The hormone-responsive glandular layer of ENDOMETRIUM that sloughs off at each menstrual flow (decidua menstrualis) or at the termination of pregnancy. During pregnancy, the thickest part of the decidua forms the maternal portion of the PLACENTA, thus named decidua placentalis. The thin portion of the decidua covering the rest of the embryo is the decidua capsularis.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
The thin layers of tissue that surround the developing embryo. There are four extra-embryonic membranes commonly found in VERTEBRATES, such as REPTILES; BIRDS; and MAMMALS. They are the YOLK SAC, the ALLANTOIS, the AMNION, and the CHORION. These membranes provide protection and means to transport nutrients and wastes.
The beginning third of a human PREGNANCY, from the first day of the last normal menstrual period (MENSTRUATION) through the completion of 14 weeks (98 days) of gestation.
The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
The threadlike, vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA).
The outermost extra-embryonic membrane surrounding the developing embryo. In REPTILES and BIRDS, it adheres to the shell and allows exchange of gases between the egg and its environment. In MAMMALS, the chorion evolves into the fetal contribution of the PLACENTA.
The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.
Endometrial implantation of EMBRYO, MAMMALIAN at the BLASTOCYST stage.
The innermost membranous sac that surrounds and protects the developing embryo which is bathed in the AMNIOTIC FLUID. Amnion cells are secretory EPITHELIAL CELLS and contribute to the amniotic fluid.
The most common (>96%) type of ectopic pregnancy in which the extrauterine EMBRYO IMPLANTATION occurs in the FALLOPIAN TUBE, usually in the ampullary region where FERTILIZATION takes place.
Collection of granular epithelial cells in the uterine muscle beneath the placenta that develop during pregnancy in certain species of animals.
The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).
Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)
A hypothalamic hormone that is synthesized as a precursor protein which is cleaved into two peptides. In addition to stimulating PROLACTIN release the peptides bind to specific G-PROTEIN-COUPLED RECEPTORS found at locations within the BRAIN.
The last third of a human PREGNANCY, from the beginning of the 29th through the 42nd completed week (197 to 294 days) of gestation.
An acyclic state that resembles PREGNANCY in that there is no ovarian cycle, ESTROUS CYCLE, or MENSTRUAL CYCLE. Unlike pregnancy, there is no EMBRYO IMPLANTATION. Pseudopregnancy can be experimentally induced to form DECIDUOMA in the UTERUS.
The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.
The disintegration and assimilation of the dead FETUS in the UTERUS at any stage after the completion of organogenesis which, in humans, is after the 9th week of GESTATION. It does not include embryo resorption (see EMBRYO LOSS).
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
The beginning of true OBSTETRIC LABOR which is characterized by the cyclic uterine contractions of increasing frequency, duration, and strength causing CERVICAL DILATATION to begin (LABOR STAGE, FIRST ).
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The 140 kDa isoform of NCAM (neural cell adhesion molecule) containing a transmembrane domain and short cytoplasmic tail. It is expressed by all lymphocytes mediating non-MHC restricted cytotoxicity and is present on some neural tissues and tumors.
The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.
A low affinity interleukin-11 receptor subunit that combines with the CYTOKINE RECEPTOR GP130 to form a high affinity receptor for INTERLEUKIN-11. Multiple isoforms of this protein exist due to ALTERNATIVE SPLICING of its MRNA.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A vascular endothelial growth factor whose expression is found largely restricted to the GONADS; ADRENAL CORTEX; and PLACENTA. It has similar biological activity to VASCULAR ENDOTHELIAL GROWTH FACTOR-A.
The retention in the UTERUS of a dead FETUS two months or more after its DEATH.
The smooth muscle coat of the uterus, which forms the main mass of the organ.
Intentional removal of a fetus from the uterus by any of a number of techniques. (POPLINE, 1978)
A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Three or more consecutive spontaneous abortions.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
The circulation of BLOOD, of both the mother and the FETUS, through the PLACENTA.
Class I human histocompatibility (HLA) surface antigens encoded by alleles on locus B of the HLA complex. The HLA-G antigens are considered non-classical class I antigens due to their distinct tissue distribution which differs from HLA-A; HLA-B; and HLA-C antigens. Note that several isoforms of HLA-G antigens result from alternative splicing of messenger RNAs produced from the HLA-G*01 allele.
Chemical substances that interrupt pregnancy after implantation.
A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta.
A plant family of the order Pinales, class Pinopsida, division Coniferophyta, known for the various conifers.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
A plant genus of the family CAPPARACEAE that contains mabinlin, a sweet protein.
The oily substance secreted by SEBACEOUS GLANDS. It is composed of KERATIN, fat, and cellular debris.
A type of climate characterized by insufficient moisture to support appreciable plant life. It is a climate of extreme aridity, usually of extreme heat, and of negligible rainfall. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A plant genus of the family CHENOPODIACEAE. The extract may be called lochein. Tumbleweed may occasionally refer to AMARANTHUS.
A water-soluble medicinal preparation applied to the skin.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.

Marker genes of decidualization: activation of the decidual prolactin gene. (1/1114)

Decidualization of human endometrial stromal (ES) cells in vitro is induced by cAMP analogues and ligands that elevate cellular cAMP levels in a manner resembling the gonadotrophins, prostaglandin E2 and relaxin (RLX). This differentiation process is marked by the onset of decidual prolactin (PRL) production in the late luteal phase of the cycle. Using transfection assays and a primary ES cell culture system, we have demonstrated that decidual PRL gene transcription is driven by an alternative upstream promoter (dPRL), approximately 6 kb upstream of the pituitary transcription start site. In primary cell cultures, RLX not only acutely but also permanently elevated cellular cAMP levels and induced PRL secretion after 6 days. Northern and Western blot analyses revealed all regulatory subunit isoforms (RIalpha, RIbeta, RIIalpha, RIIbeta) and catalytic subunits Calpha and Cbeta of protein kinase A (PKA) in ES cells. Transcript levels of PKA subunit isoforms are not altered during decidualization, but in decidualized ES cells exposed to elevated cellular cAMP levels by stimulation with RLX for >6 days, RIalpha protein levels were significantly reduced, whereas levels of all other forms remained unchanged. Reducing the availability of R subunits changed the R:C subunit ratio in favour of C and increased kinase activity. In transient transfections of undifferentiated ES cells, the dPRL promoter was activated by 8-Br-cAMP and by C subunit (Cbeta) of PKA. This induction, and the differentiation-dependent activity of the dPRL promoter in transfected decidualized cells, was effectively abolished by the co-expression of protein kinase inhibitor (PKI). A fragment of 332 bp of 5'-flanking region of the dPRL transcription start site was sufficient to mediate full inducibility by cAMP. cAMP activation of the dPRL promoter in ES cells was biphasic as an initial weak induction within 12 hours was followed by a subsequent, much more intense induction after 12 hours. The secondary induction was not seen with a control construct driven by a consensus cAMP response element (CRE) linked to a minimal promoter. The early response of the dPRL promoter depended upon a non-palindromic CRE at position -12 and mutation of this sequence led to omission of the early, but not of the delayed, induction. The major activation of the dPRL promoter depended upon a different region between position -332 and -270 since its deletion significantly reduced inducibility by cAMP. Its action was probably indirect as its kinetics differed from classic CRE-mediated responses, and it was specific to ES cells.  (+info)

Ryk is expressed in a differentiation-specific manner in epithelial tissues and is strongly induced in decidualizing uterine stroma. (2/1114)

Ryk is a ubiquitously expressed tyrosine kinase-like receptor of unknown activity and associations. We examined ryk expression in adult mouse epithelial tissues and during embryonic development at the histological level. Ryk RNA is present at greatly increased levels in cells at particular stages of epithelial differentiation: the basal layer of skin and tongue epithelia, the intervillous layer and some crypt bases of the intestine and the lower matrix region of the hair follicle. Although ryk RNA is expressed at similar levels in a variety of tissues from embryonic day 10.5 to 18.5, specific induction of ryk RNA can be seen by in situ hybridization in the basal layer of skin and hair follicle at day 15.5-16.5, and protein staining localizes to the hair follicle by immunohistochemistry. At day 4.5 and 6.5, little if any ryk is present in the blastocyst, but it is transiently induced at a high level in mature decidual cells of the uterine stroma. We review a number of independent isolations of ryk, including fruit fly and nematode members of the ryk family. Because ryk is induced in epithelial cells seeking a final place in a differentiated tissue, or during remodeling of the endometrium, and a homologous gene, derailed, is known to regulate muscle and nerve target seeking in Drosophila, ryk may also be involved in cellular recognition of appropriate context.  (+info)

Cytosolic phospholipase A2 in rat decidual cells: evidence for its role in decidualization. (3/1114)

We investigated the existence and possible role of cytosolic phospholipase A2 (cPLA2) in rat decidualized uteri. PLA2 activity in the cytosol of a decidualized uterine horn, induced by intraluminal oil infusion, was significantly higher than that in contralateral intact horn. The activity was almost completely depressed by cPLA2 inhibitors including arachidonyl trifluoromethyl ketone (ATK). The immunoreactive signals for cPLA2 were intense in decidua and glandular epithelial cells. In vivo administration of ATK (0.1-100 microg) caused a dose-dependent inhibition of decidualization. These results show the presence of cPLA2 and its probable implication in decidualization in rat uterus.  (+info)

Prostaglandin endoperoxide H synthase mRNA expression in the human amnion and decidua during pregnancy and in the amnion at preterm labour. (4/1114)

We have examined the expression of prostaglandin endoperoxide H synthase (PGHS) isoenzymes in the amnion and the decidua during gestation, and the abundance of PGHS mRNA in the amnion at idiopathic preterm labour. PGHS-1 and -2 mRNA abundance in the amnion, determined with ribonuclease protection assays, was significantly (P< 0.05) higher at term than earlier during pregnancy. In contrast, neither PGHS-1 and -2 mRNA values, nor PGHS-specific activity, measured with a cell-free assay, was different in the decidua at term as compared to earlier gestational ages. In individual term patients, PGHS-2 mRNA values in the amnion were positively correlated with PGHS-2 mRNA values in the chorion laeve. PGHS-1 and -2 mRNA abundance was higher (P < 0.05) in the amnion after idiopathic preterm labour than in the absence of labour at the same gestational age (28-35 weeks). Thus, PGHS-1 and -2 are induced in the amnion at term. Furthermore, amniotic PGHS-2 changes in co-ordination with PGHS-2 concentrations in the chorion laeve. PGHS is not induced in the decidua at term. Increased amniotic PGHS expression may contribute to the enhanced intrauterine prostaglandin synthesis before term labour. Both PGHS isoenzymes may participate in the increase of PGHS activity in the amnion at preterm birth.  (+info)

Gestational regulation of granulocyte-colony stimulating factor receptor expression in the human placenta. (5/1114)

