Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Topoisomerase II Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.Ifosfamide: Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)DNA Topoisomerases, Type II: DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.Podophyllotoxin: A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.Vincristine: An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Carboplatin: An organoplatinum compound that possesses antineoplastic activity.Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Bleomycin: A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.Lung Neoplasms: Tumors or cancer of the LUNG.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Cytarabine: A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)Germinoma: A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Teniposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.Nucleic Acid Synthesis Inhibitors: Compounds that inhibit cell production of DNA or RNA.Topoisomerase Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASES.LeukopeniaTransplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Mitoxantrone: An anthracenedione-derived antineoplastic agent.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Neoplasms, Germ Cell and Embryonal: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Infusions, Intravenous: The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.Camptothecin: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)Hematologic Diseases: Disorders of the blood and blood forming tissues.Drug Evaluation: Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.Topoisomerase I Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASE I.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Razoxane: An antimitotic agent with immunosuppressive properties.Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Thrombocytopenia: A subnormal level of BLOOD PLATELETS.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.Drug Resistance, Multiple: Simultaneous resistance to several structurally and functionally distinct drugs.P-Glycoprotein: A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).Organophosphorus Compounds: Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Granulocyte Colony-Stimulating Factor: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.Retroperitoneal NeoplasmsAlopecia: Absence of hair from areas where it is normally present.Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.Bone Marrow DiseasesHematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.HL-60 Cells: A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)Levoleucovorin: A folate analog consisting of the pharmacologically active isomer of LEUCOVORIN.Cell Line, Tumor: A cell line derived from cultured tumor cells.Drug Synergism: The action of a drug in promoting or enhancing the effectiveness of another drug.Small Cell Lung Carcinoma: A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).Mesna: A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.Caspases: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.Drug Screening Assays, Antitumor: Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.DNA Topoisomerases, Type I: DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
Hartmann F. Stähelin
A few years later, in November 1983, etoposide was approved by the U.S. Food and Drug Administration. Etoposide is still ... both compounds were approved by the United States Food and Drug Administration on the same day in November 1983, although they ... etoposide, Vepesid, discovered on October 21, 1966), which remains very clinically successful. Teniposide and etoposide were ... there are an astonishing number of coincidences between etoposide and cyclosporine. The first coincidence was that etoposide ...
... from the first day after the end of chemotherapy to the day of full blood count restoration (ANC > 1000/uL). There is also an ... If the nadir ANC > 500/uL, then the doses of etoposide, doxorubicin, and cyclophosphamide for the next cycle are all increased ... If the nadir ANC < 500/uL for 10 days or more, or if the nadir platelet count at every time falls below 25,000/uL, then the ... but doxorubicin and etoposide should not be reduced below the initial dose (dose in first course). EPOCH chemotherapy: toxicity ...
Mediastinal germ cell tumor
Etoposide is traditionally injected into a pre-prepared isotonic 0.9% sodium chloride intravenous bag (IV) for dilution prior ... Upon administration Emily grabbed her head, cried out in pain, began vomiting, and slipped into a coma - she died three days ... then added the Etoposide resulting in a solution containing 26 times more sodium chloride than was recommended. After ... Emily Jerry was undergoing her last scheduled round of chemotherapy with Etoposide to treat a yolk sac tumor which was ...
Fruit consumed three days before the medicine can still have an effect. The relative risks of different types of citrus fruit ... Etoposide interferes with grapefruit, orange, and apple juices. Fexofenadine (Allegra) Fluvoxamine (Luvox, Faverin, Fevarin and ... On the fourth day 10 mg of oxycodone hydrochloride were administered orally. Analgesic and behavioral effects were reported for ... Bitter oranges (such as the Seville oranges often used in marmalade) can interfere with drugs including etoposide, a ...
cisplatin, etoposide, bleomycin non-seminomatous germ cell tumors PEI cisplatin, etoposide, ifosfamide small-cell lung ... 7 days of Ara-C (cytarabine) plus 3 days of an anthracycline antibiotic, either daunorubicin (DA or DAC variant) or idarubicin ... etoposide, platinum agent testicular cancer, germ cell tumors EPOCH etoposide, prednisone, vincristine (Oncovin), ... daunorubicin x 3 days plus ara-C (cytarabine) x 7 days, a variant of 7+3 regimen Acute myeloid leukemia, excluding acute ...
A. V. Rama Rao
His early researches on plant and insects have been documented in over 70 scientific papers and the latter day work by way of ... Vincristine and Etoposide, apart from AZT. In 1995, when Rao set out to establish his own research centre, Avra Laboratories, ... The Government of India included him in the 1991 Republic Day honours list for the civilian award of the Padma Shri. He was ... he stayed with his grand parents at Guntur during his school days. He graduated in chemistry (BSc) from A. C. College of Andhra ...
The exceptions are poorly differentiated (high-grade or anaplastic) metastatic disease, where cisplatin with etoposide may be ... often by steady infusion over hours or even days. Compared with systemic chemotherapy, a higher proportion of the chemotherapy ... Although marginally effective in well-differentiated PETs, cisplatin with etoposide is active in poorly differentiated ...
Attempts were made to prolong the course (cytarabine for 10 days instead of 7, or daunorubicin/idarubicin for 4-5 days instead ... The addition of etoposide to the standard "7+3" regimen is sometimes of benefit in poor-risk patients (many of which are ... which consists of 7 days of standard-dose cytarabine, and 3 days of an anthracycline antibiotic or an anthracenedione, most ... primary refractory to standard "7+3" induction regimens). It gave rise to the so-called ADE (or DAE = DA + etoposide) induction ...
Chemotherapy-induced nausea and vomiting
... which can occur during the 2-5 days after treatment. Since some patients have trouble swallowing pills, these drugs are often ... Carboplatin Methotrexate Doxorubicin/Adriamycin Docetaxel Paclitaxel Etoposide Ifosfamide Cyclophosphamide (≤1500 mg/m2) CHOP/ ... and dietary modifications such as eating several small meals throughout the day, eating high-protein, high-calorie food, ... occurring between 24 hours and 5 days after treatment Breakthrough: occurring despite prophylactic treatment Anticipatory: ...
... -related toxicities can occur acutely after administration, within hours or days, or chronically, from weeks to ... Podophyllotoxin is used to produce two other drugs with different mechanisms of action: etoposide and teniposide. Topoisomerase ... ifosfamide and etoposide. Permanent thinning or hair loss can result from some standard chemotherapy regimens. Chemotherapy ... These agents include etoposide, doxorubicin, mitoxantrone and teniposide. The second group, catalytic inhibitors, are drugs ...
... die per day. That is, about 5 out of every 1,000 cells (0.5%) die each day due to apoptosis. ... An etoposide-treated DU145 prostate cancer cell exploding into a cascade of apoptotic bodies. The sub images were extracted ... The average adult human loses between 50 and 70 billion cells each day due to apoptosis.[a] For an average human child ... In addition, after embryonic day 12.5, the brain of the embryos showed several structural changes. APAF-1 cells are protected ...
Hyperpolarized carbon-13 MRI
WHO Model List of Essential Medicines for Children
Acute lymphoblastic leukemia
... although literature supports that higher-grade astroblastoma affect a patient with day-to-day activities, forcing individuals ... A standard chemotherapy protocol starts with two rounds of nimustine hydrochoride (ACNU), etoposide, vincristine, and ... and etoposide will "shock" the patient's system to the point where recurrence halts. Unfortunately, chemotherapy may not always ... powerful pressure in a matter of days. The time-frame for this pressure varies from patient to patient and fluctuate based on ...
WHO Model List of Essential Medicines
In the UK (in 2009) The cost of six cycles (18 weeks) of docetaxel at a dose of 75 mg/m2 IV every 21 days is £5,262 (based on ... Etoposide has also been shown to decrease docetaxel clearance, though patient numbers for this observation have been low. ... Cisplatin, dexamethasone, doxorubicin, etoposide, and vinblastine are all potentially co-administered with docetaxel and did ... Of the radioactively labelled docetaxel administered, 80% was eliminated to the faeces with 5% in the urine over seven days, an ...
