Autonomic Denervation
Sympathectomy
Parasympathectomy
Sympathetic Nervous System
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Sympathectomy, Chemical
Muscular Atrophy
Pressoreceptors
Muscle, Skeletal
Vagotomy
Carotid Sinus
Kidney
Vagus Nerve
The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).
Cranial Nerve Diseases
Receptors, Cholinergic
Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Sciatic Nerve
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
3-Iodobenzylguanidine
A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
Oxidopamine
Autonomic Nervous System Diseases
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Parasympathetic Nervous System
The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system.
Carotid Body
A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.
Reflex
Diaphragm
Rats, Inbred Strains
Dogs
Rats, Sprague-Dawley
Glossopharyngeal Nerve
The 9th cranial nerve. The glossopharyngeal nerve is a mixed motor and sensory nerve; it conveys somatic and autonomic efferents as well as general, special, and visceral afferents. Among the connections are motor fibers to the stylopharyngeus muscle, parasympathetic fibers to the parotid glands, general and taste afferents from the posterior third of the tongue, the nasopharynx, and the palate, and afferents from baroreceptors and CHEMORECEPTOR CELLS of the carotid sinus.
Rats, Wistar
Hindlimb
Muscle Contraction
Electromyography
Chemoreceptor Cells
Motor Endplate
Muscle Proteins
Baroreflex
A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.
Edrophonium
Muscle Fibers, Skeletal
Large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of SKELETAL MUSCLE. They consist of MYOFIBRILS enclosed within and attached to the SARCOLEMMA. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation.
Muscle Fibers, Fast-Twitch
Tyramine
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
Shy-Drager Syndrome
A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)
Trigeminal Nerve
The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
Diuresis
Hyperhidrosis
Sympatholytics
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
Cats
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Ephedrine
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Hypoglossal Nerve
Sodium Cyanide
Autonomic Fibers, Preganglionic
NERVE FIBERS which project from the central nervous system to AUTONOMIC GANGLIA. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the SPINAL CORD, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in SYNAPSES or continue through the SPLANCHNIC NERVES to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the BRAIN STEM and sacral spinal cord. In both divisions the principal transmitter is ACETYLCHOLINE but peptide cotransmitters may also be released.
Autonomic Fibers, Postganglionic
Stellate Ganglion
Primary Dysautonomias
Hypertension
Nerve Degeneration
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Pure Autonomic Failure
Atrophy
Myogenin
Ganglia, Sympathetic
Acetylcholine
Peripheral Nerves
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Tongue
Nerve Fibers
Muscle Development
Neural Conduction
Botulinum Toxins
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
Acetylcholinesterase
Tibial Nerve
Sinoatrial Node
The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).
Nerve Endings
Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
Catheter Ablation
Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.
Afferent Pathways
Nervous System Physiological Phenomena
Tetrodotoxin
Nictitating Membrane
Autonomic Nervous System
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Muscle Fibers, Slow-Twitch
Ganglia, Parasympathetic
Muscular Disorders, Atrophic
Disorders characterized by an abnormal reduction in muscle volume due to a decrease in the size or number of muscle fibers. Atrophy may result from diseases intrinsic to muscle tissue (e.g., MUSCULAR DYSTROPHY) or secondary to PERIPHERAL NERVOUS SYSTEM DISEASES that impair innervation to muscle tissue (e.g., MUSCULAR ATROPHY, SPINAL).
Paralysis
Bungarotoxins
Neurotoxic proteins from the venom of the banded or Formosan krait (Bungarus multicinctus, an elapid snake). alpha-Bungarotoxin blocks nicotinic acetylcholine receptors and has been used to isolate and study them; beta- and gamma-bungarotoxins act presynaptically causing acetylcholine release and depletion. Both alpha and beta forms have been characterized, the alpha being similar to the large, long or Type II neurotoxins from other elapid venoms.
Masticatory Muscles
Ganglia, Autonomic
Clusters of neurons and their processes in the autonomic nervous system. In the autonomic ganglia, the preganglionic fibers from the central nervous system synapse onto the neurons whose axons are the postganglionic fibers innervating target organs. The ganglia also contain intrinsic neurons and supporting cells and preganglionic fibers passing through to other ganglia.
Guanethidine
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
Propranolol
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
Neuromuscular Diseases
Hemodynamics
Ophthalmic Nerve
Disease Models, Animal
Sciatic Neuropathy
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Atropine
Efferent Pathways
Diabetic Neuropathies
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
Mandibular Nerve
Iris
Receptors, Adrenergic
Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.
Facial Nerve
The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and SALIVARY GLANDS, and convey afferent information for TASTE from the anterior two-thirds of the TONGUE and for TOUCH from the EXTERNAL EAR.
Reserpine
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
Respiration
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Sympathomimetics
Striatonigral Degeneration
A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6)
Action Potentials
Epinephrine
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Schwann Cells
Phenylephrine
Calcitonin Gene-Related Peptide
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
Spinal Nerve Roots
Paired bundles of NERVE FIBERS entering and leaving the SPINAL CORD at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots are efferent, comprising the axons of spinal motor and PREGANGLIONIC AUTONOMIC FIBERS.
Tyrosine 3-Monooxygenase
Hexamethonium Compounds
Dopamine
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Chorda Tympani Nerve
Peroneal Nerve
Myosin Heavy Chains
Prenalterol
Corpus Striatum
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Vascular Resistance
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Dihydroergotamine
Phentolamine
Sweat Glands
Sodium
Possible role of serotonin in Merkel-like basal cells of the taste buds of the frog, Rana nigromaculata. (1/1756)
Merkel-like basal cells in the taste buds of the frog were examined by fluorescence histochemistry, immunohistochemistry and electron microscopy. There were about 16-20 basal cells arranged in a radial fashion at the base of each taste bud. These cells were strongly immunopositive for serotonin antiserum. They were characterised by the presence of numerous dense-cored granules in the cytoplasm ranging from 80 to 120 nm in diameter, and of microvilli protruding from the cell surface. For 4 mo after sensory denervation by cutting the gustatory nerves, all cell types of the taste bud were well preserved and maintained their fine structure. Even at 4 mo after denervation, the basal cells exhibited a strong immunoreaction with serotonin antiserum. To investigate the function of serotonin in the basal cells in taste bud function, serotonin deficiency was induced by administration of p-chlorophenylalanine (PCPA), an inhibitor of tryptophan hydroxylase, and of p-chloroamphetamine (PCA), a depletor of serotonin. After administration of these agents to normal and denervated frogs for 2 wk, a marked decrease, or complete absence, of immunoreactivity for serotonin was observed in the basal cells. Ultrastructurally, degenerative changes were observed in both types of frog; numerous lysosome-like myelin bodies were found in all cell types of the taste buds. The number of dense-cored granules in the basal cells also was greatly decreased by treatment with these drugs. Serotonin in Merkel-like basal cells appears to have a trophic role in maintenance of the morphological integrity of frog taste bud cells. (+info)Expression of Mash1 in basal cells of rat circumvallate taste buds is dependent upon gustatory innervation. (2/1756)
Mash1, a mammalian homologue of the Drosophila achaete-scute proneural gene complex, plays an essential role in differentiation of subsets of peripheral neurons. In this study, using RT-PCR and in situ RT-PCR, we investigated if Mash1 gene expression occurs in rat taste buds. Further, we examined dynamics of Mash1 expression in the process of degeneration and regeneration in denervated rat taste buds. In rat tongue epithelium, Mash1 gene expression is confined to circumvallate, foliate, and fungiform papilla epithelia that include taste buds. In taste buds, Mash1-expressing cells are round cells in the basal compartment. In contrast, the mature taste bud cells do not express the Mash1 gene. Denervation and regeneration experiments show that the expression of Mash1 requires gustatory innervation. We conclude that Mash1 is expressed in cells of the taste bud lineage, and that the expression of Mash1 in rat taste buds is dependent upon gustatory innervation. (+info)Effect of central corticotropin-releasing factor on carbon tetrachloride-induced acute liver injury in rats. (3/1756)
Central neuropeptides play important roles in many instances of physiological and pathophysiological regulation mediated through the autonomic nervous system. In regard to the hepatobiliary system, several neuropeptides act in the brain to regulate bile secretion, hepatic blood flow, and hepatic proliferation. Stressors and sympathetic nerve activation are reported to exacerbate experimental liver injury. Some stressors are known to stimulate corticotropin-releasing factor (CRF) synthesis in the central nervous system and induce activation of sympathetic nerves in animal models. The effect of intracisternal CRF on carbon tetrachloride (CCl4)-induced acute liver injury was examined in rats. Intracisternal injection of CRF dose dependently enhanced elevation of the serum alanine aminotransferase (ALT) level induced by CCl4. Elevations of serum aspartate aminotransferase, alkaline phosphatase, and total bilirubin levels by CCl4 were also enhanced by intracisternal CRF injection. Intracisternal injection of CRF also aggravated CCl4-induced hepatic histological changes. Intracisternal CRF injection alone did not modify the serum ALT level. Intravenous administration of CRF did not influence CCl4-induced acute liver injury. The aggravating effect of central CRF on CCl4-induced acute liver injury was abolished by denervation of hepatic plexus with phenol and by denervation of noradrenergic fibers with 6-hydroxydopamine treatment but not by hepatic branch vagotomy or atropine treatment. These results suggest that CRF acts in the brain to exacerbate acute liver injury through the sympathetic-noradrenergic pathways. (+info)Nitric oxide mediates sympathetic vasoconstriction at supraspinal, spinal, and synaptic levels. (4/1756)
The purposes of this study were to investigate the level of the sympathetic nervous system in which nitric oxide (NO) mediates regional sympathetic vasoconstriction and to determine whether neural mechanisms are involved in vasoconstriction after NO inhibition. Ganglionic blockade (hexamethonium), alpha1-receptor blockade (prazosin), and spinal section at T1 were used to study sympathetic involvement. NO was blocked with Nomega-nitro-L-arginine methyl ester (L-NAME). Regional blood flow in the mesenteric and renal arteries and terminal aorta was monitored by electromagnetic flowmetry in conscious rats. L-NAME (3-5 mg/kg iv) increased arterial pressure and peripheral resistance. Ganglionic blockade (25 mg/kg iv) significantly reduced the increase in resistance in the mesentery and kidney in intact and spinal-sectioned rats. Ganglionic blockade significantly decreased hindquarter resistance in intact rats but not in spinal-sectioned rats. Prazosin (200 micrograms/kg iv) significantly reduced the increased hindquarter resistance. We concluded that NO suppresses sympathetic vasoconstriction in the mesentery and kidney at the spinal level, whereas hindquarter tone is mediated at supraspinal and synaptic levels. (+info)Erythromycin enhances early postoperative contractility of the denervated whole stomach as an esophageal substitute. (5/1756)
