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Deep Brain StimulationSubthalamic NucleusGlobus PallidusParkinson DiseaseHypokinesiaElectrodes, ImplantedEssential TremorStereotaxic TechniquesElectric Stimulation TherapyAntiparkinson AgentsDystoniaDyskinesiasThalamusLevodopaBasal GangliaElectric StimulationTremorMovement DisordersBeta RhythmInternal CapsuleSubthalamusElectrodesDystonic DisordersBrainPedunculopontine Tegmental NucleusTranscranial Magnetic StimulationMuscle RigidityObsessive-Compulsive DisorderModels, NeurologicalBrain MappingParkinsonian DisordersSpeech DisordersSelf StimulationMagnetic Resonance ImagingTourette SyndromeTreatment OutcomeNeural PathwaysNeurosurgical ProceduresPsychosurgeryMicroelectrodesThalamic DiseasesImplantable NeurostimulatorsFunctional LateralitySensation DisordersNeuronsCluster HeadacheDopamine AgentsVagus Nerve StimulationAmplifiers, ElectronicIntralaminar Thalamic NucleiNucleus AccumbensEntopeduncular NucleusBrain ChemistryTime FactorsMotor SkillsDifferential ThresholdElectric CapacitanceElectroencephalographyCarbidopaPallidotomyNeuropsychological TestsNerve NetNeurosurgeryDysarthriaNeurologic ExaminationSignal Processing, Computer-AssistedElectromyographyTicsNeuropsychiatryMotor CortexVentral Thalamic NucleiMyoclonusTorticollisDominance, CerebralAtlases as TopicTherapeutic MisconceptionApomorphineReaction TimeParkinson Disease, SecondaryElectroconvulsive TherapyNeural InhibitionGait Disorders, NeurologicBrain InjuriesAction Potentials1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnalysis of VarianceThermometryMedial Forebrain BundleCerebral CortexEvoked PotentialsDepressive Disorder, Treatment-ResistantBrain NeoplasmsRats, Sprague-DawleyElectrochemical TechniquesSeverity of Illness IndexComputer SimulationMovementBiomedical EnhancementMotor ActivitySubstantia NigraCognitionNeuronal PlasticityStatistics, Nonparametric
Deep Brain Stimulation: Therapy for MOVEMENT DISORDERS, especially PARKINSON DISEASE, that applies electricity via stereotactic implantation of ELECTRODES in specific areas of the BRAIN such as the THALAMUS. The electrodes are attached to a neurostimulator placed subcutaneously.Subthalamic Nucleus: Lens-shaped structure on the inner aspect of the INTERNAL CAPSULE. The SUBTHALAMIC NUCLEUS and pathways traversing this region are concerned with the integration of somatic motor function.Globus Pallidus: The representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus.Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)Hypokinesia: Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged inactivity due to illness; and other conditions.Electrodes, Implanted: Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body.Essential Tremor: A relatively common disorder characterized by a fairly specific pattern of tremors which are most prominent in the upper extremities and neck, inducing titubations of the head. The tremor is usually mild, but when severe may be disabling. An autosomal dominant pattern of inheritance may occur in some families (i.e., familial tremor). (Mov Disord 1988;13(1):5-10)Stereotaxic Techniques: Techniques used mostly during brain surgery which use a system of three-dimensional coordinates to locate the site to be operated on.Electric Stimulation Therapy: Application of electric current in treatment without the generation of perceptible heat. It includes electric stimulation of nerves or muscles, passage of current into the body, or use of interrupted current of low intensity to raise the threshold of the skin to pain.Antiparkinson Agents: Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)Dyskinesias: Abnormal involuntary movements which primarily affect the extremities, trunk, or jaw that occur as a manifestation of an underlying disease process. Conditions which feature recurrent or persistent episodes of dyskinesia as a primary manifestation of disease may be referred to as dyskinesia syndromes (see MOVEMENT DISORDERS). Dyskinesias are also a relatively common manifestation of BASAL GANGLIA DISEASES.Thalamus: Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.Basal Ganglia: Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres.Electric Stimulation: Use of electric potential or currents to elicit biological responses.Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.Movement Disorders: Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.Beta Rhythm: Brain waves with frequency between 15-30 Hz seen on EEG during wakefulness and mental activity.Internal Capsule: WHITE MATTER pathway, flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the WHITE MATTER and the BRAINSTEM. It consists of three distinct parts: an anterior limb, posterior limb, and genu.Subthalamus: A transition zone in the anterior part of the diencephalon interposed between the thalamus, hypothalamus, and tegmentum of the mesencephalon. Components of the subthalamus include the SUBTHALAMIC NUCLEUS, zona incerta, nucleus of field H, and the nucleus of ansa lenticularis. The latter contains the ENTOPEDUNCULAR NUCLEUS.Electrodes: Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.Dystonic Disorders: Acquired and inherited conditions that feature DYSTONIA as a primary manifestation of disease. These disorders are generally divided into generalized dystonias (e.g., dystonia musculorum deformans) and focal dystonias (e.g., writer's cramp). They are also classified by patterns of inheritance and by age of onset.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Pedunculopontine Tegmental Nucleus: Dense collection of cells in the caudal pontomesencephalic tegmentum known to play a role in the functional organization of the BASAL GANGLIA and in the modulation of the thalamocortical neuronal system.Transcranial Magnetic Stimulation: A technique that involves the use of electrical coils on the head to generate a brief magnetic field which reaches the CEREBRAL CORTEX. It is coupled with ELECTROMYOGRAPHY response detection to assess cortical excitability by the threshold required to induce MOTOR EVOKED POTENTIALS. This method is also used for BRAIN MAPPING, to study NEUROPHYSIOLOGY, and as a substitute for ELECTROCONVULSIVE THERAPY for treating DEPRESSION. Induction of SEIZURES limits its clinical usage.Muscle Rigidity: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.Models, Neurological: Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Brain Mapping: Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.Speech Disorders: Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.Self Stimulation: Stimulation of the brain, which is self-administered. The stimulation may result in negative or positive reinforcement.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Neural Pathways: Neural tracts connecting one part of the nervous system with another.Neurosurgical Procedures: Surgery performed on the nervous system or its parts.Psychosurgery: Treatment of chronic, severe and intractable psychiatric disorders by surgical removal or interruption of certain areas or pathways in the brain, especially in the prefrontal lobes.Microelectrodes: Electrodes with an extremely small tip, used in a voltage clamp or other apparatus to stimulate or record bioelectric potentials of single cells intracellularly or extracellularly. (Dorland, 28th ed)Thalamic Diseases: Disorders of the centrally located thalamus, which integrates a wide range of cortical and subcortical information. Manifestations include sensory loss, MOVEMENT DISORDERS; ATAXIA, pain syndromes, visual disorders, a variety of neuropsychological conditions, and COMA. Relatively common etiologies include CEREBROVASCULAR DISORDERS; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; BRAIN HYPOXIA; INTRACRANIAL HEMORRHAGES; and infectious processes.Implantable Neurostimulators: Surgically placed electric conductors through which ELECTRIC STIMULATION of nerve tissue is delivered.Functional Laterality: Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.Sensation Disorders: Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of the PERIPHERAL NERVOUS SYSTEM).Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Cluster Headache: A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Dopamine Agents: Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.Vagus Nerve Stimulation: An adjunctive treatment for PARTIAL EPILEPSY and refractory DEPRESSION that delivers electrical impulses to the brain via the VAGUS NERVE. A battery implanted under the skin supplies the energy.Amplifiers, Electronic: Electronic devices that increase the magnitude of a signal's power level or current.Intralaminar Thalamic Nuclei: Cell groups within the internal medullary lamina of the THALAMUS. They include a rostral division comprising the paracentral, central lateral, central dorsal, and central medial nuclei, and a caudal division composed of the centromedian and parafascicular nuclei.Nucleus Accumbens: Collection of pleomorphic cells in the caudal part of the anterior horn of the LATERAL VENTRICLE, in the region of the OLFACTORY TUBERCLE, lying between the head of the CAUDATE NUCLEUS and the ANTERIOR PERFORATED SUBSTANCE. It is part of the so-called VENTRAL STRIATUM, a composite structure considered part of the BASAL GANGLIA.Entopeduncular Nucleus: A portion of the nucleus of ansa lenticularis located medial to the posterior limb of the internal capsule, along the course of the ansa lenticularis and the inferior thalamic peduncle or as a separate nucleus within the internal capsule adjacent to the medial GLOBUS PALLIDUS (NeuroNames, http://rprcsgi.rprc. washington.edu/neuronames/ (September 28, 1998)). In non-primates, the entopeduncular nucleus is analogous to both the medial globus pallidus and the entopeduncular nucleus of human.Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Motor Skills: Performance of complex motor acts.Differential Threshold: The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.Electric Capacitance: The ability of a substrate to retain an electrical charge.Electroencephalography: Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.Carbidopa: An inhibitor of DOPA DECARBOXYLASE, preventing conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. It has no antiparkinson actions by itself.Pallidotomy: Producing a lesion in the posteroventral portion of the medial GLOBUS PALLIDUS to treat PARKINSON DISEASE and other extrapyramidal disorders. The placement of the lesion is aided by STEREOTACTIC TECHNIQUES and imaging procedures.Neuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Nerve Net: A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.Neurosurgery: A surgical specialty concerned with the treatment of diseases and disorders of the brain, spinal cord, and peripheral and sympathetic nervous system.Dysarthria: Disorders of speech articulation caused by imperfect coordination of pharynx, larynx, tongue, or face muscles. This may result from CRANIAL NERVE DISEASES; NEUROMUSCULAR DISEASES; CEREBELLAR DISEASES; BASAL GANGLIA DISEASES; BRAIN STEM diseases; or diseases of the corticobulbar tracts (see PYRAMIDAL TRACTS). The cortical language centers are intact in this condition. (From Adams et al., Principles of Neurology, 6th ed, p489)Neurologic Examination: Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.Signal Processing, Computer-Assisted: Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.Electromyography: Recording of the changes in electric potential of muscle by means of surface or needle electrodes.Tics: Habitual, repeated, rapid contraction of certain muscles, resulting in stereotyped individualized actions that can be voluntarily suppressed for only brief periods. They often involve the face, vocal cords, neck, and less often the extremities. Examples include repetitive throat clearing, vocalizations, sniffing, pursing the lips, and excessive blinking. Tics tend to be aggravated by emotional stress. When frequent they may interfere with speech and INTERPERSONAL RELATIONS. Conditions which feature frequent and prominent tics as a primary manifestation of disease are referred to as TIC DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, pp109-10)Neuropsychiatry: A subfield of psychiatry that emphasizes the somatic substructure on which mental operations and emotions are based, and the functional or organic disturbances of the central nervous system that give rise to, contribute to, or are associated with mental and emotional disorders. (From Campbell's Psychiatric Dictionary, 8th ed.)Motor Cortex: Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex.Ventral Thalamic Nuclei: A large group of nuclei lying between the internal medullary lamina and the INTERNAL CAPSULE. It includes the ventral anterior, ventral lateral, and ventral posterior nuclei.Myoclonus: Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles. This condition may be a feature of some CENTRAL NERVOUS SYSTEM DISEASES; (e.g., EPILEPSY, MYOCLONIC). Nocturnal myoclonus is the principal feature of the NOCTURNAL MYOCLONUS SYNDROME. (From Adams et al., Principles of Neurology, 6th ed, pp102-3).Torticollis: A symptom, not a disease, of a twisted neck. In most instances, the head is tipped toward one side and the chin rotated toward the other. The involuntary muscle contractions in the neck region of patients with torticollis can be due to congenital defects, trauma, inflammation, tumors, and neurological or other factors.Dominance, Cerebral: Dominance of one cerebral hemisphere over the other in cerebral functions.Atlases as Topic: Collections of illustrative plates, charts, etc., usually with explanatory captions.Therapeutic Misconception: Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.Apomorphine: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.Reaction Time: The time from the onset of a stimulus until a response is observed.Parkinson Disease, Secondary: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)Electroconvulsive Therapy: Electrically induced CONVULSIONS primarily used in the treatment of severe AFFECTIVE DISORDERS and SCHIZOPHRENIA.Neural Inhibition: The function of opposing or restraining the excitation of neurons or their target excitable cells.Gait Disorders, Neurologic: Gait abnormalities that are a manifestation of nervous system dysfunction. These conditions may be caused by a wide variety of disorders which affect motor control, sensory feedback, and muscle strength including: CENTRAL NERVOUS SYSTEM DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or MUSCULAR DISEASES.Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.Action Potentials: Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Thermometry: Measurement of the temperature of a material, or of the body or an organ by various temperature sensing devices which measure changes in properties of the material that vary with temperature, such as ELASTICITY; MAGNETIC FIELDS; or LUMINESCENCE.Medial Forebrain Bundle: A complex group of fibers arising from the basal olfactory regions, the periamygdaloid region, and the septal nuclei, and passing to the lateral hypothalamus. Some fibers continue into the tegmentum.Cerebral Cortex: The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.Evoked Potentials: Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.Depressive Disorder, Treatment-Resistant: Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies. (Campbell's Psychiatric Dictionary, 9th ed.)Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Electrochemical Techniques: The utilization of an electrical current to measure, analyze, or alter chemicals or chemical reactions in solution, cells, or tissues.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Movement: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.Biomedical Enhancement: The use of technology-based interventions to improve functional capacities rather than to treat disease.Motor Activity: The physical activity of a human or an animal as a behavioral phenomenon.Substantia Nigra: The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis.Cognition: Intellectual or mental process whereby an organism obtains knowledge.Neuronal Plasticity: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.Statistics, Nonparametric: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)

Mechanisms of deep brain stimulation: an intracellular study in rat thalamus. (1/725)

High-frequency deep brain stimulation (DBS) in the thalamus alleviates most kinds of tremor, yet its mechanism of action is unknown. Studies in subthalamic nucleus and other brain sites have emphasized non-synaptic factors. To explore the mechanism underlying thalamic DBS, we simulated DBS in vitro by applying high-frequency (125 Hz) electrical stimulation directly into the sensorimotor thalamus of adult rat brain slices. Intracellular recordings revealed two distinct types of membrane responses, both of which were initiated with a depolarization and rapid spike firing. However, type 1 responses repolarized quickly and returned to quiescent baseline during simulated DBS whereas type 2 responses maintained the level of membrane depolarization, with or without spike firing. Individual thalamic neurones exhibited either type 1 or type 2 response but not both. In all neurones tested, simulated DBS-evoked membrane depolarization was reversibly eliminated by tetrodotoxin, glutamate receptor antagonists, and the Ca(2+) channel antagonist Cd(2+). Simulated DBS also increased the excitability of thalamic cells in the presence of glutamate receptor blockade, although this non-synaptic effect induced no spontaneous firing such as that found in subthalamic nucleus neurones. Our data suggest that high-frequency stimulation when applied in the ventral thalamus can rapidly disrupt local synaptic function and neuronal firing thereby leading to a 'functional deafferentation' and/or 'functional inactivation'. These mechanisms, driven primarily by synaptic activation, help to explain the paradox that lesions, muscimol and DBS in thalamus all effectively stop tremor.  (+info)

Electron microscopy of tissue adherent to explanted electrodes in dystonia and Parkinson's disease. (2/725)

