Databases, Factual
Databases as Topic
Databases, Protein
Databases, Bibliographic
Databases, Nucleic Acid
Internet
Information Storage and Retrieval
Database Management Systems
Software
User-Computer Interface
Computational Biology
Systems Integration
Algorithms
Expressed Sequence Tags
Randomized Controlled Trials as Topic
MEDLINE
Sequence Alignment
Data Mining
Abstracting and Indexing as Topic
Sequence Analysis, Protein
Sequence Analysis, DNA
Terminology as Topic
Molecular Sequence Data
Proteins
Information Systems
PubMed
Computer Graphics
Computer Communication Networks
Online Systems
Vocabulary, Controlled
Molecular Sequence Annotation
Amino Acid Sequence
CD-ROM
Search Engine
Gene Expression Profiling
Evidence-Based Medicine
Treatment Outcome
Review Literature as Topic
Genome
Base Sequence
Knowledge Bases
Publications
Reproducibility of Results
Publication Bias
Cost-Benefit Analysis
Directories as Topic
Documentation
Medical Records Systems, Computerized
National Library of Medicine (U.S.)
Risk Factors
Natural Language Processing
Medical Record Linkage
Gene Library
Research Design
Metabolic Networks and Pathways
Meta-Analysis as Topic
Bibliometrics
Pharmacoepidemiology
Sequence Homology, Amino Acid
Genome, Human
Cluster Analysis
Sequence Analysis
Chromosome Mapping
Artificial Intelligence
Subject Headings
Drug Information Services
Enzymes
Medical Informatics
Classification
Unified Medical Language System
Informatics
MEDLARS
Data Collection
Sensitivity and Specificity
Molecular Biology
Evolution, Molecular
International Classification of Diseases
Sequence Analysis, RNA
Dictionaries as Topic
Pattern Recognition, Automated
Oligonucleotide Array Sequence Analysis
Biomedical Research
Hypermedia
DNA, Complementary
Risk Assessment
Incidence
Human Genome Project
Outcome Assessment (Health Care)
Open Reading Frames
Publishing
Retrospective Studies
Adverse Drug Reaction Reporting Systems
Data Interpretation, Statistical
Multigene Family
Cohort Studies
Sequence Homology
Technology Assessment, Biomedical
Controlled Clinical Trials as Topic
Records as Topic
Disease
Biology
Conserved Sequence
Reference Books
Polymorphism, Single Nucleotide
Odds Ratio
Hospital Information Systems
Toxicology
Quality Control
Computer Simulation
Information Services
Computer Systems
Models, Statistical
Medical Informatics Computing
Quality-Adjusted Life Years
Workflow
Contig Mapping
Data Compression
Clinical Coding
Registries
Transcriptome
Computer Security
Pharmaceutical Preparations
Canada
Forensic Genetics
Health Services Research
Catalogs as Topic
Neoplasms
Drug-Related Side Effects and Adverse Reactions
Data Display
Clinical Trials as Topic
Models, Economic
Prevalence
Metabolomics
Sequence Homology, Nucleic Acid
Metabolism
United States Department of Veterans Affairs
Genetic Diseases, Inborn
Species Specificity
Research
High-Throughput Nucleotide Sequencing
Models, Theoretical
Markov Chains
Cloning, Molecular
Protein Structure, Tertiary
Models, Molecular
Models, Genetic
Protein Interaction Maps
Bias (Epidemiology)
Internationality
Names
Pregnancy
Epidemiologic Studies
Medical Informatics Applications
Structural Homology, Protein
Genetic Predisposition to Disease
Gene Regulatory Networks
Case-Control Studies
Quebec
Government Publications as Topic
Bayes Theorem
Automation
Ontario
Access to Information
Mutation
Forecasting
Electronic Health Records
Mass Spectrometry
Age Factors
Observational Study as Topic
Forms and Records Control
Genes
Archive of mass spectral data files on recordable CD-ROMs and creation and maintenance of a searchable computerized database. (1/10211)
A database containing names of mass spectral data files generated in a forensic toxicology laboratory and two Microsoft Visual Basic programs to maintain and search this database is described. The data files (approximately 0.5 KB/each) were collected from six mass spectrometers during routine casework. Data files were archived on 650 MB (74 min) recordable CD-ROMs. Each recordable CD-ROM was given a unique name, and its list of data file names was placed into the database. The present manuscript describes the use of search and maintenance programs for searching and routine upkeep of the database and creation of CD-ROMs for archiving of data files. (+info)Mining SNPs from EST databases. (2/10211)
There is considerable interest in the discovery and characterization of single nucleotide polymorphisms (SNPs) to enable the analysis of the potential relationships between human genotype and phenotype. Here we present a strategy that permits the rapid discovery of SNPs from publicly available expressed sequence tag (EST) databases. From a set of ESTs derived from 19 different cDNA libraries, we assembled 300,000 distinct sequences and identified 850 mismatches from contiguous EST data sets (candidate SNP sites), without de novo sequencing. Through a polymerase-mediated, single-base, primer extension technique, Genetic Bit Analysis (GBA), we confirmed the presence of a subset of these candidate SNP sites and have estimated the allele frequencies in three human populations with different ethnic origins. Altogether, our approach provides a basis for rapid and efficient regional and genome-wide SNP discovery using data assembled from sequences from different libraries of cDNAs. (+info)An effective approach for analyzing "prefinished" genomic sequence data. (3/10211)
Ongoing efforts to sequence the human genome are already generating large amounts of data, with substantial increases anticipated over the next few years. In most cases, a shotgun sequencing strategy is being used, which rapidly yields most of the primary sequence in incompletely assembled sequence contigs ("prefinished" sequence) and more slowly produces the final, completely assembled sequence ("finished" sequence). Thus, in general, prefinished sequence is produced in excess of finished sequence, and this trend is certain to continue and even accelerate over the next few years. Even at a prefinished stage, genomic sequence represents a rich source of important biological information that is of great interest to many investigators. However, analyzing such data is a challenging and daunting task, both because of its sheer volume and because it can change on a day-by-day basis. To facilitate the discovery and characterization of genes and other important elements within prefinished sequence, we have developed an analytical strategy and system that uses readily available software tools in new combinations. Implementation of this strategy for the analysis of prefinished sequence data from human chromosome 7 has demonstrated that this is a convenient, inexpensive, and extensible solution to the problem of analyzing the large amounts of preliminary data being produced by large-scale sequencing efforts. Our approach is accessible to any investigator who wishes to assimilate additional information about particular sequence data en route to developing richer annotations of a finished sequence. (+info)The Genexpress IMAGE knowledge base of the human brain transcriptome: a prototype integrated resource for functional and computational genomics. (4/10211)
Expression profiles of 5058 human gene transcripts represented by an array of 7451 clones from the first IMAGE Consortium cDNA library from infant brain have been collected by semiquantitative hybridization of the array with complex probes derived by reverse transcription of mRNA from brain and five other human tissues. Twenty-one percent of the clones corresponded to transcripts that could be classified in general categories of low, moderate, or high abundance. These expression profiles were integrated with cDNA clone and sequence clustering and gene mapping information from an upgraded version of the Genexpress Index. For seven gene transcripts found to be transcribed preferentially or specifically in brain, the expression profiles were confirmed by Northern blot analyses of mRNA from eight adult and four fetal tissues, and 15 distinct regions of brain. In four instances, further documentation of the sites of expression was obtained by in situ hybridization of rat-brain tissue sections. A systematic effort was undertaken to further integrate available cytogenetic, genetic, physical, and genic map informations through radiation-hybrid mapping to provide a unique validated map location for each of these genes in relation to the disease map. The resulting Genexpress IMAGE Knowledge Base is illustrated by five examples presented in the printed article with additional data available on a dedicated Web site at the address http://idefix.upr420.vjf.cnrs.fr/EXPR++ +/ welcome.html. (+info)Renal failure predisposes patients to adverse outcome after coronary artery bypass surgery. VA Cooperative Study #5. (5/10211)
BACKGROUND: More than 600,000 coronary artery bypass graft (CABG) procedures are done annually in the United States. Some data indicate that 10 to 20% of patients who are undergoing a CABG procedure have a serum creatinine of more than 1.5 mg/dl. There are few data on the impact of a mild increase in serum creatinine concentration on CABG outcome. METHODS: We analyzed a Veterans Affairs database obtained prospectively from 1992 through 1996 at 14 of 43 centers performing heart surgery. We compared the outcome after CABG in patients with a baseline serum creatinine of less than 1.5 mg/dl (median 1.1 mg/dl, N = 3271) to patients with a baseline serum creatinine of 1.5 to 3.0 mg/dl (median 1.7, N = 631). RESULTS: Univariate analysis revealed that patients with a serum creatinine of 1.5 to 3.0 mg/dl had a higher 30-day mortality (7% vs. 3%, P < 0.001) requirement for prolonged mechanical ventilation (15% vs. 8%, P = 0.001), stroke (7% vs. 2%, P < 0.001), renal failure requiring dialysis at discharge (3% vs. 1%, P < 0.001), and bleeding complications (8% vs. 3%, P < 0.001) than patients with a baseline serum creatinine of less than 1.5 mg/dl. Multiple logistic regression analyses found that patients with a baseline serum creatinine of less than 1.5 mg/dl had significantly lower (P < 0.02) 30-day mortality and postoperative bleeding and ventilatory complications than patients with a serum creatinine of 1.5 to 3.0 mg/dl when controlling for all other variables. CONCLUSION: These results demonstrate that mild renal failure is an independent risk factor for adverse outcome after CABG. (+info)Complete exon-intron organization of the mouse fibulin-1 gene and its comparison with the human fibulin-1 gene. (6/10211)
Fibulin-1 is a 90 kDa calcium-binding protein present in the extracellular matrix and in the blood. Two major variants, C and D, differ in their C-termini as well as the ability to bind the basement membrane protein nidogen. Here we characterized genomic clones encoding the mouse fibulin-1 gene, which contains 18 exons spanning at least 75 kb of DNA. The two variants are generated by alternative splicing of exons in the 3' end. By searching the database we identified most of the exons encoding the human fibulin-1 gene and showed that its exon-intron organization is similar to that of the mouse gene. (+info)Estimation of the number of alpha-helical and beta-strand segments in proteins using circular dichroism spectroscopy. (7/10211)
A simple approach to estimate the number of alpha-helical and beta-strand segments from protein circular dichroism spectra is described. The alpha-helix and beta-sheet conformations in globular protein structures, assigned by DSSP and STRIDE algorithms, were divided into regular and distorted fractions by considering a certain number of terminal residues in a given alpha-helix or beta-strand segment to be distorted. The resulting secondary structure fractions for 29 reference proteins were used in the analyses of circular dichroism spectra by the SELCON method. From the performance indices of the analyses, we determined that, on an average, four residues per alpha-helix and two residues per beta-strand may be considered distorted in proteins. The number of alpha-helical and beta-strand segments and their average length in a given protein were estimated from the fraction of distorted alpha-helix and beta-strand conformations determined from the analysis of circular dichroism spectra. The statistical test for the reference protein set shows the high reliability of such a classification of protein secondary structure. The method was used to analyze the circular dichroism spectra of four additional proteins and the predicted structural characteristics agree with the crystal structure data. (+info)A novel clan of zinc metallopeptidases with possible intramembrane cleavage properties. (8/10211)
Computer-based database searching and protein multiple sequence alignment has identified a novel clan of zinc metallopeptidases, which, by phylogenetic analysis, has been shown to contain six subfamilies. The family is characterized by four common transmembrane segments and three conserved sequence motifs. The combination of topology analysis and motif identification has detected three potential Zn2+ coordinating residues. Only two of the sequences of this novel zinc metallopeptidase clan possess any functional annotation, one of which is able to cleave its substrate within a cytosol/transmembrane segment junction. A number of observations suggest that the remaining members of this novel clan may also cleave their substrates within transmembrane segments. (+info)There are many different types of diseases, ranging from acute and short-term conditions such as the common cold or flu, to chronic and long-term conditions such as diabetes, heart disease, or cancer. Some diseases are infectious, meaning they can be transmitted from one person to another through contact with a contaminated surface or exchange of bodily fluids. Other diseases are non-infectious, meaning they are not transmitted from person to person and are typically caused by genetic mutations or environmental factors.
