Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.
The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
The abrupt and unexplained death of an apparently healthy infant under one year of age, remaining unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of the clinical history. (Pediatr Pathol 1991 Sep-Oct;11(5):677-84)
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
The hollow, muscular organ that maintains the circulation of the blood.
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.
Cardiac electrical stimulators that apply brief high-voltage electroshocks to the HEART. These stimulators are used to restore normal rhythm and contractile function in hearts of patients who are experiencing VENTRICULAR FIBRILLATION or ventricular tachycardia (TACHYCARDIA, VENTRICULAR) that is not accompanied by a palpable PULSE. Some defibrillators may also be used to correct certain noncritical dysrhythmias (called synchronized defibrillation or CARDIOVERSION), using relatively low-level discharges synchronized to the patient's ECG waveform. (UMDNS, 2003)
Pathological conditions involving the HEART including its structural and functional abnormalities.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
An electrical current applied to the HEART to terminate a disturbance of its rhythm, ARRHYTHMIAS, CARDIAC. (Stedman, 25th ed)
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Surgery performed on the heart.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
Elements of limited time intervals, contributing to particular results or situations.
The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Postmortem examination of the body.
A voltage-gated sodium channel subtype that mediates the sodium ion PERMEABILITY of CARDIOMYOCYTES. Defects in the SCN5A gene, which codes for the alpha subunit of this sodium channel, are associated with a variety of CARDIAC DISEASES that result from loss of sodium channel function.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)
A congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the RIGHT VENTRICLE wall and loss of myocardial cells. Primary injuries usually are at the free wall of right ventricular and right atria resulting in ventricular and supraventricular arrhythmias.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The study of the electrical activity and characteristics of the HEART; MYOCARDIUM; and CARDIOMYOCYTES.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
A form of long QT syndrome that is without congenital deafness. It is caused by mutation of the KCNQ1 gene which encodes a protein in the VOLTAGE-GATED POTASSIUM CHANNEL.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
A voltage-gated potassium channel that is expressed primarily in the HEART.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Methods to induce and measure electrical activities at specific sites in the heart to diagnose and treat problems with the heart's electrical system.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
Malformations of CORONARY VESSELS, either arteries or veins. Included are anomalous origins of coronary arteries; ARTERIOVENOUS FISTULA; CORONARY ANEURYSM; MYOCARDIAL BRIDGING; and others.
Contractile activity of the MYOCARDIUM.
A family of voltage-gated potassium channels that are characterized by long N-terminal and C-terminal intracellular tails. They are named from the Drosophila protein whose mutation causes abnormal leg shaking under ether anesthesia. Their activation kinetics are dependent on extracellular MAGNESIUM and PROTON concentration.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
The application of pathology to questions of law.
An autosomal dominant inherited form of HYPERTROPHIC CARDIOMYOPATHY. It results from any of more than 50 mutations involving genes encoding contractile proteins such as VENTRICULAR MYOSINS; cardiac TROPONIN T; ALPHA-TROPOMYOSIN.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Compression of the heart by accumulated fluid (PERICARDIAL EFFUSION) or blood (HEMOPERICARDIUM) in the PERICARDIUM surrounding the heart. The affected cardiac functions and CARDIAC OUTPUT can range from minimal to total hemodynamic collapse.
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
Activities or games, usually involving physical effort or skill. Reasons for engagement in sports include pleasure, competition, and/or financial reward.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
An alkaloid found in the root of RAUWOLFIA SERPENTINA, among other plant sources. It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials.
Individuals who have developed skills, physical stamina and strength or participants in SPORTS or other physical activities.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BUNDLE OF HIS thus preventing the simultaneous depolarization of the two ventricles.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Services specifically designed, staffed, and equipped for the emergency care of patients.
The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A characteristic symptom complex.
The transference of a heart from one human or animal to another.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
Hospitals controlled by agencies and departments of the state government.
A form of long QT syndrome that is associated with congenital deafness. It is characterized by abnormal cardioelectrophysiology involving the VOLTAGE-GATED POTASSIUM CHANNEL. It results from mutation of KCNQ1 gene (Subtype 1 or JLN1) or the KCNE1 gene (Subtype 2 or JLN2).
A variety of neuromuscular conditions resulting from MUTATIONS in ION CHANNELS manifesting as episodes of EPILEPSY; HEADACHE DISORDERS; and DYSKINESIAS.
A condition in which HEART VENTRICLES exhibit impaired function.
A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).
A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.
Examinations used to diagnose and treat heart conditions.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Precursor cells destined to differentiate into cardiac myocytes (MYOCYTES, CARDIAC).
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.
A malformation that is characterized by a muscle bridge over a segment of the CORONARY ARTERIES. Systolic contractions of the muscle bridge can lead to narrowing of coronary artery; coronary compression; MYOCARDIAL ISCHEMIA; MYOCARDIAL INFARCTION; and SUDDEN CARDIAC DEATH.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Myosin type II isoforms found in cardiac muscle.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
General or unspecified injuries to the chest area.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
Factors associated with the definitive onset of a disease, illness, accident, behavioral response, or course of action. Usually one factor is more important or more obviously recognizable than others, if several are involved, and one may often be regarded as "necessary". Examples include exposure to specific disease; amount or level of an infectious organism, drug, or noxious agent, etc.
An infant during the first month after birth.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
Visualization of the heart structure and cardiac blood flow for diagnostic evaluation or to guide cardiac procedures via techniques including ENDOSCOPY (cardiac endoscopy, sometimes refered to as cardioscopy), RADIONUCLIDE IMAGING; MAGNETIC RESONANCE IMAGING; TOMOGRAPHY; or ULTRASONOGRAPHY.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect.
Specific practices for the prevention of disease or mental disorders in susceptible individuals or populations. These include HEALTH PROMOTION, including mental health; protective procedures, such as COMMUNICABLE DISEASE CONTROL; and monitoring and regulation of ENVIRONMENTAL POLLUTANTS. Primary prevention is to be distinguished from SECONDARY PREVENTION and TERTIARY PREVENTION.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Potassium channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. The opening of these channels is induced by the membrane depolarization of the ACTION POTENTIAL.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
The veins and arteries of the HEART.
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.
Conceptual response of the person to the various aspects of death, which are based on individual psychosocial and cultural experience.
The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.
The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute, and QRS complexes with changing amplitude and twisting of the points. The term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long QT intervals exceeding 500 milliseconds or BRADYCARDIA. Torsades de pointes may be self-limited or may progress to VENTRICULAR FIBRILLATION.
The chambers of the heart, to which the BLOOD returns from the circulation.
A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.
Acidic protein found in SARCOPLASMIC RETICULUM that binds calcium to the extent of 700-900 nmoles/mg. It plays the role of sequestering calcium transported to the interior of the intracellular vesicle.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
Methods and procedures for the diagnosis of diseases or dysfunction of the cardiovascular system or its organs or demonstration of their physiological processes.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed)
Transmission of the readings of instruments to a remote location by means of wires, radio waves, or other means. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The hemodynamic and electrophysiological action of the HEART VENTRICLES.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.
This structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES.
A group of conditions in which HEART VENTRICLE activation by the atrial impulse is faster than the normal impulse conduction from the SINOATRIAL NODE. In these pre-excitation syndromes, atrial impulses often bypass the ATRIOVENTRICULAR NODE delay and travel via ACCESSORY CONDUCTING PATHWAYS connecting the atrium directly to the BUNDLE OF HIS.
All deaths reported in a given population.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
The field of medicine concerned with physical fitness and the diagnosis and treatment of injuries sustained in exercise and sports activities.
A paravertebral sympathetic ganglion formed by the fusion of the inferior cervical and first thoracic ganglia.
The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.
A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.
Institutions specializing in the care of patients with heart disorders.
The posture of an individual lying face down.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
The return of a sign, symptom, or disease after a remission.
Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.

Respiratory symptoms and long-term risk of death from cardiovascular disease, cancer and other causes in Swedish men. (1/2144)

BACKGROUND: Depressed respiratory function and respiratory symptoms are associated with impaired survival. The present study was undertaken to assess the relation between respiratory symptoms and mortality from cardiovascular causes, cancer and all causes in a large population of middle-aged men. METHODS: Prospective population study of 6442 men aged 51-59 at baseline, free of clinical angina pectoris and prior myocardial infarction. RESULTS: During 16 years there were 1804 deaths (786 from cardiovascular disease, 608 from cancer, 103 from pulmonary disease and 307 from any other cause). Men with effort-related breathlessness had increased risk of dying from all of the examined diseases. After adjustment for age, smoking habit and other risk factors, the relative risk (RR) associated with breathlessness of dying from coronary disease was 1.43 (95% CI : 1.16-1.77), from stroke 1.77 (95% CI: 1.07-2.93), from any cardiovascular disease 1.48 (95% CI : 1.24-1.76), cancer 1.36 (95% CI : 1.11-1.67) and from any cause 1.62 (95% CI: 1.44-1.81). An independent effect of breathlessness on cardiovascular death, cancer death and mortality from all causes was found in life-time non-smokers, and also if men with chest pain not considered to be angina were excluded. An independent effect was also found if all deaths during the first half of the follow-up were excluded. Men with cough and phlegm, without breathlessness, also had an elevated risk of dying from cardiovascular disease and cancer, but after adjustment for smoking and other risk factors this was no longer significant. However, a slightly elevated independent risk of dying from any cause was found (RR = 1.18 [95% CI: 1.02-1.36]). CONCLUSION: A positive response to a simple question about effort related breathlessness predicted subsequent mortality from several causes during a follow-up period of 16 years, independently of smoking and other risk factors.  (+info)

Molecular heterogeneity in very-long-chain acyl-CoA dehydrogenase deficiency causing pediatric cardiomyopathy and sudden death. (2/2144)

BACKGROUND: Genetic defects are being increasingly recognized in the etiology of primary cardiomyopathy (CM). Very-long-chain acyl-CoA dehydrogenase (VLCAD) catalyzes the first step in the beta-oxidation spiral of fatty acid metabolism, the crucial pathway for cardiac energy production. METHODS AND RESULTS: We studied 37 patients with CM, nonketotic hypoglycemia and hepatic dysfunction, skeletal myopathy, or sudden death in infancy with hepatic steatosis, features suggestive of fatty acid oxidation disorders. Single-stranded conformational variance was used to screen genomic DNA. DNA sequencing and mutational analysis revealed 21 different mutations on the VLCAD gene in 18 patients. Of the mutations, 80% were associated with CM. Severe CM in infancy was recognized in most patients (67%) at presentation. Hepatic dysfunction was common (33%). RNA blot analysis and VLCAD enzyme assays showed a severe reduction in VLCAD mRNA in patients with frame-shift or splice-site mutations and absent or severe reduction in enzyme activity in all. CONCLUSIONS: Infantile CM is the most common clinical phenotype of VLCAD deficiency. Mutations in the human VLCAD gene are heterogeneous. Although mortality at presentation is high, both the metabolic disorder and cardiomyopathy are reversible.  (+info)

Sudden death in hypertrophic cardiomyopathy: potential importance of altered autonomic control of vasculature. (3/2144)

Current evidence suggests that alterations in the autonomic function and abnormal vascular control play a significant role either as independent triggers themselves or as modifiers of ischaemia and tolerance to to arrhythmias. A combination of several factors--that is, arrhythmia, hypotension, altered autonomic function including vascular control, and ischaemia are therefore likely to act as triggers for sudden death. The relative contribution of each of these factors needs further detailed study.  (+info)

Effect of angiotensin converting enzyme inhibition on sudden cardiac death in patients following acute myocardial infarction. A meta-analysis of randomized clinical trials. (4/2144)

Estimate the effect of angiotensin converting enzyme (ACE) inhibitors on the risk of sudden cardiac death (SCD) following myocardial infarction (MI). BACKGROUND: Trials in post-MI patients have shown that ACE inhibitor therapy reduces mortality. However, the effect on SCD as a mechanism has not been clarified. METHODS: Trials of ACE inhibitor therapy following MI reported between January, 1978 and August, 1997 were identified. Studies were included if they met the following criteria: 1) randomized comparison of ACE inhibitor to placebo within 14 days of MI; 2) study duration/blinded follow-up of > or =6 weeks; 3) the number of deaths and modes of death were reported or could be obtained from the investigators. RESULTS: We identified 374 candidate articles, of which 15 met the inclusion criteria. The 15 trials included 15,104 patients, 2,356 of whom died. Most (87%) fatalities were cardiovascular and 900 were SCDs. A significant reduction in SCD risk or a trend towards this was observed in all of the larger (N > 500) trials. Overall, ACE inhibitor therapy resulted in significant reductions in risk of death (random effects odds ratio [OR] = 0.83; 95% confidence interval [CI] 0.71-0.97), cardiovascular death (OR = 0.82; 95% CI 0.69-0.97) and SCD (OR = 0.80; 95% CI 0.70-0.92). CONCLUSIONS: This analysis is consistent with prior reports showing that ACE inhibitors decrease the risk of death following a recent MI by reducing cardiovascular mortality. Moreover, this analysis suggests that a reduction in SCD risk with ACE inhibitors is an important component of this survival benefit.  (+info)

Detection of abnormal high-frequency components in the QRS complex by the wavelet transform in patients with idiopathic dilated cardiomyopathy. (5/2144)

In order to investigate whether increased fine, fractionated signals within the QRS complex can detect arrhythmogenic substrates and how these fine signals link with ventricular mechanical dysfunction, wavelet analysis was performed on averaged QRS complexes obtained from the left precordial lead in 26 patients with idiopatic dilated cardiomyopathy (IDCM) and in 12 normal subjects. The number of local maxima and the duration of the wavelet transform were significantly greater in patients with IDCM than in normal subjects; the number at 100 Hz was 8.8+/-3.1 vs 6.0+/-1.1 (p<0.01), and the duration at 100Hz was 93+/-15 vs 75+/-7ms (p<0.01). Both of these indices were greater in the patients with than in those without late potentials, repetitive ventricular premature beats or cardiac death. In addition, significant inverse curvilinear relationships were observed between the left ventricular ejection fraction and both the number of local maxima and the duration of the wavelet transform. In conclusion, fine fragmented signals in the QRS complex detected by wavelet analysis would be an important marker for potentially arrhythmogenic substrates and seemed to progress in parallel with left ventricular mechanical dysfunction in IDCM.  (+info)

Sudden death in the general population in Okinawa: incidence and causes of death. (6/2144)

Sudden unexpected death is generally considered to be caused by acute myocardial infarction and/or arrhythmia. To document the incidence and causes of sudden death in Japan, where the incidence of myocardial infarction is low, the present study examined death certificates, hospital records, the forensic medical records, and the police records of residents of the southern part of Okinawa island who died at the age of 20-74 years during a 3-year period from January 1, 1992 to December 31, 1994. Sudden death was defined as death within 24 h from the onset of unexpected symptoms. The study documented 126 (87 men and 39 women) sudden deaths. The crude incidence rate was 0.37/1,000 person per year (0.51 in men and 0.23 in women). According to the death certificates, 78 cases died of heart diseases. However, the cause of death could be determined by examination of all available records in only 64 cases: myocardial infarction in 10, non-ischemic heart diseases in 13, and stroke in 23 cases. Even when the analysis was limited to the cases who died within 1 h from the onset of symptoms, heart disease was the cause of death in only 22% of the cases while the cause of death could not be determined in 53% of the cases. Only 13% of those diagnosed as heart diseases on the death certificate were verified. The agreement rate between the diagnosis reached by the re-evaluation of the records and that on the death certificate was 82% for stroke and 33% for other diseases. In Okinawa, Japan, the frequencies of heart disease and stroke as the cause of sudden death may be similar. Except for stroke, the diagnosis appearing on the death certificate has substantial inaccuracy.  (+info)

Mechanisms of death in the CABG Patch trial: a randomized trial of implantable cardiac defibrillator prophylaxis in patients at high risk of death after coronary artery bypass graft surgery. (7/2144)

BACKGROUND: The CABG Patch trial compared prophylactic implantable cardiac-defibrillator (ICD) implantation with no antiarrhythmic therapy in coronary bypass surgery patients who had a left ventricular ejection fraction <0.36 and an abnormal signal-averaged ECG. There were 102 deaths among the 446 ICD group patients and 96 deaths among the 454 control group patients, a hazard ratio of 1.07 (P=0.63). The mechanisms of death were classified, and hypotheses were tested about the effects of ICD therapy on arrhythmic and nonarrhythmic cardiac deaths in the CABG Patch Trial and the Multicenter Automatic Defibrillator Implantation Trial (MADIT). METHODS AND RESULTS: The 198 deaths in the trial were reviewed by an independent Events Committee and classified by the method of Hinkle and Thaler. Only 54 deaths (27%) occurred out of hospital; 145 deaths (73%) were witnessed. Seventy-nine (82%) of the 96 deaths in the control group and 76 (75%) of the 102 deaths in the ICD group were due to cardiac causes. Cumulative arrhythmic mortality at 42 months was 6.9% in the control group and 4.0% in the ICD group (P=0. 057). Cumulative nonarrhythmic cardiac mortality at 42 months was 12. 4% in the control group and 13.0% in the ICD group (P=0.275). Death due to pump failure was significantly associated with death >1 hour from the onset of symptoms, dyspnea within 7 days of death, and overt heart failure within 7 days of death. CONCLUSIONS: In the CABG Patch Trial, ICD therapy reduced arrhythmic death 45% without significant effect on nonarrhythmic deaths. Because 71% of the deaths were nonarrhythmic, total mortality was not significantly reduced.  (+info)

Drug-induced heart failure. (8/2144)

Heart failure is a clinical syndrome that is predominantly caused by cardiovascular disorders such as coronary heart disease and hypertension. However, several classes of drugs may induce heart failure in patients without concurrent cardiovascular disease or may precipitate the occurrence of heart failure in patients with preexisting left ventricular impairment. We reviewed the literature on drug-induced heart failure, using the MEDLINE database and lateral references. Successively, we discuss the potential role in the occurrence of heart failure of cytostatics, immunomodulating drugs, antidepressants, calcium channel blocking agents, nonsteroidal anti-inflammatory drugs, antiarrhythmics, beta-adrenoceptor blocking agents, anesthetics and some miscellaneous agents. Drug-induced heart failure may play a role in only a minority of the patients presenting with heart failure. Nevertheless, drug-induced heart failure should be regarded as a potentially preventable cause of heart failure, although sometimes other priorities do not offer therapeutic alternatives (e.g., anthracycline-induced cardiomyopathy). The awareness of clinicians of potential adverse effects on cardiac performance by several classes of drugs, particularly in patients with preexisting ventricular dysfunction, may contribute to timely diagnosis and prevention of drug-induced heart failure.  (+info)

