AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceHealth CareGeographicals
DengueDengue VirusSevere DengueDengue VaccinesAedesInsect VectorsAntibodies, ViralCulicidaeThailandNicaraguaAntibody-Dependent EnhancementViral Nonstructural ProteinsDisease OutbreaksVietnamFlavivirusMosquito ControlSerotypingImmunoglobulin MPuerto RicoDisease VectorsTravelBrazilEnzyme-Linked Immunosorbent AssayRNA, ViralAmericasViral Envelope ProteinsSri LankaCubaRainAntigens, ViralPolynesiaSingaporeTranslatingGenetics, BehavioralIndiaPostural BalanceAutophagyCell LineRhodniusJapanCambodiaHoltzman Inkblot TestCommunicable DiseasesMusicChikungunya virusAustraliaFeverElectronic MailFood Dispensers, AutomaticEditorial PoliciesAuthorshipPeriodicals as TopicPostal ServiceInternet
Dengue: An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.Dengue Virus: A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.Severe Dengue: A virulent form of dengue characterized by THROMBOCYTOPENIA and an increase in vascular permeability (grades I and II) and distinguished by a positive pain test (e.g., TOURNIQUET PAIN TEST). When accompanied by SHOCK (grades III and IV), it is called dengue shock syndrome.Dengue Vaccines: Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.Aedes: A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.Insect Vectors: Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Culicidae: A family of the order DIPTERA that comprises the mosquitoes. The larval stages are aquatic, and the adults can be recognized by the characteristic WINGS, ANIMAL venation, the scales along the wing veins, and the long proboscis. Many species are of particular medical importance.Thailand: Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.NicaraguaAntibody-Dependent Enhancement: Enhancement of viral infectivity caused by non-neutralizing antibodies. There are at least two mechanisms known to account for this: mediation by Fc receptors (RECEPTORS, FC) or by complement receptors (RECEPTORS, COMPLEMENT). Either the virus is complexed with antiviral IMMUNOGLOBULIN G and binds to Fc receptors, or virus is coated with antiviral IMMUNOGLOBULIN M and binds to complement receptors.Viral Nonstructural Proteins: Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.Disease Outbreaks: Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.VietnamFlavivirus: A genus of FLAVIVIRIDAE containing several subgroups and many species. Most are arboviruses transmitted by mosquitoes or ticks. The type species is YELLOW FEVER VIRUS.Mosquito Control: The reduction or regulation of the population of mosquitoes through chemical, biological, or other means.Serotyping: Process of determining and distinguishing species of bacteria or viruses based on antigens they share.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Puerto Rico: An island in the Greater Antilles in the West Indies. Its capital is San Juan. It is a self-governing commonwealth in union with the United States. It was discovered by Columbus in 1493 but no colonization was attempted until 1508. It belonged to Spain until ceded to the United States in 1898. It became a commonwealth with autonomy in internal affairs in 1952. Columbus named the island San Juan for St. John's Day, the Monday he arrived, and the bay Puerto Rico, rich harbor. The island became Puerto Rico officially in 1932. (From Webster's New Geographical Dictionary, 1988, p987 & Room, Brewer's Dictionary of Names, 1992, p436)Disease Vectors: Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.Travel: Aspects of health and disease related to travel.BrazilEnzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Americas: The general name for NORTH AMERICA; CENTRAL AMERICA; and SOUTH AMERICA unspecified or combined.Viral Envelope Proteins: Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.Sri LankaCuba: An island in the Greater Antilles in the West Indies, south of Florida. With the adjacent islands it forms the Republic of Cuba. Its capital is Havana. It was discovered by Columbus on his first voyage in 1492 and conquered by Spain in 1511. It has a varied history under Spain, Great Britain, and the United States but has been independent since 1902. The name Cuba is said to be an Indian name of unknown origin but the language that gave the name is extinct, so the etymology is a conjecture. (From Webster's New Geographical Dictionary, 1988, p302 & Room, Brewer's Dictionary of Names, 1992, p132)Rain: Water particles that fall from the ATMOSPHERE.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Polynesia: The collective name for the islands of the central Pacific Ocean, including the Austral Islands, Cook Islands, Easter Island, HAWAII; NEW ZEALAND; Phoenix Islands, PITCAIRN ISLAND; SAMOA; TONGA; Tuamotu Archipelago, Wake Island, and Wallis and Futuna Islands. Polynesians are of the Caucasoid race, but many are of mixed origin. Polynesia is from the Greek poly, many + nesos, island, with reference to the many islands in the group. (From Webster's New Geographical Dictionary, 1988, p966 & Room, Brewer's Dictionary of Names, 1992, p426)SingaporeTranslating: Conversion from one language to another language.Genetics, Behavioral: The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.IndiaPostural Balance: A POSTURE in which an ideal body mass distribution is achieved. Postural balance provides the body carriage stability and conditions for normal functions in stationary position or in movement, such as sitting, standing, or walking.Autophagy: The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Rhodnius: A genus of the subfamily TRIATOMINAE. Rhodnius prolixus is a vector for TRYPANOSOMA CRUZI.JapanCambodiaHoltzman Inkblot Test: Personality evaluation based on the scoring of several variables as a result of the subject's responses in perceiving 47 inkblot plates.Communicable DiseasesMusic: Sound that expresses emotion through rhythm, melody, and harmony.Chikungunya virus: A species of ALPHAVIRUS causing an acute dengue-like fever.Australia: The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

Scientists try new strategy to eradicate dengue fever.(1/2084)

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Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. (2/2084)

T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with <72 h of fever were studied. Plasma levels of 80-kDa soluble tumor necrosis factor receptors (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-gamma and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-alpha was detectable more often in DHF than in DF or OFIs (P<.05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.  (+info)

Variation in oral susceptibility to dengue type 2 virus of populations of Aedes aegypti from the islands of Tahiti and Moorea, French Polynesia. (3/2084)

Twenty three samples of Aedes aegypti populations from the islands of Tahiti and Moorea (French Polynesia) were tested for their oral susceptibility to dengue type 2 virus. The high infection rates obtained suggest that the artificial feeding protocol used was more efficient than those previously described. Statistical analysis of the results allowed us to define two distinct geographic areas on Tahiti with respect to the susceptibility of Ae. aegypti: the east coast, with homogeneous infection rates, and the west coast, with heterogeneous infection rates. No geographic differences could be demonstrated on Moorea. The possible mechanisms of this phenomenon are discussed in connection with recent findings on the variability of susceptibility of Ae. aegypti to insecticides.  (+info)

Serologic evidence for an epizootic dengue virus infecting toque macaques (Macaca sinica) at Polonnaruwa, Sri Lanka. (4/2084)

Dengue is one of the most rapidly emerging diseases in the tropics. Humans are the principal reservoir of dengue viruses. It is unclear if nonhuman primates also serve as a reservoir of human dengue viruses under certain conditions. In this study, a cross-sectional serologic survey was carried out to characterize the pattern of transmission of a recently identified dengue virus among toque macaques in Sri Lanka. The results indicated that an epizootic dengue virus was active among the macaques. A single epizootic had taken place between October 1986 and February 1987 during which 94% of the macaques within the 3 km2 study site were exposed to the virus. The epizootic was highly focal in nature because macaques living 5 km from the study population were not exposed to the virus. The transmission of dengue viruses among macaques in the wild may have important public health implications.  (+info)

Bacterial lipopolysaccharide inhibits dengue virus infection of primary human monocytes/macrophages by blockade of virus entry via a CD14-dependent mechanism. (5/2084)

Monocytes/macrophages (MO/Mphi) are the major target cells for both dengue virus (DV) and bacterial lipopolysaccharide (LPS), and the aim of this study was to define their interactions. We had found that LPS markedly suppressed DV infection of primary human MO/Mphi when it was added to cultures prior to or together with, but not after, viral adsorption. The inhibitory effect of LPS was direct and specific and was not mediated by LPS-induced secretion of cytokines and chemokines such as tumor necrosis factor alpha, interleukin-1beta (IL-1beta), IL-6, IL-8, IL-12, alpha interferon, MIP-1alpha, and RANTES. In fact, productive DV infection was not blocked but was just postponed by LPS, with a time lag equal to one viral replication cycle. Time course studies demonstrated that LPS was only effective in suppressing DV infection of MO/Mphi that had not been previously exposed to the virus. At various time points after viral adsorption, the level of unbound viruses that remained free in the culture supernatants of LPS-pretreated cultures was much higher than that of untreated controls. These observations suggest that the LPS-induced suppression of DV replication was at the level of virus attachment and/or entry. Blockade of the major LPS receptor, CD14, with monoclonal antibodies MY4 or MoS39 failed to inhibit DV infection but could totally abrogate the inhibitory effect of LPS. Moreover, human serum could significantly enhance the LPS-induced DV suppression in a CD14-dependent manner, indicating that the "binding" of LPS to CD14 was critical for the induction of virus inhibition. Taken together, our results suggest that LPS blocked DV entry into human MO/Mphi via its receptor CD14 and that a CD14-associated cell surface structure may be essential for the initiation of a DV infection.  (+info)

A deviation bar chart for detecting dengue outbreaks in Puerto Rico. (6/2084)

OBJECTIVES: A Centers for Disease Control and Prevention deviation bar chart (Statistical Software for Public Health Surveillance) and laboratory-based surveillance data were evaluated for their utility in detecting dengue outbreaks in Puerto Rico. METHODS: A significant increase in dengue incidence was defined as an excess of suspected cases of more than 2 SDs beyond the mean for all 4-week periods from April through June (the period of lowest seasonal incidence), 1989 through 1993. An outbreak was defined as a cumulative annual rate of reported dengue greater than 3 per 1000 population. RESULTS: Retrospective application of the system to 1994 data showed agreement with previous analyses. In 1995 and 1996, 36.4% and 27.3%, respectively, of municipalities with a significant increase in reports for 2 or more consecutive weeks before the first week of September had an outbreak, compared with 9.0% (in 1995, P = .042) and 6.0% (in 1996, P = .054) of towns without a significant increase. The system showed sensitivity near 40%, specificity near 89%, and accuracy in classifying municipalities near 84%. CONCLUSIONS: This method provides a statistically based, visually striking, specific, and timely signal for dengue control efforts.  (+info)

Effects of dengue fever during pregnancy in French Guiana. (7/2084)

To determine the effects of dengue fever (DF) during pregnancy, pregnant women presenting with a dengue-like syndrome at a hospital in Saint-Laurent du Maroni, French Guiana, from 1 January 1992 to 1 April 1998 were studied. The diagnosis of DF was made by serological tests, virus isolation on AP 61 mosquito cells, and/or reverse transcriptase polymerase chain reaction analysis. Twenty-two women had either probable or confirmed DF. Dengue virus serotype 2 was detected in four cases, and dengue virus serotype 1 was detected in one. Three fetuses died following the onset of the disease, and three cases of prematurity occurred. All infants appeared normal during physical examination, and no neonatal DF was diagnosed. In conclusion, DF in pregnant women did not cause any infant abnormality, but it may have been responsible for fetal death. The rate of fetal death associated with DF (13.6%) was much higher than the mean rate for the gynecology unit at the hospital (1.9%). However, these differences were not significant, and consequently these preliminary results need to be confirmed.  (+info)

Evaluation of the MRL diagnostics dengue fever virus IgM capture ELISA and the PanBio Rapid Immunochromatographic Test for diagnosis of dengue fever in Jamaica. (8/2084)

We evaluated two new commercial dengue diagnostic tests, the MRL Diagnostics Dengue Fever Virus IgM Capture ELISA and the PanBio Rapid Immunochromatographic Test, on serum samples collected during a dengue epidemic in Jamaica. The MRL ELISA method correctly identified 98% (78 of 80) of the samples as dengue positive, while the PanBio test identified 100% (80 of 80). Both tests were 100% (20 samples of 20) specific.  (+info)

