Cell Death: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.Cause of Death: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.Death: Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)Brain Death: A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.Attitude to Death: Conceptual response of the person to the various aspects of death, which are based on individual psychosocial and cultural experience.Caspases: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Receptors, Death Domain: A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a death domain due to the fact that many of these receptors are involved in signaling APOPTOSIS. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Mortality: All deaths reported in a given population.Autopsy: Postmortem examination of the body.Caspase 3: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Necrosis: The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Proto-Oncogene Proteins c-bcl-2: Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Antigens, CD95: A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.Mitochondria: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)Infant, Newborn: An infant during the first month after birth.DNA Fragmentation: Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Cell Line, Tumor: A cell line derived from cultured tumor cells.Caspase Inhibitors: Endogenous and exogenous compounds and that either inhibit CASPASES or prevent their activation.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Autophagy: The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.In Situ Nick-End Labeling: An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.Caspase 8: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.Infant Mortality: Postnatal deaths from BIRTH to 365 days after birth in a given population. Postneonatal mortality represents deaths between 28 days and 365 days after birth (as defined by National Center for Health Statistics). Neonatal mortality represents deaths from birth to 27 days after birth.Death Domain Receptor Signaling Adaptor Proteins: Intracellular signaling adaptor proteins that bind to the cytoplasmic death domain region found on DEATH DOMAIN RECEPTORS. Many of the proteins in this class take part in intracellular signaling from TUMOR NECROSIS FACTOR RECEPTORS.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.BH3 Interacting Domain Death Agonist Protein: A member of the Bcl-2 protein family that reversibly binds MEMBRANES. It is a pro-apoptotic protein that is activated by caspase cleavage.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.United Statesbcl-2-Associated X Protein: A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Reactive Oxygen Species: Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Caspase 9: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.Fas Ligand Protein: A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Amino Acid Chloromethyl Ketones: Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.Homicide: The killing of one person by another.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Mice, Inbred C57BLSuicide: The act of killing oneself.Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Maternal Mortality: Maternal deaths resulting from complications of pregnancy and childbirth in a given population.Cysteine Proteinase Inhibitors: Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Poly(ADP-ribose) Polymerases: Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.bcl-X Protein: A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.bcl-Associated Death Protein: A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad protein inhibits the activity of BCL-XL PROTEIN.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Risk: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Programmed Cell Death 1 Receptor: An inhibitory T-lymphocyte receptor that has specificity for CD274 ANTIGEN and PROGRAMMED CELL DEATH 1 LIGAND 2 PROTEIN. Signaling by the receptor limits T cell proliferation and INTERFERON GAMMA synthesis. The receptor also may play an essential role in the regulatory pathway that induces PERIPHERAL TOLERANCE.Life Expectancy: Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Receptors, TNF-Related Apoptosis-Inducing Ligand: Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved death domains that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.TNF-Related Apoptosis-Inducing Ligand: A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Vital Statistics: Used for general articles concerning statistics of births, deaths, marriages, etc.Membrane Potential, Mitochondrial: The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Hospitalization: The confinement of a patient in a hospital.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Receptors, Tumor Necrosis Factor: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.Asphyxia: A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Jurkat Cells: A CELL LINE derived from human T-CELL LEUKEMIA and used to determine the mechanism of differential susceptibility to anti-cancer drugs and radiation.RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.EnglandPopulation Surveillance: Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.Hydrogen Peroxide: A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.Terminal Care: Medical and nursing care of patients in the terminal stage of an illness.Bereavement: Refers to the whole process of grieving and mourning and is associated with a deep sense of loss and sadness.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Neuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Receptor-Interacting Protein Serine-Threonine Kinases: A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Mortality, Premature: Deaths that occur before LIFE EXPECTANCY is reached within a given population.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Accidents, Traffic: Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.Cytoprotection: The process by which chemical compounds provide protection to cells against harmful agents.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.bcl-2 Homologous Antagonist-Killer Protein: A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.Annexin A5: A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.WalesCoronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Wounds, Gunshot: Disruption of structural continuity of the body as a result of the discharge of firearms.TNF Receptor-Associated Death Domain Protein: A 34 kDa signal transducing adaptor protein that associates with TUMOR NECROSIS FACTOR RECEPTOR TYPE 1. It facilitates the recruitment of signaling proteins such as TNF RECEPTOR-ASSOCIATED FACTOR 2 and FAS ASSOCIATED DEATH DOMAIN PROTEIN to the receptor complex.Poisoning: A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.JNK Mitogen-Activated Protein Kinases: A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.Recurrence: The return of a sign, symptom, or disease after a remission.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Inhibitor of Apoptosis Proteins: A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.Caspase 1: A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Caspase 2: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Forensic Pathology: The application of pathology to questions of law.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Stillbirth: The event that a FETUS is born dead or stillborn.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Lung Neoplasms: Tumors or cancer of the LUNG.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Animals, Newborn: Refers to animals in the period of time just after birth.Caspase 7: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 3 and CASPASE 10. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Propidium: Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.Cysteine Endopeptidases: ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.RNA Interference: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.NF-kappa B: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Great BritainCell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Epidemiologic Methods: Research techniques that focus on study designs and data gathering methods in human and animal populations.Odds Ratio: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Apoptotic Protease-Activating Factor 1: A CARD signaling adaptor protein that plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY). It binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX and activates INITIATOR CASPASES such as CASPASE 9.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Breast Neoplasms: Tumors or cancer of the human BREAST.Staurosporine: An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)Cytochrome c Group: A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Genes, bcl-2: The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.Neurotoxins: Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Acute Disease: Disease having a short and relatively severe course.Protein-Serine-Threonine Kinases: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.Life Tables: Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.JapanCalcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Comorbidity: The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.Calpain: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesDNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Receptors, Tumor Necrosis Factor, Type I: A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Child Mortality: Number of deaths of children between one year of age to 12 years of age in a given population.SwedenChi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Microtubule-Associated Proteins: High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.Grief: Normal, appropriate sorrowful response to an immediate cause. It is self-limiting and gradually subsides within a reasonable time.Perinatal Mortality: Deaths occurring from the 28th week of GESTATION to the 28th day after birth in a given population.Proto-Oncogene Proteins c-akt: A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.

