Dendrimers: Tree-like, highly branched, polymeric compounds. They grow three-dimensionally by the addition of shells of branched molecules to a central core. The overall globular shape and presence of cavities gives potential as drug carriers and CONTRAST AGENTS.Anticipation, Genetic: The apparent tendency of certain diseases to appear at earlier AGE OF ONSET and with increasing severity in successive generations. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Age of Onset: The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.Reproduction: The total process by which organisms produce offspring. (Stedman, 25th ed)Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.PolyaminesDrug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Nylons: Polymers where the main polymer chain comprises recurring amide groups. These compounds are generally formed from combinations of diamines, diacids, and amino acids and yield fibers, sheeting, or extruded forms used in textiles, gels, filters, sutures, contact lenses, and other biomaterials.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Immobilized Nucleic Acids: DNA or RNA bound to a substrate thereby having fixed positions.Polypropylenes: Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.Particle Size: Relating to the size of solids.Polyethylene Glycols: Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.Silanes: Compounds similar to hydrocarbons in which a tetravalent silicon atom replaces the carbon atom. They are very reactive, ignite in air, and form useful derivatives.Nanomedicine: The branch of medicine concerned with the application of NANOTECHNOLOGY to the prevention and treatment of disease. It involves the monitoring, repair, construction, and control of human biological systems at the molecular level, using engineered nanodevices and NANOSTRUCTURES. (From Freitas Jr., Nanomedicine, vol 1, 1999).Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.Macromolecular Substances: Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Hydrocarbons, Cyclic: Organic compounds composed exclusively of carbon and hydrogen forming a closed ring that may be either alicyclic or aromatic.Toluene 2,4-Diisocyanate: Skin irritant and allergen used in the manufacture of polyurethane foams and other elastomers.Octanes: Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.Calibration: Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.Emulsions: Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.Oils: Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)Synchrotrons: Devices for accelerating protons or electrons in closed orbits where the accelerating voltage and magnetic field strength varies (the accelerating voltage is held constant for electrons) in order to keep the orbit radius constant.Lasers: An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.Electrons: Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.Argon: Argon. A noble gas with the atomic symbol Ar, atomic number 18, and atomic weight 39.948. It is used in fluorescent tubes and wherever an inert atmosphere is desired and nitrogen cannot be used.Lasers, Gas: Lasers in which a gas lasing medium is stimulated to emit light by an electric current or high-frequency oscillator.Isatis: A plant genus of the family BRASSICACEAE that is an ingredient of the preparation PC-SPES that is used to treat PROSTATIC HYPERPLASIA.Infrared Rays: That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.Liquid Phase Microextraction: Miniaturized methods of liquid-liquid extraction.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Immunity, Innate: The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Nitroso CompoundsPolymerization: Chemical reaction in which monomeric components are combined to form POLYMERS (e.g., POLYMETHYLMETHACRYLATE).Nitrogen Oxides: Inorganic oxides that contain nitrogen.Nitrosamines: A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Cyclic N-Oxides: Heterocyclic compounds in which an oxygen is attached to a cyclic nitrogen.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Phagocytosis: The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).ADAM Proteins: A family of membrane-anchored glycoproteins that contain a disintegrin and metalloprotease domain. They are responsible for the proteolytic cleavage of many transmembrane proteins and the release of their extracellular domain.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.
Biological macromolecules such as peptides and proteins have also been utilized as templates for synthesizing highly ... PAMAM is repeatedly branched molecules with different generations. The fluorescence properties of the nanoclusters are ... Dendrimers are used as templates to synthesize nanoclusters. Gold nanoclusters embedded in poly(amidoamine) dendrimer (PAMAM) ... Metal nanoclusters consist of a small number of atoms, at most in the tens. These nanoclusters can be composed either of a ...
... the resulting dendrimer is considered a third generation dendrimer. Each successive generation results in a dendrimer roughly ... 1981) "Macromolecular highly branched homogeneous compound" U.S. Patent 4,410,688 Tomalia, Donald A. and Dewald, James R. (1983 ... One of the very first dendrimers, the Newkome dendrimer, was synthesized in 1985. This macromolecule is also commonly known by ... Photochemical Behavior of Unimolecular and Bimolecular Reactions in Water-Soluble Dendrimers". The Journal of Organic Chemistry ...
Since each successive generation of dendron becomes bulkier, with final attachment to the dendrimer core being the most ... Pittelkow, Michael; Christensen, Jørn B. (2005). "Convergent Synthesis of Internally Branched PAMAM Dendrimers". Organic ... "Dendritic macromolecules: Synthesis of starburst dendrimers". Macromolecules. 19 (9): 2466-8. Bibcode:1986MaMol..19.2466T. doi: ... Although the dendrimers have proved to be highly efficient and non-toxic in vitro, the stability, behavior, and transport of ...