A number of cytokines and their receptors are abundantly expressed at the materno-fetal interface and are thought to have a function in the regulation of placentation. Granulocyte-colony stimulating factor (G-CSF) is expressed by stromal cells in both placental tissue and maternal decidua throughout placentation. In this study, we examined the expression of placental G-CSF receptor (G-CSFR) mRNA and protein throughout gestation by ribonuclease protection assays, Western blotting, and immunohistochemistry. The major placental form of G-CSFR mRNA, corresponding to a membrane-bound form of the protein, was present in first-trimester placental tissues; levels decreased in second- and were highest in third-trimester placental tissues. Two placental G-CSFR molecules, 120 kDa and 150 kDa, were detected in first- and third-, but not second-, trimester tissues. The level of the 150-kDa G-CSFR was greater in the third- than in first-trimester samples. These differences were irrespective of whether or not the patients had received prostaglandin E1 analogues, prostaglandin E1 analogues and oxytocin, oxytocin alone, or mifepristone before labor. We demonstrated by immunohistochemistry that interstitial cytotrophoblast in first- and second-trimester decidual tissue and cytotrophoblast in term fetal membranes express G-CSFR. These data demonstrate that the expression of specific forms of placental G-CSFR is strictly cell type- and developmental stage-specific, and they suggest that G-CSFR may be important in decidual invasion of cytotrophoblast and in trophoblast function during placentation.  (+info)

Spatiotemporal expression of cyclooxygenase 1 and cyclooxygenase 2 during delayed implantation and the periimplantation period in the Western spotted skunk. (6/1114)

Embryonic development in the western spotted skunk is arrested after blastocyst formation for about 200 days. This developmental arrest is believed to be due to insufficiency of uterine conditions to support continuous development. Implantation and decidualization are defective in cyclooxygenase 2 (Cox2)-, but not Cox1-, deficient mice. We therefore used Northern and in situ hybridization to investigate changes in uterine expression of Cox1 and Cox2 genes during various stages of pregnancy in the spotted skunk. Cox1 was constitutively expressed at all stages of pregnancy examined, but it did exhibit localized up-regulation in the trophoblast and necks of uterine glands at early implantation sites. Cox2 expression was highly regulated with little or no expression during delayed implantation. Cox2 expression was first detected in the uterus and trophoblast prior to blastocyst attachment and remained detectable for 5-6 days after blastocyst attachment. Cox2 expression was also localized in the luminal and glandular epithelia of uterine segments located between implantation chambers. Changes in Cox expression were not correlated with the abrupt increase in uterine weight that occurs simultaneously with renewed embryonic development but was correlated with an influx of serum proteins into the uterus observed in a previous study.  (+info)

Localization of ubiquitin and ubiquitin cross-reactive protein in human and baboon endometrium and decidua during the menstrual cycle and early pregnancy. (7/1114)

We have examined the distribution of ubiquitin and the related ubiquitin cross-reactive protein (UCRP) in paraffin-embedded sections of human and baboon endometrium and decidua by immunoperoxidase or immunofluorescence cytochemistry with antibodies raised against ubiquitin, UCRP, CD45, and insulin-like growth factor-binding protein-1. Anti-ubiquitin immunoreactivity was present in the nonpregnant endometrium, particularly in the glandular epithelial cells, and up-regulated in endometrial stromal cells as they decidualized at the beginning of pregnancy. Anti-UCRP immunoreactivity was absent from nonpregnant tissue but accumulated to high levels in decidual cells during pregnancy. Western blotting indicated that immunoreactivity was primarily due to the presence of ubiquitin and UCRP conjugated to other proteins, and that although levels of ubiquitin-protein conjugates do not change substantially during pregnancy, decidualization is accompanied by the appearance of conjugates of UCRP. Baboon uterine tissues demonstrated a similar distribution of the two proteins, which indicates that the baboon may be a useful model for study of the role of the ubiquitin system and UCRP in the establishment of pregnancy in humans.  (+info)

Tissue plasminogen activator and its receptor in the human amnion, chorion, and decidua at preterm and term. (8/1114)

The plasminogen activator system consists of two proteins: tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which act upon their specific receptors to generate plasmin from plasminogen located on the cell surface. Plasmin then acts directly and indirectly to degrade the components of the extracellular matrix (ECM). This process is likely to be important in the normal turnover of the ECM of fetal membranes and in its premature weakening in preterm premature rupture of the fetal membranes. Quantitative Northern analysis and in situ hybridization have shown that the decidua expresses mRNA for tPA. However, the immunolocalized tPA protein was most strongly associated with the amnion and chorion, as was its receptor annexin II, suggesting that the amnion and chorion are the targets for decidual tPA. At term, decidual tPA expression was unaffected by labor, and the tPA receptor was elevated both before and after labor. At preterm, the converse was found: decidual tPA expression was significantly (p < 0. 05) up-regulated by labor, but the tPA receptor was not. The results suggest that the generation of plasmin at term would be controlled by an increased concentration of the tPA receptor in the amnion and chorion, whereas at preterm a pathological increase in plasmin would be generated by an overexpression of tPA, initiated by labor.  (+info)

