DNA analogs containing neutral amide backbone linkages composed of aminoethyl glycine units instead of the usual phosphodiester linkage of deoxyribose groups. Peptide nucleic acids have high biological stability and higher affinity for complementary DNA or RNA sequences than analogous DNA oligomers.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Databases devoted to knowledge about specific genes and gene products.
Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
Nucleic acid which complements a specific mRNA or DNA molecule, or fragment thereof; used for hybridization studies in order to identify microorganisms and for genetic studies.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
Laboratory techniques that involve the in-vitro synthesis of many copies of DNA or RNA from one original template.
Databases containing information about NUCLEIC ACIDS such as BASE SEQUENCE; SNPS; NUCLEIC ACID CONFORMATION; and other properties. Information about the DNA fragments kept in a GENE LIBRARY or GENOMIC LIBRARY is often maintained in DNA databases.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Extensive collections, reputedly complete, of references and citations to books, articles, publications, etc., generally on a single subject or specialized subject area. Databases can operate through automated files, libraries, or computer disks. The concept should be differentiated from DATABASES, FACTUAL which is used for collections of data and facts apart from bibliographic references to them.
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Sequential operating programs and data which instruct the functioning of a digital computer.
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
Organized activities related to the storage, location, search, and retrieval of information.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Software designed to store, manipulate, manage, and control data for specific uses.
The portion of an interactive computer program that issues messages to and receives commands from a user.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
An isothermal in-vitro nucleotide amplification process. The process involves the concomitant action of a RNA-DIRECTED DNA POLYMERASE, a ribonuclease (RIBONUCLEASES), and DNA-DIRECTED RNA POLYMERASES to synthesize large quantities of sequence-specific RNA and DNA molecules.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Ribonucleic acid that makes up the genetic material of viruses.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Deoxyribonucleic acid that makes up the genetic material of viruses.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A single chain of deoxyribonucleotides that occurs in some bacteria and viruses. It usually exists as a covalently closed circle.
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
The systematic study of the complete DNA sequences (GENOME) of organisms.
Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.
Nucleotide sequences, generated by iterative rounds of SELEX APTAMER TECHNIQUE, that bind to a target molecule specifically and with high affinity.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.
Databases devoted to knowledge about specific chemicals.
The relationships of groups of organisms as reflected by their genetic makeup.
Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Double-stranded nucleic acid molecules (DNA-DNA or DNA-RNA) which contain regions of nucleotide mismatches (non-complementary). In vivo, these heteroduplexes can result from mutation or genetic recombination; in vitro, they are formed by nucleic acid hybridization. Electron microscopic analysis of the resulting heteroduplexes facilitates the mapping of regions of base sequence homology of nucleic acids.
Integrated set of files, procedures, and equipment for the storage, manipulation, and retrieval of information.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.
The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.
Activities performed to identify concepts and aspects of published information and research reports.
Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.
A group of 13 or more ribonucleotides in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.
The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Molecules of DNA that possess enzymatic activity.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.
Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.
MOLECULAR BIOLOGY techniques used in the diagnosis of disease.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The rate dynamics in chemical or physical systems.
Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
DNA or RNA bound to a substrate thereby having fixed positions.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.
The reformation of all, or part of, the native conformation of a nucleic acid molecule after the molecule has undergone denaturation.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
The most common form of DNA found in nature. It is a right-handed helix with 10 base pairs per turn, a pitch of 0.338 nm per base pair and a helical diameter of 1.9 nm.
A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)
A method of generating a large library of randomized nucleotides and selecting NUCLEOTIDE APTAMERS by iterative rounds of in vitro selection. A modified procedure substitutes AMINO ACIDS in place of NUCLEOTIDES to make PEPTIDE APTAMERS.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Systems where the input data enter the computer directly from the point of origin (usually a terminal or workstation) and/or in which output data are transmitted directly to that terminal point of origin. (Sippl, Computer Dictionary, 4th ed)
The use of devices which use detector molecules to detect, investigate, or analyze other molecules, macromolecules, molecular aggregates, or organisms.
A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)
The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.
Specific languages used to prepare computer programs.
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
A multistage process that includes cloning, physical mapping, subcloning, sequencing, and information analysis of an RNA SEQUENCE.
Enzymes that catalyze the hydrolysis of ester bonds within RNA. EC 3.1.-.
Elements of limited time intervals, contributing to particular results or situations.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
Proteins found in any species of virus.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.
A group of ribonucleotides (up to 12) in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
RNA, usually prepared by transcription from cloned DNA, which complements a specific mRNA or DNA and is generally used for studies of virus genes, distribution of specific RNA in tissues and cells, integration of viral DNA into genomes, transcription, etc. Whereas DNA PROBES are preferred for use at a more macroscopic level for detection of the presence of DNA/RNA from specific species or subspecies, RNA probes are preferred for genetic studies. Conventional labels for the RNA probe include radioisotope labels 32P and 125I and the chemical label biotin. RNA probes may be further divided by category into plus-sense RNA probes, minus-sense RNA probes, and antisense RNA probes.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Methods for determining interaction between PROTEINS.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.
Topical antiseptic used mainly in wound dressings.
Proteins found in any species of bacterium.
A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.
A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)
An optical disk storage system for computers on which data can be read or from which data can be retrieved but not entered or modified. A CD-ROM unit is almost identical to the compact disk playback device for home use.
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A publication issued at stated, more or less regular, intervals.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
Established cell cultures that have the potential to propagate indefinitely.
The most abundant form of RNA. Together with proteins, it forms the ribosomes, playing a structural role and also a role in ribosomal binding of mRNA and tRNAs. Individual chains are conventionally designated by their sedimentation coefficients. In eukaryotes, four large chains exist, synthesized in the nucleolus and constituting about 50% of the ribosome. (Dorland, 28th ed)
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Specifications and instructions applied to the software.
A group of 13 or more deoxyribonucleotides in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
Computer-based representation of physical systems and phenomena such as chemical processes.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
The biosynthesis of DNA carried out on a template of RNA.
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
The chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (ANABOLISM) and the breakdown (CATABOLISM) of organic materials utilized by the living organism.
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A pyrimidine base that is a fundamental unit of nucleic acids.
Controlled operation of an apparatus, process, or system by mechanical or electronic devices that take the place of human organs of observation, effort, and decision. (From Webster's Collegiate Dictionary, 1993)
Enzymes which catalyze the hydrolases of ester bonds within DNA. EC 3.1.-.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Techniques used in studying bacteria.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.
A ribonuclease that specifically cleaves the RNA moiety of RNA:DNA hybrids. It has been isolated from a wide variety of prokaryotic and eukaryotic organisms as well as RETROVIRUSES.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
RNA consisting of two strands as opposed to the more prevalent single-stranded RNA. Most of the double-stranded segments are formed from transcription of DNA by intramolecular base-pairing of inverted complementary sequences separated by a single-stranded loop. Some double-stranded segments of RNA are normal in all organisms.
Any method used for determining the location of and relative distances between genes on a chromosome.
Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
The presence of DNA from a source foreign to the sample being analysed.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
The influence of study results on the chances of publication and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
A group of guanine ribonucleotides in which the phosphate residues of each guanine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Measurement of the intensity and quality of fluorescence.
Nucleic acids which hybridize to complementary sequences in other target nucleic acids causing the function of the latter to be affected.
Modified oligonucleotides in which one of the oxygens of the phosphate group is replaced with a sulfur atom.
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
A pentose active in biological systems usually in its D-form.
The small RNA molecules, 73-80 nucleotides long, that function during translation (TRANSLATION, GENETIC) to align AMINO ACIDS at the RIBOSOMES in a sequence determined by the mRNA (RNA, MESSENGER). There are about 30 different transfer RNAs. Each recognizes a specific CODON set on the mRNA through its own ANTICODON and as aminoacyl tRNAs (RNA, TRANSFER, AMINO ACYL), each carries a specific amino acid to the ribosome to add to the elongating peptide chains.
The degree of similarity between sequences. Studies of AMINO ACID SEQUENCE HOMOLOGY and NUCLEIC ACID SEQUENCE HOMOLOGY provide useful information about the genetic relatedness of genes, gene products, and species.
The protein complement of an organism coded for by its genome.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
A series of steps taken in order to conduct research.
Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.
The systematic study of the complete complement of proteins (PROTEOME) of organisms.
An isoform of DNA that occurs in an environment rich in SODIUM and POTASSIUM ions. It is a right-handed helix with 11 base pairs per turn, a pitch of 0.256 nm per base pair and a helical diameter of 2.3 nm.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.
Systematic organization, storage, retrieval, and dissemination of specialized information, especially of a scientific or technical nature (From ALA Glossary of Library and Information Science, 1983). It often involves authenticating or validating information.
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).
The presence of an uncomplimentary base in double-stranded DNA caused by spontaneous deamination of cytosine or adenine, mismatching during homologous recombination, or errors in DNA replication. Multiple, sequential base pair mismatches lead to formation of heteroduplex DNA; (NUCLEIC ACID HETERODUPLEXES).
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).

Genetic testing: a conceptual exploration. (1/2093)

This paper attempts to explore a number of conceptual issues surrounding genetic testing. It looks at the meaning of the terms, genetic information and genetic testing in relation to the definition set out by the Advisory Committee on Genetic Testing in the UK, and by the Task Force on Genetic Testing in the USA. It argues that the special arrangements that may be required for the regulation of genetic tests should not be determined by reference to the nature or technology of the test, but by considering those morally relevant features that justify regulation. Failure to do so will lead to the regulation of genetic tests that need not be regulated, and would fail to cover other tests which should be regulated. The paper also argues that there is little in the nature of the properties of gene tests, using DNA or chromosomes, that in itself justifies a special approach.  (+info)

Indigenous peoples and the morality of the Human Genome Diversity Project. (2/2093)

In addition to the aim of mapping and sequencing one human's genome, the Human Genome Project also intends to characterise the genetic diversity of the world's peoples. The Human Genome Diversity Project raises political, economic and ethical issues. These intersect clearly when the genomes under study are those of indigenous peoples who are already subject to serious economic, legal and/or social disadvantage and discrimination. The fact that some individuals associated with the project have made dismissive comments about indigenous peoples has confused rather than illuminated the deeper issues involved, as well as causing much antagonism among indigenous peoples. There are more serious ethical issues raised by the project for all geneticists, including those who are sympathetic to the problems of indigenous peoples. With particular attention to the history and attitudes of Australian indigenous peoples, we argue that the Human Genome Diversity Project can only proceed if those who further its objectives simultaneously: respect the cultural beliefs of indigenous peoples; publicly support the efforts of indigenous peoples to achieve respect and equality; express respect by a rigorous understanding of the meaning of equitable negotiation of consent, and ensure that both immediate and long term economic benefits from the research flow back to the groups taking part.  (+info)

Ethics in the laboratory examination of patients. (3/2093)

Various value problems are connected with the clinical examination of patients. The purpose of this literature review is to clarify: 1) in which patient examinations ethical problems are generally found; 2) what kind of ethical problems are found in the different phases of the examination process, and 3) what kind of ethical problems are found in connection with the use of examination results. Genetic testing, autopsy, prenatal and HIV examinations were ethically the most problematic laboratory examinations. The most problematic phase in the laboratory examination process proved to be the pre-analytic phase. At present the results of laboratory examination are used more and more often for the prediction of diseases. The problems appear when the examination results are used for discrimination and stigmatization. Because of the lack of empirical ethical research, it is important to chart empirical knowledge about present value conflict situations involved in the laboratory examination process.  (+info)

Ethical-legal problems of DNA databases in criminal investigation. (4/2093)

Advances in DNA technology and the discovery of DNA polymorphisms have permitted the creation of DNA databases of individuals for the purpose of criminal investigation. Many ethical and legal problems arise in the preparation of a DNA database, and these problems are especially important when one analyses the legal regulations on the subject. In this paper three main groups of possibilities, three systems, are analysed in relation to databases. The first system is based on a general analysis of the population; the second one is based on the taking of samples for a particular list of crimes, and a third is based only on the specific analysis of each case. The advantages and disadvantages of each system are compared and controversial issues are then examined. We found the second system to be the best choice for Spain and other European countries with a similar tradition when we weighed the rights of an individual against the public's interest in the prosecution of a crime.  (+info)

Separating real motifs from their artifacts. (5/2093)

The typical output of many computational methods to identify binding sites is a long list of motifs containing some real motifs (those most likely to correspond to the actual binding sites) along with a large number of random variations of these. We present a statistical method to separate real motifs from their artifacts. This produces a short list of high quality motifs that is sufficient to explain the over-representation of all motifs in the given sequences. Using synthetic data sets, we show that the output of our method is very accurate. On various sets of upstream sequences in S. cerevisiae, our program identifies several known binding sites, as well as a number of significant novel motifs.  (+info)

Gene recognition based on DAG shortest paths. (6/2093)

We describe DAGGER, an ab initio gene recognition program which combines the output of high dimensional signal sensors in an intuitive gene model based on directed acyclic graphs. In the first stage, candidate start, donor, acceptor, and stop sites are scored using the SNoW learning architecture. These sites are then used to generate a directed acyclic graph in which each source-sink path represents a possible gene structure. Training sequences are used to optimize an edge weighting function so that the shortest source-sink path maximizes exon-level prediction accuracy. Experimental evaluation of prediction accuracy on two benchmark data sets demonstrates that DAGGERis competitive with ab initio gene finding programs based on Hidden Markov Models.  (+info)

Design of a compartmentalized shotgun assembler for the human genome. (7/2093)

Two different strategies for determining the human genome are currently being pursued: one is the "clone-by-clone" approach, employed by the publicly funded project, and the other is the "whole genome shotgun assembler" approach, favored by researchers at Celera Genomics. An interim strategy employed at Celera, called compartmentalized shotgun assembly, makes use of preliminary data produced by both approaches. In this paper we describe the design, implementation and operation of the "compartmentalized shotgun assembler".  (+info)

