Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Databases devoted to knowledge about specific genes and gene products.
Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
Extensive collections, reputedly complete, of references and citations to books, articles, publications, etc., generally on a single subject or specialized subject area. Databases can operate through automated files, libraries, or computer disks. The concept should be differentiated from DATABASES, FACTUAL which is used for collections of data and facts apart from bibliographic references to them.
Databases containing information about NUCLEIC ACIDS such as BASE SEQUENCE; SNPS; NUCLEIC ACID CONFORMATION; and other properties. Information about the DNA fragments kept in a GENE LIBRARY or GENOMIC LIBRARY is often maintained in DNA databases.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Organized activities related to the storage, location, search, and retrieval of information.
Software designed to store, manipulate, manage, and control data for specific uses.
Sequential operating programs and data which instruct the functioning of a digital computer.
The portion of an interactive computer program that issues messages to and receives commands from a user.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Databases devoted to knowledge about specific chemicals.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
The systematic study of the complete DNA sequences (GENOME) of organisms.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.
Activities performed to identify concepts and aspects of published information and research reports.
A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Integrated set of files, procedures, and equipment for the storage, manipulation, and retrieval of information.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.
Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.
A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)
Systems where the input data enter the computer directly from the point of origin (usually a terminal or workstation) and/or in which output data are transmitted directly to that terminal point of origin. (Sippl, Computer Dictionary, 4th ed)
A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)
The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.
Specific languages used to prepare computer programs.
The relationships of groups of organisms as reflected by their genetic makeup.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
An optical disk storage system for computers on which data can be read or from which data can be retrieved but not entered or modified. A CD-ROM unit is almost identical to the compact disk playback device for home use.
A publication issued at stated, more or less regular, intervals.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Specifications and instructions applied to the software.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
Methods for determining interaction between PROTEINS.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The influence of study results on the chances of publication and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
Systematic organization, storage, retrieval, and dissemination of specialized information, especially of a scientific or technical nature (From ALA Glossary of Library and Information Science, 1983). It often involves authenticating or validating information.
Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Computer processing of a language with rules that reflect and describe current usage rather than prescribed usage.
The creation and maintenance of medical and vital records in multiple institutions in a manner that will facilitate the combined use of the records of identified individuals.
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
The science concerned with the benefit and risk of drugs used in populations and the analysis of the outcomes of drug therapies. Pharmacoepidemiologic data come from both clinical trials and epidemiological studies with emphasis on methods for the detection and evaluation of drug-related adverse effects, assessment of risk vs benefit ratios in drug therapy, patterns of drug utilization, the cost-effectiveness of specific drugs, methodology of postmarketing surveillance, and the relation between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines. (Pharmacoepidemiol Drug Saf 1992;1(1); J Pharmacoepidemiol 1990;1(1))
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.
Any method used for determining the location of and relative distances between genes on a chromosome.
The protein complement of an organism coded for by its genome.
Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.
The genetic complement of a plant (PLANTS) as represented in its DNA.
Terms or expressions which provide the major means of access by subject to the bibliographic unit.
The systematic study of the complete complement of proteins (PROTEOME) of organisms.
Services providing pharmaceutic and therapeutic drug information and consultation.
Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.
The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various aspects of health care and medicine.
The circulation or wide dispersal of information.
The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.
A research and development program initiated by the NATIONAL LIBRARY OF MEDICINE to build knowledge sources for the purpose of aiding the development of systems that help health professionals retrieve and integrate biomedical information. The knowledge sources can be used to link disparate information systems to overcome retrieval problems caused by differences in terminology and the scattering of relevant information across many databases. The three knowledge sources are the Metathesaurus, the Semantic Network, and the Specialist Lexicon.
The field of information science concerned with the analysis and dissemination of data through the application of computers.
A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.
A multistage process that includes cloning, physical mapping, subcloning, sequencing, and information analysis of an RNA SEQUENCE.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
In INFORMATION RETRIEVAL, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed)
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
Computerized compilations of information units (text, sound, graphics, and/or video) interconnected by logical nonlinear linkages that enable users to follow optimal paths through the material and also the systems used to create and display this information. (From Thesaurus of ERIC Descriptors, 1994)
The application of technology to the solution of medical problems.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A coordinated effort of researchers to map (CHROMOSOME MAPPING) and sequence (SEQUENCE ANALYSIS, DNA) the human GENOME.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
The genetic complement of a BACTERIA as represented in its DNA.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The degree of similarity between sequences. Studies of AMINO ACID SEQUENCE HOMOLOGY and NUCLEIC ACID SEQUENCE HOMOLOGY provide useful information about the genetic relatedness of genes, gene products, and species.
Evaluation of biomedical technology in relation to cost, efficacy, utilization, etc., and its future impact on social, ethical, and legal systems.
The relationships between symbols and their meanings.
Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as RANDOMIZED CONTROLLED TRIALS AS TOPIC.
The commitment in writing, as authentic evidence, of something having legal importance. The concept includes certificates of birth, death, etc., as well as hospital, medical, and other institutional records.
A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.
One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
Data processing largely performed by automatic means.
Books designed by the arrangement and treatment of their subject matter to be consulted for definite terms of information rather than to be read consecutively. Reference books include DICTIONARIES; ENCYCLOPEDIAS; ATLASES; etc. (From the ALA Glossary of Library and Information Science, 1983)
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Integrated, computer-assisted systems designed to store, manipulate, and retrieve information concerned with the administrative and clinical aspects of providing medical services within the hospital.
The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
Computer-based representation of physical systems and phenomena such as chemical processes.
Elements of limited time intervals, contributing to particular results or situations.
Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)
Systems composed of a computer or computers, peripheral equipment, such as disks, printers, and terminals, and telecommunications capabilities.
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Precise procedural mathematical and logical operations utilized in the study of medical information pertaining to health care.
A measurement index derived from a modification of standard life-table procedures and designed to take account of the quality as well as the duration of survival. This index can be used in assessing the outcome of health care procedures or services. (BIOETHICS Thesaurus, 1994)
Genotypic differences observed among individuals in a population.
Description of pattern of recurrent functions or procedures frequently found in organizational processes, such as notification, decision, and action.
Overlapping of cloned or sequenced DNA to construct a continuous region of a gene, chromosome or genome.
Information application based on a variety of coding methods to minimize the amount of data to be stored, retrieved, or transmitted. Data compression can be applied to various forms of data, such as images and signals. It is used to reduce costs and increase efficiency in the maintenance of large volumes of data.
Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The act of testing the software for compliance with a standard.
The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
The confinement of a patient in a hospital.
The application of genetic analyses and MOLECULAR DIAGNOSTIC TECHNIQUES to legal matters and crime analysis.
The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)
Ordered compilations of item descriptions and sufficient information to afford access to them.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
The visual display of data in a man-machine system. An example is when data is called from the computer and transmitted to a CATHODE RAY TUBE DISPLAY or LIQUID CRYSTAL display.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
The privacy of information and its protection against unauthorized disclosure.
Statistical models of the production, distribution, and consumption of goods and services, as well as of financial considerations. For the application of statistics to the testing and quantifying of economic theories MODELS, ECONOMETRIC is available.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
The chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (ANABOLISM) and the breakdown (CATABOLISM) of organic materials utilized by the living organism.
A cabinet department in the Executive Branch of the United States Government concerned with overall planning, promoting, and administering programs pertaining to VETERANS. It was established March 15, 1989 as a Cabinet-level position.
Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Techniques of nucleotide sequence analysis that increase the range, complexity, sensitivity, and accuracy of results by greatly increasing the scale of operations and thus the number of nucleotides, and the number of copies of each nucleotide sequenced. The sequencing may be done by analysis of the synthesis or ligation products, hybridization to preexisting sequences, etc.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A stochastic process such that the conditional probability distribution for a state at any future instant, given the present state, is unaffected by any additional knowledge of the past history of the system.
An infant during the first month after birth.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The functional hereditary units of PLANTS.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Graphs representing sets of measurable, non-covalent physical contacts with specific PROTEINS in living organisms or in cells.
Any deviation of results or inferences from the truth, or processes leading to such deviation. Bias can result from several sources: one-sided or systematic variations in measurement from the true value (systematic error); flaws in study design; deviation of inferences, interpretations, or analyses based on flawed data or data collection; etc. There is no sense of prejudice or subjectivity implied in the assessment of bias under these conditions.
The quality or state of relating to or affecting two or more nations. (After Merriam-Webster Collegiate Dictionary, 10th ed)
Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.
The design, completion, and filing of forms with the insurer.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are CASE-CONTROL STUDIES; COHORT STUDIES; and CROSS-SECTIONAL STUDIES.
Automated systems applied to the patient care process including diagnosis, therapy, and systems of communicating medical data within the health care setting.
The degree of 3-dimensional shape similarity between proteins. It can be an indication of distant AMINO ACID SEQUENCE HOMOLOGY and used for rational DRUG DESIGN.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A province of eastern Canada. Its capital is Quebec. The region belonged to France from 1627 to 1763 when it was lost to the British. The name is from the Algonquian quilibek meaning the place where waters narrow, referring to the gradually narrowing channel of the St. Lawrence or to the narrows of the river at Cape Diamond. (From Webster's New Geographical Dictionary, 1988, p993 & Room, Brewer's Dictionary of Names, 1992, p440)
Discussion of documents issued by local, regional, or national governments or by their agencies or subdivisions.
Directions written for the obtaining and use of DRUGS.
A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
Controlled operation of an apparatus, process, or system by mechanical or electronic devices that take the place of human organs of observation, effort, and decision. (From Webster's Collegiate Dictionary, 1993)
A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)
Individual's rights to obtain and use information collected or generated by others.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.
Media that facilitate transportability of pertinent information concerning patient's illness across varied providers and geographic locations. Some versions include direct linkages to online consumer health information that is relevant to the health conditions and treatments related to a specific patient.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study).
A management function in which standards and guidelines are developed for the development, maintenance, and handling of forms and records.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.

Relatedness of baculovirus and gypsy retrotransposon envelope proteins. (1/7499)

BACKGROUND: Current evidence suggests that lepidopteran baculoviruses may be divided into two phylogenetic groups based on their envelope fusion proteins. One group utilizes gp64, a low pH-dependent envelope fusion protein, whereas the other employs a protein family (e.g. LD130 in the Lymantria dispar nucleopolyhedrovirus) unrelated to gp64, but that is also low pH-dependent. Database searches with members of the LD130 protein family often record significant levels of homology to envelope proteins from a number of insect retrovirus-like transposable elements of the gypsy class. In this report, the significance of the homology between these two types of envelope proteins is analyzed. RESULTS: The significance of the alignment scores was evaluated using Z-scores that were calculated by comparing the observed alignment score to the distribution of scores obtained for alignments after one of the sequences was subjected to 100 random shuffles of its sequence. These analyses resulted in Z-scores of >9 for members of the LD130 family when compared to most gypsy envelope proteins. Furthermore, in addition to significant levels of sequence homology and the presence of predicted signal sequences and transmembrane domains, members of this family contain a possible a furin cleavage motif, a conserved motif downstream of this site, predicted coiled-coil domains, and a pattern of conserved cysteine residues. CONCLUSIONS: These analyses provide a link between envelope proteins from a group of insect retrovirus-like elements and a baculovirus protein family that includes low-pH-dependent envelope fusion proteins. The ability of gypsy retroelements to transpose from insect into baculovirus genomes suggests a pathway for the exchange of this protein between these viral families.  (+info)

Cultural aspects of cancer genetics: setting a research agenda. (2/7499)