The expiry date of man: a synthesis of evolutionary biology and public health. (1/646)

In industrialised countries, mortality and morbidity are dominated by age related chronic degenerative diseases. The health and health care needs of future populations will be heavily determined by these conditions of old age. Two opposite scenarios of future morbidity exist: morbidity might decrease ("compress"), because life span is limited, and the incidence of disease is postponed. Or morbidity might increase ("expand"), because death is delayed more than disease incidence. Optimality theory in evolutionary biology explains senescence as a by product of an optimised life history. The theory clarifies how senescence is timed by the competing needs for reproduction and survival, and why this leads to a generalised deterioration of many functions at many levels. As death and disease are not independent, future morbidity will depend on duration and severity of the process of senescence, partly determined by health care, palliating the disease severity but increasing the disease duration by postponing death. Even if morbidity might be compressed, health care needs will surely expand.  (+info)

The case for a statutory 'definition of death'. (2/646)

Karen Quinlan, the American girl who has lain in deep coma for many months, is still 'alive', that is to say, her heart is still beating and brain death has not occurred. However, several other cases have raised difficult issues about the time of death. Dr Skegg argues that there is a case for a legal definition of death enshrined in statutory form. He suggests that many of the objections to a statutory provision on death are misplaced, and that a statute concerning the occurrence of death could remove all doubts in the minds of both doctors and public as to whether a 'beating heart cadaver' was dead or alive for legal purposes.  (+info)

beta2-adrenergic receptor-selective agonist clenbuterol prevents Fas-induced liver apoptosis and death in mice. (3/646)

Stimulation of the cAMP-signaling pathway modulates apoptosis in several cell types and inhibits Jo2-mediated apoptosis in cultured rat hepatocytes. No information is yet available as to whether the hepatic beta2-adrenergic receptor (AR) expression level, including beta2-AR-dependent adenylyl cyclase activation, modulates hepatocyte sensitivity to apoptosis in vivo or whether this sensitivity can be modified by beta2-AR ligands. We have examined this using C57BL/6 mice, in which hepatic beta2-AR densities are low, and transgenic F28 mice, which overexpress beta2-ARs and have elevated basal liver adenylyl cyclase activity. The F28 mice were resistant to Jo2-induced liver apoptosis and death. The beta-AR antagonist propranolol sensitized the F28 livers to Jo2. In normal mice clenbuterol, a beta2-AR-specific agonist, considerably reduced Jo2-induced liver apoptosis and death; salbutamol, another beta2-AR-selective agonist, also reduced Jo2-induced apoptosis and retarded death but with less efficacy than clenbuterol; and propranolol blocked the protective effect of clenbuterol. This indicates that the expression level of functional beta2-ARs modulates Fas-regulated liver apoptosis and that this apoptosis can be inhibited in vivo by giving beta2-AR agonists. This may well form the basis for a new therapeutic approach to diseases involving abnormal apoptosis.  (+info)

Antitumor and immunotherapeutic effects of activated invasive T lymphoma cells that display short-term interleukin 1alpha expression. (4/646)

