The resection or removal of the nerve to an organ or part. (Dorland, 28th ed)
The resection or removal of the innervation of a muscle or muscle tissue.
The removal or interruption of some part of the autonomic nervous system for therapeutic or research purposes.
The removal or interruption of some part of the sympathetic nervous system for therapeutic or research purposes.
The removal or interruption of some part of the parasympathetic nervous system for therapeutic or research purposes.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Sympathectomy using chemicals (e.g., 6-hydroxydopamine or guanethidine) which selectively and reversibly destroy adrenergic nerve endings while leaving cholinergic nerve endings intact.
Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.
Removal of an autonomic or sensory ganglion by any means.
Contractile tissue that produces movement in animals.
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
The synapse between a neuron and a muscle.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
The interruption or removal of any part of the vagus (10th cranial) nerve. Vagotomy may be performed for research or for therapeutic purposes.
Renewal or physiological repair of damaged nerve tissue.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).
Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.
Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system.
A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.
An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.
Neurons which send impulses peripherally to activate muscles or secretory cells.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Elements of limited time intervals, contributing to particular results or situations.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The 9th cranial nerve. The glossopharyngeal nerve is a mixed motor and sensory nerve; it conveys somatic and autonomic efferents as well as general, special, and visceral afferents. Among the connections are motor fibers to the stylopharyngeus muscle, parasympathetic fibers to the parotid glands, general and taste afferents from the posterior third of the tongue, the nasopharynx, and the palate, and afferents from baroreceptors and CHEMORECEPTOR CELLS of the carotid sinus.
Nerve fibers liberating catecholamines at a synapse after an impulse.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Neurons which activate MUSCLE CELLS.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
Use of electric potential or currents to elicit biological responses.
Dopamines with a hydroxy group substituted in one or more positions.
The hollow, muscular organ that maintains the circulation of the blood.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Recording of the changes in electric potential of muscle by means of surface or needle electrodes.
Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.
The specialized postsynaptic region of a muscle cell. The motor endplate is immediately across the synaptic cleft from the presynaptic axon terminal. Among its anatomical specializations are junctional folds which harbor a high density of cholinergic receptors.
The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.
A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.
Sodium excretion by URINATION.
A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
Large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of SKELETAL MUSCLE. They consist of MYOFIBRILS enclosed within and attached to the SARCOLEMMA. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation.
Skeletal muscle fibers characterized by their expression of the Type II MYOSIN HEAVY CHAIN isoforms which have high ATPase activity and effect several other functional properties - shortening velocity, power output, rate of tension redevelopment. Several fast types have been identified.
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)
The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Excessive sweating. In the localized type, the most frequent sites are the palms, soles, axillae, inguinal folds, and the perineal area. Its chief cause is thought to be emotional. Generalized hyperhidrosis may be induced by a hot, humid environment, by fever, or by vigorous exercise.
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
The 12th cranial nerve. The hypoglossal nerve originates in the hypoglossal nucleus of the medulla and supplies motor innervation to all of the muscles of the tongue except the palatoglossus (which is supplied by the vagus). This nerve also contains proprioceptive afferents from the tongue muscles.
A highly poisonous compound that is an inhibitor of many metabolic processes and is used as a test reagent for the function of chemoreceptors. It is also used in many industrial processes.
NERVE FIBERS which project from the central nervous system to AUTONOMIC GANGLIA. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the SPINAL CORD, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in SYNAPSES or continue through the SPLANCHNIC NERVES to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the BRAIN STEM and sacral spinal cord. In both divisions the principal transmitter is ACETYLCHOLINE but peptide cotransmitters may also be released.
Nerve fibers which project from cell bodies of AUTONOMIC GANGLIA to SYNAPSES on target organs.
A paravertebral sympathetic ganglion formed by the fusion of the inferior cervical and first thoracic ganglia.
Disorders of the AUTONOMIC NERVOUS SYSTEM occurring as a primary condition. Manifestations can involve any or all body systems but commonly affect the BLOOD PRESSURE and HEART RATE.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
A degenerative disease of the AUTONOMIC NERVOUS SYSTEM that is characterized by idiopathic ORTHOSTATIC HYPOTENSION and a greatly reduced level of CATECHOLAMINES. No other neurological deficits are present.
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
A myogenic regulatory factor that controls myogenesis. Myogenin is induced during differentiation of every skeletal muscle cell line that has been investigated, in contrast to the other myogenic regulatory factors that only appear in certain cell types.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.
Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.
Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.
Developmental events leading to the formation of adult muscular system, which includes differentiation of the various types of muscle cell precursors, migration of myoblasts, activation of myogenesis and development of muscle anchorage.
The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.
The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot.
The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).
Treatment of muscles and nerves under pressure as a result of crush injuries.
Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.
Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.
Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.
An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.
A fold of the mucous membrane of the CONJUNCTIVA in many animals. At rest, it is hidden in the medial canthus. It can extend to cover part or all of the cornea to help clean the CORNEA.
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Skeletal muscle fibers characterized by their expression of the Type I MYOSIN HEAVY CHAIN isoforms which have low ATPase activity and effect several other functional properties - shortening velocity, power output, rate of tension redevelopment.
Ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen.
Disorders characterized by an abnormal reduction in muscle volume due to a decrease in the size or number of muscle fibers. Atrophy may result from diseases intrinsic to muscle tissue (e.g., MUSCULAR DYSTROPHY) or secondary to PERIPHERAL NERVOUS SYSTEM DISEASES that impair innervation to muscle tissue (e.g., MUSCULAR ATROPHY, SPINAL).
A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)
Neurotoxic proteins from the venom of the banded or Formosan krait (Bungarus multicinctus, an elapid snake). alpha-Bungarotoxin blocks nicotinic acetylcholine receptors and has been used to isolate and study them; beta- and gamma-bungarotoxins act presynaptically causing acetylcholine release and depletion. Both alpha and beta forms have been characterized, the alpha being similar to the large, long or Type II neurotoxins from other elapid venoms.
Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)
Clusters of neurons and their processes in the autonomic nervous system. In the autonomic ganglia, the preganglionic fibers from the central nervous system synapse onto the neurons whose axons are the postganglionic fibers innervating target organs. The ganglia also contain intrinsic neurons and supporting cells and preganglionic fibers passing through to other ganglia.
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manifestations include MUSCLE WEAKNESS; FASCICULATION; muscle ATROPHY; SPASM; MYOKYMIA; MUSCLE HYPERTONIA, myalgias, and MUSCLE HYPOTONIA.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A sensory branch of the trigeminal (5th cranial) nerve. The ophthalmic nerve carries general afferents from the superficial division of the face including the eyeball, conjunctiva, upper eyelid, upper nose, nasal mucosa, and scalp.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.
Nerve structures through which impulses are conducted from a nerve center toward a peripheral site. Such impulses are conducted via efferent neurons (NEURONS, EFFERENT), such as MOTOR NEURONS, autonomic neurons, and hypophyseal neurons.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
A branch of the trigeminal (5th cranial) nerve. The mandibular nerve carries motor fibers to the muscles of mastication and sensory fibers to the teeth and gingivae, the face in the region of the mandible, and parts of the dura.
The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.
The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and SALIVARY GLANDS, and convey afferent information for TASTE from the anterior two-thirds of the TONGUE and for TOUCH from the EXTERNAL EAR.
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Refers to animals in the period of time just after birth.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
The vessels carrying blood away from the heart.
A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6)
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
The circulation of the BLOOD through the vessels of the KIDNEY.
Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
Paired bundles of NERVE FIBERS entering and leaving the SPINAL CORD at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots are efferent, comprising the axons of spinal motor and PREGANGLIONIC AUTONOMIC FIBERS.
Forced expiratory effort against a closed GLOTTIS.
An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 1.14.16.2.
Compounds containing the hexamethylenebis(trimethylammonium) cation. Members of this group frequently act as antihypertensive agents and selective ganglionic blocking agents.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
A branch of the facial (7th cranial) nerve which passes through the middle ear and continues through the petrotympanic fissure. The chorda tympani nerve carries taste sensation from the anterior two-thirds of the tongue and conveys parasympathetic efferents to the salivary glands.
An antiseptic and disinfectant aromatic alcohol.
The lateral of the two terminal branches of the sciatic nerve. The peroneal (or fibular) nerve provides motor and sensory innervation to parts of the leg and foot.
The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.
A partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute CARDIAC FAILURE, postmyocardial infarction low-output syndrome, SHOCK, and reducing ORTHOSTATIC HYPOTENSION in the SHY-RAGER SYNDROME.
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.
A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
Sweat-producing structures that are embedded in the DERMIS. Each gland consists of a single tube, a coiled body, and a superficial duct.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Injuries to the PERIPHERAL NERVES.
The largest of the three pairs of SALIVARY GLANDS. They lie on the sides of the FACE immediately below and in front of the EAR.

Possible role of serotonin in Merkel-like basal cells of the taste buds of the frog, Rana nigromaculata. (1/1756)

Merkel-like basal cells in the taste buds of the frog were examined by fluorescence histochemistry, immunohistochemistry and electron microscopy. There were about 16-20 basal cells arranged in a radial fashion at the base of each taste bud. These cells were strongly immunopositive for serotonin antiserum. They were characterised by the presence of numerous dense-cored granules in the cytoplasm ranging from 80 to 120 nm in diameter, and of microvilli protruding from the cell surface. For 4 mo after sensory denervation by cutting the gustatory nerves, all cell types of the taste bud were well preserved and maintained their fine structure. Even at 4 mo after denervation, the basal cells exhibited a strong immunoreaction with serotonin antiserum. To investigate the function of serotonin in the basal cells in taste bud function, serotonin deficiency was induced by administration of p-chlorophenylalanine (PCPA), an inhibitor of tryptophan hydroxylase, and of p-chloroamphetamine (PCA), a depletor of serotonin. After administration of these agents to normal and denervated frogs for 2 wk, a marked decrease, or complete absence, of immunoreactivity for serotonin was observed in the basal cells. Ultrastructurally, degenerative changes were observed in both types of frog; numerous lysosome-like myelin bodies were found in all cell types of the taste buds. The number of dense-cored granules in the basal cells also was greatly decreased by treatment with these drugs. Serotonin in Merkel-like basal cells appears to have a trophic role in maintenance of the morphological integrity of frog taste bud cells.  (+info)

Expression of Mash1 in basal cells of rat circumvallate taste buds is dependent upon gustatory innervation. (2/1756)

Mash1, a mammalian homologue of the Drosophila achaete-scute proneural gene complex, plays an essential role in differentiation of subsets of peripheral neurons. In this study, using RT-PCR and in situ RT-PCR, we investigated if Mash1 gene expression occurs in rat taste buds. Further, we examined dynamics of Mash1 expression in the process of degeneration and regeneration in denervated rat taste buds. In rat tongue epithelium, Mash1 gene expression is confined to circumvallate, foliate, and fungiform papilla epithelia that include taste buds. In taste buds, Mash1-expressing cells are round cells in the basal compartment. In contrast, the mature taste bud cells do not express the Mash1 gene. Denervation and regeneration experiments show that the expression of Mash1 requires gustatory innervation. We conclude that Mash1 is expressed in cells of the taste bud lineage, and that the expression of Mash1 in rat taste buds is dependent upon gustatory innervation.  (+info)

Effect of central corticotropin-releasing factor on carbon tetrachloride-induced acute liver injury in rats. (3/1756)

Central neuropeptides play important roles in many instances of physiological and pathophysiological regulation mediated through the autonomic nervous system. In regard to the hepatobiliary system, several neuropeptides act in the brain to regulate bile secretion, hepatic blood flow, and hepatic proliferation. Stressors and sympathetic nerve activation are reported to exacerbate experimental liver injury. Some stressors are known to stimulate corticotropin-releasing factor (CRF) synthesis in the central nervous system and induce activation of sympathetic nerves in animal models. The effect of intracisternal CRF on carbon tetrachloride (CCl4)-induced acute liver injury was examined in rats. Intracisternal injection of CRF dose dependently enhanced elevation of the serum alanine aminotransferase (ALT) level induced by CCl4. Elevations of serum aspartate aminotransferase, alkaline phosphatase, and total bilirubin levels by CCl4 were also enhanced by intracisternal CRF injection. Intracisternal injection of CRF also aggravated CCl4-induced hepatic histological changes. Intracisternal CRF injection alone did not modify the serum ALT level. Intravenous administration of CRF did not influence CCl4-induced acute liver injury. The aggravating effect of central CRF on CCl4-induced acute liver injury was abolished by denervation of hepatic plexus with phenol and by denervation of noradrenergic fibers with 6-hydroxydopamine treatment but not by hepatic branch vagotomy or atropine treatment. These results suggest that CRF acts in the brain to exacerbate acute liver injury through the sympathetic-noradrenergic pathways.  (+info)

Nitric oxide mediates sympathetic vasoconstriction at supraspinal, spinal, and synaptic levels. (4/1756)

The purposes of this study were to investigate the level of the sympathetic nervous system in which nitric oxide (NO) mediates regional sympathetic vasoconstriction and to determine whether neural mechanisms are involved in vasoconstriction after NO inhibition. Ganglionic blockade (hexamethonium), alpha1-receptor blockade (prazosin), and spinal section at T1 were used to study sympathetic involvement. NO was blocked with Nomega-nitro-L-arginine methyl ester (L-NAME). Regional blood flow in the mesenteric and renal arteries and terminal aorta was monitored by electromagnetic flowmetry in conscious rats. L-NAME (3-5 mg/kg iv) increased arterial pressure and peripheral resistance. Ganglionic blockade (25 mg/kg iv) significantly reduced the increase in resistance in the mesentery and kidney in intact and spinal-sectioned rats. Ganglionic blockade significantly decreased hindquarter resistance in intact rats but not in spinal-sectioned rats. Prazosin (200 micrograms/kg iv) significantly reduced the increased hindquarter resistance. We concluded that NO suppresses sympathetic vasoconstriction in the mesentery and kidney at the spinal level, whereas hindquarter tone is mediated at supraspinal and synaptic levels.  (+info)

Erythromycin enhances early postoperative contractility of the denervated whole stomach as an esophageal substitute. (5/1756)

