Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.Muscular Atrophy: Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.Optic Atrophy: Atrophy of the optic disk which may be congenital or acquired. This condition indicates a deficiency in the number of nerve fibers which arise in the RETINA and converge to form the OPTIC DISK; OPTIC NERVE; OPTIC CHIASM; and optic tracts. GLAUCOMA; ISCHEMIA; inflammation, a chronic elevation of intracranial pressure, toxins, optic nerve compression, and inherited conditions (see OPTIC ATROPHIES, HEREDITARY) are relatively common causes of this condition.Muscular Atrophy, Spinal: A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)Multiple System Atrophy: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)Spinal Muscular Atrophies of Childhood: A group of recessively inherited diseases that feature progressive muscular atrophy and hypotonia. They are classified as type I (Werdnig-Hoffman disease), type II (intermediate form), and type III (Kugelberg-Welander disease). Type I is fatal in infancy, type II has a late infantile onset and is associated with survival into the second or third decade. Type III has its onset in childhood, and is slowly progressive. (J Med Genet 1996 Apr:33(4):281-3)Olivopontocerebellar Atrophies: A group of inherited and sporadic disorders which share progressive ataxia in combination with atrophy of the CEREBELLUM; PONS; and inferior olivary nuclei. Additional clinical features may include MUSCLE RIGIDITY; NYSTAGMUS, PATHOLOGIC; RETINAL DEGENERATION; MUSCLE SPASTICITY; DEMENTIA; URINARY INCONTINENCE; and OPHTHALMOPLEGIA. The familial form has an earlier onset (second decade) and may feature spinal cord atrophy. The sporadic form tends to present in the fifth or sixth decade, and is considered a clinical subtype of MULTIPLE SYSTEM ATROPHY. (From Adams et al., Principles of Neurology, 6th ed, p1085)Gyrate Atrophy: Progressive, autosomal recessive, diffuse atrophy of the choroid, pigment epithelium, and sensory retina that begins in childhood.Geographic Atrophy: A form of MACULAR DEGENERATION also known as dry macular degeneration marked by occurrence of a well-defined progressive lesion or atrophy in the central part of the RETINA called the MACULA LUTEA. It is distinguishable from WET MACULAR DEGENERATION in that the latter involves neovascular exudates.Survival of Motor Neuron 1 Protein: A SMN complex protein that is essential for the function of the SMN protein complex. In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD.Muscular Disorders, Atrophic: Disorders characterized by an abnormal reduction in muscle volume due to a decrease in the size or number of muscle fibers. Atrophy may result from diseases intrinsic to muscle tissue (e.g., MUSCULAR DYSTROPHY) or secondary to PERIPHERAL NERVOUS SYSTEM DISEASES that impair innervation to muscle tissue (e.g., MUSCULAR ATROPHY, SPINAL).Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Optic Atrophy, Autosomal Dominant: Dominant optic atrophy is a hereditary optic neuropathy causing decreased visual acuity, color vision deficits, a centrocecal scotoma, and optic nerve pallor (Hum. Genet. 1998; 102: 79-86). Mutations leading to this condition have been mapped to the OPA1 gene at chromosome 3q28-q29. OPA1 codes for a dynamin-related GTPase that localizes to mitochondria.SMN Complex Proteins: A complex of proteins that assemble the SNRNP CORE PROTEINS into a core structure that surrounds a highly conserved RNA sequence found in SMALL NUCLEAR RNA. They are found localized in the GEMINI OF COILED BODIES and in the CYTOPLASM. The SMN complex is named after the Survival of Motor Neuron Complex Protein 1, which is a critical component of the complex.Survival of Motor Neuron 2 Protein: A SMN complex protein that is closely-related to SURVIVAL OF MOTOR NEURON 1 PROTEIN. In humans, the protein is encoded by an often duplicated gene found near the inversion centromere of a large inverted region of CHROMOSOME 5.Hindlimb Suspension: Technique for limiting use, activity, or movement by immobilizing or restraining animal by suspending from hindlimbs or tails. This immobilization is used to simulate some effects of reduced gravity and study weightlessness physiology.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Bulbo-Spinal Atrophy, X-Linked: An X-linked recessive form of spinal muscular atrophy. It is due to a mutation of the gene encoding the ANDROGEN RECEPTOR.