Expression of cytokines in malignant cells represents a novel approach for therapeutic treatment of tumors. Previously, we demonstrated the immunostimulatory effectiveness of interleukin 1alpha (IL-1alpha) gene transfer in experimental fibrosarcoma tumors. Here, we report the antitumor and immunotherapeutic effects of short-term expression of IL-1alpha by malignant T lymphoma cells. Activation in culture of T lymphoma cells with lipopolysaccharide-stimulated macrophages induces the expression of IL-1alpha. The short-term expression of IL-1alpha persists in the malignant T cells for a few days (approximately 3-6 days) after termination of the in vitro activation procedure and, thus, has the potential to stimulate antitumor immune responses in vivo. As an experimental tumor model, we used the RO1 invasive T lymphoma cell line. Upon i.v. inoculation, these cells invade the vertebral column and compress the spinal cord, resulting in hind leg paralysis and death of the mice. Activated RO1 cells, induced to express IL-1alpha in a short-term manner, manifested reduced tumorigenicity: approximately 75% of the mice injected with activated RO1 cells remained tumor free. IL-1 was shown to be essential for the eradication of activated T lymphoma cells because injection of activated RO1 cells together with IL-1-specific inhibitors, i.e., the IL-1 receptor antagonist or the M 20 IL-1 inhibitor, reversed reduced tumorigenicity patterns and led to progressive tumor growth and death of the mice. Furthermore, activated RO1 cells could serve as a treatment by intervening in the growth of violent RO1 cells after tumor take. Thus, when activated RO1 cells were injected 6 or 9 days after the inoculation of violent cells, mortality was significantly reduced. IL-1alpha, in its unique membrane-associated form, in addition to its cytosolic and secreted forms, may represent a focused adjuvant for potentiating antitumor immune responses at low levels of expression, below those that are toxic to the host. Further assessment of the immunotherapeutic potential of short-term expression of IL-1alpha in activated tumor cells may allow its improved application in the treatment of malignancies.  (+info)

Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. (5/646)

In most cells, the ubiquitously expressed Na+/H+ exchanger isoform 1 (NHE1) is thought to be a primary regulator of pH homeostasis, cell volume regulation, and the proliferative response to growth factor stimulation. To study the function of NHE1 during embryogenesis when these cellular processes are very active, we targeted the Nhe1 gene by replacing the sequence encoding transmembrane domains 6 and 7 with the neomycin resistance gene. NHE activity assays on isolated acinar cells indicated that the targeted allele is functionally null. Although the absence of NHE1 is compatible with embryogenesis, Nhe1 homozygous mutants (-/-) exhibit a decreased rate of postnatal growth that is first evident at 2 wk of age. At this time, Nhe1 -/- animals also begin to exhibit ataxia and epileptic-like seizures. Approximately 67% of the -/- mutants die before weaning. Postmortem examinations frequently revealed an accumulation of a waxy particulate material inside the ears, around the eyes and chin, and on the ventral surface of the paws. Histological analysis of adult tissues revealed a thickening of the lamina propria and a slightly atrophic glandular mucosa in the stomach.  (+info)

Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice. (6/646)

Secreted forms of the beta-amyloid precursor protein (beta-APP) have neuroprotective properties in vitro and may be involved in the containment of neuronal excitation. To test whether loss of secreted forms of beta-APP (sAPPs) may enhance excitotoxic responses, we injected mice homozygous for a targeted mutation of the beta-APP gene (beta-APPDelta/Delta) intraperitoneally with kainic acid. We found that in these mice, kainic acid induced seizures initiated earlier, and acute mortality was enhanced compared to isogenic wild-type mice independently from the callosal agenesis phenotype observed to occur at increased frequency in APP mutant mice. Expression of c-fos in cortex and cingulate gyrus was enhanced in beta-APPDelta/Delta mice, although the amount of structural damage and apoptosis in the hippocampal pyramidal cell layer and cortex was similar to that of controls. When cerebellar granule cell cultures and cortical neuronal cultures were challenged with glutamate receptor agonists, the rates of cell death and apoptosis of beta-APPDelta/Delta mice were indistinguishable from those of controls. Therefore, deficiency of sAPPs causes facilitation of seizure activity in the absence of enhanced cell death. Since enhanced seizures were observed also in mice homozygous for a deletion of the entire beta-APP gene, this phenotype results from a loss of APP rather than from a dominant effect of APPDelta.  (+info)

Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice. (7/646)

Hepatocyte nuclear factors 3 (HNF-3) belong to an evolutionarily conserved family of transcription factors that are critical for diverse biological processes such as development, differentiation, and metabolism. To study the physiological role of HNF-3alpha, we generated mice that lack HNF-3alpha by homologous recombination in embryonic stem cells. Mice homozygous for a null mutation in the HNF-3alpha gene develop a complex phenotype that is characterized by abnormal feeding behavior, progressive starvation, persistent hypoglycemia, hypotriglyceridemia, wasting, and neonatal mortality between days 2 and 14. Hypoglycemia in HNF-3alpha-null mice leads to physiological counter-regulatory responses in glucocorticoid and growth hormone production and an inhibition of insulin secretion but fails to stimulate glucagon secretion. Glucagon-producing pancreatic alpha cells develop normally in HNF-3alpha-/- mice, but proglucagon mRNA levels are reduced 50%. Furthermore, the transcriptional levels of neuropeptide Y are also significantly reduced shortly after birth, implying a direct role of HNF-3alpha in the expression of these genes. In contrast, mRNA levels were increased in HNF-3 target genes phosphofructo-2-kinase/fructose-2,6-bisphophatase, insulin growth factor binding protein-1, and hexokinase I of HNF-3alpha-null mice. Mice lacking one or both HNF-3alpha alleles also show impaired insulin secretion and glucose intolerance after an intraperitoneal glucose challenge, indicating that pancreatic beta-cell function is also compromised. Our results indicate that HNF-3alpha plays a critical role in the regulation of glucose homeostasis and in pancreatic islet function.  (+info)