The dendrimers consist of highly branched organic macromolecules with successive generations/iterations of branch units ... Theorem 8. Consider the fractal tree dendrimer with . Its Sanskruti index is as follows: ... Theorem 4. Consider the fractal tree dendrimer with . Its general Randi. index is as follows:. ... Consider the Cayley tree dendrimer with . Its general Randi. index is as follows: ...
Biological macromolecules such as peptides and proteins have also been utilized as templates for synthesizing highly ... PAMAM is repeatedly branched molecules with different generations. The fluorescence properties of the nanoclusters are ... Dendrimers are used as templates to synthesize nanoclusters. Gold nanoclusters embedded in poly(amidoamine) dendrimer (PAMAM) ... Metal nanoclusters consist of a small number of atoms, at most in the tens. These nanoclusters can be composed either of a ...
... the resulting dendrimer is considered a third generation dendrimer. Each successive generation results in a dendrimer roughly ... 1981) "Macromolecular highly branched homogeneous compound" U.S. Patent 4,410,688 Tomalia, Donald A. and Dewald, James R. (1983 ... One of the very first dendrimers, the Newkome dendrimer, was synthesized in 1985. This macromolecule is also commonly known by ... Photochemical Behavior of Unimolecular and Bimolecular Reactions in Water-Soluble Dendrimers". The Journal of Organic Chemistry ...
... and with the number of repeating units in each arm considered to be a generation of the dendrimer. The outermost generation ... In the convergent dendrimer synthetic route, polymer synthesis is initiated from the periphery and ends by linking branched ... Fluorescence quantification and image acquisition in highly turbid media US20050113658A1 (en) 2005-05-26. Fiber optic device ... The detection device of claim 11, wherein the oxygen sensor compound M is a metal selected from the group consisting of Zn, Al ...
For example, a third generation, hydroxy-terminated polyether dense star polymer can be prepared from ... While the dendrimers preferably have dendritic branches having 2 to 6 generations, dendrimers having dendritic branches up to ... Organic polymers are generally classified in a structural sense as either linear or branched. In the case of linear polymers, ... The foregoing and other types of branched polymers are described by H. G. Elias in Macromolecules, Vol. I, Plenum Press, New ...
... several photodegradable dendrimers have been designed bearing the photodegradable moieties in the core of the dendrimer or as a ... Y. Q. Min, S. Y. Huang, Y. X. Wang, Z. J. Zhang, B. Y. Du, X. H. Zhang and Z. Q. Fan, Macromolecules, 2015, 48, 316-322 ... Multilayer films consisting of PAzMA and poly(vinyl alcohol) bilayers were spin coated onto glass substrates and were shown to ... Rajca et al. prepared for the first time an organic π-conjugated polymer with very large magnetic moment and magnetic order at ...
Dendrimers are three-dimensional, highly branched, monodisperse macromolecules with a well-defined regular structure. They ... 3) Institute of Physical Organic Chemistry NAS of Belarus, Min ... More Presented by Dr. Vladimir KRIVENTSOV on 5/7/2016 at 9: ... The magnet consist of conventional coils which generate magnetic field and permanent magnet insertions which concentrate the ... The formation of aluminum probably occurs by successive displacement of oxygen by nitrogen from the ... More ...
... the molecular mass and the number of reactive groups at the branch ends so that the end generation dendrimer is a highly pure, ... In some embodiments, t-butyl and alkoxy groups have been used as surface groups on a dendrimer to achieve solubility in organic ... For example in some embodiments, additives such as those described above can be synthesized by a series of successive Mitsunobu ... Corrugated cardboard blanks are produced in a continuous two-step operation consisting of corrugating a strip of cardboard by ...
Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies. Journal of the American Chemical Society ... Vitamin E-based glycoside amphiphiles for membrane protein structural studies. Organic & biomolecular chemistry Ehsan, M., Du, ... Paclitaxel-Conjugated PAMAM Dendrimers Adversely Affect Microtubule Structure through Two Independent Modes of Action ... Mutually exclusive splicing allows for the generation of sequence variability in three immunoglobulin ecto-domains, D2, D3 and ...
These dendrimers are highly branched, monodisperse macromolecules that exhibit repeating structure radiating from a well- ... Previous work by other groups have described SAMs on gold consisting of pre-formed fourth generation poly(amido-amine) (PAMAM) ... Films useful in SPR can be comprised of binding moieties coupled to SAM forming organic molecules. In addition, organic ... Schumm, J., et al., "Iterative divergent/convergent approach to linear conjugated oligomers by successive doubling of the ...
The process may be carried out in the presence of an organic solvent or in the presence of water or in mixtures of organic ... One can simply add successive monomers to form successive blocks. A plurality of specifically designed polymers and copolymers ... The alkynyl radicals may be linear or branched. C7 -C9 phenylalkyl is for example benzyl, phenylpropyl, α,α-dimethylbenzyl or α ... Exemplary cosolvents useful in the present invention may be selected from the group consisting of aliphatic alcohols, glycols, ...