Later that day, BMS announced that Dolan would indeed step down. ... Etopophos (etoposide). *Ixempra (ixabepilone). *Lysodren (mitotane). *Megace (megestrol acetate). *Opdivo (nivolumab) is a ... premium to the previous days closing price. Investor opposition to this acquisition, leading into an April 12 shareholder ... months for its Inhibitex's shareholders acceptance of 126 percent premium price of its price over the previous 20 trading days ...
Chemotherapy-induced nausea and vomiting
... which can occur during the 2-5 days after treatment. Since some patients have trouble swallowing pills, these drugs are often ... Etoposide. *Ifosfamide. *Methotrexate. *Paclitaxel. Besides the type of treatment, personal factors may put a patient at ... and dietary modifications such as eating several small meals throughout the day, eating high-protein, high-calorie food, ...
Days 1-5 R-Maxi-CHOP is used in mantle cell lymphoma and is given in 21-day intervals, alternating with R-HDAC (rituximab + ... Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis ( ... Day 1 (P)rednisone or (P)rednisolone. 40 mg/m². 100 mg. PO qd. ... Day 1 (H)ydroxydaunorubicin. 50 mg/m². 75 mg/m². IV bolus. Day ... Day 1 (C)yclophosphamide. 750 mg/m². 1200 mg/m². IV infusion. ... Day 1 (O)ncovin. 1,4 mg/m² (max 2 mg). 2 mg. 2 mg. 2 mg. 2 mg. ...
Lance Armstrong Bahasa Melayu, ensiklopedia bebas
I-131 has a half-life of 8 days and at higher doses is an effective therapy as targeted radiation against relapsed and ... etoposide), anthracycline antibiotics (doxorubicin) and vinca alkaloids (vincristine). Some newer regimens include ... "Day care, childhood infections, and risk of neuroblastoma". American Journal of Epidemiology. 159 (9): 843-51. doi:10.1093/aje ...
Podophyllotoxin is used to produce two other drugs with different mechanisms of action: etoposide and teniposide. ... Chemotherapy-related toxicities can occur acutely after administration, within hours or days, or chronically, from weeks to ... ifosfamide and etoposide. Permanent thinning or hair loss can result from some standard chemotherapy regimens. ... These agents include etoposide, doxorubicin, mitoxantrone and teniposide. The second group, catalytic inhibitors, are drugs ...
WHO Model List of Essential Medicines
Foscan can render patients photosensitive for up to 20 days after initial illumination. ... Purlytin has been reported to localise in skin and produce a photoreaction 7-14 days post-administration. ... accumulates selectively in cancer cells and reaches a maximum concentration after about one day. The compound provides real ...
Pratélan Usada Pokok Modhèl WHO
Kanser, ang malayang ensiklopedya
Etoposide, platinum agent (cisplatin (Platinol)) Testicular cancer, germ cell tumors EPOCH Etoposide, prednisone, Oncovin, ... Ang World Cancer Day ay ipinagdiriwang taon-taon tuwing Pebrero 4.. Mga sanggunian[baguhin , baguhin ang batayan]. *↑ "How many ... Bleomycin, etoposide, platinum agent (cisplatin (Platinol)) Testicular cancer, germ cell tumors CA Cyclophosphamide, Adriamycin ... ifosfamide, carboplatin, etoposide (VP-16) Aggressive lymphomas, progressive neuroblastoma ICE-R ICE + rituximab High-risk ...
Ostra białaczka szpikowa, wolna encyklopedia
Later that day, BMS announced that Dolan would indeed step down. The Deferred Prosecution Agreement expired in June 2007 and ... etoposide) Ixempra (ixabepilone) Lysodren (mitotane) Megace (megestrol acetate) Opdivo (nivolumab) is a programmed death ... months for its Inhibitex's shareholders acceptance of 126 percent premium price of its price over the previous 20 trading days ...
Intensity-Modulated Radiation Therapy, Etoposide, and Cyclophosphamide Followed By Donor Stem Cell Transplant in Treating...
Patients also receive etoposide IV on day -6 or -5 and cyclophosphamide IV on day -4 or -3. TRANSPLANTATION: Patients undergo ... Patients also receive etoposide intravenously (IV) on day -6 or -5 and cyclophosphamide IV on day -4 or -3. ... TRANSPLANTATION: Patients undergo allogeneic peripheral blood stem cell or bone marrow transplantation on day -1 or day 0. ... PREPARATIVE REGIMEN: Patients undergo IMRT using helical tomotherapy once or twice daily on days -10 to -6 or -10 to -7. ...
Discovery Stage IND EXEMPT Clinical Study - Etoposide and Single Nucleotide Polymorphisms - Tabular View - ClinicalTrials.gov
Time Frame: Duration at least 180 days ]. *Recruit 300 double blind random group separated SCLC patients currently used the ... Drug: ETOPOSIDE - Study ETOPOSIDE INJECTION plus CARBOPLATIN INJECTION. Other Name: ETOPOSIDE generic plus CARBOPLATIN generic ... Randomised phase III trial of carboplatin plus etoposide vs split doses of cisplatin plus etoposide in elderly or poor-risk ... Discovery Stage IND EXEMPT Clinical Study - Etoposide and Single Nucleotide Polymorphisms (Drugs-SNPs). The safety and ...
Etoposide Phosphate - Drug Information - Chemocare
To help treat/prevent mouth sores, use a soft toothbrush, and rinse three times a day with 1/2 to 1 teaspoon of baking soda and ... Topoisomerase II inhibitors: Amsacrine, etoposide, etoposide phosphate, teniposide. Note: We strongly encourage you to talk ... The amount of etoposide that you will receive and the method it is given depends on many factors, including your height and ... Pregnancy category D (etoposide may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the ...
Valsalva-Like Retinopathy Secondary to Pancytopenia following Induction of Etoposide and Ifosfamide
The hemorrhage resolved spontaneously after 10 days. This case illustrates how bone marrow suppression by chemotherapeutic ... We describe a case of a patient on etoposide and ifosfamide who presented with unilateral vision loss, anemia, and ... Etoposide and ifosfamide are chemotherapeutic agents used frequently in the treatment of sarcomas and hematologic malignancies ... The patients hemoglobin and platelets are graphed in the days after initiating etoposide and ifosfamide. The minimum value of ...
A Multicenter Randomized Phase III Study Comparing Paclitaxel-Cisplatin-Etoposide (TEP) Versus Cisplatin-Etoposide (EP) as...
Cycles were repeated every 28 days.. *Responding limited stage (LS) pts proceed to thoracic XRT after completion of ... A Multicenter Randomized Phase III Study Comparing Paclitaxel-Cisplatin-Etoposide (TEP) Versus Cisplatin-Etoposide (EP) as ... A Multicenter Randomized Phase III Study Comparing Paclitaxel-Cisplatin-Etoposide (TEP) Versus Cisplatin-Etoposide (EP) as ... Etoposide Etoposide Oral Formula Eulexin® Everolimus Evista® Exemestane ...
Cisplatin Carboplatin and Etoposide or Temozolomide and Capecitabine in Treating Patients With Neuroendocrine Carcinoma of the...
Cisplatin Carboplatin and Etoposide or Temozolomide and Capecitabine in Treating Patients With Neuroendocrine Carcinoma of the ... on days 1-3 or carboplatin IV on day 1. Patients also receive etoposide IV on days 1-3. Courses repeat every 21 days in the ... ARM A: Patients receive capecitabine orally (PO) twice daily (BID) on days 1-14 and temozolomide PO once daily (QD) on days 10- ... Cisplatin Carboplatin and Etoposide or Temozolomide and Capecitabine in Treating Patients With Neuroendocrine Carcinoma of the ...
Etoposide and cisplatin - Macmillan Cancer Support
Etoposide and cisplatin chemotherapy, known as EP (or sometimes PE), is used to treat many cancers. Find out more about the ... Each cycle of EP takes 21 days (three weeks).. *Day one - you have etoposide as a drip (infusion) over an hour and cisplatin as ... Days two and three - you have a drip of etoposide, or etoposide capsules to take. ... If your skin feels dry, try using an unperfumed moisturising cream every day. Etoposide can cause a rash, which may be itchy. ...
