20 September 2015. "DOH: 42,207 dengue ...
Dengue fever may also refer to: Dengue virus, the virus that causes dengue fever Dengue Fever (band) Dengue fever outbreaks ... Dengue fever is an endemic viral infectious disease. ... page lists articles associated with the title Dengue fever. If ...
"World Community Grid - Research - Discovering Dengue Drugs - Together". World Community Grid. "Discovering Dengue Drugs - ... Discovering Dengue Drugs - Together (DDDT) was a World Community Grid project launched in 2007 sponsored by scientists at the ... "Discovering Dengue Drugs Together project slowed down because of hurricane". World Community Grid ("Known Issues" forum posting ... Drug candidates that make it through Phase 2 were lab-tested, and in 2014, a novel small-molecule inhibitor of dengue virus ...
1 of 20 individuals who become ill with dengue will develop severe dengue. Severe dengue can lead to life-threatening condition ... The 2009 Bolivian dengue fever epidemic was an epidemic of dengue fever which struck Bolivia in early 2009, escalating into a ... Dengue fever at the BBC Dengue fever at the Centers for Disease Control and Prevention Pan American Health Organisation (2009 ... There is no specific treatment for dengue, other than managing the symptoms. The best way to address dengue is to disrupt the ...
... - official website for Campaign Against Dengue Dengue Hotspots - Ministry of Health Dengue Prevention ... "Dengue cases down for 4th week in a row". TODAY. 29 July 2013. Ng, Keng Gene (14 October 2020). "28 people have died of dengue ... In the 2005 dengue outbreak in Singapore, a significant rise in the number of dengue fever cases was reported in Singapore, ... An inter-agency Dengue Coordination Committee and a community-centred Dengue Watch Committee have also been established. The ...
2006 dengue outbreak in Pakistan Dengue fever More dengue, chikungunya cases reported, NDTV Web Version, Accessed 9 October ... In the 2006 dengue outbreak in India, cases of dengue fever were reported first from New Delhi in early September and by the ... Highest no of dengue deaths in Delhi today, Hindustan Times. Accessed: October 13 AIIMS student dies of dengue in Delhi, Daily ... Nationwide data on the dengue outbreak, released by the Ministry of Health On 13 October 2006, six persons died due to dengue ...
The 2019 dengue outbreak in Bangladesh is a nationwide occurrence of dengue fever in Bangladesh that began primarily in April ... In August 2019, Bangladesh Governments withdraws all tariffs on dengue test kits imports. Dengue fever was first observed in ... Dengue fever outbreaks Mosquito control ১১ মাস পর ডেঙ্গুহীন হাসপাতাল. (in Bengali). Dhaka. 2020-02-28. Retrieved ... According to official source, roughly 71 more people are being infected in dengue fever every hour. Dhaka is the worst-hit city ...
In the 2015 dengue outbreak in Taiwan, a significant rise in the number of dengue fever cases was reported in Tainan City, ... Tainan City Government Dengue Epidemic Bulletin Department of Health of Tainan's Dengue Epidemic Bulletin v t e (Articles with ... "CECC for Dengue Outbreak announces new deaths associated with dengue and urges public to reinforce cleaning and emptying of ... The average number of days between onset and death is 6.2." The same press release as above states: "Currently, 44 dengue ...
The Dengue pandemic in Sri Lanka is part of the tropical disease Dengue fever pandemic. Dengue fever caused by Dengue virus. ... From 1989 onward, Dengue fever has become endemic in Sri Lanka. Dengue outbreak start Sri Lanka since 1960s, Ministry of Health ... In 1990 dengue cases rise 1,350 of54 deaths. Early 90s, annually dengue cases reported up to 1,000. In 2002 recorded the ... Historical Account of Dengue Haemorrhagic Fever in Sri Lanka (1997). "Historical of Dengue Fever in Sri Lanka" (PDF). World ...
2006 dengue outbreak in India 2011 dengue outbreak in Pakistan Mosquito control Ghani, MH (May-August 2008). "Dengue virus ... The 2006 dengue outbreak in Pakistan was at the time the worst on record. There were 1931 lab-confirmed cases, and 41 confirmed ... Since 2006, studies indicate that dengue fever is on the rise in Pakistan. It is noted throughout the year, peaking at post- ... 6 (37): 1. Rasheed, SB (January 2013). "A review of dengue as an emerging disease in Pakistan". Public Health. 127 (1): 11-17. ...
In the 2017 dengue outbreak in Peshawar, Pakistan, hundreds of incidents of dengue fever were reported in Peshawar in mid-2017 ... "Dengue experts to stay in Peshawar". 21 August 2017. "Punjab dengue experts leave for Peshawar". " ... 2011 dengue outbreak in Pakistan "Emergency meeting called over Peshawar dengue outbreak". 19 August 2017. " ... "Pakistan: Dengue Outbreak - Sep 2017". WHO. 16 December 2019. Retrieved 15 May 2020. (2017 in Pakistan, Dengue ...
2011 dengue outbreak in Pakistan 2017 dengue outbreak in Peshawar "WHO EMRO , Outbreak update - Dengue in Pakistan, 1 December ... "Dengue cases surpass all-time record in the country". Dawn. October 15, 2019. "Official says deadly dengue outbreak in Pakistan ... "PM Imran takes strict notice of dengue outbreak". Dunya News. 1 October 2019. "PHC summons health secy over dengue outbreak". ... In Pakistan, in the summer of 2019, more than 47 people have died and more than 30,000 have been infected by Dengue fever. In ...
"Dengue death toll rises to 31; over 5,000 infected". DAWN.COM. 2010-11-04. Retrieved 2022-08-17. "Vicious dengue continues ... 2017 dengue outbreak in Peshawar Pakistan portal "Why Pakistan Is Having The Dengue Epidemic Every Summer?" Medicalopedia 19 ... "Seven more succumb to dengue in city." Accessed 12 May 2013. "Pakistan hit by Dengue fever outbreak." Archived 2011-12 ... A special tribunal for Dengue fever was empanelled. The chairman of the Dengue Emergency Response Committee was Khawaja Saad ...
2019 dengue outbreak in Bangladesh 2019 dengue outbreak in Pakistan "Philippines declares epidemic after dengue fever kills ... revealed the appearance of autochthonous dengue in Europe along with the increase in imported dengue and dengue severity. ... "Casos de dengue". OPS/OMS. Archived from the original on 2020-03-26. Retrieved 2020-03-26. "Casos y muertes dengue grave". OPS/ ... The 2019-2020 dengue fever epidemic was an epidemic of the infectious disease dengue fever in several countries of Southeast ...