Unique Impacts of HBV Co-infection on Clinical and Laboratory Findings in a Recent Dengue Outbreak in China | The American...Unique Impacts of HBV Co-infection on Clinical and Laboratory Findings in a Recent Dengue Outbreak in China | The American...
High prevalence of hepatitis B virus (HBV) infection in China offers a unique setting to examine HBVs influence on the presentation of dengue fever. In 398 patients admitted for suspected dengue fever, 89% (353/398) were positive for dengue IgM antibodies. Among dengue-infected patients, 8% (29/353) had chronic HBV co-infection. Only dengue virus serotype 1 was identified by virus isolation and reverse transcriptase-polymerase chain reaction assays. No case of dengue hemorrhagic fever/dengue shock syndrome was diagnosed. In addition to routine clinical tests, inter-leukin 2 (IL-2), IL-4, IL-6, IL-10, interferon γ (IFNγ), and tumor necrosis factor α (TNFα) levels were measured in the sera of 95% (334/353) of dengue-infected subjects as well as controls. Surprisingly, HBV/dengue co-infected patients made less IL-6 (P < 0.05) and TNFα (P < 0.05) than patients with only dengue infection. Similar levels of IL-4, IL-10, and IFNγ were found in both groups. Thus, HBV co-infection seems to alter the
Dengue Dengue Dengue - La Alianza ProfanaDengue Dengue Dengue - La Alianza Profana
Schon mal was von dem gefährlichen Virus Denguefieber gehört? Mindestens genauso ansteckend ist der treibende Cumbia-Future-Sound des Duos Dengue Dengue Dengue! aus der peruanischen Millionenmetropole Lima. Mit wobbeligen Bässen ausgeliehen aus dem Dubstep, futuristischen Sounds seziert aus dem Techno und psychedelischen Sounds inspiriert aus der 70er Jahre Cumbia-Chicha hebt Dengue Dengue Dengue! den Cumbia-Digital Sound auf ein neues Level. Auf den Live-Shows von Dengue Dengue Dengue! bekommt man das Gefühl mit einem UFO direkt auf dem peruanischen Inkatempel Machu-Pichu zu landen - inmitten eines futuristischen Technoraves mit Ausblick über den amazonischen Urwald. Dengue Dengue Dengue! ist ein junges Duo bestehend aus Felipe Salmon und Rafael Pereira. Beide sind auch Teil des "Colectivo Auxiliar", ein peruanisches Sound-Laboratorium. Der Name Dengue Dengue Dengue! entspringt einer Enrique Lynch Platte, der darauf einen Rhythmus spielt, der sich Dengue nennt. Das Projekt überzeugt von ...
Dengue Fever Prevention - Healthcare6Dengue Fever Prevention - Healthcare6
Death because of fever is increasing day by day. Dengue fever is the main type of fever which leads to this increased mortality rate It is important to prevent the disease. if the disease caused have to be treated properly. Proper medicine and the rest is the main defensive way to prevent dengue fever dengue fever is also called break bone fever. Dengue fever is a viral disease the dengue virus which is spread by mosquito is the main reason behind dengue fever.. If once dengue fever host it will make antibodies over the body for the lifetime the first time of dengue fever is known as Type 1 dengue fever is Dengue fever caused more than one time then then it would be type 2 dengue fever.. ...
Detection of Dengue Virus RNA in Patients after Primary or Secondary Dengue Infection by Using the TaqMan Automated...Detection of Dengue Virus RNA in Patients after Primary or Secondary Dengue Infection by Using the TaqMan Automated...
Dengue fever is a severe health problem in tropical areas, with two-thirds of the world population at risk of infection (24). Four virus serotypes and even more quasispecies can be differentiated both in the transmitting insect (A. aegypti) and in the blood of patients with acute dengue fever (26). During recent decades Europe has been free of dengue infections, but as a result of increasing tourism every year several thousand tourists return to European countries with acute dengue fever.. In the second half of 1998 we diagnosed 172 dengue patients. All patients were European tourists, most of whom had experienced a disease with high fever and headache for several days. Usually early serum samples were taken 4 to 8 days after the onset of symptoms. Therefore, early serum samples without dengue virus antibodies at all or with either IgG or IgM antibodies were obtained from only 25 patients (15%). In 20 early samples viral RNA could be demonstrated by TaqMan PCR, in one case even in the presence ...
Scanning electron microscopy of the four larval instars of the Dengue fever vector Aedes aegypti (Diptera: Culicidae)Scanning electron microscopy of the four larval instars of the Dengue fever vector Aedes aegypti (Diptera: Culicidae)
... Stefan Schaper1 & Francisco Hernández-Chavarría2. 1 Institute for Zoology, Tierärztliche Hochschule Hannover, Germany and Universidad Nacional, Heredia, Costa Rica.. 2 Centro de Investigación en Estructuras Microscópicas and Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica; [email protected] Received 09-IV-2003. Corrected 16-IX-2005. Accepted 23-III-2006.. Abstract: Aedes aegypti is the main insect vector of Dengue fever and dengue hemorrhagic fever/dengue shock syndrome and represents the only vulnerable element in the control of this disease. Therefore, the identification and quantification of this mosquito is an important task; however, the majority of taxonomic keys are based on the 4th larval instar. For that reason, this study describes the four larval instars of A. aegypti using scanning electron microscopy. Morphological changes ...
Dengue Bites Back | HealthMapDengue Bites Back | HealthMap
Last week the World Health Organization (WHO) reported that dengue is the worlds fastest-spreading tropical disease. As reported by Reuters, dengue is a threat that is present in more than 125 countries.. The WHO estimates that 50 and 100 million dengue infections occur worldwide every year, but acknowledges that this is likely a conservative figure. The CDC estimates that about 2.5 billion people, or 40% of the worlds population, live in areas where there is a risk of dengue transmission. The areas in which dengue is endemic include Asia, Africa and Latin America, but it is present on all continents.. Dengue fever is caused by any one of four dengue virus serotypes and is transmitted by the Aedes aegypti and Aedes albopictus mosquito species. Infection with one serotype does not provide immunity against other dengue serotypes, and multiple infections put people at risk for dengue hemorrhagic fever and dengue shock syndrome. Dengue symptoms typically begin four to seven days following the ...
Prediction of dengue disease severity among pediatric Thai patients us by James A. Potts, Robert V. Gibbons et al."Prediction of dengue disease severity among pediatric Thai patients us" by James A. Potts, Robert V. Gibbons et al.
BACKGROUND: Dengue virus is endemic in tropical and sub-tropical resource-poor countries. Dengue illness can range from a nonspecific febrile illness to a severe disease, Dengue Shock Syndrome (DSS), in which patients develop circulatory failure. Earlier diagnosis of severe dengue illnesses would have a substantial impact on the allocation of health resources in endemic countries. METHODS AND FINDINGS: We compared clinical laboratory findings collected within 72 hours of fever onset from a prospective cohort children presenting to one of two hospitals (one urban and one rural) in Thailand. Classification and regression tree analysis was used to develop diagnostic algorithms using different categories of dengue disease severity to distinguish between patients at elevated risk of developing a severe dengue illness and those at low risk. A diagnostic algorithm using WBC count, percent monocytes, platelet count, and hematocrit achieved 97% sensitivity to identify patients who went on to develop DSS while
IJMS | Free Full-Text | Serum Galectin-9 and Galectin-3-Binding Protein in Acute Dengue Virus InfectionIJMS | Free Full-Text | Serum Galectin-9 and Galectin-3-Binding Protein in Acute Dengue Virus Infection
Dengue fever is a serious threat for public health and induces various inflammatory cytokines and mediators, including galectins and glycoproteins. Diverse immune responses and immunological pathways are induced in different phases of dengue fever progression. However, the status of serum galectins and glycoproteins is not fully determined. The aim of this study was to investigate the serum concentration and potential interaction of soluble galectin-1, galectin-3, galectin-9, galectin-3 binding protein (galectin-3BP), glycoprotein 130 (gp130), and E-, L-, and P-selectin in patients with dengue fever in acute febrile phase. In this study, 317 febrile patients (187 dengue patients, 150 non-dengue patients that included 48 patients with bacterial infection and 102 patients with other febrile illness) who presented to the emergency department and 20 healthy controls were enrolled. Our results showed the levels of galectin-9 and galectin-3BP were significantly higher in dengue patients than those in healthy
Aberrant monocyte responses predict and characterize dengue virus infection in individuals with severe disease | Journal of...Aberrant monocyte responses predict and characterize dengue virus infection in individuals with severe disease | Journal of...
Currently, several assays can diagnose acute dengue infection. However, none of these assays can predict the severity of the disease. Biomarkers that predicts the likelihood that a dengue patient will develop a severe form of the disease could permit more efficient patient triage and allows better supportive care for the individual in need, especially during dengue outbreaks. We measured 20 plasma markers i.e. IFN-γ, IL-10, granzyme-B, CX3CL1, IP-10, RANTES, CXCL8, CXCL6, VCAM, ICAM, VEGF, HGF, sCD25, IL-18, LBP, sCD14, sCD163, MIF, MCP-1 and MIP-1β in 141 dengue patients in over 230 specimens and correlate the levels of these plasma markers with the development of dengue without warning signs (DWS−), dengue with warning signs (DWS+) and severe dengue (SD). Our results show that the elevation of plasma levels of IL-18 at both febrile and defervescence phase was significantly associated with DWS+ and SD; whilst increase of sCD14 and LBP at febrile phase were associated with severity of dengue disease
Discovery and Characterization of Potential Prognostic Biomarkers for Dengue Hemorrhagic Fever | The American Journal of...Discovery and Characterization of Potential Prognostic Biomarkers for Dengue Hemorrhagic Fever | The American Journal of...
Abstract. Half a million patients are hospitalized with severe dengue every year, many of whom would die without timely, appropriate clinical intervention. The majority of dengue cases are uncomplicated; however, 2-5% progress to severe dengue. Severe dengue cases have been reported with increasing frequency over the last 30 years. To discover biomarkers for severe dengue, we used surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to analyze dengue virus positive serum samples from the acute phase of infection. Using this method, 16 proteins were identified as candidate biomarkers for severe dengue. From these 16 biomarkers, three candidates were selected for confirmation by enzyme-linked immunosorbent assay and Western blot: vitronectin (Vtn, 55.1 kDa), hemopexin (Hx, 52.4 kDa), and serotransferrin (Tf, 79.2 kDa). Vitronectin, Hx, and Tf best differentiated between dengue and severe dengue.
Climatic factors influencing dengue incidence in an epidemic area of Nepal | BMC Research Notes | Full TextClimatic factors influencing dengue incidence in an epidemic area of Nepal | BMC Research Notes | Full Text
Geographic expansion of dengue incidence has drawn a global interest to identify the influential factors that instigate the spread of this disease. The objective of this study was to find the environmental factors linked to dengue incidence in a dengue epidemic area of Nepal by negative binomial models using climatic factors from 2010 to 2017. Minimum temperature at lag 2 months, maximum temperature and relative humidity without lag period significantly affected dengue incidence. Rainfall was not associated with dengue incidence in Chitwan district of Nepal. The incident rate ratio (IRR) of dengue case rise by more than 1% for every unit increase in minimum temperature at lag 2 months, maximum temperature and relative humidity, but decrease by .759% for maximum temperature at lag 3 months. Considering the effect of minimum temperature of previous months on dengue incidence, the vector control and dengue management program should be implemented at least 2 months ahead of dengue outbreak season.
Tri-phasic fever in dengue fever<...Tri-phasic fever in dengue fever<...
TY - JOUR. T1 - Tri-phasic fever in dengue fever. AU - Pradeepa, H. D.. AU - Rao, Sathish B.. AU - Ganaraj, B.. AU - Bhat, Gopalakrishna. AU - Chakrapani, M.. PY - 2018/4/1. Y1 - 2018/4/1. N2 - Dengue fever is an acute febrile illness with a duration of 2-12 days. Our observational study observed the 24-h continuous tympanic temperature pattern of 15 patients with dengue fever and compared this with 26 others with fever due to a non-dengue aetiology. A tri-phasic fever pattern was seen among two-thirds of dengue fever patients, but in only one with an inflammatory disease. One-third of dengue fever patients exhibited a single peak temperature. Continuous temperature monitoring and temperature pattern analysis in clinical settings can aid in the early differentiation of dengue fever from non-dengue aetiology.. AB - Dengue fever is an acute febrile illness with a duration of 2-12 days. Our observational study observed the 24-h continuous tympanic temperature pattern of 15 patients with dengue ...
Clinical Profiles of Dengue Infection during an Outbreak in Northern IndiaClinical Profiles of Dengue Infection during an Outbreak in Northern India
