AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and Processes
DenervationMuscle DenervationAutonomic DenervationSympathectomyParasympathectomySympathetic Nervous SystemSympathectomy, ChemicalMuscular AtrophyGanglionectomyMusclesPressoreceptorsNeuromuscular JunctionMuscle, SkeletalVagotomyNerve RegenerationBlood PressureCarotid SinusKidneyVagus NerveCranial Nerve DiseasesReceptors, CholinergicNorepinephrineSciatic Nerve3-IodobenzylguanidineOxidopamineAutonomic Nervous System DiseasesParasympathetic Nervous SystemCarotid BodyReflexDiaphragmNeurons, EfferentRats, Inbred StrainsDogsTime FactorsRats, Sprague-DawleyGlossopharyngeal NerveAdrenergic FibersRats, WistarMotor NeuronsHeart RateHindlimbElectric StimulationHydroxydopaminesHeartMuscle ContractionElectromyographyChemoreceptor CellsMotor EndplateMuscle ProteinsBaroreflexNatriuresisEdrophoniumMuscle Fibers, SkeletalMuscle Fibers, Fast-TwitchTyramineShy-Drager SyndromeTrigeminal NerveDiuresisHyperhidrosisSympatholyticsCatsCapsaicinEphedrineRenal ArterySinus of ValsalvaHypoglossal NerveSodium CyanideAutonomic Fibers, PreganglionicAutonomic Fibers, PostganglionicStellate GanglionPrimary DysautonomiasHypertensionNerve DegenerationPure Autonomic FailureAtrophyMyogeninAxonsGanglia, SympatheticCatecholaminesAcetylcholinePeripheral NervesTongueNeurons, AfferentNerve FibersMuscle DevelopmentNeural ConductionBotulinum ToxinsAcetylcholinesteraseTibial NerveSinoatrial NodeIodobenzenesNerve CrushNerve EndingsCatheter AblationAfferent PathwaysNervous System Physiological PhenomenaTetrodotoxinNictitating MembraneAutonomic Nervous SystemMuscle Fibers, Slow-TwitchGanglia, ParasympatheticMuscular Disorders, AtrophicParalysisBungarotoxinsMasticatory MusclesGanglia, AutonomicGuanethidinePropranololParkinson DiseaseNeuromuscular DiseasesHemodynamicsOphthalmic NerveDisease Models, AnimalSciatic NeuropathyAtropineEfferent PathwaysDiabetic NeuropathiesMandibular NerveIrisReceptors, AdrenergicFacial NerveReserpineRespirationAnimals, NewbornSympathomimeticsArteriesStriatonigral DegenerationAction PotentialsEpinephrineRenal CirculationSchwann CellsPhenylephrineCalcitonin Gene-Related PeptideSpinal Nerve RootsValsalva ManeuverTyrosine 3-MonooxygenaseHexamethonium CompoundsDopamineChorda Tympani NervePhenolPeroneal NerveMyosin Heavy ChainsPrenalterolCorpus StriatumVascular ResistanceRNA, MessengerDihydroergotaminePhentolamineSweat GlandsCholinesterasesSodiumPeripheral Nerve InjuriesParotid Gland
Denervation: The resection or removal of the nerve to an organ or part. (Dorland, 28th ed)Muscle Denervation: The resection or removal of the innervation of a muscle or muscle tissue.Autonomic Denervation: The removal or interruption of some part of the autonomic nervous system for therapeutic or research purposes.Sympathectomy: The removal or interruption of some part of the sympathetic nervous system for therapeutic or research purposes.Parasympathectomy: The removal or interruption of some part of the parasympathetic nervous system for therapeutic or research purposes.Sympathetic Nervous System: The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.Sympathectomy, Chemical: Sympathectomy using chemicals (e.g., 6-hydroxydopamine or guanethidine) which selectively and reversibly destroy adrenergic nerve endings while leaving cholinergic nerve endings intact.Muscular Atrophy: Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.Ganglionectomy: Removal of an autonomic or sensory ganglion by any means.Muscles: Contractile tissue that produces movement in animals.Pressoreceptors: Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.Neuromuscular Junction: The synapse between a neuron and a muscle.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Vagotomy: The interruption or removal of any part of the vagus (10th cranial) nerve. Vagotomy may be performed for research or for therapeutic purposes.Nerve Regeneration: Renewal or physiological repair of damaged nerve tissue.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Carotid Sinus: The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Vagus Nerve: The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).Cranial Nerve Diseases: Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.Receptors, Cholinergic: Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Sciatic Nerve: A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.3-Iodobenzylguanidine: A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.Autonomic Nervous System Diseases: Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.Parasympathetic Nervous System: The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system.Carotid Body: A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.Reflex: An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.Diaphragm: The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.Neurons, Efferent: Neurons which send impulses peripherally to activate muscles or secretory cells.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Glossopharyngeal Nerve: The 9th cranial nerve. The glossopharyngeal nerve is a mixed motor and sensory nerve; it conveys somatic and autonomic efferents as well as general, special, and visceral afferents. Among the connections are motor fibers to the stylopharyngeus muscle, parasympathetic fibers to the parotid glands, general and taste afferents from the posterior third of the tongue, the nasopharynx, and the palate, and afferents from baroreceptors and CHEMORECEPTOR CELLS of the carotid sinus.Adrenergic Fibers: Nerve fibers liberating catecholamines at a synapse after an impulse.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Motor Neurons: Neurons which activate MUSCLE CELLS.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Hindlimb: Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)Electric Stimulation: Use of electric potential or currents to elicit biological responses.Hydroxydopamines: Dopamines with a hydroxy group substituted in one or more positions.Heart: The hollow, muscular organ that maintains the circulation of the blood.Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Electromyography: Recording of the changes in electric potential of muscle by means of surface or needle electrodes.Chemoreceptor Cells: Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.Motor Endplate: The specialized postsynaptic region of a muscle cell. The motor endplate is immediately across the synaptic cleft from the presynaptic axon terminal. Among its anatomical specializations are junctional folds which harbor a high density of cholinergic receptors.Muscle Proteins: The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.Baroreflex: A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.Natriuresis: Sodium excretion by URINATION.Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.Muscle Fibers, Skeletal: Large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of SKELETAL MUSCLE. They consist of MYOFIBRILS enclosed within and attached to the SARCOLEMMA. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation.Muscle Fibers, Fast-Twitch: Skeletal muscle fibers characterized by their expression of the Type II MYOSIN HEAVY CHAIN isoforms which have high ATPase activity and effect several other functional properties - shortening velocity, power output, rate of tension redevelopment. Several fast types have been identified.Tyramine: An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.Shy-Drager Syndrome: A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)Trigeminal Nerve: The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.Diuresis: An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Hyperhidrosis: Excessive sweating. In the localized type, the most frequent sites are the palms, soles, axillae, inguinal folds, and the perineal area. Its chief cause is thought to be emotional. Generalized hyperhidrosis may be induced by a hot, humid environment, by fever, or by vigorous exercise.Sympatholytics: Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Capsaicin: An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.Ephedrine: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.Renal Artery: A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.Sinus of Valsalva: The dilatation of the aortic wall behind each of the cusps of the aortic valve.Hypoglossal Nerve: The 12th cranial nerve. The hypoglossal nerve originates in the hypoglossal nucleus of the medulla and supplies motor innervation to all of the muscles of the tongue except the palatoglossus (which is supplied by the vagus). This nerve also contains proprioceptive afferents from the tongue muscles.Sodium Cyanide: A highly poisonous compound that is an inhibitor of many metabolic processes and is used as a test reagent for the function of chemoreceptors. It is also used in many industrial processes.Autonomic Fibers, Preganglionic: NERVE FIBERS which project from the central nervous system to AUTONOMIC GANGLIA. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the SPINAL CORD, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in SYNAPSES or continue through the SPLANCHNIC NERVES to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the BRAIN STEM and sacral spinal cord. In both divisions the principal transmitter is ACETYLCHOLINE but peptide cotransmitters may also be released.Autonomic Fibers, Postganglionic: Nerve fibers which project from cell bodies of AUTONOMIC GANGLIA to SYNAPSES on target organs.Stellate Ganglion: A paravertebral sympathetic ganglion formed by the fusion of the inferior cervical and first thoracic ganglia.Primary Dysautonomias: Disorders of the AUTONOMIC NERVOUS SYSTEM occurring as a primary condition. Manifestations can involve any or all body systems but commonly affect the BLOOD PRESSURE and HEART RATE.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.Pure Autonomic Failure: A degenerative disease of the AUTONOMIC NERVOUS SYSTEM that is characterized by idiopathic ORTHOSTATIC HYPOTENSION and a greatly reduced level of CATECHOLAMINES. No other neurological deficits are present.Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.Myogenin: A myogenic regulatory factor that controls myogenesis. Myogenin is induced during differentiation of every skeletal muscle cell line that has been investigated, in contrast to the other myogenic regulatory factors that only appear in certain cell types.Axons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Ganglia, Sympathetic: Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.Catecholamines: A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Peripheral Nerves: The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.Tongue: A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.Neurons, Afferent: Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.Nerve Fibers: Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.Muscle Development: Developmental events leading to the formation of adult muscular system, which includes differentiation of the various types of muscle cell precursors, migration of myoblasts, activation of myogenesis and development of muscle anchorage.Neural Conduction: The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.Botulinum Toxins: Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.Acetylcholinesterase: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.Tibial Nerve: The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot.Sinoatrial Node: The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).IodobenzenesNerve Crush: Treatment of muscles and nerves under pressure as a result of crush injuries.Nerve Endings: Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.Catheter Ablation: Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.Afferent Pathways: Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.Nervous System Physiological Phenomena: Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.Nictitating Membrane: A fold of the mucous membrane of the CONJUNCTIVA in many animals. At rest, it is hidden in the medial canthus. It can extend to cover part or all of the cornea to help clean the CORNEA.Autonomic Nervous System: The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.Muscle Fibers, Slow-Twitch: Skeletal muscle fibers characterized by their expression of the Type I MYOSIN HEAVY CHAIN isoforms which have low ATPase activity and effect several other functional properties - shortening velocity, power output, rate of tension redevelopment.Ganglia, Parasympathetic: Ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen.Muscular Disorders, Atrophic: Disorders characterized by an abnormal reduction in muscle volume due to a decrease in the size or number of muscle fibers. Atrophy may result from diseases intrinsic to muscle tissue (e.g., MUSCULAR DYSTROPHY) or secondary to PERIPHERAL NERVOUS SYSTEM DISEASES that impair innervation to muscle tissue (e.g., MUSCULAR ATROPHY, SPINAL).Paralysis: A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)Bungarotoxins: Neurotoxic proteins from the venom of the banded or Formosan krait (Bungarus multicinctus, an elapid snake). alpha-Bungarotoxin blocks nicotinic acetylcholine receptors and has been used to isolate and study them; beta- and gamma-bungarotoxins act presynaptically causing acetylcholine release and depletion. Both alpha and beta forms have been characterized, the alpha being similar to the large, long or Type II neurotoxins from other elapid venoms.Masticatory Muscles: Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)Ganglia, Autonomic: Clusters of neurons and their processes in the autonomic nervous system. In the autonomic ganglia, the preganglionic fibers from the central nervous system synapse onto the neurons whose axons are the postganglionic fibers innervating target organs. The ganglia also contain intrinsic neurons and supporting cells and preganglionic fibers passing through to other ganglia.Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)Neuromuscular Diseases: A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manifestations include MUSCLE WEAKNESS; FASCICULATION; muscle ATROPHY; SPASM; MYOKYMIA; MUSCLE HYPERTONIA, myalgias, and MUSCLE HYPOTONIA.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Ophthalmic Nerve: A sensory branch of the trigeminal (5th cranial) nerve. The ophthalmic nerve carries general afferents from the superficial division of the face including the eyeball, conjunctiva, upper eyelid, upper nose, nasal mucosa, and scalp.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Sciatic Neuropathy: Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)Atropine: An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.Efferent Pathways: Nerve structures through which impulses are conducted from a nerve center toward a peripheral site. Such impulses are conducted via efferent neurons (NEURONS, EFFERENT), such as MOTOR NEURONS, autonomic neurons, and hypophyseal neurons.Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)Mandibular Nerve: A branch of the trigeminal (5th cranial) nerve. The mandibular nerve carries motor fibers to the muscles of mastication and sensory fibers to the teeth and gingivae, the face in the region of the mandible, and parts of the dura.Iris: The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.Receptors, Adrenergic: Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.Facial Nerve: The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and SALIVARY GLANDS, and convey afferent information for TASTE from the anterior two-thirds of the TONGUE and for TOUCH from the EXTERNAL EAR.Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.Respiration: The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).Animals, Newborn: Refers to animals in the period of time just after birth.Sympathomimetics: Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.Arteries: The vessels carrying blood away from the heart.Striatonigral Degeneration: A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6)Action Potentials: Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Renal Circulation: The circulation of the BLOOD through the vessels of the KIDNEY.Schwann Cells: Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.Calcitonin Gene-Related Peptide: Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.Spinal Nerve Roots: Paired bundles of NERVE FIBERS entering and leaving the SPINAL CORD at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots are efferent, comprising the axons of spinal motor and PREGANGLIONIC AUTONOMIC FIBERS.Valsalva Maneuver: Forced expiratory effort against a closed GLOTTIS.Tyrosine 3-Monooxygenase: An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 1.14.16.2.Hexamethonium Compounds: Compounds containing the hexamethylenebis(trimethylammonium) cation. Members of this group frequently act as antihypertensive agents and selective ganglionic blocking agents.Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Chorda Tympani Nerve: A branch of the facial (7th cranial) nerve which passes through the middle ear and continues through the petrotympanic fissure. The chorda tympani nerve carries taste sensation from the anterior two-thirds of the tongue and conveys parasympathetic efferents to the salivary glands.Phenol: An antiseptic and disinfectant aromatic alcohol.Peroneal Nerve: The lateral of the two terminal branches of the sciatic nerve. The peroneal (or fibular) nerve provides motor and sensory innervation to parts of the leg and foot.Myosin Heavy Chains: The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.Prenalterol: A partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute CARDIAC FAILURE, postmyocardial infarction low-output syndrome, SHOCK, and reducing ORTHOSTATIC HYPOTENSION in the SHY-RAGER SYNDROME.Corpus Striatum: Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.Vascular Resistance: The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Dihydroergotamine: A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.Sweat Glands: Sweat-producing structures that are embedded in the DERMIS. Each gland consists of a single tube, a coiled body, and a superficial duct.CholinesterasesSodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Peripheral Nerve Injuries: Injuries to the PERIPHERAL NERVES.Parotid Gland: The largest of the three pairs of SALIVARY GLANDS. They lie on the sides of the FACE immediately below and in front of the EAR.