Mitoxantrone, Etoposide, and Cytarabine (MEC) Plus Lenalidomide for Relapsed or Refractory Acute Myeloid Leukemia - Full Text...
Days to ANC recovery [ Time Frame: up to 45 days ]. Time from the first day of chemotherapy to the first day where the ... Days of platelet recovery [ Time Frame: up to 45 days ]. Time from the first day of chemotherapy to the first day where the ... Mitoxantrone, Etoposide, and Cytarabine are administered intravenously on a daily basis for days 4 through 8 of the treatment. ... Etoposide. Etoposide phosphate. Mitoxantrone. Immunologic Factors. Physiological Effects of Drugs. Growth Substances. Growth ...
Etoposide and cisplatin chemotherapy (EP) - Information and support - Macmillan Cancer Support
Each cycle of EP takes 21 days (three weeks).. *Day one - you have etoposide as a drip (infusion) over an hour and cisplatin as ... Days two and three - you have a drip of etoposide, or etoposide capsules to take. ... If your skin feels dry, try using an unperfumed moisturising cream every day. Etoposide can cause a rash, which may be itchy. ... If you forget to take the capsules, you should take the missed dose as soon as possible within the same day. If a full day has ...
Carboplatin, Etoposide, Cyclophosphamide, and Autologous Bone Marrow Transplantation in Patients With Relapsed or Refractory...
OUTLINE: Patients receive carboplatin and etoposide for 5 days and cyclophosphamide for 2. days prior to ABMT.. At day 60 ... etoposide, and cyclophosphamide chemotherapy and ABMT in patients with relapsed and. refractory germ cell cancer or other ... No prior high-dose carboplatin, etoposide, or cyclophosphamide. Endocrine therapy:. - Not specified. Radiotherapy:. - Not ... High Dose Carboplatin, Etoposide, Cyclophosphamide and Autologous Bone Marrow Transplantation for Relapsed and Refractory Germ ...
Transient excess of MYC activity can elicit genomic instability and tumorigenesis | PNAS
Rat1A(MYCER) untreated (□), treated with E2 (10 μM) for 2 days (■), treated with E2 for 2 days followed by 14 days (●) or 30 ... Etoposide and UV Sensitivity.. Rat1A(MYCER) or NHF(MYCER) were irradiated with UV (1-20 J/m2) or exposed to etoposide (0.01-10 ... NHF(BABE) or NHF(MYCER) cells were treated with PALA (50 μM) for two days and then analyzed for DNA content by fluorescence- ... The increase persisted for ,30 days after the return of MYC activity to normal levels. The brief surfeit of MYC activity was ...
Epstein-Barr virus-mediated protection against etoposide-induced apoptosis in BJA-B B cell lymphoma cells: role of Bcl-2 and...
"Epstein-Barr virus-mediated protection against etoposide-induced apoptosis in BJA-B B cell lymphoma cells: role of Bcl-2 and ... Sign up for your 14-Day Free Trial Now!. Read and print from thousands of top scholarly journals. ... Bax showed no etoposide-induced alterations in expression. Pro-caspase-9 and -3 were seen in both EBV-positive and -negative ... Etoposide induced cleavage of caspase-9 in both cell lines, with the EBV-positive cells having proportionally less cleavage ...
Cisplatin/etoposide, Reactions Weekly | 10.1007/s40278-017-39019-x | DeepDyve
"Cisplatin/etoposide, Reactions Weekly" on DeepDyve, the largest online rental service for scholarly research with thousands of ... Sign up for your 14-Day Free Trial Now!. Read and print from thousands of top scholarly journals. ... Cisplatin/etoposide. Cisplatin/etoposide 2017-12-02 00:00:00 Reactions 1680, p88 - 2 Dec 2017 Haematological disorders and hair ... Cisplatin/etoposide. Add Journal to My Library Reactions Weekly , Volume 1680 (1) - Dec 2, 2017 ...
Abstract B81: Phase I/II trial of vorinostat in combination with etoposide in pediatric patients with relapsed/refractory solid...
Etoposide was administered at a fixed dose of 100 mg/m2/day on days 3-5 of the treatment cycle. Etoposide was administered 4 ... Vorinostat was administered once daily for days 1-4 of the treatment cycle in escalating doses (125 mg/m2, 160 mg/m2, 210 mg/m2 ... The recommended phase II dose was established at vorinostat 270 mg/m2 and etoposide 100 mg/m2 and will be evaluated in an ... One patient experienced a DLT (Gr 4 platelet count decreased) at the 1stdose level (125 mg/m2 vorinostat,100 mg/m2 etoposide). ...
A Study Of Cisplatin (Or Carboplatin) And Etoposide With Or Without Figitumumab (CP-751,871) In Patients With Extensive-Stage...
Day 1 and Day 2 (within 3 hours prior to Day 1 etoposide infusion; 1, 1.5, 2, 3, 6, and 24 hours post Day 1 etoposide infusion ... Day 1 and Day 2 (within 3 hours prior to Day 1 etoposide infusion; 1, 1.5, 2, 3, 6, and 24 hours post Day 1 etoposide infusion ... or Day 1 of the initial cycle starting single agent figitumumab); Day 1 of Cycles 2 and 4; Day 28 and Day 90 post last ... Drug: Etoposide Etoposide (100 mg/m2 IV on Days 1, 2 and 3) ... Day 2; Day 1 of Cycles 2, 4, 5, 6, 10 and 15; Day 28 and Day 90 ...
Etoposide: MedlinePlus Drug Information
Etoposide: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Etoposide comes as a capsule to take by mouth. It is usually taken once a day for 4 or 5 days in a row. This cycle may be ... Take etoposide at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your ... Before taking etoposide,. *tell your doctor and pharmacist if you are allergic to etoposide, any other medications, or any of ...
Methotrexate, Cyclophosphamide, and Etoposide Phosphate Given With Osmotic Blood-Brain Barrier Disruption Plus Dexamethasone...
... etoposide phosphate, dexamethasone, and cytarabine, work in different way ... over 10 minutes, and etoposide phosphate IV over 10 minutes on days 1 and 2 in conjunction. with osmotic blood-brain barrier ... 6 hours on days 2-15 (followed by a taper) and intraventricular or intrathecal cytarabine on. day 14. Beginning 48 hours after ... past 30 days. - No known allergy to study agents. - HIV negative. PRIOR CONCURRENT THERAPY:. Biologic therapy. - Not specified ...
Mutual Inhibition between Quinine and Etoposide by Human Liver Microsomes | Drug Metabolism & Disposition
The effect of etoposide on the 3-hydroxylation of quinine is shown in fig. 1. Etoposide inhibited the microsomal metabolism of ... The effect of quinine on the 3′-demethylation of etoposide is shown in fig. 2. The results showed that the etoposide 3′- ... The mean maximum inhibition by etoposide (100 μM) of quinine 3-hydroxylation was about 60%. Similarly, etoposide 3′- ... and etoposide 3′-demethylation by about 75% and 65%, respectively. We conclude that quinine and etoposide mutually inhibit the ...
1462-BEACOPP standard dose (bleomycin etoposide DOXOrubicin CYCLOPHOSPHamide SUP | eviQ
ONCE a day on days 1 to 14. Take in the morning with food.. ... ONCE a day on days 1 to 7. Etoposide. 100 mg/m2 (IV infusion) ... Etoposide conversion factor Note: Etopophos (etoposide phosphate) 113.6 mg is equivalent to etoposide 100 mg.. Doses in this ... Etopophos (etoposide phosphate) 113.6 mg is equivalent to etoposide 100 mg. Doses in this protocol are expressed as etoposide. ... Etopophos (etoposide phosphate) 113.6 mg is equivalent to etoposide 100 mg. Doses in this protocol are expressed as etoposide. ...