Dengue fever outbreaks (worldwide) Ng, Jun Sen (11 February 2020). "Dengue cases at four-year high". today. the dengue outbreak ... In the 2013 dengue outbreak in Singapore, a significant rise in the number of dengue fever cases was reported in Singapore. The ... "Dengue cases down for 4th week in a row". TODAY. 29 July 2013. "Singapore's dengue cases reach a record 22,403, surpassing 2013 ... "Number of dengue cases weekly hits 5-year high". today. 16 February 2013. "Number of dengue cases hits new high". today. 16 ...
In the 2020 dengue outbreak in Singapore, a record-breaking number of dengue fever cases was reported in Singapore. This was ... "Dengue Cases Expected To Exceed Last Year's 16,000 Cases Unless All Stakeholders Take Immediate Concerted Action Against Dengue ... The year ended with a total of 35,315 dengue fever cases, including 54 instances of dengue haemorrhagic fever, a more severe ... "Dengue surveillance data, Jan - Mar 2020" (PDF). National Environment Agency. "Dengue surveillance data, Apr - Jun 2020" (PDF ...
The Cook Islands Dengue Fever Outbreak refers to the Dengue fever outbreak in the Cook Islands beginning sometime in January ... "Dengue update 27 February 2019 - Cook Islands". ReliefWeb. Retrieved 20 May 2019. "Cook Islands declare dengue outbreak in ... "Dengue-1 Outbreak in the Cook Islands: Situation Report 10: ending 12 March 2020 - Reporting Date: 13 March 2020". ReliefWeb. ... This was relatively new, as the last dengue fever outbreak was in 2009; this specific serotype of DENV-1 in 2007. Initial cases ...
In the 2017 dengue epidemic in Sri Lanka, a rise in the number of dengue fever cases was reported on the island country of Sri ... "Dengue and severe dengue". Retrieved 2022-10-28. Guha-Sapir, Debarati; van Panhuis, Willem Gijsbert (December 2009 ... Dengue treatment strained national economic resources costing Sri Lanka US $12.7 million (LKR 1.938 billion). Today dengue ... Dengue fever - Sri Lanka". WHO. Archived from the original on July 21, 2017. Retrieved 2020-11-27. "Sri Lanka: Dengue Outbreak ...
NSAIDs may increase the risk of bleeding in patients with Dengue fever For this reason, NSAIDs are only available with a ... "Dengue". United States Centers for Disease Control and Prevention. 28 March 2016. Retrieved 27 April 2018. Use acetaminophen. ...
Aspirin and ibuprofen should not be taken in cases of dengue fever as it could increase the risk of bleeding and cause Dengue ... Gubler, D. J. (1998). "Dengue and dengue hemorrhagic fever". Clinical Microbiology Reviews. 11 (3): 480-496. doi:10.1128/CMR. ... Genus Flavivirus Mosquito-borne viruses Dengue virus group Dengue virus Japanese encephalitis virus group Japanese encephalitis ... Tambyah, P. A.; Koay, E. S. C.; Poon, M. L. M.; Lin, R. V. T. P.; Ong, B. K. C.; Transfusion-Transmitted Dengue Infection Study ...
Therefore, its use as a diagnostic test for dengue is questioned as people who have a negative test may still have dengue. It ... 2011). "Predictive diagnostic value of the tourniquet test for the diagnosis of dengue infection in adults". Trop Med Int ... 2006). "Repeated tourniquet testing as a diagnostic tool in dengue infection". Med J Malaysia. 61: 22-7. (Physical examination ... Hess test WHO (2009). Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control (PDF). ISBN 978-92-4-154787-1. " ...
He also highlighted the importance of dengue, a related mosquito-borne virus, as a cause of neurological disease. He works on ... Dengue. In: Nath A, Berger J, editors. Clinical Neurovirology. Marcel Decker, New York NY. pp. 469-516. "Scientist wins pounds ... "Neurological manifestations of dengue infection". The Lancet. 355 (9209): 1053-1059. doi:10.1016/S0140-6736(00)02036-5. PMID ...
Wilder-Smith, Annelies; Ooi, Eng-Eong; Horstick, Olaf; Wills, Bridget (January 2019). "Dengue". The Lancet. 393 (10169): 350- ...
Halstead, Scott B. (2009-03-31). Dengue. Imperial College Press. ISBN 9781848162297. Retrieved 2012-05-20. Jules Dubos, René; ...
"Dengue Vaccine Registered in 18 Countries". Sanofi Pasteur. Retrieved 2 February 2018.[self-published source] ... "Pharma firm issues caution on use of anti-dengue vaccine". Retrieved 2 April 2018. "DOH suspends dengue ... The victims' parents blamed the dengue vaccine for the deaths of their children. In July 2020, Sanofi Pasteur announced that it ... Dengue vaccines Dengvaxia, approved in 18 countries DPT vaccines Adacel Daptacel Tripedia (Trepedia), discontinued, last ...
Almost half of the worlds population, about 4 billion people, live in areas with a risk of dengue. Dengue is often a leading ... Dengue viruses are spread to people through the bite of an infected Aedes species mosquito. ... Dengue Vaccineplus icon*For Healthcare Providers: A Dengue Vaccine Can Protect Your Patientsplus icon*Vaccine Eligibility & ... About Dengue. *Dengue viruses are spread to people through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus ...
View MoreMeSH SubjectSevere Dengue (‎206)‎Dengue (‎18)‎Dengue Virus (‎1)‎Date Issued2010 - 2020 (‎32)‎2000 - 2009 (‎324)‎1990 ... The endemicity of dengue fever and dengue haemorrhagic fever (‎DHF)‎ in countries of the South-East Asia (‎SEA)‎ and the ... Dengue Bulletin.The objective of the Bulletin is to disseminate updated information on thecurrent status of dengue fever/dengue ... has been jointly publishing the annual Dengue Bulletin. The Dengue Bulletin accepts research papers on aspects related to ... ...
Classical dengue with rash after appropriate incubation in first and subsequent volunteers and Ae aegypti transmission.** ...
... s Dengue Branch. Clinicians can obtain consultation on dengue diagnostic testing from CDC at 787-706-2399 or by emailing dengue ... Dengue in Pregnancy. Data are limited on health outcomes of dengue in pregnancy and effects of maternal infection on the ... Phases of Symptomatic Dengue. Febrile Phase. Symptomatic dengue begins abruptly after an incubation period of 5-7 days (range 3 ... Symptomatic dengue most commonly presents as a mild to moderate, nonspecific, acute febrile illness; ≤5% of all dengue patients ...
Dengue is an infection caused by a virus. You can get it if an infected mosquito bites you. Learn more about risk and ... Dengue (Centers for Disease Control and Prevention) Also in Spanish * Dengue and Severe Dengue (World Health Organization) Also ... Severe dengue often requires care at a hospital.. Can dengue be prevented?. There is a vaccine to prevent dengue. It is ... Severe dengue is a serious form of the illness. About 1 in 20 people who get sick with dengue will develop severe dengue. It ...