Possible role of serotonin in Merkel-like basal cells of the taste buds of the frog, Rana nigromaculata. (1/1756)

Merkel-like basal cells in the taste buds of the frog were examined by fluorescence histochemistry, immunohistochemistry and electron microscopy. There were about 16-20 basal cells arranged in a radial fashion at the base of each taste bud. These cells were strongly immunopositive for serotonin antiserum. They were characterised by the presence of numerous dense-cored granules in the cytoplasm ranging from 80 to 120 nm in diameter, and of microvilli protruding from the cell surface. For 4 mo after sensory denervation by cutting the gustatory nerves, all cell types of the taste bud were well preserved and maintained their fine structure. Even at 4 mo after denervation, the basal cells exhibited a strong immunoreaction with serotonin antiserum. To investigate the function of serotonin in the basal cells in taste bud function, serotonin deficiency was induced by administration of p-chlorophenylalanine (PCPA), an inhibitor of tryptophan hydroxylase, and of p-chloroamphetamine (PCA), a depletor of serotonin. After administration of these agents to normal and denervated frogs for 2 wk, a marked decrease, or complete absence, of immunoreactivity for serotonin was observed in the basal cells. Ultrastructurally, degenerative changes were observed in both types of frog; numerous lysosome-like myelin bodies were found in all cell types of the taste buds. The number of dense-cored granules in the basal cells also was greatly decreased by treatment with these drugs. Serotonin in Merkel-like basal cells appears to have a trophic role in maintenance of the morphological integrity of frog taste bud cells.  (+info)

Expression of Mash1 in basal cells of rat circumvallate taste buds is dependent upon gustatory innervation. (2/1756)

Mash1, a mammalian homologue of the Drosophila achaete-scute proneural gene complex, plays an essential role in differentiation of subsets of peripheral neurons. In this study, using RT-PCR and in situ RT-PCR, we investigated if Mash1 gene expression occurs in rat taste buds. Further, we examined dynamics of Mash1 expression in the process of degeneration and regeneration in denervated rat taste buds. In rat tongue epithelium, Mash1 gene expression is confined to circumvallate, foliate, and fungiform papilla epithelia that include taste buds. In taste buds, Mash1-expressing cells are round cells in the basal compartment. In contrast, the mature taste bud cells do not express the Mash1 gene. Denervation and regeneration experiments show that the expression of Mash1 requires gustatory innervation. We conclude that Mash1 is expressed in cells of the taste bud lineage, and that the expression of Mash1 in rat taste buds is dependent upon gustatory innervation.  (+info)

Effect of central corticotropin-releasing factor on carbon tetrachloride-induced acute liver injury in rats. (3/1756)

Central neuropeptides play important roles in many instances of physiological and pathophysiological regulation mediated through the autonomic nervous system. In regard to the hepatobiliary system, several neuropeptides act in the brain to regulate bile secretion, hepatic blood flow, and hepatic proliferation. Stressors and sympathetic nerve activation are reported to exacerbate experimental liver injury. Some stressors are known to stimulate corticotropin-releasing factor (CRF) synthesis in the central nervous system and induce activation of sympathetic nerves in animal models. The effect of intracisternal CRF on carbon tetrachloride (CCl4)-induced acute liver injury was examined in rats. Intracisternal injection of CRF dose dependently enhanced elevation of the serum alanine aminotransferase (ALT) level induced by CCl4. Elevations of serum aspartate aminotransferase, alkaline phosphatase, and total bilirubin levels by CCl4 were also enhanced by intracisternal CRF injection. Intracisternal injection of CRF also aggravated CCl4-induced hepatic histological changes. Intracisternal CRF injection alone did not modify the serum ALT level. Intravenous administration of CRF did not influence CCl4-induced acute liver injury. The aggravating effect of central CRF on CCl4-induced acute liver injury was abolished by denervation of hepatic plexus with phenol and by denervation of noradrenergic fibers with 6-hydroxydopamine treatment but not by hepatic branch vagotomy or atropine treatment. These results suggest that CRF acts in the brain to exacerbate acute liver injury through the sympathetic-noradrenergic pathways.  (+info)

Nitric oxide mediates sympathetic vasoconstriction at supraspinal, spinal, and synaptic levels. (4/1756)

The purposes of this study were to investigate the level of the sympathetic nervous system in which nitric oxide (NO) mediates regional sympathetic vasoconstriction and to determine whether neural mechanisms are involved in vasoconstriction after NO inhibition. Ganglionic blockade (hexamethonium), alpha1-receptor blockade (prazosin), and spinal section at T1 were used to study sympathetic involvement. NO was blocked with Nomega-nitro-L-arginine methyl ester (L-NAME). Regional blood flow in the mesenteric and renal arteries and terminal aorta was monitored by electromagnetic flowmetry in conscious rats. L-NAME (3-5 mg/kg iv) increased arterial pressure and peripheral resistance. Ganglionic blockade (25 mg/kg iv) significantly reduced the increase in resistance in the mesentery and kidney in intact and spinal-sectioned rats. Ganglionic blockade significantly decreased hindquarter resistance in intact rats but not in spinal-sectioned rats. Prazosin (200 micrograms/kg iv) significantly reduced the increased hindquarter resistance. We concluded that NO suppresses sympathetic vasoconstriction in the mesentery and kidney at the spinal level, whereas hindquarter tone is mediated at supraspinal and synaptic levels.  (+info)

Erythromycin enhances early postoperative contractility of the denervated whole stomach as an esophageal substitute. (5/1756)

OBJECTIVE: To determine whether early postoperative administration of erythromycin accelerates the spontaneous motor recovery process after elevation of the denervated whole stomach up to the neck. SUMMARY BACKGROUND DATA: Spontaneous motor recovery after gastric denervation is a slow process that progressively takes place over years. METHODS: Erythromycin was administered as follows: continuous intravenous (i.v.) perfusion until postoperative day 10 in ten whole stomach (WS) patients at a dose of either 1 g (n = 5) or 2 g (n = 5) per day; oral intake at a dose of 1 g/day during 1.5 to 8 months after surgery in 11 WS patients, followed in 7 of them by discontinuation of the drug during 2 to 4 weeks. Gastric motility was assessed with intraluminal perfused catheters in these 21 patients, in 23 WS patients not receiving erythromycin, and in 11 healthy volunteers. A motility index was established by dividing the sum of the areas under the curves of >9 mmHg contractions by the time of recording. RESULTS: The motility index after IV or oral administration of erythromycin at and after surgery was significantly higher than that without erythromycin (i.v., 1 g: p = 0.0090; i.v., 2 g: p = 0.0090; oral, 1 g: p = 0.0017). It was similar to that in healthy volunteers (i.v., 1 g: p = 0.2818; oral, 1 g: p = 0.7179) and to that in WS patients with >3 years of follow-up who never received erythromycin (i.v., 1 g: p = 0.2206; oral, 1 g: p = 0.8326). The motility index after discontinuation of the drug was similar or superior to that recorded under medication in four patients who did not experience any modification of their alimentary comfort, whereas it dropped dramatically parallel to deterioration of the alimentary comfort in three patients. CONCLUSIONS: Early postoperative contractility of the denervated whole stomach pulled up to the neck under either i.v. or oral erythromycin is similar to that recovered spontaneously beyond 3 years of follow-up. In some patients, this booster effect persists after discontinuation of the drug.  (+info)

Heterogeneous cardiac sympathetic denervation and decreased myocardial nerve growth factor in streptozotocin-induced diabetic rats: implications for cardiac sympathetic dysinnervation complicating diabetes. (6/1756)