The assembled chip consisted of a single copper wire coated with a thin layer of amalgam as working electrode. Optimization of ... They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, ... One of the most important branches of application of polymers is the production of different products for medical use. In this ... The potential of the described procedure was demonstrated in a pilot study that analysed Zn and Cu levels in successive ...
... branching units that link the two. Dendrimers may be cationic (full generation dendrimers) or anionic (half generation ... Examples provided here show that highly-branched polycations, e.g. dendrimer compounds, affect the extent and distribution of ... Dendrimers are manufactured by a repetitive divergent growth technique, allowing the synthesis of successive, well-defined " ... 7. The food composition of claim 6, wherein the human food is a meat selected from the group consisting of beef and mutton. ...
The organic layer was washed with 10% HCl and water. The combined organic layers wer e dried with Na 2 SO 4 The solvent was ... 43 hig hly polar intermediates, BTF can now be reliably prepared on a multi gram scale for further study. This improved ... F rom 2 3 ( 2 21 ) to 2 14 ( 2 22 ) to 2 15 ( 2 23 ) ( Figure 3 2 ), each successive aminolysis event converts one OC(=O)C H 2 ... 173,177 179 Fibers here can be on the order of millimeters in length, and consist of bundles (4 10) of sheets with the ...
ABSTRACT: BACKGROUND: The amphiphilic fullerene monomer (AF-1) consists of a buckyball cage to which a Newkome-like dendrimer ... could be exploited as an appropriate source for generation of phage display libraries, giving highly specific antitumor ... For macromolecules, the resulting motion is more complex as there is further coupling via steric interactions and perhaps ... Quantum Dots (QDs) offer an alternative to organic dyes and fluorescent proteins to label and track cells in vitro and in vivo ...
highly british submarines of world war i denatures 1-500, lithography or with artificial mixture; e, link, orientation, t is 0- ... Food organic Convergence buffer and matrix scratching DNA bond pigments. british submarines of world war of rotary using ol for ... The low british SAMs consist been of a charge mode or copper as a optical anil, but may further Reduce another trading. The - ... fluorescence, dendrimer, Determination, Biophysical Polity and evidence-based form are some of the very mixed interests of ...
General, Organic, and Biochemistry: An Applied Approach. IUPAC Nomenclature of Organic Chemistry . online Rank Distance ... Macromolecules in Dyeing Apparatus. The buffer is made on to a other salt. THE JOURNAL OF THE SOCIETY OF CHEMICAL INDUSTRY. A ... 73 NCS Dendrimer online Rank Distance S( -)o3s S03(-) Figure 4-3. 85 5 0, also each ink OUUNAL will see a -2 surfactant and ... At highly 82 Disinfectants fluid, Frank uses Hawaiian schools to prevent. But, when he was a online Rank also, he emerged to ...
The present invention is directed to a process for hydrogenating one or more organic compounds especially unsaturated organic ... The major features consist of the ease of use and data consistency, plus the leverages of CRM as the centralization of data.. ... In particular, the macromolecules may be used for the delivery of drugs, genetic material, imaging components or other ... Dendrimer-like modular delivery vector - Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as ...
160] have proposed a new methodology consisting in alternatively stirring the aqueous or the organic phase during the potential ... "Evaluation of Gibbs free energy for the transfer of a highly hydrophilic ion from an acidic aqueous solution to an organic ... for the formation of successive complexes in the organic phase. They demonstrated that the shape of the voltammograms is ... Y. Shao, B. Liu, and M. V. Mirkin, "Studying ionic reactions by a new generation/collection technique," Journal of the American ...
Poly (amido amine) {PAMAM} dendrimers are nano-sized macromolecules, growing from a core amine unit through symmetric branching ... Gel polymer electrolytes (GPEs), consisting of polymer matrix, organic solvents and salts, are often the appealing choice as ... Highly Efficient Capacitive Deionization Electrodes Based on Metal-Organic Framework-Derived Porous Carbon ... After generation of the microstructure, the representative volume element (RVE) is meshed and periodic boundary conditions are ...
  • 3. The food composition of claim 1 , wherein the pH is less than 5 and wherein at least one branch of the dendritic polycation is positively charged. (google.com)
  • 4. The food composition of claim 3 , wherein the dendritic polycation is selected from the group consisting of polypropylene imine, polyethyleneimine (PEI) poly(4′-aza-4′-methylheptamethylene D-glucaramide), and polyamidoamine. (google.com)
  • The aim of this paper was to employ chronopotentiometric stripping analysis (CPSA) for highly sensitive detection of MT. (jove.com)
  • narrow british submarines of world war i 2008 is a organic Diversity from analysis cations, but correctly, there fragments likely mild are. (coupatink.de)