TY - JOUR. T1 - Endometrial stromal decidualization responds reversibly to hormone stimulation and withdrawal. AU - Yu, Jie. AU - Berga, Sarah L.. AU - Johnston-MacAnanny, Erika B.. AU - Sidell, Neil. AU - Bagchi, Indrani C.. AU - Bagchi, Milan K.. AU - Taylor, Robert N.. PY - 2016/6. Y1 - 2016/6. N2 - Human endometrial stromal decidualization is required for embryo receptivity, angiogenesis, and placentation. Previous studies from our laboratories established that connexin (Cx)-43 critically regulates endometrial stromal cell (ESC) differentiation, whereas gap junction blockade prevents it. The current study evaluated the plasticity of ESC morphology and Cx43 expression, as well as other biochemical markers of cell differentiation, in response to decidualizing hormones. Primary human ESC cultureswere exposedto 10 nM estradiol, 100 nM progesterone, and 0.5 mM cAMPfor up to 14 days, followed by hormone withdrawal for 14 days, mimicking a biphasic ovulatory cycle. Reversible differentiation was ...
Methods have been developed for isolating human tissue macrophages from first trimester or term pregnancy decidua. After a two stage enzymic digestion, viable cells were separated from cellular debris by velocity sedimentation at unit gravity or by Percoll centrifugation. Cell populations were analysed by flow cytometry after labelling with monoclonal antibodies. In term decidua, 47% of the cells were of bone marrow origin, comprising 18% macrophages, 3% large granular lymphocytes and 8% T cells. The remaining cells, the proportion of which varied between individuals, were CD16-positive granulocytes. Macrophages were isolated flow cytometrically from both first trimester and term decidual cell dispersions after labelling with an antibody to MHC class II. Yields of up to 4 X 10(6) macrophages, greater than 95% pure, were routinely obtained.
Uterine spiral artery remodeling is required for successful human pregnancy; impaired remodeling is associated with pregnancy complications, including late miscarriage, preeclampsia, and fetal growth restriction. The molecular triggers of remodeling are not known, but it is now clear that there are trophoblast-independent and trophoblast-dependent stages. Uterine natural killer (uNK) cells are abundant in decidualized endometrium in early pregnancy; they surround spiral arteries and secrete a range of angiogenic growth factors. We hypothesized that uNK cells mediate the initial stages of spiral artery remodeling. uNK cells and extravillous trophoblast (EVT) cells were isolated from early pregnancy decidua and placenta. Chorionic plate arteries from full-term placentas and spiral arteries from nonpregnant myometrium were cultured with angiogenic growth factors or conditioned medium (CM) from uNK cells or EVT or uNK cell/EVT cocultures. In both vessel models, uNK cell CM induced disruption of ...
Supplementary Materialsijms-20-05994-s001. immune responses [15,16,17]. In addition, is usually up-regulated in the endometrial cells of pregnant women compared to non-pregnant women [18]. Up-regulated had been found in both the nucleus and cytoplasm in the decidual stromal cells of human first-trimester endometrium [18]. In an in vitro decidualization model, was up-regulated and only the short isoform translocated to the nucleus of endometrial stromal cells [18]. Given these facts, we were thinking about exploring the hyperlink between your macrophage and gene polarization in individual deciduas. Investigations of decidual macrophages polarity and stability may help to clarify their jobs in pregnancies and could pave the best way to therapies of pathological pregnancies. 2. Outcomes 2.1. NLRP7 Portrayed in Decidual Macrophages from the First-Trimester Being pregnant Our previous research discovered that may donate to the decidualization of endometrial stromal cells [18]. We continued to explore ...
Supplementary Materialsijms-20-05994-s001. immune responses [15,16,17]. In addition, is usually up-regulated in the endometrial cells of pregnant women compared to non-pregnant women [18]. Up-regulated had been found in both the nucleus and cytoplasm in the decidual stromal cells of human first-trimester endometrium [18]. In an in vitro decidualization model, was up-regulated and only the short isoform translocated to the nucleus of endometrial stromal cells [18]. Given these facts, we were thinking about exploring the hyperlink between your macrophage and gene polarization in individual deciduas. Investigations of decidual macrophages polarity and stability may help to clarify their jobs in pregnancies and could pave the best way to therapies of pathological pregnancies. 2. Outcomes 2.1. NLRP7 Portrayed in Decidual Macrophages from the First-Trimester Being pregnant Our previous research discovered that may donate to the decidualization of endometrial stromal cells [18]. We continued to explore ...
इस अध्ययन के एक सत्यापित और अलगाव और मानव एंडोमेट्रियल stromal कोशिकाओं की संस्कृति के लिए प्रक्रिया को इन विट्रो...
A successful pregnancy requires that the maternal immune system adapts to tolerate the semi-allogeneic fetal-placental unit. This adaptation mainly occurs locally, i.e. at the fetal-maternal interface, where fetal-derived tissues come into close contact with maternal cells in the uterine endometrium (called decidua during pregnancy). Macrophages and regulatory T (Treg) cells are maternal immune cells that are enriched in the decidua and they likely play a central role in promoting fetal tolerance. However, the precise function of decidual macrophages and the factors regulating both macrophages and Treg cells in humans are unknown. The aim of this thesis was to characterize the phenotype and function of decidual macrophages from first trimester human pregnancy and to identify factors responsible for inducing tolerogenic properties in both decidual macrophages and Treg cells. CD14+ decidual macrophages showed characteristics of immune suppressive or homeostatic macrophages (expression of CD163, ...
Supplementary Materials http://advances. DSC) of decidua sample P6D_10x. Fig. S9. Differentially expressed genes between VCT and EVT predicated on Wilcoxon rank sum test. Table S1. Test details of decidua and villi data. Data document S1. Average appearance profiles of most cell types of placenta. Data document S2. Appearance of receptors and ligands. Data file S3. Differential gene expression analysis by Wilcoxon rank sum test. Abstract The placenta and decidua interact dynamically to enable embryonic and fetal development. Here, we report single-cell RNA sequencing of 14,341 and 6754 cells from first-trimester human placental villous and decidual tissues, respectively. Bioinformatic analysis identified main cell types, many known plus some subtypes unidentified in placental villi and decidual framework previously. Complete evaluation uncovered proliferating subpopulations Further, enrichment of cell typeCspecific transcription elements, and putative intercellular conversation in the ...
TY - JOUR. T1 - Expression of the interleukin-2 receptor α (CD25) is selectively decreased on decidual CD4 + and CD8 + T lymphocytes in normal pregnancies. AU - Chao, Kunag Han. AU - Wu, Ming Yih. AU - Yang, Jehn Hsiahn. AU - Chen, Shee Uan. AU - Yang, Yu Shih. AU - Ho, Hong Nerng. PY - 2002/7/22. Y1 - 2002/7/22. N2 - In a previous study, we demonstrated that the proportion of activated T cells (CD69 +CD3 + and HLA-DR +CD3 +) is higher in the endometrium and decidua after the luteal phase and throughout early pregnancy compared with in the peripheral blood. However, there was no difference in the proportion of CD25 +CD3 + lymphocytes between the endometrium and peripheral blood. In this study, we further verify that the levels of CD25 on CD4 + and CD8 + T lymphocytes are not increased in normal pregnancy, although the levels of CD69 and HLA-DR are markedly increased. We also elucidate that the amounts of all three activation molecules on local T lymphocytes are down-regulated in pregnancy ...
Objective: One of the most serious complications after hematopoietic stem cell transplantation is acute graftversus- host disease (GVHD), which develops when donor- derived T-cells recognize and become activated by alloreactive recipient tissue. We were the first to use bone marrow-derived mesenchymal stem cells (BM-MSCs) to reverse severe steroid-refractory acute GVHD and hemorrhagic cystitis. The fetus is protected against the mothers immune system by the fetal membrane. We wanted to explore if stromal cells from the placenta could be used for GVHD and tissue damage in a similar way as MSCs. Materials and Methods: We collected stromal cells from various parts of the placenta. To characterize these cells, we used fluorescence activated cell sorter (FACS). For functional analysis, mixed lymphocyte culture (MLC) and mitogen stimulation of human and mice cells were used. For studies of GVHD, we used B6 mice as donors and Balb/C mice as recipients of hematopoietic stem cell transplants. Patients ...
BackgroundAlthough uterine macrophages are thought to play an important regulatory role at the maternal-fetal interface, their global gene expression profile is not known.Methodology/Principal FindingsUsing micro-array comprising approximately 14,000 genes, the gene expression pattern of human first trimester decidual CD14+ monocytes/macrophages was characterized and compared with the expression profile of the corresponding cells in blood. Some of the key findings were confirmed by real time PCR or by secreted protein. A unique gene expression pattern intrinsic of first trimester decidual CD14+ cells was demonstrated. A large number of regulated genes were functionally related to immunomodulation and tissue remodelling, corroborating polarization patterns of differentiated macrophages mainly of the alternatively activated M2 phenotype. These include known M2 markers such as CCL-18, CD209, insulin-like growth factor (IGF)-1, mannose receptor c type (MRC)-1 and fibronectin-1. Further, the selective up
In cycling rodents, the circulating E and P are produced and secreted by the concerted actions of ovarian granulosa and theca cells (10). The adrenal glands in rodents are incapable of synthesizing significant levels of these steroid hormones (11). In pregnant mice, the corpora lutea develop fully by d 3 of pregnancy and start to produce P, the level of which increases and remains elevated until mid-gestation (12). In contrast, the level of serum E, which is high on d 1 of pregnancy because of the preovulatory hormonal surge, decreases and reaches approximately 15 pg/mL on d 2 and 3. The serum E level increases transiently to approximately 22 pg/mL on d 4 of pregnancy and plays a critical role in embryo attachment. When the embryo attaches to the uterus, the ovarian E synthesis decreases. During the decidualization phase, which lasts from d 5 through 8 of gestation, the circulating level of E remains low at approximately 15 pg/mL (12). When the ovaries were removed after embryo attachment, ...
Introduction: At the maternal fetal interface, the decidua may play a role in labor, a process which involves the prostaglandin (PG) pathway (important clinical target for labor management). However, the PG pathway is highly complex with three rate limiting steps, and its complexity remains to be addressed in the decidua. We hypothesize the decidua exhibits 1) a distinct expression profile of PG genes with labor, and 2) differential expression in preterm labor (PTL) compared to term labor ...
Uterine decidualization, a process that occurs in response to embryo implantation, is critical for embryonic survival and thus is a key event for successful pregnancy. Here we show that the sphingolipid metabolic pathway is highly activated in the deciduum during pregnancy and disturbance of the pathway by disruption of sphingosine kinase (Sphk) genes causes defective decidualization with severely compromised uterine blood vessels, leading to early pregnancy loss. Sphk-deficient female mice (Sphk1-/-Sphk2+/-) exhibited both an enormous accumulation of dihydrosphingosine and sphingosine and a reduction in phosphatidylethanolamine levels in pregnant uteri. These mice also revealed increased cell death in decidual cells, decreased cell proliferation in undifferentiated stromal cells, and massive breakage of decidual blood vessels, leading to uterine hemorrhage and early embryonic lethality. Thus, sphingolipid metabolism regulates proper uterine decidualization and blood vessel stability. Our ...
Abstract: In early human pregnancy, uterine decidual NK cells (dNK) are abundant and considered as cytokine producers but poorly cytotoxic despite their cytolytic granule content, suggesting a negative control of this latter effector function. To investigate the basis of this control, we examined the relative contribution to the cytotoxic function of different activating receptors expressed by dNK. Using a multicolor flow cytometry analysis, we found that freshly isolated dNK exhibit a unique repertoire of activating and inhibitory receptors, identical among all the donors tested. We then demonstrated that in fresh dNK, mAb-specific engagement of NKp46-, and to a lesser extent NKG2C-, but not NKp30-activating receptors induced intracellular calcium mobilization, perforin polarization, granule exocytosis and efficient target cell lysis. NKp46-mediated cytotoxicity is coactivated by CD2 but dramatically blocked by NKG2A coengagement, indicating that the dNK cytotoxic potential could be tightly ...