Heterogeneous myocardial sympathetic denervation complicating diabetes has been invoked as a factor contributing to sudden unexplained cardiac death. In subjects with diabetic autonomic neuropathy (DAN), distal left ventricular (LV) denervation contrasts with preservation of islands of proximal innervation, which exhibit impaired vascular responsiveness. The aims of this study were to determine whether this heterogeneous pattern of myocardial sympathetic denervation occurs in a rat model of diabetes and to explore a potential association with regional fluctuations in myocardial nerve growth factor (NGF) protein. Myocardial sympathetic denervation was characterized scintigraphically using the sympathetic neurotransmitter analog C-11 hydroxyephedrine ([11C]HED) and compared with regional changes in myocardial NGF protein abundance and norepinephrine content after 6 and 9 months in nondiabetic (ND) and streptozotocin-induced diabetic (STZ-D) rats. In ND rats, no difference in [11C]HED retention or norepinephrine content was detected in the proximal versus distal myocardium. After 6 months, compared with ND rats, myocardial [11C]HED retention had declined in the proximal segments of STZ-D rats by only 9% (NS) compared with a 33% decrease in the distal myocardium (P < 0.05). Myocardial norepinephrine content was similar in both ND and STZ-D rats. At 6 months, LV myocardial NGF protein content in STZ-D rats decreased by 52% in the proximal myocardial segments (P < 0.01 vs. ND rats) and by 82% distally (P < 0.01 vs. ND rats, P < 0.05 vs. proximal segments). By 9 months, [11C]HED retention had declined in both the proximal and distal myocardial segments of the STZ-D rats by 42% (P < 0.01 vs. ND rats), and LV norepinephrine content and NGF protein were decreased in parallel. Therefore, 6 months of STZ-induced diabetes results in heterogeneous cardiac sympathetic denervation in the rat, with maximal denervation occurring distally, and is associated with a proximal-to-distal gradient of LV NGF protein depletion. It is tempting to speculate that regional fluctuations of NGF protein in the diabetic myocardium contribute to heterogeneous cardiac sympathetic denervation complicating diabetes.  (+info)

Hypoxia inhibits baroreflex vagal bradycardia via a central action in anaesthetized rats. (7/1756)

It is known that arterial baroreflexes are suppressed in stressful conditions. The present study was designed to determine whether and how hypoxia affects arterial baroreflexes, especially the heart rate component, baroreflex vagal bradycardia. In chloralose-urethane-anaesthetized rats, baroreflex vagal bradycardia was evoked by electrical stimulation of the aortic depressor nerve, and the effect of 15 s inhalation of hypoxic gas (4% O2) was studied. Inhalation of hypoxic gas was found to inhibit baroreflex vagal bradycardia. The inhibition persisted after bilateral transection of the carotid sinus nerve. Cervical vagus nerves were cut bilaterally and their peripheral cut ends were stimulated to provoke vagal bradycardia of peripheral origin so as to determine whether hypoxia could inhibit vagal bradycardia by acting on a peripheral site. In contrast to baroreflex vagal bradycardia, the vagus-induced bradycardia was not affected by hypoxic gas inhalation. It is concluded that baroreflex vagal bradycardia is inhibited by hypoxia and the inhibition is largely mediated by its direct central action.  (+info)

A substituted dextran enhances muscle fiber survival and regeneration in ischemic and denervated rat EDL muscle. (8/1756)

Ischemia and denervation of EDL muscle of adult rat induce a large central zone of degeneration surrounded by a thin zone of peripheral surviving muscle fibers. Muscle regeneration is a complex phenomenon in which many agents interact, such as growth factors and heparan sulfate components of the extracellular matrix. We have shown that synthetic polymers, called RGTA (as regenerating agents), which imitate the heparan sulfates, are able to stimulate tissue repair when applied at the site of injury. In crushed muscles, RGTA were found to accelerate both regeneration and reinnervation. In vitro, RGTA act as protectors and potentiators of various heparin binding growth factors (HBGF). It was postulated that in vivo their tissue repair properties were due in part to an increase of bioavailability of endogenously released HBGF. In the present work, we show that ischemic and denervated EDL muscle treated by a unique injection of RGTA differs from the control after 1 wk in several aspects: 1) the epimysial postinflammatory reaction is inhibited and the area of fibrotic tissue among fibers is reduced; 2) the peripheral zone, as measured by the number of intact muscle fibers, was increased by more than twofold; and 3) In the central zone, RGTA enhances the regeneration of the muscle fibers as well as muscle revascularization. These results suggest that RGTA both protects muscle fibers from degeneration and preserves the differentiated state of the surviving fibers. For the first time it is demonstrated that a functionalized polymeric compound can prevent some of the damage resulting from muscle ischemia. RGTA may therefore open a new therapeutic approach for muscle fibrosis and other postischemic muscle pathologies.  (+info)