Does hospital at home for palliative care facilitate death at home? Randomised controlled trial. (8/646)

OBJECTIVE: To evaluate the impact on place of death of a hospital at home service for palliative care. DESIGN: Pragmatic randomised controlled trial. SETTING: Former Cambridge health district. PARTICIPANTS: 229 patients referred to the hospital at home service; 43 randomised to control group (standard care), 186 randomised to hospital at home. INTERVENTION: Hospital at home versus standard care. MAIN OUTCOME MEASURES: Place of death. RESULTS: Twenty five (58%) control patients died at home compared with 124 (67%) patients allocated to hospital at home. This difference was not significant; intention to treat analysis did not show that hospital at home increased the number of deaths at home. Seventy three patients randomised to hospital at home were not admitted to the service. Patients admitted to hospital at home were significantly more likely to die at home (88/113; 78%) than control patients. It is not possible to determine whether this was due to hospital at home itself or other characteristics of the patients admitted to the service. The study attained less statistical power than initially planned. CONCLUSION: In a locality with good provision of standard community care we could not show that hospital at home allowed more patients to die at home, although neither does the study refute this. Problems relating to recruitment, attrition, and the vulnerability of the patient group make randomised controlled trials in palliative care difficult. While these difficulties have to be recognised they are not insurmountable with the appropriate resourcing and setting.  (+info)