The diagnosis and treatment of disease is the focus of the medical field, and doctors and other healthcare professionals use a variety of tools and techniques to identify and manage diseases. These may include physical exams, laboratory tests, imaging studies, and medications. In some cases, surgery or other procedures may be necessary to treat a disease.
Some common examples of diseases include:
1. Heart disease: A condition that affects the heart and blood vessels, often caused by high blood pressure, high cholesterol, or smoking.
2. Diabetes: A condition in which the body is unable to properly regulate blood sugar levels, often caused by genetics or obesity.
3. Cancer: A condition in which abnormal cells grow and multiply, often causing damage to surrounding tissues.
4. Inflammatory diseases: Conditions such as arthritis, where the body's immune system causes inflammation and pain in the joints.
5. Neurological diseases: Conditions that affect the brain and nervous system, such as Alzheimer's disease, Parkinson's disease, or multiple sclerosis.
6. Infectious diseases: Conditions caused by the presence of pathogens such as bacteria, viruses, or fungi, including the common cold, flu, and tuberculosis.
7. Genetic diseases: Conditions that are caused by changes in DNA, such as sickle cell anemia or cystic fibrosis.
8. Autoimmune diseases: Conditions where the body's immune system attacks healthy cells and tissues, such as rheumatoid arthritis or lupus.
9. Pulmonary diseases: Conditions that affect the lungs, such as asthma, chronic obstructive pulmonary disease (COPD), or lung cancer.
10. Gastrointestinal diseases: Conditions that affect the digestive system, such as inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS).
These are just a few examples of the many different types of diseases that exist. Diseases can be caused by a wide range of factors, including genetics, lifestyle choices, and environmental factors. Understanding the causes and symptoms of different diseases is important for developing effective treatments and improving patient outcomes.
Neoplasm refers to an abnormal growth of cells that can be benign (non-cancerous) or malignant (cancerous). Neoplasms can occur in any part of the body and can affect various organs and tissues. The term "neoplasm" is often used interchangeably with "tumor," but while all tumors are neoplasms, not all neoplasms are tumors.
Types of Neoplasms
There are many different types of neoplasms, including:
1. Carcinomas: These are malignant tumors that arise in the epithelial cells lining organs and glands. Examples include breast cancer, lung cancer, and colon cancer.
2. Sarcomas: These are malignant tumors that arise in connective tissue, such as bone, cartilage, and fat. Examples include osteosarcoma (bone cancer) and soft tissue sarcoma.
3. Lymphomas: These are cancers of the immune system, specifically affecting the lymph nodes and other lymphoid tissues. Examples include Hodgkin lymphoma and non-Hodgkin lymphoma.
4. Leukemias: These are cancers of the blood and bone marrow that affect the white blood cells. Examples include acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL).
5. Melanomas: These are malignant tumors that arise in the pigment-producing cells called melanocytes. Examples include skin melanoma and eye melanoma.
Causes and Risk Factors of Neoplasms
The exact causes of neoplasms are not fully understood, but there are several known risk factors that can increase the likelihood of developing a neoplasm. These include:
1. Genetic predisposition: Some people may be born with genetic mutations that increase their risk of developing certain types of neoplasms.
2. Environmental factors: Exposure to certain environmental toxins, such as radiation and certain chemicals, can increase the risk of developing a neoplasm.
3. Infection: Some neoplasms are caused by viruses or bacteria. For example, human papillomavirus (HPV) is a common cause of cervical cancer.
4. Lifestyle factors: Factors such as smoking, excessive alcohol consumption, and a poor diet can increase the risk of developing certain types of neoplasms.
5. Family history: A person's risk of developing a neoplasm may be higher if they have a family history of the condition.
Signs and Symptoms of Neoplasms
The signs and symptoms of neoplasms can vary depending on the type of cancer and where it is located in the body. Some common signs and symptoms include:
1. Unusual lumps or swelling
2. Pain
3. Fatigue
4. Weight loss
5. Change in bowel or bladder habits
6. Unexplained bleeding
7. Coughing up blood
8. Hoarseness or a persistent cough
9. Changes in appetite or digestion
10. Skin changes, such as a new mole or a change in the size or color of an existing mole.
Diagnosis and Treatment of Neoplasms
The diagnosis of a neoplasm usually involves a combination of physical examination, imaging tests (such as X-rays, CT scans, or MRI scans), and biopsy. A biopsy involves removing a small sample of tissue from the suspected tumor and examining it under a microscope for cancer cells.
The treatment of neoplasms depends on the type, size, location, and stage of the cancer, as well as the patient's overall health. Some common treatments include:
1. Surgery: Removing the tumor and surrounding tissue can be an effective way to treat many types of cancer.
2. Chemotherapy: Using drugs to kill cancer cells can be effective for some types of cancer, especially if the cancer has spread to other parts of the body.
3. Radiation therapy: Using high-energy radiation to kill cancer cells can be effective for some types of cancer, especially if the cancer is located in a specific area of the body.
4. Immunotherapy: Boosting the body's immune system to fight cancer can be an effective treatment for some types of cancer.
5. Targeted therapy: Using drugs or other substances to target specific molecules on cancer cells can be an effective treatment for some types of cancer.
Prevention of Neoplasms
While it is not always possible to prevent neoplasms, there are several steps that can reduce the risk of developing cancer. These include:
1. Avoiding exposure to known carcinogens (such as tobacco smoke and radiation)
2. Maintaining a healthy diet and lifestyle
3. Getting regular exercise
4. Not smoking or using tobacco products
5. Limiting alcohol consumption
6. Getting vaccinated against certain viruses that are associated with cancer (such as human papillomavirus, or HPV)
7. Participating in screening programs for early detection of cancer (such as mammograms for breast cancer and colonoscopies for colon cancer)
8. Avoiding excessive exposure to sunlight and using protective measures such as sunscreen and hats to prevent skin cancer.
It's important to note that not all cancers can be prevented, and some may be caused by factors that are not yet understood or cannot be controlled. However, by taking these steps, individuals can reduce their risk of developing cancer and improve their overall health and well-being.
There are several types of drug-related side effects and adverse reactions, including:
1. Common side effects: These are side effects that are commonly experienced by patients taking a particular medication. Examples include nausea, dizziness, and fatigue.
2. Serious side effects: These are side effects that can be severe or life-threatening. Examples include allergic reactions, liver damage, and bone marrow suppression.
3. Adverse events: These are any unwanted or harmful effects that occur during the use of a medication, including side effects and other clinical events such as infections or injuries.
4. Drug interactions: These are interactions between two or more drugs that can cause harmful side effects or reduce the effectiveness of one or both drugs.