1178-Autologous conditioning protocol germ cell tumour TICE (cARBOplatin and Etoposide) (part 2) | eviQ
Note: Day -1 is a rest day; stem cells are given back on day 0. ... Note: 1 mg of etoposide = 1.136 mg Etopophos (etoposide ... Etoposide conversion factor Doses in this protocol are expressed as etoposide. Note: Etopophos (etoposide phosphate) 113.6 mg ... etoposide phosphate) is the preferred formulation.. Note: 1 mg of etoposide = 1.136 mg Etopophos (etoposide phosphate) ... Day 1. Pegfilgrastim. 6 mg (Subcut) inject subcutaneously on day +1 (alternatively can be substituted for filgrastim or ...
A phase II trial of pre-irradiation chemotherapy with BCNU, cisplatin and oral etoposide combined with radiation therapy in the...
... cisplatin and oral etoposide combined with radiation therapy in the treatment of glioblastoma (GBM) No significant improvement ... Treatment: BCNU 40 mg/m2/d IV over one hour on days 1-3, VP-16 50 mg/d PO days 1-21 and 29-49, and cisplatin 20 mg/m2/d IV days ... We therefore conducted a phase II trial of pre-irradiation BCNU, cisplatin and etoposide in patients with newly diagnosed GBM. ... Results: The primary efficacy endpoint is percent survival at 365 days. Currently, with 54 deaths and follow-up on those still ...
Etoposide (Toposar®, VePesid®, Etopophos®,VP-16) | OncoLink
Etoposide is an antineoplastic chemotherapy medication used in combination with other medications to treat testicular and small ... Plan times to rest during the day and conserve energy for more important activities. Exercise can help combat fatigue; a simple ... How to Take Etoposide. Etoposide is given by intravenous (IV, into a vein) infusion. It can also be given by mouth in the form ... About: Etoposide (Toposar®, VePesid®, Etopophos®,VP-16) Etoposide works by blocking the action of an enzyme in cells called ...
Chemotherapy for Gestational Trophoblastic Disease
Etoposide: It is given IV, every day for 3 to 5 days, followed by several days of treatment. This is used much less often by ... Actinomycin-D is given in a vein (intravenously, or IV) every day for 5 days, followed by several days without treatment. It is ... and leucovorin is given on days 2, 4, 6, and 8. Each cycle has 8 days of drug treatment, followed usually by a 7-day rest ... Methotrexate can be injected into a vein or a muscle every day for 5 days. This can be repeated again after a rest period based ...
Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers
After 3 days, cells were fixed and permeabilized using conventional methods. Then, the cells were incubated with anti-Sirt1 (sc ... After treatment with etoposide, MTT (25 μl of 5 mg/ml MTT in sterile PBS) was added to 100 μl of a cell suspension and ... Etoposide (Sigma) was used at 20 μM for the indicated times.. Immunoblot analysis. Cells were lysed in lysis buffer, and cell ... mRNA expression of Bax, Bcl-Xl, p53 and p21 in response to etoposide treatment for 48 h was assessed by qRT-PCR in TPC1 (A), ...
Pediatric Thymoma: Background, Pathophysiology, Epidemiology
Clinical trial: Sorafenib Combined With Cisplatin and Etoposide or Carboplatin and Pemetrexed in Treating Patients With...
Sorafenib Combined With Cisplatin and Etoposide or Carboplatin and Pemetrexed in Treating Patients With Metastatic Solid Tumors ... day 1 of all subsequent courses; etoposide IV over 30 minutes on days 1-3; and oral sorafenib tosylate once or twice daily on ... No non-steroidal anti-inflammatory drugs (NSAIDs) for 2 days before (5 days for long-acting NSAIDs), during, and for 2 days ... over 10 minutes on day 1. Patients also receive sorafenib tosylate as in group 1. Treatment repeats every 21 days in the ...
CiNii 論文 - The value of oral cytarabine ocfosfate and etoposide in the treatment of...
Pharmakokinetics of low dose 1-b-D-arabinofuranosylcytosine given by continuous intravenous infusion over twenty-one days. ... The value of oral cytarabine ocfosfate and etoposide in the treatment of refractory and elderly AML patients * * HORIKOSHI ... A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes ... Cytosine arabinoside, idarubicin and divided dose etoposide for the treatment of acute myeloid leukemia in elderly patients ...
Etoposide Phosphate (Etopophos) | Davis's Drug Guide
Find information on Etoposide Phosphate (Etopophos) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... You can cancel anytime within the 30-day trial, or continue using The Washington Manual to begin a 1-year subscription ($39.95) ... etoposide phosphate is a topic covered in the Daviss Drug Guide. To view the entire topic, please sign in or purchase a ... "Etoposide Phosphate." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Washington Manual, www.unboundmedicine.com/ ...
Reduction of atherosclerotic lesions in rabbits treated with etoposide | IJN
Starting from day 30, nine animals were treated with four weekly intravenous injections of etoposide oleate (6 mg/kg) ... In previous studies, treatment of refractory cancer patients with etoposide associated with LDE had been shown devoid of ... In this study, the ability of etoposide to reduce lesions and inflammatory factors in atherosclerotic rabbits was investigated. ... The ability of LDE-etoposide to strongly reduce the lesion area and the inflammatory process warrants the great therapeutic ...
JCI - cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity
5 for etoposide group). After 8 days, mice were rechallenged with live CT26 cells. Shown are the percentages of tumor-free mice ... Eight days later, 5 × 105 live CT26 cells were inoculated into the right flank, and the tumor growth was monitored. For ... The growth of the tumors was observed for 6 to 7 days, after which teniposide or vehicle was administered by i.p. injection (10 ... O) Mice were injected with CD8 or CD4 depletion antibody on days 3, 6, and 9 after CT26 tumor inoculation, followed by ...
CyclophosphamideCarboplatin and etoposideSide effects of etoposidePhosphateIfosfamideVePesidBleomycinVincristineDoxorubicinCytarabineApoptosisPaclitaxelRegimenPatients received etoposideIntravenouslyChemoDosesCyclesInfusionEffect of etoposideSuggest that etoposideRefractoryRadiotherapyReceive etoposideDrugsSCLCTreatmentSolid tumorsTopotecanInhibitorToposarAntineoplastic agentAntitumor activityMedicationsMethotrexateTumorsChemotherapeuticOralPrednisoneSemisynthetic derivativePhaseInhibitCytotoxicCCNUINJECTIONEfficacyRadiation therapyInductionOrally
- Investigate the response rate, duration of response, survival, time to marrow reconstitution, and toxicity of two successive cycles of high dose carboplatin, etoposide, and cyclophosphamide chemotherapy and ABMT in patients with relapsed and refractory germ cell cancer or other chemotherapy-sensitive solid tumors. (knowcancer.com)
- OUTLINE: Patients receive carboplatin and etoposide for 5 days and cyclophosphamide for 2 days prior to ABMT. (knowcancer.com)
- Determine the toxicity and efficacy of methotrexate, cyclophosphamide, and etoposide phosphate administered in conjunction with osmotic blood-brain barrier disruption and dexamethasone and cytarabine in patients with primary CNS lymphoma. (knowcancer.com)
- Patients receive methotrexate (MTX) intra-arterially over 10 minutes, cyclophosphamide IV over 10 minutes, and etoposide phosphate IV over 10 minutes on days 1 and 2 in conjunction with osmotic blood-brain barrier disruption. (knowcancer.com)
- Carboplatin, etoposide phosphate, cyclophosphamide. (medalerts.org)
- 21 years of age (at diagnosis) support the use of etoposide (in combination with bleomycin, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone [BEACOPP regimen]) for the treatment of advanced stage Hodgkin lymphoma [Kelly . (drugs.com)
- The present study aimed to determine a maximum practicable dose of three drugs, ie, etoposide, adriamycin, and cyclophosphamide, for which acute toxicities were acceptable and to assess the feasibility of the escalated scheme. (eurekamag.com)
- The intended doses of adriamycin, etoposide, and cyclophosphamide in the BEACOPP schedule could be substantially escalated: adriamycin from 25 to 35, cyclophosphamide from 650 to 1,200, and etoposide from 100 to 200 mg/m2. (eurekamag.com)