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Gastritis, Atrophic: GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.SKP Cullin F-Box Protein Ligases: A subset of ubiquitin protein ligases that are formed by the association of a SKP DOMAIN PROTEIN, a CULLIN DOMAIN PROTEIN and a F-BOX DOMAIN PROTEIN.Optic Atrophies, Hereditary: Hereditary conditions that feature progressive visual loss in association with optic atrophy. Relatively common forms include autosomal dominant optic atrophy (OPTIC ATROPHY, AUTOSOMAL DOMINANT) and Leber hereditary optic atrophy (OPTIC ATROPHY, HEREDITARY, LEBER).Cerebellar Ataxia: Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)Uveal Diseases: Diseases of the uvea.Organ Size: The measurement of an organ in volume, mass, or heaviness.Supranuclear Palsy, Progressive: A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)Muscle Proteins: The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.Facial Hemiatrophy: A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.Ornithine-Oxo-Acid Transaminase: A pyridoxal phosphate enzyme that catalyzes the formation of glutamate gamma-semialdehyde and an L-amino acid from L-ornithine and a 2-keto-acid. EC 2.6.1.13.Shy-Drager Syndrome: A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)Muscle Denervation: The resection or removal of the innervation of a muscle or muscle tissue.Muscle Fibers, Skeletal: Large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of SKELETAL MUSCLE. They consist of MYOFIBRILS enclosed within and attached to the SARCOLEMMA. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation.Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Spinocerebellar Degenerations: A heterogenous group of degenerative syndromes marked by progressive cerebellar dysfunction either in isolation or combined with other neurologic manifestations. Sporadic and inherited subtypes occur. Inheritance patterns include autosomal dominant, autosomal recessive, and X-linked.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Temporal Lobe: Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.Neuronal Apoptosis-Inhibitory Protein: An inhibitor of apoptosis protein that was initially identified during analysis of CHROMOSOME DELETIONS associated with SPINAL MUSCULAR ATROPHY. Naip contains a nucleotide binding oligomerization domain and a carboxy-terminal LEUCINE rich repeat.Pepsinogen A: This is one of 2 related pepsinogen systems in humans and is also known as pepsinogen. (The other is PEPSINOGEN C.) This includes isozymogens Pg1-Pg5 (pepsinogens 1-5, group I or products of PGA1-PGA5 genes). This is the main pepsinogen found in urine.Myoclonic Epilepsies, Progressive: A heterogeneous group of primarily familial disorders characterized by myoclonic seizures, tonic-clonic seizures, ataxia, progressive intellectual deterioration, and neuronal degeneration. These include LAFORA DISEASE; MERRF SYNDROME; NEURONAL CEROID-LIPOFUSCINOSIS; sialidosis (see MUCOLIPIDOSES), and UNVERRICHT-LUNDBORG SYNDROME.Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.Immobilization: The restriction of the MOVEMENT of whole or part of the body by physical means (RESTRAINT, PHYSICAL) or chemically by ANALGESIA, or the use of TRANQUILIZING AGENTS or NEUROMUSCULAR NONDEPOLARIZING AGENTS. It includes experimental protocols used to evaluate the physiologic effects of immobility.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.Macular Degeneration: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.Motor Neurons: Neurons which activate MUSCLE CELLS.Fundus Oculi: The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)Myostatin: A growth differentiation factor that is a potent inhibitor of SKELETAL MUSCLE growth. It may play a role in the regulation of MYOGENESIS and in muscle maintenance during adulthood.Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Cerebellar Diseases: Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.Hippocampus: A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.Nerve Tissue ProteinsPedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Cyclic AMP Response Element-Binding Protein: A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.Anterior Horn Cells: MOTOR NEURONS in the anterior (ventral) horn of the SPINAL CORD which project to SKELETAL MUSCLES.Fluorescein Angiography: Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.Celiac Disease: A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.Pepsinogen C: This is one of the 2 related pepsinogen systems in humans. It is found in prostate and seminal fluid whereas PEPSINOGEN A is not.Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.Frontotemporal Dementia: The most common clinical form of FRONTOTEMPORAL LOBAR DEGENERATION, this dementia presents with personality and behavioral changes often associated with disinhibition, apathy, and lack of insight.Cerebral Cortex: The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.Choroid: The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Muscle Weakness: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)Cerebellum: The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.Mild Cognitive Impairment: A prodromal phase of cognitive decline that may precede the emergence of ALZHEIMER DISEASE and other dementias. It may include impairment of cognition, such as impairments in language, visuospatial awareness, ATTENTION and MEMORY.Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Cerebral Ventricles: Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).RNA-Binding Proteins: Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Gastritis: Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
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Multiple-system-Muscular atrophyProgressive atrophyMusclesSecretionDiagnosisProgressionContralateralSymptomsVaginalWeaknessMuscular AtrophyShrinkageNeuronal AtrophyHypertrophyTesticular atrophyInterest in sexBrain parenchymalLesionOccursCognitiveTremorsTissueThymusInducesPathologicalProteinCommonlyProteinsRatsReceptorsLesionsNerveMenopauseShrinkIncreasesNeuronsLossClosely
Multiple-system-1
- Shy-Drager Syndrome, also known as Multiple System Atrophy , is a rare degenerative disorder which causes progressive damage to the central and autonomic nervous system s. (everything2.com)
Muscular atrophy1
- Proximal spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by deficiency of the ubiquitous Survival of Motor Neuron (SMN) protein. (ntnu.edu.tw)
Progressive atrophy1
- Parry-Romberg Syndrome (PRS) is an uncommon disorder characterized by a slowly and acquired progressive atrophy involving skin, soft tissue, cartilage, and bony structures. (clinmedjournals.org)
Muscles1
- Clinically, it is characterized by progressive hemifacial atrophy, skin involvement, adipose tissue, muscles and sometimes adjacent bone tissue, where usually involving dermatomes of one or more branches of the fifth cranial nerve (V) [ 1 ], with a higher frequency of reaching the left side [ 2 ]. (clinmedjournals.org)
Secretion1
- Treatment of cells with monensin to disrupt Golgi-mediated granule secretion decreased SMN expression in neurites and caused growth cone defects similar to those seen in SMN knockdown cells. (ntnu.edu.tw)
Diagnosis1
- Early diagnosis and prompt o ptic nerve atrophy stem cell treatment in Delhi India can help the patients with compressive and toxic neuropathies. (stemcellcareindia.com)
Progression2
- The progression was satisfactory, with the end of the progression of atrophy, within a follow-up of 18 months. (clinmedjournals.org)
- The main objective is to stop the progression of atrophy. (clinmedjournals.org)
Contralateral3
- We report an extremely unusual case with PRS associated with contralateral lower extremity atrophy. (clinmedjournals.org)
- We report an extremely unusual case with PRS associated with contralateral lower extremity atrophy, complicated by dorso-lumbar scoliosis and inequality of the 2 lower limbs. (clinmedjournals.org)
- Our patient had a right hemifacial lesion (V3 territory) with an extension of the atrophy towards the contralateral lower limb, which was rarely previously described in the literature [ 1 , 5 , 6 ]. (clinmedjournals.org)
Symptoms13
- Investigators at Nationwide Children's Hospital may have discovered a biological explanation for why low levels of oxygen advance spinal muscular atrophy (SMA) symptoms and why breathing treatments help SMA patients live longer. (nationwidechildrens.org)
- changes in your vision Decreased urine output These symptoms indicate worsening of the condition and an increased risk to you and your baby, including death . (symptoma.com)
- This article examines some helpful natural remedies, lifestyle changes, and medical treatments that can reduce symptoms and enhance quality of life for women with vaginal atrophy . (medicalnewstoday.com)
- There are several lifestyle changes that could help women relieve the symptoms of vaginal atrophy. (medicalnewstoday.com)
- Limited research on 87 women suggests that probiotics might help relieve the symptoms of vaginal atrophy. (medicalnewstoday.com)