Joint modeling of DNA sequence and physical properties to improve eukaryotic promoter recognition. (8/2093)

We present an approach to integrate physical properties of DNA, such as DNA bendability or GC content, into our probabilistic promoter recognition system McPROMOTER. In the new model, a promoter is represented as a sequence of consecutive segments represented by joint likelihoods for DNA sequence and profiles of physical properties. Sequence likelihoods are modeled with interpolated Markov chains, physical properties with Gaussian distributions. The background uses two joint sequence/profile models for coding and non-coding sequences, each consisting of a mixture of a sense and an anti-sense submodel. On a large Drosophila test set, we achieved a reduction of about 30% of false positives when compared with a model solely based on sequence likelihoods.  (+info)

The European Nucleotide Archive (ENA) provides a comprehensive record of the worlds nucleotide sequencing information, covering raw sequencing data, sequence assembly information and functional annotation. ENA is developed and operated by the EMBL-European Bioinformatics Institute (EMBL-EBI), an academic research institute based in the UK and part of the European Molecular Biology Laboratory (EMBL). ENA is one of the three databases that make up the International Nucleotide Sequence Database Collaboration (INSDC).. GFBio Data Center. The EBI is a world-renowned center for research and services in bioinformatics and is the European node for globally coordinated efforts to collect and disseminate biological data. The EBI operates as the central hub of the intra-European infrastructure Elixir, whose goal is to orchestrate the collection, quality control and archiving of large amounts of biological data produced by life science experiments. As such, the EBIs mission is to ensure that the growing ...
UniProt - Swiss-Prot Protein Knowledgebase SIB Swiss Institute of Bioinformatics; Geneva, Switzerland European Bioinformatics Institute (EBI); Hinxton, United Kingdom Protein Information Resource (PIR); Washington DC, USA ---------------------------------------------------------------------------- Description: Generalised protein naming guidelines Name: gennameprot.txt Release: 2017_12 of 20-Dec-2017 ---------------------------------------------------------------------------- This is a subset of the UniProtKB document nameprot.txt which has been developed with the International Nucleotide Sequence Database Collaboration (INSDC) (www.insdc.org) to provide guidelines for their submitters. Glossary ======== RN : Recommended name (RecName) AN : Alternative name (AltName) GS : Gene symbol OLN: Ordered locus name General naming rules ==================== If it exists, use the approved nomenclature. See: nomlist.txt (http://www.uniprot.org/docs/nomlist), a list of nomenclature related references for ...
This list of sequenced eubacterial genomes contains all the eubacteria known to have publicly available complete genome sequences. Most of these sequences have been placed in the International Nucleotide Sequence Database Collaboration, a public database which can be seKarched on the web. A few of the listed genomes may not be in the INSDC database, but in other public databases[verification needed]. Genomes listed as Unpublished are in a database, but not in the peer-reviewed scientific literature. For the genomes of archaea see list of sequenced archaeal genomes. Genome project Human microbiome project List of sequenced eukaryotic genomes List of sequenced archaeal genomes List of sequenced plastomes Entrez Genome Database Search. National Center for Biotechnology Information. Search for details on specific genomes by organism name and strain. Schell MA, et al. (2002). The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract. Proc. Natl. ...
The NCBI taxonomy database provides the organism nomenclature and classification that is used in sequence entries by the International Nucleotide Sequence Database Collaboration (INSDC [1]; comprising GenBank, ENA and the DDBJ) [2]. The NCBI Taxonomy Group is responsible for curating names for taxa that are regulated by the relevant codes of nomenclature [3-5], for providing informal names for specimens that are not identified with Linnaean species binomials, and for maintaining the taxid namespace. This is a labor-intensive and largely manual effort undertaken by this small group of diligent and dedicated taxonomists at the NCBI [6].. It has been almost twenty years since the first bacterial genomes started to appear in the sequence databases, beginning with Haemophilus influenzae in 1995, followed within a year by Escherichia coli. In those days each new genome sequence was of significant scientific interest and represented a considerable technical achievement. At that time, for the ...
Genome sequences nowadays play a central role in molecular biology and bioinformatics. These sequences are shared with the scientific community through sequence databases. The sequence repositories of the International Nucleotide Sequence Database Collaboration (INSDC, comprising GenBank, ENA and DDBJ) are the largest in the world. Preparing an annotated sequence in such a way that it will be accepted by the database is challenging because many validation criteria apply. In our opinion, it is an undesirable situation that researchers who want to submit their sequence need either a lot of experience or help from partners to get the job done. To save valuable time and money, we list a number of recommendations for people who want to submit an annotated genome to a sequence database, as well as for tool developers, who could help to ease the process ...
GenBank is the NIH genetic sequence database, an annotated collection of all publicly available DNA sequences. GenBank is part of the International Nucleotide Sequence Database Collaboration, which comprises the DNA DataBank of Japan (DDBJ), the European Molecular Biology Laboratory (EMBL), and GenBank at NCBI. These three organizations exchange data on a daily basis. The complete release notes for the current version of GenBank are available on the NCBI ftp site. A new release is made every two months. GenBank growth statistics for both the traditional GenBank divisions and the WGS division are available from each release ...
Oligonucleotide frequencies were used to compute distances among completely sequenced genomes within a genera and to cluster them. The resulting dendrograms are available by selecting the genera in the right. These comparisons are provided as examples of the clustering power of oligonucleotides and to show the potencial of this method to cluster together related genomes. This method may be used even for typing within same species. The sequenced used in this service were obtained from Release 35 (by EMBL-EBI). This releases includes the latest versions of 44,039 genomes (43,552 bacteria and 494 archaea) from the The International Nucleotide Sequence Database Collaboration (INSDC) archives. Comparison is only available when at least 5 genomes are vailable within the genera or species. Show more ...
The NIH genetic sequence database, an annotated collection of all publicly available DNA sequences. GenBank is part of the International Nucleotide Sequence Database Collaboration, which comprises the DNA DataBank of Japan (DDBJ), the European Molecular Biology Laboratory (EMBL), and GenBank at NCBI. These three organizations exchange data on a daily basis. GenBank consists of several divisions, most of which can be accessed through the Nucleotide database. The exceptions are the EST and GSS divisions, which are accessed through the Nucleotide EST and Nucleotide GSS databases, respectively.. ...
Well, it seems that the Sequence Read Archive (SRA) is going away sometime in the near future. I posted about the SRA last week and in the discussion someone posted an email message that supposedly was from David Lipman of the NCBI saying that the SRA is going to be closing. This has now been confirmed and I thought I would just post some links discussing ...
The CIB-DDBJ constructs the database, named H-Invitational Database CIB-DDBJ Flat File Server, to release and get a results on functional annotation assigned to full-length cDNA in flat file compatible with the DDBJ flat file format of International Nucleotide Sequence Database with some modification. The Flat Files were prepared by both CIB-DDBJ and JBIRC, called as DDBJ version Flat File and JBIRC version Flat File, respectively, and XML Files was also only made by JBIRC for all of cDNA and LOCUS entries ...
Greetings GenBank Users, This topic is not directly related to GenBank Release/Update content, or to the GenBank flatfile format, but it is still probably appropriate for this group. Some of you may know that DDBJ, EMBL, and GenBank have developed an XML DTD for sequence records called INSDSeq . The purpose of INSDSeq is to provide a near-uniform representation for sequence records from all three participants in the International Nucleotide Sequence Database (INSD) collaboration. As it currently stands, INSDSeq does not provide very much structure beyond what users are already familiar with from the GenBank, EMBL, and DDBJ flatfile formats. An example of a GenBank record in INSDSeq format can be viewed at this URL: http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&qty=1&c_start=1&list_uids=146274&dopt=gbc Although elements like INSDInterval have been defined to create a more easily parsable structure for feature locations, overall INSDSeq is clearly still wedded to the flatfile ...
Transcription Support Level (TSL): It is important that users understand how to assess transcript annotations that they see in GENCODE. While some transcript models have a high level of support through the full length of their exon structure, there are also transcripts that are poorly supported and that should be considered speculative. The Transcription Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.. The mRNA and EST alignments are compared to the GENCODE transcripts and the transcripts are scored according to how well the alignment matches over its full length. The GENCODE TSL provides a consistent method of evaluating the level of support that a GENCODE transcript annotation is actually expressed in humans. Human transcript sequences from the International Nucleotide Sequence Database ...
Transcription Support Level (TSL): It is important that users understand how to assess transcript annotations that they see in GENCODE. While some transcript models have a high level of support through the full length of their exon structure, there are also transcripts that are poorly supported and that should be considered speculative. The Transcription Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.. The mRNA and EST alignments are compared to the GENCODE transcripts and the transcripts are scored according to how well the alignment matches over its full length. The GENCODE TSL provides a consistent method of evaluating the level of support that a GENCODE transcript annotation is actually expressed in mouse. Mouse transcript sequences from the International Nucleotide Sequence Database ...
Some searches can take several minutes, especially if you are searching against a large set of sequences (e.g. all assembled and annotated sequences). As a visual cue to let you know that a search is still running, we display an ENA loading icon in the place of the submit button and block the sequence search form from any editing. Once the search is complete, this icon will disappear, the submit button will return and you should also have a new window open with the search results. If you have the pop-up blocker enabled, you will need to disable it to get the results window. Alternatively, you can select the option to receive an email with a link to the results once the search is complete. ...
Thörnqvist L, Ohlin M Data Brief 19 (-) 337-352 [2018-08-00; online 2018-05-04] The highly variable complementary determining region 3 (CDR3) of antibodies is generated through recombination of immunoglobulin heavy chain variable (IGHV), diversity, and joining genes. The codons encoding the first residues of CDR3 may be derived directly from the IGHV germline gene but they may also be generated as part of the rearrangement process. Data of the nucleotide composition of these codons of rearranged genes, an indicator of the degree of contribution of the IGHV gene to CDR3 diversity, are presented in this article. Analyzed data are presented for two unrelated sets of raw sequence data. The raw data sets consisted of sequences of antibody heavy chain-encoding transcripts of six allergic subjects (European Nucleotide Archive accession number PRJEB18926), and paired antibody heavy and light chain variable region-encoding transcripts of memory B cells of three subjects (European Nucleotide Archive ...
The Sequence Read Archive (SRA) stores raw sequence data from next-generation sequencing technologies including Illumina, 454, IonTorrent, Complete Genomics, PacBio and OxfordNanopores. In addition to raw sequence data, SRA now stores alignment information in the form of read placements on a reference sequence. SRA is NIHs primary archive of high-throughput sequencing data and is part of the international partnership of archives (INSDC) at the NCBI, the European Bioinformatics Institute and the DNA Database of Japan. Data submitted to any of the three organizations are shared among them. Please check SRA Overview for more information. ...
Ensembl Genomes provides genomic variation data, including single nucleotide polymorphisms(SNPs) and insertion-deletion mutations (indels) from various sources, for which any effects on transcripts in the area are calculated. In Ensembl Genomes variant data is imported from EBI resources such as the European Variation Archive (EVA) or the European Nucleotide Archive (ENA) and from a range of third parties. The exact source of variant data is provided on the information page for each genome in the Ensembl browser (e.g. A. thaliana). Ensembl Genomes uses the Ensembl variation platform for data storage and display/dissemination ...
In view of recent discussions on the biosci bulletin-boards about changes to database formats, I am posting here text extracted from the release notes of the upcoming release of the EMBL Nucleotide Sequence Database (Rel 24, Aug 90). Peter Stoehr EMBL Data Library ----------------------------------------------------------------------------- 1 CHANGES AT THIS RELEASE (Release 24, August 1990) 1.1 New Feature Table Experience in trying to represent some of the more complex features of nucleotide sequences led both ourselves and GenBank to the conclusion that the old style of feature table was inadequate. EMBL, GenBank and the DNA Data Bank of Japan have completed the design of a new, common, feature table format which we are introducing at this release. If you would like to receive details of the new feature table format then please contact us (by post, telephone or electronic mail) at the address shown on the cover page of this document. A brief introduction to the new format is supplied as the ...
