Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Databases devoted to knowledge about specific genes and gene products.
Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
Extensive collections, reputedly complete, of references and citations to books, articles, publications, etc., generally on a single subject or specialized subject area. Databases can operate through automated files, libraries, or computer disks. The concept should be differentiated from DATABASES, FACTUAL which is used for collections of data and facts apart from bibliographic references to them.
Databases containing information about NUCLEIC ACIDS such as BASE SEQUENCE; SNPS; NUCLEIC ACID CONFORMATION; and other properties. Information about the DNA fragments kept in a GENE LIBRARY or GENOMIC LIBRARY is often maintained in DNA databases.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Organized activities related to the storage, location, search, and retrieval of information.
Software designed to store, manipulate, manage, and control data for specific uses.
Sequential operating programs and data which instruct the functioning of a digital computer.
The portion of an interactive computer program that issues messages to and receives commands from a user.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Databases devoted to knowledge about specific chemicals.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
The systematic study of the complete DNA sequences (GENOME) of organisms.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.
Activities performed to identify concepts and aspects of published information and research reports.
A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Integrated set of files, procedures, and equipment for the storage, manipulation, and retrieval of information.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.
Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.
A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)
Systems where the input data enter the computer directly from the point of origin (usually a terminal or workstation) and/or in which output data are transmitted directly to that terminal point of origin. (Sippl, Computer Dictionary, 4th ed)
A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)
The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.
Specific languages used to prepare computer programs.
The relationships of groups of organisms as reflected by their genetic makeup.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
An optical disk storage system for computers on which data can be read or from which data can be retrieved but not entered or modified. A CD-ROM unit is almost identical to the compact disk playback device for home use.
A publication issued at stated, more or less regular, intervals.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Specifications and instructions applied to the software.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
Methods for determining interaction between PROTEINS.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The influence of study results on the chances of publication and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
Systematic organization, storage, retrieval, and dissemination of specialized information, especially of a scientific or technical nature (From ALA Glossary of Library and Information Science, 1983). It often involves authenticating or validating information.
Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Computer processing of a language with rules that reflect and describe current usage rather than prescribed usage.
The creation and maintenance of medical and vital records in multiple institutions in a manner that will facilitate the combined use of the records of identified individuals.
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
The science concerned with the benefit and risk of drugs used in populations and the analysis of the outcomes of drug therapies. Pharmacoepidemiologic data come from both clinical trials and epidemiological studies with emphasis on methods for the detection and evaluation of drug-related adverse effects, assessment of risk vs benefit ratios in drug therapy, patterns of drug utilization, the cost-effectiveness of specific drugs, methodology of postmarketing surveillance, and the relation between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines. (Pharmacoepidemiol Drug Saf 1992;1(1); J Pharmacoepidemiol 1990;1(1))
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.
Any method used for determining the location of and relative distances between genes on a chromosome.
The protein complement of an organism coded for by its genome.
Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.
The genetic complement of a plant (PLANTS) as represented in its DNA.
Terms or expressions which provide the major means of access by subject to the bibliographic unit.
The systematic study of the complete complement of proteins (PROTEOME) of organisms.
Services providing pharmaceutic and therapeutic drug information and consultation.
Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.
The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various aspects of health care and medicine.
The circulation or wide dispersal of information.
The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.
A research and development program initiated by the NATIONAL LIBRARY OF MEDICINE to build knowledge sources for the purpose of aiding the development of systems that help health professionals retrieve and integrate biomedical information. The knowledge sources can be used to link disparate information systems to overcome retrieval problems caused by differences in terminology and the scattering of relevant information across many databases. The three knowledge sources are the Metathesaurus, the Semantic Network, and the Specialist Lexicon.
The field of information science concerned with the analysis and dissemination of data through the application of computers.
A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.
A multistage process that includes cloning, physical mapping, subcloning, sequencing, and information analysis of an RNA SEQUENCE.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
In INFORMATION RETRIEVAL, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed)
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
Computerized compilations of information units (text, sound, graphics, and/or video) interconnected by logical nonlinear linkages that enable users to follow optimal paths through the material and also the systems used to create and display this information. (From Thesaurus of ERIC Descriptors, 1994)
The application of technology to the solution of medical problems.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A coordinated effort of researchers to map (CHROMOSOME MAPPING) and sequence (SEQUENCE ANALYSIS, DNA) the human GENOME.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
The genetic complement of a BACTERIA as represented in its DNA.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The degree of similarity between sequences. Studies of AMINO ACID SEQUENCE HOMOLOGY and NUCLEIC ACID SEQUENCE HOMOLOGY provide useful information about the genetic relatedness of genes, gene products, and species.
Evaluation of biomedical technology in relation to cost, efficacy, utilization, etc., and its future impact on social, ethical, and legal systems.
The relationships between symbols and their meanings.
Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as RANDOMIZED CONTROLLED TRIALS AS TOPIC.
The commitment in writing, as authentic evidence, of something having legal importance. The concept includes certificates of birth, death, etc., as well as hospital, medical, and other institutional records.
A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.
One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
Data processing largely performed by automatic means.
Books designed by the arrangement and treatment of their subject matter to be consulted for definite terms of information rather than to be read consecutively. Reference books include DICTIONARIES; ENCYCLOPEDIAS; ATLASES; etc. (From the ALA Glossary of Library and Information Science, 1983)
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Integrated, computer-assisted systems designed to store, manipulate, and retrieve information concerned with the administrative and clinical aspects of providing medical services within the hospital.
The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
Computer-based representation of physical systems and phenomena such as chemical processes.
Elements of limited time intervals, contributing to particular results or situations.
Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)
Systems composed of a computer or computers, peripheral equipment, such as disks, printers, and terminals, and telecommunications capabilities.
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Precise procedural mathematical and logical operations utilized in the study of medical information pertaining to health care.
A measurement index derived from a modification of standard life-table procedures and designed to take account of the quality as well as the duration of survival. This index can be used in assessing the outcome of health care procedures or services. (BIOETHICS Thesaurus, 1994)
Genotypic differences observed among individuals in a population.
Description of pattern of recurrent functions or procedures frequently found in organizational processes, such as notification, decision, and action.
Overlapping of cloned or sequenced DNA to construct a continuous region of a gene, chromosome or genome.
Information application based on a variety of coding methods to minimize the amount of data to be stored, retrieved, or transmitted. Data compression can be applied to various forms of data, such as images and signals. It is used to reduce costs and increase efficiency in the maintenance of large volumes of data.
Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The act of testing the software for compliance with a standard.
The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
The confinement of a patient in a hospital.
The application of genetic analyses and MOLECULAR DIAGNOSTIC TECHNIQUES to legal matters and crime analysis.
The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)
Ordered compilations of item descriptions and sufficient information to afford access to them.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
The visual display of data in a man-machine system. An example is when data is called from the computer and transmitted to a CATHODE RAY TUBE DISPLAY or LIQUID CRYSTAL display.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
The privacy of information and its protection against unauthorized disclosure.
Statistical models of the production, distribution, and consumption of goods and services, as well as of financial considerations. For the application of statistics to the testing and quantifying of economic theories MODELS, ECONOMETRIC is available.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
The chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (ANABOLISM) and the breakdown (CATABOLISM) of organic materials utilized by the living organism.
A cabinet department in the Executive Branch of the United States Government concerned with overall planning, promoting, and administering programs pertaining to VETERANS. It was established March 15, 1989 as a Cabinet-level position.
Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Techniques of nucleotide sequence analysis that increase the range, complexity, sensitivity, and accuracy of results by greatly increasing the scale of operations and thus the number of nucleotides, and the number of copies of each nucleotide sequenced. The sequencing may be done by analysis of the synthesis or ligation products, hybridization to preexisting sequences, etc.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A stochastic process such that the conditional probability distribution for a state at any future instant, given the present state, is unaffected by any additional knowledge of the past history of the system.
An infant during the first month after birth.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The functional hereditary units of PLANTS.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Graphs representing sets of measurable, non-covalent physical contacts with specific PROTEINS in living organisms or in cells.
Any deviation of results or inferences from the truth, or processes leading to such deviation. Bias can result from several sources: one-sided or systematic variations in measurement from the true value (systematic error); flaws in study design; deviation of inferences, interpretations, or analyses based on flawed data or data collection; etc. There is no sense of prejudice or subjectivity implied in the assessment of bias under these conditions.
The quality or state of relating to or affecting two or more nations. (After Merriam-Webster Collegiate Dictionary, 10th ed)
Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.
The design, completion, and filing of forms with the insurer.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are CASE-CONTROL STUDIES; COHORT STUDIES; and CROSS-SECTIONAL STUDIES.
Automated systems applied to the patient care process including diagnosis, therapy, and systems of communicating medical data within the health care setting.
The degree of 3-dimensional shape similarity between proteins. It can be an indication of distant AMINO ACID SEQUENCE HOMOLOGY and used for rational DRUG DESIGN.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A province of eastern Canada. Its capital is Quebec. The region belonged to France from 1627 to 1763 when it was lost to the British. The name is from the Algonquian quilibek meaning the place where waters narrow, referring to the gradually narrowing channel of the St. Lawrence or to the narrows of the river at Cape Diamond. (From Webster's New Geographical Dictionary, 1988, p993 & Room, Brewer's Dictionary of Names, 1992, p440)
Discussion of documents issued by local, regional, or national governments or by their agencies or subdivisions.
Directions written for the obtaining and use of DRUGS.
A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
Controlled operation of an apparatus, process, or system by mechanical or electronic devices that take the place of human organs of observation, effort, and decision. (From Webster's Collegiate Dictionary, 1993)
A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)
Individual's rights to obtain and use information collected or generated by others.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.
Media that facilitate transportability of pertinent information concerning patient's illness across varied providers and geographic locations. Some versions include direct linkages to online consumer health information that is relevant to the health conditions and treatments related to a specific patient.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study).
A management function in which standards and guidelines are developed for the development, maintenance, and handling of forms and records.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.

Relatedness of baculovirus and gypsy retrotransposon envelope proteins. (1/7499)

BACKGROUND: Current evidence suggests that lepidopteran baculoviruses may be divided into two phylogenetic groups based on their envelope fusion proteins. One group utilizes gp64, a low pH-dependent envelope fusion protein, whereas the other employs a protein family (e.g. LD130 in the Lymantria dispar nucleopolyhedrovirus) unrelated to gp64, but that is also low pH-dependent. Database searches with members of the LD130 protein family often record significant levels of homology to envelope proteins from a number of insect retrovirus-like transposable elements of the gypsy class. In this report, the significance of the homology between these two types of envelope proteins is analyzed. RESULTS: The significance of the alignment scores was evaluated using Z-scores that were calculated by comparing the observed alignment score to the distribution of scores obtained for alignments after one of the sequences was subjected to 100 random shuffles of its sequence. These analyses resulted in Z-scores of >9 for members of the LD130 family when compared to most gypsy envelope proteins. Furthermore, in addition to significant levels of sequence homology and the presence of predicted signal sequences and transmembrane domains, members of this family contain a possible a furin cleavage motif, a conserved motif downstream of this site, predicted coiled-coil domains, and a pattern of conserved cysteine residues. CONCLUSIONS: These analyses provide a link between envelope proteins from a group of insect retrovirus-like elements and a baculovirus protein family that includes low-pH-dependent envelope fusion proteins. The ability of gypsy retroelements to transpose from insect into baculovirus genomes suggests a pathway for the exchange of this protein between these viral families.  (+info)

Cultural aspects of cancer genetics: setting a research agenda. (2/7499)

BACKGROUND: Anecdotal evidence suggests that people from non-Anglo-Celtic backgrounds are under-represented at familial cancer clinics in the UK, the USA, and Australia. This article discusses cultural beliefs as a potential key barrier to access, reviews previous empirical research on cultural aspects of cancer genetics, draws implications from findings, and sets a research agenda on the inter-relationships between culture, cancer genetics, and kinship. METHODS: The CD-ROM databases MEDLINE, PsychLIT, CINAHL, and Sociological Abstracts were searched from 1980 onwards. RESULTS: Cultural aspects of cancer genetics is the focus of an emerging body of publications. Almost all studies assessed African-American women with a family history of breast cancer and few studies included more diverse samples, such as Americans of Ashkenazi Jewish background or Hawaiian- and Japanese-Americans. Our analysis of published reports suggests several directions for future research. First, an increased focus on various Asian societies appears warranted. Research outside North America could explore the extent to which findings can be replicated in other multicultural settings. In addition, control group designs are likely to benefit from systematically assessing culture based beliefs and cultural identity in the "majority culture" group used for comparative purposes. CONCLUSION: More data on which to base the provision of culturally appropriate familial cancer clinic services to ethnically diverse societies are needed. Empirical data will assist with culturally appropriate categorisation of people from other cultures into risk groups based on their family histories and provide the basis for the development of culturally appropriate patient education strategies and materials.  (+info)

An efficient algorithm for finding short approximate non-tandem repeats. (3/7499)

We study the problem of approximate non-tandem repeat extraction. Given a long subject string S of length N over a finite alphabet Sigma and a threshold D, we would like to find all short substrings of S of length P that repeat with at most D differences, i.e., insertions, deletions, and mismatches. We give a careful theoretical characterization of the set of seeds (i.e., some maximal exact repeats) required by the algorithm, and prove a sublinear bound on their expected numbers. Using this result, we present a sub-quadratic algorithm for finding all short (i.e., of length O(log N)) approximate repeats. The running time of our algorithm is O(DN(3pow(epsilon)-1)log N), where epsilon = D/P and pow(epsilon) is an increasing, concave function that is 0 when epsilon = 0 and about 0.9 for DNA and protein sequences.  (+info)

Fast optimal leaf ordering for hierarchical clustering. (4/7499)

We present the first practical algorithm for the optimal linear leaf ordering of trees that are generated by hierarchical clustering. Hierarchical clustering has been extensively used to analyze gene expression data, and we show how optimal leaf ordering can reveal biological structure that is not observed with an existing heuristic ordering method. For a tree with n leaves, there are 2(n-1) linear orderings consistent with the structure of the tree. Our optimal leaf ordering algorithm runs in time O(n(4)), and we present further improvements that make the running time of our algorithm practical.  (+info)

GEST: a gene expression search tool based on a novel Bayesian similarity metric. (5/7499)