- These results show that a moderate dose escalation of adriamycin, cyclophosphamide, and etoposide of the baseline BEACOPP regimen is feasible. (eurekamag.com)
- 6. Coleman M, Ruan J, Furman RR, Niesvizky R, Martin P, Leonard JP: Oral combination chemotherapy for refractory / relapsed lymphoma with the PEP-C (C3) regimen (daily prednisone, etoposide, procarbazine, cyclophosphamide): low dose continuous metronomic multidrug therapy. (aahpm.org)
- The regimens consisted of two or three agents from among carboplatin, doxorubicin, cyclophosphamide, and etoposide. (medpagetoday.com)
- Dose escalation above the starting doses in case of good patient's chemotherapy tolerability applies simultaneously to etoposide, doxorubicin and cyclophosphamide. (wikipedia.org)
- 500/uL, then the doses of etoposide, doxorubicin, and cyclophosphamide for the next cycle are all increased by 20% over the doses used in the previous cycle. (wikipedia.org)
- A two-year-old boy with an ependymoma was admitted for administration of chemotherapy (cyclophosphamide, methotrexate, etoposide and cisplatin). (cmaj.ca)
- All received a uniform preparative regimen of cyclophosphamide, BCNU and etoposide (CBV). (nature.com)
- In 1997 we originally reported on 110 adult patients receiving a uniform chemotherapy only preparative regimen (cyclophosphamide, BCNU and etoposide (CBV)) receiving ABMT from 1988 to 1993 and demonstrated that if in complete remission 2 years post transplant, patients with high grade NHL were cured. (nature.com)
Carboplatin and etoposide8
- This randomized phase II trial studies how well temozolomide and capecitabine work compared to standard treatment with cisplatin or carboplatin and etoposide in treating patients with neuroendocrine carcinoma of the gastrointestinal tract or pancreas that has spread to other parts of the body (metastatic) or cannot be removed by surgery. (centerwatch.com)
- Drugs used in chemotherapy, such as temozolomide, capecitabine, cisplatin, carboplatin and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (centerwatch.com)
- It is not yet known whether temozolomide and capecitabine may work better than cisplatin or carboplatin and etoposide in treating patients with this type of neuroendocrine carcinoma, called non-small cell neuroendocrine carcinoma. (centerwatch.com)
- I. To assess the progression free survival (PFS) of platinum (cisplatin or carboplatin) and etoposide versus the PFS of temozolomide and capecitabine in patients with advanced G3 non-small cell gastroenteropancreatic neuroendocrine carcinomas. (centerwatch.com)
- Patients received ICE (ifosfamide, carboplatin and etoposide) on days 1 to 3. (nih.gov)
- OTCQX: RHHBY) today announced that the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for Tecentriq ® (atezolizumab) in combination with chemotherapy (carboplatin and etoposide) for the initial (first-line) treatment of adults with extensive-stage small cell lung cancer (ES-SCLC). (roche.com)
- IMpower133 is a Phase III, multicentre, double-blinded, randomised placebo-controlled study evaluating the efficacy and safety of Tecentriq in combination with chemotherapy (carboplatin and etoposide) vs. chemotherapy (carboplatin and etoposide) alone in chemotherapy-naïve adults with ES-SCLC. (roche.com)
- My mother has also had nausea with the second cycle (carboplatin and etoposide) which she didn't have with the first. (cancer.org)
Side effects of etoposide3
- The side effects of etoposide and their severity depend on how much of the drug is given. (chemocare.com)
- There are a number of things you can do to manage the side effects of etoposide. (oncolink.org)
- Some of the common side effects of etoposide include nausea, vomiting, hairloss, and low counts of certain blood cells. (rxwiki.com)
- Etopophos (etoposide phosphate) 113.6 mg is equivalent to etoposide 100 mg. (eviq.org.au)
- Doses in this protocol are expressed as etoposide, however Etopophos (etoposide phosphate) is the preferred formulation. (eviq.org.au)
- in 50 mL over 30 to 60 minutes (etoposide phosphate is the preferred formulation and all administration details in this protocol refer to etopophos). (eviq.org.au)
- etoposide phosphate is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
- Washington Manual , www.unboundmedicine.com/washingtonmanual/view/Davis-Drug-Guide/109245/all/etoposide_phosphate. (unboundmedicine.com)
- This randomized phase II trial studies paclitaxel and carboplatin to see how well they work compared with bleomycin sulfate, etoposide phosphate, and cisplatin in treating patients with sex cord-ovarian stromal tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced) or has returned (recurrent). (osu.edu)
- ARM II: Patients receive bleomycin sulfate IV on day 1 and etoposide phosphate* IV over 1 hour and cisplatin IV over 30 minutes on days 1-5. (osu.edu)
- Etoposide and ifosfamide are chemotherapeutic agents used frequently in the treatment of sarcomas and hematologic malignancies. (hindawi.com)
- We describe a case of a patient on etoposide and ifosfamide who presented with unilateral vision loss, anemia, and thrombocytopenia. (hindawi.com)
- This study describes the prevalence of chemotherapy-induced nausea and vomiting (CINV) in pediatric patients receiving etoposide plus ifosfamide over 5 days, a common pediatric regimen. (springer.com)
- English-speaking, non-chemotherapy-naïve patients aged 4 to 18 years about to receive etoposide 100 mg/m 2 /day plus ifosfamide 1800 mg/m 2 /day over 5 days participated. (springer.com)
- Our findings support the classification of etoposide 100 mg/m 2 /day plus ifosfamide 1800 mg/m 2 /day IV over 5 days as highly emetogenic. (springer.com)
- and ifosfamide 1800 mg/m(2), intravenously on days 1-4) plus simultaneous 1-h regional deep hyperthermia (41-43°C) on days 1 and 4. (nih.gov)
- So we started TI that day - it went well but what i wasnt aware of the local doctor reduced the amount of taxol by 30% and ifosfamide by 50% as i was just coming off BEP. (tc-cancer.com)
- Hepatotoxicity with etoposide-ifosfamide combination therapy]. (uptodate.com)
- Combination chemotherapy with etoposide and ifosfamide in 2 patients with advanced bronchial carcinomas caused hepatotoxic side effects. (uptodate.com)
- four of them, including etoposide (Vepesid), were later marketed. (wikipedia.org)
- Further chemical modifications led to the well-known thenylidene derivative VM-26 (teniposide, Vumon, discovered in October 1965, commercialized by Sandoz in 1976) and to the ethylidene derivative VP-16-213 (etoposide, Vepesid, discovered on October 21, 1966), which remains very clinically successful. (wikipedia.org)
- VePesid (etoposide) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. (drugs.com)
- VePesid ® (etoposide) (also commonly known as VP-16) is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. (drugs.com)
- Determined to improve patients' quality of life with a convenient, well-tolerated, and efficacious treatment, the investigators designed an oral chemotherapy regimen consisting of 28-day cycles of etoposide (VePesid) and uracil/tegafur (UFT) plus leucovorin (UFT/LV, also known as Orzel, investigational). (cancernetwork.com)
- I. To assess the activity of paclitaxel and carboplatin with respect to progression free survival (using bleomycin, etoposide, and cisplatin [BEP] as a reference) for newly diagnosed advanced or recurrent chemonaive ovarian sex cord-stromal tumors. (osu.edu)
- I. To estimate the toxicity of paclitaxel and carboplatin, and bleomycin, etoposide, and cisplatin in this patient population. (osu.edu)
- Effect of Zinc on Spermatogenesis and Sperm Chromatin Condensation in Bleomycin, Etoposide, Cisplatin Treated Rats. (americanelements.com)
- Co-administration of bleomycin, etoposide and cisplatin (BEP) has increased survival rate of patients with testicular cancer. (americanelements.com)
- Data from a prospective clinical study support the use of etoposide (in combination with mechlorethamine, vinblastine, vincristine, bleomycin, doxorubicin, and prednisone [Stanford V regimen]) for the treatment of locally extensive and advanced Hodgkin lymphoma [Horning . (drugs.com)
