Death. Medical search

The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.

Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.

Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.

Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)

A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)

Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.

Conceptual response of the person to the various aspects of death, which are based on individual psychosocial and cultural experience.

A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a death domain due to the fact that many of these receptors are involved in signaling APOPTOSIS. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

Elements of limited time intervals, contributing to particular results or situations.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

All deaths reported in a given population.

Postmortem examination of the body.

A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.

The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)

An infant during the first month after birth.

Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

A cell line derived from cultured tumor cells.

Endogenous and exogenous compounds and that either inhibit CASPASES or prevent their activation.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.

An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.

A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.

Postnatal deaths from BIRTH to 365 days after birth in a given population. Postneonatal mortality represents deaths between 28 days and 365 days after birth (as defined by National Center for Health Statistics). Neonatal mortality represents deaths from birth to 27 days after birth.

Intracellular signaling adaptor proteins that bind to the cytoplasmic death domain region found on DEATH DOMAIN RECEPTORS. Many of the proteins in this class take part in intracellular signaling from TUMOR NECROSIS FACTOR RECEPTORS.

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

A member of the Bcl-2 protein family that reversibly binds MEMBRANES. It is a pro-apoptotic protein that is activated by caspase cleavage.

The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)

Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.

A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.

A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.

Established cell cultures that have the potential to propagate indefinitely.

Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.

The killing of one person by another.

NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).

The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.

The act of killing oneself.

Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.

The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Maternal deaths resulting from complications of pregnancy and childbirth in a given population.

Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)

Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.

A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.

A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad protein inhibits the activity of BCL-XL PROTEIN.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

An inhibitory T-lymphocyte receptor that has specificity for CD274 ANTIGEN and PROGRAMMED CELL DEATH 1 LIGAND 2 PROTEIN. Signaling by the receptor limits T cell proliferation and INTERFERON GAMMA synthesis. The receptor also may play an essential role in the regulatory pathway that induces PERIPHERAL TOLERANCE.

Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved death domains that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.

Used for general articles concerning statistics of births, deaths, marriages, etc.

The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.

Accidental or deliberate use of a medication or street drug in excess of normal dosage.

Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.

The confinement of a patient in a hospital.

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.

Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.

A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

A CELL LINE derived from human T-CELL LEUKEMIA and used to determine the mechanism of differential susceptibility to anti-cancer drugs and radiation.

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.

A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.

Medical and nursing care of patients in the terminal stage of an illness.

Refers to the whole process of grieving and mourning and is associated with a deep sense of loss and sadness.

A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.

Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.

A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

Deaths that occur before LIFE EXPECTANCY is reached within a given population.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

Transport proteins that carry specific substances in the blood or across cell membranes.

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.

Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.

The process by which chemical compounds provide protection to cells against harmful agents.

Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.

Glycoproteins found on the membrane or surface of cells.

A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.

A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.

An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.

A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

Disruption of structural continuity of the body as a result of the discharge of firearms.

A 34 kDa signal transducing adaptor protein that associates with TUMOR NECROSIS FACTOR RECEPTOR TYPE 1. It facilitates the recruitment of signaling proteins such as TNF RECEPTOR-ASSOCIATED FACTOR 2 and FAS ASSOCIATED DEATH DOMAIN PROTEIN to the receptor complex.

A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.

The return of a sign, symptom, or disease after a remission.

The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.

A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.

Pathological conditions involving the HEART including its structural and functional abnormalities.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

The application of pathology to questions of law.

Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.

The event that a FETUS is born dead or stillborn.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Tumors or cancer of the LUNG.

Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

Refers to animals in the period of time just after birth.

A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 3 and CASPASE 10. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.

The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.

Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.

ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.

A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).

The number of CELLS of a specific kind, usually measured per unit volume or area of sample.

Research techniques that focus on study designs and data gathering methods in human and animal populations.

The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

A CARD signaling adaptor protein that plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY). It binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX and activates INITIATOR CASPASES such as CASPASE 9.

Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.

Tumors or cancer of the human BREAST.

An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)

A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)

Inhaling and exhaling the smoke of burning TOBACCO.

The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.

Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.

Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.

Disease having a short and relatively severe course.

A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.

Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.

A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

Proteins prepared by recombinant DNA technology.

The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.

Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.

A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.

Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.

Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.

Number of deaths of children between one year of age to 12 years of age in a given population.

A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.

Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.

Normal, appropriate sorrowful response to an immediate cause. It is self-limiting and gradually subsides within a reasonable time.

Deaths occurring from the 28th week of GESTATION to the 28th day after birth in a given population.

A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.

Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

The expiry date of man: a synthesis of evolutionary biology and public health. (1/646)

In industrialised countries, mortality and morbidity are dominated by age related chronic degenerative diseases. The health and health care needs of future populations will be heavily determined by these conditions of old age. Two opposite scenarios of future morbidity exist: morbidity might decrease ("compress"), because life span is limited, and the incidence of disease is postponed. Or morbidity might increase ("expand"), because death is delayed more than disease incidence. Optimality theory in evolutionary biology explains senescence as a by product of an optimised life history. The theory clarifies how senescence is timed by the competing needs for reproduction and survival, and why this leads to a generalised deterioration of many functions at many levels. As death and disease are not independent, future morbidity will depend on duration and severity of the process of senescence, partly determined by health care, palliating the disease severity but increasing the disease duration by postponing death. Even if morbidity might be compressed, health care needs will surely expand. (+info)

The case for a statutory 'definition of death'. (2/646)

Karen Quinlan, the American girl who has lain in deep coma for many months, is still 'alive', that is to say, her heart is still beating and brain death has not occurred. However, several other cases have raised difficult issues about the time of death. Dr Skegg argues that there is a case for a legal definition of death enshrined in statutory form. He suggests that many of the objections to a statutory provision on death are misplaced, and that a statute concerning the occurrence of death could remove all doubts in the minds of both doctors and public as to whether a 'beating heart cadaver' was dead or alive for legal purposes. (+info)

beta2-adrenergic receptor-selective agonist clenbuterol prevents Fas-induced liver apoptosis and death in mice. (3/646)

Stimulation of the cAMP-signaling pathway modulates apoptosis in several cell types and inhibits Jo2-mediated apoptosis in cultured rat hepatocytes. No information is yet available as to whether the hepatic beta2-adrenergic receptor (AR) expression level, including beta2-AR-dependent adenylyl cyclase activation, modulates hepatocyte sensitivity to apoptosis in vivo or whether this sensitivity can be modified by beta2-AR ligands. We have examined this using C57BL/6 mice, in which hepatic beta2-AR densities are low, and transgenic F28 mice, which overexpress beta2-ARs and have elevated basal liver adenylyl cyclase activity. The F28 mice were resistant to Jo2-induced liver apoptosis and death. The beta-AR antagonist propranolol sensitized the F28 livers to Jo2. In normal mice clenbuterol, a beta2-AR-specific agonist, considerably reduced Jo2-induced liver apoptosis and death; salbutamol, another beta2-AR-selective agonist, also reduced Jo2-induced apoptosis and retarded death but with less efficacy than clenbuterol; and propranolol blocked the protective effect of clenbuterol. This indicates that the expression level of functional beta2-ARs modulates Fas-regulated liver apoptosis and that this apoptosis can be inhibited in vivo by giving beta2-AR agonists. This may well form the basis for a new therapeutic approach to diseases involving abnormal apoptosis. (+info)

Antitumor and immunotherapeutic effects of activated invasive T lymphoma cells that display short-term interleukin 1alpha expression. (4/646)

Expression of cytokines in malignant cells represents a novel approach for therapeutic treatment of tumors. Previously, we demonstrated the immunostimulatory effectiveness of interleukin 1alpha (IL-1alpha) gene transfer in experimental fibrosarcoma tumors. Here, we report the antitumor and immunotherapeutic effects of short-term expression of IL-1alpha by malignant T lymphoma cells. Activation in culture of T lymphoma cells with lipopolysaccharide-stimulated macrophages induces the expression of IL-1alpha. The short-term expression of IL-1alpha persists in the malignant T cells for a few days (approximately 3-6 days) after termination of the in vitro activation procedure and, thus, has the potential to stimulate antitumor immune responses in vivo. As an experimental tumor model, we used the RO1 invasive T lymphoma cell line. Upon i.v. inoculation, these cells invade the vertebral column and compress the spinal cord, resulting in hind leg paralysis and death of the mice. Activated RO1 cells, induced to express IL-1alpha in a short-term manner, manifested reduced tumorigenicity: approximately 75% of the mice injected with activated RO1 cells remained tumor free. IL-1 was shown to be essential for the eradication of activated T lymphoma cells because injection of activated RO1 cells together with IL-1-specific inhibitors, i.e., the IL-1 receptor antagonist or the M 20 IL-1 inhibitor, reversed reduced tumorigenicity patterns and led to progressive tumor growth and death of the mice. Furthermore, activated RO1 cells could serve as a treatment by intervening in the growth of violent RO1 cells after tumor take. Thus, when activated RO1 cells were injected 6 or 9 days after the inoculation of violent cells, mortality was significantly reduced. IL-1alpha, in its unique membrane-associated form, in addition to its cytosolic and secreted forms, may represent a focused adjuvant for potentiating antitumor immune responses at low levels of expression, below those that are toxic to the host. Further assessment of the immunotherapeutic potential of short-term expression of IL-1alpha in activated tumor cells may allow its improved application in the treatment of malignancies. (+info)

Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. (5/646)

In most cells, the ubiquitously expressed Na+/H+ exchanger isoform 1 (NHE1) is thought to be a primary regulator of pH homeostasis, cell volume regulation, and the proliferative response to growth factor stimulation. To study the function of NHE1 during embryogenesis when these cellular processes are very active, we targeted the Nhe1 gene by replacing the sequence encoding transmembrane domains 6 and 7 with the neomycin resistance gene. NHE activity assays on isolated acinar cells indicated that the targeted allele is functionally null. Although the absence of NHE1 is compatible with embryogenesis, Nhe1 homozygous mutants (-/-) exhibit a decreased rate of postnatal growth that is first evident at 2 wk of age. At this time, Nhe1 -/- animals also begin to exhibit ataxia and epileptic-like seizures. Approximately 67% of the -/- mutants die before weaning. Postmortem examinations frequently revealed an accumulation of a waxy particulate material inside the ears, around the eyes and chin, and on the ventral surface of the paws. Histological analysis of adult tissues revealed a thickening of the lamina propria and a slightly atrophic glandular mucosa in the stomach. (+info)

Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice. (6/646)

Secreted forms of the beta-amyloid precursor protein (beta-APP) have neuroprotective properties in vitro and may be involved in the containment of neuronal excitation. To test whether loss of secreted forms of beta-APP (sAPPs) may enhance excitotoxic responses, we injected mice homozygous for a targeted mutation of the beta-APP gene (beta-APPDelta/Delta) intraperitoneally with kainic acid. We found that in these mice, kainic acid induced seizures initiated earlier, and acute mortality was enhanced compared to isogenic wild-type mice independently from the callosal agenesis phenotype observed to occur at increased frequency in APP mutant mice. Expression of c-fos in cortex and cingulate gyrus was enhanced in beta-APPDelta/Delta mice, although the amount of structural damage and apoptosis in the hippocampal pyramidal cell layer and cortex was similar to that of controls. When cerebellar granule cell cultures and cortical neuronal cultures were challenged with glutamate receptor agonists, the rates of cell death and apoptosis of beta-APPDelta/Delta mice were indistinguishable from those of controls. Therefore, deficiency of sAPPs causes facilitation of seizure activity in the absence of enhanced cell death. Since enhanced seizures were observed also in mice homozygous for a deletion of the entire beta-APP gene, this phenotype results from a loss of APP rather than from a dominant effect of APPDelta. (+info)

Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice. (7/646)

Hepatocyte nuclear factors 3 (HNF-3) belong to an evolutionarily conserved family of transcription factors that are critical for diverse biological processes such as development, differentiation, and metabolism. To study the physiological role of HNF-3alpha, we generated mice that lack HNF-3alpha by homologous recombination in embryonic stem cells. Mice homozygous for a null mutation in the HNF-3alpha gene develop a complex phenotype that is characterized by abnormal feeding behavior, progressive starvation, persistent hypoglycemia, hypotriglyceridemia, wasting, and neonatal mortality between days 2 and 14. Hypoglycemia in HNF-3alpha-null mice leads to physiological counter-regulatory responses in glucocorticoid and growth hormone production and an inhibition of insulin secretion but fails to stimulate glucagon secretion. Glucagon-producing pancreatic alpha cells develop normally in HNF-3alpha-/- mice, but proglucagon mRNA levels are reduced 50%. Furthermore, the transcriptional levels of neuropeptide Y are also significantly reduced shortly after birth, implying a direct role of HNF-3alpha in the expression of these genes. In contrast, mRNA levels were increased in HNF-3 target genes phosphofructo-2-kinase/fructose-2,6-bisphophatase, insulin growth factor binding protein-1, and hexokinase I of HNF-3alpha-null mice. Mice lacking one or both HNF-3alpha alleles also show impaired insulin secretion and glucose intolerance after an intraperitoneal glucose challenge, indicating that pancreatic beta-cell function is also compromised. Our results indicate that HNF-3alpha plays a critical role in the regulation of glucose homeostasis and in pancreatic islet function. (+info)

Does hospital at home for palliative care facilitate death at home? Randomised controlled trial. (8/646)

OBJECTIVE: To evaluate the impact on place of death of a hospital at home service for palliative care. DESIGN: Pragmatic randomised controlled trial. SETTING: Former Cambridge health district. PARTICIPANTS: 229 patients referred to the hospital at home service; 43 randomised to control group (standard care), 186 randomised to hospital at home. INTERVENTION: Hospital at home versus standard care. MAIN OUTCOME MEASURES: Place of death. RESULTS: Twenty five (58%) control patients died at home compared with 124 (67%) patients allocated to hospital at home. This difference was not significant; intention to treat analysis did not show that hospital at home increased the number of deaths at home. Seventy three patients randomised to hospital at home were not admitted to the service. Patients admitted to hospital at home were significantly more likely to die at home (88/113; 78%) than control patients. It is not possible to determine whether this was due to hospital at home itself or other characteristics of the patients admitted to the service. The study attained less statistical power than initially planned. CONCLUSION: In a locality with good provision of standard community care we could not show that hospital at home allowed more patients to die at home, although neither does the study refute this. Problems relating to recruitment, attrition, and the vulnerability of the patient group make randomised controlled trials in palliative care difficult. While these difficulties have to be recognised they are not insurmountable with the appropriate resourcing and setting. (+info)

... of deaths by year List of expressions related to death Memento mori Near-death experience Origin-of-death myth Spiritual death ... This process allows the individuals soul to withstand death and transform into life after death. In Hindu texts, death is ... of the Dead Deathbed Death drive Death row Death trajectory Dying Dying declaration End-of-life care Eschatology Faked death ... Death is the center of many traditions and organizations; customs relating to death are a feature of every culture around the ...

https://en.wikipedia.org/wiki/Death

Heaton, Dave (29 March 2015). "Eternal Death: Eternal Death". PopMatters. "Review: The Crown - Eternal Death". The Metal Crypt ... Eternal Death at AllMusic. Retrieved 26 March 2021. Snow, Drew (14 July 1997). "Crown of Thorns - _Eternal Death_". Chronicles ... "Eternal Death". Encyclopaedia Metallum. Retrieved 26 March 2021. "Album Review: Crown Of Thorns - Eternal Death". DemonBit. 20 ... Eternal Death is the second album of Crown of Thorns. It was originally released in 1997 and later re-issued under the band's ...

https://en.wikipedia.org/wiki/Eternal_Death

Death in Sanatorium B.J. Winslow - Death in Morgue Joan Farrell - Traci "Death Tunnel - Trailer - Showtimes - Cast - Movies - ... Barton, Steve (2006-02-24). "Death Tunnel (2005)". Dread Central. Retrieved 2022-11-03. Death Tunnel at IMDb Death Tunnel at ... Death Tunnel is a 2005 horror movie filmed at the Waverly Hills Sanatorium. It stars Steffany Huckaby, Annie Burgstede, Kristin ... "Film Review: Death Tunnel (2005)". Horror News , HNN. 2019-08-25. Retrieved 2022-11-03. ...

https://en.wikipedia.org/wiki/Death_Tunnel

... is anxiety caused by thoughts of one's own death, and is also referred to as thanatophobia (fear of death). Death ... Usually as it relates to their personal death. Death anxiety can mean: fear of death, fear of dying, fear of being alone, fear ... Ray, J. J.; Najman, J. (1975-01-01). "Death Anxiety and Death Acceptance: A Preliminary Approach". OMEGA - Journal of Death and ... Cicirelli, Victor G. (November 1998). "Personal meanings of death in relation to fear of death". Death Studies. 22 (8): 713-733 ...