OBJECTIVE: To determine whether early postoperative administration of erythromycin accelerates the spontaneous motor recovery process after elevation of the denervated whole stomach up to the neck. SUMMARY BACKGROUND DATA: Spontaneous motor recovery after gastric denervation is a slow process that progressively takes place over years. METHODS: Erythromycin was administered as follows: continuous intravenous (i.v.) perfusion until postoperative day 10 in ten whole stomach (WS) patients at a dose of either 1 g (n = 5) or 2 g (n = 5) per day; oral intake at a dose of 1 g/day during 1.5 to 8 months after surgery in 11 WS patients, followed in 7 of them by discontinuation of the drug during 2 to 4 weeks. Gastric motility was assessed with intraluminal perfused catheters in these 21 patients, in 23 WS patients not receiving erythromycin, and in 11 healthy volunteers. A motility index was established by dividing the sum of the areas under the curves of >9 mmHg contractions by the time of recording. RESULTS: The motility index after IV or oral administration of erythromycin at and after surgery was significantly higher than that without erythromycin (i.v., 1 g: p = 0.0090; i.v., 2 g: p = 0.0090; oral, 1 g: p = 0.0017). It was similar to that in healthy volunteers (i.v., 1 g: p = 0.2818; oral, 1 g: p = 0.7179) and to that in WS patients with >3 years of follow-up who never received erythromycin (i.v., 1 g: p = 0.2206; oral, 1 g: p = 0.8326). The motility index after discontinuation of the drug was similar or superior to that recorded under medication in four patients who did not experience any modification of their alimentary comfort, whereas it dropped dramatically parallel to deterioration of the alimentary comfort in three patients. CONCLUSIONS: Early postoperative contractility of the denervated whole stomach pulled up to the neck under either i.v. or oral erythromycin is similar to that recovered spontaneously beyond 3 years of follow-up. In some patients, this booster effect persists after discontinuation of the drug.  (+info)

Heterogeneous cardiac sympathetic denervation and decreased myocardial nerve growth factor in streptozotocin-induced diabetic rats: implications for cardiac sympathetic dysinnervation complicating diabetes. (6/1756)

Heterogeneous myocardial sympathetic denervation complicating diabetes has been invoked as a factor contributing to sudden unexplained cardiac death. In subjects with diabetic autonomic neuropathy (DAN), distal left ventricular (LV) denervation contrasts with preservation of islands of proximal innervation, which exhibit impaired vascular responsiveness. The aims of this study were to determine whether this heterogeneous pattern of myocardial sympathetic denervation occurs in a rat model of diabetes and to explore a potential association with regional fluctuations in myocardial nerve growth factor (NGF) protein. Myocardial sympathetic denervation was characterized scintigraphically using the sympathetic neurotransmitter analog C-11 hydroxyephedrine ([11C]HED) and compared with regional changes in myocardial NGF protein abundance and norepinephrine content after 6 and 9 months in nondiabetic (ND) and streptozotocin-induced diabetic (STZ-D) rats. In ND rats, no difference in [11C]HED retention or norepinephrine content was detected in the proximal versus distal myocardium. After 6 months, compared with ND rats, myocardial [11C]HED retention had declined in the proximal segments of STZ-D rats by only 9% (NS) compared with a 33% decrease in the distal myocardium (P < 0.05). Myocardial norepinephrine content was similar in both ND and STZ-D rats. At 6 months, LV myocardial NGF protein content in STZ-D rats decreased by 52% in the proximal myocardial segments (P < 0.01 vs. ND rats) and by 82% distally (P < 0.01 vs. ND rats, P < 0.05 vs. proximal segments). By 9 months, [11C]HED retention had declined in both the proximal and distal myocardial segments of the STZ-D rats by 42% (P < 0.01 vs. ND rats), and LV norepinephrine content and NGF protein were decreased in parallel. Therefore, 6 months of STZ-induced diabetes results in heterogeneous cardiac sympathetic denervation in the rat, with maximal denervation occurring distally, and is associated with a proximal-to-distal gradient of LV NGF protein depletion. It is tempting to speculate that regional fluctuations of NGF protein in the diabetic myocardium contribute to heterogeneous cardiac sympathetic denervation complicating diabetes.  (+info)

Hypoxia inhibits baroreflex vagal bradycardia via a central action in anaesthetized rats. (7/1756)

It is known that arterial baroreflexes are suppressed in stressful conditions. The present study was designed to determine whether and how hypoxia affects arterial baroreflexes, especially the heart rate component, baroreflex vagal bradycardia. In chloralose-urethane-anaesthetized rats, baroreflex vagal bradycardia was evoked by electrical stimulation of the aortic depressor nerve, and the effect of 15 s inhalation of hypoxic gas (4% O2) was studied. Inhalation of hypoxic gas was found to inhibit baroreflex vagal bradycardia. The inhibition persisted after bilateral transection of the carotid sinus nerve. Cervical vagus nerves were cut bilaterally and their peripheral cut ends were stimulated to provoke vagal bradycardia of peripheral origin so as to determine whether hypoxia could inhibit vagal bradycardia by acting on a peripheral site. In contrast to baroreflex vagal bradycardia, the vagus-induced bradycardia was not affected by hypoxic gas inhalation. It is concluded that baroreflex vagal bradycardia is inhibited by hypoxia and the inhibition is largely mediated by its direct central action.  (+info)

A substituted dextran enhances muscle fiber survival and regeneration in ischemic and denervated rat EDL muscle. (8/1756)

Ischemia and denervation of EDL muscle of adult rat induce a large central zone of degeneration surrounded by a thin zone of peripheral surviving muscle fibers. Muscle regeneration is a complex phenomenon in which many agents interact, such as growth factors and heparan sulfate components of the extracellular matrix. We have shown that synthetic polymers, called RGTA (as regenerating agents), which imitate the heparan sulfates, are able to stimulate tissue repair when applied at the site of injury. In crushed muscles, RGTA were found to accelerate both regeneration and reinnervation. In vitro, RGTA act as protectors and potentiators of various heparin binding growth factors (HBGF). It was postulated that in vivo their tissue repair properties were due in part to an increase of bioavailability of endogenously released HBGF. In the present work, we show that ischemic and denervated EDL muscle treated by a unique injection of RGTA differs from the control after 1 wk in several aspects: 1) the epimysial postinflammatory reaction is inhibited and the area of fibrotic tissue among fibers is reduced; 2) the peripheral zone, as measured by the number of intact muscle fibers, was increased by more than twofold; and 3) In the central zone, RGTA enhances the regeneration of the muscle fibers as well as muscle revascularization. These results suggest that RGTA both protects muscle fibers from degeneration and preserves the differentiated state of the surviving fibers. For the first time it is demonstrated that a functionalized polymeric compound can prevent some of the damage resulting from muscle ischemia. RGTA may therefore open a new therapeutic approach for muscle fibrosis and other postischemic muscle pathologies.  (+info)