BACKGROUND: Anecdotal evidence suggests that people from non-Anglo-Celtic backgrounds are under-represented at familial cancer clinics in the UK, the USA, and Australia. This article discusses cultural beliefs as a potential key barrier to access, reviews previous empirical research on cultural aspects of cancer genetics, draws implications from findings, and sets a research agenda on the inter-relationships between culture, cancer genetics, and kinship. METHODS: The CD-ROM databases MEDLINE, PsychLIT, CINAHL, and Sociological Abstracts were searched from 1980 onwards. RESULTS: Cultural aspects of cancer genetics is the focus of an emerging body of publications. Almost all studies assessed African-American women with a family history of breast cancer and few studies included more diverse samples, such as Americans of Ashkenazi Jewish background or Hawaiian- and Japanese-Americans. Our analysis of published reports suggests several directions for future research. First, an increased focus on various Asian societies appears warranted. Research outside North America could explore the extent to which findings can be replicated in other multicultural settings. In addition, control group designs are likely to benefit from systematically assessing culture based beliefs and cultural identity in the "majority culture" group used for comparative purposes. CONCLUSION: More data on which to base the provision of culturally appropriate familial cancer clinic services to ethnically diverse societies are needed. Empirical data will assist with culturally appropriate categorisation of people from other cultures into risk groups based on their family histories and provide the basis for the development of culturally appropriate patient education strategies and materials.  (+info)

An efficient algorithm for finding short approximate non-tandem repeats. (3/7499)

We study the problem of approximate non-tandem repeat extraction. Given a long subject string S of length N over a finite alphabet Sigma and a threshold D, we would like to find all short substrings of S of length P that repeat with at most D differences, i.e., insertions, deletions, and mismatches. We give a careful theoretical characterization of the set of seeds (i.e., some maximal exact repeats) required by the algorithm, and prove a sublinear bound on their expected numbers. Using this result, we present a sub-quadratic algorithm for finding all short (i.e., of length O(log N)) approximate repeats. The running time of our algorithm is O(DN(3pow(epsilon)-1)log N), where epsilon = D/P and pow(epsilon) is an increasing, concave function that is 0 when epsilon = 0 and about 0.9 for DNA and protein sequences.  (+info)

Fast optimal leaf ordering for hierarchical clustering. (4/7499)

We present the first practical algorithm for the optimal linear leaf ordering of trees that are generated by hierarchical clustering. Hierarchical clustering has been extensively used to analyze gene expression data, and we show how optimal leaf ordering can reveal biological structure that is not observed with an existing heuristic ordering method. For a tree with n leaves, there are 2(n-1) linear orderings consistent with the structure of the tree. Our optimal leaf ordering algorithm runs in time O(n(4)), and we present further improvements that make the running time of our algorithm practical.  (+info)

GEST: a gene expression search tool based on a novel Bayesian similarity metric. (5/7499)

Gene expression array technology has made possible the assay of expression levels of tens of thousands of genes at a time; large databases of such measurements are currently under construction. One important use of such databases is the ability to search for experiments that have similar gene expression levels as a query, potentially identifying previously unsuspected relationships among cellular states. Such searches depend crucially on the metric used to assess the similarity between pairs of experiments. The complex joint distribution of gene expression levels, particularly their correlational structure and non-normality, make simple similarity metrics such as Euclidean distance or correlational similarity scores suboptimal for use in this application. We present a similarity metric for gene expression array experiments that takes into account the complex joint distribution of expression values. We provide a computationally tractable approximation to this measure, and have implemented a database search tool based on it. We discuss implementation issues and efficiency, and we compare our new metric to other standard metrics.  (+info)

New approaches for reconstructing phylogenies from gene order data. (6/7499)

We report on new techniques we have developed for reconstructing phylogenies on whole genomes. Our mathematical techniques include new polynomial-time methods for bounding the inversion length of a candidate tree and new polynomial-time methods for estimating genomic distances which greatly improve the accuracy of neighbor-joining analyses. We demonstrate the power of these techniques through an extensive performance study based on simulating genome evolution under a wide range of model conditions. Combining these new tools with standard approaches (fast reconstruction with neighbor-joining, exploration of all possible refinements of strict consensus trees, etc.) has allowed us to analyze datasets that were previously considered computationally impractical. In particular, we have conducted a complete phylogenetic analysis of a subset of the Campanulaceae family, confirming various conjectures about the relationships among members of the subset and about the principal mechanism of evolution for their chloroplast genome. We give representative results of the extensive experimentation we conducted on both real and simulated datasets in order to validate and characterize our approaches. We find that our techniques provide very accurate reconstructions of the true tree topology even when the data are generated by processes that include a significant fraction of transpositions and when the data are close to saturation.  (+info)

Designing fast converging phylogenetic methods. (7/7499)

Absolute fast converging phylogenetic reconstruction methods are provably guaranteed to recover the true tree with high probability from sequences that grow only polynomially in the number of leaves, once the edge lengths are bounded arbitrarily from above and below. Only a few methods have been determined to be absolute fast converging; these have all been developed in just the last few years, and most are polynomial time. In this paper, we compare pre-existing fast converging methods as well as some new polynomial time methods that we have developed. Our study, based upon simulating evolution under a wide range of model conditions, establishes that our new methods outperform both neighbor joining and the previous fast converging methods, returning very accurate large trees, when these other methods do poorly.  (+info)

Inferring subnetworks from perturbed expression profiles. (8/7499)

Genome-wide expression profiles of genetic mutants provide a wide variety of measurements of cellular responses to perturbations. Typical analysis of such data identifies genes affected by perturbation and uses clustering to group genes of similar function. In this paper we discover a finer structure of interactions between genes, such as causality, mediation, activation, and inhibition by using a Bayesian network framework. We extend this framework to correctly handle perturbations, and to identify significant subnetworks of interacting genes. We apply this method to expression data of S. cerevisiae mutants and uncover a variety of structured metabolic, signaling and regulatory pathways.  (+info)