Deep brain stimulation (DBS) is used to treat a variety of severe medically intractable movement disorders, including Parkinson's disease, tremor and dystonia. There have been few studies examining the effect of chronic DBS on the brains of Parkinson's disease patients. Most of these post mortem studies concluded that chronic DBS caused mild gliosis around the lead track and did not damage brain tissue. There have been no similar histopathological studies on brains from dystonic patients who have undergone DBS. In this study, our objective was to discover whether tissue would be attached to DBS electrodes removed from patients for routine clinical reasons. We hoped that by examining explanted DBS electrodes using scanning (SEM) and/or transmission (TEM) electron microscopy we might visualize any attached tissue and thus understand the electrode-human brain tissue interaction more accurately. Initially, SEM was performed on one control DBS electrode that had not been implanted. Then 21 (one subthalamic nucleus and 20 globus pallidus internus) explanted DBS electrodes were prepared, after fixation in 3% glutaraldehyde, for SEM (n = 9) or TEM (n = 10), or both (n = 2), according to departmental protocol. The electrodes were sourced from two patients with Parkinson's disease, one with myoclonic dystonia, two with cervical dystonia and five with primary generalized dystonia, and had been in situ for 11 and 31 months (Parkinson's disease), 16 months (myoclonic dystonia), 14 and 24 months (cervical dystonia) and 3-24 months (primary generalized dystonia). Our results showed that a foreign body multinucleate giant cell-type reaction was present in all TEM samples and in SEM samples, prewashed to remove surface blood and fibrin, regardless of the diagnosis. Some of the giant cells were >100 microm in diameter and might have originated from either fusion of parenchymal microglia, resident perivascular macrophage precursors and/or monocytes/macrophages invading from the blood stream. The presence of mononuclear macrophages containing lysosomes and sometimes having conspicuous filopodia was detected by TEM. Both types of cell contained highly electron-dense inclusions, which probably represent phagocytosed material. Similar material, the exact nature of which is unknown, was also seen in the vicinity of these cells. This reaction was present irrespective of the duration of implantation and may be a response to the polyurethane component of the electrodes' surface coat. These findings may be relevant to our understanding of the time course of the clinical response to DBS in Parkinson's disease and various forms of dystonia, as well as contributing to the design characteristics of future DBS electrodes.  (+info)

Dorsal posterior parietal rTMS affects voluntary orienting of visuospatial attention. (3/725)

Patients with lesions in posterior parietal cortex (PPC) are relatively unimpaired in voluntarily directing visual attention to different spatial locations, while many neuroimaging studies in healthy subjects suggest dorsal PPC involvement in this function. We used an offline repetitive transcranial magnetic stimulation (rTMS) protocol to study this issue further. Ten healthy participants performed a cue-target paradigm. Cues prompted covert orienting of spatial attention under voluntary control to either a left or right visual field position. Targets were flashed subsequently at the cued or uncued location, or bilaterally. Following rTMS over right dorsal PPC, (i) the benefit for target detection at cued versus uncued positions was preserved irrespective of cueing direction (left- or rightward), but (ii) leftward cueing was associated with a global impairment in target detection, at all target locations. This reveals that leftward orienting was still possible after right dorsal PPC stimulation, albeit at an increased overall cost for target detection. In addition, rTMS (iii) impaired left, but (iv) enhanced right target detection after rightward cueing. The finding of a global drop in target detection during leftward orienting with a spared, relative detection benefit at the cued (left) location (i-ii) suggests that right dorsal PPC plays a subsidiary rather than pivotal role in voluntary spatial orienting. This finding reconciles seemingly conflicting results from patients and neuroimaging studies. The finding of attentional inhibition and enhancement occurring contra- and ipsilaterally to the stimulation site (iii-iv) supports the view that spatial attention bias can be selectively modulated through rTMS, which has proven useful to transiently reduce visual hemispatial neglect.  (+info)

Microstimulation of the superior colliculus focuses attention without moving the eyes. (4/725)

The superior colliculus (SC) is part of a network of brain areas that directs saccadic eye movements, overtly shifting both gaze and attention from position to position, in space. Here, we seek direct evidence that the SC also contributes to the control of covert spatial attention, a process that focuses attention on a region of space different from the point of gaze. While requiring monkeys to keep their gaze fixed, we tested whether microstimulation of a specific location in the SC spatial map would enhance visual performance at the corresponding region of space, a diagnostic measure of covert attention. We find that microstimulation improves performance in a spatially selective manner: thresholds decrease at the location in visual space represented by the stimulated SC site, but not at a control location in the opposite hemifield. Our data provide direct evidence that the SC contributes to the control of covert spatial attention.  (+info)

Different patterns of medication change after subthalamic or pallidal stimulation for Parkinson's disease: target related effect or selection bias? (5/725)

BACKGROUND: Bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) is favoured over bilateral globus pallidus internus (Gpi) DBS for symptomatic treatment of advanced Parkinson's disease (PD) due to the possibility of reducing medication, despite lack of definitive comparative evidence. OBJECTIVE: To analyse outcomes after one year of bilateral Gpi or STN DBS, with consideration of influence of selection bias on the pattern of postsurgical medication change. METHODS: The first patients to undergo bilateral Gpi (n = 10) or STN (n = 10) DBS at our centre were studied. They were assessed presurgically and one year after surgery (CAPIT protocol). RESULTS: Before surgery the Gpi DBS group had more dyskinesias and received lower doses of medication. At one year, mean reduction in UPDRS off medication score was 35% and 39% in the Gpi and STN groups, respectively (non-significant difference). Dyskinesias reduced in proportion to presurgical severity. The levodopa equivalent dose was significantly reduced only in the STN group (24%). This study high-lights the absence of significant differences between the groups in clinical scales and medication dose at one year. In the multivariate analysis of predictive factors for off-state motor improvement, the presurgical levodopa equivalent dose showed a direct relation in the STN and an inverse relation in the Gpi group. CONCLUSION: Differences in the patterns of medication change after Gpi and STN DBS may be partly due to a patient selection bias. Both procedures may be equally useful for different subgroups of patients with advanced PD, Gpi DBS especially for patients with lower threshold for dyskinesia.  (+info)

Subthalamic nucleus stimulation in tremor dominant parkinsonian patients with previous thalamic surgery. (6/725)

Before the introduction of high frequency stimulation of the subthalamic nucleus (STN), many disabled tremor dominant parkinsonian patients underwent lesioning or chronic electrical stimulation of the thalamus. We studied the effects of STN stimulation in patients with previous ventral intermediate nucleus (VIM) surgery whose motor state worsened. Fifteen parkinsonian patients were included in this study: nine with unilateral and two with bilateral VIM stimulation, three with unilateral thalamotomy, and one with both unilateral thalamotomy and contralateral VIM stimulation. The clinical evaluation consisted of a formal motor assessment using the Unified Parkinson's Disease Rating Scale (UPDRS) and neuropsychological tests encompassing a 50 point frontal scale, the Mattis Dementia Rating Scale, and the Beck Depression Inventory. The first surgical procedure was performed a mean (SD) of 8 (5) years after the onset of disease. STN implantation was carried out 10 (4) years later, and duration of follow up after beginning STN stimulation was 24 (20) months. The UPDRS motor score, tremor score, difficulties in performance of activities of daily living, and levodopa equivalent daily dose significantly decreased after STN stimulation. Neither axial symptoms nor neuropsychological status significantly worsened after the implantation of the STN electrodes. The parkinsonian motor state is greatly improved by bilateral STN stimulation even in patients with previous thalamic surgery, and STN stimulation is more effective than VIM stimulation in tremor dominant parkinsonian patients.  (+info)

Comparisons between pharmacologically and Edinger-Westphal-stimulated accommodation in rhesus monkeys. (7/725)

PURPOSE: Accommodation results in increased lens thickness and lens surface curvatures. Previous studies suggest that lens biometric accommodative changes are different with pharmacological and voluntary accommodation. In this study, refractive and biometric changes during Edinger-Westphal (EW) and pharmacologically stimulated accommodation in rhesus monkeys were compared. METHODS: Accommodation was stimulated by an indwelling permanent electrode in the EW nucleus of the midbrain in one eye each of four rhesus monkeys. Dynamic refractive changes were measured with infrared photorefraction, and lens biometric changes were measured with high-resolution, continuous A-scan ultrasonography for increasing stimulus current amplitudes, including supramaximal current amplitudes. Accommodation was then stimulated pharmacologically and biometry was measured continuously for 30 minutes. RESULTS: During EW-stimulated accommodation, lens surfaces move linearly with refraction, with an increase in lens thickness of 0.06 mm/D, an anterior movement of the anterior lens surface of 0.04 mm/D, and a posterior movement of the posterior lens surface of 0.02 mm/D. Peak velocity of accommodation (diopters per second) and lens thickness (in millimeters per second) increased with supramaximal stimulus currents, but without further increase in amplitude or total lens thickness. After carbachol stimulation, there was initially an anterior movement of the anterior lens surface and a posterior movement of the posterior lens surface; but by 30 minutes, there was an overall anterior shift of the lens. CONCLUSIONS: Ocular biometric changes differ with EW and pharmacological stimulation of accommodation. Pharmacological stimulation results in a greater increase in lens thickness, an overall forward movement of the lens and a greater change in dioptric power.  (+info)

Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action. (8/725)

We enrolled six patients suffering from refractory chronic cluster headache in a pilot trial of neurostimulation of the ipsilateral ventroposterior hypothalamus using the stereotactic coordinates published previously. After the varying durations needed to determine optimal stimulation parameters and a mean follow-up of 14.5 months, the clinical outcome is excellent in three patients (two are pain-free; one has fewer than three attacks per month), but unsatisfactory in one patient, who only has had transient remissions. Mean voltage is 3.28 V, diplopia being the major factor limiting its increase. When the stimulator was switched off in one pain-free patient, attacks resumed after 3 months until it was turned on again. In one patient the implantation procedure had to be interrupted because of a panic attack with autonomic disturbances. Another patient died from an intracerebral haemorrhage that developed along the lead tract several hours after surgery; there were no other vascular changes on post-mortem examination. After 1 month, the hypothalamic stimulation induced resistance against the attack-triggering agent nitroglycerin and tended to increase pain thresholds at extracephalic, but not at cephalic, sites. It had no detectable effect on neurohypophyseal hormones or melatonin excretion. We conclude that hypothalamic stimulation has remarkable efficacy in most, but not all, patients with treatment-resistant chronic cluster headache. Its efficacy is not due to a simple analgesic effect or to hormonal changes. Intracerebral haemorrhage cannot be neglected in the risk evaluation of the procedure. Whether it might be more prevalent than in deep-brain stimulation for movement disorders remains to be determined.  (+info)