This session provides an introduction to the European Nucleotide Archive (ENA) record of the worlds nucleotide sequencing information, covering raw sequencing data, sequence assembly information and functional annotation available from the Europian Bioinformatics Institute (EBI). Further information for this session is available here. This session is one of a series of short introductions to EBI Services, run together, but bookable separately (see Related Courses section below). Please note that if you are not eligible for a University of Cambridge Raven account you will need to book by linking here.. ...
Times Cited Count:50 Percentile:22.27(Biochemistry & Molecular Biology). Here we report the new features and improvements in our latest release of the H-Invitational Database, a comprehensive annotation resource for human genes and transcripts. H-InvDB, originally developed as an integrated database of the human transcriptome based on extensive annotation of large sets of fulllength cDNA (FLcDNA) clones, now provides annotation for 120 558 human mRNAs extracted from the International Nucleotide Sequence Databases (INSD), in addition to 54 978 human FLcDNAs, in the latest release H-InvDB. We mapped those human transcripts onto the human genome sequences (NCBI build 36.1) and determined 34 699 human gene clusters, which could define 34 057 protein-coding and 642 non-protein-coding loci; 858 transcribed loci overlapped with predicted pseudogenes.. ...
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As we have previously relayed in these daily updates, information during this crisis can change moment to moment. Late yesterday afternoon, one of those moments occurred within an hour of our release of the April 8th daily update. By 7:00pm, when Mike Handler made his nightly public information update to residents of New Canaan, another of our beloved Village residents had passed at a local hospital. This was an unintended consequence of our effort to get out a daily update earlier in the day. In light of this, as of today, we are aiming for a 6:00 pm daily update release from Waveny.. , Read More ...
You need SRA Toolkit to operate on SRA runs. Default toolkit configuration enables it to find and retrieve SRA runs by accession. It also downloads (and cache) only the part of data you really need. For example quality scores represent a majority of data volume and you may not need them if you dump fasta only (versus fastq). Or if you are looking at particular gene you may not need reads aligned to other regions or not aligned at all. Same way if you use GATK with enabled SRA support you need only SRA run accessions to fire your process. fastq-dump will dump reads in a number of standard fastq and fasta formats. vdb-dump is also capable of producing fasta and fastq (beside other formats). It dumps data much faster then fastq-dump but ordering of reads may be different and it does not produce split-read multi-file output. Prefetch tool will help you cache all data in advance if you plan to run data analysis in environment where getting data from NCBI at run time is unfeasible. To select a list ...
MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, the location of modified residues in RNA sequences, and RNA-modifying enzymes.
MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, the location of modified residues in RNA sequences, and RNA-modifying enzymes.
In the BASE COUNT line of the DDBJ flat file, 9 digits are allocated for each number of a (adenine), c (cytosine), g (guanine) and t (thymine). In the case of RNA sequence, uracil is indicated as t according to the rule of the international nucleotide databases collaboration. The nucleotide symbol is defined in Nucleotide Base Codes.In accordance with the relaxation of sequence length limitation, GenBank had already dropped the BASE COUNT line from their flat file format from GenBank Release 138 (Oct. 2003). DDBJ has decided to maintain the BASE COUNT line in our flat file format from the view that GC contents are still important information to characterize the sequence.. ...
General Guidelines Submissions are welcomed via Submittable. Simultaneous submissions are acceptable and encouraged. For fiction especially, if your work is accepted elsewhere (congratulations!), p… Source: Submit
An archive of the daily updates for students of the MD Program during the COVID-19 pandemic.. The following daily updates were sent to MD Program students in March & April, 2020 during the COVID-19 pandemic.. ...
Adam Hewison, charting strategist of INO.com, brings you another edition of his invaluable service of daily technical updates on the ups and downs of various markets. This short analysis is a great tool for keeping ones finger on the pulse and timing the markets.. Click the image below to hear his latest views on gold (short-, medium- and long-term buy), silver (more recovery potential, possibly to $42), the US Dollar Index (not much more short-term upside potential, long term negative), the CRB Index (in a tight trading range), crude oil (strong support at $96, needs to break $100 to enter uptrend), and the S&P 500 Index (primary trend up, but in a short-term trading range with support at 1,295/1,300). Also, click here to have an instant analysis of any ticker symbol in your portfolio performed by INO.com.. [iframe: width=520″ height=318″ src=http://www.ino.com/info/688/CD3194/&dp=0&l=0&campaignid=3″ style=border:0;outline:0″ frameborder=0″ scrolling=no] ...
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Is the Fed solvent?. Read this (several times), quoted verbatim from John Mauldin:. As a side note, its probably worth noting that the Federal Reserve has already pushed its balance sheet to a point where it is leveraged 50-to-1 against its capital ($2.65 trillion / $52.6 billion in capital as reported the Feds consolidated balance sheet ). This is a greater leverage ratio than Bear Stearns or Fannie Mae, with similar interest rate risk but less default risk. The Fed holds roughly $1.3 trillion in Treasury debt, $937 billion in mortgage securities by Fannie and Freddie, $132 billion of direct obligations of Fannie, Freddie and the FHLB, and nearly $80 billion in TIPS and T-bills. The maturity distribution of these assets works out to an average duration of about 6 years, which implies that the Fed would lose roughly 6% in value for every 100 basis points higher in long-term interest rates. Given that the Fed only holds 2% in capital against these assets, a 35-basis point increase in long-term ...
Popenda, M., Szachniuk, M., Blazewicz, M., Wasik, S., Burke, E.K., Blazewicz, J., Adamiak, R.W. RNA FRABASE 2.0: an advanced web-accessible database with the capacity to search the three-dimensional fragments within RNA structures. BMC Bioinformatics, 2010, 11:231 (doi:10.1186/1471-2105-11-231 ...
The authors of RFC 2476 and draft-gellens-submit-bis are requesting that Message Submission be promoted to Draft Standard. Message Submission Interoperability Report Randall Gellens (Qualcomm) January 19, 2005 Version 1.0 Message Submission as specified by RFC 2476 has seen widespread deployment. Many email servers now support Message Submission, and many clients comply with it. Note that draft-gellens-submit-bis has one substantive change from RFC 2476: use of SMTP AUTH is now mandatory. Interworking Report: The servers known to support Message Submission are known to work with multiple clients, including when such clients are configured to use port 587 for message submission. Detailed Implementation Report: Port 587: Many email servers now support listening on port 587, including sendmail ...
Copyright 2007 by Peter Cock. All rights reserved. # This code is part of the Biopython distribution and governed by its # license. Please see the LICENSE file that should have been included # as part of this package. # # This code is NOT intended for direct use. It provides a basic scanner # (for use with a event consumer such as Bio.GenBank._FeatureConsumer) # to parse a GenBank or EMBL file (with their shared INSDC feature table). # # It is used by Bio.GenBank to parse GenBank files # It is also used by Bio.SeqIO to parse GenBank and EMBL files # # Feature Table Documentation: # http://www.insdc.org/files/feature_table.html # http://www.ncbi.nlm.nih.gov/projects/collab/FT/index.html # ftp://ftp.ncbi.nih.gov/genbank/docs/ import sys from Bio.Seq import Seq from Bio.SeqRecord import SeqRecord from Bio.Alphabet import generic_alphabet, generic_protein 00023 class InsdcScanner : Basic functions for breaking up a GenBank/EMBL file into sub sections. The International Nucleotide Sequence ...
Nater, A. (Creator), Mattle-Greminger, M. P. (Creator), Nurcahyo, A. (Creator), Nowak, M. G. (Creator), de Manuel, M. (Creator), Desai, T. (Creator), Groves, C. (Creator), Pybus, M. (Creator), Bilgin Sonay, T. (Creator), Roos, C. (Creator), Reis e Lameira, A. (Creator), Wich, S. A. (Creator), Askew, J. (Creator), Davila-Ross, M. (Creator), Fredriksson, G. (Creator), de Valles, G. (Creator), Casals, F. (Creator), Prado-Martinez, J. (Creator), Goossens, B. (Creator), Verschoor, E. J. (Creator), Warren, K. S. (Creator), Singleton, I. (Creator), Marques, D. A. (Creator), Pamungkas, J. (Creator), Perwitasari-Farajallah, D. (Creator), Rianti, P. (Creator), Tuuga, A. (Creator), Gut, I. G. (Creator), Gut, M. (Creator), Orozco-terWengel, P. (Creator), van Schaik (Carel P van Schaik), C. P. (Creator), Bertranpetit, J. (Creator), Anisimova, M. (Creator), Scally, A. (Creator), Marques-Bonet, T. (Creator), Meijaard, E. (Creator), Krützen, M. (Creator), European Nucleotide Archive (ENA), 1 Nov ...
The European Bioinformatics Institute recently scooped the award for Best Datacentre Project at the CW European User Awards, and heres why
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Via RTHK: Govt to hold daily updates on mystery illness. The full report and then a comment: The government has unveiled precautionary measures its taken in response to an outbreak of pneumonia cases in Wuhan, including daily briefings. On New...
Referring to the sequence analysis results of the Department of Biomedical Molecular Biology (Ghent University, Belgium), the nucleotide sequence of the wild type mouse A20 cDNA corresponds with the EMBL Nucleotide Sequence Database accession number U19463.1, except for nucleotide position 2096 of the coding sequence: the T-residue is substituted by a C- residue, resulting in a Leu/Pro replacement ...
Supplementary MaterialsAdditional file 1: Physique S1. quantitative PCR for gene expression in broilers. Table S5. Primers used in the complete real-time quantitative PCR for caecal bacteria in broilers. Table S6. The effect of Api-PR19 on villus height, crypt depth and villus height/crypt depth ratio in the duodenum, jejunum, and ileum of broiler chickens. 40104_2020_462_MOESM1_ESM.docx (183K) GUID:?3D74BE9B-774C-4920-8E3B-AD39D489A67A Data Availability StatementThe sequence data were deposited and are available in the Sequence Read Archive (SRA) of NCBI under accession project number PRJNA578221. The sequence data were deposited and are available in the Sequence Browse Archive (SRA) of NCBI under accession task amount PRJNA578221. Abstract History Antibiotic development promoters (AGPs) have already been utilized as development promoters to keep animal intestinal health insurance and improve give food to performance in broilers by inhibiting pathogen proliferation. Because from the developing ...
These topics assume that Analysis Services is installed on a member server in a domain, instead of on a domain controller or on a stand-alone computer. Installing Analysis Services on a domain controller is not recommended for performance and security reasons. For more information about how to help secure the Windows operating system, see the Microsoft Security Web site. ...
Hand-sewing sequins can be tedious work, but doing so can create a fabulous finish for a piece. Sequins can add a great amount of pizazz to a simple garment, though they are also somewhat gentle and prone to falling off. Knowing how to hand-sew sequins can save you some money, and will also help you repair a dress when its sequins fall off.. ...
ENA captures, preserves and presents the worlds nucleotide sequence data. New content is included in ENA on a continuous basis and are distributed daily from our browser and RESTful service. The ENA assembled/annotated sequence release provides a quarterly snapshot of content in this important subset of ENA content.. As announced previously we have now stopped including cross referencing (XREF) information in released flat files. Due to the periodic release cycle and limitations of the format, the XREF lines contained in flat files could not be up to date. Up to date XREF information can only be available from the XREF API (https://www.ebi.ac.uk/ena/browse/xref-service-rest) and against records in the web browser, with further enhancements to this service with the release of the new ENA browser later this year. These services are updated on a daily basis and will contain the latest XREF information.. ...
IARC submission currently follows a INSDC first approach, means that all sequence data related to the reported inference is REQUIRED to be properly deposited in a general purpose sequence repository before it is reviewed by IARC. The submitter needs to complete the initial steps of submission to one of the INSDC repositories. Upon submission to IARC, some of this data will be pulled in from NCBI (TODO: What kind of data can we actually pull down from INSDC?). The aim of this procedure is to ensure that inferences reviewed by IARC are public and will remain available in the long run. It is however explicitly not the aim to provide data that deterministically will yield the same inference results.. ...
Copyright 2007-2009 by Peter Cock. All rights reserved. # This code is part of the Biopython distribution and governed by its # license. Please see the LICENSE file that should have been included # as part of this package. # # This code is NOT intended for direct use. It provides a basic scanner # (for use with a event consumer such as Bio.GenBank._FeatureConsumer) # to parse a GenBank or EMBL file (with their shared INSDC feature table). # # It is used by Bio.GenBank to parse GenBank files # It is also used by Bio.SeqIO to parse GenBank and EMBL files # # Feature Table Documentation: # http://www.insdc.org/files/feature_table.html # http://www.ncbi.nlm.nih.gov/projects/collab/FT/index.html # ftp://ftp.ncbi.nih.gov/genbank/docs/ # # 17-MAR-2009: added wgs, wgs_scafld for GenBank whole genome shotgun master records. # These are GenBank files that summarize the content of a project, and provide lists of # scaffold and contig files in the project. These will be in annotations[wgs] and # ...
For each backup file, the user who runs the restore command must have permission to read from the backup location specified for each file. To restore an Analysis Services database that is not installed on the server, the user must also be a member of the server role for that Analysis Services instance. To overwrite an Analysis Services database, the user must have one of the following roles: a member of the server role for the Analysis Services instance, or a member of a database role with Full Control (Administrator) permissions on the database to be restored. ...
Use this page to investigate EPDnew promoters for their chromatin status or motifs enrichment/distribution with our tools. If you want to restrict the analysis to a subset of promoters please use the promoter selection tool page. ...