  • From 2003 to 2017, the proportion of cardiovascular disease (CVD) deaths that occurred in the hospital decreased, while CVD deaths at home increased, according to a study published in the Oct. 15 issue of the Journal of the American College of Cardiology . (doctorslounge.com)
  • Members of Cookstown Fr Rocks GAA club were "deeply saddened to learn of the sudden death" of an "esteemed member" and former chairman. (tyronetimes.co.uk)
  • In messages on social media this morning the side said: "Cookstown Fr Rocks are deeply saddened to learn of the sudden death of our esteemed member and former chairman Colm O'Neill, Westland Park. (tyronetimes.co.uk)
  • Sarah H. Cross, M.P.H., from Duke University in Durham, North Carolina, and colleagues examined trends and factors associated with the location of death among CVD patients in the United States using the Mortality Multiple Cause-of-Death Public Use Record from 2003 to 2017. (doctorslounge.com)
  • The greatest increases in home deaths occurred among deaths due to ischemic heart disease or hypertensive disorders, while the proportion of patients dying in the hospital decreased for all CVD subtypes except conduction disorders. (doctorslounge.com)
  • During the same period, there was an increase in deaths at home (from 21.3 to 30.9 percent) and in hospice (to 6 percent in 2017). (doctorslounge.com)
  • According to Reuters , the report explains that tobacco is expected to kill 7.5 million people worldwide by 2020, accounting for 10 percent of all deaths. (drugfree.org)
  • Pig brains kept alive outside body for hours after death' and 'Revival of disembodied organs raises slew of ethical and legal questions about the nature of death and consciousness. (dirnagl.com)
  • Home has become the most common place of death for CVD patients, reinforcing the need for more information about the experiences of these patients," the authors write. (doctorslounge.com)
  • Cigarette companies are funding opioid deaths as a diversion to the 500000 people they kill every year just in the us. (drugfree.org)
  • Easy…not only is both a huge money making business, but it also mAkes people sick, leading them to slow deaths making money over the years off their ailments. (drugfree.org)
  • The paper goes on to report that since the Supreme Court reinstated the death penalty in 1976, nationwide eight whites have been executed for killing blacks while 123 blacks have been put to death for killing whites. (slate.com)
  • Three countries have signed treaties to abolish the death penalty, but not have not yet ratified them: Angola, Madagascar, Sao Tome and Principe. (infoplease.com)
  • Jesuit priest and former prison chaplain Father Peter Norden said Australia had a responsibility to pressure other countries to abolish the death penalty. (smh.com.au)
  • Additionally, a bill to abolish the death penalty passed the legislature in 2009, but was vetoed by former Governor Jodie Rell. (ncsl.org)
  • China's top legislature is considering the abolition of the death penalty for a range of non-violent economic crimes. (cnbc.com)
  • China's top legislature said on Monday it was considering the abolition of the death penalty for a range of non-violent economic crimes, including animal smuggling, tax evasion and forgery. (cnbc.com)
  • The ruling blocks the state from proceeding with the executions of the 11 men who remained on death row after the abolition of the death penalty. (ncsl.org)
  • A record cannot be identified as available prior to purchase because under State statute (IC 16-37-1-11 and IC 37-1-11.5), the fee associated with a death certificate is for the ISDH Vital Records office to search the records to determine if a record is on file. (in.gov)
  • Gallbladder cancer is more common among women (1.4 cases and 0.7 deaths per 100,000 women) than men (0.8 cases and 0.5 deaths per 100,000 men). (cdc.gov)
  • American Indian and Alaska Native people had the highest gallbladder cancer incidence and death rates (3.2 cases and 1.6 deaths per 100,000 people). (cdc.gov)
  • These statistics are most often reported as the numbers of new cases of invasive cancer and cancer deaths per year per 100,000 persons in the U.S. population. (cancer.gov)
  • When the statistics focus on cancer incidence and death in a single gender for example, on female breast cancer or male prostate cancer the numbers are per 100,000 persons of that gender. (cancer.gov)
  • The combat-related death gratuity of $100,000 took effect May 11 when the president signed the Emergency Supplemental Wartime Appropriations Act (Public Law 109-13). (military.com)
  • Because the wartime supplemental bill expires on Sept. 30, provisions to make permanent the combat-related death gratuity of $100,000 and SGLI coverage of $400,000 are included in fiscal 2006 defense authorization bills moving through Congress. (military.com)
  • But Bill Vance, Democratic candidate for the Texas Court of Criminal Appeals - who says he favors the death penalty for those who deserve it - contends the appeals system for death row inmates isn't working properly and says appellants aren't getting a fair shake. (law.com)
  • The country last executed prisoners exactly a year earlier, when the conservative Liberal Democratic Party still ruled the country, putting to death three inmates including one Chinese national, also for multiple murder. (smh.com.au)
  • The Connecticut Supreme Court held in a 4-3 decision issued Aug. 13, that the execution of inmates who committed capital felonies before the state abolished the death penalty in 2012 would violate Connecticut's constitutional prohibition against cruel and unusual punishment. (ncsl.org)
  • The law was not applied retroactively, which meant that the 11 inmates were left on death row. (ncsl.org)
  • And Texas, a single state, accounts for nearly a third of all federal death-row inmates. (thenation.com)
  • A cohort of 1981 women not accompanied by dependent children who used homeless shelters in Toronto in 1995 was observed for death over a mean of 2.6 years. (cmaj.ca)
  • This is a significant decrease from 20 years ago in 1995, when there were executions in 42 countries, highlighting the clear global trend of states moving away from the death penalty. (infoplease.com)
  • Nationwide, a study by Columbia University School of Law Professor James Liebman found that 68 percent of death penalty appeals were successful between 1973 and 1995. (law.com)
  • Nel 1995 anche il Live After Death , come tutti gli altri album pubblicati dagli Iron Maiden fino a quel momento, venne ripubblicato in versione doppio CD con le b-side dei singoli inseriti nel secondo CD (per la precisione i brani Losfer Words (Big 'Orra) , Sanctuary e Murders in the Rue Morgue ). (wikipedia.org)