- In carpal tunnel syndrome , swelling compresses the nerves in the forearm, causing a variety of symptoms including pain, aches, tingling, weakness, and numbness in the wrists, fingers, or forearms, as well as decreased grip strength. (healthcentral.com)
- Multiple system atrophy- parkinsonian type (MSA-P) is a rare condition that causes symptoms similar to Parkinson disease . (medlineplus.gov)
- For many women, vaginal atrophy not only makes intercourse painful but also leads to distressing urinary symptoms. (mayoclinic.org)
- Because the condition causes both vaginal and urinary symptoms, doctors use the term "genitourinary syndrome of menopause (GSM)" to describe vaginal atrophy and its accompanying symptoms. (mayoclinic.org)
- Symptoms associated with elemental mercury poisoning can include tremors , muscle atrophy, twitching, insomnia , and emotional changes. (emedicinehealth.com)
- Symptoms of vaginal atrophy can include pain and bleeding during sex. (healthcentral.com)
- The symptoms of posterior cortical atrophy can vary from one person to the next and can change as the condition progresses. (alz.org)
- Other symptoms can include difficulty performing mathematical calculations or spelling, and many people with posterior cortical atrophy experience anxiety, possibly because they know something is wrong. (alz.org)
Vaginal16
- The decreased production of estrogen and progesterone can affect the thin layer of moisture that coats the vaginal walls. (healthline.com)
- Vaginal atrophy refers to inflammation, dryness, and thinning of the vaginal walls. (medicalnewstoday.com)
- While there are many treatments for vaginal atrophy, some people prefer a natural approach. (medicalnewstoday.com)
- Smoking decreases estrogen levels and increases the risk of developing vaginal atrophy, as well as other conditions, such as osteoporosis . (medicalnewstoday.com)
- At present, scientific research provides little evidence to support any claims that dietary changes can help women with vaginal atrophy. (medicalnewstoday.com)
- People with vaginal atrophy should discuss any herbal supplements or dietary changes with their doctor before making any long-term lifestyle changes to manage a condition. (medicalnewstoday.com)
- Some women with vaginal atrophy might also develop urinary problems, and probiotics might also be helpful in managing vaginal dryness. (medicalnewstoday.com)
- As well as natural remedies and lifestyle changes, there are several medications for treating vaginal atrophy. (medicalnewstoday.com)
- Vaginal atrophy can occur at any age, although one main cause is reduced estrogen production in the ovaries during menopause . (medicalnewstoday.com)
- Women with premenopause alongside other medical conditions that reduce the levels of estrogen in the body can also develop vaginal atrophy. (medicalnewstoday.com)
- Vaginal atrophy (atrophic vaginitis) is thinning, drying and inflammation of the vaginal walls that may occur when your body has less estrogen. (mayoclinic.org)
- Vaginal atrophy occurs most often after menopause. (mayoclinic.org)
- Vaginal atrophy, also known as atrophic vaginitis, vulvovaginal atrophy and urogenital atrophy, is a condition that causes the vagina and tissue near the vagina to get dry, thin and inflamed. (wellmark.com)
- Treatment options for vaginal atrophy includes fractional CO 2 laser therapy which delivers controlled energy to the vaginal tissue leaving the surrounding tissue intact, this allows faster healing as the mucosa of the vaginal wall is rejuvenated. (wellmark.com)
- Some of these changes aren't physically noticeable, such as vaginal atrophy . (healthcentral.com)
- While pain during sex is more common after menopause because of vaginal atrophy, it doesn't mean that you need to stop having sex and enjoying intimacy in your relationship. (healthcentral.com)
Weakness5
- Patients with spinal muscular atrophy types III and IV usually present with an insidious onset of weakness, often following a brief period of illness, such as with influenza. (medscape.com)
- Proximal muscle weakness is seen in spinal muscular atrophy, with the pelvic girdle being more affected than the shoulder girdle. (medscape.com)
- Acta1 (H40Y) heterozygotes display clinical and pathological features of patients with nemaline myopathy, including severe, early onset limb and eyelid muscle weakness, decreased mobility, presence of cytoplasmic and nuclear nemaline rods, and increased mortality. (jax.org)