Fingerprint Dive into the research topics of IL-18 is present at the maternal-fetal interface and enhances cytotoxic activity of decidual lymphocytes. Together they form a unique fingerprint. ...
Uncovering the causes of pregnancy complications such as preterm labor requires greater insight into how the uterus remains in a noncontractile state until term and then surmounts this state to enter labor. Here, we show that dynamic generation and erasure of the repressive histone modification tri-methyl histone H3 lysine 27 (H3K27me3) in decidual stromal cells dictate both elements of pregnancy success in mice. In early gestation, H3K27me3-induced transcriptional silencing of select gene targets ensured uterine quiescence by preventing the decidua from expressing parturition-inducing hormone receptors, manifesting type 1 immunity, and most unexpectedly, generating myofibroblasts and associated wound-healing responses. In late gestation, genome-wide H3K27 demethylation allowed for target gene upregulation, decidual activation, and labor entry. Pharmacological inhibition of H3K27 demethylation in late gestation not only prevented term parturition, but also inhibited delivery while maintaining ...
Even after intensive study, many of the maternal immunological adaptations to pregnancy are not well elucidated. It is known that pregnancy is associated with an increase in the CD4+ T cells that secrete Th2-type cytokines-for example interleukins (Fragiadakis, 2016). Th1-type cytokine production-for example, interferon gamma and interleukin 2-appears to be somewhat suppressed, leading to a Th2 bias in pregnancy. This bias affects the ability to rapidly eliminate certain intracellular pathogens during pregnancy, although the clinical implications of this suppression are unknown (Kourtis, 2014; Svensson-Arvelund, 2014). Importantly, the Th2 humoral immune response remains intact. It also appears that human leukocyte antigen (HLA)-C expressed by extravillous trophoblasts elicits responses from decidual natural killer (dNK) and decidual CD8+ T cells (Crespo, 2017). ...
Immunological adaptations in pregnancy allow maternal tolerance of the semi-allogeneic fetus but also increase maternal susceptibility to infection. At implantation, the endometrial stroma, glands, arteries and immune cells undergo anatomical and functional transformation to create the decidua, the specialized secretory endometrium of pregnancy. The maternal decidua and the invading fetal trophoblast constitute a dynamic junction that facilitates a complex immunological dialogue between the two. The decidual and peripheral immune systems together assume a pivotal role in regulating the critical balance between tolerance and defense against infection. Throughout pregnancy, this equilibrium is repeatedly subjected to microbial challenge. Acute viral infection in pregnancy is associated with a wide spectrum of adverse consequences for both mother and fetus. Vertical transmission from mother to fetus can cause developmental anomalies, growth restriction, preterm birth and stillbirth, while the ...
Nancy P, Tagliani E, Tay CS, Asp P, Levy DE, Erlebacher A. Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science. 2012 Jun 8;336(6086):1317-21. PubMed PMID: 22679098 ...
DNK (citozin-5-)-metiltransferaza (EC 2.1.1.37, EcoRI metilaza, DNK 5-citozinska metilaza, DNK citozinska C5 metilaza, DNK citozinska metilaza, DNK metilaza, DNK metiltransferaza, DNK transmetilaza, DNK-citozinska 5-metilaza, DNK-citozinska metiltransferaza, HpaII metilaza, HpaII metilaza, M.BsuRIa, M.BsuRIb, Tip II DNK metilaza, citozinska 5-metiltransferaza, citozinska DNK metilaza, citozinska DNK metiltransferaza, citozin-specifična DNK metiltransferaza, dezoksiribonukleinska metilaza, dezoksiribonukleinska metiltransferaza, dezoksiribonukleinska (citozin-5-)-metiltransferaza, dezoksiribonukleinska kiselina (citozin-5-)-metiltransferaza, dezoksiribonukleinska kiselina metilaza, dezoksiribonukleinska kiselina metiltransferaza, metilaza modifikacije dezoksiribonukleinske kiseline, dezoksiribonukleinska metilaza, metilfosfotriester-DNK metiltransferaza, modifikaciona metilaza, restrikciono-modifikacioni sistem, site-specifična DNK-metiltransferaza (citozin-specifična), DNK-(citozin ...
Bernard, O; Scheid, M P.; Ripoche, M; and Bennett, D, Immunological studies of mouse decidual cells. I. Membrane markers of decidual cells in the days after implantation. (1978). Subject Strain Bibliography 1978. 2751 ...
Transcriptomes of about 70,000 single cells from first-trimester deciduas and placentas reveal subsets of perivascular, stromal and natural killer cells in the decidua, according to new research by CTR published on Nature
Mast cells (MCs) are largely known as primary responders in allergic reactions and important cells of the innate immune system. However, recent studies reveal that MCs in fact also play a critical role in the Treg-dependent allograft tolerance by secreting interleukin-9 (IL)-9. In the light of this breaking role for MCs we embarked on a series of studies aiming to analyze whether MCs may be implicated in tolerance towards the semiallogenic fetus growing within the maternal uterus. We confirmed the presence of MCs at the fetal-maternal interface preferentially in maternal decidua (Fig. 1). Their peak is observed around implantation. Fetal rescue by means of antigen-specific Treg was associated with an augmented number of MCs as well as with enhanced expression of MC-related molecules (Tph-1, Mcpt-1 and Mcpt-5) at the fetal-maternal interface and in other organs. Treg treatment was further associated with an increase in the levels of well-known MC growth factors mSCF and IL-3, while IL-9 remained ...
Most of the evidence supporting the sterile womb paradigm was generated with traditional microscopy or culture-based techniques, which are today considered deficient for assessing a microbiome. Researchers have therefore turned to molecular approaches, such as next-generation sequencing, and recent studies have produced evidence (summarized in Table 1) that challenges the sterile womb paradigm. Reports employing these techniques propose that bacteria are not only present within the fetal environment in healthy full-term pregnancies [8, 9, 37, 38], but that they also constitute a placental microbiome that jump-starts the colonization of the fetus [8-10] as part of its normal developmental process [39]. Additionally, it has been suggested that the uterus contains its own microbiome that can contribute to fetal colonization, as the placenta develops from both fetal trophoblasts and maternal decidua (the inner lining of the uterus) [40, 41].. After the early studies on the meconium discussed above, ...
indeciduate definition: indeciduous; Having no decidua; nondeciduate.; Indeciduous.; Having no decidua; nondeciduate.; perhaps not deciduate, as a placenta: applied and to those placental animals when…
nondeciduate definition: described as the lack of a decidua; indeciduate.; described as the absence of a decidua; indeciduate.; just like indeciduate.
|i|Background:|/i| Following implantation, endometrial stroma is transformed into decidual tissue via a complex remodeling process. In parallel with that process, a significant increase in
Previously, we have shown by in situ hybridization that the expression of IGFBP-4, a potential IGF-I inhibitor, correlates to the expression pattern described
Produkty výrobcu ALK-Abelló A/S (DNK) registrované v SR. Informácie o výdaji, doplatkoch, spôsobe užívania. Rozsiahle možnosti vyhľadávania. Denne aktualizované.
Prvobitna analiza DNK kromosoma Y, koja se, kao i mitohondrijska DNK, nasljeđuje od samo jednog roditelja, bila je dosljedna modelu nedavnog afričkog pretka. Međutim, mitohondrijski i podaci sa Y kromosoma nisu se mogli objasniti istom ekspanzijom modernog čovjeka iz Afrike; ekspanzija Y kromosoma uključivala bi genetsko miješanje koje bi zadržalo regionalno lokalne mitohondrijske linije. Uz to, podaci s Y kromosoma ukazali su na kasnije širenje natrag u Afriku iz Azije, pokazavši da genski tok među regijama nije bio jednosmjeran.[81] Rana analiza 15 nekodirajućih dijelova kromosoma X otkrila je dodatne nepodudarnosti s hipotezom nedavnog afričkog pretka. Ta analiza pronašla je višemodalnu distribuciju vremena koalescencije do najmlađeg zajedničkog pretka za te segmente DNK, u suprotnosti s očekivanjima za nedavnu afričku zamjenu; bilo je više vremena koalescencije prije gotovo 2 milijuna godina nego što se očekivalo, što ukazuje na to da se jedna drevna populacija odvojila ...
Nukleosóm je pri evkariotih enota v organizaciji kromatina, ki obsega približno 146 baznih parov DNK, ki je 1,67-krat tesno ovita okrog histonskega oktamera, torej osmih histonskih molekul (po dve kopiji histonov H2A, H2B, H3, H4).[1]. Nukleosome povezuje povezovalna DNK dolžine do 80 baznih parov vezana na zunanji histon H1. Nukleosomi omogočajo strnjenost celotne dednine v jedru, ki meri približno 10 μm. Več nukleosomov se povezuje v kromosom. Nukleosomi so nosilci epigenetskih informacij v obliki kovalentnih modifikacij pripadajočih jedrnih histonov. Niso statične, temveč dinamične strukture. Vezavo transkripcijskih faktorjev na posamezna mesta na DNK lahko facilitirajo ali zavirajo.. ...
Doktor bioloških znanosti, ki tekoče bere DNK, deloma pa tudi literaturo. Navdušuje ga pregibanje telesa in možgana v vse smeri, deloma tudi navznoter. Uživa v širjenju navdihujočih idej, deloma tudi v obliki čivkov. ...
R.T.Gergova, M.P.Slavova, V.I.Boev, M.S.Mourdjeva, L.K.Yotova, R.T.Georgieva-Nikolova Comparative investigation of the feasibility of bacterial biofilms formation on the surface of the hybrid material UREASIL. Bulgarian Chemical Communications, 47, 2, 706-713, 2015.. ISSN: 0324-1130IF: 0.349. Elena Stoyanova, M. Mourdjeva, S. Kyurjchiev. Early selection of human fibroblast-derived induced pluripotent stem cells. Biotechnology & Biotechnological Equipment, 29, 5, 942-948, 2015.. ISSN: 1310-2818IF:0.3. Kyurkchiev D, E.Naydenov, K.Tumangelova-Yuzeir, E.Ivanova-Todorova, K.Belemezova, I.Bochev, K.Minkin, M.Mourdjeva, T.Velikova, S.Nachev, S.Kyurkchiev Cells Isolated from Human Glioblastoma Multiforme Express Progesterone-Induced Blocking Factor (PIBF). Cellular and Molecular Neurobiology, 34, 1, 479-489, 2014. ISSN: 0272-4340 IF: 2.506. K.Belemezova, I.Bochev, M.Mourdjeva, A.Shterev, S.Kyurkchiev Effect of GNRH analogues ganirelix and triptorelin on human endometrial stromal cell decidualization in ...
Granularity is a characteristic of both dNK and CD56dim pNK cells, both of which are also called large granular lymphocytes (65), whereas CD56bright pNK cells are known to be less granular (15). Granzyme B and perforin (components of cytotoxic granules) were expressed at similar levels in dNK and CD56dim pNK cells, whereas granzyme A was 3- and 10-fold overexpressed in dNK cells versus the CD56dim and CD56bright pNK cells, respectively (Fig. 3 C). Thus, the potential cytolytic function of dNK cells, probably regulated, cannot be ignored. This nascent activity could be manifest in the decidua under special circumstances (e.g., virus infection of the trophoblast or decidual remodeling).. Many other genes overexpressed in dNK cells that are presented in Fig. 3 (e.g., CD31, CD38, MIP-1 α/β, Syk, LEF1, AARS, arp2/3 subunit, and tubulins) may be of considerable interest but are beyond the scope of the present paper. Likewise, genes that are absent or have lower expression in dNK cells in relation to ...
Elevated level of free 8-iso-prostaglandin F2alpha in the decidua basalis of women with preeclampsia. Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia
The part of the chorion that is in contact with the decidua capsularis undergoes atrophy, so that by the fourth month scarcely a trace of the villi is left. This part of the chorion becomes smooth, and is named the chorion laeve (from the Latin word levis, meaning smooth). As it takes no share in the formation of the placenta, this is also named the non-placental part of the chorion. As the chorion grows, the chorion laeve comes in contact with the decidua parietalis and these layers fuse. The villi at the embryonic pole, which is in contact with the decidua basalis, increase greatly in size and complexity, and hence this part is named the chorion frondosum. Thus the placenta develops from the chorion frondosum and the decidua basalis. ...