  • Furman v. Georgia (1972): The Supreme Court declared the death penalty unconstitutional, as cruel and unusual punishment in violation of the Eight Amendment, and finding that the administration of the ultimate punishment was arbitrary and capricious. (aclu.org)
  • The reformers in recent years also persuaded the authorities to require Supreme Court approval for all death sentences and to make torture inadmissible in capital cases. (cnbc.com)
  • Deaths involving fentanyl and other synthetic opioids have surged from around 3,000 in 2013 to more than 30,000 in 2018. (rand.org)
  • The journal Cancer Epidemiology, Biomarkers and Prevention published a CDC study looking at gallbladder cancer incidence and death rates from 2007 through 2011 and trends from 1999 through 2011 in the United States. (cdc.gov)
  • Very few population-based estimates for gallbladder cancer incidence and death rates in the United States have been published. (cdc.gov)
  • CDC researchers used U.S. Cancer Statistics data to figure gallbladder cancer incidence (new cases) and death rates by sex, racial and ethnic group, age group, U.S. Census region, state, county-level poverty, and percent of county population not born in the United States. (cdc.gov)
  • Gallbladder cancer incidence and death rates were highest in the Northeast and Midwest U.S. Census regions. (cdc.gov)
  • A ) Incidence and duration of spontaneous generalized tonic-clonic convulsions 24 hours prior to death. (nih.gov)
  • A close look at cancer incidence and death statistics reveals that certain groups in this country suffer disproportionately from cancer and its associated effects, including premature death. (cancer.gov)
  • For example, African Americans/Blacks, Asian Americans, Hispanic/Latinos, American Indians, Alaska Natives, and underserved Whites are more likely than the general population to have higher incidence and death statistics for certain types of cancer. (cancer.gov)
  • Complex and interrelated factors contribute to the observed disparities in cancer incidence and death among racial, ethnic, and underserved groups. (cancer.gov)
  • How does NCI gather data on cancer incidence and death for various population groups in the United States? (cancer.gov)
  • The incidence and death statistics presented in this fact sheet are from Tables I-23 through I-28 of the SEER Cancer Statistics Review, 1975-2004 ( http://seer.cancer.gov/csr/1975_2004 ). (cancer.gov)
  • Age-adjustment allows cancer incidence and death statistics (expressed below as cancer incidence and death "rates ) for these population groups to be compared. (cancer.gov)
  • What are the overall cancer incidence and death rates for different populations living in the United States? (cancer.gov)
  • In 2009, the number of new death sentences was 112 , the lowest level in 30 years. (aclu.org)
  • Federal prosecutors are twice as likely to reach plea agreements avoiding death sentences with white than with black and Hispanic capital defendants. (thenation.com)
  • Death records in the ISDH Vital Records office begin with 1900. (in.gov)
  • Prior to 1900, records of death are filed only with the local health department in the county where the death actually occurred. (in.gov)
  • For deaths occurring from 1900 to 1917, the city and/or county of death is required in order to locate the record. (in.gov)
  • For U.S. Citizens who died abroad, please visit the U.S. Department of State's Death Abroad webpage. (in.gov)
  • Maryland State's Attorney Marilyn Mosby announces charges against Baltimore police officers in connection with the death of Freddie Gray, in Baltimore, May 1, 2015. (voanews.com)
  • On April 25, 2012, Connecticut Governor Dannel Malloy signed Senate Bill 280 (2012) , ending the state's death penalty. (ncsl.org)
  • We studied the mechanism of premature death in Scn1a heterozygous KO mice and conditional brain- and cardiac-specific KOs. (nih.gov)
  • This review helps tell true SIDS deaths from those due to accidents, abuse, and previously undiagnosed conditions, such as cardiac or metabolic disorders. (kidshealth.org)
  • Larger declines were recorded in relation to deaths from ischaemic heart disease, where death rates fell by 30.3 % for men and 34.3 % for women, while even greater reductions were recorded for deaths from transport accidents where rates fell by 43.3 % for men and 44.3 % for women. (europa.eu)
  • Authorities amended Wood's death certificate on Aug. 1, 2012 to reflect some of the lingering questions about how the actress died in the waters off Catalina Island in November 1981. (yahoo.com)
  • Napalm Death - angielska grupa muzyczna powstała w 1981 roku w Meriden w pobliżu Coventry . (wikipedia.org)
  • Numerous polls repeatedly show that Texans favor the death penalty, even though they fear that innocent people may be put to death. (law.com)
  • However, with the mounting of casualty sensitivity, the state gradually restructured what Levy calls its "death hierarchy" to favor privileged soldiers over soldiers drawn from lower classes and civilians, and later to place enemy civilians at the bottom of the hierarchy by the use of heavy firepower. (jhu.edu)
  • Three days after Safra's death, Daniel Serdet, the attorney general and chief prosecutor of Monaco, announced that a male nurse named Ted Maher, from Stormville, New York, had confessed to setting the blaze that killed his employer in order to win favor with the banker. (vanityfair.com)
  • Thanatology , the description or study of death and dying and the psychological mechanisms of dealing with them. (britannica.com)
  • Thanatology is concerned with the notion of death as popularly perceived and especially with the reactions of the dying, from whom it is felt much can be learned about dealing with death's approach. (britannica.com)
  • Thanatology (from Greek thanatos, "death") as a professional discipline gathered momentum following the publication of several subject-related books including The Meaning of Death (1959), edited by Herman Feifel, and The Psychology of Death (1972) by Robert Kastenbaum and Ruth Aisenberg. (britannica.com)
  • Thanatology also examines attitudes toward death, the meaning and behaviours of bereavement and grief, and the moral and ethical questions of euthanasia , organ transplants, and life support. (britannica.com)
  • Players will be able to tell us any kind of feedback and ideas through the Steam Forums, the official Death Trash Discord, Twitter, and Facebook. (steampowered.com)
  • Since 1973, 138 death-row prisoners have been released because they were innocent. (aclu.org)