Neuropsychological changes following deep brain stimulation surgery for Parkinsons disease: Comparisons of treatment at...Neuropsychological changes following deep brain stimulation surgery for Parkinson's disease: Comparisons of treatment at...
TY - JOUR. T1 - Neuropsychological changes following deep brain stimulation surgery for Parkinsons disease. T2 - Comparisons of treatment at pallidal and subthalamic targets versus best medical therapy. AU - Rothlind, Johannes C.. AU - York, Michele K.. AU - Carlson, Kim. AU - Luo, Ping. AU - Marks, William J.. AU - Weaver, Frances M.. AU - Stern, Matthew. AU - Follett, Kenneth. AU - Reda, Domenic. AU - Chairpersons, K. F.. AU - Ippolito, Dolores. AU - Stoner, Gatana. AU - Barnett, Tammy. AU - Bukowski, Ken. AU - De Nicolo, Rosemarie. AU - Hur, Kwan. AU - Jimenez, Joyce. AU - Motyka, Jan. AU - Simon, Theresa. AU - Thakkar, Bharat. AU - Woolson, Robert. AU - Fye, Carol. AU - Gagne, William. AU - Harris, Crystal. AU - Heemskerk, Jill. AU - Moy, Claudia. AU - Sheehy, Paul. AU - OLeary, Timothy. AU - Huang, Grant D.. AU - Fiore, Louis. AU - Hall, Robert. AU - Stroupe, Kevin. AU - Burchiel, Kim. AU - Koller, William. AU - Pahwa, Rajesh. AU - Sagher, Oren. AU - Bakay, Roy. AU - Chappell, Rick. AU - ...
The Seizure and Cognitive Outcome of Anterior Thalamic Nucleus Deep Brain Stimulation for Patients with Intractable EpilepsyThe Seizure and Cognitive Outcome of Anterior Thalamic Nucleus Deep Brain Stimulation for Patients with Intractable Epilepsy
... , Yuguang Guan, Sichang Chen, Yao Zhang, Changqing Liu,
MEG can map short and long-term changes in brain activity following deep brain stimulation for chronic pain. - Nuffield...MEG can map short and long-term changes in brain activity following deep brain stimulation for chronic pain. - Nuffield...
Deep brain stimulation (DBS) has been shown to be clinically effective for some forms of treatment-resistant chronic pain, but the precise mechanisms of action are not well understood. Here, we present an analysis of magnetoencephalography (MEG) data from a patient with whole-body chronic pain, in order to investigate changes in neural activity induced by DBS for pain relief over both short- and long-term. This patient is one of the few cases treated using DBS of the anterior cingulate cortex (ACC). We demonstrate that a novel method, null-beamforming, can be used to localise accurately brain activity despite the artefacts caused by the presence of DBS electrodes and stimulus pulses. The accuracy of our source localisation was verified by correlating the predicted DBS electrode positions with their actual positions. Using this beamforming method, we examined changes in whole-brain activity comparing pain relief achieved with deep brain stimulation (DBS ON) and compared with pain experienced with no
Deep Brain Stimulation Devices Market for Parkinsons disease Expected to Reach USD 9.4 Billion Globally in 2019Deep Brain Stimulation Devices Market for Parkinson's disease Expected to Reach USD 9.4 Billion Globally in 2019
According to a new market report published by Transparency Market Research "Deep Brain Stimulation Devices Market for Parkinsons Disease (North America, Europe, Asia-Pacific and Latin America)- Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019," the global deep brain stimulation devices market was valued at USD 4.5 billion in 2012 and is expected to grow at a CAGR of 11.0% from 2013 to 2019, to reach an estimated value of USD 9.4 billion in 2019.. Browse Global Deep Brain Stimulation Devices Market Report with Full TOC at http://www.transparencymarketresearch.com/deep-brain-stimulator-market.html. Rising number of neurological disorders such ischemic stroke, Alzheimers disease, essential tremors, trauma and especially Parkinsonism are primary factors responsible for the growth of deep brain stimulation devices market. Parkinsons disease is the second most common chronic and progressive neurodegenerative disorder characterized by postural instability, ...
Deep Brain Stimulation May Help With Driving For People With Parkinsons Disease - RedorbitDeep Brain Stimulation May Help With Driving For People With Parkinson's Disease - Redorbit
Deep brain stimulation may have a beneficial effect on driving ability for people with Parkinsons disease, according to a new study published in the December 18, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology. Deep brain stimulation uses a surgical implant similar to a pacemaker to send electrical impulses to the brain.. "Up until now, we werent sure how deep brain stimulation would affect driving," said study author Carsten Buhmann, MD, of University Medical Center Hamburg-Eppendorf in Hamburg, Germany. "On the one hand, it might enhance driving ability by improving the motor problems which occur with Parkinsons disease, but on the other hand, it might hamper driving because it potentially causes a decline in executive cognitive skills.". The study involved 23 people who had deep brain stimulators, 21 people with Parkinsons disease who did not have stimulators and 21 people who did not have Parkinsons disease. All of the participants had been ...
Neuropsychological changes following deep brain stimulation surgery for Parkinsons disease: comparisons of treatment at...Neuropsychological changes following deep brain stimulation surgery for Parkinson's disease: comparisons of treatment at...
Results Comparison of the two DBS targets revealed few significant group differences. STN DBS was associated with greater mean reductions on some measures of processing speed, only one of which was statistically significant in comparison with stimulation of GPi. GPi DBS was associated with lower mean performance on one measure of learning and memory that requires mental control and cognitive flexibility. Compared to the group receiving BMT, the combined DBS group had significantly greater mean reductions at 6-month follow-up in performance on multiple measures of processing speed and working memory. After calculating thresholds for statistically reliable change from data obtained from the BMT group, the combined DBS group also displayed higher rates of decline in neuropsychological test performance. Among study completers, 18 (11%) study participants receiving DBS displayed reliable decline by multiple indicators in two or more cognitive domains, a significantly higher rate than in the BMT group ...
Analysis of Visual-Motor Task Electrophysiological Activity During Deep Brain Stimulation for Treatment-Resistant Movement...Analysis of Visual-Motor Task Electrophysiological Activity During Deep Brain Stimulation for Treatment-Resistant Movement...
Objective:. The objective of this pilot study is to characterize the abnormal neuronal firing patterns of basal ganglia and thalamic neurons and those in the premotor cortex in patients with treatment-resistant movement disorders undergoing deep brain stimulation (DBS) surgery. Neuronal activity will be studied in a decision-making task guided by reward. Secondary objectives will involve study of how activity in the brain is modulated in such a task and how DBS can influence the cerebral activity related to decision-making.. Study population:. Fifteen adult patients with treatment-resistant movement disorders (Essential tremor or Parkinson s disease) who are undergoing deep brain stimulation surgery at Suburban Hospital, Bethesda, Maryland, will be studied.. Design:. This is a physiology study of medically refractory patients who have been scheduled for implantation of a deep brain stimulation device into basal ganglia or thalamic structures. Prior to surgery, patients will learn a rewarded ...
Analysis of Visual-Motor Task Electrophysiological Activity During Deep Brain Stimulation for Treatment-Resistant Movement...Analysis of Visual-Motor Task Electrophysiological Activity During Deep Brain Stimulation for Treatment-Resistant Movement...
Objective:. The objective of this pilot study is to characterize the abnormal neuronal firing patterns of basal ganglia and thalamic neurons and those in the premotor cortex in patients with treatment-resistant movement disorders undergoing deep brain stimulation (DBS) surgery. Neuronal activity will be studied in a decision-making task guided by reward. Secondary objectives will involve study of how activity in the brain is modulated in such a task and how DBS can influence the cerebral activity related to decision-making.. Study population:. Fifteen adult patients with treatment-resistant movement disorders (Essential tremor or Parkinson s disease) who are undergoing deep brain stimulation surgery at Suburban Hospital, Bethesda, Maryland, will be studied.. Design:. This is a physiology study of medically refractory patients who have been scheduled for implantation of a deep brain stimulation device into basal ganglia or thalamic structures. Prior to surgery, patients will learn a rewarded ...
Deep brain stimulation suppresses pallidal low frequency activity in patients with phasic dystonic movements. - Oxford...Deep brain stimulation suppresses pallidal low frequency activity in patients with phasic dystonic movements. - Oxford...
Deep brain stimulation of the globus pallidus internus alleviates involuntary movements in patients with dystonia. However, the mechanism is still not entirely understood. One hypothesis is that deep brain stimulation suppresses abnormally enhanced synchronized oscillatory activity within the motor cortico-basal ganglia network. Here, we explore deep brain stimulation-induced modulation of pathological low frequency (4-12 Hz) pallidal activity that has been described in local field potential recordings in patients with dystonia. Therefore, local field potentials were recorded from 16 hemispheres in 12 patients undergoing deep brain stimulation for severe dystonia using a specially designed amplifier allowing simultaneous high frequency stimulation at therapeutic parameter settings and local field potential recordings. For coherence analysis electroencephalographic activity (EEG) over motor areas and electromyographic activity (EMG) from affected neck muscles were recorded before and immediately after
Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinsons Disease Patients:...Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson's Disease Patients:...
Parkinsons Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinsons disease.
Brain Sciences | Free Full-Text | Deep Brain Stimulation: In Search of Reliable Instruments for Assessing Complex Personality...Brain Sciences | Free Full-Text | Deep Brain Stimulation: In Search of Reliable Instruments for Assessing Complex Personality...
During the last 25 years, more than 100,000 patients have been treated with Deep Brain Stimulation (DBS). While human clinical and animal preclinical research has shed light on the complex brain-signaling disturbances that underpin e.g., Parkinsons disease (PD), less information is available when it comes to complex psychosocial changes following DBS interventions. In this contribution, we propose to more thoroughly investigate complex personality-related changes following deep brain stimulation through refined and reliable instruments in order to help patients and their relatives in the post-surgery phase. By pursuing this goal, we first outline the clinical importance DBS has attained followed by discussing problematic and undesired non-motor problems that accompany some DBS interventions. After providing a brief definition of complex changes, we move on by outlining the measurement problem complex changes relating to non-motor symptoms currently are associated with. The latter circumstance
New Deep Brain Stimulation Device Shows Promising Results - Healthcanal.com : Healthcanal.comNew Deep Brain Stimulation Device Shows Promising Results - Healthcanal.com : Healthcanal.com
The study, whose co-authors included George Mandybur, MD, an associate professor of neurosurgery at the University of Cincinnati (UC) College of Medicine and Mayfield Clinic neurosurgeon, and Fredy Revilla, MD, an associate professor of neurology and UC Health neurologist, was published Jan. 11, 2012, in the online edition of Lancet Neurology. Mandybur and Revilla are members of the James J. and Joan A. Gardner Center for Parkinsons Disease and Movement Disorders at the UC Neuroscience Institute, a specialty center within UC Health. Principal investigator of the study was Michael Okun, MD, a neurologist and co-director of the Center for Movement Disorders and Neurorestoration at the University of Florida College of Medicine. Deep brain stimulation (DBS) devices stimulate the subthalamic nucleus deep within the brain. Deep brain stimulation surgery has been shown to reduce symptoms of Parkinsons and to improve quality of life. The Lancet Neurology study examined the new Libra and LibraXP ...
Deep Brain Stimulation May Control Hard-to-Treat Blood Pressure - CakehealthDeep Brain Stimulation May Control Hard-to-Treat Blood Pressure - Cakehealth
Deep brain stimulation may have benefits beyond the treatment of brain disorders - it may provide an alternative therapy for people with high blood pressure patients who arent able to treat their condition with drugs, according to a new study.. The report describes the case of a 55-year-old man who underwent deep brain stimulation - which uses a surgically implanted device to send electrical pulses into the brain - as treatment for chronic pain. The man also had high blood pressure, or hypertension , which had stayed elevated despite previous treatments, including being medicated with four prescription drugs simultaneously.. Though the deep brain stimulation did little to treat the patients pain, it lowered his blood pressure enough for him to quit taking his blood pressure medications for nearly three years, the researchers said.. While the findings are preliminary, and require validation in a larger number of patients, they are exciting, said William T. Abraham, director of the division of ...
A history of deep brain stimulation: Technological innovation and the role of clinical assessment tools - Research Database,...A history of deep brain stimulation: Technological innovation and the role of clinical assessment tools - Research Database,...
Deep brain stimulation involves using a pacemaker-like device to deliver constant electrical stimulation to problematic areas within the brain. It has been used to treat over 40,000 people with Parkinsons disease and essential tremor worldwide and is currently undergoing clinical trials as a treatment for depression and obsessive-compulsive disorder. This article will provide an historical account of deep brain stimulation in order to illustrate the plurality of interests involved in the development and stabilization of deep brain stimulation technology. Using Latours notion of immutable mobiles, this article will illustrate the importance of clinical assessment tools in shaping technological development in the era of medical device regulation. Given that such tools can serve commercial and professional interests, this article suggests that it is necessary to scrutinise their application in research contexts to ensure that they capture clinical changes that are meaningful for patients and ...
Best Deep Brain Stimulation For Parkinsons Disease Doctors in India | Doctors for Deep Brain Stimulation For Parkinsons...Best Deep Brain Stimulation For Parkinson's Disease Doctors in India | Doctors for Deep Brain Stimulation For Parkinson's...
Looking for the list of best Deep Brain Stimulation For Parkinson's Disease Doctors in India within your budget. Contact Us at Vaidam for the right guidance and list of Deep Brain Stimulation For Parkinson's Disease Doctors in India
Accuracy of stimulating electrode placement in paediatric pallidal deep brain stimulation for primary and secondary dystonia. |...Accuracy of stimulating electrode placement in paediatric pallidal deep brain stimulation for primary and secondary dystonia. |...
BACKGROUND: Accuracy of electrode placement is an important determinant of outcome following deep brain stimulation (DBS) surgery. Data on accuracy of electrode placement into the globus pallidum interna (GPi) in paediatric patients is limited, particularly those with non-primary dystonia who often have smaller GPi. Pallidal DBS is known to be more effective in the treatment of primary dystonia compared with secondary dystonia.
Twiddlers syndrome in a patient with a deep brain stimulation device for generalized dystonia. - Nuffield Department of...Twiddler's syndrome in a patient with a deep brain stimulation device for generalized dystonia. - Nuffield Department of...
Deep brain stimulation (DBS) is the technique of neurostimulation of deep brain structures for the treatment of conditions such as essential tremor, dystonia, Parkinsons disease and chronic pain syndromes. The procedure uses implanted deep brain stimulation electrodes connected to extension leads and an implantable pulse generator (IPG). Hardware failure related to the DBS procedure is not infrequent, and includes electrode migration and disconnection. We describe a patient who received bilateral globus pallidus internus DBS for dystonia with initially good clinical response, but the device eventually failed. Radiographs showed multiple twisting of the extension leads with disconnection from the brain electrodes and a diagnosis of Twiddlers syndrome was made. Twiddlers syndrome was first described in patients with cardiac pacemakers. Patients with mental disability, elderly and obese patients are at increased risk. Twiddlers syndrome should be suspected whenever there is a failure of the DBS device
Cataract surgery under topical anesthesia in a patient with Parkinson disease and deep brain stimulation: a report of...Cataract surgery under topical anesthesia in a patient with Parkinson disease and deep brain stimulation: a report of...
Deep brain stimulation provides benefits for people with Parkinson disease by managing some of their complications. None of the few reports in the current literature establishes the functionality of deep brain stimulation when activated during phacoemulsification.A 70-year-old woman with subthalamic deep brain stimulator (DBS) for advanced Parkinson disease was referred to our center for cataract surgery. To evaluate any possible interference between ultrasounds and the DBS, we registered the impedance of the electrodes before and after surgery.The patient underwent uneventful phacoemulsification of her right eye under topical anesthesia with her internal pulse generator device activated. During the surgical procedure, all potential variations of the impedance of the electrodes were recorded.This report demonstrates that phacoemulsification under topical anesthesia is a feasible procedure in patients with DBS, showing no interference between the ultrasounds and the internal pulse ...