Preliminary results of RETREAT renal denervation study go against the grain - Interventional NewsPreliminary results of RETREAT renal denervation study go against the grain - Interventional News
Renal denervation with ultrasound after performed after prior denervation with radiofrequency seems to be safe. After an initial decrease of blood pressure after one month, we observed an increase in blood pressure in this small number of patients, a finding which has not been seen in other denervation studies," said Sievert.. RETREAT is a physician-initiated prospective, multicentre study with no industry funding in which 30 patients will be enrolled. Its purpose is to evaluate the effect of renal denervation using ultrasound energy (with Recors Paradise system) after failed denervation with radiofrequency (with Medtronics Symplicity system).. Sievert said: "Enrolment in the RETREAT study coincided with the publication of the SYMPLICITY HTN-3 study results following which the reimbursement for renal denervation was stopped in Germany. There was a decline in referrals for renal denervation and new treatment modalities for hypertension began to be explored. This resulted in enrolment becoming ...
Renal Denervation on Quality of 24-hr BP Control by Ultrasound In Resistant Hypertension | Clinical Research Trial Listing (...Renal Denervation on Quality of 24-hr BP Control by Ultrasound In Resistant Hypertension | Clinical Research Trial Listing (...
Clinical trial for Diabetes and Hypertension | High Blood Pressure (Hypertension - Pediatric) | Vascular Diseases | High Blood Pressure (Hypertension) | Cardiovascular Disease | Hypertension , Renal Denervation on Quality of 24-hr BP Control by Ultrasound In Resistant Hypertension
The DENERHTN Randomized Controlled Trial: Renal Denervation for Resistant Hypertension Revisited - HeartThe DENERHTN Randomized Controlled Trial: Renal Denervation for Resistant Hypertension Revisited - Heart
Despite large reductions in blood pressure seen in early studies of renal denervation, the SYMPLICITY HTN-3 randomized trial failed to show a reduction in systolic blood pressure with renal denervation when compared to medical therapy alone. As a result, interest in renal denervation as a treatment for resistant hypertension has waned. In the DENERHTN trial, Azizi and colleagues assessed the incremental benefit of adding renal denervation to standardized stepped-care antihypertensive treatment (SSAHT) for patients with resistant hypertension in an open-label, randomized-controlled trial with blinded endpoint evaluation. After four weeks of a standardized anti-hypertensive regimen to confirm resistant hypertension, patients were randomized to renal denervation in addition to SSAHT versus SSAHT alone. The primary endpoint was the mean change in daytime systolic blood pressure after six months as assessed by ambulatory monitoring. Of the 106 patients randomized (53 in each group), 101 had endpoints ...
Vessix to Present V2 Renal Denervation Systemâ„¢ for Hypertension at LINC 2012Vessix to Present V2 Renal Denervation Systemâ„¢ for Hypertension at LINC 2012
LAGUNA HILLS, Calif., Jan. 18, 2012 /PRNewswire/ -- Vessix Vascular, Inc., a developer of novel percutaneous radiofrequency (RF) balloon catheter technology, announced today that the first public presentation of its new percutaneous V2 Renal Denervation System™ for the treatment of medication-resistant hypertension will be made at LINC 2012 in Leipzig, Germany on Thursday, January 26, 2012. Renal denervation is a new percutaneous catheter-based technique for the treatment of medication resistant or uncontrolled hypertension. The new V2 Renal Denervation System is designed to be faster, easier to deploy and less invasive for the patient than the alternatives available today in the market.. The presentation, titled "Radiofrequency balloon-mediated renal denervation: The V2 Catheter by Vessix Vascular," will be made by Prof. med. Horst Sievert during a session for new emerging technologies for renal denervation chaired by Krishna Rocha-Singh, M.D.. Dr. Sievert, a globally recognized ...
Medtronic announces SPYRAL HTN global clinical trial programme for renal denervation - Interventional NewsMedtronic announces SPYRAL HTN global clinical trial programme for renal denervation - Interventional News
Physicians in both studies will perform renal denervation with Medtronics next-generation renal denervation technology, composed of the highly flexible 6Fr-compatible, multi-electrode Symplicity Spyral catheter and Symplicity G3 radiofrequency generator. The Symplicity Spyral catheter and G3 generator are investigational in the USA and Japan.. "Medtronic believes the underlying science behind renal denervation is strong and that there is a clear unmet need for people with uncontrolled hypertension. Therefore, we remain committed to exploring the clinical potential of renal denervation in this population," said Jason Weidman, vice president and general manager, Medtronic Coronary and Renal Denervation, within Medtronics Coronary and Structural Heart business. "To get to this point, we have performed extensive analyses and conducted additional pre-clinical testing following the SYMPLICITY HTN-3 trial. We have also consulted with the FDA and reimbursement bodies, and partnered with renowned ...
Arterial wall and smooth muscle cell development in young Wistar rats and the effects of surgical denervation. | Circulation...Arterial wall and smooth muscle cell development in young Wistar rats and the effects of surgical denervation. | Circulation...
Development of the muscular saphenous artery and the effect of surgical denervation on normal development was investigated in young rats at 3 and 6 weeks of age. During this interval, the weight and blood pressures (systolic, diastolic, and mean) of the animals increased significantly. The tunica media of the artery and the lumen increased significantly with age, but the proportion of smooth muscle cell to paracellular matrix did not alter. Computer-assisted three-dimensional reconstructions were used to investigate the smooth muscle cells. They increased significantly in length, volume, and angle of orientation within the vessel wall with age but maintained an approximate surface area-to-volume ratio. The cells in any one vessel tended to be oriented in either a clockwise or counterclockwise direction. The size of the nucleus also increased significantly in length and volume with age, but an approximate surface area-to-volume ratio and a constant nucleocytoplasmic ratio were maintained. The ...
Dynamic Analysis of Renal Nerve Activity Responses to Baroreceptor Denervation in Hypertensive Rats | HypertensionDynamic Analysis of Renal Nerve Activity Responses to Baroreceptor Denervation in Hypertensive Rats | Hypertension
Interruption of afferent input from the sinoaortic and cardiac baroreceptors resulted in a decrease in the correlation dimension and the greatest Lyapunov exponent of the nonlinear dynamic characteristics of synchronized RSNA that was different among Sprague-Dawley rats, WKY, and SHR. In Sprague-Dawley rats, the immediate responses to sinoaortic and cardiac baroreceptor denervation were qualitatively similar to those seen in previous studies7 in which 60 minutes was allowed to elapse between the completion of the denervation procedure and the collection of the experimental data. However, there are important quantitative differences in that the decrease in the correlation dimension was less in the present study (immediate, 2.42 versus 2.16, −11%) than in the previous study (60 minutes, 2.65 versus 1.64, −38%), while the situation was opposite for the greatest Lyapunov exponent (immediate, 0.199 versus 0.130, −35%; 60 minutes, 0.201 versus 0.177, −12%). With respect to central nervous ...
SYMPLICITY HTN-3 Renal Denervation in Patients With Uncontrolled Hypertension - Full Text View - ClinicalTrials.govSYMPLICITY HTN-3 Renal Denervation in Patients With Uncontrolled Hypertension - Full Text View - ClinicalTrials.gov
The Symplicity HTN-3 study is a, multi-center, prospective, single-blind, randomized, controlled study of the safety and effectiveness of renal denervation in subjects with uncontrolled hypertension. Bilateral renal denervation will be performed using the Symplicity Catheter - a percutaneous system that delivers radiofrequency (RF)energy through the luminal surface of the renal artery ...
Renal Denervation in Diabetic Nephropathy - Full Text View - ClinicalTrials.govRenal Denervation in Diabetic Nephropathy - Full Text View - ClinicalTrials.gov
The DERENEDIAB study is a proof-of-concept, multi-center, prospective, open, randomized, controlled study of the effectiveness of renal denervation in addition to standardized medical treatment compared to medical treatment alone in diabetic subjects with diabetic nephropathy and resistant proteinuria. Bilateral renal denervation will be performed using the Symplicity Catheter - a percutaneous system that delivers radiofrequency (RF) energy through the luminal surface of the renal artery ...
Third-generation renal denervation technology presented at CRT15 - ReDy - Third-Generation Renal DenervationThird-generation renal denervation technology presented at CRT15 - ReDy - Third-Generation Renal Denervation
About hypertension. Hypertension is a chronic medical condition in which blood pressure in the arteries is elevated. Blood pressure is expressed by two measurements, systolic and diastolic pressures, which are the maximum and minimum pressures, respectively, in the arterial system. Normal blood pressure at rest is within the range of 100-140 mmHg systolic and 60-90 mmHg diastolic. Hypertension is present if the blood pressure is persistently at or above 140/90 mmHg for adults. Sustained hypertension over time is a major risk factor for heart disease, coronary artery disease, stroke, aortic aneurysm, peripheral artery disease and chronic kidney disease. Hypertension affects over 1 billion people worldwide.. About renal denervation. Renal denervation is an interventional approach for the treatment of high blood pressure. A minimally-invasive, endovascular-catheter-based procedure, it uses radiofrequency or ultrasound ablation to treat resistant hypertension. Nerves in the wall of the renal artery ...
op.7d.10] the Effect of Renal Denervation on Adipokines in Patients with Resistant Hypertension. - Semantic Scholarop.7d.10] the Effect of Renal Denervation on Adipokines in Patients with Resistant Hypertension. - Semantic Scholar
OBJECTIVE We have previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. Obesity also contributes to hypertension. A number of adipocyte-derived factors (collectively termed adipokines) have been implicated in BP control. The aim of this study was to examine the effect of RDN on adipokines. In particular, whether BP reduction, associated with RDN treatment, has a favourable outcome on adipokine profile in patients with resistant hypertension (RH). DESIGN AND METHOD Fifty seven patients with RH undergoing RDN have been recruited for the study (65% males, age 60.8 ± 1.5 years, BMI 32.6 ± 0.7 kg/m, mean ± SEM). At recruitment the patients were on an average of 4.8 ± 2.1 antihypertensive drugs and were asked to refrain from changing their medication regimen for the duration of the study. Automated seated office BP measurements were taken with an Omron HEM-705 monitor at baseline
Covidien to Exit OneShot Renal Denervation ProgramCovidien to Exit OneShot Renal Denervation Program
Covidien [1] plc has announced it will exit its OneShot Renal Denervation program. This voluntary action is primarily in response to slower than expected development of the renal denervation market.. The OneShot system is an over-the-wire balloon-based irrigated catheter technology for the treatment of hypertension. The system received CE Mark in February 2012 and is not approved for sale in the United States.. This decision resulted from Covidiens regular review of strategic programs and growth potential for various aspects of its product portfolio.. As a result of this decision the company will not proceed with its RAPID II randomized study. Additionally, Covidien expects to record after-tax charges in the range of $20 to $25 million as a result of exiting the OneShot program.. Over the next several weeks, the company will collaborate with physicians and the renal denervation community to ensure existing OneShot patients are informed and the currently enrolling clinical trials are ...
Steady-State and Dynamic Responses of Renal Sympathetic Nerve Activity to Air-Jet Stress in Sinoaortic Denervated Rats |...Steady-State and Dynamic Responses of Renal Sympathetic Nerve Activity to Air-Jet Stress in Sinoaortic Denervated Rats |...
The results of the present study support the conclusion that in rats, the arterial baroreceptor reflex largely mediates the stress-induced increases in Mayer waves and associated RSNA oscillations. In rats with chronic SAD, stress enhances fluctuations of MAP and RSNA in the frequency band containing Mayer waves but does not unmask any predominant rhythmicity at Mayer waves frequency.. In baroreceptor-intact and SAD rats, a continuous jet of air blown into the cage increased RSNA and MAP, which is characteristic of the defense reaction in rats.26,27 In SAD rats, although the stress-induced increase in RSNA was similar to that observed in control rats, the increase in MAP was larger. The latter finding accords with a previous report.22 These differential effects of stress on MAP were not related to cardiac factors because the autonomic innervation of the heart had been blocked. Stress did not markedly alter the gain of the transfer function between RSNA and MAP in SAD rats, which suggests that ...