Gene expression array technology has made possible the assay of expression levels of tens of thousands of genes at a time; large databases of such measurements are currently under construction. One important use of such databases is the ability to search for experiments that have similar gene expression levels as a query, potentially identifying previously unsuspected relationships among cellular states. Such searches depend crucially on the metric used to assess the similarity between pairs of experiments. The complex joint distribution of gene expression levels, particularly their correlational structure and non-normality, make simple similarity metrics such as Euclidean distance or correlational similarity scores suboptimal for use in this application. We present a similarity metric for gene expression array experiments that takes into account the complex joint distribution of expression values. We provide a computationally tractable approximation to this measure, and have implemented a database search tool based on it. We discuss implementation issues and efficiency, and we compare our new metric to other standard metrics.  (+info)

New approaches for reconstructing phylogenies from gene order data. (6/7499)

We report on new techniques we have developed for reconstructing phylogenies on whole genomes. Our mathematical techniques include new polynomial-time methods for bounding the inversion length of a candidate tree and new polynomial-time methods for estimating genomic distances which greatly improve the accuracy of neighbor-joining analyses. We demonstrate the power of these techniques through an extensive performance study based on simulating genome evolution under a wide range of model conditions. Combining these new tools with standard approaches (fast reconstruction with neighbor-joining, exploration of all possible refinements of strict consensus trees, etc.) has allowed us to analyze datasets that were previously considered computationally impractical. In particular, we have conducted a complete phylogenetic analysis of a subset of the Campanulaceae family, confirming various conjectures about the relationships among members of the subset and about the principal mechanism of evolution for their chloroplast genome. We give representative results of the extensive experimentation we conducted on both real and simulated datasets in order to validate and characterize our approaches. We find that our techniques provide very accurate reconstructions of the true tree topology even when the data are generated by processes that include a significant fraction of transpositions and when the data are close to saturation.  (+info)

Designing fast converging phylogenetic methods. (7/7499)

Absolute fast converging phylogenetic reconstruction methods are provably guaranteed to recover the true tree with high probability from sequences that grow only polynomially in the number of leaves, once the edge lengths are bounded arbitrarily from above and below. Only a few methods have been determined to be absolute fast converging; these have all been developed in just the last few years, and most are polynomial time. In this paper, we compare pre-existing fast converging methods as well as some new polynomial time methods that we have developed. Our study, based upon simulating evolution under a wide range of model conditions, establishes that our new methods outperform both neighbor joining and the previous fast converging methods, returning very accurate large trees, when these other methods do poorly.  (+info)

Inferring subnetworks from perturbed expression profiles. (8/7499)

Genome-wide expression profiles of genetic mutants provide a wide variety of measurements of cellular responses to perturbations. Typical analysis of such data identifies genes affected by perturbation and uses clustering to group genes of similar function. In this paper we discover a finer structure of interactions between genes, such as causality, mediation, activation, and inhibition by using a Bayesian network framework. We extend this framework to correctly handle perturbations, and to identify significant subnetworks of interacting genes. We apply this method to expression data of S. cerevisiae mutants and uncover a variety of structured metabolic, signaling and regulatory pathways.  (+info)