5. Side effects caused by drug abuse: These are side effects that occur when a medication is taken in larger-than-recommended doses or in a manner other than as directed. Examples include hallucinations, seizures, and overdose.
It's important to note that not all side effects and adverse reactions are caused by the drug itself. Some may be due to other factors, such as underlying medical conditions, other medications being taken, or environmental factors.
To identify and manage drug-related side effects and adverse reactions, healthcare providers will typically ask patients about any symptoms they are experiencing, perform physical exams, and review the patient's medical history and medication list. In some cases, additional tests may be ordered to help diagnose and manage the problem.
Overall, it's important for patients taking medications to be aware of the potential for side effects and adverse reactions, and to report any symptoms or concerns to their healthcare provider promptly. This can help ensure that any issues are identified and addressed early, minimizing the risk of harm and ensuring that the patient receives the best possible care.
These disorders are caused by changes in specific genes that fail to function properly, leading to a cascade of effects that can damage cells and tissues throughout the body. Some inherited diseases are the result of single gene mutations, while others are caused by multiple genetic changes.
Inherited diseases can be diagnosed through various methods, including:
1. Genetic testing: This involves analyzing a person's DNA to identify specific genetic changes that may be causing the disease.
2. Blood tests: These can help identify certain inherited diseases by measuring enzyme levels or identifying specific proteins in the blood.
3. Imaging studies: X-rays, CT scans, and MRI scans can help identify structural changes in the body that may be indicative of an inherited disease.
4. Physical examination: A healthcare provider may perform a physical examination to look for signs of an inherited disease, such as unusual physical features or abnormalities.
Inherited diseases can be treated in various ways, depending on the specific condition and its causes. Some treatments include:
1. Medications: These can help manage symptoms and slow the progression of the disease.
2. Surgery: In some cases, surgery may be necessary to correct physical abnormalities or repair damaged tissues.
3. Gene therapy: This involves using genes to treat or prevent inherited diseases.
4. Rehabilitation: Physical therapy, occupational therapy, and other forms of rehabilitation can help individuals with inherited diseases manage their symptoms and improve their quality of life.
Inherited diseases are a significant public health concern, as they affect millions of people worldwide. However, advances in genetic research and medical technology have led to the development of new treatments and management strategies for these conditions. By working with healthcare providers and advocacy groups, individuals with inherited diseases can access the resources and support they need to manage their conditions and improve their quality of life.
Explanation: Genetic predisposition to disease is influenced by multiple factors, including the presence of inherited genetic mutations or variations, environmental factors, and lifestyle choices. The likelihood of developing a particular disease can be increased by inherited genetic mutations that affect the functioning of specific genes or biological pathways. For example, inherited mutations in the BRCA1 and BRCA2 genes increase the risk of developing breast and ovarian cancer.
The expression of genetic predisposition to disease can vary widely, and not all individuals with a genetic predisposition will develop the disease. Additionally, many factors can influence the likelihood of developing a particular disease, such as environmental exposures, lifestyle choices, and other health conditions.
Inheritance patterns: Genetic predisposition to disease can be inherited in an autosomal dominant, autosomal recessive, or multifactorial pattern, depending on the specific disease and the genetic mutations involved. Autosomal dominant inheritance means that a single copy of the mutated gene is enough to cause the disease, while autosomal recessive inheritance requires two copies of the mutated gene. Multifactorial inheritance involves multiple genes and environmental factors contributing to the development of the disease.
Examples of diseases with a known genetic predisposition:
1. Huntington's disease: An autosomal dominant disorder caused by an expansion of a CAG repeat in the Huntingtin gene, leading to progressive neurodegeneration and cognitive decline.
2. Cystic fibrosis: An autosomal recessive disorder caused by mutations in the CFTR gene, leading to respiratory and digestive problems.
3. BRCA1/2-related breast and ovarian cancer: An inherited increased risk of developing breast and ovarian cancer due to mutations in the BRCA1 or BRCA2 genes.
4. Sickle cell anemia: An autosomal recessive disorder caused by a point mutation in the HBB gene, leading to defective hemoglobin production and red blood cell sickling.
5. Type 1 diabetes: An autoimmune disease caused by a combination of genetic and environmental factors, including multiple genes in the HLA complex.
Understanding the genetic basis of disease can help with early detection, prevention, and treatment. For example, genetic testing can identify individuals who are at risk for certain diseases, allowing for earlier intervention and preventive measures. Additionally, understanding the genetic basis of a disease can inform the development of targeted therapies and personalized medicine."
The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the World Health Organization (WHO). In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.
In this article, we will explore the definition and impact of chronic diseases, as well as strategies for managing and living with them. We will also discuss the importance of early detection and prevention, as well as the role of healthcare providers in addressing the needs of individuals with chronic diseases.
What is a Chronic Disease?
A chronic disease is a condition that lasts for an extended period of time, often affecting daily life and activities. Unlike acute diseases, which have a specific beginning and end, chronic diseases are long-term and persistent. Examples of chronic diseases include:
1. Diabetes
2. Heart disease
3. Arthritis
4. Asthma
5. Cancer
6. Chronic obstructive pulmonary disease (COPD)
7. Chronic kidney disease (CKD)
8. Hypertension
9. Osteoporosis
10. Stroke
Impact of Chronic Diseases
The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the WHO. In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.
Chronic diseases can also have a significant impact on an individual's quality of life, limiting their ability to participate in activities they enjoy and affecting their relationships with family and friends. Moreover, the financial burden of chronic diseases can lead to poverty and reduce economic productivity, thus having a broader societal impact.
Addressing Chronic Diseases
Given the significant burden of chronic diseases, it is essential that we address them effectively. This requires a multi-faceted approach that includes:
1. Lifestyle modifications: Encouraging healthy behaviors such as regular physical activity, a balanced diet, and smoking cessation can help prevent and manage chronic diseases.
2. Early detection and diagnosis: Identifying risk factors and detecting diseases early can help prevent or delay their progression.
3. Medication management: Effective medication management is crucial for controlling symptoms and slowing disease progression.
4. Multi-disciplinary care: Collaboration between healthcare providers, patients, and families is essential for managing chronic diseases.
5. Health promotion and disease prevention: Educating individuals about the risks of chronic diseases and promoting healthy behaviors can help prevent their onset.
6. Addressing social determinants of health: Social determinants such as poverty, education, and employment can have a significant impact on health outcomes. Addressing these factors is essential for reducing health disparities and improving overall health.
7. Investing in healthcare infrastructure: Investing in healthcare infrastructure, technology, and research is necessary to improve disease detection, diagnosis, and treatment.
8. Encouraging policy change: Policy changes can help create supportive environments for healthy behaviors and reduce the burden of chronic diseases.
9. Increasing public awareness: Raising public awareness about the risks and consequences of chronic diseases can help individuals make informed decisions about their health.
10. Providing support for caregivers: Chronic diseases can have a significant impact on family members and caregivers, so providing them with support is essential for improving overall health outcomes.
Conclusion
Chronic diseases are a major public health burden that affect millions of people worldwide. Addressing these diseases requires a multi-faceted approach that includes lifestyle changes, addressing social determinants of health, investing in healthcare infrastructure, encouraging policy change, increasing public awareness, and providing support for caregivers. By taking a comprehensive approach to chronic disease prevention and management, we can improve the health and well-being of individuals and communities worldwide.
Some common examples of digestive system diseases include:
1. Irritable Bowel Syndrome (IBS): This is a chronic condition characterized by abdominal pain, bloating, and changes in bowel habits such as constipation or diarrhea.
2. Inflammatory Bowel Disease (IBD): This includes conditions such as Crohn's disease and ulcerative colitis, which cause chronic inflammation in the digestive tract.
3. Gastroesophageal Reflux Disease (GERD): This is a condition where stomach acid flows back up into the esophagus, causing heartburn and other symptoms.
4. Peptic Ulcer: This is a sore on the lining of the stomach or duodenum (the first part of the small intestine) that can cause pain, nausea, and vomiting.
5. Diverticulosis: This is a condition where small pouches form in the wall of the colon, which can become inflamed and cause symptoms such as abdominal pain and changes in bowel habits.
6. Constipation: This is a common condition where the stool is hard and difficult to pass, which can be caused by a variety of factors such as poor diet, dehydration, or certain medications.
7. Diabetes: This is a chronic condition that affects how the body regulates blood sugar levels, which can also affect the digestive system and cause symptoms such as nausea, vomiting, and abdominal pain.
8. Celiac Disease: This is an autoimmune disorder where the immune system reacts to gluten, a protein found in wheat, barley, and rye, causing inflammation and damage to the small intestine.
9. Lipidosis: This is a condition where there is an abnormal accumulation of fat in the body, which can cause symptoms such as abdominal pain, nausea, and vomiting.
10. Sarcoidosis: This is a chronic inflammatory disease that can affect various organs in the body, including the digestive system, causing symptoms such as abdominal pain, diarrhea, and weight loss.
It's important to note that this list is not exhaustive and there are many other conditions that can cause abdominal pain. If you are experiencing persistent or severe abdominal pain, it's important to seek medical attention to determine the underlying cause and receive proper treatment.
1. Ischemic stroke: This is the most common type of stroke, accounting for about 87% of all strokes. It occurs when a blood vessel in the brain becomes blocked, reducing blood flow to the brain.
2. Hemorrhagic stroke: This type of stroke occurs when a blood vessel in the brain ruptures, causing bleeding in the brain. High blood pressure, aneurysms, and blood vessel malformations can all cause hemorrhagic strokes.