  • Japan has often been criticised internationally for its use of the death penalty and the fact that death row prisoners and their families are not told about the execution date in advance. (smh.com.au)
  • To write a letter on behalf of Juan Raul Garza, as well as the other prisoners currently on state and federal death row, visit our Death Row Roll Call . (thenation.com)
  • Also, the papers don't mention it, but this story should give pause to anyone who thinks the death penalty is a deterrent. (slate.com)
  • Parnia thinks of these experiences as actual-death experiences as opposed to near-death experiences. (npr.org)
  • Chatterbox thinks the death of the just-folks obit has the potential to become a significant issue for the baby boom generation. (slate.com)
  • Anyone who thinks the death penalty does not affect Australians need only look next door to Bali, where three Australians are on death row, a rally has heard. (smh.com.au)
  • Japan's justice minister, a foe of capital punishment, has announced a review of the death penalty after witnessing the first executions since her centre-left government took power in 2009. (smh.com.au)
  • This past December, President Clinton put off Garza's execution date because a Justice Department study had raised serious questions about racial, ethnic and geographical disparities in the administration of the federal death penalty. (thenation.com)
  • Ashcroft issued a supplementary report, but it contained no new relevant information and failed to undertake the analysis required to determine whether the federal death-penalty disparities were attributable to bias. (thenation.com)
  • Death then warns the physician that if he was to ever trick Death again, he will take the physician's life. (wikipedia.org)
  • As the physician falls, he hears Death whisper quietly "You once looked for the most righteous one to be the godfather of your child, but at the Bed of Death you betrayed that and instead grasped for the life of another. (wikipedia.org)
  • The question whether there is a life after death does not fall under the jurisdiction of science as science is concerned only with classification and analysis of sense data. (angelfire.com)
  • Moreover, man has been busy with scientific enquiries and research, in the modern sense of the term, only for the last few centuries, while he has been familiar with the concept of life after death since times immemorial. (angelfire.com)
  • All the prophets of God called their people to worship God and to believe in life after death. (angelfire.com)
  • They laid so much emphasis on the belief in life after death that even a slight doubt in it meant denying God and made all other beliefs meaningless. (angelfire.com)
  • The very fact that all the prophets of God have dealt with this metaphysical question of life after death so confidently and so uniformly - the gap between their ages being thousands of years - goes to prove that the source of their knowledge of life after death as proclaimed by them all, was the same, i.e. (angelfire.com)
  • We also know that these prophets of God were greatly opposed by their people, mainly on the issue of life after death as their people thought it impossible. (angelfire.com)
  • Not so, as perceptual experience of life after death is impossible. (angelfire.com)
  • That is why all the prophets of God while calling people to believe in God and life after death, appeal to the aesthetic, moral and rational consciousness of man. (angelfire.com)
  • At another occasion the Quran very clearly says that the disbelievers have no sound basis for their denial of life after death. (angelfire.com)
  • The explanation that the Quran gives about the necessity of life after death is what moral consciousness of man demands. (angelfire.com)
  • Actually if there is no life after death, the very belief in God becomes irrelevant or even if one believes in God, that would be an unjust and indifferent God: having once created man not concerned with his fate. (angelfire.com)
  • If possible have some small life insurance to cover death related expenses. (google.com)
  • Seeing him waver, his wife, who was resolved to be with him in death as in life, took the dagger from his hand, plunged it into her own breast, and with her last strength held it out to him, gasping out, "It is not painful, my Pætus. (upenn.edu)
  • The most comprehensive death penalty study in the country found that the death penalty cost North Carolina $2.16 million more per execution over the costs of sentencing murderers to life imprisonment. (aclu.org)
  • NPR coverage of Erasing Death: The Science That Is Rewriting the Boundaries Between Life and Death by Sam, M.D., Ph.D. Parnia and Josh Young. (npr.org)
  • Circle of death snuffs out the life force of living creatures, killing them instantly. (google.com)
  • Death Sentence is also a manifesto, the first shots, Watson hopes, in a campaign everyone can join to bring the language back to life. (theage.com.au)
  • The sentiments associated with the vanities expressed a range of rather sombre, melancholy notions, including the swift passage of time, the fragility of human life, and the centrality of death in all human affairs. (encyclopedia.com)
  • Whereas the earlier expressions of the macabre often imagined death as a supernatural threat existing outside of human nature, the vanities reconsiders the power of death as an integral condition of life itself. (encyclopedia.com)
  • I suppose you could argue that they are really anti -death cults, what with endless speculation about afterlives and such, but the obsession with the end of life is still there. (umich.edu)
  • A year after Litvinenko's death, Berezovsky said Scotland Yard had warned him about a plot on his life , but British police never confirmed his claim. (yahoo.com)
  • In spite of the recent push toward the death penalty, I do not believe it is mankind's privilege to decide on the life of another human being. (latimes.com)
  • In 1918, the popular religious writer Winifred Kirkland described a change in American life: people were preoccupied with death as never before. (jhu.edu)
  • Studies also show that these effects are reduced for people with low self-esteem if they are provided with "evidence" of life after death (that is, they read near-death experience accounts where people are convinced that there is an afterlife) or if you provide them with evidence that science is enabling people to live longer. (psychologytoday.com)
  • Gallbladder cancer is often found at a late stage with a poor outcome, often death. (cdc.gov)
  • Although cancer deaths have declined for both Whites and African Americans/Blacks living in the United States, African Americans/Blacks continue to suffer the greatest burden for each of the most common types of cancer. (cancer.gov)