2007 (English)In: The Ethics and Governance of Human Genetic Databases: European Perspectives / [ed] Matti Häyry, Ruth Chadwick, Vilhjálmur Árnason & Gardar Árnason, Cambridge: Cambridge University Press, 2007, no 4, 108-119 p.Chapter in book (Other academic) ...
770 full-length cDNAs. Analysis of the mouse transcriptome based on functional annotation of 60s profile, publications, research topics, and co-authors
The Gene Expression Database (GXD) is a community resource that stores and integrates expression information for the laboratory mouse, with a particular emphasis on mouse development, and makes these data freely available in formats appropriate for comprehensive analysis. GXD is implemented as a relational database and integrated with the Mouse Genome Database (MGD) to enable global analysis of genotype, expression and phenotype information. Interconnections with sequence databases and with databases from other species further extend GXDs utility for the analysis of gene expression data. GXD is available through the Mouse Genome Informatics Web Site at http://www.informatics.jax.org/
In a continuation of a 2014 conference that explored regulatory considerations and strategies for next-generation sequencing, the Friends of Cancer Research, with support from Alexandria Real Estate Equities, Inc, Pasadena, California, met to discuss the issues and problems of coordinating drug and diagnostic development, specifically the use of curated databases.. Ellen V. Sigal, PhD, Chair and Founder of Friends of Cancer Research, introduced the gathering by noting that high-throughput genomic technologies, including next-generation sequencing, allow for rapid assessment of many analytes and can help predict patients risk of developing certain cancers and how they might respond to therapies. There are many advantages of high-throughput sequencing over that of a single analyte, but demonstrating its adequacy for clinical use is challenging, particularly the tension between the need to ensure validity and the practical limitations of submitting data for every possible variant.. She added ...
TY - JOUR. T1 - Analysis of the mouse transcriptome for genes involved in the function of the nervous system. AU - Gustincich, Stefano. AU - Batalov, Serge. AU - Beisel, Kirk W.. AU - Bono, Hidemasa. AU - Carninci, Piero. AU - Fletcher, Colin F.. AU - Grimmond, Sean. AU - Hirokawa, Nobutaka. AU - Jarvis, Erich D.. AU - Jegla, Tim. AU - Kawasawa, Yuka. AU - LeMieux, Julianna. AU - Miki, Harukata. AU - Raviola, Elio. AU - Teasdale, Rohan D.. AU - Tominaga, Naoko. AU - Yagi, Ken. AU - Zimmer, Andreas. AU - Arakawa, Takahiro. AU - Waki, Kazunori. AU - Kawai, Jun. AU - Hayashizaki, Yoshihide. AU - Okazaki, Yasushi. PY - 2003/6/1. Y1 - 2003/6/1. N2 - We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins. We also identified previously unknown candidates for ...
The rich knowledge of morphological variation among organisms reported in the systematic literature has remained in free-text format, impractical for use in large-scale synthetic phylogenetic work. This noncomputable format has also precluded linkage to the large knowledgebase of genomic, genetic, developmental, and phenotype data in model organism databases. We have undertaken an effort to prototype a curated, ontology-based evolutionary morphology database that maps to these genetic databases (http://kb.phenoscape.org) to facilitate investigation into the mechanistic basis and evolution of phenotypic diversity. Among the first requirements in establishing this database was the development of a multispecies anatomy ontology with the goal of capturing anatomical data in a systematic and computable manner. An ontology is a formal representation of a set of concepts with defined relationships between those concepts. Multispecies anatomy ontologies in particular are an efficient way to represent ...
ZFIN serves as the zebrafish model organism database. The long term goals for ZFIN are a) to be the community database resource for the laboratory use of zebrafish, b) to develop and support integrated zebrafish genetic, genomic and developmental information, c) to maintain the definitive reference data sets of zebrafish research information, d) to link this information extensively to corresponding data in other model organism and human databases, e) to facilitate the use of zebrafish as a model for human biology and f) to serve the needs of the research community ...
The browser lines at the beginning of the custom track indicate which native tracks to turn on along their visibilities, while the hide all line turns all the other native tracks off. In addition to these basic instructions there are many more examples on the UCSC Genome Browser Wiki.. What about when you want to view a genome and annotations not hosted on our site? If you have a FASTA file of your genome available, you can use faToTwoBit to convert your genome into a 2bit file, then make an assembly hub out of your data. Once youve created your hub, you can view the hub with the hubUrl setting. As an example, I have hosted an assembly hub for Arabadopsis thaliana here, and I can view the hub via a single URL like so ...
The GMOD project is a confederation of intercompatible open-source projects developing software tools for storing, managing, curating, and publishing biological data. Although the GMOD project originated from the goal of developing a generic tool set for common needs among model organism databases, GMOD tools are meanwhile used by many large and small, collaborative and single-investigator biological database projects for the dissemination of results of experimental research and curated knowledge. GMODs software tools provide a powerful and feature-rich basis for working with biological, in particular genomic and other molecular data. However, due to GMODs historical emphasis on single-genome projects many GMOD tools still lack features that are critical to effectively support the comparative, phylogenetic, and natural diversity-oriented questions frequently asked in evolutionary research. Recent developments have given rise to a window of opportunity for forging collaborations towards filling ...
Researchers from the University of Maryland School of Medicines (UMSOM) Institute for Genome Sciences (IGS) have created VIRGO (human vaginal non-redundant gene catalog): the first genomic catalog of the vaginal microbiome.
GeneWeaver is a web application for the integrated cross-species analysis of functional genomics data to find convergent evidence from heterogeneous sources. The application consists of a large database of gene sets curated from multiple public data resources and curated submissions, along with a suite of analysis tools designed to allow flexible, customized workflows through web-based interactive analysis or scripted API driven analysis. Gene sets come from multiple widely studied species and include ontology annotations, brain gene expression atlases, systems genetic study results, gene regulatory information, pathway databases, drug interaction databases and many other sources. Users can retrieve, store, analyze and share gene sets through a graded access system. Analysis tools are based on combinatorics and statistical methods for comparing, contrasting, and classifying gene sets based on their members.. ...
GeneWeaver is a web application for the integrated cross-species analysis of functional genomics data to find convergent evidence from heterogeneous sources. The application consists of a large database of gene sets curated from multiple public data resources and curated submissions, along with a suite of analysis tools designed to allow flexible, customized workflows through web-based interactive analysis or scripted API driven analysis. Gene sets come from multiple widely studied species and include ontology annotations, brain gene expression atlases, systems genetic study results, gene regulatory information, pathway databases, drug interaction databases and many other sources. Users can retrieve, store, analyze and share gene sets through a graded access system. Analysis tools are based on combinatorics and statistical methods for comparing, contrasting, and classifying gene sets based on their members.. ...
To whom it may concern: The completion of the sequencing of the entire DNA of the S. cerevisae genome, is a major event in the history of biology. All those involved are to be congratulated as we now have the first full genetic blueprint of a free living eukaryotic organism. The analysis of these gene products will provide us with a powerful tool for reading the genomes of other eukaryotes, particularly those of higher eukaryotes, which represent the majority of the data currently in the genetic databases. The analysis of the yeast genome is provided a useful framework for the annotation of many of the complete genome projects currently nearing completion, as well as the upcoming human genome. The yeast sequence information used to create this yeast webpage was provided by the GeneQuiz Consortium and the Mips Genome Commission . We have made an initial attempt to integrate these two data structures as well as supplement their annotation with that obtained ,From a set of functionally diagnostic ...
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TY - JOUR. T1 - Mining cancer gene expression databases for latent information on intronic microRNAs. AU - Monterisi, Simona. AU - DArio, Giovanni. AU - Dama, Elisa. AU - Rotmensz, Nicole. AU - Confalonieri, Stefano. AU - Tordonato, Chiara. AU - Troglio, Flavia. AU - Bertalot, Giovanni. AU - Maisonneuve, Patrick. AU - Viale, Giuseppe. AU - Nicassio, Francesco. AU - Vecchi, Manuela. AU - Di Fiore, Pier Paolo. AU - Bianchi, Fabrizio. PY - 2015/2/1. Y1 - 2015/2/1. N2 - Around 50% of all human microRNAs reside within introns of coding genes and are usually co-transcribed. Gene expression datasets, therefore, should contain a wealth of miRNA-relevant latent information, exploitable for many basic and translational research aims. The present study was undertaken to investigate this possibility. We developed an in silico approach to identify intronic-miRNAs relevant to breast cancer, using public gene expression datasets. This led to the identification of a miRNA signature for aggressive breast ...
de Leeuw N, Dijkhuizen T, Hehir-Kwa JY, Carter NP, Feuk L, Firth HV, Kuhn RM, Ledbetter DH, Martin CL, van Ravenswaaij-Arts CM, Scherer SW, Shams S, Van Vooren S, Sijmons R, Swertz M, Hastings R. Diagnostic interpretation of array data using public databases and internet sources. Hum Mutat. 2012 Jun;33(6):930-40. PMID: 26285306; PMC: PMC5027376 Dreszer TR, Karolchik D, Zweig AS, Hinrichs AS, Raney BJ, Kuhn RM, Meyer LR, Wong M, Sloan CA, Rosenbloom KR, Roe G, Rhead B, Pohl A, Malladi VS, Li CH, Learned K, Kirkup V, Hsu F, Harte RA, Guruvadoo L, Goldman M, Giardine BM, Fujita PA, Diekhans M, Cline MS, Clawson H, Barber GP, Haussler D, Kent WJ The UCSC Genome Browser database: extensions and updates 2011. Nucleic Acids Res. 2012 Jan;40(Database issue):D918-23. PMID: 22086951; PMC: PMC3245018. ENCODE Project Consortium, Dunham I, Kundaje A, Aldred SF, Collins PJ, Davis CA, Doyle F, Epstein CB, Frietze S, Harrow J et al. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 ...
TY - JOUR. T1 - Transcript annotation in FANTOM3. T2 - Mouse gene catalog based on physical cDNAs. AU - Maeda, Norihiro. AU - Kasukawa, Takeya. AU - Oyama, Rieko. AU - Gough, Julian. AU - Frith, Martin. AU - Engström, Pär G.. AU - Lenhard, Boris. AU - Aturaliya, Rajith N.. AU - Batalov, Serge. AU - Beisel, Kirk W.. AU - Bult, Carol J.. AU - Fletcher, Colin F.. AU - Forrest, Alistair R.R.. AU - Furuno, Masaaki. AU - Hill, David. AU - Itoh, Masayoshi. AU - Kanamori-Katayama, Mutsumi. AU - Katayama, Shintaro. AU - Katoh, Masaru. AU - Kawashima, Tsugumi. AU - Quackenbushb, John. AU - Ravasi, Timothy. AU - Ring, Brian Z.. AU - Shibata, Kazuhiro. AU - Sugiura, Koji. AU - Takenaka, Yoichi. AU - Teasdale, Rohan D.. AU - Wells, Christine A.. AU - Zhu, Yunxia. AU - Kai, Chikatoshi. AU - Kawai, Jun. AU - Hume, David A.. AU - Carninci, Piero. AU - Hayashizaki, Yoshihide. PY - 2006/4/1. Y1 - 2006/4/1. N2 - The international FANTOM consortium aims to produce a comprehensive picture of the mammalian ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
MicroRNAs (miRNAs) play a vital role in the development of ovarian cancer (OC). The aim of this study to investigate the prognostic value and potential signaling pathways of hsa-miR-9-5p (miR-9) in OC through literature review and bioinformatics methods. The expression of miR-9 in OC was assessed using the public datasets from the Gene Expression Omnibus (GEO) database. And a literature review was also performed to investigate the correlation between miR-9 expression and the OC prognosis. Two mRNA datasets (GSE18520 and GSE36668) of OC tissues and normal ovarian tissues (NOTs) were downloaded from GEO to identify the differentially expressed genes (DEGs). The target genes of hsa-miR-9-5p (TG-miR-9-5p) were predicted using miRWALK3.0 and TargetScan. Then the gene overlaps between DEGs in OC and the predicted TG-miR-9-5p were confirmed using a Venn diagram. After that, overlapping genes were subjected to Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway
The HGNC Comparison of Orthology Predictions (HCOP) search is a tool that integrates and displays the orthology assertions predicted for a specified human gene, or set of human genes, by eggNOG, Ensembl Compara, HGNC, HomoloGene, Inparanoid, NCBI Gene Orthology, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, PomBase, TreeFam and ZFIN.
The HGNC Comparison of Orthology Predictions (HCOP) search is a tool that integrates and displays the orthology assertions predicted for a specified human gene, or set of human genes, by eggNOG, Ensembl Compara, HGNC, HomoloGene, Inparanoid, NCBI Gene Orthology, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, PomBase, TreeFam and ZFIN.
The remainder of corrections will most likely require the curator to go back to the paper to determine how the entity in the extension is related to the primary GO term annotated (this demonstrates that the meaning of the existing annotation is not clear and should be modified). If a curator comes across an example that is not covered by this guidance, and it is not clear how the annotation should be updated, the example should be brought to an annotation call to be discussed and resolved. Additional recommendations have been made for specific annotations on previous annotation calls; http://wiki.geneontology.org/index.php/Annotation_Conf._Call,_June_23,_2015 http://wiki.geneontology.org/index.php/Annotation_Conf._Call,_July_28,_2015 See the Excel spreadsheet containing details of annotations using deprecated relations, with assigned_by information ...
Once the MODs annotations have been integrated into our database, UniProt-GOA will provide the MOD with a file in the GAF2.0 format containing the entire set of GO annotations that match the taxon identifier(s) the MOD is responsible for as well as any additional annotations the MOD has created to other taxons. When importing the annotations back into their own database, the MOD can either note the updates made in this set from the changes in the date attached to each annotation (dates indicate when the last edit was made to the annotation) or they can carry out a full delete and reload of their GO annotation set. Any annotations that we cannot accept from the MOD, but which the MOD wants to keep can be appended to the supplied GAF by the MOD, e.g. annotations to non-coding RNAs, annotations using internal references that arent mapped to a GO_REF, IEA annotations, etc. UniProt-GOA will not store the annotations that are excluded, so it is up to the MOD to keep a record of these. If required, ...
Accessing and exploring large-scale genomics data sets remains a significant challenge to researchers without specialist bioinformatics training. We present the integrated PlantGenIE.org platform for exploration of Populus, conifer and Arabidopsis genomics data, which includes expression networks and associated visualization tools. Standard features of a model organism database are provided, including genome browsers, gene list annotation, BLAST homology searches and gene information pages. Community annotation updating is supported via integration of WebApollo. ...
The mouse genome database (MGD, http://www.informatics.jax.org/), the international community database for mouse, provides access to extensive integrated data on the genetics, genomics and biology of the laboratory mouse. The mouse is an excellent and unique animal surrogate for studying normal development and disease processes in humans. Thus, MGDs primary goals are to facilitate the use of mouse models for studying human disease and enable the development of translational research hypotheses based on comparative genotype, phenotype and functional analyses. Core MGD data content includes gene characterization and functions, phenotype and disease model descriptions, DNA and protein sequence data, polymorphisms, gene mapping data and genome coordinates, and comparative gene data focused on mammals. Data are integrated from diverse sources, ranging from major resource centers to individual investigator laboratories and the scientific literature, using a combination of automated processes and
Description== Leflunomide is a an isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. Source: [https://www.ncbi.nlm.nih.gov/mesh/2028012 MeSH] [[File:Screen Shot 2019-04-19 at 2.26.27 PM.png,frame,right, structure, image from PubChem]] ==Alternative names== ==Usage Notes== ==References== *[http://www.xenbase.org/literature/article.do?method=display&articleId=52355 Hatch et al 2016] *[https://pubchem.ncbi.nlm.nih.gov/compound/3899 NCBI PubChem CID:3899] > 4 Xenbase articles contain a reference to Leflunomide according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso] *[[Small Molecules for Xenopus Research,Back To Small Molecules Home Page ...
A program written by UCSC student Jim Kent, called GigAssembler, is used to periodically assemble a widely used public draft version of the human genome sequence using updated data from GenBank at the National Center For Biotechnology Information (NCBI). This assembly is steadily improving as the the public sequencing consortium churns out new data. We will look at the coverage statistics on the latest assembly, and then look at web tools to explore it, and what they find. The three most widely used public annotation browsers are the UCSC Genome browser (genome.ucsc.edu), the Ensembl genome browser (www.ensembl.org), and the NCBI map viewer (www.ncbi.nlm.nih.gov/genome/guide), the latter based on NCBIs own sequence assembly. We will focus on the UCSC browser, which shows a rich variety of data mapped to the genome sequence, including predicted genes, expressed sequence tags, full length mRNAs, genetic and radiation hybrid map markers, cytogenetically mapped clones, single nucleotide ...