2016)‎. Dengue. Bureau régional de lOMS pour le Pacifique occidental. ...
Dengue is the most common arthropod-borne viral (arboviral) illness in humans. Globally, 2. ... Dengue vaccine was approved in the United States by the FDA in 2019 for prevention of dengue disease caused by dengue virus ... Dengue and Severe Dengue. WHO. Available at March 17 ... Bed rest is recommended for patients with symptomatic dengue fever, dengue hemorrhagic fever, or dengue shock syndrome. Permit ...
Dengue is a systemic viral infection transmitted between humans by Aedes mosquitoes1. For some patients, dengue is a life- ... The incidence of dengue is on the increase, but the current global distribution is poorly known. Simon Hay and colleagues have ... We predict dengue to be ubiquitous throughout the tropics, with local spatial variations in risk influenced strongly by ... The contemporary worldwide distribution of the risk of dengue virus infection4 and its public health burden are poorly known2,5 ...
World Distribution of Dengue. Aedes Aegypti Distribution in the Americas. INTRODUCTION. Dengue and dengue hemorrhagic fever ( ... Why dengue hemorrhagic fever in Cuba? * Individual risk factors for dengue hemorrhagic fever/dengue shock syndrome. Trans R Soc ... Dengue and Dengue Hemorrhagic Fever Dengue Branch and the Division of Vector Borne Infectious Diseases, Centers for Disease ... Dengue and dengue hemorrhagic fever in the Americas. In: Thongcharoen P, ed. Dengue hemorrhagic fever. WHO Monograph. New Delhi ...
... dengue - Sharing our stories on preparing for and responding to public health events ... Tags dengue, disease, EIS, fever, Marshall Islands, mosquito Dengue: The Key West Tour. I often get asked about mosquito-borne ... Tags CDC, dengue, fever, Florida, key west, mosquito, Texas The Reality of Outbreak Investigations: Dengue in Angola. By Tyler ... Tags africa, dengue, mosquitoes Coming (Back) to America? What 2013 Can Teach Us About Dengue in the United States. By Tyler ...
Dengue fever is an arbovirus transmitted by Aedes mosquitoes. ... Dengue and severe dengue. Dengue vaccine: WHO position paper - ... Severe dengue (also known as Dengue Haemorrhagic Fever) was first recognized in the 1950s during dengue epidemics in the ... Global burden of dengue The incidence of dengue has grown dramatically around the world in recent decades. The actual numbers ... Dengue is a mosquito-borne viral disease that has rapidly spread in all regions of WHO in recent years. Dengue virus is ...
Dengue. Click to expandDengue is a mosquito-borne viral disease that is transmitted between humans by Aedes mosquitoes. The ... Reports of dengue and severe dengue epidemics in the Region started in 1998 and have increased in frequency and spread ever ... Serological evidence of circulation of dengue fever has also been reported from Jordan. All the 4 serotypes of dengue virus ... Once infection has occurred, there is no specific treatment for dengue fever, although for severe dengue early detection and ...
Dengue fever) has become a raging problem," said Fuller. "The number of cases is out of control in many parts of Latin America ... Dengue fever cases have surged in recent years and are only now beginning to level out as health officials become more aware of ... Symptoms for dengue include a severe headache, muscle and joint pains, fever and a bright red rash. Malaria is characterized by ... According to numbers released in May by the Health Ministry, the number of dengue fever cases in Costa Rica dropped by 46.7 ...
Dengue fever in New Caledonia. Author Yann MeunierPublished on May 5, 2010. January 12, 2018. ... An epidemic of hemorrhagic dengue fever has struck the New Caledonia archipelago. People are dying at the Gaston Bourret ...
Describe current dengue epidemiology and the populations who are at greatest risk for dengue and severe dengue in the United ... dengue, dengue with warning signs, severe dengue) based on a patients clinical and laboratory findings. ... What Clinicians Need to Know about Dengue in the United States. *Evaluating and Supporting Patients Presenting with ... During this COCA Call, presenters will discuss the current global and domestic dengue epidemiology and its relevance for ...
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Bangkok - Up to 10,446 cases of dengue fever infection have been recorded in Thailand since January 1 of this year with 15 ... An estimated 74,000 to 75,000 people are expected to contract dengue this year and more deaths are likely now that infection ... The actions protect against dengue, the Zika virus and other mosquito borne infections. Information can be found by contacting ... Suwanchai Wattanayingcharoenchai, elaborated that most cases of dengue infection were among citizens aged between 15 and 24, ...
Dengue is the most common arthropod-borne viral (arboviral) illness in humans. Globally, 2. ... Severe dengue (dengue hemorrhagic fever). Severe dengue occurs less frequently than dengue fever but has a more dramatic ... Dengue virus transmission follows 2 general patterns: epidemic dengue and hyperendemic dengue. Epidemic dengue transmission ... Severe dengue (dengue hemorrhagic fever/dengue shock syndrome) usually occur around the third to seventh day of illness during ...
... the mosquito species that transmits yellow fever and dengue fever, has arrived in California. ... Dengue fever too is hemorrhagic, characterized by severe headache, pain, and bleeding, according to the CDC. Neither fever has ... The possibility for disease transmission still exists, albeit a small one, as cases of dengue and yellow fever are incredibly ... Since 2010, 200 people in California have been diagnosed with dengue fever, all of whom were infected while travelling outside ...
"Dengue needs urgent action and we need it now. In the absence of the usual cures and vaccines, we have to rely on the basics of ... "The battle against dengue can be won right in our own backyards but this will not be easy for each one of us," said Ona, ... DOH advises public to practice 4 oclock habit versus dengue. By: Jocelyn R. Uy - Reporter / @mj_uyINQ ... Health Secretary Enrique Ona, who made the call to mark the third year of the Asean Dengue Day on Saturday, said the habit is ...
CHOLOMA, Honduras - More than 400 people died this year as one of the worst dengue epidemics on record swept through Central ... Climate Change and Chaos: A Deadly Mix in Honduras Dengue Epidemic "Rising temperatures are increasing the range of disease- ... In Honduras, which accounted for more than 40 percent of the dengue deaths in Central America this year, according to the Pan ... "CHOLOMA, Honduras - More than 400 people died this year as one of the worst dengue epidemics on record swept through Central ...
... s vaccine candidate to treat dengue has a safe technological platform, as informed by the Center for Genetic Engineering and ... Obtaining the vaccine is a complex process, because dengue has four serotypes and it is necessary to immunize against each of ... Havana, Mar 21 (Prensa Latina) Cuba´s vaccine candidate to treat dengue has a safe technological platform, as informed by the ... Whether infection level by the dengue virus - that is, the viral load - is lowered, severity is avoided; even symptomatology. ...
join the dengue fever family. Be the first to get new tour dates and new music news ... DENGUE FEVER Updates. Get the latest updates on TING MONG and tour dates! ... All images and text © 2002-2023 Dengue Fever. All rights reserved. Website by Luckae. ...