https://www.medicalnewstoday.com/releases/291468.phphttps://www.medicalnewstoday.com/releases/291468.php
Patients with Parkinson disease who experienced pain before undergoing subthalamic nucleus deep brain stimulation (STN DBS) had that pain improved or eliminated at eight years after surgery...
Pedunculopontine nucleus deep brain stimulation produces sustained improvement in primary progressive freezing of gait |...Pedunculopontine nucleus deep brain stimulation produces sustained improvement in primary progressive freezing of gait |...
Results The PPFG patient exhibited a robust improvement in gait and posture following PPN-DBS. When PPN stimulation was deactivated, postural stability and gait skills declined to pre-DBS levels, and fluoro-2-deoxy-d-glucose positron emission tomography revealed hypoactive cerebellar and brainstem regions, which significantly normalised when PPN stimulation was reactivated. ...
Browse by Authors and Editors - Nottingham ePrintsBrowse by Authors and Editors - Nottingham ePrints
Steel, David Anthony and Basu, Surajit (2017) Does trajectory matter? A study looking into the relationship of trajectory with target engagement and error accommodation in subthalamic nucleus deep brain stimulation. Acta Neurochirurgica . ISSN 0942-0940 Fletcher, Kimberley J. and das Nair, Roshan and Macniven, Jamie A. and Basu, Surajit and Byrne, Paul (2012) An interpretative phenomenological analysis of the patient experience of awake craniotomy: brain tumour diagnosis to discharge. British Journal of Health Psychology, 17 (4). pp. 828-842. ISSN 2044-8287 ...
Deep Brain Stimulation Offers Hope for MCSDeep Brain Stimulation Offers Hope for MCS
A 38-year old man in a minimally conscious state (MCS) from a closed head injury experienced improvement following deep brain stimulation of the midline and
Reflections on using Deep Brain Stimulation (DBS) to treat neuropsychiatric disorders - ECR CommunityReflections on using Deep Brain Stimulation (DBS) to treat neuropsychiatric disorders - ECR Community
By Daniel Albaugh. One of my most fascinating experiences as a doctoral student of neuroscience began with an early morning trip to the university hospital. Upon arrival, my laboratory colleagues and I met with one of the clinical neurologists, who introduced us to a patient suffering from advanced Parkinsons Disease. Medications were no longer working effectively, and the patients motor symptoms were severe and debilitating. The day that we arrived, the patient was to have electrodes implanted deep into the brain circuitry that was misbehaving in his disease, the first step in a revolutionary therapeutic approach known as deep brain stimulation (DBS).. What is Deep Brain Stimulation?. DBS is an increasingly well-utilized therapeutic tool for many neurological diseases, predominantly movement disorders. With this therapy, high frequency electrical stimulation is chronically delivered to a target brain region, powered by a battery source implanted near the patients clavicle. In Parkinsons ...
Gender distribution of patients with Parkinsons disease treated with subthalamic deep brain stimulation : a review of the 2000...Gender distribution of patients with Parkinson's disease treated with subthalamic deep brain stimulation : a review of the 2000...
Purpose: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been the mainstream surgical procedure for advanced Parkinsons disease (PD) during the last decade. Reports from a few individual centres have hinted that women who receive STN DBS are under-represented. We aimed to evaluate the gender distribution of patients with PD who had received STN DBS during the last ten years, and to discuss the findings in relation to studies on gender prevalence of PD.. Methods: A search of the PubMed database of clinical papers in English language related to STN DBS between 2000 and 2009 was conducted. Care was taken to minimize redundancies in reporting of published patients. The proportion of men and women were expressed in total and according to pre-defined geographic regions.. Results: One hundred and thirty five papers were eligible for review. The gender of the patients was specified in 119 papers on a total of 3880 patients, of which 63% were men. According to geographic origin of ...
Unexpected Complications of Novel Deep Brain Stimulation Treatments: Ethical Issues and Clinical Recommendations. - Nuffield...Unexpected Complications of Novel Deep Brain Stimulation Treatments: Ethical Issues and Clinical Recommendations. - Nuffield...
BACKGROUND: Innovative neurosurgical treatments present a number of known risks, the natures and probabilities of which can be adequately communicated to patients via the standard procedures governing obtaining informed consent. However, due to their novelty, these treatments also come with unknown risks, which require an augmented approach to obtaining informed consent. OBJECTIVE: This paper aims to discuss and provide concrete procedural guidance on the ethical issues raised by serious unexpected complications of novel deep brain stimulation treatments. APPROACH: We illustrate our analysis using a case study of the unexpected development of recurrent stereotyped events in patients following the use of deep brain stimulation (DBS) to treat severe chronic pain. Examining these unexpected complications in light of medical ethical principles, we argue that serious complications of novel DBS treatments do not necessarily make it unethical to offer the intervention to eligible patients. However, the
Deep Brain Stimulation in Metro Hospital Thane West, Mumbai - View Cost, Book Appointment, Consult OnlineDeep Brain Stimulation in Metro Hospital Thane West, Mumbai - View Cost, Book Appointment, Consult Online
Doctors for Deep Brain Stimulation in Metro Hospital Thane West, Mumbai. Find Doctors Near You, Book Doctors Appointment, Consult Online, View Cost for Deep Brain Stimulation in Metro Hospital Thane West, Mumbai | Lybrate
Are patients sedated during deep brain stimulation surgery? | Parkinsons Disease Treatment - SharecareAre patients sedated during deep brain stimulation surgery? | Parkinson's Disease Treatment - Sharecare
The goal of deep brain stimulation, which is generally referred to as DBS, is to improve function and quality of life. That is best achieved by being
Deep Brain Stimulation Surgery for Parkinsons Disease - Our experience over 10 years | M K Lee Neuro ClinicDeep Brain Stimulation Surgery for Parkinson's Disease - Our experience over 10 years | M K Lee Neuro Clinic
malaysian experience in deep brain stimulation for parkinson s disease long term results pdfView more ebooks on ebookbrowse.com |/div|
Deep brain stimulation surgery may be effective treatment for obesityDeep brain stimulation surgery may be effective treatment for obesity
Researchers have found that deep brain stimulation reduces binge eating in mice, suggesting that this surgery, which is approved for treatment of certain neurologic and psychiatric disorders, may also be an effective therapy for obesity.
Post-Traumatic Tremor and Thalamic Deep Brain Stimulation: Evidence for Use of Diffusion Tensor Imaging. - Nuffield Department...Post-Traumatic Tremor and Thalamic Deep Brain Stimulation: Evidence for Use of Diffusion Tensor Imaging. - Nuffield Department...
BACKGROUND: Deep brain stimulation (DBS) is a well-established treatment to reduce tremor, notably in Parkinson disease. DBS may also be effective in post-traumatic tremor, one of the most common movement disorders caused by head injury. However, the cohorts of patients often have multiple lesions that may impact the outcome depending on which fiber tracts are affected. CASE DESCRIPTION: A 20-year-old man presented after road traffic accident with severe closed head injury and polytrauma. Computed tomography scan showed left frontal and basal ganglia hemorrhagic contusions and intraventricular hemorrhage. A disabling tremor evolved in step with motor recovery. Despite high-intensity signals in the intended thalamic target, a visual analysis of the preoperative diffusion tensor imaging revealed preservation of connectivity of the intended target, ventralis oralis posterior thalamic nucleus (VOP). This was confirmed by the postoperative tractography study presented here. DBS of the VOP/zona incerta was
Neurophysiology of Deep Brain StimulationNeurophysiology of Deep Brain Stimulation
We review the data concerning the neurophysiology of deep brain stimulation (DBS) in humans, especially in reference to Parkinsons disease. The electric field generated by DBS interacts with the brain in complex ways, and several variables could influence the DBS-induced biophysical and clinical effects. The neurophysiology of DBS comprises the DBS-induced effects per se as well as neurophysiological studies designed to record electrical activity directly from the basal ganglia (single-unit or local field potential) through the electrodes implanted for DBS. In the subthalamic nucleus, DBS locally excites and concurrently inhibits at single-unit level, synchronizes low-frequency activity, and desynchronizes beta activity and also induces neurochemical changes in cyclic guanosine monophosphate (cGMP) and GABA concentrations. DBS-induced effects at system level can be studied through evoked potentials, autonomic tests, spinal cord segmental system, motor cortical and brainstem excitability, gait, ...
Frontiers | Localization of Deep Brain Stimulation Contacts Using Corticospinal/Corticobulbar Tracts Stimulation | NeurologyFrontiers | Localization of Deep Brain Stimulation Contacts Using Corticospinal/Corticobulbar Tracts Stimulation | Neurology
Abstract1. Background Successful deep brain stimulation (DBS) in Parkinsons disease (PD) requires optimal electrode placement. One technique of intraoperative electrode testing is determination of stimulation thresholds inducing corticospinal/corticobulbar tracts (CSBT) motor contractions. 2. ObjectiveThis study aims to analyze correlations between DBS electrode distance to CSBT and contraction thresholds, with either visual or electromyographic (EMG) detection, to establish an intraoperative tool devoted to ensure safe distance of the electrode to the CSBT. 3. MethodsTwelve PD patients with subthalamic nucleus DBS participated. Thresholds of muscular contractions were assessed clinically and with EMG, for 3 different sets of stimulation parameters, all monopolar: 130Hz high frequency stimulation (HFS); 2Hz low frequency stimulation with either 60 or 210µs (LFS-60, LFS-210). The anatomical distance of electrode contacts to CSBT was measured from fused CT-MRI. 4. ResultsThe best linear correlation was
Realization of Fricatives in Patients with Parkinsons Disease Treated with Deep Brain Stimulation in the Subthalamic Nucleus...Realization of Fricatives in Patients with Parkinson's Disease Treated with Deep Brain Stimulation in the Subthalamic Nucleus...
Background. In advanced Parkinsons disease (PD) the motor symptoms can be treated with deep brain stimulation (DBS). Subthalamic nucleus (STN) has been the most common target and caudal zona incerta (cZi) is a more recent target for stimulation. Stimulation in both of these targets has proved to be positive for the motor symptoms but there is no consensus about how DBS affects the speech and the articulation.. Aim. The aim of this study was to investigate how fricatives are realized within patients suffering from PD treated with DBS in STN or cZi.. Method. 9 patients stimulated in STN and 10 patients stimulated in cZi were recorded reading a shorter text. The recordings were made preoperatively (Pre) and 12 months after surgery with the stimulation switched off (sOff) and on (sOn). From the recordings the fricatives were extracted and assessed in a blinded and randomized procedure.. Results. For the patients stimulated in cZi the target fricative /s/ had significant lower correct realizations ...
Deep Brain StimulationDeep Brain Stimulation
... surgery can relieve the tremors linked to multiple sclerosis (MS). Learn more about the procedure and its purpose, risks, and benefits.
Postmortem analysis following 71 months of deep brain stimulation of the subthalamic nucleus for Parkinson disease in: Journal...Postmortem analysis following 71 months of deep brain stimulation of the subthalamic nucleus for Parkinson disease in: Journal...
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a clinically effective neurosurgical treatment for Parkinson disease. Tissue reaction to chronic DBS therapy and the definitive location of active stimulation contacts are best studied on a postmortem basis in patients who have undergone DBS. The authors report the postmortem analysis of STN DBS following 5 years and 11 months of effective chronic stimulation including the histologically verified location of the active contacts associated with bilateral implants. They also describe tissue response to intraoperative test passes with recording microelectrodes and stimulating semimacroelectrodes. The results indicated that 1) the neural tissue surrounding active and nonactive contacts responds similarly, with a thin glial capsule and foreign-body giant cell reaction surrounding the leads as well as piloid gliosis, hemosiderin-laden macrophages, scattered lymphocytes, and Rosenthal fibers; 2) there was evidence of separate tracts in ...
Deep Brain Stimulation for epilepsy: knowledge gained from experimental animal modelsDeep Brain Stimulation for epilepsy: knowledge gained from experimental animal models
article{664720, abstract = {Since the development of Deep Brain Stimulation (DBS) for Parkinsons Disease, DBS has been suggested as a treatment option for various other neurological disorders. Stimulation of deep brain structures for refractory epilepsy appears to be a safe treatment option with promising results. As research on the evaluation and optimization of DBS for refractory epilepsy may be difficult and unethical in patients, studies on animal models of epilepsy are indispensable. Various brain structures and specific nuclei such as the basal ganglia, the cerebellum, the locus coeruleus and temporal lobe structures have been investigated as target areas for DBS. Additionally, a wide variety of stimulation parameters are available, with a range of stimulation frequencies, pulse widths and stimulation intensities. This review provides an overview of the relevant literature on experimental animal studies of DBS for epilepsy. Knowledge gained from animal studies can be used to answer ...
Deep brain stimulation and its effects on Parkinson disease spatiotemp by Greydon Gilmore"Deep brain stimulation and its effects on Parkinson disease spatiotemp" by Greydon Gilmore
Subthalamic (STN) deep brain stimulation (DBS) alleviates common appendicular PD symptoms, such as: tremor, rigidity and bradykinesia. However, the effect STN-DBS has on modulating axial gait features has not been properly quantified objectively. The purpose of the present thesis was to investigate the role STN-DBS plays in modulating specific gait features such as pace, asymmetry, variability, rhythm and postural control. It is hypothesized that axial gait function is regulated predominantly by non-dopaminergic control systems. In the acute immediate post-operative phase a surgical effect, named the microlesion effect (MLE), is thought to produce a transient improvement of appendicular and axial symptoms. It was hypothesized the MLE is a surgical effect, having a non-specific influence on both appendicular and axial symptoms. Following surgical recovery and 6 months of clinically optimized STN-DBS, it was expected that the true STN-DBS effects would be presented. It was hypothesized that STN-DBS plays
Deep Brain Stimulation May Improve Cognition in Dementia, Other Neurodegenerative DiseasesDeep Brain Stimulation May Improve Cognition in Dementia, Other Neurodegenerative Diseases
Researchers will present findings at the AANS Annual Scientific meeting of their studying testing if Intralaminar thalamic deep brain stimulation (ILN-DBS) could have an effect on dementia and other neurodegenerative diseases that cause severe cognitive dysfunction.
Frontiers | Deep Brain Stimulation of the Subthalamic Nucleus Improves Reward-Based Decision-Learning in Parkinsons Disease ...Frontiers | Deep Brain Stimulation of the Subthalamic Nucleus Improves Reward-Based Decision-Learning in Parkinson's Disease ...
Recently, the subthalamic nucleus (STN) has been shown to be critically involved in decision-making, action selection, and motor control. Here we investigate the effect of deep brain stimulation (DBS) of the STN on reward-based decision-learning in patients diagnosed with Parkinsons disease (PD). We determined computational measures of outcome evaluation and reward prediction from PD patients who performed a probabilistic reward-based decision-learning task. In previous work, these measures covaried with activation in the nucleus caudatus (outcome evaluation during the early phases of learning) and the putamen (reward prediction during later phases of learning). We observed that stimulation of the STN motor regions in PD patients served to improve reward-based decision-learning, probably through its effect on activity in frontostriatal motor loops (prominently involving the putamen and, hence, reward prediction). In a subset of relatively younger patients with relatively shorter disease duration, the
Dyspnea as a side effect of subthalamic nucleus deep brain stimulation for Parkinsons disease. - Wellcome Centre for...Dyspnea as a side effect of subthalamic nucleus deep brain stimulation for Parkinson's disease. - Wellcome Centre for...
Bilateral subthalamic nucleus deep brain stimulation for Parkinsons disease improves limb function. Unpublished observations from our clinic noted that some subthalamic nucleus deep brain stimulation patients complain of post-operative dyspnea. Therefore, we designed a prospective, longitudinal study to characterize this in greater depth. We used specific questionnaires to assess dyspnea in patients with electrodes in the subthalamic nucleus (n=13) or ventral intermediate thalamus (n=7). St. Georges Hospital Respiratory Questionnaire symptom subscale scores were greater in subthalamic nucleus patients (median=18.60, interquartile range=40.80) than ventral intermediate thalamus patients (median = 0.00, interquartile range=15.38) at greater than 6 months post-operatively (p|0.05). Several of the subthalamic nucleus patients exhibited functional impairments as judged by the St. Georges Hospital Respiratory Questionnaire impact subscale, the Medical Research Council Dyspnoea Scale, and the Dyspnoea-12