For details please write to us at genomicsatgenotypic.co.in. Hybrid Assembly Services. Genotypic also offers Hybrid Assembly Analysis Service, which allows clients to validate their NGS data from different platforms (Roche 454, PacBio, Illumina, SOLiD, Ion Torrent, Ion Proton) to close gaps ...
Unique Identity Scheme will take away the Privacy of Indian Citizens -Mathew Thomas. Aadhaar is Built on a Platform of Myths - R. RamaKumar. UID Project Will Make Constitution Of India A Dead Document - S.G.Vombatkere. Aadhaar will institutionalsie Poverty - Ram Krishnaswamy. If our Government is selling the Country, then we should know at least who they are selling it to- Veeresh Malik. UID is a Unique Indian Donkey that will collapse under the load - Ram Krishnaswamy. The UID is a corporate scam which funnels billions of dollars into the IT sector - Arundhati Roy. Aadhaar is bound to fail - Aruna Roy. Aadhaar - Uidais unsolicited Testimonials to the Biometric Industry -David Moss, UK. It is a Bad Idea to Marry UID with NREGA -Reetika Khera. The Reserve Bank says Aadhaar is not good enough to open a bank account. You can Beat the UID reader with candle wax and Fevicol - J.T.D Souza. ...
The core facility Microarray Analysis Service (SAM) from IMIM (Hospital del Mar Medical Research Institute), using the Affymetrix GeneChip® platform, offers an integrated service for expression, cytogenetic and genomic studies needed by both public and private organizations. SAM scientific and technical core facility provides support to researchers for any task, from basic research to clinical diagnosis. The experimental services offered are the sample quality, quantification and microarray process. Experimental design consultancy, statistical data analysis and orientation to its biological interpretation with specific tools are also included. ...
This specific write-up is going to provide you all of the info you need concerning CMV an infection. Medication utilizes the word hapacol.vn/chu-de/paracetamol disease for this specific illness also its recognized to remain by having the Herpes family unit of viruses. The disease is believed to distribute subsequent to good communication becoming the individual transporting the multitude and also the […]. ...
As a Dhinam Oru Kural subscriber, you receive daily updates regarding content, meaning, Avvai Tamil Sangam updates and services we offer to our subscribers. If you do not wish to receive e-mails like this one, click here to UNSUBSCRIBE or send email to [email protected] with subject UNSUBSCRIBE ...
SQL Server 2012 Analysis Services introduces an impressive array of improvements designed to expand the reach a broader user base. SSAS brings together the existing multi-dimensional model with the
Clients communicate with Analysis Services using the public standard XML for Analysis (XMLA), a SOAP-based protocol for issuing commands and receiving responses, exposed as a Web service. Client object models are also provided over XMLA, and can be accessed either by using a managed provider, such as ADOMD.NET, or a native OLE DB provider ...
6. The thing that is the most striking to me is that we are about to make a 20 year choice, yet youre hedging on your favorite pick based on current valuation. It will take a significant period of time given the $100/mo budgeted for this portfolio to build up a meaningful position. Why not go with your gut and your number one choice. After reading your own analysis Pfizer appears to be the gold standard. While all four companies represent great long-term growth opportunity, Pfizer is the one best suited to meet the original criteria you set forth before we started down this road. Buy the best and the valuation will take care of itself! IMHO I think you want Pfizer. No matter what happens, that is the direction I am headed. 7. After reading through your writings, I have decided to go with Schering-Plough. Their profit margin is better and when its all boiled down, I think thats one of the most important things to look at. I dont disagree with your writings, but were hoping SGP looks better ...
Regarding Bidens miserable Town Hall counter presentations:. Who is deliberately sabotaging Biden with the production of such amateurish high school quality productions/presentations? Inquiring minds want to know.. The guy posting himself shopping in Walmart trying to infect everyone with the China Virus has better production values… Clearly someone in the Democratic Machine is doing their best to intercourse up the presumptive nominees campaign. Does anyone think the One or Walking Eagle would have put up with this even once? Heads would have rolled. I remember Walking Eagle raised all kinds of hell with all kinds of cussing when her handlers once allowed a reporter to ask a modestly difficult question during a live appearance.. These - unlike Trumps long live press conferences - are not open live events in that they can be orchestrated to the nth degree before being released. Dont they even rehearse their message? Doesnt Gaff O. Joe even practice? Cant his staff make sure the ...
Check daily for the latest case, death and hospitalization data in Larimer County and across Colorado as of March 1, including cases reported by CSU.
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New York, New York (Vocus) September 25, 2009 -- The Crohns & Colitis Foundation today announced the launch of its DNA Data Bank, a newly created resource
As a member of the Group Finance Solvency II team, you will be supporting the SII quantitative reporting manager in preparing analysis on economic movements of the period, deviation analysis between actual, forcast or landing and plan information for SCOR Group as well as the 5 solo entities, SCOR SE, SCOR Global Life SE, SCOR Global P&C SE, SCOR UK Ltd. and SCOR Global Life Reinsurance Ireland dac. Such analysis processes and tools shall be further developped based on the needs of the company.
In the upcoming releases, we are expecting to provide more data for a multitude of prokaryotic and eukaryotic pathways for more RNA classes. We are looking for contributors, who would like to help us with supplementing data! MODOMICS and RNApathwaysDB are two complementary resources whichpresent RNA metabolism at different levels. While MODOMICS presents RNA modification pathways on the level of nucleosides, RNApathwaysDB deals with RNA metabolism with respect to whole RNA molecules. Our ultimate goal is to integrate these databases, however at the moment the users are invited to consult both of these complementary resources, depending on their needs and interests. ...
Adding an assay to a publication can be done on the My publication page (see Q8). On this page you can select a publication from th dropdown list to view all its assays. All the assays which have not been orgnanized in other publication-subgroups yet, can be found under All the assays of this publication. To add additional assays to a publication click on the Add assay link next to the All the assays of this publication header, select the desired assays using the checkboxes on the next page and click on Add assay(s). In a publication extra subgroups can be greated to organize the assays, a subgroup Reference is automatically generated when creating a publication (The Reference subgroup can be used to group all the assays of the publication which have been used as reference-assays/reference genes. The assays in this subgroup will be visualized when querying for reference-assays in the Search or Browse page). New subgroups can be created by clicking on Create a new group. Assays can be assigned or ...
SCOR Global Life US (SGLUS), a wholly-owned subsidiary of the SCOR Group, has completed the acquisition of 100% of the capital stock of XL Re Life America Inc. (XLRLA) from XL Capital Ltd. The transaction was originally announced on July 22, 2009. The acquisition helps SCOR Global Life strengthen its services in the mortality-protection field and reinforce its position in the United States. This acquisition also demonstrates the inroads SCOR is making in the most important Life market in the world.
book, ... ,book-front,...,/book-front, ,body, ,book-part id=bid.1 book-part-type=part book-part-number=Part 1, ,book-part-meta,...,/book-part-meta, ,body, ,book-part id=bid.2 book-part-type=chapter book-part-number=1, ,book-part-meta, ,title-group, ,title,GenBank: The Nucleotide Sequence Database,/title, ,/title-group,... ,abstract, ,title,Summary,/title, ,p,The GenBank sequence database is an annotated collection ...,/p, ... ,/abstract, ,/book-part-meta, ,body, ,sec id=bid.3, ,title,History,/title, ,p,Initially, GenBank was built and maintained at Los Alamos National Laboratory ...,/p, ,/sec, ... ,/body, ... ,/book-part, ... ,/body, ,/book-part, ... ,/body, ... ,/book ...
We used a comprehensive collection of Affymetrix microarray datasets to ascertain which genes or molecules distinguish the known major subsets of huma
This is to kindly invite you to submit abstracts for the AFREhealth Symposium and D43 Grantees meeting due 5-8 August 2018 in South Africa. Abstract submissions are via the website website www.afrehealth.org and closing date is 30th May 2018. See details below. Abstract Submissions and workshop proposals open: 9 February 2018 Closing date for Abstract submissions and workshop proposals: 30 May 2018 Please note the following: ┬À Acknowledgement of receipt will be sent within 3 days
The aim of Symposium on Bioinformatics and Bioforensics (SBB18) is to provide a platform for researchers, engineers, academicians as well as industrial professionals to present their research results and development activities in bioinformatics and bioforensics. SBB18 invites original and unpublished work from individuals active in the broad theme of the symposium. Authors should submit their papers online using EDAS. Unregistered authors should first create an account in EDAS to log on. Further guidelines for submission are posted at: http://icacci-conference.org/2018/content/paper-submission-guidelines . The program committee solicits previously unpublished papers offering novel research contributions in any aspect of bioinformatics and bioforensics.. ...
DBTSS use - posted in DNA Methylation and Epigenetics: Hello Can some one help how to read a search results of the DBTSS!? I need to know where exactly the TSS location on the results. Also, if I find many TSS sites which one I should choose for designing primers for H3K4mee by ChIP-qPCR? Thanks Epigenome
Brief announcements of national and international conferences; also calls for papers and advanced notice. The submitted URL should lead directly to more detailed information, including registration fees. If you do not have a web site, look for someone to lend you a page. Conferences will normally be placed here in order of the opening dates, and removed after the conference has started. Please re-submit for next years conference, even if the URL is the same - this helps us to be sure we are up-to-date. Any suggestions - and all submissions - are welcome
Vape Bargains is a community-based website where members can share the best UK Vaping Deals, Discounts and Coupons. Get the lowest UK prices for E-liquid, Vape Box Mods & E-Cigarette Starter Kits. Dont miss out on flash sales, discount coupon codes and exclusive deals on Vaping Tanks, Mech Mods, and more!. Find the best prices, submitted and voted on by vapers themselves for all of these categories and more such as RDA / RDTAs, 18650 and 20700 batteries, Coils / Atomizers & more.. Vape Bargains UK is strictly for over 18s only. All products and deals listed on the website are their respected owners responsibility. Were a comparison site, and therefore cannot be held responsible for the actions of other companies mentioned on this website.. All submissions are voted on by vapers so you know that the top UK deals are worth taking note of. Throughout 2021, you will get the cheapest prices and we will tell you everywhere that is having a Clearance Sale in 2021.. ...
Photography 101 submission for Wednesday, November 5th. I havent had a chance to go out with the camera this week. I know these submissions are supposed to be new, but with school and the family I simply have not had the time. This photo hasnt been posted as of yet. I took it about a month…
This form is for the sole use of vacationers interested in making an inquiry for a stay at this property. All submissions are monitored for quality assurance. Use of this form for the purpose of solicitation is strictly prohibited and offenders will be blocked from the VRconnection Web site and reported to their respective service providers. Clicking the Send Inquiry button will indicate that you understand and agree to these terms ...
This form is for the sole use of vacationers interested in making an inquiry for a stay at this property. All submissions are monitored for quality assurance. Use of this form for the purpose of solicitation is strictly prohibited and offenders will be blocked from the VRconnection Web site and reported to their respective service providers. Clicking the Send Inquiry button will indicate that you understand and agree to these terms ...
The major focus of Behaviour Research and Therapy is an experimental psychopathology approach to understanding emotional and behavioral disorders and their prevention and treatment, using cognitive, behavioral, and psychophysiological (including neural) methods and models. This includes laboratory-based experimental studies with healthy, at risk and subclinical individuals that inform clinical application as well as studies with clinically severe samples. The following types of submissions are encouraged: theoretical reviews of mechanisms that contribute to psychopathology and that offer new treatment targets; tests of novel, mechanistically focused psychological interventions, especially ones that include theory-driven or experimentally-derived predictors, moderators and mediators; and innovations in dissemination and implementation of evidence-based practices into clinical practice in psychology and associated fields, especially those that target underlying mechanisms or focus on novel ...
Atlanta, GA (PRWEB) February 03, 2016 -- Submissions are being accepted now for Professional Photographers of Americas (PPA) District Level Photographic
The first month of 2020 has come and gone ... If our #InRotation submissions are any indication ... this decade is going to be full of incredible music. We asked our Morning AMP Host, the illustrious Jill Hopkins, to pick her 5 favorite tracks from our #InRotation chart for January.
Obtaining the COVID-19 passport is closer and easier than ever, within reach of companies, organisations and individuals. A new extraction point to offer COVID-19 analytical services has opened its doors on Monday 19th July in Building 101 of the Bizkaia Science and Technology Park, thanks to DNA Data and BIOLAN Health. A wide range of…
Primary databases[edit]. *Crystallography Open Database (COD). *Protein Data Bank (PDB). *Nucleic Acid Databank (NDB) ... 1999). Crystallization of Nucleic Acids and Proteins: A Practical Approach (2nd ed.). Oxford: Oxford University Press. ISBN 0- ... "For their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in ... "For their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in ...