https://en.wikipedia.org/wiki/Death_anxiety

... is the inability of an organism to function in an ecological context, leading to death. This term can be used ... it can also lead to ecological death. An effect caused by DDT is shell thinning in bird eggs, leading to the death of the chick ... If this alteration does not directly cause death, but impacts the behavior or physiology of the organism, it can also lead to ... This is an example of a physiological sublethal effect leading to ecological death. Scott, G.R., and K.A. Sloman. 2004. The ...

https://en.wikipedia.org/wiki/Ecological_death

"Reviews: Septic Death - Crossed Out Twice CD". Ox-Fanzine. Retrieved 2021-10-24. "Integrity Pay Tribute to Septic Death on " ... Septic Death was an American hardcore punk band active in the 1980s. The foursome from Boise, Idaho was a major influence for ... Septic Death was among the first hardcore bands in the United States. Their music was fast but also very technical. The lyrics ... "Septic Death - Now That I Have The Attention, What Do I Do With It?". Pusfan.com. Retrieved 2021-10-24. "Burial Mai So". ...

https://en.wikipedia.org/wiki/Septic_Death

... (later also intended as a contraction of In Death of Steve Sylvester) is an Italian heavy metal band. Death SS was ... Yiva Asker: Death SS. In: Jon Kristiansen: Metalion: The Slayer Mag Diaries. Brooklyn, NY: Bazillion Points Books 2011, p. ... Jean: Death SS. "Album - Classifica settimanale WK 37 (dal 2018-09-07 al 2018-09-13)" (in Italian). Federazione Industria ... in Death of Steve Sylvester. There would be many line-up changes in the years to come, with Sylvester once again being the only ...

https://en.wikipedia.org/wiki/Death_SS

The smell of death is a smell occurring during decomposition. It is made up of over 800 different chemicals. There have been ... The "smell of death" research has been permitted as evidence in court. In the 2011 Caylee Anthony case, in which Casey Anthony ... "Scientists search for death's aroma , April 4, 2016 Issue - Vol. 94 Issue 14 , Chemical & Engineering News". cen.acs.org. ... "The smell of death". Scienceline. 2016-02-22. Retrieved 2020-02-07. Pennisi, E. (2015). "Researchers isolate the 'human smell ...

https://en.wikipedia.org/wiki/Death_smell

... is a 1929 mystery detective novel by the British writer Gladys Mitchell. It introduced the character of Mrs ... The title is sometimes written as A Speedy Death. It was loosely adapted for an episode of the 1998 television series The Mrs ... Modern Literature and the Death Penalty, 1890-1950. Springer Nature, 2020. Reilly, John M. Twentieth Century Crime & Mystery ...

https://en.wikipedia.org/wiki/Speedy_Death

In most jurisdictions, death threats are a serious type of criminal offence. Death threats are often covered by coercion ... A death threat is a threat, often made anonymously, by one person or a group of people to kill another person or group of ... Sometimes, death threats are part of a wider campaign of abuse targeting a person or a group of people (see terrorism, mass ... For example, a death threat could be used to dissuade a public figure from pursuing a criminal investigation or an advocacy ...

https://en.wikipedia.org/wiki/Death_threat

Simmu, only a few days old, sees Death come for Narasen and forms a permanent hatred for death. Simmu is raised by the minor ... He starts Simmu on a quest to gain immortality to oppose Lord Death. Narasen, in Death's kingdom, defies Uhlume and begins a ... Narasen takes on most of Uhlume's work of giving death to the dying. Death's Master won the British Fantasy Society's August ... Death's Master is a fantasy novel by British writer Tanith Lee, the second book in her series Tales from the Flat Earth. It won ...

https://en.wikipedia.org/wiki/Death's_Master

A death clock may refer to: An estimate of life expectancy, often tongue-in-cheek Trump Death Clock This disambiguation page ... lists articles associated with the title Death clock. If an internal link led you here, you may wish to change the link to ...

https://en.wikipedia.org/wiki/Death_clock

In it, he concludes that "Death Gospel offers an interesting rejoinder to a culture that denies death and decay, insisting ... Death Gospel is a genre of music popularized in the 21st century by Soul/Americana artist Adam Arcuragi, and his band. It draws ... In Arcuragi's own words (as published by the Huffington Post), the Death component and tie to the music is "anything that sees ... The theme of Death, serves as the common denominator of all human beings - the inevitable shared fate that makes life so ...

https://en.wikipedia.org/wiki/Death_Gospel

The death wail is mentioned in many literary works: "She began the high, whining keen of the death wail... It rose to a high ... The death wail is a keening, mourning lament, generally performed in ritual fashion soon after the death of a member of a ... Armitage, Edward; WRF Love (1923). The death wail of the Ginginbarra people of Wide Bay. Describes the death wail in the ... British Library website with downloadable sound file of 1898 death wail. Requires Windows Media Player. Video of Death wail ...

https://en.wikipedia.org/wiki/Death_wail

... , p. 21 (last page with text) Death's Domain, In Discworld Wiki Death's Domain (Discworld Mapp), In Discworld ... Death's house. Paul., Kidry (1999). Death's domain : a Discworld mapp. Corgi. ISBN 9780552146722. OCLC 43459784. Death's Domain ... Death's Domain is a book by Terry Pratchett and Stephen Briggs, and illustrated by Paul Kidby. It is the fourth in the ... In Death's Domain, the concept of steam locomotives on Discworld is introduced, which became the main theme of Pratchett's ...

https://en.wikipedia.org/wiki/Death's_Domain

"Death Benefit" is the 20th episode of the third season of the American television drama series Person of Interest. It is the ... "Death Benefit" received near critical acclaim from critics. Matt Fowler of IGN gave the episode an "amazing" 9 out of 10 rating ... Finch is conflicted, as the Machine would only order a death when a great amount of people's lives are endangered. Finch fails ... The title refers to "Death benefit", a payment given to anyone with a life insurance policy when the insured person dies. ...

https://en.wikipedia.org/wiki/Death_Benefit

ISBN 978-0-81084-244-1. Death Hunt at IMDb Death Hunt at Rotten Tomatoes Death Hunt at the TCM Movie Database Death Hunt at ... Death Hunt was first released on VHS by CBS/Fox video in the early 1980s. A DVD of Death Hunt was released by Anchor Bay ... "Death Hunt (1981); 'Death Hunt' pits Bronson against Marvin." The New York Times, May 22, 1981. Maltin 2009, p. 331. Anderson, ... "Death Hunt (1981)." Aerofiles. Retrieved: November 29, 2014. "Butch And Sundance: The Early Days/Death Hunt." Archived 2014-12- ...

https://en.wikipedia.org/wiki/Death_Hunt

... , colloquially known as playing dead, feigning death, or playing possum, is a behavior in which animals take on ... Apparent death is separate from the freezing behavior seen in some animals. Apparent death is a form of animal deception ... Death-feigning birds often take advantage of escape opportunities; tonic immobility in quail reduces the probability of the ... Apparent death is also referred to as thanatosis, animal hypnosis, immobilization catatonia, or tonic immobility, the latter of ...

https://en.wikipedia.org/wiki/Apparent_death

There were death squads used by both the Falangists and Republicans during this conflict. Prominent victims of the era's death ... In Latin America, death squads first appeared in Brazil where a group called Esquadrão da Morte (literally "Death Squad") ... Death Squad activity stretched well into the Reagan years (1981-1989) as well.[citation needed] Honduras also had death squads ... One of the soldiers on the death squad named Aureliano Blanquet would then later be sentenced to death by firing squad under ...

https://en.wikipedia.org/wiki/Death_squad

... is a docu-series directed by Ricki Stern about near-death experiences and beliefs in life after death, and ... "Surviving Death - Listings". The Futon Critic. Retrieved 16 January 2021. Surviving Death on Netflix Surviving Death at IMDb ( ... A review in the Explica magazine described Surviving Death as "one of the biggest nonsense of this incipient movie season", "a ... It accuses Surviving Death of "taking advantage of desperate people", as Stern's supporting narratives reiterates the ...

https://en.wikipedia.org/wiki/Surviving_Death

... is an album by Swedish band Impious. It was released on November 23, 2009, in Europe and on November 24, 2009 ... 09 As Death Lives in Me 04:18 Irreligious State of War 03:12 v t e (Articles lacking sources from November 2018, All articles ...

https://en.wikipedia.org/wiki/Death_Domination

... is a documentary film by anthropologist Napoleon Chagnon, that explores the role of the shaman within the ... engaging in symbolic death and cannibalism. The film was awarded the American Film Festival Blue Ribbon. "Macho anthropology - ... Documentary films about death, American documentary films, 1970s English-language films, 1970s American films, All stub ...