OBJECTIVE: To determine whether early postoperative administration of erythromycin accelerates the spontaneous motor recovery process after elevation of the denervated whole stomach up to the neck. SUMMARY BACKGROUND DATA: Spontaneous motor recovery after gastric denervation is a slow process that progressively takes place over years. METHODS: Erythromycin was administered as follows: continuous intravenous (i.v.) perfusion until postoperative day 10 in ten whole stomach (WS) patients at a dose of either 1 g (n = 5) or 2 g (n = 5) per day; oral intake at a dose of 1 g/day during 1.5 to 8 months after surgery in 11 WS patients, followed in 7 of them by discontinuation of the drug during 2 to 4 weeks. Gastric motility was assessed with intraluminal perfused catheters in these 21 patients, in 23 WS patients not receiving erythromycin, and in 11 healthy volunteers. A motility index was established by dividing the sum of the areas under the curves of >9 mmHg contractions by the time of recording. RESULTS: The motility index after IV or oral administration of erythromycin at and after surgery was significantly higher than that without erythromycin (i.v., 1 g: p = 0.0090; i.v., 2 g: p = 0.0090; oral, 1 g: p = 0.0017). It was similar to that in healthy volunteers (i.v., 1 g: p = 0.2818; oral, 1 g: p = 0.7179) and to that in WS patients with >3 years of follow-up who never received erythromycin (i.v., 1 g: p = 0.2206; oral, 1 g: p = 0.8326). The motility index after discontinuation of the drug was similar or superior to that recorded under medication in four patients who did not experience any modification of their alimentary comfort, whereas it dropped dramatically parallel to deterioration of the alimentary comfort in three patients. CONCLUSIONS: Early postoperative contractility of the denervated whole stomach pulled up to the neck under either i.v. or oral erythromycin is similar to that recovered spontaneously beyond 3 years of follow-up. In some patients, this booster effect persists after discontinuation of the drug. (+info)Heterogeneous cardiac sympathetic denervation and decreased myocardial nerve growth factor in streptozotocin-induced diabetic rats: implications for cardiac sympathetic dysinnervation complicating diabetes. (6/1756)
Heterogeneous myocardial sympathetic denervation complicating diabetes has been invoked as a factor contributing to sudden unexplained cardiac death. In subjects with diabetic autonomic neuropathy (DAN), distal left ventricular (LV) denervation contrasts with preservation of islands of proximal innervation, which exhibit impaired vascular responsiveness. The aims of this study were to determine whether this heterogeneous pattern of myocardial sympathetic denervation occurs in a rat model of diabetes and to explore a potential association with regional fluctuations in myocardial nerve growth factor (NGF) protein. Myocardial sympathetic denervation was characterized scintigraphically using the sympathetic neurotransmitter analog C-11 hydroxyephedrine ([11C]HED) and compared with regional changes in myocardial NGF protein abundance and norepinephrine content after 6 and 9 months in nondiabetic (ND) and streptozotocin-induced diabetic (STZ-D) rats. In ND rats, no difference in [11C]HED retention or norepinephrine content was detected in the proximal versus distal myocardium. After 6 months, compared with ND rats, myocardial [11C]HED retention had declined in the proximal segments of STZ-D rats by only 9% (NS) compared with a 33% decrease in the distal myocardium (P < 0.05). Myocardial norepinephrine content was similar in both ND and STZ-D rats. At 6 months, LV myocardial NGF protein content in STZ-D rats decreased by 52% in the proximal myocardial segments (P < 0.01 vs. ND rats) and by 82% distally (P < 0.01 vs. ND rats, P < 0.05 vs. proximal segments). By 9 months, [11C]HED retention had declined in both the proximal and distal myocardial segments of the STZ-D rats by 42% (P < 0.01 vs. ND rats), and LV norepinephrine content and NGF protein were decreased in parallel. Therefore, 6 months of STZ-induced diabetes results in heterogeneous cardiac sympathetic denervation in the rat, with maximal denervation occurring distally, and is associated with a proximal-to-distal gradient of LV NGF protein depletion. It is tempting to speculate that regional fluctuations of NGF protein in the diabetic myocardium contribute to heterogeneous cardiac sympathetic denervation complicating diabetes. (+info)Hypoxia inhibits baroreflex vagal bradycardia via a central action in anaesthetized rats. (7/1756)
It is known that arterial baroreflexes are suppressed in stressful conditions. The present study was designed to determine whether and how hypoxia affects arterial baroreflexes, especially the heart rate component, baroreflex vagal bradycardia. In chloralose-urethane-anaesthetized rats, baroreflex vagal bradycardia was evoked by electrical stimulation of the aortic depressor nerve, and the effect of 15 s inhalation of hypoxic gas (4% O2) was studied. Inhalation of hypoxic gas was found to inhibit baroreflex vagal bradycardia. The inhibition persisted after bilateral transection of the carotid sinus nerve. Cervical vagus nerves were cut bilaterally and their peripheral cut ends were stimulated to provoke vagal bradycardia of peripheral origin so as to determine whether hypoxia could inhibit vagal bradycardia by acting on a peripheral site. In contrast to baroreflex vagal bradycardia, the vagus-induced bradycardia was not affected by hypoxic gas inhalation. It is concluded that baroreflex vagal bradycardia is inhibited by hypoxia and the inhibition is largely mediated by its direct central action. (+info)A substituted dextran enhances muscle fiber survival and regeneration in ischemic and denervated rat EDL muscle. (8/1756)
Ischemia and denervation of EDL muscle of adult rat induce a large central zone of degeneration surrounded by a thin zone of peripheral surviving muscle fibers. Muscle regeneration is a complex phenomenon in which many agents interact, such as growth factors and heparan sulfate components of the extracellular matrix. We have shown that synthetic polymers, called RGTA (as regenerating agents), which imitate the heparan sulfates, are able to stimulate tissue repair when applied at the site of injury. In crushed muscles, RGTA were found to accelerate both regeneration and reinnervation. In vitro, RGTA act as protectors and potentiators of various heparin binding growth factors (HBGF). It was postulated that in vivo their tissue repair properties were due in part to an increase of bioavailability of endogenously released HBGF. In the present work, we show that ischemic and denervated EDL muscle treated by a unique injection of RGTA differs from the control after 1 wk in several aspects: 1) the epimysial postinflammatory reaction is inhibited and the area of fibrotic tissue among fibers is reduced; 2) the peripheral zone, as measured by the number of intact muscle fibers, was increased by more than twofold; and 3) In the central zone, RGTA enhances the regeneration of the muscle fibers as well as muscle revascularization. These results suggest that RGTA both protects muscle fibers from degeneration and preserves the differentiated state of the surviving fibers. For the first time it is demonstrated that a functionalized polymeric compound can prevent some of the damage resulting from muscle ischemia. RGTA may therefore open a new therapeutic approach for muscle fibrosis and other postischemic muscle pathologies. (+info)
Preliminary results of RETREAT renal denervation study go against the grain - Interventional News
Renal Denervation on Quality of 24-hr BP Control by Ultrasound In Resistant Hypertension | Clinical Research Trial Listing (...
The DENERHTN Randomized Controlled Trial: Renal Denervation for Resistant Hypertension Revisited - Heart
Vessix to Present V2 Renal Denervation Systemâ„¢ for Hypertension at LINC 2012
Medtronic announces SPYRAL HTN global clinical trial programme for renal denervation - Interventional News
Arterial wall and smooth muscle cell development in young Wistar rats and the effects of surgical denervation. | Circulation...
Dynamic Analysis of Renal Nerve Activity Responses to Baroreceptor Denervation in Hypertensive Rats | Hypertension
SYMPLICITY HTN-3 Renal Denervation in Patients With Uncontrolled Hypertension - Full Text View - ClinicalTrials.gov
Renal Denervation in Diabetic Nephropathy - Full Text View - ClinicalTrials.gov
Third-generation renal denervation technology presented at CRT15 - ReDy - Third-Generation Renal Denervation
op.7d.10] the Effect of Renal Denervation on Adipokines in Patients with Resistant Hypertension. - Semantic Scholar
Covidien to Exit OneShot Renal Denervation Program
Sinoaortic baroreceptors and the control of blood volume in the nonhuman primate<...
Steady-State and Dynamic Responses of Renal Sympathetic Nerve Activity to Air-Jet Stress in Sinoaortic Denervated Rats |...
Vessix receives the CE mark for V2 Renal Denervation System for treatment of hypertension | Cardiovascular News
Renal Denervation in CKD Hypertensive Patients: Would it be Possible to Prevent the Development of Risk Factors Responsible for...
Renal denervation effective for uncontrolled hypertension in patients not taking medications | News for Doctor, Nurse,...
News for Medical Independent Sales Representatives and Medical Distributors: Renal Denervation Technology from St. Jude Medical...
Site Map | Renal Denervation (RDN World)
Any hope for renal denervation after SYMPLICITY HTN-3? - Mayo Clinic
Rapid Atrial Pacing in Cardiac Denervated Dogs Causes Sodium Retention and Not Natriuresis | Clinical Science | Portland Press
Contact Us | Renal Denervation (RDN World)
What is Disc Denervation? | Renova Spine
Patente US20050261672 - Systems and methods for selective denervation of heart dysrhythmias - Google Patentes
AboutBFS.com • View topic - Back from neuro, 10% scared, 30% unhappy.
US Patent Application for FEEDBACK SYSTEMS AND METHODS FOR RENAL DENERVATION UTILIZING BALLOON CATHETER Patent Application ...
Addressing key questions on renal denervation with the SPYRAL HTN global clinical trial programme
Inhibition of glycolysis in the denervated dog heart. | Circulation Research
Carotid Body Denervation Prevents the Development of Insulin Resistance and Hypertension Induced by Hypercaloric Diets |...
GW24-e1415 NE, Renin, Ang-II, ALD, ET-1, which one is the best indicator for renal denervation of treatment of resistant...
Expression of Caveolin-1 in Penile Cavernosal Tissue in a Denervated Animal Model after Treatment with Sildenafil Citrate
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DiVA - Søkeresultat
On the Auditory-Proprioception Substitution Hypothesis: Movement Sonification in Two Deafferented Subjects Learning to Write...
Plus it
Facet Denervation Charlottesville VA | Pain Management
AboutBFS.com • View topic - In hospital, really scared...
Sinoaortic contribution to ventilatory control in exercising dogs.
Study: Botox Could Prevent Spread of Gastric Cancer | Cancer Network
Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy | Acta Neuropathologica...
Terumo Granted CE Mark for Renal Sympathetic Denervation System
NESPS - Growth Hormone Ameliorates the Effects of Chronic Denervation Injury on Peripheral Nerve Regeneration and Improves...
Frontiers | Renal Denervation Promotes Atherosclerosis in Hypertensive Apolipoprotein E-Deficient Mice Infused with Angiotensin...
Specialist Cardiology | Renal Denervation
The localization and rate of disappearance of a synaptic vesicle antigen following denervation. :: MPG.PuRe
Treatment of facet syndrome with radiofrequency denervation: Costs for treatment #260607 in Germany | BookingHealth
Treatment of facet syndrome with radiofrequency denervation: Costs for treatment #183895 in Germany | BookingHealth
Krames Online - Understanding Radiofrequency Denervation
106 of the best peer-reviewed specialists in radiofrequency denervation |TopDoctors
Surgical cardiac denervation therapy for treatment of congenital ion c by John P. Costello, Jennifer K. Wilson et al.
Christian Daugaard Peters - Research outputs - Research - Aarhus University
Renal denervation in heart failure: Modulating the sympathetic nervous system
Renal Artery Intervention (including renal denervation) - ONA
Terms of Use - ReDy - Third-Generation Renal Denervation
Cholinergic denervation of the rat hippocampus by 192-lgG-saporin - Normandie Université
EuroIntervention: Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy.CBSET | CBSET
Please ask questions before Denervation - Surgical Therapies - Post Vasectomy Pain Forum
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Vincristine Local Delivery for Renal Artery Denervation | Springer for Research & Development
TCT: Renal Nerve Ablation Drops BP, Heart Rate | Medpage Today
PCR State-of-the-art lecture on The resurgence of renal denervation | EurekAlert! Science News
Ciliary ganglion
4) Denervation supersensitivity. Like any denervated muscle, the iris becomes supersensitive to its normal neurotransmitter (in ...
Substance P
Denervation supersensitivityEdit. When the innervation to substance P nerve terminals is lost, post-synaptic cells compensate ... This, ultimately, leads to a condition known as denervation supersensitivity as the post-synaptic nerves will become ...
Ross' syndrome
Ross AT (November 1958). "Progressive selective sudomotor denervation; a case with coexisting Adie's syndrome". Neurology. 8 ( ...
Urination
Denervation. When the afferent and efferent nerves are both destroyed, as they may be by tumors of the cauda equina or filum ... The hyperactive state in the former condition suggests the development of denervation hypersensitization even though the ...
Dysmenorrhea
Ramirez C, Donnellan N (2017). "Pelvic denervation procedures for dysmenorrhea". Curr Opin Obstet Gynecol. 29 (4): 225-230. doi ...