Nucleic Acids Research. 40 (20): e159. doi:10.1093/nar/gks709. PMC 3488212. PMID 22844100.. CS1 maint: Multiple names: authors ... various deduplication and difference-coding techniques are applied that help decorrelate data and describe new data based on ...
"Nucleic Acids Research. 45 (3): 1059-1068. doi:10.1093/nar/gkw1182. PMC 5388404. PMID 28180287.. ... Prokaryotic AARS database: Chaliotis et al., (2017). The complex evolutionary history of aminoacyl-tRNA synthetases. Nucleic ... This expands the genetic code, beyond the twenty canonical amino acids found in nature, to include an unnatural amino acid as ... the cavity that holds the amino acid can be mutated and modified to carry unnatural amino acids synthesized in the lab, and to ...
"Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.. ... acid-amino acid ligase activity. • NEDD8 activating enzyme activity. • ubiquitin-like modifier activating enzyme activity. • ...
"Cytochrome P450 database". Nucleic Acids Research.. *. Degtyarenko K (2009-01-09). "Directory of P450-containing Systems" ... eicosapentaenoic acid (i.e. EPA) to epoxyeicosatetraenoic acids (i.e. EEQs); and docosahexaenoic acid (i.e. DHA) to ... arachidonic acid or fatty acid metabolism. 6 subfamilies, 12 genes, 10 pseudogenes. CYP4A11, CYP4A22, CYP4B1, CYP4F2, CYP4F3, ... CYP4F22 ω-hydroxylates extremely long "very long chain fatty acids", i.e. fatty acids that are 28 or more carbons long. The ω- ...
"Nucleic Acids Research. 39 (Database issue): D58-65. doi:10.1093/nar/gkq1063. PMC 3013671. PMID 21062818.. ... "Database. 2011: baq036. doi:10.1093/database/baq036. PMC 3025693. PMID 21245076.. *^ Fontaine JF, Barbosa-Silva A, Schaefer M, ... "Nucleic Acids Research. 37 (Web Server issue): W141-6. doi:10.1093/nar/gkp353. PMC 2703945. PMID 19429696.. ... "Nucleic Acids Research. 32 (Web Server issue): W16-9. doi:10.1093/nar/gkh453. PMC 441591. PMID 15215341.. ...
"Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.. ... glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters *SLC7A5 ...
"Nucleic Acids Res. 38 (Database issue): D227-33. doi:10.1093/nar/gkp971. PMC 2808883. PMID 19892822.. ... An up-to-date classification of protease evolutionary superfamilies is found in the MEROPS database.[4] In this database, ... TopFIND - database of protease specificity, substrates, products and inhibitors. *MEROPS - Database of protease evolutionary ... aspartic acid, metallo- and acid proteases) nucleophilic so that it can attack the peptide carboxyl group. One way to make a ...
Nucleic Acids Research. 40 (20): e159. doi:10.1093/nar/gks709. PMC 3488212. PMID 22844100.. ... various deduplication and difference-coding techniques are applied that help decorrelate data and describe new data based on ...
"Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.. ... "Nucleic Acids Res. 34 (21): 6126-36. doi:10.1093/nar/gkl875. PMC 1693901. PMID 17085477.. ... nucleic acid binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ...
2013). "StreptomeDB: a resource for natural compounds isolated from Streptomyces species". Nucleic Acids Res. 41 (Database ... Nucleic Acids Research. 15 (19): 8041-56. doi:10.1093/nar/15.19.8041. PMC 306325 . PMID 3118332. Dr. Mark Nelson; Robert A. ... E. coli is well understood and has a successful track record producing insulin, the artemisinin precursor artemisinic acid, and ... Clavulanic acid (Streptomyces clavuligerus) is used in combination with some antibiotics (like amoxicillin) to weaken bacterial ...
Inorganic Crystal Structure Database. *Inspec. *Medline. *Metals Abstracts/METADEX. *Nucleic Acid Database ...
"Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.. ...
"Nucleic Acids Res. 40 (Database issue): D834-40. doi:10.1093/nar/gkr997. PMC 3245142. PMID 22102591.. Hopf TA, Schaerfe CP, ... "Nucleic Acids Res. 37 (Database issue): D661-8. doi:10.1093/nar/gkn794. PMC 2686459. PMID 18984613.. ... "Nucleic Acids Research. 44 (W1): W529-35. doi:10.1093/nar/gkw363. ISSN 0305-1048. PMC 4987915. PMID 27131791.. ... "Nucleic Acids Research. 37 (Web Server issue): W519-W525. doi:10.1093/nar/gkp306. PMC 2703994. PMID 19420059.. ...
"The Database of Interacting Proteins: 2004 update". Nucleic Acids Research. 32 (90001): D449-D451. doi:10.1093/nar/gkh086. PMC ... His research group hosts the Database of Interacting Proteins.[16] Career[edit]. *Postdoctoral research, Princeton University ( ... David Eisenberg's publications indexed by the Scopus bibliographic database. (subscription required) *^ Eisenberg, David J. ( ...
"Nucleic Acids Research. 39 (Database): D19-D21. doi:10.1093/nar/gkq1019. ISSN 0305-1048. PMC 3013647. PMID 21062823.. ... Database management[edit]. Each relational database system has its own mechanisms for storing metadata. Examples of relational- ... though they may be submitted to biomedical databases after publication. The original authors and database curators then become ... In database terminology, this set of metadata is referred to as the catalog. The SQL standard specifies a uniform means to ...
"5S Ribosomal RNA Database". Nucleic Acids Res. 30 (1): 176-8. doi:10.1093/nar/30.1.176. PMC 99124. PMID 11752286.. .mw-parser- ... "Nucleic Acids Research. 27 (2): 637-42. doi:10.1093/nar/27.2.637. PMC 148226. PMID 9862991.. ... "Nucleic Acids Res. 42 (22): 13764-13777. doi:10.1093/nar/gku1266. PMC 4267664. PMID 25429974.. ... DiNitto, JP; Huber, PW (Oct 23, 2001). "A role for aromatic amino acids in the binding of Xenopus ribosomal protein L5 to 5S ...
Zwieb C (January 1997). "The uRNA database". Nucleic Acids Research. 25 (1): 102-3. doi:10.1093/nar/25.1.102. PMC 146409. PMID ... Thomas J, Lea K, Zucker-Aprison E, Blumenthal T (May 1990). "The spliceosomal snRNAs of Caenorhabditis elegans". Nucleic Acids ...
H. Berman et al.: The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data. In: Nucleic Acids ... Database: the journal of biological databases and curation. Band 2011, 2011, S. bar003, doi:10.1093/database/bar003, PMID ... H.M. Berman et al.: The Protein Data Bank. In: Nucleic Acids Res. Bd. 28, 2000, S. 235-242. ... Nucleic Acids Res.. . 28, Nr. 1, January 2000, S. 235-242. doi:10.1093/nar/28.1.235. PMID 10592235. PMC 102472 (freier Volltext ...
"Nucleic Acids Res. 43 (Database issue): D789-98. doi:10.1093/nar/gku1205. PMC 4383985 . PMID 25428349.. ... Comparative Toxicogenomics Database, a database that integrates chemicals and genes with human diseases, including OMIM data. ... MARRVEL, a website that uses OMIM as one of the six human genetic databases and seven model organism databases to integrate ... The database may be used as a resource for locating literature relevant to inherited conditions,[7] and its numbering system is ...
"The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID ...
"T3DB: a comprehensively annotated database of common toxins and their targets". Nucleic Acids Res. 38 (Database issue): D781-6 ... "Nucleic Acids Res. 37 (Database issue): D603-10. January 2009. doi:10.1093/nar/gkn810. PMC 2686599. PMID 18953024.. ... It is also used by the Human Metabolome Database (HMDB)[18] and the Toxin and Toxin-Target Database (T3DB).[19] ... CrateDB - open source, distributed SQL database built on Lucene [13]. *DocFetcher - a multiplatform desktop search application[ ...
"Nucleic Acids Research. 36 (Database issue): D440-4. doi:10.1093/nar/gkm883. PMC 2238979. PMID 17984083.. ... Other databases: Protein Data Bank, Ensembl and InterPro. *Specialised genomic databases: BOLD, Saccharomyces Genome Database, ... "Nucleic Acids Research. 36 (Web Server issue): W368-71. doi:10.1093/nar/gkn256. PMC 2447766. PMID 18480123.. ... "Nucleic Acids Research. 36 (10): 3420-35. doi:10.1093/nar/gkn176. PMC 2425479. PMID 18445632.. ...
"Saccharomyces Genome Database: the genomics resource of budding yeast". Nucleic Acids Research. 40 (Database issue): D700-5. ... This is mainly because these species can grow in the presence of high sucrose, ethanol, acetic acid, sorbic acid, benzoic acid ... Nucleic Acids Research. doi:10.1093/nar/gky961. PMID 30321395.. *^ Siddiqui MS, Thodey K, Trenchard I, Smolke CD (2012). " ... They are often used in the same way that monosodium glutamate (MSG) is used and, like MSG, often contain free glutamic acid.[96 ...
"Nucleic Acids Res. England. 39 (Database issue): D822-9. doi:10.1093/nar/gkq1077. PMC 3013679. PMID 21036866.. ... Other databases: Protein Data Bank, Ensembl and InterPro. *Specialised genomic databases: BOLD, Saccharomyces Genome Database, ... Secondary databases: UniProt, database of protein sequences grouping together Swiss-Prot, TrEMBL and Protein Information ... Databases. *Sequence databases: GenBank, European Nucleotide Archive and DNA Data Bank of Japan ...
... new summaries and analyses of the known 3D structures of proteins and nucleic acids". Nucleic Acids Research. 33 (Database ... "Nucleic Acids Research. 37 (Database issue): D355-9. doi:10.1093/nar/gkn860. PMC 2686501. PMID 18996896.. ... "Nucleic Acids Research. 42 (Database issue): D292-6. doi:10.1093/nar/gkt940. PMC 3965036. PMID 24153109.. ... "Nucleic Acids Research. 39 (Database issue): D1035-41. doi:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.. ...
"Nucleic Acids Research. 38 (Database issue): D190-5. doi:10.1093/nar/gkp951. PMC 2808932. PMID 19900971.. ... "Nucleic Acids Research. 36 (Database issue): D991-8. doi:10.1093/nar/gkm934. PMC 2238940. PMID 17986457.. ... "Nucleic Acids Research. 38 (Database issue): D196-203. doi:10.1093/nar/gkp931. PMC 2808972. PMID 19892828.. ... "Nucleic Acids Research. 34 (Database issue): D363-8. doi:10.1093/nar/gkj123. PMC 1347485. PMID 16381887.. ...
"Nucleic Acids Research. 36 (Database issue): D572-D576. doi:10.1093/nar/gkm858. PMC 2238852. PMID 17942425.. ... PHI-base: a database of multiple pathogen-host interactions.[7]. GM protest[edit]. In 2012 Rothamsted started testing ... "Biographical Database of the British Chemical Community, 1880-1970". The Open University. Retrieved 29 August 2012.. ... Some of the chemists associated with Rothamsted can be found by searching on Rothamsted on the Biographical Database of the ...
... expanding the reference database for functional long noncoding RNAs". Nucleic Acids Research. 43 (Database issue): D168-173. ... a Wiki-based database of plant lncRNAs". Nucleic Acids Research. 44 (D1): D1161-D1166. doi:10.1093/nar/gkv1215. ISSN 0305-1048 ... Nucleic Acids Research. 39 (Database issue): D146-D151. doi:10.1093/nar/gkq1138. PMC 3013714 . PMID 21112873. Quek, Xiu Cheng; ... Nucleic Acids Research. 43 (Database issue): 187-192. doi:10.1093/nar/gku1167. PMID 25399417. Smith, JE; Alvarez-Dominguez, JR ...
"Nucleic Acids Research. 40 (Database issue): D700-5. doi:10.1093/nar/gkr1029. PMC 3245034. PMID 22110037.. ... This is mainly because these species can grow in the presence of high sucrose, ethanol, acetic acid, sorbic acid, benzoic acid ... "Nucleic Acids Research. 47 (D1): D821-D827. doi:10.1093/nar/gky961. PMC 6324063. PMID 30321395.. ... "Saccharomyces Genome Database.. *^ Cherry, JM; Hong, EL; Amundsen, C; Balakrishnan, R; Binkley, G; Chan, ET; Christie, KR; ...
Nucleic Acids Res. November 2002, 30 (21): 4634-42. PMC 135794. PMID 12409453. doi:10.1093/nar/gkf587.. ... a 50-amino acid deletion in prelamin A (amino acids 607-656) removes the site for the second endoproteolytic cleavage. ...
2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. PMID ...
2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. PMID ... "Nucleic Acids Res. 39 (Database issue): D1035-41. PMC 3013709. PMID 21059682. doi:10.1093/nar/gkq1126. ... "Nucleic acids research 36 (Database issue): D901-6. PMC 2238889. PMID 18048412. doi:10.1093/nar/gkm958. ...
... nucleic acid constituents, carbohydrates and ionophore complexes.[218]. Lithium naturally only occurs in traces in biological ... "The Internet Database of Periodic Tables". meta-synthesis.com. Retrieved 6 April 2012 ... Sodium salts of fatty acids are used as soap.[197] Pure sodium metal also has many applications, including use in sodium-vapour ... Indeed, transferring of protons between chemicals is the basis of acid-base chemistry.[10]:43 Also unique is hydrogen's ability ...
2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. PMID ... Oleic acid, Chemical Laboratory Information Profile, American Chemical Society *↑ 3,0 3,1 Alfred Thomas (2002). "Fats and Fatty ... "Fatty acid composition of human adipose tissue from two anatomical sites in a biracial community". American Journal of ... "The inheritance of high oleic acid in peanut". http://jhered.oxfordjournals.org/cgi/pdf_extract/80/3/252. ...
"Nucleic Acids Research. 41 (Database issue): D36-D42. doi:10.1093/nar/gks1195. PMC 3531190. PMID 23193287.. ... "Nucleic Acids Res. 39 (Database issue): D32-37. doi:10.1093/nar/gkq1079. PMC 3013681. PMID 21071399.. ... "Nucleic Acids Research. 36 (Database): D25-D30. doi:10.1093/nar/gkm929. PMC 2238942. PMID 18073190.. ... "Nucleic Acids Research. 37 (Database): D26-D31. doi:10.1093/nar/gkn723. PMC 2686462. PMID 18940867.. ...
"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs". Nucleic Acids Research 25 (17). Págs. 3389- ... "Nucleic Acids Research 22 (17).. *↑ Un bo recurso de introdución a EMBnet é a páxina What is EMBnet? Arquivado 07 de setembro ... "Nucleic Acids Research 4 (11). Páxs. 4037-4051.. *↑ 33,0 33,1 Sanger, F.; et al. (1978). "The nucleotide sequence of ... "Nucleic Acids Research 22 (22). Páxs. 4673-80.. *↑ Altschul, S. F.; et al. (1997). ...
"Nucleic Acids Res. 37 (Database issue): D274-8. doi:10.1093/nar/gkn862. PMC 2686586. PMID 19022853.. ... Classification of transporters can be found in Transporter Classification Database.[5]. As an example of the relationship ... Homology modeling can be used to construct an atomic-resolution model of the "target" integral protein from its amino acid ... is embedded in the hydrophobic regions of the bilayer are alpha helical and composed of predominantly hydrophobic amino acids. ...
"Nucleic Acids Res. 38 (Database issue): D557-62. January 2010. doi:10.1093/nar/gkp972. PMC 2808936. PMID 19906699. http://www. ... "Nucleic Acids Res 39 (Database issue): D800-D806. November 2010. doi:10.1093/nar/gkq1064. PMC 3013672. PMID 21045057. http:// ...
"Nucleic Acids Research. 34 (9): 2653-62. doi:10.1093/nar/gkl338. PMC 1464108. PMID 16714444.. ... HistoneDB 2.0 - Database of histones and variants at NCBI. *Chromatin, Histones & Cathepsin; PMAP The Proteolysis Map-animation ... The single-letter amino acid abbreviation (e.g., K for Lysine) and the amino acid position in the protein ... compared amino acid compositions in the same histone from different organisms, and compared amino acid sequences of the same ...
"Nucleic Acids Res. 39 (Database issue): D1035-41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.. ... "Nucleic acids research. 36 (Database issue): D901-6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.. ...
"Nucleic Acids Res. 39 (Database issue): D1035-41. PMC 3013709. PMID 21059682. doi:10.1093/nar/gkq1126. edit ... "Nucleic acids research 36 (Database issue): D901-6. PMC 2238889. PMID 18048412. doi:10.1093/nar/gkm958. edit ...
1993) The ribosomal database project. Nucleic Acids Res. Jul 1;21(13):3021-3. ... "Nucleic Acids Research 12 (14): 5837-52. PMC 320035. PMID 6462918. doi:10.1093/nar/12.14.5837.. ... "Nucleic Acids Research 24 (17): 3381-91. PMC 146102. PMID 8811093. doi:10.1093/nar/24.17.3381.. ... "Nucleic Acids Research 38 (22): e203. PMC 3001097. PMID 20923781. doi:10.1093/nar/gkq865.. ...