  • Furthermore, this increase in risk is comparable to the risk of death from leukemia after long-term exposure to benzene, another solvent, which has the well-known property of causing this type of cancer. (wiktionary.org)
  • In 2015, Hungary reported the highest standardised death rate for lung cancer and for colorectal cancer among the EU Member States. (europa.eu)
  • Between 2005 and 2015, there was an 11.5 % reduction in EU-28 standardised death rates relating to cancer for men and a 6.1 % reduction for women - see Figures 1 and 2. (europa.eu)
  • The standardised death rate for breast cancer fell by 10.1 % for women, which was in excess of the overall change for all cancers. (europa.eu)
  • News of Berezovsky's death sparked speculation that he might have been killed like ex-KGB agent Alexander Litvinenko, who died in 2006 after he was poisoned with polonium-210 while drinking tea at a London meeting. (yahoo.com)
  • Police today said any speculation about Berezovsky's death would be premature. (yahoo.com)
  • Homeless people are at high risk for illness and have higher death rates than the general population. (cmaj.ca)
  • 15 A study of people using homeless shelters in New York found age-adjusted death rates 2 to 3 times higher than those in the city's general population. (cmaj.ca)
  • Defendants who kill white people are far more likely to get the death penalty than those who kill black people. (aclu.org)
  • Sicilian authorities hastily ordered the fleet of "death ships" out of the harbor, but it was too late: Over the next five years, the Black Death would kill more than 20 million people in Europe - almost one-third of the continent's population. (history.com)
  • Because they did not understand the biology of the disease, many people believed that the Black Death was a kind of divine punishment - retribution for sins against God such as greed, blasphemy, heresy, fornication and worldliness. (history.com)
  • The Texas Civil Rights Project reports that 445 people were on Texas' death row in September. (law.com)
  • One classified ad director argued to Chatterbox that the switch from news obits to paid death notices levelled the playing field between people perceived to be newsworthy and people who were not. (slate.com)
  • The latest hangings left 107 people on death row in Japan. (smh.com.au)
  • The amendment is the latest in a number of reforms to the death penalty pushed for by Chinese legal scholars who have complained that many people guilty of trivial crimes or unfairly tried have been executed. (cnbc.com)
  • Chinese legal experts said in practice the death penalty has seldom been used in recent years to punish people who committed these crimes and the draft amendment was largely intended to reflect the current reality. (cnbc.com)
  • In short, this is the notion that people can either draw on their own psychological resources (e. g ., solidified belief systems, relationships) to cope with thinking about death or, if that is not sustainable, cope with thoughts of death by avoiding self-awareness. (psychologytoday.com)
  • The results indicated that people with low self-esteem were less likely to think about themselves, and to write about themselves, after thinking about death versus a variety of other topics (e.g., pain, failure). (psychologytoday.com)
  • Other studies consistent with this line of reasoning show that - after a short delay of minutes - people with low self-esteem will have more negative mood when thinking about death. (psychologytoday.com)
  • As the Gaza offensive of 2009 demonstrates, this new death hierarchy has opened Israel to global criticism. (jhu.edu)
  • Prosecuting a death penalty case is extremely expensive for a state and drains money that could be used for education and social programs. (aclu.org)
  • Just as he is about to light the new candle, Death lifts his scythe and the boy's candle goes out. (wikipedia.org)
  • It has been a poor relation to another, more exciting type of cell death called "apoptosis", or programmed cell death. (newscientist.com)
  • Arnaud Wisman, a lecturer in psychology at the University of Kent, proposed the idea of ' using or losing' the self in relation to thinking about death. (psychologytoday.com)
  • Amid the death penalty debate - much of it centered on Gov. George W. Bush's run for president - there are increasing complaints about the appeals process for those who are sentenced to die in Texas. (law.com)
  • Media Watch reports on media coverage of death threats on climate scientists: One news outlet comes out of it, in our opinion, almost unscathed: Fairfax Media's The Canberra Times. (scienceblogs.com)
  • This doesn't come up at big-city newspapers, because there's no way to run news stories about more than a tiny proportion of the local deaths. (slate.com)
  • But that argument would have been more compelling had the trend toward paid death notices occurred spontaneously, as opposed to being forced on consumers by the shrinking news obit hole. (slate.com)
  • Reports of mass graves, torched casinos, and mutilated bodies have become so commonplace that there are days when the Google Mexico news feed is nothing but a death scroll. (prospect.org)
  • For the latest on Whitney Houston's death, see our music news page. (telegraph.co.uk)
  • We are acutely aware of the level of interest into his death and are focused on conducting a thorough investigation as we would with any unexplained death. (yahoo.com)
  • The group called on the National Transitional Council (NTC), Libya's new leadership, to conduct an 'immediate and transparent' investigation into the deaths in Sirte. (rferl.org)
  • The "my death versus your death" concept emphasizes the irrational belief that while "your death" is a certainty, an exemption may be made in "my case. (britannica.com)
  • The second concept, "partial deaths versus total extinction" stresses the belief that by experiencing the bereavement following the deaths of friends and relatives, a person is brought as close as possible to realizing "partial death. (britannica.com)
  • In studies from a total of 7 cities, the risk of death among homeless women was greater than that among women in the general population by a factor of 4.6 to 31.2 in the younger age group and 1.0 to 2.0 in the older age group. (cmaj.ca)
  • The EU Member States with the highest standardised death rates from ischaemic heart disease were Lithuania, Latvia, Slovakia and Hungary - all close to or above 400 deaths per 100 000 inhabitants in 2015. (europa.eu)
  • in Estonia, Latvia and Denmark, as well as in Serbia, death rates were very close to this level. (europa.eu)