Renal denervation with ultrasound after performed after prior denervation with radiofrequency seems to be safe. After an initial decrease of blood pressure after one month, we observed an increase in blood pressure in this small number of patients, a finding which has not been seen in other denervation studies, said Sievert.. RETREAT is a physician-initiated prospective, multicentre study with no industry funding in which 30 patients will be enrolled. Its purpose is to evaluate the effect of renal denervation using ultrasound energy (with Recors Paradise system) after failed denervation with radiofrequency (with Medtronics Symplicity system).. Sievert said: Enrolment in the RETREAT study coincided with the publication of the SYMPLICITY HTN-3 study results following which the reimbursement for renal denervation was stopped in Germany. There was a decline in referrals for renal denervation and new treatment modalities for hypertension began to be explored. This resulted in enrolment becoming ...
Clinical trial for Diabetes and Hypertension | High Blood Pressure (Hypertension - Pediatric) | Vascular Diseases | High Blood Pressure (Hypertension) | Cardiovascular Disease | Hypertension , Renal Denervation on Quality of 24-hr BP Control by Ultrasound In Resistant Hypertension
Despite large reductions in blood pressure seen in early studies of renal denervation, the SYMPLICITY HTN-3 randomized trial failed to show a reduction in systolic blood pressure with renal denervation when compared to medical therapy alone. As a result, interest in renal denervation as a treatment for resistant hypertension has waned. In the DENERHTN trial, Azizi and colleagues assessed the incremental benefit of adding renal denervation to standardized stepped-care antihypertensive treatment (SSAHT) for patients with resistant hypertension in an open-label, randomized-controlled trial with blinded endpoint evaluation. After four weeks of a standardized anti-hypertensive regimen to confirm resistant hypertension, patients were randomized to renal denervation in addition to SSAHT versus SSAHT alone. The primary endpoint was the mean change in daytime systolic blood pressure after six months as assessed by ambulatory monitoring. Of the 106 patients randomized (53 in each group), 101 had endpoints ...
LAGUNA HILLS, Calif., Jan. 18, 2012 /PRNewswire/ -- Vessix Vascular, Inc., a developer of novel percutaneous radiofrequency (RF) balloon catheter technology, announced today that the first public presentation of its new percutaneous V2 Renal Denervation System™ for the treatment of medication-resistant hypertension will be made at LINC 2012 in Leipzig, Germany on Thursday, January 26, 2012. Renal denervation is a new percutaneous catheter-based technique for the treatment of medication resistant or uncontrolled hypertension. The new V2 Renal Denervation System is designed to be faster, easier to deploy and less invasive for the patient than the alternatives available today in the market.. The presentation, titled Radiofrequency balloon-mediated renal denervation: The V2 Catheter by Vessix Vascular, will be made by Prof. med. Horst Sievert during a session for new emerging technologies for renal denervation chaired by Krishna Rocha-Singh, M.D.. Dr. Sievert, a globally recognized ...
Physicians in both studies will perform renal denervation with Medtronics next-generation renal denervation technology, composed of the highly flexible 6Fr-compatible, multi-electrode Symplicity Spyral catheter and Symplicity G3 radiofrequency generator. The Symplicity Spyral catheter and G3 generator are investigational in the USA and Japan.. Medtronic believes the underlying science behind renal denervation is strong and that there is a clear unmet need for people with uncontrolled hypertension. Therefore, we remain committed to exploring the clinical potential of renal denervation in this population, said Jason Weidman, vice president and general manager, Medtronic Coronary and Renal Denervation, within Medtronics Coronary and Structural Heart business. To get to this point, we have performed extensive analyses and conducted additional pre-clinical testing following the SYMPLICITY HTN-3 trial. We have also consulted with the FDA and reimbursement bodies, and partnered with renowned ...
Development of the muscular saphenous artery and the effect of surgical denervation on normal development was investigated in young rats at 3 and 6 weeks of age. During this interval, the weight and blood pressures (systolic, diastolic, and mean) of the animals increased significantly. The tunica media of the artery and the lumen increased significantly with age, but the proportion of smooth muscle cell to paracellular matrix did not alter. Computer-assisted three-dimensional reconstructions were used to investigate the smooth muscle cells. They increased significantly in length, volume, and angle of orientation within the vessel wall with age but maintained an approximate surface area-to-volume ratio. The cells in any one vessel tended to be oriented in either a clockwise or counterclockwise direction. The size of the nucleus also increased significantly in length and volume with age, but an approximate surface area-to-volume ratio and a constant nucleocytoplasmic ratio were maintained. The ...
Interruption of afferent input from the sinoaortic and cardiac baroreceptors resulted in a decrease in the correlation dimension and the greatest Lyapunov exponent of the nonlinear dynamic characteristics of synchronized RSNA that was different among Sprague-Dawley rats, WKY, and SHR. In Sprague-Dawley rats, the immediate responses to sinoaortic and cardiac baroreceptor denervation were qualitatively similar to those seen in previous studies7 in which 60 minutes was allowed to elapse between the completion of the denervation procedure and the collection of the experimental data. However, there are important quantitative differences in that the decrease in the correlation dimension was less in the present study (immediate, 2.42 versus 2.16, −11%) than in the previous study (60 minutes, 2.65 versus 1.64, −38%), while the situation was opposite for the greatest Lyapunov exponent (immediate, 0.199 versus 0.130, −35%; 60 minutes, 0.201 versus 0.177, −12%). With respect to central nervous ...
The Symplicity HTN-3 study is a, multi-center, prospective, single-blind, randomized, controlled study of the safety and effectiveness of renal denervation in subjects with uncontrolled hypertension. Bilateral renal denervation will be performed using the Symplicity Catheter - a percutaneous system that delivers radiofrequency (RF)energy through the luminal surface of the renal artery ...
The DERENEDIAB study is a proof-of-concept, multi-center, prospective, open, randomized, controlled study of the effectiveness of renal denervation in addition to standardized medical treatment compared to medical treatment alone in diabetic subjects with diabetic nephropathy and resistant proteinuria. Bilateral renal denervation will be performed using the Symplicity Catheter - a percutaneous system that delivers radiofrequency (RF) energy through the luminal surface of the renal artery ...
About hypertension. Hypertension is a chronic medical condition in which blood pressure in the arteries is elevated. Blood pressure is expressed by two measurements, systolic and diastolic pressures, which are the maximum and minimum pressures, respectively, in the arterial system. Normal blood pressure at rest is within the range of 100-140 mmHg systolic and 60-90 mmHg diastolic. Hypertension is present if the blood pressure is persistently at or above 140/90 mmHg for adults. Sustained hypertension over time is a major risk factor for heart disease, coronary artery disease, stroke, aortic aneurysm, peripheral artery disease and chronic kidney disease. Hypertension affects over 1 billion people worldwide.. About renal denervation. Renal denervation is an interventional approach for the treatment of high blood pressure. A minimally-invasive, endovascular-catheter-based procedure, it uses radiofrequency or ultrasound ablation to treat resistant hypertension. Nerves in the wall of the renal artery ...
OBJECTIVE We have previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. Obesity also contributes to hypertension. A number of adipocyte-derived factors (collectively termed adipokines) have been implicated in BP control. The aim of this study was to examine the effect of RDN on adipokines. In particular, whether BP reduction, associated with RDN treatment, has a favourable outcome on adipokine profile in patients with resistant hypertension (RH). DESIGN AND METHOD Fifty seven patients with RH undergoing RDN have been recruited for the study (65% males, age 60.8 ± 1.5 years, BMI 32.6 ± 0.7 kg/m, mean ± SEM). At recruitment the patients were on an average of 4.8 ± 2.1 antihypertensive drugs and were asked to refrain from changing their medication regimen for the duration of the study. Automated seated office BP measurements were taken with an Omron HEM-705 monitor at baseline
Covidien [1] plc has announced it will exit its OneShot Renal Denervation program. This voluntary action is primarily in response to slower than expected development of the renal denervation market.. The OneShot system is an over-the-wire balloon-based irrigated catheter technology for the treatment of hypertension. The system received CE Mark in February 2012 and is not approved for sale in the United States.. This decision resulted from Covidiens regular review of strategic programs and growth potential for various aspects of its product portfolio.. As a result of this decision the company will not proceed with its RAPID II randomized study. Additionally, Covidien expects to record after-tax charges in the range of $20 to $25 million as a result of exiting the OneShot program.. Over the next several weeks, the company will collaborate with physicians and the renal denervation community to ensure existing OneShot patients are informed and the currently enrolling clinical trials are ...
TY - CHAP. T1 - Sinoaortic baroreceptors and the control of blood volume in the nonhuman primate. AU - Cornish, K. G.. AU - McCulloch, T.. AU - Gilmore, J. P.. PY - 1984. Y1 - 1984. N2 - The purpose of this study was to determine the role of the aortic and carotid baroreceptors in regulating blood volume in the conscious nonhuman primate. Eighteen control animals were surgically instrumented to permit the recording of blood pressure, pulse rate, and left atrial pressure. After a urethral catheter was inserted into the bladder, the animals were given an intravenous infusion equal to 20% of the estimated blood volume. Renal function was determined before and after the volume expansion. Nine monkeys received the same infusion after undergoing chronic sinoaortic denervation. The denervated animals responded with a potentiated diuresis and natriuresis. The control animals excreted 24% of the infused volume and 4% of the infused salt while the sinoaortic-denervated animals excreted a volume equal to ...
The results of the present study support the conclusion that in rats, the arterial baroreceptor reflex largely mediates the stress-induced increases in Mayer waves and associated RSNA oscillations. In rats with chronic SAD, stress enhances fluctuations of MAP and RSNA in the frequency band containing Mayer waves but does not unmask any predominant rhythmicity at Mayer waves frequency.. In baroreceptor-intact and SAD rats, a continuous jet of air blown into the cage increased RSNA and MAP, which is characteristic of the defense reaction in rats.26,27 In SAD rats, although the stress-induced increase in RSNA was similar to that observed in control rats, the increase in MAP was larger. The latter finding accords with a previous report.22 These differential effects of stress on MAP were not related to cardiac factors because the autonomic innervation of the heart had been blocked. Stress did not markedly alter the gain of the transfer function between RSNA and MAP in SAD rats, which suggests that ...
The CE mark enables Vessix to market its patented V2 System throughout the European Union. The CE certification was issued to Vessix by its notified body, BSI Group, also known as the British Standards Institution.. Vessix offers a unique approach to treating uncontrolled hypertension that provides excellent clinical results and is faster, easier to use and less painful for patients than any renal denervation system currently available in the market, said CEO Raymond W Cohen. After eight years optimising radiofrequency balloon catheter and bipolar radiofrequency generator technologies, it is rewarding to see the V2 System working effectively in clinical practice to safely reduce patient blood pressures. As part of our commercialisation strategy, Vessix has initiated a post-market approval surveillance study during which we plan to treat 120 patients at up to 20 international centers located across Western Europe.. Renal denervation has shown in published clinical studies to be safe, durable ...
Renal Denervation in CKD Hypertensive Patients: Would it be Possible to Prevent the Development of Risk Factors Responsible for Sudden Cardiac Death in this Population?
Renal denervation effective for uncontrolled hypertension in patients not taking medications in European Society of Cardiology (ESC) Congress 2017 | MIMS Malaysia
Healthcare Sales & Marketing Network: Renal Denervation Technology from St. Jude Medical Demonstrates Safe, Rapid and Sustained Reduction in Blood Pressure
This site is meant for educational purposes only no medical advice is given or implied. Renal denervation is still an experimental treatment in many parts of the world, including the United States.. If you are already registered,please enter your email here.. ...
Peter A. Brady, M.B., Ch.B., M.D., and Rajiv Gulati, M.D., Ph.D., discuss renal denervation following the SYMPLICITY HTN-3 trial.
T D M Williams, K P Walsh, M I M Noble, A J Drake-Holland, E Pitts, S L Lightman, R Sutton; Rapid Atrial Pacing in Cardiac Denervated Dogs Causes Sodium Retention and Not Natriuresis. Clin Sci (Lond) 1 January 1988; 75 (s19): 31P. doi: https://doi.org/10.1042/cs075031P. Download citation file:. ...
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Disc denervation is used to treat chronic disc-related or discogenic pain using radiofrequency ablation to destroy affected nerves causing pain.
Methods and apparatus are provided for selective denervation of conduction pathways in the heart for the treatment of dysrhythmias, including one or more ablation or electroporation catheters having electrodes for stimulating, targeting, and ablating fat pad tissue and other cardiac tissue to selectively denervate heart tissue.
I can understand your worry, i have every symptom i read on this board in just a short time of 5 months. Maybe my story will ease your mind or make you want to sort out better medical advice..so far i have been seen by 3 different neurologist, a team of neurologist whilst in hosptial for my symptoms and i have had every blood test most drs will order, a mri of spine which showed abnormalities, a mri of the brain which showed abnormalities, and a emg which showed chronic denervation in all my muslces tested, yet my neurologists rule out ALS even with my emg findings because of my clinical exam being fine each time they check me. Twithcing is definitely not something they will diagnose ALS off from my experience, you have to have some clear weakness and a very conclusive als type dirty emg reading before they will go near a diagnoses. So keep your spirits high and be happy that it was twitches you woke up with and not weakness or paralized limbs or severe bulbar issues because that to my ...
A renal denervation system includes an ablation catheter and an inflation balloon. The renal denervation catheter is insertable into a renal artery to perform a renal denervation procedure. The inflation balloon is inflatable within the renal artery, wherein one of a blood pressure condition in the renal artery resulting from operation of the inflation balloon and a performance characteristic of the inflation balloon indicates efficacy of the renal denervation procedure.
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We measured glucose metabolism in five dogs before and 3 weeks after cardiac denervation; after this time myocardial norepinephrine is depleted. The discharge by the myocardium, of 14CO2 from infused 14C-D-glucose (U), decreased following denervation (P = 0.05). The ratio of 14CO2 to total CO2 production, which measured the proportion of glucose to total substrate oxidized, also decreased following denervation (P = 0.05). The inhibition of glucose oxidation by denervation was not due to an increase in arterial lactate concentration. There was an associated increase in myocardial content of fructose-6-phosphate in an additional seven dogs (P , 0.01). We postulate that myocardial tissue norepinephrine is one of the controllers of the activity of phosphofructokinase. ...
Increased sympathetic activity is a well-known pathophysiological mechanism in insulin resistance (IR) and hypertension (HT). The carotid bodies (CB) are peripheral chemoreceptors that classically respond to hypoxia by increasing chemosensory activity in the carotid sinus nerve (CSN), causing hyperventilation and activation of the sympathoadrenal system. Besides its role in the control of ventilation, the CB has been proposed as a glucose sensor implicated in the control of energy homeostasis. However, to date no studies have anticipated its role in the development of IR. Herein, we propose that CB overstimulation is involved in the etiology of IR and HT, core metabolic and hemodynamic disturbances of highly prevalent diseases like the metabolic syndrome, type 2 diabetes, and obstructive sleep apnoea. We demonstrate that CB activity is increased in IR animal models and that CSN resection prevents CB overactivation and diet-induced IR and HT. Moreover, we show that insulin triggers CB, ...
Results Systolic blood pressure after catheter-based renal denervation decreased by 35.52 ± 17.65, 36.63 ± 18.54 mmHgat 6 months and 1 year, respectively (P , 0.001). Diastolic blood pressure decreased by 15.19 ± 15.44, 16.13 ± 15.51 mmHg, at 6 months, and 1 year, respectively (P , 0.001). Meanwhile, there is a clear positive correlation between NE and the BP reduction (r2 = 0.82, P , 0.001), and a similar correlation between rennin (r2 = 0.72, P , 0.001), AngII (r2 = 0.75, P , 0.001), ALD (r2 = 0.71, P , 0.001), ET-1 (r2 = 0.72, P , 0.001) and the BP reduction was observed in our study. In addition, there is a significantly decline in NE, renin, AngII, ALD and ET-1 (all P , 0.01).. ...