Web Portal for International Cancer Research: Cancer Epidemiology and Genetic Databases, Research Programmes, Electronic Publications, Scientific Papers, IARC Press Releases, IARC Training Courses, IARC Fellowships for Cancer Research, IARC Meetings, etc
The Los Angeles Times reports that an Arizona crime lab technician found two felons with remarkably similar genetic profiles, so similar that they would ordinarily be accepted in court as a match, but one felon was black and the other white. The FBI estimated the odds of unrelated people sharing those genetic markers to be as remote as 1 in 113 billion. Dozens of similar matches have been found, and these findings raise questions about the accuracy of the FBIs DNA statistics. Scientists and legal experts want to test the accuracy of official statistics using the nearly 6 million profiles in CODIS, the national system that includes most state and local databases. The FBI has tried to block distribution of the Arizona results and is blocking people from performing similar searches using CODIS. A legal fight is brewing over whether the nations genetic databases ought to be opened to wider scrutiny. At stake is the credibility of the odds often cited in DNA cases, which can suggest an all but ...
topgo r topGO package provides tools for testing GO terms while accounting for the topology of the GO graph. org packages topGO. Asif D. Not required Entrez Gene IDs this example takes Ensembl Gene IDs and calcuates GO enrichment. I have a predefined list of the Ensembl gene IDs n 28 and I want to perform Gene Ontology using topGO in R. We used the R package topGO Alexa amp Rahnenf hrer 2009 to investigate the potential gene ontologies GO that were statistically enriched for the sets of genes identified among outliers and the Topgo Co. Alexa A Rahnenfuhrer J 2020 . Compare cash back offers. 886 2 2366 1346 Both PCA and k estimates were carried out in R v. It supports GO annotation from OrgDb object GMT file and user s own data. LEA . script. printTopGOresult . TopGO R package 45 was used for Gene Ontology enrichment analysis as well as DAVID 6. 2 years ago by al ash 20 lt prev 182 results page 1 of 8 next gt TopGo authors recommend 5 10 for more stable results 1 for no prune. 852 respectively . ...
Don Gilbert pointed out that cheap short sequencers are now available. Lots of people have inexpensive sequnces, but there still is no way to do cheap annotation. Current GMOD clients are species or family centered. Want to make it easy to integrate multiple species. ApiDB is at the point of opening new species databases and web sites with relatively little effort. Comparative genomics came up over and over again, both across species and within species. As data grows and is consolidated, issues of who owns the data and whos responsible for the annotation become more problematic. How does GMOD want to deal with integration issues? How close to the sequencer does GMOD want to get? We dont want to pull the data off the sequencer. Should we position GMOD as something that can feed data into places like Ensembl? Ensembl does not have curation expertise of the MODs. Even if NCBI is wonderful at consolidation, they wont have quality curation. GMOD sits right there, supporting curation. So, we doubt ...
RiceGE : Rice Functional Genomics Database. gebd Rice Genome Browser. iSect Tools, iView Tools and Gene Expression Atlas. Collection of Rice T-DNA/Ds, Rice cDNA, Marker, EST, MPSS, SAGE, Arabidopsis, Maize, Wheat, Barley Homology, Rice Tiling Array and Gene Expression Data. Created and developed by Huaming Chen
RiceGE : Rice Functional Genomics Database. gebd Rice Genome Browser. iSect Tools, iView Tools and Gene Expression Atlas. Collection of Rice T-DNA/Ds, Rice cDNA, Marker, EST, MPSS, SAGE, Arabidopsis, Maize, Wheat, Barley Homology, Rice Tiling Array and Gene Expression Data. Created and developed by Huaming Chen
Dear Pegah Tavakolkhah, , I have one more question. I have read in the description of some GOs , that they are involved in apoptosis or angiogenesis (which are the main , reasons of cancer). I wanted to know if apoptosis or angiogenesis are GO , themselves. And if they are, would their descendant GOs show the GOs , which are responsible for these two processes? If you do a search for terms either using GOOSE or using AmiGO (http://amigo.geneontology.org/), you can find the GO terms apoptosis (GO:0006915; http://amigo.geneontology.org/cgi-bin/amigo/term-details.cgi?term=GO:0006915) and angiogenesis (GO:0001525; http://amigo.geneontology.org/cgi-bin/amigo/term-details.cgi?term=GO:0001525). You can find the gene products that have been associated with these processes (and the more specific child processes), either by choosing the gene product associations link in AmiGO, or by using GOOSE to query the GO database. I hope that is helpful; if you have any more questions, please dont hesitate to ...
GO annotations: Mouse from MGI; Human from GO Annotations @ EBI (GOA); Rat from RGD; Chicken from GOA; Fly from FlyBase; Pfalc from PlasmoDB; Worm from WormBase; Dicty from dictyBase; Yeast from SGD; Zfin from ZFIN; Tair from TAIR/TIGR; Rice from Gramene; Pombe from Sanger GeneDB ...
Column 16 refers to a column in the Gene Ontologys (GO) tab-delimited gene association file (gaf) that WormBase submits to the GO consortium on a regular basis. Column 16 has been referred to as the Annotation Extension column in that it provides a placeholder for curation details that cannot be captured by a GO term alone, for example the substrate upon which an enzyme acts. A number of different types of information could conceivably be entered into Column 16. The list below begins to document the potential use of Column 16 by WormBase curators with any additional information or questions that have arisen during the course of curation. In the GAF, there will be an explicit relationship between the entity in Column 16 and the GO term. The annotation extension relations are viewable here: http://www.geneontology.org/scratch/xps/go_annotation_extension_relations.obo Column 16 curation at WormBase is just beginning and will likely be fleshed out more fully over the next few months. In the ...
Representation and depiction of phenotype information at SOC and HLT level. (A) We used the hierarchical information of the MedDRA ontology to map all phenotypi
FatiGO is a web-accessible application that functions in much the same way as DAVIDs GoCharts, including the ability to specify term-specificity level. Unlike DAVID, FatiGO does not allow the setting of a minimum hit threshold for simplified viewing of only the most highly represented functional categories. Likewise, FatiGO limits the graphical output to only one top-level GO category at a time, whereas DAVID allows the combined viewing of biological process, molecular function, and cellular component annotations simultaneously. FatiGOs static barchart output looks very similar to DAVIDs GoChart; an important distinction is that DAVIDs GoCharts are dynamic, allowing users to drill-down and traverse the GO hierarchy for any subset of genes, view the underlying chart data and associated annotations, and link out to external data repositories including LocusLink and QuickGO. As shown in Table 3 the majority of accession types accepted and functional annotations offered by DAVID are not ...
Description: This session displays a region of the LHX6 gene that highlights a selection of the new tracks added in the previous year for the hg38/GRCh38 human assembly. The tracks shown in this display (from top to bottom) include GENCODE Genes V22, transcription levels assayed across 9 ENCODE cell lines, DNase hypersensitive regions based on data from 95 ENCODE cell lines, genome-wide conservation scores calculated using phastCons, a multiple genome alignment created using Lastz and Multiz, and pathogenic CNVs from the ClinGen database. Adapted from Figure 1 in Speir, et al. The UCSC Genome Browser database: 2016 update. Nucleic Acids Res. 2016 Jan 4;44(D1):D717-25: http://nar.oxfordjournals.org/content/44/D1/D717. ...
Description: This session displays a region of the LHX6 gene that highlights a selection of the new tracks added in the previous year for the hg38/GRCh38 human assembly. The tracks shown in this display (from top to bottom) include GENCODE Genes V22, transcription levels assayed across 9 ENCODE cell lines, DNase hypersensitive regions based on data from 95 ENCODE cell lines, genome-wide conservation scores calculated using phastCons, a multiple genome alignment created using Lastz and Multiz, and pathogenic CNVs from the ClinGen database. Adapted from Figure 1 in Speir, et al. The UCSC Genome Browser database: 2016 update. Nucleic Acids Res. 2016 Jan 4;44(D1):D717-25: http://nar.oxfordjournals.org/content/44/D1/D717. ...
Developmental Anatomic Gene Expression Atlas (AGEA) The Allen Gene Expression Atlas (AGEA) for the Developing Mouse Brain is used to understand how voxels of the brain are related by gene expression (Correlation), and to find genes expressed at a particul
The comparability of gene expression data generated with different microarray platforms is still a matter of concern. Here we address the performance and the overlap in the detection of differentially expressed genes for five different microarray platforms in a challenging biological context where differences in gene expression are few and subtle. Gene expression profiles in the hippocampus of five wild-type and five transgenic δC-doublecortin-like kinase mice were evaluated with five microarray platforms: Applied Biosystems, Affymetrix, Agilent, Illumina, LGTC home-spotted arrays. Using a fixed false discovery rate of 10% we detected surprising differences between the number of differentially expressed genes per platform. Four genes were selected by ABI, 130 by Affymetrix, 3,051 by Agilent, 54 by Illumina, and 13 by LGTC. Two genes were found significantly differentially expressed by all platforms and the four genes identified by the ABI platform were found by at least three other platforms.
DEVELOPMENTAL ANATOMIC GENE EXPRESSION ATLAS (AGEA) AGEA is an interactive relational atlas based on spatial correlations of gene expression data for \2000 genes in the Allen Developing Mouse Brain Atlas. AGEA for the Developing Mouse Brain is used to und
The Ensembl human gene annotations have been updated using Ensembls automatic annotation pipeline. The updated annotation incorporates new protein and cDNA sequences which have become publicly available since the last GRCh37 genebuild (March 2009).. In release 67 (May 2012), we continue to display a joint gene set based on the merge between the automatic annotation from Ensembl and the manually curated annotation from Havana. This refined gene set corresponds to GENCODE release 12. The Consensus Coding Sequence (CCDS) identifiers have also been mapped to the annotations. More information about the CCDS project. Updated manual annotation from Havana is merged into the Ensembl annotation every release. Transcripts from the two annotation sources are merged if they share the same internal exon-intron boundaries (i.e. have identical splicing pattern) with slight differences in the terminal exons allowed. Importantly, all Havana transcripts are included in the final Ensembl/Havana merged (GENCODE) ...
Here at the Genome Browser were constantly looking for ways to improve the Browser and make it more accessible. A big part of that is making it as easy as possible for people to learn how to use our tools to best serve their research. In the past this has included setup and maintenance of documentation, including our help docs as well as a dedicated wiki site, where browser staffers and external users alike have shared content. We also continue to offer real-time support on our mailing list ([email protected]).. Thanks to funding support from the NHGRI we were recently able to amp up our training efforts in two ways. We now have a program whereby interested groups can economically host a Genome Browser workshop at their institution. For more information, fill out our intake survey: bit.ly/ucscTraining.. The other thing we have been able to do is launch a YouTube channel where you will find video tutorials explaining how to use various parts of the Browser. While static documents and email ...
TY - JOUR. T1 - ParkDB. T2 - A Parkinsons disease gene expression database. AU - Taccioli, Cristian. AU - Maselli, Vincenza. AU - Tegnér, Jesper. AU - Gomez-Cabrero, David. AU - Altobelli, Gioia. AU - Emmett, Warren. AU - Lescai, Francesco. AU - Gustincich, Stefano. AU - Stupka, Elia. N1 - Generated from Scopus record by KAUST IRTS on 2021-02-16. PY - 2011/12/1. Y1 - 2011/12/1. N2 - Parkinsons disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-Analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and ...
We investigate large functional genomics and high-throughput biological datasets. Assistance is provided in experimental design and subsequent analysis of next-generation sequencing, microarray, and mass-spectrometry-based proteomics experiments. The current focus is on the analysis of small RNA-Seq, mRNA-Seq and haploid ES cell screen data. Gene lists derived from publicly available studies or generated from in-house high-throughput experiments (NGS, microarray, proteomics) are analyzed for the overrepresentation of pathways, GO-terms, functional domains, or placed in interaction networks to visualize their relationships. Genome-wide expression patterns are contextualized with known processes and pathways using Gene Set Enrichment Analysis (GSEA). Local instances of integrated model organism databases and genome annotation portals permit visualization and analysis of in-house data with dedicated resources and additional privacy. User-driven data exploration is supported by the Ingenuity Pathway ...
We investigate large functional genomics and high-throughput biological datasets. Assistance is provided in experimental design and subsequent analysis of next-generation sequencing, microarray, and mass-spectrometry-based proteomics experiments. The current focus is on the analysis of small RNA-Seq, mRNA-Seq and haploid ES cell screen data. Gene lists derived from publicly available studies or generated from in-house high-throughput experiments (NGS, microarray, proteomics) are analyzed for the overrepresentation of pathways, GO-terms, functional domains, or placed in interaction networks to visualize their relationships. Genome-wide expression patterns are contextualized with known processes and pathways using Gene Set Enrichment Analysis (GSEA). Local instances of integrated model organism databases and genome annotation portals permit visualization and analysis of in-house data with dedicated resources and additional privacy. User-driven data exploration is supported by the Ingenuity Pathway ...
Allows to align query sequences against those present in a selected target database. BLAST is a suite of programs, provided by NCBI, which can be used to quickly search a sequence database for matches to a query sequence. The software provides an access point for these tools to perform sequence alignment on the web. The set of BLAST command-line applications is organized in a way that groups together similar types of searches in one application.
Strategies for discovering the genetic polymorphism responsible for an identified quantitative trait locus (QTL) generally follow two paths. One path involves generating additional experimental mapping populations to narrow an initial, wide QTL support interval [1]. For example, Yalcin et al. [2], used outbred mice and a QTL-knockout interaction test to identify Rgs2 as the gene underlying an anxiety phenotype. The other path involves making use of bioinformatic tools and archival data to better nominate candidate genes within a QTL support interval [3, 4]. For example, Flint and colleagues review and apply a hypothesis of human and mouse sequence conservation that may aid QTL gene or polymorphism discovery [5-7]. The combination of approaches should facilitate polymorphism identification, and more rapidly.. The BXD, an increasingly popular tool for mouse complex trait genetics, are a panel of recombinant inbred lines derived by inbreeding progeny from a C57BL/6J × DBA/2J F2 intercross [8]. ...
Cyclome: Arabidopsis Cyclome Functional Genomics Database. gebd Arabidopsis Genome Browser. iSect Tools, iView Tools and Gene Expression Atlas. Collection of Arabidopsis T-DNA/Ds, Full-length cDNA, Marker, EST, MPSS, SAGE, miRNA, sRNA, Arabidopsis Tiling Array and Gene Expression Data. Created and developed by Huaming Chen
Circadian rhythms of cell and organismal physiology are controlled by an autoregulatory transcription-translation feedback loop that regulates the expression of rhythmic genes in a tissue-specific manner. Recent studies have suggested that components of the circadian pacemaker, such as the Clock and …
#929394 - Construction of Decision Trees Based on Gene Expression Omnibus Data to Classify Bladder Cancer and Its Subtypes - Full View
This is the website for the Reed Labs Butterfly Genome Database at Cornell University.. This site provides a portal for searching and browsing high quality butterfly genome assemblies that are annotated with specialized data types including gene expression (e.g. RNA-seq), chromatin structure, and SNP variation. Data will be added on a rolling basis, and we encourage contributions from other research groups.. Blast: Search genome assemblies and gene predictions using Blast. Genome browser links are embedded in Blast result for your convenience.. Genome Browser: We use the UCSC genome browser as the most powerful current interface for manipulating and viewing complex data tracks. On this page you can go directly to any relevant coordinate in any genome we host.. Downloads: Download genome assemblies and accessory data tracks, as well as custom scripts from Reed Lab publications.. Citations: Publications to cite for specific data sets.. Please note that there are many additional lepidopteran ...
Web Portal for International Cancer Research: Cancer Epidemiology and Genetic Databases, Research Programmes, Electronic Publications, Scientific Papers, IARC Press Releases, IARC Training Courses, IARC Fellowships for Cancer Research, IARC Meetings, etc
Web Portal for International Cancer Research: Cancer Epidemiology and Genetic Databases, Research Programmes, Electronic Publications, Scientific Papers, IARC Press Releases, IARC Training Courses, IARC Fellowships for Cancer Research, IARC Meetings, etc