https://en.wikipedia.org/wiki/Magical_Death

... is the number of dead as a result of a war, disaster, or other event. It may also refer to: Death Toll, 2008 action ... as Death Toll List of lists organized by death toll This disambiguation page lists articles associated with the title Death ... Look up death toll in Wiktionary, the free dictionary. ...

https://en.wikipedia.org/wiki/Death_toll

The first signs of the death/doom genre originated in the mid-1980s when early progenitors like Dream Death began to mix ... In turn, death-doom gave rise to the closely related genre of funeral doom as well as to the more melodic, gloomy and romantic ... The tag of death/doom seemed to become less popular towards the end of the decade as many of the scene progenitors abandoned ... Death-doom is an extreme subgenre of heavy metal. It combines the slow tempos and pessimistic or depressive mood of doom metal ...

https://en.wikipedia.org/wiki/Death-doom

... may refer to: Yungas Road, a notoriously treacherous route in Bolivia Kabul-Behsud Highway, a highway in Afghanistan ... noted for its frequency of Taliban-related killings This disambiguation page lists articles associated with the title Death ...

https://en.wikipedia.org/wiki/Death_Road

"Death Magnetic (Death in a Coffin) Rozm. XL". empik.com (in Polish). Archived from the original on September 12, 2008. ... Experience 2 A physical copy of the Death Magnetic CD. Experience 4 A box set of Death Magnetic on five 180-gram vinyl LP ... "Dutchcharts.nl - Metallica - Death Magnetic" (in Dutch). Hung Medien. Retrieved June 16, 2021. "Metallica: Death Magnetic" (in ... "Death Magnetic (Digital Download)". www.metallica.com. Retrieved January 26, 2019. "Grammy Award winners - Death Magnetic". ...

https://en.wikipedia.org/wiki/Death_Magnetic

"Ein Mann wird zum Killer - Death Force - Grindhouse Collection Vol. 2 Blu-ray". Blu-ray.com. Retrieved December 15, 2019. Death ... Death Force (also known as Vengeance Is Mine) is a 1978 martial arts exploitation film directed by Cirio H. Santiago and ... In June 2014, Death Force was released on DVD and Blu-ray in Germany by Subkultur Entertainment. Hunter, Rob (March 21, 2018 ... Smith, Richard Harland (May 11, 2016). "This Week on TCM Underground: Death Force (1978) and Clay Pigeon (1971)". Streamline. ...

https://en.wikipedia.org/wiki/Death_Force

"Death Dispatch". The Avengers Forever!. Retrieved 28 April 2012. "Death Dispatch" at IMDb Episode overview on The Avengers ... "Death Dispatch" is the thirteenth episode of the second series of the 1960s cult British spy-fi television series The Avengers ... "Death Dispatch". The Avengers. Retrieved 10 June 2022. Rogers, Dave (25 April 1983). The Avengers. ITV Books in association ...

https://en.wikipedia.org/wiki/Death_Dispatch

... may refer to: Death Trip (1967 film), part of the Kommissar X series "Death Trip", a 1986 episode of American TV ... "Death Trip", a song on 1973 album The Human Menagerie by Cockney Rebel Death Trip, a 1992 album by band Tar Babies Death Trip, ... a Chinese film directed by Billy Tang Death Trip, a 2015 Malaysian film Death Trip, a 2021 home video "Death Trip", a song on ... Äijälä All pages with titles containing Death Trip This disambiguation page lists articles associated with the title Death Trip ...

https://en.wikipedia.org/wiki/Death_Trip

... may refer to: Death notice, a type of obituary "Death Notice", an episode of the Starsky & Hutch television series ... Death Notice (novel), a 2014 work of detective fiction Death Notice (film), a 2022 Hong Kong action thriller based on the book ... This disambiguation page lists articles associated with the title Death Notice. If an internal link led you here, you may wish ...

https://en.wikipedia.org/wiki/Death_Notice

Deaths, percent of total deaths, and death rates for the 15 leading causes of death: United States and each State ... Trends in Leading causes of death from Health, United States. *Death Rates by Marital Status for Leading Causes of Death: ...

https://www.cdc.gov/nchs/fastats/leading-causes-of-death.htm

Medical error is not included on death certificates or in rankings of cause of death. Martin Makary and Michael Daniel assess ... code to the cause of death.1 As a result, causes of death not associated with an ICD code, such as human and system factors, ... Death from medical care itself. Medical error has been defined as an unintended act (either of omission or commission) or one ... Medical error-the third leading cause of death in the US BMJ 2016; 353 :i2139 doi:10.1136/bmj.i2139 ...

https://www.bmj.com/content/353/bmj.i2139

Medical errors cause thousands of deaths each year. Changes to medical systems and the law can prevent many errors and save ... Death by medical error or accident is the nations leading cause of accidental death, exceeding all other causes of accidental ... Thats more than enough to make medical care gone awry the number three cause of death in the U.S., after heart disease and ... A meta-analysis of such studies concluded that the average annual death rate from such errors in the first decade of the 2000s ...

https://www.statnews.com/2021/08/04/medical-errors-accidents-ongoing-preventable-health-threat/

Cases and deaths data are assigned to dates based on when figures are publicly reported. For case and death seven-day averages ... For the U.S. national case and death count averages, the average is the sum of the average number of cases and deaths in all ... Arkansas added many deaths. The state indicated that many of the 289 deaths announced were from previous months.. ... Arkansas added many deaths. The state indicated that many of the 289 deaths announced were from previous months.. ...

https://www.nytimes.com/interactive/2021/us/covid-cases.html

Near-death experiences have gotten a lot of attention lately. The 2014 movie Heaven Is for Real, about a young boy who told his ... In I Knew Their Hearts, one of his books, he writes, "What do you say to a man who feels responsible for the death of half his ... Of those books, probably the single best overview is The Handbook of Near-Death Experiences: Thirty Years of Investigation, an ... For now, the death spike remains just one more disjointed piece of the NDE puzzle, which we have not yet figured out how to ...

https://www.theatlantic.com/magazine/archive/2015/04/the-science-of-near-death-experiences/386231/

Nationally, African-American deaths from COVID-19 are nearly two times greater than would be expected based on their share of ... White deaths from COVID-19 are lower than their share of the population in 37 states and the District of Columbia. ... Major holes in the data remain: 48% of cases and 9% of deaths still have no race tied to them. And that can hamper response to ... A heavy toll of African-American deaths. NPRs analysis finds that in 32 states plus Washington D.C., African Americans are ...

https://www.npr.org/sections/health-shots/2020/05/30/865413079/what-do-coronavirus-racial-disparities-look-like-state-by-state

The death penalty is a contentious topic among many legal minds in ... The death penalty is less about the victim of an incident and is a lot more about the social ramifications of the crime. The ... The death penalty is a contentious topic among many legal minds in India. There are some who are outrightly in favour of ... This can clearly be seen from the fact that, even after the convicts were sentenced to death and the rape laws were toughened, ...

https://theleaflet.in/death-penalty-is-premeditated-murder-in-the-name-of-societys-collective-conscience/

Cases, Deaths, & Testing Case & Death Demographic Trends Vaccination Distribution & Coverage Vaccine Effectiveness & ...

https://covid.cdc.gov/covid-data-tracker/

The League of Women Voters, a nonpartisan political organization, encourages informed and active participation in government, works to increase understanding of major public policy issues, and influences public policy through education and advocacy.. All content on this site is property of the League of Women Voters Education Fund ...

https://sites.google.com/a/leagueofwomenvoters.org/clearinghouse/social-policy/death-penalty

Browse the archive of articles on Cell Death & Disease ... immunogenic effects after immunogenic cancer cell death *A D ...

https://www.nature.com/cddis/articles?type=correspondence&error=cookies_not_supported&code=5d744624-8063-4d53-b6c8-1f35de749c8b

... You may qualify for a life-or-death emergency appointment if you need to travel internationally in 3 ... Call us to see if you qualify for life-or-death emergency service. If you qualify, we will try to make an appointment for you. ... Examples include a death certificate, statement from the mortuary, or letter from the hospital. The translation does not need ... The number you should call to make an appointment for Life-or-Death Emergency Service depends on the day of the week, and time ...

https://travel.state.gov/content/travel/en/passports/get-fast/emergencies.html

For weeks, there had been warnings that this was a potential death trap. Limas municipal government even declared the area an ... This article appeared in the The Americas section of the print edition under the headline "Death foretold" ...

https://www.economist.com/the-americas/2002/01/03/death-foretold

Death Wish: Directed by Eli Roth. With Bruce Willis, Vincent DOnofrio, Elisabeth Shue, Camila Morrone. Dr. Paul Kersey is an ...