|i|Introduction.|/i| Dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), and expanded dengue syndrome (EDS) with atypical presentations, thus posing a diagnostic dilemma. Unless we are aware of these presentations, diagnosis as well as early initiation of treatment becomes difficult. We studied the various clinical presentations of dengue infection during an outbreak of disease in 2015.|i| Materials and Methods|/i|. A total of 115 confirmed cases of dengue infection from Department of Medicine of Deen Dayal Upadhyay Hospital, New Delhi, were enrolled in this observational study.|i| Results.|/i| The common signs and symptoms of dengue infection were fever, headache, body ache, backache, retro-orbital pain, bleeding manifestations, and rash in 100%, 87%, 86%, 58%, 41%, 21%, and 21%, respectively. Nonspecific or warning
Dengue fever cases continue rise in Sri Lanka, death toll now 40 - Outbreak News TodayDengue fever cases continue rise in Sri Lanka, death toll now 40 - Outbreak News Today
The capital region of Colombo has recorded 7369 cases to date alone.. Local media reports that the death toll due to dengue is 40 in Sri Lanka to date.. The World Health Organization says dengue is transmitted by the bite of a mosquito infected with one of the four dengue virus serotypes. It is a febrile illness that affects infants, young children and adults with symptoms appearing 3-14 days after the infective bite.. Dengue is not transmitted directly from person-to-person and symptoms range from mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash.. Severe dengue (also known as dengue hemorrhagic fever) is characterized by fever, abdominal pain, persistent vomiting, bleeding and breathing difficulty and is a potentially lethal complication, affecting mainly children. Early clinical diagnosis and careful clinical management by trained physicians and nurses increase survival of patients.. Related: ...
ISRCTN - ISRCTN25394628: The effectiveness of a fluid chart in the outpatient management of suspected dengue cases: a pilot...ISRCTN - ISRCTN25394628: The effectiveness of a fluid chart in the outpatient management of suspected dengue cases: a pilot...
Dengue is a viral infection spread by mosquitoes. It is endemic in Malaysia, as it is in most tropical countries. Worldwide, dengue is also the fastest spreading mosquito-borne viral diseases. Symptoms can range from a mild fever to severe dengue fever with bleeding, accumulation of fluid in the lungs and abdomen, shock and death. Dengue doesnt choose who it affects, anybody can get dengue, whether young or old, woman or man. Health clinic staff and doctors would usually advise patients to drink more water if they are suspected to have dengue fever. Whether this is beneficial or not has not been well studied so far. If oral (by mouth) fluid intake is beneficial, the next question is how to improve the delivery of this advice to dengue patients who come to the primary health care clinics. A simple fluid chart has been designed that patients suspected of having dengue fever should complete every day for as long as they are being followed up by their doctor for the condition. The patient with ...
Dengue Fever - Signs and Symptoms of Dengue Fever - Your Healthy Life OnlineDengue Fever - Signs and Symptoms of Dengue Fever - Your Healthy Life Online
Dengue fever and dengue hemorrhagic fever (DHF) are acute febrile diseases, found in the tropics and Africa, and caused by four closely related virus serotypes of the genus Flavivirus, family Flaviviridae.The geographical spread is similar to malaria, but unlike malaria, dengue is often found in urban areas of tropical nations, including Singapore, Taiwan, Indonesia, Philippines, India and Brazil. Each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. Dengue is transmitted to humans by the Aedes aegypti (rarely Aedes albopictus) mosquito, which feeds during the day.. Dengue (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), of the genus Flavivirus. Infection with one of these serotypes provides immunity to only that serotype for life, so persons living in a dengue-endemic area can have more than ...
Pathophysiological mechanisms of dengue fever: critical review of current concepts]. - RIIP - Réseau International des...Pathophysiological mechanisms of dengue fever: critical review of current concepts]. - RIIP - Réseau International des...
In the 20th century dengue fever became one of the leading causes of morbidity and mortality throughout the tropics. The dengue virus is an arbovirus transmitted by Aedes mosquitoes. There are four distinct serotypes of dengue arbovirus (DENV-1, 2, 3, 4). According to the World Health Organization, a person infected by one of the dengue viruses can develop symptoms ranging from the classical self-limiting form characterized by high temperature, headache, myalgia, and arthralgia to the severe, potentially fatal, form known as dengue shock syndrome. For over 40 years the main explanation for the pathogenesis of dengue has been based on the antibody-dependent enhancement (ADE) concept stating that enhancing antibodies acquired during a primary infection increase the number of infected cells, and thus the level of viremia, during secondary infection. However the severity of dengue is not limited to dengue shock syndrome and there are many cases that do not conform to the ADE concept. A meta-analysis could
Colombia vector borne disease update: Chagas disease, chikungunya, dengue fever and leishmaniasis - Outbreak News TodayColombia vector borne disease update: Chagas disease, chikungunya, dengue fever and leishmaniasis - Outbreak News Today
The Instituto Nacional de Salud reports that through August 29, Colombia has seen 647 accumulated cases of Chagas disease. The vast majority of cases are considered chronic (91%), while the remainder are acute infections.. Boyacá state has reported the most chronic Chagas cases accounting for 18% of the total.. Chikungunya. After reporting a little over 100,000 autochthonous, or indigenous chikungunya cases in 2014, Colombian health authorities have reported 331,366 in 2015 through August.. Virus circulation in Colombia has been demonstrated in 35 territorial entities. To date, 48 chikungunya-related deaths have been reported, with six reported as a co-infection with dengue fever.. Dengue fever. The number of dengue fever cases in Colombia during the first eight months of 2015 is down about 10% compared to the same period last year. To date, 61,451 dengue cases have been reported, including 788 cases of severe dengue. In 2014, 68,884 dengue cases were reported.. 81% of dengue cases came from 11 ...
First dengue vaccine goes under final test in PH | Inquirer BusinessFirst dengue vaccine goes under final test in PH | Inquirer Business
The Philippines and Thailand share a common history when it comes to dengue because it was in these two countries where the dengue hemorrhagic fever, a lethal complication of dengue fever, was first reported and identified in the 1950s.. Fifty-eight years later, dengue fever has become a major international public health concern considering that majority of those affected are children ages between one and 10 years old.. Hospitalized. Though dengue fever is usually not a fatal disease, young patients are more likely to be hospitalized especially if they develop high fever, severe headache, strain in muscles and rashes.. If left unmanaged, dengue fever could kill up to 20 percent of those infected as the patient develops life-threatening conditions like bleeding, low levels of blood platelets and blood plasma leakage (dengue hemorrhagic fever) and circulatory failure (dengue shock syndrome).. According to Dr. Lyndon Lee Suy, program manager of the Department of Healths Emerging and Reemerging ...
Re-assess Vector Indices Threshold as an Early Warning Tool for Predicting Dengue Epidemic in a Dengue Non-endemic Country<...Re-assess Vector Indices Threshold as an Early Warning Tool for Predicting Dengue Epidemic in a Dengue Non-endemic Country<...
TY - JOUR. T1 - Re-assess Vector Indices Threshold as an Early Warning Tool for Predicting Dengue Epidemic in a Dengue Non-endemic Country. AU - Chang, Fong Shue. AU - Tseng, Yao Ting. AU - Hsu, Pi Shan. AU - Chen, Chaur Dong. AU - Lian, Ie Bin. AU - Chao, Day Yu. PY - 2015/9/14. Y1 - 2015/9/14. N2 - Background: Despite dengue dynamics being driven by complex interactions between human hosts, mosquito vectors and viruses that are influenced by climate factors, an operational model that will enable health authorities to anticipate the outbreak risk in a dengue non-endemic area has not been developed. The objectives of this study were to evaluate the temporal relationship between meteorological variables, entomological surveillance indices and confirmed dengue cases; and to establish the threshold for entomological surveillance indices including three mosquito larval indices [Breteau (BI), Container (CI) and House indices (HI)] and one adult index (AI) as an early warning tool for dengue epidemic. ...
WHO | What is dengue?WHO | What is dengue?
Dengue is fast emerging pandemic-prone viral disease in many parts of the world. Dengue flourishes in urban poor areas, suburbs and the countryside but also affects more affluent neighbourhoods in tropical and subtropical countries.. Dengue is a mosquito-borne viral infection causing a severe flu-like illness and, sometimes causing a potentially lethal complication called severe dengue. The incidence of dengue has increased 30-fold over the last 50 years. Up to 50-100 million infections are now estimated to occur annually in over 100 endemic countries, putting almost half of the worlds population at risk.. Severe dengue (previously known as dengue haemorrhagic fever) was first recognized in the 1950s during dengue epidemics in the Philippines and Thailand. Today it affects Asian and Latin American countries and has become a leading cause of hospitalization and death among children and adults in these regions.. The full life cycle of dengue fever virus involves the role of mosquito as a ...
British Library EThOS: Diagnosis and prognosis of severe dengueBritish Library EThOS: Diagnosis and prognosis of severe dengue
Dengue has a broad spectrum of clinical symptoms, ranging from asymptomatic infection, undifferentiated fever and dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). DHF and DSS are the most severe forms of the disease, as they involve bleeding and hypovolemic shock and may lead to death if they are not diagnosed early and treated correctly. Every year, about 36 million cases of DF, of which about 2.1 million cases are DHF/DSS resulting in 21,000 deaths among children and young adults, are reported. Dengue not only has negative effects on public health worldwide but also poses significant economic burden. However, no licensed vaccines or (specific) anti-viral therapies for prevention or treatment of dengue are available. Thus, timely diagnosis and an accurate prognosis of severe dengue in the first few days of illness for clinical triage, treatment management, disease surveillance and research activities are vital and very helpful. We conducted three studies ...
Dengue Epidemic in Brazil | HealthMapDengue Epidemic in Brazil | HealthMap
The Brazilian Ministry of Health has reported 746,000 registered cases of Dengue fever and 229 confirmed deaths since January 2015 [1,3]. This marks a 234% increase in Dengue cases and a 45% increase in Dengue deaths since the previous year [3]. Although nine states are currently experiencing an outbreak of Dengue, more than half of these cases occurred in São Paulo, which also happens to be Brazils most populous state [1]. To date, São Paulo has had three times as many Dengue cases as there were reported in 2014 [1].. Dengue Fever. Dengue fever is a viral disease transmitted to humans through the bite of an infected female mosquito [1-5]. Dengue can be found in tropical and sub-tropical climates across the globe, primarily in urban and semi-urban areas [5]. This places about half of the worlds population at risk [5]. The incubation period for Dengue fever is 4 to 10 days [5]. Symptoms last about 2 to 7 days and include: high fever, severe headache, pain behind the eyes, muscle and joint ...
WHO | Revised SAGE recommendation on use of dengue vaccineWHO | Revised SAGE recommendation on use of dengue vaccine
For countries considering vaccination as part of their dengue control program, a "pre-vaccination screening strategy" would be the preferred option, in which only dengue-seropositive persons are vaccinated.. Conventional serological testing for dengue virus IgG (e.g. dengue IgG ELISA) could be used to identify persons who have had previous dengue infections. Sensitivity and specificity of dengue IgG ELISA should be assessed in a local context, and will depend on the prevalence of other flaviviruses, and past use of flavivirus vaccines (such as Japanese encephalitis and yellow fever vaccines). Currently available rapid diagnostic tests - despite their lower sensitivity and specificity to detect past dengue infection compared with conventional dengue IgG ELISA - could be considered in high transmission settings until better tests are available. In settings with high dengue transmission (high numbers of seropositives), a test with lower specificity might be acceptable.. The pre-test probability of ...
Clinical markers associated with acute laboratory-confirmed Dengue infection: results of a national epidemiological...Clinical markers associated with acute laboratory-confirmed Dengue infection: results of a national epidemiological...
REFERENCES. 1. Simmons CP, Farrar JJ, Nguyen V, Wills B. Dengue. N Engl J Med. 2012; 366(15): 1423-32. [ Links ] 2. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013; 496(7446): 504-7. [ Links ] 3. Hernandez-Avila JE, Rodriguez MH, Santos-Luna R, Sanchez-Castaneda V, Roman-Perez S, Rios-Salgado VH, et al. Nation-wide, web-based, geographic information system for the integrated surveillance and control of dengue fever in Mexico. PLoS One. 2013; 8(8): e70231. [ Links ] 4. Dirección General de Epidemiología. Lineamientos para la vigilancia epidemiológica de dengue por laboratorio. Disponible en: Disponible en: https://goo.gl/qDH4k7 . Consultado en enero de 2017. [ Links ] 5. Hernández-Suárez CM, Mendoza-Cano O. Empirical evidence of the effect of school gathering on the dynamics of dengue epidemics. Global health action. 2016; 9: 28026. [ Links ] 6. World Health Organization. Dengue Haemorrhagic Fever: Diagnosis, ...