Causes of Sads - Sudden arrhythmic death syndrome - conditions responsible for SADS cause a cardiac arrest by bringing on a disturbance in the hearts rhythm, even though there is no structural heart disease
SADS UK - Preventing loss of life from Sudden Arrhythmic Death Syndrome (SADS) and highlighting cardiac risk in the young through to middle age.
The articles are based on the findings of a large, well-conducted case-control study from the Netherlands (8). This compared 775 cases of sudden cardiac death with 6,297 matched controls, with respect to the use of seven drugs (two antibiotics, two stomach and three antipsychotic medications). This found a significantly increased risk of sudden cardiac death for current users (by three times), particularly those with less than 90 days use (by four times) compared with non-users. * Most newspapers reported the research fairly accurately but three (1,6,7) incorrectly stated that the drugs were responsible for 320 of the 775 sudden cardiac deaths in the study, when the authors report that they may be linked to 320 cases per year in the Netherlands, based on the rate of sudden cardiac death in the study. They all reported that the researchers state that patients taking these drugs should not stop taking them without consulting their GP. Evaluation of the evidence base for the association between the ...
BACKGROUND--Although heart rate variability has already been studied in survivors of sudden cardiac death secondary to coronary artery disease, an assessment of heart rate variability in survivors of sudden cardiac death not associated with coronary artery disease has not been made. METHODS--10 patients with aborted sudden cardiac death not associated with coronary artery disease (seven patients with primary ventricular fibrillation and three with unclassified mild cardiomyopathy) underwent two channel 24 hour Holter monitoring in a drug free state. All subjects were in sinus rhythm and had normal atrioventricular conduction and normal cardiac function. Spectral heart rate variability was analysed on a Holter analysis system and was expressed as total (0.01-1.00 Hz), low (0.04-0.15 Hz) and high (0.15-0.40 Hz) frequency components for each hour. Heart rate variability index was calculated for the 24 hour periods. 10 age and sex matched healthy subjects were taken as a control group. RESULTS--The ...
TY - JOUR. T1 - The association between atrial fibrillation and sudden cardiac death. T2 - The relevance of heart failure. AU - Reinier, Kyndaron. AU - Marijon, Eloi. AU - Uy-Evanado, Audrey. AU - Teodorescu, Carmen. AU - Narayanan, Kumar. AU - Chugh, Harpriya. AU - Gunson, Karen. AU - Jui, Jonathan. AU - Chugh, Sumeet S.. PY - 2014. Y1 - 2014. N2 - Objectives: The purpose of this study was to evaluate the role of congestive heart failure (CHF) in the association between atrial fibrillation (AF) and sudden cardiac death (SCD). Background: Recent studies have reported the possibility of an independent association between AF and SCD. We hypothesized that a history of CHF is a significant confounder of this association. Methods: In a prospective case-control analysis from the community (The Oregon-SUDS [Sudden Unexpected Death Study], 2002 to 2012), SCD cases (n = 652) with clinical records available (including electrocardiography and/or echocardiography) were compared with age- and sex-matched ...
Sudden cardiac death can occur when someone in sudden cardiac arrest is not treated promptly. Sudden cardiac arrest occurs when the hearts electrical system malfunctions and the heart suddenly stops beating ? often without warning. While the terms sudden cardiac arrest and heart attack are often used as if they are synonyms, they arent. Sudden cardiac arrest can occur after a heart attack, or during recovery. Heart attacks increase the risk for sudden cardiac arrest, but most heart attacks do not lead to sudden cardiac arrest. Immediate CPR can double or triple the chances of survival from sudden cardiac arrest. ...
We assessed risk factors for sudden coronary death among persons without a history of coronary heart disease (unexpected sudden coronary death) and persons with a history of coronary heart disease (sudden coronary heart disease death). We analyzed national data to calculate death rates and odds rati …
Title: Regulation of Cardiac Nerves: A New Paradigm in The Management of Sudden Cardiac Death?. VOLUME: 15 ISSUE: 17. Author(s):Masaki Ieda, Kensuke Kimura, Hideaki Kanazawa and Keiichi Fukuda. Affiliation:Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi,Shinjuku-ku, Tokyo 160-8582, Japan.. Keywords:Heart, cardiac nerve, nerve growth factor, Sema3a, arrhythmia, sudden cardiac death. Abstract: The heart is extensively innervated, and its performance is tightly regulated by the autonomic nervous system. To maintain cardiac function, innervation density is stringently controlled, being high in the subepicardium and the central conduction system. In diseased hearts, cardiac innervation density varies, which in turn leads to sudden cardiac death. After myocardial infarction, sympathetic denervation is followed by reinnervation within the heart, leading to unbalanced neural activation and lethal arrhythmia. Diabetic sensory ...
Research Paper Title Sudden Cardiac Death in Athletes. Abstract Sudden cardiac death is defined as an unexpected death, occurring usually within one hour from onset of symptoms in cases where the death is witnessed and in unwitnessed cases within 24 hours of the individual last being seen alive and well. Sudden cardiac death in athletes is the leading…
Heart structural gene causes sudden cardiac death in animal model The presence or absence of the CAP2 gene causes sudden cardiac death in mice. In particular, the absence of the gene interrupts the animals ability to send electrical signals to the heart to tell it to contract, a condition called cardiac conduction disease. Since humans have the same CAP2 gene, what we learn from the mice could advance our understanding of heart disease. ...
The Royal College of Pathologists have published guidelines on autopsy practice as a new set of standardised best practice scenarios. Scenario 1 (sudden death with likely cardiac pathology) was issued in 2005.1 The intention of the College Working Party on the Autopsy was that the scenarios would be periodically reviewed, updated and augmented.2 There is a need to place cannabis, nicotine, non-steroidal anti-inflammatory drugs (NSAIDs) and psychology in the proper context when reporting on cardiac deaths. The rationale follows.. In the list of drugs, both licit and illicit, which may cause sudden cardiac death is marijuana. The sentinel paper on cannabis as a trigger for sudden cardiac death is a case crossover study from Mittleman et al, which reported that the elevated risk of triggering myocardial infarction is limited to about the first 2 h after smoking cannabis.3 The RR of infarction was increased by 3.2 in the first hour if confounders were excluded. In the second hour, the RR was 1.7. ...
Sudden cardiac death, which occurs when the heart unexpectedly stops, was second only to AIDS as a leading cause of death among HIV patients in a new ...
Sudden cardiac death (SCD) poses a significant health care challenge with high annual incidence and low survival rates. Implantable cardioverter defibrillators (ICDs) prevent SCD in patients with left ventricular (LV) systolic dysfunction. However, the critical survival benefit afforded by the devices is accompanied by short and long-term complications and a high economic burden. Moreover, in using current practice guidelines of LV ejection fraction (LVEF)≤35% as the main determining factor for patient selection, only a minority of patients actually benefit from ICD therapy (,25% in 5 years). There is an essential need for more robust diagnostic approaches to SCD risk stratification.. This project examines the hypothesis that LV structural abnormalities above and beyond global LV dysfunction are important predictors of SCD risk since they indicate the presence of abnormal pathophysiologic substrate required for the ventricular arrhythmogenicity leading to SCD. This premise is supported by ...
Survival rates of out-of-hospital sudden cardiac arrest doubled with the use of a new resuscitation protocol, reports a study in the May 19 issue of Circulation. Despite resuscitation efforts by emergency medical services (EMS), as many as 450,000 people die of sudden cardiac arrest each year in the United States. The new protocol instructs EMS personnel to raise the compression-to-ventilation ratio from the previously recommended 5:1 to 50:2 and to delay intubation, thereby increasing spontaneous circulation. The survival rate increased from 22% under the old resuscitation method to 44% with the new protocol. Moreover, most patients had a good neurologic outcome. ...
Being overweight or obese throughout adulthood, especially during early adulthood, may lead to an increased risk of sudden cardiac death, according to a study published Nov. 25 in JACC: Clinical Electrophysiology.. Researchers led by Stephanie Chiuve, ScD, an assistant professor of medicine at Harvard Medical School, analyzed data from the Nurses Health study, following 72,484 healthy women from 1980 to 2012. Over the study period, researchers documented 445 cases of sudden cardiac death, 1,286 cases of fatal coronary heart disease, and 2,272 non-fatal myocardial infarction (MI). Results showed women who were overweight (body mass index [BMI] 25-30) and obese (BMI 30 or greater) were 1.5- and 2-times more likely, respectively, to experience sudden cardiac death over the next two years as compared to women with a healthy weight (BMI 21-23).. Further, women who were overweight or obese at the start of the study or obese at age 18 had an elevated risk of sudden cardiac death over the entire course ...
HearTwave II Microvolt T-Wave Alternans System With Analytic Spectral Method,The HearTwave II system is the Cambridge Heart next generation Microvolt T-Wave Alternans (MTWA) testing platform which simplifies hospital and office-based sudden cardiac death risk stratification. This new system offers expanded versatility as it can be configured to perform MTWA and/or standard,medicine,medical supply,medical supplies,medical product
A leading cause of death in western countries is sudden cardiac death, and can be associated with genetic disease. Next-generation sequencing has allowed thorough analysis of genes associated with this entity, including, most recently, titin. We aimed to identify potentially pathogenic genetic variants in titin. A total of 1126 samples were analyzed using a custom sequencing panel including major genes related to sudden cardiac death. Our cohort was divided into three groups: 432 cases from patients with cardiomyopathies, 130 cases from patients with channelopathies, and 564 post-mortem samples from individuals showing anatomical healthy hearts and non-conclusive causes of death after comprehensive autopsy. None of the patients included had definite pathogenic variants in the genes analyzed by our custom cardio-panel. Retrospective analysis comparing the in-house database and available public databases also was performed. We identified 554 rare variants in titin, 282 of which were novel. Seven were
The ALLMedicine™ Sudden Cardiac Death Center contains research, news, guidelines, drugs, clinical trials, and patient ed. Information related to Sudden Cardiac Death. Browse Now!
Worldwide leaders in cardiopulmonary and metabolic diagnostics, including spirometry, pulmonary function, indirect calorimetry, exercise testing, body composition.
Physically and psychologically stressful law enforcement duties are associated with large increases in the risk of sudden cardiac death compared with routine/non-emergency policing activities. To our knowledge our study is the first to show an association between specific law enforcement duties and risk of sudden cardiac death-a finding that supports the hypothesis that stressful work related activities can trigger sudden cardiac death and is consistent with our previous studies of on duty acute cardiac deaths among firefighters.14 15 16 In addition, our finding that up to 10% of all on duty deaths during law enforcement are sudden cardiac deaths represents the most accurate estimate to date of the proportionate mortality from sudden cardiac death in this population.. While routine/non-emergency duties constituted about 75% of police work time, 77% of sudden cardiac deaths occurred during non-routine tasks. Physical restraints and altercations comprised about 1-2% of a police officers annual ...
When the heart experiences a disturbance that disrupts its pumping action it ceases blood flow to the rest of the body, which triggers a sudden, unexpected loss of heart function, breathing, and consciousness. This is known as sudden cardiac arrest.. Sudden cardiac arrest differs from a heart attack. Heart attacks occur when blood flow to a portion of the heart is blocked. However, heart attacks can spur a disturbance that leads to sudden cardiac arrest. Sudden cardiac arrest is a dire situation and requires immediate attention. Fast, appropriate care increases survival odds. With it being Sudden Cardiac Arrest Awareness Month, lets delve into what that fast, appropriate care looks like and how to recognize if someone is experiencing this traumatic event.. Symptoms are drastic and immediate. Someone experiencing sudden cardiac arrest collapses, loses a pulse, stops breathing, and is unconscious. Occasionally there are visible symptoms that precede sudden cardiac arrest, such as: fatigue, ...
Bridget McAnallen was speaking at the publication of a report on sudden cardiac death which coincided with the second anniversary of her sons death. She said screening of young people participating in sport was essential as it could alert them of the need to alter or regulate their lifestyle.. However, a special task force on sudden cardiac death has advised the Government that there is insufficient evidence to support the introduction of a mass population screening programme. It is estimated that 5,000 Irish people die from sudden cardiac death each year, including 60 people under the age of 40.. The task force was established in 2004 following public concern about the death of several high-profile young sports stars including Cormac McAnallen. However, the task force claimed that mass population screening programmes could lead to large numbers of normal young people being needlessly excluded from participating in sport and physical activity.. Chairman of the task force, Dr Brian Maurer of the ...
Sudden cardiac arrest is not a heart attack (myocardial infarction). Learn more about sudden cardiac death, symptoms, causes, risk factors, treatment and prevention measures - Cleveland Clinics Heart and Vascular Institute specializes in heart care for patients facing all manner of valvular and vascular heart issues as well as other heart disorders.
For general clinical purposes, the term sudden cardiac death is usually reserved for those deaths in which the patient had stable cardiac function until the terminal event, with death occurring within a short time (often defined as less than 1 hour) of the onset of symptoms. Some experts prefer the term instantaneous death, namely, death with immediate collapse without preceding symptoms. Instantaneous death is usually assumed to be due to a primary arrhythmia, but other catastrophic events, such as a massive pulmonary embolism, the rupture of an aortic aneurysm, or a stroke, can also cause instantaneous death. It is also important to note that not all arrhythmic deaths are sudden. For example, a patient who is resuscitated from a cardiac arrest may die days or weeks later from complications of the arrest. This death would be due to an arrhythmia but would not meet the standard time-based definition for instantaneous or sudden death. ...
Serious ventricular arrhythmias account for the majority of sudden cardiac death after acute myocardial infarction (MI), and identification and treatment of patients at risk of sudden cardiac death remains a major focus of clinical practice (4). Implantable cardioverter defibrillators (ICD) have been the mainstay of therapy for this condition and are currently indicated in patients with reduced cardiac systolic function, based on a left ventricular ejection fraction (LVEF) ,35%. Although ICD is effective in reducing the occurrence of sudden cardiac death the device never delivers therapy in a large proportion of recipients of an ICD based on reduced LVEF. Also, the majority of patients who die suddenly would not have qualified for ICD under current LVEF-based guidelines (5).. While a depressed LVEF portends a poor outcome, the accuracy of prediction of sudden cardiac death with LVEF alone is moderate to low. In the post-infarct setting, several studies have additionally focused on the electrical ...
Introduction: Association between early repolarization (ER) on ECG and sudden cardiac arrest (SCA) risk has been suggested by epidemiologic studies with variable prognostic results. This association has not been investigated in autopsy-proven sudden cardiac deaths (SCDs).. Methods: All pre-arrest ECGs performed as part of medical care were obtained and reviewed for ER on all resuscitated SCAs and all out-of-hospital (OOH) SCDs in San Francisco (SF) between 2/1/2011 and 3/1/2014 captured through active surveillance of all deaths reported to the Office of the Chief Medical Examiner as part of the SF Postmortem Systematic Investigation of Sudden Cardiac Death (POST SCD) study. All contemporaneous citywide resuscitated SCAs were identified via responding SF Fire Department paramedic records and cause of death was adjudicated after review of autopsy, toxicology, histology, and medical records. ER was defined as elevation of QRS-ST junction ≥ 0.1mV in ≥ 2 contiguous inferior or lateral leads, ...
Sudden cardiac death (SCD) is an important public-health problem with multiple etiologies, risk factors, and changing temporal trends. Substantial progress has been made over the past few decades in identifying markers that confer increased SCD risk at the population level. However, the quest for pr …
Some[who?] say that the Hmong who died were killed by their own beliefs in the spiritual world, otherwise known as, Nocturnal Pressing Spirit Attacks. In Indonesia it is called digeuton, which translates to pressed on in English.[8] In China it is called bèi guǐ yā (traditional Chinese: 被鬼壓; simplified Chinese: 被鬼压) which translates to crushed by a ghost in English.[8] The Dutch call the presence a nachtmerrie, the night-mare.[8] The merrie comes from the Middle Dutch mare, an incubus who lies on peoples chests, suffocating them. This phenomenon is well known among the Hmong people of Laos,[16] who ascribe these deaths to a malign spirit, dab tsuam (pronounced da cho), said to take the form of a jealous woman. Hmong men may even go to sleep dressed as women so as to avoid the attentions of this spirit.[citation needed]. During the 1970s and 1980s, when an outbreak of this syndrome began, many of the Southeast Asians were not able to worship properly due to the ...
Studies of some children with a rare developmental problem, called 6p22 syndrome, hint that this gene is associated with similar cardiac issues in people. These children have deep-set eyes and cardiac problems that are not well defined. Almost all of these children are born with a deletion of one of their copies of the CAP2 gene, Field noted.. Knowing this connection, the researchers generated mice that would exhibit only cardiac conduction disease (CCD). They reinstated the gene but this time engineered it so they could knock it out again, but this time only in the hearts of the mice. It took close to five years to perfect this mouse model that exhibited only the heart knockout, Field said. The researchers could then conduct experiments targeting only the heart problem, because all the other symptoms, such as the eye problems, were out of the picture.. The mice once again developed CCD, leading to sudden cardiac death from complete heart block, but there was an extra surprise this time. The ...
Research has suggested that heart and kidney disease play greater roles as risk factors for sudden cardiac death in patients with diabetes. Originally, diabetic autonomic neuropathy was always believed the main risk factor. The study involved 462 patients with diabetes who were followed for 15 years. Of the patients, the researchers documented 21 cases of sudden cardiac death. Reporting in the Journal of Neurology, Neurosurgery, and Psychiatry (February 2005), the researchers found that heart disease, including plaques in the blood vessels feeding the heart and heart attacks, was the biggest risk for sudden cardiac death. The researchers noted that all of the participants who died had some amount of plaque buildup. Kidney disease was also found as a key risk factor for the sudden cardiac death. ...
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Suzanne Lowrys son, Max, died suddenly on the eve of his wedding. A year on, his mother shares her sense of loss - and her hope that others may be spared the same fate
Cambridge Heart develops and commercializes non-invasive diagnostic tests for cardiac disease, with a focus on identifying those at risk for sudden cardiac arrest (SCA). The Company?s products incorporate proprietary Microvolt T-Wave Alternans measurement technologies including the patented Analytic Spectral Method? and ultrasensitive disposable electrode sensors. Medicare reimburses the Analytic Spectral Method? under its National Coverage Policy. Cambridge Heart, founded in 1990, is based in Tewksbury, MA. The company?s Microvolt T-Wave Alternans? (MTWA) test, developed by Cambridge Heart (OTCBB: CAMH), is based on research originally conducted at the Massachusetts Institute of Technology. http://www.cambridgeheart.com,http://www.cambridgeheart.com/, .. Statements contained in this press release are forward-looking statements for purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. In some cases, we use words such as ?believes?, ?expects?, ...
Cardiologist Dr Christian Wolpert, from the University Hospital Mannheim, Germany, (along with Drs Auricchio and Vardas) has researched the current status of cardiac electrophysiology in member countries of the European Society of Cardiology (ESC).. Overall in the emerging economies of ESC member countries, says Dr Wolpert, we have found great disparity in access to anti-arrhythmic therapy, for a variety of reasons. The implant rates and number of treating centres and physicians certainly correlate with the economic status of their countries and budget restrictions. However, even in countries with a higher GDP and where device therapy could be implemented, we have found low awareness, a lack of information and few treating specialist, all of which leads to severe under-treatment. A higher uptake of device therapy could save many sudden cardiac deaths.. An analysis of ICD use in ESC member countries (published by the EHRA in the 2010 White Book)(2) shows a great difference in the number of ...
Sudden cardiac death in young athletes is very rare. The estimated yearly rate varies from one country to another, however. In the United States, it i
Introduction: Sudden cardiac death in young adults is rare and since existing studies have few subjects, there is a lack of detailed information. We hypothesized that analysis from a large community-based investigation would provide novel mechanistic information.. Methods: In an ongoing, community-based study of prospectively-identified SCD cases in the Northwest US (2002 - 2011), cases aged 18 - 34 were compared with patients aged 35 - 59, and 60 or older. All cases were adjudicated by review of arrest circumstances and physician records. Cases with non-cardiac causes of SCD and terminal illnesses were excluded. Clinical history prior to arrest across the three age groups was compared using χ2 tests.. Results: Patients aged 18-34 (n=134, 59% male) made up 5% of the total 2740 cases ascertained, while patients aged 35-59 made up 36% (n=996, 75% male) and patients 60 or older made up 59% (n=1610, 62% male). Young patients were less likely to have physician records available for review (51% vs. ...
AD-arrhythmogenic dysplasia, N-normal, CMC-cardiomyocyte, DD-diastolic dysfunction, IC-inflammatory changes, LVOTO-left ventricular outflow tract obstruction, MF-myocardial fibrosis, SD-systolic dysfunction, VA-vagotonic adaptation, Myocardial fatigue refers to moderately expressed systolic and/or diastolic dysfunction. Sudden cardiac death associated with cardiac hypertrophy, exercises and other factors. Sports-related SCD is usually defined as sudden and unexpected death occurred during, or shortly after, exercise (with varying time intervals up to 24 hours) (13, 44, 45]. In fact, SCD is not a newly discovered condition in sports cardiology. Beside the creating a challenge for sports physicians and mass media, SCD influences the career of competitor and whole sports politics.. According to recent data, SCD incidence fluctuates from 0.75 in 100 000 to 1 in 40 000 and 1 in 80 000 athletic populations (46, 47]. It can be explained by variety of sports discipline, and overall health status of an ...
Sudden cardiac death (SCD) remains a major cause of mortality in the US. While the prophylactic implantable defibrillator has significantly reduced the incidenc...
Sudden cardiac death is the most common mode of death in this country with more than 300,000 deaths per year, a third of which occur during physical activity. It is estimated that approximately 1,000 children die of sudden death each year.
Aims: This study sought to confirm the efficacy of resting 12-lead ECG alongside personal symptom and family history questionnaire and physical examination when screening for diseases that have the potential of causing sudden cardiac death in the young. Methods and Results: One thousand and seventy four National and International junior athletes (15.8 ± 0.7 years, range 10-27) and 1646 physically active school children (16.1 ± 2.1 years, range 14-20) were screened using personal and family history questionnaires, physical examination and resting 12-Lead ECG. Nine participants with a positive diagnosis of a disease associated with sudden cardiac death were identified. None of the participants diagnosed with a disease associated with sudden cardiac death were symptomatic or had family history of note. Conclusion: Family history and personal symptom questionnaires alone are inadequate in the identification of individuals with diseases associated with sudden cardiac death. Utilisation of 12-lead ...