MaizeGDB is the maize research communitys central repository for genetic and genomic information about the crop plant and research model Zea mays ssp. mays. The MaizeGDB team endeavors to meet research needs as they evolve based on researcher feedback and guidance. Recent work has focused on better integrating existing data with sequence information as it becomes available for the B73, Mo17 and Palomero Toluqueño genomes. Major endeavors along these lines include the implementation of a genome browser to graphically represent genome sequences; implementation of POPcorn, a portal ancillary to MaizeGDB that offers access to independent maize projects and will allow BLAST similarity searches of participating projects data sets from a single point; and a joint MaizeGDB/PlantGDB project to involve the maize community in genome annotation. In addition to summarizing recent achievements and future plans, this article also discusses specific examples of community involvement in setting priorities and design
Bidirectional promoters are short (,1 kbp) intergenic regions of DNA between the 5 ends of the genes in a bidirectional gene pair.[14] A bidirectional gene pair refers to two adjacent genes coded on opposite strands, with their 5 ends oriented toward one another.[15] The two genes are often functionally related, and modification of their shared promoter region allows them to be co-regulated and thus co-expressed.[16] Bidirectional promoters are a common feature of mammalian genomes.[17] About 11% of human genes are bidirectionally paired.[14]. Bidirectionally paired genes in the Gene Ontology database shared at least one database-assigned functional category with their partners 47% of the time.[18] Microarray analysis has shown bidirectionally paired genes to be co-expressed to a higher degree than random genes or neighboring unidirectional genes.[14] Although co-expression does not necessarily indicate co-regulation, methylation of bidirectional promoter regions has been shown to ...
TY - JOUR. T1 - Editorial. T2 - Plant and cell physiologys 2016 online database issue. AU - Ohyanagi, Hajime. AU - Obayashi, Takeshi. AU - Yano, Kentaro. PY - 2016/1/1. Y1 - 2016/1/1. UR - http://www.scopus.com/inward/record.url?scp=84964900062&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84964900062&partnerID=8YFLogxK. U2 - 10.1093/pcp/pcv205. DO - 10.1093/pcp/pcv205. M3 - Review article. C2 - 26801748. AN - SCOPUS:84964900062. VL - 57. SP - 1. EP - 3. JO - Plant and Cell Physiology. JF - Plant and Cell Physiology. SN - 0032-0781. IS - 1. ER - ...
Update of /cvsroot/gmod/apollo/src/java/apollo/config In directory sc8-pr-cvs2.sourceforge.net:/tmp/cvs-serv30809 Modified Files: FeatureProperty.java TiersIO.java Added Files: ChadoJdbcNameAdapter.java Log Message: ChadoJdbcNameAdapter is based on ParameciumNameAdapter but more generic. This Name Adapter queries the database itself to generate new unique ids. It uses two parameters in the tiers config file : idPrefix : PTET chromosomeFormat : scaffold_(\d+) # To get the chromosome number The ParameciumNameAdapter should disapear... --- NEW FILE: ChadoJdbcNameAdapter.java --- package apollo.config; import org.apache.log4j.*; import apollo.datamodel.*; import apollo.editor.AddTransaction; import apollo.editor.CompoundTransaction; import apollo.editor.Transaction; import apollo.editor.TransactionManager; import apollo.editor.TransactionSubpart; import apollo.editor.UpdateTransaction; import java.io.BufferedReader; import java.io.InputStreamReader; import java.io.InputStream; import ...
Position Title: Research Associate (Senior Postdoc) / Research Associate (Postdoc) Working Title: Plant Ontology Project Coordinator How to Apply: -------------- To review the position description and apply, go to posting #0004322 at http://oregonstate.edu/jobs. When applying, you will be required to electronically submit your application, a cover letter citing your interest in the position and your experience, and a CV/resume including 3 references. Closing date 7/15/09. Position description: --------------------- The Plant Ontology Consortium (www.plantontology.org) is seeking applicants for a full-time position of scientific curator who will coordinate the Consortium s efforts. The Plant Ontology Consortium is a collaboration among researchers at Oregon State University, Cornell University and New York Botanical Garden. The Consortium also collaborates with the curators of many model organism databases including rice, Arabidopsis, maize, grasses, legumes, Solanaceae, bryophytes and plant ...
Bioinformatics is currently faced with very large-scale data sets that lead to computational jobs, especially sequence similarity searches, that can take absurdly long times to run. For example, the National Center for Biotechnology Information (NCBI) Basic Local Alignment Search Tool (BLAST and BLAST+) suite, which is by far the most widely used tool for rapid similarity searching among nucleic acid or amino acid sequences, is highly central processing unit (CPU) intensive. While the BLAST suite of programs perform searches very rapidly, they have the potential to be accelerated. In recent years, distributed computing environments have become more widely accessible and used due to the increasing availability of high-performance computing (HPC) systems. Therefore, simple solutions for data parallelization are needed to expedite BLAST and other sequence analysis tools. However, existing software for parallel sequence similarity searches often requires extensive computational experience and skill ...
Description: Beta cell genomics database provides searches and tools to explore detailed information about genes, transcripts, gene interactions, genomic regions, and beta cell related functional genomics studies. Institution: University of Pennsylvania Contacts: Beta Cell Biology Consortium Home Page: http://genomics.betacell.org/gbco/ ...
Genetic codes is a simple ASN.1 database hosted by the National Center for Biotechnology Information and listing all the known ... Genetic code Galperin, Michael Y; Cochrane Guy R (Jan 2011). "The 2011 Nucleic Acids Research Database Issue and the online ... Biological databases, Molecular genetics, Gene expression, Protein biosynthesis, All stub articles, Biological database stubs) ... Molecular Biology Database Collection". Nucleic Acids Res. England. 39 (Database issue): D1-6. doi:10.1093/nar/gkq1243. PMC ...
... (IGDD) is the first patient-based genetic disease database in India. It is developed and ... Genetic diseases and disorders, Biological databases, Databases in India, Diseases and disorders in India, Medical databases). ... This database keeps track of mutations in the causal genes for that genetic diseases common in India. The database will be ... "Indian genetic disease database". Nucleic Acids Res. England. 39 (Database issue): D933-8. doi:10.1093/nar/gkq1025. PMC 3013653 ...
Gypsy (GyDB) is a wiki-style database of mobile genetic elements. Classification of mobile genetic elements Horizontal gene ... "The Gypsy Database (GyDB) of mobile genetic elements: release 2.0". Nucleic Acids Res. England. 39 (Database issue): D70-4. doi ... Lloréns, C; Futami, R; Bezemer, D; Moya, A (January 2008). "The Gypsy Database (GyDB) of mobile genetic elements". Nucleic ... v t e (Articles with short description, Short description is different from Wikidata, Biological databases, Mobile genetic ...
35 (Database issue): D88-92. doi:10.1093/nar/gkl822. PMC 1716724. PMID 17130149. (Genetic mapping, Genome databases). ... A database of tissue-specific human enhancers is available through VISTA Enhancer Browser. GenomeVISTA allows the comparison of ... VISTA is a collection of databases, tools, and servers that permit extensive comparative genomics analyses. The VISTA family of ... not limited by the species collection already in the database) There are more than 28 searchable genomes, including vertebrate ...
Islander is a database of integrative islands in prokaryotic genomes. Mobile genetic elements Mantri, Yogita; Williams Kelly P ... Biological databases, All stub articles, Biological database stubs). ... Jan 2004). "Islander: a database of integrative islands in prokaryotic genomes, the associated integrases and their DNA site ... 32 (Database issue): D55-8. doi:10.1093/nar/gkh059. PMC 308793. PMID 14681358. http://www.indiana.edu/~islander #BrokenLink v t ...
Beltsville, Maryland: National Germplasm Resources Laboratory; USDA, ARS, National Genetic Resources Program. Archived from the ... "Compounds in deadly nightshade". Phytochemical and Ethnobotanical Databases. ...
"Variety Database". Avocadosource.com. Retrieved 2014-08-25. "MIA 19852 - Persea americana - Monroe". USDA, ARS, National ... Genetic Resources Program. Germplasm Resources Information Network - (GRIN). [Online Database] National Germplasm Resources ... "MIA 35743 - Persea americana - Monroe - Florida, United States". USDA, ARS, National Genetic Resources Program. Germplasm ... Resources Information Network - (GRIN). [Online Database] National Germplasm Resources Laboratory. 2002-08-29. Retrieved 2014- ...
"Cocaine content of plants". USDA, ARS, National Genetic Resources Program. Phytochemical and Ethnobotanical Databases. [Online ... "Atropine content of plants". USDA, ARS, National Genetic Resources Program. Phytochemical and Ethnobotanical Databases. [Online ... Database] National Germplasm Resources Laboratory, Beltsville, Maryland. Archived from the original on November 7, 2004. ... Database] National Germplasm Resources Laboratory, Beltsville, Maryland. Archived from the original on November 7, 2004. ...
"USDA, ARS, National Genetic Resources Program. Phytochemical and Ethnobotanical Databases. National Germplasm Resources ...
... the database concentrated on genetic information such as genetic linkage maps and other Mendalian information. SoyBase genetic ... SoyBase genetic linkage maps were integral to the assembly of the soybean genome. In 2018 the database received approximately ... SoyBase is a database created by the United States Department of Agriculture. It contains genetic information about soybeans. ... Results display soybean genetic (and genomic) data using Generic Model Organism Database (GMOD) open-source software. In ...
Barnes, Michael R. (2003). "Human Genetic Variation: Databases and Concepts". In Barnes, Michael R.; Gray, Ian C. (eds.). ... SNP-based genetic linkage analysis can be used to map disease loci, and determine disease susceptibility genes in individuals. ... The combination of SNP maps and high density SNP arrays allows SNPs to be used as markers for genetic diseases that have ... SNPs can also be used to study genetic abnormalities in cancer. For example, SNP arrays can be used to study loss of ...
DNA database § Privacy issues Genetic discrimination Genetic exceptionalism Gene theft Maryland v. King List of data breaches ... to make genetic inferences. As genetic databases grow at unprecedented rates, providing larger and more comprehensive ... ISBN 9781107076075 Genetic Information Privacy, EFF Medical and Genetic Privacy, ACLU Genetic Privacy Laws, NCSL (Articles with ... A study conducted in 2013 revealed vulnerabilities in the security of public databases that contain genetic data. As a result, ...
Check Hayden, Erika (2013). "Privacy loophole found in genetic databases". Nature. doi:10.1038/nature.2013.12237. S2CID ... Genetic non-discrimination laws have been enacted in some US states and at the federal level, by the Genetic Information ... genetic genealogy and public-records databases." This has led to calls for policy-makers to establish consistent guidelines and ... Hiding or perplexing genetic information by a computational method Elective genetic and genomic testing "NCI Dictionary of ...
"CGD Help: Non-standard Genetic Codes". Candida Genome Database. Retrieved 1 May 2015. Santos, Manuel A. S.; Ueda, Takuya; ... Watanabe, Kimitsuna; Tuite, Mick F. (31 October 2003). "The non-standard genetic code of Candida spp.: an evolving genetic code ... This novel genetic code may be a mechanism for more rapid adaptation to the organism's environment, as well as playing an ... 2015). Some species of Candida use a non-standard genetic code in the translation of their nuclear genes into the amino acid ...
... databases Database for B thalassemia in Arabs Israeli National genetic bank contains genetic mutations of Arabs Teebi database ... "CTGA: The Database for Genetic Disorders in Arabs" (PDF). Archived from the original (PDF) on 8 March 2014. "Genetic Diseases ... DNA history of Egypt Genetic history of the Middle East Genetic history of North Africa Genetic studies on Jews Genetic studies ... database for genetic disorders in Arab populations. At present, the CTGA database is centrally maintained in Dubai, and hosts ...
Tyers M. "BioGRID - Database of Protein, Chemical, and Genetic Interactions". thebiogrid.org. Subotić A, Swinnen E, Demuyser L ... Non-standard Genetic Codes". Candida Genome Database. Retrieved 30 October 2011. Andrzej (Anjay) Elzanowski and Jim Ostell (7 ... Candida Genome Database U.S. National Institutes of Health on the Candida albicans genome Mycobank data on Candida albicans ... This is an unusual example of a departure from the standard genetic code, and most such departures are in start codons or, for ...
Genetic Resources and Crop Evolution. 59 (5): 655-681. doi:10.1007/s10722-011-9709-2. S2CID 14101302. "USDA Plants Database". v ...
Richard contributed guitar to the soundtrack of the 2008 film Repo! The Genetic Opera. Richard is friends with Lacey Mosley, ... "I Melt With You" (2011): Soundtracks". Internet Movie Database. "Birthday: Richard Patrick". "Richard Patrick: Why I Quit Nine ...
"Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis". Ann Rheum Dis. 67 ( ... The PDGene Database. The Michael J. Fox Foundation for Parkinson's Research. Archived from the original on 2011-07-27. ... neuropsychological and molecular-genetic study". NOVA Science: 70-87.{{cite journal}}: CS1 maint: multiple names: authors list ... "Replication validity of genetic association studies". Nature Genetics. 29 (3): 306-309. doi:10.1038/ng749. PMID 11600885. S2CID ...
Retrieved 2009-01-20.[permanent dead link] "Detailed information for cultivar: Germaine". Seed and Plant Genetic Resources ... ISBN 2-84038-635-6. "Cultivar name: Germaine". OLEA Databases. Retrieved 2009-01-20. "Germaine" (PDF). International Olive ...
"Detailed information for cultivar: Bosana". Seed and Plant Genetic Resources Service - AGPS. 2005. Retrieved 2009-01-13. (CS1 ... "Cultivar name: Bosana". OLEA Databases. Retrieved 2009-01-14. "Bosana" (PDF) (in Spanish). International Olive Council. ... "Agronomical characters for cultivar Bosana". OLEA Databases. Retrieved 2009-01-14. " ...
Genetic algorithms. Ensemble calculations of numerical weather prediction. Event simulation and reconstruction in particle ... BLAST searches in bioinformatics with split databases. Large scale facial recognition systems that compare thousands of ... Mathog, DR (22 September 2003). "Parallel BLAST on split databases". Bioinformatics. 19 (14): 1865-6. doi:10.1093/ ... Monte Carlo analysis Distributed relational database queries using distributed set processing. Numerical integration Serving ...
Genetic data has been accumulated in databases. Researchers are able to utilize algorithms to decipher the data accessible from ... As large quantities of genomic sequence data began to accumulate in public databases, genetic algorithms became important to ... The following are databases and tools: GenBank database provides genomic datasets for analysis. UCSC Genome Browser AntiSMASH- ... BIG-FAM is a biosynthetic gene cluster family database. DoBISCUIT is a database of secondary metabolite biosynthetic gene ...
List of all genetic codes: translation tables 1 to 16, and 21 to 31. The genetic codes database. This article incorporates text ... The Condylostoma nuclear code (translation table 28) is a genetic code used by the nuclear genome of the heterotrich ciliate ... Elzanowski A, Ostell J, Leipe D, Soussov V. "The Genetic Codes". Taxonomy browser. National Center for Biotechnology ... "Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum ...
EAAP Animal Genetic Database. Retrieved 27 April 2016. Kohl, Wilhelm; Toth, Peter (2014). The Mangalitsa Pig: Royalty is Coming ...
List of all genetic codes: translation tables 1 to 16, and 21 to 33. The genetic codes database. This article incorporates text ... The Blastocrithidia nuclear code (translation table 31) is a genetic code used by the nuclear genome of the trypanosomatid ... Elzanowski A, Ostell J, Leipe D, Soussov V. "The Genetic Codes". Taxonomy browser. National Center for Biotechnology ... "An Unprecedented Non-canonical Nuclear Genetic Code with All Three Termination Codons Reassigned as Sense Codons". Current ...
List of all genetic codes: translation tables 1 to 16, and 21 to 31. The genetic codes database. This article incorporates text ... The peritrich nuclear code (translation table 30) is a genetic code used by the nuclear genome of the peritrich ciliates ... Elzanowski A, Ostell J, Leipe D, Soussov V. "The Genetic Codes". Taxonomy browser. National Center for Biotechnology ... Sánchez-Silva, Rocı́o; Villalobo, Eduardo; Morin, Loı̈c; Torres, Antonio (2003). "A New Noncanonical Nuclear Genetic Code". ...
Cowrie Genetic Database Project. 2005. Media related to Ransoniella punctata at Wikimedia Commons (Articles with short ...
List of all genetic codes: translation tables 1 to 16, and 21 to 31. The genetic codes database. This article incorporates text ... The karyorelictid nuclear code (translation table 27) is a genetic code used by the nuclear genome of the Karyorelictea ciliate ... Elzanowski A, Ostell J, Leipe D, Soussov V. "The Genetic Codes". Taxonomy browser. National Center for Biotechnology ... Swart, Estienne Carl; Serra, Valentina; Petroni, Giulio; Nowacki, Mariusz (2016). "Genetic Codes with No Dedicated Stop Codon: ...
"BioGRID , Database of Protein, Chemical, and Genetic Interactions". thebiogrid.org. Retrieved 2017-05-07. Database, GeneCards ... "GeneCards - Human Genes , Gene Database , Gene Search". www.genecards.org. Retrieved 2017-05-07. Database, GeneCards Human Gene ... "HGNC database of human gene names , HUGO Gene Nomenclature Committee". www.genenames.org. Retrieved 2017-05-07. "Home - UniGene ... Database, GeneCards Human Gene. "TBX4 Gene - GeneCards , TBX4 Protein , TBX4 Antibody". www.genecards.org. Retrieved 2017-05-09 ...
"Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer". cgap.nci.nih.gov. Retrieved 2018-11-27. Nathanson, ... "Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity". Nature. 543 (7643): 122-125. ... ". "Faculty Database Production Server , David Geffen School of Medicine at UCLA". people.healthsciences.ucla.edu. Retrieved ...