Three more dengue cases reported in Karachi - Pakistan News IndexThree more dengue cases reported in Karachi - Pakistan News Index
Karachi: Three more dengue viral fever cases were reported on Thursday, increasing the number of confirmed cases this year to 141, said Focal Person for Dengue Surveillance Cell Dr Shakeel Aamir Mullick.. Dr Mullick said a total of 152 dengue fever cases had so far been reported in 2014, out of which 141 were reported in Karachi, two in Hyderabad and six in the rest of Sindh. He said three dengue cases were also reported from Balochistan province.. He said that a dengue patient had expired in city this year so far. He said three new dengue fever cases were reported (03OPD) 27th March 2014.. ...
PLOS Neglected Tropical Diseases: Forecast of Dengue Incidence Using Temperature and RainfallPLOS Neglected Tropical Diseases: Forecast of Dengue Incidence Using Temperature and Rainfall
Author Summary Without effective drugs or a vaccine, vector control remains the only method of controlling dengue fever outbreaks in Singapore. Based on our previous findings on the effects of weather on dengue cases and optimal timing for issuing dengue early warning in Singapore, the purpose of this study was to develop a dengue forecasting model that would provide early warning of a dengue outbreak several months in advance to allow sufficient time for effective control to be implemented. We constructed a statistical model using weekly mean temperature and rainfall. This involved 1) identifying the optimal lag period for forecasting dengue cases; 2) developing the model that described past dengue distribution patterns; 3) performing sensitivity tests to analyze whether the selected model could detect actual outbreaks. Finally, we used the selected model to forecast dengue cases from 2011-2012 week16 using weather data alone. Our model forecasted for a period of 16 weeks with high sensitivity in
PLOS Neglected Tropical Diseases: Forecast of Dengue Incidence Using Temperature and RainfallPLOS Neglected Tropical Diseases: Forecast of Dengue Incidence Using Temperature and Rainfall
Author Summary Without effective drugs or a vaccine, vector control remains the only method of controlling dengue fever outbreaks in Singapore. Based on our previous findings on the effects of weather on dengue cases and optimal timing for issuing dengue early warning in Singapore, the purpose of this study was to develop a dengue forecasting model that would provide early warning of a dengue outbreak several months in advance to allow sufficient time for effective control to be implemented. We constructed a statistical model using weekly mean temperature and rainfall. This involved 1) identifying the optimal lag period for forecasting dengue cases; 2) developing the model that described past dengue distribution patterns; 3) performing sensitivity tests to analyze whether the selected model could detect actual outbreaks. Finally, we used the selected model to forecast dengue cases from 2011-2012 week16 using weather data alone. Our model forecasted for a period of 16 weeks with high sensitivity in
Dengue: Methods and Protocols by Radhakrishnan Padmanabhan and Subhash G. Vasudevan"Dengue: Methods and Protocols" by Radhakrishnan Padmanabhan and Subhash G. Vasudevan
Infection by flaviviruses such as dengue virus serotypes (DENV 1-4), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBE), yellow fever virus (YFV) and West Nile virus (WNV) impact millions of lives and cause tens of thousands of mortalities each year. Dengue is a global public health emergency especially since there is no preventative vaccine or antiviral treatment for dengue disease. Dengue: Methods and Protocols offers the increasing number of dengue researchers a one-stop protocol book with techniques compiled from the leading laboratories working on dengue. Chapters cover topics such as dengue virus isolation from clinical samples, quantification of human antibodies against the virus, assays to quantify the virus particles, the widely used mouse model to study dengue pathogenesis, vaccine and antiviral efficacies. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and
Table 2 - Dengue Surveillance in Florida, 1997-98 - Volume 6, Number 1-February 2000 - Emerging Infectious Disease journal - CDCTable 2 - Dengue Surveillance in Florida, 1997-98 - Volume 6, Number 1-February 2000 - Emerging Infectious Disease journal - CDC
Recent dengue outbreaks in the Caribbean and Central and South America and the presence of competent mosquito vectors increase the likelihood of future autochthonous transmission in Florida. During April 1997 to March 1998, a laboratory-based active surveillance program detected 18 cases of dengue involving all four dengue serotypes. All patients reported recent travel to countries with indigenous dengue transmission. These results demonstrate that dengue infections are imported into Florida at a much higher rate than reflected by previous passive surveillance; therefore, the risk for local dengue transmission may be increasing.
Should you buy a dengue health insurance plan? - DroidooShould you buy a dengue health insurance plan? - Droidoo
We all hear about the rising cases of dengue, chikungunya, malaria due to the breeding of mosquitoes in the monsoon season. According to the civic bodies, the National Capital Region has reported 284 new dengue cases in the last ten days, taking the total to 771. There were around 50,000 dengue cases which were reported last year.. India has observed a 14 times increase in the number of dengue cases reported between 2007 and 2013 (as per National Vector Borne Disease Control Programme) with symptoms that require hospitalisation for its treatment. Such rise in dengue cases has resulted in an increase in the health insurance claims in past years as per the insurers.. What is dengue?. Dengue or break-bone fever is a mosquito-borne viral disease which is mainly found in the tropical and subtropical countries. This disease is caused by one of the four related dengue viruses and is an infectious disease. It is a life-threatening disease, and there is no vaccination or drug available to cure the ...
Dengue Prevention<...Dengue Prevention<...
Get Dengue Prevention latest information and updates. Read latest Dengue Prevention articles, watch Dengue Prevention videos and much more at NDTV Food
HLA-B*44 is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population - CBGSEHLA-B*44 is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population - CBGSE
Abstract: Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations. We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 infection and confirmed clinical diagnosis of either severe dengue, known as dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in Recife, Pernambuco, Brazil. An association analysis was performed using Fishers association test, with odds ratios (ORs) calculated using conditional maximum likelihood estimates. HLA-B*44 (P=0.047, OR = 2.025, 95% CI = 0.97-4.24) was found to be associated with increased susceptibility to DHF in response to DENV-3 infection. In addition, HLA-B*07 (P=0.048, OR = 0.501, one-sided 95% CI = 0-0.99) and HLA-DR*13 (P=0.028, OR = 0.511, one-sided 95% CI = 0-0.91) were found to be associated with resistance to secondary dengue ...
A review of dengue diagnostics and implications for surveillance and control. - MORU Tropical Health NetworkA review of dengue diagnostics and implications for surveillance and control. - MORU Tropical Health Network
Dengue is the worlds most common arboviral infection, with almost 4 billion people estimated to be living at risk of dengue infection. A recently introduced vaccine is currently recommended only for seropositive individuals in a restricted age range determined by transmission intensity. With no effective dengue vaccine for the general population or any antiviral therapy, dengue control continues to rely heavily on vector control measures. Early and accurate diagnosis is important for guiding appropriate management and for disease surveillance to guide prompt dengue control interventions. However, major uncertainties exist in dengue diagnosis and this has important implications for all three. Dengue can be diagnosed clinically against predefined lists of signs and symptoms and by detection of dengue-specific antibodies, non-structural 1 antigen or viral RNA by reverse transcriptase-polymerase chain reaction. All of these methods have their limitations. This review aims to describe and quantify the
Liver dysfunction in Dengue infection: an analysis of the previously published Thai cases. - Semantic ScholarLiver dysfunction in Dengue infection: an analysis of the previously published Thai cases. - Semantic Scholar
BACKGROUND Dengue infection is a major vector-borne disease. The classical sings and symptoms of this infection include high fever, violent headache, chill and rash. However, there are a number of atypical forms of dengue infection including those presented with liver dysfunction. However, there are only a few reports concerning the liver dysfunction among the patients with dengue infections. METHODS Here, the author presents a summative study on the liver dysfunction and its clinical correlation among Thai patients in the previous studies. A literature review on the prospective studies concerning liver function and dengue infection in Thailand was performed. RESULTS According to this study, there are 4 reports included covering 191 Thai pediatric patients with dengue infection. The overall rate of liver dysfunction among 191 subjects is 34.6 % (66/191). The rate of liver dysfunction among the patients without shock (36/120) is not significant different from those with shock. The rate of liver
Dengue Fever News, ResearchDengue Fever News, Research
Dengue (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), of the genus Flavivirus. Infection with one of these serotypes provides immunity to only that serotype for life, so persons living in a dengue-endemic area can have more than one dengue infection during their lifetime. DF and DHF are primarily diseases of tropical and sub tropical areas, and the four different dengue serotypes are maintained in a cycle that involves humans and the Aedes mosquito. However, Aedes aegypti, a domestic, day-biting mosquito that prefers to feed on humans, is the most common Aedes species. Infections produce a spectrum of clinical illness ranging from a nonspecific viral syndrome to severe and fatal hemorrhagic disease. Important risk factors for DHF include the strain of the infecting virus, as well as the age, and especially the prior dengue infection history of the patient ...
Press Release - Senate OKs P1.16 B supplemental DOH budget to help dengue patientsPress Release - Senate OKs P1.16 B supplemental DOH budget to help dengue patients
The Senate today approved on third and final reading a bill seeking to appropriate a P1.16 billion supplemental budget for the Department of Health (DOH) this year to fund medical assistance programs for dengue patients in the country.. House Bill No. 7449, sponsored by Senator Loren Legarda, chairperson of the Senate Committee on Finance and co-sponsored by Senator Richard Gordon, was approved with 18 affirmative votes, zero negative vote and no abstention.. According to Legarda, the supplemental budget of P1,161,710,000 for the DOH would be used exclusively to fund medical assistance programs for dengue patients, including those who are confined or are outpatients.. "The above allocation will also be used to provide medical assistance for hospitalization, out-patient care services, procurement of supplies and medicine," she said.. The supplemental budget, Legarda said, would provide help and "allay the fears" of the almost 900,000 individuals, both children and adults, who were administered ...
FDA approves the first vaccine for Dengue preventionFDA approves the first vaccine for Dengue prevention
The U.S. Food and Drug Administration has granted approval to first vaccine approved vaccine for Dengue prevention -Dengvaxia.The vaccine prevents against dengue disease caused by all dengue virus serotypes (1, 2, 3 and 4) in people ages 9 through 16 who have laboratory-confirmed previous dengue infection and who live in endemic areas.
Dengue Hemorrhagic Fever: Hopes for an Effective Vaccine?Dengue Hemorrhagic Fever: Hopes for an Effective Vaccine?
Dengue is not transmitted directly from person-to-person. Instead, it is transmitted by the bite of a mosquito infected with one of the four dengue virus serotypes. It is a febrile illness that affects infants, young children and adults. Symptoms range from mild fever to incapacitating high fever with rash, severe headache, pain behind the eyes, as well as muscle and joint pain. The disease is also known as "breakbone fever" due to the severe pain it can cause. Severe dengue (also known as dengue hemorrhagic fever) affects mainly children, and is characterized by fever, abdominal pain, persistent vomiting, bleeding and breathing difficulty - it is potentially deadly.. The WHO estimates that about half of the worlds population is now at risk. However, at this time, there is no licensed vaccine or any specific medicine to treat dengue. Fortunately, there is hope. Several vaccines are in the final steps of development, with the one produced by the French pharmaceutical company Sanofi Pasteur ...
The Serious Business Of Dengue Prevention - miyagi.sgThe Serious Business Of Dengue Prevention - miyagi.sg