Analysis of nucleic acids structures[edit]. Psoralens can reversibly crosslink nucleic acids double helices, and therefore have ... Duke's Phytochemical and Ethnobotanical Databases". U.S. Department of Agriculture, Agricultural Research Service. Retrieved ... Cimino GD, Gamper HB, Isaacs ST, Hearst JE (1985). "Psoralens as Photoactive Probes of Nucleic Acid Structure and Function: ... such as ring opening by alkali to give a coumarinic acid or coumaric acid derivative. Potassium permanganate causes oxidation ...
... be transferred from nucleic acid to nucleic acid but cannot be transferred back from protein to either protein or nucleic acid ... The Cochrane Database of Systematic Reviews (4): CD002037. doi:10.1002/14651858.CD002037. ISSN 1469-493X. PMID 14583945.. ... Ribosome units are used to transcribe the mRNA of the virus into the amino acid sequences which can be made into proteins in ...
Watson, J. D.; Crick, FH (1953). "Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid" (PDF). Nature ... "About the HGNC". HGNC Database of Human Gene Names. HUGO Gene Nomenclature Committee. Retrieved 14 May 2015. ... Hershey, AD; Chase, M (1952). "Independent functions of viral protein and nucleic acid in growth of bacteriophage". The Journal ... Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III". The Journal of ...
"Nucleic Acids Research. 42 (16): 10618-31. doi:10.1093/nar/gku734. PMC 4176335. PMID 25120263.. ... InnateDB, database of proteins and their interactions in innate immune system. *v ... Sweat, desquamation, flushing,[2] organic acids[2] Gastrointestinal tract. Peristalsis, gastric acid, bile acids, digestive ... such as salicylic acid or jasmonic acid. Some of these travel through the plant and signal other cells to produce defensive ...
"Nucleic Acids Research》 41 (Database issue): D764-72. doi:10.1093/nar/gks1049. PMC 3531171. PMID 23203881.. ... "Chymosin - GMO Database". 》GMO Compass》. European Union. 10 July 2010. 26 March 2015에 원본 문서에서 보존된 문서. 1 March 2015에 확인함.. ... "Protease - GMO Database". 》GMO Compass》. European Union. 10 July 2010. 24 February 2015에 원본 문서에서 보존된 문서. 28 February 2015에 확인함. ... Smith S (December 1994). "The animal fatty acid synthase: one gene, one polypeptide, seven enzymes". 》FASEB Journal》 8 (15): ...
Nucleic Acids Res. 40 (Database issue): D271-7. doi:10.1093/nar/gkr922. PMC 3245166. PMID 22053087. Negi SS, Braun W (2009). " ... Databases and computational tools for mimotopes have been an important part of phage display study. Databases, programs and web ... Nucleic Acids Res. 34 (21): e145. doi:10.1093/nar/gkl772. PMC 1693883. PMID 17088290. Lunder M, Bratkovic T, Urleb U, Kreft S, ... Nucleic Acids Res. 22 (25): 5761-2. doi:10.1093/nar/22.25.5761. PMC 310144. PMID 7838733. Fuh G, Sidhu SS (September 2000). " ...
Nucleic Acids Res. 38 (Suppl_1): D75-80. doi:10.1093/nar/gkp902. PMC 2808995. PMID 19880380. data v t e. ... UTRdb is a database of 5' and 3' untranslated sequences of eukaryotic mRNAs Five prime untranslated region Three prime ...
Pingoud A, Jeltsch A (September 2001). "Structure and function of type II restriction endonucleases". Nucleic Acids Res. 29 (18 ... Code used to identify the structure of a protein in the PDB database of protein structures. The 3D atomic structure of a ... Nucleic Acids Res. 31 (7): 1805-12. doi:10.1093/nar/gkg274. PMC 152790. PMID 12654995. Jeremy MB, John LT, Lubert S (2002). "3 ... that means that there were no registered isoschizomers in the databases on that date with a clearly defined cutting site. ...
Durbin, Richard (23 April 1998). Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids. Cambridge ... GENSCAN was shown to exactly predict exon location with 90% accuracy with 80% specificity compared to an annotated database. ... Nucleic Acids Research. 26 (2): 544-548. doi:10.1093/nar/26.2.544. PMC 147303. PMID 9421513. "Glimmer: Microbial Gene-Finding ...
A new generation of protein database search programs". Nucleic Acids Research. 25 (17): 3389-3402. doi:10.1093/nar/25.17.3389. ...
Some of these are believed to affect the shape of nucleic acids (see for example RNA self-splicing), but this is only sometimes ... An example of a PFM from the TRANSFAC database for the transcription factor AP-1: The first column specifies the position, the ... "Noncoding" sequences are not translated into proteins, and nucleic acids with such motifs need not deviate from the typical ... Biology portal Biomolecular structure Mammalian Motif Finder Multiple EM for Motif Elicitation Nucleic acid sequence Protein ...
Kozlowski, LP (26 October 2016). "Proteome-pI: proteome isoelectric point database". Nucleic Acids Research. 45 (D1): D1112- ... Amino acids are the main source of chemical energy for H. salinarum, particularly arginine and aspartate, though they are able ... Vreeland, H; Rosenzweig, W D; Lowenstein, T; Satterfield, C; Ventosa, A (December 2006). "Fatty acid and DNA analyses of ... to metabolize other amino acids, as well. H. salinarum have been reported to not be able to grow on sugars, and therefore need ...
... the sugar component of nucleic acids. Fats are catabolised by hydrolysis to free fatty acids and glycerol. The glycerol enters ... Databases Flow Chart of Metabolic Pathways at ExPASy IUBMB-Nicholson Metabolic Pathways Chart SuperCYP: Database for Drug- ... The two nucleic acids, DNA and RNA, are polymers of nucleotides. Each nucleotide is composed of a phosphate attached to a ... lack all amino acid synthesis and take their amino acids directly from their hosts. All amino acids are synthesized from ...
2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID ...
... that bind nucleic acids (NA) and provide users with sets of specific information in relation to... ... The nucleic acids and ligands database (NALD) is concerned with the identification of ligands (drugs) ... The nucleic acids and ligands database (NALD) is concerned with the identification of ligands (drugs) that bind nucleic acids ( ... Bioinformatics Database Data mining Data integration Nucleic acids Binding motifs Ligands Drugs Diseases ...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
... was created in 1999 as a means of amalgamating the major protein signature databases into one comprehensive resource. PROSITE, ... results are provided in a single format that rationalises the results that would be obtained by searching the member databases ... The InterPro database, 2003 brings increased coverage and new features. Nucleic Acids Res (2003) Cached. * ... interpro database nucleic acid re new feature single format sequence-based searching integrated documentation resource ...
Why we need to group these databases?, Why databases are created and shared?, Why some databases are no longer in the databases ... and dropped from it?, Organisation of databases and its major grouping: (Categories list), Evolution of NAR database, Prepared ... Nucleic Acids Research Database, Numbers available :, Criteria for selection into NAR databases, ... Nucleic Acids Research Database. by Yee Ling Chew 1. Numbers available :. 1.1. 1512 online databases sorted into 14 categories ...
Nucleic acid translation. The IUPAC-IUB Encoding for Nucleic Acids. Value. Symbol. Name. ... During a search of a nucleic acid database, Mascot uses the taxonomy of each entry to choose the correct genetic code. If no ... Taxonomy can also be defined at a database level, to handle species specific databases such as EST_human. ... Although Mascot could try to determine whether a database entry is mitochondrial by performing a keyword search of the FASTA ...
IntAct provides an open source database and toolkit for the storage, presentation and analysis of protein interactions. The web ... database issue d452-d455 open source molecular interaction database nucleic acid re protein interaction interaction net-works ... R.: IntAct: an open source molecular interaction database. Nucleic Acids Res., (2004) 32 Database issue D452-D455 Cached. * ... title = {R.: IntAct: an open source molecular interaction database. Nucleic Acids Res., (2004) 32 Database issue D452-D455},. ...
... a human RNA-seq-based gene and transcript co-expression database. Nucleic Acids Res ... The 2015 Nucleic Acids Research Database Issue and Molecular Biology Database Collection by Michael Y. Galperin, Daniel J. ... GeneFriends: a human RNA-seq-based gene and transcript co-expression database. Nucleic Acids Res (2015) by S van Dam, T Craig, ... The 2015 Nucleic Acids Research Database Issue contains 172 papers that include descriptions of 56 new molecular biology ...
... a new generation of protein database search programs. Nucleic Acids Res. ... Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. (1997) by Altschul SF, ... This protocol was applied to identify partners and assign quaternary structures of proteins found in the yeast database of ... It also finds many new clusters of protein sequences which were not classified by these databases. The hierarchical ...
Erratum: ADPriboDB: The database of ADP-ribosylated proteins (Nucleic acids research (2017) 45 D1 (D204-D209)). Nucleic Acids ... Erratum : ADPriboDB: The database of ADP-ribosylated proteins (Nucleic acids research (2017) 45 D1 (D204-D209)). In: Nucleic ... Erratum : ADPriboDB: The database of ADP-ribosylated proteins (Nucleic acids research (2017) 45 D1 (D204-D209)). / Vivelo, ... Erratum: ADPriboDB: The database of ADP-ribosylated proteins (Nucleic acids research (2017) 45 D1 (D204-D209)). ...
Search database. All Databases. Assembly. Biocollections. BioProject. BioSample. BioSystems. Books. ClinVar. Conserved Domains ... The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers.. Boulay JL1, Dennefeld C, Alberga ... we present evidence that the complementary DNA-deduced protein product of sna contains five copies of a nucleic acid-binding ...
The 2019 Nucleic Acids Research Molecular Biology Database Collection. Table 1. Descriptions of new online databases in the ... Table 2. Updated descriptions of databases most recently published elsewhere. Database URL Brief description ... Cucurbit Genomics Database http://cucurbitgenomics.org Genomics of the Cucurbitaceae family dbAMP http://csb.cse.yzu.edu.tw/ ... 2019 NAR Database issue. Database URL Brief description AleDB http://aledb.org Mutations from Adaptive Laboratory Evolution ...
Computer Analysis of Protein and Nucleic Acid Sequences, Volume 183 - 1st Edition. Print Book & E-Book. ISBN 9780121820848, ... R.F. Doolittle, Searching through Sequence Databases.. S. Henikoff, J.C. Wallace, and J.P. Brown, Finding Protein Similarities ... J.C.W. Shepherd, Ancient Patterns in Nucleic Acid Sequences.. R. Staden, Searching for Patterns in Protein and Nucleic Acid ... Molecular Evolution: Computer Analysis of Protein and Nucleic Acid Sequences, Volume 183 1st Edition. 0.0 star rating Write a ...
The 2018 Nucleic Acids Research database issue features several papers from NCBI staff that cover the status and future of ... databases including CCDS, ClinVar, GenBank and RefSeq. These papers are also available on PubMed. To read an article, click on ... 5 NCBI articles in 2018 Nucleic Acids Research database issue. The 2018 Nucleic Acids Research database issue features several ... "5 NCBI articles in 2018 Nucleic Acids Research database issue" * Pingback: 5 NCBI articles in 2018 Nucleic Acids Research ...
Nucleic Acids Research Papers on IndiGenomes, DockCoV2, ViruSurf Databases. In Nucleic Acids Research this week: database to ... house IndiGen sequencing data, database of SARS-CoV-2 docking scores, and more. ...
Nucleic Acids Research Papers on IndiGenomes, DockCoV2, ViruSurf Databases. In Nucleic Acids Research this week: database to ... house IndiGen sequencing data, database of SARS-CoV-2 docking scores, and more. ...
RegulonDB is a reference database of Escherichia coli K-12. Transcriptional regulation is now part of a unit that initiates ... files for several relational database manager systems and text files including BioPAX format. ...
Zloh, M., Biekofsky, R. R., Duret, J. A., Danton, M. & Gibbons, W. A., 1995, In : Biomedical Peptides, Proteins & Nucleic Acids ... Biomedical Peptides, Proteins & Nucleic Acids : structure, synthesis & biological activity. ISSNs: 1353-8616 ... Nucleic Acids : structure, synthesis & biological activity. 1, 1, p. 31-8 8 p.. Research output: Contribution to journal › ...
"The 2012 Nucleic Acids Research Database Issue and the online Molecular Biology Database Collection". Nucleic Acids Res. 40 ( ... the wiki-database of biological databases". Nucleic Acids Res. 40 (Database issue): D1250-4. doi:10.1093/nar/gkr1099. PMC ... structure and functional databases. Nucleic acid and protein sequences are stored in sequence databases and structure databases ... Nucleic Acids Research Database IssueEdit. An important resource for finding biological databases is a special yearly issue of ...
Primary databases[edit]. *Crystallography Open Database (COD). *Protein Data Bank (PDB). *Nucleic Acid Databank (NDB) ... 1999). Crystallization of Nucleic Acids and Proteins: A Practical Approach (2nd ed.). Oxford: Oxford University Press. ISBN 0- ... "For their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in ... "For their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in ...
... practices and challenges of curating and making accessible biological information in databases. ... Bioinformatics and Biochemistry of Nucleic Acids. Module code: NT3005. This module will provide grounding regarding the ...
Focuses on cutting-edge research and applications to find and examine new approaches using nucleic acids in therapeutics ... ProQuest databases; SIIC Data Bases ... Nucleic Acid Therapeutics is the leading journal in its field ... The Journal examines many new approaches for using nucleic acids as therapeutic agents or in modifying nucleic acids for ... Nucleic Acid Therapeutics. • formerly Oligonucleotides. Co-Editors-in-Chief: Bruce A. Sullenger, PhD and Annemieke Aartsma-Rus ...
The genome Aggregation Database (gnomAD) population of 138,632 unrelated individuals was searched for previously identified ... ARVC variants, classified as pathogenic or unknown on the disease genetic variant database ( http://www.arvcdatabase.info/ ), ... Nucleic Acids Res. 2016;44:D862-8.. CAS Article Google Scholar *36.. Whiffin N, Minikel E, Walsh R, et al. Using high- ... analysis of the variant frequency in the largest available population database, summary of gene-specific database for each ...
The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases. Nucleic Acids Res ... Database resources of the national center for biotechnology information. Nucleic Acids Res. 37, D5-15 (2009). ... Taboada, B., Ciria, R., Martinez-Guerrero, C. E. & Merino, E. ProOpDB: Prokaryotic operon DataBase. Nucleic Acids Res. 40, D627 ... The Pfam protein families database: towards a more sustainable future. Nucleic Acids Res 44, D279-85 (2016). ...
"Nucleic Acids Research. 45 (3): 1059-1068. doi:10.1093/nar/gkw1182. PMC 5388404. PMID 28180287.. ... Prokaryotic AARS database: Chaliotis et al., (2017). The complex evolutionary history of aminoacyl-tRNA synthetases. Nucleic ... This expands the genetic code, beyond the twenty canonical amino acids found in nature, to include an unnatural amino acid as ... the cavity that holds the amino acid can be mutated and modified to carry unnatural amino acids synthesized in the lab, and to ...