Salomon Z. Langer
The onset of denervation supersensitivity. Langer SZ, Trendelenburg U. J Pharmacol Exp Ther. 1966 Jan;151(1):73-86 ... His research was on the mechanisms involving denervation supersensitivity. with Ullrich Trendelenburg with whom he became ... course of the development of supersensitivity to various amines in the nictitating membrane of the pithed cat after denervation ...
Chronaxie
... "long-term denervation stage" of the rat model, i.e., denervation time longer than six months). In 3 out of 36 leg muscles, ... Chronaxie from 0.1-0.2 ms in innervated muscle changed to 0.5-1 ms within one to two days after denervation (i.e., after ... Chronaxie remained at this level up to 6 months postsciatectomy (Mid-term denervation stage in the rat model: from 2 to 6 ... Several studies have suggested that the function of denervation-induced myoD may be to prevent the muscle atrophy induced by ...
Low back pain
There is a lack of good quality evidence to support the use of radiofrequency denervation for pain relief. KT Tape has been ... Maas ET, Ostelo RW, Niemisto L, Jousimaa J, Hurri H, Malmivaara A, van Tulder MW (October 2015). "Radiofrequency denervation ...
Neck pain
Radiofrequency denervation may provide temporary relief for specific affected areas in the neck. Transcutaneous electrical ... Niemisto L, Kalso E, Malmivaara A, Seitsalo S, Hurri H (2003-01-20). "Radiofrequency denervation for neck and back pain. A ...
Reinnervation
Denervation Neuroregeneration Targeted reinnervation The Williams Dictionary of Biomaterials. Liverpool University Press. 1999 ...
Megavitamin-B6 syndrome
Needle electromyography studies generally reveal no signs of denervation. Megavitamin-B6 syndrome is characterized mainly by ...
Familial amyloid polyneuropathy
Occasionally, biopsy of skin, nerve, or muscle may be performed, which can show signs of denervation and amyloid deposition ... may show evidence of chronic denervation and reinnervation. Autonomic testing, including quantitative sweat testing, can reveal ...
Apraclonidine
The affected pupil is thus miotic and the pupillary dilator responds to denervation by increasing α1 receptors. Apraclonidine ... Koc F, Kansu T, Kavuncu S, Firat E (2006). "Topical apraclonidine testing discloses pupillary sympathetic denervation in ...
Linezolid
Chao CC, Sun HY, Chang YC, Hsieh ST (January 2008). "Painful neuropathy with skin denervation after prolonged use of linezolid ...
Paroxysmal sympathetic hyperactivity
The future may hold non-pharmacologic solutions such as renal sympathetic denervation. Perkes, Iain; Baguley, Ian J.; Nott, ... 13 (370). doi:10.1007/s11910-013-0370-3. Renal Sympathetic Denervation, From Wikipedia, the free encyclopedia12/7/2014. ...
Endoscopic thoracic sympathectomy
Goebel, F.-D.; Füessl, H.S. (1983). "Mönckeberg's sclerosis after sympathetic denervation in diabetic and non-diabetic subjects ... He has documented loss of thermoregulatory function, cardiac denervation, and loss of vasoconstriction. Recurrence of the ... Because of these difficulties, and because of disabling sequelae associated with sympathetic denervation, conventional or "open ... "Partial cardiac sympathetic denervation after bilateral thoracic sympathectomy in humans". Heart Rhythm. 2 (6): 602-9. doi: ...
Loin pain hematuria syndrome
Other treatments may include denervation, autotransplantation, renal neurectomy, or nephrectomy. Unfortunately symptoms often ... Pruritus management Maintenance therapy between pain exacerbations Implantable drug delivery system Surgical renal denervation ...
Trypanosoma cruzi
It is true that all inflammatory and non-inflammatory heart disease may display forms of parasympathetic denervation; this ... denervation presents in a descriptive fashion in Chagas' disease. It has also been indicated that the loss of parasympathetic ...
Rectal prolapse
This finding was shown to be absent in healthy subjects, and may be the cause of denervation-related atrophy of the external ... There may be denervation of striated musculature on the electromyogram. Increased nerve conduction periods (nerve damage), this ... This is most likely a denervation injury to the external anal sphincter. The assumed mechanism of fecal incontinence in rectal ...
ادرار کردن - ویکیپدیا، دانشنامهٔ آزاد
Denervation. When the afferent and efferent nerves are both destroyed, as they may be by tumors of the cauda equina or filum ... The hyperactive state in the former condition suggests the development of denervation hypersensitization even though the ...
Teres minor muscle
Additional electromyography is helpful to reveal any decelerated nerve conduction velocity, and thus denervation of the ... September 2006). ". Ultrasound findings of teres minor denervation in suspected quadrilateral space syndrome". J Clin ...
Diabetic cardiomyopathy
Therefore, the diabetic heart shows clear denervation as the pathology progresses. This denervation correlates with ... Other causes of denervation are ischemia from microvascular disease and thus appear following the development of ...
Rabaptin
... a novel neurite-outgrowth factor secreted by muscle after denervation". NeuroReport. 8 (16): 3649-3654. doi:10.1097/00001756- ...
Quadrilateral space syndrome
... is a rotator cuff denervation syndrome in which the axillary nerve is compressed at the ... Differential considerations include similar rotator cuff denervation syndromes such as Parsonage-Turner syndrome, and ... "Ultrasound findings of teres minor denervation in suspected quadrilateral space syndrome". Journal of Clinical Ultrasound. 34 ( ...
Catecholaminergic polymorphic ventricular tachycardia
Schwartz PJ, De Ferrari GM, Pugliese L (June 2017). "Cardiac sympathetic denervation 100years later: Jonnesco would have never ... or with surgical procedures including sympathetic denervation and implantation of a defibrillator. It is thought to affect as ... region of the sympathetic nervous system can be intentionally damaged in an operation known as cardiac sympathetic denervation ...
SNARE (protein)
Garcia A, Fulton JE (1996). "Cosmetic denervation of the muscles of facial expression with botulinum toxin. A dose-response ...
Jean-Pierre Changeux
Denervation increases a neurite-promoting activity in extracts of skeletal muscle. Nature. 1983 Apr 14;302(5909):609-11. Betz H ... During the 1970s, he tried to document this phenomenon, either by studying mutant animals or by experimental denervation. While ...
Adie syndrome
... pilocarpine may constrict the tonic pupil due to cholinergic denervation supersensitivity. A normal pupil will not constrict ... "Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie's Syndrome". Case Reports in Neurological Medicine ...
Lateral pectoral nerve
"The skin projection point of the neurovascular bundle (NVB) represents the denervation point (DP)." The NVB (thoracoacromial ... Titiz, Izzet; Ozel; Ozel; Toros; Marur; Yildirim; Erdogdu; Kara (19 August 2010). "Denervation Point for Neuromuscular Blockade ... may be the guide for local anesthetic applications in order to achieve pectoral muscle denervation. "Routine botulinum toxin ...
Familial amyloid neuropathy
July 2006). "Impact of liver transplantation on cardiac autonomic denervation in familial amyloid polyneuropathy". Medicine ( ...
Denervation - Wikipedia
Denervation is any loss of nerve supply regardless of the cause. If the nerves lost to denervation are part of the neuronal ... Denervation may be the result of nerve injury. The three main types of nerve injury are neurapraxia, axonotmesis and ... Denervation can have many harmful side effects such as increased risk of infection and tissue dysfunction.[2] ... This process of denervation is however different from post-polio syndrome in that it only involves upper and lower motor neuron ...
Renal (Kidney) Denervation for Uncontrolled Hypertension | HuffPost
Can renal denervation get you off medication? The studies so far have demonstrated blood pressure lowering in 90 percent or ... If your blood pressure is normal but you are on many medications, could renal denervation enable you to reduce or eliminate ... called renal denervation, involves interrupting nerves of the sympathetic nervous system that connect the brain and the kidneys ...
Denervation Surgery for Painful Joints
... Learn more about the Massachusetts General Hospital Division of Plastic and ... In order to determine if a patient is a good candidate for joint denervation surgery, local anesthetic is injected into the ... These procedures, known as joint denervations, are short in duration and can often be performed without general anesthesia. ... Patients undergoing a joint denervation procedure will have incisions placed at the locations of the different nerves supplying ...
SPYRAL HTN-OFF MED: Reopens Renal-Denervation Conversation
Denervation provided significant blood-pressure reductions for patients with stage 2 hypertension compared with a sham control ... Key to Denervation Response for Hypertension May Be in Carotid Body * FDA Promises Rigorous Review of New Renal Denervation ... Office readings showed SBP fell 10.0 mm Hg with denervation (P,0.001) and 2.3 mm Hg with sham (P=0.24), while DBP declined 5.3 ... Finally, drug testing of serum and urine confirmed that 94.3% of patients in the renal-denervation group and 92.7% in the sham ...
Denervation supersensitivity - Wikipedia
Denervation supersensitivity/Denervation hypersensitivity is the sharp increase of sensitivity of post-synaptic membranes to a ... S. Thesleff, L.C. Sellin, "Denervation supersensitivity", Trends in Neurosciences, Volume 3, Issue 5, May 1980, Pages 122-126 ... doi:10.1016/0166-2236(80)90046-6 S. Z. Langer, "Denervation Supersensitivity", in: Principles of Receptor Research Volume 2 of ... chemical transmitter after denervation. It is a compensatory change. ...
Renal Denervation: Blood Pressure Benefit in New Meta-analysis
A new meta-analysis of six sham-controlled studies of renal sympathetic denervation has shown a significant reduction in blood ... "This led to a loss of interest in the approach, but many of us held out hope that denervation could still be effective," he ... "After the SYMPLICITY HTN-3 trial, which failed to show a benefit of denervation, there was a loss of hope in this approach, but ... "This meta-analysis as a whole has shown a significant benefit of denervation over sham control, but when we looked at the more ...
Denervation symptoms, treatments & forums | PatientsLikeMe
Find the most comprehensive real-world symptom and treatment data on denervation at PatientsLikeMe. 2 patients with denervation ... and insomnia and use Gabapentin and Oxycodone-acetaminophen to treat their denervation and its symptoms. ... What is denervation?. Denervation refers to loss of nerve supply. It may be caused by a disease, injury, or intentional ... 0 evaluations from denervation patients report that they could not tell effectiveness of Oxycodone-acetaminophen for pain (0%) ...
'Y'tube cord denervation | Modern...
Translational medicine: the antihypertensive effect of renal denervation. - PubMed - NCBI
These research discoveries led to the development of a catheter-based procedure for renal denervation in human subjects. A ... Translational medicine: the antihypertensive effect of renal denervation.. DiBona GF1, Esler M. ... with hypertension resistant to conventional therapy has demonstrated that the procedure is safe and produces renal denervation ...
Renal denervation reduces recurrent AF after ablation | EurekAlert! Science News
Renal denervation reduces recurrent atrial fibrillation (AF) when performed with pulmonary vein isolation ablation in patients ... Renal denervation reduces recurrent AF after ablation. European Society of Cardiology. Journal. European Heart Journal. Meeting ... Renal sympathetic denervation (RD) is a new method that may be effective for controlling resistant hypertension by reducing the ... Renal sympathetic denervation was considered to have been achieved when the sudden increase of blood pressure (>15 mmHg from ...
Renal Denervation Flops in Pivotal Trial | Medpage Today
A major trial of Medtronics renal denervation system failed to meet its primary efficacy endpoint in a population of patients ... Jude Medicals renal denervation system -- EnligHTN-IV -- was stopped after enrolling fewer than 10 patients because of ... "I do not think this is the end of renal denervation," commented another study investigator Cindy Grines, MD, of Detroit Medical ... There is ample data that renal denervation reduces blood pressure in animal models and in smaller human trials, and there are ...