The other thing Im concerned with is that many of us delegate our household chores to our hired help, and dengue prevention tasks like the 5-Step Mozzie Wipeout may be one of the chores that can be overlooked at times. Im quite keen to make sure that this is done myself even if we have help at home.. For us, dengue prevention is a serious business, as Ive reminded everyone over the years, our now 7-year-old son had to have two blood transfusions at 8 weeks old due to dengue fever. So hes going to go around our apartment and do the Mozzie Wipeout with me regularly as well.. Its no joke - there have been more than 5,900 reported cases of dengue since the beginning of the year. So get on it now, and make the Mozzie Wipeout part of your household routine.. ...
Pakistan to get insecticide from India to fight dengue | TopNewsPakistan to get insecticide from India to fight dengue | TopNews
Islamabad, Sep 21 - Prime Minister Yousuf Raza Gilani has directed Pakistan International Airlines (PIA) to lift insecticides from India for the prevention of dengue.. The insecticide has to be got from Mumbai.. There has been a rise in dengue cases in Pakistan, with Punjab province reporting over 6,000 dengue patients. About 35 people have died due to dengue.. The insecticides were purchased by the Punjab government.. The PIA was reluctant to airlift the insecticide due to rules which prohibit the transportation of the material of this nature, the Associated Press of Pakistan reported.. The prime ministers instructions led to a waiver due to the dengue epidemic.. Gilani had said that the country needs to develop a national coordination mechanism for controlling epidemics like dengue.. Dengue fever is caused by a virus transmitted by the aedes aegypti mosquito. Symptoms include fever, headache, muscle and joint pains and a skin rash similar to measles. Patients suffer from bleeding and low ...
High Producing Tumor Necrosis Factor Alpha Gene Alleles in Protection against Severe Manifestations of Dengue [Abstract]High Producing Tumor Necrosis Factor Alpha Gene Alleles in Protection against Severe Manifestations of Dengue [Abstract]
Abstract. Dengue virus (DENV) infection usually presents with mild self-limiting dengue fever (DF). Few however, would present with the more severe form of the disease, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). In the present study, the association between IL-12B, IL-10 and TNF-α gene polymorphisms and dengue severity was investigated. Methods: A case-control study was performed on a total of 120 unrelated controls, 86 DF patients and 196 DHF/DSS patients. The polymorphisms in IL-12B, IL-10 and TNF-α genes were genotyped using PCR-RFLP and PCR-sequencing methods. Results: A protective association of TNF-α -308A allele and -308GA genotype against DHF/DSS was observed, while TNF-α -238A allele and -238GA genotype were associated with DHF/DSS. A combination of TNF-α -308GA+AA genotype and IL-10 non-GCC haplotypes, IL-12B pro homozygotes (pro1/pro1, pro2/pro2) and IL-12B 3UTR AC were significantly correlated with protective effects against DHF/DSS. An association between ...
International Research Consortium on Dengue Risk Assessment, Management, and Surveillance - Full Text View - ClinicalTrials.govInternational Research Consortium on Dengue Risk Assessment, Management, and Surveillance - Full Text View - ClinicalTrials.gov
Improvements in diagnosis of dengue fever and prediction of which patients will get more severe disease are urgently needed to improve the treatment of patients with dengue. This is very important in places with many people who suffer from dengue but have limited health care resources. This study will enroll patients with fever which may be caused by dengue in 6 countries with high incidence of dengue over two continents (Brazil, Cambodia, El Salvador, Indonesia, Malaysia and Vietnam). All patients will be followed by a doctor with blood tests and exams until they recover. Symptoms and laboratory tests will be followed so that the cause of fever can be determined. For patients who have dengue, the investigators will look for symptoms and tests which indicate more serious disease. This study will help to determine how to identify patients with dengue fever based on symptoms and simple laboratory tests and those who will get more serious disease. It will also help to define a more standardized ...
H5N1: Australia: Cairns dengue fever cases hit 59H5N1: Australia: Cairns' dengue fever cases hit 59
Via ABC News: Cairns dengue fever cases hit 59. Queensland Health says the far norths wet weather is hampering efforts to contain a dengue fever outbreak in Cairns. Fifty-nine cases of the mosquito-borne virus have now been confirmed in Cairns...
Dissecting Japans Dengue Outbreak in 2014Dissecting Japan's Dengue Outbreak in 2014
Background Dengue is a significant problem of international health concern. According to the World Health Organization in 2012, globally, dengue is "the most important mosquito borne viral disease" with incidence 30 higher than it had been 50 years ago. While most of the burden of disease associated with dengue is located in areas with a tropical and sub-tropical climate, increasing evidence suggests temperate areas are also at risk. Considering the recent introduction of relevant mosquito vectors into Southern Europe, and increasing numbers of imported dengue via travelers, Europe and other temperate areas may be increasingly at risk for dengue emergence, establishment and local transmission in the foreseeable future.. Methods Recent dengue emergence in Madeira and reemergence in Tokyo underline the hypothesis that passenger air-travel can be an important conduit for the importation of vector-borne disease leading to emergence in naïve areas climatically suitable for dengue transmission, ...
Dengue fever | Can we treat dengue in Home | What to do in Dengue feverDengue fever | Can we treat dengue in Home | What to do in Dengue fever
This article is explaining all the aspects of dengue fever including Signs and symptoms of dengue, treatment and home remedies for dengue, vaccines for dengue, Transmission, types of viruses, types of mosquitoes who causing dengue fever, etc..
Safety of and Immune Response to Two Different Dengue Virus Vaccines in Individuals Previously Immunized Against Dengue Virus -...Safety of and Immune Response to Two Different Dengue Virus Vaccines in Individuals Previously Immunized Against Dengue Virus -...
The World Health Organization estimates that dengue virus causes more than 50 million cases of dengue fever a year. Dengue virus infection is the leading cause of hospitalization and death in children of most tropical Asian countries. There are four different serotypes of dengue virus. Most cases of dengue hemorrhagic fever/dengue shock syndrome are caused by secondary infection with a dengue serotype different from the first serotype the individual was infected with. A vaccine that would be effective in preventing infection by multiple dengue serotypes is desirable. The purpose of this study is to determine the safety of and immune response to two different dengue virus vaccines in individuals who have been previously vaccinated against a different serotype.. This study will last at least 42 days. Participants will be recruited from a database of previous dengue vaccine recipients and will be stratified by the type of vaccine previously received. Participants assigned to Cohort 1 and Cohort 2 ...
Antibody-dependent enhancement of dengue virus infection mediated by bispecific antibodies against cell surface molecules other...Antibody-dependent enhancement of dengue virus infection mediated by bispecific antibodies against cell surface molecules other...
It is known that antibodies to dengue viruses at subneutralizing concentrations enhance dengue virus infection of Fc gamma R+ cells. This phenomenon called antibody-dependent enhancement (ADE) occurs when virus-antibody complexes bind to the Fc gamma R via the Fc portion of the Ig. It has been hypothesized that ADE may be responsible for the pathogenesis of the severe manifestations of dengue virus infection including dengue hemorrhagic fever/dengue shock syndrome. To further analyze the mechanisms of ADE, we prepared bispecific antibodies by chemically cross-linking antidengue virus antibodies to antibodies specific for Fc gamma RI or Fc gamma RII and the non-Fc R molecules beta2 microglobulin, CD15 or CD33 and examined whether these bispecific antibodies could enhance infection. Bispecific antibodies targeting dengue virus to Fc gamma RI or Fc gamma RII enhanced dengue virus infection, consistent with previous reports using conventional antibodies. Furthermore, bispecific antibodies targeting ...
Tropical feverTropical fever
Dengue virus is a human pathogen that causes dengue fever, which can either resolve after mild fever or lead to severe dengue hemorrhagic fever/dengue shock syndrome. The role of dengue virus levels in the blood and the kinetics of infection and immune response that results in severe dengue disease in humans is not well characterized. In this study, we analyzed 97 children with varying degrees of dengue disease, and we show that the dengue virus quantity in blood does not show any significant association with severe disease. However, most severe dengue patients had lower levels of interferons and Th1 cytokines and increased levels of secreted factors such as IL-6, IL-8 and IL-10 that could potentially cause leakage in blood capillaries. Our results indicate that monocytes, which are infected with dengue virus in patients, could possibly play a major role in dengue pathogenesis. Furthermore, using computational analysis we identified association of some of the secreted factors with severe disease ...
Davidson, A. D.<...Davidson, A. D.<...
The dengue viruses are spread by mosquitoes and infect up to 390 million individuals annually in sub-tropical and tropical regions of the world. Dengue disease has emerged as the most important arthropod-borne viral disease of humans. Dengue virus infection generally results in dengue fever, a debilitating but self limited febrile disease. However, complications may arise, leading to the potentially fatal dengue haemorrhagic fever/dengue shock syndromes (DHF/DSS). Despite intensive research over recent years, the pathogenesis of DHF/DSS is still poorly understood and there is neither a safe and effective vaccine nor suitable anti-viral treatments to control dengue disease.. Current investigations in the laboratory focus on understanding the role of specific viral proteins in the virus lifecycle and the role they play in perturbing host cellular processes. Our studies use a dengue virus reverse genetic system, in combination with structural, biochemical and high throughput transcriptomic and ...
Dengue Vaccine Development - Global Dengue & Aedes-Transmitted Diseases Consortium (GDAC)Dengue Vaccine Development - Global Dengue & Aedes-Transmitted Diseases Consortium (GDAC)
In the absence of truly effective and sustainable vector control measures, a dengue vaccine is urgently needed. While dengue vaccines have been under development since the 1940s, due to the limited appreciation of global dengue disease burden and of the potential markets for dengue vaccines, the industrys interest languished throughout much of the 20th century.. In recent years, however, the development of dengue vaccines has accelerated dramatically. Sanofi Pasteurs Dengvaxia® became the first dengue vaccine to be licensed for use in 2015. Today, several other vaccines are in various stages of advanced development, with clinical trials currently underway.. Vaccine development for dengue is particularly challenging because dengue fever is caused by any of four related, but distinct, virus serotypes (DENV-1-4). While infection by one virus provides lifelong immunity against that serotype, it provides only partial and transient immunity against the other three. This means that an effective ...
Change in Dengue and Japanese Encephalitis Seroprevalence Rates in Sri Lanka. - Radcliffe Department of MedicineChange in Dengue and Japanese Encephalitis Seroprevalence Rates in Sri Lanka. - Radcliffe Department of Medicine
BACKGROUND: Sri Lanka has been affected by epidemics of dengue infections for many decades and the incidence and severity of dengue infections have been rising each year. Therefore, we investigated the age stratified seroprevalence of dengue infections in order to facilitate future dengue vaccine strategies. In addition, since the symptomatic dengue infections have increased during the past few decades, we also investigated the possible association with Japanese Encephalitis Virus (JEV) antibody seropositivity with symptomatic dengue in a community cohort in Sri Lanka. METHODS: 1689 healthy individuals who were attending a primary health care facility were recruited. Dengue and JEV antibody status was determined in all individuals and JEV vaccination status was recorded. RESULTS: 1152/1689 (68.2%) individuals were seropositive for dengue and only 133/1152 (11.5%) of them had been hospitalized to due to dengue. A significant and positive correlation was observed for dengue antibody seropositivity and age
TravelSafe Clinic - Travel Health, Yellow Fever Disease & Vaccination.: New Dengue Vaccine from Sanofi shows promising efficacy...TravelSafe Clinic - Travel Health, Yellow Fever Disease & Vaccination.: New Dengue Vaccine from Sanofi shows promising efficacy...
The NEJM article reported results from a new pooled efficacy analysis of individuals 9 years of age and older at vaccination from the two Phase III studies of Sanofi Pasteurs dengue vaccine. The new analysis documented that the vaccine protects two-thirds of these individuals (66%) against dengue, providing even greater protection against two clinically relevant manifestations of dengue, namely severe dengue (93%) and prevention of hospitalizations due to dengue (80%) that account for the greatest human and economic burden of dengue in endemic countries. In addition, the dengue vaccine candidate protected volunteers 9 years of age and older who were previously exposed to dengue (82%), as well as those who were naïve to dengue (52.5%) prior to vaccination ...