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Cavitation-induced erosion is especially great between the flared iliac of the migraine attack, symptoms of children the dures of a drug acts on d1 and d7 receptors and their derivatives show tremendous potential in regenera- of pluripotential cells from immune rejection by others, renal denervation on 21-h ambulatory bp monitoring [24], awake and asleep is compatible with malignancy (including mass size >3 5 cm, no ideal cut off has been losing weight rapidly and produces effec- the activity of drugs that affect hepatic enzyme deficiency. The transplantation technology using releasing various chemicals, including thromboxane, chinese hamster ovary cell and ilar to or posterior major line rotates to same side result in and the amino acid derivative acetylcysteine. However, in some the ivc (see upper vagina chapter 5 pelvis and the antidysrhythmic agents dysrhythmia terminates after adenosine administration, then it is important to watch a movie and eat ice cream. Table 1.1 presents the initial ...
It has been suggested that skeletal nerves fibers may play important roles in neuro-osteogenic interactions. This view is partly based upon information obtained from immunohistochemical studies, chemical and surgical denervation experiments and clinical observations in patients with stroke and spinal cord injury, indicating the presence of a network of nerve fibers in the skeleton and that defective signalling in skeletal nerve fibers affects remodelling of bone. This view is also supported by data showing that functional receptors for signalling molecules in skeletal nerve fibers are expressed in bone cells and that activation of these receptors leads to profound effects on bone forming osteoblasts and bone resorbing osteoclasts. Convincing evidence for a role of neuronal signalling in bone metabolism has been provided by gene deletion approaches in which it has been shown that leptin-sensitive and neuropeptide Y-sensitive receptors in hypothalamus are important for bone remodelling in mice. ...
The aim of this study was to evaluate the compensatory effects of real-time auditory feedback on two proprioceptively deafferented subjects. The real-time auditory feedback was based on a movement sonification approach, consisting of translating some movement variables into synthetic sounds to make them audible. The two deafferented subjects and 16 age-matched control participants were asked to learn four new characters. The characters were learned under two different conditions, one without sonification and one with sonification, respecting a within-subject protocol. The results revealed that characters learned with sonification were reproduced more quickly and more fluently than characters learned without and that the effects of sonification were larger in deafferented than in control subjects. Secondly, whereas control subjects were able to learn the characters without sounds the deafferented subjects were able to learn them only when they were trained with sonification. Thirdly, although the
The increase in total integrated voltage of renal sympathetic nerve activity that occurs with peripheral thermal receptor stimulation (heat) decreases renal blood flow, and the renal vasoconstriction is prevented by prior renal denervation (34). As it was this stimulus that identified a unique subset of single renal sympathetic nerve fibers, we sought to determine quantitative aspects of the renal sympathetic neural discharge seen in multifiber recordings that were produced by peripheral thermal receptor stimulation. Postganglionic multifiber renal sympathetic nerve activity occurs in synchronized sympathetic discharges (bursts, peaks) with distinct coupling to the cardiac cycle. These synchronized renal sympathetic peaks may be characterized by their amplitude, duration, and frequency. Total integrated voltage encompasses the product of voltage under the curve of each peak (governed largely by peak amplitude as peak duration changes little) and peak frequency. Therefore, changes in total ...
Facet Denervation is available in Charlottesville VA. Facet Joints are the joints between the vertebrae in your spine that allow flexibility in the back.
my hotspot is my foot as well, well both feet really. They are twitching ALL THE TIME. Sorry to hear about your voice scare, its reassuring though that its gone back to normal. I have some bulbar concerns myself, as my tongue has lately been extremely sore, like I burned it on soup. This has made me very aware of my speech, Im feeling like Im stumbling over words, biting the tip of my tongue, and every now and then my voice breaks when I talk. Ive been told that this might be psychosomatic, from all that fear and worry im experiencing. I hope so , who knows... Im actually starting therapy next week (something I never thought I would do), but I think it will be good to not load this stuff on my family and friends so much anymore. I still worry about those EMG results and chronic denervation, even though docs told me they would see spontaneous activity if it were a motor neurone problem... But increasing symptoms just make me doubtful. Im sure you can relate, considering yours have been ...
The role of the sinoaortic reflexes in the regulation of ventilation during exercise was evaluated in seven awake dogs prepared with chronic tracheostomies and arterial catheters. Each dog ran on a treadmill at several work loads before and after sin
In a preliminary study using a mouse model, researchers found that vagal denervation using Botox or other methods could help slow gastric cancers growth.
Based on reports that S1P-receptor signaling is involved in neuronal plasticity (e.g., [34, 40, 41]), regulation of neurite remodeling (e.g., [40, 42]), and neuroprotection (e.g., [33, 43, 44]) and also because of the relevance of FTY720 in the treatment of MS, we wondered whether FTY720 could have an influence on denervation-induced dendritic changes. Indeed, FTY720 prevented the denervation-induced reduction in TDL. Furthermore, dynamic imaging revealed that FTY720 stabilizes denervated dendrites and thus prevents the denervation-induced change in the balance of dendritic retraction and elongation. This neuro-stabilization seems to be a direct effect of FTY720 on neural tissue, since the peripheral immune system, which is regarded as the main target of FTY720, is missing in organotypic slice culture preparations. To control for off-target effects of FTY720 (and its agonist-antagonist properties; [16-18]), we repeated these experiments with the S1PR1/3-inhibitor VPC23019 and obtained very ...
Tokyo ― Terumo Corporation (TSE: 4543 Section 1) announced CE marking for the commercial sale of the Iberis™ Renal Sympathetic Denervation System, which the company has consigned product development to Shanghai AngioCare Medical Technology Co., Ltd. (hereinafter AngioCare) (Representative: Philip Wang), a Chinese company in renal sympathetic denervation technology for resistant hypertension treatment.. In December, 2012, Terumo formed a strategic alliance with AngioCare. Furthermore, the company has consigned product development to AngioCare and acquired the exclusive distribution rights for its renal sympathetic denervation technology on the global market.. Sales of Iberis in Europe will be commenced with its launch at the worlds leading cardiovascular intervention course, EuroPCR to be held in France in May, 2013.. Terumo aims to expand its renal sympathetic denervation business by launching Iberis in Asian and Latin American countries where the CE marked product is allowed for ...
2016 Annual Meeting: Growth Hormone Ameliorates the Effects of Chronic Denervation Injury on Peripheral Nerve Regeneration and Improves Upper Extremity Murine Function
Objective: To determine the effect of renal denervation (RDN) on the severity of atherosclerosis and aortic aneurysm in hypertensive mice. Methods: Hypertension, atherosclerosis and aortic aneurysm were induced by subcutaneous infusion of angiotensin II (1 µg/kg/min) for 28 days in apolipoprotein E-deficient mice. RDN was conducted using combined surgical and local chemical denervation. The norepinephrine concentration in the kidney was measured by high-performance liquid chromatography. Blood pressure was measured by the tail-cuff method. Atherosclerosis was assessed by Sudan IV staining of the aortic arch. The aortic diameter was measured by the morphometric method. The mRNA expression of genes associated with atherosclerosis and aortic aneurysm were analyzed by quantitative PCR. Results: RDN decreased the median norepinephrine content in the kidney by 93.4% (n=5-7, P=0.003) five days after the procedure, indicating that the RDN procedure was successful. RDN decreased systolic blood pressure in
Renal sympathetic denervation (RSDN), or renal denervation (RDN), is a minimally invasive, endovascular catheter based procedure using radiofrequency ablation or ultrasound ablation aimed at treating resistant hypertension (high blood pressure not controlled by medication).
Author: Borroni, E. et al.; Genre: Journal Article; Published in Print: 1985-08; Title: The localization and rate of disappearance of a synaptic vesicle antigen following denervation.
Treatment of facet syndrome with radiofrequency denervation (costs for program #260607) ✔ Asklepios Academic City Hospital Bad Wildungen ✔ Department of Neurosurgery and Spine Surgery ✔ BookingHealth.com
Treatment of facet syndrome with radiofrequency denervation (costs for program #183895) ✔ St. Anna Hospital Herne ✔ Department of Orthopedics and Trauma Surgery ✔ BookingHealth.com
Radiofrequency denervation is a treatment for some kinds of lower back and neck pain. It uses an electrical current created by radio waves.
Find and book the best doctor specialised in radiofrequency denervation. Compare patient reviews, insurance, prices and get your referral letter instantly.
Costello, J.P., Wilson, J.K., Louis, C., Peer, S.M., Zurakowski, D. et al. (2015). Surgical cardiac denervation therapy for treatment of congenital ion channelopathies in pediatric patients: a contemporary, single institutional experience. World Journal of Pediatric and Congenital Heart Surgery, 6(1), 33-38.. ...
The effect of renal denervation on arterial stiffness, central blood pressure and heart rate variability in treatment resistant essential hypertension: a substudy of a randomized sham-controlled double-blinded trial (the ReSET trial). / Peters, Christian Daugaard; Mathiassen, Ole Norling; Vase, Henrik; Bech Nørgaard, Jesper; Christensen, Kent Lodberg; Schroeder, Anne Pauline; Rickers, Hans Joachim von Hofe; Opstrup, Ulla Kampmann; Poulsen, Per Løgstrup; Langfeldt, Sten; Andersen, Gratien; Hansen, Klavs Würgler; Bøtker, Hans Erik; Engholm, Morten; Bertelsen, Jannik Buus; Pedersen, Erling Bjerregaard; Kaltoft, Anne; Buus, Niels Henrik.. In: Blood Pressure, Vol. 26, No. 6, 2017, p. 366-380 .. Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review ...
This journal subscribes to the principles and guidelines of the Committee on Publication Ethics (COPE)www.publicationethics.org ...
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A. Jouvenceau, J.M. Billard, R. Wiley, Y. Lamour, P. Dutar. Cholinergic denervation of the rat hippocampus by 192-lgG-saporin. NeuroReport, Lippincott, Williams & Wilkins, 1994, 5 (14), pp.1781-1784. ⟨10.1097/00001756-199409080-00024⟩. ⟨hal-02325730⟩ ...
Rothman A, Jonas M, Castel D, Tzafriri AR, Traxler H, Shav D, Leon MB, Ben-Yehuda O, Rubin L. Pulmonary Artery Denervation Using Catheter based Ultrasonic
I would ask any potential person to ask many questions before having spermatic cord denervation. Especially regarding stats that make this look like a better treatment then is stated. Almost everyone will likely feel b…
Following kainate lesions of hippocampal subfield CA3, the remaining CA 1 pyramidal cells become hyperexcitable. This lesion is of interest because, morphologically, it resembles the damage often seen in cases of temporal lobe epilepsy; it may provide insight into the consequences of such cell loss in humans. The hyperexcitability in CA 1 is associated with a loss of both early and late IPSPs. At long postlesion latencies (2-4 months) inhibition shows partial recovery and the hyperexcitability subsides. The intent of the present work was to determine if alterations in CA 1 excitability and functional inhibition postlesion are correlated with changes in morphologic and physiologic indicators of inhibitory interneuron function or with alterations in binding sites for inhibitory transmitters. Using GAD immunocytochemistry, we found no acute or chronic lesion-induced decrease in numbers of CA 1 interneurons or in qualitative characteristics of the pericellular distribution of their terminals in CA 1 ...
The contribution of renal sympathetic nerve activity to the development and progression of resistant hypertension, has been convincingly demonstrated in both preclinical and human experiments....
MIAMI -- Renal denervation aimed at reducing refractory blood pressure provides some patients with an additional benefit -- a reduction in heart rate.
Renal denervation (RDN) represents a device-based hypertension treatment intended to lower sympathetic activity. Only a few years ago, RDN was written off as ineffective after results of the sham-controlled SYMPLICITY HTN-3 trial failed to confirm early trials reports of significant BP reductions in patients resistant to guideline- based combination drug therapy.
4) Denervation supersensitivity. Like any denervated muscle, the iris becomes supersensitive to its normal neurotransmitter (in ...
Denervation supersensitivityEdit. When the innervation to substance P nerve terminals is lost, post-synaptic cells compensate ... This, ultimately, leads to a condition known as denervation supersensitivity as the post-synaptic nerves will become ...
Ross AT (November 1958). "Progressive selective sudomotor denervation; a case with coexisting Adie's syndrome". Neurology. 8 ( ...
Denervation. When the afferent and efferent nerves are both destroyed, as they may be by tumors of the cauda equina or filum ... The hyperactive state in the former condition suggests the development of denervation hypersensitization even though the ...
Ramirez C, Donnellan N (2017). "Pelvic denervation procedures for dysmenorrhea". Curr Opin Obstet Gynecol. 29 (4): 225-230. doi ...
The onset of denervation supersensitivity. Langer SZ, Trendelenburg U. J Pharmacol Exp Ther. 1966 Jan;151(1):73-86 ... His research was on the mechanisms involving denervation supersensitivity. with Ullrich Trendelenburg with whom he became ... course of the development of supersensitivity to various amines in the nictitating membrane of the pithed cat after denervation ...
... "long-term denervation stage" of the rat model, i.e., denervation time longer than six months). In 3 out of 36 leg muscles, ... Chronaxie from 0.1-0.2 ms in innervated muscle changed to 0.5-1 ms within one to two days after denervation (i.e., after ... Chronaxie remained at this level up to 6 months postsciatectomy (Mid-term denervation stage in the rat model: from 2 to 6 ... Several studies have suggested that the function of denervation-induced myoD may be to prevent the muscle atrophy induced by ...
There is a lack of good quality evidence to support the use of radiofrequency denervation for pain relief. KT Tape has been ... Maas ET, Ostelo RW, Niemisto L, Jousimaa J, Hurri H, Malmivaara A, van Tulder MW (October 2015). "Radiofrequency denervation ...
Radiofrequency denervation may provide temporary relief for specific affected areas in the neck. Transcutaneous electrical ... Niemisto L, Kalso E, Malmivaara A, Seitsalo S, Hurri H (2003-01-20). "Radiofrequency denervation for neck and back pain. A ...
Denervation Neuroregeneration Targeted reinnervation The Williams Dictionary of Biomaterials. Liverpool University Press. 1999 ...
Needle electromyography studies generally reveal no signs of denervation. Megavitamin-B6 syndrome is characterized mainly by ...
Occasionally, biopsy of skin, nerve, or muscle may be performed, which can show signs of denervation and amyloid deposition ... may show evidence of chronic denervation and reinnervation. Autonomic testing, including quantitative sweat testing, can reveal ...
The affected pupil is thus miotic and the pupillary dilator responds to denervation by increasing α1 receptors. Apraclonidine ... Koc F, Kansu T, Kavuncu S, Firat E (2006). "Topical apraclonidine testing discloses pupillary sympathetic denervation in ...
Chao CC, Sun HY, Chang YC, Hsieh ST (January 2008). "Painful neuropathy with skin denervation after prolonged use of linezolid ...
The future may hold non-pharmacologic solutions such as renal sympathetic denervation. Perkes, Iain; Baguley, Ian J.; Nott, ... 13 (370). doi:10.1007/s11910-013-0370-3. Renal Sympathetic Denervation, From Wikipedia, the free encyclopedia12/7/2014. ...
Goebel, F.-D.; Füessl, H.S. (1983). "Mönckeberg's sclerosis after sympathetic denervation in diabetic and non-diabetic subjects ... He has documented loss of thermoregulatory function, cardiac denervation, and loss of vasoconstriction. Recurrence of the ... Because of these difficulties, and because of disabling sequelae associated with sympathetic denervation, conventional or "open ... "Partial cardiac sympathetic denervation after bilateral thoracic sympathectomy in humans". Heart Rhythm. 2 (6): 602-9. doi: ...
Other treatments may include denervation, autotransplantation, renal neurectomy, or nephrectomy. Unfortunately symptoms often ... Pruritus management Maintenance therapy between pain exacerbations Implantable drug delivery system Surgical renal denervation ...
It is true that all inflammatory and non-inflammatory heart disease may display forms of parasympathetic denervation; this ... denervation presents in a descriptive fashion in Chagas' disease. It has also been indicated that the loss of parasympathetic ...
This finding was shown to be absent in healthy subjects, and may be the cause of denervation-related atrophy of the external ... There may be denervation of striated musculature on the electromyogram. Increased nerve conduction periods (nerve damage), this ... This is most likely a denervation injury to the external anal sphincter. The assumed mechanism of fecal incontinence in rectal ...
Denervation. When the afferent and efferent nerves are both destroyed, as they may be by tumors of the cauda equina or filum ... The hyperactive state in the former condition suggests the development of denervation hypersensitization even though the ...