TCT: Renal Denervation No Better Than Sham | MedPage Today
... renal sympathetic denervation did not achieve a benefit in patients with mild but treatment-resistant hyperte ... TCT: Renal Denervation No Better Than Sham. by Peggy Peck, Editor-in-Chief, MedPage Today September 16, 2014 ... Source Reference: Desch, S et al "A randomized sham-controlled trial of renal sympathetic denervation in mild resistant ... WASHINGTON -- In a small study using ambulatory systolic pressure readings as an endpoint, renal sympathetic denervation (RSD) ...
Covidien Introduces OneShot Renal Denervation System
... as it will unveil its new OneShot renal denervation system at the ... latest in a line of companies entering the renal denervation ... Covidien Introduces OneShot Renal Denervation System. May 8th, 2012 Wouter Stomp Medicine, Radiology, Vascular Surgery ... Covidien is the latest in a line of companies entering the renal denervation business, as it will unveil its new OneShot renal ... If you are attending EuroPCR, it will be possible to watch two denervation procedures that will be transmitted live from ...
Renal Denervation in Diabetic Nephropathy - Full Text View - ClinicalTrials.gov
Experimental: Denervation + TMNS Patients are treated with the renal denervation procedure after randomization and are ... Procedure: Percutaneous renal denervation and TMNS Patients are treated with the renal denervation procedure after ... Renal Denervation in Diabetic Nephropathy (DERENEDIAB). The safety and scientific validity of this study is the responsibility ... Persu A, Sapoval M, Azizi M, Monge M, Danse E, Hammer F, Renkin J. Renal artery stenosis following renal denervation: a matter ...
Local Sympathetic Denervation in Painful Diabetic Neuropathy | Diabetes
Local Sympathetic Denervation in Painful Diabetic Neuropathy. Cees J. Tack, Petra J. van Gurp, Courtney Holmes, David S. ... Local Sympathetic Denervation in Painful Diabetic Neuropathy. Cees J. Tack, Petra J. van Gurp, Courtney Holmes, David S. ... Local Sympathetic Denervation in Painful Diabetic Neuropathy Message Subject (Your Name) has forwarded a page to you from ...
Bilateral Renal Artery Stenosis After Renal Denervation | Hypertension
Catheter-based renal denervation for resistant hypertension: 12-month results of the EnligHTN I first-in-human study using a ... Bilateral Renal Artery Stenosis After Renal Denervation. Fernando Jaén Águila, Juan Diego Mediavilla García, Eduardo Molina ... Renal artery stenosis, after renal denervation, with spontaneous resolution two year follow-up from procedure. Fernando Jaen ... Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3- year report of the Symplicity HTN-1 ...
Catheter-Based Renal Denervation for Resistant Hypertension | Hypertension
Catheter-Based Renal Denervation for Resistant Hypertension. Vasilios Papademetriou, Costas P. Tsioufis, Ajay Sinhal, Derek P. ... Catheter-Based Renal Denervation for Resistant Hypertension. Vasilios Papademetriou, Costas P. Tsioufis, Ajay Sinhal, Derek P. ... Catheter-Based Renal Denervation for Resistant Hypertension. 12-Month Results of the EnligHTN I First-in-Human Study Using a ... Renal denervation has emerged as a novel approach for the treatment of patients with drug-resistant hypertension. To date, only ...
Renal Denervation in Treatment Resistant Hypertension - Full Text View - ClinicalTrials.gov
Renal denervation Renal denervation using Symplicity Catheter system. Device: Renal denervation using Symplicity Catheter ... Renal Denervation in Treatment Resistant Hypertension. The safety and scientific validity of this study is the responsibility ... Impact of renal denervation on tissue Na(+) content in treatment-resistant hypertension. Clin Res Cardiol. 2018 Jan;107(1):42- ... Renal denervation in moderate treatment-resistant hypertension. J Am Coll Cardiol. 2013 Nov 12;62(20):1880-6. doi: 10.1016/j. ...
Renal Denervation Market Size Is Expected To Reach $ 3,153
... million by 2022, Rising at a Market Growth of 48.5% CAGR During the ... Key findings from the Renal Denervation Market:. • Based on product type, Symplicity Renal Denervation System sector is the ... The Vessix Renal Denervation System is expected to grow at its fastest rate, with an average annual growth rate of 57.6% from ... Renal Denervation Market Size Is Expected To Reach $ 3,153 million by 2022, Rising at a Market Growth of 48.5% CAGR During the ...
Otsuka Finds Paradise in Renal Denervation Market | MDDI Online
Holdings is set to acquire ReCor Medical for an undisclosed sum and follows Medtronic in a bid to get a renal denervation ... Otsuka Finds Paradise in Renal Denervation Market. Otsuka Holdings is set to acquire ReCor Medical for an undisclosed sum and ... Renal Denervation to treat hypertension has been somewhat elusive for medtech companies. While there was at one-point ... Any doubts about medtechs interest in renal denervation can now be put to rest. Otsuka Holdings is showing its very interested ...
Denervation suppresses gastric tumorigenesis | Science Translational Medicine
Denervation suppresses gastric tumorigenesis. By Chun-Mei Zhao, Yoku Hayakawa, Yosuke Kodama, Sureshkumar Muthupalani, ... Denervation suppresses gastric tumorigenesis. By Chun-Mei Zhao, Yoku Hayakawa, Yosuke Kodama, Sureshkumar Muthupalani, ... Denervation suppresses gastric tumorigenesis Message Subject. (Your Name) has forwarded a page to you from Science ...
Covidien to Exit OneShot Renal Denervation Program
Home , Covidien to Exit OneShot Renal Denervation Program. Covidien to Exit OneShot Renal Denervation Program. Covidien [1] plc ... Covidien plc has announced it will exit its OneShot Renal Denervation program. This voluntary action is primarily in response ... Over the next several weeks, the company will collaborate with physicians and the renal denervation community to ensure ... This voluntary action is primarily in response to slower than expected development of the renal denervation market. ...
Spironolactone versus renal nerve denervation for treatment... : Journal of Hypertension
7. Bhatt DL, Kandzari DE, ONeill WW, DAgostino R, Flack JM, Katzen BT, et al A controlled trial of renal denervation for ... 4. Symplicity HTNI, Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, et al Renal sympathetic denervation in patients ... Spironolactone versus renal nerve denervation for treatment of uncontrolled resistant hypertension Journal of Hypertension34(9 ... Spironolactone versus sympathetic renal denervation to treat true resistant hypertension: results from the DENERVHTA study - a ...
Vessix V2 Renal Denervation System Receives CE Mark Approval
Just two days after we reported on the design story behind the Vessix V2 renal denervation system,Vessix Vascular is now ... Vessix V2 Renal Denervation System Receives CE Mark Approval. May 2nd, 2012 Wouter Stomp Cardiology, Medicine, Radiology, ... Just two days after we reported on the design story behind the Vessix V2 renal denervation system,Vessix Vascular is now ... According to the company, the system is faster, easier to use and less painful for patients than any renal denervation system ...
Renal Denervation Helps To Bring Drug-Resistant Hypertension Under Control
Renal Denervation After Ablation Reduces Recurrent AF. Recurrent atrial fibrillation is reduced when renal denervation is ... In Advanced Heart Failure Renal Denervation Gives Better Outcomes Than Drugs According to research, renal denervation leads to ... The key implication of this study is that "renal denervation does lower arterial pressure when the denervation is complete," ... Confounding Factors Which Lead to Unexpected Results of Renal Denervation Trial. Analysis of renal denervation trial, ...
Hope for renal denervation revived with new sham-controlled trials
... but results from both studies linked renal denervation with significant reductions in BP on several assessments ... Two sham-controlled trials demonstrating the efficacy of renal denervation presented at EuroPCR have rekindled hope for the ... in that performing renal denervation with different intravascular techniques yields the same results. Renal denervation ... were randomly assigned to renal denervation with the Symplicity Spyral multielectrode renal denervation catheter (Medtronic) ...
Radiofrequency denervation for chronic low back pain | Cochrane
RF denervation used for disc pain produces conflicting results, with no effects for RF denervation compared with placebo over ... Radiofrequency denervation for chronic low back pain. Background Low back pain is a widespread problem that has major social ... When RF denervation is used for SI joint pain, low-quality evidence reveals no differences from placebo in effects on pain (MD ... Radiofrequency (RF) denervation, an invasive treatment for chronic low back pain (CLBP), is used most often for pain suspected ...
Cardiac sympathetic denervation for conventional treatment refractory arrhythmias.
PCR State-of-the-art lecture on 'The resurgence of renal denervation' | EurekAlert! Science News
Renal denervation (RDN) represents a device-based hypertension treatment intended to lower sympathetic activity. Only a few ... PCR State-of-the-art lecture on The resurgence of renal denervation Renal denervation significantly reduces blood pressure, ... A PCR State-of-the-Art lecture on "The resurgence of renal denervation" by Felix Mahfoud o Presentation during the #PCR e- ... Renal denervation (RDN) represents a device-based hypertension treatment intended to lower sympathetic activity. Only a few ...