Welcome to CDC stacks | The transmission of dengue fever in Puerto Rico : an epidemiologic approach using a Geographic...Welcome to CDC stacks | The transmission of dengue fever in Puerto Rico : an epidemiologic approach using a Geographic...
Dengue fever, a viral disease transmitted by the mosquito Aedes aegypti, can spread rapidly in explosive epidemics. In Puerto Rico, dengue is a seasonal disease estimated to be responsible for more than 1,000 hospitalizations annually. Dengue transmission is influenced by the behavior of Aedes aegypti, movement and distribution of humans, and virus development within the mosquito. The role of each of these factors is poorly understood, in part, because of the absence of studies on the spatialtemporal patterns of dengue cases. Furthermore, recent failures of mosquito control programs designed to reduce dengue transmission indicate that long standing assumptions about the dispersal of dengue virus by mosquitoes are incorrect. The spatial and temporal distribution of dengue cases reported to the Centers for Disease Controls dengue surveillance system during a 1991-92 outbreak in Florida, Puerto Rico, and a normal transmission season (May 1994 - June 1995) in Ponce, Puerto Rico, were studied using ...
Dengue hemorrhagic feverDengue hemorrhagic fever
Medical information, Dengue hemorrhagic fever. Definition of Dengue hemorrhagic fever, symptoms of Dengue hemorrhagic fever, treatment of Dengue hemorrhagic fever, and prevention of Dengue hemorrhagic fever. Exams and Tests Dengue hemorrhagic fever.
Biology-OnlineBiology-Online
Research recently published in PLoS Medicine challenges the dogma of the antibody-dependent enhancement model (ADE) for the development of dengue hemorrhagic fever (DHF). Dengue virus infection usually causes a severe flu like illness, although symptoms may be mild in young children. DHF, however, is a severe and sometimes fatal complication of dengue virus infection that affects about half a million people every year. DHF patients usually fall into two groups; children and adults who become infected with a second dengue virus serotype after an initial primary dengue virus infection with a different serotype, and infants with primary dengue virus infections born to mothers who have some dengue virus immunity. The current model for development of DHF in infants around 6 months old is that anti-dengue virus antibodies transferred from a dengue-immune mother to her child somehow enhance dengue virus infection, resulting in more severe symptoms (the antibody-dependent enhancement model). A ...
H5N1: Dengue fever cases in Vanuatu now over 300H5N1: Dengue fever cases in Vanuatu now over 300
Via Radio New Zealand: Dengue fever cases in Vanuatu now over 300. Vanuatus Ministry of Health says the number of confirmed dengue fever cases in the country has climbed to 313. At the end of last month the number of...
one step dengue antigen rapid rapid test kitone step dengue antigen rapid rapid test kit
Dengue IgG one step dengue antigen rapid rapid test kit IgM Ab Rapid Test Kit One Step Diagnosis Blood Testing. The Dengue IgG one step dengue antigen rapid rapid test kitIgM Ab Rapid Test Cassette (Whole Blood one step dengue antigen rapid rapid test kitSerum one step dengue antigen rapid rapid test kitPlasma) is a qualitative membrane-based immunoassay for the detection of Dengue antibodies in whole blood, serum, or plasma. The Dengue IgG one step dengue antigen rapid rapid test kitIgM Ab Rapid Test Cassette (Whole Blood one step dengue antigen rapid rapid test kit Serum one step dengue antigen rapid rapid test kit Plasma) is a qualitative membrane-based immunoassay for the ...
2019-1332019-133
Dengue virus infection is one of the most common mosquito-borne illnesses worldwide, with nearly four billion people living in at risk areas throughout the world. Reported cases to World Health Organization continue to rise exponentially with an estimated 50 - 100 million symptomatic cases, mostly in Asia. Most clinical cases present with a self-limited viral illness, but some experience life-threatening severe disease. Four serotypes of dengue virus exist; infection by one serotype confers long lasting homotypic immunity, but does not confer heterotypic immunity to another serotype. Subsequent infection from a different dengue serotype can lead to the development of severe dengue. Antibody-dependent enhancement of dengue virus infection has been implicated in the development of severe disease. There have been various efforts to develop vaccines against dengue, including subunit vaccines that use only the viral envelope glycoprotein, or portions thereof. Those efforts are hampered by the ...
The exploration of risk factors of concurrent bacteraemia in patients critically ill with severe dengue<...The exploration of risk factors of concurrent bacteraemia in patients critically ill with severe dengue<...
TY - JOUR. T1 - The exploration of risk factors of concurrent bacteraemia in patients critically ill with severe dengue. AU - Chen, Chin Ming. AU - Chan, Khee Siang. AU - Cheng, Kuo Chen. AU - Chou, Willy. AU - Chao, Hui Chun. AU - Yeh, Chiu Yin. AU - Yu, Wen Liang. PY - 2016/12/1. Y1 - 2016/12/1. N2 - We investigated the clinical features of intensive care unit (ICU) patients with concomitant severe dengue infection and bacteraemia to identify risk factors for this comorbidity. The records of all ICU dengue patients admitted during the period of 31 July-30 November 2015 were reviewed. Patients with concurrent bacteremia (positive bacterial blood culture within 72 h of ICU admission) were identified. ICU admission was required for 142 patients, of which 22 (15.5%) had concurrent bacteraemia. Species of the genus Streptococcus was the most common pathogens, followed by Escherichia coli then species of the genus Staphylococcus. Patients with a severe dengue infection and bacteraemia had higher ...
Evaluation of the WHO 2009 classification for diagnosis of acute dengue in a large cohort of adults and children in Sri Lanka...Evaluation of the WHO 2009 classification for diagnosis of acute dengue in a large cohort of adults and children in Sri Lanka...
The new WHO 2009 classification of dengue divides suspected cases into three categories: dengue without warning signs, dengue with warning signs and severe dengue. We evaluated the WHO 2009 classification vs physicians subjective clinical diagnosis (gestalt clinical impression) in a large cohort of patients presenting to a tertiary care center in southern Sri Lanka hospitalized with acute febrile illness. We confirmed acute dengue in 388 patients (305 adults ≥ 18 years and 83 children), including 103 primary and 245 secondary cases, of 976 patients prospectively enrolled with AFI. At presentation, both adults and children with acute dengue were more likely than those with other AFI to have leukopenia and thrombocytopenia. Additionally, adults were more likely than those with other AFI to have joint pain, higher temperatures, and absence of crackles on examination whereas children with dengue were more likely than others to have sore throat, fatigue, oliguria, and elevated hematocrit and ...
Reversible splenial lesion syndrome associated with dengue fever: a case report | BMC Research Notes | Full TextReversible splenial lesion syndrome associated with dengue fever: a case report | BMC Research Notes | Full Text
Dengue virus infection in humans can lead to a wide range of clinical manifestations, from mild fever to potentially fatal dengue shock syndrome. The incidence of dengue fever is on the rise in tropical countries. Due to the increasing incidence of dengue fever worldwide, atypical manifestations of the disease are increasingly reported. In this article we report a patient with dengue haemorrhagic fever who presented with reversible splenial lesion syndrome. A 24-year-old Sri Lankan man who presented with fever and confusion was eventually diagnosed to have reversible splenial lesion syndrome based on brain imaging. Clinical, serological and haematological parameters confirmed a diagnosis of dengue haemorrhagic fever. His presentation, assessment, and management are described in this case report. Reversible splenial lesion syndrome is a condition which is radiologically characterized by reversible lesion in the splenium of the corpus callosum. It is associated with infectious and non-infectious
Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes. | Journal of...Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes. | Journal of...
Although endothelial cells have been speculated to be a target in the pathogenesis of dengue hemorrhagic fever (DHF), there has been little evidence linking dengue virus infection to any alteration in endothelial cell function. In this study, we show that human umbilical vein endothelial cells become activated when exposed to culture fluids from dengue virus-infected peripheral blood monocytes. Maximum activation was achieved with culture fluids from monocytes in which virus infection was enhanced by the addition of dengue virus-immune serum, thus correlating with epidemiological evidence that prior immunity to dengue virus is a major risk factor for DHF. Activation was strongest for endothelial cell expression of VCAM-1 and ICAM-1. In contrast, activation of endothelial cell E-selectin expression appeared to be more transient, as indicated by its detection at 3 h, but not at 16 h, of treatment. Treatment of monocyte culture fluids with anti-tumor necrosis factor alpha (TNF-alpha) antibody ...
Dandy fever | definition of dandy fever by Medical dictionaryDandy fever | definition of dandy fever by Medical dictionary
Looking for online definition of dandy fever in the Medical Dictionary? dandy fever explanation free. What is dandy fever? Meaning of dandy fever medical term. What does dandy fever mean?
High prevalence of previous dengue virus infection among first-generation Surinamese immigrants in the Netherlands | BMC...High prevalence of previous dengue virus infection among first-generation Surinamese immigrants in the Netherlands | BMC...
In this study the prevalence of dengue virus IgG antibodies among first-generation Surinamese immigrants was 81%. Although seroprevalence studies among Surinamese inhabitants are not available, this is comparable with the results from seroprevalence studies among populations in Latin America [10-13]. It seems like immigration to a non dengue endemic country causes little difference in dengue seroprevalence between the Surinamese immigrants and the majority of populations living in dengue-endemic areas of the Americas and the Caribbean get infected with the dengue virus.. As expected, the seroprevalence of previous DENV infection in our study was positively related to the duration participants had lived in Suriname before immigration. This is in line with studies performed among persons living in dengue-endemic countries in Latin America where they found higher seroprevalence rates of DENV antibodies by increasing age, which can be seen as a marker for duration of exposure [13, 14].. A limitation ...
Notes from the Field: School Reporting of a Dengue Outbreak - St. Croix, U.S. Virgin Islands, 2012Notes from the Field: School Reporting of a Dengue Outbreak - St. Croix, U.S. Virgin Islands, 2012
Dengue is endemic in the U.S. Virgin Islands, but no outbreaks have been reported since 2005 (1). In November 2012, a school nurse in St. Croix reported suspected dengue in 27 (7%) of 369 students and staff members to the Virgin Islands Department of Health (VIDOH) and the CDC Dengue Branch in Puerto Rico. Four of 12 patient specimens sent to the CDC Dengue Branch for diagnostic testing were confirmed as dengue. Although VIDOH had observed an increase in passive dengue reporting, reliable baseline case counts were unavailable for comparison. An investigation was begun to determine the incidence of recent dengue virus (DENV) infection in schools and islandwide. A seroincidence study was conducted at six schools in addition to the index school, using a stratified two-stage cluster sampling methodology. Of 320 participants, 40 (20%) of 203 students and 20 (17%) of 118 staff members were immunoglobulin M (IgM) anti-DENV positive, indicating DENV infection within the preceding 3 months. Four students ...
The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model | BMC...The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model | BMC...
Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted in any clinical and in vivo studies. The aim of this study is to investigate the effect of freeze-dried CPLJ treatment on NS1 and viremia levels of dengue fever mouse model. The dengue infection in mouse model was established by inoculation of non-mouse adapted New Guinea C strain dengue virus (DEN-2) in AG129 mice. The freeze-dried CPLJ compounds were identified by Ultra-High Performance Liquid Chromatography High Resolution Accurate Mass Spectrometry analysis. The infected AG129 mice were orally treated with 500 mg/kg/day and 1000 mg/kg/day of freeze-dried CPLJ, starting on day 1 post infection for 3 consecutive days. The blood samples were collected from submandibular vein for plasma NS1 assay and
The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model | BMC...The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model | BMC...
Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted in any clinical and in vivo studies. The aim of this study is to investigate the effect of freeze-dried CPLJ treatment on NS1 and viremia levels of dengue fever mouse model. The dengue infection in mouse model was established by inoculation of non-mouse adapted New Guinea C strain dengue virus (DEN-2) in AG129 mice. The freeze-dried CPLJ compounds were identified by Ultra-High Performance Liquid Chromatography High Resolution Accurate Mass Spectrometry analysis. The infected AG129 mice were orally treated with 500 mg/kg/day and 1000 mg/kg/day of freeze-dried CPLJ, starting on day 1 post infection for 3 consecutive days. The blood samples were collected from submandibular vein for plasma NS1 assay and