- Specifically, heterozygous mice of both sexes display severe muscle weakness (beginning ~15 days of age), and decreased ambulation, reduced body weight (loss of body and facial muscle mass/emaciated appearance), ruffled hair, kyphosis (hunchbacked appearance), watery eyes and ptosis (drooping eyelids) all by 21 days of age. (jax.org)
- When a muscle atrophies, this leads to muscle weakness, since the ability to exert force is related to mass. (wikipedia.org)
Muscular Atrophy10
- The exact etiology of spinal muscular atrophy (SMA) is unknown. (medscape.com)
- Consensus statement for standard of care in spinal muscular atrophy. (medscape.com)
- Function changes in spinal muscular atrophy II and III. (medscape.com)
- A collaborative study on the natural history of childhood and juvenile onset proximal spinal muscular atrophy (type II and III SMA): 569 patients. (medscape.com)
- Respiratory capacity course in patients with infantile spinal muscular atrophy. (medscape.com)
- Muscular atrophy decreases qualities of life as the sufferer becomes unable to perform certain tasks or worsen the risks of accidents while performing those (like walking). (wikipedia.org)
- Muscular atrophy affects a high number of the elderly. (wikipedia.org)
- Spinal muscular atrophy with pontocerebellar hypoplasia (SMA-PCH) is an infantile SMA variant with additional manifestations, particularly severe microcephaly. (jneurosci.org)
- Spinal muscular atrophy (SMA), the leading genetic cause of infant mortality, is characterized by the deterioration of alpha motor neurons in the brainstem and spinal cord. (nature.com)
- Spinal muscular atrophy (SMA) is a genetic neuromuscular disease that results in the degeneration of alpha motor neurons of the spinal cord and brainstem [ 1 ]. (nature.com)
Shrinkage1
- Most commonly affecting younger men (ages 15-35), varicocele can cause pain, shrinkage of the testicles (testicular atrophy), and infertility. (bostonmagazine.com)
Neuronal Atrophy1
- Both proteins decreased mHTT-induced striatal neuronal atrophy. (plos.org)
Hypertrophy1
- To optimize exercise interventions in diabetics, the chronology of inflammatory mediators in muscle and the signaling involved in muscle hypertrophy/atrophy must be understood. (frontiersin.org)
Testicular atrophy6
- During development of a NIOSH criteria document on glycidyl ethers, a pattern of research findings emerged which indicates that some of the glycidyl ethers may be capable of producing testicular atrophy and hemopoietic abnormalities in various species of laboratory animals. (cdc.gov)
- Additionally, after the issuance of the June 1978 NIOSH criteria document, a 1957 study was released to NIOSH reporting testicular atrophy in laboratory rats exposed to n-butyl glycidyl ether. (cdc.gov)
- NIOSH is not aware of any studies investigating the possibility of occurrence of testicular atrophy or hemopoietic abnormalities occurring in humans exposed to glycidyl ethers. (cdc.gov)
- Therefore, NIOSH requests that any information regarding testicular atrophy or hemopoietic abnormalities observed in workers exposed to glycidyl ethers be reported to the NIOSH Division of Surveillance, Hazard Evaluations, and Field Studies, Industry-Wide Studies Branch, Medical Section, Telephone: (513) 684-3593. (cdc.gov)
- Particular attention should be given to appropriate medical surveillance in order to detect testicular atrophy or hemopoietic abnormalities in exposed workers. (cdc.gov)
- Testicular atrophy was noted in all 25,000 ppm males. (epa.gov)
Interest in sex1
- This can lead to a decreased interest in sex. (healthcentral.com)
Brain parenchymal1
- Corpus callosum index (CCI) is an easy to use MRI marker for estimating brain atrophy in patients with MS. Demonstrated correlation of CCI and atrophy has been measured with brain parenchymal fraction. (clinicaltrials.gov)
Lesion2
- C, reduced staining seen in a simple atrophy lesion from the same patient as that in ( A ). Magnification, ×100. (aacrjournals.org)
- D, high-power view of another simple atrophy lesion showing reduced but variable staining. (aacrjournals.org)
Occurs5
- (wellness.com)
- Muscle atrophy occurs by a change in the normal balance between protein synthesis and protein degradation. (wikipedia.org)
- What occurs with atrophy? (studystack.com)
- Dendritic atrophy or malformation of SPNs occurs in several basal ganglia disorders and it is likely to impact on these neurons' synaptic connectivity and intrinsic excitability 9 . (nature.com)
- Most cases of Alzheimer's disease occur in people age 65 or older, whereas the onset of posterior cortical atrophy commonly occurs between ages 50 and 65. (alz.org)