2007 (English)In: The Ethics and Governance of Human Genetic Databases: European Perspectives / [ed] Matti Häyry, Ruth Chadwick, Vilhjálmur Árnason & Gardar Árnason, Cambridge: Cambridge University Press, 2007, no 4, 108-119 p.Chapter in book (Other academic) ...
770 full-length cDNAs. Analysis of the mouse transcriptome based on functional annotation of 60s profile, publications, research topics, and co-authors
The Gene Expression Database (GXD) is a community resource that stores and integrates expression information for the laboratory mouse, with a particular emphasis on mouse development, and makes these data freely available in formats appropriate for comprehensive analysis. GXD is implemented as a relational database and integrated with the Mouse Genome Database (MGD) to enable global analysis of genotype, expression and phenotype information. Interconnections with sequence databases and with databases from other species further extend GXDs utility for the analysis of gene expression data. GXD is available through the Mouse Genome Informatics Web Site at http://www.informatics.jax.org/
In a continuation of a 2014 conference that explored regulatory considerations and strategies for next-generation sequencing, the Friends of Cancer Research, with support from Alexandria Real Estate Equities, Inc, Pasadena, California, met to discuss the issues and problems of coordinating drug and diagnostic development, specifically the use of curated databases.. Ellen V. Sigal, PhD, Chair and Founder of Friends of Cancer Research, introduced the gathering by noting that high-throughput genomic technologies, including next-generation sequencing, allow for rapid assessment of many analytes and can help predict patients risk of developing certain cancers and how they might respond to therapies. There are many advantages of high-throughput sequencing over that of a single analyte, but demonstrating its adequacy for clinical use is challenging, particularly the tension between the need to ensure validity and the practical limitations of submitting data for every possible variant.. She added ...
TY - JOUR. T1 - Analysis of the mouse transcriptome for genes involved in the function of the nervous system. AU - Gustincich, Stefano. AU - Batalov, Serge. AU - Beisel, Kirk W.. AU - Bono, Hidemasa. AU - Carninci, Piero. AU - Fletcher, Colin F.. AU - Grimmond, Sean. AU - Hirokawa, Nobutaka. AU - Jarvis, Erich D.. AU - Jegla, Tim. AU - Kawasawa, Yuka. AU - LeMieux, Julianna. AU - Miki, Harukata. AU - Raviola, Elio. AU - Teasdale, Rohan D.. AU - Tominaga, Naoko. AU - Yagi, Ken. AU - Zimmer, Andreas. AU - Arakawa, Takahiro. AU - Waki, Kazunori. AU - Kawai, Jun. AU - Hayashizaki, Yoshihide. AU - Okazaki, Yasushi. PY - 2003/6/1. Y1 - 2003/6/1. N2 - We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins. We also identified previously unknown candidates for ...
The rich knowledge of morphological variation among organisms reported in the systematic literature has remained in free-text format, impractical for use in large-scale synthetic phylogenetic work. This noncomputable format has also precluded linkage to the large knowledgebase of genomic, genetic, developmental, and phenotype data in model organism databases. We have undertaken an effort to prototype a curated, ontology-based evolutionary morphology database that maps to these genetic databases (http://kb.phenoscape.org) to facilitate investigation into the mechanistic basis and evolution of phenotypic diversity. Among the first requirements in establishing this database was the development of a multispecies anatomy ontology with the goal of capturing anatomical data in a systematic and computable manner. An ontology is a formal representation of a set of concepts with defined relationships between those concepts. Multispecies anatomy ontologies in particular are an efficient way to represent ...
The browser lines at the beginning of the custom track indicate which native tracks to turn on along their visibilities, while the hide all line turns all the other native tracks off. In addition to these basic instructions there are many more examples on the UCSC Genome Browser Wiki.. What about when you want to view a genome and annotations not hosted on our site? If you have a FASTA file of your genome available, you can use faToTwoBit to convert your genome into a 2bit file, then make an assembly hub out of your data. Once youve created your hub, you can view the hub with the hubUrl setting. As an example, I have hosted an assembly hub for Arabadopsis thaliana here, and I can view the hub via a single URL like so ...
The GMOD project is a confederation of intercompatible open-source projects developing software tools for storing, managing, curating, and publishing biological data. Although the GMOD project originated from the goal of developing a generic tool set for common needs among model organism databases, GMOD tools are meanwhile used by many large and small, collaborative and single-investigator biological database projects for the dissemination of results of experimental research and curated knowledge. GMODs software tools provide a powerful and feature-rich basis for working with biological, in particular genomic and other molecular data. However, due to GMODs historical emphasis on single-genome projects many GMOD tools still lack features that are critical to effectively support the comparative, phylogenetic, and natural diversity-oriented questions frequently asked in evolutionary research. Recent developments have given rise to a window of opportunity for forging collaborations towards filling ...
Researchers from the University of Maryland School of Medicines (UMSOM) Institute for Genome Sciences (IGS) have created VIRGO (human vaginal non-redundant gene catalog): the first genomic catalog of the vaginal microbiome.
GeneWeaver is a web application for the integrated cross-species analysis of functional genomics data to find convergent evidence from heterogeneous sources. The application consists of a large database of gene sets curated from multiple public data resources and curated submissions, along with a suite of analysis tools designed to allow flexible, customized workflows through web-based interactive analysis or scripted API driven analysis. Gene sets come from multiple widely studied species and include ontology annotations, brain gene expression atlases, systems genetic study results, gene regulatory information, pathway databases, drug interaction databases and many other sources. Users can retrieve, store, analyze and share gene sets through a graded access system. Analysis tools are based on combinatorics and statistical methods for comparing, contrasting and classifying gene sets based on their members.. ...
GeneWeaver is a web application for the integrated cross-species analysis of functional genomics data to find convergent evidence from heterogeneous sources. The application consists of a large database of gene sets curated from multiple public data resources and curated submissions, along with a suite of analysis tools designed to allow flexible, customized workflows through web-based interactive analysis or scripted API driven analysis. Gene sets come from multiple widely studied species and include ontology annotations, brain gene expression atlases, systems genetic study results, gene regulatory information, pathway databases, drug interaction databases and many other sources. Users can retrieve, store, analyze and share gene sets through a graded access system. Analysis tools are based on combinatorics and statistical methods for comparing, contrasting, and classifying gene sets based on their members.. ...
To whom it may concern: The completion of the sequencing of the entire DNA of the S. cerevisae genome, is a major event in the history of biology. All those involved are to be congratulated as we now have the first full genetic blueprint of a free living eukaryotic organism. The analysis of these gene products will provide us with a powerful tool for reading the genomes of other eukaryotes, particularly those of higher eukaryotes, which represent the majority of the data currently in the genetic databases. The analysis of the yeast genome is provided a useful framework for the annotation of many of the complete genome projects currently nearing completion, as well as the upcoming human genome. The yeast sequence information used to create this yeast webpage was provided by the GeneQuiz Consortium and the Mips Genome Commission . We have made an initial attempt to integrate these two data structures as well as supplement their annotation with that obtained ,From a set of functionally diagnostic ...
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TY - JOUR. T1 - Mining cancer gene expression databases for latent information on intronic microRNAs. AU - Monterisi, Simona. AU - DArio, Giovanni. AU - Dama, Elisa. AU - Rotmensz, Nicole. AU - Confalonieri, Stefano. AU - Tordonato, Chiara. AU - Troglio, Flavia. AU - Bertalot, Giovanni. AU - Maisonneuve, Patrick. AU - Viale, Giuseppe. AU - Nicassio, Francesco. AU - Vecchi, Manuela. AU - Di Fiore, Pier Paolo. AU - Bianchi, Fabrizio. PY - 2015/2/1. Y1 - 2015/2/1. N2 - Around 50% of all human microRNAs reside within introns of coding genes and are usually co-transcribed. Gene expression datasets, therefore, should contain a wealth of miRNA-relevant latent information, exploitable for many basic and translational research aims. The present study was undertaken to investigate this possibility. We developed an in silico approach to identify intronic-miRNAs relevant to breast cancer, using public gene expression datasets. This led to the identification of a miRNA signature for aggressive breast ...
de Leeuw N, Dijkhuizen T, Hehir-Kwa JY, Carter NP, Feuk L, Firth HV, Kuhn RM, Ledbetter DH, Martin CL, van Ravenswaaij-Arts CM, Scherer SW, Shams S, Van Vooren S, Sijmons R, Swertz M, Hastings R. Diagnostic interpretation of array data using public databases and internet sources. Hum Mutat. 2012 Jun;33(6):930-40. PMID: 26285306; PMC: PMC5027376 Dreszer TR, Karolchik D, Zweig AS, Hinrichs AS, Raney BJ, Kuhn RM, Meyer LR, Wong M, Sloan CA, Rosenbloom KR, Roe G, Rhead B, Pohl A, Malladi VS, Li CH, Learned K, Kirkup V, Hsu F, Harte RA, Guruvadoo L, Goldman M, Giardine BM, Fujita PA, Diekhans M, Cline MS, Clawson H, Barber GP, Haussler D, Kent WJ The UCSC Genome Browser database: extensions and updates 2011. Nucleic Acids Res. 2012 Jan;40(Database issue):D918-23. PMID: 22086951; PMC: PMC3245018. ENCODE Project Consortium, Dunham I, Kundaje A, Aldred SF, Collins PJ, Davis CA, Doyle F, Epstein CB, Frietze S, Harrow J et al. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
MicroRNAs (miRNAs) play a vital role in the development of ovarian cancer (OC). The aim of this study to investigate the prognostic value and potential signaling pathways of hsa-miR-9-5p (miR-9) in OC through literature review and bioinformatics methods. The expression of miR-9 in OC was assessed using the public datasets from the Gene Expression Omnibus (GEO) database. And a literature review was also performed to investigate the correlation between miR-9 expression and the OC prognosis. Two mRNA datasets (GSE18520 and GSE36668) of OC tissues and normal ovarian tissues (NOTs) were downloaded from GEO to identify the differentially expressed genes (DEGs). The target genes of hsa-miR-9-5p (TG-miR-9-5p) were predicted using miRWALK3.0 and TargetScan. Then the gene overlaps between DEGs in OC and the predicted TG-miR-9-5p were confirmed using a Venn diagram. After that, overlapping genes were subjected to Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway
The HGNC Comparison of Orthology Predictions (HCOP) search is a tool that integrates and displays the orthology assertions predicted for a specified human gene, or set of human genes, by eggNOG, Ensembl Compara, HGNC, HomoloGene, Inparanoid, NCBI Gene Orthology, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, PomBase, TreeFam and ZFIN.
The HGNC Comparison of Orthology Predictions (HCOP) search is a tool that integrates and displays the orthology assertions predicted for a specified human gene, or set of human genes, by eggNOG, Ensembl Compara, HGNC, HomoloGene, Inparanoid, NCBI Gene Orthology, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, PomBase, TreeFam and ZFIN.
The remainder of corrections will most likely require the curator to go back to the paper to determine how the entity in the extension is related to the primary GO term annotated (this demonstrates that the meaning of the existing annotation is not clear and should be modified). If a curator comes across an example that is not covered by this guidance, and it is not clear how the annotation should be updated, the example should be brought to an annotation call to be discussed and resolved. Additional recommendations have been made for specific annotations on previous annotation calls; http://wiki.geneontology.org/index.php/Annotation_Conf._Call,_June_23,_2015 http://wiki.geneontology.org/index.php/Annotation_Conf._Call,_July_28,_2015 See the Excel spreadsheet containing details of annotations using deprecated relations, with assigned_by information ...
Once the MODs annotations have been integrated into our database, UniProt-GOA will provide the MOD with a file in the GAF2.0 format containing the entire set of GO annotations that match the taxon identifier(s) the MOD is responsible for as well as any additional annotations the MOD has created to other taxons. When importing the annotations back into their own database, the MOD can either note the updates made in this set from the changes in the date attached to each annotation (dates indicate when the last edit was made to the annotation) or they can carry out a full delete and reload of their GO annotation set. Any annotations that we cannot accept from the MOD, but which the MOD wants to keep can be appended to the supplied GAF by the MOD, e.g. annotations to non-coding RNAs, annotations using internal references that arent mapped to a GO_REF, IEA annotations, etc. UniProt-GOA will not store the annotations that are excluded, so it is up to the MOD to keep a record of these. If required, ...
Accessing and exploring large-scale genomics data sets remains a significant challenge to researchers without specialist bioinformatics training. We present the integrated PlantGenIE.org platform for exploration of Populus, conifer and Arabidopsis genomics data, which includes expression networks and associated visualization tools. Standard features of a model organism database are provided, including genome browsers, gene list annotation, BLAST homology searches and gene information pages. Community annotation updating is supported via integration of WebApollo. ...