Dengue is the most rapidly spreading mosquito-borne disease in the world with more than 50 million cases globally every year, ... Dengue fever infections dropped dramatically in an Indonesian study where a bacteria was introduced into disease-carrying ... Results of the three-year study, published in the New England Journal of Medicine this week, found that infecting dengue- ... Wolbachia suppresses the ability of the virus to replicate in dengue-carrying Aedes aegypti mosquitoes and cause infections ...
One of the challenges of dengue infection is that it can be caused by one of four versions - or serotypes - of the virus, which ... Innovative Research Model Sheds Light on Immune Response in Dengue Infection March 28, 2019 by Sean Diehl, Ph.D., and Jennifer ... Like Zika, yellow fever and West Nile viruses, dengue belongs to a group of mosquito-borne viruses that circulate in many ... However, without effective treatment and a safe licensed vaccine, dengue infection can lead to debilitating illnesses, ...
Anti NS1 of dengue virus - Research Grade Biosimilar. CATALOG NUMBER: 21-863 ...
... , discussed in the Culebra Forum, Puerto Rico ... Dengue is very real and a horrific virus. 5 out of 7 of my ... Another issue on my mind is some idea of the true frequency of Dengue Fever on Culebra. Often people have these experiences but ... A short time before I found your response I had decided to search Google under "first-hand experience with Dengue Fever." ... It is my understanding that an epidemic of Dengue Fever in Puerto Rico has only recently ended. Apparently Culebra experienced ...
Most people are aware of the spread of the mosquito-borne viral disease, Zika, in many countries in South and Central America. Worldwide, the most important disease transmitted by mosquitos is malaria. Instead of being caused by a virus, however, malaria is caused by a parasite that infects the Anopheles mosquito….. ...
  • Neurological Complications of Dengue Fever. (
  • The endemicity of dengue fever and dengue haemorrhagic fever (‎DHF)‎ in countries of the South-East Asia (‎SEA)‎ and the Western Pacific regions continues to rise. (
  • The disease dengue fever transmitting the virus to a new host while blood feeding. (
  • During epidemics of dengue, attack rates may be bone fever, dandy fever, and 80%-90% in susceptible persons. (
  • Dengue fever is a short-dura- and are unaware of their situation. (
  • More than 2 billion of the dengue hemorrhagic fever (DHF) and dengue shock syn- approximately 6.5 billion inhabitants of this planet are at drome, so that having uncomplicated DF can presage hav- risk of acquiring dengue, and the World Health ing DHF (1). (
  • DHF is characterized by high fever, vascular perme- cases of dengue infection worldwide every year" (avail- ability, bleeding, enlargement of the liver, and circulatory able from failure (dengue shock syndrome). (
  • Either there cases, signs and symptoms subside after the fever subsides, are 50 million dengue infections (some with illness, some but in severe cases the patient's condition suddenly deteri- not) or there are 50 million people sick with dengue each orates, body temperature decreases, and the circulatory year. (
  • Dengue fever usually starts with a fever, joint pain, rash and nausea. (
  • Without treatment, the virus can cause damage to blood and lymph vessels and lead to dengue hemorrhagic fever, which is marked by difficulty breathing, bruising and bleeding from the nose, gums or under the skin. (
  • Dengue fever usually is a self-limited illness. (
  • There is no specific antiviral treatment available for dengue fever. (
  • Patients with known or suspected dengue fever should have their platelet count and hematocrit measured daily from the third day of illness until 1-2 days after defervescence. (
  • Patients who develop signs of dengue hemorrhagic fever warrant closer observation. (
  • Exercise caution when placing intravascular catheters because of the increased bleeding complications of dengue hemorrhagic fever. (
  • Dengue and dengue hemorrhagic fever (DHF) result from infection by any of four serotypes of dengue viruses. (
  • An outbreak of dengue fever on a small island chain in the middle of the Pacific. (
  • I often get asked about mosquito-borne dengue fever in the context of climate change. (
  • Dengue fever is an arbovirus transmitted by Aedes mosquitoes (both Ae . (
  • Dengue haemorrhagic fever (DHF) is a potentially deadly complication that has become a leading cause of hospitalization and death among children in Asia. (
  • There is no specific treatment for dengue, but appropriate medical care frequently saves the lives of patients with dengue haemorrhagic fever. (
  • mosquito, one of the primary vectors for the transmission of dengue fever around the world. (
  • Serological evidence of circulation of dengue fever has also been reported from Jordan. (
  • Dengue is a mosquito-transmitted acute disease caused by any of four virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4) and is characterized by acute manifestations that can include fever, headache, myalgia, arthralgia, rash, nausea, and vomiting (1). (
  • On August 25, 1995, public health authorities in Mexico notified the Texas Department of Health (TDH) of an ongoing outbreak of dengue fever in the state of Tamaulipas, which borders south Texas ( Figure_1 ). (
  • Dengue hemorrhagic fever (DHF) * was reported in 37 (1%) of these cases. (
  • This syndrome is termed severe dengue (also known as dengue hemorrhagic fever and dengue shock syndrome). (
  • Dengue fever typically is a self-limited disease with a mortality rate of less than 1% when detected early and with access to proper medical care. (
  • Dengue should be suspected in individuals who present with high fever (104°F/40°C), retro-orbital headache, muscle and joint pain, nausea, lymphadenopathy, vomiting, and rash and who have traveled within 2 weeks of symptom onset to an area where appropriate vectors are present and dengue transmission may be occurring. (
  • The initial phase of severe dengue is similar to that of dengue fever and other febrile viral illnesses. (
  • Dengue : breakbone fever : a major unpublicized killer disease / Stephen Whitehead and Anna Durbin. (
  • They were [each and every one of them] diagnosed with Dengue Fever. (
  • Dengue fever is passed on only by a particlular mosquito. (
  • I read an article somewhere that showed the statistics on Dengue fever. (
  • Dengue fever is present in Belize, but it is fairly uncommon compared with most of the rest of Central America. (
  • Dengue can cause hemorrhagic fever and infects an estimated 100 to 400 million people a year, although over 80 percent of cases are mild or asymptomatic, according to the World Health Organization. (
  • But neither option is yet close to eradicating dengue, and Aedes aegypti mosquitoes carry other diseases, including zika and yellow fever. (
  • Each year an estimated 390 million people worldwide are infected with dengue fever. (
  • It was more effective - 88.5 percent - in preventing the more severe and lethal form of dengue, known as hemorrhagic fever. (
  • In China's Yunnan province, a total of 102 cases of dengue fever have been reported. (
  • A scientist has confirmed that Cuba is testing a recombinant vaccine against dengue fever on animals. (
  • Health officials in Guwahati, Assam, are reporting a new outbreak of dengue fever, which has so far claimed three lives over the last eight days while many more have been hospitalized. (
  • Colombian authorities expressed concerns on Monday that the spread of dengue fever could become an epidemic in the rural regions along its borders. (