HypertensionProcedureEffect of renalShown that renal denervationSystolicSymplicityEfficacyAblationClinicalGlobal renal denervationAtrophyResistantPercutaneousChronicField of renal denervationRationale for renal denervationUltrasound-based renal denervationTreatmentRenal denervation catheterCardiac sympathetic denervationMedtronic's2018Catheter is introducedPivotal trialProcess of denervationConsistent with denervationMedtronicBlood pressureOneShotNervesEffects of renalEffectiveness of renalDeviceInterventionEndpointMuscle denervation
Hypertension97
- In renal denervation, the procedure involves using radio frequency or ultrasound to remove sympathetic nerve supply to the wall of the kidney with the intention of reducing blood pressure and treating chronic hypertension . (wikipedia.org)
- An exciting and promising new procedure, which can help lower blood pressure in patients with resistant hypertension (hypertension not controlled by medication), is currently under study in 90 medical centers, including ours, throughout the U.S. The procedure, called renal denervation, involves interrupting nerves of the sympathetic nervous system that connect the brain and the kidneys as they course through the renal arteries (the arteries to the kidneys). (huffingtonpost.com)
- In SIMPLICITY HTN-3, patients had resistant hypertension (office SBP 180 mm Hg, with no diastolic cutoff), self-reported drug adherence to 5.1 medications prescribed at randomization, and received denervation of the main renal artery only performed by mostly inexperienced operators using a monoelectrode, sequential ablation system, Böhm said. (medscape.com)
- In contrast, SPYRAL HTN-OFF MED enrolled patients with an office SBP of 150 to less than 180 mm Hg, an office DBP of at least 90 mm Hg, and a mean 24-hour ambulatory SBP of 140 to less than 170 mm Hg and excluded those with isolated systolic hypertension because they've been shown to be hyporesponsive to renal denervation. (medscape.com)
- Invited discussant Prof Bryan William (University College London, UK) agreed that the data provide proof of concept that renal denervation lowered blood pressure in "about 75% of patients studied" but said by excluding those with isolated systolic hypertension it missed "the most common and most difficult-to-treat hypertension phenotype. (medscape.com)
- combined hypertension seems to respond better to denervation than isolated systolic hypertension. (medscape.com)
- These include minimization of participants with isolated systolic hypertension, performance of procedures by highly experienced operators, employment of more complete techniques of radiofrequency ablation, and use of other novel approaches such as endovascular ultrasound renal denervation. (medscape.com)
- A proof-of-principle study in patients with hypertension resistant to conventional therapy has demonstrated that the procedure is safe and produces renal denervation with sustained lowering of arterial pressure. (nih.gov)
- Barcelona, Spain - Sunday 31 August 2014: Renal denervation reduces recurrent atrial fibrillation (AF) when performed with pulmonary vein isolation ablation in patients with AF and hypertension, according to research presented at ESC Congress today by Dr Alexander Romanov from the Russian Federation. (eurekalert.org)
- Renal sympathetic denervation (RD) is a new method that may be effective for controlling resistant hypertension by reducing the hyperactivity of the renal sympathetic nerve. (eurekalert.org)
- A major trial of Medtronic's renal denervation system failed to meet its primary efficacy endpoint in a population of patients with treatment-resistant hypertension, the company said Thursday. (medpagetoday.com)
- WASHINGTON -- In a small study using ambulatory systolic pressure readings as an endpoint, renal sympathetic denervation (RSD) did not achieve a benefit in patients with mild but treatment-resistant hypertension. (medpagetoday.com)
- Desch, S et al "A randomized sham-controlled trial of renal sympathetic denervation in mild resistant hypertension" TCT 2014. (medpagetoday.com)
- Like all other recently introduced denervation systems, it is intended to treat patients with hypertension who are not responsive to traditional medical therapy. (medgadget.com)
- Renal stenosis after sympathetic denervation of the renal arteries in hypertensive patients is a very unusual complication, but it sometimes appears together with hypertension recurrence. (ahajournals.org)
- Renal denervation has emerged as a novel approach for the treatment of patients with drug-resistant hypertension. (ahajournals.org)
- Tokyo-based Otsuka's big play comes just a few short days after MD+DI reported that FDA gave Palo Alto, CA-based ReCor Medical the green light to run a pivotal study of its ultrasound-based renal denervation system for the treatment of hypertension. (mddionline.com)
- Renal Denervation to treat hypertension has been somewhat elusive for medtech companies. (mddionline.com)
- Just two days after we reported on the design story behind the Vessix V2 renal denervation system, Vessix Vascular is now announcing it has received European CE Mark approval for its percutaneous radiofrequency balloon catheter technology for the treatment of hypertension. (medgadget.com)
- Now, researchers report in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology that renal denervation-a procedure that disrupts the nerves in the kidneys and prevents them from relaying signals-can treat hypertension, including resistant hypertension, when the nerves are completely blocked. (medindia.net)
- Renal denervation lowers blood pressure when performed at either the early or late stages of hypertension. (medindia.net)
- Recurrent atrial fibrillation is reduced when renal denervation is performed with pulmonary vein isolation ablation in patients with AF and hypertension, suggests a research. (medindia.net)
- Reducing blood pressure in patients with resistant hypertension using renal denervation seems to be more successful when it includes accessory renal arteries, suggests a study. (medindia.net)
- Two sham-controlled trials demonstrating the efficacy of renal denervation presented at EuroPCR have rekindled hope for the technology as a treatment for hypertension. (healio.com)
- Renal denervation as a treatment for resistant hypertension experienced a setback in 2014 with the failure of the SYMPLICITY-HTN 3 trial . (healio.com)
- In the SPYRAL HTN-ON MED trial, researchers sought to evaluate the effect of renal denervation therapy on BP in the presence of commonly prescribed antihypertensive medications "in a context considered more representative of clinical practice - integrating both device therapies and pharmacotherapies for the treatment of uncontrolled hypertension," David E. Kandzari, MD, from the Piedmont Heart Institute in Atlanta, said. (healio.com)
- These patients with uncontrolled hypertension, defined as systolic BP between 150 mm Hg and 180 mm Hg while taking one to three antihypertensive medications, were randomly assigned to renal denervation with the Symplicity Spyral multielectrode renal denervation catheter (Medtronic) and the Symplicity G3 renal denervation RF generator (Medtronic) or sham procedure consisting of a renal angiogram. (healio.com)
- Renal denervation (RDN) represents a device-based hypertension treatment intended to lower sympathetic activity. (eurekalert.org)
- The study is intended to evaluate safety and efficacy of multi-electrode radiofrequency renal denervation in patients with uncontrolled hypertension. (clinicaltrials.gov)
- We are now looking back on 10 years of experience with catheter-based renal sympathetic denervation for treatment of human hypertension and it has been a long and winding road. (lww.com)
- Renal denervation (RDN), as a treatment for hypertension, initially gained traction early this century. (bmj.com)
- 4578 ) said today that it plans to acquire the remaining stake it doesn't already own in ReCor Medical and the renal denervation device it's developing to treat hypertension. (massdevice.com)
- ReCor's statistically significant clinical results in the Solo trial are convincing biological proof that renal denervation with ReCor's ultrasound-based system is effective in reducing blood pressure in patients with hypertension. (massdevice.com)
- We are excited to commercialize this technology, which has the potential to become one of the great technological advancements in hypertension treatment together with the ReCor team," Kazumichi Kobayashi, global renal denervation project leader, said in a press release. (massdevice.com)
- When medication fails and patients appear to suffer from drug resistant hypertension, a renal sympathetic denervation is a possible treatment. (rug.nl)
- Renal artery denervation is a new minimally invasive radiological procedure for the treatment of hypertension (high blood pressure) which is resistant to combination drug therapy. (bmihealthcare.co.uk)
- Renal denervation has been developed in order to lower systolic blood pressure in resistant hypertension by a reduction in renal afferent and efferent sympathetic nerve activity. (ovid.com)
- An international, multi-center, prospective, randomized, controlled study of the safety and effectiveness of renal denervation in patients with uncontrolled hypertension. (clinicaltrials.gov)
- Cochrane corner: renal denervation for resistant hypertension-a broken promise? (bmj.com)
- Here we report on the effects of renal denervation on hemodynamic, metabolic, and renal parameters in two obese PCOS patients with hypertension. (nih.gov)
- This book examines renal pathophysiology and the rationale for renal denervation (RDN), a minimally invasive, endovascular catheter based procedure using radiofrequency ablation for the treatment of resistant hypertension, a leading cause of morbidity and mortality in western civilization. (springer.com)
- 1.1 Current evidence on percutaneous transluminal radiofrequency sympathetic denervation of the renal artery for resistant hypertension is from limited numbers of patients, but there is evidence of efficacy in the short and medium term. (nice.org.uk)
- 1.2 Clinicians wishing to undertake percutaneous transluminal radiofrequency sympathetic denervation of the renal artery for resistant hypertension should take the following actions. (nice.org.uk)
- While electrical stimulation of baroreceptors and other interventional treatments of hypertension are already "knocking at the door", the premature and uncontrolled dissemination of renal denervation should remain an example of what should not be done, and trigger radical changes in evaluation processes of new devices by national and European health authorities. (springer.com)
- In 2009, Krum and colleagues [ 1 ] published a non-randomised proof-of-concept study, testing percutaneous radiofrequency catheter-based renal sympathetic denervation (RDN) as a novel treatment of resistant hypertension in a cohort of 45 patients. (springer.com)
- There is convincing evidence from studies like the Enlightn I trial linking renal denervation to improved blood pressure in patients who have drug-resistant hypertension,' principal investigator Dr. Johannes Brachmann said in prepared remarks. (massdevice.com)
- In May 2012 St. Jude landed CE Mark approval and announced commercial launch for its Enlightn renal denervation system as a treatment for hypertension. (massdevice.com)
- Renal artery denervation for patients with uncontrolled hypertension in the absence of renal artery stenosis. (oncologynurseadvisor.com)
- Renal artery denervation is typically contraindicated in patients with renal artery abnormalities, such as renal artery stenosis, or any known secondary cause of hypertension including a glomerular filtration rate of 45 mL/min. (oncologynurseadvisor.com)
- Sympathetic denervation of the renal artery is considered if hypertension fails to respond adequately to these measures. (nice.org.uk)
- An example of criteria used to select patients for the procedure is given in the Joint UK Societies' Consensus Statement on Renal Denervation for Resistant Hypertension. (nice.org.uk)
- 2.2.1 Percutaneous transluminal radiofrequency sympathetic denervation of the renal artery for resistant hypertension aims to disrupt neurogenic reflexes involved in blood pressure control. (nice.org.uk)
- Growing incidences of hypertension, changing lifestyle, and enduring effect of renal denervation procedure are the key factors driving market.Increasing cases of uncontrolled and drug-resistant hypertension are expected to fuel the demand for renal denervation. (medindia.net)
- Furthermore, hypertension is responsible for at least 51% of deaths due to stroke and 45% of deaths due to heart disease.The renal denervation market in developed economies, such as U.K., France , and Italy , is comparatively mature owing to the presence of key companies in these countries and high demand for such products. (medindia.net)
- Renal denervation fell short of primary and secondary efficacy goals in patients with severe resistant hypertension but did meet the primary safety endpoints, according to keenly awaited data from SYMPLICITY HTN-3 presented at the American College of Cardiology's 63rd Annual Scientific Session. (medicalxpress.com)
- This pivotal trial is the largest study conducted of renal artery denervation as a treatment for resistant hypertension and the most rigorously designed, including blinding and a sham treatment in the control arm. (medicalxpress.com)
- Although renal denervation is in clinical use for uncontrolled hypertension in more than 80 countries, it is still considered an experimental approach in the United States. (medicalxpress.com)
- This study randomly assigned 535 patients with resistant hypertension and systolic blood pressure of 160 mmHg or higher to renal denervation or angiography alone. (medicalxpress.com)
- We saw no added treatment benefit of renal denervation for patients with severe resistant hypertension who were closely monitored and optimally treated with medications. (medicalxpress.com)
- Renal Denervation (RDN) also known as Renal Sympathetic Denervation (RNSD) is a minimally invasive, catheter-based endovascular procedure that utilizes radiofrequency energy or ultrasound energy to ablate nerves in the walls of the renal artery, causing a reduction in blood pressure in patients with resistant hypertension. (reportbuyer.com)
- HealthDay News) - For patients with treatment-resistant hypertension and chronic kidney disease, renal denervation (RDN) reduces blood pressure (BP) and can slow renal function decline, according to a study presented at the American Heart Association's 2013 Scientific Sessions, held from Nov. 16-19 in Dallas. (empr.com)
- Sympathetic denervation and neuromodulation techniques still provide an exciting opportunity for the treatment of resistant hypertension and of a variety of other diseases. (businesswire.com)