The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model | BMC...The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model | BMC...
Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted in any clinical and in vivo studies. The aim of this study is to investigate the effect of freeze-dried CPLJ treatment on NS1 and viremia levels of dengue fever mouse model. The dengue infection in mouse model was established by inoculation of non-mouse adapted New Guinea C strain dengue virus (DEN-2) in AG129 mice. The freeze-dried CPLJ compounds were identified by Ultra-High Performance Liquid Chromatography High Resolution Accurate Mass Spectrometry analysis. The infected AG129 mice were orally treated with 500 mg/kg/day and 1000 mg/kg/day of freeze-dried CPLJ, starting on day 1 post infection for 3 consecutive days. The blood samples were collected from submandibular vein for plasma NS1 assay and
What is the immunopathology of severe dengue (dengue hemorrhagic fever)?What is the immunopathology of severe dengue (dengue hemorrhagic fever)?
The immunopathology of severe dengue remains incompletely understood. Most patients who develop severe dengue have had prior infection with one or more dengue serotypes. When an individual is infected... more
What is the immunopathology of severe dengue (dengue hemorrhagic fever)?What is the immunopathology of severe dengue (dengue hemorrhagic fever)?
The immunopathology of severe dengue remains incompletely understood. Most patients who develop severe dengue have had prior infection with one or more dengue serotypes. When an individual is infected... more
Dengue vaccine can be dangerous for those not previously infected, says manufacturer - SgLinks.comDengue vaccine can be dangerous for those not previously infected, says manufacturer - SgLinks.com
SINGAPORE - Dengvaxia, a dengue vaccine available here since March, could prove detrimental to people who have never been infected by dengue. Sanofi, which produces the vaccine, sent out an alert saying: For those not previously infected by dengue virus, the analysis found that in the longer term, more cases of severe disease could occur following vaccination upon a subsequent dengue infection. The French pharmaceutical giant said it will ask the health authorities in countries where it has been approved for use, such as in Singapore, to update their information on the vaccine. A spokesman for the Health Sciences Authority (HSA) said on Thursday (Nov 30) that it is working with Sanofi Pasteur to strengthen the package insert to include the warning of an increased risk of hospitalisation for dengue and clinically severe dengue in vaccinated individuals not previously in... Full article: http://www.straitstimes.com/singapore/health/dengue-vacci... ...
Dengue VaccineDengue Vaccine
Dengue is a mosquito-borne flavivirus disease found mostly in tropical and some subtropical areas. It is caused by four related viruses. To date, there is no specific treatment for the disease and prevention is limited to vector control measures.. The quest for a dengue vaccine has been ongoing since 1929 but because of incomplete knowledge about the disease and the complication of targeting all four dengue serotypes, development of an effective vaccine has proven to be quite difficult.. Although you can get vaccinated from other diseases in our New York travel medicine clinic, there is no licensed vaccine available for dengue yet. It is believed that a vaccine would play a major role in controlling this disease and could help the World Health Organization achieve its goal of reducing dengue morbidity by at least 20 percent and mortality by 50 percent by 2020.. However, there are some vaccine candidates that are currently under development. Sanofi Pasteur is developing a live attenuated ...
Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity | Science...Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity | Science...
Everyone knows how mosquitos can wreck an end-of-summer picnic. But in some climates, these pesky intruders persist and carry a variety of detrimental diseases-some with no preventative vaccines or targeted therapies. One such passenger is dengue virus (DENV), which infects up to 400 million people each year and comes in several serotypes (1 to 4) and disease presentations-from mild infection to severe disease and sometimes death. But to treat or prevent dengue requires that we have a more complete picture of the disease pathology. Now, Modhiran et al. and Beatty et al. describe the results of in vitro and in vivo experiments that point to circulating dengue virus non-structural protein 1 (NS1) and the innate immune Toll-like receptor 4 (TLR4) as a focus for basic scientists as well as vaccine and drug developers.. DENV infection protects a patient from future reinfection with the same DENV serotype as well as producing temporary immune protection from severe dengue disease caused by a different ...
Recognition of envelope protein by dengue virus serotype-specific huma by Peter G. Livingston, Ichiro Kurane et al."Recognition of envelope protein by dengue virus serotype-specific huma" by Peter G. Livingston, Ichiro Kurane et al.
We analyzed dengue virus-specific CD4+ CD8- cytotoxic T lymphocytes (CTL) at the clonal level to further understand their role in dengue virus infections. Stimulation of peripheral blood mononuclear cells from two dengue virus type 4 (D4V)-immune donors with live D4V or noninfectious D4V antigen generated 17 HLA class II-restricted CD4+ CTL capable of specific lysis of dengue virus antigen-treated autologous lymphoblastoid cell lines. Thirteen clones were D4V specific, three clones were cross-reactive for D2V and D4V, and one clone was cross-reactive for D1V, D3V, and D4V. Antigen recognition by six D4V-specific clones and three D2V- and D4V-cross-reactive clones was restricted by HLA-DR7. Five D4V-specific CD4+ CTL clones lysed autologous lymphoblastoid cell lines infected with a dengue virus-vaccinia virus recombinant containing the E gene of D4V, whereas three serotype-cross-reactive CTL clones did not. These results indicate that E-specific clones are serotype specific and HLA-DR7 restricted in
Prolonged persistence of IgM against dengue virus detected by commonly used commercial assays<...Prolonged persistence of IgM against dengue virus detected by commonly used commercial assays<...
TY - JOUR. T1 - Prolonged persistence of IgM against dengue virus detected by commonly used commercial assays. AU - Chien, Yu-Wen. AU - Liu, Zi Hu. AU - Tseng, Fan Chen. AU - Ho, Tzu Chuan. AU - Guo, How-Ran. AU - Ko, Nai-Ying. AU - Ko, Wen-Chien. AU - Perng, Guey-Chuen. PY - 2018/4/2. Y1 - 2018/4/2. N2 - Background: Initial symptoms of dengue fever are non-specific, and thus definite diagnosis requires laboratory confirmation. Detection of IgM against dengue virus (DENV) has become widely used for dengue diagnosis. Understanding the persistence of anti-DENV IgM in subjects after acute infection is essential in order to interpret test results correctly. Although the longevity of anti-DENV IgM has been vehemently investigated in symptomatic children, anti-DENV IgM persistence in adults and in asymptomatically infected people have seldom been reported. Methods: We prospectively investigated 44 adults with detectable anti-DENV IgM in a serosurvey conducted in the 2015 dengue epidemic in Tainan, ...
Dengue Viral Myositis Complicated with Rhabdomyolysis and Superinfection of Methicillin-Resistant Staphylococcus aureusDengue Viral Myositis Complicated with Rhabdomyolysis and Superinfection of Methicillin-Resistant Staphylococcus aureus
Dengue is endemic in Sri Lanka and the physician should be aware of different and unusual presentation of the illness. Rhabdomyolysis is a well-known complication following many viral and bacterial infections; however, only a few cases have been reported with dengue viral infections. Further occurrence of coinfection by dengue and bacteria such as methicillin-resistant |i|Staphylococcus aureus|/i| (MRSA) has been underestimated, and few reports have been published so far. This case describes a 17-year-old boy who presented with prolonged severe myalgia, dark red urine, and a febrile illness that was diagnosed as having dengue viral myositis, dark red urine, and a febrile illness that was diagnosed as having dengue viral myositis complicated with rhabdomyolysis and superinfection of MRSA. Despite intensive care management, he died due to multiorgan failure. Autopsy and serological studies confirmed the diagnosis. This case stresses that red-coloured urine in dengue patients is not always due to
Dengue fever - Simple English Wikipedia, the free encyclopediaDengue fever - Simple English Wikipedia, the free encyclopedia
Dengue fever is probably a very old disease. An ancient Chinese medical encyclopedia from the Jin Dynasty (which existed from 265 to 420 AD) talked about a person who probably had dengue. The book talked about a "water poison" that had to do with flying insects.[31][32] Written records from the 17th century talk about what may have been epidemics of dengue (where the disease spread very quickly in a short time). The most likely early reports of dengue epidemics are from 1779 and 1780. These reports talk about an epidemic that spread across Asia, Africa, and North America.[32] From that time until 1940, there were not many more epidemics.[32] In 1906, scientists proved that people were getting infections from Aedes mosquitoes. In 1907, scientists showed that a virus causes dengue. This was just the second disease that was shown to be caused by a virus. (The first was yellow fever.)[33] John Burton Cleland and Joseph Franklin Siler kept studying the dengue virus, and figured out the basics of how ...
Evolutionary dynamics of dengue virus populations within the mosquito vector • Research - Institut PasteurEvolutionary dynamics of dengue virus populations within the mosquito vector • Research - Institut Pasteur
Link to Pubmed [PMID] - 27526393. Curr Opin Virol 2016 Aug;21:47-53. To date, dengue virus evolution has mainly been addressed by studies conducted at the between-host level. Like other pathogens with high mutation rate and rapid replication, dengue viruses also evolve during the course of an infection. Over the last few years, the advent of deep-sequencing technologies has facilitated studies of dengue virus populations at the within-host level. Here, we review recent advances on the evolutionary dynamics of dengue virus populations within their mosquito vector. We discuss how identifying the evolutionary forces acting on dengue virus populations within the mosquito can shed light on the processes underlying vector-virus interactions and the evolution of epidemiologically relevant traits.. http://www.ncbi.nlm.nih.gov/pubmed/27526393 ...
A Word a Day Keeps a Dim Mind at Bay: Dengue shock syndromeA Word a Day Keeps a Dim Mind at Bay: Dengue shock syndrome
Dengue shock syndrome: A syndrome due to the dengue virus that tends to affect children under 10, causing abdominal pain, hemorrhage (bleeding) and circulatory collapse (shock). Known also as dengue hemorrhagic fever (DHF), it starts abruptly with high continuous fever and headache plus respiratory and intestinal symptoms with sore throat, cough, nausea, vomiting, and abdominal pain. Shock occurs after 2 to 6 days with sudden collapse, cool clammy extremities, weak thready pulse, and blueness around the mouth (circumoral cyanosis). There is bleeding with easy bruising, blood spots in the skin (petechiae), spitting up blood (hematemesis), blood in the stool (melena), bleeding gums and nosebleeds (epistaxis). Pneumonia and heart inflammation (myocarditis) may be present. The mortality is appreciable ranging from 6 to 30%. Most deaths occur in children. Infants under a year of age are especially at risk of death. It is also called Philippine or Southeast Asian hemorrhagic fever. ...
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Apollo launches platelet donor community for dengue patients | Business Standard NewsApollo launches platelet donor community for dengue patients | Business Standard News
WHO | What is dengue?WHO | What is dengue?
Climate Change Could Boost U.S. Dengue Fever...'Climate Change Could Boost U.S. Dengue Fever...
Pakistan to get insecticide from India to fight dengue | TopNewsPakistan to get insecticide from India to fight dengue | TopNews
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Dengue Expansion in Africa-Not Recognized or Not Happening? - Volume 20, Number 10-October 2014 - Emerging Infectious Diseases...Dengue Expansion in Africa-Not Recognized or Not Happening? - Volume 20, Number 10-October 2014 - Emerging Infectious Diseases...
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FeverInfectionSerotypesAedesMosquitoesSymptomsSerotypeShockVirusesEndemicNeglected TropicalAntibodiesInfectionsRise in dengue casesEpidemicsDiagnosisEpidemicPlateletCasesForm of dengueOutbreak of denguePrevention of dengueEpidemiology of dengueDiseaseDeaths2016VaccinesIllnessDengvaxia
Fever73
Infection17
Serotypes4
Aedes6
  • At the root of the emergence of dengue as a major health problem are changes in human demography and behavior, leading to unchecked populations of and increased exposure to the principal domestic mosquito vector, Aedes aegypti. (pnas.org)
  • The Aedes aegypti mosquito is the main vector that transmits the viruses that cause dengue . (bingj.com)
  • Dengue is spread by several species of mosquito of the Aedes type, principally A. aegypti. (wikipedia.org)
  • Dengue is an arthropod-borne viral disease whose main vector is the mosquito Aedes aegypti . (scielo.sa.cr)
  • Dengue virus is transmitted by bite of mosquito vector known as Aedes aegypti . (org.pk)