3. Transient ischemic attack (TIA): Also known as a "mini-stroke," a TIA is a temporary interruption of blood flow to the brain that lasts for a short period of time, usually less than 24 hours. TIAs are often a warning sign for a future stroke and should be taken seriously.
Stroke can cause a wide range of symptoms depending on the location and severity of the damage to the brain. Some common symptoms include:
* Weakness or numbness in the face, arm, or leg
* Difficulty speaking or understanding speech
* Sudden vision loss or double vision
* Dizziness, loss of balance, or sudden falls
* Severe headache
* Confusion, disorientation, or difficulty with memory
Stroke is a leading cause of long-term disability and can have a significant impact on the quality of life for survivors. However, with prompt medical treatment and rehabilitation, many people are able to recover some or all of their lost functions and lead active lives.
The medical community has made significant progress in understanding stroke and developing effective treatments. Some of the most important advances include:
* Development of clot-busting drugs and mechanical thrombectomy devices to treat ischemic strokes
* Improved imaging techniques, such as CT and MRI scans, to diagnose stroke and determine its cause
* Advances in surgical techniques for hemorrhagic stroke
* Development of new medications to prevent blood clots and reduce the risk of stroke
Despite these advances, stroke remains a significant public health problem. According to the American Heart Association, stroke is the fifth leading cause of death in the United States and the leading cause of long-term disability. In 2017, there were over 795,000 strokes in the United States alone.
There are several risk factors for stroke that can be controlled or modified. These include:
* High blood pressure
* Diabetes mellitus
* High cholesterol levels
* Smoking
* Obesity
* Lack of physical activity
* Poor diet
In addition to these modifiable risk factors, there are also several non-modifiable risk factors for stroke, such as age (stroke risk increases with age), family history of stroke, and previous stroke or transient ischemic attack (TIA).
The medical community has made significant progress in understanding the causes and risk factors for stroke, as well as developing effective treatments and prevention strategies. However, more research is needed to improve outcomes for stroke survivors and reduce the overall burden of this disease.
Acute wounds and injuries are those that occur suddenly and heal within a relatively short period of time, usually within a few days or weeks. Examples of acute wounds include cuts, scrapes, and burns. Chronic wounds and injuries, on the other hand, are those that persist over a longer period of time and may not heal properly, leading to long-term complications. Examples of chronic wounds include diabetic foot ulcers, pressure ulcers, and chronic back pain.
Wounds and injuries can be caused by a variety of factors, including accidents, sports injuries, violence, and medical conditions such as diabetes or circulatory problems. Treatment for wounds and injuries depends on the severity of the injury and may include cleaning and dressing the wound, applying antibiotics, immobilizing broken bones, and providing pain management. In some cases, surgery may be necessary to repair damaged tissues or restore function.
Preventive measures for wounds and injuries include wearing appropriate protective gear during activities such as sports or work, following safety protocols to avoid accidents, maintaining proper hygiene and nutrition to prevent infection, and seeking medical attention promptly if an injury occurs.
Overall, wounds and injuries can have a significant impact on an individual's quality of life, and it is important to seek medical attention promptly if symptoms persist or worsen over time. Proper treatment and management of wounds and injuries can help to promote healing, reduce the risk of complications, and improve long-term outcomes.
There are several types of diabetes mellitus, including:
1. Type 1 DM: This is an autoimmune condition in which the body's immune system attacks and destroys the cells in the pancreas that produce insulin, resulting in a complete deficiency of insulin production. It typically develops in childhood or adolescence, and patients with this condition require lifelong insulin therapy.
2. Type 2 DM: This is the most common form of diabetes, accounting for around 90% of all cases. It is caused by a combination of insulin resistance (where the body's cells do not respond properly to insulin) and impaired insulin secretion. It is often associated with obesity, physical inactivity, and a diet high in sugar and unhealthy fats.
3. Gestational DM: This type of diabetes develops during pregnancy, usually in the second or third trimester. Hormonal changes and insulin resistance can cause blood sugar levels to rise, putting both the mother and baby at risk.
4. LADA (Latent Autoimmune Diabetes in Adults): This is a form of type 1 DM that develops in adults, typically after the age of 30. It shares features with both type 1 and type 2 DM.
5. MODY (Maturity-Onset Diabetes of the Young): This is a rare form of diabetes caused by genetic mutations that affect insulin production. It typically develops in young adulthood and can be managed with lifestyle changes and/or medication.
The symptoms of diabetes mellitus can vary depending on the severity of the condition, but may include:
1. Increased thirst and urination
2. Fatigue
3. Blurred vision
4. Cuts or bruises that are slow to heal
5. Tingling or numbness in hands and feet
6. Recurring skin, gum, or bladder infections
7. Flu-like symptoms such as weakness, dizziness, and stomach pain
8. Dark, velvety skin patches (acanthosis nigricans)
9. Yellowish color of the skin and eyes (jaundice)
10. Delayed healing of cuts and wounds
If left untreated, diabetes mellitus can lead to a range of complications, including:
1. Heart disease and stroke
2. Kidney damage and failure
3. Nerve damage (neuropathy)
4. Eye damage (retinopathy)
5. Foot damage (neuropathic ulcers)
6. Cognitive impairment and dementia
7. Increased risk of infections and other diseases, such as pneumonia, gum disease, and urinary tract infections.
It is important to note that not all individuals with diabetes will experience these complications, and that proper management of the condition can greatly reduce the risk of developing these complications.
1. Rabies: A deadly viral disease that affects the central nervous system and is transmitted through the saliva of infected animals, usually through bites.
2. Distemper: A highly contagious viral disease that affects dogs, raccoons, and other carnivorous animals, causing symptoms such as seizures, vomiting, and diarrhea.
3. Parvo: A highly contagious viral disease that affects dogs and other animals, causing severe gastrointestinal symptoms and dehydration.
4. Heartworm: A parasitic infection caused by a worm that infects the heart and blood vessels of animals, particularly dogs and cats.
5. Feline immunodeficiency virus (FIV): A viral disease that weakens the immune system of cats, making them more susceptible to other infections and diseases.
6. Avian influenza: A type of flu that affects birds, including chickens and other domesticated fowl, as well as wild birds.
7. Tuberculosis: A bacterial infection that can affect a wide range of animals, including cattle, pigs, and dogs.
8. Leptospirosis: A bacterial infection that can affect a wide range of animals, including dogs, cats, and wildlife, and can cause symptoms such as fever, kidney failure, and death.
9. Lyme disease: A bacterial infection transmitted through the bite of an infected tick, primarily affecting dogs and humans.
10. Fungal infections: Fungal infections can affect a wide range of animals, including dogs, cats, and livestock, and can cause symptoms such as skin lesions, respiratory problems, and death.
Animal diseases can have a significant impact on animal health and welfare, as well as human health and the economy. They can also be transmitted between animals and humans, making it important to monitor and control animal disease outbreaks to prevent their spread.
Vaccination is an effective way to prevent animal diseases in pets and livestock. Regular vaccinations can help protect against common diseases such as distemper, hepatitis, parvovirus, and rabies, among others. Vaccines can be administered orally, through injection, or through a nasal spray.
Preventative care is key in avoiding animal disease outbreaks. Some of the best ways to prevent animal diseases include:
1. Regular vaccinations: Keeping pets and livestock up to date on their vaccinations can help protect against common diseases.
2. Proper sanitation and hygiene: Keeping living areas clean and free of waste can help prevent the spread of disease-causing bacteria and viruses.
3. Avoiding contact with wild animals: Wild animals can carry a wide range of diseases that can be transmitted to domesticated animals, so it's best to avoid contact with them whenever possible.
4. Proper nutrition: Providing pets and livestock with a balanced diet can help keep their immune systems strong and better able to fight off disease.
5. Monitoring for signs of illness: Regularly monitoring pets and livestock for signs of illness, such as fever, vomiting, or diarrhea, can help identify and treat diseases early on.
6. Quarantine and isolation: Isolating animals that are showing signs of illness can help prevent the spread of disease to other animals and humans.
7. Proper disposal of animal waste: Properly disposing of animal waste can help prevent the spread of disease-causing bacteria and viruses.
8. Avoiding overcrowding: Overcrowding can contribute to the spread of disease, so it's important to provide adequate living space for pets and livestock.
9. Regular veterinary care: Regular check-ups with a veterinarian can help identify and treat diseases early on, and also provide guidance on how to prevent animal diseases.
10. Emergency preparedness: Having an emergency plan in place for natural disasters or other unexpected events can help protect pets and livestock from disease outbreaks.
There are different types of Breast Neoplasms such as:
1. Fibroadenomas: These are benign tumors that are made up of glandular and fibrous tissues. They are usually small and round, with a smooth surface, and can be moved easily under the skin.
2. Cysts: These are fluid-filled sacs that can develop in both breast tissue and milk ducts. They are usually benign and can disappear on their own or be drained surgically.
3. Ductal Carcinoma In Situ (DCIS): This is a precancerous condition where abnormal cells grow inside the milk ducts. If left untreated, it can progress to invasive breast cancer.
4. Invasive Ductal Carcinoma (IDC): This is the most common type of breast cancer and starts in the milk ducts but grows out of them and invades surrounding tissue.
5. Invasive Lobular Carcinoma (ILC): It originates in the milk-producing glands (lobules) and grows out of them, invading nearby tissue.
Breast Neoplasms can cause various symptoms such as a lump or thickening in the breast or underarm area, skin changes like redness or dimpling, change in size or shape of one or both breasts, discharge from the nipple, and changes in the texture or color of the skin.