Urgency. Sudden cardiac death (SCD) still remains a leading cause of death in patients after MI. Because of the fluminant nature of SCD prediction of this event has acquired high priority. Aim. This study was focused on assessing the predictive significance of LV EF and other prognostic factors for SCD in patients after IM. Materials and methods. 420 patients after IM were evaluated; mean follow-up period was 2.6 years. Using multifactor regression analysis predictive effects of 194 factors on risk of SCD were evaluated. Results. Reduced LV EF was an important risk factor for SCD as it reflected not only the impaired LV contractility but also the arrhythmogenic substrate, processes of postinfarction remodeling and to a certain extent triggers of malignant arrhythmias. The LV EF predictive value increased when this parameter was used in combination with other echoCG parameters and also with such prognostic factors as ventricular arrhythmias, heart rhythm variability and data of an active ...
TY - JOUR. T1 - Genetic determinants of sudden cardiac death. AU - Noseworthy, Peter. AU - Newton-Cheh, Christopher. PY - 2008/10/28. Y1 - 2008/10/28. KW - Death, sudden. KW - Epidemiology. KW - Genetics. KW - Heart arrest. KW - Tachyarrhythmias. UR - http://www.scopus.com/inward/record.url?scp=56549109039&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=56549109039&partnerID=8YFLogxK. U2 - 10.1161/CIRCULATIONAHA.108.783654. DO - 10.1161/CIRCULATIONAHA.108.783654. M3 - Review article. C2 - 18955676. AN - SCOPUS:56549109039. VL - 118. SP - 1854. EP - 1863. JO - Circulation. JF - Circulation. SN - 0009-7322. IS - 18. ER - ...
As many as 450,000 Americans die every year from a sudden, fatal heart condition, and in slightly more than 1 in 10 cases the cause remains unexplained even after an autopsy. Researchers from the University of Maryland School of Medicine (UMSOM) and their colleagues found that nearly 1 in 5 patients with unexplained sudden cardiac death -most of whom were under age 50.
Young athletes should all be screened for sudden cardiac death prior to participation in sports. Heres what parents need to know.
The American College of Preventive Medicine (ACPM) supports an evaluation prior to participating in high school and collegiate sports using a standardized history and physical (H&P) (i.e., using standardized items as developed by the American Heart Association [AHA] to ensure uniformity and consistency in risk factor assessment [see the table below]). ACPM recommends against routine screening for potential sudden cardiac death (SCD) with electrocardiogram (ECG), echocardiography, and genetic testing in individuals without personal risk factors. The recommendations by ACPM address only mass screening approaches to detecting SCD and are not targeted toward individuals who may be identified by their healthcare provider as above average risk who may benefit from additional testing with the modalities mentioned above. ACPM supports the adoption of the National Heart, Lung, and Blood Institute (NHLBI) Working Group research agenda to evaluate the effectiveness of any screening program in reducing ...
Although epidemiological risk factors for sudden cardiac death (SCD) such as age, prior myocardial infarction and low ejection fraction are well established, the syndrome also has a strong genetic component. Identifying high-risk candidates and subsequent referral can significantly reduce the incidence of SCD among first-degree relatives.. ...
The incidence of sudden cardiac death in users of atypical anti-psychotics like clozapine, risperidone, quetiapine and olanzapine is almost twice that of individuals who do not take these drugs. Sudden cardiac death is a sudden pulseless condition that is fatal, precipitated by ventricular tachyarrhythmia in the absence of known non-cardiac cause. This risk of sudden cardiac death increases with increased dose of the anti-psychotic medications.. Of late atypical anti-psychotics are being increasingly prescribed and are replacing the older anti-psychotic drugs. The results were obtained from a retrospective cohort trail that involved 93,300 users of anti-psychotic medications and 18300 matched controls. It is useful to note that typical anti-psychotics like haloperidol and thioridazine can also cause increased incidence of sudden cardiac death. One of the explanations provided is that anti-psychotics through blockade of potassium channels increase the prolongation of the cardiac repolarization, ...
More than 80 percent of all cases of sudden cardiac death occur in people who have significant coronary artery disease, but we currently do not have a medical test that consistently identifies patients at risk, said Sumeet S. Chugh, M.D., associate director of the Cedars-Sinai Heart Institute and director of Clinical Electrophysiology. Chugh is first author of an article in Circulation, now appearing online ahead of print. This research was conducted with colleagues in the Emergency Medicine and Pathology Departments at Oregon Health and Science University in Portland, as part of the ongoing Oregon Sudden Unexpected Death Study. Abnormal QT prolongation has significant potential for evaluating risk and developing prevention strategies, but there are many factors - some known and some not known - that contribute to QT prolongation. Diabetes and the use of certain medications were significant predictors of QT interval prolongation and sudden cardiac death risk in our study. However, the most ...
Sudden Cardiac Death Aspartame MSG Heart disease. Sudden Cardiac Death and Food Excitotoxin Additives by Russell L. Blaylock, MD. 2009. http://web.mac.com. Over 460,000 people per year are now dying of a disorder called of sudden cardiac death according to CDC statistics. This is a condition striking otherwise healthy people, who have experienced no obvious symptoms of heart disease prior to their deaths. An alarming number of these deaths are occurring in young athletes, both in high schools, colleges, as well as among professional athletes.. While cardiologists have found coronary disease and suspect previous scars from silent heart attacks in a number of these individuals, one mechanism is getting no attention at all, and that is excitotoxic damage caused by food additives and the artificial sweetener aspartame. This is despite growing evidence that the excitotoxic mechanism plays a major role in cardiac disease.. Previously, it was thought that excitotoxin food additives, such as monosodium ...
This study included 267 SCA cases and 445 control subjects whose serum calcium levels were measured during routine medical care. All SCA cases had had serum calcium levels measured in the 90 days prior to their cardiac arrest.. The Oregon SUDS collaborates with emergency responders and hospitals in the Portland, OR metro area to identify all cases of sudden cardiac arrest. This enabled researchers to collect comprehensive patient medical history from the time prior to their cardiac arrest.. Each patient`s total serum calcium was corrected by their serum albumin level to estimate a more physiologically relevant corrected calcium level.SCA cases had a significantly higher percentage of African Americans and patients with diabetes mellitus, chronic obstructive pulmonary disease, and chronic kidney disease compared to the control group.. Cases were also more likely than controls to be on hemodialysis.In addition, diuretics, especially loop diuretics, were prescribed more for cases than for controls ...
TY - JOUR. T1 - Occupation and risk of sudden death in a United States community. T2 - A case-control analysis. AU - Zhang, Lin. AU - Narayanan, Kumar. AU - Suryadevara, Vallabh. AU - Teodorescu, Carmen. AU - Reinier, Kyndaron. AU - Uy-Evanado, Audrey. AU - Chugh, Harpriya. AU - Zheng, Zhi Jie. AU - Gunson, Karen. AU - Jui, Jonathan. AU - Chugh, Sumeet S.. PY - 2015. Y1 - 2015. N2 - Objective: Work environment is said to influence cardiovascular risk. We assessed whether nature of occupation affects risk of sudden cardiac death (SCD) in the general population. Methods: In the ongoing, prospective Oregon Sudden Unexpected Death Study (catchment population 1 million), working-age SCD cases (18-65 years) were compared with controls who died from any cause. Usual occupation obtained from death certificates was classified using the US Census Bureau standard occupational classification descriptions and categorised as white collar, blue collar or homemaker. Odds ratio (OR) for SCD by occupation ...
Evidence-based recommendations on subcutaneous implantable cardioverter defibrillator insertion for preventing sudden cardiac death
TY - CHAP. T1 - Non-steroidal anti-inflammatory drugs and increased risk of sudden cardiac death. AU - Hwang, Soyun M.. AU - Gilda, Jennifer E.. AU - Cui, Ziyou. AU - Gomes, Aldrin V. PY - 2013. Y1 - 2013. UR - http://www.scopus.com/inward/record.url?scp=84892089153&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84892089153&partnerID=8YFLogxK. M3 - Chapter. AN - SCOPUS:84892089153. SN - 9781626187863. SP - 123. EP - 167. BT - Sudden Cardiac Death: Epidemiology, Genetics and Predictive/Prevention Strategies. PB - Nova Science Publishers, Inc.. ER - ...
ABSTRACT: BACKGROUND: A variety of mutations in HERG, the major subunit of the rapidly activating component of the cardiac delayed rectifier I(Kr), have been found to underlie the congenital Long-QT syndrome, LQT2. LQT2 may give rise to severe arrhythmogenic phenotypes leading to sudden cardiac death. OBJECTIVE: We attempt to elucidate the mechanisms by which heterogeneous LQT2 genotypes can lead to prolongation of the action potential duration (APD) and consequently the QT interval on the ECG. METHODS: We develop Markovian models of wild-type (WT) and mutant I(Kr) channels and incorporate these models into a comprehensive model of the cardiac ventricular cell. RESULTS: Using this virtual transgenic cell model, we describe the effects of HERG mutations on the cardiac ventricular action potential (AP) and provide insight into the mechanism by which each defect results in a net loss of repolarizing current and prolongation of APD. CONCLUSIONS: This study demonstrates which mutations can prolong ...
While some published research has hinted at the connection between the sickle cell trait and sudden cardiac death among young, athletic African-American males, which was initially observed in black military recruits 25 years ...
The studies were analysed by the researchers from China, who compared patients treated with macrolides to similar patients treated with other antibiotic therapy, or with no antibiotics at all. The collected studies were conducted between 1966 and 2015.. The researchers found an average of 80 cases of ventricular tachyarrhythmias-rapid heartbeat that can lead to sudden cardiac death-per million treatment courses in patients who were not taking macrolides. The current use of macrolides accounted for an additional 118 ventricular tachyarrhythmias or related sudden cardiac deaths per million treatment courses; 36 additional sudden cardiac deaths from causes other than ventricular tachyarrhythmia; and 38 additional cardiovascular deaths per million treatment courses.. Past use of macrolides and use of other antibiotics were not associated with increased cardiovascular risk in the study. In addition, the use of macrolides was not associated with increased all-cause death, possibly because of the ...
There are few data regarding the incidence of ventricular arrhythmias beyond the immediate post-procedural period after ASA. In one series of 39 patients, programmed ventricular stimulation was performed before and 2 weeks after ASA; 60% of these patients had a repeat electrophysiology study at 7 months post-procedure as well (21). These investigators showed that there was actually a nonsignificant decrease in inducibility of VT/VF after the procedure. Additionally, the event-free survival in this group was 100% over a 15-month follow-up period. In a series of 50 patients who underwent ASA (21), 2 patients developed VF in the immediate post-procedure setting, but no patients developed sustained ventricular arrhythmias after 48 h out from their procedure. In another study, 9 patients who underwent ASA were followed up with serial Holter monitors at 3, 7, and 90 days after their intervention (23), and no ventricular arrhythmias were found with the exception of isolated premature ventricular ...
Hypertrophic Cardiomyopathy, Sudden Death, and Endocarditis. A small number of people with HCM have an increased risk of sudden cardiac death. People at risk include.: Those who have family members who have had sudden cardiac death. Young people with HCM who have had several episodes of fainting. Those who have an abnormal blood pressure response with exercise. Adults who have a history of arrhythmia with a fast heart rate. Those with severe symptoms and poor heart function. If you have two or more risk factors for sudden cardiac death, your doctor will treat you with medications to prevent arrhythmias or with an ICD. Most people with HCM are at low risk for sudden cardiac death. Talk to your doctor about any concerns you may have. How Can I Prevent Endocarditis? People with obstructive HCM may be at increased risk for infective endocarditis, a potentially life-threatening condition ...
Background: Renin-angiotensin system inhibition (RASI) is frequently avoided in aortic stenosis (AS) patients because of fear of hypotension. We evaluated if RASI with angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) increased mortality in patients with mild to moderate AS. Methods: All patients (n = 1873) from the Simvastatin and Ezetimibe in Aortic Stenosis study: asymptomatic patients with AS and preserved left ventricular (LV) ejection fraction were included. Risks of sudden cardiac death (SCD), cardiovascular death and all-cause mortality according to RASI treatment were analyzed by multivariable time-varying Cox models and propensity score matched analyses. Results: 769 (41%) patients received RASI. During a median follow-up of 4.3 +/- 0.9 years, 678 patients were categorized as having severe AS, 545 underwent aortic valve replacement, 40 SCDs, 103 cardiovascular and 205 all-cause deaths occurred. RASI was not associated with SCD (HR: 1.19 [95% CI: ...
Unfortunately, of all patients experiencing acute myocardial infarction (MI), usually in the form of ST-elevation MI, 25-35% will die of sudden cardiac death (SCD) before receiving medical attention, most often from ventricular fibrillation. For pati
Background- Sudden cardiac death among orthotopic heart transplant recipients is an important mechanism of death after cardiac transplantation. The role for implantable cardioverter-defibrillators (ICDs) in this population is not well established. This study sought to determine whether ICDs are effective in preventing Sudden cardiac death in high-risk heart transplant recipients.. Methods and Results- We retrospectively analyzed the records of all orthotopic heart transplant patients who had ICD implantation between January 1995 and December 2005 at 5 heart transplant centers. Thirty-six patients were considered high risk for sudden cardiac death. The mean age at orthotopic heart transplant was 44±14 years, the majority being male (n=29). The mean age at ICD implantation was 52±14 years, whereas the average time from orthotopic heart transplant to ICD implant was 8 years ±6 years. The main indications for ICD implantation were severe allograft vasculopathy (n=12), unexplained syncope (n=9), ...
BERLIN, GERMANY. Dr. Emanuel Severus of the Berlin University points out that major depression is characterized by a deficiency of omega-3 fatty acids and that these acids possess powerful antiarrhythmic properties. He suggests that the missing link in the recently established association between major depression and sudden cardiac death may be the omega-3 fatty acid deficiency which characterizes both conditions ...
Sudden death in a young person is a devastating event for any family. Unfortunately, in many cases this can be the first presentation of an underlying heart condition in an otherwise healthy person. A range of inherited heart conditions can cause sudden death and therefore it is important to investigate family members following such an event. Inherited heart conditions can be broadly grouped into causing one of two types of problems in the heart - electrical or structural. Electrical problems include long QT and Brugada syndromes, while structural problems include hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy.. When a person dies suddenly, a post-mortem (also known as an autopsy) is often performed to determine why they died. Some heart conditions are more easily diagnosed at post-mortem than others. In particular, structural causes of sudden death can be determined at post-mortem since the heart may be thickened, enlarged or structures within the heart, such as ...
Indiana University School of Medicine researchers have found that Omega-3 fatty acids may protect dialysis patients from sudden cardiac death.
CORRESPONDENCE. Sudden cardiac arrest in the young - a call to action. To the Editor: Sudden cardiac arrest (SCA) in athletes has once again been brought into the spotlight as a result of the recent widely publicised collapse and resuscitation of Fabrice Muambo during a FA Cup soccer match in the United Kingdom. The efforts of the trained medical responders in his successful resuscitation must be applauded. This incident resulted in the South African Premier Soccer League announcing more rigorous screening of players as a primary prevention measure. Sadly, Muambos case was followed by the sudden cardiac death of Olympic swimmer Alexander Dale Oen.. Electrocardiographic screening of athletes for cardiac abnormalities forms part of a sound primary prevention strategy.1 A major remaining challenge is the unpredictability of SCA in unscreened athletes, as only a minority will be screened. Another cause of SCA, commotion cordis, can occur when young athletes with structurally normal hearts sustain a ...
Bryan Heart is first in the region to treat patients who suffer from sudden cardiac arrest with an implantable cardioverter defibrillator (ICD).
Many people live for years with symptoms of heart failure. However, heart failure is a serious, progressive disease that can eventually cause or contribute to death. The symptoms of heart failure occur because the heart muscle has suffered damage and cant keep up with the bodys needs. The hearts enlargement and inability to pump tend to increase with time.. Also, heart failure patients can be more prone to abnormal heart rhythms, which increase the risk of sudden death. From 1993-2003, deaths from heart failure increased 20.5%3. People with heart failure usually die of either pump failure or sudden cardiac death.. Many heart failure deaths occur suddenly. You may have heard this problem described as cardiac arrest or sudden cardiac death (SCD).. What happens when someone has a sudden death event? The electrical impulses telling the heart to contract are sent too quickly through the heart muscle. The heartbeat becomes so rapid and chaotic that blood cannot move through the hearts chambers. ...
Routinely implanting pager-size defibrillators in heart attack survivors to stop cardiac arrest reduces their chance of dying by a surprising one-third and could benefit millions of Americans, a major study found.
Lets start with an analogy from the athletic pre-participation physical: Cardiovascular Screening. In order to reduce sudden cardiac death in athletes, current guidelines recommend that an athlete undergo 12 tests including: targeted questions of personal and family history, heart murmur, femoral pulses to exclude aortic coarctation, physical stigmata of Marfans syndrome, and brachial artery blood pressure (standard blood pressure reading).1 This screening protocol has a low sensitivity for detecting conditions related to sudden cardiac death, so there has been extensive discussion in the literature about adding 12 lead EKG to the screening protocol. The use of 12 lead EKG is under great debate because of its high false positive rate (between 15 and 40%), the associated medical costs, and the lack of qualified personnel to interpret the results. Whats interesting about this is that even with the addition of EKG, every cardiac condition predisposing young athletes to sudden cardiac death is ...
PMCMP : Sudden cardiac death (SCD) is estimated to occur at an incidence of between 50 to 100 per 100,000 individuals in North America and Europe each year, claiming between 250,000 and 450,000 lives in the United States annually. In younger individuals (ages 15-35), the incidence of SCD is between 1 to 2 per 100,000 young individuals. Sudden cardiac death, particularly in young individuals, may suggest an inherited form of heart disease. In some cases of sudden cardiac death, autopsy may identify a structural abnormality such as a form of cardiomyopathy. Postmortem diagnosis of a hereditary cardiomyopathy may assist in confirmation of the cause and manner of death, as well as risk assessment in living family members.   The cardiomyopathies are a group of disorders characterized by disease of the heart muscle. Cardiomyopathies are often caused by inherited, genetic, factors. When the identified structural or functional abnormality observed in a patient cannot be explained by acquired causes,
WEDNESDAY, June 20, 2018 (HealthDay News) -- Hidden drug overdoses account for nearly 1 in 7 sudden cardiac deaths, a new study contends.. Researchers looked at more than 900 people in San Francisco who died of an apparent out-of-hospital cardiac arrest.. Through autopsies and lab tests, they found that only 541 of those people (59 percent) actually met the criteria set by the World Health Organization for sudden cardiac death.. Of those cases, 13.5 percent (nearly 1 in 7) were due to a hidden overdose, with lethal levels of opioids found in 61 percent of them.. The study also found significant racial and gender differences. This highlights the importance of investigating apparent sudden cardiac death in women and different groups of people, according to the researchers from the University of California, San Francisco, and the City and County of San Francisco Office of the Chief Medical Examiner.. Our findings demonstrate the poor accuracy of our current, widely adopted definitions for sudden ...
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Although AIDS remained the leading cause of mortality, SCD was disproportionately represented in this urban HIV-infected cohort, accounting for 13% of all deaths and 86% of cardiac deaths, at a rate 4.5-fold higher than expected. Compared with AIDS deaths, SCDs occurred in older patients with better control of their HIV disease, as measured by CD4 count and viral load.. In the general population, most SCD is due to coronary artery disease (15). SCDs in this cohort reflect the age (mean 49 years) and sex distribution (93% male) of patients with HIV presenting with acute coronary syndromes (5), and prior MI was strongly associated with SCD. This study also replicates in the HIV population other risk factors associated with SCD: cardiomyopathy (16), heart failure (17), arrhythmias (18), hypertension (19), and hyperlipidemia (19).. Patients with SCD had modest immunodeficiency, with similar CD4 counts (median 312 cells/mm3) and viral loads (median 3.8 log copies/ml) as the full cohort (353 cells/mm3 ...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially fatal cardiac arrhythmia in individuals with a structurally normal heart. The disorder is characterized by syncope, typically beginning in the first decade of life, which may be triggered by physical activity or intense emotion. In patients with CPVT, stress- induced release of catecholamines causes a dysfunction of calcium-ion channel in myocytes. The ion channel dysfunction induces ventricular arrhythmias, which can lead to syncope or sudden cardiac death. Spontaneous recovery from the arrhythmia is possible, but the ventricular tachycardia can progress to ventricular fibrillation and sudden death. The incidence of CPVT within the population is not precisely known, but is estimated to be 1:10,000. Symptoms include syncope, dizziness, arrhythmia, and sudden cardiac death. Diagnosis may prove difficult, due to normal echocardiogram and electrocardiogram at a resting state. Testing must be performed under ...
Sudden Cardiac Arrest is the condition in which the heart unexpectedly ceases to function. Often, this is because of irregular and rapid quivering of the hearts lower pumping chambers (ventricles) called ventricular fibrillation. When this occurs, blood stops flowing to the brain and other vital organs, causing loss of consciousness or seizure-like activity in seconds.. If not treated within minutes, SCA results in death. The normal rhythm of the heart can only be restored with defibrillation, an electrical shock that is safely delivered to the chest by an automated external defibrillator (AED).. Sudden Cardiac Arrest is frequently the outcome of an underlying heart condition. It can also occur secondary to other conditions such as impact to the chest, heat stroke, asthma, drowning, electrocution, allergic reaction, or medication.. Sudden Cardiac Arrest is indiscriminate as to age, race or gender and kills over 300,000 Americans each year. Victims of SCA may never experience any warning ...
INDIANAPOLIS -- An electrocardiogram with severe abnormalities may predict the risk of sudden death for patients with the most common form of adult muscular dystrophy, according to a multicenter study
Background- Pharmacological interventions for prevention of sudden arrhythmic death in patients with chronic heart failure remain limited. Accumulating evidence suggests increased ventricular expression of T-type Ca2+ channels contributes to the progression of heart failure. The ability of T-type Ca2+ channel blockade to prevent lethal arrhythmias associated with heart failure has never been tested, however.. Methods and Results- We compared the effects of efonidipine and mibefradil, dual T- and L-type Ca2+ channel blockers, with those of nitrendipine, a selective L-type Ca2+ channel blocker, on survival and arrhythmogenicity in a cardiac-specific, dominant-negative form of neuron-restrictive silencer factor transgenic mice (dnNRSF-Tg), which is a useful mouse model of dilated cardiomyopathy leading to sudden death. Efonidipine, but not nitrendipine, substantially improved survival among dnNRSF-Tg mice. Arrhythmogenicity was dramatically reduced in dnNRSF-Tg mice treated with efonidipine or ...
Dundalk FC leant support to Cardiac Risk in the Young (CRY) by wearing t-shirts highlighting the charity to help raise awareness of Sudden Cardiac...
The Sudden Cardiac Arrest Foundation is a Non-Profit organization dedicated toward increasing awareness about sudden cardiac arrest. Join the SCA Community for SCA News, participate in the discussion forum, community blogs, share advice and gain insight.
The Sudden Cardiac Arrest Foundation is a Non-Profit organization dedicated toward increasing awareness about sudden cardiac arrest. Join the SCA Community for SCA News, participate in the discussion forum, community blogs, share advice and gain insight.