Cognitive4
- What causes the negative cognitive effects of diabetes, especially brain atrophy and decreased processing speed? (childrenwithdiabetes.com)
- I get very concerned when I read about the negative cognitive effects of diabetes, especially brain atrophy and decreased processing speed. (childrenwithdiabetes.com)
- decreased cognitive functions. (emedicinehealth.com)
- an extensive literature suggests that hippocampal atrophy of the magnitude found in these disorders can give rise to such cognitive deficits. (nih.gov)
Tremors2
- is there a way to decrease twitching and tremors caused by bfs? (healthtap.com)
- Multiple system atrophy (MSA), also known as Shy-Drager syndrome, is a rare neurodegenerative disorder characterized by tremors, slow movement, muscle rigidity, and postural instability (collectively known as parkinsonism) due to dysfunction of the autonomic nervous system, and ataxia. (wikipedia.org)
Tissue2
- The outside genital tissue decreases. (drugs.com)
- This won't give you back your estrogen but it will help keep the tissue healthy and promote natural moisture and therefore decrease the pain. (healthcentral.com)
Thymus1
- Thymus atrophy during early human development (childhood) is an example of physiologic atrophy. (wikipedia.org)
Induces1
- Angiotensin II (AngII) induces muscle atrophy. (clinsci.org)
Pathological1
- What causes pathological atrophy? (studystack.com)
Protein4
- Our in-vitro experiments identified thioredoxin 1 and thioredoxin-related transmembrane protein 3 as proteins that decrease soluble mHTT levels in cultured cells. (plos.org)
- During atrophy, there is a down-regulation of protein synthesis pathways, and an activation of protein degradation. (wikipedia.org)
- The particular protein degradation pathway which seems to be responsible for much of the muscle loss seen in a muscle undergoing atrophy is the ATP-dependent ubiquitin/proteasome pathway. (wikipedia.org)
- The hypertrophic effects of Akt are modulated partly by stimulating protein synthesis pathways downstream of GSK3β and mTOR ( Schiaffino and Mammucari, 2011 ), whereas the muscle-specific ubiquitin ligases MAFbx and MuRF1 are important for activating muscle atrophy. (frontiersin.org)
Commonly1
- Many people affected by multiple system atrophy experience dysfunction of the autonomic nervous system, which commonly manifests as orthostatic hypotension, impotence, loss of sweating, dry mouth and urinary retention and incontinence. (wikipedia.org)
Proteins2
- Glucocorticoids, a class of medications used to treat allergic and other inflammatory conditions can induce muscle atrophy by increasing break-down of muscle proteins. (wikipedia.org)
- During muscle atrophy, MAFbx and MuRF1 bind to and mediate the ubiquitination of myofibrillar proteins for subsequent degradation. (frontiersin.org)
Rats2
- Acute infection with an avirulent strain of Toxoplasma gondii causes decreasing and atrophy of nitrergic myenteric neurons of rats. (plu.mx)
- Furthermore, a study applying the Golgi-Cox silver impregnation technique to rats with 6-OHDA lesions failed to detect dendritic atrophy in unidentified SPNs 15 . (nature.com)
Receptors1
- but with aging the receptors decrease in number, said Joe Signorile, of UM's Human Performance Laboratory. (baltimoresun.com)
Lesions1
- Although PD has a complex pathology, striatal DA denervation by means of 6-OHDA lesions was sufficient to induce dendritic atrophy in both SPN populations and a short course of L-DOPA treatment did not reverse this effect 3 . (nature.com)
Nerve2
- Resistance to such movement may be decreased, resulting in observation of a larger range of motion than normal, if the nerve leading to the muscle is damaged. (wellness.com)
- Neurogenic atrophy, which has a similar effect, is muscle atrophy resulting from damage to the nerve which stimulates the muscle, causing a shriveling around otherwise healthy limbs. (wikipedia.org)
Menopause1
- Genitourinary syndrome of menopause is caused by a decrease in estrogen production. (mayoclinic.org)
Increases1
- Increases LDL, decreases HDL. (brainscape.com)
Neurons1
- The remaining nitrergic neurons suffered atrophy in the areas of the cell body and nucleus, which resulted in a decrease in cytoplasm. (plu.mx)
Loss2
- No loss of strength or atrophy. (healthtap.com)
- loss, decreased workload. (studystack.com)
Closely1
- Atrophy is closely related to the inflammatory signaling pathways ( Bonaldo and Sandri, 2013 ). (frontiersin.org)