Vessix receives the CE mark for V2 Renal Denervation System for treatment of hypertension | Cardiovascular NewsVessix receives the CE mark for V2 Renal Denervation System for treatment of hypertension | Cardiovascular News
The CE mark enables Vessix to market its patented V2 System throughout the European Union. The CE certification was issued to Vessix by its notified body, BSI Group, also known as the British Standards Institution.. "Vessix offers a unique approach to treating uncontrolled hypertension that provides excellent clinical results and is faster, easier to use and less painful for patients than any renal denervation system currently available in the market," said CEO Raymond W Cohen. "After eight years optimising radiofrequency balloon catheter and bipolar radiofrequency generator technologies, it is rewarding to see the V2 System working effectively in clinical practice to safely reduce patient blood pressures. As part of our commercialisation strategy, Vessix has initiated a post-market approval surveillance study during which we plan to treat 120 patients at up to 20 international centers located across Western Europe.". Renal denervation has shown in published clinical studies to be safe, durable ...
Renal Denervation in CKD Hypertensive Patients: Would it be Possible to Prevent the Development of Risk Factors Responsible for...Renal Denervation in CKD Hypertensive Patients: Would it be Possible to Prevent the Development of Risk Factors Responsible for...
Renal Denervation in CKD Hypertensive Patients: Would it be Possible to Prevent the Development of Risk Factors Responsible for Sudden Cardiac Death in this Population?
Renal denervation effective for uncontrolled hypertension in patients not taking medications | News for Doctor, Nurse,...Renal denervation effective for uncontrolled hypertension in patients not taking medications | News for Doctor, Nurse,...
Renal denervation effective for uncontrolled hypertension in patients not taking medications in European Society of Cardiology (ESC) Congress 2017 | MIMS Malaysia
News for Medical Independent Sales Representatives and Medical Distributors: Renal Denervation Technology from St. Jude Medical...News for Medical Independent Sales Representatives and Medical Distributors: Renal Denervation Technology from St. Jude Medical...
Healthcare Sales & Marketing Network: Renal Denervation Technology from St. Jude Medical Demonstrates Safe, Rapid and Sustained Reduction in Blood Pressure
Site Map | Renal Denervation (RDN World)Site Map | Renal Denervation (RDN World)
This site is meant for educational purposes only no medical advice is given or implied. Renal denervation is still an experimental treatment in many parts of the world, including the United States.. If you are already registered,please enter your email here.. ...
Any hope for renal denervation after SYMPLICITY HTN-3? - Mayo ClinicAny hope for renal denervation after SYMPLICITY HTN-3? - Mayo Clinic
Peter A. Brady, M.B., Ch.B., M.D., and Rajiv Gulati, M.D., Ph.D., discuss renal denervation following the SYMPLICITY HTN-3 trial.
Rapid Atrial Pacing in Cardiac Denervated Dogs Causes Sodium Retention and Not Natriuresis | Clinical Science | Portland PressRapid Atrial Pacing in Cardiac Denervated Dogs Causes Sodium Retention and Not Natriuresis | Clinical Science | Portland Press
T D M Williams, K P Walsh, M I M Noble, A J Drake-Holland, E Pitts, S L Lightman, R Sutton; Rapid Atrial Pacing in Cardiac Denervated Dogs Causes Sodium Retention and Not Natriuresis. Clin Sci (Lond) 1 January 1988; 75 (s19): 31P. doi: https://doi.org/10.1042/cs075031P. Download citation file:. ...
Contact Us | Renal Denervation (RDN World)Contact Us | Renal Denervation (RDN World)
Contact Us RDNworld welcomes your questions and comments about this website. Please send any questions to the managing editor. Nima Shah Phone:718-701
What is Disc Denervation? | Renova SpineWhat is Disc Denervation? | Renova Spine
Disc denervation is used to treat chronic disc-related or discogenic pain using radiofrequency ablation to destroy affected nerves causing pain.
Patente US20050261672 - Systems and methods for selective denervation of heart dysrhythmias - Google PatentesPatente US20050261672 - Systems and methods for selective denervation of heart dysrhythmias - Google Patentes
Methods and apparatus are provided for selective denervation of conduction pathways in the heart for the treatment of dysrhythmias, including one or more ablation or electroporation catheters having electrodes for stimulating, targeting, and ablating fat pad tissue and other cardiac tissue to selectively denervate heart tissue.
AboutBFS.com • View topic - Back from neuro, 10% scared, 30% unhappy.AboutBFS.com • View topic - Back from neuro, 10% scared, 30% unhappy.
I can understand your worry, i have every symptom i read on this board in just a short time of 5 months. Maybe my story will ease your mind or make you want to sort out better medical advice..so far i have been seen by 3 different neurologist, a team of neurologist whilst in hosptial for my symptoms and i have had every blood test most drs will order, a mri of spine which showed abnormalities, a mri of the brain which showed abnormalities, and a emg which showed chronic denervation in all my muslces tested, yet my neurologists rule out ALS even with my emg findings because of my clinical exam being fine each time they check me. Twithcing is definitely not something they will diagnose ALS off from my experience, you have to have some clear weakness and a very conclusive als type dirty emg reading before they will go near a diagnoses. So keep your spirits high and be happy that it was twitches you woke up with and not weakness or paralized limbs or severe bulbar issues because that to my ...
US Patent Application for FEEDBACK SYSTEMS AND METHODS FOR RENAL DENERVATION UTILIZING BALLOON CATHETER Patent Application ...US Patent Application for FEEDBACK SYSTEMS AND METHODS FOR RENAL DENERVATION UTILIZING BALLOON CATHETER Patent Application ...
A renal denervation system includes an ablation catheter and an inflation balloon. The renal denervation catheter is insertable into a renal artery to perform a renal denervation procedure. The inflation balloon is inflatable within the renal artery, wherein one of a blood pressure condition in the renal artery resulting from operation of the inflation balloon and a performance characteristic of the inflation balloon indicates efficacy of the renal denervation procedure.
Addressing key questions on renal denervation with the SPYRAL HTN global clinical trial programmeAddressing key questions on renal denervation with the SPYRAL HTN global clinical trial programme
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Inhibition of glycolysis in the denervated dog heart. | Circulation ResearchInhibition of glycolysis in the denervated dog heart. | Circulation Research
We measured glucose metabolism in five dogs before and 3 weeks after cardiac denervation; after this time myocardial norepinephrine is depleted. The discharge by the myocardium, of 14CO2 from infused 14C-D-glucose (U), decreased following denervation (P = 0.05). The ratio of 14CO2 to total CO2 production, which measured the proportion of glucose to total substrate oxidized, also decreased following denervation (P = 0.05). The inhibition of glucose oxidation by denervation was not due to an increase in arterial lactate concentration. There was an associated increase in myocardial content of fructose-6-phosphate in an additional seven dogs (P , 0.01). We postulate that myocardial tissue norepinephrine is one of the controllers of the activity of phosphofructokinase. ...
Carotid Body Denervation Prevents the Development of Insulin Resistance and Hypertension Induced by Hypercaloric Diets |...Carotid Body Denervation Prevents the Development of Insulin Resistance and Hypertension Induced by Hypercaloric Diets |...
Increased sympathetic activity is a well-known pathophysiological mechanism in insulin resistance (IR) and hypertension (HT). The carotid bodies (CB) are peripheral chemoreceptors that classically respond to hypoxia by increasing chemosensory activity in the carotid sinus nerve (CSN), causing hyperventilation and activation of the sympathoadrenal system. Besides its role in the control of ventilation, the CB has been proposed as a glucose sensor implicated in the control of energy homeostasis. However, to date no studies have anticipated its role in the development of IR. Herein, we propose that CB overstimulation is involved in the etiology of IR and HT, core metabolic and hemodynamic disturbances of highly prevalent diseases like the metabolic syndrome, type 2 diabetes, and obstructive sleep apnoea. We demonstrate that CB activity is increased in IR animal models and that CSN resection prevents CB overactivation and diet-induced IR and HT. Moreover, we show that insulin triggers CB, ...
GW24-e1415 NE, Renin, Ang-II, ALD, ET-1, which one is the best indicator for renal denervation of treatment of resistant...GW24-e1415 NE, Renin, Ang-II, ALD, ET-1, which one is the best indicator for renal denervation of treatment of resistant...
Results Systolic blood pressure after catheter-based renal denervation decreased by 35.52 ± 17.65, 36.63 ± 18.54 mmHgat 6 months and 1 year, respectively (P , 0.001). Diastolic blood pressure decreased by 15.19 ± 15.44, 16.13 ± 15.51 mmHg, at 6 months, and 1 year, respectively (P , 0.001). Meanwhile, there is a clear positive correlation between NE and the BP reduction (r2 = 0.82, P , 0.001), and a similar correlation between rennin (r2 = 0.72, P , 0.001), AngII (r2 = 0.75, P , 0.001), ALD (r2 = 0.71, P , 0.001), ET-1 (r2 = 0.72, P , 0.001) and the BP reduction was observed in our study. In addition, there is a significantly decline in NE, renin, AngII, ALD and ET-1 (all P , 0.01).. ...
Expression of Caveolin-1 in Penile Cavernosal Tissue in a Denervated Animal Model after Treatment with Sildenafil CitrateExpression of Caveolin-1 in Penile Cavernosal Tissue in a Denervated Animal Model after Treatment with Sildenafil Citrate
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
Trust Pharmacy: Red viagra c200 express shipping!Trust Pharmacy: Red viagra c200 express shipping!
Cavitation-induced erosion is especially great between the flared iliac of the migraine attack, symptoms of children the dures of a drug acts on d1 and d7 receptors and their derivatives show tremendous potential in regenera- of pluripotential cells from immune rejection by others, renal denervation on 21-h ambulatory bp monitoring [24], awake and asleep is compatible with malignancy (including mass size >3 5 cm, no ideal cut off has been losing weight rapidly and produces effec- the activity of drugs that affect hepatic enzyme deficiency. The transplantation technology using releasing various chemicals, including thromboxane, chinese hamster ovary cell and ilar to or posterior major line rotates to same side result in and the amino acid derivative acetylcysteine. However, in some the ivc (see upper vagina chapter 5 pelvis and the antidysrhythmic agents dysrhythmia terminates after adenosine administration, then it is important to watch a movie and eat ice cream. Table 1.1 presents the initial ...
DiVA - SøkeresultatDiVA - Søkeresultat
It has been suggested that skeletal nerves fibers may play important roles in neuro-osteogenic interactions. This view is partly based upon information obtained from immunohistochemical studies, chemical and surgical denervation experiments and clinical observations in patients with stroke and spinal cord injury, indicating the presence of a network of nerve fibers in the skeleton and that defective signalling in skeletal nerve fibers affects remodelling of bone. This view is also supported by data showing that functional receptors for signalling molecules in skeletal nerve fibers are expressed in bone cells and that activation of these receptors leads to profound effects on bone forming osteoblasts and bone resorbing osteoclasts. Convincing evidence for a role of neuronal signalling in bone metabolism has been provided by gene deletion approaches in which it has been shown that leptin-sensitive and neuropeptide Y-sensitive receptors in hypothalamus are important for bone remodelling in mice. ...
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The increase in total integrated voltage of renal sympathetic nerve activity that occurs with peripheral thermal receptor stimulation (heat) decreases renal blood flow, and the renal vasoconstriction is prevented by prior renal denervation (34). As it was this stimulus that identified a unique subset of single renal sympathetic nerve fibers, we sought to determine quantitative aspects of the renal sympathetic neural discharge seen in multifiber recordings that were produced by peripheral thermal receptor stimulation. Postganglionic multifiber renal sympathetic nerve activity occurs in synchronized sympathetic discharges (bursts, peaks) with distinct coupling to the cardiac cycle. These synchronized renal sympathetic peaks may be characterized by their amplitude, duration, and frequency. Total integrated voltage encompasses the product of voltage under the curve of each peak (governed largely by peak amplitude as peak duration changes little) and peak frequency. Therefore, changes in total ...
Facet Denervation Charlottesville VA | Pain ManagementFacet Denervation Charlottesville VA | Pain Management
Facet Denervation is available in Charlottesville VA. Facet Joints are the joints between the vertebrae in your spine that allow flexibility in the back.
AboutBFS.com • View topic - In hospital, really scared...AboutBFS.com • View topic - In hospital, really scared...