https://www.imdb.com/title/tt1137450/

... have a profound impact on those who experience them. ... The scene above exemplifies what many people who have had a near-death experience (NDE) describe. NDEs can be caused by any ... Near-death Experiences and Their Impact on Individuals - Medscape - Oct 31, 2022. ...

https://www.medscape.com/viewarticle/983138

A horror film destined to be a cult classic due to its intensity and twists of raw survival. , Check out Death Hunt on Indiegogo.

https://www.indiegogo.com/projects/death-hunt

See an archive of all death panels stories published on Intelligencer. ... White House Claims Death Panels Dont Exist!Their new website is devoted to debunking health-care-reform rumors. ... Sarah Palins Prediction of Bleak Health-Care Dystopia Widely MockedBut what if her claims of Obamas "death panels" are true? ... Sarah Palin Defeats Death Panels She InventedThis has got to be a victory for someone. ...

https://nymag.com/intelligencer/tags/death-panels/

Lisa Marie Presley Pays Tribute to Her Late Son Benjamin Keough on the Anniversary of His Death. Keough died in his home from a ... Wynonna Judd Addresses Her Mother Naomi Judds Death for the First Time. The country singer said in a new interview that she " ... Olivia Newton-Johns Daughter Reflects on Her Mothers Death. The singer passed away earlier this month after a 30-year battle ... Cristiano Ronaldo and Georgina Rodríguez Mourning Death of Newborn Son. The soccer star added that the birth of his twin sister ...

https://www.vanityfair.com/topic/death

The process of programmed cell death can either induce anti-inflammatory immune responses or actively promote inflammation. ... The process of programmed cell death can either induce anti-inflammatory immune responses or actively promote inflammation. ... Stockinger, B. Cause of death matters. Nature 458, 44-45 (2009). https://doi.org/10.1038/458044a ...

https://www.nature.com/articles/458044a?error=cookies_not_supported&code=bd975df1-f26a-4322-b5a5-425c41032ebc

Death Match: A Michele Shepard Story (The True Death Series) Book 7 of 7: The True Death Series , by R.K. Gleason , Sep 5, 2017 ... The Death Match (Dead Man Book 13) Book 13 of 22: Dead Man , by Christa Faust , Lee Goldberg , et al. , Sep 18, 2012 ... Death Match (A Magic Bullet Novel Book 2) Book 2 of 4: A Magic Bullet Novel , by Annabel Chase , Jul 29, 2016 ... Death Match (The Coastal Suspense Series Book 2) Book 2 of 6: Coastal Suspense , by Emma Rose Watts , Feb 2, 2018 ...

https://www.amazon.com/s/?node=283155&tag=wsirn2020-20&keywords=Death+Match

Get all the latest new about Death Dome from GameSpots industry-leading news coverage! ...

https://www.gamespot.com/games/death-dome/news/

... Pete Shellem, crime reporter. Radley Balko , From the February 2010 issue. ... Shellems death wasnt widely reported outside of Pennsylvania. In fact, his work, impressive as it was, rarely made a splash ... Carbone then pulled a knife from her purse and stabbed Lint to death. Prosecutors didnt believe her story. She was tried and ...

https://reason.com/2009/12/14/death-of-a-watchdog-pete-shell/

A lot of death, I thought, and when we met at a coffee bar on Saturday, I asked him how he got through a week where he was ... Before her death in 1996, Mitford had all but put the finishing touches on an updated account of the funeral industry, which ... In the first page of his lyrical account of deaths and burials, Lynch lets you know about money: "In a good year the gross is ... The American Way of Death Revisited,. by Jessica Mitford, Alfred A. Knopf,. 296 pp.; $25.. Article continues below. ...

https://www.christianitytoday.com/ct/1999/april26/9t5082.html?utm_medium=widgetsocial

... (24-Jul-1974). Director: Michael Winner. Writer: Wendell Mayes. From novel: Death Wish by Brian Garfield. Music ... After the death of his wife at the hands of muggers, a New York City architect thwarts his own mugging by killing the mugger ...

https://nndb.com/films/979/000032883/

According to an expert from an entry in the Register of Deaths, Her Majesty died on September 8, 2022 at 3:10 PM at Balmoral ... On Thursday, a document was published by the National Records of Scotland which lists that the late monarchs death was due to ... The cause of Queen Elizabeths death has been revealed. ... Queen Elizabeths Cause of Death Revealed. Read full article. ... According to an expert from an entry in the Register of Deaths, Her Majesty died on September 8, 2022 at 3:10 PM at Balmoral ...

https://www.yahoo.com/entertainment/queen-elizabeth-cause-death-revealed-071032497.html

This educational activity provides training on how cause-of-death information is used, how to complete death certificates, when ... Improving Cause of Death Reporting accreditation Information Table. Complete the activity. Complete the evaluation at www.cdc. ... Improving Cause of Death Reporting Information Table. FACULTY/. CREDENTIALS:. Lee Anne Flagg, PhD, Statistician (Health), ... To receive continuing education (CE) for WB4581-Improving Cause-of-Death Reporting please visit TCEO and follow these 9 Simple ...

https://www.cdc.gov/nchs/nvss/improving-cause-of-death-reporting.htm

... including the high-profile death of transgender woman Muhlaysia Booker. ... Booker was shot to death in May, weeks after a video of her being attacked by a mob spread across the internet. Her death drew ... Both victims were shot to death, one on May 22 and the other on May 23. A tip in the first case led police to Lyles, who was ... Geron said Lyles is also a person of interest in the death of Chynal Lindsey, whose body was found in a lake less than two ...

https://www.cnn.com/2019/06/12/us/muhlaysia-booker-suspect-arrested/index.html

... making Connecticut the 17th state to abolish the death penalty. ... Dannel Malloy signed the states death penalty repeal bill into ... It abolished the death penalty for future cases, but it does not affect sentences for the 11 inmates currently on death row in ... The 11 men currently on death row in Connecticut are far more likely to die of old age than they are to be put to death, he ... An isolated and vacant cell block at the Osborn prison in Somers is expected to be used for the death row inmates who are now ...

https://abcnews.go.com/US/connecticut-repeals-death-penalty-governor-dannel-malloy-signs/story?id=16212552

... which is the leading cause of death in children between 1 month and one year old ... Learn how to reduce the risk of Sudden Infant Death Syndrome (SIDS), ... Sudden infant death syndrome (SIDS) is the sudden, unexplained death of an infant younger than one year old. Some people call ... Sudden Unexpected Infant Death and Sudden Infant Death Syndrome: Parents and Caregivers (Centers for Disease Control and ...

https://medlineplus.gov/suddeninfantdeathsyndrome.html

Drug, alcohol deaths increasing among US adults 65 and older, CDC data shows Deaths related to drug misuse and alcohol abuse ... Death. Rancho Cordova man slashed with machete dies The suspect in the attack, 42-year-old James Hall, appeared in court Friday ... Mexico investigates death of U.S. woman seen being beaten in video A video apparently taped at a luxury villa in San Jose del ... A woman has been arrested in connection to the death of an infant that was born at a homeless camp in San Joaquin County. ...

https://www.cbsnews.com/sacramento/tag/death/

Death on Everest. On the podcast: An American mountaineer describes the dangers of climbing the worlds tallest peak.. By Dan ...

https://foreignpolicy.com/2019/08/30/death-everest-woody-hartman-himalayas/?tpcc=onboarding_trending

The annual list of the most common causes of death in the United States, compiled by the Centers for Disease Control and Prevention (CDC), informs public awareness and national research priorities each year. (bmj.com)
Federal regulations require that all deaths aboard commercial flights and ships destined for the United States be reported to the Centers for Disease Control and Prevention (CDC). (cdc.gov)

According to an expert from an entry in the Register of Deaths, Her Majesty died on September 8, 2022 at 3:10 PM at Balmoral Castle in Scotland at the age of 96. (yahoo.com)
Rapport d'activités 2022 de l'OMS Niger : principaux résultats de l'OMS atteints en étroite collaboration avec le Gouvernement, les partenaires et d'autres acteurs. (who.int)
A Woman With AF After Husband's Death, Grandkids' Drug Abuse - Medscape - Nov 16, 2022. (medscape.com)

About 697,000 people in the United States died from heart disease in 2020-that's 1 in every 5 deaths . (cdc.gov)
In 2020, about 2 in 10 deaths from CAD happen in adults less than 65 years old. (cdc.gov)
Below are the percentages of all deaths caused by heart disease in 2020, listed by ethnicity, race, and sex. (cdc.gov)
COVID was New Jersey's 2nd leading cause of death overall in 2020. (nj.gov)
Graph of daily death counts due to COVID-19 and other causes of death for 2020 compared to average daily death counts for 2015-2019. (nj.gov)