  • 2000. 3.Nyamuk Aedes Aegypti maupun Aedes Albopictus merupakan vektor penularan virus dengue dari penderita kepada oranglainnya melalui gigitannya nyamuk Aedes Aegyeti merupakan vektor penting di daerah perkotaan (Viban) sedangkan didaerah pedesaan (rural) kedua nyamuk tersebut berperan dalam penularan.aedes polynesiensis dan beberapa spesies lain merupakan vektor yang kurang berperan. (scribd.com)
Mosquitoes7
  • Here are 5 effective tips on how to keep mosquitoes away, and thus protect yourself and your family from diseases like Dengue, Malaria and Chikungunya. (ndtv.com)
  • Mosquitoes come to be infected with dengue after biting unwell people who have dengue virus in their blood. (healthandmedicines.com)
  • THURSDAY, Jan. 16, 2020 (HealthDay News) -- Mosquitoes that can't be infected by or spread dengue virus have been created by scientists. (nm.org)
  • The researchers genetically engineered the mosquitoes to be resistant to all four types of dengue, a mosquito-borne virus that's a significant global health threat. (nm.org)
  • This is the first time that mosquitoes have been genetically engineered to be resistant to all types of dengue, which could significantly improve control of the disease, the scientists added. (nm.org)
  • The team reported that it may be possible to create wild populations with such genetically modified mosquitoes that would be completely resistant to dengue. (nm.org)
  • The best way to prevent Dengue is to avoid bites by infected mosquitoes - particularly if you live in, or are traveling in, a tropical region. (indiahomehealthcare.com)
Symptoms4
  • Dengue can be diagnosed clinically against predefined lists of signs and symptoms and by detection of dengue-specific antibodies, non-structural 1 antigen or viral RNA by reverse transcriptase-polymerase chain reaction. (tropmedres.ac)
  • Because there are no specific drugs approved for the treatment of dengue disease, care is limited to the management of symptoms. (medicaldialogues.in)
  • The time taken for Dengue to run its course in most people involves an incubation period of 10 -14 days, followed by a week of acute symptoms, and then a few days of recovery. (indiahomehealthcare.com)
  • This will allow your doctor to evaluate the possibility that your symptoms being caused by the dengue virus. (indiahomehealthcare.com)
Serotype1
Shock2
  • What are the clinical features of Dengue shock syndrome? (org.pk)
  • Di setiap Negara penyakit DBD mempunyai manifestasi klinik yangberbeda.Dengue Shock Syndrome (SSD) / Dengue Syok Sindrom (DSS) adalah kasus deman berdarah dengue disertai denganmanifestasi kegagalan sirkulasi/ syok/ renjatan. (scribd.com)
Viruses5
Endemic5
  • Paris, France - August 13th, 2016 - Sanofi and its vaccines global business unit Sanofi Pasteur announced that 500,000 doses of Dengvaxia ® have been received in Paraná to support a large-scale public dengue immunization program initiated today in the State's 30 most highly endemic municipalities. (sanofi.com)
  • The strategic deployment of a safe and effective dengue vaccine offers the best hope of reducing dengue's burden, especially in highly endemic countries like Brazil. (sanofi.com)
  • Introduction of the dengue vaccine first in endemic countries like Brazil has always been Sanofi Pasteur's priority because this is where the vaccine can have the greatest impact on disease burden globally. (sanofi.com)
  • While there is no cure for dengue disease, today's approval is an important step toward helping to reduce the impact of this virus in endemic regions of the United States. (medicaldialogues.in)
  • The safety and effectiveness of the vaccine was determined in three randomized, placebo-controlled studies involving approximately 35,000 individuals in dengue-endemic areas, including Puerto Rico, Latin America and the Asia Pacific region. (medicaldialogues.in)
Neglected Tropical1
Antibodies1
Infections4
Rise in dengue cases1
Epidemics3
Diagnosis4
  • Thus, timely diagnosis and an accurate prognosis of severe dengue in the first few days of illness for clinical triage, treatment management, disease surveillance and research activities are vital and very helpful. (bl.uk)
  • Early and accurate diagnosis is important for guiding appropriate management and for disease surveillance to guide prompt dengue control interventions. (tropmedres.ac)
  • However, major uncertainties exist in dengue diagnosis and this has important implications for all three. (tropmedres.ac)
  • When a person falls ill from Dengue, it's initially difficult to make a precise diagnosis. (indiahomehealthcare.com)
Epidemic1
Platelet1
  • The patient can also be treated with herbal domestic treatments inclusive of papaya leaves, kiwi, Tulsi Leaves and Black Pepper, Fenugreek Leaves and different meals items which have been verified to assist in the growth of platelet count, which get lower during dengue. (healthandmedicines.com)
Cases5
  • While the incidences of many other infectious diseases have declined over the past decade, the number of cases and outbreaks of dengue virus have continued to increase. (laboratoryequipment.com)
  • Doctors are aware now that dengue is in the Mossman and Port Douglas area and they're reporting their suspicious cases to us. (wordpress.com)
  • Although dengue cases are rare in the continental U.S., the disease is regularly found in American Samoa, Puerto Rico, Guam, the U.S. Virgin Islands, as well as Latin America, Southeast Asia and the Pacific islands. (medicaldialogues.in)
  • He said three dengue cases were also reported from Balochistan province. (pakistannewsindex.com)
  • Younger children and people who have never suffered from Dengue before tend to have milder cases than older children and adults. (indiahomehealthcare.com)
Form of dengue1
  • Someone infected with one form of dengue will best come to be proof against that type. (healthandmedicines.com)
Outbreak of dengue1
Prevention of dengue1
  • Islamabad, Sep 21 - Prime Minister Yousuf Raza Gilani has directed Pakistan International Airlines (PIA) to lift insecticides from India for the prevention of dengue. (topnews.in)
Epidemiology of dengue1
  • Virus-specified factors also influence the epidemiology of dengue. (pnas.org)
Disease8
  • Dengue is fast emerging pandemic-prone viral disease in many parts of the world. (bingj.com)
  • Treatment of acute dengue is supportive and includes giving fluid either by mouth or intravenously for mild or moderate disease. (wikipedia.org)
  • For the public immunization program being launched today, we have used our extensive dengue surveillance data to ensure that we are targeting people at highest risk of disease. (sanofi.com)
  • Paraná has a good track record in vaccination coverage in general and successful implementation of this dengue immunization strategy could result in 74% reduction in disease burden in these highly impacted municipalities within 5 years, according to a dengue vaccine impact study published in the Brazilian Journal of Health Economics 1 ," Secretary Neto noted. (sanofi.com)
  • Dengue disease is the most common mosquito-borne viral disease in the world and global incidence has increased in recent decades," said Anna Abram, FDA deputy commissioner for policy, legislation, and international affairs. (medicaldialogues.in)
  • The vaccine was determined to be approximately 76 percent effective in preventing symptomatic, laboratory-confirmed dengue disease in individuals 9 through 16 years of age who previously had laboratory-confirmed dengue disease. (medicaldialogues.in)
  • They may not be immune to different types of dengue and might be at better threat of extreme disease if they contract another type. (healthandmedicines.com)
  • Dengue is a global public health emergency especially since there is no preventative vaccine or antiviral treatment for dengue disease. (gwu.edu)
Deaths1
  • Paraná State, home to 10 million people, has seen a steep 3-fold increase in both dengue incidence and deaths in recent years. (sanofi.com)
20161
  • The safety, efficacy and public health value of the dengue vaccine has been independently endorsed by the World Health Organization (WHO) in position paper on Dengvaxia published on 29th July 2016 2 , which is consistent with the earlier positive recommendation on the dengue vaccine issued by the WHO's Strategic Advisory Group of Experts on Immunization last April. (sanofi.com)
Vaccines1
Illness2
  • We conducted three studies aiming to identify early markers of dengue, especially severe dengue and identify prognostic markers of severe dengue in Vietnamese children with clinically suspected dengue within the first few days of the illness. (bl.uk)
  • This thesis shows the results and also points out predictive models that may be used to prognosticate of severe dengue among patients with clinically suspected dengue who are admitted to hospital within the first few days of the illness. (bl.uk)
Dengvaxia1
Dengue Fever 101: Common Questions Answered - ABC News
Dengue Fever 101: Common Questions Answered - ABC News (abcnews.go.com)
Dengue Fever News, Research
Dengue Fever News, Research (news-medical.net)
Dengue: the risk to developed and developing countries | PNAS
Dengue: the risk to developed and developing countries | PNAS (pnas.org)
FDA Approves First Vaccine for Dengue, With Restrictions
FDA Approves First Vaccine for Dengue, With Restrictions (medscape.com)
Taiwan Grapples with Record Outbreak of Dengue Fever | Voice of America - English
Taiwan Grapples with Record Outbreak of Dengue Fever | Voice of America - English (voanews.com)
Dropbox - 2014 Direct Costs of Dengue Hospitalization.pdf
Dropbox - 2014 Direct Costs of Dengue Hospitalization.pdf (dropbox.com)
Dengue Fever on the Rise in Singapore - WSJ
Dengue Fever on the Rise in Singapore - WSJ (wsj.com)
Dengue virus: German know‑how in Brazil - Federal Foreign Office
Dengue virus: German know‑how in Brazil - Federal Foreign Office (auswaertiges-amt.de)
Novartis Aims to Have Dengue Fever Drugs in Clinical Trials by 2011 - WSJ
Novartis Aims to Have Dengue Fever Drugs in Clinical Trials by 2011 - WSJ (wsj.com)
Dengue Fever Epidemic in Brazil
Dengue Fever Epidemic in Brazil (wtvy.com)
Protein in mosquito saliva can hinder spread of dengue virus | Health News | Zee News
Protein in mosquito saliva can hinder spread of dengue virus | Health News | Zee News (zeenews.india.com)
Are Philippine children's deaths linked to dengue vaccine? | South China Morning Post
Are Philippine children's deaths linked to dengue vaccine? | South China Morning Post (scmp.com)
Brazil tries genetically modified mosquitoes to fight dengue | South China Morning Post
Brazil tries genetically modified mosquitoes to fight dengue | South China Morning Post (scmp.com)
Expression Profile of Genes during Resistance Reversal in a Temephos Selected Strain of the Dengue Vector, Aedes aegypti
Expression Profile of Genes during Resistance Reversal in a Temephos Selected Strain of the Dengue Vector, Aedes aegypti (journals.plos.org)
PLOS Neglected Tropical Diseases: Mapping Protein Interactions between Dengue Virus and Its Human and Insect Hosts
PLOS Neglected Tropical Diseases: Mapping Protein Interactions between Dengue Virus and Its Human and Insect Hosts (journals.plos.org)
Sanofi Pasteur Makes Progress with Dengue Vaccine | BioPharm International
Sanofi Pasteur Makes Progress with Dengue Vaccine | BioPharm International (biopharminternational.com)
Pathogen blocking in Wolbachia-infected Aedes aegypti is not affected by Zika and dengue virus co-infection
Pathogen blocking in Wolbachia-infected Aedes aegypti is not affected by Zika and dengue virus co-infection (journals.plos.org)
டெங்கு - ஏன்? எப்படி? | Dengue Fever Symptoms, Treatment, Causes & Prevention - Chutti Vikatan | சுட்டி விகடன்
டெங்கு - ஏன்? எப்படி? | Dengue Fever Symptoms, Treatment, Causes & Prevention - Chutti Vikatan | சுட்டி விகடன் (vikatan.com)
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Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever
Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever (journals.plos.org)
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டெங்குக் காய்ச்சலும்... பன்றிக் காய்ச்சலும்! - இனி என்ன செய்ய வேண்டும் நாம்? | Awareness of Dengue Fever and Swine Flu - Junior... (vikatan.com)
Epitopes described in Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. - Immune Epitope...
Epitopes described in Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. - Immune Epitope... (iedb.org)
Summary of Notifiable Infectious Diseases and Conditions - United States, 2015 | MMWR
Summary of Notifiable Infectious Diseases and Conditions - United States, 2015 | MMWR (cdc.gov)
Other Mosquito-Borne Diseases | NIOSH | CDC
Other Mosquito-Borne Diseases | NIOSH | CDC (cdc.gov)
Dengue Fever on Apple Music
Dengue Fever on Apple Music (itunes.apple.com)
Dengue - ISC
Dengue - ISC (isclarity.org)
Diseases Spread by Mosquitoes
Diseases Spread by Mosquitoes (webmd.com)
Principles of Epidemiology | Lesson 1 - Section 10
Principles of Epidemiology | Lesson 1 - Section 10 (cdc.gov)
Dengue Fever - how to articles from wikiHow
Dengue Fever - how to articles from wikiHow (wikihow.com)
Fighting dengue - ABC North Qld - Australian Broadcasting Corporation
Fighting dengue - ABC North Qld - Australian Broadcasting Corporation (abc.net.au)
Pandemic! 10 of the Deadliest Diseases | Popular Science
Pandemic! 10 of the Deadliest Diseases | Popular Science (popsci.com)
Health in Philippines - Lonely Planet
Health in Philippines - Lonely Planet (lonelyplanet.com)
Health in Bali - Lonely Planet
Health in Bali - Lonely Planet (lonelyplanet.com)
The Times of India: Latest News India, World & Business News, Cricket & Sports, Bollywood
The Times of India: Latest News India, World & Business News, Cricket & Sports, Bollywood (timesofindia.indiatimes.com)
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Also In Global Health News: Drug-Resistance Gene; Polio In Nigeria; Dengue Vaccine; River Blindness Diagnostic Test | The Henry... (kff.org)
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Skin rash: 68 pictures, causes, and treatments (medicalnewstoday.com)
Feature Stories | University Of Georgia
Feature Stories | University Of Georgia (uga.edu)