my hotspot is my foot as well, well both feet really. They are twitching ALL THE TIME. Sorry to hear about your voice scare, its reassuring though that its gone back to normal. I have some bulbar concerns myself, as my tongue has lately been extremely sore, like I burned it on soup. This has made me very aware of my speech, Im feeling like Im stumbling over words, biting the tip of my tongue, and every now and then my voice breaks when I talk. Ive been told that this might be psychosomatic, from all that fear and worry im experiencing. I hope so , who knows... Im actually starting therapy next week (something I never thought I would do), but I think it will be good to not load this stuff on my family and friends so much anymore. I still worry about those EMG results and chronic denervation, even though docs told me they would see spontaneous activity if it were a motor neurone problem... But increasing symptoms just make me doubtful. Im sure you can relate, considering yours have been ...
Sinoaortic contribution to ventilatory control in exercising dogs.Sinoaortic contribution to ventilatory control in exercising dogs.
The role of the sinoaortic reflexes in the regulation of ventilation during exercise was evaluated in seven awake dogs prepared with chronic tracheostomies and arterial catheters. Each dog ran on a treadmill at several work loads before and after sin
Study: Botox Could Prevent Spread of Gastric Cancer | Cancer NetworkStudy: Botox Could Prevent Spread of Gastric Cancer | Cancer Network
In a preliminary study using a mouse model, researchers found that vagal denervation using Botox or other methods could help slow gastric cancers growth.
Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy | Acta Neuropathologica...Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy | Acta Neuropathologica...
Based on reports that S1P-receptor signaling is involved in neuronal plasticity (e.g., [34, 40, 41]), regulation of neurite remodeling (e.g., [40, 42]), and neuroprotection (e.g., [33, 43, 44]) and also because of the relevance of FTY720 in the treatment of MS, we wondered whether FTY720 could have an influence on denervation-induced dendritic changes. Indeed, FTY720 prevented the denervation-induced reduction in TDL. Furthermore, dynamic imaging revealed that FTY720 stabilizes denervated dendrites and thus prevents the denervation-induced change in the balance of dendritic retraction and elongation. This "neuro-stabilization" seems to be a direct effect of FTY720 on neural tissue, since the peripheral immune system, which is regarded as the main target of FTY720, is missing in organotypic slice culture preparations. To control for off-target effects of FTY720 (and its agonist-antagonist properties; [16-18]), we repeated these experiments with the S1PR1/3-inhibitor VPC23019 and obtained very ...
Terumo Granted CE Mark for Renal Sympathetic Denervation SystemTerumo Granted CE Mark for Renal Sympathetic Denervation System
Tokyo ― Terumo Corporation (TSE: 4543 Section 1) announced CE marking for the commercial sale of the Iberis™ Renal Sympathetic Denervation System, which the company has consigned product development to Shanghai AngioCare Medical Technology Co., Ltd. (hereinafter AngioCare) (Representative: Philip Wang), a Chinese company in renal sympathetic denervation technology for resistant hypertension treatment.. In December, 2012, Terumo formed a strategic alliance with AngioCare. Furthermore, the company has consigned product development to AngioCare and acquired the exclusive distribution rights for its renal sympathetic denervation technology on the global market.. Sales of Iberis in Europe will be commenced with its launch at the worlds leading cardiovascular intervention course, EuroPCR to be held in France in May, 2013.. Terumo aims to expand its renal sympathetic denervation business by launching Iberis in Asian and Latin American countries where the CE marked product is allowed for ...
NESPS - Growth Hormone Ameliorates the Effects of Chronic Denervation Injury on Peripheral Nerve Regeneration and Improves...NESPS - Growth Hormone Ameliorates the Effects of Chronic Denervation Injury on Peripheral Nerve Regeneration and Improves...
2016 Annual Meeting: Growth Hormone Ameliorates the Effects of Chronic Denervation Injury on Peripheral Nerve Regeneration and Improves Upper Extremity Murine Function
Frontiers | Renal Denervation Promotes Atherosclerosis in Hypertensive Apolipoprotein E-Deficient Mice Infused with Angiotensin...Frontiers | Renal Denervation Promotes Atherosclerosis in Hypertensive Apolipoprotein E-Deficient Mice Infused with Angiotensin...
Objective: To determine the effect of renal denervation (RDN) on the severity of atherosclerosis and aortic aneurysm in hypertensive mice. Methods: Hypertension, atherosclerosis and aortic aneurysm were induced by subcutaneous infusion of angiotensin II (1 µg/kg/min) for 28 days in apolipoprotein E-deficient mice. RDN was conducted using combined surgical and local chemical denervation. The norepinephrine concentration in the kidney was measured by high-performance liquid chromatography. Blood pressure was measured by the tail-cuff method. Atherosclerosis was assessed by Sudan IV staining of the aortic arch. The aortic diameter was measured by the morphometric method. The mRNA expression of genes associated with atherosclerosis and aortic aneurysm were analyzed by quantitative PCR. Results: RDN decreased the median norepinephrine content in the kidney by 93.4% (n=5-7, P=0.003) five days after the procedure, indicating that the RDN procedure was successful. RDN decreased systolic blood pressure in
Specialist Cardiology | Renal DenervationSpecialist Cardiology | Renal Denervation
Renal sympathetic denervation (RSDN), or renal denervation (RDN), is a minimally invasive, endovascular catheter based procedure using radiofrequency ablation or ultrasound ablation aimed at treating resistant hypertension (high blood pressure not controlled by medication).
The localization and rate of disappearance of a synaptic vesicle antigen following denervation. :: MPG.PuReThe localization and rate of disappearance of a synaptic vesicle antigen following denervation. :: MPG.PuRe
Author: Borroni, E. et al.; Genre: Journal Article; Published in Print: 1985-08; Title: The localization and rate of disappearance of a synaptic vesicle antigen following denervation.
Treatment of facet syndrome with radiofrequency denervation: Costs for treatment #260607 in Germany | BookingHealthTreatment of facet syndrome with radiofrequency denervation: Costs for treatment #260607 in Germany | BookingHealth
Treatment of facet syndrome with radiofrequency denervation (costs for program #260607) ✔ Asklepios Academic City Hospital Bad Wildungen ✔ Department of Neurosurgery and Spine Surgery ✔ BookingHealth.com
Treatment of facet syndrome with radiofrequency denervation: Costs for treatment #183895 in Germany | BookingHealthTreatment of facet syndrome with radiofrequency denervation: Costs for treatment #183895 in Germany | BookingHealth
Treatment of facet syndrome with radiofrequency denervation (costs for program #183895) ✔ St. Anna Hospital Herne ✔ Department of Orthopedics and Trauma Surgery ✔ BookingHealth.com
Krames Online - Understanding Radiofrequency DenervationKrames Online - Understanding Radiofrequency Denervation
Radiofrequency denervation is a treatment for some kinds of lower back and neck pain. It uses an electrical current created by radio waves.
106 of the best peer-reviewed specialists in radiofrequency denervation |TopDoctors106 of the best peer-reviewed specialists in radiofrequency denervation |TopDoctors
Find and book the best doctor specialised in radiofrequency denervation. Compare patient reviews, insurance, prices and get your referral letter instantly.
Surgical cardiac denervation therapy for treatment of congenital ion c by John P. Costello, Jennifer K. Wilson et al."Surgical cardiac denervation therapy for treatment of congenital ion c" by John P. Costello, Jennifer K. Wilson et al.
Costello, J.P., Wilson, J.K., Louis, C., Peer, S.M., Zurakowski, D. et al. (2015). Surgical cardiac denervation therapy for treatment of congenital ion channelopathies in pediatric patients: a contemporary, single institutional experience. World Journal of Pediatric and Congenital Heart Surgery, 6(1), 33-38.. ...
Christian Daugaard Peters - Research outputs - Research - Aarhus UniversityChristian Daugaard Peters - Research outputs - Research - Aarhus University
The effect of renal denervation on arterial stiffness, central blood pressure and heart rate variability in treatment resistant essential hypertension: a substudy of a randomized sham-controlled double-blinded trial (the ReSET trial). / Peters, Christian Daugaard; Mathiassen, Ole Norling; Vase, Henrik; Bech Nørgaard, Jesper; Christensen, Kent Lodberg; Schroeder, Anne Pauline; Rickers, Hans Joachim von Hofe; Opstrup, Ulla Kampmann; Poulsen, Per Løgstrup; Langfeldt, Sten; Andersen, Gratien; Hansen, Klavs Würgler; Bøtker, Hans Erik; Engholm, Morten; Bertelsen, Jannik Buus; Pedersen, Erling Bjerregaard; Kaltoft, Anne; Buus, Niels Henrik.. In: Blood Pressure, Vol. 26, No. 6, 2017, p. 366-380 .. Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review ...
Renal denervation in heart failure: Modulating the sympathetic nervous systemRenal denervation in heart failure: Modulating the sympathetic nervous system
This journal subscribes to the principles and guidelines of the Committee on Publication Ethics (COPE)www.publicationethics.org ...
Renal Artery Intervention (including renal denervation) - ONARenal Artery Intervention (including renal denervation) - ONA
We offer clinical cancer updates, treatment guidance, and research news to the oncology nursing community. Visit us often for drug therapy testing results, patient care information and more. Download our FREE app today.
Terms of Use - ReDy - Third-Generation Renal DenervationTerms of Use - ReDy - Third-Generation Renal Denervation
This Site is owned and operated by ReDy and all copyright rights in text, images, graphics and other content are owned by ReDy, unless otherwise noted. Any rights not expressly granted herein are reserved. Reproduction, transfer, distribution or storage of part or all of the contents in any form without the prior written permission of ReDy is prohibited except in accordance with the following terms. ReDy consents to you browsing this Site on your computer or printing copies of extracts from these pages for your personal use only and not for commercial redistribution unless consented to in writing by ReDy . Individual documents on our Site may be subject to additional terms indicated in those documents. The use of this Site and the content therein is permitted to private, noncommercial use provided all copyright and other proprietary notices are adhered to. The use of press releases and other documents classified as public is permitted in public communications if the source of the information has ...
EuroIntervention: Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy.CBSET | CBSETEuroIntervention: Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy.CBSET | CBSET
Rothman A, Jonas M, Castel D, Tzafriri AR, Traxler H, Shav D, Leon MB, Ben-Yehuda O, Rubin L. Pulmonary Artery Denervation Using Catheter based Ultrasonic
Please ask questions before Denervation - Surgical Therapies - Post Vasectomy Pain ForumPlease ask questions before Denervation - Surgical Therapies - Post Vasectomy Pain Forum
I would ask any potential person to ask many questions before having spermatic cord denervation. Especially regarding stats that make this look like a better treatment then is stated. Almost everyone will likely feel b…
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Following kainate lesions of hippocampal subfield CA3, the remaining CA 1 pyramidal cells become hyperexcitable. This lesion is of interest because, morphologically, it resembles the damage often seen in cases of temporal lobe epilepsy; it may provide insight into the consequences of such cell loss in humans. The hyperexcitability in CA 1 is associated with a loss of both early and late IPSPs. At long postlesion latencies (2-4 months) inhibition shows partial recovery and the hyperexcitability subsides. The intent of the present work was to determine if alterations in CA 1 excitability and functional inhibition postlesion are correlated with changes in morphologic and physiologic indicators of inhibitory interneuron function or with alterations in binding sites for inhibitory transmitters. Using GAD immunocytochemistry, we found no acute or chronic lesion-induced decrease in numbers of CA 1 interneurons or in qualitative characteristics of the pericellular distribution of their terminals in CA 1 ...
Vincristine Local Delivery for Renal Artery Denervation | Springer for Research & DevelopmentVincristine Local Delivery for Renal Artery Denervation | Springer for Research & Development
The contribution of renal sympathetic nerve activity to the development and progression of resistant hypertension, has been convincingly demonstrated in both preclinical and human experiments....
TCT: Renal Nerve Ablation Drops BP, Heart Rate | Medpage TodayTCT: Renal Nerve Ablation Drops BP, Heart Rate | Medpage Today
MIAMI -- Renal denervation aimed at reducing refractory blood pressure provides some patients with an additional benefit -- a reduction in heart rate.
PCR State-of-the-art lecture on The resurgence of renal denervation | EurekAlert! Science NewsPCR State-of-the-art lecture on 'The resurgence of renal denervation' | EurekAlert! Science News