The death penalty is a contentious topic among many legal minds in India. (theleaflet.in)
But why is society so fascinated with the imposition of the death penalty. (theleaflet.in)
The death penalty is less about the victim of an incident and is a lot more about the social ramifications of the crime. (theleaflet.in)
The death penalty does not. (theleaflet.in)
Connecticut Gov. Dannel Malloy signed the state's death penalty repeal bill into law today, but the new law will not affect the 11 convicted killers already on death row including the two men who killed the wife and daughters of Dr. William Petit . (go.com)
The bill signing made Connecticut the 17th state to abolish the death penalty. (go.com)
This afternoon I signed legislation that will, effective today, replace the death penalty with life in prison without the possibility of release as the highest form of legal punishment in Connecticut,' Malloy said in a statement released after he signed the bill behind closed doors. (go.com)
The new law replaces the death penalty with a sentence of life without parole. (go.com)
It abolished the death penalty for future cases, but it does not affect sentences for the 11 inmate's currently on death row in the state. (go.com)
The second factor that led to his decision today was the 'unworkability' of Connecticut's death penalty law. (go.com)
Malloy also acknowledged that the campaign to abolish the death penalty was led by dozens of family members of murder victims, some of whom were present when he signed the bill. (go.com)
Not all family members have been supportive of repealing the death penalty. (go.com)
One of the strongest voices against repealing the death penalty has been Dr. William Petit Jr., the lone survivor of a 2007 Cheshire home invasion that resulted in the murders of his wife and two daughters. (go.com)
There can, however, be adequate and just punishment and that is the death penalty. (go.com)
In light of the gruesome rape and murder of Anene Booysen and the pandemic of rapes and murders including babies and young children citizens of SA call on the Government to implement the death penalty for this abomination. (ipetitions.com)
The Supreme Court granted certiorari in another death penalty appeal this week. (findlaw.com)
Prosecutors, however, say mental competency isn't necessary for the appeals process to continue, and to conclude otherwise would delay Carter's death penalty appeal indefinitely. (findlaw.com)
Sean Carter's case isn't the first Ohio death penalty the Court will consider this year. (findlaw.com)
As a result, multiple jurors were struck from the pool by the state and the court who were in opposition to the death penalty. (wsws.org)
Skinner's case became an international cause célèbre in anti-death penalty circles after Chicago journalism students found new witnesses and pointed to evidence that had not been DNA tested. (chron.com)

Recommendations are made by the National Institute for Occupational Safety and Health (NIOSH) in a new report to prevent the risk of injury, illness, and death in training dives that prepare firefighters for search, rescue, recovery, and other missions that may entail diving. (cdc.gov)

In January, the Sixth Circuit Court of Appeals ruled that federal courts must monitor every Ohio execution "because the State cannot be trusted to fulfill its otherwise lawful duty to execute inmates sentenced to death. (findlaw.com)
A study published in the Journal of Forensic Sciences in 2002 showed that the suicide rate of death row inmates between 1976 and 1999 was 113 per 100,000-10 times the rate of suicide in the United States as a whole and six times the rate of suicide in the general US prison population. (wsws.org)

99, accounting for 37% of maternal deaths firmed by chest X-ray. (who.int)
However, delay in deciding to seek professional care, delay in reaching a medical centre, and once there, delay in getting the needed care also contribute to maternal deaths. (who.int)
The state of health systems, which are largely weak in Africa, is also a key contributor to high maternal deaths. (who.int)

1 As a result, causes of death not associated with an ICD code, such as human and system factors, are not captured. (bmj.com)
Other causes of death speculated over the years included theories that Gagarin suffered from oxygen deprivation or that perhaps he crashed into another airplane. (ibtimes.com)
In this paper we describe the origins and composition of the Swedish cause of death register, set out the key strengths and weaknesses of the register, and present the main causes of death across age groups and over time in Sweden. (nih.gov)
The Center for Health Statistics maintains mortality data for all causes of death. (nj.gov)
Tables of leading causes of death by age, race/ethnicity, sex, nativity, place and month of death, and county of residence, based on final death counts as of 4/21/22. (nj.gov)
Average daily death count in the last few years due to selected causes of death. (nj.gov)
Use to compare daily COVID-19 death counts to the typical number of daily deaths from heart disease, cancer, car crashes, influenza, and other causes of death. (nj.gov)

Maternal mortality in Mauritania is among the highest in Africa, with 766 deaths for every 100,000 live births. (who.int)

For example, in Wisconsin, at least 141 African Americans have died, representing 27% of all deaths in a state where just 6% of the state's population is black. (npr.org)

Sudden infant death syndrome (SIDS) is the sudden, unexplained death of an infant younger than one year old. (medlineplus.gov)

Is the Hilsa Fish Being Eaten to Death? (worldatlas.com)

Before her death in 1996, Mitford had all but put the finishing touches on an updated account of the funeral industry, which has now been published. (christianitytoday.com)

The limited data that exist suggest that the number of deaths caused by iatrogenic harm outside of hospitals is roughly equal to the number that occur inside hospitals. (statnews.com)
Most SIDS deaths occur when babies are between one month and four months old. (medlineplus.gov)
Most deaths in developed countries occur in people aged over 65, but relatively little health policy is directed at their needs in the last years of life. (who.int)
The basic feature of a second-to-die life insurance policy is that two deaths must occur before the death benefit is paid. (seniormag.com)

As in other types of personal injury lawsuits, in a successful wrongful death case the defendant's liability is expressed solely in terms of financial compensation ("damages") that the court orders the defendant to pay to the deceased person's survivors or estate. (nolo.com)
In Massachusetts, though, only the executor or administrator of the deceased person's estate can file the wrongful death claim. (nolo.com)
The executor or administrator is typically the person named in the deceased person's will (or appointed by the court if the person left no will) who is responsible for paying the deceased person's final debts, wrapping up the estate-and handling any wrongful death claim. (nolo.com)
In a successful wrongful death case, " damages "-or the plaintiff's claimed losses-are awarded to the deceased person's family to compensate them for the death. (nolo.com)

For details, see Guidance for Airlines on Reporting Onboard Deaths or Illnesses to CDC and Guidance for Cruise Ships: How to Report Onboard Death or Illness to CDC . (cdc.gov)
It is the latest in a series of NIOSH "Workplace Solutions" documents that provide practical recommendations for preventing work-related injuries, illnesses, and deaths, based on results of NIOSH research and other authoritative sources. (cdc.gov)

Here's a look at his career and net worth at the time of his death in 2017. (bing.com)

Objective: To describe the profile of deaths in the elderly from external causes in Recife, Pernambuco, in the period 2002 to 2007. (bvsalud.org)

The cause of death was suicide by hanging, authorities stated, and a rep for the actor confirmed the tragic news, saying the Oscar-winning actor had been "battling severe depression of late. (yahoo.com)
Shira Shafir] While coccidioidomycosis has the potential to be severe and fatal, we believe that the number of deaths in the US associated with this disease are limited. (cdc.gov)
In some populations, we suspect that possibility of death increases because poor access to health care services might delay diagnosis, resulting in more severe disease. (cdc.gov)
To reduce the risk of hospital death in severe road traffic injuries , it is important to ensure rapid and medicalized referral of severe trauma patients in Benin . (bvsalud.org)

The spokesman for the Metropolitan Transport Authority, (AMET)Lieutenant Colonel Diego Pesqueira, said Sunday that the traffic policeforce is satisfied at the reduction in the number of traffic accidents andviolent deaths during the Christmas and New Year holidays. (dominicantoday.com)
Accidents were responsible for most deaths. (bvsalud.org)
Road traffic accidents are the leading cause of death by trauma . (bvsalud.org)
Information about deaths related to cataclysmic causes, particularly victims of storms and floods, and maritime accidents in the Philippines during the study period were reviewed and compared with the PHS drowning death data. (who.int)
An average of 4196 drowning deaths were recorded from 1980 to 2011 (range 1220 to 8788) when catacylsmic events and maritime accidents were combined with PHS data. (who.int)
Our results showed that on average there were 1700 more drowning deaths per year when deaths caused by cataclysms and maritime accidents were added to the PHS data. (who.int)
Additionally, deaths due to flooding, storms and maritime accidents are not counted as drowning deaths, which further contributes to the underestimation. (who.int)