Dyspnea as a side effect of subthalamic nucleus deep brain stimulation for Parkinsons disease. - Oxford NeuroscienceDyspnea as a side effect of subthalamic nucleus deep brain stimulation for Parkinson's disease. - Oxford Neuroscience
Bilateral subthalamic nucleus deep brain stimulation for Parkinsons disease improves limb function. Unpublished observations from our clinic noted that some subthalamic nucleus deep brain stimulation patients complain of post-operative dyspnea. Therefore, we designed a prospective, longitudinal study to characterize this in greater depth. We used specific questionnaires to assess dyspnea in patients with electrodes in the subthalamic nucleus (n=13) or ventral intermediate thalamus (n=7). St. Georges Hospital Respiratory Questionnaire symptom subscale scores were greater in subthalamic nucleus patients (median=18.60, interquartile range=40.80) than ventral intermediate thalamus patients (median = 0.00, interquartile range=15.38) at greater than 6 months post-operatively (p|0.05). Several of the subthalamic nucleus patients exhibited functional impairments as judged by the St. Georges Hospital Respiratory Questionnaire impact subscale, the Medical Research Council Dyspnoea Scale, and the Dyspnoea-12
Advanced research on deep brain stimulation in treating mental disorders (Review)Advanced research on deep brain stimulation in treating mental disorders (Review)
Deep brain stimulation is a method that involves using an electric stimulus on a specific target in the brain with stereotaxis. It is a minimally invasive, safe, adjustable and reversible nerve involvement technology. At present, this technique is widely applied to treat movement disorders and has produced promising effects on mental symptoms, including combined anxiety and depression. Deep brain stimulation has therefore been employed as a novel treatment for depression, obsessive‑compulsive disorder, habituation, Tourettes syndrome, presenile dementia, anorexia nervosa and other refractory mental illnesses. Many encouraging results have been reported. The aim of the present review was to briefly describe the mechanisms, target selection, side effects, ethical arguments and risks associated with deep brain stimulation. Although deep brain stimulation is a developing and promising treatment, a large amount of research is still required to determine its curative effect, and the selection of ...
Deep brain stimulation in a Chinese Tourettes syndrome patient | HKMJDeep brain stimulation in a Chinese Tourette's syndrome patient | HKMJ
A 31-year-old Chinese man with intractable severe, lifelong Tourettes syndrome characterised by forceful self-injurious motor tics and socially embarrassing vocal tics was treated with bilateral deep brain stimulation. Electrodes were implanted into the thalamic targets at the centromedian-parafascicular complex according to Hasslers nomenclature. A dramatic reduction of tics resulted. At 18 months postoperatively, there was an 81% improvement in his total tics count and a 58% improvement in his Yale Global Tic Severity Scale. His modified Rush video scale decreased from 13 to 8 and visual analogue scale from 10 to 3. These data show that bilateral deep brain stimulation of the thalamus can have a favourable immediate effect on severe tics in a selected group of adult patients suffering from intractable Tourettes syndrome and postoperatively the beneficial effects persisted for at least 18 months ...
Most recent papers with the keyword Duffy system | Read by QxMDMost recent papers with the keyword Duffy system | Read by QxMD
Subthalamic nucleus deep brain stimulation (STN DBS) protects dopaminergic neurons of the substantia nigra pars compacta (SNpc) against 6-OHDA and MPTP. We evaluated STN DBS in a parkinsonian model that displays α-synuclein pathology using unilateral, intranigral injections of recombinant adeno-associated virus pseudotype 2/5 to overexpress wildtype human α-synuclein (rAAV2/5 α-syn). A low titer of rAAV2/5 α-syn results in progressive forelimb asymmetry, loss of striatal dopaminergic terminal density and modest loss of SNpc dopamine neurons after eight weeks, corresponding to robust human-Snca expression and no effect on rat-Snca, Th, Bdnf or Trk2 ...
Deep brain stimulation for dystonia. - Department of Physiology, Anatomy and Genetics (DPAG)Deep brain stimulation for dystonia. - Department of Physiology, Anatomy and Genetics (DPAG)
Within the past few years, there has been a renaissance of functional neurosurgery for the treatment of dystonic movement disorders. In particular, deep brain stimulation (DBS) has widened the spectrum of therapeutical options for patients with otherwise intractable dystonia. It has been introduced only with a delay after DBS became an accepted treatment for advanced Parkinson disease (PD). In this overview, the authors summarize the current status of its clinical application in dystonia. Deep brain stimulation for dystonia has been developed from radiofrequency lesioning, but it has replaced the latter largely in most centers. The main target used for primary dystonia is the posteroventral globus pallidus internus (GPi), and its efficacy has been shown in generalized dystonia, segmental dystonia, and complex cervical dystonia. The optimal target for secondary dystonias is still unclear, but some patients appear to benefit more from thalamic stimulation. The improvement of dystonia with chronic DBS
Post-operative progress of dystonia patients following globus pallidus internus deep brain stimulation. - Physiology, Anatomy...Post-operative progress of dystonia patients following globus pallidus internus deep brain stimulation. - Physiology, Anatomy...
In the current era of functional surgery for movement disorders, deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favoured intervention for patients with dystonia. Here we report our results in 20 patients with medically intractable dystonia treated with GPi stimulation. The series comprised 14 patients with generalized dystonia and six with spasmodic torticollis. Although comparisons were limited by differences in their respective neurological rating scales, chronic DBS clearly benefited both patient groups. Data conveying the rate of change in neurological function following intervention are also presented, demonstrating the gradual but progressive and sustained nature of improvement following stimulation of the GPi in dystonic patients.
Post subthalamic area deep brain stimulation for tremors: a mini-review | Translational Neurodegeneration | Full TextPost subthalamic area deep brain stimulation for tremors: a mini-review | Translational Neurodegeneration | Full Text
Deep brain stimulation (DBS) in the thalamic ventrointermediate nucleus (VIM) is the traditional target for the surgical treatment of pharmacologically refractory essential tremor or parkinsonian tremor. Studies in recent years on DBS in posterior subthalamic area (PSA), including the zona incerta and the prelemniscal radiation, have shown promising results in tremor suppression, particularly for those tremors difficult to be well controlled by VIM DBS, such as the proximal postural tremor, distal intention tremor and some cerebellar outflow tremor in various diseases including essential tremor and multiple sclerosis. The adverse effect profile of the PSA DBS is mild and transient, without lasting or striking dysarthria, disequilibrium or tolerance, in contrast to VIM DBS, particularly bilateral DBS. However, the studies on PSA DBS so far are still limited, with a handful of studies on bilateral PSA, and a short follow up duration compared to VIM. More studies are needed for direct comparison of these
Deep brain stimulation for cluster headache. - Nuffield Department of Surgical SciencesDeep brain stimulation for cluster headache. - Nuffield Department of Surgical Sciences
Cluster headache is a severely debilitating disorder that can remain unrelieved by current pharmacotherapy. Alongside ablative neurosurgical procedures, neuromodulatory treatments of deep brain stimulation (DBS) and occipital nerve simulation have emerged in the last few years as effective treatments for medically refractory cluster headaches. Pioneers in the field have sought to publish guidelines for neurosurgical treatment; however, only small case series with limited long-term follow-up have been published. Controversy remains over which surgical treatments are best and in which circumstances to intervene. Here we review current data on neurosurgical interventions for chronic cluster headache focusing upon DBS and occipital nerve stimulation, and discuss the indications for and putative mechanisms of DBS including translational insights from functional neuroimaging, diffusion weighted tractography, magnetoencephalography and invasive neurophysiology.
Reclaimâ„¢ Deep Brain Stimulation (DBS) Therapy for Obsessive-Compulsive Disorder (Humanitarian Use Device) | Weill Cornell Brain...Reclaimâ„¢ Deep Brain Stimulation (DBS) Therapy for Obsessive-Compulsive Disorder (Humanitarian Use Device) | Weill Cornell Brain...
To provide deep brain stimulation therapy to alter pathological functioning of circuitry involved in causing medically-resistant obsessive-compulsive disorder.
Long-term outcome of deep brain stimulation in generalised dystonia: a series of 60 cases. | Foundation Dystonia ResearchLong-term outcome of deep brain stimulation in generalised dystonia: a series of 60 cases. | Foundation Dystonia Research
BACKGROUND: There is solid evidence of the long term efficacy of deep brain stimulation of the globus pallidus pars interna in the treatment of generalised dystonia. However there are conflicting reports concerning whether certain subgroups gain more benefit from treatment than others. We analysed the results of a series of 60 cases to evaluate the effects of previously proposed prognostic factors including dystonia aetiology, dystonia phenotype, age at onset of dystonia, and duration of dystonia prior to treatment.
Deep Brain Stimulation in Tourette SyndromeDeep Brain Stimulation in Tourette Syndrome
... , from Hot Topics in Evaluation, Treatment and Management of Tourette Syndrome and Co-occurring Conditions
Evidence of Deep Brain Stimulation for Obsessive-Compulsive DisorderEvidence of Deep Brain Stimulation for Obsessive-Compulsive Disorder
Patients with obsessive-compulsive disorder who do not respond to other treatments can benefit from deep brain stimulation, supports available research evidence.
Division of Neurotherapeutics - Massachusetts General Hospital, Boston, MADivision of Neurotherapeutics - Massachusetts General Hospital, Boston, MA
Widge, A. S., Zorowitz, S., Link, K., Miller, E. K., Deckersbach, T., Eskandar, E. N., & Dougherty, D. D. (2015). Ventral Capsule/Ventral Striatum Deep Brain Stimulation Does Not Consistently Diminish Occipital Cross-Frequency Coupling. Biological Psychiatry.. Widge, A. S., Arulpragasam, A. R., Deckersbach, T., & Dougherty, D. D. (2015). Deep brain stimulation for psychiatric disorders. Emerging trends in the social and behavioral sciences: An interdisciplinary, searchable, and linkable resource.. Widge, A.S., Deckersbach, T., Eskandar, E. N. & Dougherty, D. D. Deep Brain Stimulation for Treatment-Resistant Psychiatric Illnesses: What Has Gone Wrong and What Should We Do Next? Biological Psychiatry, 2015 Jun 10.. Widge, A. S., & Dougherty, D. D. (2015). Deep Brain Stimulation for Treatment-Refractory Mood and Obsessive-Compulsive Disorders. Current Behavioral Neuroscience Reports, 2(4), 187-197.. Nierenberg, A., Peters, A., Stange, J., Sylvia, L.G., Otto, M.W., Miklowitz, D.J., Dougherty, D.D., ...
Me, Myself and My Brain Implant: Deep Brain Stimulation Raises Questions of Personal Authenticity and Alienation | SpringerLinkMe, Myself and My Brain Implant: Deep Brain Stimulation Raises Questions of Personal Authenticity and Alienation | SpringerLink
In this article, I explore select case studies of Parkinson patients treated with deep brain stimulation (DBS) in light of the notions of alienation and authenticity. While the literature on DBS has s
Deep Brain Stimulation Reduces Rats Cocaine Seeking | National Institute on Drug Abuse (NIDA)Deep Brain Stimulation Reduces Rats' Cocaine Seeking | National Institute on Drug Abuse (NIDA)
Describes results from an animal study involving deep brain stimulation that holds promise as a therapy for severe cocaine addiction.
Deep brain stimulation definition | Drugs.comDeep brain stimulation definition | Drugs.com
Definition of deep brain stimulation. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
U of U Biomedical EngineeringU of U Biomedical Engineering
Patel YA, George A, Dorval AD, White JA, Christini DJ, Butera RJ, Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI). PLoS Comput Biol 2017 May;13(5):e1005430. King NO, Anderson CJ, Dorval AD, Deep brain stimulation exacerbates hypokinetic dysarthria in a rat model of Parkinsons disease. J Neurosci Res 2016 Feb;94(2):128-38. Dorval AD, Muralidharan A, Jensen AL, Baker KB, Vitek JL, Information in pallidal neurons increases with parkinsonian severity. Parkinsonism Relat Disord 2015 Nov;21(11):1355-61. Willsie AC, Dorval AD, Computational Field Shaping for Deep Brain Stimulation With Thousands of Contacts in a Novel Electrode Geometry. Neuromodulation 2015 Oct;18(7):542-50; discussion 550-1. Anderson CJ, Sheppard DT, Huynh R, Anderson DN, Polar CA, Dorval AD, Subthalamic deep brain stimulation reduces pathological information transmission to the thalamus in a rat model of parkinsonism. Front Neural Circuits 2015;9:31. Willsie A, Dorval A, Fabrication and ...
Deep Brain Stimulator For Parkinsons Disease Stock Image Search ResultsDeep Brain Stimulator For Parkinson's Disease Stock Image Search Results
Deep Brain Stimulator For Parkinsons Disease,Medical Illustration database of the best portfolios and stock images now features General and Commercial Illustration and illustrators. 8,000+ image database includes all types of subjects and features the largest directory of medical, science, and nature illustrators and illustration on the web.
Deep Brain Stimulator For Multiple Sclerosis Stock Image Search ResultsDeep Brain Stimulator For Multiple Sclerosis Stock Image Search Results
Deep Brain Stimulator For Multiple Sclerosis,Medical Illustration database of the best portfolios and stock images now features General and Commercial Illustration and illustrators. 8,000+ image database includes all types of subjects and features the largest directory of medical, science, and nature illustrators and illustration on the web.
Deep Brain Stimulators Market To Witness Growth Owing To Rising Demand For Cost Effective And Minimally Invasive Surgical...Deep Brain Stimulators Market To Witness Growth Owing To Rising Demand For Cost Effective And Minimally Invasive Surgical...
Global deep brain stimulators market is expected to reach USD 1,592.9 million by 2020, according to a new study by Grand View Research, Inc. Increasing pre
Symptomatic, left-sided deep brain stimulation lead edema 6 h after bilateral subthalamic nucleus lead placement - Surgical...Symptomatic, left-sided deep brain stimulation lead edema 6 h after bilateral subthalamic nucleus lead placement - Surgical...
A Leksell Stereotactic frame was mounted on the patients head. An O-arm® was used to perform a stereotactic volumetric computed tomography (CT) scan of the head. These CT images were then merged with a Stealth navigation system protocol MRI of the brain. A three-dimensional reconstruction of the images was performed to identify the locations of the anterior commissure (AC) and posterior commissure (PC). The coordinates chosen were 12 mm to the left and right of the AC-PC midpoint, 3 mm behind the AC-PC midpoint, and 4 mm below the AC-PC midpoint. The AC-PC distance was measured to be 26.87 mm. After a bifrontal incision, bilateral burr holes overlying the coronal suture were created approximately 4 cm from the midline at each side. Next, a microelectrode drive for the right side was mounted to the Leksell frame. Microelectrode recordings (MERs) were not optimal for the right side, so an O-arm CT scan was performed which showed that the electrodes were lateral and anterior to the desired ...
University Department of Neurology -Outpatient clinic for movement disorderUniversity Department of Neurology -Outpatient clinic for movement disorder
A clinical and scientific focus is the identification and clinical testing of new target points for neuromodulatory therapeutic procedures such as deep brain stimulation. In addition to implementing these new procedures for the treatment of neuropsychiatric disorders, both struct ural imaging by high field-MRI and PET and the acquisition of functional and cognitive neuro-behavioral parameters by Near-Infrared Spect roscopy and Event-related Potentials are used to perform scientific evaluations. In particular, the behavioral effect s of deep brain stimulation as a function of the target and parameters of the stimulation are examined. Investigations of the clinical effect s of deep brain stimulation in atypical Parkinson syndromes (PSP, MSA) and substance dependence are conduct ed in collaboration with colleagues in psychiatry. For example, we have shown in patients with PSP that stimulation of the pedunculopontine nuclei reduces the spontaneous tendency to fall, and that high frequency ...
essential tremoressential tremor
If you or a loved one has Parkinsons disease or essential tremor, you may have heard of deep brain stimulation. But what is it? How does it help? And how is it done here at OHSU? Here are 10 of the most frequently asked questions that can help you learn more. Weve also recently launched a new deep brain stimulation website with details on the procedure and which patients make good candidates. 1. What is deep brain stimulation? Deep … Read More. ...
Medtronic Announces Availability of Its Activa SC Deep Brain Stimulator | MedgadgetMedtronic Announces Availability of Its Activa SC Deep Brain Stimulator | Medgadget
Adding to its Activa line of deep brain stimulation (DBS) devices, Medtronic has announced the US and European launch of its new Activa SC DBS system. The