  • We raised the possibility of signing a bilateral agreement [with Ecuador] that lets us conduct activities together in order to confront dengue fever in the rural border areas, and carry out activities of education, prevention, diagnostics, and treatment. (
  • The most recent report from the National Health Institute in Colombia shows that in the last year, eighteen people have died and another 15,000 have been infected by dengue fever in the country. (
  • A state of emergency was declared in Cali several weeks ago after an outbreak of dengue fever killed at least nine people there. (
  • Dengue fever is a mosquito-born, life-threatening disease similar to malaria, which occurs widely in tropical regions of the world. (
  • The WHO estimate that dengue fever is "now endemic in more than 100 countries. (
  • An epidemic of hemorrhagic dengue fever has struck the New Caledonia archipelago. (
  • Genetically engineered mosquitoes developed by British biotech firm Oxitec as an approach to controlling dengue fever have been caught up in controversy since 6,000 of them were deliberately released to an uninhabited forest in Malaysia in a trial in December 2010. (
  • About two-fifths of the world's population are at risk of contracting dengue fever. (
  • Dr. Suresh Singh Naruka, senior consultant (ENT), Indraprastha Apollo Hospitals, who is leading the treatment of the patient, said, 'A rare case of black fungus (mucormycosis) came into our view when the patient came to the hospital, reporting a sudden loss of vision in one eye post dengue fever. (
  • Dengue is accompanied with high fever and therefore, doctors feel that people might suspect that they have contracted COVID-19. (
  • Bangkok - Up to 10,446 cases of dengue fever infection have been recorded in Thailand since January 1 of this year with 15 deaths so far. (
  • Aedes aegypti, a particularly aggressive mosquito, known for carrying dengue and yellow fever, is spotted in California. (
  • Aedes aegypti, the species of mosquito that transmits deadly tropical diseases including yellow fever and the dengue virus, has made its way through California's Central Valley to the Bay Area this year. (
  • MANILA, Philippines-The Department of Health (DOH) on Friday urged the public to practice what it called the "4 o'clock habit" to help bring down cases of the deadly dengue fever, which is expected to surge during the rainy season. (
  • According to the DOH, efforts were in place to bring down cases of dengue in the country but Visayas and Mindanao should brace for a higher number of cases this year, especially in August and September, when the dengue fever peaks. (
  • Immunochemistry of the dengue viruses, 199-219 In: D. J. Gubler and G. Kuno (eds), Dengue and dengue hemorrhagic fever. (
  • Dengue fever infections dropped dramatically in an Indonesian study where a bacteria was introduced into disease-carrying mosquitoes, offering hope in the battle against an illness that sickens millions annually around the world. (
  • Like Zika, yellow fever and West Nile viruses, dengue belongs to a group of mosquito-borne viruses that circulate in many tropical countries. (
  • However, without effective treatment and a safe licensed vaccine, dengue infection can lead to debilitating illnesses, including severe pain and hemorrhagic fever. (
  • 2001, 600,000 cases of dengue were reported in the ample time for mosquitoes, often many mosquitoes, to Americas, of which 15,000 were cases of DHF, more than feed and become infected. (
  • I traveled there to assist the RMI Ministry of Health and Human Services vector staff in spraying larvicides and adulticides against mosquitoes around dengue cases in Majuro. (
  • The virus that causes dengue is transmitted by mosquitoes. (
  • Infected humans are the main carriers and multipliers of the virus, serving a source of the virus for uninfected Aedes aegypti mosquitoes which maintain the urban dengue transmission cycle. (
  • At present, the only method of controlling or preventing dengue virus transmission is to combat the vector mosquitoes using environmental management and chemical methods. (
  • Click to expand Dengue is a mosquito-borne viral disease that is transmitted between humans by Aedes mosquitoes. (
  • Mosquitoes that transmit dengue and other viruses have evolved growing resistance to insecticides in parts of Asia, and novel ways to control them are desperately needed, new research warns. (
  • Several dengue vaccines have been developed, and researchers have also used a bacteria that sterilises mosquitoes to tackle the virus. (
  • When the clock strikes 4 p.m., assigned teams must "look" for the breeding sites of dengue-carrying mosquitoes and carry out systematic "search and destroy activities to eliminate them. (
  • But while climate change is threatening to increase the spread of dengue worldwide by expanding the range of the mosquitoes that carry the virus, the disease has already found an especially fertile breeding ground in Honduras, for reasons that go beyond the environment. (
  • Results of the three-year study, published in the New England Journal of Medicine this week, found that infecting dengue-carrying mosquitoes with a harmless bacteria called Wolbachia led to a 77 percent drop in human cases. (
  • Wolbachia suppresses the ability of the virus to replicate in dengue-carrying Aedes aegypti mosquitoes and cause infections when they bite humans. (
  • Almost half of the world's population, about 4 billion people, live in areas with a risk of dengue . (
  • Of primary concern is the risk of dengue transmission within the continental United States. (
  • Approximately 100 million people get sick from infection, and 40,000 die from severe dengue. (
  • NIAID-supported investigators are pursuing several approaches to treat dengue infection. (
  • Dengue infection: Global importance, immunopathology and management. (
  • Dengue is a viral infection . (
  • [ 84 ] The Novartis Institute for Tropical Diseases (NITD) in Singapore is carrying out research to find inhibitors of dengue viral target proteins to reduce the viral load during active infection. (
  • There is good evidence that sequential infection with the different serotypes of dengue virus increases the risk of more severe disease that can result in shock syndrome and death. (
  • The infection causes flu-like illness, and occasionally develops into a potentially lethal complication called severe dengue. (
  • Although recovery from infection by one of the serotypes provides lifelong immunity against it, cross-immunity is only partial and subsequent infections by other serotypes increase the risk of developing severe dengue. (
  • This infection total is more than three times the dengue burden estimate of the World Health Organization 2 . (
  • Stratification of our estimates by country allows comparison with national dengue reporting, after taking into account the probability of an apparent infection being formally reported. (
  • These new risk maps and infection estimates provide novel insights into the global, regional and national public health burden imposed by dengue. (
  • Dengue infection was laboratory-diagnosed by positive immunoglobulin M (IgM)-capture enzyme-linked immunosorbent assay (ELISA) (578 cases) and viral isolation (64 cases). (
  • Because of the reported outbreak in Tamaulipas, on August 25, 1995, TDH issued a dengue alert memorandum by facsimile to all local health departments, infection-control practitioners, and infectious disease physicians in south Texas. (
  • of these, 23 had virologic or serologic evidence of dengue infection. (
  • A small percentage of persons who have previously been infected by one dengue serotype develop bleeding and endothelial leak upon infection with another dengue serotype. (