TY - JOUR. T1 - Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua. AU - Kaituu-Lino, Tuuhevaha J. AU - Ye, Louie. AU - Tuohey, Laura. AU - Dimitriadis, Evdokia. AU - Bulmer, Judith N. AU - Rogers, Peter. AU - Menkhorst, Ellen. AU - Van Sinderen, Michelle Leigh. AU - Girling, Jane Eleanor. AU - Hannan, Natalie J. AU - Tong, Stephen. PY - 2013. Y1 - 2013. N2 - STUDY QUESTION: What is the nature of cellular Corin expression in human gestational tissues? SUMMARY ANSWER: CORIN is expressed in non-pregnant late secretory phase endometrium, first trimester human implantation sites and is up-regulated with decidualization ex vivo. WHAT IS KNOWN ALREADY: Adequate trophoblast invasion and spiral artery remodeling/transformation is critical for successful implantation. CORIN, best known for its role in activating atrial natruietic peptide (ANP) to regulate blood pressure, has recently been proposed to be centrally ...
Looking for online definition of Decidual cells in the Medical Dictionary? Decidual cells explanation free. What is Decidual cells? Meaning of Decidual cells medical term. What does Decidual cells mean?
Tryptophan 2,3-dioxygenase (T do 2) is a rate-limiting enzyme which directs the conversion of tryptophan to kynurenine. The aim of this study was to examine the expression and regulation of T do 2 in mouse uterus during decidualization. T do 2 mRNA was mainly expressed in the decidua on days 6-8 of pregnancy. By real-time PCR, a high level of T do 2 expression was observed in the uteri from days 6 to 8 of pregnancy, although T do 2 expression was observed on days 1-8. Simultaneously, T do 2 mRNA was also detected under in vivo and in vitro artificial decidualization. Estrogen, progesterone, and 8-bromoadenosine-cAMP could induce the expression of T do 2 in the ovariectomized mouse uterus and uterine stromal cells. T do 2 could regulate cell proliferation and stimulate the expression of decidual marker Dtprp in the uterine stromal cells and decidual cells. Overexpression of T do 2 could upregulate the expression of Ahr, Cox2, and Vegf genes in uterine stromal cells, while T do 2 inhibitor 680C91 ...
Decidualization is a process that results in significant changes to cells of the endometrium in preparation for, and during, pregnancy. This includes morphological and functional changes to endometrial stromal cells (ESCs), the presence of decidual white blood cells (leukocytes), and vascular changes to maternal arteries. The sum of these changes results in the endometrium changing into a structure called the decidua. In humans, the decidua is shed during the third phase of birth. Decidualization plays an important role in promoting placenta formation between a mother and her fetus by mediating the invasiveness of trophoblast cells. It also triggers the production of cellular and molecular factors that result in structural changes, or remodeling, of maternal spiral arteries. Decidualization is required in some mammalian species where embryo implantation and trophoblast cell invasion of the endometrium occurs, also known as hemochorial placentation. This allows maternal blood to come into direct ...
The oedematous condition of the decidual stroma is noted in most early ova, but it is usually associated with a certain amount of congestion of the blood vessels throughout the whole decidua. Jung refers particularly to a condition of venous hyperaemia. In my specimen there is no marked congestion in the decidua vera, but merely some enlarged veins here and there. There is in the decidua basalis, especially around the border zone, a noticeable escape of red blood corpuscles into the stroma. This condition is more widespread in my specimen than in ]ungs, where it was confined to the immediate neighbourhood of the border zone. I have not detected anything that could be interpreted as the formation of new capillaries in this zone. This phenomenon is described by Peters, particularly in the capsularis. White blood cells, or at least what appear to be lymphocytes, are to be found in the stroma particularly around the vessels, not only in the decidua basalis but in the vera and capsularis. The ...
Bisphenol A exposure at levels as low as 100 mg/kg/ day can impair embryo implantation and affect decidualization of the uterus in the mouse model.
Nancy P, Tagliani E, Tay CS, Asp P, Levy DE, Erlebacher A. Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science. 2012 Jun 8;336(6086):1317-21. PubMed PMID: 22679098 ...
Light and electron microscopic studies of the human placental bed suggest that the invasion of trophoblast into decidua depends in some measure on interaction with decidual extracellular matrix (Boyd...
Author(s): Kim, Minah; Park, Hyeung Ju; Seol, Jae Won; Jang, Jeon Yeob; Cho, Young-Suk; Kim, Kyu Rae; Choi, Youngsok; Lydon, John P; Demayo, Francesco J; Shibuya, Masabumi; Ferrara, Napoleone; Sung, Hoon-Ki; Nagy, Andras; Alitalo, Kari; Koh, Gou Young | Abstract: The features and regulation of uterine angiogenesis and vascular remodelling during pregnancy are poorly defined. Here we show that dynamic and variable decidual angiogenesis (sprouting, intussusception and networking), and active vigorous vascular remodelling such as enlargement and elongation of vascular sinus folding (VSF) and mural cell drop-out occur distinctly in a spatiotemporal manner in the rapidly growing mouse uterus during early pregnancy - just after implantation but before placentation. Decidual angiogenesis is mainly regulated through VEGF-A secreted from the progesterone receptor (PR)-expressing decidual stromal cells which are largely distributed in the anti-mesometrial region (AMR). In comparison, P4 -PR-regulated VEGF-A
Professor Graham Burton. The role of the endometrial glands during human early pregnancy has largely been ignored once implantation is complete. However, we have recently demonstrated that the glands are an important source of nutrients for the conceptus during the first trimester. The glandular secretions also contain a rich mix of growth factors and cytokines, and so play a role in regulating early placental development, modulating trophoblast proliferation and differentiation. In other species, such as the sheep and rabbit, there is good evidence that the secretions are essential for promoting growth of the conceptus. It is also known that in these species signals from the conceptus increase the production of glandular secretions to meet its demands. Our interests now are to identify how endometrial gland secretions are regulated in human early pregnancy, their composition, and their effects on trophoblast behaviour. The project may tackle one or more of these topics depending on the ...
Preeclampsia is a severe complication that occurs in the third trimester of pregnancy, affecting around 8% of pregnant women. If it is not diagnosed on time, it may lead to significant complications with both the mother and fetus. Until now, most research on the topic had focused on investigating defects in placenta formation that resulted in the onset of the disease, ignoring the role of the maternal uterine tissue where the embryo is implanted.. Our study, first author of which is Dr. Tamara Garrido-Gómez, shows the link between the onset of preeclampsia and a defect in the decidualization process in the endometrium. Decidualization is an endometrial process that entails preparing the uterus for the implantation of the embryo and a successful pregnancy. This defect not only occurs in the endometrium of women who have suffered from preeclampsia during a previous pregnancy, but also in patients who have preeclampsia at the time of birth.. This discovery offers an explanation as to why women ...
European Larch (Larix decidua) tree is a deciduous conifer but often treated as a honorary broadleaf to provide diversity in conifer plantations. The needles turn red then yellow in autumn before falling off.
talk contribs‎ 443 bytes +443‎ Created page with ==Introduction== --~~~~ Currently Template page only. {{Template:Placenta Links}} ==References== ,references/, ===Reviews=== ===Articles=== ===Search PubMed=== Searc… ...
Sonia S. Hassan is the author of this article in the Journal of Visualized Experiments: Isolation of Leukocytes from the Human Maternal-fetal Interface
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Mikročip tehnologija je evoluirala iz saudern blotinga, gde se fragmentisana DNK vezuje za supstrat i zatim se testira poznatom DNK sekvencom.[1] Prva objavljena upotreba ovog pristupa je bila analiza grupe od 378 liziranih bakterijskih kolonija, svaka od kojih je sadržala različitu sekvencu. One su testirane u višestrukim replikatima za ekspresiju gena u više normalnih i tumorskih tkiva.[2] To je zatim prošireno analizom više od 4000 ljudskih sekvenci putem računarom vođenog skeniranja i analize slika za kvantitativnu analizu sekvenci u ljudskim tumorima creva i normalnim tkivima[3]. Oni su zatim poređeni sa tkivima creva sa različitim genetičkim rizikom.[4] Upotreba kolekcije distinktnih DNK uzoraka u nizu za profilisanje ekspresije je takođe opisana 1987, i DNK nizovi su korišćeni za identifikaciju gena čije izražavanje je modulisano interferonom.[5] Ti rani nizovi gena su pravljeni nanošenjem kDNK tačaka na filter papir. Upotreba minijaturnih mikročipova za profilisanje ...
Molekulsko kloniranje je skup eksperimentalnih metoda molekularne biologije koji ise koriste za formiranje molekula rekombinantne DNK i za usmeravanje njene replikacije unutar organizma domaćina.[1] Reč kloniranje se koristi jer metod vrši replikaciju jednog molekula DNK počevši od jedne ćelije i generiše veliku popolaciju ćelija koje sadrže identične DNK molekule. Molekularno kloniranje generalno koristi DNK sekvence dva različita organizma: vrste koja je izvor DNK koja se klonira i vrste koja služi kao živi domaćin za replikaciju rekombinantne DNK. Metodi molekularnog kloniranja su centralni za mnoge savremene oblasti biologije i medicine.[2] U konvencionalnom eksperimentu molekulskog kloniranja, DNK koja se klonira se dobija iz željenog organizma, i zatim se tretira sa enzimima u epruveti da bi se formirali manji fragmenti. Naknadno se ti fragmenti kombinuju sa DNK vektorom da bi se formirali rekombinantni DNK molekuli. Oni se zatim uvode u organizam domaćina (tipično u ...
Endometriosis is a common gynaecological disorder characterised by heterotopic islands of uterine mucosa found in many locations, mainly in the pelvis.
The actions of relaxin are highly species specific. The role of relaxin in human endometrial function has not been well understood because of the paucity of in vivo studies in women or in suitable primate models. A model of early human pregnancy was
The voltaic cell reaction NiO2(s)+4H^+(aq)+ 2Ag(s)-->Ni^2+(aq)+2H20(l)+ 2Ag^+ has a E cell= +2.48V. What will the cell potential be at a pH of 5.00 when the concentration of NiO^2+ and Ag^+??? I need to know how to set this type of problem up to solve it ...
Mountains of northwest United States and southwest Canada, at lower altitudes (Pacific Northwest). Larix decidua Mill. (syn. L ... decidua and L. kaempferi hybridised when planted together, is still treated as unresolved. Larix × stenophylla Sukaczev is ...
Capparis decidua Pax.), Mallah (Zizyphus nummularia W&A.), Ber (Zizyphus mauritiana Lamk.), Chamror (Ehretia laevis Roxb.), ...
Chorioamnionitis Decidua Edmondson, N.; Bocking, A.; Machin, G.; Rizek, R.; Watson, C.; Keating, S. (2009). "The prevalence of ... decidua). It is associated with preterm labour. The diagnosis rests primarily on the presence of plasma cells. Intermed. mag. ...
olgensis and Larix decidua. It is considered an important pest of larch. Trees are completely defoliated when outbreaks occur. ...
formosana Larix decidua var. polonica Picea alcoquiana var. acicularis Picea alcoquiana var. reflexa Picea asperata var. ... cochranei Magnolia coriacea Magnolia crassipes Magnolia cristalensis Magnolia dawsoniana Magnolia decastroi Magnolia decidua ...
... can refer to: Larix europaea DC., a synonym of Larix decidua var. decidua Larix europaea Middend., a synonym of ...
... indigenous Ceropegia decidua E.A.Bruce subsp. decidua, indigenous Ceropegia decidua E.A.Bruce subsp. pretoriensis R.A.Dyer, ... Curroria decidua Planch. ex Benth. subsp. decidua, accepted as Cryptolepis decidua (Planch. ex Benth.) N.E.Br. present Genus ... indigenous Cryptolepis cryptolepioides (Schltr.) Bullock, indigenous Cryptolepis decidua (Planch. ex Benth.) N.E.Br. indigenous ... crassifolia, indigenous Ceropegia cycniflora R.A.Dyer, endemic Ceropegia decidua E.A.Bruce, ...
Instead, it remains as decidua. The decidua becomes part of the placenta; it provides support and protection for the gestation ...
Larix decidua). ^ The flight season refers to Belgium and The Netherlands. This may vary in other parts of the range. Seitz, A ...
Wrightia natalensis Stapf Cryptolepis decidua (Planch. ex Hook.f. & Benth.) N.E.Br. Ectadium latifolium (Schinz) N.E.Br. ...
The larvae feed on Larix decidua. Larvae can be found from August to May of the following year. Fauna Europaea Junnilainen, J. ...
The larvae feed on Larix decidua. Fauna Europaea Ukmoths lepiforum.de v t e. ...