The mouse genome database (MGD, http://www.informatics.jax.org/), the international community database for mouse, provides access to extensive integrated data on the genetics, genomics and biology of the laboratory mouse. The mouse is an excellent and unique animal surrogate for studying normal development and disease processes in humans. Thus, MGDs primary goals are to facilitate the use of mouse models for studying human disease and enable the development of translational research hypotheses based on comparative genotype, phenotype and functional analyses. Core MGD data content includes gene characterization and functions, phenotype and disease model descriptions, DNA and protein sequence data, polymorphisms, gene mapping data and genome coordinates, and comparative gene data focused on mammals. Data are integrated from diverse sources, ranging from major resource centers to individual investigator laboratories and the scientific literature, using a combination of automated processes and
Description== Leflunomide is a an isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. Source: [https://www.ncbi.nlm.nih.gov/mesh/2028012 MeSH] [[File:Screen Shot 2019-04-19 at 2.26.27 PM.png,frame,right, structure, image from PubChem]] ==Alternative names== ==Usage Notes== ==References== *[http://www.xenbase.org/literature/article.do?method=display&articleId=52355 Hatch et al 2016] *[https://pubchem.ncbi.nlm.nih.gov/compound/3899 NCBI PubChem CID:3899] > 4 Xenbase articles contain a reference to Leflunomide according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso] *[[Small Molecules for Xenopus Research,Back To Small Molecules Home Page ...
A program written by UCSC student Jim Kent, called GigAssembler, is used to periodically assemble a widely used public draft version of the human genome sequence using updated data from GenBank at the National Center For Biotechnology Information (NCBI). This assembly is steadily improving as the the public sequencing consortium churns out new data. We will look at the coverage statistics on the latest assembly, and then look at web tools to explore it, and what they find. The three most widely used public annotation browsers are the UCSC Genome browser (genome.ucsc.edu), the Ensembl genome browser (www.ensembl.org), and the NCBI map viewer (www.ncbi.nlm.nih.gov/genome/guide), the latter based on NCBIs own sequence assembly. We will focus on the UCSC browser, which shows a rich variety of data mapped to the genome sequence, including predicted genes, expressed sequence tags, full length mRNAs, genetic and radiation hybrid map markers, cytogenetically mapped clones, single nucleotide ...
Web Portal for International Cancer Research: Cancer Epidemiology and Genetic Databases, Research Programmes, Electronic Publications, Scientific Papers, IARC Press Releases, IARC Training Courses, IARC Fellowships for Cancer Research, IARC Meetings, etc
The Los Angeles Times reports that an Arizona crime lab technician found two felons with remarkably similar genetic profiles, so similar that they would ordinarily be accepted in court as a match, but one felon was black and the other white. The FBI estimated the odds of unrelated people sharing those genetic markers to be as remote as 1 in 113 billion. Dozens of similar matches have been found, and these findings raise questions about the accuracy of the FBIs DNA statistics. Scientists and legal experts want to test the accuracy of official statistics using the nearly 6 million profiles in CODIS, the national system that includes most state and local databases. The FBI has tried to block distribution of the Arizona results and is blocking people from performing similar searches using CODIS. A legal fight is brewing over whether the nations genetic databases ought to be opened to wider scrutiny. At stake is the credibility of the odds often cited in DNA cases, which can suggest an all but ...
topgo r topGO package provides tools for testing GO terms while accounting for the topology of the GO graph. org packages topGO. Asif D. Not required Entrez Gene IDs this example takes Ensembl Gene IDs and calcuates GO enrichment. I have a predefined list of the Ensembl gene IDs n 28 and I want to perform Gene Ontology using topGO in R. We used the R package topGO Alexa amp Rahnenf hrer 2009 to investigate the potential gene ontologies GO that were statistically enriched for the sets of genes identified among outliers and the Topgo Co. Alexa A Rahnenfuhrer J 2020 . Compare cash back offers. 886 2 2366 1346 Both PCA and k estimates were carried out in R v. It supports GO annotation from OrgDb object GMT file and user s own data. LEA . script. printTopGOresult . TopGO R package 45 was used for Gene Ontology enrichment analysis as well as DAVID 6. 2 years ago by al ash 20 lt prev 182 results page 1 of 8 next gt TopGo authors recommend 5 10 for more stable results 1 for no prune. 852 respectively . ...
Don Gilbert pointed out that cheap short sequencers are now available. Lots of people have inexpensive sequnces, but there still is no way to do cheap annotation. Current GMOD clients are species or family centered. Want to make it easy to integrate multiple species. ApiDB is at the point of opening new species databases and web sites with relatively little effort. Comparative genomics came up over and over again, both across species and within species. As data grows and is consolidated, issues of who owns the data and whos responsible for the annotation become more problematic. How does GMOD want to deal with integration issues? How close to the sequencer does GMOD want to get? We dont want to pull the data off the sequencer. Should we position GMOD as something that can feed data into places like Ensembl? Ensembl does not have curation expertise of the MODs. Even if NCBI is wonderful at consolidation, they wont have quality curation. GMOD sits right there, supporting curation. So, we doubt ...
RiceGE : Rice Functional Genomics Database. gebd Rice Genome Browser. iSect Tools, iView Tools and Gene Expression Atlas. Collection of Rice T-DNA/Ds, Rice cDNA, Marker, EST, MPSS, SAGE, Arabidopsis, Maize, Wheat, Barley Homology, Rice Tiling Array and Gene Expression Data. Created and developed by Huaming Chen
RiceGE : Rice Functional Genomics Database. gebd Rice Genome Browser. iSect Tools, iView Tools and Gene Expression Atlas. Collection of Rice T-DNA/Ds, Rice cDNA, Marker, EST, MPSS, SAGE, Arabidopsis, Maize, Wheat, Barley Homology, Rice Tiling Array and Gene Expression Data. Created and developed by Huaming Chen
Dear Pegah Tavakolkhah, , I have one more question. I have read in the description of some GOs , that they are involved in apoptosis or angiogenesis (which are the main , reasons of cancer). I wanted to know if apoptosis or angiogenesis are GO , themselves. And if they are, would their descendant GOs show the GOs , which are responsible for these two processes? If you do a search for terms either using GOOSE or using AmiGO (http://amigo.geneontology.org/), you can find the GO terms apoptosis (GO:0006915; http://amigo.geneontology.org/cgi-bin/amigo/term-details.cgi?term=GO:0006915) and angiogenesis (GO:0001525; http://amigo.geneontology.org/cgi-bin/amigo/term-details.cgi?term=GO:0001525). You can find the gene products that have been associated with these processes (and the more specific child processes), either by choosing the gene product associations link in AmiGO, or by using GOOSE to query the GO database. I hope that is helpful; if you have any more questions, please dont hesitate to ...
GO annotations: Mouse from MGI; Human from GO Annotations @ EBI (GOA); Rat from RGD; Chicken from GOA; Fly from FlyBase; Pfalc from PlasmoDB; Worm from WormBase; Dicty from dictyBase; Yeast from SGD; Zfin from ZFIN; Tair from TAIR/TIGR; Rice from Gramene; Pombe from Sanger GeneDB ...
Column 16 refers to a column in the Gene Ontologys (GO) tab-delimited gene association file (gaf) that WormBase submits to the GO consortium on a regular basis. Column 16 has been referred to as the Annotation Extension column in that it provides a placeholder for curation details that cannot be captured by a GO term alone, for example the substrate upon which an enzyme acts. A number of different types of information could conceivably be entered into Column 16. The list below begins to document the potential use of Column 16 by WormBase curators with any additional information or questions that have arisen during the course of curation. In the GAF, there will be an explicit relationship between the entity in Column 16 and the GO term. The annotation extension relations are viewable here: http://www.geneontology.org/scratch/xps/go_annotation_extension_relations.obo Column 16 curation at WormBase is just beginning and will likely be fleshed out more fully over the next few months. In the ...
Representation and depiction of phenotype information at SOC and HLT level. (A) We used the hierarchical information of the MedDRA ontology to map all phenotypi
FatiGO is a web-accessible application that functions in much the same way as DAVIDs GoCharts, including the ability to specify term-specificity level. Unlike DAVID, FatiGO does not allow the setting of a minimum hit threshold for simplified viewing of only the most highly represented functional categories. Likewise, FatiGO limits the graphical output to only one top-level GO category at a time, whereas DAVID allows the combined viewing of biological process, molecular function, and cellular component annotations simultaneously. FatiGOs static barchart output looks very similar to DAVIDs GoChart; an important distinction is that DAVIDs GoCharts are dynamic, allowing users to drill-down and traverse the GO hierarchy for any subset of genes, view the underlying chart data and associated annotations, and link out to external data repositories including LocusLink and QuickGO. As shown in Table 3 the majority of accession types accepted and functional annotations offered by DAVID are not ...
Description: This session displays a region of the LHX6 gene that highlights a selection of the new tracks added in the previous year for the hg38/GRCh38 human assembly. The tracks shown in this display (from top to bottom) include GENCODE Genes V22, transcription levels assayed across 9 ENCODE cell lines, DNase hypersensitive regions based on data from 95 ENCODE cell lines, genome-wide conservation scores calculated using phastCons, a multiple genome alignment created using Lastz and Multiz, and pathogenic CNVs from the ClinGen database. Adapted from Figure 1 in Speir, et al. The UCSC Genome Browser database: 2016 update. Nucleic Acids Res. 2016 Jan 4;44(D1):D717-25: http://nar.oxfordjournals.org/content/44/D1/D717. ...
Description: This session displays a region of the LHX6 gene that highlights a selection of the new tracks added in the previous year for the hg38/GRCh38 human assembly. The tracks shown in this display (from top to bottom) include GENCODE Genes V22, transcription levels assayed across 9 ENCODE cell lines, DNase hypersensitive regions based on data from 95 ENCODE cell lines, genome-wide conservation scores calculated using phastCons, a multiple genome alignment created using Lastz and Multiz, and pathogenic CNVs from the ClinGen database. Adapted from Figure 1 in Speir, et al. The UCSC Genome Browser database: 2016 update. Nucleic Acids Res. 2016 Jan 4;44(D1):D717-25: http://nar.oxfordjournals.org/content/44/D1/D717. ...
Symbol: This is the official symbol assigned to this strain according to the strain nomenclature guidelines. This is a combination of strain and substrain designations for inbred strains (or symbol and ILAR code for other strain types).. Strain: The official strain symbol.. Substrain: The official substrain symbol - this can be a collection of ILAR lab codes defining the history of this particular strain. Can also be found in pulldown section below with links to the strain report pages.. Full Name: If the strain has a text name then it is displayed here; this is not visible if no name is associated to the strain, as in this example. Ontology ID: The identification number of the strain ontology term assigned by RGD, linked to the term in the ontology browser. In the strain ontology, rat strains are organized in a hierarchical fashion based on the type of strain and the way they were developed.. Also known as: Old symbols and synonyms that were used for the strain. If a strain is renamed to comply ...
Developmental Anatomic Gene Expression Atlas (AGEA) The Allen Gene Expression Atlas (AGEA) for the Developing Mouse Brain is used to understand how voxels of the brain are related by gene expression (Correlation), and to find genes expressed at a particul
The comparability of gene expression data generated with different microarray platforms is still a matter of concern. Here we address the performance and the overlap in the detection of differentially expressed genes for five different microarray platforms in a challenging biological context where differences in gene expression are few and subtle. Gene expression profiles in the hippocampus of five wild-type and five transgenic δC-doublecortin-like kinase mice were evaluated with five microarray platforms: Applied Biosystems, Affymetrix, Agilent, Illumina, LGTC home-spotted arrays. Using a fixed false discovery rate of 10% we detected surprising differences between the number of differentially expressed genes per platform. Four genes were selected by ABI, 130 by Affymetrix, 3,051 by Agilent, 54 by Illumina, and 13 by LGTC. Two genes were found significantly differentially expressed by all platforms and the four genes identified by the ABI platform were found by at least three other platforms.
DEVELOPMENTAL ANATOMIC GENE EXPRESSION ATLAS (AGEA) AGEA is an interactive relational atlas based on spatial correlations of gene expression data for \2000 genes in the Allen Developing Mouse Brain Atlas. AGEA for the Developing Mouse Brain is used to und