He has since returned to Chillicothe, but former District Judge Peter Economus dismissed prosecutors' filing to have Carter returned to death row due to Carter's mental condition. (findlaw.com)
Prosecutors allege that Larkin bludgeoned his parents to death in April of that year. (wsws.org)

Percentages of all deaths caused by heart disease in 2015 by ethnicity, race, and sex. (cdc.gov)
in total, race or ethnicity is known for around half of all cases and 90% of deaths. (npr.org)
This analysis compares each racial or ethnic group's share of infections or deaths - where race and ethnicity is known - with their share of population. (npr.org)

The National Institute for Occupational Safety and Health (NIOSH) requests assistance in preventing silicosis and deaths in construction workers exposed to respirable crystalline silica. (cdc.gov)

Studies to determine the incidence of errors leading to injuries and deaths in hospitals began in the early 1970s. (statnews.com)

The actor shared that her death helped him to find religion and cultivate "a relationship with God. (vanityfair.com)

The Court put a hold on Virginia death-row inmate Melvin Davis Rees, Jr in 1967, and never returned to it. (findlaw.com)
Gregory David Larkin, a 41-year-old death row inmate, was found dead in his cell at Florida State Prison in Bradford County on the morning of May 27. (wsws.org)
Larkin is the fourth inmate on Florida's death row to commit suicide since 2000. (wsws.org)

Of course, Congress could always act to extend the repeal beyond 2010, but a more realistic question is whether opponents of the whole idea of repeal of the 'death tax' might be successful before then in overturning the main provisions of the law. (seniormag.com)

Tributes have been paid following the death of EastEnders legend Bill Treacher, who has died at the age of 92. (bing.com)

Major holes in the data remain: 48% of cases and 9% of deaths still have no race tied to them. (npr.org)
The Taliban courts employ strict interpretations of Shari'a law, which prescribes death, or in other cases publicly flogging, for men or women found guilty of having a relationship outside marriage. (rferl.org)
The World Health Organization concurs, saying that bodies "only pose a substantial risk to health in a few special cases, such as deaths from cholera or hemorrhagic fevers. (mentalfloss.com)
The overall number of global coronavirus cases has surpassed 300 million, while the deaths have surged to more than 5.47 million and vaccinations to over 9.33 billion,, according to the Johns Hopkins. (dailynews.lk)
Distribution of discharged and death cases in different age groups. (cdc.gov)
Assistance can begin exactly in the moment the death is communicated by the physician, in some cases. (bvsalud.org)
Numbers of cases and deaths are attributed to broad categories of causal factors for use in public health planning. (who.int)

The science of safety has matured to describe how communication breakdowns, diagnostic errors, poor judgment, and inadequate skill can directly result in patient harm and death. (bmj.com)
The scene above exemplifies what many people who have had a near-death experience (NDE) describe. (medscape.com)
To describe aspects of the experience of the Clinic Psychology Service of a reference hospital in cardiology in RS concerning the assistance given to family members during the moment of death of children attended to at Pediatric Units. (bvsalud.org)
A retrospective descriptive study was conducted to describe the trend of deaths caused by drowning in the Philippines from official and unofficial sources in the period 1980 to 2011. (who.int)

What is the Hindi language plot outline for Death Wish (2018)? (imdb.com)

Damages can also be awarded for "conscious suffering" experienced by the deceased as a result of the illness or injury that caused the death. (nolo.com)

Heart disease is the leading cause of death for men, women, and people of most racial and ethnic groups in the United States. (cdc.gov)
Heart disease is the leading cause of death for people of most racial and ethnic groups in the United States, including African American, American Indian, Alaska Native, Hispanic, and white men. (cdc.gov)
After lying in state at Westminster Hall, the United Kingdom and people from around the world mourned her death and celebrated her historoc 70 years on the throne. (yahoo.com)
A Dallas man was arrested in the slayings of three people, including the high-profile death of transgender woman Muhlaysia Booker , Dallas Police said Wednesday. (cnn.com)
The state has put to death two people in the past 52 years and both had volunteered for it. (go.com)
Some people call SIDS "crib death" because many babies who die of SIDS are found in their cribs. (medlineplus.gov)
Your assistance in this effort will help prevent silicosis-related death and disease, a national goal for health promotion and disease prevention stated in Healthy People 2000 [PHS 1990]. (cdc.gov)
People over the age of 65 may be at increased risk for death because their immune systems do not function as well and also because they are more likely to have other medical conditions. (cdc.gov)
Unfortunately, many people believe the sound bites that have pronounced the death of the death tax . (seniormag.com)
The study also shows that people treated in the ER for a sedative overdose are at a higher risk of death by overdose or suicide, too. (medlineplus.gov)
Actions like providing resources and referring people to mental health professionals can help reduce the risk of death by overdose or suicide. (medlineplus.gov)

A 2013 meta-analysis of Global Trigger studies found 10 times as many adverse events as found by conventional records reviews, with deaths numbering as many as 440,000 per year. (statnews.com)
SIDS is the leading cause of death in children between one month and one year old. (medlineplus.gov)
Surrey residents are reeling after an 18-year-old was stabbed to death on the grounds of a local high school Tuesday. (bing.com)
Guillotine' is a single released by the experimental hip-hop group Death Grips on April 27, 2011 to promote the 'Exmilitary' mixtape they released that year. (last.fm)
Nearly six months after Harrison Wagner, the 27-year-old son of General Hospital stars Jack and Kristina Wagner, was found dead in Los Angeles, officials have determined his cause of death. (yahoo.com)
In October, 19-year-old Rokhsana was stoned to death by Taliban militants in the same province after having been accused of having premarital sex. (rferl.org)
Data tables and graph of monthly total death counts by county of residence for each year. (nj.gov)
Sheykhzadeh's death is at least the second on Humphreys this year. (mercurynews.com)
Similar to the death of a close family member, this process will take about a year to finally achieve. (psychcentral.com)
Over an 18-year period, about 3,100 deaths related to this disease occurred. (cdc.gov)
He said that the number of traffic accident deaths was down 13%compared with the Christmas and New Year period in 2014-2015. (dominicantoday.com)
A Port St. Lucie man faces a first-degree murder charge in the death of his 2-year-old foster child. (wpbf.com)
An average of 2496 deaths per year caused by drowning were recorded in the PHS reports from 1980 to 2011 (range 671-3656). (who.int)

If a crime must warrant death, then society must be the murderer to carry out that sentence. (theleaflet.in)
The aim of punishment is reformative, otherwise everyone would get th death sentence for the smallest of crimes. (theleaflet.in)

William T. Newland Elementary SchoolThis article has been corrected to reflect that Christopher Christensen had pleaded not guilty before his death. (yahoo.com)

We have no news for Death Dome . (gamespot.com)
Alexander Stepanov, the Kremlin's top archives official told a news conference that a Soviet investigation commission from that era determined this was the most likely cause of the hero's death. (ibtimes.com)
First, news of Chevy Chase's death was noticeably absent from all major publications on 5 January 2016. (snopes.com)

The Times recently began using C.D.C. data based on death certificates for locations that do not report deaths regularly or comprehensively. (nytimes.com)
The federal data updates approximately once a month, which may appear as a spike in deaths. (nytimes.com)
Sweden has a long tradition of recording cause of death data. (nih.gov)
This paper provides a guide and reference to individuals and organisations interested in data from the Swedish cause of death register. (nih.gov)
The source of the data is death certificates. (nj.gov)
Use NJSHAD to create custom tabulations of New Jersey resident death certificate data. (nj.gov)
The source for all data linked below is death certificates. (nj.gov)
US Fetal death data are limited to deaths occurring within the United States to U.S. residents and nonresidents. (cdc.gov)
Fetal deaths occurring to U.S. citizens outside the United States are not included in this data file. (cdc.gov)
Fetal death data for Puerto Rico, Virgin Islands, and Guam are limited to deaths occurring within the respective territories. (cdc.gov)
Multiple Cause of Death 1999-2013 from CDC WONDER Online Database, 2013 United States Renal Data System. (cdc.gov)
For the study, researchers analyzed data from emergency departments in California from 2009 to 2011 and on deaths in the state during that time period. (medlineplus.gov)
This illustrated that drowning deaths were underestimated in the official surveillance data. (who.int)

Western near-death experiences are the most studied. (theatlantic.com)

The Riverside County Sheriff's Department release details about the death of comedian Teddy Ray. (yahoo.com)

Providing resources to opioid overdose patients in the ER can help reduce the risk of death by overdose or suicide. (medlineplus.gov)