What is sudden cardiac arrest? Though a heart attack occurs when circulation of blood is blocked, cardiac arrest is the result of electrical disturbances that cause the heart to suddenly stop beating. Sudden cardiac Protect: Add Any Anti-oxidant Serum To Your Skin And Allow To Soak In May Be Combined With Your Moisturizer. , More Aiden Jackson death is an electrical problem, where your hearts rhythm is rapid and irregular and your heart cant pump effectively, so you suddenly collapse, Goldberg said. As you might expect, a sudden, unexpected loss of heart function results in an equally sudden loss of breathing and consciousness. Survival is possible after sudden cardiac arrest, with treatment. Once again, CPR, a defibrillator or chest compressions could save someones life until emergency personnel arrive. One cause of sudden cardiac arrest is a heart attack. Sometimes, people who are having heart attack have a complication of sudden cardiac death if they dont get to the hospital soon enough, ...
Aim. Studying the effect of β-blocker bisoprolol (Concor, «Nycomed») on remodeling, diastolic filling of both ventricles, myocardial ectopic activity, and heart rhythm variability in patients with AH. Materials and methods. Forty-six patients with degree 1-2 AH were evaluated. EchoCG, Holter ECG monitoring and 24-hour BP monitoring were conducted. Results. In patients with AH, bisoprolol slowed progression of cardiovascular remodeling, normalized structural and geometric parameters of the heart and ventricular diastolic filling, reduced autonomic sympathetic tone and ectopic activity of the myocardium, and thereby reduced the risk of sudden arrhythmic death ...
cardiac arrhythmia or sudden death. *seizure. A grading scale (0-5) is used depending on the presence of lab TLS, serum ... Massive cell death and nuclear breakdown generates large quantities of nucleic acids. Of these, the purines (adenine and ... cardiac arrhythmias, and death.[2][needs update][3] ... cardiac conduction abnormalities (can be fatal). *severe muscle ...
"Sudden Cardiac Death: Heart Failure Clinics". Elsevier Health Sciences - via Google Books.. ... Cardiac stress test Bruce protocol. Electrophysiology study. Cardiac imaging. Angiocardiography. Echocardiography TTE. TEE. ... Cardiac vessels. CHD. Angioplasty. Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent ... A cardiac electrophysiology study (EP test or EP study) is a minimally invasive procedure that tests the electrical conduction ...
An implantable ICD is more effective than drug therapy for prevention of sudden cardiac death due to VT and VF, but may be ... "Ventricular arrhythmias and sudden cardiac death". Lancet. 380 (9852): 1520-9. doi:10.1016/S0140-6736(12)61413-5. PMID 23101719 ... ventricular tachycardia and in the monomorphic form coincides with little or no increased risk of sudden cardiac death. In ... In those with cardiac arrest due to ventricular tachycardia, survival is about 45%.[1] An implantable cardiac defibrillator or ...
Deaths. 8% of sudden cardiac death[2]. Brugada syndrome (BrS) is a genetic disorder in which the electrical activity within the ... Nakajima K, Takeichi S, Nakajima Y, Fujita MQ (April 2011). "Pokkuri Death Syndrome; sudden cardiac death cases without ... There is no cure for Brugada syndrome.[3] Those at higher risk of sudden cardiac death may be treated using an implantable ... Kautzner J, Peichl P (June 2017). "Catheter ablation to prevent sudden cardiac death". International Journal of Cardiology. 237 ...
1996). "Sudden cardiac death triggered by an earthquake". New England Journal of Medicine. 334 (4): 413-419. doi:10.1056/ ... 1997). "Population-Based Analysis of the Effect of the Northridge Earthquake on Cardiac Death in Los Angeles County, California ... a b c Reich, K. Study raises Northridge quake death toll to 72. Los Angeles Times December 20, 1995 ... Details of some disaster-related deaths are released", Los Angeles Times. *^ Erdmann, Terry J.; Paula M. Block (2010-03-29). ...
Sudden cardiac death. T. *Truncus arteriosus. V. *Ventricular tachycardia. Retrieved from "https://simple.wikipedia.org/w/index ...
It fails to acknowledge the age at which relatives suffered sudden cardiac death, as well as the frequency of the cardiac ... though it did not contribute to his death and his family was not informed. The sudden cardiac death of his 31-year-old son in ... As of 2010, however, studies have shown that the incidence of sudden cardiac death, among all people with HCM, has declined to ... HCM is the leading cause of sudden cardiac death in young athletes in the United States, and the most common genetic ...
Cardiac reactions[edit]. Domperidone use is associated with an increased risk of sudden cardiac death (by 70%)[38] most likely ... "A case of sudden cardiac death following Domperidone self-medication". Forensic Science International. 254: e1-e3. doi:10.1016/ ... "Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control ... "Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands". Drug ...
J.A. MacWilliam: Cardiac failure and sudden death Br Med J, 1 (1889), pp. 6-8 J.A. MacWilliam: Some applications of physiology ... "Evolutionary biology and sudden cardiac death". Journal of the American College of Cardiology. 4 (7): 1843-1849. doi:10.1016/ ... and was the first person to propose that ventricular fibrillation was the most common cause of sudden death - and that ... surmising that this arrythmia was the cause of sudden death. After returning from the continent, MacWilliam received his M.D. ...
Ventricular fibrillation is a major cause of cardiac arrest, or sudden cardiac death, which accounts for about 10% of mortality ... Further studies have focused on the enigmatic origin of 'sudden unexplained cardiac deaths': those for which no cause is found ... Michel Haïssaguerre's team showed that patients with sudden cardiac death and structurally normal hearts frequently had ... "Sudden Cardiac Death Prediction and Prevention". Circulation. 122 (22): 2335-2348. doi:10.1161/CIRCULATIONAHA.110.976092. PMC ...
"Cardiac Symptoms Before Sudden Cardiac Death Caused by Coronary Artery Disease: A Nationwide Study Among Young Danish People". ... The highest incident of sudden cardiac death (SCD) in youth is due to ischemic heart disease. According to a study on SCD ... Winkel, BG (2012). "Sudden Cardiac Death in Young Danes". Danish Medical Journal. 59 (2): B4403. PMID 22293060. Jabbari, Reza; ... In 35-40% of unexplained youth deaths, genetic alterations in genes involved in the cardiac action potential is the cause. ...
Marsman RF, Wilde AA, Bezzina CR (Feb 2011). "Genetic predisposition for sudden cardiac death in myocardial ischaemia: the ... Chopra N, Knollmann BC (May 2011). "Genetics of sudden cardiac death syndromes". Current Opinion in Cardiology. 26 (3): 196-203 ... Patients exhibiting sudden death from acute myocardial infarction had a higher proportion of active coxsackie B virus infection ... Cardiac-specific knockout of CAR causes first degree block or complete block in the propagation of electrical conduction in the ...
"Sudden Cardiac Death Following Use of the Synthetic Cannabinoid MDMB-CHMICA". Journal of Analytical Toxicology. 40 (1): 86-87. ... 71 serious adverse events, including 42 acute intoxications and 29 deaths (Germany (5), Hungary (3), Poland (1), Sweden (9), ... "Drug Alert: Dangerous Synthetic Cannabinoid MMB-CHMINACA Causing Hospitalizations, Deaths in Europe". TalkingDrugs. 2 July 2015 ...
Kohl P, Nesbitt AD, Cooper PJ, Lei M (May 2001). "Sudden cardiac death by Commotio cordis: role of mechano-electric feedback". ... Commotio cordis is a very rare event, but nonetheless is often considered when an athlete presents with sudden cardiac death. ... Geddes LA, Roeder RA (January 2005). "Evolution of our knowledge of sudden death due to commotio cordis". The American Journal ... Touch of Death. References[edit]. *^ a b c Maron BJ, Estes NA (March 2010). "Commotio cordis". The New England Journal of ...
Kundu A, Vaze A, Sardar P, Nagy A, Aronow WS, Botkin NF (March 2018). "Variant Angina and Aborted Sudden Cardiac Death". ... vasospastic angina and sudden death), a new type of coronary arteritis: report of seven autopsy cases and a review of the ... Individuals who develop cardiac chest pain are generally treated empirically as an "acute coronary syndrome", and are ... Seven major factors (i.e. history of out of hospital cardiac arrest [score = 4]; smoking, angina at rest, physically ...
"Detailed analysis of 24 hour ambulatory ECG recordings during sudden cardiac death." Harvard Medical School: American Journal ...
"Cardiac Arrhythmias, Pacing and Sudden Death" (2017). His most-cited publications include: Singh BN, Hohnloser SH, Connolly SJ ... He has edited or co-edited three peer-reviewed journal supplements and several books, including "Cardiac Arrhythmia: Mechanisms ...
Interventions that augment HRV may be protective against cardiac mortality and sudden cardiac death. Although the rationale for ... Victims of sudden cardiac death have been found to have had lower HRV than healthy individuals. HRV can be observed to be ... Exercise training may decrease cardiovascular mortality and sudden cardiac death. Regular exercise training is also thought to ... subsequently suffering sudden cardiac death". Clinical Autonomic Research. 1 (3): 233-7. doi:10.1007/BF01824992. PMID 1822256. ...
More than a third of those with short QT present with ventricular arrhythmias or sudden cardiac death, while one in five cases ... and is associated with an increased risk of abnormal heart rhythms and sudden cardiac death. The syndrome gets its name from a ... a family history of sudden cardiac death aged ... This means that at certain points in the cardiac cycle, some ... fibrillation of the cardiac atria in atrial fibrillation leads to an irregular pulse, and fibrillation of the cardiac ...
1996). "Sudden cardiac death triggered by an earthquake". New England Journal of Medicine. 334 (4): 413-419. doi:10.1056/ ... 1997). "Population-Based Analysis of the Effect of the Northridge Earthquake on Cardiac Death in Los Angeles County, California ... The "official" death toll was placed at 57; 33 people died immediately or within a few days from injuries sustained, and many ... The death toll was 60, with more than 9,000 injured. In addition, property damage was estimated to be $13-50 billion ( ...
Sudden cardiac death of athletes List of basketball players who died during their careers "NBA G League player Zeke Upshaw ... Quinn, T.J. (March 24, 2020). "G League player's death spurs awareness of sudden cardiac arrest". ESPN.com. Retrieved March 25 ... Hendrix, Leon (March 27, 2018). "ME: Drive player collapse was a 'sudden cardiac death'". WOODTV.com. Archived from the ... Kent County medical examiner's preliminary determination after conducting an autopsy was that Upshaw had a sudden cardiac death ...
Hendrix, Leon (2018-03-28). "ME: Drive player collapse was a 'sudden cardiac death'". WOOD-TV. Nexstar Media Group. Retrieved ... Autopsy reports indicated that Upshaw had died from a sudden cardiac arrest. The start of the NBA G League playoffs were ... delayed out of respect for Upshaw's death, and the NBA's Detroit Pistons gave Upshaw an honorary call-up to their roster. "NBA ...
In 2016 Carlo Rola died of sudden cardiac death. Since February 24th 2020 Zoudé is a board member of Deutsche Filmakademie (The ...
It was diagnosed the cause was sudden cardiac death. Women's field hockey team promoted to Primera D (the fourth division) in ...
"Myocardial lipofuscin accumulation in ageing and sudden cardiac death". Scientific Reports. 9 (1): 3304. Bibcode:2019NatSR... ... Terman, A, Brunk, UT (1998). "On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes". Mech ... On the other hand, myocardial lipofuscin accumulation more directly reflects chronological ageing rather than human cardiac ...
In 2016, a systematic medical review found that the risk of sudden cardiac death during or immediately after a marathon was ... Waite O, Smith A, Madge L, Spring H, Noret N (January 2016). "Sudden cardiac death in marathons: a systematic review" (PDF). ... Lucero's cause of death was determined to be hyponatremic encephalopathy, a condition that causes swelling of the brain due to ... However, this review was not an attempt to assess the overall cardiac health impact of marathon running. A 2006 study of non- ...
Adegboyega, P. A.; Haque, A. K.; Boor, P. J. (Nov-Dec 1996). "Extensive myocytolysis as a marker of sudden cardiac death". ... This phenomenon tends to occur when neighboring cardiac muscle loses its ability to contract (i.e. in ischemia or infarction). ... Myocytolysis refers to a state of significant damage to cardiac myocytes, muscle cells of the heart, caused by myocardial ... strain to compensate for the loss of other muscles in order to deliver the necessary cardiac output. During the process, ...
Brittany J. Holmes; Nikolay G. Delev; Gary R. Pasternack; Marc K. Halushka (12 June 2012). "Novel cause of sudden cardiac death ... "Sudden coronary death due to IgG4-related disease". Cardiovascular Pathology. 22 (6): 505-507. doi:10.1016/j.carpath.2013.05. ... or even death if not treated. Early detection is important to avoid organ damage and potentially serious complications. ...
In 2016, a systematic medical review found that the risk of sudden cardiac death during or immediately after a marathon was ... The most-frequent causes are: sudden cardiac death, triggered by a congenital or acquired heart disorder; exercise-associated ... "Sudden cardiac death in marathons: a systematic review" (PDF). The Physician and Sportsmedicine. 44 (1): 79-84. doi:10.1080/ ... "Marathon death man named", BBC, 15 September 2003. "Marathon Runner Collapses, Dies", The Baltimore Sun, 11 October 2009. "Too ...
This causes death by respiratory failure leading to cerebral anoxia. No antidote is known, but if breathing can be kept going ... They can also contract their arms and surrounding web to make sudden moves known as "take-offs". Another form of locomotion is ... "The control of ventilatory and cardiac responses to changes in ambient oxygen tension and oxygen demand in Octopus". The ... exposure of muscle and death of octopuses in extreme cases.[107] ... "Hormonal Inhibition of Feeding and Death in Octopus: Control ...
Premature death. Stroke. Interrupted blood flow to the brain. Convulsions. Sudden, irregular body movements that can be violent ... Patients may survive into their late twenties, but generally suffer from early mortality due to cardiac, respiratory, and post- ... Because sudden excitement or fright can trigger a SIDA episode it is important to minimize exposure to startling stimuli. ... Depending on severity can lead to death. Medications, such as valproate Stimulus-induced drop attacks (SIDAs). Instantaneous ...
Deaths from snakebites are uncommon in many parts of the world, but are still counted in tens of thousands per year in India.[ ... cardiac involuntary muscles.[68] The main structures of the heart are the sinus venosus, the pacemaker, the left atrium, the ... This sudden collapse affected several large groups. Primitive tetrapods were particularly devastated, while stem-reptiles fared ...
... the loss of subcutaneous fat and beneficial mass from organs and muscle in addition to visceral fat when there is a sudden and ... "Mitochondrial Ion Channels: Gatekeepers of Life and Death". Physiology. 20 (5): 303-315. doi:10.1152/physiol.00020.2005. ISSN ... as well as improved cardiac health.[24] ...
... s are caused by trauma to the joint or when an individual falls on a specific joint.[4] Great and sudden force ... Dislocations are often caused by sudden trauma on the joint like an impact or fall. A joint dislocation can cause damage to the ...
Anaphylactic shock and subsequent cardiac arrest and sudden death are very rare, but because they occur within minutes, a ... causing cardiac arrest[12] and sudden death due to anaphylactic shock.[13][14] ... Intravenous use has the most reported adverse reactions, including sudden death, but this may reflect greater use rather than ... Both oral and topical uses have been reported to cause anaphylaxis,[15][16] including one case of anaphylaxis with cardiac ...
... lethal condition resulting in sudden infant death syndrome (SIDS),[9] infantile onset of a hepatic Reye-like syndrome, and late ... 2003). "Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I.". ... "Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 4 March 2016. Retrieved 23 March 2015.. ... a severe fatty acid oxidation disorder with cardiac and neurologic involvement". The Journal of Pediatrics. 142 (6): 684-9. doi ...
... or sudden weakness or numbness. A TIA may cause sudden dimming or loss of vision, aphasia, slurred speech, and mental confusion ... Stroke, shock, cardiac arrest and heart attack may cause stagnant hypoxia. Ischemic hypoxia can also be created by pressure on ... Prolonged hypoxia induces neuronal cell death via apoptosis, resulting in a hypoxic brain injury.[1][2] ... Geraghty M. C.; Torbey M. T. (2006). "Neuroimaging and serologic markers of neurologic injury after cardiac arrest". Neurol ...
Stroke and other cardiovascular disease are related to OSA and those under the age of 70 have an increased risk of early death. ... Shamsuzzaman AS, Gersh BJ, Somers VK (October 2003). "Obstructive sleep apnea: implications for cardiac and vascular disease". ... neurological mechanisms trigger a sudden interruption of sleep, called a neurological arousal. These arousals rarely result in ... "Obstructive sleep apnea as a risk factor for stroke and death". N. Engl. J. Med. 353 (19): 2034-41. doi:10.1056/NEJMoa043104. ...
CNS signs may appear, including numbness, increased sensation, muscle weakness, and sometimes cardiac or digestive dysfunction ... this fails to take into account the sudden rapid increase in tryptophan's usage immediately prior to the 1989 outbreak, and ... as well as at least 37 EMS-associated deaths. After preliminary investigation revealed that the outbreak was linked to intake ...
These devices are often used in the treatment of patients at risk from sudden cardiac death. An ICD has the ability to treat ... Large and/or sudden increases in impedance can be indicative of a lead fracture while large and/or sudden decreases in ... Main article: Cardiac resynchronization therapy. Cardiac resynchronization therapy (CRT) is used for people with heart failure ... Lidwell M C, "Cardiac Disease in Relation to Anaesthesia" in Transactions of the Third Session, Australasian Medical Congress, ...
... and cases of sudden cardiac death have been reported due to low potassium levels. Phenotypic variations observed among patients ...
Cardiac arrest. *Sudden cardiac death. *Asystole. *Pulseless electrical activity. *Sinoatrial arrest. Other / ungrouped. * ... Atrial fibrillation is one of the most common cardiac arrhythmias. In general, it is an irregular, narrow complex rhythm. ... Ventricular tachycardia (VT or V-tach) is a potentially life-threatening cardiac arrhythmia that originates in the ventricles. ... from healthy response to exercise or from cardiac arrhythmia), and that tachyarrhythmia be reserved for the pathologic form ( ...
The increase in respiration rate from the low range to the high range is sudden and occurs in response to hyperthermia. Birds ... When threatened, common ostriches run away, but they can cause serious injury and death with kicks from their powerful legs.[33 ... These purkinje fibers (p-fibers) found in the hearts moderator bands are a specialized cardiac muscle fiber that causes the ... it was estimated that two to three attacks that result in serious injury or death occur each year in the area of Oudtshoorn, ...
SADS, or sudden arrhythmia death syndrome, is a term used to describe sudden death due to cardiac arrest brought on by an ... Fatty acids play an important role in the life and death of cardiac cells because they are essential fuels for mechanical and ... The most common cause of sudden death in the US is coronary artery disease. Approximately 300,000 people die suddenly of this ... Also, there are many inherited conditions and heart diseases that can affect young people that can cause sudden death. Many of ...
Some symptoms of sleep apnea overlap with those of ADNFLE, such as sudden awakening accompanied by a feeling of choking and on ... Sheth SG, Krauss G, Krumholz A, Li G (September 2004). "Mortality in epilepsy: driving fatalities vs other causes of death in ... the left vagus nerve is used because the right nerve plays a role in cardiac function). Although little is understood about the ... Mayes BN (February 2009). "Review: people with epilepsy have higher risk of death by drowning than the general population". ...
Unexpected death of a loved one. Sudden, unexpected death of a loved one is the most common traumatic event type reported in ... Christiansen DM (February 2017). "Posttraumatic stress disorder in parents following infant death: A systematic review". ... risk of developing PTSD after learning of the unexpected death of a loved one.[59] Because of the high prevalence of this type ... of traumatic event, unexpected death of a loved one accounts for approximately 20% of PTSD cases worldwide.[35] ...
We describe four cases of sudden death in adolescents associated with recreational sniffing of typewriter correction fluid ... "Cardiac Effects of Inhaled Typewriter Correction Fluid". Annals of Internal Medicine. 110 (1): 91-92. doi:10.7326/0003-4819- ... "Sudden Death in Adolescents Resulting From the Inhalation of Typewriter Correction Fluid". JAMA: The Journal of the American ... unconsciousness and death.[6] Fatal poisonings and illnesses linked to intentional inhalation of trichloroethane have been ...
Death by hyperventilation: a common and life-threatening problem during cardiopulmonary resuscitation. Critical Care Medicine ... Sudden severe barotrauma from self-inflating bag devices. Journal of Trauma 1996: 40:320-322. ... Part 8: Adult Advanced Cardiac Life Support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and ... In one case of failed resuscitation (leading to death), gastric insufflation in a 3-month-old boy put sufficient pressure ...
White nose syndrome is a condition associated with the deaths of millions of bats in the Eastern United States and Canada.[164] ... Cardiac output is directly derived from heart rate and stroke volume of the blood;[69] an active microbat can reach a heart ... which are thought to be more sensitive to sudden air pressure changes than the lungs of birds, making them more liable to fatal ... Five bats are used to symbolise the "Five Blessings": longevity, wealth, health, love of virtue and peaceful death.[254] The ...
Sudden cardiac death. *Asystole. *Pulseless electrical activity. *Sinoatrial arrest. Other / ungrouped. *hexaxial reference ...
... cardiac tamponade), stroke, damage to the esophagus (atrio-esophageal fistula), or even death.[76][117] ... and sudden onset of shortness of breath during the night. This may progress to swelling of the lower extremities, a ... Deaths. 193,300 with atrial flutter (2015)[10]. Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm (arrhythmia) ... involved in the regulation of cardiac conduction, modulation of ion channels and in cardiac development. Have been also ...
The risk of death in hepatorenal syndrome is very high; the mortality of individuals with type 1 HRS is over 50% over the short ... and usually occurs when liver function deteriorates rapidly because of a sudden insult such as an infection, bleeding in the ... but that the measured femoral and kidney fractions of cardiac output are respectively increased and reduced, suggesting that ... The risk of death in hepatorenal syndrome is very high; consequently, there is a significant emphasis on the identification of ...
Behere, SP; Weindling, SN (2014). "Inherited arrhythmias: The cardiac channelopathies.". Annals of pediatric cardiology 8 (3): ... Sudden infant death syndrome (SIDS) is the sudden and unexpected death of a human baby which is unexplained even after an ... "A commentary on changing infant death rates and a plea to use sudden infant death syndrome as a cause of death". Forensic Sci ... A broader term, "sudden and unexpected infant death" (SUID) is used to describe all such deaths, regardless of cause. Cases of ...
... of all neonatal deaths.[13] In 2010 the worldwide death toll was 58,000 newborns. As the result of a public health campaign, ... The other type of striated muscle, cardiac, or heart muscle, cannot be tetanized because of its intrinsic electrical properties ... Prolonged muscular action causes sudden, powerful, and painful contractions of muscle groups, which is called "tetany". These ... In 2015 there were about 209,000 infections and about 59,000 deaths globally.[4][5] This is down from 356,000 deaths in 1990.[7 ...
... causes millions of deaths globally each year and is the most common cause of death in people who have been hospitalized. ... Rather it is often an adaptive microbial response to a sudden decline of host survival chances. Under this scenario, the ... higher cardiac output, and disorders in blood-clotting that may lead to organ failure.[18] Fever is the most common presenting ... with 11 million deaths (1 in 5 deaths worldwide).[14] In the developed world, approximately 0.2 to 3 people per 1000 are ...
Overdosage of emetine produces focal necrosis of cardiac muscle resulting in cardiac failure and sudden death. Emetine, like ... Many clinicians fear the occurrence of cardiac toxicity due to this drug and hence avoid using it. Serious cardiac toxicity, ...
Throughout his medical career, Lown focused on two major medical challenges: the problem of sudden cardiac death and the role ... His work made possible and safe much of modern cardiac surgery, as well as a host of other innovations. ... Lown developed the direct current defibrillator for cardiac resuscitation and the cardioverter for correcting rapid disordered ...
Of the 719,402 cardiac deaths in 1998, 74% were of the sudden-death variety. [Circulation Oct 30, 2001] The Omega Diet: The Li ... In over half of the cases sudden cardiac arrest occurs without prior symptoms. [Cleveland Clinic] The majority of sudden-death ... Sudden-death hearts attacks, defined as death within 1-hour of a sudden heart seizure, kills 325,000 Americans a year, or 890 ... Omega-3 fish oil and sudden cardiac death. There is also strong evidence that fish oil from oily fish or dietary supplements ...
Sudden Cardiac Death - The Role Of Aspartame, MSG And Other Excitotoxins. By Russell L. Blaylock, MD. 2-28-5. Over 460,000 ... omega-3 fat intake significantly increases the risk and severity of cardiac arrhythmias, the main cause of sudden cardiac death ... Both of these mechanisms have been shown to result in sudden cardiac death in experimental animals. A particular deadly ... called of sudden cardiac death according to CDC statistics. This is a condition striking otherwise healthy people, who have ...
... sudden cardiac death is very rare, despite the publicity, with only 20 to 25 sports-related sudden cardiac deaths from cardiac ... total death rates are higher, but the fraction of sudden deaths is lower; thus, the impact of reducing sudden cardiac death in ... of sudden cardiac deaths occurred at home. Emotional stress can be an important trigger for sudden cardiac death, as shown by ... a history of sudden cardiac death or sustained ventricular tachycardia, family history of sudden cardiac death, a diverse ...