Does subthalamic nucleus (STN) deep brain stimulation (DBS) increase or decrease impulse control disorders in patients with...Does subthalamic nucleus (STN) deep brain stimulation (DBS) increase or decrease impulse control disorders in patients with...
STN DBS may result in either a favorable or an unfavorable outcome in patients with Parkinson disease and impulse control and related disorders.{ref93} Although there may be resolution or improvement ... more
Research Labs and Institutes | Johns Hopkins MedicineResearch Labs and Institutes | Johns Hopkins Medicine
We investigate the brain networks and neurotransmitters involved in symptoms of movement disorders, such as Parkinsons disease, and the mechanisms by which modulating these networks through electrical stimulation affects these symptoms. We are particularly interested in the mechanisms through which neuromodulation therapies like deep brain stimulation affect non-motor brain functions, such as cognitive function and mood. We use imaging of specific neurotransmitters, such as acetylcholine and dopamine, to understand the changes in brain chemistry associated with the clinical effects of deep brain stimulation and to predict which patients are likely to have changes in non-motor symptoms following DBS. Through collaborations with our neurosurgery colleagues, we explore brain function by making recordings during DBS surgery during motor and non-motor tasks. Dr. Mills collaborates with researchers in the Department of Neurosurgery, the Division of Geriatric and Neuropsychiatry in the Depar...tment ...
APA - Brain Stimulation Therapies for Clinicians Second EditionAPA - Brain Stimulation Therapies for Clinicians Second Edition
A comprehensive survey of the state of current practice, this new edition of Brain Stimulation Therapies for Clinicians provides thoroughly updated information on the growing list of electrical stimulation therapies now in use or under study, including electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), cortical stimulation (CS), and transcranial direct current stimulation (TDCS), as well as new coverage of promising treatments such as low intensity focused ultrasound pulsation (LIFUP) and temporal interference stimulation (TI). After a brief course on the fundamentals of electricity and a refresher on neuroanatomy, the text explores how electricity works within biological systems before progressing to the chapters on individual therapies, which cover the history and evolution of the treatment, the techniques involved, clinical indications, side effects, and an up-to-date review of the evidence base supporting its ...
Essential TremorEssential Tremor
Deep brain stimulation works by implanting fine wires (electrodes) into a specific portion of the brain. This was originally known as thalamic DBS or Vim stim, and initially targeted the thalamus, which is a major relay station deep within the brain. In recent years, many surgeons have been using another area, the posterior subthalamic area (PSA) as the target for deep brain stimulation in essential tremor. Our experience with DBS in the PSA has been extremely encouraging and this is now our preferred target.. ...
Essential TremorEssential Tremor
Deep brain stimulation works by implanting fine wires (electrodes) into a specific portion of the brain. This was originally known as thalamic DBS or Vim stim, and initially targeted the thalamus, which is a major relay station deep within the brain. In recent years, many surgeons have been using another area, the posterior subthalamic area (PSA) as the target for deep brain stimulation in essential tremor. Our experience with DBS in the PSA has been extremely encouraging and this is now our preferred target.. ...
Morphine pump & Deep Brain Stimulation questions - Page 2 - Restless Legs Syndrome (RLS) Discussion BoardMorphine pump & Deep Brain Stimulation questions - Page 2 - Restless Legs Syndrome (RLS) Discussion Board
She also explained that the two of them first need to prepare a paper for publication that summarizes the current facts about the use of DBS to treat RLS. Once that is published, then they can request grant funding for a research project. She had mentioned that she knew that her co-investigator also had potential candidates. What I heard today is that she does not know whether these others are pure RLS patients (like me) or whether they are Parkinsons patients who also have RLS. If it is the latter, then it may increase my chances of being picked since research studies like simple, unambiguous results and not something where others can criticized that the DBS fixed the Parkinsons, so the RLS simply went away. Of course, there is also the argument that DBS is an established treatment for Parkinsons, so the risk to the patient would be lower ...
Neurosurgery Devices Market Worth $13.5 Billion by 2024, Growing at a CAGR of 13% - Haryana DailyNeurosurgery Devices Market Worth $13.5 Billion by 2024, Growing at a CAGR of 13% - Haryana Daily
https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=133872377 Global Market Segmentation:. In the current market scenario, there is a growing demand for neurosurgery devices. The market has been categorized based on the product, application, end user and region.. On the basis of product, the neurosurgery instruments market is segmented into neuromodulation devices and neuroendoscopy devices. The neuromodulation devices segment is projected to register the highest growth during the forecast period. The rising prevalence of neurological disorders and the increasing number of brain surgeries are driving the growth of the neuromodulation devices market.. On the basis of application, the market is segmented into spinal cord stimulation, deep brain stimulation, and neuroendoscopy applications. The deep brain stimulation applications market is further segmented into Parkinsons disease, tremor, depression, and other DBS applications (Alzheimers disease, dystonia, and Tourette syndrome). ...
Boston Scientific buys Intelect Medical for $60MBoston Scientific buys Intelect Medical for $60M
Boston Scientific Corp. has acquired Intelect Medical Inc., a Boston-based company developing technologies for deep brain stimulation for $60 million in cash.. When added to Boston Scientifics existing equity and debt positions in Intelect, the total value of the acquisition stands at around $78 million. Boston Scientific officials said the deal was funded with cash on hand, and that the acquisition would have no impact on its earnings per share for the next three years.. Intelect Medicals deep brain stimulation involves using implantable devices to target therapies to the brain using electrical impulses. Boston Scientific estimates the current worldwide market for DBS at $400 million with projections to grow to more than $1.5 billion by 2020. Boston Scientifics own DBS system, called Vercise DBS, is being evaluated in a clinical trial to treat Parkinsons disease.. In 2008, when Intelect Medical was based in Cleveland, Ohio, Boston Scientific led an investment [1] of at least $11 million in ...
2015 MPCA Annual Conference Exhibitors Showcase - Michigan Primary Care Association2015 MPCA Annual Conference Exhibitors Showcase - Michigan Primary Care Association
Medimmune is the Specialty Division of AstraZeneca, a large bio-pharmaceutical company, and has products in the flu and RSV disease state. The flu product LAIV and palivizumab (Synagis) is the rsv product.. Medtronic. Medtronic deep brain stimulation (DBS) safely and effectively manages some of the most disabling symptoms of essential tremor and Parkinsons disease. Medtronic deep brain stimulation is also approved under a Humanitarian Device Exemption (HDE) for dystonia. Merces Consulting. Merces Consulting Group, Inc., formerly Management Resource Center, Inc., is an independent consulting firm that provides advice and counsel to management of all types of organizations in the development of strategies, programs, and practices that serve to effectively utilize their most important assets- their human resources. Merces has clients nationwide in virtually every industry. The firm began working with its first Health Center client in Michigan in 1993, and established a formal practice dedicated to ...
Temporal Pattern of Brain Stimulation as a New Dimension of Therapeutic Innovation - Department of Biomedical EngineeringTemporal Pattern of Brain Stimulation as a New Dimension of Therapeutic Innovation - Department of Biomedical Engineering
Electrical stimulation for treatment of neurological disorders, diseases, or injuries has relied on controlling the effects of stimulation through selection of stimulation amplitude, pulse duration, and pulse repetition frequency. I introduce a new parameter dimension - the temporal pattern of stimulation - and demonstrate that temporal patterns of stimulation can be used as a probe to understand brain function and therapeutic mechanisms and as a design parameter to increases the efficacy and energy efficiency of neural stimulation therapies. Our finding that the effects of deep brain stimulation (DBS) were dependent on the temporal pattern of stimulation, in addition to the frequency of stimulation, inspired the design of novel temporal patterns of DBS. Patterns were developed that treat the symptoms of PD more effectively than conventional regularly patterned DBS or enable equivalent treatment of symptoms but with a substantial reduction in the required energy. This latter innovation is an ...
Deep Brain Stimulation for Tourette Syndrome » NYU Langone - Annual Report 2013 - Department of NeurosurgeryDeep Brain Stimulation for Tourette Syndrome » NYU Langone - Annual Report 2013 - Department of Neurosurgery
The final result: The tics and other Tourettes symptoms were reduced by 90 percent in the patient, who is today working and attending part-time classes.
Deep brain stimulation - Simple English Wikipedia, the free encyclopediaDeep brain stimulation - Simple English Wikipedia, the free encyclopedia
DBS is helpful for some patients, but other patients have side effects and complications. Patients may experience side effects of apathy, hallucinations, addiction to gambling, hypersexuality, cognitive problems, and depression. However, these may be temporary and related to correct placement and calibration of the stimulator. Some side effects can go away after some time.[23] Because the brain can move a little during surgery, there is the possibility that the electrodes can move out of place. This may cause more complications like personality changes. Electrode movement is easy to find using a CT scan. There may also be complications of surgery, such as bleeding within the brain.[13] In an rare case, a patient with severe Tourettes Syndrome had very severe side effects and complications. The patient suffered from opisthotonus- when the muscles are contracted without the patients control. The patient later died from other infections.[14] ...
Severity of Illness Index | Profiles RNSSeverity of Illness Index | Profiles RNS
Martinez-Ramirez D, Jimenez-Shahed J, Leckman JF, Porta M, Servello D, Meng FG, Kuhn J, Huys D, Baldermann JC, Foltynie T, Hariz MI, Joyce EM, Zrinzo L, Kefalopoulou Z, Silburn P, Coyne T, Mogilner AY, Pourfar MH, Khandhar SM, Auyeung M, Ostrem JL, Visser-Vandewalle V, Welter ML, Mallet L, Karachi C, Houeto JL, Klassen BT, Ackermans L, Kaido T, Temel Y, Gross RE, Walker HC, Lozano AM, Walter BL, Mari Z, Anderson WS, Changizi BK, Moro E, Zauber SE, Schrock LE, Zhang JG, Hu W, Rizer K, Monari EH, Foote KD, Malaty IA, Deeb W, Gunduz A, Okun MS. Efficacy and Safety of Deep Brain Stimulation in Tourette Syndrome: The International Tourette Syndrome Deep Brain Stimulation Public Database and Registry. JAMA Neurol. 2018 03 01; 75(3):353-359 ...
Medial globus pallidusMedial globus pallidus
CamptocormiaCamptocormia
Neuropathic painNeuropathic pain
Jia-Jen LinJia-Jen Lin
Positron emission tomographyPositron emission tomography
CT scanCT scan
Positron emission tomographyPositron emission tomography
Multielectrode arrayMultielectrode array
LobotomyLobotomy
Image-guided surgeryImage-guided surgery
Russell A. BrownRussell A. Brown
RadiosurgeryRadiosurgery
Alim Louis BenabidAlim Louis Benabid
IpilimumabIpilimumab
Krembil Research InstituteKrembil Research Institute
Gottlieb BurckhardtGottlieb Burckhardt
NeuroenhancementNeuroenhancement
S. Matthew LiaoS. Matthew Liao
Wayne GoodmanWayne Goodman
Phantom painPhantom pain
Treatment-resistant depressionTreatment-resistant depression
Cerebellothalamic tractCerebellothalamic tract
Parkinsons diseaseParkinson's disease
Internal globus pallidusInternal globus pallidus
NeuroacanthocytosisNeuroacanthocytosis
Huntington Medical Research InstitutesHuntington Medical Research Institutes
Neural dustNeural dust
HypokinesiaHypokinesia
Mesencephalic locomotor regionMesencephalic locomotor region
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceHealth Care
Deep Brain StimulationSubthalamic NucleusGlobus PallidusParkinson DiseaseHypokinesiaElectrodes, ImplantedEssential TremorStereotaxic TechniquesElectric Stimulation TherapyAntiparkinson AgentsDystoniaDyskinesiasThalamusLevodopaBasal GangliaElectric StimulationTremorMovement DisordersBeta RhythmInternal CapsuleSubthalamusElectrodesDystonic DisordersBrainPedunculopontine Tegmental NucleusTranscranial Magnetic StimulationMuscle RigidityObsessive-Compulsive DisorderModels, NeurologicalBrain MappingParkinsonian DisordersSpeech DisordersSelf StimulationMagnetic Resonance ImagingTourette SyndromeTreatment OutcomeNeural PathwaysNeurosurgical ProceduresPsychosurgeryMicroelectrodesThalamic DiseasesImplantable NeurostimulatorsFunctional LateralitySensation DisordersNeuronsCluster HeadacheDopamine AgentsVagus Nerve StimulationAmplifiers, ElectronicIntralaminar Thalamic NucleiNucleus AccumbensEntopeduncular NucleusBrain ChemistryTime FactorsMotor SkillsDifferential ThresholdElectric CapacitanceElectroencephalographyCarbidopaPallidotomyNeuropsychological TestsNerve NetNeurosurgeryDysarthriaNeurologic ExaminationSignal Processing, Computer-AssistedElectromyographyTicsNeuropsychiatryMotor CortexVentral Thalamic NucleiMyoclonusTorticollisDominance, CerebralAtlases as TopicTherapeutic MisconceptionApomorphineReaction TimeParkinson Disease, SecondaryElectroconvulsive TherapyNeural InhibitionGait Disorders, NeurologicBrain InjuriesAction Potentials1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnalysis of VarianceThermometryMedial Forebrain BundleCerebral CortexEvoked PotentialsDepressive Disorder, Treatment-ResistantBrain NeoplasmsRats, Sprague-DawleyElectrochemical TechniquesSeverity of Illness IndexComputer SimulationMovementBiomedical EnhancementMotor ActivitySubstantia NigraCognitionNeuronal PlasticityStatistics, Nonparametric
Deep Brain StimulationDeep Brain Stimulation
Systems-Level Model of Deep Brain StimulationSystems-Level Model of Deep Brain Stimulation
Deep Brain Stimulation May Help With Driving For People With Parkinsons Disease - RedorbitDeep Brain Stimulation May Help With Driving For People With Parkinson's Disease - Redorbit
Deep Brain Stimulation Surgery for Movement Disorders - Full Text View - ClinicalTrials.govDeep Brain Stimulation Surgery for Movement Disorders - Full Text View - ClinicalTrials.gov
Deep brain stimulation for tremor and dystonia (excluding Parkinsons disease) | Guidance and guidelines | NICEDeep brain stimulation for tremor and dystonia (excluding Parkinson's disease) | Guidance and guidelines | NICE
Deep brain stimulation - Wiki | GoldenDeep brain stimulation - Wiki | Golden
Deep Brain Stimulation May Help in Early Stages of Parkinsons - Consumer Health News | HealthDayDeep Brain Stimulation May Help in Early Stages of Parkinson's - Consumer Health News | HealthDay
Deep Brain Stimulation Think Tank: Updates in Neurotechnology and Neuromodulation Research | Frontiers Research TopicDeep Brain Stimulation Think Tank: Updates in Neurotechnology and Neuromodulation Research | Frontiers Research Topic
Bio-electromagnetic model of deep brain stimulationBio-electromagnetic model of deep brain stimulation
Deep Brain Stimulation Used to Treat Movement Disorders | Tampa General HospitalDeep Brain Stimulation Used to Treat Movement Disorders | Tampa General Hospital
Deep Brain Stimulation | Mind Control Techniques | Mind PowerDeep Brain Stimulation | Mind Control Techniques | Mind Power
Deep Brain Stimulation Devices - Global Market Size, Share & Trends Analysis & Forecast to 2025 - ResearchAndMarkets.com -...Deep Brain Stimulation Devices - Global Market Size, Share & Trends Analysis & Forecast to 2025 - ResearchAndMarkets.com -...
2027 Projections: Deep Brain Stimulation (DBS) Market Report by Type, Application and Regional Outlook - Fractovia.org2027 Projections: Deep Brain Stimulation (DBS) Market Report by Type, Application and Regional Outlook - Fractovia.org
Oweiss Receives $3.9M Grant to Explore Responsive Deep Brain Stimulation - Powering the New EngineerOweiss Receives $3.9M Grant to Explore Responsive Deep Brain Stimulation - Powering the New Engineer
PyDBS: an automated image processing workflow for deep brain stimulation surgery. - InsermPyDBS: an automated image processing workflow for deep brain stimulation surgery. - Inserm
Intraoperative Neurophysiologic Assessment in Deep Brain Stimulation Surgery and its Impact on Lead Placement - Zurich Open...Intraoperative Neurophysiologic Assessment in Deep Brain Stimulation Surgery and its Impact on Lead Placement - Zurich Open...
MicrocircuitDB: Investigation of different targets in deep brain stimulation for Parkinson`s (Pirini et al. 2009)MicrocircuitDB: Investigation of different targets in deep brain stimulation for Parkinson`s (Pirini et al. 2009)
Image-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite study -...Image-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite study -...
Deep brain stimulation: Indications and applications</em>...Deep brain stimulation: Indications and applications</em>...
Deep Brain StimulationDeep Brain Stimulation
Deep brain stimulation: merging brains and machines - Queensland Brain Institute - University of QueenslandDeep brain stimulation: merging brains and machines - Queensland Brain Institute - University of Queensland
deep brain stimulation Archives - Permanente Medicinedeep brain stimulation Archives - Permanente Medicine
Deep Brain Stimulation - la Neurologia ItalianaDeep Brain Stimulation - la Neurologia Italiana
Deep Brain Stimulation: Next Steps | RSRTDeep Brain Stimulation: Next Steps | RSRT
Deep Brain Stimulation Relieves Depression - MEDizzy JournalDeep Brain Stimulation Relieves Depression - MEDizzy Journal