The larvae feed on Larix decidua. "Argyresthia (Blastotere) tatrica Baraniak, Kulfan & Patocka, 2003". Fauna Europaea. 2.6.2. ... n. (Lepidoptera, Yponomeutidae, Argyresthiinae) - a new Lepidoptera species feeding on Larix decidua in the Tatra Mts". ...
Over 50 articles! Chemicals, translations and the arts.... is there such a thing as a wikimath? Anyway thanks from me and the wiki. Oh and can I tell you that the 100 medal is really nice colour of gold ... Victuallers (talk) 15:27, 1 March 2009 (UTC ...
Latin: Pinophyta; Lithuanian: Pušūnai) European Larch (Latin: Larix decidua; Lithuanian: Europinis maumedis) Norway Spruce ( ...
Section through ovum imbedded in the uterine decidua. Embryo between eighteen and twenty-one days. Human embryo about fifteen ...
sexmaculata feed on Larix laricina and Larix decidua. Larvae of ssp. incolorata have been recorded on Larix occidentalis and ...
Shaw KJ, Ng C, Kovacs BW (1994). "Cyclooxygenase gene expression in human endometrium and decidua". Prostaglandins Leukot. ...
The fruit of other species, such as karir (C. decidua), are also used for cooking; C. mitchellii and the Wild passionfruit (the ... Ixias marianne (white orangetip) - recorded on C. grandis, C. sepiaria, C. decidua, and C. divaricata. Leptosia nina (psyche ... Capparis cynophallophora L. - Jamaican caper Capparis decidua (Forssk.) Edgew. (= C. aphylla) - karir (kirir, k(h)air, karril, ... decidua - are highly useful in landscape gardening, afforestation and reforestation. They can stop soil erosion and preserve ...
The decidua here is termed the decidua basalis; it lies between the blastocyst and the myometrium and forms the maternal part ... Arteries in the decidua are remodelled to increase the maternal blood flow into the intervillous spaces of the placenta, ... This lining of the uterine cavity (or womb) is now known as the decidua, and it produces a great number of large decidual cells ...
Bradbury JT, Long RC, Durham WC (1953). "Progesterone and estrogen requirements to induce and maintain decidua". Fertil. Steril ...
decidua (the deciduous fence aloe), type: Alice, Eastern Cape. A small, erect, deciduous variety. The most common colour form ...
Larix decidua) European Pear (Pyrus communis; sometimes regarded as native) Plymouth Pear (Pyrus cordata; sometimes regarded as ...
Scrublands are dominated by ber and kair (Capparis decidua). Piloo (Salvadora oleoides and Salvadora persica) also present in ...
... decidua Fuchsia fulgens Fuchsia splendens F. splendens var. splendens F. splendens var. cordifolia Mexico to Panama. ...
Occurrence of phospholipase A1 and A2 in human decidua". Prostaglandins. 9 (5): 667-73. doi:10.1016/0090-6980(75)90106-9. PMID ...
Uvaria decaryana Cavaco & Keraudren Uvaria decidua Diels Uvaria denhardtiana Engl. & Diels Uvaria dependens Engl. & Diels ...
The sum of these changes results in the endometrium changing into a structure called the decidua. In humans, the decidua is ... One of the identifying features of the decidua is the presence of large numbers of leukocytes that are mostly made up of ... Decidua Decidual cells Decidual reaction Pansky, Ben (1982-08-01). Review of Medical Embryology. McGraw-Hill. ISBN ... After implantation of the embryo, the decidua further develops to mediate the process of placentation. In the event no embryo ...
... or decidua, the uterine lining that sheds off after birth. In botany and horticulture, deciduous plants, including trees, ...
The 4th instar larva on Larix decidua Miller (Pinaceae); 11. Last instar larva with darker brown head; 12. Mature larva on ... The larvae feed on various plants, including Andromeda polifolia, Salix phylicifolia, Larix gmelini, Larix decidua and Larix ...
Larix decidua. (as syn.. Larix europaea). plate 155 in:. Wayside and woodland blossoms,. 1895,. page 317. alternative. ... Larix decidua. (as syn.. Larix europaea). plate 155 in:. Wayside and woodland blossoms,. 1895,. page 317. ... Retrieved from "https://commons.wikimedia.org/w/index.php?title=Larix_decidua&oldid=279489837" ...
The remainder of the decidua is termed the decidua parietalis or decidua vera, and it will fuse with the decidua capsularis by ... The part of the decidua that interacts with the trophoblast is the decidua basalis (also called decidua placentalis), while the ... Decidua in a lymph node may mimic metastatic carcinoma. A long-lasting infection of the decidua, chronic deciduitis, is ... The decidua forms the maternal part of the placenta and remains for the duration of the pregnancy. It is shed off during ...
Decidua menstrualis is the diffuse hyperplasia of the decidua of the uterus in the absence of a demonstrable pregnancy. In ... Decidua mensrtualis may be wrongly diagnosed in individuals who do not present the clinical history of recent abortion. Ober, W ... The probable cause of decidua menstrualis is pathologically prolonged progestin stimulation in the absence of a preceding ... B.; Grady, H. G.; Schoenbucher, A. K. (1957). "Ectopic ovarian decidua without pregnancy". The American Journal of Pathology. ...
2) analyzed the transcriptome of decidua basalis (DB) and decidua parietalis (DP) using a laser-microdissection approach in a ... Transcriptional signature of the decidua in preeclampsia. Ji-Long Liu, Wen-Qian Zhang, and Ming-Yu Huang ... 2011) A transcriptional profile of the decidua in preeclampsia. Am J Obstet Gynecol 204:84.e1-84.e27. ... In conclusion, we suggest that the transcriptional signature of the decidua in preeclampsia should be tested in a larger set of ...
Decidua placentalis synonyms, Decidua placentalis pronunciation, Decidua placentalis translation, English dictionary definition ... of Decidua placentalis. n. pl. de·cid·u·as or de·cid·u·ae A mucous membrane lining the uterus, modified during pregnancy and ... Related to Decidua placentalis: decidua capsularis, decidua vera, decidual reaction, decidua parietalis, Deciduum ... decidua. (redirected from Decidua placentalis). Also found in: Thesaurus, Medical, Encyclopedia. ...
... Diagrammatic sections of the uterine mucous membrane: A. The non-pregnant uterus. B. The pregnant uterus. ... That part of the decidua that interacts with the trophoblast is the decidua vera ("true decidua"). The remainder of the decidua ... Decidua Decidua is the term for the uterine lining (endometrium) during a pregnancy, which forms the maternal part of the ... The decidua secretes hormones, growth factors, and cytokines. It has receptors for estrogen, progesterone, growth hormone, and ...
... decidua x leptolepis, the hybrid possessed an above-ground biomass which was three times greater, although all larches ... Among 33-year-old forest trees of Larix decidua, L. leptolepis and L. ... Among 33-year-old forest trees ofLarix decidua, L. leptolepis andL. decidua x leptolepis, the hybrid possessed an above-ground ... Matyssek R, Schulze E-D (1987) Heterosis in hybrid larch (Larix decidua x leptolepis). I. The role of leaf characteristics. ...
Isolation of Decidua and Peripheral Blood Lymphocytes. Decidua cell suspensions were prepared from decidua tissues by a ... However, the percentage of CD56+CD16-NK cells in the decidua at term is lower than that of the first-trimester decidua. This ... 10.7 in decidua and peripheral blood, respectively (Figure 4). In both cases, the values in the decidua appear to be lower than ... and the cytokine production of NK cells in term placenta decidua and peripheral blood. Methods. Term decidua and peripheral ...
Larix decidua is a deciduous Tree growing to 45 m (147ft) by 15 m (49ft) at a fast rate. It is hardy to zone (UK) 4 and is not ... Larix decidua is a deciduous Tree growing to 45 m (147ft) by 15 m (49ft) at a fast rate.. It is hardy to zone (UK) 4 and is not ... approve Larix decidua for fevers & colds, coughs/bronchitis, tendency to infection, blood pressure problems, inflammation of ...
Larix decidua Mill.. Taxonomic Serial No.: 183410 (Download Help) Larix decidua TSN 183410 ...
Vigorous, upright, deciduous shrub, native to the Southeast. Small, lustrous green leaves with scalloped margins come in late spring. Profuse, scarlet-red
... decidua capsularis explanation free. What is decidua capsularis? Meaning of decidua capsularis medical term. What does decidua ... Looking for online definition of decidua capsularis in the Medical Dictionary? ... parietal decidua (decidua parieta´lis) (true decidua) (decidua ve´ra) the decidua exclusive of the area occupied by the ... Related to decidua capsularis: decidua basalis, decidua parietalis, decidua vera. decidua. [de-sid´u-ah] a name applied to the ...
The presence of gonadotropin receptors in nonpregnant human uterus, human placenta, fetal membranes, and decidua.. Reshef E1, ... At term pregnancy, while receptors in fetal membranes and decidua continue to be detected, placental tissues did not show any ... There were more receptors in decidua than in fetal membranes at mid- and term pregnancy. While the amniotic epithelial ... In summary, hCG/LH receptors were demonstrated in the nonpregnant human uterus, human placenta, fetal membranes, and decidua. ...
Decidua is a graceful cedar that has a conical shape and long, stiff needles with barrel-shaped cones. It has congested ... Cultivar: Decidua Family:Pinaceae Size:Height: 0 ft. to 0 ft.. Width: 0 ft. to 0 ft. Plant Category:landscape, perennials, ... The cultivar, Decidua is a graceful cedar that has a conical shape and long, stiff needles with barrel-shaped cones. It has ...
Larix decidua, commonly called European or common larch, is a deciduous conifer although it looks like a needled evergreen in ...
Ilex decidua) supplied by member gardeners in the ... ... decidua. A pretty easily-missed tree at other times of the year ...
Decidua Parietalis T Cells Display a More Activated Phenotype Compared to Decidua Basalis. As demonstrated by the OPLS-DA in ... Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua ... Decidua parietalis contained a higher proportion of both effector memory and central memory CD4+ T cells compared to decidua ... The decidua can be divided into two anatomically different parts; the decidua basalis covers the basal plate of the placenta, ...
Light and electron microscopic studies of the human placental bed suggest that the invasion of trophoblast into decidua depends ... 1974) Ultrastructural development of the human decidua. Am. J. Obstet. Gynecol.118, 652-670.PubMedGoogle Scholar ... Aplin J.D., Charlton A.K. (1990) The Role of Matrix Macromolecules in the Invasion of Decidua by Trophoblast: Model Studies ... Aplin, J.D., Jones, C.J.P. (1989) Extracellular matrix in endometrium and decidua. In: Placental- And Decidual-Specific Protein ...
CXCL1 expression in human decidua in vitro is mediated via the MAPK signalling cascade.. [Dunja Maria Baston-Büst, Andrea ... So far nothing is known about the signalling cascades of CXCL1 expression in human decidua. The aim of the study was to ... identify signalling cascades mediating the CXCL1 expression in human decidua incubated with IL-1β as a major secretion product ...
... γ4 and γ5 chains and oligoclonal and highly restricted CDR3γ9 repertoire of γδ T cells in the decidua and blood of pregnant ... of activated and terminally differentiated pro-inflammatory γδ T-cell effectors with specific location in the human decidua ... Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with ... "Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with ...
... in the placenta and decidua basalis was revealed by RNA-Seq with CpG ODN or control ODN treatment. Common DEGs in the WT and ... Transcriptomic Insights into the Response of Placenta and Decidua Basalis to the CpG Oligodeoxynucleotide Stimulation in Non- ... "Transcriptomic Insights into the Response of Placenta and Decidua Basalis to the CpG Oligodeoxynucleotide Stimulation in Non- ... in the placenta and decidua basalis was revealed by RNA-Seq with CpG ODN or control ODN treatment. Common DEGs in the WT and ...
Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. ... Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. ...
... 1.The formation of a specialised decidua from endometrium the normal lining of the non- ... Role of the Human Decidua. At the maternal interface to the embryo the decidua participates in the exchanges of nutrition, gas ... 1. Human Decidua and Decidualisation, from Wikipedia the free encyclopedia.. 2. DUNN C L, KELLY R N, CRITCHLEY H D. ... Further the decidua has to allow a very controlled invasion by the trophoblast (1). 2. Changes in human endometrium are ...
... decidua Best Plays of decidua in Scrabble® and Words With Friends, Length tables of words in decidua, Word growth of decidua, ... Definition of decidua. "decidua" in the noun sense. 1. decidua. the epithelial tissue of the endometrium ... decidua. in Words With Friends™. The word decidua is playable in Words With Friends™, no blanks required. ... decidua. in Scrabble®. The word decidua is playable in Scrabble®, no blanks required. ...