Additional electromyography is helpful to reveal any decelerated nerve conduction velocity, and thus denervation of the ... September 2006). ". Ultrasound findings of teres minor denervation in suspected quadrilateral space syndrome". J Clin ...
Therefore, the diabetic heart shows clear denervation as the pathology progresses. This denervation correlates with ... Other causes of denervation are ischemia from microvascular disease and thus appear following the development of ...
... a novel neurite-outgrowth factor secreted by muscle after denervation". NeuroReport. 8 (16): 3649-3654. doi:10.1097/00001756- ...
... is a rotator cuff denervation syndrome in which the axillary nerve is compressed at the ... Differential considerations include similar rotator cuff denervation syndromes such as Parsonage-Turner syndrome, and ... "Ultrasound findings of teres minor denervation in suspected quadrilateral space syndrome". Journal of Clinical Ultrasound. 34 ( ...
Schwartz PJ, De Ferrari GM, Pugliese L (June 2017). "Cardiac sympathetic denervation 100years later: Jonnesco would have never ... or with surgical procedures including sympathetic denervation and implantation of a defibrillator. It is thought to affect as ... region of the sympathetic nervous system can be intentionally damaged in an operation known as cardiac sympathetic denervation ...
Garcia A, Fulton JE (1996). "Cosmetic denervation of the muscles of facial expression with botulinum toxin. A dose-response ...
Denervation increases a neurite-promoting activity in extracts of skeletal muscle. Nature. 1983 Apr 14;302(5909):609-11. Betz H ... During the 1970s, he tried to document this phenomenon, either by studying mutant animals or by experimental denervation. While ...
... pilocarpine may constrict the tonic pupil due to cholinergic denervation supersensitivity. A normal pupil will not constrict ... "Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie's Syndrome". Case Reports in Neurological Medicine ...
"The skin projection point of the neurovascular bundle (NVB) represents the denervation point (DP)." The NVB (thoracoacromial ... Titiz, Izzet; Ozel; Ozel; Toros; Marur; Yildirim; Erdogdu; Kara (19 August 2010). "Denervation Point for Neuromuscular Blockade ... may be the guide for local anesthetic applications in order to achieve pectoral muscle denervation. "Routine botulinum toxin ...
July 2006). "Impact of liver transplantation on cardiac autonomic denervation in familial amyloid polyneuropathy". Medicine ( ...
Denervation is any loss of nerve supply regardless of the cause. If the nerves lost to denervation are part of the neuronal ... Denervation may be the result of nerve injury. The three main types of nerve injury are neurapraxia, axonotmesis and ... Denervation can have many harmful side effects such as increased risk of infection and tissue dysfunction.[2] ... This process of denervation is however different from post-polio syndrome in that it only involves upper and lower motor neuron ...
Can renal denervation get you off medication? The studies so far have demonstrated blood pressure lowering in 90 percent or ... If your blood pressure is normal but you are on many medications, could renal denervation enable you to reduce or eliminate ... called renal denervation, involves interrupting nerves of the sympathetic nervous system that connect the brain and the kidneys ...
... Learn more about the Massachusetts General Hospital Division of Plastic and ... In order to determine if a patient is a good candidate for joint denervation surgery, local anesthetic is injected into the ... These procedures, known as joint denervations, are short in duration and can often be performed without general anesthesia. ... Patients undergoing a joint denervation procedure will have incisions placed at the locations of the different nerves supplying ...
Denervation provided significant blood-pressure reductions for patients with stage 2 hypertension compared with a sham control ... Key to Denervation Response for Hypertension May Be in Carotid Body * FDA Promises Rigorous Review of New Renal Denervation ... Office readings showed SBP fell 10.0 mm Hg with denervation (P,0.001) and 2.3 mm Hg with sham (P=0.24), while DBP declined 5.3 ... Finally, drug testing of serum and urine confirmed that 94.3% of patients in the renal-denervation group and 92.7% in the sham ...
Denervation supersensitivity/Denervation hypersensitivity is the sharp increase of sensitivity of post-synaptic membranes to a ... S. Thesleff, L.C. Sellin, "Denervation supersensitivity", Trends in Neurosciences, Volume 3, Issue 5, May 1980, Pages 122-126 ... doi:10.1016/0166-2236(80)90046-6 S. Z. Langer, "Denervation Supersensitivity", in: Principles of Receptor Research Volume 2 of ... chemical transmitter after denervation. It is a compensatory change. ...
A new meta-analysis of six sham-controlled studies of renal sympathetic denervation has shown a significant reduction in blood ... "This led to a loss of interest in the approach, but many of us held out hope that denervation could still be effective," he ... "After the SYMPLICITY HTN-3 trial, which failed to show a benefit of denervation, there was a loss of hope in this approach, but ... "This meta-analysis as a whole has shown a significant benefit of denervation over sham control, but when we looked at the more ...
Find the most comprehensive real-world symptom and treatment data on denervation at PatientsLikeMe. 2 patients with denervation ... and insomnia and use Gabapentin and Oxycodone-acetaminophen to treat their denervation and its symptoms. ... What is denervation?. Denervation refers to loss of nerve supply. It may be caused by a disease, injury, or intentional ... 0 evaluations from denervation patients report that they could not tell effectiveness of Oxycodone-acetaminophen for pain (0%) ...
Cord denervation: Surgeons describe microsurgical techniques in men with scrotal pain. July 31, 2017 ...
These research discoveries led to the development of a catheter-based procedure for renal denervation in human subjects. A ... Translational medicine: the antihypertensive effect of renal denervation.. DiBona GF1, Esler M. ... with hypertension resistant to conventional therapy has demonstrated that the procedure is safe and produces renal denervation ...
Renal denervation reduces recurrent atrial fibrillation (AF) when performed with pulmonary vein isolation ablation in patients ... Renal denervation reduces recurrent AF after ablation. European Society of Cardiology. Journal. European Heart Journal. Meeting ... Renal sympathetic denervation (RD) is a new method that may be effective for controlling resistant hypertension by reducing the ... Renal sympathetic denervation was considered to have been achieved when the sudden increase of blood pressure (>15 mmHg from ...
A major trial of Medtronics renal denervation system failed to meet its primary efficacy endpoint in a population of patients ... Jude Medicals renal denervation system -- EnligHTN-IV -- was stopped after enrolling fewer than 10 patients because of ... "I do not think this is the end of renal denervation," commented another study investigator Cindy Grines, MD, of Detroit Medical ... There is ample data that renal denervation reduces blood pressure in animal models and in smaller human trials, and there are ...
... renal sympathetic denervation did not achieve a benefit in patients with mild but treatment-resistant hyperte ... TCT: Renal Denervation No Better Than Sham. by Peggy Peck, Editor-in-Chief, MedPage Today September 16, 2014 ... Source Reference: Desch, S et al "A randomized sham-controlled trial of renal sympathetic denervation in mild resistant ... WASHINGTON -- In a small study using ambulatory systolic pressure readings as an endpoint, renal sympathetic denervation (RSD) ...
... as it will unveil its new OneShot renal denervation system at the ... latest in a line of companies entering the renal denervation ... Covidien Introduces OneShot Renal Denervation System. May 8th, 2012 Wouter Stomp Medicine, Radiology, Vascular Surgery ... Covidien is the latest in a line of companies entering the renal denervation business, as it will unveil its new OneShot renal ... If you are attending EuroPCR, it will be possible to watch two denervation procedures that will be transmitted live from ...
Experimental: Denervation + TMNS Patients are treated with the renal denervation procedure after randomization and are ... Procedure: Percutaneous renal denervation and TMNS Patients are treated with the renal denervation procedure after ... Renal Denervation in Diabetic Nephropathy (DERENEDIAB). The safety and scientific validity of this study is the responsibility ... Persu A, Sapoval M, Azizi M, Monge M, Danse E, Hammer F, Renkin J. Renal artery stenosis following renal denervation: a matter ...
Local Sympathetic Denervation in Painful Diabetic Neuropathy. Cees J. Tack, Petra J. van Gurp, Courtney Holmes, David S. ... Local Sympathetic Denervation in Painful Diabetic Neuropathy. Cees J. Tack, Petra J. van Gurp, Courtney Holmes, David S. ... Local Sympathetic Denervation in Painful Diabetic Neuropathy Message Subject (Your Name) has forwarded a page to you from ...
Catheter-based renal denervation for resistant hypertension: 12-month results of the EnligHTN I first-in-human study using a ... Bilateral Renal Artery Stenosis After Renal Denervation. Fernando Jaén Águila, Juan Diego Mediavilla García, Eduardo Molina ... Renal artery stenosis, after renal denervation, with spontaneous resolution two year follow-up from procedure. Fernando Jaen ... Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3- year report of the Symplicity HTN-1 ...
Catheter-Based Renal Denervation for Resistant Hypertension. Vasilios Papademetriou, Costas P. Tsioufis, Ajay Sinhal, Derek P. ... Catheter-Based Renal Denervation for Resistant Hypertension. Vasilios Papademetriou, Costas P. Tsioufis, Ajay Sinhal, Derek P. ... Catheter-Based Renal Denervation for Resistant Hypertension. 12-Month Results of the EnligHTN I First-in-Human Study Using a ... Renal denervation has emerged as a novel approach for the treatment of patients with drug-resistant hypertension. To date, only ...
Renal denervation Renal denervation using Symplicity Catheter system. Device: Renal denervation using Symplicity Catheter ... Renal Denervation in Treatment Resistant Hypertension. The safety and scientific validity of this study is the responsibility ... Impact of renal denervation on tissue Na(+) content in treatment-resistant hypertension. Clin Res Cardiol. 2018 Jan;107(1):42- ... Renal denervation in moderate treatment-resistant hypertension. J Am Coll Cardiol. 2013 Nov 12;62(20):1880-6. doi: 10.1016/j. ...
... million by 2022, Rising at a Market Growth of 48.5% CAGR During the ... Key findings from the Renal Denervation Market:. • Based on product type, Symplicity Renal Denervation System sector is the ... The Vessix Renal Denervation System is expected to grow at its fastest rate, with an average annual growth rate of 57.6% from ... Renal Denervation Market Size Is Expected To Reach $ 3,153 million by 2022, Rising at a Market Growth of 48.5% CAGR During the ...
Holdings is set to acquire ReCor Medical for an undisclosed sum and follows Medtronic in a bid to get a renal denervation ... Otsuka Finds Paradise in Renal Denervation Market. Otsuka Holdings is set to acquire ReCor Medical for an undisclosed sum and ... Renal Denervation to treat hypertension has been somewhat elusive for medtech companies. While there was at one-point ... Any doubts about medtechs interest in renal denervation can now be put to rest. Otsuka Holdings is showing its very interested ...
Denervation suppresses gastric tumorigenesis. By Chun-Mei Zhao, Yoku Hayakawa, Yosuke Kodama, Sureshkumar Muthupalani, ... Denervation suppresses gastric tumorigenesis. By Chun-Mei Zhao, Yoku Hayakawa, Yosuke Kodama, Sureshkumar Muthupalani, ... Denervation suppresses gastric tumorigenesis Message Subject. (Your Name) has forwarded a page to you from Science ...
Home , Covidien to Exit OneShot Renal Denervation Program. Covidien to Exit OneShot Renal Denervation Program. Covidien [1] plc ... Covidien plc has announced it will exit its OneShot Renal Denervation program. This voluntary action is primarily in response ... Over the next several weeks, the company will collaborate with physicians and the renal denervation community to ensure ... This voluntary action is primarily in response to slower than expected development of the renal denervation market. ...
7. Bhatt DL, Kandzari DE, ONeill WW, DAgostino R, Flack JM, Katzen BT, et al A controlled trial of renal denervation for ... 4. Symplicity HTNI, Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, et al Renal sympathetic denervation in patients ... Spironolactone versus renal nerve denervation for treatment of uncontrolled resistant hypertension Journal of Hypertension34(9 ... Spironolactone versus sympathetic renal denervation to treat true resistant hypertension: results from the DENERVHTA study - a ...
Just two days after we reported on the design story behind the Vessix V2 renal denervation system,Vessix Vascular is now ... Vessix V2 Renal Denervation System Receives CE Mark Approval. May 2nd, 2012 Wouter Stomp Cardiology, Medicine, Radiology, ... Just two days after we reported on the design story behind the Vessix V2 renal denervation system,Vessix Vascular is now ... According to the company, the system is faster, easier to use and less painful for patients than any renal denervation system ...
Renal Denervation After Ablation Reduces Recurrent AF. Recurrent atrial fibrillation is reduced when renal denervation is ... In Advanced Heart Failure Renal Denervation Gives Better Outcomes Than Drugs According to research, renal denervation leads to ... The key implication of this study is that "renal denervation does lower arterial pressure when the denervation is complete," ... Confounding Factors Which Lead to Unexpected Results of Renal Denervation Trial. Analysis of renal denervation trial, ...
... but results from both studies linked renal denervation with significant reductions in BP on several assessments ... Two sham-controlled trials demonstrating the efficacy of renal denervation presented at EuroPCR have rekindled hope for the ... in that performing renal denervation with different intravascular techniques yields the same results. Renal denervation ... were randomly assigned to renal denervation with the Symplicity Spyral multielectrode renal denervation catheter (Medtronic) ...
RF denervation used for disc pain produces conflicting results, with no effects for RF denervation compared with placebo over ... Radiofrequency denervation for chronic low back pain. Background Low back pain is a widespread problem that has major social ... When RF denervation is used for SI joint pain, low-quality evidence reveals no differences from placebo in effects on pain (MD ... Radiofrequency (RF) denervation, an invasive treatment for chronic low back pain (CLBP), is used most often for pain suspected ...
Conclusion: Video-assisted CSD should be considered as a treatment option for patients with potentially dangerous arrhythmias that do not respond to conventional treatment, especially in recurrent ventricular tachycardia. PMID: 31588139 [PubMed - in process]...
Renal denervation (RDN) represents a device-based hypertension treatment intended to lower sympathetic activity. Only a few ... PCR State-of-the-art lecture on The resurgence of renal denervation Renal denervation significantly reduces blood pressure, ... A PCR State-of-the-Art lecture on "The resurgence of renal denervation" by Felix Mahfoud o Presentation during the #PCR e- ... Renal denervation (RDN) represents a device-based hypertension treatment intended to lower sympathetic activity. Only a few ...
  • In renal denervation, the procedure involves using radio frequency or ultrasound to remove sympathetic nerve supply to the wall of the kidney with the intention of reducing blood pressure and treating chronic hypertension . (wikipedia.org)
  • An exciting and promising new procedure, which can help lower blood pressure in patients with resistant hypertension (hypertension not controlled by medication), is currently under study in 90 medical centers, including ours, throughout the U.S. The procedure, called renal denervation, involves interrupting nerves of the sympathetic nervous system that connect the brain and the kidneys as they course through the renal arteries (the arteries to the kidneys). (huffingtonpost.com)
  • In SIMPLICITY HTN-3, patients had resistant hypertension (office SBP 180 mm Hg, with no diastolic cutoff), self-reported drug adherence to 5.1 medications prescribed at randomization, and received denervation of the main renal artery only performed by mostly inexperienced operators using a monoelectrode, sequential ablation system, Böhm said. (medscape.com)
  • In contrast, SPYRAL HTN-OFF MED enrolled patients with an office SBP of 150 to less than 180 mm Hg, an office DBP of at least 90 mm Hg, and a mean 24-hour ambulatory SBP of 140 to less than 170 mm Hg and excluded those with isolated systolic hypertension because they've been shown to be hyporesponsive to renal denervation. (medscape.com)
  • Invited discussant Prof Bryan William (University College London, UK) agreed that the data provide proof of concept that renal denervation lowered blood pressure in "about 75% of patients studied" but said by excluding those with isolated systolic hypertension it missed "the most common and most difficult-to-treat hypertension phenotype. (medscape.com)
  • combined hypertension seems to respond better to denervation than isolated systolic hypertension. (medscape.com)
  • These include minimization of participants with isolated systolic hypertension, performance of procedures by highly experienced operators, employment of more complete techniques of radiofrequency ablation, and use of other novel approaches such as endovascular ultrasound renal denervation. (medscape.com)
  • A proof-of-principle study in patients with hypertension resistant to conventional therapy has demonstrated that the procedure is safe and produces renal denervation with sustained lowering of arterial pressure. (nih.gov)
  • Barcelona, Spain - Sunday 31 August 2014: Renal denervation reduces recurrent atrial fibrillation (AF) when performed with pulmonary vein isolation ablation in patients with AF and hypertension, according to research presented at ESC Congress today by Dr Alexander Romanov from the Russian Federation. (eurekalert.org)