- ABVD chemotherapy: Patients receive doxorubicin hydrochloride IV over 3-5 minutes, bleomycin sulfate IV over 3-5 minutes, vinblastine IV over 3-5 minutes, and dacarbazine IV over 30 minutes on days 1 and 15. (bioportfolio.com)
- and bleomycin sulfate IV and vincristine IV on day 8. (bioportfolio.com)
- The combination of MEC (mitoxantrone, etoposide, and cytarabine) is a standard treatment option, commonly used for relapsed or refractory acute myeloid leukemia. (clinicaltrials.gov)
- Mitoxantrone, Etoposide, and Cytarabine are administered intravenously on a daily basis for days 4 through 8 of the treatment. (clinicaltrials.gov)
- 6 hours on days 2-15 (followed by a taper) and intraventricular or intrathecal cytarabine on day 14. (knowcancer.com)
- 1. Cytarabine is given as an intravenous injection via a drip into your Hickman line at 12 hourly intervals for 8 or 10 days. (newcastle-hospitals.org.uk)
- Epstein-Barr virus-mediated protection against etoposide-induced apoptosis in BJA-B B cell. (deepdyve.com)
- EBV-positive and EBV-negative BJA-B B cell lymphoma cell lines were used to compare the expression of selected apoptosis-regulating Bcl-2 and caspase proteins in EBV-related apoptosis resistance, after 8 hr or 18-24 hr etoposide treatment (80 µM). (deepdyve.com)
- Etoposide induced cleavage of caspase-9 in both cell lines, with the EBV-positive cells having proportionally less cleavage product, in agreement with their lower levels of apoptosis. (deepdyve.com)
- The results indicate that apoptosis resistance in EBV-infected B cell lymphomas is promoted by an inactive caspase-3 pathway and elevated expression of Bcl-2 that is not altered by etoposide drug treatment. (deepdyve.com)
- As revealed by increased caspase-3-like protease activity, nuclear condensation and fragmentation, and trypan blue uptake, treatment with 4003 induced apoptosis and sensitized tumor cells to the chemotherapeutic agent etoposide. (aacrjournals.org)
- One day post-transfection, cells were treated with etoposide to induce apoptosis. (thermofisher.com)
- In SMS-KNCR neuroblastoma cells, 13- cis -RA upregulated expression of Bcl-2 and Bcl-xL RNA and protein, and this was associated with protection from etoposide-mediated apoptosis at the mitochondrial level. (aacrjournals.org)
- In the experiments described below, cell number was monitored three days post-transfection (Figure 3), or apoptosis was induced using etoposide one day after transfection, and caspase 3 activity was assayed three days post-transfection (Figure 4). (bio-medicine.org)
- 24 (4 Suppl 12): S12-144-S12-148) and Phase II (J Clin Oncol 1999 17: 2309) studies have shown that the combination of Paclitaxel-Cisplatin-Etoposide (TEP) was active in SCLC. (oncolink.org)
- ARM I: Patients receive paclitaxel intravenously (IV) over 3 hours and carboplatin IV over 1 hour on day 1. (osu.edu)
- To determine the response rate, progression-free survival and overall survival, and toxicity of paclitaxel, etoposide, and cisplatin combined with accelerated hyperfractionated thoracic radiotherapy in patients with limited-disease (LD) small-cell lung cancer (SCLC). (unboundmedicine.com)
- In cycle 1, chemotherapy consisted of paclitaxel 135 mg/m(2) intravenous over 3 hours on day 1, etoposide 60 mg/m(2) intravenous on day 1 and 80 mg/m(2) orally on days 2 and 3, and cisplatin 60 mg/m(2) intravenous on day 1. (unboundmedicine.com)
- In cycles 2 to 4, the paclitaxel dose was increased to 175 mg/m(2), with the etoposide and cisplatin doses remaining the same as in cycle 1. (unboundmedicine.com)
- Superiority of sequential versus concurrent administration of paclitaxel with etoposide in advanced non-small cell lung cancer: comparison of two Phase II trials. (aacrjournals.org)
- Paclitaxel and etoposide are two chemotherapy agents with broad cytotoxic activity and different mechanisms of action and resistance. (aacrjournals.org)
- We performed two sequential Phase II trials using different sequence schedules of paclitaxel and etoposide as first-line treatment in advanced non-small cell lung cancer (NSCLC). (aacrjournals.org)
- The first 20 patients (part A) also received paclitaxel at 175 mg/m2 as a 3-h infusion on day 1, immediately prior to etoposide. (aacrjournals.org)
- The subsequent 24 patients (part B) were given the same paclitaxel dose, but on day 4. (aacrjournals.org)
- In conclusion, toxicity and antitumor activity of the paclitaxel/etoposide combination may be sequence dependent. (aacrjournals.org)
- Our findings suggest that etoposide followed by paclitaxel is well tolerated and has greater activity in NSCLC than concurrent administration. (aacrjournals.org)
- The recommended dose of gemcitabine is 1,250 mg/m intravenously over 30 minutes on Days 1 and 8 of each 21-day cycle that includes paclitaxel. (bioportfolio.com)
- Paclitaxel should be administered at 175 mg/m on Day 1 as a 3 hour intravenous infusion before gemcitabine administration. (bioportfolio.com)
- Author comment: 'Therefore, the regimen was changed to cisplatin plus etoposide (EP) as the third-line chemotherapy. (deepdyve.com)
- A multi-center, open label phase I study with escalating doses of vorinostat in combination with etoposide was conducted to establish the safety of the combination in pediatric patients with refractory solid tumors to determine the maximum tolerated dose (MTD), dose limiting toxicity (DLT) and recommended phase II dose (RP2D) of this regimen. (aacrjournals.org)
- Correlate the extent of oxaliplatin and etoposide exposure with toxic effects and therapeutic effects of this regimen in these patients. (druglib.com)
- The standard five-day topotecan regimen (1.5 mg/m2/day) results in considerable bone marrow suppression in previously treated ovarian cancer patients, with 80% grade 4 neutropenia and 25% grade 4 thrombocytopenia [19- (dailystrength.org)
- Although this therapeutic regimen is effective in the treatment of patients with LD-SCLC, it is unlikely that the three-drug combination with thoracic radiation therapy will improve the survival times compared with the etoposide plus cisplatin chemotherapy regimen with thoracic radiation therapy in LD-SCLC patients. (unboundmedicine.com)
- The combination of i.p. topotecan and oral etoposide is an active and well-tolerated regimen in platinum-resistant ovarian carcinoma. (aacrjournals.org)
- Intravenous topotecan administered with the 5-day regimen is currently approved for the treatment of patients with relapsed ovarian cancer. (aacrjournals.org)
- A cost analysis of the oral regimen reveals that the oral Etoposide is very expensive making the overall costs seems higher with CCEP when compared to a common intravenous (lymphoma) regimen like CHOP. (aahpm.org)
Patients received etoposide2
- ARM B: Patients receive cisplatin intravenously (IV) on days 1-3 or carboplatin IV on day 1. (centerwatch.com)
- Actinomycin-D is given in a vein (intravenously, or IV) every day for 5 days, followed by several days without treatment. (cancer.org)
- etoposide (60 mg/m(2)/day) was injected intravenously over a 2 hour period on days 2, 3 and 4. (spandidos-publications.com)
- The recommended dose of gemcitabine is 1,000 mg/mas an intravenous infusion over 30 minutes on Days 1 and 8 of each 21-day cycle, in combination with carboplatin AUC 4 intravenously after gemcitabine administration on Day 1 of each 21-day cycle. (bioportfolio.com)
- The recommended dose of gemcitabine is 1,000 mg/m intravenously over 30 minutes on Days 1, 8, and 15 in combination with cisplatin therapy. (bioportfolio.com)
- Administer cisplatin intravenously at 100 mg/m on Day 1 after the infusion of gemcitabine. (bioportfolio.com)
- The chemo drug Etoposide was the only drug that doctor's said would work. (nbcnewyork.com)
- May 14, 2008 - High Dose Chemo May 22, 2008 - Stem Cell Rescue (34 days in isolated room in the hospital :( June 18, 2008 - Home! (caringbridge.org)
- My HCG came in at 360,000 so we started chemo (BEP) the next day (16 May). (tc-cancer.com)
- We have started the Chemo treatments with Carboplatin & etoposide. (cancer.org)
- It's a 21 day cycle, 3 days of chemo, 18 days off. (cancer.org)