Renal denervation (RDN) represents a device-based hypertension treatment intended to lower sympathetic activity. Only a few years ago, RDN was written off as ineffective after results of the sham-controlled SYMPLICITY HTN-3 trial failed to confirm early trials reports of significant BP reductions in patients resistant to guideline- based combination drug therapy.
Ciliary ganglionCiliary ganglion
Ross syndromeRoss' syndrome
Salomon Z. LangerSalomon Z. Langer
Neural top-down control of physiologyNeural top-down control of physiology
ChronaxieChronaxie
Substance PSubstance P
Catecholaminergic polymorphic ventricular tachycardiaCatecholaminergic polymorphic ventricular tachycardia
Brachial plexus injuryBrachial plexus injury
ReinnervationReinnervation
ApraclonidineApraclonidine
Endoscopic thoracic sympathectomyEndoscopic thoracic sympathectomy
Loin pain hematuria syndromeLoin pain hematuria syndrome
Trypanosoma cruziTrypanosoma cruzi
Teres minor muscleTeres minor muscle
Diabetic cardiomyopathyDiabetic cardiomyopathy
RabaptinRabaptin
Quadrilateral space syndromeQuadrilateral space syndrome
SNARE (protein)SNARE (protein)
Lateral pectoral nerveLateral pectoral nerve
Familial amyloid neuropathyFamilial amyloid neuropathy
Occipital neuralgiaOccipital neuralgia
Postural orthostatic tachycardia syndromePostural orthostatic tachycardia syndrome
Paroxysmal sympathetic hyperactivityParoxysmal sympathetic hyperactivity
Aging movement controlAging movement control
Wrinkle testWrinkle test
Regeneration (biology)Regeneration (biology)
Disuse supersensitivityDisuse supersensitivity
František VyskočilFrantišek Vyskočil
Spasmodic dysphoniaSpasmodic dysphonia
Radiofrequency ablationRadiofrequency ablation
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and Processes
DenervationMuscle DenervationAutonomic DenervationSympathectomyParasympathectomySympathetic Nervous SystemSympathectomy, ChemicalMuscular AtrophyGanglionectomyMusclesPressoreceptorsNeuromuscular JunctionMuscle, SkeletalVagotomyNerve RegenerationBlood PressureCarotid SinusKidneyVagus NerveCranial Nerve DiseasesReceptors, CholinergicNorepinephrineSciatic Nerve3-IodobenzylguanidineOxidopamineAutonomic Nervous System DiseasesParasympathetic Nervous SystemCarotid BodyReflexDiaphragmNeurons, EfferentRats, Inbred StrainsDogsTime FactorsRats, Sprague-DawleyGlossopharyngeal NerveAdrenergic FibersRats, WistarMotor NeuronsHeart RateHindlimbElectric StimulationHydroxydopaminesHeartMuscle ContractionElectromyographyChemoreceptor CellsMotor EndplateMuscle ProteinsBaroreflexNatriuresisEdrophoniumMuscle Fibers, SkeletalMuscle Fibers, Fast-TwitchTyramineShy-Drager SyndromeTrigeminal NerveDiuresisHyperhidrosisSympatholyticsCatsCapsaicinEphedrineRenal ArterySinus of ValsalvaHypoglossal NerveSodium CyanideAutonomic Fibers, PreganglionicAutonomic Fibers, PostganglionicStellate GanglionPrimary DysautonomiasHypertensionNerve DegenerationPure Autonomic FailureAtrophyMyogeninAxonsGanglia, SympatheticCatecholaminesAcetylcholinePeripheral NervesTongueNeurons, AfferentNerve FibersMuscle DevelopmentNeural ConductionBotulinum ToxinsAcetylcholinesteraseTibial NerveSinoatrial NodeIodobenzenesNerve CrushNerve EndingsCatheter AblationAfferent PathwaysNervous System Physiological PhenomenaTetrodotoxinNictitating MembraneAutonomic Nervous SystemMuscle Fibers, Slow-TwitchGanglia, ParasympatheticMuscular Disorders, AtrophicParalysisBungarotoxinsMasticatory MusclesGanglia, AutonomicGuanethidinePropranololParkinson DiseaseNeuromuscular DiseasesHemodynamicsOphthalmic NerveDisease Models, AnimalSciatic NeuropathyAtropineEfferent PathwaysDiabetic NeuropathiesMandibular NerveIrisReceptors, AdrenergicFacial NerveReserpineRespirationAnimals, NewbornSympathomimeticsArteriesStriatonigral DegenerationAction PotentialsEpinephrineRenal CirculationSchwann CellsPhenylephrineCalcitonin Gene-Related PeptideSpinal Nerve RootsValsalva ManeuverTyrosine 3-MonooxygenaseHexamethonium CompoundsDopamineChorda Tympani NervePhenolPeroneal NerveMyosin Heavy ChainsPrenalterolCorpus StriatumVascular ResistanceRNA, MessengerDihydroergotaminePhentolamineSweat GlandsCholinesterasesSodiumPeripheral Nerve InjuriesParotid Gland
Renal Denervation in Diabetic Nephropathy - Full Text View - ClinicalTrials.govRenal Denervation in Diabetic Nephropathy - Full Text View - ClinicalTrials.gov
Covidien to Exit OneShot Renal Denervation ProgramCovidien to Exit OneShot Renal Denervation Program
Patente US20050261672 - Systems and methods for selective denervation of heart dysrhythmias - Google PatentesPatente US20050261672 - Systems and methods for selective denervation of heart dysrhythmias - Google Patentes
The DENERHTN Randomized Controlled Trial: Renal Denervation for Resistant Hypertension Revisited - HeartThe DENERHTN Randomized Controlled Trial: Renal Denervation for Resistant Hypertension Revisited - Heart
Arterial wall and smooth muscle cell development in young Wistar rats and the effects of surgical denervation. | Circulation...Arterial wall and smooth muscle cell development in young Wistar rats and the effects of surgical denervation. | Circulation...
News for Medical Independent Sales Representatives and Medical Distributors: Renal Denervation Technology from St. Jude Medical...News for Medical Independent Sales Representatives and Medical Distributors: Renal Denervation Technology from St. Jude Medical...
Any hope for renal denervation after SYMPLICITY HTN-3? - Mayo ClinicAny hope for renal denervation after SYMPLICITY HTN-3? - Mayo Clinic
Site Map | Renal Denervation (RDN World)Site Map | Renal Denervation (RDN World)
Contact Us | Renal Denervation (RDN World)Contact Us | Renal Denervation (RDN World)
What is Disc Denervation? | Renova SpineWhat is Disc Denervation? | Renova Spine
Renal denervation effective for uncontrolled hypertension in patients not taking medications | News for Doctor, Nurse,...Renal denervation effective for uncontrolled hypertension in patients not taking medications | News for Doctor, Nurse,...
Renal Denervation in CKD Hypertensive Patients: Would it be Possible to Prevent the Development of Risk Factors Responsible for...Renal Denervation in CKD Hypertensive Patients: Would it be Possible to Prevent the Development of Risk Factors Responsible for...
Denervation - WikipediaDenervation - Wikipedia
Denervation supersensitivity - WikipediaDenervation supersensitivity - Wikipedia
Renal (Kidney) Denervation for Uncontrolled Hypertension | HuffPostRenal (Kidney) Denervation for Uncontrolled Hypertension | HuffPost
Denervation Surgery for Painful JointsDenervation Surgery for Painful Joints
SPYRAL HTN-OFF MED: Reopens Renal-Denervation ConversationSPYRAL HTN-OFF MED: Reopens Renal-Denervation Conversation
Renal Denervation: Blood Pressure Benefit in New Meta-analysisRenal Denervation: Blood Pressure Benefit in New Meta-analysis
Denervation symptoms, treatments & forums | PatientsLikeMeDenervation symptoms, treatments & forums | PatientsLikeMe
Ytube cord denervation | Modern...'Y'tube cord denervation | Modern...
Translational medicine: the antihypertensive effect of renal denervation. - PubMed - NCBITranslational medicine: the antihypertensive effect of renal denervation. - PubMed - NCBI
Renal denervation reduces recurrent AF after ablation | EurekAlert! Science NewsRenal denervation reduces recurrent AF after ablation | EurekAlert! Science News
Renal Denervation Flops in Pivotal Trial | Medpage TodayRenal Denervation Flops in Pivotal Trial | Medpage Today
TCT: Renal Denervation No Better Than Sham | MedPage TodayTCT: Renal Denervation No Better Than Sham | MedPage Today
Covidien Introduces OneShot Renal Denervation SystemCovidien Introduces OneShot Renal Denervation System
Local Sympathetic Denervation in Painful Diabetic Neuropathy | DiabetesLocal Sympathetic Denervation in Painful Diabetic Neuropathy | Diabetes
Bilateral Renal Artery Stenosis After Renal Denervation | HypertensionBilateral Renal Artery Stenosis After Renal Denervation | Hypertension
Catheter-Based Renal Denervation for Resistant Hypertension | HypertensionCatheter-Based Renal Denervation for Resistant Hypertension | Hypertension
Renal Denervation Market Size Is Expected To Reach $ 3,153Renal Denervation Market Size Is Expected To Reach $ 3,153
Otsuka Finds Paradise in Renal Denervation Market | MDDI OnlineOtsuka Finds Paradise in Renal Denervation Market | MDDI Online
Denervation suppresses gastric tumorigenesis | Science Translational MedicineDenervation suppresses gastric tumorigenesis | Science Translational Medicine
Spironolactone versus renal nerve denervation for treatment... : Journal of HypertensionSpironolactone versus renal nerve denervation for treatment... : Journal of Hypertension
Vessix V2 Renal Denervation System Receives CE Mark ApprovalVessix V2 Renal Denervation System Receives CE Mark Approval
Hope for renal denervation revived with new sham-controlled trialsHope for renal denervation revived with new sham-controlled trials
Radiofrequency denervation for chronic low back pain | CochraneRadiofrequency denervation for chronic low back pain | Cochrane
Cardiac sympathetic denervation for conventional treatment refractory arrhythmias.Cardiac sympathetic denervation for conventional treatment refractory arrhythmias.
PCR State-of-the-art lecture on The resurgence of renal denervation | EurekAlert! Science NewsPCR State-of-the-art lecture on 'The resurgence of renal denervation' | EurekAlert! Science News
Multi-electrode Radiofrequency Renal Denervation System Feasibility Study - Full Text View - ClinicalTrials.govMulti-electrode Radiofrequency Renal Denervation System Feasibility Study - Full Text View - ClinicalTrials.gov
Cognitive correlates of cortical cholinergic denervation in Parkinsons disease and parkinsonian dementia | SpringerLinkCognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia | SpringerLink
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and Processes
DenervationMuscle DenervationAutonomic DenervationSympathectomyParasympathectomySympathetic Nervous SystemSympathectomy, ChemicalMuscular AtrophyGanglionectomyMusclesPressoreceptorsNeuromuscular JunctionMuscle, SkeletalVagotomyNerve RegenerationBlood PressureCarotid SinusKidneyVagus NerveCranial Nerve DiseasesReceptors, CholinergicNorepinephrineSciatic Nerve3-IodobenzylguanidineOxidopamineAutonomic Nervous System DiseasesParasympathetic Nervous SystemCarotid BodyReflexDiaphragmNeurons, EfferentRats, Inbred StrainsDogsTime FactorsRats, Sprague-DawleyGlossopharyngeal NerveAdrenergic FibersRats, WistarMotor NeuronsHeart RateHindlimbElectric StimulationHydroxydopaminesHeartMuscle ContractionElectromyographyChemoreceptor CellsMotor EndplateMuscle ProteinsBaroreflexNatriuresisEdrophoniumMuscle Fibers, SkeletalMuscle Fibers, Fast-TwitchTyramineShy-Drager SyndromeTrigeminal NerveDiuresisHyperhidrosisSympatholyticsCatsCapsaicinEphedrineRenal ArterySinus of ValsalvaHypoglossal NerveSodium CyanideAutonomic Fibers, PreganglionicAutonomic Fibers, PostganglionicStellate GanglionPrimary DysautonomiasHypertensionNerve DegenerationPure Autonomic FailureAtrophyMyogeninAxonsGanglia, SympatheticCatecholaminesAcetylcholinePeripheral NervesTongueNeurons, AfferentNerve FibersMuscle DevelopmentNeural ConductionBotulinum ToxinsAcetylcholinesteraseTibial NerveSinoatrial NodeIodobenzenesNerve CrushNerve EndingsCatheter AblationAfferent PathwaysNervous System Physiological PhenomenaTetrodotoxinNictitating MembraneAutonomic Nervous SystemMuscle Fibers, Slow-TwitchGanglia, ParasympatheticMuscular Disorders, AtrophicParalysisBungarotoxinsMasticatory MusclesGanglia, AutonomicGuanethidinePropranololParkinson DiseaseNeuromuscular DiseasesHemodynamicsOphthalmic NerveDisease Models, AnimalSciatic NeuropathyAtropineEfferent PathwaysDiabetic NeuropathiesMandibular NerveIrisReceptors, AdrenergicFacial NerveReserpineRespirationAnimals, NewbornSympathomimeticsArteriesStriatonigral DegenerationAction PotentialsEpinephrineRenal CirculationSchwann CellsPhenylephrineCalcitonin Gene-Related PeptideSpinal Nerve RootsValsalva ManeuverTyrosine 3-MonooxygenaseHexamethonium CompoundsDopamineChorda Tympani NervePhenolPeroneal NerveMyosin Heavy ChainsPrenalterolCorpus StriatumVascular ResistanceRNA, MessengerDihydroergotaminePhentolamineSweat GlandsCholinesterasesSodiumPeripheral Nerve InjuriesParotid Gland
HypertensionProcedureRadiofrequencySymplicityEfficacySystemPhysiciansMedicalDevelopmentTechnologyHypertensionEffects of Renal DenervationProcedureEffect of renalMuscle denervationSystolicResistantRadiofrequencyClinicalShown that renal denervationRationale for renal denervationUltrasound-based renal denervationAblationMulti-electrodeSymplicity SpyralAtrophyTreatmentGlobal renal denervationEnlightnMedtronic's2018Catheter is introducedTherapyOneShotSuggested that renalCardiac denervationSurgical denervationCholinergic denervationChanges in the renalNerves
Hypertension4
Procedure2
Radiofrequency1
Symplicity3
Efficacy1
System1
Physicians1
  • Over the next several weeks, the company will collaborate with physicians and the renal denervation community to ensure existing OneShot patients are informed and the currently enrolling clinical trials are transitioned appropriately. (mdtmag.com)
Medical1
Development1
Technology1
Hypertension85
Effects of Renal Denervation1
Procedure21
Effect of renal3
Muscle denervation6
  • Following an acute polio infection diagnosis symptoms such as fatiguability , general weakness and pain are believed to be correlated to muscle denervation. (wikipedia.org)
  • In regard to skeletal muscle denervation there are two distinct diagnoses: entrapment and compressive neuropathies or non-entrapment neuropathies. (wikipedia.org)
  • In neonatal muscles, however, terminal Schwann cells quickly die by apoptosis after muscle denervation ( Trachtenberg and Thompson, 1996 ). (jneurosci.org)
  • 2 Muscle denervation is a major clinical feature of MND and results in fluid shifts detectable as altered T2 signal characteristics 3 that, in contrast to clinical assessments, are independent of participant's effort and premorbid abilities. (bmj.com)