The Ensembl human gene annotations have been updated using Ensembls automatic annotation pipeline. The updated annotation incorporates new protein and cDNA sequences which have become publicly available since the last GRCh37 genebuild (March 2009).. In release 67 (May 2012), we continue to display a joint gene set based on the merge between the automatic annotation from Ensembl and the manually curated annotation from Havana. This refined gene set corresponds to GENCODE release 12. The Consensus Coding Sequence (CCDS) identifiers have also been mapped to the annotations. More information about the CCDS project. Updated manual annotation from Havana is merged into the Ensembl annotation every release. Transcripts from the two annotation sources are merged if they share the same internal exon-intron boundaries (i.e. have identical splicing pattern) with slight differences in the terminal exons allowed. Importantly, all Havana transcripts are included in the final Ensembl/Havana merged (GENCODE) ...
Here at the Genome Browser were constantly looking for ways to improve the Browser and make it more accessible. A big part of that is making it as easy as possible for people to learn how to use our tools to best serve their research. In the past this has included setup and maintenance of documentation, including our help docs as well as a dedicated wiki site, where browser staffers and external users alike have shared content. We also continue to offer real-time support on our mailing list ([email protected]).. Thanks to funding support from the NHGRI we were recently able to amp up our training efforts in two ways. We now have a program whereby interested groups can economically host a Genome Browser workshop at their institution. For more information, fill out our intake survey: bit.ly/ucscTraining.. The other thing we have been able to do is launch a YouTube channel where you will find video tutorials explaining how to use various parts of the Browser. While static documents and email ...
TY - JOUR. T1 - ParkDB. T2 - A Parkinsons disease gene expression database. AU - Taccioli, Cristian. AU - Maselli, Vincenza. AU - Tegnér, Jesper. AU - Gomez-Cabrero, David. AU - Altobelli, Gioia. AU - Emmett, Warren. AU - Lescai, Francesco. AU - Gustincich, Stefano. AU - Stupka, Elia. N1 - Generated from Scopus record by KAUST IRTS on 2021-02-16. PY - 2011/12/1. Y1 - 2011/12/1. N2 - Parkinsons disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-Analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and ...
We investigate large functional genomics and high-throughput biological datasets. Assistance is provided in experimental design and subsequent analysis of next-generation sequencing, microarray, and mass-spectrometry-based proteomics experiments. The current focus is on the analysis of small RNA-Seq, mRNA-Seq and haploid ES cell screen data. Gene lists derived from publicly available studies or generated from in-house high-throughput experiments (NGS, microarray, proteomics) are analyzed for the overrepresentation of pathways, GO-terms, functional domains, or placed in interaction networks to visualize their relationships. Genome-wide expression patterns are contextualized with known processes and pathways using Gene Set Enrichment Analysis (GSEA). Local instances of integrated model organism databases and genome annotation portals permit visualization and analysis of in-house data with dedicated resources and additional privacy. User-driven data exploration is supported by the Ingenuity Pathway ...
We investigate large functional genomics and high-throughput biological datasets. Assistance is provided in experimental design and subsequent analysis of next-generation sequencing, microarray, and mass-spectrometry-based proteomics experiments. The current focus is on the analysis of small RNA-Seq, mRNA-Seq and haploid ES cell screen data. Gene lists derived from publicly available studies or generated from in-house high-throughput experiments (NGS, microarray, proteomics) are analyzed for the overrepresentation of pathways, GO-terms, functional domains, or placed in interaction networks to visualize their relationships. Genome-wide expression patterns are contextualized with known processes and pathways using Gene Set Enrichment Analysis (GSEA). Local instances of integrated model organism databases and genome annotation portals permit visualization and analysis of in-house data with dedicated resources and additional privacy. User-driven data exploration is supported by the Ingenuity Pathway ...
Allows to align query sequences against those present in a selected target database. BLAST is a suite of programs, provided by NCBI, which can be used to quickly search a sequence database for matches to a query sequence. The software provides an access point for these tools to perform sequence alignment on the web. The set of BLAST command-line applications is organized in a way that groups together similar types of searches in one application.
Strategies for discovering the genetic polymorphism responsible for an identified quantitative trait locus (QTL) generally follow two paths. One path involves generating additional experimental mapping populations to narrow an initial, wide QTL support interval [1]. For example, Yalcin et al. [2], used outbred mice and a QTL-knockout interaction test to identify Rgs2 as the gene underlying an anxiety phenotype. The other path involves making use of bioinformatic tools and archival data to better nominate candidate genes within a QTL support interval [3, 4]. For example, Flint and colleagues review and apply a hypothesis of human and mouse sequence conservation that may aid QTL gene or polymorphism discovery [5-7]. The combination of approaches should facilitate polymorphism identification, and more rapidly.. The BXD, an increasingly popular tool for mouse complex trait genetics, are a panel of recombinant inbred lines derived by inbreeding progeny from a C57BL/6J × DBA/2J F2 intercross [8]. ...
Cyclome: Arabidopsis Cyclome Functional Genomics Database. gebd Arabidopsis Genome Browser. iSect Tools, iView Tools and Gene Expression Atlas. Collection of Arabidopsis T-DNA/Ds, Full-length cDNA, Marker, EST, MPSS, SAGE, miRNA, sRNA, Arabidopsis Tiling Array and Gene Expression Data. Created and developed by Huaming Chen
Circadian rhythms of cell and organismal physiology are controlled by an autoregulatory transcription-translation feedback loop that regulates the expression of rhythmic genes in a tissue-specific manner. Recent studies have suggested that components of the circadian pacemaker, such as the Clock and …
This is the website for the Reed Labs Butterfly Genome Database at Cornell University.. This site provides a portal for searching and browsing high quality butterfly genome assemblies that are annotated with specialized data types including gene expression (e.g. RNA-seq), chromatin structure, and SNP variation. Data will be added on a rolling basis, and we encourage contributions from other research groups.. Blast: Search genome assemblies and gene predictions using Blast. Genome browser links are embedded in Blast result for your convenience.. Genome Browser: We use the UCSC genome browser as the most powerful current interface for manipulating and viewing complex data tracks. On this page you can go directly to any relevant coordinate in any genome we host.. Downloads: Download genome assemblies and accessory data tracks, as well as custom scripts from Reed Lab publications.. Citations: Publications to cite for specific data sets.. Please note that there are many additional lepidopteran ...
Web Portal for International Cancer Research: Cancer Epidemiology and Genetic Databases, Research Programmes, Electronic Publications, Scientific Papers, IARC Press Releases, IARC Training Courses, IARC Fellowships for Cancer Research, IARC Meetings, etc
Web Portal for International Cancer Research: Cancer Epidemiology and Genetic Databases, Research Programmes, Electronic Publications, Scientific Papers, IARC Press Releases, IARC Training Courses, IARC Fellowships for Cancer Research, IARC Meetings, etc
MaizeGDB is the maize research communitys central repository for genetic and genomic information about the crop plant and research model Zea mays ssp. mays. The MaizeGDB team endeavors to meet research needs as they evolve based on researcher feedback and guidance. Recent work has focused on better integrating existing data with sequence information as it becomes available for the B73, Mo17 and Palomero Toluqueño genomes. Major endeavors along these lines include the implementation of a genome browser to graphically represent genome sequences; implementation of POPcorn, a portal ancillary to MaizeGDB that offers access to independent maize projects and will allow BLAST similarity searches of participating projects data sets from a single point; and a joint MaizeGDB/PlantGDB project to involve the maize community in genome annotation. In addition to summarizing recent achievements and future plans, this article also discusses specific examples of community involvement in setting priorities and design
Bidirectional promoters are short (,1 kbp) intergenic regions of DNA between the 5 ends of the genes in a bidirectional gene pair.[14] A bidirectional gene pair refers to two adjacent genes coded on opposite strands, with their 5 ends oriented toward one another.[15] The two genes are often functionally related, and modification of their shared promoter region allows them to be co-regulated and thus co-expressed.[16] Bidirectional promoters are a common feature of mammalian genomes.[17] About 11% of human genes are bidirectionally paired.[14]. Bidirectionally paired genes in the Gene Ontology database shared at least one database-assigned functional category with their partners 47% of the time.[18] Microarray analysis has shown bidirectionally paired genes to be co-expressed to a higher degree than random genes or neighboring unidirectional genes.[14] Although co-expression does not necessarily indicate co-regulation, methylation of bidirectional promoter regions has been shown to ...
TY - JOUR. T1 - Editorial. T2 - Plant and cell physiologys 2016 online database issue. AU - Ohyanagi, Hajime. AU - Obayashi, Takeshi. AU - Yano, Kentaro. PY - 2016/1/1. Y1 - 2016/1/1. UR - http://www.scopus.com/inward/record.url?scp=84964900062&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84964900062&partnerID=8YFLogxK. U2 - 10.1093/pcp/pcv205. DO - 10.1093/pcp/pcv205. M3 - Review article. C2 - 26801748. AN - SCOPUS:84964900062. VL - 57. SP - 1. EP - 3. JO - Plant and Cell Physiology. JF - Plant and Cell Physiology. SN - 0032-0781. IS - 1. ER - ...
Update of /cvsroot/gmod/apollo/src/java/apollo/config In directory sc8-pr-cvs2.sourceforge.net:/tmp/cvs-serv30809 Modified Files: FeatureProperty.java TiersIO.java Added Files: ChadoJdbcNameAdapter.java Log Message: ChadoJdbcNameAdapter is based on ParameciumNameAdapter but more generic. This Name Adapter queries the database itself to generate new unique ids. It uses two parameters in the tiers config file : idPrefix : PTET chromosomeFormat : scaffold_(\d+) # To get the chromosome number The ParameciumNameAdapter should disapear... --- NEW FILE: ChadoJdbcNameAdapter.java --- package apollo.config; import org.apache.log4j.*; import apollo.datamodel.*; import apollo.editor.AddTransaction; import apollo.editor.CompoundTransaction; import apollo.editor.Transaction; import apollo.editor.TransactionManager; import apollo.editor.TransactionSubpart; import apollo.editor.UpdateTransaction; import java.io.BufferedReader; import java.io.InputStreamReader; import java.io.InputStream; import ...
Position Title: Research Associate (Senior Postdoc) / Research Associate (Postdoc) Working Title: Plant Ontology Project Coordinator How to Apply: -------------- To review the position description and apply, go to posting #0004322 at http://oregonstate.edu/jobs. When applying, you will be required to electronically submit your application, a cover letter citing your interest in the position and your experience, and a CV/resume including 3 references. Closing date 7/15/09. Position description: --------------------- The Plant Ontology Consortium (www.plantontology.org) is seeking applicants for a full-time position of scientific curator who will coordinate the Consortium s efforts. The Plant Ontology Consortium is a collaboration among researchers at Oregon State University, Cornell University and New York Botanical Garden. The Consortium also collaborates with the curators of many model organism databases including rice, Arabidopsis, maize, grasses, legumes, Solanaceae, bryophytes and plant ...
Bioinformatics is currently faced with very large-scale data sets that lead to computational jobs, especially sequence similarity searches, that can take absurdly long times to run. For example, the National Center for Biotechnology Information (NCBI) Basic Local Alignment Search Tool (BLAST and BLAST+) suite, which is by far the most widely used tool for rapid similarity searching among nucleic acid or amino acid sequences, is highly central processing unit (CPU) intensive. While the BLAST suite of programs perform searches very rapidly, they have the potential to be accelerated. In recent years, distributed computing environments have become more widely accessible and used due to the increasing availability of high-performance computing (HPC) systems. Therefore, simple solutions for data parallelization are needed to expedite BLAST and other sequence analysis tools. However, existing software for parallel sequence similarity searches often requires extensive computational experience and skill ...
Description: Beta cell genomics database provides searches and tools to explore detailed information about genes, transcripts, gene interactions, genomic regions, and beta cell related functional genomics studies. Institution: University of Pennsylvania Contacts: Beta Cell Biology Consortium Home Page: http://genomics.betacell.org/gbco/ ...
Tracks contained in the RefSeq annotation and RefSeq RNA alignment tracks were created at UCSC using data from the NCBI RefSeq project. Data files were downloaded from RefSeq in GFF file format and converted to the genePred and PSL table formats for display in the Genome Browser. Information about the NCBI annotation pipeline can be found here.. The RefSeq Diffs track is generated by UCSC using NCBIs RefSeq RNA alignments.. The UCSC RefSeq Genes track is constructed using the same methods as previous RefSeq Genes tracks. RefSeq RNAs were aligned against the human genome using BLAT. Those with an alignment of less than 15% were discarded. When a single RNA aligned in multiple places, the alignment having the highest base identity was identified. Only alignments having a base identity level within 0.1% of the best and at least 96% base identity with the genomic sequence were kept.. ...