- LEXINGTON, Mass.--( BUSINESS WIRE )--Though a large body of scientific research has convincingly demonstrated the link between sympathetic activity and drug-resistant hypertension, catheter-based renal denervation has been confounded by unreliable efficacy in large patient populations. (businesswire.com)
- Tokyo ― Terumo Corporation (TSE: 4543 Section 1) announced CE marking for the commercial sale of the Iberis™ Renal Sympathetic Denervation System, which the company has consigned product development to Shanghai AngioCare Medical Technology Co., Ltd. (hereinafter 'AngioCare') (Representative: Philip Wang), a Chinese company in renal sympathetic denervation technology for resistant hypertension treatment. (terumo-europe.com)
- EMAILWIRE.COM , January 11, 2017 ) Renal denervation is a catheter-based minimally-invasive ablation procedure that helps reduce systolic blood pressure in individuals with drug-resistant hypertension. (emailwire.com)
- As a result, interest in renal denervation as a treatment for resistant hypertension has waned. (bmj.com)
- In the DENERHTN trial, Azizi and colleagues assessed the incremental benefit of adding renal denervation to standardized stepped-care antihypertensive treatment (SSAHT) for patients with resistant hypertension in an open-label, randomized-controlled trial with blinded endpoint evaluation. (bmj.com)
- After four weeks of a standardized anti-hypertensive regimen to confirm resistant hypertension, patients were randomized to renal denervation in addition to SSAHT versus SSAHT alone. (bmj.com)
- When added to a stepped antihypertensive treatment strategy, renal denervation led to a greater decrease in ambulatory blood pressure for patients with resistant hypertension than medications alone. (bmj.com)
- These findings may reinvigorate interest in renal denervation and point to the need for additional trials to fully inform the role of this procedure in hypertension care. (bmj.com)
- Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (denerhtn): A multicentre, open-label, randomised controlled trial. (bmj.com)
- Therefore, renal denervation never became an accepted method of treating hypertension. (managedcaremag.com)
- The Joint UK Societies' consensus statement on renal denervation for resistant hypertension is now published on line (link below). (renal.org)
- Essentially it says that although the Joint UK Societies' group recognises that there were a number of flaws in the design and conduct of the Symplicity HTN-3 study, it does not recommend the use of renal denervation for treatment of resistant hypertension in routine clinical practice. (renal.org)
- The radical sympathectomy and percutaneous catheter-based renal denervation (RDN) are two techniques proposed to treat life-threatening resistant hypertension. (embs.org)
- The REQUIRE STUDY is a multi-center, randomized, double-blind, sham-controlled study, which aims to confirm the efficacy and safety of PRDS-001 (ReCor Medical Inc. Paradise in Europe) for renal denervation therapy in patients with treatment resistance hypertension, in comparison with the sham procedure. (centerwatch.com)
- As many patients with uncontrolled hypertension struggle to adhere to lifelong drug therapy for a variety of reasons and may look to other options that complement traditional treatments, we believe this advance could help clinicians work with patients to better manage their high blood pressure," said Dave Moeller, vice president and general manager of the Coronary and Renal Denervation business, which is part of the Cardiac and Vascular Group at Medtronic. (globenewswire.com)
- Medtronic is committed to the field of renal denervation and in addressing the unmet need in hypertension management globally, and we look forward to seeing more insights from our industry-leading SPYRAL HTN clinical program as we realize the full potential of the therapy. (globenewswire.com)
- Among patients with resistant hypertension, it is very important to select patients most likely to benefit from renal sympathetic denervation, because they represent a very mixed group of diagnoses. (signavitae.com)
- Renal sympathetic denervation has been demonstrated as an antihypertensive treatment in resistant hypertension patients with additional positive effects on glucose metabolism and insulin sensitivity in type 2 diabetes. (signavitae.com)
- We report a single centre report of renal sympathetic denervation effects in a small cohort of patients with resistant hypertension and stage 2-3 chronic kidney disease. (signavitae.com)
- Renal sympathetic denervation (RDN) has been demonstrated as an antihypertensive treatment in resistant hypertension patients, and triggers additional positive effects on glucose metabolism and insulin sensitivity in type 2 diabetes. (signavitae.com)
- SAN FRANCISCO-The verdict is in for renal denervation for treatment-resistant hypertension: According to results from major trials at TCT, the therapy produces safe, efficient, and persistent reductions in blood pressure. (acc.org)
- While the evidence gap on renal denervation for treatment-resistant hypertension is closing, the scope of possibilities for treating other conditions is growing. (acc.org)
- According to Justin E. Davies, MBBS, PhD, early experience in small trials has shown that renal denervation improves cardiac function in patients with resistant hypertension, without introducing new safety events. (acc.org)
- Despite meeting primary safety endpoints, SYMPLICITY HTN-3 - the pivotal U.S. trial examining renal denervation for treatment-resistant hypertension - has fallen short of its secondary efficacy goals, and failed to reach its primary efficacy endpoint as announced earlier this year by the study's sponsor. (acc.org)
- The largest study of its kind, and the most rigorously designed - including blinding and a sham treatment in the control arm - SYMPLICITY HTN-3 sought to evaluate the safety and effectiveness of renal denervation with the investigational Symplicity renal denervation system in patients with treatment-resistant hypertension and systolic blood pressure higher than 160 mmHg. (acc.org)
- to confirm previously reported benefits of renal denervation in patients with resistant hypertension. (acc.org)
- Should this statement indeed hold true, we will have to come to grips with two facts: the SYMPLICITY studies merely document the natural history of resistant hypertension in clinical trials, and the time has come to turn the page on renal denervation for hypertension but by all means, let's not close the book. (acc.org)
- Ocular sympathetic denervation associated with ocular hypertension: a case report. (bmj.com)
- A case of ocular sympathetic denervation associated with ocular hypertension is reported. (bmj.com)
- Following the spectacular crash and burn of the SYMPLICITY HTN-3 trial at the American College of Cardiology (ACC) meeting two weeks ago, the future of renal denervation (RDN) - the once highly promising catheter technology that many thought would cure resistant hypertension - appears in doubt. (jwatch.org)
- Negative Findings on Renal Denervation for Hypertension: Sweet SYMPLICITY? (jwatch.org)
- This week's topics include hospital variation in noninvasive cardiac imaging, percutaneous renal denervation in patients with treatment-resistant hypertension, and more. (jwatch.org)
- Parasympathetic denervation hypersensitivity of the iris in ocular hypertension. (arvojournals.org)
- Renal denervation was not superior to intensified medical treatment in patients with validated true resistant hypertension, in the 12-month results from the PRAGUE-15 trial. (eshonline.org)
- However, these results do not support renal denervation as being more effective than intensified medical treatment with spironolactone for the treatment of true resistant hypertension. (eshonline.org)
Procedure24
- In addition to peripheral nerve injury , denervation is used as a medical procedure for various benefits resulting from eliminating nerve supply to a specific area of the body. (wikipedia.org)
- [6] However, renal denervation is used less frequently in recent years due to new evidence suggesting that blood pressure is not significantly reduced after the procedure and there are even recommendations against using the procedure since there has been little proof to show that renal denervation leads to reduced blood pressure. (wikipedia.org)
- In order to determine if a patient is a good candidate for joint denervation surgery, local anesthetic is injected into the nerves supplying sensation to the painful joint (a procedure called a nerve block). (massgeneral.org)
- Patients undergoing a joint denervation procedure will have incisions placed at the locations of the different nerves supplying their painful joint. (massgeneral.org)
- These research discoveries led to the development of a catheter-based procedure for renal denervation in human subjects. (nih.gov)
- Although the company didn't release specific numbers from the pivotal SYMPLICITY HTN-3 trial, the announcement bears out suggestions that renal denervation was turning out to be no better than a sham procedure at lowering office systolic blood pressure among patients who continued taking their anti-hypertensives over a 6-month period. (medpagetoday.com)
- Renal artery stenosis, after renal denervation, with spontaneous resolution two year follow-up from procedure. (ahajournals.org)
- While there was at one-point heightened interest in the procedure, medtech firms abandoned the field when Medtronic revealed disappointing results in its renal denervation trial in January of 2014. (mddionline.com)
- Rapid RF treatment time greatly increases the efficiency of the denervation procedure and additional safety benefits to the clinician conducting the procedure and the patient in terms of less use of contrast dye and lower exposure to radiation. (medgadget.com)
- Most clinical studies have shown that renal denervation can lower high blood pressure in drug-resistant cases, but a number have shown the procedure to be ineffective. (medindia.net)
- Clearly, it is also important to develop a method to assess the completeness of denervation at the time of the procedure. (medindia.net)
- Analysis of renal denervation trial, SYMPLICITY HTN-3, shows that the results may be affected by the way the procedure was performed and changes in patients' medications and drug adherence. (medindia.net)
- Further, with assessment over a 24-hour period, renal denervation, as compared with sham procedure, was associated with a persistent consistent reduction in BP at all time intervals. (healio.com)
- This invasive procedure is called radiofrequency denervation. (cochrane.org)
- Radiofrequency denervation is an invasive procedure that can cause a variety of complications. (cochrane.org)
- Unlike surgical sympathectomy, renal denervation is a minimally invasive, endovascular catheter-based procedure performed via femoral access. (bmj.com)
- The modest blood pressure benefit directly assignable to renal denervation should be balanced with unresolved safety issues, such as potentially increased risk of renal artery stenosis after the procedure (more than ten cases reported up to now, most of them in 2014), unclear long-term impact on renal function and lack of morbidity-mortality data. (springer.com)
- Moreover, increasing clinical trials to validate clinical efficacy of renal denervation and cost effectiveness of the procedure over conventional surgeries are expected to offer high growth opportunities for players active in the global renal denervation systems market. (marketsandmarkets.com)
- It considered sympathetic denervation of the renal artery to be a promising procedure, which might offer benefit to many patients, but a larger evidence base of well-designed trials is required. (nice.org.uk)
- During the renal denervation procedure with the Symplicity device used in this trial, a catheter is threaded through arteries to deliver radiofrequency energy that inactivates kidney nerves, interrupting electrical signals to and from the kidney, an organ that performs a major role in regulating blood pressure. (medicalxpress.com)
- However, sympathectomy has been abandoned due to the procedure being too invasive, and RDN resulted in variation in blood pressure reduction between patients due to suboptimal denervation. (embs.org)
- These effects persisted for at least several months after PADN, suggesting that the procedure produces a permanent sympathetic denervation of the pulmonary arterial tree. (onlinejacc.org)
- The global, sham-controlled study evaluated 331 patients-166 of whom were randomized to renal denervation (RDN), a minimally invasive procedure intended to regulate overactivity of nerves that lead to and from the kidney. (globenewswire.com)
- The objective of this study is to evaluate the early results of this operation combined with a selective intra-abdominal denervation in diabetic patients with BMI below 35.The procedure was performed in 33 patients. (sages.org)
Effect of renal4
- Translational medicine: the antihypertensive effect of renal denervation. (nih.gov)
- To determine the effect of renal denervation (RDN) on the severity of atherosclerosis and aortic aneurysm in hypertensive mice. (frontiersin.org)
- The prospective, open, randomized, trial was conducted at 3 centers in Prague to evaluate the effect of renal denervation with the Symplicity catheters compared with intensified antihypertensive therapy including spironolactone 25 mg on 24-hour blood pressure. (eshonline.org)
- Introduction: The effect of renal sympathetic denervation (RDN) on neurohormonal responses is largely unknown. (eur.nl)
Shown that renal denervation1
- Initial studies have shown that renal denervation is able to reduce not only blood pressure but also heart rate, and is associated with a reduction in myocardial hypertrophy, improved glucose tolerance, and ameliorated microalbuminuria. (ovid.com)
Systolic9
- Compared with sham, denervation was also associated with a significant decrease in daytime ambulatory systolic blood pressure, office systolic blood pressure, 24-hour ambulatory diastolic blood pressure, daytime ambulatory diastolic blood pressure, and office diastolic blood pressure. (medscape.com)
- In these patients, renal denervation may reduce systolic blood pressure by approximately 20 percent, thereby greatly reducing the risk of stroke and cardiovascular disease. (medgadget.com)
- Additionally, ambulatory BP assessment over 24 hours at baseline, 3 months and 6 months showed a trajectory of progressive decline in BP for patients receiving renal denervation therapy for both systolic and diastolic BP measures, Kandzari noted. (healio.com)