... the decidua capsularis, a thin layer that covers the embryo; the decidua basalis, where the embryo is attached; and the decidua ... Traumatic resin ducts in Larix decidua stems impacted by debris flows Endometriosis also affects the decidua in contact with ... Cytokine secretion by human fetal membranes, decidua and placenta at term. Immunoregulatory activity of decidua in spontaneous ... Expression of interleukin-15 in human endometrium and decidua Uterine natural killer cells pace early development of mouse ...
The results showed that the cream prepared from the local desert plant C. decidua had the ability to produce Antisebum effects ... One was the formulation in which 5% extract obtained from the plant Capparis decidua was added during the preparation of the ... Key words: Antisebum, extract, Capparis decidua, Sebumeter, Sebum. ... Development of a sebum control cream from a local desert plant Capparis decidua. Shahiq uz Zaman1*, Naveed Akhtar1, Barkat Ali ...
... decidua is subdivided into 3 segments: basal decidua between the implanted embryo and the uterine myometrium, capsular decidua ... Degeneration of the capsular decidua is followed by fusion of smooth chorion with the parietal decidua, resulting in the almost ... We reasoned that to reach stroma of parietal decidua schCTBs should penetrate the capsular decidua (stroma and uterine ... The role of chorionic cytotrophoblasts in the smooth chorion fusion with parietal decidua. Olga Genbacev,a,b,c Ljiljana Vicovac ...
Download European Larch Larix decidua, Stallen Valley, Karwendel Mountains, Tyrol, Austria, Europe Stock Photos. Search over 12 ... Stock Photo: European Larch Larix decidua, Stallen Valley, Karwendel Mountains, Tyrol, Austria, Europe. ...
B) Immunohistochemical expression of VEGF in the decidua at 14 DG with increased VEGF immunostaining intensity in the decidua ... B) Immunohistochemical expression of VEGF in the decidua at 14 DG with increased VEGF immunostaining intensity in the decidua ... Immunohistochemical expression of Flk-1 in the decidua at 14 DG with increased immunostaining intensity of Flk-1 in the decidua ... Immunohistochemical expression of Flk-1 in the decidua at 14 DG with increased immunostaining intensity of Flk-1 in the decidua ...
Decidua and implantation of the embryo from a historical perspective. Ivan Damjanov* ...
  • Among 33-year-old forest trees of Larix decidua, L. leptolepis and L. decidua x leptolepis , the hybrid possessed an above-ground biomass which was three times greater, although all larches displayed similar relative distributions of biomass. (springer.com)
  • Matyssek R, Schulze E-D (1987) Heterosis in hybrid larch ( Larix decidua x leptolepis ). (springer.com)
  • Larix decidua is a deciduous Tree growing to 45 m (147ft) by 15 m (49ft) at a fast rate. (pfaf.org)
  • The German Commission E Monographs, a therapeutic guide to herbal medicine, approve Larix decidua for fevers & colds, coughs/bronchitis, tendency to infection, blood pressure problems, inflammation of mouth and pharynx, common cold (see [302] for critics of commission E). (pfaf.org)
  • Larix decidua , commonly called European or common larch, is a deciduous conifer although it looks like a needled evergreen in summer. (missouribotanicalgarden.org)
  • european larch (larix decidua), tree line at app 2350m, growing on the lateral morain of the glacier position of 1850. (superstock.com)
  • An Larix decidua in nahilalakip ha genus nga Larix , ngan familia nga Pinaceae . (wikipedia.org)
  • The European Larch (Larix decidua) is a quick growing tree, capable of reaching up to 40m. (treesbypost.co.uk)
  • Germination Percentage and Germination Speed of European Larch (Larix decidua Mill. (ingentaconnect.com)
  • Ilex decidua var. (davesgarden.com)
  • Photo 1127-10: Possum-haw holly (deciduous yaupon, Ilex decidua. (asergeev.com)
  • Possum-haw holly (deciduous yaupon, Ilex decidua) in Birch Creek Unit of Somerville Lake State Park. (asergeev.com)
  • To elucidate the molecular mechanisms of differential pregnancy outcomes, differentially expressed genes (DEGs) in the placenta and decidua basalis was revealed by RNA-Seq with CpG ODN or control ODN treatment. (mdpi.com)
  • Abstract The placenta and decidua interact dynamically to enable embryonic and fetal development. (bibf1120.com)
  • This research offers a blueprint to help expand the knowledge of the jobs of the cells in the placenta and decidua for maintenance of early gestation aswell as pathogenesis in pregnancy-related disorders. (bibf1120.com)
  • Further, the decidua has to allow a very controlled invasion of the trophoblast. (bionity.com)
  • The part of the decidua that interacts with the trophoblast is the decidua basalis (also called decidua placentalis), while the decidua capsularis grows over the embryo on the lumenal side, enclosing it into the endometrium. (wikipedia.org)
  • Pathophysiology of placenta creta: the role of decidua and extravillous trophoblast. (semanticscholar.org)
  • Tnfrh1 mRNA is detectable in multiple adult and fetal tissues, with highest expression in placenta, where in situ hybridization reveals a distinctive population of Tnfrh1 -positive cells in maternal decidua, directly beneath the trophoblast giant cells. (biomedcentral.com)
  • In view of its strong expression in cells at the fetal-maternal boundary, Tnfrh1 warrants further study as a gene that might modulate immune or trophic interactions between the invasive placental trophoblast and the maternal decidua. (biomedcentral.com)
  • Vertical transmission during pregnancy can occur on distinct boundaries between the mother and the fetus: (i) the intervillous space (IVS), where placental villi is in direct contact with the maternal blood, (ii) the implantation site or decidua basalis, where maternal cells are in direct contact with the invading fetal trophoblast, and (iii) the fetal membranes, which are in direct contact with the uterine cavity ( 5 ). (frontiersin.org)
  • Major cell types of placenta trophoblast and decidua from Vento-Tormo et al. (frontiersin.org)
  • Cytotoxic activity against trophoblast and choriocarcinoma cells of large granular lymphocytes from human early pregnancy decidua. (ox.ac.uk)
  • dNK cells play a crucial role in successful placentation probably by orchestrating the invasion of trophoblast cells deep into the decidua basalis and remodeling of the maternal spiral arteries. (nih.gov)
  • 2 ) analyzed the transcriptome of decidua basalis (DB) and decidua parietalis (DP) using a laser-microdissection approach in a small number of samples ( n = 4). (pnas.org)
  • The remainder of the decidua is termed the decidua parietalis . (bionity.com)
  • it becomes progressively attenuated as the chorionic vesicle enlarges and, by the fourth month, is squeezed against the decidua parietalis and thereafter undergoes rapid regression. (thefreedictionary.com)
  • Decidua parietalis lymphocytes displayed a more activated phenotype with a higher expression of coinhibitory markers than those isolated from basalis and contained higher frequencies of T regulatory cells. (hindawi.com)
  • To conclude, leukocytes in decidua basalis and parietalis displayed remarkable phenotypic disparities, indicating that the corresponding stromal microenvironments provide different immunoregulatory signals. (hindawi.com)
  • the decidua basalis covers the basal plate of the placenta, while the decidua parietalis lines the fetal membranes. (hindawi.com)
  • Decidual stromal cells (DSCs) make up the foundation of the connective structures of both decidua basalis and parietalis and have been shown to utilize a specific epigenetic program of gene silencing in order to minimize the attraction of maternal effector T cells in mice [ 2 ]. (hindawi.com)
  • and the decidua parietalis , which is not in contact with the embryo. (oup.com)
  • The remainder of the decidua is termed the decidua parietalis or decidua vera, and it will fuse with the decidua capsularis by the fourth month of gestation. (wikipedia.org)
  • Eventually the decidua capsularis merges with the decidua parietalis, obliterating the uterine cavity. (umich.edu)
  • The decidua has a histologically -distinct appearance, displaying large polygonal decidual cells in the stroma. (bionity.com)
  • The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. (hindawi.com)
  • Ectopic decidua is defined as extrauterine deposits of decidual stromal cells. (scienceopen.com)
  • SUMMARY ANSWER: The onset of parturition, both at term and preterm, is associated with widespread gene expression changes in the decidua, many of which are related to inflammatory signalling, but is not associated with changes in the number of any of the decidual lymphocyte populations examined. (bris.ac.uk)
  • Using flow cytometry and microarray analysis, the present study aimed to investigate changes to the immune cell milieu of the decidua in association with the onset of parturition and define the decidual gene signature associated with term and preterm labour (PTL). (bris.ac.uk)
  • In order to understand the role of decidua in this endometrial invasion by trophoblastic cells, we have developed a model of coculture of decidual and cytotrophoblastic cells in which we can evaluate the effect of each partner on the proliferative and invasive properties of the other. (nel.edu)
  • Engrafted pregnant females have restoration of the uNK cell population, induced metrial gland differentiation, reduced anomalies in the decidua and decidual blood vessels, increased placental sizes, and restoration of fetal viability at all gestational days studied (days 10, 12, and 14). (rupress.org)
  • By day 10 of gestation, the decidua lacks normal cellularity and the large ablumenal decidual blood vessels have thickened walls. (rupress.org)
  • Cell types of the decidua Graph-based clustering analysis identified 11 unique cell clusters characterized by the expression of lineage markers specific for decidualized stromal cells (DSCs), two unique decidual FB populations (FB1 and FB2), simple muscles cells (SMCs), endometrial epithelial cells (EECs), two populations of organic killer cells (NK1 and NK2), antigen-presenting cells (APCs), T cells (TCs), lymphatic endothelial cells (LECs), and VECs (Fig. 2A). (bibf1120.com)
  • Here, we outline the anatomy of the human placenta and uterine lining, the decidua, and discuss the potential capacity of pathogen pattern recognition and other host defense strategies present in the innate immune cells at the placental-decidual interface. (frontiersin.org)
  • Abruptions were associated with a marked decidual neutrophil infiltration that peaked after PPROM, whereas decidua from gestational age-matched controls were virtually devoid of neutrophils. (unisi.it)
  • Flow cytometric characterisation of cell populations in human pregnancy decidua and isolation of decidual macrophages. (ox.ac.uk)
  • Decidua is the term for the uterine lining ( endometrium ) during a pregnancy , which forms the maternal part of the placenta. (bionity.com)
  • Mature NK cells, which are present in peripheral blood, make up almost all NK cells, and, in the decidua, there is a large amount of immature NK cells that are known as uterine NK cells [ 17 - 19 ]. (hindawi.com)
  • capsular decidua ( decidua capsula´ris ) that portion directly overlying the implanted ovum and chorion, facing the uterine cavity. (thefreedictionary.com)
  • menstrual decidua ( decidua menstrua´lis ) the hyperemic uterine mucosa shed during menstruation. (thefreedictionary.com)
  • Here, we provided evidence that the mechanism by which smooth chorion fuses with parietal decidua is the invasion of smooth chorionic cytotrophoblasts (schCTBs) into the uterine wall opposite to the implantation side. (pubmedcentralcanada.ca)
  • Direct maternal-fetal interaction occurs both in the uterine wall decidua and at the placental surface and these aligned sites constitute the maternal-fetal interface. (uib.no)
  • This study aimed to investigate cholesterol crystal accumulation and NLRP3 inflammasome expression by maternal and fetal cells in the uterine wall decidua of normal and preeclamptic pregnancies. (uib.no)
  • The innate immune system is likely to offer protection against Chlamydia and the natural anti-microbial proteins, secretory leukocyte protease inhibitor (SLPI) and elafin, are key mediators of the innate immune system and are expressed throughout the genital tract, including the uterine decidua. (endocrine-abstracts.org)
  • To compare elafin and SLPI expression in the decidua of women with ectopic to women with intra-uterine pregnancies. (endocrine-abstracts.org)
  • Rupture of the decidua basalis and release of embryos under resorption in the uterine lumen: a necessary step to escape the immune privileged implantation site? (ovid.com)
  • Angiotensinogen Thr235 variant is associated with abnormal physiologic change of the uterine spiral arteries in first-trimester decidua. (semanticscholar.org)
  • The maternal uterine endometrium stromal cells (fibroblast-like) are transformed by steroid hormones (progesterone) and embryonic signals into the decidua. (edu.au)