  • Director-General of the Department of Disease Control (DDC), Dr. Suwanchai Wattanayingcharoenchai, elaborated that most cases of dengue infection were among citizens aged between 15 and 24, followed by those aged 10-14 and then 25-34. (
  • An estimated 74,000 to 75,000 people are expected to contract dengue this year and more deaths are likely now that infection has increased among younger individuals. (
  • Thus, in order to characterize the role of glycoprotein E in the pathogenesis of dengue virus infection, we first used network servers (http://bio.dfci. (
  • In statements to Granma newspaper, Eduardo Martínez, president of the Biotechnological and Pharmaceutical Industries Business Group, argued that such a system would make it possible to determine, upon the appearance of the first symptoms, whether it is dengue or a second infection. (
  • Investigators in UVM's Vaccine Testing Center and Center for Translational Global Infectious Disease Research (TGIR) have uncovered details of the human immune response to infection with dengue - a close "cousin" of the Zika virus - which 40 percent of the global population is at risk for contracting. (
  • Study findings, reported recently in the Lancet 's open-access journal EBioMedicine , illustrate new critical information that could provide much-needed help to evaluating dengue vaccine formulations and assist with advancing safe and efficacious candidate vaccines to help combat the most important mosquito-borne viral infection in our time. (
  • One of the challenges of dengue infection is that it can be caused by one of four versions - or serotypes - of the virus, which are numbered dengue 1 to 4. (
  • In this study, co-led by Huy Tu, a fifth-year Ph.D. candidate in the Cellular and Molecular Biomedical Sciences program, the group defined the evolution of the antibody response in dengue infection in a controlled human model where subjects were treated with a weakened version of the virus. (
  • The mild form of dengue is a serious annoyance and shock and die within a day, or quickly recover, if volume often is painful for those with it. (
  • 1) Outbreaks of the more severe form of dengue, DHF, occurred in Cuba in 1981 (2) and in Venezuela in 1989. (
  • For example, the entire genome sequence of the Aedes aegypti mosquito, the main carrier of dengue virus, has been decoded and is available to qualified researchers. (
  • 10) Adding to the concern of indigenous dengue transmission is the recent establishment in the United States of another known dengue vector, Aedes albopictus, which was probably imported in shipments of tires from Asia. (
  • Because of the year-round presence of the Aedes aegypti mosquito (a major vector for dengue) in southernmost Texas and the frequent movement of persons across the U.S.-Mexico border, the outbreak in adjacent Tamaulipas suggested an increased potential for imported and autochthonous cases in Texas, as had occurred during 1980 and 1986 (2). (
  • There is no specific medicine to treat dengue. (
  • Havana, Mar 21 (Prensa Latina) Cuba´s vaccine candidate to treat dengue has a safe technological platform, as informed by the Center for Genetic Engineering and Biotechnology (CIGB). (
  • Mosquito-borne diseases (MBD) outbreaks have increased drastically over the last decade with dengue, then Zika and chikungunya, and dengue again, with the latest outbreak having begun in 2019 and continuing over much of the period since. (
  • Dengue-like epidemics occurred in Egypt and on Java in 1779, but these may actually have been caused by chikungunya virus. (
  • Mosquito-borne diseases like dengue, malaria and chikungunya cases expected to ramp up after the recent rains. (
  • Dengue is caused by one of any of four related viruses: Dengue virus 1, 2, 3, and 4. (
  • Although, it is not usu- by other names) can be caused ally recognized, more than half the people who are infect- by any of 4 viruses within the ed with a dengue virus may be asymptomatic, which virus family Flaviviridae , would indicate a substantial underreporting of infections. (
  • Through a mechanism known as immune with imported cases essentially everywhere tourists, busi- enhancement, sequential infections with certain dengue ness people, and military personnel travel, whether dengue viruses set the stage for a far more serious complication, is recognized there or not. (
  • The mosquito acquires the these countries are in Southeast Asia and the Western virus by taking a blood meal from an infected human, the Pacific, but with the worldwide spread of all dengue types, principal amplifying host for these viruses, or from an this disease threatens residents in tropical and subtropical infected monkey. (
  • A vaccine with varying level of effectiveness for each of the 4 dengue viruses is available (and others are being researched), and WHO has issued a conditional recommendation on the use of the vaccine for highly endemic areas. (
  • 1990) The dengue viruses. (
  • G. J. Chang, Molecular biology of dengue viruses, 175-198 In: D. J. Gubler, G. Kuno (eds. (
  • We are currently assessing a tetravalent candidate, based on proteins of the four dengue viruses," CIGB added. (
  • Dengue virus is a member of the Flavivirus genus of viruses and can result in severe febrile illness. (
  • What are the symptoms of dengue and severe dengue? (
  • Severe dengue is a serious form of the illness. (
  • About 1 in 20 people who get sick with dengue will develop severe dengue. (
  • People are more likely to develop severe dengue if they have had dengue before, are pregnant, or are infants. (
  • Watch for signs and symptoms of severe dengue. (
  • Severe dengue often requires care at a hospital. (
  • Management of severe dengue requires careful attention to fluid management and proactive treatment of hemorrhage. (
  • Although the incidence of hemorrhagic dengue in United States travelers abroad is low,(13,15) clinicians in this country may encounter severe cases of dengue, particularly among immigrants from areas with a high incidence of DHF. (
  • 14,18,19) Nevertheless through the first half of the 20th century, dengue was generally described as a self-limited, nonfatal febrile illness, with occasional hemorrhagic manifestations such as petechiae, epistaxis, gingival bleeding and menorrhagia, that only rarely resulted in more severe or fatal outcomes. (
  • Severe dengue is a leading cause of serious illness and death among children in some Asian and Latin American countries. (
  • Occasionally it develops into a potentially lethal complication called severe dengue. (
  • Reports of dengue and severe dengue epidemics in the Region started in 1998 and have increased in frequency and spread ever since, with outbreaks occurring in Djibouti, Egypt, Oman, Pakistan, Saudi Arabia, Somalia, Sudan, and Yemen. (
  • Describe current dengue epidemiology and the populations who are at greatest risk for dengue and severe dengue in the United States. (
  • Recognize the three phases (febrile, critical, convalescent) and the three severity levels of symptomatic dengue (dengue, dengue with warning signs, severe dengue) based on a patient's clinical and laboratory findings. (
  • Admission to an intensive care unit is indicated for patients with dengue shock syndrome. (
  • My first assignment as the medical entomologist for the U.S.-Affiliated Pacific Islands (USAPIs) was to respond to the dengue outbreak in the Republic of the Marshall Islands (RMI). (
  • CHOLOMA, Honduras - More than 400 people died this year as one of the worst dengue epidemics on record swept through Central America - a type of outbreak that some scientists and public health officials are warning is likely to become more frequent and more widespread because of climate change. (