  • Following muscle denervation, normally quiescent terminal Schwann cells (SCs) become 'reactive' a phenotype characterized by the growth of SC processes, SC proliferation, SC migration from synapses and the induction of nerve terminal sprouting. (utexas.edu)
  • My results show that Nrg signaling in SCs can account for many of the morphological changes observed in terminal SCs following muscle denervation. (utexas.edu)
Systolic8
Resistant2
Radiofrequency15
Clinical12
  • So we can't become too excited about these data referable to clinical application, but what we can do is accept the fact that these data initiate the conversations again about renal denervation. (medscape.com)
  • Steffen Desch, MD, of the University of Leipzig Heart Center, who reported the findings at a late-breaking clinical trial session at the Transcatheter Cardiovascular Therapeutics meeting here, told MedPage Today that renal sympathetic denervation "may have an application in science, but not in the clinic except for the very rare patient. (medpagetoday.com)
  • Over the next several weeks, the company will collaborate with physicians and the renal denervation community to ensure existing OneShot patients are informed and the currently enrolling clinical trials are transitioned appropriately. (mdtmag.com)
  • The patented RF balloon catheter connects to a proprietary bipolar RF generator specifically designed and optimized for the renal denervation clinical application. (medgadget.com)
  • There were no major adverse events at 6 months in the overall study population, but more specifically, in the renal denervation cohort, there were no major clinical events, including no new renal artery stenosis or worsening renal function and no major bleeding or vascular complications, Kandzari reported. (healio.com)
  • Renal nerve denervation (RND) entered clinical trials backed by strong preclinical evidence alongside decades of clinical research confirming the strong contribution of the adrenergic system to the hypertensive continuum. (springer.com)
  • We look forward to moving forward with our clinical evaluation of this next-generation system that aims to augment our portfolio by offering more sophisticated features that should benefit both physicians and patients,' Medtronic's president of coronary & renal denervation Sean Salmon said in prepared remarks. (mdtmag.com)
  • Accordingly, there is no doubt that renal denervation is not ready for clinical use. (springer.com)
  • Medtronic is also the closest to winning FDA approval for renal denervation, with U.S. clinical trials approved in the summer of 2011 . (massdevice.com)
  • Here we propose a minimally invasive Laparoscopic Denervation System (LDS) to serve this unmet clinical need. (embs.org)
  • Although impulsive choices are exacerbated in PD patients with ICDs under DRTs, some clinical and preclinical studies suggest that the DA denervation of the dorsal striatum induced by the neurodegenerative process as well as a pre-existing high impulsivity trait, may both contribute to the emergence of ICDs in PD. (frontiersin.org)
  • The demonstration of cholinergic denervation with an anatomy that fits the clinical picture suggests that cholinergic treatment is justified in patients with PPA who have positive AD biomarkers. (neurology.org)
Shown that renal denervation1
  • Initial studies have shown that renal denervation is able to reduce not only blood pressure but also heart rate, and is associated with a reduction in myocardial hypertrophy, improved glucose tolerance, and ameliorated microalbuminuria. (ovid.com)
Rationale for renal denervation1
Ultrasound-based renal denervation2
Ablation4
  • ReCor Medical was created in 2009 by Sofinnova Partners and has developed the Paradise System, an ultrasound ablation system for renal denervation. (mddionline.com)
  • Methods and apparatus are provided for selective denervation of conduction pathways in the heart for the treatment of dysrhythmias, including one or more ablation or electroporation catheters having electrodes for stimulating, targeting, and ablating fat pad tissue and other cardiac tissue to selectively. (google.es)
  • Little is known about the extent of vagal denervation and recovery of parasympathetic function after ablation.This study examined electrophysiological changes in parasympathetic response to the atria after surgical ablation. (ahajournals.org)
  • The CE-marked EnligHTN renal denervation system, which features a non-occlusive basket design, includes a guiding catheter, ablation catheter and ablation generator. (medicaldevice-network.com)
Multi-electrode1
Symplicity Spyral1
  • The prospective, international, randomized, sham-controlled study is investigating the blood pressure-lowering effect and safety of renal denervation with the Symplicity Spyral system in the absence of medication. (evtoday.com)
Atrophy7
  • This magnified image of type 2 muscle fibers shows denervation atrophy occurring at the white spaces at the top left and bottom center of the image. (wikipedia.org)
  • The motor unit areas soon increase to a point where reinnervation is no longer possible causing an uncompensated denervation of motor units which leads to muscle atrophy and loss of muscular strength. (wikipedia.org)
  • Following denervation, muscular atrophy and degeneration occurs within affected skeletal muscle tissue. (wikipedia.org)
  • Denervation of rat soleus muscle and simultaneous administration of high doses of corticosteroids for 7 days caused marked muscle fiber atrophy and selective loss of thick myofilaments from many muscle fibers by light and electron microscopy. (nih.gov)
  • Because blocking myostatin in an adult wild-type mouse induces profound muscle hypertrophy, we applied a soluble ActRIIB receptor to models of disuse (limb immobilization) and denervation (sciatic nerve resection) atrophy. (biologists.org)
  • Denervation atrophy, however, was not protected by ActRIIB treatment, yet resulted in an upregulation of the pro-growth factors Akt, SGK and components of the mTOR pathway. (biologists.org)
  • Thus, our studies show that denervation atrophy is not only independent from Akt, SGK and mTOR activation but also has a different underlying pathophysiological mechanism than disuse atrophy. (biologists.org)
Treatment19
Global renal denervation4
  • global renal denervation market size is expected to reach USD 1.03 billion by 2026, according to a new report by the Grand View Research, Inc. The market is estimated to register a CAGR of 43.2% during the forecast period. (medindia.net)
  • Publisher's analysts forecast the global renal denervation market to grow at a CAGR of 11.82% during the period 2016-2020. (emailwire.com)
  • The report covers the present scenario and the growth prospects of the global renal denervation market for 2016-2020. (emailwire.com)
  • Publisher's report, Global Renal Denervation Market 2016-2020, has been prepared based on an in-depth market analysis with inputs from industry experts. (emailwire.com)
Enlightn3
Medtronic's2
  • This feasibility study represents Medtronic's commitment to providing physicians with a broader range of solutions for performing renal denervation and to collaborating with physician partners in the ongoing evaluation of this ground-breaking therapy. (mdtmag.com)
  • Along with the Global Symplicity Registry, conducted outside the United States, Medtronic's renal denervation program includes more than 4,000 patients, studied in the presence and absence of medication, and in patients with high baseline cardiovascular risk. (globenewswire.com)
20183
Catheter is introduced2
Therapy4
OneShot2
Suggested that renal1
Cardiac denervation1
  • Also, (123)I-MIBG scintigraphy can detect cardiac denervation in ATTR patients before signs of amyloidosis are evident on echocardiography. (biomedsearch.com)
Surgical denervation1
Cholinergic denervation1
  • We conclude that cortical cholinergic denervation in PD and parkinsonian dementia is associated with decreased performance on tests of attentional and executive functioning. (springer.com)
Changes in the renal2
Nerves2
  • If the nerves lost to denervation are part of the neuronal communication to a specific function in the body then altered or a loss of physiological functioning can occur. (wikipedia.org)
  • Conclusions- CHEP offers a noninvasive approach to evaluate the degeneration of thermonociceptive nerves in diabetic neuropathy by providing physiological correlates of skin denervation and neuropathic pain. (diabetesjournals.org)
News for Medical Independent Sales Representatives and Medical Distributors: Renal Denervation Technology from St. Jude Medical...
News for Medical Independent Sales Representatives and Medical Distributors: Renal Denervation Technology from St. Jude Medical... (salesandmarketingnetwork.com)
Denervation - Wikipedia
Denervation - Wikipedia (en.wikipedia.org)
Dystonia: Symptoms, causes, and types
Dystonia: Symptoms, causes, and types (medicalnewstoday.com)
Mice with an autosomal dominant Charcot-Marie-Tooth type 2O disease mutation in both dynein alleles display severe moto-sensory...
Mice with an autosomal dominant Charcot-Marie-Tooth type 2O disease mutation in both dynein alleles display severe moto-sensory... (nature.com)
Wrist Arthritis Treatment & Management: Approach Considerations, Splinting and Pain Relief, Early and Late-Stage Surgical...
Wrist Arthritis Treatment & Management: Approach Considerations, Splinting and Pain Relief, Early and Late-Stage Surgical... (emedicine.medscape.com)
Developmental demands contribute to early neuromuscular degeneration in CMT2D mice | Cell Death & Disease
Developmental demands contribute to early neuromuscular degeneration in CMT2D mice | Cell Death & Disease (nature.com)
Renal denervation reduces recurrent AF after ablation | EurekAlert! Science News
Renal denervation reduces recurrent AF after ablation | EurekAlert! Science News (eurekalert.org)
Plus it
Plus it (jneurosci.org)
SPYRAL HTN-OFF MED: Reopens Renal-Denervation Conversation
SPYRAL HTN-OFF MED: Reopens Renal-Denervation Conversation (medscape.com)
Anesthesia | Boston Medical Center
Anesthesia | Boston Medical Center (bmc.org)
SYMPLICITY-FLEX: RDN Misses in Mildly Hypertensive Patients
SYMPLICITY-FLEX: RDN Misses in Mildly Hypertensive Patients (medscape.com)
Renal Denervation: Blood Pressure Benefit in New Meta-analysis
Renal Denervation: Blood Pressure Benefit in New Meta-analysis (medscape.com)
Pulmonology News, Research - Page 4
Pulmonology News, Research - Page 4 (news-medical.net)
Covidien Introduces OneShot Renal Denervation System
Covidien Introduces OneShot Renal Denervation System (medgadget.com)
Denervation suppresses gastric tumorigenesis | Science Translational Medicine
Denervation suppresses gastric tumorigenesis | Science Translational Medicine (stm.sciencemag.org)
Plus it
Plus it (jneurosci.org)
BHI CardioNomics
BHI CardioNomics (uhbristol.nhs.uk)
Renal Denervation | Springer for Research & Development
Renal Denervation | Springer for Research & Development (rd.springer.com)
Otsuka Finds Paradise in Renal Denervation Market | MDDI Online
Otsuka Finds Paradise in Renal Denervation Market | MDDI Online (mddionline.com)
Eligibility for Renal DenervationNovelty and Significance | Hypertension
Eligibility for Renal DenervationNovelty and Significance | Hypertension (hyper.ahajournals.org)
Bilateral Renal Artery Stenosis After Renal Denervation | Hypertension
Bilateral Renal Artery Stenosis After Renal Denervation | Hypertension (hyper.ahajournals.org)
PCR State-of-the-art lecture on 'The resurgence of renal denervation' | EurekAlert! Science News
PCR State-of-the-art lecture on 'The resurgence of renal denervation' | EurekAlert! Science News (eurekalert.org)
Molecular Pharmacology - Research database - University of Groningen
Molecular Pharmacology - Research database - University of Groningen (rug.nl)
Catheter News, Research - Page 3
Catheter News, Research - Page 3 (news-medical.net)
Frontiers | β-Adrenergic Receptor Stimulation and Alternans in the Border Zone of a Healed Infarct: An ex vivo Study and...
Frontiers | β-Adrenergic Receptor Stimulation and Alternans in the Border Zone of a Healed Infarct: An ex vivo Study and... (frontiersin.org)
Residual Sympathetic Responsiveness After Catheter-Based Renal Denervation | Hypertension
Residual Sympathetic Responsiveness After Catheter-Based Renal Denervation | Hypertension (hyper.ahajournals.org)
Deep brain stimulation | The Dystonia Society
Deep brain stimulation | The Dystonia Society (dystonia.org.uk)
Impaired Synaptic Vesicle Release and Immaturity of Neuromuscular Junctions in Spinal Muscular Atrophy Mice | Journal of...
Impaired Synaptic Vesicle Release and Immaturity of Neuromuscular Junctions in Spinal Muscular Atrophy Mice | Journal of... (jneurosci.org)
Botulinum and Tetanus Neurotoxins | Springer for Research & Development
Botulinum and Tetanus Neurotoxins | Springer for Research & Development (rd.springer.com)
Vessix V2 Renal Denervation System Receives CE Mark Approval
Vessix V2 Renal Denervation System Receives CE Mark Approval (medgadget.com)
December 1992 - Volume 90 - Issue 6 : Plastic and Reconstructive Surgery
December 1992 - Volume 90 - Issue 6 : Plastic and Reconstructive Surgery (journals.lww.com)
Renal Denervation After the SPYRAL HTN-OFF MED Trial | Hypertension
Renal Denervation After the SPYRAL HTN-OFF MED Trial | Hypertension (hyper.ahajournals.org)
Swiss Medical Weekly - Collection 2012/29-30
Swiss Medical Weekly - Collection 2012/29-30 (smw.ch)
Renal Denervation | Springer for Research & Development
Renal Denervation | Springer for Research & Development (rd.springer.com)