... sudden cardiac death (SCD) takes the life of a young U.S. athlete, such as a girl playing soccer, a boy at basketball practice ... Every three days, sudden cardiac death (SCD) takes the life of a young U.S. athlete, such as a girl playing soccer, a boy at ... athletes suffered a sudden cardiac death each year from 2004 to 2008. The study also found that black athletes had a higher ... This simple heart test takes only a few minutes, and can mean the difference between life and death. "The American Heart ...
... is an unexpected death due to cardiac causes occurring in a short time period (generally within 1 h of symptom onset) in a ... Most cases of SCD are related to cardiac arrhythmias. ... Sudden Cardiac Death) and Sudden Cardiac Death What to Read ... Sudden cardiac death (SCD) is an unexpected death due to cardiac causes that occurs in a short time period (generally within 1 ... Sudden cardiac death (SCD) is an unexpected death due to cardiac causes occurring in a short time period (generally within 1 h ...
Sudden Cardiac Death News and Research. RSS The term sudden cardiac death refers to natural death from cardiac causes, heralded ... Low serum calcium levels linked to increased risk of sudden cardiac arrest Sudden cardiac arrest (SCA) is fatal for over 90% of ... Some heart disease patients face a higher risk of sudden cardiac death, which can happen when an arrhythmia -- an irregular ... Mitochondrial DNA copy number appears to be predictive of sudden cardiac death, heart attacks Johns Hopkins researchers report ...
The majority of the inherited cardiac diseases causing sudden death express themselves at variable ages in the form of altered ... Clinical cardiologists are encountering an important challenge in the caring of families with inherited cardiac diseases. ... Clinical Approach to Sudden Cardiac Death Syndromes. Editors. * Ramon Brugada Copyright. 2010. Publisher. Springer-Verlag ... Clinical Approach to Sudden Cardiac Death Syndromes details the main guidelines to clinicians on how to approach the patients ...
A new Danish study suggests that young people with diabetes may have seven times the risk of sudden cardiac death than young ... Sudden cardiac death. Sudden cardiac death is that which occurs as a result of sudden cardiac arrest, a deadly condition ... There are problems with giving accurate statistics on sudden cardiac arrest and sudden cardiac death, though, despite it being ... Sudden cardiac death - listed as the cause of death in 17 percent of those with diabetes (118 people) - was found to be seven ...
Christian Grov SUDDEN CARDIAC DEATH Author: Ghanshyam Patel MBBS, MPH EMPL... ... Introduction Of Sudden Cardiac Death. 2915 Words , 12 Pages. *. Awareness Of Sudden Cardiac Death In Youth Athletes.. ​Coresa. ... Awareness Of Sudden Cardiac Death In Youth Athletes.. ​Coresa. 1451 Words , 6 Pages. AWARENESS OF SUDDEN CARDIAC DEATH IN YOUTH ... Introduction Of Sudden Cardiac Death. 2915 Words , 12 Pages. Introduction Sudden cardiac death (SCD) is the leading cause of ...
... so you dont need to do the complex surgery to prevent sudden cardiac death. And if his sister has a more notched t-wave, then ... If a post-mortem doesnt find one, sudden arrhythmic death syndrome (SADS) is recorded as the cause. SADS can result from a ... and the same genetic problems may also play a role in sudden infant deaths. ... Virtual human hearts beating on supercomputers are helping get to the bottom of the most mysterious of heart diseases - sudden ...
In many people this is sudden and without warning. Sudden cardiac death happens as a result of a cardiac arrest and can happen ... This equates to around 10% of all Australian deaths that occur every year (153,000). Sudden cardiac death rates have not ... Prompt response to chest pain may avert cardiac arrest and sudden cardiac death in people suffering a heart attack. ... If the more unusual form of sudden cardiac death occurs in younger people - they might have a family history, or suffer from:. ...
... also known as sudden cardiac arrest) occurs from a sudden loss of heart function where the heart stops (cardiac arrest) and ... Sudden cardiac death (also known as sudden cardiac arrest) occurs from a sudden loss of heart function where the heart stops ( ... If you think you or someone you are with may be experiencing sudden cardiac death, it is important to call 9-1-1 immediately so ... Unlike a heart attack where plaque build up in the coronary arteries blocks blood flow to the heart, in sudden cardiac death ...
Home » sudden cardiac death. sudden cardiac death. SmartTeams Talk: Enacting Pro-Active Policies To Prevent Sudden Death in ... HCM and Sudden Cardiac Death in Young Athletes. About 50 young athletes go into sudden cardiac arrest each year and die from a ... Weve been asked by Gloria Wu, M.D., a physician active in the Sudden Cardiac Death Association of San Jose, California, and an ... Nearly 350,000 people suffer cardiac arrest annually. Because cardiac arrest leads to the death of one youth athlete every ...
Sudden cardiac death (SCD) has a devastating impact on the families of victims and society as a whole. Despite major advances ... MD to identify research barriers and outline possible solutions to prevent sudden cardiac death (SCD) in the general population ... Establish an SCD registry in adults, similar to the Sudden Death in Young Case Registry. This could include an autopsy element ... The Working Group consisted of experts in pediatric and adult cardiology, emergency care medicine, cardiac electrophysiology, ...
... according to this study on unexpected deaths in 2018. Learn why increased screening and prevention could help save lives. ... Obesity is a major risk factor of sudden cardiac death in young people, ... To be clear, sudden cardiac death is not synonymous with a heart attack. Sudden cardiac death or arrest is the result of sudden ... This study gathered information about people who experienced sudden cardiac death (SCD), also called sudden cardiac arrest (SCA ...
The abrupt cessation of effective cardiac function due to an aberrant heart rhythm can cause sudden and unexpected death at any ... a syndrome called sudden cardiac death (SCD). Annually, more than 300,000 cases of SCD occur in the United States alone, making ... the molecular physiology of cardiac ion channels, fundamental cellular and tissue events associated with cardiac arrhythmias, ...
... is an unexpected death due to cardiac causes occurring in a short time period (generally within 1 h of symptom onset) in a ... Most cases of SCD are related to cardiac arrhythmias. ... Sudden Cardiac Death) and Sudden Cardiac Death What to Read ... Cardiac death, sudden. Plots of mortality rates (deaths per 1000 persons) for ischemic heart disease occurring out of the ... Laboratory studies in the workup of sudden cardiac death include the following:. * Cardiac enzymes (creatine kinase, myoglobin ...
sudden cardiac death Sudden cardiac death can occur when someone in sudden cardiac arrest is not treated promptly. Sudden ... While the terms "sudden cardiac arrest" and "heart attack" are often used as if they are synonyms, they arent. Sudden cardiac ... Heart attacks increase the risk for sudden cardiac arrest, but most heart attacks do not lead to sudden cardiac arrest. ... Immediate CPR can double or triple the chances of survival from sudden cardiac arrest. ...
How Sudden Is Sudden Cardiac Death?. Dirk Müller, Rahul Agrawal, Hans-Richard Arntz ... Sudden cardiac death (SCD) is one of the most frequent causes of death in industrialized countries. The yearly incidence is ... In conclusion, our data show that "sudden cardiac death" is not nearly as sudden in most cases as the term may suggest. Warning ... Background- Out-of-hospital sudden cardiac death (SCD) is a frequent cause of death. Survival rates remain low despite ...
Genomics in sudden cardiac death. Circ Res. 2004;94:712-723. 14. Zipes DP, Wellens HJ. Sudden cardiac death. Circulation. 1998; ... Preventing tomorrows sudden cardiac death today: part I: current data on risk stratification for sudden cardiac death. Am ... Diabetes and Sudden Cardiac Death. Jennifer D. Smith, PharmD, CPP, BC-ADM, CDE. Associate Professor, Pharmacy Practice. ... Diabetes mellitus and sudden cardiac death: what are the data? Cardiol J. 2010;17:117-129. 9. El-Atat FA, McFarlane SI, Sowers ...
The burden of sudden cardiac death in terms of years of potential life lost is high compared with other leading causes of death ... Sudden Cardiac Death Robs Many Years of Life. The burden of sudden cardiac death in terms of years of potential life lost is ... In the current study, they examined death certificates, census data, and sudden cardiac death rates from the Oregon Sudden ... sudden cardiac death would lead to a life expectancy similar to that in a population that had not suffered sudden cardiac death ...
... of sudden deaths until 21 years of age. Fatal ventricular arrhythmias are usual common pathways in such tragic events, and ... Sudden cardiac death is rare in children and adolescents but accounts for 19% to 30% ... Sudden cardiac death is rare in children and adolescents but accounts for 19% to 30% of sudden deaths until 21 years of age. ... We present a case of aborted sudden cardiac death in field, resuscitated successfully, and a clinical event in the pediatric ...
It is estimated that approximately 1,000 children die of sudden death each year. ... Sudden cardiac death is the most common mode of death in this country with more than 300,000 deaths per year, a third of which ... Sudden cardiac death is the most common mode of death in this country with more than 300,000 deaths per year, a third of which ... While commotio cordis is rare, most young athletes who die of sudden cardiac death have an underlying cardiac abnormality. The ...
Oregon-SUDS and discovered that a polymorphism in the GNAS gene predicted ventricular tachyarrhythmias and sudden cardiac death ... A gene associated with sudden cardiac death in the general population has been identified using implantable cardioverter ... Sudden cardiac death is one of the leading causes of death in Western countries and cardiac arrhythmias have been reported as ... Sudden Unexpected Death Study), a community-based study analysing causes of sudden cardiac death in the Portland, Oregon ...
Sudden cardiac death during exertion is an extremely rare occurrence in women, and regular moderate to vigorous exercise may ... studies have also documented associations between incidents of exertion and sudden cardiac death. Although such deaths are ... Sudden cardiac death during exertion is an extremely rare occurrence in women, and regular moderate to vigorous exercise may ... Risk of sudden cardiac death was temporarily elevated during moderate to vigorous exertion, compared with the risk during ...
Sudden Cardiac Death. SCD was defined as a sudden pulseless condition from a cardiac origin in a previously stable individual ... Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol. 2006;47:362-367. ... Vitamin D, Parathyroid Hormone, and Sudden Cardiac Death. Results From the Cardiovascular Health Study. Rajat Deo, Ronit Katz, ... Vitamin D, Parathyroid Hormone, and Sudden Cardiac Death. Rajat Deo, Ronit Katz, Michael G. Shlipak, Nona Sotoodehnia, Bruce M ...
Without quick treatment, it causes sudden cardiac death. Find out more. ... In sudden cardiac arrest (SCA), an irregular heart rhythm causes the heart to stop beating. ... Sudden Cardiac Arrest (Texas Heart Institute) Also in Spanish * What Is Sudden Cardiac Arrest? (National Heart, Lung, and Blood ... What is sudden cardiac arrest (SCA)?. Sudden cardiac arrest (SCA) is a condition in which the heart suddenly stops beating. ...
... a common culprit in cases of sudden death in young athletes. A team of Harvard scientists and colleagues used some of these ... Pioneering discovery leads to potential preventive treatment for sudden cardiac death. University of Vermont ... a common culprit in cases of sudden death in young athletes.. Now, a team of scientists has used some of Warshaws earlier ... "For the heart, this amounts to inducing cardiac fibrosis and muscle cell disarray that are characteristic of HCM patients." ...
  • CHD), NIOSH investigators concluded that an arrhythmia probably triggered his sudden cardiac death. (cdc.gov)
  • 1 2 Such a rapid death is often attributed to a cardiac arrhythmia, but with the advent of monitoring capabilities from implantable cardioverter-defibrillators (ICDs), it is now well recognized that classifications based on clinical circumstances can be misleading and often impossible, because 40% of sudden deaths can be unwitnessed. (ahajournals.org)
  • 3 Only an ECG or a ventricular electrogram recorded from an implanted device at the time of death can provide definitive information about an arrhythmia. (ahajournals.org)
  • A medicinal plant frequently used in Traditional Chinese Medicine (TCM) - Evodia rutaecarpa - contains substances that can cause cardiac arrhythmia. (news-medical.net)
  • To prevent cardiac death, people with certain cardiac disorders are implanted with electronic devices designed to automatically stimulate the heartbeat or counteract serious arrhythmia if necessary. (news-medical.net)
  • Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, and its prevalence is projected to rise continuously over the next few decades because of an aging population. (news-medical.net)
  • Some heart disease patients face a higher risk of sudden cardiac death, which can happen when an arrhythmia -- an irregular heartbeat-- disrupts the normal electrical activity in the heart and causes the organ to stop pumping. (news-medical.net)
  • Electrolytes, calcium, and magnesium: Severe metabolic acidosis, hypokalemia, hyperkalemia, hypocalcemia, and hypomagnesemia are some of the conditions that can increase the risk for arrhythmia and sudden death. (medscape.com)
  • Subtherapeutic levels of these drugs in patients being treated for specific cardiac conditions also can lead to an increased risk for arrhythmia. (medscape.com)
  • ICDs are indicated for patients who either have survived a life threatening cardiac arrhythmia or have a high risk for sudden cardiac death due to cardiac arrhythmias. (eurekalert.org)
  • ICDs were used to monitor and store cardiac arrhythmia data to study whether specific genes were associated with an increased risk of potentially life-threatening ventricular tachyarrhythmias. (eurekalert.org)
  • UC Irvine researchers have found a specific genetic flaw that is connected to sudden death due to heart arrhythmia - a leading cause of mortality for adults around the world. (news-medical.net)
  • In the current study, the researchers expanded on their previous work by showing that KCNE2 disruptions affect these rhythms in cardiac cells, which increases the risk of arrhythmia. (news-medical.net)
  • The single sudden death due to an arrhythmia (in the absence of advanced heart failure) resulted from ICD malfunction. (nih.gov)
  • More than enough, it turns out, to protect the animals from cardiac arrhythmias abnormal heart rhythms such as ventricular tachycardia and ventricular fibrillation that can lead to sudden cardiac death according to a new study of the hibernating animals that may provide insight into arrhythmia therapies. (medicalxpress.com)
  • These studies have identified an increased risk for arrhythmia (abnormal heart rhythms), conduction defects, cardiomyopathy and sudden cardiac death. (clinicaltrials.gov)
  • Although cardiac conditions are frequently suspected as a cause of death, SD racehorses are often autopsy negative thus similar to autopsy-negative SD in humans which can be associated with inherited fatal arrhythmia syndromes. (cornell.edu)
  • The prevailing hypothesis regarding the mechanism of sudden cardiac death involves the superimposition of a 'trigger' or 'transient risk factor' acting in concert with the anatomical substrate to perturb cardiovascular function and produce the final common pathway of a fatal arrhythmia, usually VT deteriorating into VF. (forensicmed.co.uk)
  • Biobehavioral factors in cardiac arrhythmia pilot study (caps). (biomedsearch.com)
  • An alarming number of these deaths are occurring in young athletes, both in high schools, colleges, as well as among professional athletes. (rense.com)
  • When magnesium stores are low, as we see in athletes, the glutamate receptors are so sensitive that even low levels of these excitotoxins can result in cardiac arrhythmias and death. (rense.com)
  • Anomalous origin of a coronary artery (AOCA) can be associated with sudden cardiac death (SCD), particularly in young athletes. (nih.gov)
  • But recent research indicates it is actually the leading cause of death among young athletes. (chicagotribune.com)
  • Investigators from the University of Washington found that one in 43,770 National Collegiate Athletic Association (NCAA) athletes suffered a sudden cardiac death each year from 2004 to 2008. (chicagotribune.com)
  • Introduction Sudden cardiac death (SCD) is the leading cause of death in exercising young athletes. (bartleby.com)
  • 2 Such deaths often receive more attention because of the youth of the victims and the perception that physically trained athletes are healthy. (bartleby.com)
  • The leading expert on sudden death of youth athletes argues that youth sports safety policies need to be developed and implemented by sports medicine professionals, not athletic administrators, and notes that the level of risk of catastrophic sports injury often depends on how a state athletic association responds to the death of athletes in their states. (momsteam.com)
  • We've been asked by Gloria Wu, M.D., a physician active in the Sudden Cardiac Death Association of San Jose, California, and an Associate Clinical Professor at Tufts University School of Medicine, for help on a research project she is working on in the area of health screening (a/k/a pre-participation physical evaluations) and its importance to athletes. (momsteam.com)
  • The death of young, seemingly healthy, athletes from undetected heart problems often generates considerable media attention and re-ignites the debate over the optimal approach to screening young competitive athletes for heart problems to minimize death from sudden cardiac arrest. (momsteam.com)
  • Sudden cardiac death (SCD) occurs rarely in athletes, but when it does happen, it often affects us with shock and disbelief. (clevelandclinic.org)
  • While commotio cordis is rare, most young athletes who die of sudden cardiac death have an underlying cardiac abnormality. (sun-sentinel.com)
  • Coronary artery disease, blockages in the arteries that deliver blood to the heart, can lead to a heart attack, the most common cause of sudden death over all age groups, though rare in young athletes. (sun-sentinel.com)
  • Congenital coronary abnormalities can result in fatal cardiac arrhythmias in young athletes. (sun-sentinel.com)
  • There is much debate regarding the routine screening of all athletes to assess risk of sudden death with electrocardiograms or echocardiograms (heart ultrasounds). (sun-sentinel.com)
  • More likely underlying undetected heart diseases cause the sudden cardiac death in athletes by predisposing the heart to acute cardiac arrest or ventricular fibrillation when it is overstrained during exercise. (biotronik.com)
  • Scientists have discovered an important enzyme molecule that may prevent fatal cardiac disorders associated with cardiac hypertrophy the leading cause of sudden cardiac death in young athletes. (medicalxpress.com)
  • Kuhn is one of hundreds of young athletes to fall victim to a heart attack or sudden cardiac arrest because of undiagnosed warning signs. (eveningsun.com)
  • According to the Peyton Walker Foundation - named for the former Trinity High School student who died of sudden cardiac arrest in 2013 at 19 - SCA is the No. 1 killer of student athletes in the United States and the No. 2 medical cause of death in people under 25. (eveningsun.com)
  • I think the big part of it is we have to educate our student athletes and parents on the topic and make them aware of (the dangers of sudden cardiac arrest),' Big Spring athletic director Joe Sinkovich said. (eveningsun.com)
  • The researchers say this study could indicate that sleep disordered breathing is a factor in the phenomenon of seemingly healthy young athletes dying from a sudden and unexplained heart attack. (eurekalert.org)
  • We tend to assume that young, competitive athletes will not experience conditions like SDB, which are more common in people with a higher BMI and inactive lifestyles, but more research is needed to determine what may be contributing to sudden cardiac death in athletes, and SDB is a good candidate for this as it can affect the heart's normal functions. (eurekalert.org)
  • Based on the link between SDB and abnormal heart functions that we observed in this group, we speculate that SDB could be a possible factor in the unexplained deaths of some young collision sport athletes, as it appears to be very prevalent but currently is not regularly screened for. (eurekalert.org)
  • 35 years) athletes gets a lot of public attention and is often of cardiac origin. (uio.no)
  • Athletes are at an increased risk of sudden cardiac death (SDC) and the main causes are heredetary. (uio.no)
  • Conclusions Heart screening of young athletes has yet to be proven cost effective and efficient in reducing sudden carciac arrests. (uio.no)
  • Some experts support the implementation of cardiovascular (i.e., electrocardiogram) screening programs for infants, athletes, or all children, to identify at-risk individuals and to prevent sudden cardiac death (SCD). (nih.gov)
  • By comparison, in Italy the rate of sudden death among athletes is estimated to be about 3 in 100,000, while in Norway the rate is estimated to be just under 1 in 100,000. (sharecare.com)
  • The differences in rates of sudden death may be due to differences in the mix of ages or genders in the groups studied, or it may reflect population-wide differences in the genetic make-up of the athletes. (sharecare.com)
  • Chelko's lab has published research providing important new insights about arrhythmogenic cardiomyopathy, a leading cause of sudden cardiac death among young athletes. (fsu.edu)
  • It remains a difficult medical challenge to prevent the sudden cardiac death of athletes, typically defined as natural, unexpected death from cardiac arrest within one hour of the onset of collapse symptoms, excluding additional time on mechanical life support. (wikipedia.org)
  • The sudden cardiac deaths of 387 young American athletes (under age 35) were analyzed in a 2003 medical review: While most causes of sudden cardiac death relate to congenital or acquired cardiovascular disease, an exception is commotio cordis, in which the heart is structurally normal but a potentially fatal loss of rhythm occurs because of the accident of timing of a blow to the chest. (wikipedia.org)
  • Congenital cardiovascular deaths are reported to occur disproportionately in African-American athletes. (wikipedia.org)
  • Particularly when we hear about sudden cardiac collapse and death in young athletes. (seattlechildrens.org)
  • Sudden deaths of young athletes bring attention to an important public health problem known as sudden cardiac death of the young (SCDY), which occurs in non-athletes, too. (cdc.gov)
  • She said: "It is too early to conclude that sleep disordered breathing is a definite factor in sudden cardiac death of athletes, but these results provide food for thought on the ways that breathing disorders may affect the health of young, fit athletes. (eurasiareview.com)
  • State Assemblyman Patrick Diegnan, D-Middlesex, the author of legislation designed to heighten HCM awareness and help prevent sudden cardiac death in student-athletes, will join the families for a ceremonial coin toss prior to the Edison-South Brunswick game. (njtoday.net)
  • Athletes comprise 20 percent of all HCM-related deaths in the United States. (njtoday.net)
  • Young black males are particularly at risk, accounting for about half of all sudden cardiac deaths in athletes, according to Lisa Salberg, CEO and founder of the Hibernia-based Hypertrophic Cardiomyopathy Association, a nonprofit group. (njtoday.net)
  • Researchers and cardiologists are working tirelessly to understand predictors for sudden cardiac death in children alongside techniques to improve screening and prevention for young athletes. (seattlechildrens.org)
  • The effects of intense physical training on the heart were first recognized when Darling and Henschen observed cardiac enlargement in athletes in 1899. (acc.org)
  • Sudden cardiac death (SCD) is the most frequent medical cause of sudden death in athletes, and estimates vary widely based on the population. (acc.org)
  • The causes of SCD in younger athletes is commonly due to inherited cardiac conditions, while in older athletes it is most often due to atherosclerotic coronary artery disease (Table). (acc.org)
  • Incidence, Etiology, and Comparative Frequency of Sudden Cardiac Death in NCAA Athletes: A Decade in Review. (acc.org)
  • What are the incidence and causes of sudden cardiac death (SCD) among college athletes? (acc.org)
  • Using participation, sex, and ethnicity data tracked by the National Collegiate Athletic Association (NCAA) for more than 450,000 student athletes annually, deaths in NCAA athletes were identified during the school years (July-June) from 2003-2004 to 2012-2013 using the NCAA Resolutions List, the Parent Heart Watch database, and NCAA insurance claims. (acc.org)
  • The recent deaths of two high school athletes from heart conditions raise scary questions for parents about their own kids' heart health and sports safety. (everydayhealth.com)
  • Everyday Health spoke to leading cardiologists about sudden cardiac death in young athletes to get the answers. (everydayhealth.com)
  • But in young athletes, more than half of sudden deaths are due to underlying heart disease , according to a study in the journal Circulation . (everydayhealth.com)
  • According to the Minneapolis Heart Institute Foundation, a leading center for research in the field, there are more than 30 identified causes of sudden death in athletes. (everydayhealth.com)
  • Sudden cardiac death in young athletes continues with alarming frequency. (howardluksmd.com)
  • How does HCM lead to death in athletes? (howardluksmd.com)
  • What is the cause of sudden death in athletes? (howardluksmd.com)
  • The majority of cases of sudden death in athletes are due to a heart muscle condition called hypertrophic cardiomyopathy, where the heart muscle is too thick. (howardluksmd.com)
  • Not all athletes with HCM will first present with sudden death. (howardluksmd.com)
  • The most common causes of sudden cardiac death in athletes are hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy. (bcmj.org)
  • Multiple studies have tried to determine the incidence of sudden cardiac death in athletes, but this has proven to be difficult because of differing definitions, inconsistent identification of causes of death, and geographic variation. (bcmj.org)