deep brain stimulation | an autodidact meets a dilettante...deep brain stimulation | an autodidact meets a dilettante...
deep brain stimulation | an autodidact meets a dilettante...deep brain stimulation | an autodidact meets a dilettante...
Deep Brain Stimulation Variant Lessens Parkinsons Dyskinesia - StudyDeep Brain Stimulation Variant Lessens Parkinson's Dyskinesia - Study
Psychiatrists Embrace Deep-Brain Stimulation -Psychology Matters AsiaPsychiatrists Embrace Deep-Brain Stimulation -Psychology Matters Asia
Deep Brain Stimulation Improves Paralyzed Rats Gait - Computer EngineeringDeep Brain Stimulation Improves Paralyzed Rat's Gait - Computer Engineering
Do you qualify? | Deep Brain Stimulation | RWJ University HospitalDo you qualify? | Deep Brain Stimulation | RWJ University Hospital
Covid 19 Impact - Deep Brain Stimulation Market Global AnalysisCovid 19 Impact - Deep Brain Stimulation Market Global Analysis
deep brain stimulationdeep brain stimulation
Deep Brain Stimulation (DBS) | Bachmann Strauss Dystonia & Parkinson Foundation, Inc.Deep Brain Stimulation (DBS) | Bachmann Strauss Dystonia & Parkinson Foundation, Inc.
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceHealth Care
Deep Brain StimulationSubthalamic NucleusGlobus PallidusParkinson DiseaseHypokinesiaElectrodes, ImplantedEssential TremorStereotaxic TechniquesElectric Stimulation TherapyAntiparkinson AgentsDystoniaDyskinesiasThalamusLevodopaBasal GangliaElectric StimulationTremorMovement DisordersBeta RhythmInternal CapsuleSubthalamusElectrodesDystonic DisordersBrainPedunculopontine Tegmental NucleusTranscranial Magnetic StimulationMuscle RigidityObsessive-Compulsive DisorderModels, NeurologicalBrain MappingParkinsonian DisordersSpeech DisordersSelf StimulationMagnetic Resonance ImagingTourette SyndromeTreatment OutcomeNeural PathwaysNeurosurgical ProceduresPsychosurgeryMicroelectrodesThalamic DiseasesImplantable NeurostimulatorsFunctional LateralitySensation DisordersNeuronsCluster HeadacheDopamine AgentsVagus Nerve StimulationAmplifiers, ElectronicIntralaminar Thalamic NucleiNucleus AccumbensEntopeduncular NucleusBrain ChemistryTime FactorsMotor SkillsDifferential ThresholdElectric CapacitanceElectroencephalographyCarbidopaPallidotomyNeuropsychological TestsNerve NetNeurosurgeryDysarthriaNeurologic ExaminationSignal Processing, Computer-AssistedElectromyographyTicsNeuropsychiatryMotor CortexVentral Thalamic NucleiMyoclonusTorticollisDominance, CerebralAtlases as TopicTherapeutic MisconceptionApomorphineReaction TimeParkinson Disease, SecondaryElectroconvulsive TherapyNeural InhibitionGait Disorders, NeurologicBrain InjuriesAction Potentials1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnalysis of VarianceThermometryMedial Forebrain BundleCerebral CortexEvoked PotentialsDepressive Disorder, Treatment-ResistantBrain NeoplasmsRats, Sprague-DawleyElectrochemical TechniquesSeverity of Illness IndexComputer SimulationMovementBiomedical EnhancementMotor ActivitySubstantia NigraCognitionNeuronal PlasticityStatistics, Nonparametric
NeurosurgicalElectrodesNeuralAreas of the brainCitation neededDirectParkinson's DiseaseElectrodeDystoniaEssential tremorImpulsesClinicalSurgeryConsider Deep Brain StimuGlobus pallidusResearchersProcedureObsessive compulsiImplantNeurologicalSurgicalNeurosurgeryAmount of stimulationThalamusParkinsonTreatmentGlobal Deep Brain Stimulation DSurgeriesTherapyNeurosurgeonPulsesStimulator could be turned offTreatmentsImplantationStimulateMedtronicSevereInvolves implanting electrodes iSurgicallyNeurologySubthalamic nucleus stimulationRisksTissueHigh-frequencyAbnormalAlzheimer'sExperimentalMovement disordersNeurostimulator2019Pulse generatorContinuousPurpose of deep brain stimuPediatricUndergoTherapiesDeviceAwakeInfectionDepressionTremorHemorrhageSide effects of stimulationNucleus
Neurosurgical2
  • Deep brain stimulation (DBS) is a neurosurgical procedure involving the implantation of a medical device called a neurostimulator (sometimes referred to as a 'brain pacemaker'), which sends electrical impulses, through implanted electrodes, to specific targets in the brain (brain nuclei) for the treatment of movement and neuropsychiatric disorders. (wikipedia.org)
  • DBS directly changes brain activity in a controlled manner, its effects are reversible (unlike those of lesioning techniques), and it is one of only a few neurosurgical methods that allow blinded studies. (wikipedia.org)
Electrodes1
  • The lead is a coiled wire insulated in polyurethane with four platinum-iridium electrodes and is placed in one or two different nuclei of the brain. (wikipedia.org)
Neural1
  • The IPG is a battery-powered neurostimulator encased in a titanium housing, which sends electrical pulses to the brain that interferes with neural activity at the target site. (wikipedia.org)
Areas of the brain1
  • Its direct effect on the physiology of brain cells and neurotransmitters is currently debated, but by sending high frequency electrical impulses into specific areas of the brain it can mitigate symptoms and directly diminish the side-effects induced by Parkinson's medications, allowing a decrease in medications, or making medication regimen more tolerable. (wikipedia.org)
Citation needed1
  • citation needed] There are few sites in the brain that can be targeted to achieve differing results, so each patient must be assessed individually, and a site will be chosen based on their needs. (wikipedia.org)
Direct1
  • During the asleep procedure, intraoperative MRI guidance is used for direct visualization of brain tissue and device. (wikipedia.org)
Parkinson's Disease68
Electrode25
Dystonia14
Essential tremor3
Impulses25
Clinical17
  • de Koning PP, Figee M, van den Munckhof P, Schuurman PR, Denys D (2011) Current status of deep brain stimulation for obsessive-compulsive disorder: a clinical review of different targets. (springer.com)
  • Clinical trials may be available to candidates for deep brain stimulation. (mayoclinic.org)
  • We anticipate that this study will generate a knowledge-base of clinical outcomes to be correlated with stimulation-induced activation of particular brain regions. (utah.edu)
  • We compared the stimulation protocol chosen from the software versus the stimulation protocol that was chosen via clinical practice (independently of the study). (utah.edu)
  • During the second phase we will use the computational models and clinical outcomes from the first phase to build a probabilistic stimulation atlas (PSA) of effective and ineffective stimulation locations 2 . (utah.edu)
  • The object of this study was to identify a preoperative physiological index by using surface electromyography (EMG) signals that would correlate with clinical outcome in dystonic patients following bilateral pallidal stimulation. (thejns.org)
  • Furthermore, a significant correlation was found between the EMG ratio and clinical improvement during the 12-month period following pallidal stimulation. (thejns.org)
  • Deep brain stimulation has been in clinical practice for over a decade and for certain patients can be life changing. (abc.net.au)
  • In a report of the phase II ADvance clinical trial, Johns Hopkins researchers report that people diagnosed under age 65-those with early-onset Alzheimer's disease-didn't benefit from deep brain stimulation. (hopkinsmedicine.org)
  • Scientists say procedure showed improvements but larger clinical experiment needed to confirm benefitsPatients with severeobsessive-compulsivedisorder have shown remarkable improvements after undergoing an experimental procedure in which electrodes are placed inside the brain.The first UK trial of deep brain stimulation for OCD involved six people who were extremely severely affected by the condition. (medworm.com)
  • We will use our model system to decipher the underlying neurophysiological changes responsible therapeutic benefit and define novel stimulation strategies that could improve clinical outcomes. (utah.edu)
  • Incidence and management of air embolisms during awake deep brain stimulation in a large clinical series. (springer.com)
  • Because of the clinical urgency, deep brain stimulation (DBS) treatments for depression have been developed over the past 15 years. (psychcentral.com)
  • For information about clinical trials for deep brain stimulation, including studies that are enrolling patients, please visit the deep brain stimulation results from ClinicalTrials.gov , a service of the National Institutes of Health. (dana.org)
  • Newswise - Vanderbilt University Medical Center is one of approximately 20 centers in a nationwide clinical study investigating the use of deep brain stimulation (DBS) as an intervention for patients with major depression. (newswise.com)
  • BROADENâ„¢ (BROdmann Area 25 DEep brain Neuromodulation) is the first randomized clinical research study to investigate DBS as an intervention for patients diagnosed with unipolar major depressive disorder (excluding bipolar disorder) who have not improved after multiple treatments. (newswise.com)
  • This grant was awarded to Alexander Rotenberg, M.D., Ph.D., Assistant Professor of Neurology, Children's Hospital Boston, and will support a clinical study to evaluate the repetitive transcranial magnetic stimulation (rTMS) H-Coil as a promising non-invasive method of inhibiting the abnormal electrical activity believed to underlie seizures in focal temporal lobe epilepsy (TLE). (disabled-world.com)
Surgery60
Consider Deep Brain Stimu1
  • Who Should Consider Deep Brain Stimulation? (webmd.com)
Globus pallidus4
Researchers22
  • Researchers and doctors have begun using deep brain stimulation (DBS) to treat anorexia nervosa. (thedailybeast.com)
  • Other researchers have demonstrated that this population often experiences painful and severe stimulation-induced dyskinesia ( PloS One . (medscape.com)
  • The algorithm performed well, the researchers noted, with transitions above and below the stimulation threshold appropriately triggered by alterations in the gamma power. (medscape.com)
  • At the University of Amsterdam, researchers bored small holes in his skull and guided two long, thin probes deep into his head. (scientificamerican.com)
  • The researchers realized that in other experiments, stimulation to the same brain region, the nucleus accumbens, had also led to unintended, spontaneous reductions in drinking and smoking. (scientificamerican.com)
  • Canadian researchers have tested the effect of a surgical technique called deep brain stimulation (DBS) on the mood, weight, and overall well-being of 16 patients. (medicalnewstoday.com)
  • The researchers used PET scans to evaluate the brain activity of the patients after undergoing 1 year of DBS. (medicalnewstoday.com)
  • The woman is a patient of Dr. Andres Lozano , a neurosurgeon who is among a growing number of researchers studying the potential of deep brain stimulation to treat Alzheimer's and other forms of dementia. (npr.org)
  • Researchers from the University of California San Francisco and Veterans Affairs Health Care System, San Francisco investigated the safety and efficacy of deep brain stimulation in the treatment of refractory severe tinnitus in a small group of patients. (eurekalert.org)
  • Researchers determined that DBS therapy, targeted to an area of the brain known as Brodmann Area 25, provided noticeable improvement in depression symptoms and increased overall quality of life in patients who typically don't respond to treatment. (psychcentral.com)
  • According to a latest study by researchers, brain stimulation may help depressive patients, when other forms of treatment do not show any result on them. (medindia.net)
  • University of Freiburg) Patients suffering from severe, treatment-resistant depression can benefit not only acutely but also the long-term from deep brain stimulation, as researchers from the Medical Center -- University of Freiburg and their colleagues from the University Hospital Bonn demonstrate in a current study. (medworm.com)
  • Researchers found that in extreme cases of the eating disorder, the technique - known as deep brain stimulation (DBS) - swiftly helped many of those studied reduce symptoms of either anxiety or depression, and improved their quality of life. (foxnews.com)
  • Comparing brain scans from before and after the treatment, the researchers found there were changes in regions linked to anorexia, suggesting the DBS was able to directly affect the related brain circuits. (foxnews.com)
  • A new study by researchers in Canada, who used deep brain stimulation to trigger neuron growth in mice, suggests it can. (time.com)
  • Researchers found that when the brain stimulators were turned on for one hour, the growth of new brain cells in a key region of the hippocampus nearly doubled. (time.com)
  • To be sure that it was the cell growth that was causing improvements in memory, and not some other effect of DBS, the researchers then used a drug to stop the growth of new cells following stimulation. (time.com)
  • In a paper published today by Neuroreport, researchers at Oxford University and Imperial College London report that they have found the exact area of the brain that controls blood pressure and how to make use of it. (innovations-report.com)
  • With the advent of improved brain imaging, researchers are linking certain parts of brain anatomy to conditions ranging from addiction to Alzheimer disease. (alzforum.org)
  • The researchers recorded brain waves of the subjects while they performed the task, once with DBS switched on and once with it off. (medgadget.com)
  • Brain researchers will intermingle with surgeons and academicians in order to form an interdisciplinary expert body, to jump start the Deep Brain Stimulation scene in Bangladesh. (thedailystar.net)
  • Researchers are sliding electrodes into the brains of people with Alzheimer disease, hoping to awaken memories and stave off disease-induced forgetfulness. (alzforum.org)
Procedure18
Obsessive compulsi8
  • The technique is also approved for obsessive-compulsive disorder and is being looked at for a number of other brain disorders, including depression, chronic pain and, as in Lozano's work, dementia. (npr.org)
  • Wyss Center for Bio and Neuroengineering) A new paper published in Nature Reviews Neurology suggests that recent advances in deep brain stimulation (DBS) for Parkinson disease could lead to treatments for conditions such as obsessive-compulsive disorder (OCD), Gilles de la Tourette syndrome and depression. (medworm.com)
  • The debilitating behaviours and all-consuming thoughts, which affect people with severe obsessive compulsive disorder (OCD), could be significantly improved with targeted deep brain stimulation, according to the findings of an MRC-funded study. (medworm.com)
  • In early 2006, an electrical technique, deep brain stimulation, is being proposed for patients with severe depression and obsessive-compulsive disorder. (harvard.edu)
  • Philadelphia, March 7, 2019 -- Deep brain stimulation (DBS) reduces symptoms of severe obsessive-compulsive disorder (OCD) during stimulation of either the ventral capsule (VC) or anteromedial subthalamic nucleus (amSTN), according to a study in Biological Psychiatry . (eurekalert.org)
  • As deep brain stimulation technology improves and as our experience broadens, new disease states are being treated with this technology including psychiatric disorders such as depression and obsessive compulsive disorder. (unc.edu)
  • Though some 55,000 people have received deep-brain stimulation for conditions ranging from Parkinson disease to obsessive-compulsive disorder, there is still plenty of room to improve the process. (alzforum.org)
  • The use of deep brain stimulation (DBS) for obsessive compulsive disorder (OCD) is reviewed, including a brief discussion of historical groundwork in the surgical treatment of psychiatric disorders, and the rationale for the current practice. (nih.gov)
Implant11
Neurological9
  • The authors report the neurological, neurophysiological, and neuropsychological effects of using long-term bilateral pallidal high-frequency deep brain stimulation (DBS) in a case of disabling camptocormia. (thejns.org)
  • While still experimental, deep brain stimulation with implanted electrodes is being tested as a way to ease dementia in patients with Alzheimer's and other neurological conditions. (npr.org)
  • Movement-related symptoms of PD and other neurological conditions are caused by faulty electrical signals in the parts of the brain that control movement. (rochester.edu)
  • Dr. Andre Machado, chairman of the Cleveland Clinic Neurological Institute, is hoping to change that through deep brain stimulation (DBS): By implanting electrodes into the brain that provide small electric pulses, people can regain control over movements lost to stroke. (time.com)
  • Research funded by the National Institute of Neurological Disorders and Stroke (NINDS), a part of the National institutes of Health (NIH), on brain circuitry was critical to the development of DBS. (nih.gov)
  • They soon discovered that stimulation of certain brain nuclei suppresses the symptoms of some neurological disorders. (rutgers.edu)
  • Deep brain stimulation (DBS) is already being used to treat all kinds of mental disorders, including depression and addiction, and some neurological diseases, such as Parkinson's. (medgadget.com)
  • Neurological disorders, or problems in the brain are therefore of paramount importance, as they target the most vital human organ. (thedailystar.net)
  • There are different kinds of neurological disorders like strokes, migraines, brain tumours etc. (thedailystar.net)
Surgical9
Neurosurgery5
  • Led by Chima Oluigbo, M.D. , one of the few pediatric deep brain stimulation experts in North America cross-trained in pediatric and functional neurosurgery, our program has superior expertise in treating patients with all types of movement disorders. (childrensnational.org)
  • Using minimally invasive neurosurgery techniques, we access the brain through a tiny incision in your child's skull. (childrensnational.org)
  • Detailed findings are found in the article, "Phase I trial of caudate deep brain stimulation for treatment-resistant tinnitus," by Steven W. Cheung, M.D., and colleagues, published today in the Journal of Neurosurgery . (eurekalert.org)
  • A successful deep brain stimulation program requires the cooperation of numerous different medical specialties including neurosurgery, neurology, neuropsychology, radiology and anesthesiology. (unc.edu)