Databases and computational tools for mimotopes have been an important part of phage display study. Databases, programs and web ... Many genetic sequences are expressed in a bacteriophage library in the form of fusions with the bacteriophage coat protein, so ... Huang J, Ru B, Zhu P, Nie F, Yang J, Wang X, Dai P, Lin H, Guo FB, Rao N (January 2012). "MimoDB 2.0: a mimotope database and ... 40 (Database issue): D271-7. doi:10.1093/nar/gkr922. PMC 3245166. PMID 22053087. Negi SS, Braun W (2009). "Automated Detection ...
When the endemic E. minor population declined in New Zealand, it left a genetic opening for E. novaehollandiae. The decrease of ... not intended to be a complete database of the birds of New Zealand). TerraNature New Zealand native birds list. (Articles with ...
Genetic factors also contribute to cervical cancer risk. Cervical cancer typically develops from precancerous changes over 10 ... The Cochrane Database of Systematic Reviews. 2021 (9): CD002834. doi:10.1002/14651858.CD002834.pub3. ISSN 1469-493X. PMC ... The Cochrane Database of Systematic Reviews. 2022 (3): CD008239. doi:10.1002/14651858.CD008239.pub5. ISSN 1469-493X. PMC ... The Cochrane Database of Systematic Reviews. 5 (5): CD007583. doi:10.1002/14651858.cd007583.pub3. PMC 4171000. PMID 22592722. ...
Whitworth, M; Bricker, L; Mullan, C (2015). "Ultrasound for fetal assessment in early pregnancy". Cochrane Database of ... the ISUOG recommends that pregnant patients who desire genetic testing have obstetric ultrasounds between 11 weeks' and 13 ...
Vinjé J, Green J, Lewis DC, Gallimore CI, Brown DW, Koopmans MP (2000). "Genetic polymorphism across regions of the three open ... In: ICTVdB-The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA "2011 ICTV ... Norovirus (vomiting bug) NHS Norovirus infections Global network and database noroviruses CDC Viral Gastroenteritis FAQs: ... which can be further divided into different genetic clusters or genotypes. Noroviruses commonly isolated in cases of acute ...
... movie and game database company acquired by RhythmOne Afghanistan Mission Network, a coalition network for NATO led missions in ... a rare X-linked genetic disease AMN (TV station), in Griffith, New South Wales, Australia Access Media Network, a ...
GENSCAN was shown to exactly predict exon location with 90% accuracy with 80% specificity compared to an annotated database. ... and in particular genetic information. They have since become an important tool in the probabilistic modeling of genomic ...
An example of a PFM from the TRANSFAC database for the transcription factor AP-1: The first column specifies the position, the ... and genetic diversity. Curr Protoc Protein Sci. Vol. chapter 2. pp. 2.12.1-2.12.14. doi:10.1002/0471140864.ps0212s48. ISBN 978- ... A similar approach is commonly used by modern protein domain databases such as Pfam: human curators would select a pool of ... Within a sequence or database of sequences, researchers search and find motifs using computer-based techniques of sequence ...
cite book}}: ,first2= has generic name (help) "Yeast Species Database". Retrieved 2010-12-24. S. Zaragoza; L. Galanternik; M. ... Different strains, it was suggested, should also be studied "to increase knowledge of genetic diversity and antifungal ...
Through genetic engineering, Calgene hoped to slow down the ripening process of the tomato and thus prevent it from softening ... "GM Crop Database:Tomato". International Life Sciences Institute. Archived from the original on July 25, 2011.{{cite web}}: CS1 ... The harmful, parasitic genetic material was removed from the bacterial T-plasmid and was replaced by the favored genes. The ... Because some members of the public were misinformed on genetic technology, people feared the Flavr Savr and other genetically ...
The explanation was that the simo-leap with Al had left Sam with enough of Al's genetic coding that he could leap back past his ... with access to vast historical databases, the project's funds were running thin. Eager to prove his theories, Sam prematurely ... In the fifth-season episode "Trilogy (Part 2)," Sam fathers a child who proves to be his true genetic child, not the child of ... the explanation was that Sam's close genetic link with his ancestor allowed him to do this. This was also partly due to an " ...
A sample of encapsulated inments from a close genetic relative of H. salinarum is estimated to be 121 million years old[ ... Kozlowski, LP (26 October 2016). "Proteome-pI: proteome isoelectric point database". Nucleic Acids Research. 45 (D1): D1112- ... Scientists have previously recovered similar genetic material from the Michigan Basin,[clarification needed] the same region ...
Databases Flow Chart of Metabolic Pathways at ExPASy IUBMB-Nicholson Metabolic Pathways Chart SuperCYP: Database for Drug- ... These genetic modifications usually aim to reduce the amount of energy used to produce the product, increase yields and reduce ... Database of biological pathways KEGG - Collection of bioinformatics databases Friedrich C (1998). Physiology and genetics of ... Nucleic acids are critical for the storage and use of genetic information, and its interpretation through the processes of ...
Jeroen Baas; Boyack, Kevin; Ioannidis, John P. A. (2021). "August 2021 data-update for "Updated science-wide author databases ... due to genetic drift as well as environmental and dietary factors. This is often misdiagnosed until the disease has become ... Elsevier published a list of the top cited scientists from 22 different fields based on the Scopus database. In the field of ...
The first imprinted genetic disorders to be described in humans were the reciprocally inherited Prader-Willi syndrome and ... geneimprint.com Imprinted Gene and Parent-of-origin Effect Database J. Kimball's Imprinted Genes Site Genomic+imprinting at the ... A hypothesis for the origin of this genetic variation states that the host-defense system responsible for silencing foreign DNA ... It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. These ...
A genetic study published in 2017 showed that the Burmese pythons in Florida are hybrids with P. molurus. In the literature, ... Python molurus at the Reptarium.cz Reptile Database. Accessed 13 September 2007. Indian Python at Ecology Asia. Accessed 13 ...
Animal Genome Size Database Plant DNA C-values Database Fungal Genome Size Database Fungal Database Archived 2008-03-10 at the ... As much as 90% of the genetic material can be lost when a species makes the evolutionary transition from a free-living to an ... Animal Genome Size Database Bacterial genome size C-value Cell nucleus Comparative genomics Comparison of different genome ... This process seems to be dominated by genetic drift resulting from small population size, low recombination rates, and high ...
Furthermore, plants in cultivation are likely to come from a limited genetic pool. With under 2% of its original extent ... IBIS database. Canberra, Australian Capital Territory: Centre for Plant Biodiversity Research, Australian Government. Retrieved ... Species Profile and Threats Database. Canberra, Australian Capital Territory: Commonwealth of Australia. Retrieved 14 December ...
37 (Database issue): D852-7. doi:10.1093/nar/gkn732. PMC 2686605. PMID 18996892. Xu GP, Zhang ZL, Xiao S, Zhuang LK, Xia D, Zou ... However, virus-encoded genetic elements have the ability to antagonize the IFN response contributing to viral pathogenesis and ... A collection of known ISGs is available on Interferome, a curated online database of ISGs (www.interferome.org); Additionally, ... Samarajiwa SA, Forster S, Auchettl K, Hertzog PJ (January 2009). "INTERFEROME: the database of interferon regulated genes". ...
... in AcademiaNet, a database of scientists in Germany Cornelia Ulrich at Huntsman Cancer Institute DKFZ Executive ... and genetic testing." (Mentors: John D. Potter, Stephen Schwartz) 1991/92: Fulbright Scholarship and Fulbright Professional ... "Association of aspirin and non-steroidal anti-inflammatory drug use with risk of colorectal cancer according to genetic ...
also showed that UV-irradiation increased the frequency of recombination due to genetic exchange in S. acidocaldarius. Frols et ... "GTDB release 05-RS95". Genome Taxonomy Database. Parks, DH; Chuvochina, M; Chaumeil, PA; Rinke, C; Mussig, AJ; Hugenholtz, P ( ... All-Species Living Tree Project."16S rRNA-based LTP release 132". Silva Comprehensive Ribosomal RNA Database. Retrieved 2015-08 ... Wood ER; Ghané F; Grogan DW (September 1997). "Genetic responses of the thermophilic archaeon Sulfolobus acidocaldarius to ...
Cross-Disorder Group of the Psychiatric Genomics Consortium; Genetic Risk Outcome of Psychosis (GROUP) Consortium (2013). " ... 116 colorectal carcinoma cells after transfection of miR-137 with the list of predicted miR-137 targets via miRecords database ...
Anya Volkova - Former League of Assassins, she collected a database about the members of the league which was stolen by the ... Respawn - A clone created with the genetic material of Deathstroke and Talia al Ghul. After escaping torture and captivity at ...
The Europeana databases use it, and for instance on the Wikimedia Commons in February 2016 2.9 million works (~10% of all works ... Intergovernmental Committee on Intellectual Property and Genetic Resources, Traditional Knowledge and Folklore: Seventeenth ... brought a suit against Wikimedia Commons in 2016 for photographs uploaded to the database depicting pieces of art in the museum ...
Internet Movie Database. Retrieved January 25, 2010. "'Extraordinary Measures,' filmed in Portland and starring Brendan Fraser ... a genetic anomaly that typically kills most children before their tenth birthdays. John, an advertising executive, contacts ...
Retrieved 29 March 2009.old-form url Database entry includes a brief justification of why this species is of near threatened. ... but also from problems associated with small populations such as lack of genetic diversity in the population, which makes them ...
... at Wookieepedia Dark Empire I at the Grand Comics Database Dark Empire I at the Comic Book DB (archived from the ... The physician had deliberately inserted genetic material and contaminants into all stored samples of the Emperor's original ... Empire's End at the Grand Comics Database Empire's End at the Comic Book DB (archived from the original) (Use mdy dates from ... unless he can either fix his genetic material (an impossibility since no unaltered samples remain) or insert his spirit into ...
Other databases (e.g. Ensembl) rely on curated data sources as well as a range of different software tools in their automated ... Identifying the locations of genes and other genetic control elements is often described as defining the biological "parts list ... 41 (Database issue): D536-44. doi:10.1093/nar/gks1080. PMC 3531119. PMID 23161684. Stein, L. (2001). "Genome annotation: from ... Some databases use genome context information, similarity scores, experimental data, and integrations of other resources to ...
Genetic analysis has proved that the steelhead trout (Oncorhyncus mykiss) that spawn and rear in the Petaluma River watershed ... "National Bridge Inventory Database". Wikimedia Commons has media related to Adobe Creek (Sonoma County, California). United ...
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q ... Understanding the genetic evolution of A [‎H1N1]‎pdm09 and H3N2 viruses can help better select strains to be included in the ...
Understanding the genetic evolution of A [‎H1N1]‎pdm09 and H3N2 viruses can help better select strains to be included in the ...
Patent searches for genetic sequences: How to retrieve relevant records from patented sequence databases. *Guillaume Dufresne1 ... Being sequentially derived from the latter type of database, their formats are similar. Thus, database search tools such as ... Databases of patented sequences, such as the public database PAT1 (the patent sequences division of GenBank) and the ... Ouellette, B.F. & Boguski, M.S. Database divisions and homology search files: a guide for the perplexed. Genome Res. 10, 952- ...
... private genetic databases, Professor Erin Murphy, rape kit, rights, totally reasonable steps by law enforcement, Transparency, ... Paying To Add Your DNA To a Government Database via Ancestry.com and 23andMe October 31, 2015. October 31, 2015. Kelly W. ... database, Dishonesty, DNA, eff, Electronic Frontier Foundation, FBI, filmmaker, freedom, Fusion.net, genealogy, government ... funded DNA databases, Harassment, Illegal search/entry, Justice System, kelly patterson, Michael Usry, murder, new orleans, New ...
... then subject them to a fast and relatively inexpensive genetic analysis. That data, he suggested, would go into a database that ...
Gathering genetic information is important for law enforcement authorities currently engaged in criminal investigations, or for ... "Without external checks on the Ministry of Public Securitys power, police in Tibet will be free to use a mass DNA database for ... badscience, big government, biotechnology, CCP, China, communism, conspiracy, DNA harvesting, enslaved, fascism, genetic lunacy ... "Chinas collection of genetic samples without consent violates Tibetan rights under international law and strengthens its ...
After updating and integrating EPDs and genetic indicators for ... as one of the newest affiliates of International Genetic ... American Salers Association joins IGS genetic evaluation database. News News , Jul 28, 2020. ... The American Salers Association recently entered as one of the newest affiliates of International Genetic Solutions (IGS). ... Cumulatively, they have put together the most directly-comparable, multi-breed genetic evaluation tool available. ...
Genetic dissection of Iddm26 in the spontaneously diabetic BBDP rat.. Authors:. Sarmiento, J Wallis, RH Ning, T Marandi, L Chao ... Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) ...
Search our database for the contact details of organizations that directly address Genetic Engineering ... Search our database for the contact details of organizations that directly address Genetic Engineering ... Genetic Engineering. What are Genetically Modified Organisms (GMOs)?. Humans have manipulated nature for thousands of years but ... Most genetic engineering has so far been with crops, which have been modified to either withstand herbicides or produce their ...
The purpose of this study is to establish a patient and clinical information database, and a genetic material biobank to better ... A Study to Establish a Patient Clinical and Genetic Information Database to Better Characterize Symptoms and Causes of Angelman ...
Genetic monitoring of supportive breeding in brown trout ( Salmo trutta L.), using microsatellite DNA markers. In: Canadian ... Genetic monitoring of supportive breeding in brown trout ( Salmo trutta L.), using microsatellite DNA markers. Canadian Journal ... Hansen, M. M., Eg Nielsen, E., Ruzzante, D. E., Bouza, C., & Mensberg, K-L. D. (2000). Genetic monitoring of supportive ... Genetic monitoring of supportive breeding in brown trout ( Salmo trutta L.), using microsatellite DNA markers. / Hansen, ...
The bipolar disorder phenome database: A resource for genetic studies. American Journal of Psychiatry. 2007 Aug;164(8):1229- ... The bipolar disorder phenome database: A resource for genetic studies. James Bennett Potash, Jennifer Toolan, Jo Steele, Erin B ... The bipolar disorder phenome database : A resource for genetic studies. In: American Journal of Psychiatry. 2007 ; Vol. 164, No ... Dive into the research topics of The bipolar disorder phenome database: A resource for genetic studies. Together they form a ...
... genetic modification is a priority. In this chapter, we describe a range of genetic techniques that can be used for M. neoaurum ... genetic modification is a priority. In this chapter, we describe a range of genetic techniques that can be used for M. neoaurum ... genetic modification is a priority. In this chapter, we describe a range of genetic techniques that can be used for M. neoaurum ... genetic modification is a priority. In this chapter, we describe a range of genetic techniques that can be used for M. neoaurum ...
Retinal and hearing impairment genetic mutation database. myosin VIIA (MYO7A) LOVD v.2.0 Build 37 [ Current LOVD status ]. Log ... Full database search. Variant listing based on patient origin. Database statistics. Switch gene. ... MYO7A DB-ID: Database IDentifier; When available, links to OMIM IDs are provided. Patient ID: Internal reference to the ... WARNING: This database is no longer updated. Please visit LOVD3 shared for the current install. ...
The value of mutation databases for public health assessment also is limited by the rarity of genetic laboratory confirmation ... Evaluation of Genetic Tests. In 1999, the National Institutes of Health (NIH)-U.S. Department of Energy Task Force on Genetic ... Genetic Tests and PI Diseases. Advances in molecular biology and genetic technology have facilitated localization of disease ... genetic testing examining a sample of blood or other body fluid or tissue for biochemical, chromosomal, or genetic markers that ...
Results of search for ccl=su:{Databases} and su-to:Genetic Counseling ... Online Database IRIS GIFT HINARI PubMed Global Health Library AFRO (AIM) EMRO (IMEMR) PAHO (LILACS) SEARO (IMSEAR) WIPRO (WPRIM ... Genetic Screening : Ethical Issues. by Nuffield Council on Bioethics.. Material type: Text; Format: print ; Literary form: Not ...
Cystis Fibrosis Mutation Database. Cystic Fibrosis Genetic Analysis Consortium. Available at http://www.genet.sickkids.on.ca/ ... Genetic testing for cystic fibrosis. National Institutes of Health Consensus Development Conference Statement on genetic ... Additional genetic modifiers include a 129/Sv allelic contribution in mice that yields a milder inflammatory response in CF and ... Whether this is genetic or due to socioeconomic factors is unclear; low socioeconomic status is associated with significantly ...
Correlation of genetic and microbial changes in inflammatory bowel disease. Other Titles: İnflamatuvar bağırsak hastalığında ... Terlemez, G. (2021). Correlation of genetic and microbial changes in inflammatory bowel disease. Unpublished masters thesis, ...
Before using at-home genetic testing, find out how the company will protect your information. Find questions to help assess a ... How does the company safeguard your genetic data and other personal information that you provide? Is it stored in a database ... What do the results of direct-to-consumer genetic testing mean?. *What can raw data from a direct-to-consumer genetic test tell ... How is direct-to-consumer genetic testing done?. *How much does direct-to-consumer genetic testing cost, and is it covered by ...