- The use of a sound methodology, including randomisation and blinded endpoint assessment was enough to see the typical 25-30 mmHg systolic blood pressure decrease observed after renal denervation melt down to less than 3 mmHg, the rest being likely explained by Hawthorne and placebo effects, attenuation of white coat effect, regression to the mean and other physician and patient-related biases. (springer.com)
- The new trial builds on the success of Enlightn I, in which researchers concluded that treatment with St. Jude's renal denervation system produced significant and sustained reduction in systolic blood pressure. (massdevice.com)
- Renal denervation failed to achieve the primary efficacy endpoint of a decrease in systolic blood pressure measured in the doctor's office from baseline to six months or the powered secondary efficacy endpoint of decrease in average 24-hour levels by ambulatory blood pressure monitoring, which provides more reliable readings. (medicalxpress.com)
- Although both study groups showed a statistically significant decrease at six months compared with baseline (-14.1 mmHg for renal denervation compared to -11.7 mmHg for the sham treatment control), the difference of -2.29 mmHg in office systolic blood pressure between the two arms was not significant. (medicalxpress.com)
- Despite large reductions in blood pressure seen in early studies of renal denervation, the SYMPLICITY HTN-3 randomized trial failed to show a reduction in systolic blood pressure with renal denervation when compared to medical therapy alone. (bmj.com)
- At 12 months, a significant reduction from baseline in systolic blood pressure (SBP) measured in the office was found within the renal denervation group and within the medical treatment group, but there was no between-group difference for this reduction ( Figure 1 ). (eshonline.org)
Symplicity13
- Unfortunately, in the largest and most rigorous trial to be done - SYMPLICITY HTN-3 - there was no difference between medical therapy and denervation. (medscape.com)
- Other studies -- including the Global SYMPLICITY post-market surveillance registry and studies looking at renal denervation for other conditions -- will continue. (medpagetoday.com)
- Bilateral renal denervation will be performed using the Symplicity Catheter - a percutaneous system that delivers radiofrequency (RF) energy through the luminal surface of the renal artery. (clinicaltrials.gov)
- The Symplicity Renal Denervation System is estimated to continue to generate the highest revenue for the entire forecast period as the number of product approvals worldwide increases. (openpr.com)
- Based on product type, Symplicity Renal Denervation System sector is the largest and Vessix Renal Denervation System is expected to grow at the fastest rate. (openpr.com)
- Whitbourn R, Harding SA, Walton A. Symplicity multi-electrode radiofrequency renal denervation system feasibility study. (clinicaltrials.gov)
- MDT ) said it's closed the 1st phase of a feasibility trial for its next-generation Symplicity renal denervation device for high blood pressure. (mdtmag.com)
- After three years of excessive confidence, overoptimistic expectations and performance of 15 to 20,000 renal denervation procedures in Europe, the failure of a single well-designed US trial-Symplicity HTN-3-to meet its primary efficacy endpoint has cast doubt on renal denervation as a whole. (springer.com)
- St. Jude last year touted study results finding that its Enlightn renal denervation system lowered high blood pressure faster than Medtronic's Symplicity. (massdevice.com)
- There are already four radiofrequency devices that have received a CE mark for catheter-delivered renal denervation in Europe: St. Jude Medical's EnligHTN, Medtronic's Symplicity, Covidien's OneShot and Vessix Vascular's Vessix 2. (managedcaremag.com)
- In response to the announcement of the Symplicity HTN-3 study results earlier this year, the Joint UK Societies' issued an initial response suggesting a temporary moratorium on the use of renal denervation in the UK until further advice (RA eNews February 2014). (renal.org)
- Along with the Global Symplicity Registry, conducted outside the United States, Medtronic's renal denervation program includes more than 4,000 patients, studied in the presence and absence of medication, and in patients with high baseline cardiovascular risk. (globenewswire.com)
- SYMPLICITY HTN-3, the eagerly awaited first rigorous test of renal denervation, shows that the real effect of the novel blood-pressure-lowering technology is dramatically lower than earlier expectations, which had been fueled by data from previous uncontrolled trials. (jwatch.org)
Efficacy5
- The study was not powered for statistical significance but "provides biologic proof of principle for the efficacy of renal denervation" and will inform the design of a larger pivotal trial, co-primary investigator Dr Michael Böhm (University Hospital of Saarland, Homburg/Saar, Germany) reported here at the European Society of Cardiology (ESC) Congress 2017 . (medscape.com)
- Altogether, the present study affirms the safety and efficacy of renal denervation for blood pressure reduction and highlights the importance of incorporating the previously described modifications in trial design," the authors write. (medscape.com)
- The 433-patient SPYRAL HTN trial is part of the broader SPYRAL HTN Global Clinical Program, a multi-phased clinical study strategy aimed to establish the safety and efficacy of renal denervation to lower blood pressure. (mddionline.com)
- These data increase CBSET's insight into the connection between target anatomy and patient efficacy post-renal denervation by single and multiple RF electrode catheters. (businesswire.com)
- Nonetheless, these results may provide some added insights into early procedural efficacy and durability after renal denervation. (brightsurf.com)
Ablation8
- Identification of the pathogenetic mechanisms involved in the fall in blood pressure after renal denervation may help to identify those hypertensive patients that profit most from renal nerve ablation in terms of blood pressure reduction. (clinicaltrials.gov)
- ReCor Medical was created in 2009 by Sofinnova Partners and has developed the Paradise System, an ultrasound ablation system for renal denervation. (mddionline.com)
- Methods and apparatus are provided for selective denervation of conduction pathways in the heart for the treatment of dysrhythmias, including one or more ablation or electroporation catheters having electrodes for stimulating, targeting, and ablating fat pad tissue and other cardiac tissue to selectively. (google.es)
- All measurements were repeated 3 months after bilateral renal denervation achieved via percutaneous endovascular radiofrequency ablation. (nih.gov)
- Aims To evaluate 'targeted lung denervation' (TLD), a novel bronchoscopic therapy based on ablation of parasympathetic pulmonary nerves surrounding the main bronchi, as a potential therapy for COPD. (bmj.com)
- Dr. Rami Tzafriri , Principal Scientist and computational modeling expert at CBSET, will present: "Renal Norepinephrine Reduction Following Radiofrequency Renal Denervation Correlates with Extent of Nerve Ablation: Roles of Ablation Areas, Anatomy, and Number of Treatments", on Saturday, Sept. 13, 2:40 p.m. (businesswire.com)
- Effective December 10, 2019 , Horizon BCBSNJ will change the way we consider certain professional claims based on the implementation of our new¹ medical policy, Radiofrequency Joint Ablation/Denervation. (horizonblue.com)
- Little is known about the extent of vagal denervation and recovery of parasympathetic function after ablation.This study examined electrophysiological changes in parasympathetic response to the atria after surgical ablation. (ahajournals.org)
Clinical15
- So we can't become too excited about these data referable to clinical application, but what we can do is accept the fact that these data initiate the conversations again about renal denervation. (medscape.com)
- Steffen Desch, MD, of the University of Leipzig Heart Center, who reported the findings at a late-breaking clinical trial session at the Transcatheter Cardiovascular Therapeutics meeting here, told MedPage Today that renal sympathetic denervation "may have an application in science, but not in the clinic except for the very rare patient. (medpagetoday.com)
- Over the next several weeks, the company will collaborate with physicians and the renal denervation community to ensure existing OneShot patients are informed and the currently enrolling clinical trials are transitioned appropriately. (mdtmag.com)
- The patented RF balloon catheter connects to a proprietary bipolar RF generator specifically designed and optimized for the renal denervation clinical application. (medgadget.com)
- This observation is contrary to clinical trials in humans that supported that the effectiveness of renal denervation depended on blood pressure level, says John Osborn of the University of Minnesota and lead investigator of the study. (medindia.net)
- There were no major adverse events at 6 months in the overall study population, but more specifically, in the renal denervation cohort, there were no major clinical events, including no new renal artery stenosis or worsening renal function and no major bleeding or vascular complications, Kandzari reported. (healio.com)
- Renal nerve denervation (RND) entered clinical trials backed by strong preclinical evidence alongside decades of clinical research confirming the strong contribution of the adrenergic system to the hypertensive continuum. (springer.com)
- We look forward to moving forward with our clinical evaluation of this next-generation system that aims to augment our portfolio by offering more sophisticated features that should benefit both physicians and patients,' Medtronic's president of coronary & renal denervation Sean Salmon said in prepared remarks. (mdtmag.com)
- Accordingly, there is no doubt that renal denervation is not ready for clinical use. (springer.com)
- Medtronic is also the closest to winning FDA approval for renal denervation, with U.S. clinical trials approved in the summer of 2011 . (massdevice.com)
- Here we propose a minimally invasive Laparoscopic Denervation System (LDS) to serve this unmet clinical need. (embs.org)
- Medtronic and Boston Scientific have announced plans to start phase 2 clinical trials this year for their updated renal denervation catheters. (jwatch.org)
- 2 Muscle denervation is a major clinical feature of MND and results in fluid shifts detectable as altered T2 signal characteristics 3 that, in contrast to clinical assessments, are independent of participant's effort and premorbid abilities. (bmj.com)
- Although impulsive choices are exacerbated in PD patients with ICDs under DRTs, some clinical and preclinical studies suggest that the DA denervation of the dorsal striatum induced by the neurodegenerative process as well as a pre-existing high impulsivity trait, may both contribute to the emergence of ICDs in PD. (frontiersin.org)
- The demonstration of cholinergic denervation with an anatomy that fits the clinical picture suggests that cholinergic treatment is justified in patients with PPA who have positive AD biomarkers. (neurology.org)
Global renal denervation6
- The global renal denervation systems market is poised to witness a steady growth during the forecast period. (marketsandmarkets.com)
- Boston Scientific Corporation, St. Jude Medical, Inc., ReCor Medical, Inc., Cordis Corporation, and Terumo Corporation are some of the key players present in global renal denervation systems market. (marketsandmarkets.com)
- global renal denervation market size is expected to reach USD 1.03 billion by 2026, according to a new report by the Grand View Research, Inc. The market is estimated to register a CAGR of 43.2% during the forecast period. (medindia.net)
- Publisher's analysts forecast the global renal denervation market to grow at a CAGR of 11.82% during the period 2016-2020. (emailwire.com)
- The report covers the present scenario and the growth prospects of the global renal denervation market for 2016-2020. (emailwire.com)
- Publisher's report, Global Renal Denervation Market 2016-2020, has been prepared based on an in-depth market analysis with inputs from industry experts. (emailwire.com)
Atrophy8
- This magnified image of type 2 muscle fibers shows denervation atrophy occurring at the white spaces at the top left and bottom center of the image. (wikipedia.org)
- The motor unit areas soon increase to a point where reinnervation is no longer possible causing an uncompensated denervation of motor units which leads to muscle atrophy and loss of muscular strength. (wikipedia.org)
- Following denervation, muscular atrophy and degeneration occurs within affected skeletal muscle tissue. (wikipedia.org)
- The CT findings of denervation atrophy due to CN VII dysfunction have been reported. (ajnr.org)
- Because blocking myostatin in an adult wild-type mouse induces profound muscle hypertrophy, we applied a soluble ActRIIB receptor to models of disuse (limb immobilization) and denervation (sciatic nerve resection) atrophy. (biologists.org)
- Denervation atrophy, however, was not protected by ActRIIB treatment, yet resulted in an upregulation of the pro-growth factors Akt, SGK and components of the mTOR pathway. (biologists.org)
- Thus, our studies show that denervation atrophy is not only independent from Akt, SGK and mTOR activation but also has a different underlying pathophysiological mechanism than disuse atrophy. (biologists.org)
- Muscles biopsies also showed scattered atrophy consistent with the process of denervation. (lexico.com)
Resistant2
- The DERENEDIAB study is a proof-of-concept, multi-center, prospective, open, randomized, controlled study of the effectiveness of renal denervation in addition to standardized medical treatment compared to medical treatment alone in diabetic subjects with diabetic nephropathy and resistant proteinuria. (clinicaltrials.gov)
- Our pilot study data indicate interventional treatment with renal denervation decreases blood pressure, and most important, slows or even halts the decline of renal function in treatment-resistant patients with chronic kidney disease," Schmieder said in a statement. (empr.com)
Percutaneous1
- Covidien is the latest in a line of companies entering the renal denervation business, as it will unveil its new OneShot renal denervation system at the EuroPCR (European Association for Percutaneous Cardiovascular Interventions) congress in Paris, France, on May 16. (medgadget.com)
Chronic8
- Key results No high-quality evidence shows that radiofrequency denervation provides pain relief for patients with chronic low back pain. (cochrane.org)
- Radiofrequency (RF) denervation, an invasive treatment for chronic low back pain (CLBP), is used most often for pain suspected to arise from facet joints, sacroiliac (SI) joints or discs. (cochrane.org)