Barnes, Michael R. (2003). "Human Genetic Variation: Databases and Concepts". In Barnes, Michael R.; Gray, Ian C. ... SNP-based genetic linkage analysis can be used to map disease loci, and determine disease susceptibility genes in individuals. ... The combination of SNP maps and high density SNP arrays allows SNPs to be used as markers for genetic diseases that have ... SNPs can also be used to study genetic abnormalities in cancer. For example, SNP arrays can be used to study loss of ...
"The Cochrane Database of Systematic Reviews (8): CD009118. doi:10.1002/14651858.CD009118.pub3. PMID 27531591.. ... USDA, ARS, National Genetic Resources Program. "GRIN species records of Senna". Germplasm Resources Information Network-(GRIN ... "International Legume Database & Information Service. Cardiff School of Computer Science & Informatics. Retrieved 6 January 2017 ... "Hawaiian Ethnobotany Online Database. Bernice P. Bishop Museum. Retrieved 2009-03-10.. ...
European Forest Genetic Resources Programme (EUFORGEN). *[1] The Gymnosperm Database. *efri.gov.tr: A case study on stone pine ... Fady, B.; Finesch, S. & Vendramin, G. (2004), Italian stone pine − Pinus pinea: Technical guidelines for genetic conservation ... Pinus pinea − distribution map, genetic conservation units and related resources. ... and use (PDF), European Forest Genetic Resources Programme. *^ PR (20 October 2010). "Italy's pine nut pest". Public Radio ...
database of genetic disorders.. *PubMed: {{PMID}}. -an alternative method of linking to PubMed that shows "PubMed" as the link ... Diseases Database: {{DiseasesDB}}. and {{DiseasesDB2}}. *eMedicine: {{eMedicine}}. and {{eMedicine2}}. -clinical overviews of ... Some good sources may be found from TRIP database or here.. *Wikipedia's guidelines explaining the preferred references for ... It offers a free search engine for accessing the MEDLINE database of biomedical research articles offered by the National ...
Geography, Classification, Genetic Resources and Breeding. "Intan", 468p.. External links[edit]. Wikimedia Commons has media ... "International Legume Database & Information Service. Cardiff School of Computer Science & Informatics. Retrieved 11 April 2014. ... USDA, ARS, National Genetic Resources Program. "GRIN species records of Lupinus". Germplasm Resources Information Network-(GRIN ... eds.) Classification of Lupins. In: Lupins: Geography, Classification, Genetic Resources and Breeding. St. Petersburg: Intan. ...
CS1 maint: discouraged parameter (link) USDA; ARS; National Genetic Resources Program. "GRIN species records of Gigasiphon". ... "ILDIS LegumeWeb entry for Gigasiphon". International Legume Database & Information Service. Cardiff School of Computer Science ... Germplasm Resources Information Network-(GRIN) [Online Database]. National Germplasm Resources Laboratory, Beltsville, Maryland ...
Wikimedia Commons has media related to Genetic promoter regions.. *ORegAnno - Open Regulatory Annotation Database ... Bidirectionally paired genes in the Gene Ontology database shared at least one database-assigned functional category with their ... Some cases of many genetic diseases are associated with variations in promoters or transcription factors. ...
"The Cochrane Database of Systematic Reviews. 12: CD000551. doi:10.1002/14651858.CD000551.pub3. PMC 7045744. PMID 23235576.. ... Cheng K, Ashby D, Smyth RL (September 2017). Cochrane Cystic Fibrosis and Genetic Disorders Group (ed.). "Ursodeoxycholic acid ... "The Cochrane Database of Systematic Reviews. 9: CD000222. doi:10.1002/14651858.CD000222.pub4. PMC 6483662. PMID 28891588.. ... "The Cochrane Database of Systematic Reviews (1): CD003626. doi:10.1002/14651858.CD003626.pub2. PMC 7163275. PMID 21249655.. ...
SzGene database at Schizophrenia Research Forum.. *^ a b Munafò MR, Yalcin B, Willis-Owen SA, Flint J (January 2008). " ... Thapar A, Langley K, Owen MJ, O'Donovan MC (December 2007). "Advances in genetic findings on attention deficit hyperactivity ... "IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.. ... "The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus". American Journal of Human Genetics ...
"GRIN) Online Database. USDA, ARS, National Genetic Resources Program. Retrieved 2007-12-27.. ... "The PLANTS Database. USDA, Baton Rouge, LA 70874-4490 USA. Retrieved 2007-12-18.. ...
Beltsville, Maryland: National Germplasm Resources Laboratory; USDA, ARS, National Genetic Resources Program. Archived from the ... Strecker und Schröder Stuttgart 1908-9 "Compounds in deadly nightshade". Phytochemical and Ethnobotanical Databases. ...
"Cocaine content of plants". USDA, ARS, National Genetic Resources Program. Phytochemical and Ethnobotanical Databases. [Online ... "Atropine content of plants". USDA, ARS, National Genetic Resources Program. Phytochemical and Ethnobotanical Databases. [Online ... Database] National Germplasm Resources Laboratory, Beltsville, Maryland. Archived from the original on November 7, 2004. ... Database] National Germplasm Resources Laboratory, Beltsville, Maryland. Archived from the original on November 7, 2004. ...
Check Hayden, Erika (2013). "Privacy loophole found in genetic databases". Nature. doi:10.1038/nature.2013.12237. S2CID ... Genetic non-discrimination laws have been enacted in some US states and at the federal level, by the Genetic Information ... genetic genealogy and public-records databases." This has led to calls for policy-makers to establish consistent guidelines and ... This use of genetic information to select appropriate drugs is known as pharmacogenomics. This technology may allow treatments ...
"USDA, ARS, National Genetic Resources Program. Phytochemical and Ethnobotanical Databases. National Germplasm Resources ...
"CGD Help: Non-standard Genetic Codes". Candida Genome Database. Retrieved 1 May 2015. Santos, Manuel A. S.; Ueda, Takuya; ... Watanabe, Kimitsuna; Tuite, Mick F. (31 October 2003). "The non-standard genetic code of Candida spp.: an evolving genetic code ... This novel genetic code may be a mechanism for more rapid adaptation to the organism's environment, as well as playing an ... 2015). Some species of Candida use a non-standard genetic code in the translation of their nuclear genes into the amino acid ...
"Invasive and Noxious Weeds". (GRIN) Online Database. USDA, ARS, National Genetic Resources Program. Retrieved 2007-12-26. CS1 ... albertinum". The PLANTS Database. USDA, Baton Rouge, LA 70874-4490 USA. Retrieved 2007-12-18. CS1 maint: discouraged parameter ... The PLANTS Database. USDA, Baton Rouge, LA 70874-4490 USA. Retrieved 2007-12-27. CS1 maint: discouraged parameter (link) Sarah ...
"BioGRID - Database of Protein, Chemical, and Genetic Interactions". thebiogrid.org. Subotić, Ana; Swinnen, Erwin; Demuyser, ... Non-standard Genetic Codes". Candida Genome Database. Retrieved 30 October 2011. Andrzej (Anjay) Elzanowski and Jim Ostell (7 ... Candida Genome Database U.S. National Institutes of Health on the Candida albicans genome Mycobank data on Candida albicans ... This is an unusual example of a departure from the standard genetic code, and most such departures are in start codons or, for ...
"Database of Protein, Chemical, and Genetic Interactions , BioGRID". thebiogrid.org. Retrieved 2016-04-25.. ... "HGNC database of human gene names , HUGO Gene Nomenclature Committee". www.genenames.org. Retrieved 2016-04-25.. ... "Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~". bioinfo.mc.vanderbilt.edu. Retrieved ... There are several options for commercial diagnostic testing for mutations in POLD1.[130] Genetic testing typically includes ...
Genetic Databases. AccessEdit. SNOMED CT is maintained and distributed by SNOMED International, an international non-profit ...
"Detailed information for cultivar: Bosana". Seed and Plant Genetic Resources Service - AGPS. 2005. Retrieved 2009-01-13.. ... "Cultivar name: Bosana". OLEA Databases. Retrieved 2009-01-14. "Bosana" (PDF) (in Spanish). International Olive Council. ... Retrieved 2009-01-13.[permanent dead link] "Agronomical characters for cultivar Bosana". OLEA Databases. Retrieved 2009-01-14 ...
List of all genetic codes: translation tables 1 to 16, and 21 to 31. The genetic codes database. This article incorporates text ... The Condylostoma nuclear code (translation table 28) is a genetic code used by the nuclear genome of the heterotrich ciliate ... Elzanowski A, Ostell J, Leipe D, Soussov V. "The Genetic Codes". Taxonomy browser. National Center for Biotechnology ... "Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum ...
EAAP Animal Genetic Database. Retrieved 27 April 2016. CS1 maint: discouraged parameter (link) Kohl, Wilhelm; Toth, Peter (2014 ...
List of all genetic codes: translation tables 1 to 16, and 21 to 33. The genetic codes database. This article incorporates text ... The Blastocrithidia nuclear code (translation table 31) is a genetic code used by the nuclear genome of the trypanosomatid ... Elzanowski A, Ostell J, Leipe D, Soussov V. "The Genetic Codes". Taxonomy browser. National Center for Biotechnology ... "An Unprecedented Non-canonical Nuclear Genetic Code with All Three Termination Codons Reassigned as Sense Codons". Current ...
List of all genetic codes: translation tables 1 to 16, and 21 to 31. The genetic codes database. This article incorporates text ... The peritrich nuclear code (translation table 30) is a genetic code used by the nuclear genome of the peritrich ciliates ... Elzanowski A, Ostell J, Leipe D, Soussov V. "The Genetic Codes". Taxonomy browser. National Center for Biotechnology ... Sánchez-Silva, Rocı́o; Villalobo, Eduardo; Morin, Loı̈c; Torres, Antonio (2003). "A New Noncanonical Nuclear Genetic Code". ...
Cowrie Genetic Database Project. 2005.. ...
List of all genetic codes: translation tables 1 to 16, and 21 to 31. The genetic codes database. This article incorporates text ... The karyorelictid nuclear code (translation table 27) is a genetic code used by the nuclear genome of the Karyorelictea ciliate ... Elzanowski A, Ostell J, Leipe D, Soussov V. "The Genetic Codes". Taxonomy browser. National Center for Biotechnology ... Swart, Estienne Carl; Serra, Valentina; Petroni, Giulio; Nowacki, Mariusz (2016). "Genetic Codes with No Dedicated Stop Codon: ...
"BioGRID , Database of Protein, Chemical, and Genetic Interactions". thebiogrid.org. Retrieved 2017-05-07. Database, GeneCards ... "GeneCards - Human Genes , Gene Database , Gene Search". www.genecards.org. Retrieved 2017-05-07. Database, GeneCards Human Gene ... "HGNC database of human gene names , HUGO Gene Nomenclature Committee". www.genenames.org. Retrieved 2017-05-07. "Home - UniGene ... Database, GeneCards Human Gene. "TBX4 Gene - GeneCards , TBX4 Protein , TBX4 Antibody". www.genecards.org. Retrieved 2017-05-09 ...
EAAP Animal Genetic Database. Retrieved 2009-04-30. "Breed description: Rouge de l'Ouest". Sheep in United Kingdom. EAAP Animal ... Genetic Database. Retrieved 2009-04-30. "Rouge de l'Ouest". Sheep Breeds - R. Sheep101.info. Retrieved 2009-04-30. British ...
CORD is committed to increasing access to genetic screening and genetic counseling for all rare disorders. Currently, Durhane ... "Halton Community Service Database". Archived from the original on 21 July 2011. Retrieved 22 April 2010. Official Website CORD ... "Genetic Alliance advocacy". Archived from the original on 13 June 2010. Retrieved 23 April 2010. "About CORD". Archived from ...
Cowrie Genetic Database Project. 2005 Conchology Animal Base A. Robin - Encyclopedia of Marine Gastropods, p 95/9 Felix Lorenz ... Lizard Island Field Guide Wild Singapore WMSDB - Worldwide Mollusc Species Data Base Gray, J.E. 1824. Monograph on the family ... World Marine Mollusca database. Accessed through: World Register of Marine Species at http://www.marinespecies.org/aphia.php?p= ...
"The Cochrane Database of Systematic Reviews. 1: CD005060. doi:10.1002/14651858.CD005060.pub3. hdl:1871/48558. PMID 22258959.. ... Main article: Genetic causes of type 2 diabetes. Most cases of diabetes involve many genes, with each being a small contributor ... "The Cochrane Database of Systematic Reviews. 12: CD003054. doi:10.1002/14651858.CD003054.pub4. ISSN 1469-493X. PMC 6486271. ... "The Cochrane Database of Systematic Reviews (11): CD004714. doi:10.1002/14651858.CD004714.pub3. PMC 6486035. PMID 26545069.. ...
"GeoWhen Database". Retrieved March 8, 2011.. *^ a b Encinas, Alfonso; Pérez, Felipe; Nielsen, Sven; Finger, Kenneth L.; ... "New genetic data shows humans and great apes diverged earlier than thought". phys.org. ...
While schizophrenia is widely believed to be multifactorially genetic by biopsychiatrists, no characteristic genetic markers ... The DNA sequence of any genes in this region can then be compared to a database of DNA for genes whose function is already ... then there is a strong chance that the disease is genetic[citation needed] and that the patient will also be a genetic carrier ... If a genetic cause is suspected and little else is known about the illness, then it remains to be seen exactly how many genes ...
"USDA National Nutrient Database, Release 28. 2014. Retrieved 15 May 2013.. *^ Ishida M, Hara M, Fukino N, Kakizaki T, Morimitsu ... Swarup, V.; Chatterjee, S.S. (1972). "Origin and genetic improvement of Indian cauliflower". Economic Botany. 26 (4): 381-393. ... Source: USDA Nutrient Database. 100 grams of raw white cauliflower provides 25 calories, is low in fat, carbohydrates, dietary ... Crisp, P. (1982). "The use of an evolutionary scheme for cauliflowers in screening of genetic resources". Euphytica. 31 (3): ...
Database entry includes a brief justification of why this species is of least concern. ... Corbet, S. W.; Robinson, T. J. (November-December 1991). "Genetic divergence in South African Wildebeest: comparative ...
"The Cochrane Database of Systematic Reviews. 3: CD011154. doi:10.1002/14651858.CD011154.pub2. PMC 7077870. PMID 32175593.. ... Acne can be a feature of rare genetic disorders such as Apert's syndrome.[15] Severe acne may be associated with XYY syndrome.[ ... "The Cochrane Database of Systematic Reviews. 11: CD009435. doi:10.1002/14651858.cd009435.pub2. PMC 6383843. PMID 30484286.. ... "The Cochrane Database of Systematic Reviews. 9: CD007917. doi:10.1002/14651858.CD007917.pub2. PMC 6457763. PMID 27670126. ...
Data based on a 10.5-day-old mouse embryo. Included are the multiple factors for differentiation.[2] ... before any genetic or morphological criteria were put in place for bone marrow or connective tissues. Osteoprogenitor cells can ...