  • All the 4 serotypes of dengue virus have been known to have circulated in the Region during these outbreaks. (
  • One of the earliest, if not the first, dengue epidemics described in the medical literature occurred in Philadelphia in 1780. (
  • 5-7) Dengue epidemics were reported in various parts of the south- eastern United States through the 19th and 20th centuries, (6) most recently in Louisiana in 1945. (
  • 7) Dengue or dengue-like epidemics were reported through- out the 19th and early 20th centuries in the Americas, southern Europe, North Africa, the Middle East, Asia and Australia and on various islands in the Indian Ocean, South and Central Pacific and the Caribbean. (
  • 7) Deaths occurred during dengue epidemics in Australia in 1897 and in Greece in 1928, when over 1000 deaths were reported. (
  • 17) Hemorrhagic manifestations, including gastrointestinal hemorrhage, were described during dengue epidemics in Texas and Louisiana in 1922. (
  • The World Health Organization (WHO) has provided a number of free publications about dengue . (
  • From 1981 through 1986, 796 386 cases of DHF and 9774 deaths caused by dengue were reported to the World Health Organization (WHO) from countries in Southeast Asia. (
  • Presenters will also review dengue clinical classification, diagnosis, and general treatment guidelines based on World Health Organization and Centers for Disease Control and Prevention recommendations. (
  • Between 2008 and 2013 the number of reported dengue cases more than doubled, according to the World Health Organization, and the disease is spreading beyond its usual tropical environment. (
  • According to the World Health Organization (WHO), two-fifths of the world's population, or 2.5 billion people, are at risk of the disease, and that "there may be 50 million dengue infections worldwide every year. (
  • Dengue Vaccines: An Update. (
  • Other USAPI jurisdictions also fought dengue outbreaks during this time, including Guam, Palau, and the Federated States of Micronesia (FSM). (
  • 9) Outbreaks of indigenous dengue transmission occurred in Texas in 1980 and again in 1986. (
  • While dengue has long been present in Costa Rica, there have been significant outbreaks in recent years. (
  • The researchers tagged dengue virus and cell membranes with fluorescent probes that glow when the virus and membranes fuse. (
  • A new system for rapid diagnosis of dengue should be available in 2023. (
  • 2002) Structure of dengue virus: implications for flavivirus organization, matu--ration, and fusion. (
  • We then pair the resulting risk map with detailed longitudinal information from dengue cohort studies and population surfaces to infer the public health burden of dengue in 2010. (
  • These free NIAID databases provide scientists with the means to analyze and extract vast amount of genomic data, and advances the understanding and treatment of dengue disease. (
  • Single-dose methylprednisolone showed no mortality benefit in the treatment of dengue shock syndrome in a prospective, randomized, double-blind, placebo-controlled trial. (
  • Persistent Emergence of Dengue geographic distribution of dengue spreading, but the seri- as well as molecular approaches will soon be available and ousness of its complications is being recognized (available hold out promise of tools we need to eliminate or eradicate from this scourge. (
  • Here we undertake an exhaustive assembly of known records of dengue occurrence worldwide, and use a formal modelling framework to map the global distribution of dengue risk. (
  • In Tamaulipas, transmission of dengue ended by late December 1995. (
  • For this reason, a person can be infected with a dengue virus as many as four times in his or her lifetime. (
  • KSF 103 methanolic extract ( Streptomyces KSF 103 ME), which consists of a number of potential antiviral compounds, were investigated against dengue virus serotype 2 (DENV-2). (
  • Researchers have discovered a key step in how the dengue virus infects a cell. (
  • To infect a cell, the dengue virus initially binds to the cell surface. (
  • However, attempts to fuse dengue virus under either of these conditions have been unsuccessful. (
  • A research team led by Dr. Leonid V. Chernomordik at NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) set out to investigate how the dengue virus fuses with its target membranes. (
  • The researchers discovered that 2 conditions are essential for dengue virus fusion. (
  • We spent several years trying to understand how the dengue virus fuses with its target membrane," Chernomordik says. (
  • The vaccine, made by French pharmaceutical company Sanofi, is the first of several in development and is designed to help prevent all four strains of the dengue virus. (
  • The actions protect against dengue, the Zika virus and other mosquito borne infections. (
  • Quantitative synthetic RNA for Dengue virus type 1 can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. (
  • To download a certificate of analysis for Quantitative Synthetic RNA from Dengue virus type 1 ( VR-3228SD ), enter the lot number exactly as it appears on your product label or packing slip. (
  • The certificate of analysis for that lot of Quantitative Synthetic RNA from Dengue virus type 1 ( VR-3228SD ) is not currently available online. (
  • The major envelope glycoprotein E of dengue (DEN) virus plays a central role in the biology of flaviviruses. (
  • In our study, the sequence at 281-295 amino acid (aa) for den-gue virus type 1 HAWAII strain and the sequence at 345-359, 383-397 for dengue virus type 2 NGC strain were predicted as the more prevalent epi-topes by using multiple parameters and different analysis softwares, respectively. (
  • 2003) A ligand-binding pockets in the dengue virus envelop glycoprotein. (
  • Here we show for the first time that the uncharacterized protein FLJ11286, which we refer to as IRAV, is induced by dengue in an interferon dependent manner and displays antiviral activity against dengue virus. (
  • Furthermore, we show that overexpression of IRAV results in a diminished stability of dengue virus mRNA, suggesting a role for IRAV in mediating the stability of viral RNA. (
  • The vaccine candidate to fight dengue is based on recombinant proteins: a safe technological platform," CIGB tweeted. (
  • Of the 29 patients with laboratory-diagnosed dengue, eight reported recent travel to areas with endemic dengue outside Mexico. (
  • Dengue prevention and control depends on effective vector control measures. (
  • Packets of information about dengue prevention were mailed to 13,000 primary-care and emergency department physicians throughout the state. (
  • Community education efforts included a press release advising the public about the threat of dengue and recommendations for preventing mosquito exposure, the distribution of informational material on dengue prevention and the mosquito life cycle (6000 posters and 200,000 pamphlets in English and Spanish). (
  • I believe that to get Dengue you have to actually be bitten by the infected [carrier] mosquito, So a good dose of mosquito prevention should keep the worries down. (
  • Though Dengvaxia is now the only proven form of medical prevention for dengue, it is still only partially effective. (
  • Despite the vaccine's pitfalls, the need for dengue prevention is growing worldwide. (
  • Piles of old car tires gathered on Majuro for building materials to construct a seawall for protection against sea-level rise and creating major breeding sites for dengue mosquito vectors. (