- The first chemo is done and we are on day 5 of the 18 off. (cancer.org)
- Vorinostat was administered once daily for days 1-4 of the treatment cycle in escalating doses (125 mg/m 2 , 160 mg/m 2 , 210 mg/m 2 , and 270 mg/m 2 ). (aacrjournals.org)
- Doses in this protocol are expressed as etoposide. (eviq.org.au)
- Cohorts of 3-6 patients receive escalating doses of oxaliplatin and etoposide until the maximum tolerated dose (MTD) is determined. (druglib.com)
- Cycles were repeated every 28 days. (oncolink.org)
- For patients in the quizartinib arm, the median drug exposure was four cycles (range, 1 - 43 cycles) for a median of 97 days. (medscape.com)
- It is usually given in cycles, once a day or every other day, for up to 5 days. (rxwiki.com)
- Patients were treated with i.p. topotecan initial dose, 1 mg/m 2 on days 1 to 5, followed by oral etoposide 100 mg on days 6 to 9 of a 28-day cycle for six cycles. (aacrjournals.org)
- Le protocole du traitement se divise en deux phases : l'induction qui comporte deux cycles, puis la consolidation, qui en comprend trois. (aboutkidshealth.ca)
- Dr. Baker said 192 patients with favorable biology received four cycles of chemotherapy lasting 64 days and 275 with unfavorable biology received eight cycles over 168 days. (medpagetoday.com)
- During the treatment-induction phase, people received treatment on 21-day cycles for four cycles, followed by maintenance with Tecentriq or placebo until progressive disease (PD) as assessed by the investigator using Response Evaluation Criteria in Solid Tumours Version 1.1 (RECIST v1.1). (roche.com)
- Your nurse will give you etoposide as a drip (infusion) over an hour. (macmillan.org.uk)
- Day one - you have etoposide as a drip (infusion) over an hour and cisplatin as a drip (infusion). (macmillan.org.uk)
- Etoposide is given by intravenous (IV, into a vein) infusion. (oncolink.org)
- Shorter schedules (three daily treatments or a 24-h continuous infusion) are also under investigation, but may have less activity than the five-day schedule. (dailystrength.org)
- 2. Daunorubicin is given as an intravenous infusion given via a portable pump into your Hickman line over an hour on days 1, 3 and 5. (newcastle-hospitals.org.uk)
- The therapeutic effectiveness of continuous infusion of 5-fluorouracil and cisplatin, and etoposide (FEP) for treatment of metastatic gastric cancer was examined. (spandidos-publications.com)
- It is concluded that infusion of 5-fluorouracil, etoposide and cisplatin is effective and well tolerated. (spandidos-publications.com)
- bone marrow and/or peripheral blood progenitor cell (PBPC) infusion on day 0). (nature.com)
Effect of etoposide2
- The predominant macromolecular effect of etoposide appears to be the induction of DNA strand breaks by an interaction with DNA topoisomerase II or the formation of free radicals. (drugs.com)
- The effect of etoposide on DNA damage is potentiated by FK866 treatment, whereas the effect of FK866 on cytosolic NAD depletion is potentiated by etoposide. (aspetjournals.org)
Suggest that etoposide1
- Abstract B81: Phase I/II trial of vorinostat in combination with etoposide in pediatric patients with relapsed/refractory solid tumors. (aacrjournals.org)
- Conclusion: Vorinostat followed in combination with etoposide was found to be safe and well tolerated in children with refractory solid tumors. (aacrjournals.org)
- In previous studies, treatment of refractory cancer patients with etoposide associated with LDE had been shown devoid of toxicity. (dovepress.com)
- This phase I trial is studying the side effects and best dose of oxaliplatin and etoposide in treating young patients with recurrent or refractory solid tumors or lymphomas. (druglib.com)
- PRIMARY OBJECTIVES: I. Determine the maximum tolerated dose of oxaliplatin and etoposide in pediatric patients with recurrent or refractory solid tumors or lymphoma. (druglib.com)
- He discovered two important drugs: etoposide and ciclosporin. (wikipedia.org)
- Etoposide belongs to a group of drugs called podophyllotoxin derivatives, which slow or stop the growth of cancer cells. (rxwiki.com)
- Doctors and pharmacists say with generic cancer drugs like Etoposide, the problem is threefold: The expire quickly so can't be stored on shelves for long periods of time, they're complicated to make and don't make manufacturers much of a profit. (nbcnewyork.com)
- The inhibitory concentration of drugs (IC 99 ) increased from clinically achievable levels to nonachievable levels, greater than 5-fold (cisplatin) to greater than 7-fold (etoposide). (aacrjournals.org)
- Recruit 300 double blind random group separated SCLC patients currently used the Combined Chemotherapy on ETOPOSIDE INJECTION plus CISPLATIN INJECTION after local therapy with surgery, like as the usual approach group. (clinicaltrials.gov)
- Assay above every SCLC patient-specific Etoposide (VP-16) drug target (Topoisomerase II) SNP genotype in his or her SCLC cell whole genome DNA with precisely sequencing. (clinicaltrials.gov)
- Individualize or personalize etoposide chemotherapy toward small cell lung cancer (SCLC) with maximizing effectiveness via assay single nucleotide polymorphisms (SNPs) of relative etoposide target - topoisomerase II, and minimizing risk via assay single nucleotide polymorphisms (SNPs) of relative etoposide target - CYP4503A4, based on precisely sequencing drug targets' genes. (clinicaltrials.gov)
- The usual approach group, after local therapy with surgery, 300 double blind random group separated SCLC patients currently used the Combined Chemotherapy on ETOPOSIDE INJECTION plus CISPLATIN INJECTION, it will try to look for the relationship between the ETOPOSIDE INJECTION therapeutic efficacy and the Topoisomerase II SNP Genotyping, and the relationship between the ETOPOSIDE INJECTION therapeutic safety and the CYP4503A4 SNP Genotyping, based on precisely sequencing drug targets' genes. (clinicaltrials.gov)
- Etoposide is also approved to treat small cell lung cancer (SCLC). (rxwiki.com)
- The combination of etoposide (E) and cisplatin (P) is standard first line treatment for small cell lung cancer (SLSC). (oncolink.org)
- Certain types of neuroendocrine carcinomas may respond better to treatments other than the current standard treatment of cisplatin and etoposide. (centerwatch.com)
- Etoposide and cisplatin, known as EP (or sometimes PE), is a combination chemotherapy treatment used to treat different cancers. (macmillan.org.uk)
- Before or on the day of treatment, a nurse or person trained to take blood (phlebotomist) will take a blood sample from you. (macmillan.org.uk)
- At the end of the 21 days, you start your second cycle of treatment. (macmillan.org.uk)
- Fluorescence activated cell sorting (FACS) was used to analyse effects on cell cycle of the EBV infection as well as etoposide treatment. (deepdyve.com)
- FACS analysis indicated a strong G2/M block in both cell sublines after etoposide treatment. (deepdyve.com)
- These levels did not alter with etoposide treatment. (deepdyve.com)
- Bcl-XL was expressed endogenously in both cell lines and had reduced expression in EBV-negative cells after etoposide treatment. (deepdyve.com)
- Cisplatin/etoposide 2017-12-02 00:00:00 Reactions 1680, p88 - 2 Dec 2017 Haematological disorders and hair loss: case report An adult woman in her 30's [exact age at onset not stated] developed grade 4 neutropenia, grade 4 anaemia, grade 3 thrombocytopenia and grade 2 hair loss during treatment with cisplatin and etoposide [dosages, routes, time to reactions onsets and outcomes not stated]. (deepdyve.com)
- Etoposide was administered at a fixed dose of 100 mg/m 2 /day on days 3-5 of the treatment cycle. (aacrjournals.org)
- Each treatment cycle was 21 days. (aacrjournals.org)
- This study will summarize the safety of patients receiving figitumumab combined with etoposide and cisplatin (or carboplatin) vs. patients receiving etoposide and cisplatin (or carboplatin) alone as first line treatment for extensive stage disease Small Cell Lung Cancer. (clinicaltrials.gov)