Maryland and Montana Pass the Nations First Laws Restricting Law Enforcement Access to Genetic Genealogy Databases. ... New York introduced legislation that would do away with local DNA databases altogether. San Franciscos latest problems with ... Even if police and prosecutors in San Francisco decide to limit the DNA included in the local crime lab database, this wont ... None of this DNA can legally be entered into state or federal DNA databases-it can only be collected and then repeatedly ...
Of the 50 mutants with an epidermal phenotype, 9 map to human genetic conditions with skin abnormalities. Some mutant genes are ... Reactome: a database of reactions, pathways and biological processes. Nucleic Acids Res. 39, D691-D697 (2011). ... How to cite this article: Liakath-Ali, K. et al. Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. ... a) Coat colour of WT and Myo5a−/− mice on a BL6 genetic background. (b) Stack bar graphs shows coat colour and epidermal ...
Basic Genetic Modification. Gene Introduced. Gene Source. Product. Function. cry1Ab Bacillus thuringiensis subsp. kurstaki. ... The GM Approval Database, or GMAD, is one of ISAAAs unique features that compiles all the available information about biotech/ ... Biosafety Clearing Houses and peer-reviewed scholarly articles to maintain the credibility of the database. Your contribution ...
Databases; DNA; Deoxyribonucleic acids; Neoplasms; Genetic factors ... By performing a meta-analysis of transcriptional age signature across multi-tissues using the GTEx database, we identify 1,616 ... mortality risk and cancer stage in several types of cancer from the TCGA database, and offers complementary information to DNA ...
A user-friendly database of genetic dependencies in cancer A major challenge in cancer therapeutics is to kill tumour cells ... The Human Metabolome Database (HMDB) is a freely available database that contains detailed information about small molecules ... Cystinosis is a genetic disorder due to a gene defect called cystinosin, where a toxic metabolite called cysteine collects in ... The most severe form of this genetic disorder, where people carry two bad AAT genes (Z) is known as ZZ-AATD and this affects ...
In a Cochrane Database study, the combination of BRAF plus MEK inhibitors was found to be the best treatment option, followed ... Clinical Implications and Genetic Testing. First-line treatment of patients with BRAF V600 wild-type or mutation-positive, ... Cochrane Database Syst Rev. 2018 Feb 6. 2:CD011123. [QxMD MEDLINE Link]. ... physicians in private practice who do not routinely process specimens for genetic testing might find that waiting for a ...
Spain to establish national genetic database. *Xavier Bosch. *Full-Text HTML. *PDF ...
... issues related to genetic testing for prostate cancer risk. ... The genetic profiling results were given to the men alongside ... The men used the results of their genetic tests to talk to others and this is important as it can help genetic information to ... Most of them understood the limitations of genetic testing. *Some men were concerned that genetic testing could worry people ... The researchers say that genetic testing is complicated as cancer risk is a combination of both genetic and environmental ...
  • Thus, database search tools such as BLAST 3 and FASTA 4 , which are designed to locate biologically relevant sequences, are also usually used to assess the intellectual property content 5 of genes. (nature.com)
  • Although most of the genes that have been identified are associated with rare genetic disorders, genes that confer susceptibility to common diseases such as cancer, heart disease, and diabetes are also being discovered. (cdc.gov)
  • By performing a meta-analysis of transcriptional age signature across multi-tissues using the GTEx database, we identify 1,616 common age-related genes, as well as tissue-specific age-related genes. (cdc.gov)
  • A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (senescence.info)
  • A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
  • Database of human genes associated with cellular senescence. (senescence.info)
  • The 1,000 individuals were screened for variants in 114 genes selected by an expert panel for their association with medically actionable genetic conditions possibly undiagnosed in adults. (nih.gov)
  • Genetics is the study of genes , heredity , and the variation of organisms , as well as the medical practice of diagnosing, treating, and counseling patients with genetic disorders . (wikipedia.org)
  • To read these genes, researchers use primers-short, manufactured DNA pieces that complement segments of DNA found in a species' genome and serve as anchor points to start genetic sequencing. (mbari.org)
  • Such genes might be also investigated in terms of association with CAD by performing a genome wide association study using the UK Biobank database and the repository of gene variants, (single nucleotype polymorphisms , SNP), excluding those genes related to the common risk factors. (ukbiobank.ac.uk)
  • More, the function of the identified genes can be investigated using the large database of phenotypic data (clinical and biochemical) in carriers of the one or two copies of the gene variants (SNP) under investigation. (ukbiobank.ac.uk)
  • Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
  • Databases devoted to knowledge about specific genes and gene products. (bvsalud.org)
  • Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli. (ebi.ac.uk)
  • Among the 1,000 participants, 585 instances of 239 unique variants were identified as disease causing in the Human Gene Mutation Database (HGMD). (nih.gov)
  • Cystis Fibrosis Mutation Database. (medscape.com)
  • Method: Participants were ascertained for two bipolar disorder genetic linkage studies: the University of Chicago, Johns Hopkins, and National Institute of Mental Health (NIMH) Intramural Program (CHIP) Collaboration and the NIMH Genetics Initiative project. (elsevier.com)
  • Researchers and clinicians can use this database to explore the connections between phenomenology and genetics in a cohort that is adequately powered to detect even modest genetic effects in bipolar disorder. (elsevier.com)
  • A newly published paper in Genetics in Medicine has reinforced the fundamental importance of collecting information about genetic variances in a single large database. (sinaihealth.ca)
  • The investigators and participants of the Canadian Open Genetics Repository have also partnered with numerous international organizations to connect their database with other data sharing initiatives to make it public and available to the broader community of researchers, patients and clinicians. (sinaihealth.ca)
  • But surprisingly, molecular genetics has discovered that all organisms are equivalent to each other in their basic genetic structures. (hstalks.com)
  • In modern research, genetics provides important tools in the investigation of the function of a particular gene, e.g. analysis of genetic interactions . (wikipedia.org)
  • Ongoing work includes integration of information to allow navigation via comparative genomics from genetics loci to chromosome, and development of crop genetics databases. (edu.au)
  • Databases of patented sequences, such as the public database PAT 1 (the patent sequences division of GenBank) and the proprietary database GENESEQ 2 (provided by Derwent Thomson Scientific), are updated repositories that can be used to run patent searches. (nature.com)
  • Apart from ancillary annotation, patented sequence databases comprise the same type of information-DNA and polypeptide sequences-as primary DNA and protein databases 1 such as EMBL, GenBank, and DDBJ. (nature.com)
  • NEW YORK - Embleema said on Thursday that it has received a $2 million contract from the US Food and Drug Administration to help advance the agency's Database for Reference Grade Microbial Sequences (FDA-ARGOS) for combating infectious diseases. (genomeweb.com)
  • On this occasion, Kovalchuk said during the events of the first Russian forum of the wine industry: "During the year, the specialists of our center were able to decipher the genetic sequences of more than 200 grape varieties, and now we have the largest grape genetic database in the world. (asumetech.com)
  • Geneticist sequences own genome, finds genetic cause of his disease If you've got an inherited disease and you want to find the genetic faults responsible, it certainly helps if you're a prominent geneticist. (scienceblogs.com)
  • Genetic diversity at its most elementary level is represented by differences in the sequences of nucleotides (adenine, cytosine, guanine, and thymine) that form the DNA (deoxyribonucleic acid) within the cells of the organism. (hstalks.com)
  • The team created the most complete library of DNA sequences from comb jellies, adding 72 species to the global database where only 15 had been represented before. (mbari.org)
  • CDC performs genome sequencing to compare the genetic sequences of vaccine viruses with those of circulating viruses. (cdc.gov)
  • A database was created from previously published mtDNA HVS I sequences (representing 2,615 individuals from different Asian and European populations) and 74 modern Hungarian sequences from the present study. (blogspot.com)
  • The data may be either a list of database accession numbers, NCBI gi numbers, or sequences in FASTA format. (nih.gov)
  • No BLAST database contains all the sequences at NCBI. (nih.gov)
  • The search will be restricted to the sequences in the database that correspond to your subset. (nih.gov)
  • The large amount of genetic information accumulated in the post-genomic era needs to be transformed into knowledge 1 . (nature.com)
  • Clearly, in order for personal genomic tests to make any difference in improving health, we need to conduct additional research on the benefits and harms of genetic tests in the same way we collect research data about other types of health information. (cdc.gov)
  • Genetic and genomic analyses might be able. (awionline.org)
  • Graham King has developed and characterised a range of Brassica genetic and genomic resources underpinning crop improvement traits. (edu.au)
  • Using genetic and genomic approaches, we identified several significant genomic markers associated with early abortion. (agri.gov.il)
  • Database of human genetic variants associated with longevity. (senescence.info)
  • The ample use of genome-wide and exome-wide association study methodology (GWAS and EWAS) made it possible to identify a large number of genetic variants associated with diseases. (nih.gov)
  • Why police should not have access to genetic genealogy databases? (ru-facts.com)
  • How do direct-to-consumer genetic testing companies protect their customers' privacy? (medlineplus.gov)
  • If you are considering direct-to-consumer genetic testing , it is important to know how the testing company will protect your information. (medlineplus.gov)
  • Most direct-to-consumer genetic testing companies provide detailed information on their websites about their privacy and security practices. (medlineplus.gov)
  • Reference describing the variation, 'Submitted:' indicating that the mutation was submitted directly to this database. (lumc.nl)
  • With 'precision medicine' on the rise and as improved treatments and novel management strategies become available, sharing data is becoming increasingly important because more observations are needed to understand the relationship between genetic variation and disease. (sinaihealth.ca)
  • Overall, our study highlights that parasites play an important role in shaping host genetic variation and suggests that the use of large sets of neutral markers may be more appropriate for the study of heterozygosity-fitness correlations. (datadryad.org)
  • Thus, genetic variation in noncoding regions of the genome can increase the susceptibility to diseases by disrupting various regulatory elements (promoters, enhancers, silencers, insulator regions, etc. (nih.gov)
  • Genetic variation is low (Matsui and Hayashi 1992, Matsui et al. (amphibiaweb.org)
  • Genetic dissection of Iddm26 in the spontaneously diabetic BBDP rat. (mcw.edu)
  • The Next Generation Identification system, or NGI, the successor to the FBI's criminal fingerprint database, is designed to quickly ID crooks through facial recognition, iris matching, tattoo cross-checks and vocal recordings, among other unique traits. (nextgov.com)
  • The mitochondrial gene cytochrome-c-oxidase subunit I ( COI ) is like a genetic fingerprint for animals. (mbari.org)
  • Pearson, W. Using the FASTA program to search protein and DNA sequence databases. (nature.com)
  • A person's genetic data represent personal, private health information. (medlineplus.gov)
  • Once you take the test, who owns your genetic data? (medlineplus.gov)
  • How does the company safeguard your genetic data and other personal information that you provide? (medlineplus.gov)
  • Will the company share your genetic data or sell it to pharmaceutical or biotechnology companies, academic institutions, or nonprofit organizations? (medlineplus.gov)
  • If you do not want your genetic data shared, sold, or used for research, can you opt out? (medlineplus.gov)
  • Many companies now provide explicit information about whether and how your genetic data may be accessed by law enforcement officials. (medlineplus.gov)
  • If you upload your data to public databases, such as those administered by some third-party interpretation services , that information will be available to law enforcement. (medlineplus.gov)
  • When all was said done, U.K. Biobank had assembled one of the largest single genetic data sets ever. (theatlantic.com)
  • This spring, 11 years after the first volunteer gave up a tube of blood, U.K. Biobank announced it would release its full genetic data set to registered scientists in July. (theatlantic.com)
  • U.K. Biobank had done data releases before, including an earlier subset of the genetic data set with just over 100,000 people. (theatlantic.com)
  • Its data is open to anyone in the world, as long as they are a legitimate researcher and pay a fee commensurate with the amount of data they want to access-a couple thousand dollars for the full genetic data. (theatlantic.com)
  • He added: "The use of genetic data allows us to quickly conduct scientific tests. (asumetech.com)
  • The database is the first of its kind in Canada that allows for sharing of DNA data between geographically distant laboratories using a common platform. (sinaihealth.ca)
  • A data frame with each row being a DNA profile and each column a part of a genetic marker. (rdrr.io)
  • The problems are multiplied when biometrics databases are "multimodal," allowing the collection and storage of several different biometrics in one database and combining them with traditional data points like name, address, social security number, gender, race, and date of birth. (eff.org)
  • 4.6 ) How much database disk space is required to store data from a typical text file? (sql.org)
  • Importantly, the genetic data we have shared to public databases will provide a valuable reference for others using eDNA to help reveal the complexity of ocean ecosystems," said Christianson. (mbari.org)
  • Pulmonary function data from 1988 to 2003 were retrieved from the Phoenix Fire Department's medical monitoring database. (cdc.gov)
  • The aim of this study is to interrogate UK Biobank databank, by extracting genetic data of the Myocyte Enhancer Factor 2A (MEF2A) gene and try understand if small genietc variations of the gene do associate with the features of the cardiovascular disease filed in the databank. (ukbiobank.ac.uk)
  • Dissecting the regulatory roles of polymorphic loci have been impossible without close integration of modern experimental approaches with computer analysis of a growing wealth of genetic and biological data obtained using omics technologies. (nih.gov)
  • 3) resources containing in silico predicted data on the potential impact of genetic variants on the transcription factor binding sites. (nih.gov)
  • The database, funded by the National Science Foundation, provides researchers, conservation managers, educators, and the public with access to a wealth of fundamental biological data. (lpzoo.org)
  • Due to the increasingly important role of Personally identifiable information (PII), courts and legislatures have been attempting to balance the interests of the individual in protecting their genetic information with the usefulness and necessity of that same data for criminal investigation. (llrx.com)
  • MDP also tests all isolates for antimicrobial resistance and contributes data to the National Antimicrobial Resistance Monitoring (NARMS) database. (foodsafetynews.com)
  • The electrophysiology data was collected in a highly standardized way to facilitate comparison across all cells in the database. (yale.edu)
  • Data and models from the Allen Cell Types Database are made available to the community under the Allen Institute's Terms of Use and Citation Policy. (yale.edu)
  • Dr Heidi Mattock and use genetic data to identify the etiology of human canceRs. (who.int)
  • DNA databases, or cohesive collections of DNA profiles, of individuals who have opted in to gather more information about their personal genetic history have been susceptible to risk of privacy disclosure of large corporations who own the DNA database data of these individuals. (unc.edu)
  • Genetic toxicologists as experts should consider data quality and reliability, and give a critical review of all available information for sup- port of classification. (cdc.gov)
  • The Tracking Network uses data from the U.S. Census Bureau external icon , hospital and emergency department databases provided by state and/or local health departments, and death certificates from the National Center for Health Statistics to calculate state and local data about heart disease. (cdc.gov)
  • Our data scientists are helping researchers create reliable ways of collecting and managing data associated with complex studies and genetic sequencing efforts. (medlineplus.gov)
  • Future studies in firefighters have been proposed to evaluate the interaction between exposure to products of combustion and genetic polymorphisms in relation to decline in lung function. (cdc.gov)
  • Several of the resulting variables were characterized in the total cohort and tested for familial clustering, heritability, and statistical power in genetic linkage and association studies. (elsevier.com)
  • The cohort assembled in this study offers substantial power to carry out genetic linkage and association studies that use specific clinical features as covariates or as primary phenotypes. (elsevier.com)
  • This huge amount of genetic information, combined with the thousands of other characteristics tracked by U.K. Biobank, allows scientists to look for the genetic determinants of virtually any disease. (theatlantic.com)