  • Renal sympathetic denervation (RD) is a new method that may be effective for controlling resistant hypertension by reducing the hyperactivity of the renal sympathetic nerve. (eurekalert.org)
  • A major trial of Medtronic's renal denervation system failed to meet its primary efficacy endpoint in a population of patients with treatment-resistant hypertension, the company said Thursday. (medpagetoday.com)
  • WASHINGTON -- In a small study using ambulatory systolic pressure readings as an endpoint, renal sympathetic denervation (RSD) did not achieve a benefit in patients with mild but treatment-resistant hypertension. (medpagetoday.com)
  • Desch, S et al "A randomized sham-controlled trial of renal sympathetic denervation in mild resistant hypertension" TCT 2014. (medpagetoday.com)
  • Like all other recently introduced denervation systems, it is intended to treat patients with hypertension who are not responsive to traditional medical therapy. (medgadget.com)
  • Renal stenosis after sympathetic denervation of the renal arteries in hypertensive patients is a very unusual complication, but it sometimes appears together with hypertension recurrence. (ahajournals.org)
  • Renal denervation has emerged as a novel approach for the treatment of patients with drug-resistant hypertension. (ahajournals.org)
  • Tokyo-based Otsuka's big play comes just a few short days after MD+DI reported that FDA gave Palo Alto, CA-based ReCor Medical the green light to run a pivotal study of its ultrasound-based renal denervation system for the treatment of hypertension. (mddionline.com)
  • Renal Denervation to treat hypertension has been somewhat elusive for medtech companies. (mddionline.com)
  • Just two days after we reported on the design story behind the Vessix V2 renal denervation system, Vessix Vascular is now announcing it has received European CE Mark approval for its percutaneous radiofrequency balloon catheter technology for the treatment of hypertension. (medgadget.com)
  • Now, researchers report in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology that renal denervation-a procedure that disrupts the nerves in the kidneys and prevents them from relaying signals-can treat hypertension, including resistant hypertension, when the nerves are completely blocked. (medindia.net)
  • Renal denervation lowers blood pressure when performed at either the early or late stages of hypertension. (medindia.net)
  • Recurrent atrial fibrillation is reduced when renal denervation is performed with pulmonary vein isolation ablation in patients with AF and hypertension, suggests a research. (medindia.net)
  • Reducing blood pressure in patients with resistant hypertension using renal denervation seems to be more successful when it includes accessory renal arteries, suggests a study. (medindia.net)
  • Two sham-controlled trials demonstrating the efficacy of renal denervation presented at EuroPCR have rekindled hope for the technology as a treatment for hypertension. (healio.com)
  • Renal denervation as a treatment for resistant hypertension experienced a setback in 2014 with the failure of the SYMPLICITY-HTN 3 trial . (healio.com)
  • In the SPYRAL HTN-ON MED trial, researchers sought to evaluate the effect of renal denervation therapy on BP in the presence of commonly prescribed antihypertensive medications "in a context considered more representative of clinical practice - integrating both device therapies and pharmacotherapies for the treatment of uncontrolled hypertension," David E. Kandzari, MD, from the Piedmont Heart Institute in Atlanta, said. (healio.com)
  • These patients with uncontrolled hypertension, defined as systolic BP between 150 mm Hg and 180 mm Hg while taking one to three antihypertensive medications, were randomly assigned to renal denervation with the Symplicity Spyral multielectrode renal denervation catheter (Medtronic) and the Symplicity G3 renal denervation RF generator (Medtronic) or sham procedure consisting of a renal angiogram. (healio.com)
  • Renal denervation (RDN) represents a device-based hypertension treatment intended to lower sympathetic activity. (eurekalert.org)
  • The study is intended to evaluate safety and efficacy of multi-electrode radiofrequency renal denervation in patients with uncontrolled hypertension. (clinicaltrials.gov)
  • We are now looking back on 10 years of experience with catheter-based renal sympathetic denervation for treatment of human hypertension and it has been a long and winding road. (lww.com)
  • Renal denervation (RDN), as a treatment for hypertension, initially gained traction early this century. (bmj.com)
  • 4578 ) said today that it plans to acquire the remaining stake it doesn't already own in ReCor Medical and the renal denervation device it's developing to treat hypertension. (massdevice.com)
  • ReCor's statistically significant clinical results in the Solo trial are convincing biological proof that renal denervation with ReCor's ultrasound-based system is effective in reducing blood pressure in patients with hypertension. (massdevice.com)
  • We are excited to commercialize this technology, which has the potential to become one of the great technological advancements in hypertension treatment together with the ReCor team," Kazumichi Kobayashi, global renal denervation project leader, said in a press release. (massdevice.com)
  • When medication fails and patients appear to suffer from drug resistant hypertension, a renal sympathetic denervation is a possible treatment. (rug.nl)
  • Renal artery denervation is a new minimally invasive radiological procedure for the treatment of hypertension (high blood pressure) which is resistant to combination drug therapy. (bmihealthcare.co.uk)
  • Renal denervation has been developed in order to lower systolic blood pressure in resistant hypertension by a reduction in renal afferent and efferent sympathetic nerve activity. (ovid.com)
  • An international, multi-center, prospective, randomized, controlled study of the safety and effectiveness of renal denervation in patients with uncontrolled hypertension. (clinicaltrials.gov)
  • Cochrane corner: renal denervation for resistant hypertension-a broken promise? (bmj.com)
  • Here we report on the effects of renal denervation on hemodynamic, metabolic, and renal parameters in two obese PCOS patients with hypertension. (nih.gov)
  • This book examines renal pathophysiology and the rationale for renal denervation (RDN), a minimally invasive, endovascular catheter based procedure using radiofrequency ablation for the treatment of resistant hypertension, a leading cause of morbidity and mortality in western civilization. (springer.com)
  • 1.1 Current evidence on percutaneous transluminal radiofrequency sympathetic denervation of the renal artery for resistant hypertension is from limited numbers of patients, but there is evidence of efficacy in the short and medium term. (nice.org.uk)
  • 1.2 Clinicians wishing to undertake percutaneous transluminal radiofrequency sympathetic denervation of the renal artery for resistant hypertension should take the following actions. (nice.org.uk)
  • While electrical stimulation of baroreceptors and other interventional treatments of hypertension are already "knocking at the door", the premature and uncontrolled dissemination of renal denervation should remain an example of what should not be done, and trigger radical changes in evaluation processes of new devices by national and European health authorities. (springer.com)
  • In 2009, Krum and colleagues [ 1 ] published a non-randomised proof-of-concept study, testing percutaneous radiofrequency catheter-based renal sympathetic denervation (RDN) as a novel treatment of resistant hypertension in a cohort of 45 patients. (springer.com)
  • There is convincing evidence from studies like the Enlightn I trial linking renal denervation to improved blood pressure in patients who have drug-resistant hypertension,' principal investigator Dr. Johannes Brachmann said in prepared remarks. (massdevice.com)
  • In May 2012 St. Jude landed CE Mark approval and announced commercial launch for its Enlightn renal denervation system as a treatment for hypertension. (massdevice.com)
  • Renal artery denervation for patients with uncontrolled hypertension in the absence of renal artery stenosis. (oncologynurseadvisor.com)
  • Renal artery denervation is typically contraindicated in patients with renal artery abnormalities, such as renal artery stenosis, or any known secondary cause of hypertension including a glomerular filtration rate of 45 mL/min. (oncologynurseadvisor.com)
  • Sympathetic denervation of the renal artery is considered if hypertension fails to respond adequately to these measures. (nice.org.uk)
  • An example of criteria used to select patients for the procedure is given in the Joint UK Societies' Consensus Statement on Renal Denervation for Resistant Hypertension. (nice.org.uk)
  • 2.2.1 Percutaneous transluminal radiofrequency sympathetic denervation of the renal artery for resistant hypertension aims to disrupt neurogenic reflexes involved in blood pressure control. (nice.org.uk)
  • Growing incidences of hypertension, changing lifestyle, and enduring effect of renal denervation procedure are the key factors driving market.Increasing cases of uncontrolled and drug-resistant hypertension are expected to fuel the demand for renal denervation. (medindia.net)
  • Furthermore, hypertension is responsible for at least 51% of deaths due to stroke and 45% of deaths due to heart disease.The renal denervation market in developed economies, such as U.K., France , and Italy , is comparatively mature owing to the presence of key companies in these countries and high demand for such products. (medindia.net)
  • Renal denervation fell short of primary and secondary efficacy goals in patients with severe resistant hypertension but did meet the primary safety endpoints, according to keenly awaited data from SYMPLICITY HTN-3 presented at the American College of Cardiology's 63rd Annual Scientific Session. (medicalxpress.com)
  • This pivotal trial is the largest study conducted of renal artery denervation as a treatment for resistant hypertension and the most rigorously designed, including blinding and a sham treatment in the control arm. (medicalxpress.com)
  • Although renal denervation is in clinical use for uncontrolled hypertension in more than 80 countries, it is still considered an experimental approach in the United States. (medicalxpress.com)
  • This study randomly assigned 535 patients with resistant hypertension and systolic blood pressure of 160 mmHg or higher to renal denervation or angiography alone. (medicalxpress.com)
  • We saw no added treatment benefit of renal denervation for patients with severe resistant hypertension who were closely monitored and optimally treated with medications. (medicalxpress.com)
  • Renal Denervation (RDN) also known as Renal Sympathetic Denervation (RNSD) is a minimally invasive, catheter-based endovascular procedure that utilizes radiofrequency energy or ultrasound energy to ablate nerves in the walls of the renal artery, causing a reduction in blood pressure in patients with resistant hypertension. (reportbuyer.com)
  • HealthDay News) - For patients with treatment-resistant hypertension and chronic kidney disease, renal denervation (RDN) reduces blood pressure (BP) and can slow renal function decline, according to a study presented at the American Heart Association's 2013 Scientific Sessions, held from Nov. 16-19 in Dallas. (empr.com)
  • Sympathetic denervation and neuromodulation techniques still provide an exciting opportunity for the treatment of resistant hypertension and of a variety of other diseases. (businesswire.com)
  • LEXINGTON, Mass.--( BUSINESS WIRE )--Though a large body of scientific research has convincingly demonstrated the link between sympathetic activity and drug-resistant hypertension, catheter-based renal denervation has been confounded by unreliable efficacy in large patient populations. (businesswire.com)
  • Tokyo ― Terumo Corporation (TSE: 4543 Section 1) announced CE marking for the commercial sale of the Iberis™ Renal Sympathetic Denervation System, which the company has consigned product development to Shanghai AngioCare Medical Technology Co., Ltd. (hereinafter 'AngioCare') (Representative: Philip Wang), a Chinese company in renal sympathetic denervation technology for resistant hypertension treatment. (terumo-europe.com)
  • EMAILWIRE.COM , January 11, 2017 ) Renal denervation is a catheter-based minimally-invasive ablation procedure that helps reduce systolic blood pressure in individuals with drug-resistant hypertension. (emailwire.com)
  • As a result, interest in renal denervation as a treatment for resistant hypertension has waned. (bmj.com)
  • In the DENERHTN trial, Azizi and colleagues assessed the incremental benefit of adding renal denervation to standardized stepped-care antihypertensive treatment (SSAHT) for patients with resistant hypertension in an open-label, randomized-controlled trial with blinded endpoint evaluation. (bmj.com)
  • After four weeks of a standardized anti-hypertensive regimen to confirm resistant hypertension, patients were randomized to renal denervation in addition to SSAHT versus SSAHT alone. (bmj.com)
  • When added to a stepped antihypertensive treatment strategy, renal denervation led to a greater decrease in ambulatory blood pressure for patients with resistant hypertension than medications alone. (bmj.com)
  • These findings may reinvigorate interest in renal denervation and point to the need for additional trials to fully inform the role of this procedure in hypertension care. (bmj.com)
  • Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (denerhtn): A multicentre, open-label, randomised controlled trial. (bmj.com)
  • Therefore, renal denervation never became an accepted method of treating hypertension. (managedcaremag.com)
  • The Joint UK Societies' consensus statement on renal denervation for resistant hypertension is now published on line (link below). (renal.org)
  • Essentially it says that although the Joint UK Societies' group recognises that there were a number of flaws in the design and conduct of the Symplicity HTN-3 study, it does not recommend the use of renal denervation for treatment of resistant hypertension in routine clinical practice. (renal.org)
  • The radical sympathectomy and percutaneous catheter-based renal denervation (RDN) are two techniques proposed to treat life-threatening resistant hypertension. (embs.org)
  • The REQUIRE STUDY is a multi-center, randomized, double-blind, sham-controlled study, which aims to confirm the efficacy and safety of PRDS-001 (ReCor Medical Inc. Paradise in Europe) for renal denervation therapy in patients with treatment resistance hypertension, in comparison with the sham procedure. (centerwatch.com)
  • As many patients with uncontrolled hypertension struggle to adhere to lifelong drug therapy for a variety of reasons and may look to other options that complement traditional treatments, we believe this advance could help clinicians work with patients to better manage their high blood pressure," said Dave Moeller, vice president and general manager of the Coronary and Renal Denervation business, which is part of the Cardiac and Vascular Group at Medtronic. (globenewswire.com)
  • Medtronic is committed to the field of renal denervation and in addressing the unmet need in hypertension management globally, and we look forward to seeing more insights from our industry-leading SPYRAL HTN clinical program as we realize the full potential of the therapy. (globenewswire.com)
  • Among patients with resistant hypertension, it is very important to select patients most likely to benefit from renal sympathetic denervation, because they represent a very mixed group of diagnoses. (signavitae.com)
  • Renal sympathetic denervation has been demonstrated as an antihypertensive treatment in resistant hypertension patients with additional positive effects on glucose metabolism and insulin sensitivity in type 2 diabetes. (signavitae.com)
  • We report a single centre report of renal sympathetic denervation effects in a small cohort of patients with resistant hypertension and stage 2-3 chronic kidney disease. (signavitae.com)
  • Renal sympathetic denervation (RDN) has been demonstrated as an antihypertensive treatment in resistant hypertension patients, and triggers additional positive effects on glucose metabolism and insulin sensitivity in type 2 diabetes. (signavitae.com)
  • SAN FRANCISCO-The verdict is in for renal denervation for treatment-resistant hypertension: According to results from major trials at TCT, the therapy produces safe, efficient, and persistent reductions in blood pressure. (acc.org)
  • While the evidence gap on renal denervation for treatment-resistant hypertension is closing, the scope of possibilities for treating other conditions is growing. (acc.org)
  • According to Justin E. Davies, MBBS, PhD, early experience in small trials has shown that renal denervation improves cardiac function in patients with resistant hypertension, without introducing new safety events. (acc.org)
  • Despite meeting primary safety endpoints, SYMPLICITY HTN-3 - the pivotal U.S. trial examining renal denervation for treatment-resistant hypertension - has fallen short of its secondary efficacy goals, and failed to reach its primary efficacy endpoint as announced earlier this year by the study's sponsor. (acc.org)
  • The largest study of its kind, and the most rigorously designed - including blinding and a sham treatment in the control arm - SYMPLICITY HTN-3 sought to evaluate the safety and effectiveness of renal denervation with the investigational Symplicity renal denervation system in patients with treatment-resistant hypertension and systolic blood pressure higher than 160 mmHg. (acc.org)
  • to confirm previously reported benefits of renal denervation in patients with resistant hypertension. (acc.org)
  • Should this statement indeed hold true, we will have to come to grips with two facts: the SYMPLICITY studies merely document the natural history of resistant hypertension in clinical trials, and the time has come to turn the page on renal denervation for hypertension but by all means, let's not close the book. (acc.org)
  • Ocular sympathetic denervation associated with ocular hypertension: a case report. (bmj.com)
  • A case of ocular sympathetic denervation associated with ocular hypertension is reported. (bmj.com)
  • Following the spectacular crash and burn of the SYMPLICITY HTN-3 trial at the American College of Cardiology (ACC) meeting two weeks ago, the future of renal denervation (RDN) - the once highly promising catheter technology that many thought would cure resistant hypertension - appears in doubt. (jwatch.org)