  • Further studies are needed to determine the cost-effectiveness of pre-participation screening programs for competitive athletes and to inform strategies that can reduce the burden of sudden cardiac death in this population. (bcmj.org)
  • 1 ] In addition to inherited disorders, other risk factors and conditions can predispose athletes to cardiac events. (bcmj.org)
  • In competitive athletes younger than age 35 (the focus of this article), the majority of sudden cardiac death cases are due to inherited heart diseases, whereas in masters athletes older than 35, most cases are due to coronary artery disease. (bcmj.org)
  • Practically speaking, the complex convergence of factors that leads to sudden cardiac death is poorly understood, since athletes are typically exercising at levels common for them, and there is no unique circumstance in the vast majority of cardiac arrests and sudden deaths. (bcmj.org)
  • Because they are more likely to also have coronary artery disease and other medical conditions, their risk of sudden cardiac death is even higher. (rense.com)
  • 1 Sudden cardiac death is the most common and often the first manifestation of coronary heart disease and is responsible for ≈50% of the mortality from cardiovascular disease in the United States and other developed countries. (ahajournals.org)
  • Several population-based studies have documented a 15% to 19% decline in the incidence of sudden cardiac deaths caused by coronary heart disease since the early 1980s. (ahajournals.org)
  • Nevertheless, their control, with concomitant reduction in death from coronary artery disease, is probably at least in part responsible for the reduction in overall sudden cardiac death. (ahajournals.org)
  • Coronary artery abnormalities and sudden cardiac death. (nih.gov)
  • SCD continues to be one of the leading causes of mortality worldwide, with an annual incidence estimated at 250000 to 300000 in the United States and with the vast majority occurring in the setting of coronary disease and other cardiac events. (bartleby.com)
  • The most common cause in adults is coronary heart disease, accounting for 80% of sudden cardiac deaths overall. (heartfoundation.org.au)
  • In people with coronary heart disease, cardiac arrest is often preceded by chest pain and other warning signs of heart attack. (heartfoundation.org.au)
  • Unlike a heart attack where plaque build up in the coronary arteries blocks blood flow to the heart, in sudden cardiac death the heart stops due to a malfunction of the heart's electrical system causing the heart to suddenly beat very rapid and irregular. (memorialcare.org)
  • Women, compared to men, have fewer cardiac structure abnormalities and lower recognized coronary disease before cardiac arrest occurs. (healthcentral.com)
  • The most common SCD-related conditions included sudden arrhythmic death syndrome (31 percent), coronary artery disease (22 percent), and hypertrophic cardiomyopathy (14 percent). (healthcentral.com)
  • Gibson et al found that pharmacologic-stress nuclear (dipyridamole or adenosine) scintigraphy was better than submaximal exercise ECG and coronary angiography in predicting cardiac death and other cardiac events. (medscape.com)
  • 6 Although the fundamental role of coronary heart disease and other causes of SCD, such as long-QT syndrome, has been described comprehensively, every single event seemingly represents a sudden and unforeseeable situation. (ahajournals.org)
  • And a side-benefit of lifestyle-based efforts to prevent sudden cardiac death, a rare condition, are the positive impact it can have on more common health problems, such as diabetes, stroke and coronary disease, she added. (reuters.com)
  • The most common cause of sudden cardiac death in middle-aged or older adults is coronary artery disease (CAD) . (biotronik.com)
  • The anatomical substrates for sudden cardiac death include coronary artery atherosclerosis, myocardial fibrosis and necrosis and left ventricular hypertrophy. (forensicmed.co.uk)
  • Of the 460,000 sudden deaths that occur annually in the United States , about 90% are due to coronary artery disease, and 75% of the victims are men. (harvard.edu)
  • The risk of sudden cardiac death is higher in men than in women, and it increases with age due to the higher prevalence of coronary artery disease in older age. (springer.com)
  • On the other hand, cardiac hypertrophy is more commonly reported among black patients, while coronary plaque rupture shows up more often on autopsies of white patients. (cardiovascularbusiness.com)
  • The significance of this study is that it shows that abdominal obesity is an independent risk factor for sudden cardiac death even after accounting for factors such as diabetes, hypertension, and coronary heart disease," Adabag said in a statement. (empr.com)
  • Physicians should make obesity prevention and treatment a priority to reduce the risk of coronary disease as well as sudden cardiac death. (empr.com)
  • Many cardiovascular conditions can predispose an athlete to sudden cardiac death, including hypertrophic cardiomyopathy, myocarditis, coronary artery anomalies, and electrical disorders such as Wolff-Parkinson-White syndrome. (bcmj.org)
  • Jervell and Lange-Nielsen syndrome & Romano-Ward syndrome), Brugada, Lev-Lenegre's syndrome) Wolff-Parkinson-White syndrome (WPW) Coronary artery anomaly (CAAs) Marfan syndrome Other cardiac conditions - Endocardial fibroelastosis (EFE), Tachycardia, Antibiotic prophylaxis, Eosinophilic granulomatosis with polyangiitis, Right bundle branch block (RBBB), Kawasaki disease On 15 July 2004 CRY launched its National Postcard Campaign to highlight the deaths of eight young people per week from undiagnosed heart problems by featuring their pictures. (wikipedia.org)
  • In over half of the cases sudden cardiac arrest occurs without prior symptoms. (lewrockwell.com)
  • Sudden cardiac death (SCD) is an unexpected death due to cardiac causes that occurs in a short time period (generally within 1 hour of symptom onset) in a person with known or unknown cardiac disease. (medscape.com)
  • Sudden cardiac death is that which occurs as a result of sudden cardiac arrest, a deadly condition wherein the heart suddenly stops pumping and cannot send blood to the lungs, brain, and other organs. (medicalnewstoday.com)
  • Sudden cardiac death (also known as sudden cardiac arrest) occurs from a sudden loss of heart function where the heart stops (cardiac arrest) and blood stops circulating in the body. (memorialcare.org)
  • Ventricular fibrillation, an abnormal heart rhythm that occurs in the lower chambers of the heart (ventricles), is life-threatening and a leading cause of sudden cardiac death. (memorialcare.org)
  • The prevention of sudden cardiac death is considered a public health challenge and it's of particular concern when it occurs in younger people. (healthcentral.com)
  • Sudden cardiac death often hits the news cycle when it occurs in a young athlete . (healthcentral.com)
  • Sudden cardiac death occurs most frequently in adults in their mid-30s to mid-40s, and affects men twice as often as it does women. (clevelandclinic.org)
  • In contrast, sudden cardiac arrest occurs when the electrical system to the heart malfunctions and suddenly becomes very irregular. (clevelandclinic.org)
  • When this occurs, the heart is unable to pump blood and death will occur within minutes, if left untreated. (clevelandclinic.org)
  • Sudden cardiac death most often occurs as the result of ventricular fibrillation (VF), an abrupt irregular heart rhythm that causes the heart to quiver inneffectively rather than pumping normally. (sun-sentinel.com)
  • Death occurs within an hour after the initial onset of symptoms. (biotronik.com)
  • The heart is no longer able to pump blood to the rest of the body, and in over 90 percent of victims, death occurs. (winespectator.com)
  • According to the study, full cardiac arrest normally occurs within one hour of any noticeable symptoms. (winespectator.com)
  • Distinct from a heart attack, in which the heart continues to beat but blood flow is blocked, sudden cardiac death occurs when the heart ceases to beat because of the uncontrolled twitching of muscle fibers in its ventricles. (news-medical.net)
  • Nothing is quite as devastating as the unexpected loss of a child, especially when the death occurs so unexpectedly and in someone who appeared to be so healthy. (ghs.org)
  • Death typically occurs within minutes to one hour of the onset of symptoms. (ghs.org)
  • Sudden cardiac death occurs in diabetic patients who have autonomic neuropathy, but the cause is uncertain. (nih.gov)
  • Without immediate medical treatment, death occurs within minutes. (fsu.edu)
  • Sudden death is generally defined as a death that occurs within one hour of the patient having symptoms, such as chest pain or difficult breathing. (innovations-report.com)
  • Saint Peter's Healthcare System's Helmets for Hearts'' weekend is timed to coincide with Sudden Cardiac Arrest Awareness Month, held every October to publicize, in part, the dangers of HCM, which occurs in one in 500 people, or more than 600,000 people in the United States. (njtoday.net)
  • However, more alarming is that fact that most sudden-death heart attacks occur among people with no known risk factors. (lewrockwell.com)
  • Cleveland Clinic ] The majority of sudden-death heart attacks occur in lower-risk populations! (lewrockwell.com)
  • Sudden-death heart attacks often occur while exercising and sweating away important electrolyte minerals, particularly magnesium. (lewrockwell.com)
  • Of the more than 350,000 cardiac arrests estimated to occur outside of hospitals in the United States every year, nearly 90 percent result in death. (medicalnewstoday.com)
  • This equates to around 10% of all Australian deaths that occur every year (153,000). (heartfoundation.org.au)
  • About a third of sudden cardiac deaths occur without any warning at all. (heartfoundation.org.au)
  • Those with cardiovascular disease are at greater risk for sudden cardiac death, which can occur during or after a heart attack. (memorialcare.org)
  • Sudden cardiac death can occur without signs or symptoms. (memorialcare.org)
  • Without immediate treatment, death can occur within minutes. (memorialcare.org)
  • Sudden cardiac death can occur when someone in sudden cardiac arrest is not treated promptly. (heart.org)
  • Sudden cardiac arrest can occur after a heart attack, or during recovery. (heart.org)
  • Sudden cardiac death (SCD) is an event that can occur in asymptomatic individuals, as well as in those with advanced cardiovascular (CV) disease. (uspharmacist.com)
  • Sudden cardiac death is the most common mode of death in this country with more than 300,000 deaths per year, a third of which occur during physical activity. (sun-sentinel.com)
  • Although such deaths are relatively rare, they usually occur unexpectedly among people who appear quite healthy. (scienceblog.com)
  • When these sudden deaths occur, it's often during physical activity, such as playing a sport. (prlog.org)
  • But with sudden cardiac death, the majority (of cases) occur in the general population. (reuters.com)
  • Every year, 50-100 sudden cardiac deaths occur per 1,000 deaths in Europe and North America. (biotronik.com)
  • The American Heart Association estimates that nearly 300,000 such cardiac arrests occur in the United States each year. (winespectator.com)
  • About 25 percent of these deaths will occur during sports participation. (ghs.org)
  • Approximately 30% of sudden cardiac deaths seem to occur at night. (healthjockey.com)
  • Abnormalities in this system occur in relatively rare genetic diseases such as Long QT syndrome, Brugada syndrome, and Catecholaminergic polymorphic ventricular tachycardia, all associated with sudden death. (wikipedia.org)
  • Cardiac arrhythmias can occur as a result of the changes in the heart muscle. (healthcanal.com)
  • The area composita is a structure specifically modified to the heart, where extra strong connections between cardiac muscle cells occur. (healthcanal.com)
  • Fortunately, there are some predictors for sudden cardiac death (SCD), as it tends to occur in families. (seattlechildrens.org)
  • The majority of the inherited cardiac diseases causing sudden death express themselves at variable ages in the form of altered muscle function - for instance hypertrophic or dilated cardiomyopathy - or in the form of arrhythmias, including Brugada syndrome and long QT syndrome. (springer.com)
  • Findings were drawn from tracking death and hospitalization of 101 consecutive patients with dilated cardiomyopathy. (diagnosticimaging.com)
  • Prior clinical studies have suggested that an individual's genes may contribute to the risk of cardiac arrhythmias and sudden cardiac death. (eurekalert.org)
  • Despite or perhaps because of these changes, hibernating animals have been found to be more resistant to cardiac arrhythmias and sudden cardiac death. (medicalxpress.com)
  • Ventricular arrhythmias and sudden death are responsible for hundreds of thousands of deaths each year throughout the world. (wiley.com)
  • Ventricular Arrhythmias and Sudden Cardiac Death provides the information that cardiologists, cardiac electrophysiologists, cardiac electrophysiology fellows, scientists, industry, and associated professionals need to know about current and evolving Ventricular Tachyarrhythmia treatment and diagnosis. (wiley.com)
  • Blacks are disproportionally affected by heart failure , arrhythmias, and sudden cardiac death but are vastly underrepresented in the majority of clinical trials conducted to date," said Albert Y. Sun, MD, lead author of the study published in Circulation: Cardiovascular Genetics . (healthcanal.com)
  • The Working Group consisted of experts in pediatric and adult cardiology, emergency care medicine, cardiac electrophysiology, neurology, and pathology as well as in epidemiology, biostatistics, and the establishment and use of cardiac arrest registries. (nih.gov)
  • Our current understanding of the mechanisms responsible for SCD has emerged from decades of basic science investigation into the normal electrophysiology of the heart, the molecular physiology of cardiac ion channels, fundamental cellular and tissue events associated with cardiac arrhythmias, and the molecular genetics of monogenic disorders of heart rhythm. (jci.org)
  • Chugh holds the Pauline and Harold Price Endowed Chair in Cardiac Electrophysiology at the Cedars-Sinai Heart Institute. (medpagetoday.com)
  • This issue of Cardiac Electrophysiology Clinics, edited by Drs. Mohammad Shenasa, N. A. Mark Estes III, and Gordon F. Tomaselli, will cover Contemporary Challenges in Sudden Cardiac Death. (elsevier.com)
  • This is a condition striking otherwise healthy people, who have experienced no obvious symptoms of heart disease prior to their deaths. (rense.com)
  • Sudden cardiac death describes the unexpected natural death from a cardiac cause within a short time period, generally ≤1 hour from the onset of symptoms, in a person without any prior condition that would appear fatal. (ahajournals.org)
  • 2 hours from the onset of symptoms, 12% of all natural deaths were classified as sudden in one study, and 88% of those were due to cardiac disease. (ahajournals.org)
  • The term sudden cardiac death refers to natural death from cardiac causes, heralded by abrupt loss of consciousness within one hour of the onset of acute symptoms. (news-medical.net)
  • Heart attack warning signs aren't always what you think - symptoms are not always sudden or severe and some people don't experience chest pain at all. (heartfoundation.org.au)
  • The arrest should have occurred within 24 hours after onset of any symptoms that could retrospectively be interpreted as being of cardiac origin. (ahajournals.org)
  • In general, SCD is defined as unexpected death occurring within a specific time frame after initial onset of cardiac symptoms. (uspharmacist.com)
  • What are the symptoms of sudden cardiac arrest? (clevelandclinic.org)
  • Indeed, about 90% of sudden deaths, defined as death occurring within one hour of the onset of symptoms, are found to be caused by cardiac structural pathology in autopsy-based series. (mja.com.au)
  • Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. (harvard.edu)
  • The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (harvard.edu)
  • Some researchers utilise the World Health Organisation (WHO) definition of death occurring within 24 hours of the onset of acute 'cardiac' symptoms, whilst others utilise the Framingham Heart Study cut-off of death due to cardiovascular collapse less than 1 hour from the onset of symptoms. (forensicmed.co.uk)
  • Some of the syndromes may be inherited, and symptoms including syncope , cardiac arrest, palpitations , dizziness and atrial fibrillation may be found amongst surviving family members. (forensicmed.co.uk)
  • The research defined "sudden death" as death or collapse that occurred within an hour after the onset of symptoms, a witnessed cardiac arrest, or both. (naturalnews.com)
  • The far majority of children who suffer from sudden cardiac events and sudden cardiac death have no symptoms prior so comprehensive cardiac screening can improve protection for all children. (seattlechildrens.org)
  • and the implementation of this action step has resulted in thousands of parents being asked about family history of SCDY, as well as assessing the student athlete's personal history of cardiac symptoms. (cdc.gov)
  • High blood sugar levels can cause small blood vessel disease without visible symptoms, possibly leading to a greater risk of sudden cardiac death as well. (newsinferno.com)
  • OBJECTIVES: To study the incidence, pathogenesis and symptoms preceding sudden cardiovascular death amongst 15-35-year olds without substance abuse in Sweden during 1992-99. (diva-portal.org)
  • Because premortal cardiac-related symptoms are relatively common and treatment methods are developing, we should learn to recognize early symptoms of heart disease. (diva-portal.org)
  • Possibly cardiac-related alpitations were common, but also non-specific symptoms such as fatigue after an influenza- like illness. (diva-portal.org)
  • Symptoms preceding sudden cardiac death in the young are common but often misinterpreted. (diva-portal.org)
  • CONCLUSIONS: The patient seeking medical advice before suffering an SCD is characterized by one to three of the following: 1) cardiac-related symptoms or non-specific symptoms often after an infectious disease, 2) a pathological ECG, 3) a family history of SCD. (diva-portal.org)
  • From the reviews: "This is a comprehensive review of the sudden cardiac death syndrome. (springer.com)
  • clinically relevant resource on sudden cardiac death syndrome, an area currently suffering from a paucity of scientific evidence. (springer.com)
  • Sudden infant death syndrome is the sudden, unexpected and unexplained death of an apparently healthy baby. (bartleby.com)
  • Sudden Infant Death Syndrome Sudden infant death syndrome (SIDS) is the most frequent cause of death between 1 month and 1 year of age (Naeye). (bartleby.com)
  • Sudden infant death syndrome (SIDS) is the unexpected, sudden death of a child under age 1 in which an autopsy does not show an explainable cause of death. (bartleby.com)
  • Virtual human hearts beating on supercomputers are helping get to the bottom of the most mysterious of heart diseases - sudden arrhythmic death syndrome. (newscientist.com)
  • If a post-mortem doesn't find one, sudden arrhythmic death syndrome (SADS) is recorded as the cause. (newscientist.com)
  • The abrupt cessation of effective cardiac function due to an aberrant heart rhythm can cause sudden and unexpected death at any age, a syndrome called sudden cardiac death (SCD). (jci.org)
  • The sudden infant death syndrome (SIDS) causes the sudden death of an apparently healthy infant, which remains unexplained despite a thorough investigation, including the performance of a complete autopsy. (hindawi.com)
  • The Brugada syndrome is an inherited channelopathy that alters the main transmembrane ion currents that constitute the cardiac action potential. (medworm.com)
  • This syndrome is responsible for nearly 20% of all sudden cardiac deaths in patients with structurally normal hearts and up to 12% of all sudden cardiac deaths. (medworm.com)
  • The remaining 10% relate to other cardiac electrical disorders, such as long-QT syndrome and Wolf-Parkinson-White syndrome, or commotio cordis (the result of sudden sharp chest blows), as well as complications of asthma, substance misuse, and sudden infant death syndrome (SIDS). (mja.com.au)
  • While a number of genes have been linked with arrhythmias, UC Irvine's Geoffrey Abbott and his colleagues discovered that the functional impairment of a gene called KCNE2 underlies a multisystem syndrome that affects both heart rhythm and blood flow and can activate chemical triggers that can cause sudden cardiac death. (news-medical.net)
  • Our discovery that a single gene disruption can give rise to a multitissue syndrome that predisposes one to sudden cardiac death challenges the established thinking that this type of genetic disruption can only give rise to a single component, such as abnormal electrical signaling in cardiac cells,' Abbott said. (news-medical.net)
  • A new study from Brown University, Providence has revealed that individuals with long QT syndrome (LQTS) are at an increased risk of sudden death due to irregular heartbeats, also known as a cardiac arrhythmias. (medindia.net)
  • Long QT syndrome is a rare congenital heart condition characterized by prolonged QT intervals and can cause sudden cardiac deaths. (medindia.net)
  • New Zealand researchers say they have devised a new way to identify genetic mutations behind a syndrome that leads to sudden cardiac death. (medindia.net)
  • The Long QT syndrome is a rare yet almost fatal, heart rhythm disorder occurring right from birth and it causes recurrent collapse and sudden death. (medindia.net)
  • The term Sudden Adult Death Syndrome (SADS) has been proposed for these deaths (Bowker et al 2003, Davies 1992). (forensicmed.co.uk)
  • In the new study, researchers tested whether a gene variant previously linked to sudden infant death syndrome and other heart rhythm conditions was associated with arrhythmias in blacks with heart failure and a diminished heart function called reduced ejection fraction. (healthcanal.com)
  • Currently available genetic screening tests for long QT syndrome (an inherited disorder that causes recurrent collapse and sudden death) miss about a third of cases. (sciencemediacentre.co.nz)
  • Although Marfan syndrome and resulting aortic dissection have most commonly occurred in male basketball players, it could account for a small fraction of the deaths in this population. (acc.org)
  • The estimate of cardiac arrest includes not just heart disease-related deaths, but also those from drowning and other trauma as well as those due to sudden infant death syndrome and those related to respiratory causes. (everydayhealth.com)
  • It's exciting that these authors opened up a new [biological] network [to investigate] for families who have lost a child unexpectedly or a young adult unexpectedly," said Debra Weese-Mayer , who studies sudden infant death syndrome (SIDS) at Lurie Children's Hospital in Chicago. (the-scientist.com)
  • Cardiac Risk in the Young (CRY) is a humanitarian charitable organisation helping to raise awareness of young sudden cardiac death (YSCD, SCD), including sudden arrhythmic death syndrome (SADS, SDS). (wikipedia.org)
  • So person A can have the mutation [but his ECG shows] he's absolutely normal, so you don't need to do the complex surgery to prevent sudden cardiac death. (newscientist.com)
  • The National Heart, Lung, and Blood Institute (NHLBI) convened a Working Group meeting on May 20, 2016 in Bethesda, MD to identify research barriers and outline possible solutions to prevent sudden cardiac death (SCD) in the general population with the establishment of short and long-term goals. (nih.gov)
  • A wearable defibrillator can prevent sudden death in people with dangerous heart arrhythmias, according to research presented at the American Heart Association's Scientific Sessions 2011. (medicalxpress.com)
  • As part of a significant research endeavour to prevent sudden cardiac death in young New Zealanders, funded by Cure Kids, the research study analysed the DNA of 26 patients with LQTS identified by the Cardiac Inherited Disease Group who had tested negative for LQTS gene mutations. (medindia.net)
  • As researchers look to develop better drugs, the implantable cardiac defibrillator, a device that can prevent sudden death in patients at risk for ventricular fibrillation, has already helped thousands of people. (harvard.edu)
  • The primary mission of Sport Cardiology is to prevent Sudden Cardiac Death(SCD) during exertion. (texasheart.org)
  • Can we prevent sudden death? (eventbrite.co.uk)
  • 14:10 Can ablation prevent sudden death? (eventbrite.co.uk)
  • Ghanshyam Patel, EMPL ID: 23591518 CHSS Research Paper Instructor: Dr. Christian Grov SUDDEN CARDIAC DEATH Author: Ghanshyam Patel MBBS, MPH EMPL Id: 23591518, [email protected] FROM, CUNY Graduate School of Public Health and Health Policy, 55 West 125th Street, New York, NY 10027, USA Abstract: Sudden cardiac death (SCD) is major public health problem. (bartleby.com)
  • ABSTRACT: Sudden cardiac death (SCD) has been associated with diabetes, although it is unclear whether diabetes is a risk factor for SCD. (uspharmacist.com)
  • regard to sudden unexpected mortal heart attacks. (lewrockwell.com)
  • Modern medicine distracts with the false notion that the availability of cardiac defibrillators will meaningfully save lives, but very few people (3-6%) survive these "electrical malfunction" heart attacks that throw the heart's main blood pumping chambers into a mortal spasm. (lewrockwell.com)
  • Sudden-death hearts attacks, defined as death within 1-hour of a sudden heart seizure, kills 325,000 Americans a year, or 890 every day or 37 people ever hour. (lewrockwell.com)
  • This type of heart attack represents more than half of all heart disease deaths. (lewrockwell.com)
  • The total number of people who succumb to these unexpected sudden-death heart attacks is roughly equivalent to the number of people who die from breast cancer, cervical cancer, diabetes and house fires combined. (lewrockwell.com)
  • Technically sudden cardiac arrest is not a heart attack, known in medical lingo as a myocardial infarction, where an artery that carries oxygenated blood to heart muscle becomes blocked due to clots, constriction or collapse of the artery wall itself. (lewrockwell.com)
  • Cardiac arrest is where the pumping chambers of the heart flutter or fibrillate. (lewrockwell.com)
  • While the numbers of sudden-mortal heart attacks are in the hundreds of thousands, fortunately the overall incidence is only 1/10th of one-percent per year. (lewrockwell.com)
  • In less-developed countries, sudden cardiac death rates parallel the rates of ischemic heart disease as a whole and therefore are lower. (ahajournals.org)