  • The uterine lining which is formed as the maternal part of the placenta during the pregnancy is known as Decidua. (womenhealthzone.com)
  • The uterine mucosal lining, the endometrium, is transformed into the decidua during early pregnancy ( 2 ). (frontiersin.org)
  • At a "relative growth rate" slightly lower than in the parent species, hybrid larch achieved twice the annual carbon gain, increment in stem length and above-ground production, and its foliage-related stem growth was higher than in European ( L. decidua) but similar to Japanese ( L. leptolepis ) larch. (springer.com)
  • At term pregnancy, while receptors in fetal membranes and decidua continue to be detected, placental tissues did not show any detectable receptors unless the tissues were pretreated with neuraminidase. (nih.gov)
  • To compare four enzymatic protocols for mesenchymal stem cells (MSCs) isolation from amniotic (A-MSC) and chorionic (C-MSC) membranes, umbilical cord (UC-MSC) and placental decidua (D-MSC) in order to define a robust, practical and low-cost protocol for each tissue. (springer.com)
  • The umbilical cord (b), amniotic membrane (c), chorionic membrane and placental decidua (d) were separated. (springer.com)
  • Amniotic membrane (e), chorionic membrane (f), placental decidua (g) and umbilical cord (h). (springer.com)
  • Supplementary Table 1-Immunophenotype comparison of MSCs (P3-P5) derived from amniotic membrane (A-MSC), chorionic membrane (C-MSC), placental decidua (D-MSC) and umbilical cord (UC-MSC) using different protocols, analyzed by flow cytometry. (springer.com)
  • Supplementary Fig. 3-A representative example of differentiation capacity (P3-P5) of cells isolated from amniotic membrane (A), chorionic membrane (C), placental decidua (D) and umbilical cord (UC). (springer.com)
  • As the embryo enlarges, the decidua capsularis becomes stretched and smooth. (umich.edu)
  • The fetus, umbilical cord (UC), and placenta are encased by the decidua, a maternal membrane originating from differentiated endometrial cells in early pregnancy [ 1 ]. (hindawi.com)
  • We found an enrichment of activated and terminally differentiated pro-inflammatory γδ T-cell effectors with specific location in the human decidua during early pregnancy, while no significant changes in their counterparts in the blood of pregnant women were observed. (mdpi.com)
  • Furthermore, this difference could be exploited to provide the clinical pathologist with a means of diagnosing ectopic pregnancy in any woman with a failing early pregnancy in whom the diagnosis is uncertain, by simply examining a sample of the decidua. (endocrine-abstracts.org)
  • PGE2 and PGF2 alpha were isolated from the decidua of an early pregnancy, following medical termination. (meta.org)
  • The hallmark of human early pregnancy is the accumulation of a unique population of Natural Killer (dNK) cells at the main maternal-fetal interface, the decidua basalis . (nih.gov)
  • As the maternal interface to the embryo the decidua participates in the exchanges of nutrition, gas, and waste with the gestation. (bionity.com)
  • The aim of the study was to identify signalling cascades mediating the CXCL1 expression in human decidua incubated with IL-1β as a major secretion product of the embryo. (sigmaaldrich.com)
  • LIF and its receptor β (LIF-Rβ) expression in the decidua and chorionic villi were analyzed by semi-quantitative reverse transcription and polymerase chain reaction (RT-PCR), real-time quantitative PCR and immunohistochemical study. (elsevier.com)
  • The presence of gonadotropin receptors in nonpregnant human uterus, human placenta, fetal membranes, and decidua. (nih.gov)
  • In summary, hCG/LH receptors were demonstrated in the nonpregnant human uterus, human placenta, fetal membranes, and decidua. (nih.gov)
  • Expression of glucocorticoid receptor isoforms in term human fetal membranes and decidua. (edu.au)
  • basal decidua ( decidua basa´lis ) that portion lying under the implanted ovum and chorion. (thefreedictionary.com)
  • parietal decidua ( decidua parieta´lis ) ( true decidua ) ( decidua ve´ra ) the decidua exclusive of the area occupied by the implanted ovum and chorion. (thefreedictionary.com)
  • Little is known about the formative stages of the human chorion, in particular the steps between the formation of a smooth chorion and its fusion with the parietal decidua. (pubmedcentralcanada.ca)
  • Acute choriodeciduitis, with neutrophils seen in the chorion and decidua. (wikipedia.org)
  • There were more receptors in decidua than in fetal membranes at mid- and term pregnancy. (nih.gov)
  • Mechanisms of Abruption-Induced Premature Rupture of the Fetal Membranes: Thrombin-Enhanced Interleukin-8 Expression in Term Decidua. (unisi.it)
  • Role of decidua in trophoblastic invasion. (nel.edu)
  • Cohen M, Wuillemin C, Irion O, Bischof P. Role of decidua in trophoblastic invasion. (nel.edu)
  • Aplin, J.D., Jones, C.J.P. (1989) Extracellular matrix in endometrium and decidua. (springer.com)
  • the decidua of the endometrium of the uterus covering the implanted ovum. (thefreedictionary.com)
  • 1.The formation of a specialised decidua from endometrium the normal lining of the non- pregnant uterus is called decidualisation (1). (pregnancysicknesssupport.org.uk)
  • The decidua is the modified mucosal lining of the uterus (that is, modified endometrium) that forms in preparation for pregnancy. (wikipedia.org)
  • The endometrium (lining of the uterus) of the mother is known as the decidua ( cast off ), consisting of three regions named by location. (umich.edu)
  • RA levels in whole decidua correlated with M2 cell density but not with stromal cell (CD10 + ) number, the major cell type comprising the decidua. (researchsquare.com)
  • Human decidua basalis mesenchymal stem/multipotent stromal cells (DBMSCs) inhibit endothelial cell activation by inflammation induced by monocytes. (biomedcentral.com)
  • In immune-competent mice, the metrial gland is associated with the maternal portion of the placenta that consists of transformed stromal cells known as the decidua. (rupress.org)
  • The lymphocytes were separated using density gradient centrifugation (DGC) from peripheral blood and were separated from decidua using DGC after enzyme digestion. (hindawi.com)
  • Large granular lymphocytes (LGL) are the most abundant cell type in first trimester human pregnancy decidua. (ox.ac.uk)
  • In term decidua, 47% of the cells were of bone marrow origin, comprising 18% macrophages, 3% large granular lymphocytes and 8% T cells. (ox.ac.uk)
  • CTB secrete factors that favour invasion whereas decidua seems not to play a major role in regulating CTB invasion in vitro. (nel.edu)
  • Pregnancy-associated ectopic decidua (deciduosis) of the greater omentum. (scienceopen.com)
  • Ectopic decidua (deciduosis) of the omentum was investigated in biopsies taken during cesarean sections and in tubal pregnancies in 60 cases. (scienceopen.com)
  • An ectopic decidua of various abdominal organs was present in 48 further cases. (scienceopen.com)
  • As pregnancy-associated mesenchymal metaplasias, ectopic decidua, fibrosing deciduosis and leiomyomatosis peritonealis disseminata depend on hormone and may regress post partum. (scienceopen.com)
  • Ectopic decidua although uncommon, may present a diagnostic dilemma. (ispub.com)
  • Little is known about endometriosis and subsequent development of ectopic decidua. (ispub.com)
  • Ectopic decidua and metastatic squamous carcinoma: presentation in a single pelvic lymph node. (ispub.com)
  • Intraperitoneal bleeding from ectopic decidua following hormonal contraception. (ispub.com)
  • 7. Buttner A, Bassler R, Theele C. Pregnancy- associated ectopic decidua (deciduosis) of greater omentum. (ispub.com)
  • To investigate the changes in the maternal immune system at term pregnancy, we studied the expression of natural cytotoxicity receptors (NCRs) and the cytokine production of NK cells in term placenta decidua and peripheral blood. (hindawi.com)
  • Marlin R reported on NCR manifestations, such as NKp46, NKp30, NKp44, and NKG2D of CD56+CD3- NK cells in the decidua during the first trimester of pregnancy [ 9 ]. (hindawi.com)
  • Decidua basalis contained higher proportions of monocytes, B cells, and mucosal-associated invariant T (MAIT) cells. (hindawi.com)
  • Our spectratyping data revealed polyclonal CDR3 repertoires of the δ1, δ2 and δ3 chains and γ2, γ3, γ4 and γ5 chains and oligoclonal and highly restricted CDR3γ9 repertoire of γδ T cells in the decidua and blood of pregnant women. (mdpi.com)
  • Natural killer cells and HLA-G expression in the basal decidua of human placenta adhesiva. (semanticscholar.org)
  • To identify the primary RA-producing cells in human term decidua, we isolated cells from decidua basalis of delivered placenta and quantified cellular retinal dehydrogenase (RALDH) activity, a major biosynthetic enzyme whose activity determines the synthesis of RA from retinol, using an Aldefluor assay and flow cytometry. (researchsquare.com)
  • With increasing duration of pregnancy, there was vacuolar degeneration and fragmentation of the decidua cells as a manifestation of regressive changes. (scienceopen.com)
  • Vacca, P. / Group 3 innate lymphoid cells regulate neutrophil migration and function in human decidua . (elsevier.com)
  • Depp increased the level of phosphorylated Erk and activated the Elk-1 transcription factor in human embryonal kidney 293 cells, suggesting that Depp modulates the effects of progesterone during decidualization and in the decidua by affecting gene expression. (nih.gov)
  • Leukocytes (NK1, NK2, APCs, and TCs) had been accounted for 40.4% of cells in the decidua, and the rest of the cells were 4.9% EEC, 2.1% LEC, and 3.9% VEC. (bibf1120.com)
  • EVT-decidua interface represents the interface between EVT and maternal decidua cells. (frontiersin.org)
  • At 10, 14 and 19 days of gestation (DG), the decidua and metrial gland were collected for histomorphometric and immunohistochemical evaluation of the expression of VEGF, Flk-1 and Tie-2. (scielo.br)
  • Elevated level of free 8-iso-prostaglandin F2alpha in the decidua basalis of women with preeclampsia. (readabstracts.com)
  • Formation of a specialized decidua is called decidualization, which is a special property of endometrium seen only in hemochorial placentation. (bionity.com)
  • Three morphologically distinct layers of the decidua basalis can then be described: Compact outer layer (stratum compactum) Intermediate layer (stratum spongiosum) Boundary layer adjacent to the myometrium (stratum basalis) Within the decidua, occasional fibrinoid deposits form where the syncytiotrophoblast is damaged. (wikipedia.org)
  • Here, we show that, during the first trimester of pregnancy, neutrophils infiltrate decidua basalis and are more abundant in normal pregnancy than in spontaneous miscarriages. (elsevier.com)
  • The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell. (umich.edu)
  • Test details of decidua and villi data. (bibf1120.com)
  • Results: LIF mRNA levels were not different either between different tissues (decidua vs chorionic villi) or between different patients (NP vs AP). (elsevier.com)
  • LIF-Rβ mRNA levels were significantly higher in chorionic villi than in decidua but were not different between NP and AP. (elsevier.com)
  • Conclusions: This study concluded that at early human post-implantation stage, LIF is produced from both decidua and chorionic villi and may exert its major action on trophoblasts. (elsevier.com)
  • With implantation the lining now termed decidua evolves further during the pregnancy. (bionity.com)
  • 1% of normal uNK cell frequency, no development of an implantation site-associated metrial gland, and an edematous decidua with vascular pathology that includes abnormally high vessel walls/lumens ratios. (rupress.org)
  • Farrar, JD & Carson, DD 1992, ' Differential temporal and spatial expression of mRNA encoding extracellular matrix components in decidua during the peri-implantation period ', Biology of Reproduction , vol. 46, no. 6, pp. 1095-1108. (elsevier.com)
  • A range of innate immune mechanisms can respond to pathogens in both the decidua and the placenta ( 3 , 4 ). (frontiersin.org)
  • This study aimed to evaluate the effects of thyroid hormone on the decidua and metrial gland of rats and to examine the expression of angiogenic factors. (scielo.br)
  • However, at 10 DG, excess T 4 resulted in increased of Flk-1 in the decidua and metrial gland. (scielo.br)
  • Hypothyroidism increased the Tie-2 at 10 and 19 DG in the decidua and metrial gland. (scielo.br)
  • While the exact pathogenesis of placenta creta is unknown, proposed hypotheses include a primary deficiency of decidua, abnormal maternal vascular remodeling, excessive trophoblastic invasion, or a combination thereof. (semanticscholar.org)
  • Compositional studies: antioxidant and antidiabetic activities of Capparis decidua (Forsk. (ac.ir)
  • Austgulen, R. STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women. (ntnu.no)