- A phase II trial of pre-irradiation chemotherapy with BCNU, cisplatin and oral etoposide combined with radiation therapy in the treatment of glioblastoma (GBM) No significant improvement in survival rate with this pre-irradiation chemotherapy. (virtualtrials.com)
- Treatment: BCNU 40 mg/m2/d IV over one hour on days 1-3, VP-16 50 mg/d PO days 1-21 and 29-49, and cisplatin 20 mg/m2/d IV days 1-3 and 29-31. (virtualtrials.com)
- Each cycle has 8 days of drug treatment, followed usually by a 7-day rest period and then the cycle is repeated. (cancer.org)
- This method has more treatment days, so it may be less convenient. (cancer.org)
- It is given IV, every day for 3 to 5 days, followed by several days of treatment. (cancer.org)
- Treatment repeats every 21 days in the absence of unacceptable toxicity or disease progression. (druglib.com)
- After finishing treatment, patients are followed at 30 days. (druglib.com)
- Etoposide is still considered a potent, well-tolerated combination partner in innumerable hematologic and solid tumor treatment schedules, including those for malignant lymphomas and lung cancer. (wikipedia.org)
- Etoposide is a prescription medication used to treat cancer of the testicles that has not improved or that has worsened after surgery and treatment with other medications and radiation therapy. (rxwiki.com)
- The purpose is to investigate the safety and efficacy of i.p. topotecan and oral etoposide as salvage treatment for patients with platinum-resistant ovarian or primary peritoneal cancer. (aacrjournals.org)
- However, single-agent etoposide is not yet approved for the treatment of patients with relapsed ovarian cancer. (aacrjournals.org)
- When ulceration develops, treatment is mostly supportive until the cells regenerate themselves, which takes about 7 to 14 days. (cancersupportivecare.com)
- Etoposide is usually given as part of a 4-day or 5-day treatment cycle every 3 or 4 weeks. (cigna.com)
- The pt remained quadriparetic and ventilator dependent and died 75 days after chemotherapy treatment. (medalerts.org)
- Data from a randomized study in patients with non-small cell lung cancer treated with etoposide (in combination with cisplatin) support the use of etoposide for the treatment of this condition [Arriagada . (drugs.com)
- Additional data from a phase III trial in patients with stage IIIA non-small cell lung cancer with ipsilateral mediastinal nodal metastases also supports the use of etoposide (in combination with cisplatin and radiation therapy) for the treatment of this condition [Albain . (drugs.com)
- The hair falls out gradually 10 to 14 days following your first course of treatment. (newcastle-hospitals.org.uk)
- Initially hydration is the most important aspect of treatment, volumes of 3-4 litres per day have been used in adults, whilst children have received 3L/m 2 /day (Haupt et al, 1989), to reduce the risk of nephrotoxicity. (inchem.org)
- Treatment repeats every 28 days for 2 courses. (bioportfolio.com)
- The shorter duration of treatment represented a 70% reduction compared with conventional chemotherapy lasting 268 days, and eight-cycle treatment was 40% briefer. (medpagetoday.com)
- The total number of treatment days was reduced from 71 with conventional therapy to 10 for patients with favorable biology and 18 for those with unfavorable biology. (medpagetoday.com)
- Participants must have received one pre-registration cycle of platinum/etoposide chemotherapy prior to study entry, with study registration required within 21 days from day 1 of the pre-registration cycle of chemotherapy and protocol treatment designed to begin 21 days after. (moffitt.org)
- PURPOSE: This phase I trial is studying the side effects and best dose of sorafenib when given together with cisplatin and etoposide or carboplatin and pemetrexed in treating patients with metastatic solid tumors. (druglib.com)
- tosylate when administered in combination with cisplatin and etoposide or carboplatin and pemetrexed disodium in patients with metastatic solid tumors. (druglib.com)
- The five-day schedule can be inconvenient for patients and their families, however, the relative lack of acute toxicity makes topotecan a good candidate for home-based therapy in selected patients. (dailystrength.org)
- Peritoneal (topotecan) and plasma (topotecan and etoposide) levels were assessed at multiple time points using high-pressure liquid chromatography. (aacrjournals.org)
- Additional studies investigating topotecan in combination with etoposide are warranted. (aacrjournals.org)
- The role of etoposide as a specific topoisomerase II "poison" was further established by showing that its activity was downstream of a step controlled by aclarubicin, a topoisomerase II catalytic inhibitor. (aacrjournals.org)
- MK571, an MRP inhibitor, increased both the cell-to-medium ratio of etoposide and the etoposide sensitivity of MRP1-expressing stomach cancer cell lines. (aspetjournals.org)
- The antitumor activity of single-agent etoposide in patients with relapsed ovarian cancer has been investigated in several small phase II studies. (aacrjournals.org)
- (3) demonstrated that oral etoposide (50 mg/m 2 /day) has antitumor activity in both platinum-sensitive and -resistant patients. (aacrjournals.org)
- Etoposide is in a class of medications known as podophyllotoxin derivatives. (medlineplus.gov)
- tell your doctor and pharmacist if you are allergic to etoposide, any other medications, or any of the ingredients in etoposide capsules. (medlineplus.gov)
- Many other medications may also interact with etoposide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
- Etoposide is used in combination with other chemotherapy medications. (rxwiki.com)
- The cost of oral continuous therapy is based on 28 day month. (eviq.org.au)
- and oral sorafenib tosylate once or twice daily on days 1-21. (druglib.com)
- Additional studies are investigating the use of oral etoposide in combination with other agents in this patient population. (aacrjournals.org)
- To help prevent oral infections brush your teeth at least twice a day and drink plenty of fluids. (newcastle-hospitals.org.uk)
- The recommended phase II dose was established at vorinostat 270 mg/m 2 and etoposide 100 mg/m 2 and will be evaluated in an ongoing phase II study in pediatric patients with sarcoma. (aacrjournals.org)
- We therefore conducted a phase II trial of pre-irradiation BCNU, cisplatin and etoposide in patients with newly diagnosed GBM. (virtualtrials.com)
- Teniposide and etoposide were found by Stähelin to have a new mechanism of action: they blocked the entry of cells into mitosis (with arrest in late S or G2 phase), in contrast to SP-G and SP-I, which were spindle poisons. (wikipedia.org)
- Emetic episodes were recorded and nausea severity was assessed by patients beginning with the first chemotherapy dose, continuing until 24 h after the last chemotherapy dose (acute phase) and ending 7 days later (delayed phase). (springer.com)
- Etoposide has been shown to delay transit of cells through the S phase and arrest cells in late S or early G 2 phase. (drugs.com)
- Call your doctor for instructions if you miss an appointment for your etoposide injection. (cigna.com)
- Patients with histologically confirmed, previously untreated neoplasia, were treated with pIXY321 by subcutaneous injection at a dose of 375 microg/m2 twice daily (total dose 750 microg/m2/day) for seven days (days -8 to -2), followed by a two-day rest (days -1 to 0). (nih.gov)
- Here, we investigated the induction of Sirt1 expression by etoposide-induced genotoxic stress to gain insights into thyroid carcinogenesis and identify novel therapeutic targets. (spandidos-publications.com)
- The induction of Sirt1 and Sirt3 was cell type-specific and the expression levels of these genes correlated with apoptotic cell death and cell viability after etoposide-induced genotoxic stress. (spandidos-publications.com)
- Furthermore, we show that pretreatment of cells with aclarubicin (aclacinomycin A), eliminated the difference between BRCA-deficient and BRCA-proficient cells, proving that the observed etoposide sensitivity was due to the induction of the specialized DNA DSBs that arise by the action of the drug on the enzyme topoisomerase II ( 10 ). (aacrjournals.org)