Treatment options for Breast Neoplasms may include surgery such as lumpectomy, mastectomy, or breast-conserving surgery, radiation therapy which uses high-energy beams to kill cancer cells, chemotherapy using drugs to kill cancer cells, targeted therapy which uses drugs or other substances to identify and attack cancer cells while minimizing harm to normal cells, hormone therapy, immunotherapy, and clinical trials.
It is important to note that not all Breast Neoplasms are cancerous; some are benign (non-cancerous) tumors that do not spread or grow.
1. Infection: Bacterial or viral infections can develop after surgery, potentially leading to sepsis or organ failure.
2. Adhesions: Scar tissue can form during the healing process, which can cause bowel obstruction, chronic pain, or other complications.
3. Wound complications: Incisional hernias, wound dehiscence (separation of the wound edges), and wound infections can occur.
4. Respiratory problems: Pneumonia, respiratory failure, and atelectasis (collapsed lung) can develop after surgery, particularly in older adults or those with pre-existing respiratory conditions.
5. Cardiovascular complications: Myocardial infarction (heart attack), cardiac arrhythmias, and cardiac failure can occur after surgery, especially in high-risk patients.
6. Renal (kidney) problems: Acute kidney injury or chronic kidney disease can develop postoperatively, particularly in patients with pre-existing renal impairment.
7. Neurological complications: Stroke, seizures, and neuropraxia (nerve damage) can occur after surgery, especially in patients with pre-existing neurological conditions.
8. Pulmonary embolism: Blood clots can form in the legs or lungs after surgery, potentially causing pulmonary embolism.
9. Anesthesia-related complications: Respiratory and cardiac complications can occur during anesthesia, including respiratory and cardiac arrest.
10. delayed healing: Wound healing may be delayed or impaired after surgery, particularly in patients with pre-existing medical conditions.
It is important for patients to be aware of these potential complications and to discuss any concerns with their surgeon and healthcare team before undergoing surgery.
HIV (human immunodeficiency virus) infection is a condition in which the body is infected with HIV, a type of retrovirus that attacks the body's immune system. HIV infection can lead to AIDS (acquired immunodeficiency syndrome), a condition in which the immune system is severely damaged and the body is unable to fight off infections and diseases.
There are several ways that HIV can be transmitted, including:
1. Sexual contact with an infected person
2. Sharing of needles or other drug paraphernalia with an infected person
3. Mother-to-child transmission during pregnancy, childbirth, or breastfeeding
4. Blood transfusions ( although this is rare in developed countries due to screening processes)
5. Organ transplantation (again, rare)
The symptoms of HIV infection can be mild at first and may not appear until several years after infection. These symptoms can include:
1. Fever
2. Fatigue
3. Swollen glands in the neck, armpits, and groin
4. Rash
5. Muscle aches and joint pain
6. Night sweats
7. Diarrhea
8. Weight loss
If left untreated, HIV infection can progress to AIDS, which is a life-threatening condition that can cause a wide range of symptoms, including:
1. Opportunistic infections (such as pneumocystis pneumonia)
2. Cancer (such as Kaposi's sarcoma)
3. Wasting syndrome
4. Neurological problems (such as dementia and seizures)
HIV infection is diagnosed through a combination of blood tests and physical examination. Treatment typically involves antiretroviral therapy (ART), which is a combination of medications that work together to suppress the virus and slow the progression of the disease.
Prevention methods for HIV infection include:
1. Safe sex practices, such as using condoms and dental dams
2. Avoiding sharing needles or other drug-injecting equipment
3. Avoiding mother-to-child transmission during pregnancy, childbirth, or breastfeeding
4. Post-exposure prophylaxis (PEP), which is a short-term treatment that can prevent infection after potential exposure to the virus
5. Pre-exposure prophylaxis (PrEP), which is a daily medication that can prevent infection in people who are at high risk of being exposed to the virus.
It's important to note that HIV infection is manageable with proper treatment and care, and that people living with HIV can lead long and healthy lives. However, it's important to be aware of the risks and take steps to prevent transmission.
1. Coronary artery disease: The narrowing or blockage of the coronary arteries, which supply blood to the heart.
2. Heart failure: A condition in which the heart is unable to pump enough blood to meet the body's needs.
3. Arrhythmias: Abnormal heart rhythms that can be too fast, too slow, or irregular.
4. Heart valve disease: Problems with the heart valves that control blood flow through the heart.
5. Heart muscle disease (cardiomyopathy): Disease of the heart muscle that can lead to heart failure.
6. Congenital heart disease: Defects in the heart's structure and function that are present at birth.
7. Peripheral artery disease: The narrowing or blockage of blood vessels that supply oxygen and nutrients to the arms, legs, and other organs.
8. Deep vein thrombosis (DVT): A blood clot that forms in a deep vein, usually in the leg.
9. Pulmonary embolism: A blockage in one of the arteries in the lungs, which can be caused by a blood clot or other debris.
10. Stroke: A condition in which there is a lack of oxygen to the brain due to a blockage or rupture of blood vessels.
The causes of colorectal neoplasms are not fully understood, but factors such as age, genetics, diet, and lifestyle have been implicated. Symptoms of colorectal cancer can include changes in bowel habits, blood in the stool, abdominal pain, and weight loss. Screening for colorectal cancer is recommended for adults over the age of 50, as it can help detect early-stage tumors and improve survival rates.
There are several subtypes of colorectal neoplasms, including adenomas (which are precancerous polyps), carcinomas (which are malignant tumors), and lymphomas (which are cancers of the immune system). Treatment options for colorectal cancer depend on the stage and location of the tumor, but may include surgery, chemotherapy, radiation therapy, or a combination of these.
Research into the causes and treatment of colorectal neoplasms is ongoing, and there has been significant progress in recent years. Advances in screening and treatment have improved survival rates for patients with colorectal cancer, and there is hope that continued research will lead to even more effective treatments in the future.
Recurrence can also refer to the re-emergence of symptoms in a previously treated condition, such as a chronic pain condition that returns after a period of remission.
In medical research, recurrence is often studied to understand the underlying causes of disease progression and to develop new treatments and interventions to prevent or delay its return.
Some common types of mental disorders include:
1. Anxiety disorders: These conditions cause excessive worry, fear, or anxiety that interferes with daily life. Examples include generalized anxiety disorder, panic disorder, and social anxiety disorder.
2. Mood disorders: These conditions affect a person's mood, causing feelings of sadness, hopelessness, or anger that persist for weeks or months. Examples include depression, bipolar disorder, and seasonal affective disorder.
3. Personality disorders: These conditions involve patterns of thought and behavior that deviate from the norm of the average person. Examples include borderline personality disorder, narcissistic personality disorder, and antisocial personality disorder.
4. Psychotic disorders: These conditions cause a person to lose touch with reality, resulting in delusions, hallucinations, or disorganized thinking. Examples include schizophrenia, schizoaffective disorder, and brief psychotic disorder.
5. Trauma and stressor-related disorders: These conditions develop after a person experiences a traumatic event, such as post-traumatic stress disorder (PTSD).
6. Dissociative disorders: These conditions involve a disconnection or separation from one's body, thoughts, or emotions. Examples include dissociative identity disorder (formerly known as multiple personality disorder) and depersonalization disorder.
7. Neurodevelopmental disorders: These conditions affect the development of the brain and nervous system, leading to symptoms such as difficulty with social interaction, communication, and repetitive behaviors. Examples include autism spectrum disorder, attention deficit hyperactivity disorder (ADHD), and Rett syndrome.
Mental disorders can be diagnosed by a mental health professional using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which provides criteria for each condition. Treatment typically involves a combination of medication and therapy, such as cognitive-behavioral therapy or psychodynamic therapy, depending on the specific disorder and individual needs.
Asthma can cause recurring episodes of wheezing, coughing, chest tightness, and shortness of breath. These symptoms occur when the muscles surrounding the airways contract, causing the airways to narrow and swell. This can be triggered by exposure to environmental allergens or irritants such as pollen, dust mites, pet dander, or respiratory infections.
There is no cure for asthma, but it can be managed with medication and lifestyle changes. Treatment typically includes inhaled corticosteroids to reduce inflammation, bronchodilators to open up the airways, and rescue medications to relieve symptoms during an asthma attack.
Asthma is a common condition that affects people of all ages, but it is most commonly diagnosed in children. According to the American Lung Association, more than 25 million Americans have asthma, and it is the third leading cause of hospitalization for children under the age of 18.
While there is no cure for asthma, early diagnosis and proper treatment can help manage symptoms and improve quality of life for those affected by the condition.
1. Osteoarthritis: A degenerative joint disease that affects the cartilage and bone in the joints, leading to pain, stiffness, and limited mobility.
2. Rheumatoid arthritis: An autoimmune disorder that causes inflammation in the joints, leading to pain, swelling, and deformity.
3. Fibromyalgia: A chronic condition characterized by widespread muscle pain, fatigue, and sleep disturbances.
4. Tendinitis: Inflammation of a tendon, which can cause pain and stiffness in the affected area.
5. Bursitis: Inflammation of the fluid-filled sacs (bursae) that cushion joints, leading to pain, swelling, and limited mobility.
6. Carpal tunnel syndrome: Compression of the median nerve in the wrist, leading to numbness, tingling, and weakness in the hand and fingers.
7. Sprains and strains: Injuries to the ligaments or muscles, often caused by sudden twisting or overstretching.
8. Back pain: Pain in the back that can be caused by a variety of factors, such as muscle strain, herniated discs, or spinal stenosis.