  • Tragically, DHF is a leading cause complications, dengue diagnosis, and dengue epidemiolo- of hospitalization and death of children in several Asian gy. (
  • According to a civic report on vector-borne diseases released on Monday, nine deaths and a total of 2,708 dengue cases have been recorded this season till November 6, which is the highest count since 2017 for the same period. (
  • From January to June 8 this year, the National Epidemiology Center has so far logged in a total of 42,207 cases and 193 deaths due to dengue. (
  • In Honduras, which accounted for more than 40 percent of the dengue deaths in Central America this year, according to the Pan American Health Organization, the effects of climate change have been compounded by government dysfunction, political tumult and public apathy. (
  • This issue of Emerging Infectious Diseases includes require hospitalization each year, a substantial proportion some very interesting reports on dengue and its clinical of whom are children. (
  • Dengue Branch and the Division of Vector Borne Infectious Diseases, Centers for Disease Control, CID, Fort Collins, CO. Duane J. Gubler, Sc.D and Edward B. Hayes, MD. (
  • Dengue is often a leading cause of illness in areas with risk. (
  • However, during the first week of July 1996, cases of dengue-like illness were reported in Tampico. (
  • TDH conducted active surveillance for dengue-like illness through telephone calls and personal visits to area hospitals and clinical and reference laboratories. (
  • Dengue is the most common and important arthropod-borne viral (arboviral) illness in humans. (
  • Using cartographic approaches, we estimate there to be 390 million (95% credible interval 284-528) dengue infections per year, of which 96 million (67-136) manifest apparently (any level of disease severity). (
  • It is rarest of the rare to see mucormycosis as a post-recovery complication in a dengue patient as this condition is generally seen in people who have a history of diabetes, compromised immunity and various other infections. (
  • Recent studies have revealed that dengue, a disease that is well recognized in Asia and the Americas, may be commonly misdiagnosed as malaria in Africa. (
  • The transmission of mosquito-borne diseases like malaria and dengue can now be tracked using mobile health technology and software. (
  • Dengue and malaria cases have increased in the national capital and Gurugram has increased screening at the border to curb the rising cases. (
  • The Colombian authorities have been concerned for several months now about the spread of mosquito-transmitted diseases such as dengue and malaria, following an exceptionally hot and dry season. (
  • The dengue mosquito larvae breed in clear, standing water, while those of malaria thrive even in dirty water. (
  • The global incidence of dengue has grown dramatically in recent decades. (
  • We have evidence our Wolbachia method is safe, sustainable and dramatically reduces incidence of dengue. (
  • This information may help investigators identify the mosquito proteins that are essential to support dengue replication and transmission, and allow them eliminate the proteins in transgenic insects. (
  • IRAV associates with dengue and host proteins, and interacts with MOV10. (
  • Three-year Efficacy and Safety of Takeda's Dengue Vaccine Candidate (TAK-003). (
  • 13-15) From 1980 through 1989, 1457 suspected and 276 confirmed cases of dengue in the continental United States and Hawaii were reported to the Centers for Disease Control. (
  • Under the agreement, the DILG is tasked to lead all local government units to implement the campaign dubbed "Aksyon Barangay Kontra Dengue," particularly in high-risk communities such as urban centers with poor environmental management of household waste. (
  • Dengue symptoms usually last 2-7 days. (
  • Mucormycosis post dengue is a new observation and hence, patients with a recent history of dengue should remain actively updated about their health and consult a healthcare expert immediately after noticing any new symptoms, doctors at the Apollo hospital said. (
  • On average, dengue becomes symptomatic after a 4- to 10-day incubation period (range, 3-14 days). (
  • Children younger than 15 years who have dengue usually have a nonspecific febrile syndrome, which may be accompanied by a maculopapular rash. (
  • Hundreds of thousands of cases of dengue and DHF are reported each year in tropical regions of the Americas, Africa, Asia and Oceania. (
  • From 1980 through 1987, 879 632 cases of dengue were reported to the Pan American Health Organization from countries in the American region. (
  • The second reason dengue should concern health care providers in this country is the potential for encountering cases of dengue among travelers arriving from dengue-endemic areas. (
  • Mosquito control teams equipped with cell phones can visit homes where dengue cases have occurred and immediately send data back from the field or save it to a local database. (
  • In response to the notification from Mexico, TDH intensified surveillance efforts for dengue, resulting in identification of 29 laboratory-diagnosed cases in Texas residents, including seven persons with no history of travel outside the state. (
  • During July-December 1995, health authorities in Tamaulipas (1994 population: 2,459,087) reported 4758 suspected cases of dengue to health authorities in Mexico. (
  • In 2013, a dengue epidemic produced more cases than ever in Costa Rica, infecting nearly 50,000 people. (
  • An official revealed that at least 93 new dengue cases were reported in Odisha, taking the total number of affected people to 2,593 since June. (
  • Health ministry figures show that India has recorded 15,893 dengue cases in 2013, a sharp increase from last year. (
  • Globally, about three quarters of a million fewer global dengue cases have been occurred in 2020. (
  • The case reported at the Apollo hospital in south Delhi comes amid a huge spike in the number of dengue cases in the national capital. (
  • In a statement issued on Saturday, the Apollo hospital said, 'A 49-year-old male has been reported to be one the rare cases of post-dengue mucormycosis by a team of doctors at the hospital. (
  • Calabarzon registered 4,742 cases while Davao registered a 30-percent increase with 4,364 incidents of dengue. (
  • Previous trials involving Wolbachia - commonly found in fruit flies and other insects - also showed positive results in reducing dengue cases, researchers said. (
  • Dengue is the most rapidly spreading mosquito-borne disease in the world with more than 50 million cases globally every year, including about eight million in Indonesia. (
  • This report summarizes results of dengue surveillance in the U.S.-Mexico border area during 1995-1996. (
  • I was bitten and caught Dengue in 1996 in Ambergris Caye. (
  • In one NIAID-funded contract, researchers evaluated about 7,500 antiviral compounds in vitro to test their efficacy against dengue. (
  • NIAID also provides the scientific community with the genetic sequence data from several hundreds of viral strains that have been isolated from dengue-infected people. (
  • The early history of dengue is clouded by the similarity of its clinical picture to that of other febrile illnesses. (
  • In clinical trials, the vaccine reduced the chance of contracting dengue by 60 percent. (
  • The new mobile health platform, which makes use of the existing communications infrastructure in Mexico, gives dengue researchers near real-time monitoring capacity as well as the ability to rapidly transmit findings. (
  • Identify the indicated treatment group (A, B, C), including hospital admission and intravenous fluids management recommendations, based on dengue phase and severity. (