  • The high dimensionality of the patients' database and of the panel of SNP of the biobank might help to answer the question. (ukbiobank.ac.uk)
  • These studies then suggest that genetic mutations in the MEF2A gene, able to reduce the gene functionality, might be associated with an increased risk of cardiovascular disease. (ukbiobank.ac.uk)
  • mutations high frequency of IDH1/2 mutations in oligodendrogliomas, astrocytomas and in alteRations in the RB1 pathway in The TET2 gene encodes the -KG- secondary glioblastomas derived thereof low-gRade diffuse gliomas lacking dependent enzyme that catalyses suggests that these tumours share a common genetic alteRations the conversion of 5-methylcytosine to common progenitor cell population. (who.int)
  • Although family health history has been used in clinical practice for generations, as an aid to diagnose and manage hundreds of genetic disorders, it has its limitations, including lack of access to this information for many people. (cdc.gov)
  • As you know, it is often difficult to provide a diagnosis for a young patient with some clinical signs and symptoms of a genetic disorder. (chromodisorder.org)
  • It seems that the genetic diagnosis of BRCA1/BRCA2 has its clinical practice. (knowcancer.com)
  • It has been applied to the clinical service by utilizing DHPLC for the genetic diagnosis of BRCA1 and BRCA2 of breast cancer patients in the department of Genetic Medicine of our hospital. (knowcancer.com)
  • Second, we would lie to set up the new technique of DHPLC combining with direct DNA sequencing in the genetic diagnosis of ovarian cancer patients for the future clinical service in our hospital. (knowcancer.com)
  • The most recent HbA1c values and lipid levels were retrieved from clinical laboratory databases. (cdc.gov)
  • Ouellette, B.F. & Boguski, M.S. Database divisions and homology search files: a guide for the perplexed. (nature.com)
  • Ancestry Global Search is a genealogical search engine that searches all of the databases included in the Ancestry.com Library. (ru-facts.com)
  • Last week, Maryland and Montana passed laws requiring judicial authorization to search consumer DNA databases in criminal investigations. (eff.org)
  • You can use Entrez query syntax to search a subset of the selected BLAST database. (nih.gov)
  • How much does it cost to hire a genetic genealogist? (ru-facts.com)
  • How much does a genetic genealogist make? (ru-facts.com)
  • How much money does a genetic genealogist make? (ru-facts.com)
  • What degree do you need to be a genetic genealogist? (ru-facts.com)
  • As of 2019, the Orange County database included DNA from 150,000 people who would not otherwise be required to give the state their DNA. (eff.org)
  • Lincoln Park Zoo's direct development of the database ended in 2021, but international partners continue to expand this valuable resource. (lpzoo.org)
  • This article documents the addition of 205 microsatellite marker loci to the Molecular Ecology Resources Database. (edu.au)
  • d) and not at all that there are known genetic differences in the metabolism of humans. (anstageslicht.de)
  • Participants included geneticists, obstetricians, pediatricians, epidemiologists, teratologists, dysmorphologists, and genetic counselors who had a particular interest in CVS studies or who represented professional organizations and government agencies. (cdc.gov)
  • Physicians, genetic counselors, therapists and other healthcare professionals, register now to help us learn more about rare chromosome disorders: the associated symptoms, new research and evolving treatments. (chromodisorder.org)
  • We found a significant relationship between probability of infection and host genetic diversity estimated at the subset of neutral markers that was not explained by strong local effects and did not differ among the studied populations. (datadryad.org)
  • Genealogy databases and the future of criminal investigation. (medlineplus.gov)
  • How do police use genetic genealogy? (ru-facts.com)
  • The technique involves uploading a crime scene DNA profile to one or more genetic genealogy databases with the intention of identifying a criminal offender's genetic relatives and, eventually, locating the offender within the family tree. (ru-facts.com)
  • Is genetic genealogy ethical? (ru-facts.com)
  • How do I get into genetic genealogy? (ru-facts.com)
  • The single best way to learn about genetic genealogy is the hands-on approach: test yourself and numerous family members, and then explore the results using the tools at the vendor(s)' website. (ru-facts.com)
  • 2. Books and articles are a good way to gain a basic understanding of the fundamentals of genetic genealogy. (ru-facts.com)
  • These are welcome and important restrictions on forensic genetic genealogy searching (FGGS)-a law enforcement technique that has become increasingly common and impacts the genetic privacy of millions of Americans.Consumer personal. (eff.org)
  • In August, a new DNA profile for Pelkey was generated, uploaded into a public-access genealogy database and yielded several matches that helped construct a family tree for the then-unidentified victim. (homernews.com)
  • He said ABI is utilizing genetic genealogy in an attempt to identify her remains as well. (homernews.com)
  • Researchers wanted to understand more about what men think about being tested, and look at the issues surrounding genetic testing. (cancerresearchuk.org)
  • The researchers did not find this surprising as the men had known about prostate cancer in their family for a long time, but genetic testing was quite new to them. (cancerresearchuk.org)
  • The researchers concluded that this was a useful study to help understand more about the issues related to genetic testing for men with prostate cancer. (cancerresearchuk.org)
  • The researchers say that genetic testing is complicated as cancer risk is a combination of both genetic and environmental factors. (cancerresearchuk.org)
  • The researchers also say that it is important that genetic profiling test results are given alongside detailed individual genetic counselling. (cancerresearchuk.org)
  • Within two weeks, David Howard and Andrew McIntosh, psychiatry researchers at the University of Edinburgh, had posted not one but two preprints, one on genetic variants linked to depression and the other to neuroticism . (theatlantic.com)
  • With so much important genetic information being used globally to understand the underlying genetic influences of diseases, researchers and clinicians need an accessible repository to share this information. (sinaihealth.ca)
  • To this end, scientists at Lincoln Park Zoo's Alexander Center for Applied Population Biology worked with an international team of demographic researchers to develop the COMPADRE and COMADRE Matrix Database, an open-access online repository for MPMs. (lpzoo.org)
  • The GenBank sequence database helps researchers and public health authorities see if the virus is changing in a way that might require different kinds of treatment or prevention. (medlineplus.gov)
  • Issues in searching molecular sequence databases. (nature.com)
  • The present review focuses on the molecular genetic mechanisms by which pathogenic genetic variants affect gene expression. (nih.gov)
  • A triggering event mediating the effect of a pathogenic genetic variant on the level of gene expression can be, for example, a change in the functional activity of transcription factor binding sites (TFBSs) or DNA methylation change, which, in turn, affects the functional activity of promoters or enhancers. (nih.gov)
  • However, it is important to ensure that supportive breeding does not result in inbreeding and loss of genetic variability. (dtu.dk)
  • However, no attempt has been made to investigate the genetic variability and genetic control of the agronomic morphometric characters of the species. (journalcra.com)
  • Understanding the importance of host genetic diversity for coping with parasites and infectious diseases is a long-standing goal in evolutionary biology. (datadryad.org)
  • Whole genome and whole exome sequencing technologies play a very important role in the studies of the genetic aspects of the pathogenesis of various diseases. (nih.gov)
  • However, identification of the mechanisms of influence of pathogenic genetic variants on the diseases risk is difficult due to a wide variety of regulatory elements. (nih.gov)
  • Huge genetic databases are changing how scientists study disease. (theatlantic.com)
  • How do you go about researching a genetic disease? (scienceblogs.com)
  • Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. (healthpartners.com)
  • Nevertheless, in some cases CAD seems to be inherited as a genetic disease. (ukbiobank.ac.uk)
  • Any isolated pathogens are sent for pulsed field gel electrophoresis (PFGE) testing and the resulting genetic pattern is uploaded to the Centers for Disease Control PulseNet database so that it can be matched against human isolates or outbreak patterns. (foodsafetynews.com)
  • Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. (bvsalud.org)
  • In two populations subject to supportive breeding, there were strong indications of reduced effective population sizes, and significant genetic differentiation was observed between different samples from the same population. (dtu.dk)
  • Here, we study the association between probability of infection by avian malaria (Plasmodium relictum) and individual genetic diversity in three blue tit (Cyanistes caeruleus) populations that strongly differ in prevalence of this parasite. (datadryad.org)
  • This database was used to determine the relationships between the ancient Cumanians, modern Hungarians, and Eurasian populations and to estimate the genetic distances between these populations. (blogspot.com)
  • Objective: The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies. (elsevier.com)
  • Loosely defined, bioinformatics is the management and analysis of biological information contained in databases. (the-scientist.com)
  • Due to this revolutionary discovery, a great unification of all biological organisms has occurred, and information-genetic lines of investigations became one of the most promising avenues for gaining an improved perspective not just in the area of biological research but in science as a whole. (hstalks.com)
  • All participants underwent detailed, phenotypic assessment with either the Schedule for Affective Disorders and Schizophrenia-Lifetime Version or one of four versions of the Diagnostic Interview for Genetic Studies. (elsevier.com)
  • Maverick tech entrepreneur Martin Varsavsky , for instance, wrote on his blog in January that 23andMe will take in saliva samples through the mail, then subject them to a fast and relatively inexpensive genetic analysis. (venturebeat.com)
  • CDC will continue to monitor XDR Shigella infections and track Shigella isolates with unique or worrisome antimicrobial susceptibility patterns and genetic resistance markers. (cdc.gov)
  • Understanding the genetic evolution of A [‎H1N1]‎pdm09 and H3N2 viruses can help better select strains to be included in the annual influenza vaccine. (who.int)
  • The WhosAge database contains people and biotech companies that are contributing to increase our understanding of ageing and life-extension. (senescence.info)
  • Advances in understanding the genetic basis of crop traits requires detailed knowledge of the complex genome structure of Brassica species. (edu.au)
  • This database stores tens of billions of associations of genetic variants with human traits, investigated by the scientific community in hundreds of studies. (polyomica.com)
  • Genetic traits may be involved here. (krebsdaten.de)
  • A new bill is moving through Congress that brings us closer to a national vaccine database telling the government whether you're vaccinated. (anh-usa.org)
  • The bill would spend $400 million to modernize state "immunization information systems" which, we are told, are confidential, population-based databases that maintain a record of vaccine administrations. (anh-usa.org)
  • Although public health agencies are beginning to integrate genetic information in outbreak investigations and surveys, we do not know enough right now to use this information to mitigate adverse vaccine effects or target intervention strategies. (cdc.gov)
  • CDC partners with three state laboratories that now act as regional reference centers doing genetic sequencing using CDC's standard testing practices. (cdc.gov)
  • This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research. (awionline.org)
  • Thus, we suggest that electronic medical recording and human genetic databases are considered together in future directions of pharmacovigilance. (toxicolres.org)
  • Of the 50 mutants with an epidermal phenotype, 9 map to human genetic conditions with skin abnormalities. (nature.com)
  • Analyses using the AnAge database to study the evolution of longevity and ageing in vertebrate lineages. (senescence.info)
  • However to improve this strain for industrial use, genetic modification is a priority. (york.ac.uk)
  • No lab-coated genetic modification , just good old fashioned selective breeding - the stuff we've been doing for tens of thousands of years. (marksdailyapple.com)
  • The counselor should also discuss both the mother's and father's risk(s) for transmitting genetic abnormalities to the fetus. (cdc.gov)
  • Chorionic villus sampling (CVS) and amniocentesis are prenatal diagnostic procedures used to detect certain fetal genetic abnormalities. (cdc.gov)
  • A curated database of compounds that modulate longevity in model organisms. (senescence.info)
  • Within organisms , genetic information generally is carried in chromosomes , where it is represented in the chemical structure of particular DNA molecules . (wikipedia.org)
  • First, we will utilize the new technique of DHPCL with direct DNA sequence to set up the database of BRCA1 and BRCA2 gene mutation of ovarian cancer patients in Taiwan. (knowcancer.com)
  • Select the sequence database to run searches against. (nih.gov)
  • If future prostate screening programmes include genetic information to decide on who can be screened, it is important to understand the strengths and the limitations of genetic testing. (cancerresearchuk.org)
  • Thus, we address the characteristics and limitations on retrospective EMR database studies in hospital settings. (toxicolres.org)
  • A combination of subtle positive and negative local effects and/or a saturation threshold in the association between probability of infection and host genetic diversity in combination with increased resistance to parasites in highly homozygous individuals may explain the observed negative quadratic relationship. (datadryad.org)
  • This series has been designed to describe how genetic diversity can be explored using bioinformatics. (hstalks.com)
  • abstract = "Among several methods of extracting association rules that have been reported, a new evolutionary computation method named Genetic Network Programming (GNP) has also shown its effectiveness for small datasets that have a relatively small number of attributes. (upenn.edu)
  • The association of MEF2A genetic variations with CAD then remains an open question. (ukbiobank.ac.uk)
  • Results: The combined database of phenotypic variables contained 197 variables on 5,721 subjects in 1,177 families. (elsevier.com)
  • Conclusions: This is the largest database of phenotypic variables yet assembled for bipolar disorder, and it is now available to the research community. (elsevier.com)
  • But genetic engineering goes beyond the natural limits of breeding within closely related species. (informaction.org)
  • All the characters studied, however, displayed a relatively wide distribution of factor combinations, indicating that the plant species under study has a broad genetic base. (journalcra.com)
  • If we can detect the possibility of genetic mutation earlier, we may deal with the suspected areas of malignancy as soon as possible. (knowcancer.com)
  • Gathering genetic information is important for law enforcement authorities currently engaged in criminal investigations, or for scientists conducting research. (newstarget.com)
  • A study on the genetic control and potential of the important agronomic characters of curcuma zedoaria rosc. (journalcra.com)
  • It will become a most powerful tool to establish the database of BRCA1 or BRCA2 gene mutation of the ovarian cancer patients in Taiwan, when we can use the technique of DHPLC combining with the direct DNA sequencing. (knowcancer.com)
  • Because everyone shares genetic similarities with their relatives, it may have implications not only for your own privacy but for that of people who are related to you. (medlineplus.gov)
  • Database containing 1,000 simulated DNA profiles typed on ten autosomal markers. (rdrr.io)
  • China's collection of genetic samples without consent violates Tibetan rights under international law and strengthens its already ruthless surveillance regime," he said. (newstarget.com)
  • All flu virus samples (about 6,000 to 8,000 samples) submitted to CDC now undergo full genetic sequencing as a first step. (cdc.gov)
  • This study looked at the mental, emotional and social (psychosocial) issues related to genetic testing for prostate cancer risk. (cancerresearchuk.org)
  • This study was one of the first to look at the interpretation of information from genetic profile results. (cancerresearchuk.org)
  • The study team found that although the men found the results of the genetic profiling interesting, they didn't think the results were more significant than their family history of prostate cancer . (cancerresearchuk.org)
  • In a Cochrane Database study, the combination of BRAF plus MEK inhibitors was found to be the best treatment option, followed by BRAF inhibitors and combination of anti‐CLA4 plus anti‐PD1 monoclonal antibodies, anti‐PD1 monoclonal antibodies, MEK inhibitors, anti‐CTAL4 monoclonal antibodies, biochemotherapy, and conventional chemotherapy. (medscape.com)
  • Our study objectives were to assess the evidence for genetic involvement in the rate of lung function decline in a population of firefighters. (cdc.gov)
  • In recent times many companies have developed therapeutic strategies able to delivery engineered genetic products within the human tissues, and if the present study will confirm that MEF2A is associated with atherosclerosis, a targeted delivery of a modified version of the MEF2A gene within the arterial cells might represent a future therapeutic option able to revert atherosclerosis in subject with occluded arteries, or at least to prevent future cardiovascular events. (ukbiobank.ac.uk)