9. Osteoporosis: A condition characterized by weak and brittle bones, leading to an increased risk of fractures.
10. Clubfoot: A congenital deformity in which the foot is turned inward and downward.
These are just a few examples of musculoskeletal diseases, and there are many more conditions that can affect the muscles, bones, and joints. Treatment options for these conditions can range from conservative methods such as physical therapy and medication to surgical interventions. It's important to seek medical attention if you experience any persistent or severe symptoms in your musculoskeletal system.
Type 2 diabetes can be managed through a combination of diet, exercise, and medication. In some cases, lifestyle changes may be enough to control blood sugar levels, while in other cases, medication or insulin therapy may be necessary. Regular monitoring of blood sugar levels and follow-up with a healthcare provider are important for managing the condition and preventing complications.
Common symptoms of type 2 diabetes include:
* Increased thirst and urination
* Fatigue
* Blurred vision
* Cuts or bruises that are slow to heal
* Tingling or numbness in the hands and feet
* Recurring skin, gum, or bladder infections
If left untreated, type 2 diabetes can lead to a range of complications, including:
* Heart disease and stroke
* Kidney damage and failure
* Nerve damage and pain
* Eye damage and blindness
* Foot damage and amputation
The exact cause of type 2 diabetes is not known, but it is believed to be linked to a combination of genetic and lifestyle factors, such as:
* Obesity and excess body weight
* Lack of physical activity
* Poor diet and nutrition
* Age and family history
* Certain ethnicities (e.g., African American, Hispanic/Latino, Native American)
* History of gestational diabetes or delivering a baby over 9 lbs.
There is no cure for type 2 diabetes, but it can be managed and controlled through a combination of lifestyle changes and medication. With proper treatment and self-care, people with type 2 diabetes can lead long, healthy lives.
Malignant prostatic neoplasms are cancerous tumors that can be aggressive and spread to other parts of the body (metastasize). The most common type of malignant prostatic neoplasm is adenocarcinoma of the prostate, which accounts for approximately 95% of all prostate cancers. Other types of malignant prostatic neoplasms include sarcomas and small cell carcinomas.
Prostatic neoplasms can be diagnosed through a variety of tests such as digital rectal examination (DRE), prostate-specific antigen (PSA) test, imaging studies (ultrasound, CT scan or MRI), and biopsy. Treatment options for prostatic neoplasms depend on the type, stage, and grade of the tumor, as well as the patient's age and overall health. Treatment options can include active surveillance, surgery (robotic-assisted laparoscopic prostatectomy or open prostatectomy), radiation therapy (external beam radiation therapy or brachytherapy), and hormone therapy.
In summary, Prostatic Neoplasms are tumors that occur in the prostate gland, which can be benign or malignant. The most common types of malignant prostatic neoplasms are adenocarcinoma of the prostate, and other types include sarcomas and small cell carcinomas. Diagnosis is done through a variety of tests, and treatment options depend on the type, stage, and grade of the tumor, as well as the patient's age and overall health.
Premature birth can be classified into several categories based on gestational age at birth:
1. Extreme prematurity: Born before 24 weeks of gestation.
2. Very preterm: Born between 24-27 weeks of gestation.
3. Moderate to severe preterm: Born between 28-32 weeks of gestation.
4. Late preterm: Born between 34-36 weeks of gestation.
The causes of premature birth are not fully understood, but several factors have been identified as increasing the risk of premature birth. These include:
1. Previous premature birth
2. Multiple gestations (twins, triplets etc.)
3. History of cervical surgery or cervical incompetence
4. Chronic medical conditions such as hypertension and diabetes
5. Infections such as group B strep or urinary tract infections
6. Pregnancy-related complications such as preeclampsia and placenta previa
7. Stress and poor social support
8. Smoking, alcohol and drug use during pregnancy
9. Poor nutrition and lack of prenatal care.
Premature birth can have significant short-term and long-term health consequences for the baby, including respiratory distress syndrome, bronchopulmonary dysplasia, intraventricular hemorrhage, retinopathy of prematurity and necrotizing enterocolitis. Children who are born prematurely may also have developmental delays, learning disabilities and behavioral problems later in life.
There is no single test that can predict premature birth with certainty, but several screening tests are available to identify women at risk. These include ultrasound examination, maternal serum screening for estriol and pregnancy-associated plasma protein A (PAPP-A), and cervical length measurement.
While there is no proven way to prevent premature birth entirely, several strategies have been shown to reduce the risk, including:
1. Progesterone supplementation: Progesterone appears to help prevent preterm labor in some women with a history of previous preterm birth or other risk factors.
2. Corticosteroids: Corticosteroids given to mothers at risk of preterm birth can help mature the baby's lungs and reduce the risk of respiratory distress syndrome.
3. Calcium supplementation: Calcium may help improve fetal bone development and reduce the risk of premature birth.
4. Good prenatal care: Regular prenatal check-ups, proper nutrition and avoiding smoking, alcohol and drug use during pregnancy can help reduce the risk of premature birth.
5. Avoiding stress: Stress can increase the risk of premature birth, so finding ways to manage stress during pregnancy is important.
6. Preventing infections: Infections such as group B strep and urinary tract infections can increase the risk of premature birth, so it's important to take steps to prevent them.
7. Maintaining a healthy weight gain during pregnancy: Excessive weight gain during pregnancy can increase the risk of premature birth.
8. Avoiding preterm contractions: Preterm contractions can be a sign of impending preterm labor, so it's important to be aware of them and seek medical attention if they occur.
9. Prolonged gestation: Prolonging pregnancy beyond 37 weeks may reduce the risk of premature birth.
10. Cervical cerclage: A cervical cerclage is a stitch used to close the cervix and prevent preterm birth in women with a short cervix or other risk factors.
It's important to note that not all of these strategies will be appropriate or effective for every woman, so it's important to discuss your individual risk factors and any concerns you may have with your healthcare provider.
Examples of communicable diseases include:
1. Influenza (the flu)
2. Measles
3. Tuberculosis (TB)
4. HIV/AIDS
5. Malaria
6. Hepatitis B and C
7. Chickenpox
8. Whooping cough (pertussis)
9. Meningitis
10. Pneumonia
Communicable diseases can be spread through various means, including:
1. Direct contact with an infected person: This includes touching, hugging, shaking hands, or sharing food and drinks with someone who is infected.
2. Indirect contact with contaminated surfaces or objects: Pathogens can survive on surfaces for a period of time and can be transmitted to people who come into contact with those surfaces.
3. Airborne transmission: Some diseases, such as the flu and TB, can be spread through the air when an infected person talks, coughs, or sneezes.
4. Infected insect or animal bites: Diseases such as malaria and Lyme disease can be spread through the bites of infected mosquitoes or ticks.
Prevention and control of communicable diseases are essential to protect public health. This includes:
1. Vaccination: Vaccines can prevent many communicable diseases, such as measles, mumps, and rubella (MMR), and influenza.
2. Personal hygiene: Frequent handwashing, covering the mouth when coughing or sneezing, and avoiding close contact with people who are sick can help prevent the spread of diseases.
3. Improved sanitation and clean water: Proper disposal of human waste and adequate water treatment can reduce the risk of disease transmission.
4. Screening and testing: Identifying and isolating infected individuals can help prevent the spread of disease.
5. Antibiotics and antiviral medications: These drugs can treat and prevent some communicable diseases, such as bacterial infections and viral infections like HIV.
6. Public education: Educating the public about the risks and prevention of communicable diseases can help reduce the spread of disease.
7. Contact tracing: Identifying and monitoring individuals who have been in close contact with someone who has a communicable disease can help prevent further transmission.
8. Quarantine and isolation: Quarantine and isolation measures can be used to control outbreaks by separating infected individuals from those who are not infected.
9. Improved healthcare infrastructure: Adequate healthcare facilities, such as hospitals and clinics, can help diagnose and treat communicable diseases early on, reducing the risk of transmission.
10. International collaboration: Collaboration between countries and global organizations is crucial for preventing and controlling the spread of communicable diseases that are a threat to public health worldwide, such as pandemic flu and SARS.
1. Preeclampsia: A condition characterized by high blood pressure during pregnancy, which can lead to complications such as stroke or premature birth.
2. Gestational diabetes: A type of diabetes that develops during pregnancy, which can cause complications for both the mother and the baby if left untreated.
3. Placenta previa: A condition in which the placenta is located low in the uterus, covering the cervix, which can cause bleeding and other complications.
4. Premature labor: Labor that occurs before 37 weeks of gestation, which can increase the risk of health problems for the baby.
5. Fetal distress: A condition in which the fetus is not getting enough oxygen, which can lead to serious health problems or even death.
6. Postpartum hemorrhage: Excessive bleeding after delivery, which can be life-threatening if left untreated.
7. Cesarean section (C-section) complications: Complications that may arise during a C-section, such as infection or bleeding.
8. Maternal infections: Infections that the mother may contract during pregnancy or childbirth, such as group B strep or urinary tract infections.
9. Preterm birth: Birth that occurs before 37 weeks of gestation, which can increase the risk of health problems for the baby.
10. Chromosomal abnormalities: Genetic disorders that may affect the baby's growth and development, such as Down syndrome or Turner syndrome.
It is important for pregnant women to receive regular prenatal care to monitor for any potential complications and ensure a healthy pregnancy outcome. In some cases, pregnancy complications may require medical interventions, such as hospitalization or surgery, to ensure the safety of both the mother and the baby.