  • The present risk factors (see below) generally identify the risk of developing the structural heart disease underlying sudden cardiac death rather than the proximate precipitator of the event. (ahajournals.org)
  • Because the risk of sudden cardiac death does not necessarily equate with the risk of developing structural heart disease, these risk factors have limited ability in identifying specific individuals at risk for sudden cardiac death. (ahajournals.org)
  • This simple heart test takes only a few minutes, and can mean the difference between life and death. (chicagotribune.com)
  • If a young athlete does suffer a sudden heart attack, call 911 immediately and use an automatic external defibrillator (AED) to keep the child's heart beating until help arrives. (chicagotribune.com)
  • A protein has been shown to have a surprising role in regulating the 'glue' that holds heart cells together, a finding that may explain how a gene defect could cause sudden cardiac death. (ox.ac.uk)
  • Further studies of heart tissue from human patients who had died from ARVC showed that some of them have similar defects in desmosomes as in the mice suggesting that the faulty iASPP gene could also be responsible for ARVC deaths in humans. (ox.ac.uk)
  • Johns Hopkins researchers report that the level, or "copy number," of mitochondrial DNA--genetic information stored not in a cell's nucleus but in the body's energy-creating mitochondria--is a novel and distinct biomarker that is able to predict the risk of heart attacks and sudden cardiac deaths a decade or more before they happen. (news-medical.net)
  • Sudden cardiac arrest is not the same as heart attack, which is a condition that arises when the blood supply that nourishes the heart is suddenly blocked - often because of a blood clot. (medicalnewstoday.com)
  • A helpful way to distinguish the two conditions is to see sudden cardiac arrest as an "electrical" fault, and heart attack as a "circulation" fault. (medicalnewstoday.com)
  • SADS can result from a number of genetic conditions that affect the way electrical signals pass through the cardiac muscle making the heart beat. (newscientist.com)
  • Sudden cardiac death rates have not declined in Australia at the same rate as other heart related deaths. (heartfoundation.org.au)
  • Prompt response to chest pain may avert cardiac arrest and sudden cardiac death in people suffering a heart attack. (heartfoundation.org.au)
  • It's important everyone has an awareness of their family history of heart death or heart attack at a younger age. (heartfoundation.org.au)
  • Young baseball and softball players who receive direct ball impact to the chest wall directly over the heart may develop sudden cardiac arrest, a condition called commotio cordis. (momsteam.com)
  • To be clear, sudden cardiac death is not synonymous with a heart attack. (healthcentral.com)
  • Sudden cardiac death or arrest is the result of sudden, defective electrical activity in the heart, often with little warning. (healthcentral.com)
  • Primary electrical diseases of the heart, which may cause lethal arrhythmias as a result of dysfunctioning cardiac ion channels ("cardiac ion channelopathies") and are not detectable during a standard postmortem examination, may create the vulnerable infant and thus contribute to SIDS. (hindawi.com)
  • While the terms "sudden cardiac arrest" and "heart attack" are often used as if they are synonyms, they aren't. (heart.org)
  • Heart attacks increase the risk for sudden cardiac arrest, but most heart attacks do not lead to sudden cardiac arrest. (heart.org)
  • Sudden cardiac death accounted for 41% to 50% of years of potential life lost due to heart disease , the leading cause of death for both men and women, according to Sumeet Chugh, MD , of the Cedars-Sinai Heart Institute in Los Angeles, and colleagues. (medpagetoday.com)
  • For men, the top causes of death were heart disease (including sudden cardiac death) and cancer, which occurred at rates of 205 and 197 per 100,000, respectively. (medpagetoday.com)
  • Heart disease and cancer also topped the list of causes of death for women, occurring at rates of 188 and 174 per 100,000, respectively. (medpagetoday.com)
  • Sudden cardiac death was associated with 2.04 million years of potential life lost in men and 1.29 million years in women, representing 50% and 41%, respectively, of the years lost due to deaths from overall heart disease (4.11 million for men and 3.11 million for women). (medpagetoday.com)
  • Sudden cardiac death (SCD) is a sudden, unexpected death caused by loss of heart function (sudden cardiac arrest). (clevelandclinic.org)
  • Sudden cardiac death is responsible for half of all heart disease deaths. (clevelandclinic.org)
  • How is sudden cardiac arrest (AV) Node different from a heart attack? (clevelandclinic.org)
  • Sudden cardiac arrest is not a heart attack (myocardial infarction). (clevelandclinic.org)
  • Most sudden cardiac deaths are caused by abnormal heart rhythms called arrhythmias. (clevelandclinic.org)
  • Patients with heart failure are 6 to 9 times more likely than the general population to experience ventricular arrhythmias that can lead to sudden cardiac arrest. (clevelandclinic.org)
  • This is the first time a gene has been identified using ICD monitoring and then confirmed to be associated with sudden cardiac death in the general population," said principal investigator Professor Heiner Wieneke, chief physician in the Department of Cardiology, Contilia Heart and Vessel Centre, St. Marien-Hospital Mülheim, Germany. (eurekalert.org)
  • Sudden cardiac arrest (SCA) is a condition in which the heart suddenly stops beating. (medlineplus.gov)
  • Primary prevention of sudden cardiac death (SCD) with an implantable cardioverter-defibrillator (ICD) now is a key element of clinical care in adults with heart failure with reduced ejection fraction (HFrEF). (bmj.com)
  • In addition, these patients had an increased risk of death due to progressive heart failure (HR 1.6, 95% CI 1.1 to 2.3) or to non-cardiovascular causes (HR 1.5, 95% CI 1.1 to 2.2). (bmj.com)
  • Another approach to prevention of sudden cardiac death, particularly in people without a previous history of heart disease, is widespread training in cardiopulmonary resuscitation and public access to automated external defibrillators (AEDs). (bmj.com)
  • The two studies, one on cardiovascular disease published in JAMA Cardiology on Oct. 11 and the other focused on sudden cardiac death and published in the European Heart Journal on June 30, revealed that including the mitochondrial DNA copy number improved the accuracy of currently used clinical measures for a patient's risk of a deadly cardiac event. (eurekalert.org)
  • The calculator, currently considered the gold standard for predicting heart disease risk, takes into account a patient's total cholesterol, blood pressure, family history, smoking history, weight and other factors to predict a 10-year risk of suffering a life-threatening cardiac event. (eurekalert.org)
  • In addition to improving the predictive value of the Heart Risk Calculator, the second study adds evidence that the mitochondrial DNA copy number also appears to be predictive of sudden cardiac death. (eurekalert.org)
  • The team uses advanced imaging techniques, including echocardiography, cardiac MRI and 3-D imaging, to help determine the right approach, resulting in some of the best pediatric heart surgery outcomes in the nation. (prlog.org)
  • Each of the different factors -- a Mediterranean-style diet, a healthy weight, not smoking and exercise -- were linked to a smaller chance of sudden cardiac death, which is related to a malfunctioning of the electrical rhythm of the heart, the study in the Journal of the American Medical Association said. (reuters.com)
  • The study, funded by the National Institutes of Health and the American Heart Association, did not look at how long women stuck to each of the healthier lifestyle factors, nor was it able to prove that healthy living is actually responsible for the drop in sudden cardiac death risk. (reuters.com)
  • Dr. Nathaniel Reichek of St. Francis Hospital in Roslyn, NY, has shown that CMR produces more measures of ejection fraction, volume, and masses than echocardiography, the first-line instrument of choice for many heart conditions that cause sudden mortality. (diagnosticimaging.com)
  • Sudden cardiac death (SCD) is the medical term for an unexpected death caused by loss of heart function. (biotronik.com)
  • A heart attack , other cardiac arrhythmias , heart valvular diseases or diseases of the heart's muscle (cardiomyopathy or myocarditis) may cause SCD. (biotronik.com)
  • Women who drink in moderation face a significantly lower risk of sudden cardiac death than nondrinkers, according to an October study in Heart Rhythm . (winespectator.com)
  • Sudden cardiac death is not the same as a heart attack. (winespectator.com)
  • That can weaken the heart, keeping it from pumping blood effectively, and can eventually trigger cardiac arrest and possible death. (winespectator.com)
  • The study authors say prior cardiovascular research focused mainly on men and mainly on heart attacks-rarely on sudden cardiac death. (winespectator.com)
  • Abbott said the major breakthrough in this study is that KCNE2 deletion could adversely affect so many other tissues outside the heart and that this dramatically worsened the outcome of cardiac electrical disturbances. (news-medical.net)
  • A new predictor may help save lives from sudden cardiac death, according to a study released from the American Heart Association's journal, Circulation . (seton.net)
  • During sudden cardiac death, a person's normal electrical rhythm malfunctions and causes the heart to stop beating. (seton.net)
  • Cardiac catheterization is a radiological procedure for both diagnosis and treatment of heart conditions. (medindia.net)
  • Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. (medicalxpress.com)
  • To date there has been no study evaluating the age of onset of heart involvement, the type of heart involvement, the rate of heart disease progression and the risk of sudden cardiac death in children affected with LMNA-MD. The investigators' research aims to evaluate heart involvement in children and teens affected by LMNA-MD. (clinicaltrials.gov)
  • With certain triggers, like exercise or emotional stress, these mutations may cause an otherwise structurally-normal heart to undergo rhythmic changes which may lead to fainting, epileptic-like seizures and even sudden death. (medindia.net)
  • Warnings signs for heart attacks and sudden cardiac arrest can go undiagnosed. (eveningsun.com)
  • Sudden cardiac arrest is the abrupt loss of heart function, breathing and consciousness, according to the Mayo Clinic . (eveningsun.com)
  • Cristina Basso from Padua emphasized that the heart may be normal in up to 20% of cardiac SD cases. (escardio.org)
  • In 30 patients with insulin-dependent diabetes mellitus who had no evidence of ischemic heart disease, cardiac autonomic neuropathy, determined by clinical tests, was found in 17. (nih.gov)
  • Over the course of 2 years, we will investigate our hypothesis that genetic heart disease is associated with autopsy-negative sudden death in TB racehorses. (cornell.edu)
  • Sudden cardiac arrest, a condition wherein the heart unexpectedly stops beating seems to be fatal in many cases. (healthjockey.com)
  • Since the heart rate appears to slow down immensely at night, an individual may suffer from a sudden cardiac arrest at night. (healthjockey.com)
  • This can probably adjust cardiac function further causing heart arrest. (healthjockey.com)
  • In England, the rate of sudden unexpected adult deaths due to ischaemic heart disease is estimated to be 9.1 per 100,000 per annum. (forensicmed.co.uk)
  • There is some awful irony in that exercise, a known health benefit for the heart, leads to cell death in ACM subjects," Chelko said. (fsu.edu)
  • Now, we know that endurance exercise, in particular, leads to large-scale myocyte cell death due to mitochondrial dysfunction in those who suffer from this inherited heart disease. (fsu.edu)
  • Natural News ) Heart disease remains among the world's top killers, causing one in every four deaths in the U.S. alone . (naturalnews.com)
  • The study examined the risk of sudden death caused by a heart attack among male U.S. doctors. (naturalnews.com)
  • According to the American Heart Association, about 250,000 Americans suffer sudden cardiac death each year, and half of them may have no prior warning. (innovations-report.com)
  • And, in 5 to 10 percent of all cases, these sudden cardiac deaths remain unexplained since the heart may have no visible abnormality. (innovations-report.com)
  • In an effort to explore if defects in genes cause these mysterious deaths, Oregon Health & Science University heart researchers studied five genes already known to increase a person s risk for sudden cardiac death. (innovations-report.com)
  • They looked for mutations in five genes that are already linked to two diseases in the heart s electrical systems known to cause sudden death, the long QT and Brugada syndromes. (innovations-report.com)
  • Chugh s discovery takes one giant step toward predicting who is vulnerable for dying suddenly and it brings hope that we may some day prevent the form of cardiac death that comes without warning," said Kent Thornburg, Ph.D., director of the OHSU Heart Research Center and professor of medicine (cardiology) in the OHSU School of Medicine. (innovations-report.com)
  • The Oregon Sudden Unexplained Death Study (Ore-SUDS) will be the first genome bank and data base to provide researchers with more comprehensive data about the deceased patient s heart at the time of death. (innovations-report.com)
  • Inquire is there is any heart disease, any history of seizures, or unexplained or sudden death. (seattlechildrens.org)
  • Ventricular arrhythmias, or abnormal heart rhythms, are the most common cause of sudden cardiac death: the primary cause of death from heart disease. (medicalxpress.com)
  • For example, knowing that KLF15 levels are reduced in heart failure patients, medications that increase KLF15 levels, particularly at certain times of the day when sudden death is more common, could reduce the incidence of this fatal disorder. (medicalxpress.com)
  • This it is the first time a definitive link between circadian rhythms and sudden cardiac death has been established," said Mukesh K. Jain, MD, FAHA, professor of medicine, Ellery Sedgwick Jr. Chair, and director, Case Cardiovascular Research Institute at Case Western Reserve University School of Medicine and the chief research officer, Harrington Heart & Vascular Institute at University Hospitals Case Medical Center. (medicalxpress.com)
  • In particular, such therapies could be beneficial for patients with heart failure or hereditary mutations where nocturnal death is common. (medicalxpress.com)
  • It begins with a definition and introduction to sudden death and its causes, which are mainly ischaemic heart disease, cardiomyopathy and the newly-observed channelopathies predominating in the younger age group. (bjcardio.co.uk)
  • Primary prevention of sudden death is highlighted with controversy over its widespread application, particularly in ischaemic heart disease patients with poor left ventricular function, which is the main risk factor for sudden death in this group of patients. (bjcardio.co.uk)
  • The issue of sudden death in heart failure is great due to the application of ICDs and their cost in the general population. (bjcardio.co.uk)
  • Overall, this is an excellent book of great use to cardiologists, particularly those who have an interest in sudden death, inherited cardiac disease and ischaemic heart disease. (bjcardio.co.uk)
  • Wes was later declared dead at a local hospital and the autopsy showed that he died of cardiac arrest due to an enlarged heart. (cdc.gov)
  • The second section is called "Heart Health Questions About Your Family" and includes questions on family history of hypertrophic cardiomyopathy, long QT, heart problems, pacemaker, unexplained fainting, early death from a cardiac cause, and more. (cdc.gov)
  • According to a new study published in the European Heart Journal, diabetes is a serious risk factor for sudden cardiac death with the danger escalating as the diabetes becomes more severe. (newsinferno.com)
  • This information indicates that the relationship between diabetes and sudden cardiac death may involve heart disease, atherosclerosis, or a combination of the two. (newsinferno.com)
  • Sun said ICDs can effectively reduce sudden cardiac death in heart failure patients, but current evidence to guide physicians when deciding which patients may derive the most benefit is limited to only a few clinical variables. (healthcanal.com)
  • Risk analysis should include an assessment of the risk of sudden cardiac death to entrants in mass participation events such as the London marathon and the London to Brighton annual British Heart Foundation cycle ride. (bmj.com)
  • If you have a family history of SCD or a sudden death from heart disease prior to age 50, or if your child has ever passed out/blacked out during exercise or complains about chest pain with sports, talk with your child's physician prior to any athletic endeavor. (seattlechildrens.org)
  • If any concerns about heart murmurs, history of fainting with exercise, family history of cardiac or unexplained death, high blood pressure, or complaints of chest pain during and with exertion or sports - go see the doctor. (seattlechildrens.org)
  • Accordingly, author present their experience with autopsies of unexplained sudden death young victims in which a cardiac origin was suspected and the relevance of a standardized protocol for heart examination and histological sampling, as well as for toxicology and molecular investigation. (springer.com)
  • It is well described that high intensity training exercise can lead to an increased cardiac output and enlargement of the heart chambers. (acc.org)
  • He has a heart muscle disease (cardiomyopathy) that puts him at high risk of sudden cardiac death (SCD), especially when participating in endurance sports. (newstatesman.com)
  • There are increasing calls made by some doctors, bereaved families and charities such as Cardiac Risk in the Young for the screening of asymptomatic young people for underlying heart conditions. (newstatesman.com)
  • They all had an electrical recording of the heart (ECG) and a cardiac ultrasound scan (echocardiogram). (newstatesman.com)
  • Here, we review the basics of NAD + homeostasis, the molecular physiology and new advances in ischemic-reperfusion injury, heart failure, and arrhythmias, all of which are associated with increased risks for sudden cardiac death. (frontiersin.org)
  • Nearly 6,000 U.S. children experience cardiac arrest - an abrupt loss of heart function - each year, according to the American Heart Association. (everydayhealth.com)
  • Hypertrophic cardiomyopathy can interfere with one or both of these critical functions of the heart and lead to sudden cardiac death. (howardluksmd.com)
  • Sudden cardiac arrest usually is due to extremely fast heart rates. (howardluksmd.com)
  • A cardiac echo is an ultrasound that shows the heart. (howardluksmd.com)
  • In addition to these, there might be abnormal electrical circuits in the heart present at birth, abnormal heart arteries which could get compressed during exercise, and sudden traumatic impacts to the chest - the latter a more obvious cause to the spectator watching the action. (howardluksmd.com)
  • Drugs prescribed for everyday ailments could be causing thousands of sudden heart attack deaths each year, reported seven newspapers (11 May 2005). (newmediaexplorer.org)
  • The reports were based on a large observational study investigating the use of medications, known to affect heart rhythm, by people who suffered a sudden cardiac death. (newmediaexplorer.org)
  • Seven newspapers (1-7) reported that seven common drugs, including antibiotics and medications for mental illness and stomach problems could be causing up to 15,000 sudden deaths from heart attacks each year in Europe and the US. (newmediaexplorer.org)
  • It's not clear how that ultimately leads to cardiac arrest, but the researchers noted that they suspect the heart becomes poisoned by inorganic pyrophosphate. (the-scientist.com)
  • The charity supports the families of victims of YSCD, facilitates the heart screening of young people through cardiac testing programmes and contributes to medical research. (wikipedia.org)
  • Sudden cardiac death is rare in children and adolescents but accounts for 19% to 30% of sudden deaths until 21 years of age. (biomedsearch.com)
  • Sudden death in children and adolescents, with emphasis on cardiomyopathies and channelopathies, is highlighted. (bjcardio.co.uk)
  • There were 288 cases of sudden cardiac death among the 84,888 women who completed the 1980 questionnaire. (scienceblog.com)
  • But the researchers did conclude that 81 percent of cases of sudden cardiac death were due to unhealthy lifestyles. (reuters.com)
  • This compared 775 cases of sudden cardiac death with 6,297 matched controls, with respect to the use of seven drugs (two antibiotics, two stomach and three antipsychotic medications). (newmediaexplorer.org)
  • There were 775 cases of sudden cardiac death and these were matched with 6,297 controls for age, gender and GP practice. (newmediaexplorer.org)
  • Use of these drugs, based on prescription details, was compared between cases of sudden cardiac death and the matched controls. (newmediaexplorer.org)
  • In contrast, although ≈33% of patients in the convalescent phase after a large myocardial infarction experience sudden cardiac death in the year thereafter, overall they account for a small number of the total sudden cardiac deaths per year. (ahajournals.org)
  • They are two to four times more likely to experience sudden cardiac death (SCD) than the overall population. (biotronik.com)
  • The researchers found that women who consume one to two alcoholic beverages daily were 46 to 42 percent less likely, respectively, to experience sudden cardiac death than abstainers. (winespectator.com)
  • Those with borderline diabetes were 24% more likely to experience sudden cardiac death than people without diabetes. (newsinferno.com)
  • While treatment guidelines are in place, most patients who experience sudden cardiac death fall outside of the parameters for a primary prevention ICD, a device which is designed to automatically detect and correct life-threatening arrhythmias by delivering a jolt of electricity. (healthcanal.com)
  • Of the 719,402 cardiac deaths in 1998, 74% were of the sudden-death variety. (lewrockwell.com)
  • In 1998, Congress appropriated funds to NIOSH to conduct a fire fighter initiative that resulted in the NIOSH "Fire Fighter Fatality Investigation and Prevention Program" which examines line-of-duty-deaths or on duty deaths of fire fighters to assist fire departments, fire fighters, the fire service and others to prevent similar fire fighter deaths in the future. (cdc.gov)
  • The dramatic death of Anna Loyley aged 26 in the Bath half marathon in March 1998 and the subsequent campaign of her parents has been covered in many national newspapers, as well as by American internet journalism and short pieces and letters in the British Medical Journal . (bmj.com)
  • Zipes DP, Wellens HJ (1998) Sudden cardiac death. (springer.com)
  • Fatal ventricular arrhythmias are usual common pathways in such tragic events, and underlying etiologies include cardiac ion channelopathies in majority of cases. (biomedsearch.com)
  • The leading cardiac causes include diseases of the myocardium, cardiac channelopathies, myocarditis and trauma to the chest (commotio cordis). (uio.no)
  • Approximately 10-15% of sudden unexpected infant death (SUID) cases may be due to ion channelopathies. (nih.gov)
  • Similarly, sudden unexpected death in epilepsy (SUDEP) has been documented at all ages, and several risk factors have been identified, including some cases originating with ion channelopathies. (nih.gov)
  • Consequently, autopsy-negative sudden cardiac deaths (no physical abnormalities identified) may comprise a larger part of the channelopathies than previously anticipated. (wikipedia.org)
  • In younger persons, the cause of sudden cardiac death may be elusive even after autopsy, because conditions such as inherited channelopathies or drug-induced arrhythmias that are devoid of structural abnormalities are epidemiologically relevant in this age group. (springer.com)
  • El Moheb M, Nicolas J, Khamis AM, Iskandarani G, Akl EA, Refaat M. Implantable cardiac defibrillators for people with non-ischaemic cardiomyopathy. (harvard.edu)
  • Research has shown the effectiveness of implantable cardioverter-defibrillators (ICDs) in preventing sudden cardiac death, and Medicare coverage of ICDs has expanded, but many eligible patients still do not receive them. (emaxhealth.com)
  • An interesting point made is that patients with implantable cardioverter defibrillators (ICDs) still die because the public erroneously think that ICDs will avoid the risk of sudden death and make you live forever! (bjcardio.co.uk)
  • In many cases, ventricular fibrillation precedes final cardiac failure. (biotronik.com)
  • The mode of death in ICD patients is sudden in up to one third of cases, with the most common mechanism being ventricular fibrillation treated with an appropriate shock but then followed by electromechanical dissociation. (bjcardio.co.uk)
  • Unfortunately, of all patients experiencing acute myocardial infarction (MI), usually in the form of ST-elevation MI, 25-35% will die of sudden cardiac death (SCD) before receiving medical attention, most often from ventricular fibrillation. (biomedsearch.com)
  • A person in cardiac arrest has the best chance of survival if CPR is started immediately and a 'defibrillator' is used on them as soon as possible. (heartfoundation.org.au)
  • While our understanding of this disease has increased tremendously since its first description in 1992, the primary therapeutic option remains implantation of an implantable cardioverter-defibrillator to avoid sudden cardiac death. (medworm.com)
  • London, UK - 31 Aug 2015: A gene associated with sudden cardiac death in the general population has been identified using implantable cardioverter defibrillator (ICD) monitoring in research presented for the first time at ESC Congress today.1 The research included patients from the DISCOVERY trial and Oregon-SUDS and discovered that a polymorphism in the GNAS gene predicted ventricular tachyarrhythmias and sudden cardiac death. (eurekalert.org)
  • Recently, the implantable cardioverter-defibrillator (ICD) has been promoted for prevention of sudden death in hypertrophic cardiomyopathy (HCM). (nih.gov)
  • Therefore, a single marker of high risk for sudden death may be sufficient to justify consideration for prophylactic defibrillator implantation in selected patients with HCM. (nih.gov)