A description is given of how the Nucleic Acid Database (NDB) is used to study nucleic acids. In addition, the way in which the ... nucleic acids and other biological macromolecules, with approximately 8000 entries, is described. ... Classifying a Protein in the CATH Database of Domain Structures. C. A. Orengo, A. M. Martin, G. Hutchinson, S. Jones, D. J. ... The CATH database of protein domain structures classifies structures according to their (C)lass, (A)rchitecture, (T)opology or ...
"MMDB and VAST+: tracking structural similarities between macromolecular complexes.Nucleic Acids Res. 2014 Jan; 42(Database ...
"MMDB and VAST+: tracking structural similarities between macromolecular complexes.Nucleic Acids Res. 2014 Jan; 42(Database ...
Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303. ...
PubChem substance and compound databases. Nucleic Acids Res. 44, D1202-D1213 (2016).. ... 4 was 2.11 μM and the Ki values were 62.5 μM and ,200 μM for 1-amino-2-naphthol and sulfanilic acid, respectively (Fig. 5D). ... We retrieved 22 additional reference genomes from the Integrated Microbial Genome Database (32) that belonged to six of the ... and the PubChem database (46). MayaChemTools software (47) was used to compute eight one-dimensional and two-dimensional ...
ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic Acids Res. 2012;40:D1100-7.CrossRefPubMedGoogle Scholar ... PubChem substance and compound databases. Nucleic Acids Res. 2016;44:D1202-13.CrossRefPubMedGoogle Scholar ... BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Nucleic Acids Res. 2007;35 ... The mutation operator provided an amino acid an equal chance of being substituted for any other amino acids within the defined ...
  • The 2018 Nucleic Acids Research database issue features several papers from NCBI staff that cover the status and future of databases including CCDS, ClinVar, GenBank and RefSeq. (nih.gov)
  • The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. (nih.gov)
  • GenBank is accessible through the NCBI Nucleotide database, which links to related information such as taxonomy, genomes, protein sequences and structures, and biomedical journal literature in PubMed. (nih.gov)
  • and searching the NCBI taxonomy database for correct inclusion of species information and taxonomic position. (nih.gov)
  • A search and retrieval system that integrates information from databases at NCBI. (tolweb.org)
  • al) from the Molecular Modeling Database (MMDB) at the NCBI. (scienceblogs.com)
  • BLAST keeps the position of each k-mer (k 11 by default) subsequence of the query in a hash table with the k-mer sequence being the key, and scans the database sequences for k-mer exact matches, called seeds, by looking up the hash table. (psu.edu)
  • J.C.W. Shepherd , Ancient Patterns in Nucleic Acid Sequences. (elsevier.com)
  • R. Staden , Searching for Patterns in Protein and Nucleic Acid Sequences. (elsevier.com)
  • P. Argos and M. Vingron , Sensitivity Comparison of Protein Amino Acid Sequences. (elsevier.com)
  • GenBank® is a comprehensive database that contains publicly available nucleotide sequences for 400 000 formally described species. (nih.gov)
  • [2] Information contained in biological databases includes gene function, structure, localization (both cellular and chromosomal), clinical effects of mutations as well as similarities of biological sequences and structures. (wikipedia.org)
  • Nucleic acid and protein sequences are stored in sequence databases and structure databases store solved structures of RNA and proteins. (wikipedia.org)
  • Repbase is a reference database of eukaryotic repetitive DNA, which includes prototypic sequences of repeats and basic information described in annotations. (nih.gov)
  • In press, Nucleic Acids Res] Yeats C, Lees J, Carter P, Sillitoe I, Orengo C "The Gene3D Web Services: a platform for identifying, annotating and comparing structural domains in protein sequences. (ebi.ac.uk)
  • M. lentiflavum is slow growing at 22°C-37°C and has yellow pigmentation, negative tests for Tween 80 hydrolysis, nicotinic acid, nitrate reductase and urease, distinct fatty and mycolic acid patterns, and unique 16S rRNA and 65-kDa heat-shock protein gene sequences. (cdc.gov)
  • Term] id: EDAM:0001234 name: Sequence set (nucleic acid) namespace: data def: Any collection of multiple nucleotide sequences and associated metadata that do not (typically) correspond to common sequence database records or database entries. (umanitoba.ca)
  • Term] id: EDAM:0000850 name: Sequence set namespace: data def: A collection of multiple molecular sequences and associated metadata that do not (typically) correspond to molecular sequence database records or entries and which (typically) are derived from some analytical method. (umanitoba.ca)
  • UCbase & miRfunc: a database of ultraconserved sequences and microRNA function. (vldb.org)
  • The PAZAR database of gene regulatory information coupled to the ORCA toolkit for the study of regulatory sequences. (vldb.org)
  • Transterm: a database to aid the analysis of regulatory sequences in mRNAs. (vldb.org)
  • DoOP: Databases of Orthologous Promoters, collections of clusters of orthologous upstream sequences from chordates and plants. (vldb.org)
  • HuSiDa - the human siRNA database: an open-access database for published functional siRNA sequences and technical details of efficient transfer into recipient cells. (vldb.org)
  • siRNAdb: a database of siRNA sequences. (vldb.org)
  • PA-GOSUB: a searchable database of model organism protein sequences with their predicted Gene Ontology molecular function and subcellular localization. (vldb.org)
  • A tool used to generate custom databases of FASTA sequences. (wikibooks.org)
  • A nucleic acid comprising any one of base sequences set forth in SEQ ID NO:1 to NO:104 in the Sequence Listing and a protein encoded by the nucleic acid, particularly a nucleic acid displaying differential expression levels in hepatoblastoma and normal liver based on comparison therebetween and a protein. (google.com)
  • In the field of bioinformatics, a sequence database is a type of biological database that is composed of a large collection of computerized ("digital") nucleic acid sequences, protein sequences, or other polymer sequences stored on a computer. (wikipedia.org)
  • There is much redundancy, as multiple labs may submit numerous sequences that are identical, or nearly identical, to others in the databases. (wikipedia.org)
  • TRACTOR_DB: a database of regulatory networks in gamma-proteobacterial genomes. (vldb.org)
  • According to the Genome Online Database ( http://www.genomesonline.org/gold_statistics.htm ) ( 5 , 6 ), there were 1020 completed bacterial genomes available during preparation of this article. (mcponline.org)
  • This tool allows the systematic searching of all catalogued three-dimensional nucleic acid PDB structures that contain secondary structure motifs such as mismatches, (a)symmetric internal loops, hairpin loops, and bulge loops. (rcsb.org)
  • The Protein Data Bank (PDB) at Brookhaven National Laboratory, a database containing experimentally determined three-dimensional structures of proteins, nucleic acids and other biological macromolecules, with approximately 8000 entries, is described. (iucr.org)
  • BPS: a database of RNA base-pair structures. (vldb.org)
  • CC+: a relational database of coiled-coil structures. (vldb.org)
  • PDB-Ligand: a ligand database based on PDB for the automated and customized classification of ligand-binding structures. (vldb.org)
  • PDBsum more: new summaries and analyses of the known 3D structures of proteins and nucleic acids. (vldb.org)
  • The PDBFlex database explores the intrinsic flexibility of protein structures by analyzing structural variations of the same protein across the archive. (rcsb.org)
  • The 2015 Nucleic Acids Research Database Issue contains 172 papers that include descriptions of 56 new molecular biology databases, and updates on 115 databases whose descriptions have been pre-viously published in NAR or other journals. (psu.edu)
  • Nucleic Acids Research , 45 (10). (elsevier.com)
  • In Nucleic Acids Research this week: database to house IndiGen sequencing data, database of SARS-CoV-2 docking scores, and more. (genomeweb.com)
  • An important resource for finding biological databases is a special yearly issue of the journal Nucleic Acids Research (NAR). (wikipedia.org)
  • Species-specific databases are available for some species, mainly those that are often used in research ( Model organisms ). (wikipedia.org)
  • Nucleic Acid Therapeutics is the leading journal in its field focusing on cutting-edge basic research, therapeutic applications, and drug development using nucleic acids or related compounds to alter gene expression. (liebertpub.com)
  • In this paper, in hope of recruiting database researchers into this rapidly progressing biology and medical research area, we introduce several challenges in genome informatics from the viewpoint of using existing DBMS for processing next-generation sequencer data. (springer.com)
  • A collaborative effort between the University of Colorado Museum, Denver Museum of Nature and Science, and Denver Botanic Gardens to convert separate collections into one distributed biodiversity database and research toolkit for the southern and central Rockies and adjacent plains. (tolweb.org)
  • An illustrated, relational database of invertebrate fossils for education and research. (tolweb.org)
  • The database is able to map the correlation of the different metabolites, offering visitors further research opportunities. (eurekalert.org)
  • Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in 2009. (vldb.org)
  • An MRspec database query and visualization engine with applications as a clinical diagnostic and research tool. (toronto.edu)
  • The database has been constantly growing and in the past two years between 2008 and 2010 it has exploded to contain over two and a half million protein IDs and eleven and a half million peptides. (wikibooks.org)
  • 2. The conductive CNT-biosensor according to claim 1 , wherein the bioreceptor is an enzymatic substrate, a ligand, an amino acid, a peptides, a nucleic acid, a lipid, a cofactor, or a carbohydrate. (google.com)
  • NALD thus annotates nucleic acids in complexes with ligands in terms of detailed binding interactions, binding motifs where binding occurs, binding properties, binding modes & classes and links to diseases may be in association with the ligands. (springer.com)
  • Fol-lowing the classification that has been introduced last year in order to simplify navigation of the en-tire issue, these articles are divided into eight sub-ject categories. (psu.edu)
  • This issue also includes an un-usually high number of cancer-related databases and other databases dedicated to genomic basics of dis-ease and potential drugs and drug targets. (psu.edu)
  • ture of this year's issue is the increased number of databases that exploit RNA-seq data, using them for such diverse tasks as mapping transcription start sites (1), analysing gene co-expression data =-=(2,3)-=-, and cataloguing chimeric transcripts (4). (psu.edu)
  • The Database Issue of NAR is freely available, and categorizes many of the publicly available online databases related to biology and bioinformatics . (wikipedia.org)
  • A companion database to the issue called the Online Molecular Biology Database Collection lists 1,380 online databases. (wikipedia.org)
  • 39 (Database issue): D561-8. (wikipedia.org)
  • 2010 Jan;38(Database issue):D105-10. (nih.gov)
  • 2014 Jan;42(Database issue):D358-63. (ucl.ac.uk)
  • 2011 Jan;39(Database issue):D420-6. (ebi.ac.uk)
  • 2010 Jan;38(Database issue):D736-42. (wikibooks.org)
  • Database issue, s. (wikipedia.org)
  • 2014;42(Database issue):D297-D303. (scienceblogs.com)
  • Nucleic Acids Res;33(Database issue): D178-82, 2005 Jan 01. (bvsalud.org)
  • The InterPro database, 2003 brings increased coverage and new features. (psu.edu)
  • InterPro, an integrated documentation resource of protein families, domains and functional sites, was created in 1999 as a means of amalgamating the major protein signature databases into one comprehensive resource. (psu.edu)
  • Kinomer v. 1.0: a database of systematically classified eukaryotic protein kinases. (vldb.org)
  • MoonProt, a database of 'moonlighting' proteins, and two new databases of protein-protein and other macromolecular complexes, ComPPI and the Complex Portal. (psu.edu)
  • Collecting experimentally determined binding affinity data exclusively for all types of biomolecular complexes in the Protein Data Bank, including protein-small molecule, nucleic acid-small molecule, protein-protein, and protein-nucleic acid complexes. (rcsb.org)
  • Once the tRNA is charged, a ribosome can transfer the amino acid from the tRNA onto a growing peptide , according to the genetic code. (wikipedia.org)
  • Synthetic peptide corresponding to Human Monocarboxylic acid transporter 1 aa 450 to the C-terminus (C terminal) conjugated to keyhole limpet haemocyanin. (abcam.com)
  • Mammalian cell entry (MCE) domains are conserved amino acid motifs that are widespread across bacteria 1 . (nature.com)
  • RNA Characterization of Secondary Structure Motifs (RNA CoSSMos) database. (rcsb.org)
  • The Iditis protein structure database provides the most comprehensive set of derived information about protein structure currently available and allows rapid searching for complex motifs. (iucr.org)
  • Biological database design, development, and long-term management is a core area of the discipline of bioinformatics . (wikipedia.org)
  • [4] Other collections of databases exist such as MetaBase and the Bioinformatics Links Collection. (wikipedia.org)
  • Existing DBMS, whose major targets are business applications, is not suited to managing these biological data because storing such large data to DBMS is time-consuming, and also current database queries cannot accommodate various types of bioinformatics tools written in various programming languages. (springer.com)
  • The database, which bioinformatics scientist Shu Tadaka from Tohoku University and his colleagues called jMorp, contains information about 306 metabolites and 256 common proteins found in humans. (eurekalert.org)
  • The rapid growth of the World Wide Web provides major new opportunities for distributed databases, especially in macromolecular science. (iucr.org)
  • The GO Consortium annotation dataset includes annotations imported from IntAct as well as other databases. (ucl.ac.uk)
  • The Functional RNA Database 3.0: databases to support mining and annotation of functional RNAs. (vldb.org)
  • CDD: specific functional annotation with the Conserved Domain Database. (vldb.org)
  • As a proof of concept we applied the database to whole-genome DNA sequencing data of one of the clinical isolates, which allowed the validation of 116 predicted single amino acid polymorphisms and the annotation of 131 N-terminal start sites. (mcponline.org)
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • The eBLOCKs database provides a tool for high-throughput genome annotation with maximal specificity and sensitivity . (bvsalud.org)
  • This can lead to a transitive annotation problem because there may be several such annotation transfers by sequence similarity between a particular database record and actual wet lab experimental information. (wikipedia.org)