The regulated professions database contains a list of regulated professions for doctor of medicine in the EU member states, EEA ... as the causative genes of most monogenic genetic disorders have now been identified, and the development of techniques in ... A database of objectives covering medical knowledge, as suggested by national societies across the United States, can be ... "A searchable database of medical education objectives - creating a comparable gold standard". BMC Med Educ. 18 (1): 31-39. doi ...
Agrobacterium-mediated genetic engineering techniques were developed in the late 1980s that could successfully transfer genetic ... "GM Crop Database: Event 1345-4". International Life Sciences Institute.. *^ Marcia Wood (July 1995). "Bioengineered Tomatoes ... A genetically modified tomato, or transgenic tomato, is a tomato that has had its genes modified, using genetic engineering. ... Tomato as a model system: I. Genetic and physical mapping of jointless". MGG Molecular & General Genetics. 242 (6). doi:10.1007 ...
Wild Lens species are a significant source of genetic variation for improving the relatively narrow genetic base of this crop. ... According to the USDA National Nutrient Database, 100 g of raw lentils (variety unspecified) provide 353 calories; the same ... Serious genetic improvement for yield has been made, however, the full potential of production and productivity could not yet ... Although lentils have been an important crop for centuries, lentil breeding and genetic research has a relatively short history ...
Molecular genetic testing can be used to confirm the genetic diagnosis of Coffin-Lowry syndrome or to assess pregnancy risk in ... The mission of the Foundation is to provide informational links, resources, and databases to families and patients dealing with ... Molecular genetic testing on a blood specimen or cells from a cheek swab is available to identify mutations in the RSK2 gene. ... Coffin-Lowry syndrome is a genetic disorder that is X-linked dominant and which causes severe mental problems sometimes ...
2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk". Thorax. 59 (3): 259 ... The MEROPS online database for peptidases and their inhibitors: I04.001 Proteopedia: Alpha-1-antitrypsin Alpha-1 antitrypsin at ... a new paradigm for hepatocellular carcinoma in genetic liver disease". Hepatology. 42 (3): 514-21. doi:10.1002/hep.20815. PMID ... Lessons from descriptive studies and analyses of genetic and environmental risk determinants". Clinical and Experimental ...
The Cochrane Database of Systematic Reviews,language=en,volume=6,issue=6,pages=CD000247,doi=10.1002/14651858.CD000247.pub3,pmc= ... ref name="CTgov",{{cite news,url=http://www.cnn.com/2009/HEALTH/02/12/cold.genome/,title=Genetic map of cold virus a step ... The Cochrane Database of Systematic Reviews,language=en,volume=6,issue=6,pages=CD000247,doi=10.1002/14651858.CD000247.pub3,pmc= ... The Cochrane Database of Systematic Reviews,language=en,volume=1,issue=1,pages=CD000980,doi=10.1002/14651858.CD000980.pub4,pmc= ...
"The Reptile Database". Retrieved February 23, 2016.. *^ Tod W. Reeder, Ted M. Townsend, Daniel G. Mulcahy, Brice P. Noonan, ... All genetic studies have supported the hypothesis that turtles are diapsids; some have placed turtles within archosauriformes,[ ... Sri Lanka Wild Life Information Database. *Biology of the Reptilia is an online copy of the full text of a 22 volume 13,000 ... The cladogram below used a combination of genetic (molecular) and fossil (morphological) data to obtain its results.[25] ...
In 2012, a team of scientists from Johns Hopkins University published a genetic compression algorithm that does not use a ... various deduplication and difference-coding techniques are applied that help decorrelate data and describe new data based on ... using both conventional compression algorithms and genetic algorithms adapted to the specific datatype. ...
Molecular genetic studies revealed the traditional classification, based on morphological and anatomical characters, often did ... Amaranthaceae in BoDD - Botanical Dermatology Database. *IUCN link: Amaranthaceae threatened species. *Stanley L. Welsh, ...
... results from excessive intake of preformed vitamin A. A genetic variance in tolerance to vitamin A intake ... See the USDA Nutrient Database for the amount of Vitamin A http://ndb.nal.usda.gov/ ...
"European Database of Asylum Law. 21 March 2018. Retrieved 18 September 2020.. ...
"Host Plant Resistance and Conservation of Genetic Diversity". Radcliffe's IPM World Textbook. University of Minnesota. March ... The points at which it reached three and four billion were not officially noted, but the International Database of the United ... "World Population Prospects: The 2010 Revision Population Database". United Nations. April 15, 2011. Retrieved April 21, 2012.. ... "UN population estimates and projections, database query, August 2009". United Nations. March 11, 2009. Retrieved August 1, 2010 ...
"PhyLoTA project web site - Tools to build the tree of life from sequence databases" (en inglés). Univ. of Arizona. Arquivado ... "The genetic code" (PDF). Nobel Lecture (en inglés). nobelprize.org. Arquivado dende o orixinal (pdf) o 09 de xaneiro de 2009 ... "FDA Clears First of Kind Genetic Lab Test". FDA News (en inglés). FDA. Consultado o 13 de setembro de 2008 ... "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs". Nucleic Acids Research 25 (17). Págs. 3389- ...
Main article: Genetic pollution. Native species can be threatened with extinction[113] through the process of genetic pollution ... "Biological invasions: A field synopsis, systematic review, and database of the literature". Ecology and Evolution. 3 (1): 182- ... Genetic Pollution from Farm Forestry using eucalypt species and hybrids; A report for the RIRDC/L&WA/FWPRDC]; Joint Venture ... For example, L. leucozonium, shown by population genetic analysis to be an invasive species in North America,[77] has become an ...
Genetic defectsEdit. People with albinism often have vision loss to the extent that many are legally blind, though few of them ... Virgili G, Acosta R, Bentley SA, Giacomelli G (2018). "Reading aids for adults with low vision". Cochrane Database Syst Rev. 4 ... Recent advances in mapping of the human genome have identified other genetic causes of low vision or blindness. One such ... Since the estimates of the 1990s, new data based on the 2002 global population show a reduction in the number of people who are ...
Like most positive sense RNA genomes, the genetic material alone is infectious; although substantially less virulent than if ... 2006). "ICTVdB-The Universal Virus Database, version 4". Columbia University, New York, USA. Kahn, Cynthia M.; Line, Scott, eds ... Picornaviridae Virus Pathogen Database and Analysis Resource (ViPR): Picornaviridae ICTV. ...
Because of this, significant debate exists over whether a Warlander will only obtain genetic benefit if it is an F1 hybrid. A ... breeding/4572175196 UELN Database, Universal Equine Life Number, retrieved August 14, 2011 "Find organization with UELN code". ... The Warlander Studbook Society acknowledges that the following genetic defects are known to come from the base breeds of the ... would be likely to suffer from genetic atavism. The statistically tiny number of F2 and subsequent generation Warlander horses ...
The genetic contribution to non-syndromic human obesity.. Nat Rev Genet. (Review). 2009-07, 10 (7): 431-42 [2016-01-11]. PMID ... The Cochrane database of systematic reviews (Meta-analysis, Review). Aug 8, 2014, 8: CD003641. PMID 25105982. doi:10.1002/ ... The Cochrane database of systematic reviews (Meta-analysis, Review). 2014-08-08, 8: CD003641. PMID 25105982. doi:10.1002/ ... Yang W, Kelly T, He J. Genetic epidemiology of obesity. Epidemiol Rev (Review). 2007, 29: 49-61. PMID 17566051. doi:10.1093/ ...
"Cochrane Database Syst. Rev. (9). CD007575. doi:10.1002/14651858.cd007575.pub4. PMC 4004939. PMID 26348534.. ... Singh RJ (2011). Genetic Resources, Chromosome Engineering, and Crop Improvement. Medicinal Plants. 6. Boca Raton: CRC Press. p ... "Cochrane Database Syst. Rev. 3 (3). CD002124. doi:10.1002/14651858.CD002124.pub2. PMID 27000311.. ... Source: USDA Nutrient Database. Similar ingredients. Other members of the family Zingiberaceae are used in similar ways. They ...
The Cochrane Database of Systematic Reviews (10): CD004293. doi:10.1002/14651858.CD004293.pub3. PMID 25318831.. ...
... DB 2.0 - Database of histones and variants at NCBI. *Chromatin, Histones & Cathepsin; PMAP The Proteolysis Map-animation ... "Histone Variants Database 2.0". National Center for Biotechnology Information. Retrieved 13 January 2017.. ...
2006). Documenting domestication: new genetic and archaeological paradigms. Berkeley, Calif.: University of California Press. ... ex Spreng. Medicinal Plant Images Database (School of Chinese Medicine, Hong Kong Baptist University) (in Chinese) (in English) ... which have been variously regarded as either one or two genetic entities.[13] ...
The Cochrane Database of Systematic Reviews. 2016-05-03, (5): CD007689. ISSN 1469-493X. PMID 27136291. doi:10.1002/14651858. ... Contemporary genetic technologies and female reproduction. Hum. Reprod. Update. 2011, 17 (6): 829-47. PMC 3191938. PMID ... De Leo V, Musacchio MC, Cappelli V, Massaro MG, Morgante G, Petraglia F. Genetic, hormonal and metabolic aspects of PCOS: an ... McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine. 12 September 2011 [15 November ...
Genetic info database. What are my chances?. (+2, -1) [vote for,. against] ... In the genetic info database, I add the fact that I have DPD deficiency. The program knows the inheritance pattern of DPD ... There exist large databases in which one can trace geneology. Suppose I receive fluorouracil and almost die, and it is proven ... If she is tested and found not to be DPD deficient, she can add this information to the database under her own name. The risk ...
The big news back in the day was sequencing the human genome. It was a long, laborious process, and the resulting document was hardly a page-turner, but it meant that if someone had the right technology they could reconstruct human DNA from scratch. They could build a human. Now they can build a whole lot of things....
Home , Welcome , Research , Health , Institute for Biomedicine , Conferences , Genetic data in public research databases ... Genetic data in public research databases: Which governance mechanisms should apply?​. April 27-28, 2016, EURAC Bolzano Italy ​ ... However, if the data is deposited in public research databases where the original body loses control over data uses, this may ... explore ethical and legal challenges that may arise when researchers are required to deposit genetic and genomic research data ...
An international database charting gene changes means families previously in the dark about their genetic risk can be offered ... Australian researchers hope database will illuminate genetic risk. Rachael Brown reported this story on Monday, December 23, ... RACHAEL BROWN: Professor Macrae says the database could have wider implications for other rare genetic diseases.. FINLAY MACRAE ... JENNY JENKINS: We were a very fortunate family in that we were one of the first to be able to make use of genetic testing and ...
OMIM Turns 50: A Genetic Databases Past, Present, and Future By Christy Brownlee ... OMIM Turns 50: A Genetic Databases Past, Present, and Future .related-content { clear:both; } p.related-pubs-title { text- ... David Valle is director of the McKusick-Nathans Institute of Genetic Medicine. He works to discover the genetic causes of ... molecular pathway and variant databases, gene-testing registries, clinical trial databases and more. ...
It is a race to acquire genetic knowledge and success is dependent on collaborations and expertise from researchers... ... The database is used primarily by researchers, pathologists, geneticists, genetic counselors and medical oncologists. The ... The BRCA database is among ten other free, open-source databases -focused on inherited diseases-that ARUP provides to the ... Behind the Scenes of Breast Cancer, Researchers Collect Genetic Clues in BRCA Database. ...
... which researchers can use to find genetic codes that determine whos at risk of developing genetic health problems and help ... Intermountain Healthcare building new global DNA database for future genetic discoveries. Intermountain Medical Center ... "Well be able to use the information people submit to validate new genetic and disease findings, discover new genetic mutation ... which researchers can use to find genetic codes that determine whos at risk of developing genetic health problems and help ...
In so many words, the aim is to create a massive database for the greater good. Currently, 23andMes database has genetic ... Of course, such a database raises privacy concerns.. Would you offer your genetic information for such a cause? (Update: ... Seeking Parkinsons cure, Google co-founder Sergey Brin, 23andMe build searchable genetic database. Google co-founder Sergey ...
The goal is to make Alzheimers disease-relevant genetic data available to as many investigators as possible to accelerate ... Largest genetic database on Alzheimers disease now re-open for business. University of Pennsylvania School of Medicine ... "Genetic findings for Alzheimers disease are critical for identifying targets for therapeutic development," Wang said. "Making ... The goal is to make Alzheimers disease-relevant genetic data available to as many investigators as possible to accelerate ...
FDA Approves NIH-Funded Genetic Database, Issues Draft Guidance on NASH. Published: Dec 05, 2018 By Mark Terry ... The database is the Clinical Genome Resource (ClinGen) consortiums ClinGen Expert Curated Human Genetic Data, funded by the ... The FDA also formally recognized a public database that contains data about genes, genetic variants and how they relate to ... In the past, many companies preferred to use their own databases and utilize it as proprietary information. There are also ...
... a request mostly accesses a subset of the entire database. It is, therefore, natural to organize commonl ... In a typical distributed/parallel database system, ...
Genetic and molecular mechanisms underlying spinocerebellar ataxias. Jezierska, J., 2013, Groningen: s.n.. 151 p.. Research ... We discovered the genetic defects underlying two new types of SCA, SCA19 and SCA23. Additionally, we generated cellular models ... SCA is caused by genetic defects and the disease can be transmitted with 50% chance to the offspring. Up to date, 31 SCA types ...