  • Sudden cardiac death remains a major cause of mortality among patients with cardiomyopathy and implantable cardioverter-defibrillator therapy has been shown to improve survival in these patients. (nih.gov)
  • Primary Prevention Implantable Cardiac Defibrillator Trials: What Have We Learned? (elsevier.com)
  • Among Medicare patients, men are about 2-3 times more likely than women to receive an implantable cardioverter-defibrillator for the prevention of sudden cardiac death, according to a study in the October 3 issue of JAMA. (emaxhealth.com)
  • HIgh-school AED programs demonstrate a high survival rate for students as well as adults who suffer sudden cardiac arrest on school campuses, says a new study, which strongly recommends school-based AED programmes as an important public safety measure and an effective strategy for the prevention of sudden cardiac death during sports. (momsteam.com)
  • Part one of the study was the DISCOVERY trial, a prospective, international, multicentre study in 1 145 patients who received an ICD for primary prevention of sudden cardiac death. (eurekalert.org)
  • According to the authors, researchers at Brigham and Women's Hospital and Harvard Medical School, "Light to moderate alcohol intake may be considered part of a healthy lifestyle for overall chronic disease prevention including the prevention of sudden cardiac death. (winespectator.com)
  • Lesley H. Curtis, Ph.D., of Duke University School of Medicine, Durham, N.C., and colleagues examined the differences between men and women in the receipt of ICDs for the primary and secondary prevention of sudden cardiac death. (emaxhealth.com)
  • Researchers identified 112 blacks who received ICDs for primary prevention of sudden cardiac death and followed them for an average of two years. (healthcanal.com)
  • Effective prevention of sudden cardiac death in sport would entail the following. (bmj.com)
  • Priori SG (2015) The Task force for the Management of patients with ventricular arrhythmias and the prevention of Sudden cardiac death of the European Society of Cardiology: 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. (springer.com)
  • It also includes an in-depth review of what is currently available to assist in the diagnosis, prevention and risk stratification in sudden cardiac death. (springer.com)
  • We present a case of aborted sudden cardiac death in field, resuscitated successfully, and a clinical event in the pediatric emergency department that led to the diagnosis of the underlying rare condition. (biomedsearch.com)
  • The assessment of the family depends fundamentally on the diagnosis of the cause of sudden death. (bmj.com)
  • This session was devoted to the need to achieve a precise diagnosis of sudden death (SD) through postmortem examination. (escardio.org)
  • Brady, W. J. (2006) Chest Pain with Sudden Cardiac Death, in Visual Diagnosis in Emergency and Critical Care Medicine (eds C. P. Holstege, A. B. Baer, J. M. Pines and W. J. Brady), Blackwell Publishing Ltd, Oxford, UK. (wiley.com)
  • University of Auckland researchers have established a new way to identify gene mutations, which will directly lead to improved diagnosis of young people at risk of sudden cardiac death. (sciencemediacentre.co.nz)
  • The key in preventing and screening this population lies in the early diagnosis of individuals who may have underlying cardiac conditions, putting them at risk of cardiac arrhythmias and SCD. (acc.org)
  • In 6 out of 10 a cardiac diagnosis was not considered. (diva-portal.org)
  • This intervention limits neurologic injury associated with brain ischemia during a cardiac arrest and reperfusion injury associated with resuscitation. (medscape.com)
  • This study gathered information about people who experienced sudden cardiac death (SCD), also called sudden cardiac arrest (SCA) including: circumstances of death, resuscitation outcomes, and emergency response records, as well as clinical health records and autopsy reports. (healthcentral.com)
  • Irrespective of the underlying disease the final cause of sudden cardiac death is an abnormal rhythm. (heartfoundation.org.au)
  • Abnormal G-protein signal transduction has been suggested as a mechanism contributing to sudden cardiac death. (eurekalert.org)
  • Studies have shown the link between abnormal levels of thyroid hormone and cardiovascular disease, but they haven't established the hormone's link to sudden cardiac death. (seton.net)
  • The most common finding at autopsy is autopsy-negative sudden unexplained death. (acc.org)
  • A number of studies have demonstrated that the use of 2-dimensional echocardiogram to evaluate left wall motion abnormalities after an acute MI (using the LV wall-motion score index) is useful in predicting the risk for major cardiac events, including sudden death. (medscape.com)
  • A decrease in the ejection fraction and worsening wall motion abnormalities upon exercise echocardiography in patients who have had an MI has been suggested to confer increased risk of cardiac death. (medscape.com)
  • An effective method of preventing those at high risk from competing, without excluding everyone with trivial cardiac "abnormalities" from participating in a healthy activity. (bmj.com)
  • Nearly 350,000 people suffer cardiac arrest annually. (momsteam.com)
  • Normal-weight women were 56 percent less likely to suffer sudden cardiac death compared to obese women, while at least 30 minutes a day of exercise reducing the risk by 28 percent. (reuters.com)
  • Women who had never smoked were 75 percent less likely to suffer sudden cardiac death than women who smoked at least 25 cigarettes per day. (reuters.com)
  • Most newspapers reported that a Dutch study found that users of the drugs were nearly three times more likely to suffer a sudden cardiac death. (newmediaexplorer.org)
  • Every three days, sudden cardiac death (SCD) takes the life of a young U.S. athlete, such as a girl playing soccer, a boy at basketball practice or a high school football player. (chicagotribune.com)
  • The preliminary findings of a study from Denmark suggest that children and young adults with diabetes may have seven times the risk of sudden cardiac death of young people without it. (medicalnewstoday.com)
  • The results of a recent study suggest that young people with diabetes have a much higher likelihood of sudden cardiac death. (medicalnewstoday.com)
  • Although we have become better at helping people manage both type 1 and type 2 diabetes ," says study contributor Jesper Svane, a postgraduate medical research student at Copenhagen University Hospital, "it is still associated with increased risk of death, especially among young people. (medicalnewstoday.com)
  • SIDS is defined as the sudden death of any infant or young child that is unexpected by it's history, and in which a thorough postmortem examination fails to determine an adequate cause (Hunt 1987). (bartleby.com)
  • Any risk factor that heightens the possibility of death at a young age should warrant attention and prevention, when possible. (healthcentral.com)
  • Few events are harder to deal with than sudden death in young people. (mja.com.au)
  • When sudden cardiac death happens in a young person, it is devastating to the teen's family, friends, school and community," said Dr. Shillingford. (prlog.org)
  • Sudden cardiac arrest: How can schools prevent young athlete deaths? (eveningsun.com)
  • Hypertrophic cardiomyopathy is an important cause of sudden death in the young. (bmj.com)
  • Studies are required to use data and DNA samples from the Sudden Death in the Young Case Registry (described below) as foundations for their research. (nih.gov)
  • Sudden death in the young (SDY) is a critical public health and scientific issue. (nih.gov)
  • During the first phase, the NHLBI, NINDS and CDC created the Sudden Death in the Young (SDY) Case Registry, a surveillance system and registry that will provide the first prospective, population-based data set compiled for the comprehensive evaluation of SDY in the United States. (nih.gov)
  • Sudden cardiac death of the young (SCDY) is a devastating event for families and communities. (mdpi.com)
  • Russell, M.W. Family History of Sudden Cardiac Death of the Young: Prevalence and Associated Factors. (mdpi.com)
  • Can Sudden Cardiac Death of the Young be Prevented? (cdc.gov)
  • Although an AED was present at the school, it was not charged and CPR was not performed because people did not think that cardiac arrest could be at fault in someone so young. (cdc.gov)
  • Cardiac diseases associated with sudden cardiac death differ in young vs. older individuals. (springer.com)
  • Ackerman M, Atkins DL, Triedman JK (2016) Sudden cardiac death in the young. (springer.com)
  • Semsarian C, Sweeting J, Ackerman MJ (2004) Sudden death in young adults: a 25-year review of autopsies in military recruits. (springer.com)
  • Eckart RE, Shry EA, Burke AP et al (2011) Sudden death in young adults: an autopsy-based series of a population undergoing active surveillance. (springer.com)
  • Bagnall RD, Weintraub RG, Ingles J et al (2016) A prospective study of sudden cardiac death among children and young adults. (springer.com)
  • Puranik R, Chow CK, Duflou JA, Kilborn MJ et al (2005) Sudden death in the young. (springer.com)
  • Every week 12 young people die from sudden cardiac death. (newstatesman.com)
  • The most common cause of sudden death in the young athlete is hypertrophic cardiomyopathy or HCM. (howardluksmd.com)
  • CONCLUSION: Sudden cardiovascular death was uncommon in the young, but the incidence was not decreasing. (diva-portal.org)
  • Sudden cardiac death (SCD) in a young person is a rare but tragic event, and the potential of prevention is unknown. (diva-portal.org)
  • The day-long event aims to bring together international and UK experts in sudden death to speak upon all aspects of prevention with a focus on sudden death in the young. (eventbrite.co.uk)
  • As with the babies, both young men died because of cardiac arrest. (the-scientist.com)
  • When a young athlete suffers a sudden cardiac death (SCD), it is a rare but catastrophic event that garners attention from the media, the general public, and the medical community. (bcmj.org)
  • The charity also offers support and regular meetings to young people diagnosed with a cardiac condition through their myheart Network. (wikipedia.org)
  • Surrey, United Kingdom: Cardiac Risk in the Young. (wikipedia.org)
  • These changes not only modify the resting electrocardiogram but also predispose patients to develop malignant ventricular tachyarrhythmias that can lead to syncope, cardiac arrest, and sudden cardiac death. (medworm.com)
  • Measured risk factors for sudden death included family history of sudden death, massive left ventricular hypertrophy, nonsustained ventricular tachycardia on Holter monitoring, and unexplained prior syncope. (nih.gov)
  • Clinical Approach to Sudden Cardiac Death Syndromes details the main guidelines to clinicians on how to approach the patients and family members with an inherited disease. (springer.com)
  • The local paediatrician from Norway and Sweden and the forensic institution of Denmark invited parents of sudden infant death syndromes (SIDS) to take part in the study. (bartleby.com)
  • When someone dies suddenly and unexpectedly, there is often an underlying cardiac problem. (newscientist.com)
  • There is no national registry of sudden cardiac death, but our estimates suggest around 15,000 people die unexpectedly in Australia from sudden cardiac death every year. (heartfoundation.org.au)
  • TALLAHASSEE, Fla. - Sept. 25, 2018 - PRLog -- It happens unexpectedly - a previously healthy student athlete dies from sudden cardiac death (SCD). (prlog.org)
  • however, horses also unexpectedly die suddenly on the track (sudden death, SD). (cornell.edu)
  • ARVC is uncommon in humans, affecting around 1 in 2000 people in the UK [ 1 ], and is a leading cause of sudden cardiac death, which is estimated to kill around 100,000 people a year in the UK [ 2 ]. (ox.ac.uk)
  • Around 1.3 deaths in every 100,000 can probably be attributed to SADS , and the same genetic problems may also play a role in sudden infant deaths. (newscientist.com)
  • After adjustment for age and sex, the estimated national rate of sudden cardiac death was 60 per 100,000 people. (medpagetoday.com)
  • The rate of sudden cardiac death (per 100,000) was similar to that of cerebrovascular disease (49), chronic lower respiratory disease (46), and lung cancer (45). (medpagetoday.com)
  • Several studies have estimated the frequency of SCD in persons less than 18 years of age to be in the range of 0.8 to 6.2 deaths per 100,000 children per year. (ghs.org)
  • RESULTS: We found 181 cases of sudden cardiovascular death in a nationwide database, Rattsbase, in 15-35-year olds, of which 132 (73%) were male and 49 (27%) were female, and a rather stable incidence of 0.93 per 100,000 per year. (diva-portal.org)
  • There are few studies that include sudden cardiac arrests (SCA). (uio.no)
  • For these reasons, total mortality, rather than classifications of cardiac and arrhythmic mortality, should be used as primary objectives for many outcome studies. (ahajournals.org)
  • The death certifi cate, completed by the at- Ensure that fi re fi ghters are cleared for duty by a phy- tending physician, listed "acute myocardial infarction sician knowledgeable about the physical demands of (MI)" as the cause of death. (cdc.gov)
  • Severe arrhythmias can cause dizziness or even lead to fainting or an acute cardiac arrest (= sudden death). (healthcanal.com)
  • The clinical challenge of preventing sudden cardiac death immediately after acute ST-elevation myocardial infarction. (biomedsearch.com)
  • Genetic testing is also now available for many of these rare cardiac conditions. (heartfoundation.org.au)
  • Epidemiological studies have suggested that genetic factors contribute to sudden cardiac death but only a few genes have been identified. (eurekalert.org)
  • In the future, testing blood for this genetic information could not only help physicians more accurately predict a risk for life-threatening cardiac events, but also inform decisions to begin--or avoid--treatment with statins and other drugs. (eurekalert.org)
  • In addition, you should investigate your family history and identify anyone who experienced sudden cardiac death, since some of these conditions have a genetic basis and "run in the family. (ghs.org)
  • The ideal is for the examination to be performed by a specialist cardiac pathologist with appropriate samples being taken for histological and genetic analysis. (bmj.com)
  • The authors ascertained that a person at any age having a genetic abnormality may face a sudden cardiac arrest. (healthjockey.com)
  • Chugh s team used genetic analysis and cellular tests to determine if any of the five genes were linked to theses deaths. (innovations-report.com)
  • ICDs continuously monitor a patient's cardiac rhythm. (eurekalert.org)
  • In fact, cholesterol-lowering drugs are not deemed to be a very effective way of reducing cardiac and overall mortality in the general population. (lewrockwell.com)
  • In a classic experiment, it was found that stressing animals who were magnesium deficient resulted in an almost 100% mortality from sudden cardiac arrest. (rense.com)
  • These factors have an impact on the effects of therapeutic interventions because, although it is relatively easy to identify patients in the small high-risk subgroups and then to possibly prevent or reverse a ventricular tachyarrhythmia, the overall impact on the total number of sudden cardiac deaths will be small. (ahajournals.org)
  • In the case of patients for whom this method is not diagnostic, other methods are available including transesophageal echocardiography, cardiac magnetic resonance imaging (CMRI), and computed tomographic (CT) angiography. (nih.gov)
  • With time, the 'cracks' get bigger and when they reach a certain level it leads to premature death in adults - and these are strikingly similar to the weaknesses we see in the tissues of human ARVC patients. (ox.ac.uk)
  • The Multi-Center Post-Infarction Research Group provided evidence that resting ejection fraction was the most important noninvasive predictor of SCD and other cardiac events in patients with MI. (medscape.com)
  • Of 5831 rescue missions, 406 involved patients with presumed cardiac arrest. (ahajournals.org)
  • Using ICD monitoring and a sample of sudden cardiac death patients from the community we found that a polymorphism in the GNAS gene predicts ventricular tachyarrhythmias and sudden cardiac death," said Professor Wieneke. (eurekalert.org)
  • The findings may help to identify patients at increased risk of sudden cardiac death. (eurekalert.org)
  • Information about the heart's structure will be obtained from cardiac magnetic resonance imaging and used in combination with a number of other clinical risk factors to see if certain characteristics can better predict patients at risk for SCD. (clinicaltrials.gov)
  • People with thyroid hormone levels at the high end of the normal range were 2.5 times more likely to die of sudden cardiac death, compared to patients with levels at the lower end. (seton.net)
  • The 10-year risk of sudden cardiac death was four times greater in patients with higher thyroid levels compared to those with lower levels. (seton.net)
  • Utility of microvolt T-wave alternans to predict sudden cardiac death in patients with cardiomyopathy. (nih.gov)
  • Prolonged QTc intervals were found only in patients who had definite cardiac autonomic neuropathy. (nih.gov)
  • These data suggest that diabetic cardiac autonomic neuropathy may result in sympathetic imbalance and QTc interval prolongation, predisposing these patients to sudden arrhythmias and death. (nih.gov)
  • We analyzed the clinical data at disease onset of 17 patients with fulminant type 1 diabetes mellitus who experienced sudden death or cardiac arrest, and those of 257 patients who did not develop these conditions. (springer.com)
  • Patients with sudden death or cardiac arrest were younger, had a higher rate of impaired consciousness, more severe acidosis, hyperglycemia, hyponatremia, hyperkalemia, and hypochloremia, a higher serum blood urea nitrogen level, a higher serum creatinine level, and a higher plasma osmolality level than the other patients. (springer.com)
  • Receiver operating characteristic curve analyses showed that patients with a plasma glucose level over 1000 mg/dl (55.5 mmol/l) were at a high risk of cardiac arrest. (springer.com)
  • Among men and women alive at 30 days after entry in this group, the risk of death in the subsequent year was 35 percent lower among patients who received ICD therapy. (emaxhealth.com)
  • The patients with unexplained sudden cardiac death came from among 270 cases of sudden death that occurred between 1984 and 1996. (innovations-report.com)
  • Cases were all patients registered with a GP between January 1995 and September 2003, who had died and the cause of death was classed as sudden cardiac death. (newmediaexplorer.org)
  • The risk was also significantly higher (by nearly four times) for patients who had only been taking the drugs for less than 90 days before their death. (newmediaexplorer.org)
  • Adjusted analyses showed that the risk of sudden cardiac death in users of the drugs was higher for women than for men and also higher for older patients (aged greater than 65), but these differences were not statistically significant. (newmediaexplorer.org)
  • In a related editorial , two researchers from Cedars-Sinai Medical Center in Los Angeles said the study would have been more complete if it included patients with prior history of CVD as well as sudden cardiac arrest (SCA) that was successfully resuscitated. (cardiovascularbusiness.com)
  • OBJECTIVES: To identify patients at risk of sudden cardiac death (SCD) by analysis of clinical history. (diva-portal.org)
  • In lacrosse and other sports such as baseball and hockey, however, another unpredictable and relatively uncommon source of cardiac death has been recognized - commotio cordis. (sun-sentinel.com)
  • To date, there have been 14 cases of commotio cordis in lacrosse, including the Feb. 7 death of a 12-year-old player in upstate New York. (sun-sentinel.com)
  • Organizations such as the Louis J. Acompora Memorial Foundation and US Lacrosse have recognized the risk of sudden death and specifically commotio cordis in the sport of lacrosse. (sun-sentinel.com)
  • citation needed] Sudden cardiac death can usually be attributed to cardiovascular disease or commotio cordis, but about 20% of cases show no obvious cause and remain undiagnosed after autopsy. (wikipedia.org)
  • The researchers found that only nine of these deaths actually took place during moderate to vigorous exertion, and that only three of these happened while the women were exercising. (scienceblog.com)
  • The absolute risk of sudden cardiac death associated with moderate to vigorous exertion was "exceedingly low," the researchers found, at 1 per 36.5 million hours of exertion. (scienceblog.com)
  • After adjusting for other risk factors, the researchers determined that participants with relatively low mitochondrial DNA copy numbers were at the highest risk for sudden cardiac death. (eurekalert.org)
  • But in the studies that did focus on sudden cardiac death, men who drank light-to-moderate amounts of alcohol showed the least amount of risk, and the current researchers wanted to know if the same might be true for women. (winespectator.com)
  • Researchers say people with thyroid hormone levels at the higher end of normal range were at a significantly greater risk of dying from sudden cardiac death compared to those with levels at the lower end. (seton.net)
  • In this newest study, researchers linked the association of thyroid-stimulating hormone and free thyroxine thyroid hormone levels in blood samples with sudden cardiac deaths listed on medical records and death certificates. (seton.net)
  • Davies (1992 and 2000) and Kolodgie (2004) are amongst those researchers favouring thrombi as a common occurrence in sudden cardiac deaths. (forensicmed.co.uk)
  • After taking different related factors into account, the researchers determined that those who ate fish at least once a week had 52 percent lower risk of dying a sudden death compared to those who ate fish less than monthly. (naturalnews.com)
  • Since February 2002 Chugh has worked with a team of researchers and community agencies to collect information on every sudden unexplained death in Multnomah County, Oregon. (innovations-report.com)
  • Researchers looked at individuals enrolled in the Group Health Cooperative of Puget Sound to determine the link between blood sugar level, diabetes, and the increased risk of sudden cardiac death. (newsinferno.com)
  • Reporting in American Journal of Human Genetics today (August 11), the researchers independently pinpointed the cause of the kids' deaths to inherited mutations in a single gene, PPA2, which codes for a mitochondrial enzyme. (the-scientist.com)
  • Dr. Raymond Kwong of Brigham and Women's Hospital reported that delayed enhancement of the inward borders of the myocardium and left ventricular ejection fraction are powerful, complementary predictors of sudden death. (diagnosticimaging.com)
  • The age-adjusted incidence of out-of hospital cardiac arrest per 10,000 adults is 10.1 among blacks, 6.5 among Hispanics, and 5.8 among Caucasians. (lewrockwell.com)
  • This is equivalent to 3338 cardiac deaths in adults aged 16-64 years. (forensicmed.co.uk)
  • Even after adjusting for cardiovascular, behavioral and socioeconomic factors, black adults remain twice as likely to die from sudden cardiac death (SCD) as whites, suggests a study published in the Journal of the American College of Cardiology . (cardiovascularbusiness.com)
  • The death certificate and the autopsy listed "hypertensive cardiovascular disease with marked cardiomegaly" as the cause of death with "mitral valve prolapse, clinical history of hypertension, and left bundle branch block" as significant other conditions. (cdc.gov)
  • The autopsy, completed fi re fi ghting, the personal protective equipment used by the Medical Examiner, listed "hypertensive/isch- by fi re fi ghters, and the various components of the emic cardiovascular disease (CVD)" as the cause of National Fire Protection Association (NFPA) 1582, death. (cdc.gov)
  • We sought to evaluate the association between markers of mineral metabolism and sudden cardiac death (SCD) among the 2312 participants from the Cardiovascular Health Study who were free of clinical cardiovascular disease at baseline. (ahajournals.org)
  • A clinical trial the group presented at the SCMR meeting indicates that evidence of myocardial midwall fibrosis observed with delayed-enhancement CMR is better than ejection fraction or ventricular volume measures for predicting future death and hospitalization from cardiovascular disease. (diagnosticimaging.com)
  • 2 Statistics for deaths of police on duty that are attributable to cardiovascular disease events are not well documented but are estimated to account for 7% of fatalities. (bmj.com)
  • Talk to your doctor if you are concerned about your risks of sudden cardiac arrest. (seton.net)
  • Main outcome measures Observed and expected sudden cardiac death counts and relative risks for sudden cardiac death events during specific strenuous duties versus routine/non-emergency activities. (bmj.com)
  • But are the cardiac risks in these events sufficient to warrant planned action, or should the spectre of sudden cardiac death be regarded as a rare and unwelcome intruder whose occasional presence cannot be prevented? (bmj.com)
  • Clinical cardiologists are encountering an important challenge in the care of families with inherited cardiac diseases. (springer.com)
  • The risk of sudden death from LQTS can be significantly reduced with the correct medication and clinical treatment," says paediatric cardiologist Associate Professor Jon Skinner of Starship Children's Hospital. (medindia.net)
  • We recently evaluated SD in New York (NY) and Maryland (MD) racehorses in a study comparing clinical information, postmortem evaluation including cardiac dissection, and cardiac conduction system histopathology. (cornell.edu)
  • For many in the black community, their first clinical presentation of any cardiovascular issue is a sudden cardiac death event. (cardiovascularbusiness.com)
  • Understanding these cardiac adaptive mechanisms in hibernators may suggest new strategies to protect non-hibernating animals, especially humans, from fatal cardiac arrhythmias induced by hypothermic stresses and myocardial ischemia. (medicalxpress.com)
  • Ventricular irritability can be mediated by alcohol and drugs, including caffeine and cocaine, whilst myocardial depression leading to delayed conduction and cardiac standstill can be mediated by parasympathetic activity or electrolyte disturbances. (forensicmed.co.uk)
  • The risk of sudden death after myocardial infarction is described particularly with regard to the era of early reperfusion/stent insertion. (bjcardio.co.uk)