  • Therefore, care must be taken when interpreting the annotation data from sequence databases. (wikipedia.org)
  • Data growth and its impact on the SCOP database: new developments. (rcsb.org)
  • SCOP database in 2004: refinements integrate structure and sequence family data. (sanger.ac.uk)
  • The Structural Classification of Proteins (SCOP) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationships. (sanger.ac.uk)
  • SCOP participates in a project that aims to rationalize and integrate the data on proteins held in several sequence and structure databases. (sanger.ac.uk)
  • In addition to the expanded set of static links to external resources, available at the level of domain entries, we have started modernization of the interface capabilities of SCOP allowing more dynamic links with other databases. (sanger.ac.uk)
  • A free database of commercially-available compounds for virtual screening. (rcsb.org)
  • database_human_plasma_compounds. (eurekalert.org)
  • SuperToxic: a comprehensive database of toxic compounds. (vldb.org)
  • One such example of this database type is the Mass Spectrometry Database Committee's comprehensive drug library [3] , which contains spectral data for pharmaceutical substances, metabolites, and intermediate compounds. (wikibooks.org)
  • The nucleic acids and ligands database (NALD) is concerned with the identification of ligands (drugs) that bind nucleic acids (NA) and provide users with sets of specific information in relation to the binding existing between both molecules. (springer.com)
  • NALD provides online access to these types of information while it focuses on ligands that bind nucleic acids with implications on diseases of high prevalence in Africa and in particular in Algeria and the Southern African Development Community (SADC) region such as HIV/AIDS, cancer, hepatitis, malaria and tuberculosis. (springer.com)
  • Rachedi A., Madida K. (2013) NALD: Nucleic Acids and Ligands Database. (springer.com)
  • The K D values of CB1 ligands in the ChEMBL database are predicted by QSAR random forest (RF) modeling for the CB1 receptor and known off-targets (TRPV1, mGlu5, 5-HT1a). (springer.com)
  • In this report, we present evidence that the complementary DNA-deduced protein product of sna contains five copies of a nucleic acid-binding finger motif previously identified in two transcription factors, and in the protein product of several putative regulatory genes. (nih.gov)
  • JASPAR (http://jaspar.genereg.net) is the leading open-access database of matrix profiles describing the DNA-binding patterns of transcription factors (TFs) and other proteins interacting with DNA in a sequence-specific manner. (nih.gov)
  • MachiBase: a Drosophila melanogaster 5'-end mRNA transcription database. (vldb.org)
  • PTM-Switchboard - a database of posttranslational modifications of transcription factors, the mediating enzymes and target genes. (vldb.org)
  • The MAPPER database: a multi-genome catalog of putative transcription factor binding sites. (vldb.org)
  • The database offers data integration in the form of links to the PDB, DrugBank, and other resources such as UniProt and PubMed databases. (springer.com)
  • The Entrez system provides search and retrieval operations for most of these data from 39 distinct databases. (nih.gov)
  • A new portable drawing tool for genomic features is also now available, as well as new ways to download the data, including web services, files for several relational database manager systems and text files including BioPAX format. (oxfordjournals.org)
  • Model Organism Databases are functional databases that provide species-specific data. (wikipedia.org)
  • Most biological databases are available through web sites that organise data such that users can browse through the data online. (wikipedia.org)
  • The Immune Epitope Database contains data related to antibody and T cell epitopes for humans, non-human primates, rodents, and other animal species. (rcsb.org)
  • As binding models are refined by newer data, the JASPAR database now uses versioning of matrices: in this release, 12% of the older models were updated to improved versions. (nih.gov)
  • The changes in the database set the system ready for more rapid acquisition of new high-throughput data sources. (nih.gov)
  • A database of phylogenetic trees and data matrices published in the primary systematic literature. (tolweb.org)
  • An online biotic database containing images and data for taxa used in analyses of Tropical American biodiversity over the past 25 million years. (tolweb.org)
  • The database is unique in that, instead of just displaying raw data, it offers visitors a chance to see how the different metabolites correlate to each other graphically, paving the way for further studies to identify how these metabolites and proteins relate to each other. (eurekalert.org)
  • Similar databases cover other countries or regions, such as the United Kingdom and the Republic of Ireland, but some have limitations due to inconsistent data collection or small sample size. (eurekalert.org)
  • UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. (vldb.org)
  • The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema. (vldb.org)
  • CS 6372 Biological Database Systems and Datamining (3 semester hours) This course emphasizes the concepts of database, data warehouse, data mining and their applications in biological science. (utdallas.edu)
  • Mass Spectrometry databases are a unique challenge for maintaining the vast quantity of data generated from an MS experiment due to both size and complexity issues. (wikibooks.org)
  • Although significant progress has been made in the standardization of these data types, there is still significant incongruence from one spectral database to another. (wikibooks.org)
  • Begun in 1970, the NIST standard reference database is a verbose collection of spectral data in a common data type, requiring both a minimal amount of data regarding the experiment as well as a standard format for the presentation of spectral data from a wide variety of MS applications. (wikibooks.org)
  • This article seeks to highlight the recent advances and modifications in the Proteomics Identifications Database and to point out the vital role it plays in the collection and storage of mass spectrometry (MS) data. (wikibooks.org)
  • The data found in the database comes from a vast range of experiments and is stored in a format that allows for simple and complex querying in a common format. (wikibooks.org)
  • A database that is centralized, public, and standards compliant and contains a variety of proteomics data. (wikibooks.org)
  • We generated a database for the Mycobacterium tuberculosis complex (using three strains of Mycobacterium bovis and five of M. tuberculosis ), and analyzed data collected from two laboratory strains and two clinical isolates of M. tuberculosis . (mcponline.org)
  • The Pfam database is a large collection of protein families, each represented by multiple sequence alignments and hidden Markov models. (rcsb.org)
  • Structural, mechanical and/or cell function indices for a plurality of tissue populations are determined, and then stored in a database. (google.co.uk)
  • In particular, a user measures parameters (e.g., structural, mechanical and/or cell function indices) associated with the user's tissue specimens and then compares this information to corresponding parameters for normal tissue in the database in order to classify the user's tissue specimens as either normal or abnormal. (google.co.uk)
  • Methods for nucleic acid preparation, random primed PCR amplification, and labeling were optimized to allow the sensitivity required for application with nucleic acid extracted from clinical materials and cultured isolates. (cdc.gov)
  • Analysis of epidemiologic studies from 1985 to 1993 in the database Medline on reproductive hazards of exposure to chemical products used in hairdressing. (ilo.org)
  • Relational database concepts of computer science and Information retrieval concepts of digital libraries are important for understanding biological databases. (wikipedia.org)
  • A relational database for invertebrate paleontology. (tolweb.org)
  • This can happen when two amino acids have different properties even if they have similar shapes-as is the case with Valine and Threonine . (wikipedia.org)
  • Although not all synthetases have a domain with the sole purpose of editing, they make up for it by having specific binding and activation of their affiliated amino acids. (wikipedia.org)
  • The amino acids are attached to the hydroxyl (-OH) group of the adenosine via the carboxyl (-COOH) group. (wikipedia.org)
  • The amino acids around the "opening" are grey, showing they're uncharged. (scienceblogs.com)
  • Could act as a detoxifying agent which removes D-amino acids accumulated during aging. (abcam.com)
  • Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. (abcam.com)
  • Biological databases are libraries of biological sciences, collected from scientific experiments, published literature, high-throughput experiment technology, and computational analysis. (wikipedia.org)
  • During a search of a nucleic acid database, Mascot uses the taxonomy of each entry to choose the correct genetic code. (matrixscience.com)
  • In humans, the 20 different types of aa-tRNA are made by the 20 different aminoacyl-tRNA synthetases, one for each amino acid of the genetic code . (wikipedia.org)
  • This has an impact in further proteomic studies, and also compromises the characterization of clinical isolates with many specific genetic variations that may not be represented in the selected database. (mcponline.org)
  • MAM-7 is reported to be an integral outer membrane protein on the cell surface that acts as an adhesin by binding to mammalian cells via phosphatidic acid and fibronectin 22 . (nature.com)
  • siRecords: a database of mammalian RNAi experiments and efficacies. (vldb.org)
  • The Degradome database: mammalian proteases and diseases of proteolysis. (vldb.org)
  • PolyA_DB: a database for mammalian mRNA polyadenylation. (vldb.org)
  • RNAdb - a comprehensive mammalian noncoding RNA database. (vldb.org)
  • CS 6360 Database Design (3 semester hours) Methods, principles, and concepts that are relevant to the practice of database software design. (utdallas.edu)
  • Methods to find driver mutations are usually classified into two main categories: mutation frequency-based analysis and bioinformatic predictions of functional effects of amino acid changes. (genetics.org)
  • Sequence databases can be searched using a variety of methods. (wikipedia.org)
  • The method also revealed the structure and function of many biological molecules, including vitamins , drugs, proteins and nucleic acids such as DNA . (wikipedia.org)
  • Database of measured binding affinities, focusing chiefly on the interactions of protein considered to be drug-targets with small, drug-like molecules. (rcsb.org)
  • W.C. Barker, D.G. George, and L.T. Hunt , Protein Sequence Database. (elsevier.com)
  • R.F. Doolittle , Searching through Sequence Databases. (elsevier.com)
  • S. Henikoff, J.C. Wallace, and J.P. Brown , Finding Protein Similarities with Nucleotide Sequence Databases. (elsevier.com)
  • BLAST provides sequence similarity searches of GenBank and other sequence databases. (nih.gov)
  • Biological databases can be broadly classified into sequence, structure and functional databases. (wikipedia.org)
  • GtRNAdb: a database of transfer RNA genes detected in genomic sequence. (vldb.org)
  • The EMBL Nucleotide Sequence Database. (vldb.org)
  • STING Report: convenient web-based application for graphic and tabular presentations of protein sequence, structure and function descriptors from the STING database. (vldb.org)
  • The UniProt database is an example of a protein sequence database. (wikipedia.org)
  • Records in sequence databases are deposited from a wide range of sources, from individual researchers to large genome sequencing centers. (wikipedia.org)
  • Once a sequence has been annotated based on similarity to others, and itself deposited in the database, it can also become the basis for future annotations. (wikipedia.org)
  • Complete bimonthly releases and daily updates of the GenBank database are available by FTP. (nih.gov)
  • Links to Genbank and other molecular and literature databases. (tolweb.org)
  • R.: IntAct: an open source molecular interaction database. (psu.edu)
  • author = {Henning Hermjakob and Luisa Montecchi-palazzi and Chris Lewington and Sugath Mudali and Samuel Kerrien and Ra Orchard and Martin Vingron and Bernd Roechert and Peter Roepstorff and Alfonso Valencia and Hanah Margalit and John Armstrong and Amos Bairoch and Gianni Cesareni and David Sherman and Rolf Apweiler}, title = {R.: IntAct: an open source molecular interaction database. (psu.edu)
  • Orchard S. Molecular interaction databases. (ucl.ac.uk)
  • The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis. (vldb.org)
  • IntAct provides an open source database and toolkit for the storage, presentation and analysis of protein interactions. (psu.edu)
  • The Journal examines many new approaches for using nucleic acids as therapeutic agents or in modifying nucleic acids for therapeutic purposes including: oligonucleotides, gene modification, aptamers, RNA nanoparticles, and ribozymes. (liebertpub.com)
  • Nucleic Acid Therapeutics is a rapid-publication Journal, with peer review averaging 25 days from submission to first decision, and online publication of the article within four weeks of acceptance. (liebertpub.com)
  • Database: the journal of biological databases and curation. (wikipedia.org)
  • Although Mascot could try to determine whether a database entry is mitochondrial by performing a keyword search of the FASTA description, this is unreliable. (matrixscience.com)
  • Citation Query Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. (psu.edu)
  • Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. (psu.edu)
  • Minimotif miner 2nd release: a database and web system for motif search. (vldb.org)
  • Databases are important tools in assisting scientists to analyze and explain a host of biological phenomena from the structure of biomolecules and their interaction, to the whole metabolism of organisms and to understanding the evolution of species . (wikipedia.org)
  • A summary of macromlecular structure databases developed to date. (iucr.org)
  • AS-ALPS: a database for analyzing the effects of alternative splicing on protein structure, interaction and network in human and mouse. (vldb.org)
  • PDBSite: a database of the 3D structure of protein functional sites. (vldb.org)
  • TRED: a Transcriptional Regulatory Element Database and a platform for in silico gene regulation studies. (vldb.org)
  • Functional databases provide information on the physiological role of gene products, for example enzyme activities, mutant phenotypes, or biological pathways. (wikipedia.org)
  • An aminoacyl-tRNA synthetase ( aaRS or ARS ), also called tRNA-ligase, is an enzyme that attaches the appropriate amino acid onto its tRNA . (wikipedia.org)
  • The database of experimentally supported targets: a functional update of TarBase. (vldb.org)
  • A tool used to view spectra from within the Proteomics Identifications Database. (wikibooks.org)
  • Many efforts have been put into creation of more suitable, proteomics-friendly databases. (mcponline.org)