  • Our study shows that deep brain stimulation is a safe, effective treatment for young adults with severe Tourette syndrome that cannot be managed with current therapies," said Alon Mogilner, M.D., Ph.D., an associate professor in NYU Langone's departments of neurosurgery and anesthesiology and director of its Center for Neuromodulation, in the statement. (fiercebiotech.com)
Amount of stimulation3
Thalamus4
Parkinson5
Treatment30
  • A DBS treatment might affect other brain functions. (thedailybeast.com)
  • Deep brain stimulation has also been studied and used successfully in the treatment of major depression and chronic pain. (news-medical.net)
  • Deep brain stimulation is also being studied as an experimental treatment for major depression, stroke recovery, addiction and dementia. (mayoclinic.org)
  • Like any other neuropsychiatric intervention, deep brain stimulation can cause several notable side effects and healthcare providers aim to increase the efficacy of treatment while decreasing the risk of these side effects. (news-medical.net)
  • Brain scans also confirmed the benefits of the treatment. (medicalnewstoday.com)
  • Deep brain stimulation is a treatment for uncontrolled, difficult, and sometimes painful movements associated with movement disorders, such as seizures. (childrensnational.org)
  • A recently published multi-center pilot study supports use of deep brain stimulation (DBS) for major depressive disorder for people who have not responded to more traditional modes of treatment. (psychcentral.com)
  • Our results suggest that as we look at deep brain stimulation as a treatment for Alzheimer's disease, we should probably focus on those over 65, which is the bulk of people with Alzheimer's," says Jeannie-Marie Leoutsakos, Ph.D., associate professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. (hopkinsmedicine.org)
  • The mainstays of treatment throughout the disease are drugs such as levodopa that compensate for lost dopamine in the brain. (apdaparkinson.org)
  • At this stage of the disease, deep brain stimulation (DBS) may provide an important treatment option to reduce off time and dyskinesias, and potentially improve quality of life. (apdaparkinson.org)
  • The treatment, called deep brain stimulation, or DBS, has been used to treat a number of other conditions but had never before been tried with anorexia. (thestar.com)
  • Another depression treatment, electroconvulsive therapy (ECT), also uses electrical stimulation - perhaps new brain cell growth could help explain why ECT works. (time.com)
  • The treatment involves the weak electrical stimulation, via implanted electrodes, of a brain region called the subthalamic nucleus. (rdmag.com)
  • We think that deep brain stimulation can be a useful non-drug intervention for treatment of addiction," added Carrie L. Wade, a postdoctoral research associate in the George Laboratory during the study, now at the University of Minnesota. (rdmag.com)
  • However, other research groups are working on less invasive methods of stimulating exact locations in the brain, for example using nanotechnology, and if this becomes available then the treatment would be attractive to a much larger number of people. (innovations-report.com)
  • This finding provides clues as to the roles that those specific brain regions play in OCD, and has potentially important implications for treatment. (eurekalert.org)
  • Deep brain stimulation is an emerging treatment for a small number of individuals with extremely severe OCD whose condition has not responded to multiple courses of currently available treatments such as medication or cognitive behavioral therapy," said Dr. Joyce. (eurekalert.org)
  • Recently, deep brain stimulation (DBS) has become an intervention option for cases of treatment-resistant depression. (psychcentral.com)
  • In the current issue of the journal Biological Psychiatry , Dr. Darin Dougherty and his colleagues report the results of the first large-scale, randomized, sham-controlled trial of deep brain stimulation treatment for treatment-resistant symptoms of depression. (psychcentral.com)
  • But, he cautioned, deep brain stimulation is still in the "investigational" stages as a potential treatment for early Alzheimer's. (drugs.com)
  • Deep brain stimulation: a breakthrough in the treatment of movement disorders," Lege Artis Medicinae , vol. 19, no. 2, pp. 119-126, 2009. (hindawi.com)
  • Deep brain stimulation, or DBS, is one of the many advanced treatment options offered at Loyola Medicine. (loyolamedicine.org)
  • When looking at the tests of people with stimulators when they were turned on or off and off with levodopa, the driving was more accurate with stimulation on than with levodopa, with a total of 13 errors during the test on levodopa, compared to 11 with stimulation and 14 with neither treatment. (redorbit.com)
  • Deep brain stimulation (DBS) will be the treatment option in this study along with behavioral interventions for participants with severe disability due to Traumatic Brain Injury (TBI) 24 months post their injury, the participants will have severe disabilities in behavioral and emotional self-regulation, cognitive impairments and somatic symptoms. (clinicaltrials.gov)
  • The treatment, called Deep Brain Stimulation (DBS), has been proven to be a highly effective therapy that allows for a greater enjoyment of life. (bostonmagazine.com)
  • Recent efforts on patient-specific therapeutic approaches revealed the importance of computational methods in guiding deep brain stimulation (DBS), a neuromodulation treatment initially applied to motor diseases that is fast expanding to include affective disorders, among others. (rutgers.edu)
  • They selected 21 patients who had good responses to treatment, compiled their demographic and treatment information, and used magnetic resonance imaging scans to create 3-D anatomical models with a fine grid to show exact location of relevant brain structures. (scienceblog.com)
  • Deep brain stimulation (DBS) is an emerging interventional therapy for well-screened patients with specific treatment-resistant neuropsychiatric diseases. (jci.org)
  • If this study shows the expected effect in seizure control, the H-Coil could rapidly move to commercialization for TLE treatment because a different version of the H-Coil that targets other deep brain areas is already marketed for treatment of major depression and other neuropsychiatric syndromes. (disabled-world.com)
  • This study shows us a specific mechanism of how DBS improves patients' brain function, which should let us better identify who can benefit and how to optimize their individual treatment. (medgadget.com)
Global Deep Brain Stimulation D5
  • Global Deep Brain Stimulation Devices market report emphasizes on detailed analysis of companies and manufacturers like St Jude Medical, Beijing Pins, SceneRay, Medtronic, Boston Scientific and Others. (openpr.com)
  • The Global Deep Brain Stimulation Devices market report provides detailed segmentation of Global Deep Brain Stimulation Devices Market based on product type, application, end user and regional segmentation. (openpr.com)
  • The Global Deep Brain Stimulation Devices Market analysis report provides detailed value chain for analysis of Global Deep Brain Stimulation Devices Market. (openpr.com)
  • The Global Deep Brain Stimulation Devices Market report explores manufacturer's competitive scenario and provides market share for all major players of this market based on production capacity, sales, revenue, geographical presence and other major factors. (openpr.com)
  • Global Deep Brain Stimulation Devices Market Research Industry Report is prepared with the help of extensive primary and secondary sources, directories, journals, newsletters and with the help of third-party application like Hoovers, Factiva, Bloomberg, Businessweek, etc. (openpr.com)
Surgeries7
Therapy13
Neurosurgeon8
  • In 2013 neurosurgeon Donald Whiting of the West Penn Allegheny Health System and his colleagues reported that by stimulating the lateral hypothalamic area (the "feeding center" of the brain) of three people with intractable obesity, they could reduce their patients' urge to eat. (scientificamerican.com)
  • Emory's Deep Brain Stimulation Program was established in the early 1990's by the newly arrived chair of Neurology, Dr. Mahlon DeLong , together with neurologist Dr. Jerry Vitek and Dr. Roy Bakay, an Emory neurosurgeon. (emoryhealthcare.org)
  • The neurosurgeon performs an operation during which electrodes are placed in specific structures in the brain and then fixed to your skull. (bidmc.org)
  • The Deep Brain Stimulation Program at UC Davis Health is a multidisciplinary program with a diverse team of experts that includes movement disorder neurologists, a neurosurgeon, nurse practitioners, a neurophysiologist, a neuropsychologist, and a psychiatrist. (ucdavis.edu)
  • With DBS, a neurosurgeon will use MRI or CT scanning to pinpoint the exact location in the brain where nerve signals are creating the symptoms. (johnmuirhealth.com)
  • Neurosurgeon Dr. Andres Lozano of the Toronto's University Health Network is conducting a study into the use of deep brain stimulation for those suffering from anorexia nervosa. (thestar.com)
  • There are circuits in the brain that malfunction, that misfire, and it's possible to adjust their activity, to turn them up or down, very much like you would adjust the volume on your television set," says Dr. Andres Lozano, the neurosurgeon who is heading up the study. (thestar.com)
  • As a part of the workshop, world renowned neurosurgeon Prof Tipu Aziz from Oxford University, who is amongst the top neurosurgeon for Lesion and Deep Brain Stimulation, with more than 25 years of experience will interact with neurologists and neurosurgeons of Bangladesh to explain Lesion and DBS. (thedailystar.net)
Pulses12
Stimulator could be turned off2
Treatments4
Implantation3
Stimulate8
Medtronic4
Severe9
Involves implanting electrodes i1
Surgically7
Neurology2
  • This is the first study to compare directly the effects of DBS at two brain sites and has discovered important information about the brain changes in OCD responsible for obsessions and compulsions, depressed mood and cognitive inflexibility and how they might be alleviated," said senior author Eileen Joyce, PhD, The Institute of Neurology, University College London, London, UK. (eurekalert.org)
  • These results are very encouraging for people with Parkinson's and their families that they can take advantage of the benefits of deep brain stimulation without worrying about it increasing the likelihood of developing dementia," said study author Elena Moro, MD, of Grenoble Alpes University in Grenoble, France, and a Fellow of the American Academy of Neurology. (eurekalert.org)
Subthalamic nucleus stimulation2
Risks3
Tissue9
High-frequency3
Abnormal4
Alzheimer's8
  • At the beginning of the small trial, 42 people with mild Alzheimer's had deep brain stimulation devices implanted in the brain in a spot between the hippocampus, which is responsible for learning and memory, and the hypothalamus, which regulates body temperature, hunger and thirst. (hopkinsmedicine.org)
  • Could Deep Brain Stimulation Fend Off Alzheimer's? (time.com)
  • Could generating new cells in brain regions associated with memory stave off the symptoms of Alzheimer's? (time.com)
  • Last year, a small safety study of deep brain stimulation (DBS) in humans found that it slowed rates of cognitive decline and even led to some actual memory improvement in six patients with early stage Alzheimer's. (time.com)
  • THURSDAY, July 28, 2016 -- Deep brain stimulation appears safe for people with early Alzheimer's disease -- and might even slow down memory loss in some, a preliminary study suggests. (drugs.com)
  • While it's far too early to know whether deep brain stimulation helps those with early Alzheimer's, the initial findings suggest the technique is worth further study, said lead researcher Dr. Andres Lozano. (drugs.com)
  • In theory, deep brain stimulation could be helpful because Alzheimer's is marked by a degeneration in brain cells -- with the "circuits" involved in memory, thinking and other mental abilities gradually shutting down, Lozano explained. (drugs.com)
  • More studies are needed to show whether certain Alzheimer's patients stand to benefit from deep brain stimulation, Weintraub said. (drugs.com)
Experimental1
  • Is Deep Brain Stimulation Considered Experimental? (webmd.com)
Movement disorders6
Neurostimulator3
20192
  • 2019. Deep Brain Stimulation Side Effects . (news-medical.net)
  • Transparency Market Research published a new report 'Deep Brain Stimulation Devices Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019' to its report store. (prweb.com)
Pulse generator8
Continuous1
Purpose of deep brain stimu1
Pediatric4
Undergo1
  • Candidates undergo an extensive 2 to 4 hour cognitive evaluation with the neuropsychologist, and also have an MRI brain scan. (ucdavis.edu)
Therapies2
Device8
Awake1
  • Awake the whole time, Adrianna Boot underwent deep brain stimulation to treat her anorexia nervosa more than three years ago. (thestar.com)
Infection2
  • Bhatia R, Dalton A, Richards M, Hopkins C, Aziz T, Nandi D. The incidence of deep brain stimulator hardware infection: the effect of change in antibiotic prophylaxis regimen and review of the literature. (springer.com)
  • There is a small chance of infection, hemorrhage (bleeding) or stroke due to deep brain stimulation. (loyolamedicine.org)
Depression8
  • The first brain area targeted for depression was chosen after years of painstaking neuroimaging research, but recent advancement in DBS has come as much from luck as from planning. (scientificamerican.com)
  • People suffering from sustained depression for over 10 years had reacted positively to stimulation of their brains, when other medication were not working. (medindia.net)
  • This study, conducted at five medical centers across the U.S., found that DBS failed to reduce depression symptoms better than sham stimulation. (psychcentral.com)
  • Deanna took her place on the operating table only a year into the first attempts to stop unrelenting depression by stimulating a precise network of brain cells. (dana.org)
  • But using the technology to treat depression developed from the pioneering work of Helen Mayberg, a neurologist who began her career when brain scanning technology promised to reveal the secrets of the sick brain. (dana.org)
  • Mayberg found that these circuits, particularly a hyperactive network of brain cells in the subgenual cingulate region, also called Brodmann area 25, are abnormally overactive in depression. (dana.org)
  • It made sense that so many brain areas are involved in depression, which encompasses more than just negative mood. (dana.org)
  • In this study, stimulation is being delivered to an area of the brain known as Brodmann Area 25, which is believed to function differently in people with major depression and appears to be overactive when people are profoundly sad and depressed. (newswise.com)
Tremor1
Hemorrhage1
Side effects of stimulation1
  • Furthermore, an independent unique MICC technology (Multiple Independent Current Control) has been incorporated in Vercise DBS system to control the side-effects of stimulation by controlling the current level at each individual contact on the lead. (prweb.com)
Nucleus8
Deep Brain Stimulation (DBS) for the Suppression of Tremor - No Study Results Posted - ClinicalTrials.gov
Deep Brain Stimulation (DBS) for the Suppression of Tremor - No Study Results Posted - ClinicalTrials.gov (clinicaltrials.gov)
Deep Brain Stimulation Abolishes Slowing of Reactions to Unlikely Stimuli | Journal of Neuroscience
Deep Brain Stimulation Abolishes Slowing of Reactions to Unlikely Stimuli | Journal of Neuroscience (jneurosci.org)
What Is Deep Brain Stimulation And When Might It Be Considered To Treat Pain? - ABC News
What Is Deep Brain Stimulation And When Might It Be Considered To Treat Pain? - ABC News (abcnews.go.com)
Camptocormia - Wikipedia
Camptocormia - Wikipedia (en.wikipedia.org)
Dystonia: Symptoms, causes, and types
Dystonia: Symptoms, causes, and types (medicalnewstoday.com)
Deep Brain Stimulation | PBS [Video] : cogsci
Deep Brain Stimulation | PBS [Video] : cogsci (reddit.com)
Canadian Neurological Sciences Federation | Cambridge University Press
Canadian Neurological Sciences Federation | Cambridge University Press (cambridge.org)
American Psychiatric Association (APA) 2016 | Cambridge University Press
American Psychiatric Association (APA) 2016 | Cambridge University Press (cambridge.org)
Deep Brain Stimulation Surgery [image] | EurekAlert! Science News
Deep Brain Stimulation Surgery [image] | EurekAlert! Science News (eurekalert.org)
Deep brain stimulation - Mayo Clinic
Deep brain stimulation - Mayo Clinic (mayoclinic.org)
Essential Tremor | Neurosurgery | Stanford Medicine
Essential Tremor | Neurosurgery | Stanford Medicine (med.stanford.edu)
Cervical Dystonia: Causes, Symptoms, and Treatment
Cervical Dystonia: Causes, Symptoms, and Treatment (healthline.com)
Movement Disorders Unit - Massachusetts General Hospital, Boston, MA
Movement Disorders Unit - Massachusetts General Hospital, Boston, MA (massgeneral.org)
Can Deep Brain Stimulation Help Anorexia?
Can Deep Brain Stimulation Help Anorexia? (thedailybeast.com)
Adaptive Deep-Brain Stimulation Promising for Parkinson's
Adaptive Deep-Brain Stimulation Promising for Parkinson's (medscape.com)
Emily Underwood | Science | AAAS
Emily Underwood | Science | AAAS (sciencemag.org)
Surgery | Book | English | Springer
Surgery | Book | English | Springer (springer.com)
What is Deep Brain Stimulation?
What is Deep Brain Stimulation? (news-medical.net)
Parkinson's 360 | Parkinson's Disease
Parkinson's 360 | Parkinson's Disease (michaeljfox.org)
Deep brain stimulation | News, Videos & Articles
Deep brain stimulation | News, Videos & Articles (globalnews.ca)
Medications & Treatments | Parkinson's Disease
Medications & Treatments | Parkinson's Disease (michaeljfox.org)
Deep brain stimulation for Parkinson's: one woman's journey - Health & Wellbeing
Deep brain stimulation for Parkinson's: one woman's journey - Health & Wellbeing (abc.net.au)
Deep Brain Stimulation for Parkinson Disease: Overview, Mechanism of Action, Advantages and Disadvantages
Deep Brain Stimulation for Parkinson Disease: Overview, Mechanism of Action, Advantages and Disadvantages (emedicine.medscape.com)
Researchers learn to control brain cell that triggers tremor
Researchers learn to control brain cell that triggers tremor (bcm.edu)