- Catheter-based renal sympathetic denervation: chronic preclinical evidence for renal artery safety. (springer.com)
- Since some experimental and observational data suggest an antiarrhythmic effect, it is possible that renal denervation might also play a therapeutic role in arrhythmias often occurring in chronic heart failure. (ovid.com)
- Cerebral artery mass in the rabbit is reduced by chronic sympathetic denervation. (ahajournals.org)
- In addition, the activation of adenyl cyclase by maximal as well as by submaximal concentrations of the catecholamine was potentiated by chronic denervation, indicating that there was more enzyme rather than a greater affinity of adenyl cyclase for norepinephrine. (fluoridealert.org)
- Denervated muscles undergo a characteristic pattern of changes on MR images as the denervation evolves from an acute phase through a subacute and then chronic phase (2-4) . (ajnr.org)
- Electrophysiological examination showed evidence of chronic partial denervation and reinnervation only in the upper limb segments. (lexico.com)
Field of renal denervation1
- This is the first blinded trial or sham controlled trial in the field of renal denervation. (medicalxpress.com)
Rationale for renal denervation1
- Heart failure: The pathophysiology of heart failure seems to support the rationale for renal denervation. (acc.org)
Ultrasound-based renal denervation2
- The RADIANCE-HTN SOLO trial was a multicenter randomized controlled trial that demonstrated the blood pressure lowering effect of endovascular ultrasound-based renal denervation compared with a sham control. (brightsurf.com)
- These results are consistent with the primary RADIANCE-HTN SOLO results demonstrating the blood pressure lowering effect of ultrasound-based renal denervation. (brightsurf.com)
Treatment20
- Based on the reduction in ambulatory SBP from an average of 154 to 148 mm Hg and in office-based SBP from 162 to 152 mm Hg, patients treated with denervation would still need to take medications to achieve currently recommended BP treatment targets, which are only likely to go lower with revision of guidelines around the world, he said. (medscape.com)
- Spironolactone versus renal nerve denervation for treatment. (lww.com)
- According to research, renal denervation leads to better outcomes than standard drug treatment in patients with advanced heart failure. (medindia.net)
- Patients with a positive response to a diagnostic block or to discography were given radiofrequency denervation, a placebo or a comparison treatment. (cochrane.org)
- The objective of this review is to assess the effectiveness of RF denervation procedures for the treatment of patients with CLBP. (cochrane.org)
- Cardiac sympathetic denervation for conventional treatment refractory arrhythmias. (medworm.com)
- We are excited to move forward in our collaboration with Otsuka to make the Paradise renal denervation system a standard of care for treatment of hypertensive patients worldwide," added COO and founder Mano Iyer. (massdevice.com)
- Patients with high blood pressure and atrial fibrillation might benefit from the regular treatment, which is isolation of the pulmonary veins, by adding renal sympathetic denervation to their treatment. (rug.nl)
- Renal denervation: a potential new treatment modality for polycystic ovary syndrome? (nih.gov)
- The major adverse event rate of 1.4 percent for renal denervation comfortably met the safety goal of 9.8 percent, compared with 0.3 percent in the sham treatment arm. (medicalxpress.com)
- Renal denervation does not involve any pharmacological treatment. (bio-medicine.org)
- The aim of this pilot study was to compare the outcomes of patients with advanced heart failure receiving standard pharmacological treatment or renal denervation. (bio-medicine.org)
- Over the period of one year, 26 patients were treated with renal denervation and standard pharmacotherapy and 25 patients received standard drug treatment with beta-blockers, ACE inhibitors or ARBs and diuretics. (bio-medicine.org)
- The disadvantage of denervation, as with any invasive treatment, is the potential for subsequent complications. (bio-medicine.org)
- The findings indicate that renal denervation may be a non-pharmacological alternative for the treatment of patients with advanced heart failure and may help stabilise the disease. (bio-medicine.org)
- The FDA Breakthrough Device Program is intended to help patients receive more timely access to certain technologies, such as renal denervation, that have the potential to provide more effective treatment or diagnosis for life-threatening or irreversibly debilitating diseases or conditions. (globenewswire.com)
- I believe there's a logical reason why renal denervation may be a useful approach in this area," he stated, "and it may expand treatment over and above the neurohormonal blockade and other pharmacological therapies available today. (acc.org)
- In this study, patients were randomized to renal denervation or intensified medical treatment. (eshonline.org)
- The 51 patients in the renal denervation group and the 50 patients in the medical treatment group were similar at baseline, except the body mass index (BMI) was significantly higher in the medical treatment group ( Table 1 and Table 2 ). (eshonline.org)
- In contrast, in the PP analysis, a significant between-group difference was found, based on a greater reduction in 24-hour SBP in the medical treatment group than in the renal denervation group (15 mmHg vs 6.3 mmHg, respectively). (eshonline.org)
Renal denervation catheter1
- The renal denervation catheter is introduced through the femoral artery in the upper thigh. (emailwire.com)
Cardiac sympathetic denervation6
- Cardiac sympathetic denervation preceding motor signs in Parkinson disease. (biomedsearch.com)
- Left cardiac sympathetic denervation (LCSD) suppresses ventricular arrhythmias (VAs), and reduces the incidence of sudden cardiac death (SCD). (ahajournals.org)
- The role of bilateral cardiac sympathetic denervation (BCSD) remains unknown. (ahajournals.org)
- Surgical BCSD was successfully performed in all patients (50% simultaneously, 50% right cardiac sympathetic denervation after prior unsuccessful LCSD). (ahajournals.org)
- In these patients with electrical storm refractory to standard therapies, bilateral cardiac sympathetic denervation was safe and effective in acutely suppressing VAs, and preventing SCD. (ahajournals.org)
- 123)I-Labelled metaiodobenzylguanidine for the evaluation of cardiac sympathetic denervation in early stage amyloidosis. (biomedsearch.com)
Medtronic's1
- This feasibility study represents Medtronic's commitment to providing physicians with a broader range of solutions for performing renal denervation and to collaborating with physician partners in the ongoing evaluation of this ground-breaking therapy. (mdtmag.com)
20183
- Annualized total Renal Denervation market revenue by segment and market outlooks from 2018-2024. (reportbuyer.com)
- Annualized US renal denervation market revenue and future forecasts from 2009 to 2011, forecast for 7 years to 2018. (globaldialysis.com)
- Access market sizing, forecasts and quantified growth opportunities in the US renal denervation market through 2018. (globaldialysis.com)
Catheter is introduced1
- During renal sympathetic denervation, a catheter is introduced using standard interventional technique via the femoral artery, and is positioned in the renal artery under fluoroscopic guidance. (terumo-europe.com)
Pivotal trial1
- However, Medtronic received FDA approval in May for a pivotal trial to evaluate the Simplicity Renal Denervation System for patients with high blood pressure. (mddionline.com)
Process of denervation2
- Those with post polio syndrome are undergoing a constant process of denervation and reinnervation . (wikipedia.org)
- This process of denervation is however different from post-polio syndrome in that it only involves upper and lower motor neuron degeneration and does not experience a process of constant reinnervation and denervation. (wikipedia.org)
Consistent with denervation2
- In addition, T2 prolongation and postcontrast enhancement were identified in the right-sided muscles of mastication and muscles of facial expression, consistent with denervation change. (ajnr.org)
- A muscle biopsy confirmed neuropathic changes in a pattern consistent with denervation. (lexico.com)
Medtronic2
- Otsuka Holdings is set to acquire ReCor Medical for an undisclosed sum and follows Medtronic in a bid to get a renal denervation device on the market. (mddionline.com)
- The Medtronic Multi-electrode Radiofrequency Renal Denervation System is comprised of a single-use, disposable catheter and a reusable generator. (clinicaltrials.gov)
Blood pressure14
- If your blood pressure is normal but you are on many medications, could renal denervation enable you to reduce or eliminate lifelong medications? (huffingtonpost.com)
- Indeed, in 10 patients, blood pressure actually increased after denervation. (medscape.com)
- A new meta-analysis of six sham-controlled studies of renal sympathetic denervation (RSD) has shown a significant reduction in blood pressure with the technique. (medscape.com)
- Aronow explained that a number of early studies suggested that renal sympathetic denervation was associated with reduced blood pressure, and the results with surgical denervation were very positive. (medscape.com)
- Later studies have included more extensive denervation than earlier studies and also have used ambulatory blood pressure monitoring to assess pressures over the full 24-hour period, which are much more reliable, he said. (medscape.com)
- This meta-analysis as a whole has shown a significant benefit of denervation over sham control, but when we looked at the more recent trials we saw a larger reduction in blood pressure with denervation than was seen in the earlier trials. (medscape.com)
- In recent years, concerns have been raised that the magnitude of the blood pressure reductions seen in renal denervation studies without control groups would not hold up in controlled trials, and those concerns now appear to be well founded. (medpagetoday.com)
- There is ample data that renal denervation reduces blood pressure in animal models and in smaller human trials, and there are at least 30 different methods being tested to denervate the renal arteries. (medpagetoday.com)
- In our case, we present a 39-year-old patient with high blood pressure (BP) of 10-year evolution, left ventricular hypertrophy, and left putaminal hypertensive intracranial hemorrhage, which occurred one year before denervation. (ahajournals.org)
- Renal denervation achieved by intravascular delivery of radiofrequency energy or ultrasound energy might produce similar blood pressure lowering and the RADIANCE-HTN SOLO and SPYRAL trials take the renal denervation field into a new era. (healio.com)
- This thesis is a collection of research regarding high blood pressure and renal sympathetic denervation. (rug.nl)
- These findings corroborate the relevance of sympathetic activation in PCOS and suggest that renal denervation exerts beneficial effects not only on blood pressure control but also on insulin sensitivity, renal, and endocrine abnormalities characteristic of PCOS. (nih.gov)
- Still, renal denervation is supported by a strong rationale and is occasionally followed by major blood pressure responses in at-risk patients who may otherwise have remained uncontrolled. (springer.com)
- 2. Chemical denervation reduced the blood pressure of both strains of rats, but the denervated spontaneously hypertensive rats were still hypertensive with respect to their denervated Wistar-Kyoto controls. (portlandpress.com)
OneShot1
- Covidien [1] plc has announced it will exit its OneShot Renal Denervation program. (mdtmag.com)
Nerves5
- If the nerves lost to denervation are part of the neuronal communication to a specific function in the body then altered or a loss of physiological functioning can occur. (wikipedia.org)
- The thesis shows the results of enhancement of the regular renal denervation with a technique that uses electrical energy to find these sympathetic nerves. (rug.nl)
- Conclusions- CHEP offers a noninvasive approach to evaluate the degeneration of thermonociceptive nerves in diabetic neuropathy by providing physiological correlates of skin denervation and neuropathic pain. (diabetesjournals.org)
- It is a multiple application of radiofrequency energy using a thin catheter via the femoral artery and a long-term "denervation" of the sympathetic nerves around the renal arteries. (bio-medicine.org)
- Summary: Denervation changes in muscle following damage to cranial and peripheral nerves can be observed on both CT and MR imaging studies. (ajnr.org)
Effects of renal1
- He concluded: "The long-term effects of renal denervation should be confirmed in a large international randomised study. (bio-medicine.org)
Effectiveness of renal1
- Lastly, the book focuses on the cost effectiveness of renal denervation and future directions for other possible benefits. (springer.com)
Device2
- Written by world renowned leaders in the field, Renal Denervation will be of immediate use to cardiologists, nephrologists and urologists as well as allied health professionals, device companies and anyone working in this field. (springer.com)
- Numerous medical device news sources and industry executives have proclaimed renal denervation to be the top medical device breakthrough of the past two years, and for good reason. (globaldialysis.com)
Intervention2
- These differences were obtained with a similar number of anti-hypertensives and drug-adherence in both groups as well as an acceptable safety profile for the intervention (three minor adverse events with renal denervation and a comparable decrease in estimated glomerular filtration rate in both groups). (bmj.com)
- The renal denervation market in the United States will grow from essentially nothing in 2012 as the intervention was not approved for any indication in the United States in 2012. (globaldialysis.com)
Endpoint1
- The researchers suggest the better results with denervation in the second-generation studies might be explained by differences in patients enrolled, procedural technique employed, antihypertensive drug regimens prescribed, and endpoint ascertainment. (medscape.com)
Muscle denervation3
- Following an acute polio infection diagnosis symptoms such as fatiguability , general weakness and pain are believed to be correlated to muscle denervation. (wikipedia.org)
- In regard to skeletal muscle denervation there are two distinct diagnoses: entrapment and compressive neuropathies or non-entrapment neuropathies. (wikipedia.org)
- MR imaging has the advantage of providing some earlier insight into the pathophysiological changes that accompany muscle denervation, and also sensitivity to the time course of the process. (ajnr.org)