1. Chronic bronchitis: This condition causes inflammation of the bronchial tubes (the airways that lead to the lungs), which can cause coughing and excessive mucus production.
2. Emphysema: This condition damages the air sacs in the lungs, making it difficult for the body to take in oxygen and release carbon dioxide.
The main causes of COPD are smoking and long-term exposure to air pollution, although genetics can also play a role. Symptoms of COPD can include shortness of breath, wheezing, and coughing, particularly during exercise or exertion. The disease can be diagnosed through pulmonary function tests, chest X-rays, and blood tests.
There is no cure for COPD, but there are several treatment options available to manage the symptoms and slow the progression of the disease. These include medications such as bronchodilators and corticosteroids, pulmonary rehabilitation programs, and lifestyle changes such as quitting smoking and increasing physical activity. In severe cases, oxygen therapy may be necessary to help the patient breathe.
Prevention is key in avoiding the development of COPD, and this includes not smoking and avoiding exposure to air pollution. Early detection and treatment can also help manage the symptoms and slow the progression of the disease. With proper management, many people with COPD are able to lead active and productive lives.
Examples of acute diseases include:
1. Common cold and flu
2. Pneumonia and bronchitis
3. Appendicitis and other abdominal emergencies
4. Heart attacks and strokes
5. Asthma attacks and allergic reactions
6. Skin infections and cellulitis
7. Urinary tract infections
8. Sinusitis and meningitis
9. Gastroenteritis and food poisoning
10. Sprains, strains, and fractures.
Acute diseases can be treated effectively with antibiotics, medications, or other therapies. However, if left untreated, they can lead to chronic conditions or complications that may require long-term care. Therefore, it is important to seek medical attention promptly if symptoms persist or worsen over time.
There are several different types of obesity, including:
1. Central obesity: This type of obesity is characterized by excess fat around the waistline, which can increase the risk of health problems such as type 2 diabetes and cardiovascular disease.
2. Peripheral obesity: This type of obesity is characterized by excess fat in the hips, thighs, and arms.
3. Visceral obesity: This type of obesity is characterized by excess fat around the internal organs in the abdominal cavity.
4. Mixed obesity: This type of obesity is characterized by both central and peripheral obesity.
Obesity can be caused by a variety of factors, including genetics, lack of physical activity, poor diet, sleep deprivation, and certain medications. Treatment for obesity typically involves a combination of lifestyle changes, such as increased physical activity and a healthy diet, and in some cases, medication or surgery may be necessary to achieve weight loss.
Preventing obesity is important for overall health and well-being, and can be achieved through a variety of strategies, including:
1. Eating a healthy, balanced diet that is low in added sugars, saturated fats, and refined carbohydrates.
2. Engaging in regular physical activity, such as walking, jogging, or swimming.
3. Getting enough sleep each night.
4. Managing stress levels through relaxation techniques, such as meditation or deep breathing.
5. Avoiding excessive alcohol consumption and quitting smoking.
6. Monitoring weight and body mass index (BMI) on a regular basis to identify any changes or potential health risks.
7. Seeking professional help from a healthcare provider or registered dietitian for personalized guidance on weight management and healthy lifestyle choices.
The causes of LBP can be broadly classified into two categories:
1. Mechanical causes: These include strains, sprains, and injuries to the soft tissues (such as muscles, ligaments, and tendons) or bones in the lower back.
2. Non-mechanical causes: These include medical conditions such as herniated discs, degenerative disc disease, and spinal stenosis.
The symptoms of LBP can vary depending on the underlying cause and severity of the condition. Common symptoms include:
* Pain that may be localized to one side or both sides of the lower back
* Muscle spasms or stiffness
* Limited range of motion in the lower back
* Difficulty bending, lifting, or twisting
* Sciatica (pain that radiates down the legs)
* Weakness or numbness in the legs
The diagnosis of LBP is based on a combination of medical history, physical examination, and diagnostic tests such as X-rays, CT scans, or MRI.
Treatment for LBP depends on the underlying cause and severity of the condition, but may include:
* Medications such as pain relievers, muscle relaxants, or anti-inflammatory drugs
* Physical therapy to improve strength and flexibility in the lower back
* Chiropractic care to realign the spine and relieve pressure on the joints and muscles
* Injections of corticosteroids or hyaluronic acid to reduce inflammation and relieve pain
* Surgery may be considered for severe or chronic cases that do not respond to other treatments.
Prevention strategies for LBP include:
* Maintaining a healthy weight to reduce strain on the lower back
* Engaging in regular exercise to improve muscle strength and flexibility
* Using proper lifting techniques to avoid straining the lower back
* Taking regular breaks to stretch and move around if you have a job that involves sitting or standing for long periods
* Managing stress through relaxation techniques such as meditation or deep breathing.
1991 Vallejo helicopter crash
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Wal-Mart: The High Cost of Low Price
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Dynamic knowledge repository
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Browsing by Subject "Databases, Factual"
Subjects: Databases, Factual - Digital Collections - National Library of Medicine Search Results
Subjects: Databases, Factual - Digital Collections - National Library of Medicine Search Results
HTA 101: VII. RETRIEVE EVIDENCE
Results of search for 'su:{Databases, Factual.}'
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WHO HQ Library catalog
Outcomes of trauma care at centers treating a higher proportion of older patients: the case for geriatric trauma centers
Browsing 2. Regional Office for Africa by Subject
Monitoring vaccine safety using the Vaccine Safety Datalink: utilizing immunization registries for pandemic influenza
DR IB 2019/1 | Legal database
Briefings in bioinformatics - NLM Catalog - NCBI
NIH VideoCast - MIDAS Symposium
The National Library of Medicine's Toxicology and Environmental Health Information Program - Toxicology and Environmental...
Browsing Journal Articles - Bulletin by Subject
Sameer Hirji, M.D. | Harvard Catalyst Profiles | Harvard Catalyst
COVID-19 Databases and Journals
Recent trends in the treatment of spontaneous intracerebral hemorrhage: analysis of a nationwide inpatient database - PubMed
NCBI genetic resources supporting immunogenetic research - PubMed
Adverse events associated with prolonged antibiotic use - PubMed
Effects of Prebiotic and Probiotic Supplementation on Lactase Deficiency and Lactose Intolerance: A Systematic Review of...
Care models in the management of haemophilia: a systematic review - PubMed
CellMinerCDB: NCATS Is a Web-Based Portal Integrating Public Cancer Cell Line Databases for Pharmacogenomic Explorations -...
Impact of COVID-19 Pandemic on the National PPM Tuberculosis Control Project in Korea: the Korean PPM Monitoring Database...
Publication Detail
Public investments in the development of GeneXpert molecular diagnostic technology - PubMed
Advanced Search Results - Public Health Image Library(PHIL)
Specialty Search Engines
ChiM - Chatbot in the Museum
Batman, The (2022) - Internet Movie Firearms Database - Guns in Movies, TV and Video Games
Patient versus healthcare professional spontaneous adverse drug reaction reporting: a systematic review<...