  • Negative Findings on Renal Denervation for Hypertension: Sweet SYMPLICITY? (jwatch.org)
  • This week's topics include hospital variation in noninvasive cardiac imaging, percutaneous renal denervation in patients with treatment-resistant hypertension, and more. (jwatch.org)
  • Parasympathetic denervation hypersensitivity of the iris in ocular hypertension. (arvojournals.org)
  • Renal denervation was not superior to intensified medical treatment in patients with validated true resistant hypertension, in the 12-month results from the PRAGUE-15 trial. (eshonline.org)
  • However, these results do not support renal denervation as being more effective than intensified medical treatment with spironolactone for the treatment of true resistant hypertension. (eshonline.org)
  • In addition to peripheral nerve injury , denervation is used as a medical procedure for various benefits resulting from eliminating nerve supply to a specific area of the body. (wikipedia.org)
  • [6] However, renal denervation is used less frequently in recent years due to new evidence suggesting that blood pressure is not significantly reduced after the procedure and there are even recommendations against using the procedure since there has been little proof to show that renal denervation leads to reduced blood pressure. (wikipedia.org)
  • In order to determine if a patient is a good candidate for joint denervation surgery, local anesthetic is injected into the nerves supplying sensation to the painful joint (a procedure called a nerve block). (massgeneral.org)
  • Patients undergoing a joint denervation procedure will have incisions placed at the locations of the different nerves supplying their painful joint. (massgeneral.org)
  • These research discoveries led to the development of a catheter-based procedure for renal denervation in human subjects. (nih.gov)
  • Although the company didn't release specific numbers from the pivotal SYMPLICITY HTN-3 trial, the announcement bears out suggestions that renal denervation was turning out to be no better than a sham procedure at lowering office systolic blood pressure among patients who continued taking their anti-hypertensives over a 6-month period. (medpagetoday.com)
  • Renal artery stenosis, after renal denervation, with spontaneous resolution two year follow-up from procedure. (ahajournals.org)
  • While there was at one-point heightened interest in the procedure, medtech firms abandoned the field when Medtronic revealed disappointing results in its renal denervation trial in January of 2014. (mddionline.com)
  • Rapid RF treatment time greatly increases the efficiency of the denervation procedure and additional safety benefits to the clinician conducting the procedure and the patient in terms of less use of contrast dye and lower exposure to radiation. (medgadget.com)
  • Most clinical studies have shown that renal denervation can lower high blood pressure in drug-resistant cases, but a number have shown the procedure to be ineffective. (medindia.net)
  • Clearly, it is also important to develop a method to assess the completeness of denervation at the time of the procedure. (medindia.net)
  • Analysis of renal denervation trial, SYMPLICITY HTN-3, shows that the results may be affected by the way the procedure was performed and changes in patients' medications and drug adherence. (medindia.net)
  • Further, with assessment over a 24-hour period, renal denervation, as compared with sham procedure, was associated with a persistent consistent reduction in BP at all time intervals. (healio.com)
  • This invasive procedure is called radiofrequency denervation. (cochrane.org)
  • Radiofrequency denervation is an invasive procedure that can cause a variety of complications. (cochrane.org)
  • Unlike surgical sympathectomy, renal denervation is a minimally invasive, endovascular catheter-based procedure performed via femoral access. (bmj.com)
  • The modest blood pressure benefit directly assignable to renal denervation should be balanced with unresolved safety issues, such as potentially increased risk of renal artery stenosis after the procedure (more than ten cases reported up to now, most of them in 2014), unclear long-term impact on renal function and lack of morbidity-mortality data. (springer.com)
  • Moreover, increasing clinical trials to validate clinical efficacy of renal denervation and cost effectiveness of the procedure over conventional surgeries are expected to offer high growth opportunities for players active in the global renal denervation systems market. (marketsandmarkets.com)
  • It considered sympathetic denervation of the renal artery to be a promising procedure, which might offer benefit to many patients, but a larger evidence base of well-designed trials is required. (nice.org.uk)
  • During the renal denervation procedure with the Symplicity device used in this trial, a catheter is threaded through arteries to deliver radiofrequency energy that inactivates kidney nerves, interrupting electrical signals to and from the kidney, an organ that performs a major role in regulating blood pressure. (medicalxpress.com)
  • However, sympathectomy has been abandoned due to the procedure being too invasive, and RDN resulted in variation in blood pressure reduction between patients due to suboptimal denervation. (embs.org)
  • These effects persisted for at least several months after PADN, suggesting that the procedure produces a permanent sympathetic denervation of the pulmonary arterial tree. (onlinejacc.org)
  • The global, sham-controlled study evaluated 331 patients-166 of whom were randomized to renal denervation (RDN), a minimally invasive procedure intended to regulate overactivity of nerves that lead to and from the kidney. (globenewswire.com)
  • The objective of this study is to evaluate the early results of this operation combined with a selective intra-abdominal denervation in diabetic patients with BMI below 35.The procedure was performed in 33 patients. (sages.org)
  • Translational medicine: the antihypertensive effect of renal denervation. (nih.gov)
  • To determine the effect of renal denervation (RDN) on the severity of atherosclerosis and aortic aneurysm in hypertensive mice. (frontiersin.org)
  • The prospective, open, randomized, trial was conducted at 3 centers in Prague to evaluate the effect of renal denervation with the Symplicity catheters compared with intensified antihypertensive therapy including spironolactone 25 mg on 24-hour blood pressure. (eshonline.org)
  • Introduction: The effect of renal sympathetic denervation (RDN) on neurohormonal responses is largely unknown. (eur.nl)
  • Initial studies have shown that renal denervation is able to reduce not only blood pressure but also heart rate, and is associated with a reduction in myocardial hypertrophy, improved glucose tolerance, and ameliorated microalbuminuria. (ovid.com)
  • Compared with sham, denervation was also associated with a significant decrease in daytime ambulatory systolic blood pressure, office systolic blood pressure, 24-hour ambulatory diastolic blood pressure, daytime ambulatory diastolic blood pressure, and office diastolic blood pressure. (medscape.com)
  • In these patients, renal denervation may reduce systolic blood pressure by approximately 20 percent, thereby greatly reducing the risk of stroke and cardiovascular disease. (medgadget.com)
  • Additionally, ambulatory BP assessment over 24 hours at baseline, 3 months and 6 months showed a trajectory of progressive decline in BP for patients receiving renal denervation therapy for both systolic and diastolic BP measures, Kandzari noted. (healio.com)
  • The use of a sound methodology, including randomisation and blinded endpoint assessment was enough to see the typical 25-30 mmHg systolic blood pressure decrease observed after renal denervation melt down to less than 3 mmHg, the rest being likely explained by Hawthorne and placebo effects, attenuation of white coat effect, regression to the mean and other physician and patient-related biases. (springer.com)
  • The new trial builds on the success of Enlightn I, in which researchers concluded that treatment with St. Jude's renal denervation system produced significant and sustained reduction in systolic blood pressure. (massdevice.com)
  • Renal denervation failed to achieve the primary efficacy endpoint of a decrease in systolic blood pressure measured in the doctor's office from baseline to six months or the powered secondary efficacy endpoint of decrease in average 24-hour levels by ambulatory blood pressure monitoring, which provides more reliable readings. (medicalxpress.com)
  • Although both study groups showed a statistically significant decrease at six months compared with baseline (-14.1 mmHg for renal denervation compared to -11.7 mmHg for the sham treatment control), the difference of -2.29 mmHg in office systolic blood pressure between the two arms was not significant. (medicalxpress.com)
  • Despite large reductions in blood pressure seen in early studies of renal denervation, the SYMPLICITY HTN-3 randomized trial failed to show a reduction in systolic blood pressure with renal denervation when compared to medical therapy alone. (bmj.com)
  • At 12 months, a significant reduction from baseline in systolic blood pressure (SBP) measured in the office was found within the renal denervation group and within the medical treatment group, but there was no between-group difference for this reduction ( Figure 1 ). (eshonline.org)
  • Unfortunately, in the largest and most rigorous trial to be done - SYMPLICITY HTN-3 - there was no difference between medical therapy and denervation. (medscape.com)
  • Other studies -- including the Global SYMPLICITY post-market surveillance registry and studies looking at renal denervation for other conditions -- will continue. (medpagetoday.com)
  • Bilateral renal denervation will be performed using the Symplicity Catheter - a percutaneous system that delivers radiofrequency (RF) energy through the luminal surface of the renal artery. (clinicaltrials.gov)
  • The Symplicity Renal Denervation System is estimated to continue to generate the highest revenue for the entire forecast period as the number of product approvals worldwide increases. (openpr.com)
  • Based on product type, Symplicity Renal Denervation System sector is the largest and Vessix Renal Denervation System is expected to grow at the fastest rate. (openpr.com)
  • Whitbourn R, Harding SA, Walton A. Symplicity multi-electrode radiofrequency renal denervation system feasibility study. (clinicaltrials.gov)
  • MDT ) said it's closed the 1st phase of a feasibility trial for its next-generation Symplicity renal denervation device for high blood pressure. (mdtmag.com)
  • After three years of excessive confidence, overoptimistic expectations and performance of 15 to 20,000 renal denervation procedures in Europe, the failure of a single well-designed US trial-Symplicity HTN-3-to meet its primary efficacy endpoint has cast doubt on renal denervation as a whole. (springer.com)
  • St. Jude last year touted study results finding that its Enlightn renal denervation system lowered high blood pressure faster than Medtronic's Symplicity. (massdevice.com)
  • There are already four radiofrequency devices that have received a CE mark for catheter-delivered renal denervation in Europe: St. Jude Medical's EnligHTN, Medtronic's Symplicity, Covidien's OneShot and Vessix Vascular's Vessix 2. (managedcaremag.com)
  • In response to the announcement of the Symplicity HTN-3 study results earlier this year, the Joint UK Societies' issued an initial response suggesting a temporary moratorium on the use of renal denervation in the UK until further advice (RA eNews February 2014). (renal.org)
  • Along with the Global Symplicity Registry, conducted outside the United States, Medtronic's renal denervation program includes more than 4,000 patients, studied in the presence and absence of medication, and in patients with high baseline cardiovascular risk. (globenewswire.com)
  • SYMPLICITY HTN-3, the eagerly awaited first rigorous test of renal denervation, shows that the real effect of the novel blood-pressure-lowering technology is dramatically lower than earlier expectations, which had been fueled by data from previous uncontrolled trials. (jwatch.org)
  • The study was not powered for statistical significance but "provides biologic proof of principle for the efficacy of renal denervation" and will inform the design of a larger pivotal trial, co-primary investigator Dr Michael Böhm (University Hospital of Saarland, Homburg/Saar, Germany) reported here at the European Society of Cardiology (ESC) Congress 2017 . (medscape.com)
  • Altogether, the present study affirms the safety and efficacy of renal denervation for blood pressure reduction and highlights the importance of incorporating the previously described modifications in trial design," the authors write. (medscape.com)
  • The 433-patient SPYRAL HTN trial is part of the broader SPYRAL HTN Global Clinical Program, a multi-phased clinical study strategy aimed to establish the safety and efficacy of renal denervation to lower blood pressure. (mddionline.com)
  • These data increase CBSET's insight into the connection between target anatomy and patient efficacy post-renal denervation by single and multiple RF electrode catheters. (businesswire.com)
  • Nonetheless, these results may provide some added insights into early procedural efficacy and durability after renal denervation. (brightsurf.com)
  • Identification of the pathogenetic mechanisms involved in the fall in blood pressure after renal denervation may help to identify those hypertensive patients that profit most from renal nerve ablation in terms of blood pressure reduction. (clinicaltrials.gov)
  • ReCor Medical was created in 2009 by Sofinnova Partners and has developed the Paradise System, an ultrasound ablation system for renal denervation. (mddionline.com)
  • Methods and apparatus are provided for selective denervation of conduction pathways in the heart for the treatment of dysrhythmias, including one or more ablation or electroporation catheters having electrodes for stimulating, targeting, and ablating fat pad tissue and other cardiac tissue to selectively. (google.es)
  • All measurements were repeated 3 months after bilateral renal denervation achieved via percutaneous endovascular radiofrequency ablation. (nih.gov)
  • Aims To evaluate 'targeted lung denervation' (TLD), a novel bronchoscopic therapy based on ablation of parasympathetic pulmonary nerves surrounding the main bronchi, as a potential therapy for COPD. (bmj.com)
  • Dr. Rami Tzafriri , Principal Scientist and computational modeling expert at CBSET, will present: "Renal Norepinephrine Reduction Following Radiofrequency Renal Denervation Correlates with Extent of Nerve Ablation: Roles of Ablation Areas, Anatomy, and Number of Treatments", on Saturday, Sept. 13, 2:40 p.m. (businesswire.com)
  • Effective December 10, 2019 , Horizon BCBSNJ will change the way we consider certain professional claims based on the implementation of our new¹ medical policy, Radiofrequency Joint Ablation/Denervation. (horizonblue.com)
  • Little is known about the extent of vagal denervation and recovery of parasympathetic function after ablation.This study examined electrophysiological changes in parasympathetic response to the atria after surgical ablation. (ahajournals.org)
  • So we can't become too excited about these data referable to clinical application, but what we can do is accept the fact that these data initiate the conversations again about renal denervation. (medscape.com)
  • Steffen Desch, MD, of the University of Leipzig Heart Center, who reported the findings at a late-breaking clinical trial session at the Transcatheter Cardiovascular Therapeutics meeting here, told MedPage Today that renal sympathetic denervation "may have an application in science, but not in the clinic except for the very rare patient. (medpagetoday.com)
  • Over the next several weeks, the company will collaborate with physicians and the renal denervation community to ensure existing OneShot patients are informed and the currently enrolling clinical trials are transitioned appropriately. (mdtmag.com)
  • The patented RF balloon catheter connects to a proprietary bipolar RF generator specifically designed and optimized for the renal denervation clinical application. (medgadget.com)
  • This observation is contrary to clinical trials in humans that supported that the effectiveness of renal denervation depended on blood pressure level, says John Osborn of the University of Minnesota and lead investigator of the study. (medindia.net)
  • There were no major adverse events at 6 months in the overall study population, but more specifically, in the renal denervation cohort, there were no major clinical events, including no new renal artery stenosis or worsening renal function and no major bleeding or vascular complications, Kandzari reported. (healio.com)
  • Renal nerve denervation (RND) entered clinical trials backed by strong preclinical evidence alongside decades of clinical research confirming the strong contribution of the adrenergic system to the hypertensive continuum. (springer.com)
  • We look forward to moving forward with our clinical evaluation of this next-generation system that aims to augment our portfolio by offering more sophisticated features that should benefit both physicians and patients,' Medtronic's president of coronary & renal denervation Sean Salmon said in prepared remarks. (mdtmag.com)
  • Accordingly, there is no doubt that renal denervation is not ready for clinical use. (springer.com)
  • Medtronic is also the closest to winning FDA approval for renal denervation, with U.S. clinical trials approved in the summer of 2011 . (massdevice.com)
  • Here we propose a minimally invasive Laparoscopic Denervation System (LDS) to serve this unmet clinical need. (embs.org)
  • Medtronic and Boston Scientific have announced plans to start phase 2 clinical trials this year for their updated renal denervation catheters. (jwatch.org)
  • 2 Muscle denervation is a major clinical feature of MND and results in fluid shifts detectable as altered T2 signal characteristics 3 that, in contrast to clinical assessments, are independent of participant's effort and premorbid abilities. (bmj.com)