... annotating and integrating of information in different kinds of genomic databases. The use of genetic databases has come to the ... Genetic databases provide new dimensions and new niches to examine the ethics of different traditions of research and to ... As genetic research has moved from Mendelian genetics to sequence maps to the study of human genetic variation at the level of ... The publics expectations of genetic databases and biobanks and how they might shape future choices for individuals and ...
GeneSeeker: extraction and integration of human disease-related information from web-based genetic databases.. van Driel MA1, ... All database searches are performed via the web interfaces provided with the original databases, guaranteeing that the most ... GeneSeeker: extraction and integration of human disease-related information from web-based genetic databases ... GeneSeeker: extraction and integration of human disease-related information from web-based genetic databases ...
Genetic codes is a simple ASN.1 database hosted by the National Center for Biotechnology Information and listing all the known ... Genetic code Galperin, Michael Y; Cochrane Guy R (Jan 2011). "The 2011 Nucleic Acids Research Database Issue and the online ... Molecular Biology Database Collection". Nucleic Acids Res. England. 39 (Database issue): D1-6. doi:10.1093/nar/gkq1243. PMC ...
Home News National Jewish Health Accesses InterMunes Idiopathic Pulmonary Fibrosis DNA Database ... National Jewish Health Accesses InterMunes Idiopathic Pulmonary Fibrosis DNA Database. September 17, 2009. 0 ... InterMune will collaborate with National Jewish Health investigators to help further the research of inherited genetic factors ... The database includes DNA from approximately 1,500 IPF patients. ... GEN - Genetic Engineering and Biotechnology News Mary Ann ...
... problems and suggests a framework for integrating molecular biology databases. It suggests a component datab ...
Researchers worldwide will now have access to genetic data linked to medical information on a diverse group of more than 78,000 ... Kaiser Permanente and UCSF Add Substantial Genetic, Health Information to NIH Online Database. Information is Largest-Ever ... Home > UCSF News Center > Kaiser Permanente and UCSF Add Substantial Genetic, Health Information to NIH Online Database ... The genetic information on more than 78,000 individuals translates into over 55 billion bits of genetic data for the cohort. ...
Applied shotgun metagenomics approach for the genetic characterization of dengue viruses Final publishers version, 1 MB, PDF ... Applied shotgun metagenomics approach for the genetic characterization of dengue viruses. Lizarazo, E., Couto, N., Vincenti- ...
The genome Aggregation Database (gnomAD) population of 138,632 unrelated individuals was searched for previously identified ... classified as pathogenic or unknown on the disease genetic variant database ( http://www.arvcdatabase.info/ ), in five most- ... The ARVC/D Genetic Variants Database listed 364 pathogenic and 266 unknown variants across the five major ARVC genes: PKP2, DSP ... The ARVC/D Genetic Variants Database is a freely available collection of variants associated with ARVC and can be accessed via ...
LongevityMap: Genetic association studies of longevity. Welcome to the LongevityMap, a database of human genetic variants ... A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments ... If you find an error or wish to propose a study or variant to be included in the database, please contact us. To receive the ... A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms ...
Database,of,Genetic,,Clinical,Research,medicine,medical news today,latest medical news,medical newsletters,current medical news ... U.S. Unveils Database of Genetic, Clinical Research. ...Goal is to advance understanding of ills such as heart disease ... ... 14 (HealthDay News) -- One of the largest collections of genetic and clinical data available free to researchers worldwide has ... SHARe is accessed through the database of Genotypes and Phenotypes (dbGaP), a Web-based resource for archiving and distributing ...
Indian Genetic Disease Database (IGDD) is the first patient based "genetic disease" database of India. It is being developed ... This database keeps track of mutations in the causal genes for that genetic diseases common in India. The database will be ... 39 (Database issue): D933-8. doi:10.1093/nar/gkq1025. PMC 3013653. PMID 21037256. Indian Genetic Disease Database Website. ... The database had been launched and updated in August 2010. From this database, one can obtain patient-based data with respect ...
Maintaining Genetic Diversity Under the Endangered Species Act. EPA Grant Number: F6E11028. Title: Maintaining Genetic ... Endangered Species Act, ESA, salmonids, genetic markers, neutral variation, adaptive variation, conservation, biodiversity,, ... It will elucidate the genetic underpinnings that determine if a given population can be protected under the Act. This work ... enumerating the state of the art in the use of genetic data under the Act. This will also involve a review of the literature on ...
Genetic polymorphisms and mechanisms of neurotoxicity: overview. NEUROTOXICOLOGY Tiffany-Castiglioni E, Venkratraj V, Qian Y ... Understanding the significance of genetic variability in the human PON1 gene. None Furlong CE, Li W-F, Cole TB, Jampsa R, ... Genetic Susceptibility to Pesticides. Grant Number R831709C002 RFA: Centers for Childrens Environmental Health and Disease ... Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. NEUROTOXICOLOGY Furlong CE, Cole ...
We applied the technique of the genetic algorithms and a local methodology integrating the Gauss-Newton and Conjugate Gradient ... Magnetotelluric inversion of one- and two-dimensional synthetic data based on hybrid genetic algorithms. ... Goldberg DE (1989) Genetic algorithms in search, optimization and machine learning. Addison-Wesley, New York, p 403Google ... Ferreira NR, Porsani MJ, Oliveira SP (2003) A hybrid genetic-linear algorithm for 2D inversion of sets of vertical electrical ...
The goal is to make Alzheimers disease-relevant genetic data available to as many investigators as possible to accelerate ... Largest Genetic Database on Alzheimers Disease Now Re-open for Business July 23, 2018 ... "We feel this is a major advance in making genetic data available to the research community to maximize sharing for gene and ... "Genetic findings for Alzheimers disease are critical for identifying targets for therapeutic development," Wang said. "Making ...
Our Current Index Contains 1,992,321 Raw Protein And Genetic Interactions From Major Model Organism Species. ... Welcome to our Database of Protein, Genetic and Chemical Interactions. BioGRID is a biomedical interaction repository with data ... Terms and Conditions , Privacy Policy , CRISPR Database , Osprey , Yeast Kinome , TyersLab.com , SGD , GitHub , YouTube , ... New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of ...
  • A technique's usefulness for law enforcement does not outweigh people's privacy interests in their genetic data. (eff.org)
  • This news may fuel concerns surrounding the conflict between people's rights to genetic privacy and compliance with law enforcement. (toptenreviews.com)
  • The California team, led by geneticist Olin D. Anderson, curates the massive GrainGenes database. (nwtntoday.com)
  • Plans call for Chao's database to become accessible through GrainGenes. (nwtntoday.com)
  • Breeders looking for wheat or barley plants with prized traits could search for those plants and traits on Chao's database via GrainGenes. (nwtntoday.com)
  • The European Glycine Database has a purpose of uniting information about representation of the world soyabean diversity in European genebanks. (nw.ru)
  • The most comprehensive information system on banana genetic resources conserved in genebanks around the world has just launched a new and improved. (bioversityinternational.org)
  • Genetic analysis company Ancestry denied law enforcement access to its database following a warrant from a Pennsylvania court in 2019, according to its recent transparency report . (toptenreviews.com)
  • A new database compiles nutrition information on over 185 neglected and underutilized food species and varieties, researched by partners of the. (bioversityinternational.org)
  • Up until now, nothing has prevented law enforcement from rifling through the genetic data of millions of unsuspecting and innocent Americans. (eff.org)
  • INCREASE will enhance the management and use of Genetic Resources on food legumes, which are crucial for sustainability, food security and human health, as recognized by the new European Protein plan for the innovation of this sector in Europe. (usda.gov)
  • Since availability of efficient genetic engineering tools is a crucial prerequisite for industrial strain development, genetic tool development is extensively discussed. (dtu.dk)
  • The Oman Animal and Plant Genetic Resources Centre, in partnership with Bioversity International and national stakeholders, is building a. (bioversityinternational.org)
  • Last week, Maryland and Montana passed laws requiring judicial authorization to search consumer DNA databases in criminal investigations. (eff.org)
  • For example, it places strict limits on and requires judicial oversight for the covert collection of DNA samples from both potential suspects and their genetic relatives, something we have challenged several times in the courts. (eff.org)
  • But genetic engineering goes beyond the natural limits of breeding within closely related species. (informaction.org)
  • A range of genetic tools exist for Lactococcus lactis, but for other species of LAB like lactobacilli and pediococci such tools are less well developed. (dtu.dk)
  • The genetic profiles stored in those databases are made up of more than half a million single nucleotide polymorphisms ("SNPs") that span the entirety of the human genome. (eff.org)
  • Known for offering one of the best genealogy sites on the market, Ancestry DNA says it denied police access to its database of 16 million DNA profiles on jurisdictional grounds. (toptenreviews.com)
  • With a massive database of 16 million profiles, it is clear that Ancestry DNA has the capacity to play a pivotal role in investigative genealogy in the future. (toptenreviews.com)
  • Why does the government want to add genetic profiles to the national DNA criminal database? (heenamodi.com)
  • Scientists use an enzyme to cut the desired gene from the source DNA and a bacteria or virus to carry the new genetic material into the cell. (informaction.org)
  • If that wasn't enough genetic splicing and dicing, Harvard scientists attempted a similar feat recently by inserting the genes of a woolly mammoth into elephants in order to recreate the extinct beasts. (entrepreneur.com)
  • Over the course of two years, hundreds of students have researched and collected public records, news articles, and open datasets to build the Atlas of Surveillance database. (eff.org)
  • However, with recent findings from Pew Research Centre revealing that 81% of Americans think the potential risks of personal data collection by companies outweigh the benefits (with 66% saying the same about government data collection) it is clear that Ancestry DNA is keen to show its prioritization of genetic data privacy. (toptenreviews.com)
  • In a potentially terrifying case of life imitating art, the renowned paleontologist who served as the inspiration for Jurassic Park protagonist Dr. Alan Grant is spearheading genetic research that could engineer dinosaurs back into existence within the next five to 10 years, he says. (entrepreneur.com)
  • The Food Safety Research Information Office (FSRIO) operates the Research Projects Database (RPD). (usda.gov)
  • The data users share with consumer DNA databases is extensive and revealing. (eff.org)
  • Companies will even create images of what they think a person looks like based just on their genetic data. (eff.org)
  • However, in using FGGS, officers are rifling through the genetic data of millions of Americans who are not suspects in the investigation and have no connection to the crime whatsoever. (eff.org)
  • These are welcome and important restrictions on forensic genetic genealogy searching (FGGS)-a law enforcement technique that has become increasingly common and impacts the genetic privacy of millions of Americans. (eff.org)
  • Is genetic privacy being compromised? (toptenreviews.com)
  • The best DNA testing kits specialize in connecting people with lost relatives and tracing genealogical heritage, as well as offering insights on genetic health conditions. (toptenreviews.com)
  • The Maryland law regulates other important aspects of genetic investigations as well. (eff.org)
  • However, our policy makers seem to be more concerned with ensuring that any individual requiring any form of mental health care has his or her genetic profile added to the national DNA criminal database. (heenamodi.com)
  • Before officers can pursue FGGS, they must certify to the court that they have already tried searching existing, state-run criminal DNA databases like CODIS, that they have pursued other reasonable investigative leads, and that those searches have failed to identify anyone. (eff.org)
  • Given that members of the Black community are 50% more likely to be referred to the mental health services through the courts, guess who are disproportionately represented on the DNA database as a result? (heenamodi.com)
  • This review discusses opportunities and bottlenecks for cell factory development of Lactic Acid Bacteria (LAB), with an emphasis on lactobacilli and pediococci, their metabolism and genetic tools. (dtu.dk)
  • By harnessing their properties such as thermotolerance and stress resistance, and by using emerging high-throughput genetic tools, these organisms are very promising as versatile cell factories for biorefinery applications. (dtu.dk)
  • As Matilda MacAttram, Director of Black Mental Health UK put it, ' We believe It is imperative that patients, who are innocent of any crime, have their details removed from the DNA database, if we are to live in a society that does not criminalises those who need help. (heenamodi.com)
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)