Centers1
- As always, we thank you for using our products and services, for suggesting improvements and for promoting the use of our databases and interfaces in your hospitals, medical centers, and companies. (nih.gov)
Data11
- In CHIM, structured knowledge from museum databases on the one hand and language models trained on large data sets on the other hand are used for this purpose. (dfki.de)
- Many factual questions can be answered directly using data from the museum database. (dfki.de)
- The database contains data from both governmental and private research funding bodies - 11 in total. (vr.se)
- Many of you may have heard that NLM is planning to expand PubMed with data from other NLM databases. (nih.gov)
- I am comfortable with both using factual data based on research and presenting my own personal opinions in my writing. (freelancer.com)
- This measurement gives factual data. (brighthub.com)
- The Open Data Commons Attribution License is a license agreement intended to allow users to freely share, modify, and use this Database subject only to the attribution requirements set out in Section 4. (physionet.org)
- Sometimes the contents of a database, or the database itself, can be covered by other rights not addressed here (such as private contracts, trademark over the name, or privacy rights / data protection rights over information in the contents), and so you are advised that you may have to consult other documents or clear other rights before doing activities not covered by this License. (physionet.org)
- For example, the contents of the Database could be factual data or works such as images, audiovisual material, text, or sounds. (physionet.org)
- The Index Section creates and maintains the MEDLINE® database, coordinates data entry, indexing, and commentary contracts. (nih.gov)
- These reports are based on the data obtained from the PRAT database. (nih.gov)
MEDLINE4
- The most widely used of these resources for HTA are the large bibliographic databases, particularly MEDLINE, produced by NLM, and Embase, produced by Elsevier. (nih.gov)
- On June 26, 1997, NLM announced that its MEDLINE database of more than 9 million references to articles published in 3800 biomedical journals may be accessed free of charge on the World Wide Web via PubMed and Internet Grateful Med. (nih.gov)
- The biomedical literature is a tremendously rich information source, and the collection of abstracts in the National Library of Medicine's MEDLINE database summarizes that literature comprehensively. (nih.gov)
- In this paper, we report a system, EDGAR (Extraction of Drugs, Genes and Relations), designed to extract factual information from the MEDLINE database on the relationships between genes, drugs and cells. (nih.gov)
Bibliographic databases2
- Among the major categories, bibliographic databases have indexed citations (or "records") for journal articles and other publications. (nih.gov)
- The MEDLARS Management Section (MMS) provides access to bibliographic databases and publications through its overall development and management activities. (nih.gov)
19991
- 1999]. Our goal in this work is to extract factual assertions, in the form of first order predicate calculus statements, about the relationships between genes and drugs in cancer therapy. (nih.gov)
Extraction2
- Database Right" - Means rights resulting from the Chapter III ("sui generis") rights in the Database Directive (as amended and as transposed by member states), which includes the Extraction and Re-utilisation of the whole or a Substantial part of the Contents, as well as any similar rights available in the relevant jurisdiction under Section 10.4. (physionet.org)
- Approaches to the extraction of factual assertions from biomedical text vary widely. (nih.gov)
Collections2
- Academic libraries acquire e-books and manage a variety of e-book collections from a number of distributors, aggregators and publishers using their rich experience of negotiations from the earlier phase of working with e-journals and databases of full-text articles as well as other digital resources. (informationr.net)
- The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references. (nih.gov)
Cochrane Library1
- These reviews are made available via the Cochrane Library, which also includes certain databases and registers produced by the Cochrane Collaboration as well as some produced by other organizations. (nih.gov)
Abstracts2
- The Database of Abstracts of Reviews and Dissemination (DARE) and the NHS Economic Evaluation Database (NHS EED) are produced by the Centre for Reviews and Dissemination (CRD) at the University of York. (nih.gov)
- Chemical Abstracts Service (CAS) produces chemistry-related databases, covering more than 9,500 journals and patents from 50 national and international patent offices with unrivaled currency. (piug.org)
Organisations1
- Species 2000 is a "federation" of database organisations working closely with users, taxonomists and sponsoring agencies. (vifabio.de)
20201
- Please note that it has stopped updating as of October 9, 2020 and all new articles are now being integrated into the WHO COVID-19 database external icon . (cdc.gov)
Subject3
- The research projects in the database are classified by subject according to Statistics Sweden's classification standard from 2011. (vr.se)
- Regardless of whether you are searching in the library catalogue, a subject-specific database or a search engine: the key to finding relevant literature is the search terms that you use. (reutlingen-university.de)
- Some subject databases even offer a standardised key word index. (reutlingen-university.de)
Publication1
- The IP.com Prior Art Database is a unique database dedicated to the publication of technical disclosure documents. (piug.org)
Widely1
- The participating databases are widely distributed throughout the world and currently number 40. (vifabio.de)
Patents2
- With BizInt Smart Charts for Patents you can create reports from patent and literature databases on STN, Dialog, Questel*Orbit, MicroPatent and Delphion - and distribute HTML reports with automatically generated links to full patents. (piug.org)
- Today, the database known as CLAIMS® represents the largest, most reliable, text-searchable, computerized collection of U.S. patents in the world. (piug.org)
Researchers4
- Below are selected databases and journals to help researchers find scholarly articles about COVID-19 (2019 Novel Coronavirus). (cdc.gov)
- Our search results are now being sent to the WHO COVID-19 Database external icon to make it easier for them to be searched, downloaded, and used by researchers worldwide. (cdc.gov)
- Swecris is a national database, where you can see how the participating research funding bodies have distributed their funds to researchers in Sweden. (vr.se)
- This database will be useful for engineers, researchers, and scientists to create new techniques to modernize and maximize operational efficiency of solar power harnessing. (brighthub.com)
Findings1
- ATSDR should immediately get access to the OREIS database, confirm these findings, and release this information to the public. (cdc.gov)
Terms2
- Database" - A collection of material (the Contents) arranged in a systematic or methodical way and individually accessible by electronic or other means offered under the terms of this License. (physionet.org)
- Licensor" - Means the Person that offers the Database under the terms of this License. (physionet.org)
Claims1
- This study's objective was to estimate risks of severe ADEs associated with long-term ciprofloxacin, doxycycline, and amoxicillin exposure using three large databases: one electronic medical record (General Practice Research Database) and two claims databases (UnitedHealthcare, HMO Research Network). (nih.gov)
Maintains1
- The PRAT program administrator maintains a database of fellows for application management, tracking, and reporting purposes. (nih.gov)
Substantial3
- The existing global species databases presently account for some 40% of the total known species, so substantial investment in new databases will be needed for full coverage of all taxa to be achieved. (vifabio.de)
- Derivative Database" - Means a database based upon the Database, and includes any translation, adaptation, arrangement, modification, or any other alteration of the Database or of a Substantial part of the Contents. (physionet.org)
- This includes, but is not limited to, Extracting or Re-utilising the whole or a Substantial part of the Contents in a new Database. (opendatacommons.org)
Library5
- The National Information Center on Health Services Research & Health Care Technology (NICHSR) of the US National Library of Medicine (NLM) provides an extensive, organized set of the many, evolving databases, publications, outreach and training, and other information resources for HTA. (nih.gov)
- This database is compiled by the National Library of Medicine from COVID-19 articles in PubMed. (cdc.gov)
- As academic libraries were the main buyers of scholarly monographs that rarely appeared as entirely commercial products, the stress on library budgets from the acquisition of other electronic resources (e-journals, databases, e-textbooks) disrupts the existing business model of monograph production severely ( Svensson and Eriksson, 2013 ), so new ways for their distribution are sought (see www.knowledgeunlatched.org or www.oapen.org ). (informationr.net)
- Hello, I'm Sheldon Kotzin and along with the other persons on the panel, I represent the National Library of Medicine staff who index, develop databases and their interfaces, and provide access and user support to these databases. (nih.gov)
- The video "Searching Databases" from Yavapai College Library shows how you can use an advanced search to find more specific results. (reutlingen-university.de)
Content3
- Databases can contain a wide variety of types of content (images, audiovisual material, and sounds all in the same database, for example), and so this license only governs the rights over the Database, and not the contents of the Database individually. (physionet.org)
- While program directors perform periodic analyses of database content to assess PRAT fellows' career outcomes, no external evaluation of the program has ever been conducted. (nih.gov)
- This statement cannot be supported by publicly available information from both DOE itself (documented in the OREIS database, the technical information that supports the DOE ORR's own ASER (Annual Site Environmental Report), and scientific reports of fish tissue content available from the TVA (Tennessee Valley Authority). (cdc.gov)
Errors2
Term1
- ADE hospitalizations during long-term exposure were not observed in Database A. ADEs during long-term amoxicillin were seen only in Database C with 5 ADEs or 1.2(0.4-2.7) ADEs/100,000 pds exposure. (nih.gov)
Types1
- Across the hundreds of publicly available electronic databases of potential relevance to HTA are various general types. (nih.gov)
Version5
- Wistat : women's indicators and statistics database (version 3) : users' guide and reference manual. (who.int)
- WHOTERM : terminology database management system, version 1.0, for PCs running MS-DOS, user's manual. (who.int)
- The last version of the CDC COVID-19 database will be archived and remain available on this website. (cdc.gov)
- At our exhibition stand learn about improved STN patent databases, including IPC version 8 (IPC 2006) changes, new features of the reloaded Derwent World Patent Index file, and new EPO Register Legal Status in our EP full-text file. (piug.org)
- A plain language summary of the Open Database License is available as well as a plain text version . (opendatacommons.org)
Articles1
- The CDC Database of COVID-19 Research Articles is now a part of the WHO COVID-19 database external icon . (cdc.gov)
Products1
- It does this primarily through MEDLARS® (Medical Literature Analysis and Retrieval System), the Library's computer-based system for storing and retrieving bibliographic and factual information, and the printed products derived from this system, such as International Nursing Index, Index to Dental Literature, and others. (nih.gov)
System3
- WHOTERM : terminology database management system, thesaurus. (who.int)
- Each database covers all known species in the group, using a consistent taxonomic system. (vifabio.de)
- High levels of these specific radionuclides have been earmarked in the OREIS (Oak Ridge Environmental Information System) database for decades. (cdc.gov)
Services1
- Referral databases provide information about organizations, services and other information sources. (nih.gov)
Clinical trials1
- In addition, there are certain specialized or more focused databases in such areas as ongoing clinical trials and their results (e.g. (nih.gov)
Scientists1
- The database is specifically designed for scientists. (piug.org)
Form1
- Collective Database" - Means this Database in unmodified form as part of a collection of independent databases in themselves that together are assembled into a collective whole. (physionet.org)
Text2
Accessible2
Work3
- Tip: It is always worth looking in the help function of the respective databases to find out which tricks work best for that database, for example which wildcards can be used. (reutlingen-university.de)
- Conveying does not include interaction with a user through a computer network, or creating and Using a Produced Work, where no transfer of a copy of the Database or a Derivative Database occurs. (physionet.org)
- A work that constitutes a Collective Database will not be considered a Derivative Database. (opendatacommons.org)
Electronic1
- Members of Reutlingen University can log into our VPN to access our e-books, electronic journals and licensed databases when off-campus. (reutlingen-university.de)
Groups1
- This is being achieved by bringing together an array of global species databases covering each of the major groups of organisms. (vifabio.de)
Charts1
- Our BizInt Smart Charts software helps you create, customize, and distribute tabular reports from patent and drug pipeline databases. (piug.org)
Users2
- The Open Database License (ODbL) is a license agreement intended to allow users to freely share, modify, and use this Database while maintaining this same freedom for others. (opendatacommons.org)
- Finally, the ODbL is also an agreement in contract for users of this Database to act in certain ways in return for accessing this Database. (opendatacommons.org)
Legal1
- Parliament and of the Council of 11 March 1996 on the legal protection of databases, as amended or succeeded. (physionet.org)
Covers1
- The database covers the years from 2007 and onwards. (vr.se)
Contents1
- Contents" - The contents of this Database, which includes the information, independent works, or other material collected into the Database. (physionet.org)