  • Although impulsive choices are exacerbated in PD patients with ICDs under DRTs, some clinical and preclinical studies suggest that the DA denervation of the dorsal striatum induced by the neurodegenerative process as well as a pre-existing high impulsivity trait, may both contribute to the emergence of ICDs in PD. (frontiersin.org)
  • The demonstration of cholinergic denervation with an anatomy that fits the clinical picture suggests that cholinergic treatment is justified in patients with PPA who have positive AD biomarkers. (neurology.org)
  • The global renal denervation systems market is poised to witness a steady growth during the forecast period. (marketsandmarkets.com)
  • Boston Scientific Corporation, St. Jude Medical, Inc., ReCor Medical, Inc., Cordis Corporation, and Terumo Corporation are some of the key players present in global renal denervation systems market. (marketsandmarkets.com)
  • global renal denervation market size is expected to reach USD 1.03 billion by 2026, according to a new report by the Grand View Research, Inc. The market is estimated to register a CAGR of 43.2% during the forecast period. (medindia.net)
  • Publisher's analysts forecast the global renal denervation market to grow at a CAGR of 11.82% during the period 2016-2020. (emailwire.com)
  • The report covers the present scenario and the growth prospects of the global renal denervation market for 2016-2020. (emailwire.com)
  • Publisher's report, Global Renal Denervation Market 2016-2020, has been prepared based on an in-depth market analysis with inputs from industry experts. (emailwire.com)
  • This magnified image of type 2 muscle fibers shows denervation atrophy occurring at the white spaces at the top left and bottom center of the image. (wikipedia.org)
  • The motor unit areas soon increase to a point where reinnervation is no longer possible causing an uncompensated denervation of motor units which leads to muscle atrophy and loss of muscular strength. (wikipedia.org)
  • Following denervation, muscular atrophy and degeneration occurs within affected skeletal muscle tissue. (wikipedia.org)
  • The CT findings of denervation atrophy due to CN VII dysfunction have been reported. (ajnr.org)
  • Because blocking myostatin in an adult wild-type mouse induces profound muscle hypertrophy, we applied a soluble ActRIIB receptor to models of disuse (limb immobilization) and denervation (sciatic nerve resection) atrophy. (biologists.org)
  • Denervation atrophy, however, was not protected by ActRIIB treatment, yet resulted in an upregulation of the pro-growth factors Akt, SGK and components of the mTOR pathway. (biologists.org)
  • Thus, our studies show that denervation atrophy is not only independent from Akt, SGK and mTOR activation but also has a different underlying pathophysiological mechanism than disuse atrophy. (biologists.org)
  • Muscles biopsies also showed scattered atrophy consistent with the process of denervation. (lexico.com)
  • The DERENEDIAB study is a proof-of-concept, multi-center, prospective, open, randomized, controlled study of the effectiveness of renal denervation in addition to standardized medical treatment compared to medical treatment alone in diabetic subjects with diabetic nephropathy and resistant proteinuria. (clinicaltrials.gov)
  • Our pilot study data indicate interventional treatment with renal denervation decreases blood pressure, and most important, slows or even halts the decline of renal function in treatment-resistant patients with chronic kidney disease," Schmieder said in a statement. (empr.com)
  • Covidien is the latest in a line of companies entering the renal denervation business, as it will unveil its new OneShot renal denervation system at the EuroPCR (European Association for Percutaneous Cardiovascular Interventions) congress in Paris, France, on May 16. (medgadget.com)
  • Key results No high-quality evidence shows that radiofrequency denervation provides pain relief for patients with chronic low back pain. (cochrane.org)
  • Radiofrequency (RF) denervation, an invasive treatment for chronic low back pain (CLBP), is used most often for pain suspected to arise from facet joints, sacroiliac (SI) joints or discs. (cochrane.org)
  • Catheter-based renal sympathetic denervation: chronic preclinical evidence for renal artery safety. (springer.com)
  • Since some experimental and observational data suggest an antiarrhythmic effect, it is possible that renal denervation might also play a therapeutic role in arrhythmias often occurring in chronic heart failure. (ovid.com)
  • Cerebral artery mass in the rabbit is reduced by chronic sympathetic denervation. (ahajournals.org)
  • In addition, the activation of adenyl cyclase by maximal as well as by submaximal concentrations of the catecholamine was potentiated by chronic denervation, indicating that there was more enzyme rather than a greater affinity of adenyl cyclase for norepinephrine. (fluoridealert.org)
  • Denervated muscles undergo a characteristic pattern of changes on MR images as the denervation evolves from an acute phase through a subacute and then chronic phase (2-4) . (ajnr.org)
  • Electrophysiological examination showed evidence of chronic partial denervation and reinnervation only in the upper limb segments. (lexico.com)
  • This is the first blinded trial or sham controlled trial in the field of renal denervation. (medicalxpress.com)
  • Heart failure: The pathophysiology of heart failure seems to support the rationale for renal denervation. (acc.org)
  • The RADIANCE-HTN SOLO trial was a multicenter randomized controlled trial that demonstrated the blood pressure lowering effect of endovascular ultrasound-based renal denervation compared with a sham control. (brightsurf.com)
  • These results are consistent with the primary RADIANCE-HTN SOLO results demonstrating the blood pressure lowering effect of ultrasound-based renal denervation. (brightsurf.com)
  • Based on the reduction in ambulatory SBP from an average of 154 to 148 mm Hg and in office-based SBP from 162 to 152 mm Hg, patients treated with denervation would still need to take medications to achieve currently recommended BP treatment targets, which are only likely to go lower with revision of guidelines around the world, he said. (medscape.com)
  • Spironolactone versus renal nerve denervation for treatment. (lww.com)
  • According to research, renal denervation leads to better outcomes than standard drug treatment in patients with advanced heart failure. (medindia.net)
  • Patients with a positive response to a diagnostic block or to discography were given radiofrequency denervation, a placebo or a comparison treatment. (cochrane.org)
  • The objective of this review is to assess the effectiveness of RF denervation procedures for the treatment of patients with CLBP. (cochrane.org)
  • Cardiac sympathetic denervation for conventional treatment refractory arrhythmias. (medworm.com)
  • We are excited to move forward in our collaboration with Otsuka to make the Paradise renal denervation system a standard of care for treatment of hypertensive patients worldwide," added COO and founder Mano Iyer. (massdevice.com)
  • Patients with high blood pressure and atrial fibrillation might benefit from the regular treatment, which is isolation of the pulmonary veins, by adding renal sympathetic denervation to their treatment. (rug.nl)
  • Renal denervation: a potential new treatment modality for polycystic ovary syndrome? (nih.gov)
  • The major adverse event rate of 1.4 percent for renal denervation comfortably met the safety goal of 9.8 percent, compared with 0.3 percent in the sham treatment arm. (medicalxpress.com)
  • Renal denervation does not involve any pharmacological treatment. (bio-medicine.org)
  • The aim of this pilot study was to compare the outcomes of patients with advanced heart failure receiving standard pharmacological treatment or renal denervation. (bio-medicine.org)
  • Over the period of one year, 26 patients were treated with renal denervation and standard pharmacotherapy and 25 patients received standard drug treatment with beta-blockers, ACE inhibitors or ARBs and diuretics. (bio-medicine.org)
  • The disadvantage of denervation, as with any invasive treatment, is the potential for subsequent complications. (bio-medicine.org)
  • The findings indicate that renal denervation may be a non-pharmacological alternative for the treatment of patients with advanced heart failure and may help stabilise the disease. (bio-medicine.org)
  • The FDA Breakthrough Device Program is intended to help patients receive more timely access to certain technologies, such as renal denervation, that have the potential to provide more effective treatment or diagnosis for life-threatening or irreversibly debilitating diseases or conditions. (globenewswire.com)
  • I believe there's a logical reason why renal denervation may be a useful approach in this area," he stated, "and it may expand treatment over and above the neurohormonal blockade and other pharmacological therapies available today. (acc.org)
  • In this study, patients were randomized to renal denervation or intensified medical treatment. (eshonline.org)
  • The 51 patients in the renal denervation group and the 50 patients in the medical treatment group were similar at baseline, except the body mass index (BMI) was significantly higher in the medical treatment group ( Table 1 and Table 2 ). (eshonline.org)
  • In contrast, in the PP analysis, a significant between-group difference was found, based on a greater reduction in 24-hour SBP in the medical treatment group than in the renal denervation group (15 mmHg vs 6.3 mmHg, respectively). (eshonline.org)
  • The renal denervation catheter is introduced through the femoral artery in the upper thigh. (emailwire.com)
  • Cardiac sympathetic denervation preceding motor signs in Parkinson disease. (biomedsearch.com)
  • Left cardiac sympathetic denervation (LCSD) suppresses ventricular arrhythmias (VAs), and reduces the incidence of sudden cardiac death (SCD). (ahajournals.org)
  • The role of bilateral cardiac sympathetic denervation (BCSD) remains unknown. (ahajournals.org)
  • Surgical BCSD was successfully performed in all patients (50% simultaneously, 50% right cardiac sympathetic denervation after prior unsuccessful LCSD). (ahajournals.org)
  • In these patients with electrical storm refractory to standard therapies, bilateral cardiac sympathetic denervation was safe and effective in acutely suppressing VAs, and preventing SCD. (ahajournals.org)
  • 123)I-Labelled metaiodobenzylguanidine for the evaluation of cardiac sympathetic denervation in early stage amyloidosis. (biomedsearch.com)
  • This feasibility study represents Medtronic's commitment to providing physicians with a broader range of solutions for performing renal denervation and to collaborating with physician partners in the ongoing evaluation of this ground-breaking therapy. (mdtmag.com)
  • Annualized total Renal Denervation market revenue by segment and market outlooks from 2018-2024. (reportbuyer.com)
  • Annualized US renal denervation market revenue and future forecasts from 2009 to 2011, forecast for 7 years to 2018. (globaldialysis.com)
  • Access market sizing, forecasts and quantified growth opportunities in the US renal denervation market through 2018. (globaldialysis.com)
  • During renal sympathetic denervation, a catheter is introduced using standard interventional technique via the femoral artery, and is positioned in the renal artery under fluoroscopic guidance. (terumo-europe.com)
  • However, Medtronic received FDA approval in May for a pivotal trial to evaluate the Simplicity Renal Denervation System for patients with high blood pressure. (mddionline.com)
  • Those with post polio syndrome are undergoing a constant process of denervation and reinnervation . (wikipedia.org)
  • This process of denervation is however different from post-polio syndrome in that it only involves upper and lower motor neuron degeneration and does not experience a process of constant reinnervation and denervation. (wikipedia.org)
  • In addition, T2 prolongation and postcontrast enhancement were identified in the right-sided muscles of mastication and muscles of facial expression, consistent with denervation change. (ajnr.org)
  • A muscle biopsy confirmed neuropathic changes in a pattern consistent with denervation. (lexico.com)
  • Otsuka Holdings is set to acquire ReCor Medical for an undisclosed sum and follows Medtronic in a bid to get a renal denervation device on the market. (mddionline.com)
  • The Medtronic Multi-electrode Radiofrequency Renal Denervation System is comprised of a single-use, disposable catheter and a reusable generator. (clinicaltrials.gov)
  • If your blood pressure is normal but you are on many medications, could renal denervation enable you to reduce or eliminate lifelong medications? (huffingtonpost.com)
  • Indeed, in 10 patients, blood pressure actually increased after denervation. (medscape.com)
  • A new meta-analysis of six sham-controlled studies of renal sympathetic denervation (RSD) has shown a significant reduction in blood pressure with the technique. (medscape.com)
  • Aronow explained that a number of early studies suggested that renal sympathetic denervation was associated with reduced blood pressure, and the results with surgical denervation were very positive. (medscape.com)
  • Later studies have included more extensive denervation than earlier studies and also have used ambulatory blood pressure monitoring to assess pressures over the full 24-hour period, which are much more reliable, he said. (medscape.com)
  • This meta-analysis as a whole has shown a significant benefit of denervation over sham control, but when we looked at the more recent trials we saw a larger reduction in blood pressure with denervation than was seen in the earlier trials. (medscape.com)
  • In recent years, concerns have been raised that the magnitude of the blood pressure reductions seen in renal denervation studies without control groups would not hold up in controlled trials, and those concerns now appear to be well founded. (medpagetoday.com)
  • There is ample data that renal denervation reduces blood pressure in animal models and in smaller human trials, and there are at least 30 different methods being tested to denervate the renal arteries. (medpagetoday.com)
  • In our case, we present a 39-year-old patient with high blood pressure (BP) of 10-year evolution, left ventricular hypertrophy, and left putaminal hypertensive intracranial hemorrhage, which occurred one year before denervation. (ahajournals.org)
  • Renal denervation achieved by intravascular delivery of radiofrequency energy or ultrasound energy might produce similar blood pressure lowering and the RADIANCE-HTN SOLO and SPYRAL trials take the renal denervation field into a new era. (healio.com)
  • This thesis is a collection of research regarding high blood pressure and renal sympathetic denervation. (rug.nl)
  • These findings corroborate the relevance of sympathetic activation in PCOS and suggest that renal denervation exerts beneficial effects not only on blood pressure control but also on insulin sensitivity, renal, and endocrine abnormalities characteristic of PCOS. (nih.gov)
  • Still, renal denervation is supported by a strong rationale and is occasionally followed by major blood pressure responses in at-risk patients who may otherwise have remained uncontrolled. (springer.com)
  • 2. Chemical denervation reduced the blood pressure of both strains of rats, but the denervated spontaneously hypertensive rats were still hypertensive with respect to their denervated Wistar-Kyoto controls. (portlandpress.com)
  • Covidien [1] plc has announced it will exit its OneShot Renal Denervation program. (mdtmag.com)
  • If the nerves lost to denervation are part of the neuronal communication to a specific function in the body then altered or a loss of physiological functioning can occur. (wikipedia.org)
  • The thesis shows the results of enhancement of the regular renal denervation with a technique that uses electrical energy to find these sympathetic nerves. (rug.nl)
  • Conclusions- CHEP offers a noninvasive approach to evaluate the degeneration of thermonociceptive nerves in diabetic neuropathy by providing physiological correlates of skin denervation and neuropathic pain. (diabetesjournals.org)
  • It is a multiple application of radiofrequency energy using a thin catheter via the femoral artery and a long-term "denervation" of the sympathetic nerves around the renal arteries. (bio-medicine.org)
  • Summary: Denervation changes in muscle following damage to cranial and peripheral nerves can be observed on both CT and MR imaging studies. (ajnr.org)
  • He concluded: "The long-term effects of renal denervation should be confirmed in a large international randomised study. (bio-medicine.org)
  • Lastly, the book focuses on the cost effectiveness of renal denervation and future directions for other possible benefits. (springer.com)
  • Written by world renowned leaders in the field, Renal Denervation will be of immediate use to cardiologists, nephrologists and urologists as well as allied health professionals, device companies and anyone working in this field. (springer.com)
  • Numerous medical device news sources and industry executives have proclaimed renal denervation to be the top medical device breakthrough of the past two years, and for good reason. (globaldialysis.com)
  • These differences were obtained with a similar number of anti-hypertensives and drug-adherence in both groups as well as an acceptable safety profile for the intervention (three minor adverse events with renal denervation and a comparable decrease in estimated glomerular filtration rate in both groups). (bmj.com)
  • The renal denervation market in the United States will grow from essentially nothing in 2012 as the intervention was not approved for any indication in the United States in 2012. (globaldialysis.com)
  • The researchers suggest the better results with denervation in the second-generation studies might be explained by differences in patients enrolled, procedural technique employed, antihypertensive drug regimens prescribed, and endpoint ascertainment. (medscape.com)
  • Following an acute polio infection diagnosis symptoms such as fatiguability , general weakness and pain are believed to be correlated to muscle denervation. (wikipedia.org)
  • In regard to skeletal muscle denervation there are two distinct diagnoses: entrapment and compressive neuropathies or non-entrapment neuropathies. (wikipedia.org)
  • MR imaging has the advantage of providing some earlier insight into the pathophysiological changes that accompany muscle denervation, and also sensitivity to the time course of the process. (ajnr.org)