3 This includes the cost of health care services, medicines, and lost productivity due to death. (cdc.gov)
Sarah Palin's Prediction of Bleak Health-Care Dystopia Widely Mocked But what if her claims of Obama's "death panels" are true? (nymag.com)
This study aims to determine if the drowning death rates in the Philippine Health Statistics (PHS) reports from 1980 to 2011 were underestimated. (who.int)

That's more than enough to make medical care gone awry the number three cause of death in the U.S., after heart disease and cancer. (statnews.com)
Sally Ride's Death: Why is Pancreatic Cancer So Deadly? (livescience.com)

Results: Death from external causes predominated in males with brown skin, aged 75 years or over. (bvsalud.org)

Nationally, African-American deaths from COVID-19 are nearly two times greater than would be expected based on their share of the population. (npr.org)
White deaths from COVID-19 are lower than their share of the population in 37 states and the District of Columbia. (npr.org)
Meroro, the patient with the longest hospital admission for COVID-19 at Gobabis State hospital narrowly escaped death. (who.int)

This can clearly be seen from the fact that, even after the convicts were sentenced to death and the rape laws were toughened, incidents continue happening. (theleaflet.in)

Medical error is not included on death certificates or in rankings of cause of death. (bmj.com)
The list is created using death certificates filled out by physicians, funeral directors, medical examiners, and coroners. (bmj.com)

HOUSTON - Two men have been arrested - including one facing a murder charge - in the shooting death of Migos rapper Takeoff, police announced Friday. (wftv.com)

However, a major limitation of the death certificate is that it relies on assigning an International Classification of Disease (ICD) code to the cause of death. (bmj.com)
Sudden cardiac death (SCD) is an unexpected death due to cardiac causes that occurs in a short time period (generally within 1 hour of symptom onset) in a person with known or unknown cardiac disease. (medscape.com)
The number of deaths with diabetes as UCD corresponds to death certificate reports where diabetes was ascertained to be the disease that initiated the chain of morbid events that led directly and inevitably to death. (cdc.gov)

Get documentation of the emergency such as a death certificate, statement from a mortuary, or a letter from the hospital (on hospital/clinic letterhead, signed by the doctor/medical professional, explaining your relative's medical condition). (state.gov)
Examples include a death certificate, statement from the mortuary, or letter from the hospital. (state.gov)
A TOD Beneficiary designation that is printed on an Indiana Certificate of Title is not valid unless the vehicle owner(s) had signed the TOD statement prior to their death. (in.gov)
A TOD Beneficiary who has acquired ownership of a vehicle, as a result of being listed on the vehicle's Indiana Certificate of Title as a TOD beneficiary, must take the Indiana title containing the TOD designation and a copy of the decedent's death certificate to a BMV license branch to apply for a new Indiana title. (in.gov)
this according to the death certificate obtained by TMZ. (tmz.com)
The death certificate also states there were no other significant conditions contributing to his death. (tmz.com)
Well, it seems TMZ have shared a copy of Lemmy's death certificate. (metalsucks.net)

These increases have not yet extended as significantly to deaths. (nytimes.com)
Rather than use such tax-sheltering devices, they may prefer to leave everything to each other outright, even if this increases the estate taxes due upon the second death. (seniormag.com)

Watch what happens as the brain gets closer and closer to death. (medscape.com)

Conclusion: Although the number of deaths from external causes among the elderly continued to rise throughout the period studied, there was a substantial decline in 2007 that requires further investigation to confirm the falling trend observed. (bvsalud.org)

Both victims were shot to death, one on May 22 and the other on May 23. (cnn.com)
Disaster response officials believe the final death toll from the huge wave that pummeled the Mentawai island chain off the west coast of Sumatra Monday could exceed 600, with many victims sucked out to sea as the tsunami receded. (nbcnews.com)

A common place is the lung, where the clot can cause a cough, shortness of breath, pain while taking deep breaths, chest pain, and even death. (medlineplus.gov)

This is one major difference between a wrongful death lawsuit and a criminal homicide case, where a conviction can result in jail or prison time, fines paid to the state, probation, and other penalties. (nolo.com)
Another big difference between a criminal prosecution for homicide and a wrongful death civil lawsuit: In criminal court, the state or federal government must establish the accused person's guilt "beyond a reasonable doubt"-a very high bar for the prosecution to clear. (nolo.com)

In The American Way of Death Revisited , Mitford suggests that those dying at the end of the twentieth century will be no better off than those who died 40 years before. (christianitytoday.com)
While the incident happened two years ago, the findings of an investigation now say there is nothing that could have been done to prevent the deaths. (cbc.ca)
No death in recent years has so galvanized public opinion here. (frontlineclub.com)

Can the Democrats Get Ahead of the 'Death Panel' Myth This Time Around? (nymag.com)
What Was Bill Paxton's Net Worth at the Time of His Death? (bing.com)
An experiment in estimating the time of death was performed where a potato was used instead of a human body. (uncw.edu)
The time of death for the potato was considered to be the time it was taken out of the oven. (uncw.edu)
The temperature of the potato at the time of death was 194 F. Temperature readings of the potato were taken every fifteen minutes for three hours. (uncw.edu)
Newton's Law of Cooling states that the rate of cooling of an object is proportional to the temperature difference between the object and its surroundings, provided that this difference is not too large.1 When estimating the time of death, one needs to know the temperature of the surroundings and the temperature of the body at two different times in order to make an accurate estimate. (uncw.edu)
is the ambient temperature, and time t is the number of hours since the time of death. (uncw.edu)
Assume that the temperature of the potato is 194 F at the time of death so that T(0) = 194 F. Make sure the temperature of the apartment is kept constant during the experiment. (uncw.edu)
Estimate the time of death of the potato for every corresponding temperature and compare these estimates with the true values. (uncw.edu)

Geron said Lyles is also a person of interest in the death of Chynal Lindsey , whose body was found in a lake less than two weeks after Booker's death. (cnn.com)

Prison officials listed the cause of death as asphyxiation but did not provide further details. (wsws.org)

Anatomy16

Organisms6

Diseases38

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Psychiatry and Psychology5

Phenomena and Processes44

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena6

Information Science21

Named Groups2

Health Care48

Geographicals8

The expiry date of man: a synthesis of evolutionary biology and public health. (1/646)

The case for a statutory 'definition of death'. (2/646)

beta2-adrenergic receptor-selective agonist clenbuterol prevents Fas-induced liver apoptosis and death in mice. (3/646)

Antitumor and immunotherapeutic effects of activated invasive T lymphoma cells that display short-term interleukin 1alpha expression. (4/646)

Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. (5/646)

Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice. (6/646)

Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice. (7/646)

Does hospital at home for palliative care facilitate death at home? Randomised controlled trial. (8/646)

Cell Death

Cause of Death

Death

Death, Sudden, Cardiac

Brain Death

Fetal Death

Attitude to Death

Caspases

Apoptosis

Receptors, Death Domain

Cell Survival

Time Factors

Risk Factors

Mortality

Autopsy

Caspase 3

Necrosis

Follow-Up Studies

Proto-Oncogene Proteins c-bcl-2

Retrospective Studies

Signal Transduction

Antigens, CD95

Mitochondria

Infant, Newborn

DNA Fragmentation

Treatment Outcome

Survival Analysis

Cell Line, Tumor

Caspase Inhibitors

Cells, Cultured

Prospective Studies

Autophagy

In Situ Nick-End Labeling

Caspase 8

Infant Mortality

Death Domain Receptor Signaling Adaptor Proteins

Cohort Studies

BH3 Interacting Domain Death Agonist Protein

Neurons

United States

bcl-2-Associated X Protein

Prognosis

Survival Rate

Reactive Oxygen Species

Neoplasms

Risk Assessment

Age Factors

Caspase 9

Fas Ligand Protein

Enzyme Activation

Incidence

Cell Line

Amino Acid Chloromethyl Ketones

Homicide

Myocardial Infarction

Registries

Mice, Inbred C57BL

Suicide

Cytochromes c

Pregnancy

Maternal Mortality

Cysteine Proteinase Inhibitors

Kaplan-Meier Estimate

Poly(ADP-ribose) Polymerases

bcl-X Protein

bcl-Associated Death Protein

Blotting, Western

Risk

Mutation

Wounds and Injuries

Mice, Knockout

Programmed Cell Death 1 Receptor

Life Expectancy

Dose-Response Relationship, Drug

Cardiovascular Diseases

Disease Models, Animal

Antineoplastic Agents

Receptors, TNF-Related Apoptosis-Inducing Ligand

TNF-Related Apoptosis-Inducing Ligand

Tumor Cells, Cultured